title: Longitudinal stability of medication adherence among adolescent solid organ transplant recipients.
abstract: Solid organ transplantation requires ongoing adherence to immunosuppressants and other medications. Although adolescence is a risk factor for poor medication-taking, little is known about the patterns of adherence within individuals over time. This study aimed to examine the stability of adherence over time using three different assessment techniques. Sixty-six AYA transplant recipients and/or their caregiver completed interviews of adherence at baseline and at least one yr later. Serum immunosuppressant assay levels were collected via medical chart review. Non-adherence percentages based on AYA report, caregiver report, and bioassay did not differ from Time 1 to Time 2. However, correlations for these measures across time were non-significant. Further, the majority of AYAs shifted to a different adherence category from Time 1 to Time 2. Overall, these results demonstrate individual variability in non-adherence over the course of adolescence and young adulthood and highlight the importance of frequent assessment across time for solid organ transplant recipients.
authors: Division of Behavioral Medicine and Clinical Psychology, Center for Adherence and Self-Management, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors: Kristin A
authors: KA
authors: Loiselle
authors: Ana M
authors: AM
authors: Gutierrez-Colina
authors: Cyd K
authors: CK
authors: Eaton
authors: Laura E
authors: LE
authors: Simons
authors: Katie A
authors: KA
authors: Devine
authors: Laura L
authors: LL
authors: Mee
authors: Ronald L
authors: RL
authors: Blount
mesh_terms: D000293:Adolescent; D001681:Biological Assay; D017028:Caregivers; D002648:Child; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000097:blood / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008297:Male; D055118:Medication Adherence; D016377:Organ Transplantation / Q000523:psychology; D011788:Quality of Life; D011795:Surveys and Questionnaires; D066027:Transplant Recipients; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents
keywords: adherence; adolescents; solid organ transplantation