title: Cis-encoded non-coding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens.
abstract: Due to recent advances of bioinformatics and high throughput sequencing technology, discovery of regulatory non-coding RNAs in bacteria has been increased to a great extent. Based on this bandwagon, many studies searching for trans-acting small non-coding RNAs in streptococci have been performed intensively, especially in the important human pathogen, group A and B streptococci. However, studies for cis-encoded non-coding antisense RNAs in streptococci have been scarce. A recent study shows antisense RNAs are involved in virulence gene regulation in group B streptococcus, S. agalactiae. This suggests antisense RNAs could have important roles in the pathogenesis of streptococcal pathogens. In this review, we describe recent discoveries of chromosomal cis-encoded antisense RNAs in streptococcal pathogens and other low GC Gram (+) bacteria to provide a guide for future studies.
authors: Department of Biology, Indiana State University Terre Haute, IN, USA.
authors: Kyu Hong
authors: KH
authors: Cho
authors: Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Science Washington, DC, USA.
authors: Jeong-Ho
authors: JH
authors: Kim
keywords: Gram (+) pathogens; antisense RNAs; non-coding RNAs; regulatory RNAs; streptococci