title: [Clinicoelectrophysiological characteristics of peripheral nerves with paraproteinemia].
abstract: OBJECTIVE
  To explore the clinicoelectrophysiological characteristics of paraproteinemic neuropathy (PPN).
  
  
  METHODS
  Retrospective analyses were performed for the clinical data, including clinical characteristics, laboratory and neural electrophysiological examinations, of hospitalized patients with definitively diagnosed PPN from 2008 to 2012. Their objective parameters were compared between different sub-groups.
  
  
  RESULTS
  There were 12 males and 8 females with an average age of 52 years. The average clinical course was 14 (2-36) months. The types were IgM monoclonal gammopathy (MG) (n = 2, 10%), IgG MG (n = 10, 50%), IgA MG (n = 7, 35%) and λ light chain MG (n = 1, 5%). This cohort had predominant sensory and axonal polyneuropathy with distal involvement. And the subtype of IgA and IgG manifested predominant sensory and axonal polyneuropathy.
  
  
  CONCLUSIONS
  The PPN patients have predominant sensory, axonal and distal symmetric polyneuropathy with clinical heterogeneities. PPN must be suspected even if sensory impairment and demyelination are not the dominant features. For patients with peripheral neuropathy, typing of monoclonal immunoglobulins should be routinely performed.
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
authors: Hefei
authors: H
authors: Tang
authors: Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China. Email: ttyy0142011@126.com.
authors: Zaiqiang
authors: Z
authors: Zhang
mesh_terms: D001369:Axons; D055724:Electrophysiological Phenomena; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias; D010525:Peripheral Nerves; D011115:Polyneuropathies; D012189:Retrospective Studies
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M