title: Endothelial Function in Patients with Hematologic Malignancies Undergoing High-Dose Chemotherapy Followed by Hematopoietic Stem Cell Transplantation.
abstract: The aim of the study was to examine endothelial function in patients with hematological malignancies treated with high-dose chemotherapy followed by hematopoietic stem cell transplantation. The studies were conducted on 43 consecutive patients qualified for HSCT following high-dose chemotherapy based on the current standards. Then, due to exclusion criteria, a group of 38 patients were chosen for further investigations. Evaluation of endothelial function by means of flow-mediated dilatation (FMD) was conducted in patients with hematological malignancies before HSCT (test A) and after HSCT (test B). Brachial artery diameter (BAD) after occlusion, change in BAD and FMD were significantly lower after HSCT as compared to the results obtained before the transplantation (p < 0.05). The regression analysis indicated that administration of fludarabine and cytarabine, and also higher blood concentrations of creatinine represented risk factors for the impairment of endothelial function expressed as decreased FMD value. In patients with hematopoietic malignancies treated with HSCT, endothelial function assessed by the flow-mediated dilatation was impaired after chemotherapy and stem cell administration.
authors: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1 Street, 50-368, Wrocław, Poland.
authors: Małgorzata
authors: M
authors: Poręba
authors: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1 Street, 50-368, Wrocław, Poland. pawelgac@interia.pl.
authors: Paweł
authors: P
authors: Gać
authors: Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Pasteur 4, 50-367, Wrocław, Poland.
authors: Lidia
authors: L
authors: Usnarska-Zubkiewicz
authors: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1 Street, 50-368, Wrocław, Poland.
authors: Witold
authors: W
authors: Pilecki
authors: Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Pasteur 4, 50-367, Wrocław, Poland.
authors: Kazimierz
authors: K
authors: Kuliczkowski
authors: Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, 50-556, Wrocław, Poland.
authors: Grzegorz
authors: G
authors: Mazur
authors: Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1 Street, 50-368, Wrocław, Poland.
authors: Małgorzata
authors: M
authors: Sobieszczańska
authors: Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Borowska 213, 50-556, Wrocław, Poland.
authors: Rafał
authors: R
authors: Poręba
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005260:Female; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000639:trends; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents
keywords: Brachial artery; Endothelium; Hematopoietic stem cell transplantation; Ultrasonography