title: Maternal inheritance of severe hypertriglyceridemia impairs glucose metabolism in offspring.
abstract: Maternally inherited familial hypercholesterolemia (FH) impairs glucose metabolism and increases cardiovascular risks in the offspring to a greater degree than paternal inherited FH. However, it remains unknown whether hypertriglyceridemia affects glucose metabolism via inheritance. In this study, we sought to compare the impact of maternally and paternally inherited hypertriglyceridemia on glucose and lipid metabolism in mice. ApoCIII transgenic mice with severe hypertriglyceridemia were mated with non-transgenic control mice to obtain 4 types of offspring: maternal non-transgenic control and maternal transgenic offspring, and paternal control and paternal transgenic offspring. Plasma triglycerides (TG), total cholesterol (TC), fasting plasma glucose (FPG) and fasting insulin (FINS) were measured. ApoCIII overexpression caused severe hypertriglyceridemia, but the transgenic female mice had unaltered fertility with normal pregnancy and birth of pups. The 4 groups of offspring had similar birth weight and growth rate. The plasma TG of maternal and paternal transgenic offspring were nearly 40-fold higher than maternal and paternal control mice, but there was no difference in plasma TG between maternal and paternal transgenic offspring. Although the FPG of the 4 groups of animals had no difference, the maternal transgenic mice showed impaired glucose tolerance, increased FINS levels and higher homeostasis model assessment insulin resistance index (HOMA-IR) than the other 3 groups. In conclusion, maternally inherited hypertriglyceridemia in ApoCIII transgenic mice displayed impaired glucose tolerance, hyperinsulinemia and increased HOMA-R, while paternally inherited hypertriglyceridemia did not have such impacts.
authors: Department of Endocrinology, Beijing Puren Hospital, Beijing, China;
authors: Ya-Hong
authors: YH
authors: Ma
authors: Institute of Cardiovascular Sciences, Peking University and Key Laboratory of Cardiovascular Sciences, Administration of Education, Beijing, China; ; Department of Endocrinology, Luhe Teaching Hospital of Capital Medical University, Beijing;
authors: Caiguo
authors: C
authors: Yu
authors: Institute of Cardiovascular Sciences, Peking University and Key Laboratory of Cardiovascular Sciences, Administration of Education, Beijing, China;
authors: Abudurexiti
authors: A
authors: Kayoumu
authors: Institute of Cardiovascular Sciences, Peking University and Key Laboratory of Cardiovascular Sciences, Administration of Education, Beijing, China;
authors: Xin
authors: X
authors: Guo
authors: Department of General Surgery, Luhe Teaching Hospital of Capital Medical University, Beijing.
authors: Zhili
authors: Z
authors: Ji
authors: Institute of Cardiovascular Sciences, Peking University and Key Laboratory of Cardiovascular Sciences, Administration of Education, Beijing, China;
authors: George
authors: G
authors: Liu
keywords: Apolipoprotein CIII; Hypertriglyceidemia; Insulin resistance; Transgenic mice