title: Regulation of systemic energy homeostasis by serotonin in adipose tissues.
abstract: Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show 5-HT regulates white and brown adipose tissue function. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Mice with inducible Tph1 KO in adipose tissues exhibit a similar phenotype as mice in which 5-HT synthesis is inhibited pharmacologically, suggesting 5-HT has localized effects on adipose tissues. In addition, Htr3a KO mice exhibit increased energy expenditure and reduced weight gain when fed a high-fat diet. Treatment with an Htr2a antagonist reduces lipid accumulation in 3T3-L1 adipocytes. These data suggest important roles for adipocyte-derived 5-HT in controlling energy homeostasis.
authors: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors: Chang-Myung
authors: CM
authors: Oh
authors: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.|Department of Biochemistry, Yonsei University Wonju College of Medicine, Wonju 220-701, Korea.
authors: Jun
authors: J
authors: Namkung
authors: Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-721, Korea.
authors: Younghoon
authors: Y
authors: Go
authors: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors: Ko Eun
authors: KE
authors: Shong
authors: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors: Kyuho
authors: K
authors: Kim
authors: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors: Hyeongseok
authors: H
authors: Kim
authors: Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-721, Korea.|BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-842, Korea.
authors: Bo-Yoon
authors: BY
authors: Park
authors: Department of Nuclear Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-721, Korea.
authors: Ho Won
authors: HW
authors: Lee
authors: Department of Nuclear Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-721, Korea.|Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 702-210, Korea.
authors: Yong Hyun
authors: YH
authors: Jeon
authors: Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul 463-707, Korea.
authors: Junghan
authors: J
authors: Song
authors: Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon 301-721, Korea.
authors: Minho
authors: M
authors: Shong
authors: Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
authors: Vijay K
authors: VK
authors: Yadav
authors: Department of Genetics and Development, Columbia University Medical Center, New York, New York 10032, USA.
authors: Gerard
authors: G
authors: Karsenty
authors: Diabetes Center, Hormone Research Institute and Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA.
authors: Shingo
authors: S
authors: Kajimura
authors: Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-721, Korea.|BK21 Plus KNU Biomedical Convergence Program, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-842, Korea.
authors: In-Kyu
authors: IK
authors: Lee
authors: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.|Department of Biochemistry, College of Medicine, Catholic Kwandong University, Gangneung 210-701, Korea.
authors: Sangkyu
authors: S
authors: Park
authors: BioMedical Research Center (E7) 8104, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors: Hail
authors: H
authors: Kim
mesh_terms: D041721:3T3-L1 Cells; D052437:Adipocytes, Brown / Q000378:metabolism / Q000473:pathology; D052438:Adipocytes, White / Q000378:metabolism / Q000473:pathology; D050156:Adipogenesis / Q000235:genetics*; D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000473:pathology; D052436:Adipose Tissue, White / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D059305:Diet, High-Fat; D004734:Energy Metabolism / Q000235:genetics; D004822:Epididymis / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D006706:Homeostasis / Q000235:genetics*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009765:Obesity / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics / Q000378:metabolism; D044406:Receptors, Serotonin, 5-HT3 / Q000172:deficiency / Q000235:genetics; D012701:Serotonin / Q000378:metabolism*; D022722:Thermogenesis / Q000235:genetics; D014365:Tryptophan Hydroxylase / Q000172:deficiency / Q000235:genetics
chemical_list: C511230:Htr3a protein, mouse; D044402:Receptor, Serotonin, 5-HT2A; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin; C487801:Tph1 protein, mouse; D014365:Tryptophan Hydroxylase