title: [Efficacies of continuous high volume hemofiltration in severe sepsis patients with multiple organ dysfunction syndrome].
abstract: OBJECTIVE
  To explorer the efficacies of continuous high volume hemofiltration (CHVHF) in severe sepsis patients with multiple organ dysfunction syndrome (MODS).
  
  
  METHODS
  A total of 80 cases of severe sepsis patients with MODS treated at our center from 2011 January to 2013 October were selected and assigned to receive CHVHF (n = 42) and continuous volume hemofiltration (CVHF, n = 38). The changes of vital signs, acute physiology & chronic health evaluationII (APACHEII) scores, MODS evaluation scores, hemodynamics, liver & kidney function parameters, arterial blood lactate and procalcitonin (PCT) were observed before and after treatment.
  
  
  RESULTS
  After treatment, their temperatures and heart rates improved and the scores of APACHEIIand MODS were significantly lower (P < 0.05). Hemodynamics significantly improved at 48 and 72 h post-treatment. The values of mean arterial pressure (MAP), cardiac index (CI), stroke volume index (SVI) and systemic vascular resistance index (SVRI) became stabilized as compared with pre-treatment. There were significant differences (P < 0.05). The parameters of liver and kidney function gradually improved after CHVHF. And arterial blood lactate and PCT returned to normal at 24, 48 and 72 h post-treatment (P < 0.05).
  
  
  CONCLUSIONS
  CHVHF may stabilize vital signs and improve hemodynamics, organ function and tissue perfusion in septic patients with MODS.
authors: Intensive Care Unit, Second People's Hospital of Linhai, Zhejiang 317016, China.
authors: Chongjun
authors: C
authors: Du
authors: Department of Emergency Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hanzhou 310003, China. Email: dcjhhl@163.com.
authors: Hongliu
authors: H
authors: Cai
authors: Shaokun
authors: S
authors: Shao
authors: Qibei
authors: Q
authors: Yan
mesh_terms: D006339:Heart Rate; D006439:Hemodynamics; D006440:Hemofiltration; D006801:Humans; D019344:Lactic Acid; D009102:Multiple Organ Failure; D006435:Renal Dialysis; D018805:Sepsis; D013318:Stroke Volume
chemical_list: D019344:Lactic Acid