title: Is surveillance colonoscopy necessary for patients with sporadic gastric hyperplastic polyps?
abstract: BACKGROUND
  Gastric polyps, such as adenomas and hyperplastic polyps, can be found in various colonic polyposis syndromes. Unlike in sporadic gastric adenomas, in which the increased risk of colorectal neoplasia has been well characterized, information in sporadic gastric hyperplastic polyps was limited.
  
  
  OBJECTIVE
  To evaluate the association of sporadic gastric hyperplastic polyps with synchronous colorectal neoplasia in a large cohort.
  
  
  METHODS
  Patients with sporadic gastric hyperplastic polyps who underwent colonoscopy simultaneously or within six months were consecutively enrolled. Each patient was compared with two randomly selected age and sex matched controls without gastric polyps who also underwent colonoscopy in the same period. Data of patients' demographics and characteristics of the gastrointestinal polyps were documented.
  
  
  RESULTS
  A total of 261 cases in 118,576 patients who underwent esophagogastroduodenoscopy were diagnosed as sporadic gastric hyperplastic polyps, and 192 of 261 (73.6%) patients underwent colonoscopy. Colorectal neoplasias were identified in 46 (24.0%) of 192 cases and in 40 (10.4%) of 384 controls (P＜0.001). The mean size and distribution of colorectal neoplasias were not significantly different between the two groups. There was a significantly higher rate of colorectal adenoma (odds ratio [OR] 3.2, 95% confidence interval [CI] 1.9-5.3) in the gastric hyperplastic polyps group than in the control group, while the prevalence of colorectal cancer was similar in the two groups. Logistic regression analysis also suggested that the presence of gastric hyperplastic polyps (OR 2.5, 95% CI 1.5-4.0) was an independent risk factor for colorectal neoplasias.
  
  
  CONCLUSIONS
  The risk of colorectal adenoma increases in patients with sporadic gastric hyperplastic polyps, and surveillance colonoscopy for these patients should be considered.
authors: Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
authors: Hailong
authors: H
authors: Cao
authors: Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
authors: Nana
authors: N
authors: He
authors: Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
authors: Shuli
authors: S
authors: Song
authors: Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
authors: Mengque
authors: M
authors: Xu
authors: Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
authors: Meiyu
authors: M
authors: Piao
authors: Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
authors: Fang
authors: F
authors: Yan
authors: Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
authors: Bangmao
authors: B
authors: Wang
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D018256:Adenomatous Polyps / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003111:Colonic Polyps / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology