title: Time trends in incidence and case fatality of ischemic stroke: the tromsø study 1977-2010.
abstract: OBJECTIVE
  Ischemic stroke incidence has declined in industrialized countries the last decades, with possible exception for the youngest age groups. We estimated age- and sex-specific trends in incidence and case fatality of first-ever ischemic stroke between 1977 and 2010 in a Norwegian municipality.
  
  
  METHODS
  Age-adjusted time trends in incidence from 1977 to 2010 were estimated by fractional polynomial and Poisson regression, and case fatality by logistic regression in 36 575 participants of the population-based Tromsø Study.
  
  
  RESULTS
  There were 1214 first-ever ischemic strokes within a total follow-up time of 611 176 person-years. The overall age- and sex-adjusted incidence decreased by 24% in 1995 to 2010. In women aged 30 to 49 years, the incidence increased significantly from 1980 to 2010. In men aged 30 to 49 years, there was a nonsignificant, rising trend from 1977 to 2010. Men aged 50 to 64 years had similar incidence in 2010 compared with 1989. From the mid-1990s to 2010, the incidence declined significantly in women aged 50 to 74 years and in men aged 65 to 74 years, but remained stable in those aged ≥75 years. Case fatality decreased significantly in men aged 30 to 84 years from 1995 to 2010, whereas there was no significant change in women.
  
  
  CONCLUSIONS
  Age-adjusted incidence of first-ever ischemic stroke increased in young women, declined in women aged 50 to 74 years and men aged 65 to 74 years and remained stable among the oldest. Case fatality declined in men aged 30 to 84 years, but not in women.
authors: From the Department of Clinical Medicine (A.M.V.-L., S.H.J., M.C., E.B.M.), and Department of Community Medicine (T.W.), UiT The Arctic University of Norway, Tromsø, Norway; Department of Neurology, Innlandet Hospital Trust, Norway (A.M.V.-L.); Department of Neurology and Clinical Neurophysiology, University Hospital of North Norway, Norway (S.H.J., E.B.M.); and Department of Neurology, Nordland Hospital Trust, Bodø, Norway (M.C.). am.vanglon@gmail.com.
authors: Anne Merete
authors: AM
authors: Vangen-Lønne
authors: From the Department of Clinical Medicine (A.M.V.-L., S.H.J., M.C., E.B.M.), and Department of Community Medicine (T.W.), UiT The Arctic University of Norway, Tromsø, Norway; Department of Neurology, Innlandet Hospital Trust, Norway (A.M.V.-L.); Department of Neurology and Clinical Neurophysiology, University Hospital of North Norway, Norway (S.H.J., E.B.M.); and Department of Neurology, Nordland Hospital Trust, Bodø, Norway (M.C.).
authors: Tom
authors: T
authors: Wilsgaard
authors: From the Department of Clinical Medicine (A.M.V.-L., S.H.J., M.C., E.B.M.), and Department of Community Medicine (T.W.), UiT The Arctic University of Norway, Tromsø, Norway; Department of Neurology, Innlandet Hospital Trust, Norway (A.M.V.-L.); Department of Neurology and Clinical Neurophysiology, University Hospital of North Norway, Norway (S.H.J., E.B.M.); and Department of Neurology, Nordland Hospital Trust, Bodø, Norway (M.C.).
authors: Stein Harald
authors: SH
authors: Johnsen
authors: From the Department of Clinical Medicine (A.M.V.-L., S.H.J., M.C., E.B.M.), and Department of Community Medicine (T.W.), UiT The Arctic University of Norway, Tromsø, Norway; Department of Neurology, Innlandet Hospital Trust, Norway (A.M.V.-L.); Department of Neurology and Clinical Neurophysiology, University Hospital of North Norway, Norway (S.H.J., E.B.M.); and Department of Neurology, Nordland Hospital Trust, Bodø, Norway (M.C.).
authors: Maria
authors: M
authors: Carlsson
authors: From the Department of Clinical Medicine (A.M.V.-L., S.H.J., M.C., E.B.M.), and Department of Community Medicine (T.W.), UiT The Arctic University of Norway, Tromsø, Norway; Department of Neurology, Innlandet Hospital Trust, Norway (A.M.V.-L.); Department of Neurology and Clinical Neurophysiology, University Hospital of North Norway, Norway (S.H.J., E.B.M.); and Department of Neurology, Nordland Hospital Trust, Bodø, Norway (M.C.).
authors: Ellisiv B
authors: EB
authors: Mathiesen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000453:epidemiology* / Q000401:mortality*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D011446:Prospective Studies; D012044:Regression Analysis; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology* / Q000401:mortality*; D014505:Urban Population
keywords: case fatality; cerebral infarction incidence; cohort study; epidemiology; stroke