title: Birth weight, current anthropometric markers, and high sensitivity C-reactive protein in Brazilian school children.
abstract: Studies have shown associations of birth weight with increased concentrations of high sensitivity C-reactive protein. This study assessed the relationship between birth weight, anthropometric and metabolic parameters during childhood, and high sensitivity C-reactive protein. A total of 612 Brazilian school children aged 5-13 years were included in the study. High sensitivity C-reactive protein was measured by particle-enhanced immunonephelometry. Nutritional status was assessed by body mass index, waist circumference, and skinfolds. Total cholesterol and fractions, triglycerides, and glucose were measured by enzymatic methods. Insulin sensitivity was determined by the homeostasis model assessment method. Statistical analysis included chi-square test, General Linear Model, and General Linear Model for Gamma Distribution. Body mass index, waist circumference, and skinfolds were directly associated with birth weight (P < 0.001, P = 0.001, and P = 0.015, resp.). Large for gestational age children showed higher high sensitivity C-reactive protein levels (P < 0.001) than small for gestational age. High birth weight is associated with higher levels of high sensitivity C-reactive protein, body mass index, waist circumference, and skinfolds. Large for gestational age altered high sensitivity C-reactive protein and promoted additional risk factor for atherosclerosis in these school children, independent of current nutritional status.
authors: Post-Graduation Program in Health Sciences-Cardiology, Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, RS, Brazil.
authors: Camile
authors: 0000-0002-6798-7212
authors: C
authors: Boscaini
authors: Post-Graduation Program in Health Sciences-Cardiology, Instituto de Cardiologia/Fundação Universitária de Cardiologia, Porto Alegre, RS, Brazil ; Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil ; Research Unit, Avenida Princesa Isabel 370, Santana, 90620-000 Porto Alegre, RS, Brazil.
authors: Lucia Campos
authors: LC
authors: Pellanda
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000453:epidemiology* / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D001823:Body Composition; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009752:Nutritional Status; D009765:Obesity / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D011237:Predictive Value of Tests; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol