title: Morphogens Reveal the Appearance and Functions of lncRNAs.
abstract: During the first meiotic division, the entire genetic information from DNA is transcribed into mRNPs and stored in the ovoplasm in the form of mRNP particles. The 39 human nuclear HOX proteins bind to thousands of mRNAs transcribed repeatedly by lampbrush chromosomes. HOX proteins suppress processing and translation. The RNP particles containing lncRNAs+HOX proteins are the morphogens ("transcription factors," more precisely differentiation factors), which unlock new genes and differentiate the cells of the developing embryo. All ovoplasmic mRNAs bound with HOX proteins do not translate and are noncoding. Their destination (purpose) is transportation of HOX proteins to the complementary DNAs and cell differentiation.
authors: Institute of Experimental Morphology and Anthropology, Bulgarian Academy of Sciences , Sofia, Bulgaria .
authors: Marlene
authors: M
authors: Anastassova-Kristeva
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D018398:Homeodomain Proteins; D062085:RNA, Long Noncoding; D014157:Transcription Factors