title: Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology.
abstract: Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the PPARs, which are transcription factors of the steroid receptor superfamily. PPARγ acts as an important molecule for regulating energy homeostasis, modulates the hypothalamic-pituitary-gonadal (HPG) axis, and is reciprocally regulated by HPG. In the human, PPARγ protein is highly expressed in ejaculated spermatozoa, implying a possible role of PPARγ signaling in regulating sperm energy dissipation. PPARγ protein is also expressed in Sertoli cells and germ cells (spermatocytes). Its activation can be induced during capacitation and the acrosome reaction. This mini-review will focus on how PPARγ signaling may affect fertility and sperm quality and the potential reversibility of these adverse effects.
authors: Li-Li
authors: LL
authors: Liu
authors: Hua
authors: H
authors: Xian
authors: Jing-Chen
authors: JC
authors: Cao
authors: Chong
authors: C
authors: Zhang
authors: Yong-Hui
authors: YH
authors: Zhang
authors: Miao-Miao
authors: MM
authors: Chen
authors: Yi
authors: Y
authors: Qian
authors: Laboratory of Nuclear Receptors and Cancer Research, Basic Medical Research Center, Nantong University School of Medicine, Nantong, Jiangsu, China; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA, .
authors: Ming
authors: M
authors: Jiang
mesh_terms: D020101:Acrosome Reaction / Q000502:physiology*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D005298:Fertility / Q000502:physiology*; D005306:Fertilization / Q000502:physiology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007248:Infertility, Male / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008297:Male; D047495:PPAR gamma / Q000378:metabolism* / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D055101:Semen Analysis; D012708:Sertoli Cells / Q000378:metabolism*; D015398:Signal Transduction; D013075:Sperm Capacitation / Q000502:physiology*; D013090:Spermatocytes / Q000378:metabolism*; D013091:Spermatogenesis / Q000502:physiology; D013094:Spermatozoa / Q000378:metabolism* / Q000502:physiology; D013737:Testis / Q000378:metabolism
chemical_list: D020738:Leptin; D047495:PPAR gamma; D019869:Phosphatidylinositol 3-Kinases