title: Genetic polymorphisms of the multidrug resistance 1 gene MDR1 and the risk of hepatocellular carcinoma.
abstract: A possible association between multiple drug resistance 1 gene (MDR1) polymorphisms and the risk of developing hepatocellular carcinoma (HCC) is currently under debate, and evidence from various epidemiological studies has yielded controversial results. To derive a more precise estimation of the association between MDR1 polymorphisms and HCC risk, the present meta-analysis was performed. A total of 8 studies containing 11 cohorts with 4407 cases and 4436 controls were included by systematic literature search of EMBASE, PubMed, Web of Science, and CNKI. All polymorphisms were classified as mutant/wild-type alleles. In particular, the variation type, functional impact, and protein domain location of the polymorphisms were assessed and used as stratified indicators. The pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated to evaluate the association. Overall, our results suggested that the mutant alleles of the MDR1 gene were associated with a significantly increased risk for HCC under all genetic models (allelic model: OR = 1.28, 95 % CI = 1.20-1.36, P < 0.001; dominant model: OR = 1.27, 95 % CI = 1.16-1.38, P < 0.001; recessive model: OR = 1.59, 95 % CI = 1.36-1.85, P < 0.001). Furthermore, increased risks for HCC were also revealed in stratified analyses by ethnicity, sample size, and quality scores of cohorts as well as variation type, functional impact, and protein domain location of polymorphisms. In conclusion, the present meta-analysis suggested that the presence of MDR1 mutant alleles might be a risk factor for HCC.
authors: Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.|Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
authors: Zhi-Chao
authors: ZC
authors: Wang
authors: Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.|Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
authors: Long-Zi
authors: LZ
authors: Liu
authors: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
authors: Xin-Yang
authors: XY
authors: Liu
authors: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, People's Republic of China.
authors: Jin-Jing
authors: JJ
authors: Hu
authors: Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, People's Republic of China.
authors: Yong-Na
authors: YN
authors: Wu
authors: Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.|Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
authors: Jie-Yi
authors: JY
authors: Shi
authors: Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.|Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
authors: Liu-Xiao
authors: LX
authors: Yang
authors: Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.|Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
authors: Meng
authors: M
authors: Duan
authors: Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.|Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.
authors: Xiao-Ying
authors: XY
authors: Wang
authors: Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.|Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.|Institute of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
authors: Jian
authors: J
authors: Zhou
authors: Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China.|Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China.|Institute of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China.
authors: Jia
authors: J
authors: Fan
authors: Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical College, Fudan University, 180 Feng Lin Road, Shanghai, 200032, People's Republic of China. gao.qiang@zs-hospital.sh.cn.|Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, People's Republic of China. gao.qiang@zs-hospital.sh.cn.
authors: Qiang
authors: Q
authors: Gao
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D018432:Drug Resistance, Multiple / Q000235:genetics*; D005006:Ethnicity; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B
keywords: Gene polymorphism; Hepatocellular carcinoma; Meta-analysis; Multiple drug resistance 1 gene