title: Treatment of acute non-anion gap metabolic acidosis.
abstract: Acute non-anion gap metabolic acidosis, also termed hyperchloremic acidosis, is frequently detected in seriously ill patients. The most common mechanisms leading to this acid-base disorder include loss of large quantities of base secondary to diarrhea and administration of large quantities of chloride-containing solutions in the treatment of hypovolemia and various shock states. The resultant acidic milieu can cause cellular dysfunction and contribute to poor clinical outcomes. The associated change in the chloride concentration in the distal tubule lumen might also play a role in reducing the glomerular filtration rate. Administration of base is often recommended for the treatment of acute non-anion gap acidosis. Importantly, the blood pH and/or serum bicarbonate concentration to guide the initiation of treatment has not been established for this type of metabolic acidosis; and most clinicians use guidelines derived from studies of high anion gap metabolic acidosis. Therapeutic complications resulting from base administration such as volume overload, exacerbation of hypertension and reduction in ionized calcium are likely to be as common as with high anion gap metabolic acidosis. On the other hand, exacerbation of intracellular acidosis due to the excessive generation of carbon dioxide might be less frequent than in high anion gap metabolic acidosis because of better tissue perfusion and the ability to eliminate carbon dioxide. Further basic and clinical research is needed to facilitate development of evidence-based guidelines for therapy of this important and increasingly common acid-base disorder.
authors: Medical and Research Services VHAGLA Healthcare System, Division of Nephrology, VHAGLA Healthcare System , David Geffen School of Medicine at UCLA , Los Angeles, CA 90095-1689 , USA ; Division of Nephrology , David Geffen School of Medicine at UCLA , Los Angeles, CA , USA.
authors: Jeffrey A
authors: JA
authors: Kraut
authors: Division of Nephrology , David Geffen School of Medicine at UCLA , Los Angeles, CA , USA.
authors: Ira
authors: I
authors: Kurtz
keywords: acidemia; base therapy; bicarbonate; hyperchloremic acidosis; non-anion gap acidosis