title: Evaluation of anti-inflammatory, analgesic and antipyretic activities of Thymus serphyllum Linn. in mice.
abstract: The present study was conducted to evaluate the analgesic, anti-inflammatory and antipyretic activities of Thymus serphyllum Linn. in mice. Anti-inflammatory activity was evaluated by carrageenan and egg albumin induced paw edema in mice, while analgesic activity was assessed using formalin induced paw licking and acetic acid induced abdominal writhing in mice. For determination of antipyretic activity, pyrexia was induced by subcutaneous injection of 20% yeast. All the extracts produced significant anti-inflammatory effect however, ether extract produced maximum effect 34% inhibition (p < 0.001) against carrageenan and 22% (p < 0.01) inhibition against egg albumin induced paw edema in mice at the end of 3 h. Ether extract produced prominent analgesic effect 77% (p < 0.001) inhibition in acetic acid induced abdominal writhing and 59% inhibition in formalin induced paw licking model in mice, respectively. Ether extract also demonstrated significant (p < 0.001) antipyretic activity against yeast induced pyrexia. The plant showed no sign of toxicity up to the dose of 2000 mg/kg in mice. This study supports the use of Thymus serphyllum in traditional medicine for inflammation accompanied by pain and fever.
authors: Alamger
authors: Uzma
authors: U
authors: Mazhar
authors: Muhammad Naveed
authors: MN
authors: Mushtaq
authors: Hafeez Ullah
authors: HU
authors: Khan
authors: Safirah
authors: S
authors: Maheen
authors: Muhammad Nasir Hayat
authors: MN
authors: Malik
authors: Taseer
authors: T
authors: Ahmad
authors: Fouzia
authors: F
authors: Latif
authors: Nazia
authors: N
authors: Tabassum
authors: Abdul Qayyum
authors: AQ
authors: Khan
authors: Haseeb
authors: H
authors: Ahsan
authors: Wasim
authors: W
authors: Khan
authors: Ibrahim
authors: I
authors: Javed
authors: Haider
authors: H
authors: Ali
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D058633:Antipyretics / Q000494:pharmacology*; D005260:Female; D005334:Fever / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology*; D046930:Thymus Plant / Q000737:chemistry*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D010936:Plant Extracts