title: Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression.
abstract: OBJECTIVE
  The aim of this prospective study was to measure the thickness of the circumpapillary retinal nerve fibre layer (cpRNFL) and the ganglion cell complex (GCC) using spectral domain optical coherence tomography (SD-OCT) in a cohort of consecutive de novo patients with pituitary macroadenomas without chiasmal compression.
  
  
  METHODS
  Twenty-two consecutive patients with pituitary macroadenoma without chiasmal compression (16 men, 6 women, aged 45.2±14.6 years, 43 eyes) entered the study between September 2011 and June 2013. Among them, 31.8% harboured a growth hormone-secreting pituitary adenoma, 27.3% a prolactin-secreting pituitary adenoma, 27.3% a corticotrophin-secreting pituitary adenoma, and 13.6% a non-secreting pituitary tumour. Eighteen subjects (nine females, nine males, mean age 36.47±6.37 years; 33 eyes) without pituitary adenoma, with normal ophthalmic examination, served as controls. In both patients and controls, cpRNFL and GCC thicknesses were measured by SD-OCT.
  
  
  RESULTS
  Patients were significantly older (P=0.02) than controls. Best corrected visual acuity, intraocular pressure, colour fundus photography, and automatic perimetry test were within the normal range in patients and controls. Conversely, cpRNFL (P=0.009) and GCC (P<0.0001) were significantly thinner in patients than in controls. The average GCC (r=0.306, P=0.046) significantly correlated with the presence of arterial hypertension. OCT parameters did not differ significantly between patients with a tumour volume above the median and those with a tumour volume below the median.
  
  
  CONCLUSIONS
  Pituitary macroadenomas, even in the absence of chiasmal compression, may induce GCC and retinal nerve fibre layer thinning. SD-OCT may have a role in the early diagnosis and management of patients with pituitary tumours.
authors: Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, University of Naples'Federico II', Naples, Italy.
authors: G
authors: G
authors: Cennamo
authors: Coleman-Ios Medicina Futura Medical Center, Naples, Italy.
authors: R S
authors: RS
authors: Auriemma
authors: Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, University of Naples'Federico II', Naples, Italy.
authors: D
authors: D
authors: Cardone
authors: Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University of Naples'Federico II', Naples, Italy.
authors: L F S
authors: LF
authors: Grasso
authors: Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, University of Naples'Federico II', Naples, Italy.
authors: N
authors: N
authors: Velotti
authors: Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University of Naples'Federico II', Naples, Italy.
authors: C
authors: C
authors: Simeoli
authors: Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University of Naples'Federico II', Naples, Italy.
authors: C
authors: C
authors: Di Somma
authors: Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University of Naples'Federico II', Naples, Italy.
authors: R
authors: R
authors: Pivonello
authors: Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University of Naples'Federico II', Naples, Italy.
authors: A
authors: A
authors: Colao
authors: Dipartimento di Neuroscienze, Scienze Riproduttive ed Odontostomatologiche, University of Naples'Federico II', Naples, Italy.
authors: G
authors: G
authors: de Crecchio
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000175:diagnosis; D000328:Adult; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000150:complications*; D009412:Nerve Fibers / Q000473:pathology*; D009897:Optic Chiasm; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014065:Tonometry, Ocular; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology