title: Normal "high" thyroid stimulating hormone (TSH) levels and pregnancy rates in patients undergoing IVF with donor eggs.
abstract: OBJECTIVE
  To determine if a relationship exists between pregnancy rates obtained in patients undergoing in vitro fertilization (lVF) with donor eggs and levels of thyroid stimulating hormone greater than 2.5 mlU/L but still within a range considered normal.
  
  
  METHODS
  Retrospective comparative cohort study. With prior approval of the Ethics Committee, 233 patients undergoing IVF with donor eggs, in a two-year period, were included. Patients were grouped depending on the thyroid stimulating hormone (TSH) level. Pregnancy rates were compared. Statistical analysis was made with the Chi-square test.
  
  
  RESULTS
  Pregnancy rates, depending on the TSH level, were 56.6% in patients with TSH levels below 2.49 mU/L vs. 21.6%, in patients with levels above 2.5 mU/L. This difference was statistically significant (p < 0.001).
  
  
  CONCLUSIONS
  Mild abnormalities of thyroid function may adversely affect the pregnancy rates in patients un- dergoing in vitro fertilization with donor eggs. A possible alteration in endometrial function may be associated.
authors: L H
authors: LH
authors: Sordia-Hernandez
authors: A
authors: A
authors: Morales Martinez
authors: J M
authors: JM
authors: Gris
authors: J
authors: J
authors: Herrero
authors: C
authors: C
authors: Hernandez Uzcanga
authors: M
authors: M
authors: Merino
authors: O
authors: O
authors: Valdes
authors: G
authors: G
authors: Guerrero
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends*; D012189:Retrospective Studies; D013030:Spain; D013972:Thyrotropin / Q000097:blood*; D009927:Tissue and Organ Procurement / Q000379:methods*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D013972:Thyrotropin