title: γ-Aminobutyric Acid (GABA) Production and Angiotensin-I Converting Enzyme (ACE) Inhibitory Activity of Fermented Soybean Containing Sea Tangle by the Co-Culture of Lactobacillus brevis with Aspergillus oryzae.
abstract: To enhance the γ-aminobutyric acid (GABA) content, the optimized fermentation of soybean with added sea tangle extract was evaluated at 30°C and pH 5.0. The medium was first inoculated with Aspergillus oryzae strain FMB S46471 and fermented for 3 days, followed by the subsequent inoculation with Lactobacillus brevis GABA 100. After fermentation for 7 days, the fermented soybean showed approximately 1.9 g/kg GABA and exhibited higher ACE inhibitory activity than the traditional soybean product. Furthermore, several peptides in the fraction containing the highest ACE inhibitory activity were identified. The novel fermented soybean enriched with GABA and ACE inhibitory components has great pharmaceutical and functional food values.
authors: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Republic of Korea.
authors: Eun Kyeong
authors: EK
authors: Jang
authors: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Republic of Korea.
authors: Nam Yeun
authors: NY
authors: Kim
authors: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Republic of Korea.
authors: Hyung Jin
authors: HJ
authors: Ahn
authors: Department of Food and Nutrition, Research Institute of Human Ecology, Seoul National University, Seoul 151-742, Republic of Korea.|Research Institute, Bifido Co., Ltd., Hongchun 250-804, Republic of Korea.
authors: Geun Eog
authors: GE
authors: Ji
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000378:metabolism*; D001236:Aspergillus oryzae / Q000254:growth & development / Q000378:metabolism*; D018920:Coculture Techniques; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D044423:Kelp / Q000378:metabolism*; D052196:Levilactobacillus brevis / Q000254:growth & development / Q000378:metabolism*; D013025:Glycine max / Q000378:metabolism*; D013696:Temperature; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D005680:gamma-Aminobutyric Acid
keywords: Angiotensin-I Converting Enzyme Inhibition; Aspergillus oryzae; Lactobacillus brevis; Sea Tangle; Soybean; γ-Aminobutyric Acid