title: [High-grade prostatic intraepithelial neoplasia: state-of-the-art].
abstract: According to current views, high-grade prostatic intraepithelial neoplasia is the most likely precursor of prostate adenocarcinoma. This review gives the latest data of genetic, proteomic, and morphological analyses of this neoplasia and touches upon the probems that might arise when searching for new markers for differential diagnosis and prognosis estimation.
authors: Russian Medical Academy of Postgraduate Education.
authors: D O
authors: DO
authors: Allina
authors: Russian Medical Academy of Postgraduate Education.
authors: Yu Yu
authors: YY
authors: Andreeva
authors: Russian Medical Academy of Postgraduate Education.
authors: L E
authors: LE
authors: Zavalishina
authors: Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow.
authors: T V
authors: TV
authors: Kekeeva
authors: Russian Medical Academy of Postgraduate Education.
authors: G A
authors: GA
authors: Frank
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D001707:Biopsy, Needle; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D009363:Neoplasm Proteins / Q000096:biosynthesis; D011379:Prognosis; D019048:Prostatic Intraepithelial Neoplasia / Q000235:genetics / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology*; D040901:Proteomics; D012307:Risk Factors
chemical_list: D009363:Neoplasm Proteins