title: Crystalloid glomerulopathy in monoclonal gammopathy of renal significance (MGRS).
abstract: We report a case of monoclonal gammopathy of renal significance in a 63-year-old man who presented with nephrotic-range proteinuria and renal insufficiency. The kidney biopsy showed a membranoproliferative glomerulonephritis pattern with extensive crystalloid deposits in the glomerular capillary endothelial cells and very few in the tubular epithelial cells. The immunoperoxidase staining showed kappa light chain restriction. Subsequently, the bone marrow showed 6% plasma cells which confirmed the diagnosis of monoclonal gammopathy of renal significance. He responded well to bortezomib treatment with resolution of the nephrotic syndrome and normalization of renal function after 7 months.
authors: Department of Pathology , Manipal Hospital , Bangalore , India.
authors: Mahesha
authors: M
authors: Vankalakunti
authors: Department of Nephrology , Manipal Hospital , Bangalore , India.
authors: Ravishankar
authors: R
authors: Bonu
authors: Department of Nephrology , Manipal Hospital , Bangalore , India.
authors: Shilpa
authors: S
authors: Shetty
authors: Department of Nephrology , Manipal Hospital , Bangalore , India.
authors: Vishwanath
authors: V
authors: Siddini
authors: Department of Nephrology , Manipal Hospital , Bangalore , India.
authors: Kishore
authors: K
authors: Babu
authors: Department of Nephrology , Manipal Hospital , Bangalore , India.
authors: Sudarshan H
authors: SH
authors: Ballal
keywords: crystalloid glomerulopathy; monoclonal gammopathy of renal significance