title: Quantitative 31P-NMR spectroscopy for the determination of fosfomycin and impurity A in pharmaceutical products of fosfomycin sodium or calcium.
abstract: A quantitative 31P-NMR method for the determination of fosfomycin and impurity A in pharmaceutical products of fosfomycin sodium or calcium has been developed. In this method, coaxial inserts containing trimethyl phosphate are used as external standard. The method is convenient and robust, and gives both high accuracy and precision. It is shown that an accurate determination is possible using different probes and coaxial inserts.
authors: Center of Analysis and Test, Wuhan Institute of Technology, Wuhan, 430073, China.
authors: Haipeng
authors: H
authors: Jiang
authors: School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430073, China.
authors: Hong
authors: H
authors: Chen
authors: School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430073, China.
authors: Nian
authors: N
authors: Cai
authors: Center of Analysis and Test, Wuhan Institute of Technology, Wuhan, 430073, China.
authors: Jing
authors: J
authors: Zou
authors: School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430073, China.
authors: Xiulian
authors: X
authors: Ju
mesh_terms: D002118:Calcium / Q000737:chemistry*; D005578:Fosfomycin / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010759:Phosphorus Isotopes; D012964:Sodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004364:Pharmaceutical Preparations; D010759:Phosphorus Isotopes; D005578:Fosfomycin; D012964:Sodium; D002118:Calcium
keywords: NMR; coaxial insert; fosfomycin; quantitative 31P-NMR