title: Effect of lung transplantation on heart rate response to exercise.
abstract: OBJECTIVE
  To evaluate if patients have a change in percent of predicted heart rate reserve used at peak exercise (%HRR) after lung transplantation, even at matching workloads.
  
  
  BACKGROUND
  Lung disease of obstructive, restrictive, and mixed types may be associated with an autonomic imbalance. Lung transplantation may improve the effects of pulmonary disease on cardiac function. However, the effect of lung transplantation on heart rate responses during exercise has not been investigated in detail.
  
  
  METHODS
  Retrospective review of patients who underwent lung transplantation. Pre and post transplant cardiopulmonary exercise tests were reviewed.
  
  
  RESULTS
  The %HRR significantly improved by a median of 37% (p < 0.001) following lung transplantation. When matching workloads were analyzed, the %HRR also decreased from a median of 36% to 24% (p < 0.001).
  
  
  CONCLUSIONS
  Corresponding to an increase in peak exercise capacity, percentage of heart rate reserve used improves significantly after lung transplantation, even at matching workloads, indicating a likely improvement in autonomic modulation.
authors: Department of Rehabilitation and Regenerative Medicine, Columbia University Medical Center, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. Electronic address: hfa2104@columbia.edu.
authors: Hilary F
authors: HF
authors: Armstrong
authors: Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
authors: Jose
authors: J
authors: Gonzalez-Costello
authors: Department of Rehabilitation Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Thailand.
authors: Wilawan
authors: W
authors: Thirapatarapong
authors: Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
authors: Ulrich P
authors: UP
authors: Jorde
authors: Department of Rehabilitation Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
authors: Matthew N
authors: MN
authors: Bartels
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
keywords: CPET; Chronotropic incompetence; Exercise; Heart rate; Lung transplantation