title: Cholesterol, statins, and dementia: what the cardiologist should know.
abstract: Alzheimer dementia (AD) is an important clinical problem that appears to be closely tied to comorbid cardiovascular disease, making it a relevant topic for the clinical cardiologist. Determinants of cardiovascular health, especially midlife dyslipidemia, are associated with an increased risk of dementia based on molecular and epidemiologic data. Given the potential role of dyslipidemia in the development of dementia, statins have been investigated as potential therapeutic options to slow or prevent disease. This review discusses the role of dyslipidemia and other cardiovascular risk factors in the pathogenesis of AD, with a focus on the existing evidence for the use of statin medications in the treatment and prevention of AD from observational studies and randomized clinical trials. Clinical questions for the practicing cardiologist are addressed.
authors: Department of Medicine, Division of Cardiology, The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, Maryland.
authors: Brett L
authors: BL
authors: Wanamaker
authors: Kristopher J
authors: KJ
authors: Swiger
authors: Roger S
authors: RS
authors: Blumenthal
authors: Seth S
authors: SS
authors: Martin
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000517:prevention & control*; D002318:Cardiovascular Diseases / Q000150:complications / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood*; D015897:Comorbidity; D050171:Dyslipidemias / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D012306:Risk
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol