title: Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
abstract: The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of apoptosis and the transformation and progression of malignant cells. Genetic variations in KIF1B may contribute to risk of epithelial ovarian cancer (EOC). In this study of 1,324 EOC patients and 1,386 cancer-free female controls, we investigated associations between two potentially functional single nucleotide polymorphisms in KIF1B and EOC risk by the conditional logistic regression analysis. General linear regression model was used to evaluate the correlation between the number of variant alleles and KIF1B mRNA expression levels. We found that the rs17401966 variant AG/GG genotypes were significantly associated with a decreased risk of EOC (adjusted odds ratio (OR) = 0.81, 95 % confidence interval (CI) = 0.68-0.97), compared with the AA genotype, but no associations were observed for rs1002076. Women who carried both rs17401966 AG/GG and rs1002076 AG/AA genotypes of KIF1B had a 0.82-fold decreased risk (adjusted 95 % CI = 0.69-0.97), compared with others. Additionally, there was no evidence of possible interactions between about-mentioned co-variants. Further genotype-phenotype correlation analysis indicated that the number of rs17401966 variant G allele was significantly associated with KIF1B mRNA expression levels (P for GLM = 0.003 and 0.001 in all and Chinese subjects, respectively), with GG carriers having the lowest level of KIF1B mRNA expression. Taken together, the rs17401966 polymorphism likely regulates KIF1B mRNA expression and thus may be associated with EOC risk in Eastern Chinese women. Larger, independent studies are warranted to validate our findings.
authors: Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.|Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China.
authors: Ting-Yan
authors: TY
authors: Shi
authors: Department of Gynecologic Oncology, Jiangsu Cancer Hospital, Nanjing, Jiangsu, China.
authors: Zhi
authors: Z
authors: Jiang
authors: Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China.|Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
authors: Rong
authors: R
authors: Jiang
authors: Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China.|Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
authors: Sheng
authors: S
authors: Yin
authors: Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors: Meng-Yun
authors: MY
authors: Wang
authors: Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
authors: Ke-Da
authors: KD
authors: Yu
authors: Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
authors: Zhi-Ming
authors: ZM
authors: Shao
authors: Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China.
authors: Meng-Hong
authors: MH
authors: Sun
authors: Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China. rongyuzang@163.com.|Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. rongyuzang@163.com.
authors: Rongyu
authors: R
authors: Zang
authors: Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. weiqingyi@yahoo.com.|Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. weiqingyi@yahoo.com.|Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA. weiqingyi@yahoo.com.
authors: Qingyi
authors: Q
authors: Wei
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016547:Kinesins / Q000096:biosynthesis / Q000235:genetics*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger / Q000096:biosynthesis; D012307:Risk Factors
chemical_list: C091053:KIF1B protein, human; D012333:RNA, Messenger; D016547:Kinesins
keywords: KIF1B; Ovarian cancer; Polymorphism; Susceptibility