title: Gray matter atrophy is associated with functional connectivity reorganization during the Paced Auditory Serial Addition Test (PASAT) execution in Multiple Sclerosis (MS).
abstract: OBJECTIVE
  We explored the relationship between gray matter atrophy and reorganization of functional connectivity in multiple sclerosis patients during execution of the Paced Auditory Serial Addition Test (PASAT).
  
  
  METHODS
  Seventeen patients and 15 healthy controls were selected for the study. Atrophy was determined using voxel-based morphometry, and atrophy-related connectivity changes were assessed using psychophysiological interaction analysis. Group differences, and correlations with PASAT performance and radiological variables were also examined.
  
  
  RESULTS
  Gray matter atrophy in MS patients was circumscribed to the bilateral posterior cingulate gyrus/precuneus. Compared with controls, patients showed stronger connectivity between the left posterior cingulate gyrus/precuneus, and the left middle temporal gyrus and left cerebellum. A regression analysis in controls showed a negative correlation between PASAT scores and functional connectivity between: (1) the left posterior cingulate gyrus/precuneus, and left pre/postcentral gyri and left occipital gyrus, and (2) the right posterior cingulate gyrus/precuneus, and bilateral cerebellum and left pre/postcentral gyri. Patients showed a negative correlation between brain parenchymal fraction and functional connectivity between the left posterior cingulate gyrus/precuneus and left cerebellum.
  
  
  CONCLUSIONS
  Patients with early MS and little brain damage presented more connectivity during PASAT execution, which may be interpreted as compensatory processes that help preserve cognitive functions.
authors: Universitat Jaume I, Campus Riu Sec, Fac. Ciències de la Salut, Departament de Psicología Bàsica, Clínica i Psicobiología, Avd. Sos Baynat s/n, 12071 Castelló de la Plana, Spain.
authors: Sabina Anna
authors: SA
authors: Baltruschat
authors: Universitat Jaume I, Campus Riu Sec, Fac. Ciències de la Salut, Departament de Psicología Bàsica, Clínica i Psicobiología, Avd. Sos Baynat s/n, 12071 Castelló de la Plana, Spain.
authors: Noelia
authors: N
authors: Ventura-Campos
authors: Universitat Jaume I, Campus Riu Sec, Fac. Ciències de la Salut, Departament de Psicología Bàsica, Clínica i Psicobiología, Avd. Sos Baynat s/n, 12071 Castelló de la Plana, Spain.
authors: Álvaro Javier
authors: ÁJ
authors: Cruz-Gómez
authors: Hospital General de Castellón, Servicio de Neurología, Castelló de la Plana, Spain.
authors: Antonio
authors: A
authors: Belenguer
authors: Universitat Jaume I, Campus Riu Sec, Fac. Ciències de la Salut, Departament de Psicología Bàsica, Clínica i Psicobiología, Avd. Sos Baynat s/n, 12071 Castelló de la Plana, Spain. Electronic address: forn@psb.uji.es.
authors: Cristina
authors: C
authors: Forn
mesh_terms: D000328:Adult; D001284:Atrophy / Q000473:pathology / Q000523:psychology; D001921:Brain / Q000473:pathology*; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology* / Q000523:psychology; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology*; D055815:Young Adult
keywords: Compensatory processes; Functional connectivity; Gray matter (GM) atrophy; Multiple sclerosis (MS); Paced Auditory Serial Addition Test (PASAT)