title: Central analgesic activity of the aqueous and ethanolic extracts of the leaves of Albizia lebbeck: role of the GABAergic and serotonergic pathways.
abstract: Albizia lebbeck Benth. is extensively used in Indian traditional medicine for treating several painful and inflammatory disorders. The possible central analgesic activity and the underlying mechanism of action of the aqueous (AE) and ethanolic extracts (EE) of the leaves of A. lebbeck were investigated in Wistar rats using Eddy's hot plate and the tail flick tests. In order to investigate the underlying mechanism of action, rats were pretreated with naloxone, bicuculline or methysergide and then were administered a per os (p.o.) dose of AE or EE. AE and EE caused a significant (p<0.05) elevation in the mean basal reaction time in the hot plate method and an increase in the latency time in the tail flick method. In rats pretreated with bicuculline and methysergide, a significant (p<0.05) reduction in the analgesic activity was observed in comparison to AE and EE. Thus, AE and EE exhibited significant central analgesic activity and act possibly via the GABAergic and serotonergic pathways. The flavonoids and saponins found in the leaves could be responsible for the observed effect.
authors: Girish G
authors: GG
authors: Meshram
authors: Anil
authors: A
authors: Kumar
authors: Waseem
authors: W
authors: Rizvi
authors: C D
authors: CD
authors: Tripathi
authors: R A
authors: RA
authors: Khan
mesh_terms: D031289:Albizzia / Q000737:chemistry; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D000431:Ethanol / Q000737:chemistry*; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D059330:GABAergic Neurons / Q000187:drug effects* / Q000378:metabolism; D010146:Pain / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D017288:Pain Threshold / Q000187:drug effects; D010423:Pentazocine / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D010946:Plants, Medicinal; D017208:Rats, Wistar; D011930:Reaction Time; D059326:Serotonergic Neurons / Q000187:drug effects* / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology; D012997:Solvents / Q000737:chemistry*
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D058787:GABA-A Receptor Antagonists; D010936:Plant Extracts; D012702:Serotonin Antagonists; D012997:Solvents; D000431:Ethanol; D010423:Pentazocine