title: Swine Dialyzable Spleen Extract as Antiviral Prophylaxis.
abstract: Worldwide, the most highly consumed meat is of porcine origin. The production and distribution of swine meat are affected by diverse health matters, such as influenza and diarrhea, which cause head losses and require the use of antibiotics and other drugs in hog farms. To stimulate newborn piglet immune responses and increase resistance to infections, we developed a spray-drying technique to produce dried swine dialyzable spleen extract (sDSE), an immunomodulator. Based on the size-exclusion ultra performance liquid chromatography quantitative analysis, it was possible to recover up to 58% of the product after the drying process. The biological activity of orally administered dried sDSE increased mouse survival and induced cytokine production in a herpes infection model.
authors: 1 Unit of R&D in Bioprocesses (UDIBI), National School of Biological Sciences, National Polytechnic Institute , Mexico City, Mexico .|2 Department of Psychoimmunology, National Institute of Psychiatry , "Ramón de la Fuente," Mexico City, Mexico .
authors: Giovanna
authors: G
authors: Merchand-Reyes
authors: 2 Department of Psychoimmunology, National Institute of Psychiatry , "Ramón de la Fuente," Mexico City, Mexico .
authors: Lenin
authors: L
authors: Pavón
authors: 1 Unit of R&D in Bioprocesses (UDIBI), National School of Biological Sciences, National Polytechnic Institute , Mexico City, Mexico .|2 Department of Psychoimmunology, National Institute of Psychiatry , "Ramón de la Fuente," Mexico City, Mexico .
authors: Gilberto
authors: G
authors: Pérez-Sánchez
authors: 1 Unit of R&D in Bioprocesses (UDIBI), National School of Biological Sciences, National Polytechnic Institute , Mexico City, Mexico .
authors: Said
authors: S
authors: Vázquez-Leyva
authors: 1 Unit of R&D in Bioprocesses (UDIBI), National School of Biological Sciences, National Polytechnic Institute , Mexico City, Mexico .
authors: Nohemí
authors: N
authors: Salinas-Jazmín
authors: 3 School of Medicine, National Autonomous University of Mexico , Mexico City, Mexico .
authors: Marco
authors: M
authors: Velasco-Velázquez
authors: 1 Unit of R&D in Bioprocesses (UDIBI), National School of Biological Sciences, National Polytechnic Institute , Mexico City, Mexico .
authors: Emilio
authors: E
authors: Medina-Rivero
authors: 1 Unit of R&D in Bioprocesses (UDIBI), National School of Biological Sciences, National Polytechnic Institute , Mexico City, Mexico .|4 Unit of Research, Development and Innovation in Medicine and Biotechnology/Transfer Factor Project (UDIMEB/PFT), National School of Biological Sciences, National Polytechnic Institute , Mexico City, Mexico .
authors: Sonia Mayra
authors: SM
authors: Pérez-Tapia
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D016207:Cytokines / Q000378:metabolism*; D003890:Desiccation / Q000379:methods; D003956:Dialysis; D004195:Disease Models, Animal; D006561:Herpes Simplex / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control*; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008807:Mice, Inbred BALB C; D013154:Spleen; D013552:Swine
chemical_list: D000998:Antiviral Agents; D001688:Biological Products; D016207:Cytokines; D007155:Immunologic Factors
keywords: immunoregulation; piglet food supplement; process development; ultra performance liquid chromatograph