title: Dissecting the role of curcumin in tumour growth and angiogenesis in mouse model of human breast cancer.
abstract: Breast cancer is considered the most common cancer for women worldwide and it is now the second leading cause of cancer-related deaths among females in the world. Since breast cancer is highly resistant to chemotherapy, alternative anticancer strategies have been developed. In particular, many studies have demonstrated that curcumin, a derivative of turmeric, can be used as natural agent in treatment of some types of cancer by playing antiproliferative and antioxidant effects. In our study, we assessed the antitumor activities of curcumin in ER-negative human breast cancer cell line resistant to chemotherapy, MDA.MB231 by in vitro and in vivo experiments. In vitro data allowed us to demonstrate that curcumin played a role in regulation of proliferation and apoptosis in MDA.MB231 cells. In vivo, by generation of mouse model of breast cancer, we showed that treatment of curcumin inhibited tumor growth and angiogenesis. Specifically, we showed that curcumin is able to deregulate the expression of cyclin D1, PECAM-1, and p65, which are regulated by NF-κB. Our data demonstrated that curcumin could be used as an adjuvant agent to chemotherapy in treatment of triple negative breast cancer.
authors: Hepatobiliary Unit, Istituto Nazionale per la Studio e la Cura dei Tumori "Fondazione G. Pascale" (IRCCS), Via Mariano Semmola, 80131 Naples, Italy.
authors: Sabrina
authors: S
authors: Bimonte
authors: S.S.D. Sperimentazione Animale, Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione G. Pascale" (IRCCS), Via Mariano Semmola, 80131 Naples, Italy.
authors: Antonio
authors: A
authors: Barbieri
authors: S.S.D. Sperimentazione Animale, Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione G. Pascale" (IRCCS), Via Mariano Semmola, 80131 Naples, Italy ; Istituto di Endocrinologia e Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c/o, Dipartimento di Biologia e Patologia Cellulare e Molecolare "L. Califano", Università degli Studi di Napoli "Federico II", Via Pansini 5, 80131 Naples, Italy.
authors: Giuseppe
authors: G
authors: Palma
authors: Hepatobiliary Unit, Istituto Nazionale per la Studio e la Cura dei Tumori "Fondazione G. Pascale" (IRCCS), Via Mariano Semmola, 80131 Naples, Italy.
authors: Domenica
authors: 0000-0002-7162-6735
authors: D
authors: Rea
authors: Hepatobiliary Unit, Istituto Nazionale per la Studio e la Cura dei Tumori "Fondazione G. Pascale" (IRCCS), Via Mariano Semmola, 80131 Naples, Italy.
authors: Antonio
authors: A
authors: Luciano
authors: Division of Breast Surgery, Department of Breast Disease, Istituto dei Tumori di Napoli "Fondazione G. Pascale" (IRCCS), 80131 Naples, Italy.
authors: Massimiliano
authors: M
authors: D'Aiuto
authors: S.S.D. Sperimentazione Animale, Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione G. Pascale" (IRCCS), Via Mariano Semmola, 80131 Naples, Italy.
authors: Claudio
authors: C
authors: Arra
authors: Hepatobiliary Unit, Istituto Nazionale per la Studio e la Cura dei Tumori "Fondazione G. Pascale" (IRCCS), Via Mariano Semmola, 80131 Naples, Italy.
authors: Francesco
authors: F
authors: Izzo
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage*; D019938:Cyclin D1 / Q000096:biosynthesis / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000235:genetics; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000096:biosynthesis* / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D064726:Triple Negative Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D023041:Xenograft Model Antitumor Assays
chemical_list: C530104:CCND1 protein, human; D016328:NF-kappa B; D019938:Cyclin D1; D003474:Curcumin