title: Rapid, sensitive, and selective fluorescent DNA detection using iron-based metal-organic framework nanorods: Synergies of the metal center and organic linker.
abstract: Considerable recent attention has been paid to homogeneous fluorescent DNA detection with the use of nanostructures as a universal "quencher", but it still remains a great challenge to develop such nanosensor with the benefits of low cost, high speed, sensitivity, and selectivity. In this work, we report the use of iron-based metal-organic framework nanorods as a high-efficient sensing platform for fluorescent DNA detection. It only takes about 4 min to complete the whole "mix-and-detect" process with a low detection limit of 10 pM and a strong discrimination of single point mutation. Control experiments reveal the remarkable sensing behavior is a consequence of the synergies of the metal center and organic linker. This work elucidates how composition control of nanostructures can significantly impact their sensing properties, enabling new opportunities for the rational design of functional materials for analytical applications.
authors: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
authors: Jingqi
authors: J
authors: Tian
authors: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China.
authors: Qian
authors: Q
authors: Liu
authors: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China; Optical Engineering Key Laboratory of Chongqing Municipal Education Commission, College of Physics and Information Technology, Chongqing Normal University, Chongqing 40047, China.
authors: Jinle
authors: J
authors: Shi
authors: Optical Engineering Key Laboratory of Chongqing Municipal Education Commission, College of Physics and Information Technology, Chongqing Normal University, Chongqing 40047, China.
authors: Jianming
authors: J
authors: Hu
authors: Chemistry Department and Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
authors: Abdullah M
authors: AM
authors: Asiri
authors: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China. Electronic address: sunxp@ciac.ac.cn.
authors: Xuping
authors: X
authors: Sun
authors: Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130033, China. Electronic address: yuquanhe@hotmail.com.
authors: Yuquan
authors: Y
authors: He
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D043942:Nanotubes / Q000648:ultrastructure; D009942:Organometallic Compounds / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D009942:Organometallic Compounds; D004247:DNA; D007501:Iron
keywords: DNA; Fluorescent sensing; Iron-based metal–organic framework; Nanorod; Synergies