title: Cutaneous manifestations in antiphospholipid syndrome.
abstract: Antiphospholipid syndrome (APS) is a hypercoagulable state that leads to thrombosis and recurrent pregnancy loss related to the presence of antiphospholipid antibodies (LAC, anticardiolipin, antiA2-glycoprotein). Among cutaneous manifestations, livedo reticularis is the most frequent form of APS. In the literature, there are rare cases associated with diffuse skin necrosis (widespread skin necrosis) and intravascular thrombosis in the small vessels of the dermis. We describe the case of a 44-year-old man with positive anticardiolipin antibodies and protein S deficiency that developed scattered, bullous skin lesions, haemorrhagic in appearance with signs of necrosis as first clinical manifestation of antiphospholipid syndrome.
authors: Division of Dermatology, Department of Medicine, Sapienza University, Polyclinic Umberto I Hospital, Rome, Italy.
authors: S
authors: S
authors: Caporuscio
authors: Division of Rheumatology, Department of Medicine, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
authors: M L
authors: ML
authors: Sorgi
authors: Department of Health Sciences; University of Catanzaro "Magna Graecia", Italy steven.nistico@gmail.com.
authors: S
authors: S
authors: Nisticò
authors: Division of Dermatology, Department of Medicine, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
authors: G
authors: G
authors: Pranteda
authors: Department of Health Sciences; University of Catanzaro "Magna Graecia", Italy.
authors: U
authors: U
authors: Bottoni
authors: Division of Dermatology, Department of Health Systems, TorVergata University, Rome, Italy.
authors: I
authors: I
authors: Carboni
authors: Department of Health Sciences; University of Catanzaro "Magna Graecia", Italy.
authors: E
authors: E
authors: Del Duca
authors: Division of Dermatology, Department of Medicine, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
authors: G
authors: G
authors: Pranteda
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000009:adverse effects* / Q000378:metabolism; D017152:Antibodies, Antiphospholipid / Q000009:adverse effects* / Q000378:metabolism; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000378:metabolism; D006801:Humans; D008297:Male; D009336:Necrosis / Q000209:etiology / Q000378:metabolism; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D012871:Skin Diseases / Q000209:etiology* / Q000378:metabolism; D013927:Thrombosis / Q000209:etiology / Q000378:metabolism
chemical_list: D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid
keywords: antiphosholipid syndrome; intravascular thrombosis; necrosis