title: Proteomics - The research frontier in periodontics.
abstract: Periodontitis is an inflammatory condition resulting from the interplay between the infectious agents and host factors. Various protein molecules play a vital role in the initiation, progression and severity of periodontal diseases. The study of proteins as biomarkers in periodontal diseases has been highlighted during the last few years. In periodontitis multiple bacteria derived (e.g. collagen degrading enzymes, elastase like enzymes etc) and host derived mediators (eg. PGE2, TNF, IL1, IL6, MMP's etc) expressed in the saliva and gingival crevicular fluid, can be utilized as diagnostic markers for the disease. Another significant development regarding human genes and proteins has been the discovery of potential new drugs for the treatment of periodontal diseases. Therefore the information of the proteins involved in the pathogenesis of periodontal diseases can be utilized for its diagnosis, prevention and treatment.
authors: MDS (IIIrd Year) Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
authors: Abhaya
authors: A
authors: Gupta
authors: MDS (Professor & Head of Department), Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
authors: Vivek
authors: V
authors: Govila
authors: MDS (Reader), Department of Periodontics, Babu Banarasi Das College of Dental Sciences, Lucknow, India.
authors: Ashish
authors: A
authors: Saini
keywords: Biomarkers; Genome; Periodontitis; Porphyromonas gingivalis; Proteome