title: Polymorphous low-grade adenocarcinoma of the head and neck: A population-based study of 460 cases.
abstract: OBJECTIVE
  Polymorphous low-grade adenocarcinoma (PLGA) is a rare malignant neoplasm of the minor salivary glands. This study analyzes the demographic, clinicopathologic, incidence, and survival characteristics of head and neck PLGA (HN-PLGA).
  
  
  METHODS
  The Surveillance, Epidemiology, and End Results (SEER) database was queried for HN-PLGA cases from 2001 to 2011 (460 cases). Data analyzed included patient demographics, incidence trends, and survival outcomes.
  
  
  RESULTS
  Head and neck PLGA occurred most frequently in the sixth and seventh decades of life. Mean age at diagnosis was 61.3 (± 15.0) years. There was a female predilection with a female-to-male ratio of 2.15:1. There was a predilection toward blacks among the US population, with black-to-white incidence rate ratio of 2.33:1. The most common site of HN-PLGA was the palate (57.2%), followed by the lip (7.0%). Average tumor size was 2.1 (± 1.3) cm at presentation. The majority of cases were localized at the time of presentation (70.5%), with rare distant metastasis (4.3%). The most common treatment modality was surgery alone (77.9%), followed by surgery with radiotherapy (19.5%). Elective neck dissection was performed in 5.3% of the cases. Survival analysis showed excellent 10-year disease-specific (96.4%) and relative (94.7%) survival rates. Ten-year disease-specific survival was better among those treated with surgery alone (98.0%) or surgery with adjuvant radiotherapy (90.9%) than those treated with radiotherapy alone (75.0%) (P < 0.0001).
  
  
  CONCLUSIONS
  This study represents the largest cohort of HN-PLGA cases. Head and neck PLGA shows a predilection for women and blacks in the US population. It has an excellent survival outcome with surgery being the treatment of choice.
authors: Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey.
authors: Tapan D
authors: TD
authors: Patel
authors: Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey.
authors: Alejandro
authors: A
authors: Vazquez
authors: Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey.
authors: Emily
authors: E
authors: Marchiano
authors: Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey.
authors: Richard Chan
authors: RC
authors: Park
authors: Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey.|Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey.
authors: Soly
authors: S
authors: Baredes
authors: Department of Otolaryngology-Head and Neck Surgery, Neurological Institute of New Jersey.|Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey.|Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, U.S.A.
authors: Jean Anderson
authors: JA
authors: Eloy
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011159:Population Surveillance / Q000379:methods*; D011379:Prognosis; D018426:SEER Program; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology
keywords: Polymorphous low-grade adenocarcinoma; SEER; demographic; disease-specific survival; incidence; malignancy; minor salivary glands; palate; relative survival