title: Dysregulation of microRNAs in angioimmunoblastic T-cell lymphoma.
abstract: BACKGROUND
  Angioimmunoblastic T-cell lymphomas (AITLs) are the second most frequent peripheral T-cell lymphomas in humans worldwide and histomorphologically well characterized. MicroRNAs are a group of small non-coding RNAs that can negatively regulate gene expression on a posttranscriptional level. Their dysregulation has been shown to be of importance in numerous tumour entities.
  
  
  METHODS
  As a first step towards understanding the possible influence of microRNA-dysregulation in AITL, we analyzed the expression signatures of 760 microRNAs in 30 nodal AITLs in comparison to reactive lymphadenitis with T-zone hyperplasia.
  
  
  RESULTS
  We found miR-34a, miR-146a and miR-193b to be up-regulated, as well as miR-140-3p, let-7g, miR-30b and miR-664 to be down-regulated in AITL to a significant level.
  
  
  CONCLUSIONS
  The microRNA-signatures of AITL reveal some overlap to autoimmune diseases, virus-triggered lymphomas and angiogenic factors that, coupled with future studies, will potentially provide better understanding of this disease.
authors: Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany Katharina.Reddemann@uksh.de.
authors: Katharina
authors: K
authors: Reddemann
authors: Institute of Medical Biometry and Statistics, University Luebeck, Luebeck, Germany.
authors: Damian
authors: D
authors: Gola
authors: Institute of Medical Biometry and Statistics, University Luebeck, Luebeck, Germany.
authors: Arne
authors: A
authors: Schillert
authors: Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Juliana
authors: J
authors: Knief
authors: Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Christiane
authors: C
authors: Kuempers
authors: Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Julika
authors: J
authors: Ribbat-Idel
authors: Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Svetlana
authors: S
authors: Ber
authors: Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Janina
authors: J
authors: Schemme
authors: Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Veronica
authors: V
authors: Bernard
authors: Department of Internal Medicine, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Niklas
authors: N
authors: Gebauer
authors: Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Alfred Christian
authors: AC
authors: Feller
authors: Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
authors: Christoph
authors: C
authors: Thorns
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D045744:Cell Line, Tumor; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000235:genetics* / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged
chemical_list: D035683:MicroRNAs
keywords: Angioimmunoblastic T-cell lymphoma; lymphadenitis with T-zone hyperplasia; microRNA