title: Aspergillosis superinfection as a cause of death of crizotinib-induced interstitial lung disease successfully treated with high-dose corticosteroid therapy.
abstract: Crizotinib is an efficacious and well-tolerated drug in the management of ALK-positive lung cancer. Crizotinib treatment, however, is rarely complicated by the occurrence of acute interstitial lung disease (ILD) that is often fatal. There is no treatment for this serious adverse event. We report a female non-small cell lung cancer patient who developed ILD after a few days of crizotinib therapy. She showed a significant improvement after a high dose of pulse corticosteroid therapy, both radiologically and clinically. Unfortunately, the patient subsequently developed an aspergillosis superinfection leading to death. Our experience suggests that high-dose steroid therapy may be efficacious in the management of a severe complication of crizotinib therapy. However, potent antifungal therapy should be considered to prevent the risk of severe aspergillosis.
authors: Department of Medical Oncology, Centre Hospitalier, Montelimar, France.
authors: Laura
authors: L
authors: Deiana
authors: Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, Brescia, Italy.
authors: Salvatore
authors: S
authors: Grisanti
authors: Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, Brescia, Italy.
authors: Vittorio
authors: V
authors: Ferrari
authors: Section of Anatomic Pathology, Oncology and Experimental Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
authors: Andrea
authors: A
authors: Tironi
authors: Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, Brescia, Italy.
authors: Giulia
authors: G
authors: Brugnoli
authors: Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, Brescia, Italy.
authors: Laura
authors: L
authors: Ferrari
authors: Pneumology Unit, Spedali Civili Hospital, University of Brescia, Brescia, Italy.
authors: Giordano
authors: G
authors: Bozzola
authors: Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, Medical Oncology, Brescia, Italy.
authors: Alfredo
authors: A
authors: Berruti
keywords: Acute interstitial lung disease; Crizotinib; Non-small cell lung cancer