title: Complications of Stevens-Johnson syndrome beyond the eye and skin.
abstract: BACKGROUND
  Ocular and cutaneous disease are common chronic sequelae of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and have been well described in the literature. Long-term complications affecting other organ systems have not been so well described. The purpose of this review article is to highlight non-ocular and non-cutaneous chronic complications of SJS/TEN.
  
  
  METHODS
  The PubMed database was searched for the keywords "Stevens-Johnson syndrome" and "toxic epidermal necrolysis" through September 1, 2014. Relevant articles were then reviewed in full.
  
  
  RESULTS
  138 articles in the English language were found that described chronic sequelae of SJS/TEN. Our search revealed six affected organ systems other than the eyes and integument, with chronic sequelae from SJS/TEN: respiratory, gastrointestinal/hepatic, oral, otorhinolaryngologic, gynecologic/genitourinary, and renal. Complications involving these organs systems appeared likely to reduce the quality of life for SJS/TEN survivors.
  
  
  CONCLUSIONS
  SJS/TEN is a multi-organ disease requiring multidisciplinary care from a variety of specialists. Affected patients have complex hospital stays, and their quality of life may be severely impacted by multiple long-term complications. We believe that preventative care in the acute setting might limit the development and progression of many of the sequelae described above.
authors: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St., Boston, MA 02114, USA. Electronic address: Hajirah_Saeed@meei.harvard.edu.
authors: Hajirah
authors: H
authors: Saeed
authors: Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA. Electronic address: Jason.Mantagos@childrens.harvard.edu.
authors: Iason S
authors: IS
authors: Mantagos
authors: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles St., Boston, MA 02114, USA. Electronic address: James_Chodosh@meei.harvard.edu.
authors: James
authors: J
authors: Chodosh
mesh_terms: D002908:Chronic Disease; D005260:Female; D005767:Gastrointestinal Diseases / Q000209:etiology*; D005831:Genital Diseases, Female / Q000209:etiology; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*; D008107:Liver Diseases / Q000209:etiology*; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D052801:Male Urogenital Diseases / Q000209:etiology; D009059:Mouth Diseases / Q000209:etiology*; D010038:Otorhinolaryngologic Diseases / Q000209:etiology*; D011788:Quality of Life; D013262:Stevens-Johnson Syndrome / Q000150:complications*
keywords: Stevens–Johnson syndrome; Toxic epidermal necrolysis