title: Renal dosing in high-risk populations.
abstract: In patients with diminished kidney function, the pharmacokinetics of many medications are altered. Alterations in absorption, distribution, and metabolism are observed in addition to altered elimination through the kidney. Classes of intravenous medications in which dose modifications are frequently required for patients with diminished kidney function include antibiotics, some anticoagulants, and chemotherapy agents. Failure to follow renal dose adjustment recommendations can lead to an increased risk of toxicity. Equations frequently used to estimate kidney function for the purpose of making renal dose adjustments include the Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations.
authors: University of Utah College of Pharmacy, University of Utah Hospital, Salt Lake City, Utah. Heather A. Nyman, PharmD, BCPS, is an assistant clinical professor of pharmacotherapy at the University of Utah College of Pharmacy and a clinical pharmacist in Adult Acute Internal Medicine at the University of Utah Hospitals and Clinics in Salt Lake City, Utah.
authors: Heather A
authors: HA
authors: Nyman
mesh_terms: D015415:Biomarkers / Q000032:analysis; D054796:Drug Dosage Calculations; D006801:Humans; D007262:Infusions, Intravenous / Q000451:nursing*; D007674:Kidney Diseases / Q000150:complications*; D007677:Kidney Function Tests; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics
chemical_list: D015415:Biomarkers; D004364:Pharmaceutical Preparations