title: S100A12 and RAGE expression in human bladder transitional cell carcinoma: a role for the ligand/RAGE axis in tumor progression?
abstract: BACKGROUND
  Transitional cell carcinoma (TCC) and prostate cancer are the most frequent cancers in the male genitourinary tract. Measurement of biological biomarkers may facilitate clinical monitoring and aid early diagnosis of TCC. The aim of the present investigation was to detect the mRNA levels of S100A12 and RAGE (receptor for advanced glycation end products) in patients suffering from bladder TCC.
  
  
  METHODS
  To explore the involvement of S100A12 and RAGE genes, total RNA was harvested from cancer tissues and samples obtained from normal non-tumorized urothelium of the same patients. Quantitative PCR (qPCR) was subsequently employed to determine the mRNA levels of S100A12 and RAGE.
  
  
  RESULTS
  The results showed that mRNA expression of S100A12 and RAGE was significantly up-regulated in the cancer tissue.
  
  
  CONCLUSIONS
  According to the results presented in the current study, mRNA expression of S100A12 and RAGE might be as a useful biomarker for TCC. Therefore, this ligand-receptor axis possibly plays important roles in the development of TCC and may serve either as an early diagnostic marker or as a key factor in monitoring of response to treatment. More research is required concerning inhibition of the S100A12-RAGE axis in different cancer models.
authors: Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran E-mail : abedinoro@yahoo.com.
authors: Hossein
authors: H
authors: Khorramdelazad
authors: Vahid
authors: V
authors: Bagheri
authors: Gholamhossein
authors: G
authors: Hassanshahi
authors: Hormoz
authors: H
authors: Karami
authors: Mozhgan
authors: M
authors: Moogooei
authors: Masoud
authors: M
authors: Zeinali
authors: Mehdi
authors: M
authors: Abedinzadeh
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D002295:Carcinoma, Transitional Cell / Q000235:genetics* / Q000473:pathology; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D000067759:Receptor for Advanced Glycation End Products / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000067616:S100A12 Protein / Q000235:genetics*; D001743:Urinary Bladder / Q000378:metabolism* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D000067759:Receptor for Advanced Glycation End Products; D000067616:S100A12 Protein; C090441:S100A12 protein, human