title: Systems vaccinology: Enabling rational vaccine design with systems biological approaches.
abstract: Vaccines have drastically reduced the mortality and morbidity of many diseases. However, vaccines have historically been developed empirically, and recent development of vaccines against current pandemics such as HIV and malaria has been met with difficulty. The advent of high-throughput technologies, coupled with systems biological methods of data analysis, has enabled researchers to interrogate the entire complement of a variety of molecular components within cells, and characterize the myriad interactions among them in order to model and understand the behavior of the system as a whole. In the context of vaccinology, these tools permit exploration of the molecular mechanisms by which vaccines induce protective immune responses. Here we review the recent advances, challenges, and potential of systems biological approaches in vaccinology. If the challenges facing this developing field can be overcome, systems vaccinology promises to empower the identification of early predictive signatures of vaccine response, as well as novel and robust correlates of protection from infection. Such discoveries, along with the improved understanding of immune responses to vaccination they impart, will play an instrumental role in development of the next generation of rationally designed vaccines.
authors: Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
authors: Thomas
authors: T
authors: Hagan
authors: School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Department of Pathology, Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
authors: Helder I
authors: HI
authors: Nakaya
authors: Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA; Department of Nanoengineering, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
authors: Shankar
authors: S
authors: Subramaniam
authors: Department of Pathology, Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA; Yerkes National Primate Research Center, Atlanta, GA, USA. Electronic address: bpulend@emory.edu.
authors: Bali
authors: B
authors: Pulendran
mesh_terms: D000818:Animals; D066264:Datasets as Topic; D006801:Humans; D049490:Systems Biology / Q000379:methods*; D059467:Transcriptome; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines
keywords: Systems biology; Systems vaccinology; Vaccines