title: pH-triggered self-assembly of biocompatible histamine-functionalized triblock copolymers.
abstract: Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hudrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.
authors: Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA.
authors: Pontus
authors: P
authors: Lundberg
authors: Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA.
authors: Nathaniel A
authors: NA
authors: Lynd
authors: Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institutet, Retzius väg 8, Stockholm SE-171 77, Sweden.
authors: Yuning
authors: Y
authors: Zhang
authors: Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institutet, Retzius väg 8, Stockholm SE-171 77, Sweden.
authors: Xianghui
authors: X
authors: Zeng
authors: Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA.
authors: Daniel V
authors: DV
authors: Krogstad
authors: Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA.
authors: Tim
authors: T
authors: Paffen
authors: Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, School of Chemical Science and Engineering, Teknikringen 56-58, Stockholm SE-100 44, Sweden.
authors: Michael
authors: M
authors: Malkoch
authors: Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institutet, Retzius väg 8, Stockholm SE-171 77, Sweden.
authors: Andreas M
authors: AM
authors: Nyström
authors: Materials Research Laboratory, University of California, Santa Barbara, CA 93106, USA ; Department of Chemistry and Biochemistry and Materials Department, University of California, Santa Barbara, CA 93106, USA.
authors: Craig J
authors: CJ
authors: Hawker