title: A case of hypersensitivity to soluble and isophane insulins but not to insulin glargine.
abstract: Insulin is an important agent for the treatment of diabetes mellitus (DM). Allergic reactions to insulin therapy, although rare, have been evident since animal insulin became available for the treatment of DM in 1922. Hypersensitivity to insulin has considerably been reduced with the introduction of human insulin produced by recombinant deoxyribonucleic acid technology. Here, we present a case of Type 2 DM who demonstrated immediate (Type 1) hypersensitivity reaction on the sites of subcutaneous injection of soluble and isophane insulin but insulin glargine was tolerated well and provided good glycemic control.
authors: Department of Clinical Pharmacology, T. N. Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.
authors: Mahesh N
authors: MN
authors: Belhekar
authors: Department of Clinical Pharmacology, T. N. Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.
authors: Sarayu
authors: S
authors: Pai
authors: Department of Endocrinology, T. N. Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.
authors: Parimal
authors: P
authors: Tayade
authors: Department of Endocrinology, T. N. Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.
authors: Pradip
authors: P
authors: Dalwadi
authors: Department of Clinical Pharmacology, T. N. Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.
authors: Renuka
authors: R
authors: Munshi
authors: Department of Endocrinology, T. N. Medical College and B. Y. L. Nair Charitable Hospital, Mumbai, Maharashtra, India.
authors: Prema
authors: P
authors: Varthakavi
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000139:chemically induced* / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood; D000069036:Insulin Glargine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D007336:Insulin, Isophane / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D061389:Insulin, Regular, Pork / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D061389:Insulin, Regular, Pork; D000069036:Insulin Glargine; D007073:Immunoglobulin E; D007336:Insulin, Isophane; C000006:insulin, neutral
keywords: Allergic reaction; diabetes mellitus; hypersensitivity; insulin