title: Direct Aqueous Self-Assembly of an Amphiphilic Diblock Copolymer toward Multistimuli-Responsive Fluorescent Anisotropic Micelles.
abstract: It is extremely important for emerging applications and still enormously challenging to develop multifunctional stimuli-responsive anisotropic polymeric micelles with integration of potentially targeted therapeutic and diagnostic function. Herein, we report a first example of fluorescent anisotropic micelles (FAMs) with Fe(3+), DTT, H2O2, and thermal responsive fluorescence and morphology. FAMs from direct aqueous self-assembly of amphiphilic diblock copolymer showed reversible "switch off/on" of aqua fluorescent emission and controllable structural change by sequential addition of Fe(3+) and DTT. In addition, the FAMs had reversible dual-thermal responsiveness of fluorescence and morphology. This micelle could serve as a promising candidate for all-in-one application of quantitative detecting, imaging, drug delivery, and targeted release.
authors: †Center for Degradable and Flame-Retardant Polymeric Materials (ERCEPM-MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610064, China.|‡School of Energy Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China.
authors: Gang
authors: G
authors: Wu
authors: †Center for Degradable and Flame-Retardant Polymeric Materials (ERCEPM-MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
authors: Si-Chong
authors: SC
authors: Chen
authors: †Center for Degradable and Flame-Retardant Polymeric Materials (ERCEPM-MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
authors: Chang-Lei
authors: CL
authors: Liu
authors: †Center for Degradable and Flame-Retardant Polymeric Materials (ERCEPM-MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, Sichuan 610064, China.
authors: Yu-Zhong
authors: YZ
authors: Wang
mesh_terms: D004146:Dioxanes / Q000737:chemistry*; D004229:Dithiothreitol / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D005454:Fluorescence Polarization; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007501:Iron / Q000737:chemistry; D008823:Micelles; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D004146:Dioxanes; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers; D014867:Water; C079733:poly-4-dioxan-2-one; D011092:Polyethylene Glycols; D007501:Iron; D004229:Dithiothreitol
keywords: block copolymers; fluorescent; micelles; self-assembly; shape anisotropy; stimuli-responsive