title: A dynamic model of chemoattractant-induced cell migration.
abstract: Cell migration refers to a directional cell movement in response to chemoattractant stimulation. In this work, we developed a cell-migration model by mimicking in vivo migration using optically manipulated chemoattractant-loaded microsources. The model facilitates a quantitative characterization of the relationship among the protrusion force, cell motility, and chemoattractant gradient for the first time (to our knowledge). We verified the correctness of the model using migrating leukemia cancer Jurkat cells. The results show that one can achieve the ideal migrating capacity by choosing the appropriate chemoattractant gradient and concentration at the leading edge of the cell.
authors: Department of Automation, University of Science and Technology of China, Hefei, China; Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
authors: Hao
authors: H
authors: Yang
authors: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
authors: Xue
authors: X
authors: Gou
authors: Department of Automation, University of Science and Technology of China, Hefei, China.
authors: Yong
authors: Y
authors: Wang
authors: Department of Biomedical Engineering, Yale University, New Haven, Connecticut.
authors: Tarek M
authors: TM
authors: Fahmy
authors: Department of Medicine, The University of Hong Kong, Hong Kong, China.
authors: Anskar Y-H
authors: AY
authors: Leung
authors: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China.
authors: Jian
authors: J
authors: Lu
authors: Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong, China. Electronic address: medsun@cityu.edu.hk.
authors: Dong
authors: D
authors: Sun
mesh_terms: D002465:Cell Movement / Q000187:drug effects*; D002630:Chemotactic Factors / Q000494:pharmacology*; D006801:Humans; D019169:Jurkat Cells; D008954:Models, Biological; D052898:Optical Tweezers
chemical_list: D002630:Chemotactic Factors