title: [The extract of blackend swallowwort root up-regulates the expressions of angiogenesis related proteins and promotes liver angiogenesis of mice with partial hepatectomy].
abstract: OBJECTIVE
  To observe the effects of the extract of blackend swallowwort root (EBSR) on neovascularization after partial hepatectomy and explore the corresponding molecules and mechanism of the regulation.
  
  
  METHODS
  Twenty mice were randomly divided into control group and EBSR group. Mice in the two groups were subjected to a one-time resection of part of the left lateral lobe of the liver. The mice in the experimental group were treated with EBSR by intragastric administration at a dose of 50 g/kg, twice per day after operation. During the eight days after the operation, one mouse in each group was sacrificed every day and the left lateral liver lobe was harvested. Immunohistochemistry was used to detect the expressions of vascular endothelial growth factor-C (VEGF-C), VEGF-A, lymphatic vessel endothelial HA receptor-1 (LYVE-1) and CD34.
  
  
  RESULTS
  Compared with the control group, the significantly increased expression of CD34 in mice of the EBSR group was observed, as well as expanded distribution. Also, a decrease in the early phase but a significant increase in the latter was seen in the expressions of VEGF-C, VEGF-A and LYVE-1.
  
  
  CONCLUSIONS
  EBSR can up-regulate the expressions of VEGF-C, VEGF-A and LYVE-1 so as to promote liver angiogenesis of mice with partial hepatectomy.
authors: Department of Anatomy and Biology, Shandong college of Traditional Chinese Medicine, Yantai 264199, China.
authors: Fanwei
authors: F
authors: Meng
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000235:genetics* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D008107:Liver Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D026901:Membrane Transport Proteins; D051379:Mice; D009389:Neovascularization, Pathologic; D018517:Plant Roots / Q000737:chemistry; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics* / Q000378:metabolism; D042582:Vascular Endothelial Growth Factor C / Q000235:genetics* / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D004365:Drugs, Chinese Herbal; D006023:Glycoproteins; D026901:Membrane Transport Proteins; D042461:Vascular Endothelial Growth Factor A; D042582:Vascular Endothelial Growth Factor C; C492273:LYVE1 protein, mouse