title: Dietary vitamin D3 improves postprandial hyperglycemia in aged mice.
abstract: Type 2 Diabetes is closely associated with our daily diets and has become a global health problem with an increasing number of patients. Recent observational and randomized studies on vitamin D3 suggested that higher plasma 25-hydroxyvitamin D3 [25(OH)D3] concentrations and more vitamin D3 intake are associated with lower risk of type 2 diabetes, which is characterized by postprandial hyperglycemia due to inappropriate glucose stimulated insulin secretion (GSIS) and its age-dependent increase of onset. However, rapid action of dietary vitamin D3 on the postprandial glucose profile has not been analyzed. When vitamin D3 is orally ingested in mice aged 12-14 weeks during an oral glucose tolerance test (OGTT), the serum glucose profile was not changed. In contrast, when OGTT was performed with old mice aged 30-34 weeks, the glucose profile was dramatically improved with increased insulin secretion, suggesting that orally ingested vitamin D3 potentiated GSIS in aged mice. Interestingly, there was also a significant increase in plasma GLP-1 in these aged mice. Our results suggest that orally ingested dietary vitamin D3 in aged mice improves glucose metabolism as a GLP-1 enhancer.
authors: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan; Universidad Catolica Nuestra Señora de la Asunciòn, Independencia Nacional 176 y Comuneros C.C 1718, Asunción, Paraguay.
authors: Patricio L M
authors: PL
authors: Enciso
authors: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan.
authors: Lixiang
authors: L
authors: Wang
authors: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan.
authors: Yuta
authors: Y
authors: Kawahara
authors: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan.
authors: Shohei
authors: S
authors: Sakamoto
authors: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan.
authors: Shingo
authors: S
authors: Shimada
authors: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan.
authors: Yukina
authors: Y
authors: Takeichi
authors: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan.
authors: Ryoichi
authors: R
authors: Takayanagi
authors: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan. Electronic address: nomura@med.kyushu-u.ac.jp.
authors: Masatoshi
authors: M
authors: Nomura
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002460:Cell Line; D002762:Cholecalciferol / Q000008:administration & dosage*; D019587:Dietary Supplements; D019858:Enteroendocrine Cells / Q000187:drug effects / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007328:Insulin; D002762:Cholecalciferol; D052216:Glucagon-Like Peptide 1
keywords: GLP-1; Insulin secretion; Postprandial hyperglycemia; Vitamin D(3)