title: Allograft adenovirus nephritis.
abstract: We present an uncommon case of allograft adenovirus tubulointerstitial nephritis in a 63-year-old male 6 weeks following cadaveric renal transplantation for end-stage renal failure secondary to hypertensive nephrosclerosis. The patient presented with acute onset of fevers, dysuria, haematuria and diarrhoea with acute graft dysfunction. A renal biopsy demonstrated necrotizing tubulointerstitial nephritis with viral cytopathic changes and no evidence of rejection. Adenovirus was identified as the pathogen. Treatment involved the reduction in the patient's usual immunosuppression, intravenous immunoglobulin, piperacillin-tazobactam and ganciclovir. We present the clinical and pathological findings of necrotizing adenoviral nephropathy, highlighting the importance of considering this diagnosis in renal transplant recipients presenting with interstitial nephritis in the setting of a systemic illness.
authors: Department of Nephrology , The Canberra Hospital , Canberra, ACT , Australia.
authors: Kirsty
authors: K
authors: Rady
authors: Department of Nephrology , The Canberra Hospital , Canberra, ACT , Australia.
authors: Giles
authors: G
authors: Walters
authors: Department of Pathology , The Canberra Hospital , Canberra, ACT , Australia.
authors: Michael
authors: M
authors: Brown
authors: Department of Nephrology , The Canberra Hospital , Canberra, ACT , Australia.
authors: Girish
authors: G
authors: Talaulikar
keywords: adenovirus; nephritis; renal; transplant