title: Analgesic and anti-inflammatory effects of aqueous extract of leaves of Pentatropis capensis Linn. f. (Bullock).
abstract: BACKGROUND
  Herbal analgesic and anti-inflammatory remedies are preferred much because of lesser side effects and also a lower tendency for habit formation. Pentatropis capensis is such an analgesic and anti-inflammatory drug which is popular among folklore remedies for various injuries and inflammatory problems. It is called by the name of Kākanāsikā in Ayurvedic works. This study was designed to investigate the analgesic, and anti-inflammatory effects of aqueous extract of P. capensis leaves (AEPC) in rats.
  
  
  METHODS
  AEPC was assessed for Analgesic effect through radiant heat tail-flick model and anti-inflammatory effect through carrageenan-induced paw edema model on Wistar strain of albino rats.
  
  
  RESULTS
  Pentatropis capensis leaves aqueous extract showed significant (P < 0.001) increase in the duration of latency of tail flick response at the dose levels of 450 mg/kg, p.o. as compared to the control group. Similarly, the similar dose level produced significant (P < 0.01) anti-inflammatory effect against acute paw edema after 3 h of carrageenan induction when compared to the control group.
  
  
  CONCLUSIONS
  The observed effects were comparable with the standard drug-treated group thus demonstrating effective central analgesic and acute anti-inflammatory potentials of the P. capensis leaves aqueous extract and the observations substantiate its folklore use as an analgesic and anti-inflammatory.
authors: Department of Dravyaguna, Institute of Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
authors: Saikat
authors: S
authors: Chowdhury
authors: Department of Dravyaguna, Institute of Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
authors: K
authors: K
authors: Nishteswar
authors: Department of Pharmacology Laboratory, Institute of Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
authors: Mukesh Kumar
authors: MK
authors: Nariya
keywords: Carrageenan; Pentatropis capensis; paw edema; plethysmograph; tail flick response