title: Control of response reliability by parvalbumin-expressing interneurons in visual cortex.
abstract: The responses of visual cortical neurons to natural stimuli are both reliable and sparse. These properties require inhibition, yet the contribution of specific types of inhibitory neurons is not well understood. Here we demonstrate that optogenetic suppression of parvalbumin (PV)- but not somatostatin (SOM)-expressing interneurons reduces response reliability in the primary visual cortex of anaesthetized and awake mice. PV suppression leads to increases in the low firing rates and decreases in the high firing rates of cortical neurons, resulting in an overall reduction of the signal-to-noise ratio (SNR). In contrast, SOM suppression generally increases the overall firing rate for most neurons, without affecting the SNR. Further analysis reveals that PV, but not SOM, suppression impairs neural discrimination of natural stimuli. Together, these results reveal a critical role for PV interneurons in the formation of reliable visual cortical representations of natural stimuli.
authors: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.
authors: Yingjie
authors: Y
authors: Zhu
authors: 1] Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China [2] University of Chinese Academy of Sciences, Shanghai, China.
authors: Wenhui
authors: W
authors: Qiao
authors: 1] Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China [2] University of Chinese Academy of Sciences, Shanghai, China.
authors: Kefei
authors: K
authors: Liu
authors: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.
authors: Huiyuan
authors: H
authors: Zhong
authors: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China.
authors: Haishan
authors: H
authors: Yao
mesh_terms: D000758:Anesthesia; D000818:Animals; D005074:Evoked Potentials, Visual / Q000235:genetics*; D015870:Gene Expression; D017930:Genes, Reporter; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D007395:Interneurons / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009433:Neural Inhibition / Q000235:genetics*; D062308:Optogenetics; D010320:Parvalbumins / Q000235:genetics* / Q000378:metabolism; D010775:Photic Stimulation; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D015203:Reproducibility of Results; D025604:Rhodopsins, Microbial / Q000235:genetics / Q000378:metabolism; D059629:Signal-To-Noise Ratio; D013004:Somatostatin / Q000235:genetics* / Q000378:metabolism; D009435:Synaptic Transmission / Q000235:genetics; D014793:Visual Cortex / Q000166:cytology / Q000378:metabolism*; D014851:Wakefulness / Q000502:physiology
chemical_list: D010320:Parvalbumins; D011993:Recombinant Fusion Proteins; D025604:Rhodopsins, Microbial; D049452:Green Fluorescent Proteins; D013004:Somatostatin