title: pH-Sensitive gold nanoclusters: preparation and analytical applications for urea, urease, and urease inhibitor detection.
abstract: Herein, we reported for the first time a facile synthetic process of gold nanoclusters (AuNCs) by using N-acetyl-L-cysteine both as a reducing agent and as a protection ligand. Based on the pH stimuli-responsive properties of the as-prepared AuNCs, we constructed a pH-sensing platform for the detection of urea, urease, and urease inhibitors.
authors: Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004, China. chenandhu@163.com.
authors: Hao-Hua
authors: HH
authors: Deng
authors: Gang-Wei
authors: GW
authors: Wu
authors: Zhi-Qiang
authors: ZQ
authors: Zou
authors: Hua-Ping
authors: HP
authors: Peng
authors: Ai-Lin
authors: AL
authors: Liu
authors: Xin-Hua
authors: XH
authors: Lin
authors: Xing-Hua
authors: XH
authors: Xia
authors: Wei
authors: W
authors: Chen
mesh_terms: D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000032:analysis* / Q000494:pharmacology; D006046:Gold / Q000737:chemistry*; D016480:Helicobacter pylori / Q000201:enzymology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014508:Urea / Q000032:analysis*; D014510:Urease / Q000032:analysis* / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D006046:Gold; D014508:Urea; D014510:Urease