title: Comparison of amlodipine with cilnidipine on antihypertensive efficacy and incidence of pedal edema in mild to moderate hypertensive individuals: A prospective study.
abstract: To compare amlodipine with cilnidipine on antihypertensive efficacy and incidence of pedal edema in hypertensive individuals. This was a three months prospective, observational study done at the tertiary care center of Karnataka, India. A total number of 60 (n = 60) newly diagnosed hypertensives (≥140/90) of either gender, attending outpatient department of medicine, were included in the study. Out of 60 patients, 30 patients who have been prescribed tablet amlodipine 5-10 mg/day and the other 30 who have been prescribed tablet cilnidipine 10-20 mg/day orally by the consulting physician, depending upon the severity of hypertension were followed every fortnight, screened for the presence of pedal edema and blood pressure control over a period of 3 months. Antihypertensive efficacy between two groups was compared by unpaired t-test and incidence of pedal edema was compared by Fisher's exact test. Of 30 patients in the amlodipine group, 19 patients presented with pedal edema (63.3%) and 2 patients (6.66%) in cilnidipine group presented with pedal edema during the study period. There was a significant difference in the incidence of pedal edema between amlodipine and cilnidipine group (P < 0.05), but no significant difference was found in the antihypertensive efficacy of amlodipine and cilnidipine (P > 0.05). Both amlodipine and cilnidipine have shown equal efficacy in reducing blood pressure in hypertensive individuals. But cilnidipine being N-type and L-type calcium channel blocker, associated with lower incidence of pedal edema compared to only L-type channel blocked by amlodipine.
authors: Department of Pharmacology, Yenepoya Medical College, Yenepoya University, Mangalore, India.
authors: Prabhakar
authors: P
authors: Adake
authors: Department of Pharmacology, Oxford Medical College, Bangaluru, Karnataka, India.
authors: H S
authors: HS
authors: Somashekar
authors: Department of Pharmacology, Yenepoya Medical College, Yenepoya University, Mangalore, India.
authors: P K
authors: PK
authors: Mohammed Rafeeq
authors: Department of Restorative Sciences, Al Farabi College, Riyadh, Saudi Arabia.
authors: Dilshad
authors: D
authors: Umar
authors: Department of Restorative Sciences, Al Farabi College, Riyadh, Saudi Arabia.
authors: Bahija
authors: B
authors: Basheer
authors: Department of Restorative Sciences, Al Farabi College, Riyadh, Saudi Arabia.
authors: Kusai
authors: K
authors: Baroudi
keywords: Blood pressure; N-type and T-type calcium channels; calcium channel blockers