title: Four FCRL3 Gene Polymorphisms (FCRL3_3, _5, _6, _8) Confer Susceptibility to Multiple Sclerosis: Results from a Case-Control Study.
abstract: Multiple sclerosis (MS) is an autoimmune/inflammatory neurodegenerative disease which mainly affects the central nervous system in young adults. Fc-receptor-like-3 (FCRL3) gene, which involved in immune cell regulation, has drawn lots of attentions. This study aims to investigate the association between common polymorphisms of FCRL3 gene and MS risk in a Chinese Han population. Nine single nucleotide polymorphisms (SNPs) were genotyped in 120 patients and 240 healthy controls through PCR assay. t test and chi-square test was conducted to find a possible association between FCRL3 genetic mutations and risk of MS. This analysis results performed that four SNPs, rs7528684 (FCRL3_3), rs945635 (FCRL3_5), rs3761959 (FCRL3_6), and rs2282284 (FCRL3_8), were significantly associated with the risk of MS. Further haplotype analysis showed two haplotypes of FCRL3_3, 5, 6, 8, CCAG and CGAG, presented the significant associations with the susceptibility to MS. Four SNPs in FCRL3 gene could possibly associate with the susceptibility of MS in a Chinese Han population. Moreover, the haplotype analysis confirmed that the linkage disequilibrium exists in polymorphisms in FCRL3. Based on the supporting evidence, we deduced that FCRL3_3C, FCRL3_5C, FCRL3_6A, and FCRL3_8G caused increased risk of MS. Nevertheless, large cohort studies are required in the future to validate the autoimmune function.
authors: Department of Nuclear Medicine, Tangdu Hospital, the Fourth Military Medical University (FMMU), No. 569 Xinsi Road, Baqiao District, Xi'an, 710038, China.
authors: Menghui
authors: M
authors: Yuan
authors: Department of Nuclear Medicine, Tangdu Hospital, the Fourth Military Medical University (FMMU), No. 569 Xinsi Road, Baqiao District, Xi'an, 710038, China. weilx3245@126.com.
authors: Longxiao
authors: L
authors: Wei
authors: Department of Nuclear Medicine, Tangdu Hospital, the Fourth Military Medical University (FMMU), No. 569 Xinsi Road, Baqiao District, Xi'an, 710038, China.
authors: Runsuo
authors: R
authors: Zhou
authors: Department of Nuclear Medicine, Tangdu Hospital, the Fourth Military Medical University (FMMU), No. 569 Xinsi Road, Baqiao District, Xi'an, 710038, China.
authors: Qianrong
authors: Q
authors: Bai
authors: Department of Nuclear Medicine, Tangdu Hospital, the Fourth Military Medical University (FMMU), No. 569 Xinsi Road, Baqiao District, Xi'an, 710038, China.
authors: Yixin
authors: Y
authors: Wei
authors: Department of Nuclear Medicine, Tangdu Hospital, the Fourth Military Medical University (FMMU), No. 569 Xinsi Road, Baqiao District, Xi'an, 710038, China.
authors: Wei
authors: W
authors: Zhang
authors: Department of Nuclear Medicine, Tangdu Hospital, the Fourth Military Medical University (FMMU), No. 569 Xinsi Road, Baqiao District, Xi'an, 710038, China.
authors: Yong
authors: Y
authors: Huang
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008954:Models, Biological; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*
chemical_list: C457775:FCRL3 protein, human; D011971:Receptors, Immunologic
keywords: FCRL3 gene; Haplotype; Multiple sclerosis; Single-nucleotide polymorphisms