title: N-cadherin-based adherens junction regulates the maintenance, proliferation, and differentiation of neural progenitor cells during development.
abstract: This review addresses our current understanding of the regulatory mechanism by which N-cadherin, a classical cadherin, affects neural progenitor cells (NPCs) during development. N-cadherin is responsible for the integrity of adherens junctions (AJs), which develop in the sub-apical region of NPCs in the neural tube and brain cortex. The apical domain, which contains the sub-apical region, is involved in the switching from symmetric proliferative division to asymmetric neurogenic division of NPCs. In addition, N-cadherin-based AJ is deeply involved in the apico-basal polarity of NPCs and the regulation of Wnt-β-catenin, hedgehog (Hh), and Notch signaling. In this review, we discuss the roles of N-cadherin in the maintenance, proliferation, and differentiation of NPCs through components of AJ, β-catenin and αE-catenin.
authors: a The Graduate School of Humanities and Sciences; Ochanomizu University ; Tokyo , Japan.
authors: Yasunori
authors: Y
authors: Miyamoto
authors: Fumi
authors: F
authors: Sakane
authors: Kei
authors: K
authors: Hashimoto
mesh_terms: D022005:Adherens Junctions / Q000502:physiology*; D000818:Animals; D015820:Cadherins / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D016764:Cell Polarity; D049109:Cell Proliferation / Q000502:physiology*; D053823:Hedgehog Proteins / Q000502:physiology; D006801:Humans; D051379:Mice; D058953:Neural Stem Cells / Q000166:cytology*; D054259:Neural Tube / Q000502:physiology; D015398:Signal Transduction; D051176:beta Catenin / Q000502:physiology
chemical_list: D015820:Cadherins; D053823:Hedgehog Proteins; D051176:beta Catenin
keywords: AJ, adherens junction; EC, extracellular; Fox, forkhead box; Frz, frizzled; GFAP, glial fibrillary acidic protein; GSK3β, glycogen synthase kinase 3β; Hes, hairly/enhancer of split; Hh, hedgehog; IP, intermediate progenitor; KO, knockout; LEF, lymphocyte enhancer factor; N-cadherin; NPC, neural progenitor cell; Par, partition defective complex protein; Ptc, Pached; Smo, smoothened; Sox2, sry (sex determining region Y)-box containing gene 2; TA cell, transient amplifying cell; ZO-1, Zonula Occludens-1.; TCF, T-cell factor; aPKC, atypical protein kinase C; adherens junction; apico-basal polarity; iPSC, induced pluripotent stem cell; neural progenitor cells; ngn2, neurogenin 2; shRNA, short hairpin RNA; β-catenin