title: Zebrafish xenotransplantation as a tool for in vivo cancer study.
abstract: Zebrafish represents a powerful model for cancer research. Particularly, the xenotransplantation of human cancer cells into zebrafish has enormous potential for further evaluation of cancer progression and drug discovery. Various cancer models have been established in adults, juveniles and embryos of zebrafish. This xenotransplantation zebrafish model provides a unique opportunity to monitor cancer proliferation, tumor angiogenesis, metastasis, self-renewal of cancer stem cells, and drug response in real time in vivo. This review summarizes the use of zebrafish as a model for cancer xenotransplantation, and highlights its advantages and disadvantages.
authors: Mie University Graduate School of Medicine, Tsu, Japan.
authors: Beibei
authors: B
authors: Zhang
authors: Chao
authors: C
authors: Xuan
authors: Yunxi
authors: Y
authors: Ji
authors: Weiming
authors: W
authors: Zhang
authors: Daogang
authors: D
authors: Wang
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D006801:Humans; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000473:pathology; D014411:Neoplastic Stem Cells; D009389:Neovascularization, Pathologic; D014183:Transplantation, Heterologous; D023041:Xenograft Model Antitumor Assays; D015027:Zebrafish