title: Comparison of the new risk prediction model (HCM Risk-SCD) and classic risk factors for sudden death in patients with hypertrophic cardiomyopathy and defibrillator.
abstract: OBJECTIVE
  Hypertrophic cardiomyopathy is one of the main causes of sudden death in young people. Recent clinical practice guidelines include a risk prediction model for sudden death (HCM Risk-SCD), which facilitates the decision of whether to implant a defibrillator. The aim of our study was to ascertain the percentage of events in our series of primary prevention implantable cardioverter-defibrillator recipients with hypertrophic cardiomyopathy and whether HCM Risk-SCD predicts the onset of arrhythmic events.
  
  
  RESULTS
  This was an observational, retrospective cohort study, which included 48 primary prevention defibrillator recipient patients with HCM. We compiled their demographic and clinical characteristics, estimated 5-year risk using HCM Risk-SCD, and collected the documentation on arrhythmias during follow-up. The majority was male (66.7%) and mean age at implantation was 44.44 ± 14.46 years. Non-sustained ventricular tachycardia was the most prevalent risk factor (66.67%), followed by a family history of sudden death (47.92%). Mean HCM Risk-SCD was 6.15 ± 5.01%. HCM Risk-SCD was the only factor independently associated with the onset of ventricular tachyarrhythmia, above any other classic risk factor or association [odds ratio = 1.46 (95% confidence interval 1.051-2.013); P = 0.02]. None of the 11 patients estimated as low risk using HCM Risk-SCD suffered any appropriate events (P < 0.05).
  
  
  CONCLUSIONS
  During an average follow-up of 4 years, 16.67% presented appropriate events (4.16%/year). HCM Risk-SCD predicted the onset of events more suitably than classic risk factors.
authors: Hospital Universitario Virgen de la Victoria, Málaga, Spain amalio_ruiz@hotmail.com.
authors: Amalio
authors: A
authors: Ruiz-Salas
authors: Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors: Jose Manuel
authors: JM
authors: García-Pinilla
authors: Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors: Fernando
authors: F
authors: Cabrera-Bueno
authors: Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors: Julia
authors: J
authors: Fernández-Pastor
authors: Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors: José
authors: J
authors: Peña-Hernández
authors: Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors: Carmen
authors: C
authors: Medina-Palomo
authors: Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors: Alberto
authors: A
authors: Barrera-Cordero
authors: Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors: Eduardo
authors: E
authors: De Teresa
authors: Hospital Universitario Virgen de la Victoria, Málaga, Spain.
authors: Javier
authors: J
authors: Alzueta
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000453:epidemiology* / Q000517:prevention & control; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000628:therapy*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology* / Q000517:prevention & control; D017147:Defibrillators, Implantable; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011322:Primary Prevention / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors; D013030:Spain
keywords: Defibrillator; Hypertrophic cardiomyopathy; Sudden death