title: Pd(II)-catalyzed C(sp(3))-H arylation of amino acid derivatives with click-triazoles as removable directing groups.
abstract: By using click-triazoles as conveniently approachable and removable directing groups, the direct palladium-catalyzed C(sp(3))-H arylation of amino acid derivatives with various aryl iodides bearing different electronic properties has been achieved. Notably, the desired amino acid molecule can be obtained by the cleavage of the tethered click-triazoles after the catalytic reaction, which aims to provide a practical protocol for the accessibility of both natural and synthetic amino acids.
authors: College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China. dingcr@zjut.edu.cn.
authors: Guofu
authors: G
authors: Zhang
authors: Xiaoqiang
authors: X
authors: Xie
authors: Jianfei
authors: J
authors: Zhu
authors: Shasha
authors: S
authors: Li
authors: Chengrong
authors: C
authors: Ding
authors: Ping
authors: P
authors: Ding
mesh_terms: D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D057930:Click Chemistry / Q000379:methods*; D007454:Iodides / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D014230:Triazoles / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated
chemical_list: D000577:Amides; D000596:Amino Acids; D007454:Iodides; D010165:Palladium; D020005:Propanols; D014230:Triazoles; C001337:hexafluoroisopropanol; D006845:Hydrocarbons, Fluorinated