title: Clinical manifestations of patients with CASPR2 antibodies.
abstract: Contactin-associated protein-like 2 (CASPR2) is one of the target antigens of voltage-gated potassium channels (VGKC) complex antibodies. There has been relatively little information in the literature regarding CASPR2 autoimmunity, especially in Asian population. We investigated the presence of CASPR2 antibodies in patients with presumed autoimmune neurological disorders and described the clinical features, laboratory findings, and responses to immunotherapy. Five patients were identified to be positive for CASPR2 antibodies. The results obtained here suggested that CASPR2 antibodies might be the possible cause of epilepsy even in the absence of typical features of limbic encephalitis and that immunotherapy could provide a favorable outcome.
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
authors: Jun-Sang
authors: JS
authors: Sunwoo
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
authors: Soon-Tae
authors: ST
authors: Lee
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
authors: Jung-Ick
authors: JI
authors: Byun
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
authors: Jangsup
authors: J
authors: Moon
authors: Department of Neurology, CHA University, CHA Bundang Medical Center, Seongnam, South Korea.
authors: Jung-Won
authors: JW
authors: Shin
authors: Department of Neurology, Chung-Ang University College of Medicine, Seoul, South Korea.
authors: Da-Eun
authors: DE
authors: Jeong
authors: Department of Neurology, School of Medicine, Kyungpook National University, Daegu, South Korea.
authors: Gun-Hee
authors: GH
authors: Lee
authors: Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
authors: Seong Ho
authors: SH
authors: Jeong
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
authors: Yong-Won
authors: YW
authors: Shin
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
authors: Keun-Hwa
authors: KH
authors: Jung
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
authors: Doo Young
authors: DY
authors: Lee
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
authors: Daejong
authors: D
authors: Jeon
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
authors: Ki-Young
authors: KY
authors: Jung
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea; Protein Metabolism Medical Research Center, College of Medicine, Seoul National University, Seoul, South Korea.
authors: Manho
authors: M
authors: Kim
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea.
authors: Sang Kun
authors: SK
authors: Lee
authors: Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, Korea Autoimmune Synaptic and Paraneoplastic Encephalitis Registry (KASPER), Seoul, South Korea. Electronic address: stemcell.snu@gmail.com.
authors: Kon
authors: K
authors: Chu
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D020274:Autoimmune Diseases of the Nervous System / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D015551:Autoimmunity / Q000502:physiology*; D002648:Child; D004827:Epilepsy / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D057809:HEK293 Cells; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*
chemical_list: D001323:Autoantibodies; C403049:CNTNAP2 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins
keywords: CASPR2; Epilepsy; Immunotherapy; Neuromyotonia