title: Benefits and drawbacks of open partial horizontal laryngectomies, Part B: Intermediate and selected advanced stage laryngeal carcinoma.
abstract: Cancer of the larynx in the intermediate/advanced stage still presents a major challenge in terms of controlling the disease and preserving the organ. Among therapeutic options, open partial horizontal laryngectomy is proposed as a function-sparing surgical technique.
  
  
  
  We analyzed the clinical outcomes of 555 patients with laryngeal cancer staged pT3 to pT4a who underwent open partial horizontal laryngectomy.
  
  
  
  Five-year overall survival (OS), disease-free survival (DFS), locoregional control, local control, laryngectomy-free survival, and laryngeal function preservation rates were 84.6%, 84.2%, 86.3%, 90.6%, 93.3%, and 91.2%, respectively. DFS, locoregional control, and laryngeal function preservation rates were significantly affected by pT4a staging (68.1%, 71.7%, and 78.0%, respectively), whereas pN+ influenced only DFS (≤72.6%) and locoregional control (≤79.6%).
  
  
  
  Open partial horizontal laryngectomy with a modular approach can be considered effective in terms of prognostic and functional results in intermediate-stage and selected advanced-stage laryngeal cancers, even with subglottic extension. © 2015 Wiley Periodicals, Inc. Head Neck 38: E649-E657, 2016.
authors: Otorhinolaryngology Service, Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, Turin, Italy.
authors: Giovanni
authors: G
authors: Succo
authors: Otorhinolaryngology Service, Martini Hospital, Turin, Italy.
authors: Erika
authors: E
authors: Crosetti
authors: Otorhinolaryngology Service, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy.
authors: Andy
authors: A
authors: Bertolin
authors: Otorhinolaryngology Service, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy.
authors: Marco
authors: M
authors: Lucioni
authors: Otorhinolaryngology Service, Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, Turin, Italy.
authors: Giulia
authors: G
authors: Arrigoni
authors: L'altrastatistica srl, Consultancy and Training, Biostatistics Office, Rome, Italy.
authors: Valentina
authors: V
authors: Panetta
authors: Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
authors: Andrea E
authors: AE
authors: Sprio
authors: Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
authors: Giovanni N
authors: GN
authors: Berta
authors: Otorhinolaryngology Service, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy.
authors: Giuseppe
authors: G
authors: Rizzotto
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
keywords: laryngeal cancer; laryngeal function-sparing protocol; open partial laryngectomy; supracricoid partial laryngectomy; supratracheal partial laryngectomy