title: Copper-catalyzed tandem phosphination-decarboxylation-oxidation of alkynyl acids with H-phosphine oxides: a facile synthesis of β-ketophosphine oxides.
abstract: The general method for the tandem phosphination-decarboxylation-oxidation of alkynyl acids under aerobic conditions has been developed. In the presence of CuSO4·5H2O and TBHP, the reactions provide a novel access to β-ketophosphine oxides in good to excellent yields. This transformation allows the direct formation of a P-C bond and the construction of a keto group in one reaction.
authors: Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China. t12g21@xmu.edu.cn.
authors: Pengbo
authors: P
authors: Zhang
authors: Liangliang
authors: L
authors: Zhang
authors: Yuzhen
authors: Y
authors: Gao
authors: Jian
authors: J
authors: Xu
authors: Hua
authors: H
authors: Fang
authors: Guo
authors: G
authors: Tang
authors: Yufen
authors: Y
authors: Zhao
mesh_terms: D000143:Acids / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry*; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000143:Acids; D000480:Alkynes; D009942:Organometallic Compounds; D010087:Oxides; D010720:Phosphines; D003300:Copper; C044646:phosphine