title: Regression of left ventricular mass after implantation of the sutureless 3f Enable aortic bioprosthesis.
abstract: Left ventricular hypertrophy in aortic stenosis is considered a compensatory response for the maintenance of systolic function but a risk factor for cardiac morbidity and death. We investigated the degree of left ventricular mass regression after implantation of the sutureless Medtronic 3f Enable Aortic Bioprosthesis. We studied 19 patients who, from May 2010 through July 2011, underwent isolated aortic valve replacement with the 3f Enable bioprosthetic valve, with clinical and echocardiographic follow-up at 6 months. The mean age was 77.1 ± 5.1 years (range, 68-86 yr); 14 patients were women (73.7%); and the mean logistic EuroSCORE was 15.4% ± 11.8%. Echocardiography was performed preoperatively, at discharge, and at 6 months' follow-up. The left ventricular mass was calculated by means of the Devereux formula and indexed to body surface area. The left ventricular mass index decreased from 146.1 ± 47.6 g/m(2) at baseline to 118.1 ± 39.8 g/m(2) at follow-up (P=0.003). The left ventricular ejection fraction did not change significantly. The mean transaortic gradient decreased from 57.3 ± 14.2 mmHg at baseline to 12.3 ± 4.6 mmHg at discharge and 12.2 ± 5.3 mmHg at follow-up (P <0.001), and these decreases were accompanied by substantial clinical improvement. No moderate or severe paravalvular leakage was present at discharge or at follow-up. In isolated aortic stenosis, aortic valve replacement with the 3f Enable bioprosthesis results in significant regression of left ventricular mass at 6 months' follow-up. However, this regression needs to be verified by long-term echocardiographic follow-up.
authors: Giovanni
authors: G
authors: Concistrè
authors: Antonio
authors: A
authors: Miceli
authors: Federica
authors: F
authors: Marchi
authors: Francesca
authors: F
authors: Chiaramonti
authors: Mattia
authors: M
authors: Glauber
authors: Marco
authors: M
authors: Solinas
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000453:epidemiology / Q000601:surgery*; D001705:Bioprosthesis; D015897:Comorbidity; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology; D008297:Male; D011474:Prosthesis Design; D017755:Prosthesis Fitting
keywords: Aortic valve stenosis/complications/echocardiography/physiopathology/surgery; bioprosthesis; cardiomegaly/etiology; heart valve prosthesis; hypertrophy, left ventricular/etiology/complications/physiopathology; prosthesis design; ventricular remodeling