title: Controlling epileptiform activity with organic electronic ion pumps.
abstract: In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.
authors: Aix Marseille Université, INS, UMR_S 1106, 13005, Marseille, France.|Inserm, UMR_S 1106, 13005, Marseille, France.
authors: Adam
authors: A
authors: Williamson
authors: Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, France.
authors: Jonathan
authors: J
authors: Rivnay
authors: Laboratory of Organic Electronics, Department of Science and Technology Linköping University, 601 74, Norrköping, Sweden.
authors: Loïg
authors: L
authors: Kergoat
authors: Laboratory of Organic Electronics, Department of Science and Technology Linköping University, 601 74, Norrköping, Sweden.
authors: Amanda
authors: A
authors: Jonsson
authors: Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, France.
authors: Sahika
authors: S
authors: Inal
authors: Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, France.
authors: Ilke
authors: I
authors: Uguz
authors: Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, France.
authors: Marc
authors: M
authors: Ferro
authors: Aix Marseille Université, INS, UMR_S 1106, 13005, Marseille, France.|Inserm, UMR_S 1106, 13005, Marseille, France.
authors: Anton
authors: A
authors: Ivanov
authors: Laboratory of Organic Electronics, Department of Science and Technology Linköping University, 601 74, Norrköping, Sweden.
authors: Theresia Arbring
authors: TA
authors: Sjöström
authors: Laboratory of Organic Electronics, Department of Science and Technology Linköping University, 601 74, Norrköping, Sweden.
authors: Daniel T
authors: DT
authors: Simon
authors: Laboratory of Organic Electronics, Department of Science and Technology Linköping University, 601 74, Norrköping, Sweden.
authors: Magnus
authors: M
authors: Berggren
authors: Department of Bioelectronics, Ecole Nationale Supérieure des Mines, CMP-EMSE, MOC, 13541, Gardanne, France.
authors: George G
authors: GG
authors: Malliaras
authors: Aix Marseille Université, INS, UMR_S 1106, 13005, Marseille, France.|Inserm, UMR_S 1106, 13005, Marseille, France.
authors: Christophe
authors: C
authors: Bernard
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000503:physiopathology*; D056654:CA3 Region, Hippocampal / Q000187:drug effects / Q000503:physiopathology*; D002704:Chlorates / Q000378:metabolism; D055615:Electrical Equipment and Supplies; D004583:Electrons; D004827:Epilepsy / Q000503:physiopathology* / Q000628:therapy*; D004867:Equipment Design; D007477:Ions / Q000008:administration & dosage; D008274:Magnesium / Q000378:metabolism; D051379:Mice; D017966:Pyramidal Cells / Q000187:drug effects / Q000502:physiology; D046509:Tissue Culture Techniques; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage
chemical_list: D000927:Anticonvulsants; D002704:Chlorates; D007477:Ions; D005680:gamma-Aminobutyric Acid; D008274:Magnesium; C022842:chloric acid
keywords: PEDOT:PSS; neuroengineering; organic bioelectronics; organic electronic ion pumps