title: Salivary and serum insulin-like growth factor (IGF-1) assays in anorexic patients.
abstract: The purpose of this study was to measure the salivary and serum free IGF-1 concentration of patients with anorexia nervosa (AN) in comparison to an average population.
  
  
  
  A controlled clinical trial was designed for an age- and gender-matched group of 121 AN patients and 77 healthy individuals. A clinical examination was made and blood and salivary samples were taken during the acute stage of AN (BMI < 15 kg/m2) in the first week of hospitalization. An enzyme immunoassay (ELISA) suitable for measuring free IGF-1 was used.
  
  
  
  Anorexic patients had significant reductions in salivary unstimulated flow rate (UFR), pH and free IGF-1 levels in their saliva and serum. Significant correlations between serum IGF-1 and BMI; salivary IGF-1 and UFR and pH were detected.
  
  
  
  Salivary and serum IGF-1 analyses appear to be a reliable biochemical indicator of malnutrition in AN patients. Measurement of salivary IGF-1 levels would allow new perspectives in monitoring AN in its early stages.
authors: a Department of Biomaterials and Experimental Dentistry , Poznan University of Medical Sciences , Poznan , Poland.
authors: Elzbieta
authors: E
authors: Paszynska
authors: b Psychiatric Genetics Unit, Department of Psychiatry , Poznan University of Medical Sciences , Poznan , Poland.
authors: Monika
authors: M
authors: Dmitrzak-Weglarz
authors: c Department of Child and Adolescent Psychiatry , Poznan University of Medical Sciences , Poznan , Poland.
authors: Agnieszka
authors: A
authors: Slopien
authors: c Department of Child and Adolescent Psychiatry , Poznan University of Medical Sciences , Poznan , Poland.
authors: Marta
authors: M
authors: Tyszkiewicz-Nwafor
authors: c Department of Child and Adolescent Psychiatry , Poznan University of Medical Sciences , Poznan , Poland.
authors: Andrzej
authors: A
authors: Rajewski
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D011044:Poland; D012463:Saliva / Q000737:chemistry*
chemical_list: D007334:Insulin-Like Growth Factor I
keywords: IGF-1; anorexia nervosa; eating disorders; saliva; serum