title: The zDHHC family of S-acyltransferases.
abstract: The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.
authors: *Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.
authors: Kimon
authors: K
authors: Lemonidis
authors: *Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.
authors: Martin W
authors: MW
authors: Werno
authors: *Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.
authors: Jennifer
authors: J
authors: Greaves
authors: *Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.
authors: Cinta
authors: C
authors: Diez-Ardanuy
authors: *Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.
authors: Maria C
authors: MC
authors: Sanchez-Perez
authors: *Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.
authors: Christine
authors: C
authors: Salaun
authors: *Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.
authors: David M
authors: DM
authors: Thomson
authors: *Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.
authors: Luke H
authors: LH
authors: Chamberlain
mesh_terms: D000215:Acylation / Q000235:genetics*; D000217:Acyltransferases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D005810:Multigene Family / Q000235:genetics; D013379:Substrate Specificity
chemical_list: D000217:Acyltransferases; C486179:ZDHHC1 protein, human