title: Genetic Polymorphisms in the Toll-like Receptor 10, Interleukin (IL)17A and IL17F Genes Differently Affect the Risk for Tuberculosis in Croatian Population.
abstract: Proinflammatory conditions leading to activation of macrophages via interferon-γ bear an important role in host defence against intracellular bacteria such as Mycobacterium tuberculosis (Mt). Interleukin-17 plays a similar role, as it appears to be also an activator of macrophages. Recently, the TLR-10 was identified as an anti-inflammatory factor that exerts its action via association with the TLR-2 chain at the cell surface of macrophages, the latter being an Mt-binding protein. We have previously found that gene polymorphisms that either inactivate the TLR2 gene product or have a dominant-negative role are associated with tuberculosis (TB) in Croatian population. We have now extended our survey and found that single nucleotide polymorphism (SNP) in TLR10 (rs11096957) is associated with risk for TB. Homozygotes carrying the A allele are associated with predisposition to disease as analysed by the dominant model of inheritance. In contrast, SNPs in the proinflammatory IL17A and IL17F genes (rs2275913 and rs763780, respectively), found previously to correlate with the disease occurrence in Chinese population, were not significantly associated with tuberculosis in the Croatian population.
authors: Molecular Genetics Laboratory, Department of Oral Biology, Dental Faculty, University of Oslo, Oslo, Norway.|Department of Pulmology, Clinic for Internal Medicine, Clinical Hospital Center Rijeka, School of Medicine, University of Rijeka, Rijeka, Croatia.
authors: L J
authors: LJ
authors: Bulat-Kardum
authors: Molecular Genetics Laboratory, Department of Oral Biology, Dental Faculty, University of Oslo, Oslo, Norway.
authors: G E
authors: GE
authors: Etokebe
authors: Molecular Genetics Laboratory, Department of Oral Biology, Dental Faculty, University of Oslo, Oslo, Norway.
authors: P
authors: P
authors: Lederer
authors: Clinical Institute for Transfusion Medicine, Clinical Hospital Center Rijeka, School of Medicine, University of Rijeka, Rijeka, Croatia.
authors: S
authors: S
authors: Balen
authors: Molecular Genetics Laboratory, Department of Oral Biology, Dental Faculty, University of Oslo, Oslo, Norway.
authors: Z
authors: Z
authors: Dembic
mesh_terms: D016022:Case-Control Studies; D017523:Croatia / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000276:immunology; D020381:Interleukin-17 / Q000235:genetics*; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology; D020641:Polymorphism, Single Nucleotide; D051201:Toll-Like Receptor 10 / Q000235:genetics*; D014376:Tuberculosis / Q000453:epidemiology* / Q000235:genetics* / Q000276:immunology
chemical_list: C508717:IL17A protein, human; C440021:IL17F protein, human; D020381:Interleukin-17; C475955:TLR10 protein, human; D051201:Toll-Like Receptor 10