title: Ticagrelor-induced renal failure leading to statin-induced rhabdomyolysis.
abstract: Renal function deterioration is a rather frequent side effect of ticagrelor; this is especially so in patients over the age of 75, with pre-existent mild renal failure and/or taking an angiotensin receptor inhibitor. We describe a patient in whom deterioration of renal function due to ticagrelor led to a rise in serum concentration of rosuvastatin which resulted in rhabdomyolysis. The presented case emphasises the importance to check renal function routinely before and one month after starting ticagrelor and to screen carefully for possible interactions with other drugs.
authors: Gelre Hospitals, Apeldoorn, the Netherlands.
authors: A J
authors: AJ
authors: van Vuren
authors: B
authors: B
authors: de Jong
authors: H P R
authors: HP
authors: Bootsma
authors: M J
authors: MJ
authors: Van der Veen
authors: G W
authors: GW
authors: Feith
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000241:Adenosine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000368:Aged; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D008297:Male; D012206:Rhabdomyolysis / Q000209:etiology*; D000068718:Rosuvastatin Calcium / Q000009:adverse effects; D000077486:Ticagrelor
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000068718:Rosuvastatin Calcium; D000077486:Ticagrelor; D000241:Adenosine