title: Genetic influence on left ventricular structure and function: a Korean twin and family study.
abstract: Genetic factors have been suggested to be one of the determinants of the variation of left ventricular (LV) structure and function. However, the heritability range of LV structure varies across studies and the influence of genetics on LV function is not well established, especially in Asian populations. Study subjects were 1,642 healthy Korean adults from 426 families, consisting of 298 pairs of monozygotic twins, 62 pairs of dizygotic twins, one set of triplets, 567 siblings, and 354 parents. LV structure and function were measured by M-mode and 2D echocardiography, and conventional and tissue Doppler imaging (TDI). Pairwise intra-class correlations for various familial relationships and heritability were estimated for LV structure and function. The heritability of LV mass, LV ejection fraction (LVEF), left atrial volume index, the ratio between early and late diastolic velocity of mitral inflow (E/A ratio), and the ratio between early diastolic velocity of mitral inflow and early diastolic mitral annular velocities (E/Ea ratio) was 0.44, 0.27, 0.44, 0.25, and 0.33, respectively. Bivariate genetic analysis showed that LV structural and functional traits had significant genetic correlations with cardiovascular risk factors. Additive genetic correlation (ρG) of LV mass with body mass index, systolic blood pressure, and high density lipoprotein cholesterol were 0.49, 0.42, and -0.15 respectively. LVEF (ρG = 0.33) and left atrial volume index (ρG = 0.24) also had a significant genetic correlation with systolic blood pressure. These findings support the theory that genetic factors have significant influence on these traits and necessitate further work to identify the specific genes involved.
authors: Department of Family Medicine,Hallym Sacred Heart Hospital,College of Medicine,Hallym University,Anyang,South Korea.
authors: Hye-Mi
authors: HM
authors: Noh
authors: Department of Cardiology and Cardiovascular Imaging Center,Cardiac and Vascular Center,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul,South Korea.
authors: Sang Cheol
authors: SC
authors: Lee
authors: Department of Cardiology and Cardiovascular Imaging Center,Cardiac and Vascular Center,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul,South Korea.
authors: Seung Woo
authors: SW
authors: Park
authors: Department of Epidemiology,School of Public Health,Seoul National University.
authors: Joohon
authors: J
authors: Sung
authors: Department of Family Medicine,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul,South Korea.
authors: Yun-Mi
authors: YM
authors: Song
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000235:genetics; D001786:Blood Glucose / Q000032:analysis / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D004200:Diseases in Twins / Q000453:epidemiology; D059647:Gene-Environment Interaction; D006325:Heart Atria / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000502:physiology; D009929:Organ Size / Q000235:genetics; D010290:Parents; D019655:Quantitative Trait, Heritable; D012016:Reference Values; D056910:Republic of Korea; D012307:Risk Factors; D035781:Siblings; D014429:Twins, Dizygotic / Q000706:statistics & numerical data; D014430:Twins, Monozygotic / Q000706:statistics & numerical data; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000235:genetics* / Q000502:physiology
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL
keywords: Korean; echocardiography; genetics; heart ventricles; twin study