title: Platelet-derived growth factor type BB and collagen matrix for soft tissue reconstruction after muco-epidermoid carcinoma removal: a possible therapeutic option.
abstract: Muco-epidermoid carcinoma (MEC) is a rare malignant tumor occurring in major and minor salivary glands. The described case shows a patient undergoing tumor resection without neck dissection. A quick diagnosis performed through clinical investigation and incisional biopsy revealed the nature of the tumor. A porcine collagen matrix was applied after the surgery in order to improve soft tissue healing. The matrix was saturated with platelet-derived growth factor type BB in order to favorite healing process and then fixed on the palate with a dental support device. Follow-up visit performed at first, second, and third weeks highlighted a quick healing of oral mucosa. Here reported is a case of a 34-year-old man who developed a muco-epidermoid oral carcinoma localized in the left upper jaw palatal side. The clinical, radiographic, and histopathologic findings, plus differential diagnoses of the case and reconstructive treatment options are also presented.
authors: Department of Human Pathology, University of Messina, University of Messina School of Dentistry, Messina, Italy.
authors: Marco
authors: M
authors: Cicciù
authors: Alan Scott
authors: AS
authors: Herford
authors: Vecchio Giada
authors: VG
authors: Maria
authors: Ennio
authors: E
authors: Bramanti
mesh_terms: D000328:Adult; D000077214:Becaplermin; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D003094:Collagen / Q000378:metabolism*; D006801:Humans; D008297:Male; D020574:Proto-Oncogene Proteins c-sis / Q000378:metabolism*; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin; D003094:Collagen