title: Infertility and the presence of insulin resistance are associated with increased oxidative stress in young, non-obese Turkish women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate the relationship between both insulin resistance and fertility and the oxidant/antioxidant system in young, non-obese patients diagnosed with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Department of Obstetrics and Gynecology, Ege University, Izmir, Turkey.
  
  
  METHODS
  PCOS patients without insulin resistance (IR-) (n = 33), PCOS patients with insulin resistance (IR+) (n = 27), and healthy controls (n = 30). Patients with PCOS and regular sexual intercourse were further divided into infertile (n = 14) and fertile (n = 15) groups.
  
  
  METHODS
  The malondialdehyde (MDA) and thiol levels as well as the catalase (CAT) and superoxide dismutase (SOD) enzyme activities.
  
  
  RESULTS
  Both IR+ and IR- PCOS patients had higher MDA levels and lower thiol levels when compared to the controls (each P < .001). However, only IR- patients had significantly higher SOD (3700.81 ± 410.13 vs 2614.19 ± 611.80 U/g Hb; P < .001) and CAT (7565.06 ± 628.27 vs 6819.61 ± 539.2 U/g Hb; P < .001) activities when compared to the controls. Infertile PCOS patients had significantly higher MDA levels (347.5 ± 22.8 vs 278.6 ± 42.6 nmol/g Hb, P < .001) and lower thiol levels (498.5 ± 56.2 vs 568.5 ± 38.6 μmol/l, P = .001) when compared to fertile patients.
  
  
  CONCLUSIONS
  The results of this study demonstrated an imbalance in the oxidative-antioxidative system of PCOS patients. This imbalance was worse in IR+ and infertile PCOS patients.
authors: Department of Obstetrics and Gynecology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey. Electronic address: volkanturan@yahoo.com.
authors: Volkan
authors: V
authors: Turan
authors: Department of Medical Biochemistry, Ege University Faculty of Medicine, Izmir, Turkey.
authors: Ebru Demirel
authors: ED
authors: Sezer
authors: Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey.
authors: Burak
authors: B
authors: Zeybek
authors: Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey.
authors: Fatih
authors: F
authors: Sendag
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000150:complications*; D007333:Insulin Resistance; D008315:Malondialdehyde / Q000097:blood; D024821:Metabolic Syndrome / Q000150:complications; D018384:Oxidative Stress; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D013438:Sulfhydryl Compounds / Q000097:blood; D014421:Turkey
chemical_list: D000975:Antioxidants; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde
keywords: Fertility; Insulin resistance; Oxidant-antioxidant status; Polycystic ovary syndrome