title: Decreased concentration of Klotho in the cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis.
abstract: Recent investigations support that an anti-aging protein, namely Klotho, protects neurons against the oxidative stress and demyelination. We evaluated the protein concentration of Klotho and total anti-oxidant capacity (TAC) in the cerebrospinal fluid (CSF) of patients with relapsing-remitting multiple sclerosis (RRMS). Klotho concentration and TAC were significantly lower in patients as compared to controls. Klotho values showed a significant negative correlation with expanded disability status scale (EDSS). Moreover, a significantly positive correlation between TAC levels and Klotho concentrations was detected. Klotho may play an important role in the pathogenesis of MS, at least in part, through the regulation of redox system.
authors: Department of Clinical Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Mohammad Sajad
authors: MS
authors: Emami Aleagha
authors: Department of Neurology, Iranian Centre of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Bahaadin
authors: B
authors: Siroos
authors: Department of Neurology, Iranian Centre of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mona
authors: M
authors: Ahmadi
authors: Department of Clinical Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Mohammad
authors: M
authors: Balood
authors: Department of Clinical Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Alireza
authors: A
authors: Palangi
authors: Department of Neurology, Iranian Centre of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Afsaneh Nazari
authors: AN
authors: Haghighi
authors: Department of Neurology, Iranian Centre of Neurological Research, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: harirchm@tums.ac.ir.
authors: Mohammad Hossein
authors: MH
authors: Harirchian
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D005260:Female; D005966:Glucuronidase / Q000134:cerebrospinal fluid*; D006801:Humans; D000090265:Klotho Proteins; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: FRAP assay; Klotho; Multiple sclerosis; Redox system