title: Beyond 3D culture models of cancer.
abstract: The mechanisms underlying the spatiotemporal evolution of tumor ecosystems present a challenge in evaluating drug efficacy. In this Perspective, we address the use of three-dimensional in vitro culture models to delineate the dynamic interplay between the tumor and the host microenvironment in an effort to attain realistic platforms for assessing pharmaceutical efficacy in patients.
authors: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. mgottesman@nih.gov kandice.tanner@nih.gov.
authors: Kandice
authors: K
authors: Tanner
authors: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. mgottesman@nih.gov kandice.tanner@nih.gov.
authors: Michael M
authors: MM
authors: Gottesman
mesh_terms: D000818:Animals; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology; D018929:Cell Culture Techniques; D003593:Cytoplasm / Q000378:metabolism; D004260:DNA Repair; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D044127:Epigenesis, Genetic; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology*; D046888:Tissue Array Analysis; D023822:Tissue Engineering / Q000379:methods; D059016:Tumor Microenvironment