title: Lack of genetic association of 5-HTR2A 102 T/C and -1438A/G polymorphisms with Tourette syndrome in a family-based association study in a Chinese Han population.
abstract: BACKGROUND
  Our purpose is to investigate whether polymorphisms of 102 T/C and -1438A/G in 5HTR2A are associated with Tourette syndrome (TS) in Chinese Han population.
  
  
  METHODS
  A total of 178 TS trios were recruited in this study. After the allelic and genotypic distributions of two polymorphisms were genotyped using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP), we compared their genetic distributions with what is expected with Hardy-Weinberg to explore whether there might be an association of these polymorphisms with TS by haplotype relative risk (HRR) and transmission disequilibrium test (TDT) statistics.
  
  
  RESULTS
  Our results showed that no significant associations were found between the HTR2A 102 T/C and -1438A/G polymorphisms and TS (for HTR2A 102 T/C: TDT = 2.041, df = 1, P = 0.175; HRR = 1.468, χ(2)  = 1.905, P = 0.168, 95% confidence interval: 0.850-2.535; for HTR2A: -1438A/G, TDT = 0.093, df = 1, P = 0.819; HRR = 0.965, χ(2)  = 0.018, P = 0.894, 95% confidence interval: 0.574-1.624).
  
  
  CONCLUSIONS
  Our study suggested that the HTR2A 102T/C and -1438A/G polymorphisms may not be associated with susceptibility to TS, and thus do not play a major role in the development of TS in the Chinese Han population. However, these results need to be confirmed in a larger sample collected from different populations.
authors: Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Longqiang
authors: L
authors: Xu
authors: Department of Psychiatry, Medical College, Qingdao University, Qingdao, China.
authors: Lanlan
authors: L
authors: Zheng
authors: Reproductive Medicine Centre, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Jianhua
authors: J
authors: Ma
authors: Department of Clinical Laboratory, Qingdao Women & Children Medical Healthcare Center, Qingdao, China.
authors: Nailun
authors: N
authors: Su
authors: The Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Yujun
authors: Y
authors: Liu
authors: Graduate School, Peking Union Medical College, Beijing, China.|National Research Institute for Family Planning, Beijing, China.|World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China.
authors: Xu
authors: X
authors: Ma
authors: Department of Psychiatry, Medical College, Qingdao University, Qingdao, China.
authors: Xinhua
authors: X
authors: Zhang
authors: Genetic Laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.|Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
authors: Shiguo
authors: S
authors: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics* / Q000523:psychology; D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000523:psychology; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D005879:Tourette Syndrome / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A
keywords: HRR; HTR2A -1438A/G; HTR2A102 T/C; TDT; Tourette syndrome