title: Vitamin E-TPGS stabilized self-assembled tripeptide nanostructures for drug delivery.
abstract: Self-assembled peptides and specifically small peptide based nanostructures have been the focus of research in past decade due to their potential biological applications. In this study, we prepared a protected peptide, Boc-Pro-Phe-Gly-OMe, which self-assembled in aqueous solutions leading to the formation of nanostructures and ability to act as a drug carrier. Dynamic light scattering (DLS) measurements showed nanostructures with average size of 119.6 nm containing hydrophobic core, wherein hydrophobic drugs, viz, eosin, aspirin and curcumin, were successfully encapsulated. These encapsulated nanostructures, were further stabilized with Vitamin E-TPGS. In-vitro drug release studies revealed the release of drugs in controlled fashion from the nanostructures. The results advocate the potential of the proposed peptide nanostructures as controlled drug delivery systems and could be used in other biomedical applications.
authors: Santosh
authors: S
authors: Yadav
authors: Vartika
authors: V
authors: Rai
authors: Manohar
authors: M
authors: Mahato
authors: Mahak
authors: M
authors: Singh
authors: Smriti Rekha
authors: SR
authors: Deka
authors: Nucleic Acids Research Laboratory, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi - 110007, India. ashwani@igib.res.in.
authors: Ashwani Kumar
authors: AK
authors: Sharma
mesh_terms: D001241:Aspirin / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000378:metabolism / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D004801:Eosine Yellowish-(YS) / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects; D061986:MCF-7 Cells; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D009842:Oligopeptides / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D009842:Oligopeptides; D014810:Vitamin E; D011092:Polyethylene Glycols; D003474:Curcumin; C014225:tocophersolan; D001241:Aspirin; D004801:Eosine Yellowish-(YS)