title: [6]-gingerol induces electrogenic sodium absorption in the rat colon via the capsaicin receptor TRPV1.
abstract: [6]-Gingerol possesses a variety of beneficial pharmacological and therapeutic properties, including anti-carcinogenic, anti-inflammatory, and anti-emetic activities. Although [6]-gingerol is known to regulate the contraction of the intestine, its effect on intestinal ion transport is unclear. The aim of this study was to examine the role of [6]-gingerol in the regulation of electrogenic ion transport in the rat intestine by measuring the transmural potential difference (ΔPD). [6]-Gingerol induced significant positive ΔPD when administered to the serosal but not mucosal side of the colon, ileum, and jejunum; the highest effect was detected in the colon at a concentration of 10 μM. [6]-Gingerol-induced increase in ΔPD was suppressed by ouabain, an inhibitor of Na(+)/K(+)-ATPase, whereas no effect was observed in response to bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) co-transporter. In addition, ΔPD induction by [6]-gingerol was greatly diminished by capsazepine, an inhibitor of the capsaicin receptor TRPV1. These results suggest that [6]-gingerol induced the electrogenic absorption of sodium in the rat colon via TRPV1.
authors: Department of Living Science, Faculty of Home Economics, Tohoku Women's College.
authors: Yo
authors: Y
authors: Tsuchiya
authors: Rina
authors: R
authors: Fujita
authors: Akae
authors: A
authors: Saitou
authors: Nanako
authors: N
authors: Wajima
authors: Fuyuka
authors: F
authors: Aizawa
authors: Akane
authors: A
authors: Iinuma
mesh_terms: D000818:Animals; D002034:Bumetanide / Q000494:pharmacology; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002396:Catechols / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005233:Fatty Alcohols / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D010042:Ouabain / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000494:pharmacology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000378:metabolism; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D002396:Catechols; D004791:Enzyme Inhibitors; D005233:Fatty Alcohols; D049994:Sodium Potassium Chloride Symporter Inhibitors; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D002034:Bumetanide; D010042:Ouabain; C007845:gingerol; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; C071423:capsazepine; D002211:Capsaicin