title: Effects of isotretinoin on the inflammatory markers and the platelet counts in patients with acne vulgaris.
abstract: OBJECTIVE
  Oral isotretinoin is an efficient treatment used commonly in treating the moderate and severe acne. It has various side effects that affect many systems in the body. In this study, we are planning to examine the possible effects of the oral isotretinoin on platelet density, mean platelet volume, neutrophil lymphocyte rate, platelet lymphocyte rate, and red-blood-cell distribution width level.
  
  
  METHODS
  Twenty-eight males and 84 females, 112 patients in total, diagnosed with acne vulgaris and receiving oral isotretinoin treatment were examined retrospectively. The full blood parameters of the patients before the treatment and in the third month of the treatment were recorded.
  
  
  RESULTS
  A statistically meaningful increase was observed in the platelet density, hemoglobin levels. And a statistically significant decrease has been determined in the red-blood-cell distribution width level while no meaningful differences were detected in the mean platelet volume, neutrophil lymphocyte rate, platelet lymphocyte rate, and white blood cell count.
  
  
  CONCLUSIONS
  The oral isotretinoin treatment has been demonstrated as having increased the platelet density, hemoglobin levels and having decreased red-blood-cell distribution width level significantly.
authors: a Department of Dermatology , School of Medicine, Gaziosmanpasa University , Tokat , Turkey and.
authors: Havva Yıldız
authors: HY
authors: Seçkin
authors: a Department of Dermatology , School of Medicine, Gaziosmanpasa University , Tokat , Turkey and.
authors: Yalçın
authors: Y
authors: Baş
authors: a Department of Dermatology , School of Medicine, Gaziosmanpasa University , Tokat , Turkey and.
authors: Zennure
authors: Z
authors: Takçı
authors: b Faculty of Medicine, Department of Dermatology , Yıldırım Beyazıt University , Ankara , Turkey.
authors: Göknur
authors: G
authors: Kalkan
mesh_terms: D000152:Acne Vulgaris / Q000097:blood / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects; D003879:Dermatologic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010976:Platelet Count; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D006454:Hemoglobins; D015474:Isotretinoin
keywords: Acne; inflammatory markers; isotretinoin