title: Hemophagocytic lymphohistiocytosis secondary to Varicella zoster infection in a child with Henoch-Schönlein purpura.
abstract: Hemophagocytic lymphohistiocytosis (HLH) is a fatal, hyper-inflammatory syndrome that is characterized by untimely activation of macrophages, and manifests as cytopenia, organ dysfunction, and coagulopathy. Secondary HLH can be associated with infection, drugs, malignancy, and transplantation, and is mostly triggered by infection. Herein, we report the case of a patient with Henoch-Schönlein purpura (HSP) who developed severe HLH secondary to Varicella zoster infection.
authors: Pediatric Nephrology and Rheumatology, Ankara Child Health, Hematology, Oncology Education and Research Hospital, Ankara, Turkey.
authors: Gokce
authors: G
authors: Gur
authors: Nilgun
authors: N
authors: Cakar
authors: Nermin
authors: N
authors: Uncu
authors: Ganime
authors: G
authors: Ayar
authors: Ozge
authors: O
authors: Basaran
authors: Aysel
authors: A
authors: Taktak
authors: Adem Yasin
authors: AY
authors: Koksoy
authors: Banu
authors: B
authors: Acar
authors: Fatma Semsa
authors: FS
authors: Caycı
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D002675:Child, Preschool; D005260:Female; D006562:Herpes Zoster / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications*; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis / Q000628:therapy / Q000821:virology*; D010951:Plasma Exchange
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous
keywords: Henoch-Schönlein purpura; Varicella zoster virus; hemophagocytic lymphohistiocytosis