title: State-of-the-art acute and chronic GVHD treatment.
abstract: Graft-versus-host disease (GVHD) remains as the major obstacle for successful hematopoietic stem cell transplant (HSCT). Roughly half of the patients undergoing HSCT develop GVHD which requires treatment, and above 10 % of the patient may die because of it. However, GVHD presents with anti-tumor activity, called graft-versus-tumor (GVT) effect, and it carries significant anti-tumor activity, thus suppressing GVHD completely may increase the relapse of original disease. Thus, it is important to control GVHD to the appropriate level.
authors: Division of Hematology and Oncology, University of Alabama at Birmingham (UAB), 1802 6th Ave South, NP 2562, Birmingham, AL, 35294-3300, USA.
authors: Muhammad Omer
authors: MO
authors: Jamil
authors: Shin
authors: S
authors: Mineishi
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D014184:Transplantation, Homologous / Q000009:adverse effects