title: Serum metabolites as potential biomarkers for diagnosis of knee osteoarthritis.
abstract: Knee osteoarthritis (OA) is a highly prevalent chronic degenerative joint disease that mainly affects the elderly population. The aim of this study was to investigate serum signature metabolites as potential biomarkers for early diagnosis of knee OA. Global serum metabolic profiles of 40 patients with knee OA and 20 healthy controls (HC) were analyzed by ultra-performance liquid chromatography coupled to mass spectrometry. An OA-specific metabolic profile was established that can clearly discriminate patients with OA from HCs. Fourteen metabolites that are involved in the metabolism of amino acids, purine, energy, glycolysis, fatty acids, and lipids were significantly altered in patients with OA compared to HCs. These metabolites could be potentially used as biomarkers for the diagnosis of knee OA.
authors: Department of Orthopedics, The General Hospital of Chinese Army, Beijing 100853, China.
authors: Qingmeng
authors: Q
authors: Zhang
authors: Department of Orthopedics, The General Hospital of Chinese Army, Beijing 100853, China.
authors: Heng
authors: H
authors: Li
authors: Department of Orthopedics, The General Hospital of Chinese Army, Beijing 100853, China.
authors: Zhendong
authors: Z
authors: Zhang
authors: Department of Orthopedics, The General Hospital of Chinese Army, Beijing 100853, China.
authors: Fan
authors: F
authors: Yang
authors: Department of Orthopedics, The General Hospital of Chinese Army, Beijing 100853, China.
authors: Jiying
authors: J
authors: Chen
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood*
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D005227:Fatty Acids