title: Pd(II)-Catalyzed Pyridine N-Oxides Directed Arylation of Unactivated Csp(3)-H Bonds.
abstract: A novel Pd(II)-catalyzed pyridine N-oxide directed remote arylation of unactivated Csp(3)-H bonds in aliphatic amides with aryl iodides has been developed. This protocol allows installing various aryl groups at the β- or γ-Csp(3) atom of alkyl carboxylic acid amides. The key palladabicyclic intermediate of this transformation has been identified by HR-MS and (1)H NMR method.
authors: †Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors: Jianzhong
authors: J
authors: Liu
authors: ‡School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
authors: Ying
authors: Y
authors: Xie
authors: ‡School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
authors: Wei
authors: W
authors: Zeng
authors: ‡School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
authors: Dongen
authors: D
authors: Lin
authors: ‡School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China.
authors: Yuanfu
authors: Y
authors: Deng
authors: †Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors: Xiaoxia
authors: X
authors: Lu
mesh_terms: D000577:Amides / Q000737:chemistry; D002384:Catalysis; D006847:Hydrocarbons, Iodinated / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000577:Amides; D006847:Hydrocarbons, Iodinated; D009942:Organometallic Compounds; D011725:Pyridines; D010165:Palladium; C013229:pyridine N-oxide