title: Long noncoding RNAs POLR2E rs3787016 C/T and HULC rs7763881 A/C polymorphisms are associated with decreased risk of esophageal cancer.
abstract: Worldwide, rates of esophageal cancer have been keeping highly in recent decades. Genetic variants in multiple cellular pathways might play an important role in altering risk of esophageal carcinoma. In this study, long noncoding RNAs (lncRNAs) functional single nucleotide polymorphisms (SNPs) were investigated in Chinese Han populations. We have genotyped the ANRIL rs2151280 T/C, POLR2E rs3787016 C/T, and HULC rs7763881 A/C SNPs in 380 esophageal squamous cell carcinoma (ESCC) cases and 380 cancer-free controls. POLR2E rs3787016 C/T was associated with a significantly decreased risk for ESCC (CT vs. CC: OR 0.62, 95 % CI 0.44-0.87, P = 0.005; adjusted OR 0.62, 95 % CI 0.44-0.87, P = 0.005). The other SNP, HULC rs7763881, also showed a suggestive association (AC vs. AA: OR 0.70, 95 % CI 0.50-0.98, P = 0.037; adjusted OR 0.69, 95 % CI 0.49-0.97, P = 0.031). ANRIL rs2151280 T/C SNP was not associated with risk of ESCC. In the future, larger studies with other ethnic populations, tissue-specific biological characterization, and detailed individual information should be undertaken to validate current findings.
authors: Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 350001, Fujian Province, China, Mingqiang_Kang@126.com.
authors: Mingqiang
authors: M
authors: Kang
authors: Yonghua
authors: Y
authors: Sang
authors: Haiyong
authors: H
authors: Gu
authors: Liang
authors: L
authors: Zheng
authors: Liming
authors: L
authors: Wang
authors: Chao
authors: C
authors: Liu
authors: Yijun
authors: Y
authors: Shi
authors: Aizhong
authors: A
authors: Shao
authors: Guowen
authors: G
authors: Ding
authors: Suocheng
authors: S
authors: Chen
authors: Weifeng
authors: W
authors: Tang
authors: Jun
authors: J
authors: Yin
mesh_terms: D000368:Aged; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: C561518:CDKN2B antisense RNA, human; C574685:HULC long non-coding RNA, human; D062085:RNA, Long Noncoding; D012321:DNA-Directed RNA Polymerases; C517511:POLR2E protein, human