title: The anxiolytic effect of midazolam in third molar extraction: a systematic review.
abstract: OBJECTIVE
  To assess the efficacy of midazolam for anxiety control in third molar extraction surgery.
  
  
  METHODS
  Electronic retrievals were conducted in Medline (via PubMed, 1950-2013.12), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2013, Issue 3), Embase (via OVID 1974-2013.12), and the System for Information on Grey Literature in Europe (SIGLE). The bibliographies of relevant clinical trials were also checked. Randomized controlled trials satisfying the inclusion criteria were evaluated, with data extraction done independently by two well-trained investigators. Disagreements were resolved by discussion or by consultation with a third member of the review team.
  
  
  RESULTS
  Ten studies were included, but meta-analysis could not be conducted because of the significant differences among articles. All but one article demonstrated that midazolam could relieve anxiety. One article demonstrated that propofol offered superior anxiolysis, with more rapid recovery than with midazolam. Compared with lorazepam and diazepam, midazolam did not distinctly dominate in its sedative effect, but was safer. Two articles used midazolam in multidrug intravenous sedation and proved it to be more effective than midazolam alone.
  
  
  CONCLUSIONS
  It was found, by comparison and analysis, that midazolam might be effective for use for anxiety control during third molar extraction and can be safely administered by a dedicated staff member. It can also be used with other drugs to obtain better sedative effects, but the patient's respiratory function must be monitored closely, because multidrug sedation is also more risky.
authors: State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Stomatology Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Qi
authors: Q
authors: Chen
authors: State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Stomatology Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Lufei
authors: L
authors: Wang
authors: State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Stomatology Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Lina
authors: L
authors: Ge
authors: State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Stomatology Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Yuan
authors: Y
authors: Gao
authors: State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Stomatology Hospital, Sichuan University, Chengdu, Sichuan, China.
authors: Hang
authors: H
authors: Wang
mesh_terms: D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000209:etiology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D016239:MEDLINE; D008297:Male; D008874:Midazolam / Q000627:therapeutic use*; D008963:Molar; D014081:Tooth Extraction
chemical_list: D014151:Anti-Anxiety Agents; D008874:Midazolam