title: Effects of titanium dioxide nanoparticles coupled with diode laser on optical properties of in vitro normal and cancerous human lung tissues studied with optical coherence tomography and diffuse reflectance spectra.
abstract: The objective is to investigate the effects of two different sized (60 and 100 nm) titanium dioxide (TiO2) nanoparticles (NPs) penetration and accumulation in in vitro human normal lung (NL) tissue, lung squamous cell carcinoma (LSCC) tissue, and 650-nm diode laser-pretreated tissue on their optical properties studied with optical coherence tomography monitoring and diffuse reflectance (DR) spectra measurement. As with TiO2 NPs penetrating into the tissues, the intensities of DR of the samples increase, and then the enhancements of DR and the attenuation coefficients of the tissues were quantitatively calculated. The results suggest that 650-nm diode laser pretreatment increased the amounts of TiO2 NPs penetration and accumulation in NL and LSCC tissues, and the tissue optical properties were significantly influenced by accumulation of TiO2 NPs.
authors: South China Normal University, College of Biophotonics, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, Guangzhou, Guangdong Province 510631, China.
authors: Lianpeng
authors: L
authors: Zhou
authors: Sun Yat-Sen University, the First Affiliated Hospital, Department of Surgery, 58 Zhongshan 2 Road, Guangzhou, Guangdong Province 510080, China.
authors: Guoyong
authors: G
authors: Wu
authors: South China Normal University, College of Biophotonics, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, Guangzhou, Guangdong Province 510631, China.
authors: Huajiang
authors: H
authors: Wei
authors: South China Normal University, College of Biophotonics, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, Guangzhou, Guangdong Province 510631, China.
authors: Zhouyi
authors: Z
authors: Guo
authors: Fujian Normal University, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, 1 Keji Road, Fuzhou, Fujian 350007, China.
authors: Hongqin
authors: H
authors: Yang
authors: Tsinghua University, Graduate School at Shenzhen, 2279 Lishui Road, Shenzhen, Guangdong 518055, China.
authors: Yonghong
authors: Y
authors: He
authors: Fujian Normal University, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education of China, 1 Keji Road, Fuzhou, Fujian 350007, China.
authors: Shusen
authors: S
authors: Xie
authors: South China Normal University, College of Biophotonics, MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, 55 Zhongshan Road, Guangzhou, Guangdong Province 510631, China.
authors: Ying
authors: Y
authors: Liu
authors: Southwest Institute of Technical Physics, 7 People's South Road, Chengdu, Sichuan 610041, China.
authors: Qingan
authors: Q
authors: Meng
mesh_terms: D006801:Humans; D054023:Lasers, Semiconductor; D008168:Lung / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology*; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D057054:Molecular Imaging / Q000379:methods; D010316:Particle Size; D012031:Refractometry; D013057:Spectrum Analysis / Q000379:methods; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology*; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: C009495:titanium dioxide; D014025:Titanium