title: Atherosclerosis and the role of immune cells.
abstract: Atherosclerosis is a chronic inflammatory disease arising from lipids, specifically low-density lipoproteins, and leukocytes. Following the activation of endothelium with the expression of adhesion molecules and monocytes, inflammatory cytokines from macrophages, and plasmacytoid dendritic cells, high levels of interferon (IFN)-α and β are generated upon the activation of toll-like receptor-9, and T-cells, especially the ones with Th1 profile, produce pro-inflammatory mediators such as IFN-γ and upregulate macrophages to adhere to the endothelium and migrate into the intima. This review presents an exhaustive account for the role of immune cells in the atherosclerosis.
authors: Fulya Ilhan, Department of Immunology, Faculty of Medicine, University of Firat, 23200 Elazıg, Turkey.
authors: Fulya
authors: F
authors: Ilhan
authors: Fulya Ilhan, Department of Immunology, Faculty of Medicine, University of Firat, 23200 Elazıg, Turkey.
authors: Sevgi Tas
authors: ST
authors: Kalkanli
keywords: Adhesion molecules; Atherosclerosis; Immune cells; Inflammatory cytokines; Pro-inflammatory mediators