title: A clinical and radiological objective tumor response with somatostatin analogs (SSA) in well-differentiated neuroendocrine metastatic tumor of the ileum: a case report.
abstract: Somatostatin analogs (SSAs) are typically used to treat the symptoms caused by neuroendocrine tumors (NETs), but they are not used as the primary treatment to induce tumor shrinkage. We report a case of a 63-year-old woman with a symptomatic metastatic NET of the ileum. Complete symptomatic response was achieved after 1 month of treatment with SSAs. In addition, there was an objective response in the liver, with the disappearance of secondary lesions noted on computed tomography scan after 3 months of octreotide treatment. Our experience suggests that SSAs could be useful for downstaging and/or downsizing well-differentiated NETs, and they could allow surgery to be performed. Such presurgery therapy could be a promising tool in the management of patients with initially inoperable NETs.
authors: Department of Abdominal Oncology, National Cancer Institute "Fondazione G. Pascale", Naples, Italy.
authors: Chiara
authors: C
authors: De Divitiis
authors: Department of Clinical Medicine and Surgery, "Federico II" University, Naples, Italy.
authors: Claudia
authors: C
authors: von Arx
authors: Department of Radiology, National Cancer Institute "Fondazione G Pascale", Naples, Italy.
authors: Roberto
authors: R
authors: Carbone
authors: Department of Pathology, National Cancer Institute "Fondazione G Pascale", Naples, Italy.
authors: Fabiana
authors: F
authors: Tatangelo
authors: Department of Endoscopy, National Cancer Institute "Fondazione G Pascale", Naples, Italy.
authors: Elena
authors: E
authors: Di Girolamo
authors: Department of Abdominal Oncology, National Cancer Institute "Fondazione G. Pascale", Naples, Italy.
authors: Giovanni Maria
authors: GM
authors: Romano
authors: Department of Abdominal Oncology, National Cancer Institute "Fondazione G. Pascale", Naples, Italy.
authors: Alessandro
authors: A
authors: Ottaiano
authors: Department of Radiology, National Cancer Institute "Fondazione G Pascale", Naples, Italy.
authors: Elisabetta
authors: E
authors: de Lutio di Castelguidone
authors: Department of Abdominal Oncology, National Cancer Institute "Fondazione G. Pascale", Naples, Italy.
authors: Rosario Vincenzo
authors: RV
authors: Iaffaioli
authors: Department of Abdominal Oncology, National Cancer Institute "Fondazione G. Pascale", Naples, Italy.
authors: Salvatore
authors: S
authors: Tafuto
keywords: metastatic tumor of the ileum; neuroendocrine tumor; octreotide; radiological tumor response; somatostatin analogs