title: Integrity of white matter microstructure in alcoholics with and without Korsakoff's syndrome.
abstract: Alcohol dependence results in two different clinical forms: "uncomplicated" alcoholism (UA) and Korsakoff's syndrome (KS). Certain brain networks are especially affected in UA and KS: the frontocerebellar circuit (FCC) and the Papez circuit (PC). Our aims were (1) to describe the profile of white matter (WM) microstructure in FCC and PC in the two clinical forms, (2) to identify those UA patients at risk of developing KS using their WM microstructural integrity as a biomarker. Tract-based spatial statistics and nonparametric voxel-based permutation tests were used to compare diffusion tensor imaging (DTI) data in 7 KS, 20 UA, and 14 healthy controls. The two patient groups were also pooled together and compared to controls. k-means classifications were then performed on mean fractional anisotropy values of significant clusters across all subjects for two fiber tracts from the FCC (the middle cerebellar peduncle and superior cerebellar peduncle) and two tracts from the PC (fornix and cingulum). We found graded effects of WM microstructural abnormalities in the PC of UA and KS. UA patients classified at risk of developing KS using fiber tracts of the PC from DTI data also had the lowest scores of episodic memory. That finding suggests that WM microstructure could be used as a biomarker for early detection of UA patients at risk of developing KS.
authors: INSERM, Caen, France.|Université De Caen Basse-Normandie, Caen, France.|Ecole Pratique Des Hautes Etudes, Caen, France.|Centre Hospitalier Universitaire, Caen, France.
authors: Shailendra
authors: S
authors: Segobin
authors: INSERM, Caen, France.|Université De Caen Basse-Normandie, Caen, France.|Ecole Pratique Des Hautes Etudes, Caen, France.|Centre Hospitalier Universitaire, Caen, France.
authors: Ludivine
authors: L
authors: Ritz
authors: INSERM, Caen, France.|Université De Caen Basse-Normandie, Caen, France.|Ecole Pratique Des Hautes Etudes, Caen, France.|Centre Hospitalier Universitaire, Caen, France.
authors: Coralie
authors: C
authors: Lannuzel
authors: INSERM, Caen, France.|Université De Caen Basse-Normandie, Caen, France.|Ecole Pratique Des Hautes Etudes, Caen, France.|Centre Hospitalier Universitaire, Caen, France.|Centre Hospitalier Universitaire, Service D'addictologie, Caen, France.
authors: Céline
authors: C
authors: Boudehent
authors: INSERM, Caen, France.|Université De Caen Basse-Normandie, Caen, France.|Ecole Pratique Des Hautes Etudes, Caen, France.|Centre Hospitalier Universitaire, Caen, France.|Centre Hospitalier Universitaire, Service D'addictologie, Caen, France.
authors: François
authors: F
authors: Vabret
authors: INSERM, Caen, France.|Université De Caen Basse-Normandie, Caen, France.|Ecole Pratique Des Hautes Etudes, Caen, France.|Centre Hospitalier Universitaire, Caen, France.
authors: Francis
authors: F
authors: Eustache
authors: INSERM, Caen, France.|Université De Caen Basse-Normandie, Caen, France.|Ecole Pratique Des Hautes Etudes, Caen, France.|Centre Hospitalier Universitaire, Caen, France.
authors: Hélène
authors: H
authors: Beaunieux
authors: INSERM, Caen, France.|Université De Caen Basse-Normandie, Caen, France.|Ecole Pratique Des Hautes Etudes, Caen, France.|Centre Hospitalier Universitaire, Caen, France.
authors: Anne-Lise
authors: AL
authors: Pitel
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000473:pathology*; D015415:Biomarkers; D065850:Cerebral Peduncle / Q000473:pathology*; D016000:Cluster Analysis; D056324:Diffusion Tensor Imaging / Q000379:methods*; D042241:Early Diagnosis; D005260:Female; D020712:Fornix, Brain / Q000473:pathology*; D006179:Gyrus Cinguli / Q000473:pathology*; D006801:Humans; D020915:Korsakoff Syndrome / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D061212:Memory, Episodic; D008875:Middle Aged; D065837:Middle Cerebellar Peduncle / Q000473:pathology*; D066127:White Matter / Q000473:pathology*
chemical_list: D015415:Biomarkers
keywords: Korsakoff's syndrome; Papez's circuit; alcoholism; classification; frontocerebellar circuit; tract-based spatial statistics