title: Beneficial effect of a low dose of ethanol on liver function and serum urate in rats fed a high-fat diet.
abstract: This study investigated the effects of the consumption of 1% or 2% (v/v) ethanol in drinking water for 12 wk on rats fed a high-fat diet. Body weight gain, food intake, and fluid intake were unaffected by ethanol intake. Adipose tissue weight, and serum glucose and lipids were unaffected. Compared to the control (no ethanol), 1% ethanol intake significantly reduced serum levels of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and ammonia (p<0.05), whereas 2% ethanol intake did so to a lesser extent. Serum urate was significantly lower in both the 1% and 2% ethanol groups than that in the control group (p<0.05). The results suggest a low dose of ethanol has beneficial effects on liver function and serum urate in rats fed a high-fat diet.
authors: Graduate School of Biosphere Science, Hiroshima University.
authors: Aimi
authors: A
authors: Osaki
authors: Yukako
authors: Y
authors: Okazaki
authors: Akiko
authors: A
authors: Kimoto
authors: Hanae
authors: H
authors: Izu
authors: Norihisa
authors: N
authors: Kato
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000502:physiology; D000410:Alanine Transaminase / Q000097:blood; D000641:Ammonia / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake; D000431:Ethanol / Q000008:administration & dosage*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014527:Uric Acid / Q000097:blood*; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D014527:Uric Acid; D000431:Ethanol; D000641:Ammonia; D007770:L-Lactate Dehydrogenase; D000410:Alanine Transaminase