title: The relationship between visfatin, liver inflammation, and acute phase reactants in chronic viral hepatitis B.
abstract: Chronic viral hepatitis B (CHB) is an important cause of morbidity and mortality. Adipokine stimulation might play an important role in the pathogenesis of chronic inflammation. The aim of this study was to evaluate serum visfatin concentrations and the relationship between visfatin, fibrosis, liver inflammation, and acute phase reactants in CHB patients.The sampling universe of the study consisted of 41 CHB patients and 25 healthy controls. All patients had positive hepatitis B surface antigen (Hepatitis e antigen (HBeAg) positive n: 7, n: 34 HBeAg negative) for at least 6 months and detectable serum HBV DNA. Serum visfatin concentrations were significantly higher in the CHB patients [18.0 ± 10.9 ng dL(-1)] than in the healthy controls [9.4 ± 1.6 ng dL(-1)] [P < 0.001]. On the other hand, fibrinogen and haptoglobin concentrations were significantly lower in CHB patients. A strong negative correlation was observed between serum visfatin concentration, haptoglobin, and fibrinogen levels; however, there was no significant correlation between visfatin, glucose, alanine aminotransferase, aspartate aminotransferase, BMI, Knodell score, fibrosis score, hepatitis B virus DNA, sedimentation, and C-reactive protein. Visfatin concentrations were elevated and visfatin was negatively correlated with haptoglobin and fibrinogen levels in CHB patients.
authors: Deparment of Internal Medicine, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Enver
authors: E
authors: Yüksel
authors: Department of Gastroenterology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors: Erdem
authors: E
authors: Akbal
authors: Department of Gastroenterology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Erdem
authors: E
authors: Koçak
authors: Department of Internal Medicine, Mevlana University Faculty of Medicine, Konya, Turkey. dromerakyurek@gmail.com.
authors: Ömer
authors: Ö
authors: Akyürek
authors: Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors: Seyfettin
authors: S
authors: Köklü
authors: Department of Gastroenterology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.
authors: Fuat
authors: F
authors: Ekiz
authors: Department of Gastroenterology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey.
authors: Barış
authors: B
authors: Yılmaz
mesh_terms: D000209:Acute-Phase Proteins / Q000276:immunology*; D000328:Adult; D016207:Cytokines / Q000097:blood / Q000276:immunology*; D005260:Female; D019694:Hepatitis B, Chronic / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood / Q000276:immunology*; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood / Q000276:immunology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D000209:Acute-Phase Proteins; D016207:Cytokines; D018836:Inflammation Mediators; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human
keywords: Chronic hepatitis B; Fibrinogen; Haptoglobin; Visfatin