title: Is There a Link Between Expression Levels of Histone Deacetylase/Acetyltransferase in Mouse Sperm and Subsequent Blastocyst Development?
abstract: Histone acetylation has been known to be significant in spermatogenesis. Histone acetylation is regulated by the act of histone deacetylases (HDACs) and histone acetyltransferases (HATs). We investigated the link between expression levels of HDACs and HATs in mouse sperm and subsequent blastocyst formation rate. In the univariate analysis, expression levels of HDAC1 and HAT were generally not associated with the blastocyst formation rate. When divided by the mature oocyte number category, a significant positive association was observed between the expression levels of HDAC1 and the blastocyst-forming rate in the highest (> 75th) percentile group (a group with ≥34 mature oocytes). In conclusion, expression of sperm HDAC1 could be considered as a possible predictor of embryo development in mice with high ovarian response.
authors: Department of Obstetrics and Gynecology, Cha Gangnam Hospital, Cha University, Seoul, South Korea Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea.
authors: Jayeon
authors: J
authors: Kim
authors: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Bundang, South Korea.
authors: Ji-Hee
authors: JH
authors: Kim
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, South Korea blasto@snubh.org.
authors: Byung-Chul
authors: BC
authors: Jee
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, South Korea.
authors: Chang-Suk
authors: CS
authors: Suh
authors: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Bundang, South Korea.
authors: Seok-Hyun
authors: SH
authors: Kim
mesh_terms: D000107:Acetylation; D000818:Animals; D001755:Blastocyst / Q000378:metabolism / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D051548:Histone Acetyltransferases / Q000378:metabolism*; D056284:Histone Deacetylase 1 / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D008297:Male; D051379:Mice; D009865:Oocytes / Q000502:physiology; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000201:enzymology*
chemical_list: D006657:Histones; D051548:Histone Acetyltransferases; C484389:Hdac1 protein, mouse; D056284:Histone Deacetylase 1
keywords: blastocyst; histone acetylation; histone deacetylase; mouse; sperm