title: CranialCloud: a cloud-based architecture to support trans-institutional collaborative efforts in neurodegenerative disorders.
abstract: OBJECTIVE
  Neurological diseases have a devastating impact on millions of individuals and their families. These diseases will continue to constitute a significant research focus for this century. The search for effective treatments and cures requires multiple teams of experts in clinical neurosciences, neuroradiology, engineering, and industry. Hence, the need to communicate a large amount of information with accuracy and precision is more necessary than ever for this specialty.
  
  
  METHODS
  In this paper, we present a distributed system that supports this vision, which we call the CranialVault Cloud (CranialCloud). It consists in a network of nodes, each with the capability to store and process data, that share the same spatial normalization processes, thus guaranteeing a common reference space. We detail and justify design choices, the architecture and functionality of individual nodes, the way these nodes interact, and how the distributed system can be used to support inter-institutional research.
  
  
  RESULTS
  We discuss the current state of the system that gathers data for more than 1,600 patients and how we envision it to grow.
  
  
  CONCLUSIONS
  We contend that the fastest way to find and develop promising treatments and cures is to permit teams of researchers to aggregate data, spatially normalize these data, and share them. The CranialVault system is a system that supports this vision.
authors: Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA, pf.dhaese@vanderbilt.edu.
authors: Pierre-François
authors: PF
authors: D'Haese
authors: Peter E
authors: PE
authors: Konrad
authors: Srivatsan
authors: S
authors: Pallavaram
authors: Rui
authors: R
authors: Li
authors: Priyanka
authors: P
authors: Prassad
authors: William
authors: W
authors: Rodriguez
authors: Benoit M
authors: BM
authors: Dawant
mesh_terms: D000067917:Cloud Computing; D003195:Computer Communication Networks; D003299:Cooperative Behavior; D006801:Humans; D019636:Neurodegenerative Diseases; D012106:Research