title: Psoralea glandulosa as a potential source of anticancer agents for melanoma treatment.
abstract: With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on melanoma cancer, the present study was undertaken to investigate the biological activity of the resinous exudate of aerial parts from Psoralea glandulosa, and its active components (bakuchiol (1), 3-hydroxy-bakuchiol (2) and 12-hydroxy-iso-bakuchiol (3)) against melanoma cells (A2058). In addition, the effect in cancer cells of bakuchiol acetate (4), a semi-synthetic derivative of bakuchiol, was examined. The results obtained show that the resinous exudate inhibited the growth of cancer cells with IC50 value of 10.5 μg/mL after 48 h of treatment, while, for pure compounds, the most active was the semi-synthetic compound 4. Our data also demonstrate that resin is able to induce apoptotic cell death, which could be related to an overall action of the meroterpenes present. In addition, our data seem to indicate that the apoptosis correlated to the tested products appears, at least in part, to be associated with an increase of reactive oxygen species (ROS) production. In summary, our study provides the first evidence that P. glandulosa may be considered a source of useful molecules in the development of analogues with more potent efficacy against melanoma cells.
authors: Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, 2340000 Valparaíso, Chile. alejandro.madrid@upla.cl.
authors: Alejandro
authors: A
authors: Madrid
authors: Department of Biomedical Sciences, University of Catania, V. le A. Doria 6, 95125 Catania, Italy. cardile@unict.it.
authors: Venera
authors: V
authors: Cardile
authors: Departamento de Química, Universidad Técnica Federico Santa María, Av. España N° 1680, 2340000 Valparaíso, Chile. cesar.gonzalez@usm.cl.
authors: César
authors: C
authors: González
authors: Escuela de Obstetricia y Puericultura, Facultad de medicina, Universidad de Valparaíso, Blanco N° 1911, 2340000 Valparaíso, Chile. ivan.montenegro@uv.cl.
authors: Ivan
authors: I
authors: Montenegro
authors: Centro de Investigaciones Biomédicas (CIB), Escuela de Medicina, Universidad de Valparaíso, Av. Hontaneda N° 2664, 2340000 Valparaíso, Chile. juan.villena@uv.cl.
authors: Joan
authors: J
authors: Villena
authors: Department of Biomedical Sciences, University of Catania, V. le A. Doria 6, 95125 Catania, Italy. silviacaggia@alice.it.
authors: Silvia
authors: S
authors: Caggia
authors: Department of Biomedical Sciences, University of Catania, V. le A. Doria 6, 95125 Catania, Italy. acegraziano@tiscali.it.
authors: Adriana
authors: A
authors: Graziano
authors: Department of Drug Sciences, Biochemistry Section, University of Catania, V. le A. Doria 6, 95125 Catania, Italy. alrusso@unict.it.
authors: Alessandra
authors: A
authors: Russo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D029907:Psoralea / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012116:Resins, Plant / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D010636:Phenols; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D012116:Resins, Plant; C012765:bakuchiol