title: Membranous nephropathy with monoclonal IgG4 deposits and associated IgG4-related lung disease.
abstract: A 62-year-old woman was admitted for nephrotic syndrome and lung tumor. A renal biopsy showed membranous features of the glomeruli. Immunofluorescence studies revealed granular IgG4-κ deposits along with the glomerular basement membrane. Electron microscopy revealed granular electron-dense deposits. Further study denied multiple myeloma. Light microscopy of the resected lung tumor revealed IgG4-related lung disease with no malignancy. Steroid therapy induced a remission of the nephrotic syndrome, with no recurrence of the lung tumor. We consider that this is the first case of a proliferative glomerulonephritis with monoclonal IgG deposits of IgG4 subclass, and a rare concurrence with IgG4-related disease.
authors: Department of General Internal Medicine and Clinical Laboratory Medicine , Akita University Graduate School of Medicine , Akita , Japan.
authors: Ayumi
authors: A
authors: Omokawa
authors: Department of Hematology, Nephrology and Rheumatology , Akita University Graduate School of Medicine , Akita , Japan.
authors: Atsushi
authors: A
authors: Komatsuda
authors: Department of General Internal Medicine and Clinical Laboratory Medicine , Akita University Graduate School of Medicine , Akita , Japan.
authors: Makoto
authors: M
authors: Hirokawa
authors: Department of Hematology, Nephrology and Rheumatology , Akita University Graduate School of Medicine , Akita , Japan ; Department of Life Science , Akita University Graduate School of Engineering and Resource Science , Akita , Japan.
authors: Hideki
authors: H
authors: Wakui
keywords: IgG4-related disease; nephrotic syndrome; proliferative glomerulonephritis with monoclonal IgG deposits