title: Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma.
abstract: Pancreatic ductal adenocarcinoma (PDAC) is charac-terized by a poor prognosis and high mortality rate. In this study, we investigated the expression of Rab23 in non-tumor pancreatic tissues and PDACs via immunohistochemistry. Rab23 was found in 39 of 58 (67.2%) and in 11 of 30 (36.7%) of the PDAC and non-tumor pan-creatic tissue samples (P = 0.0073), respectively. There were signifi-cant correlations between Rab23 expression and unfavorable variables, including cancer differentiation level (P = 0.0089), lymph nodal (P = 0.0099), and distant metastases (P = 0.0173). Inactivation with small interfering RNA against Rab23 in the human pancreatic cancer cell line Panc-1 inhibited the migration and invasive potential of the cells. Our data provide new insight into the essential role of Rab23 in PDAC inva-sion and metastasis and suggest that Rab23 expression is a useful indi-cator of metastatic potential; hence, it may be a new therapeutic target for this common malignancy.
authors: Department of Gastroenterology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors: Z Z
authors: ZZ
authors: Cai
authors: Department of General Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors: L B
authors: LB
authors: Xu
authors: Department of General Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China jinglicai@hotmail.com.
authors: J L
authors: JL
authors: Cai
authors: Department of General Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors: J S
authors: JS
authors: Wang
authors: Department of General Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors: B
authors: B
authors: Zhou
authors: Department of General Surgery, East Hospital Tongji University School of Medicine, Shanghai, China.
authors: H
authors: H
authors: Hu
mesh_terms: D015153:Blotting, Western; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D002465:Cell Movement / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D034622:RNA Interference; D020133:Reverse Transcriptase Polymerase Chain Reaction; D020691:rab GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: C486614:RAB23 protein, human; D020691:rab GTP-Binding Proteins