title: Diabetes mellitus related bone metabolism and periodontal disease.
abstract: Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide. Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus. Alveolar bone loss is one of the main outcomes of periodontitis, and diabetes is among the primary risk factors for periodontal disease. In this review, we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects, focusing on alveolar bone loss. Bone remodelling begins with osteoclasts resorbing bone, followed by new bone formation by osteoblasts in the resorption lacunae. Therefore, we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts.
authors: 1] State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China [2] School of Dental Medicine, University of Pennsylvania, Philadelphia, USA.
authors: Ying-Ying
authors: YY
authors: Wu
authors: 1] School of Dental Medicine, University of Pennsylvania, Philadelphia, USA [2] Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.
authors: E
authors: E
authors: Xiao
authors: School of Dental Medicine, University of Pennsylvania, Philadelphia, USA.
authors: Dana T
authors: DT
authors: Graves
mesh_terms: D001847:Bone Diseases / Q000150:complications / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D006801:Humans; D010510:Periodontal Diseases / Q000150:complications*