title: Pulmonary delivery of anorectic oxyntomodulin in rats: food intake suppression, reduced body weight gain and pharmacokinetics.
abstract: BACKGROUND
  Oxyntomodulin (OXM1-37) is an anorectic gut-secreting peptide with a promise to treat obesity, but its needle-free delivery has yet to be successful.
  
  
  RESULTS
  Pulmonary delivery of OXM1-37, but not its C-terminal octapeptides, caused dose-related, transient 4-6 h food intake suppression in rats. At 0.5 mg/kg, its 30-38% food intake suppression led to 46% reduction in body weight gain by day 8. Its lung absorption was fast, elevating the systemic level rapidly, yet the bioavailability was low at 13%. In the brain, twofold neuronal c-fos activation was seen in the hypothalamus arcuate nucleus and brainstem area postrema.
  
  
  CONCLUSIONS
  Pulmonary delivery is a promising needle-free systemic delivery option for OXM1-37 to treat obesity, as enabling effective lung absorption and brain interaction.
authors: Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, 410 N. 12th Street, P.O. Box 980533, Richmond, VA 23298, USA.
authors: Priya P
authors: PP
authors: Nadkarni
authors: Matthew S
authors: MS
authors: Halquist
authors: H Thomas
authors: HT
authors: Karnes
authors: Richard M
authors: RM
authors: Costanzo
authors: Masahiro
authors: M
authors: Sakagami
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001921:Brain / Q000378:metabolism; D016503:Drug Delivery Systems; D004435:Eating / Q000187:drug effects*; D008168:Lung / Q000378:metabolism*; D008297:Male; D053772:Oxyntomodulin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D015430:Weight Gain / Q000187:drug effects*
chemical_list: D001067:Appetite Depressants; D053772:Oxyntomodulin