title: Synthesis, Single X-ray Crystal, Spectroscopic and Photophysical Studies of Novel Heterocyclic Chalcones with Their Biological Application.
abstract: Chalcones were synthesized by reaction of 3-acetyl-2,5-dimethylfuran with corresponding active aldehyde in ethanolic NaOH. The structure of these compounds was established by elemental analysis, IR, (1)H-NMR, (13)C-NMR and EI-MS spectral analysis. UV-vis and fluorescence spectroscopy measurements provided that compounds are good absorbent and fluorescent. Fluorescence polarity study demonstrated that the compounds were sensitive to the polarity of the microenvironment provided by deferent solvents. In addition, spectroscopic and physicochemical parameters, including electronic absorption, extenction coefficient, Stokes shift, oscillator strength and transition dipole moment were investigated in order to explore the analytical potential of synthesized compounds. The anti-bacterial activity of the compounds were first tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined with the reference of standard drug Tetracycline. The results showed that compound 3 is better inhibitors of both types of the bacteria (Gram-positive and Gram-negative) as compared to tetracycline. Graphical Abstract ᅟ.
authors: Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah, 21589, Saudi Arabia, sahmad_phd@yahoo.co.in.
authors: Salman A
authors: SA
authors: Khan
authors: Abdullah M
authors: AM
authors: Asiri
authors: Hadi Mussa
authors: HM
authors: Basisi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D047188:Chalcones / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology*; D012997:Solvents / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013752:Tetracycline / Q000494:pharmacology*; D014965:X-Rays
chemical_list: C000613590:3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)-1-(2,5-dimethyl-3-furanyl)prop-2-en-1-one; D000900:Anti-Bacterial Agents; D047188:Chalcones; D005663:Furans; D011720:Pyrazoles; D012997:Solvents; D013752:Tetracycline