title: A new aliphatic alcohol and cytotoxic chemical constituents from Acorus gramineus rhizomes.
abstract: A new aliphatic alcohol, (2R,6R)-oct-7-ene-2,6-diol (1), and seven other known compounds (2-8) were isolated from Acorus gramineus rhizomes. The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including 2D NMR, HR-MS, and the modified Mosher's method. Compounds 3-8 displayed consistent antiproliferative activities against the cell lines tested with IC50 values ranging from 7 to 48 μm.
authors: a Natural Products Laboratory, School of Pharmacy , Sungkyunkwan University , Suwon , Korea.
authors: Ki Hyun
authors: KH
authors: Kim
authors: Hee Rae
authors: HR
authors: Kang
authors: Hee Jeong
authors: HJ
authors: Eom
authors: Chung Sub
authors: CS
authors: Kim
authors: Sang Un
authors: SU
authors: Choi
authors: Kang Ro
authors: KR
authors: Lee
mesh_terms: D029023:Acorus / Q000737:chemistry*; D000438:Alcohols / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D027343:Rhizome / Q000737:chemistry*
chemical_list: D000438:Alcohols
keywords: Acorus gramineus; Araceae; aliphatic alcohol; cytotoxicity