title: Glucose metabolic abnormality is associated with defective mineral homeostasis in skeletal disorder mouse model.
abstract: Bone was reported as a crucial organ for regulating glucose homeostasis. In this study, we found that Phex mutant mice (PUG), a model of human X-linked hypophosphatemic rickets (XLH), displayed metabolic abnormality in addition to abnormal phosphate homeostasis, skeletal deformity and growth retardation. Glucose tolerance was elevated with enhanced insulin sensitivity in PUG, though circulating insulin level decreased. Interestingly, bone mineral density defects and glucose metabolic abnormality were both rescued by adding phosphorus- and calcium-enriched supplements in daily diet. Serum insulin level, glucose tolerance and insulin sensitivity showed no differences between PUG and wild-type mice with rescued osteocalcin (OCN) following treatment. Our study suggested that OCN is a potential mediator between mineral homeostasis and glucose metabolism. This investigation brings a new perspective on glucose metabolism regulation through skeleton triggered mineral homeostasis and provides new clues in clinical therapeutics of potential metabolic disorders in XLH patients.
authors: MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, China.
authors: JiangHuan
authors: J
authors: Zou
authors: XiWen
authors: X
authors: Xiong
authors: BeiBei
authors: B
authors: Lai
authors: Min
authors: M
authors: Sun
authors: Xin
authors: X
authors: Tu
authors: Xiang
authors: X
authors: Gao
mesh_terms: D000818:Animals; D001847:Bone Diseases / Q000378:metabolism*; D004195:Disease Models, Animal; D053098:Familial Hypophosphatemic Rickets / Q000178:diet therapy / Q000235:genetics / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D051379:Mice; D008817:Mice, Mutant Strains; D008903:Minerals / Q000378:metabolism*; D053402:PHEX Phosphate Regulating Neutral Endopeptidase / Q000235:genetics
chemical_list: D008903:Minerals; D053402:PHEX Phosphate Regulating Neutral Endopeptidase; C506232:Phex protein, mouse; D005947:Glucose