title: [Prediction of epitopes of Rv1410c Mycobacterium tuberculosis protein using DNAStar software].
abstract: OBJECTIVE
  To predict the epitopes of Rv1410c Mycobacterium tuberculosis (MTB) protein.
  
  
  METHODS
  Rv1410c MTB amino acid sequence was saved and edited using Editseq software of DNAStar package, and then Protean software was used to analyze the amino acid sequence and predict the secondary structures, B cell epitopes and T cell epitopes of Rv1410c MTB. Finally, BLAST was utilized to assess its homology with human epitopes.
  
  
  RESULTS
  The Rv1410c MTB protein had abundant secondary structures. It contained a higher proportion of potential B cell epitopes located at 1-10, 67-77, 129-137, 189-205, 222-235, 253-267, 296-306, 330-338, 359-367, 462-467, 494-517 amino acid residues or nearby. Theses epitopes contained beta angle structure mostly, presenting with better antigenicity, higher surface probability and flexibility. There were also several potential T cell epitopes located at 16-37, 84-102, 108-115, 137-160, 202-207, 219-222, 245-263, 321-325, 355-362, 387-391, 417-445, 486-494 amino acid residues or nearby.
  
  
  CONCLUSIONS
  Rv1410c MTB protein contains both potential B cell antigen epitopes and potential T cell antigen epitopes.
authors: Hebei North University, Zhangjiakou 075000; PLA Key Laboratory of Tuberculosis Control and Prevention, Tuberculosis Research Institute of PLA, No. 309 Hospital of Chinese PLA, Beijing 100000, China.
authors: Jiangying
authors: J
authors: Li
authors: PLA Key Laboratory of Tuberculosis Control and Prevention, Tuberculosis Research Institute of PLA, No. 309 Hospital of Chinese PLA, Beijing 100000, China.
authors: Xuejuan
authors: X
authors: Bai
authors: PLA Key Laboratory of Tuberculosis Control and Prevention, Tuberculosis Research Institute of PLA, No. 309 Hospital of Chinese PLA, Beijing 100000, China.
authors: Yan
authors: Y
authors: Liang
authors: PLA Key Laboratory of Tuberculosis Control and Prevention, Tuberculosis Research Institute of PLA, No. 309 Hospital of Chinese PLA, Beijing 100000, China.
authors: Junxian
authors: J
authors: Zhang
authors: PLA Key Laboratory of Tuberculosis Control and Prevention, Tuberculosis Research Institute of PLA, No. 309 Hospital of Chinese PLA, Beijing 100000, China.
authors: Yourong
authors: Y
authors: Yang
authors: Hebei North University, Zhangjiakou 075000; PLA Key Laboratory of Tuberculosis Control and Prevention, Tuberculosis Research Institute of PLA, No. 309 Hospital of Chinese PLA, Beijing 100000, China.
authors: Weiguo
authors: W
authors: Zhao
authors: PLA Key Laboratory of Tuberculosis Control and Prevention, Tuberculosis Research Institute of PLA, No. 309 Hospital of Chinese PLA, Beijing 100000, China.
authors: Xueqiong
authors: X
authors: Wu
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000276:immunology*; D000939:Epitopes / Q000737:chemistry* / Q000235:genetics / Q000276:immunology*; D018985:Epitopes, B-Lymphocyte / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D026901:Membrane Transport Proteins / Q000737:chemistry* / Q000235:genetics / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D012984:Software; D014376:Tuberculosis / Q000382:microbiology*
chemical_list: D001426:Bacterial Proteins; D000939:Epitopes; D018985:Epitopes, B-Lymphocyte; D026901:Membrane Transport Proteins; C425143:P55 protein, Mycobacterium