title: Herb-drug pharmacokinetic interaction of a traditional chinese medicine jia-wei-xiao-yao-san with 5-Fluorouracil in the blood and brain of rat using microdialysis.
abstract: According to a survey from the National Health Insurance Research Database (NHIRD), Jia-Wei-Xiao-Yao-San (JWXYS) is the most popular Chinese medicine for cancer patients in Taiwan. 5-Fluorouracil (5-FU) is a general anticancer drug for the chemotherapy. To investigate the herb-drug interaction of JWXYS on pharmacokinetics of 5-FU, a microdialysis technique coupled with a high-performance liquid chromatography system was used to monitor 5-FU in rat blood and brain. Rats were divided into four parallel groups, one of which was treated with 5-FU (100 mg/kg, i.v.) alone and the remaining three groups were pretreated with a different dose of JWXYS (600, 1200, or 2400 mg/kg/day for 5 consecutive days) followed by a combination with 5-FU. This study demonstrates that 5-FU with JWXYS (600 mg/kg/day or 1200 mg/kg/day) has no significant effect on the pharmacokinetics of 5-FU in the blood and brain. However, JWXYS (2400 mg/kg/day) coadministered with 5-FU extends the elimination half-life and increases the volume of distribution of 5-FU in the blood. The elimination half-life of 5-FU in the brain for the pretreatment group with 2400 mg/kg/day of JWXYS is significantly longer than that for the group treated with 5-FU alone and also reduces the clearance. This study provides practical dosage information for clinical practice and proves the safety of 5-FU coadministered with JWXYS.
authors: Institute of Traditional Medicine, National Yang-Ming University, Taipei 112, Taiwan.
authors: Meng-Hsuan
authors: MH
authors: Chiang
authors: Institute of Traditional Medicine, National Yang-Ming University, Taipei 112, Taiwan.
authors: Li-Wen
authors: LW
authors: Chang
authors: Institute of Traditional Medicine, National Yang-Ming University, Taipei 112, Taiwan.
authors: Ju-Wen
authors: JW
authors: Wang
authors: Institute of Traditional Medicine, National Yang-Ming University, Taipei 112, Taiwan ; National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.
authors: Lie-Chwen
authors: LC
authors: Lin
authors: Institute of Traditional Medicine, National Yang-Ming University, Taipei 112, Taiwan ; Graduate Institute of Acupuncture Science, China Medical University, Taichung 404, Taiwan ; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan ; Department of Education and Research, Taipei City Hospital, Taipei 103, Taiwan.
authors: Tung-Hu
authors: TH
authors: Tsai