title: Fast preparation of a highly efficient organic monolith via photo-initiated thiol-ene click polymerization for capillary liquid chromatography.
abstract: A novel organic monolith was firstly prepared in a UV-transparent fused-silica capillary by a single-step approach via photo-initiated thiol-ene click polymerization reaction of 1,2,4-trivinylcyclohexane (TVCH) and pentaerythriol tetra(3-mercaptopropionate) (4SH) within 10min. The effects of both composition of prepolymerization solution and polymerization time on the morphology and permeability of monolithic column were investigated in detail. Then, the optimal condition was acquired to fabricate a homogeneous and permeable organic monolith. The chemical groups of the monolithic column were confirmed by Fourier transform infrared spectroscopy (FT-IR). The SEM graphs showed the organic monolith possessed a uniform porous structure, which promotes the highest column efficiency of ∼133,000 plates per meter for alkylbenzenes at the linear velocity of 0.65mm/s in reversed-phase liquid chromatography. Finally, the organic monolithic column was further applied for separation of basic compounds, pesticides and EPA610, indicating satisfactory separation ability.
authors: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; Graduate School of Chinese Academy of Sciences, Beijing 100049, China.
authors: Lianfang
authors: L
authors: Chen
authors: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address: junjieou@dicp.ac.cn.
authors: Junjie
authors: J
authors: Ou
authors: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; Graduate School of Chinese Academy of Sciences, Beijing 100049, China.
authors: Zhongshan
authors: Z
authors: Liu
authors: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; Graduate School of Chinese Academy of Sciences, Beijing 100049, China.
authors: Hui
authors: H
authors: Lin
authors: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors: Hongwei
authors: H
authors: Wang
authors: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors: Jing
authors: J
authors: Dong
authors: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address: hanfazou@dicp.ac.cn.
authors: Hanfa
authors: H
authors: Zou
mesh_terms: D015097:3-Mercaptopropionic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D056148:Chromatography, Reverse-Phase / Q000295:instrumentation* / Q000379:methods; D057930:Click Chemistry; D003510:Cyclohexanes / Q000737:chemistry*; D055668:Photochemical Processes; D058105:Polymerization; D012822:Silicon Dioxide; D017550:Spectroscopy, Fourier Transform Infrared; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D003510:Cyclohexanes; D013438:Sulfhydryl Compounds; C000600385:pentaerythriol tetra(3-mercaptopropionate); D012822:Silicon Dioxide; C000600384:1,2,4-trivinylcyclohexane; D015097:3-Mercaptopropionic Acid
keywords: 1,2,4-Trivinylcyclohexane; Capillary liquid chromatography; Organic monolith; Photo-initiated polymerization; Thiol-ene click reaction