title: Cell-based screening: extracting meaning from complex data.
abstract: Unbiased discovery approaches have the potential to uncover neurobiological insights into CNS disease and lead to the development of therapies. Here, we review lessons learned from imaging-based screening approaches and recent advances in these areas, including powerful new computational tools to synthesize complex data into more useful knowledge that can reliably guide future research and development.
authors: Director of the Taube/Koret Center for Neurodegenerative Disease and the Hellman Family Foundation Program in Alzheimer's Disease Research, Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: sfinkbeiner@gladstone.ucsf.edu.
authors: Steven
authors: S
authors: Finkbeiner
authors: Director of Engineering, Research, Google, Inc., 1600 Amphitheatre Parkway, Mountain View, CA 94043, USA.
authors: Michael
authors: M
authors: Frumkin
authors: Director of Research, Amgen, Inc., 1120 Veterans Boulevard South, San Francisco, CA 94080, USA.
authors: Paul D
authors: PD
authors: Kassner
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000628:therapy; D003198:Computer Simulation; D016208:Databases, Factual; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology*; D012106:Research