title: Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.
abstract: Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp(3) carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.
authors: Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. scseigyo-hisyo@pharm.kyoto-u.ac.jp.
authors: Shan
authors: S
authors: Lu
authors: Shinichi
authors: S
authors: Nishimura
authors: Go
authors: G
authors: Hirai
authors: Masashi
authors: M
authors: Ito
authors: Teppei
authors: T
authors: Kawahara
authors: Miho
authors: M
authors: Izumikawa
authors: Mikiko
authors: M
authors: Sodeoka
authors: Kazuo
authors: K
authors: Shin-ya
authors: Toshio
authors: T
authors: Tsuchida
authors: Hideaki
authors: H
authors: Kakeya
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008968:Molecular Conformation; D011789:Quantum Theory; D013329:Structure-Activity Relationship
chemical_list: D018942:Macrolides; C000604796:saccharothriolide B