title: Changes in retinal oxygen saturation, choroidal thickness, and retinal nerve fibre layer.
abstract: OBJECTIVE
  To investigate the changes of retinal oxygen saturation (Sat O2) concentrations, choroidal thickness (CT), and retinal nerve fibre layer (RNFL) in eyes with trabeculectomy-required acute primary angle closure (APAC).
  
  
  METHODS
  Prospective, longitudinal study.
  
  
  METHODS
  Twenty-three eyes with trabeculectomy-required APAC were recruited.
  
  
  METHODS
  Retinal oximetry was performed at postoperative day one and again at approximately 1 month. CT and the RNFL were tested on the same day. A paired t test and Pearson correlation were used for analysis.
  
  
  RESULTS
  Mean Sat O2 increased in retinal arterioles from 88.74% ± 14.36% at postoperative day 1 to 96.61% ± 18.42% at 1 month (p = 0.049). The mean diameter of the arterioles was statistically different between postoperative day 1 and 1 month (p = 0.044), as was the mean diameter of the venules (p = 0.027). APAC eyes at postoperative 1 month had a thinner mean CT, compared with day 1 (p = 0.002). No significant difference was found in the RNFL between postoperative day 1 and 1 month (p > 0.05). The Sat O2 in retinal arterioles correlated with the mean diameter of the arterioles at postoperative day 1 (r = -0.482, p = 0.020) and at 1 month (r = -0.463, p = 0.026). No significant correlation was found between retinal Sat O2 and other parameters.
  
  
  CONCLUSIONS
  Increased Sat O2 in retinal arterioles, changed vessel diameter, and thinner CT from postoperative day 1 to 1 month suggest gradual recovery from APAC. However, the different pathophysiologies for APAC still need further study to prove.
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors: Shaolin
authors: S
authors: Du
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors: Xinbo
authors: X
authors: Gao
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China. Electronic address: zhangxl2@mail.sysu.edu.cn.
authors: Xiulan
authors: X
authors: Zhang
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors: Jiawei
authors: J
authors: Wang
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors: Wenbin
authors: W
authors: Huang
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors: Minwen
authors: M
authors: Zhou
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors: Wei
authors: W
authors: Wang
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors: Xingyi
authors: X
authors: Li
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors: Yichi
authors: Y
authors: Zhang
authors: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
authors: Dennis S C
authors: DS
authors: Lam
mesh_terms: D000208:Acute Disease; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D002829:Choroid / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D015812:Glaucoma, Angle-Closure / Q000503:physiopathology* / Q000601:surgery; D006068:Gonioscopy; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012171:Retinal Vessels / Q000473:pathology; D041623:Tomography, Optical Coherence; D014130:Trabeculectomy
chemical_list: D010100:Oxygen