title: New Look at BTEX: Are Ambient Levels a Problem?
abstract: Benzene, toluene, ethylbenzene, and xylene (BTEX) are retrieved during fossil fuel extraction and used as solvents in consumer and industrial products, as gasoline additives, and as intermediates in the synthesis of organic compounds for many consumer products. Emissions from the combustion of gasoline and diesel fuels are the largest contributors to atmospheric BTEX concentrations. However, levels indoors (where people spend greater than 83% of their time) can be many times greater than outdoors. In this review we identified epidemiological studies assessing the noncancer health impacts of ambient level BTEX exposure (i.e., nonoccupational) and discussed how the health conditions may be hormonally mediated. Health effects significantly associated with ambient level exposure included sperm abnormalities, reduced fetal growth, cardiovascular disease, respiratory dysfunction, asthma, sensitization to common antigens, and more. Several hormones including estrogens, androgens, glucocorticoids, insulin, and serotonin may be involved in these health outcomes. This analysis suggests that all four chemicals may have endocrine disrupting properties at exposure levels below reference concentrations (i.e., safe levels) issued by the U.S. Environmental Protection Agency. These data should be considered when evaluating the use of BTEX in consumer and industrial products and indicates a need to change how chemicals present at low concentrations are assessed and regulated.
authors: †The Endocrine Disruption Exchange (TEDX), Paonia, Colorado 81428, United States.
authors: Ashley L
authors: AL
authors: Bolden
authors: †The Endocrine Disruption Exchange (TEDX), Paonia, Colorado 81428, United States.|‡Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado 80309, United States.
authors: Carol F
authors: CF
authors: Kwiatkowski
authors: †The Endocrine Disruption Exchange (TEDX), Paonia, Colorado 81428, United States.
authors: Theo
authors: T
authors: Colborn
mesh_terms: D001554:Benzene / Q000633:toxicity; D001555:Benzene Derivatives / Q000633:toxicity*; D004781:Environmental Exposure; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D014050:Toluene / Q000633:toxicity; D014992:Xylenes / Q000633:toxicity
chemical_list: D001555:Benzene Derivatives; D004785:Environmental Pollutants; D014992:Xylenes; D014050:Toluene; D001554:Benzene; C004912:ethylbenzene