title: Increased cognition connectivity network in major depression disorder: a FMRI study.
abstract: OBJECTIVE
  Evidence of the brain network involved in cognitive dysfunction has been inconsistent for major depressive disorder (MDD), especially during early stage of MDD. This study seeks to examine abnormal cognition connectivity network (CCN) in MDD within the whole brain.
  
  
  METHODS
  Sixteen patients with MDD and 16 health controls were scanned during resting-state using 3.0 T functional magnetic resonance imaging (fMRI). All patients were first episode without any history of antidepressant treatment. Both the left and right dorsolateral prefrontal cortex (DLPFC) were used as individual seeds to identify CCN by the seed-target correlation analysis. Two sample t test was used to calculate between-group differences in CCN using fisher z-transformed correlation maps.
  
  
  RESULTS
  The CCN was constructed by bilateral seed DLPFC in two groups separately. Depressed subjects exhibited significantly increased functional connectivity (FC) by left DLPFC in one cluster, overlapping middle frontal gyrus, BA7, BA43, precuneus, BA6, BA40, superior temporal gyrus, BA22, inferior parietal lobule, precentral gyrus, BA4 and cingulate gyrus in left cerebrum. Health controls did not show any cluster with significantly greater FC compared to depressed subjects in left DLPFC network. There was no significant difference of FC in right DLPFC network between depressed subjects and the health controls.
  
  
  CONCLUSIONS
  There are differences in CCN during early stage of MDD, as identified by increased FCs among part of frontal gyrus, parietal cortex, cingulate cortex, and BA43, BA22, BA4 with left DLPFC. These brain areas might be involved in the underlying mechanisms of cognitive dysfunction in MDD.
authors: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China.
authors: Ting
authors: T
authors: Shen
authors: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China.
authors: Cao
authors: C
authors: Li
authors: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China.
authors: Biao
authors: B
authors: Wang
authors: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China.
authors: Wei-Min
authors: WM
authors: Yang
authors: Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China.
authors: Chen
authors: C
authors: Zhang
authors: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China.
authors: Zhiguo
authors: Z
authors: Wu
authors: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China.
authors: Mei-Hui
authors: MH
authors: Qiu
authors: Department of Medical Imaging, Shanghai Fifth People's Hospital, Shanghai, China.
authors: Jun
authors: J
authors: Liu
authors: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China. ; Huashan Hospital, Fudan University, Shanghai, China.
authors: Yi-Feng
authors: YF
authors: Xu
authors: Division of Mood Disorders, Psychiatry Department, Shanghai Mental Health Center, Shanghai Jiaotong University, Shanghai, China.
authors: Dai-Hui
authors: DH
authors: Peng
keywords: Cognition connectivity network; Depression; First episode; Functional magnetic resonance imaging; Resting state