title: Extensive survey of STAT6 expression in a large series of mesenchymal tumors.
abstract: OBJECTIVE
  Expression of strong nuclear STAT6 is thought to be a specific marker for solitary fibrous tumors (SFTs). Little is known about subtle expression patterns in other mesenchymal lesions.
  
  
  METHODS
  We performed immunohistochemical studies against the C-terminus of STAT6 in tissue microarrays and whole sections, comprising 2366 mesenchymal lesions.
  
  
  RESULTS
  Strong nuclear STAT6 was expressed in 285 of 2,021 tumors, including 206 of 240 SFTs, 49 of 408 well-differentiated/dedifferentiated liposarcomas, eight of 65 unclassified sarcomas, and 14 of 184 desmoid tumors, among others. Expression in SFTs was predominately limited to the nucleus. Other positive tumors typically expressed both nuclear and cytoplasmic STAT6. Complete absence of STAT6 was most common in pleomorphic liposarcoma and alveolar soft part sarcoma (60% and 72% cases negative, respectively).
  
  
  CONCLUSIONS
  Strong nuclear STAT6 is largely specific for SFTs. Physiologic low-level cytoplasmic/nuclear expression is common in mesenchymal neoplasia and is of uncertain significance.
authors: From Pathology, Icahn School of Medicine at Mount Sinai, New York, NY; Elizabeth.Demicco@mountsinai.org.
authors: Elizabeth G
authors: EG
authors: Demicco
authors: Pathology, University of Michigan Medical Center, Ann Arbor; and.
authors: Paul W
authors: PW
authors: Harms
authors: Pathology, University of Michigan Medical Center, Ann Arbor; and.
authors: Rajiv M
authors: RM
authors: Patel
authors: Pathology, University of Michigan Medical Center, Ann Arbor; and.
authors: Steven C
authors: SC
authors: Smith
authors: Pathology.
authors: Davis
authors: D
authors: Ingram
authors: Sarcoma Research Center, and Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston.
authors: Keila
authors: K
authors: Torres
authors: Pathology, University of Michigan Medical Center, Ann Arbor; and.
authors: Shannon L
authors: SL
authors: Carskadon
authors: Pathology, University of Michigan Medical Center, Ann Arbor; and.
authors: Sandra
authors: S
authors: Camelo-Piragua
authors: Pathology, University of Michigan Medical Center, Ann Arbor; and.
authors: Jonathan B
authors: JB
authors: McHugh
authors: Pathology, University of Michigan Medical Center, Ann Arbor; and.
authors: Javed
authors: J
authors: Siddiqui
authors: Pathology, University of Michigan Medical Center, Ann Arbor; and.
authors: Nallasivam
authors: N
authors: Palanisamy
authors: Pathology, University of Michigan Medical Center, Ann Arbor; and.
authors: David R
authors: DR
authors: Lucas
authors: Pathology, Sarcoma Research Center, and.
authors: Alexander J
authors: AJ
authors: Lazar
authors: Pathology.
authors: Wei-Lien
authors: WL
authors: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D008080:Liposarcoma / Q000378:metabolism* / Q000473:pathology; D050800:STAT6 Transcription Factor / Q000378:metabolism*; D012509:Sarcoma / Q000378:metabolism* / Q000473:pathology; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000378:metabolism* / Q000473:pathology; D054364:Solitary Fibrous Tumors / Q000378:metabolism* / Q000473:pathology; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human
keywords: Immunohistochemistry; STAT6; Sarcoma; Solitary fibrous tumor