title: Long-Term Outcome of Implant Rehabilitations in Patients with Systemic Disorders and Smoking Habits: A Retrospective Clinical Study.
abstract: BACKGROUND
  There is a need for more studies investigating the outcome of implant-supported rehabilitations in patients with systemic disorders.
  
  
  METHODS
  This retrospective clinical study included 721 patients with systemic disorders or smoking habits (422 females; 299 males), with an average age of 51 years, rehabilitated with 3,998 implants and followed for 3-17 years (average 8 years). Outcome measures were: implant survival rates calculated based on implant function through life tables and using the patient (first implant failure censored) and implant as units of analysis; marginal bone levels measured at 1, 5, and 10 years; and the incidence of biological complications (peri-implant pathology, abscess formation, fistula formation, and suppuration).
  
  
  RESULTS
  Eighty-seven patients were lost to follow-up (12%). Forty-five patients experienced prosthetic failure rendering a 94.3% survival rate. One hundred seventy-three implants failed in 98 patients, rendering an 83.5% (patient level) and 94.6% (implant level) cumulative survival rate. The average marginal bone levels were 1.18 mm, 1.56 mm, and 1.47 mm at 1, 5, and 10 years, respectively. Biological complications occurred in 86 patients (11.9%).
  
  
  CONCLUSIONS
  Implant rehabilitations in patients presenting systemic disorders or smoking habits are possible with good outcomes. Nevertheless, different impacts on implant rehabilitations were registered according to the type of systemic disorder.
authors: Oral Surgery Department, Malo Clinic, Lisbon, Portugal.
authors: Paulo
authors: P
authors: Maló
authors: Research and Development Department, Malo Clinic, Lisbon, Portugal.
authors: Miguel
authors: M
authors: de Araújo Nobre
authors: Oral Hygiene Department, Malo Clinic, Lisbon, Portugal.
authors: Yolande
authors: Y
authors: Gonçalves
authors: Oral Surgery Department, Malo Clinic, Lisbon, Portugal.
authors: Armando
authors: A
authors: Lopes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016301:Alveolar Bone Loss; D015897:Comorbidity; D019094:Dental Prosthesis, Implant-Supported; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D012189:Retrospective Studies; D012907:Smoking
keywords: cardiovascular; clinical research; diabetes; fixed implant prosthesis; implant; implant surface; marginal bone loss; osseointegration