title: Unexpected Synthesis of 5,6-Dihydropyridin-2(1H)-ones by a Domino Ugi/Aldol/Hydrolysis Reaction Starting from Baylis-Hillman Phosphonium Salts.
abstract: A one-pot synthetic approach to 5,6-dihydropyridin-2(1H)-ones has been developed using a domino process involving Ugi, aldol, and hydrolysis reactions, starting with Baylis-Hillman phosphonium salts, primary amines, isocyanides, and arylglyoxals.
authors: ‡Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, P. R. China.
authors: Xiao-Hua
authors: XH
authors: Zeng
authors: ‡Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, Hubei University of Medicine, Shiyan 442000, P. R. China.
authors: Hong-Mei
authors: HM
authors: Wang
authors: Ming-Wu
authors: MW
authors: Ding
mesh_terms: D000588:Amines / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D006868:Hydrolysis; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D003486:Cyanides; D009943:Organophosphorus Compounds; D011728:Pyridones; C080146:phosphonium salt II-41