title: Hormesis within a mechanistic context.
abstract: This paper provides an assessment of the mechanistic foundations of hormesis and how such understandings evolved over the course of the past century. Particular emphasis is placed on recent developments particularly with respect to receptor-based and cell signaling-based pathways. Of particular importance is that the quantitative feature of the hormetic dose response are independent of mechanism.
authors: Department of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: edwardc@schoolph.umass.edu.
authors: Edward J
authors: EJ
authors: Calabrese
mesh_terms: D004305:Dose-Response Relationship, Drug; D006705:Homeopathy / Q000379:methods*; D059165:Hormesis / Q000187:drug effects*; D006801:Humans
keywords: Adaptive response; Biphasic; Dose–response; Hormesis; U-shaped