title: Impact of high lipoprotein(a) levels on in-stent restenosis and long-term clinical outcomes of angina pectoris patients undergoing percutaneous coronary intervention with drug-eluting stents in Asian population.
abstract: Lipoprotein(a) (Lp(a)) is known to be associated with cardiovascular complications and atherothrombotic properties in general populations. However, it has not been examined whether Lp(a) levels are able to predict adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). A total of 595 consecutive patients with angina pectoris who underwent elective PCI with DES were enrolled from 2004 to 2010. The patients were divided into two groups according to the levels of Lp(a): Lp(a) < 50 mg/dL (n = 485 patients), and Lp(a) ≥ 50 mg/dL (n = 111 patients). The 6-9-month angiographic outcomes and 3-year cumulative major clinical outcomes were compared between the two groups. Binary restenosis occurred in 26 of 133 lesions (19.8%) in the high Lp(a) group and 43 of 550 lesions (7.9%) in the low Lp(a) group (P = 0.001). In multivariate analysis, the reference vessel diameter, low density lipoprotein cholesterol, total lesion length, and Lp(a) ≥ 50 mg/dL were predictors of binary restenosis. In the Cox proportional hazards regression analysis, Lp(a) > 50 mg/dL was significantly associated with the 3-year adverse clinical outcomes including any myocardial infarction, revascularization (target lesion revascularization (TLR) and target vessel revascularization (TVR)), TLR-major adverse cardiac events (MACEs), TVR-MACE, and All-MACEs. In our study, high Lp(a) level ≥ 50 mg/dL in angina pectoris patients undergoing elective PCI with DES was significantly associated with binary restenosis and 3-year adverse clinical outcomes in an Asian population.
authors: Division of Cardiology, Department of Internal Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan, Korea.
authors: Sang-Ho
authors: SH
authors: Park
authors: Cardiovascular Center, Korea University, Guro Hospital, Seoul, Korea.
authors: Seung-Woon
authors: SW
authors: Rha
authors: Cardiovascular Center, Korea University, Guro Hospital, Seoul, Korea.
authors: Byoung-Geol
authors: BG
authors: Choi
authors: Division of Cardiology, Department of Internal Medicine, Eulji Medical University, Seoul, Korea.
authors: Ji-Young
authors: JY
authors: Park
authors: Division of Cardiology, Department of Internal Medicine, Soonchunhyang University, Cheonan Hospital, Cheonan, Korea.
authors: Ung
authors: U
authors: Jeon
authors: Cardiovascular Center, Korea University, Guro Hospital, Seoul, Korea.
authors: Hong-Seog
authors: HS
authors: Seo
authors: Cardiovascular Center, Korea University, Guro Hospital, Seoul, Korea.
authors: Eung-Ju
authors: EJ
authors: Kim
authors: Cardiovascular Center, Korea University, Guro Hospital, Seoul, Korea.
authors: Jin-Oh
authors: JO
authors: Na
authors: Cardiovascular Center, Korea University, Guro Hospital, Seoul, Korea.
authors: Cheol-Ung
authors: CU
authors: Choi
authors: Cardiovascular Center, Korea University, Guro Hospital, Seoul, Korea.
authors: Jin-Won
authors: JW
authors: Kim
authors: Cardiovascular Center, Korea University, Guro Hospital, Seoul, Korea.
authors: Hong-Euy
authors: HE
authors: Lim
authors: Cardiovascular Center, Korea University, Guro Hospital, Seoul, Korea.
authors: Chang-Gyu
authors: CG
authors: Park
authors: Cardiovascular Center, Korea University, Guro Hospital, Seoul, Korea.
authors: Dong-Joo
authors: DJ
authors: Oh
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology; D044466:Asian People / Q000208:ethnology; D015415:Biomarkers / Q000097:blood; D023903:Coronary Restenosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000208:ethnology; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011159:Population Surveillance; D011446:Prospective Studies; D011859:Radiography; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D017270:Lipoprotein(a)
keywords: angina; coronary; lipoprotein(a); restenosis; stents