title: The effect of Terminalia chebula extract vs. silver sulfadiazine on burn wounds in rats.
abstract: BACKGROUND
  The aim of this study was to evaluate the efficacy of ethanol extract of Terminalia chebula in the treatment of hot water-induced burn wounds and to compare the results with silver sulfadiazine (SSD) in rats.
  
  
  METHODS
  Five groups of ten rats were burned with hot water. Animals were administrated with topical cream at control, normal saline, 5%, 10% T. chebula extracts and standard SSD creams. Several parameters were assessed, including wound area, visual inspection of wound, bacteriology assessment, percentage of wound contraction and histopathological examination.
  
  
  RESULTS
  The average area of wound on 10th day was 11.2 ± 3.3, 11 ± 3.2, 8.5 ± 2.3, 9.5 ± 4.2 and 5.1 ± 2.2 cm(2) for SSD1%, base cream, normal saline, herbal extract 5% and 10%, respectively. T. chebula 10% cream exhibited lower wound size than SSD1% and control groups at 10th day post burn injury. On day 15, the percentage of wound contraction in T. chebula was 5% and 10% more than 18% and 53% in comparison to SSD1% group, respectively. Histopathological results exhibited well-formed horizontally oriented collagen fibers for appropriate tension. Strength of scar on burned tissue was better in T. chebula 5% and 10% as compared with control and SSD groups.
  
  
  CONCLUSIONS
  The results of this study showed that T. chebula extract was capable of accelerating wound healing in rats by wound contraction, and had beneficial effects more than SSD 1% cream in the management of burn injury.
authors: Ebrahim
authors: E
authors: Nasiri
authors: Seyed Jalal
authors: SJ
authors: Hosseinimehr
authors: Mohammad
authors: M
authors: Azadbakht
authors: Jafar
authors: J
authors: Akbari
authors: Reza
authors: R
authors: Enayati-Fard
authors: Sohail
authors: S
authors: Azizi
mesh_terms: D000818:Animals; D002056:Burns / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D017208:Rats, Wistar; D012837:Silver Sulfadiazine / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D029766:Terminalia; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D012837:Silver Sulfadiazine