title: Superbugs causing ventilator associated pneumonia in a tertiary care hospital and the return of pre-antibiotic era!
abstract: The rise in super bugs causing Ventilator-Associated Pneumonia (VAP) is a major cause of mortality and morbidity despite recent advances in management owing to the looming 'antibiotic apocalypse'. The aetiology and susceptibility pattern of the VAP isolates varies with patient population, type of intensive care unit (ICU) and is an urgent diagnostic challenge. The present study carried out for a period of one year in a tertiary care hospital, enrolled patients on mechanical ventilation (MV) for ≥48 hrs. Endotracheal aspirates (ETA) from suspected VAP patients were processed by semi quantitative method. Staphylococus aureus, members of Enterobacteriaceae were more common in early onset VAP (EOVAP), while Nonfermenting Gram negative bacilli (NFGNB) were significantly associated with late onset VAP (LOVAP). Most of the isolates were multi drug resistant (MDR) super bugs. With limited treatment options left for this crisis situation like the pre-antibiotic era; it is an alarm for rational antibiotic therapy usage and intensive education programs.
authors: S
authors: S
authors: Qureshi
authors: Department of Microbiology, Subharti Medical College, Delhi-Haridwar Bypass, Meerut - 250 005, Uttar Pradesh, India.
authors: C
authors: C
authors: Agrawal
authors: M
authors: M
authors: Madan
authors: A
authors: A
authors: Pandey
authors: H
authors: H
authors: Chauhan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000382:microbiology*; D053717:Pneumonia, Ventilator-Associated / Q000382:microbiology*; D011446:Prospective Studies; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D062606:Tertiary Care Centers; D014132:Trachea / Q000382:microbiology; D055815:Young Adult