title: Is there interaction between gut microbial profile and cardiovascular risk in chronic kidney disease patients?
abstract: OBJECTIVE
  To evaluate the gut microbial profile in chronic kidney disease (CKD) patients and evaluate the possible relationship with inflammation and cardiovascular risk.
  
  
  METHODS
  Markers inflammation plasma and bacterial community profile (denaturing gradient gel electrophoresis) were analyzed.
  
  
  RESULTS
  The average number of bands was not different in healthy individuals and CKD patients. The number of bands was negatively associated with plasma levels of VCAM-1 in patients. Flavobacteriaceae bacterium and Listeria monocytogenes were found in patients and Lachnospiraceae bacterium and Butyrivibrio crossotus in healthy individuals.
  
  
  CONCLUSIONS
  Although CKD patients did not present altered gut microbial profile, the sequencing of bands suggested a different microbiota between groups. The result suggests a possible relationship between gut microbiota and cardiovascular risk in CKD patients.
authors: Cardiovascular Sciences Graduate Program, Federal University Fluminense (UFF), Niterói-RJ, Brazil.
authors: Amanda F
authors: AF
authors: Barros
authors: Natália A
authors: NA
authors: Borges
authors: Dennis C
authors: DC
authors: Ferreira
authors: Flávia L
authors: FL
authors: Carmo
authors: Alexandre S
authors: AS
authors: Rosado
authors: Denis
authors: D
authors: Fouque
authors: Denise
authors: D
authors: Mafra
mesh_terms: D058448:Biota; D001774:Blood Chemical Analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D058645:Denaturing Gradient Gel Electrophoresis; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D018570:Risk Assessment; D017422:Sequence Analysis, DNA
keywords: cardiovascular diseases; chronic renal failure; gut microbiota; inflammation; oxidative stress