title: Serological investigation of heartland virus (Bunyaviridae: Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013.
abstract: Heartland virus (HRTV; Bunyaviridae: Phlebovirus) has recently emerged as a causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States. The lone star tick (Amblyomma americanum L.) has been implicated as a vector. To identify candidate vertebrate amplification hosts associated with enzootic maintenance of the virus, sera and ticks were sampled from 160 mammals (8 species) and 139 birds (26 species) captured near 2 human case residences in Andrew and Nodaway Counties in northwest Missouri. HRTV-specific neutralizing antibodies were identified in northern raccoons (42.6%), horses (17.4%), white-tailed deer (14.3%), dogs (7.7%), and Virginia opossums (3.8%), but not in birds. Virus isolation attempts from sera and ticks failed to detect HRTV. The high antibody prevalence coupled with local abundance of white-tailed deer and raccoons identifies these species as candidate amplification hosts.
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Angela M
authors: AM
authors: Bosco-Lauth
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Nicholas A
authors: NA
authors: Panella
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: J Jeffrey
authors: JJ
authors: Root
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Tom
authors: T
authors: Gidlewski
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: R Ryan
authors: RR
authors: Lash
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Jessica R
authors: JR
authors: Harmon
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Kristen L
authors: KL
authors: Burkhalter
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Marvin S
authors: MS
authors: Godsey
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Harry M
authors: HM
authors: Savage
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: William L
authors: WL
authors: Nicholson
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
authors: Nicholas
authors: N
authors: Komar
authors: Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia abrault@cdc.gov.
authors: Aaron C
authors: AC
authors: Brault
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000821:virology*; D000835:Animals, Wild / Q000821:virology*; D001717:Birds / Q000821:virology; D002044:Bunyaviridae Infections / Q000453:epidemiology* / Q000662:veterinary / Q000821:virology; D003670:Deer / Q000821:virology; D048293:Didelphis / Q000821:virology; D004199:Disease Vectors; D006736:Horses / Q000821:virology; D006801:Humans; D008923:Missouri / Q000453:epidemiology; D009500:Neutralization Tests; D016856:Phlebovirus; D011821:Raccoons / Q000821:virology; D013987:Ticks / Q000821:virology; D015047:Zoonoses / Q000453:epidemiology / Q000821:virology