title: Clinical applications of iron oxide nanoparticles for magnetic resonance imaging of brain tumors.
abstract: Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors, allowing for improved diagnostic and prognostic capabilities. Some challenges persist even with today's advanced imaging techniques, including accurate delineation of tumor margins and distinguishing treatment effects from residual or recurrent tumor. Ultrasmall superparamagnetic iron oxide nanoparticles are an emerging tool that can add clinically useful information due to their distinct physiochemical features and biodistribution, while having a good safety profile. Nanoparticles can be used as a platform for theranostic drugs, which have shown great promise for the treatment of CNS malignancies. This review will provide an overview of clinical ultrasmall superparamagnetic iron oxides and how they can be applied to the diagnostic and therapeutic neuro-oncologic setting.
authors: Department of Radiology, Stanford University & Stanford University Medical Center, Stanford, CA 94305, USA.
authors: Michael
authors: M
authors: Iv
authors: Nicholas
authors: N
authors: Telischak
authors: Dan
authors: D
authors: Feng
authors: Samantha J
authors: SJ
authors: Holdsworth
authors: Kristen W
authors: KW
authors: Yeom
authors: Heike E
authors: HE
authors: Daldrup-Link
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy; D005290:Ferric Compounds / Q000737:chemistry*; D052203:Ferrosoferric Oxide; D005910:Glioma / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry*; D050997:Nanomedicine / Q000379:methods* / Q000639:trends; D009368:Neoplasm Transplantation; D061214:Patient Safety; D011379:Prognosis; D051381:Rats
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D052203:Ferrosoferric Oxide
keywords: MRI; brain tumor; ferucarbotran; ferumoxtran; ferumoxytol; macrophage; ultrasmall superparamagnetic iron oxide nanoparticles