title: Delivery of local therapeutics to the brain: working toward advancing treatment for malignant gliomas.
abstract: Malignant gliomas, including glioblastoma and anaplastic astrocytomas, are characterized by their propensity to invade surrounding brain parenchyma, making curative resection difficult. These tumors typically recur within two centimeters of the resection cavity even after gross total removal. As a result, there has been an emphasis on developing therapeutics aimed at achieving local disease control. In this review, we will summarize the current developments in the delivery of local therapeutics, namely direct injection, convection-enhanced delivery and implantation of drug-loaded polymers, as well as the application of these therapeutics in future methods including microchip drug delivery and local gene therapy.
authors: Department of Neurosurgery, Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed 6007B, Baltimore, MD 21202, USA.
authors: Kaisorn L
authors: KL
authors: Chaichana
authors: Leon
authors: L
authors: Pinheiro
authors: Henry
authors: H
authors: Brem
mesh_terms: D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000628:therapy*; D016503:Drug Delivery Systems; D015316:Genetic Therapy; D005910:Glioma / Q000628:therapy*; D006801:Humans; D011108:Polymers / Q000008:administration & dosage
chemical_list: D011108:Polymers