title: Uncontrolled Donation After Circulatory Determination of Death Donors (uDCDDs) as a Source of Lungs for Transplant.
abstract: In April 2014, the American Journal of Transplantation published a report on the first lung transplant in the United States recovered from an uncontrolled donation after circulatory determination of death donor (uDCDD), assessed by ex vivo lung perfusion (EVLP). The article identified logistical and ethical issues related to introduction of lung transplant from uDCDDs. In an open clinical trial, we have Food and Drug Administration and Institutional Review Board approval to transplant lungs recovered from uDCDDs judged suitable after EVLP. Through this project and other experiences with lung recovery from uDCDDs, we have identified solutions to many logistical challenges and have addressed ethical issues surrounding lung transplant from uDCDDs that were mentioned in this case report. Here, we discuss those challenges, including issues related to recovery of other solid organs from uDCDDs. Despite logistical challenges, uDCDDs could solve the critical shortage of lungs for transplant. Furthermore, by avoiding the deleterious impact of brain death and days of positive pressure ventilation, and by using opportunities to treat lungs in the decedent or during EVLP, lungs recovered from uDCDDs may ultimately prove to be better than lungs currently being transplanted from conventional brain-dead organ donors.
authors: Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
authors: T M
authors: TM
authors: Egan
authors: Lung Banks of America, Chapel Hill, NC.
authors: J J
authors: JJ
authors: Requard
mesh_terms: D002423:Cause of Death; D006801:Humans; D016040:Lung Transplantation; D012769:Shock; D013030:Spain; D014019:Tissue Donors; D009927:Tissue and Organ Procurement; D014481:United States
keywords: Clinical trial; donation after circulatory death (DCD); donors and donation; dysfunction; editorial; ethics; ethics and public policy; lung (allograft) function; lung transplantation; organ perfusion and preservation; organ procurement and allocation; organ transplantation in general; personal viewpoint; pulmonology