title: Chronic myelomonocytic leukemia: Forefront of the field in 2015.
abstract: Chronic myelomonocytic leukemia (CMML) includes components of both myelodysplastic syndrome and myeloproliferative neoplasms and is associated with a characteristic peripheral monocytosis. CMML is caused by the proliferation of an abnormal hematopoietic stem cell clone and may be influenced by microenvironmental changes. The disease is rare and has undergone revisions in its classification. We review the recent classification strategies as well as diagnostic criteria, focusing on CMML's genetic alterations and unique pathophysiology. We also discuss the latest molecular characterization of the disease, including how molecular factors affect current prognostic models. Finally, we focus on available treatment strategies, with a special emphasis on experimental and forthcoming therapies.
authors: Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Christopher B
authors: CB
authors: Benton
authors: Leukemia Program, Department of Hematologic Oncology and Blood Disorders, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
authors: Aziz
authors: A
authors: Nazha
authors: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors: Naveen
authors: N
authors: Pemmaraju
authors: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: ggarciam@mdanderson.org.
authors: Guillermo
authors: G
authors: Garcia-Manero
mesh_terms: D006412:Hematopoietic Stem Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D009190:Myelodysplastic Syndromes / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D055153:Stem Cell Niche; D059016:Tumor Microenvironment
keywords: Chronic myelomonocytic leukemia; Myelodysplastic syndrome; Myeloproliferative neoplasms