title: Complexation of synthetic CDM-AM copolymer with natamycin and carbendazim to improve solubility and fungicidal activity.
abstract: The β-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and β-CD maleate (CDM) using K2S2O8 as initiator. The effects of the CDM-AM copolymer on the solubility and fungicidal activity of natamycin (NM) and carbendazim (MBC) were investigated. The stability constant of NM·CDM-AM and MBC·CDM-AM complexes at 303 K were of 10,725.45 M(-1) and 3000.89 M(-1), respectively. The complexes were characterized using phase solubility diagrams, NMR spectra and FT-IR spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone.
authors: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences, 100193 Beijing, China; Key Opening Laboratory of Agricultural Products Processing and Quality Control, Ministry of Agriculture, 100193 Beijing, China.
authors: Yong-Fu
authors: YF
authors: Li
authors: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences, 100193 Beijing, China; Key Opening Laboratory of Agricultural Products Processing and Quality Control, Ministry of Agriculture, 100193 Beijing, China.
authors: Jing
authors: J
authors: Jin
authors: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences, 100193 Beijing, China; Key Opening Laboratory of Agricultural Products Processing and Quality Control, Ministry of Agriculture, 100193 Beijing, China.
authors: Qin
authors: Q
authors: Guo
authors: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences, 100193 Beijing, China; Key Opening Laboratory of Agricultural Products Processing and Quality Control, Ministry of Agriculture, 100193 Beijing, China. Electronic address: hayiming@sina.com.
authors: Yi-Ming
authors: YM
authors: Ha
authors: Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences, 100193 Beijing, China; Key Opening Laboratory of Agricultural Products Processing and Quality Control, Ministry of Agriculture, 100193 Beijing, China.
authors: Qing-Peng
authors: QP
authors: Li
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology; D002219:Carbamates / Q000737:chemistry* / Q000494:pharmacology; D010866:Natamycin / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000138:chemical synthesis* / Q000494:pharmacology; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D001562:Benzimidazoles; D002219:Carbamates; D011108:Polymers; D047392:beta-Cyclodextrins; D020106:Acrylamide; D010866:Natamycin; C006698:carbendazim; C031215:betadex
keywords: Aspergillus niger; Carbendazim; Isothermal adsorption; Natamycin; Rheological properties; Solubility