title: Ascorbate synthesis in fishes: A review.
abstract: Biosynthesis of ascorbate is known to occur in liver and/or kidney of some vertebrates; however, a recent study discovered the expression of l-gulono-γ-lactone oxidase, an enzyme essential for ascorbate synthesis, in the brain of the African lungfish, Protopterus annectens. This report provides an up-to-date review on ascorbate synthesis in fishes and the possible future directions of study in view of the discovery of the unusual site of ascorbate biosynthesis.
authors: Department of Biological Sciences, National University of Singapore, Singapore, Republic of Singapore.
authors: Biyun
authors: B
authors: Ching
authors: Shit F
authors: SF
authors: Chew
authors: Yuen K
authors: YK
authors: Ip
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000096:biosynthesis* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D050544:L-Gulonolactone Oxidase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D014714:Vertebrates / Q000378:metabolism
chemical_list: D050544:L-Gulonolactone Oxidase; D001205:Ascorbic Acid
keywords: Ascorbic acid; dehydroascorbate; gulonolactone oxidase; oxidative stress; vitamin C