title: Generation and functions of second messengers microdomains.
abstract: A compelling example of the mechanisms by which the cells can organize and decipher complex and different functional activities is the convergence of a multitude of stimuli into signalling cascades, involving only few intracellular second messengers. The possibility of restricting these signalling events in distinct microdomains allows a fine and selective tuning of very different tasks. In this review, we will discuss the mechanisms that control the formation and the spatial distribution of Ca(2+) and cAMP microdomains, providing some examples of their functional consequences.
authors: Department of Biomedical Sciences, University of Padova, Italy.
authors: Riccardo
authors: R
authors: Filadi
authors: Department of Biomedical Sciences, University of Padova, Italy; CNR Institute of Neuroscience, Padova Section, Padova, Italy; Venetian Institute of Molecular Medicine (VIMM), Padova, Italy. Electronic address: tullio.pozzan@unipd.it.
authors: Tullio
authors: T
authors: Pozzan
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D002118:Calcium
keywords: Ca(2+); Channels; Mitochondria; cAMP