title: MDM2 antagonist clinical response association with a gene expression signature in acute myeloid leukaemia.
authors: Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA. hua.zhong@roche.com.
authors: Hua
authors: H
authors: Zhong
authors: Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA.
authors: Gong
authors: G
authors: Chen
authors: Translational Medicine Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA.
authors: Lori
authors: L
authors: Jukofsky
authors: Translational Medicine Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA.
authors: David
authors: D
authors: Geho
authors: Division of Biostatistics, Departments of Population Health, New York University School of Medicine, New York, NY, USA.
authors: Sung Won
authors: SW
authors: Han
authors: Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Penzberg, Penzberg, Germany.
authors: Fabian
authors: F
authors: Birzele
authors: Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Penzberg, Penzberg, Germany.
authors: Sabine
authors: S
authors: Bader
authors: Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Penzberg, Penzberg, Germany.
authors: Lucia
authors: L
authors: Himmelein
authors: Informatics, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA.
authors: James
authors: J
authors: Cai
authors: Informatics, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA.
authors: Zayed
authors: Z
authors: Albertyn
authors: Biometrics, Product Development, Roche Innovation Center New York, New York, NY, USA.
authors: Mark
authors: M
authors: Rothe
authors: Pharmaceutical Sciences, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
authors: Laurent
authors: L
authors: Essioux
authors: Discovery Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Penzberg, Penzberg, Germany.
authors: Helmut
authors: H
authors: Burtscher
authors: Translational Medicine Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA.
authors: Steven A
authors: SA
authors: Middleton
authors: Translational Medicine Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Penzberg, Penzberg, Germany.
authors: Ruediger
authors: R
authors: Rueger
authors: Translational Medicine Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA.
authors: Lin-Chi
authors: LC
authors: Chen
authors: Discovery Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Penzberg, Penzberg, Germany.
authors: Markus
authors: M
authors: Dangl
authors: Translational Medicine Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA.
authors: Gwen
authors: G
authors: Nichols
authors: Translational Medicine Oncology, Roche Pharmaceutical Research and Early Development, Roche Innovation Center New York, New York, NY, USA.
authors: William E
authors: WE
authors: Pierceall
mesh_terms: D000328:Adult; D000368:Aged; D045744:Cell Line, Tumor; D005260:Female; D020869:Gene Expression Profiling; D015973:Gene Expression Regulation, Leukemic / Q000187:drug effects*; D006801:Humans; D048288:Imidazolines / Q000008:administration & dosage* / Q000009:adverse effects; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D051736:Proto-Oncogene Proteins c-mdm2 / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D048288:Imidazolines; C579783:RG7112; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2
keywords: MDM2 antagonist; TP53; acute myeloid leukaemia; diagnostic algorithm; gene expression signature