title: The direct actions of flecainide on the human cardiac ryanodine receptor: keeping open the debate on the mechanism of action of local anesthetics in CPVT.
authors: From the Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom. godfrey.smith@glasgow.ac.uk.
authors: Godfrey L
authors: GL
authors: Smith
authors: From the Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
authors: Niall
authors: N
authors: MacQuaide
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D005424:Flecainide / Q000494:pharmacology*; D006801:Humans; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects*; D019837:Ryanodine Receptor Calcium Release Channel / Q000187:drug effects*; D017180:Tachycardia, Ventricular / Q000188:drug therapy*; D061567:Voltage-Gated Sodium Channel Blockers / Q000494:pharmacology*; D000098850:Polymorphic Catecholaminergic Ventricular Tachycardia
chemical_list: D000889:Anti-Arrhythmia Agents; D019837:Ryanodine Receptor Calcium Release Channel; D061567:Voltage-Gated Sodium Channel Blockers; D005424:Flecainide
keywords: Editorials; flecainide; heart; polymorphic catecholergic ventricular tachycardia; ryanodine receptor calcium release channel; sarcoplasmic reticulum