title: Serum and synovial fluid nesfatin-1 concentration is associated with radiographic severity of knee osteoarthritis.
abstract: BACKGROUND
  Nesfatin-1, a member of the adipokine family, has been detected in synovial fluid (SF) from OA patients. This study aimed to determine whether there is a marked correlation of nesfatin-1 levels in serum and SF of knee OA patients with the disease severity of OA.
  
  
  METHODS
  This cross-sectional research enrolled 202 knee OA subjects. The Kellgren-Lawrence grading system was utilized to evaluate the severity of knee OA.
  
  
  RESULTS
  Elevated nesfatin-1 concentrations in serum were found in knee OA patients compared with the controls. Nesfatin-1 concentrations were markedly elevated with increased KL grades. Serum and SF nesfatin-1 concentrations were both significantly associated with the disease severity evaluated by KL grading criteria.
  
  
  CONCLUSIONS
  Our investigation indicates a marked association of serum and SF nesfatin-1 concentrations with OA disease severity.
authors: Department of Orthopedic, Xinhui People's Hospital of Southern Medical University, Jiangmen, Guangdong, China (mainland).
authors: Yusong
authors: Y
authors: Zhang
authors: Department of Endocrinology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland).
authors: Xiaolong
authors: X
authors: Shui
authors: Department of Orthopedic, Xinhui People's Hospital of Southern Medical University, Jiangmen, Guangdong, China (mainland).
authors: Xin
authors: X
authors: Lian
authors: Department of Orthopedic, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland).
authors: Gang
authors: G
authors: Wang
mesh_terms: D002135:Calcium-Binding Proteins / Q000097:blood*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D000080866:Nucleobindins; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000000981:diagnostic imaging*; D011859:Radiography; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins