title: Calnexin bridges the gap toward a pan-fungal vaccine.
abstract: Vaccines are needed to combat the global rise in fungal diseases. In this issue of Cell Host & Microbe, Wüthrich et al. (2015) identify calnexin as a target of antigen-specific CD4 T cell responses against multiple fungal pathogens. This study illustrates that a conserved epitope triggers convergent cell-mediated immune responses to confer heterologous antifungal immunity.
authors: Center for Immunity and Inflammation, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA. Electronic address: riveraam@njms.rutgers.edu.
authors: Amariliz
authors: A
authors: Rivera
authors: Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA. Electronic address: hohlt@mskcc.org.
authors: Tobias M
authors: TM
authors: Hohl
mesh_terms: D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology*; D001203:Ascomycota / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology*; D037281:Calnexin / Q000276:immunology*; D049109:Cell Proliferation / Q000187:drug effects*; D000939:Epitopes / Q000276:immunology*
chemical_list: D000946:Antigens, Fungal; D000939:Epitopes; D037281:Calnexin