title: Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study.
abstract: Epilepsy is a common neurological disease characterized by recurrent unprovoked seizures. Evidence suggested that abnormal activity of brain-derived neurotrophic factor (BDNF) contributes to the pathogenesis of epilepsy. Some previous studies identified association between genetic variants of BDNF and risk of epilepsy. In this study, this association has been examined in the Hong Kong and Malaysian epilepsy cohorts. Genomic DNA of 6047 subjects (1640 patients with epilepsy and 4407 healthy individuals) was genotyped for rs6265, rs11030104, rs7103411, and rs7127507 polymorphisms by using Sequenom MassArray and Illumina HumanHap 610-Quad or 550-Duo BeadChip arrays techniques. Results showed significant association between rs6265 T, rs7103411 C, and rs7127507 T and cryptgenic epilepsy risk (p = 0.00003, p = 0.0002, and p = 0.002, respectively) or between rs6265 and rs7103411 and symptomatic epilepsy risk in Malaysian Indians (TT vs. CC, p = 0.004 and T vs. C, p = 0.0002, respectively) as well as between rs6265 T and risk of cryptogenic epilepsy in Malaysian Chinese (p = 0.005). The Trs6265-Crs7103411-Trs7127507 was significantly associated with cryptogenic epilepsy in Malaysian Indians (p = 0.00005). In conclusion, our results suggest that BDNF polymorphisms might contribute to the risk of epilepsy in Malaysian Indians and Chinese.
authors: Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Lembah Pantai, 59100, Kuala Lumpur, Malaysia.
authors: Hidayati Mohd
authors: HM
authors: Sha'ari
authors: Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Lembah Pantai, 59100, Kuala Lumpur, Malaysia. batoolsadat@yahoo.com.
authors: Batoul Sadat
authors: BS
authors: Haerian
authors: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong, China. lwbaum@hotmail.com.
authors: Larry
authors: L
authors: Baum
authors: Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors: Hui Jan
authors: HJ
authors: Tan
authors: Division of Neurology, General Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
authors: Mohd Hanip
authors: MH
authors: Rafia
authors: Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
authors: Patrick
authors: P
authors: Kwan
authors: Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors: Stacey S
authors: SS
authors: Cherny
authors: Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors: Pak Chung
authors: PC
authors: Sham
authors: Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong, China.
authors: Hongsheng
authors: H
authors: Gui
authors: Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors: Azman Ali
authors: AA
authors: Raymond
authors: Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors: Kheng Seang
authors: KS
authors: Lim
authors: Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Lembah Pantai, 59100, Kuala Lumpur, Malaysia.
authors: Zahurin
authors: Z
authors: Mohamed
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000737:chemistry / Q000235:genetics*; D016022:Case-Control Studies; D003710:Demography; D004827:Epilepsy / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006723:Hong Kong; D006801:Humans; D008296:Malaysia; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: BDNF; Epilepsy; Polymorphism; Susceptibility