title: Hikiamides A-C, Cyclic Pentadepsipeptides from Fusarium sp. TAMA 456.
abstract: Three new cyclic pentadepsipeptides, hikiamides A-C (1-3), were isolated from the culture extract of Fusarium sp. TAMA 456. The structures were determined by spectroscopic analysis using NMR and MS, and the absolute configurations were established by using Marfey's method and chiral HPLC analysis. Hikiamides induced the differentiation of murine ST-13 preadipocytes into mature adipocytes at 2 μM and adiponectin mRNA expression (5- to 13-fold higher than control). They also induced PPAR-γ-dependent gene expression at a concentration from 0.63 to 10 μM in a gene reporter assay.
authors: †Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
authors: Takao
authors: T
authors: Fukuda
authors: ‡Hyphagenesis Inc., 6-2-37 Tamagawa Gakuen, Machida, Tokyo 194-0041, Japan.
authors: Yuri
authors: Y
authors: Sudoh
authors: ‡Hyphagenesis Inc., 6-2-37 Tamagawa Gakuen, Machida, Tokyo 194-0041, Japan.
authors: Yuki
authors: Y
authors: Tsuchiya
authors: §Botanical Gardens, The University of Tokyo, 3-7-1 Hakusan, Bunkyo, Tokyo 112-0001, Japan.
authors: Toru
authors: T
authors: Okuda
authors: ⊥Department of Life Science, Faculty of Science, Okayama University of Science, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-0005, Japan.
authors: Nobuyasu
authors: N
authors: Matsuura
authors: ∥Department of Nutritional Biochemistry, School of Nutrition and Dietetics, Kanagawa University of Human Services, 1-10-1 Heisei-cho, Yokosuka, Kanagawa 238-8522, Japan.
authors: Atsuko
authors: A
authors: Motojima
authors: ∥Department of Nutritional Biochemistry, School of Nutrition and Dietetics, Kanagawa University of Human Services, 1-10-1 Heisei-cho, Yokosuka, Kanagawa 238-8522, Japan.
authors: Tsutomu
authors: T
authors: Oikawa
authors: †Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan.
authors: Yasuhiro
authors: Y
authors: Igarashi
mesh_terms: D017667:Adipocytes / Q000187:drug effects; D000818:Animals; D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification*; D005670:Fusarium / Q000737:chemistry*; D008156:Luciferases / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D047495:PPAR gamma / Q000378:metabolism; D016133:Polymerase Chain Reaction; D010456:Peptides, Cyclic
chemical_list: D047630:Depsipeptides; D008156:Luciferases; D047495:PPAR gamma; C000600761:hikiamide A; D010456:Peptides, Cyclic; C000600762:hikiamide B; C000600763:hikiamide C