title: Highly chemoselective and versatile method for direct conversion of carboxylic acids to ketones utilizing zinc ate complexes.
abstract: Various carboxylic acids were directly transformed into the corresponding ketones by utilizing organozinc ate complexes, which provide high chemoselectivity without any overreaction to the undesired tertiary carbinol, owing to formation of a stable tetrahedral zincioketal intermediate. This method offers good overall atom/step/pot economy and operational simplicity.
authors: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
authors: Ryo
authors: R
authors: Murata
authors: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. k1hirano@mol.f.u-tokyo.ac.jp.|Advanced Elements Chemistry Research Team, RIKEN Center for Sustainable Resource Science, and Elements Chemistry Laboratory, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan. k1hirano@mol.f.u-tokyo.ac.jp.
authors: Keiichi
authors: K
authors: Hirano
authors: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. uchiyama@mol.f.u-tokyo.ac.jp.|Advanced Elements Chemistry Research Team, RIKEN Center for Sustainable Resource Science, and Elements Chemistry Laboratory, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan. uchiyama@mol.f.u-tokyo.ac.jp.
authors: Masanobu
authors: M
authors: Uchiyama
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D056831:Coordination Complexes; D007659:Ketones; D015032:Zinc
keywords: carboxylic acids; chemoselective; density functional calculations; ketones; organozincates