title: MiR-218 mediates tumorigenesis and metastasis: Perspectives and implications.
abstract: MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. As a highly conserved miRNA across a variety of species, microRNA-218 (miR-218) was found to play pivotal roles in tumorigenesis and progression. A group of evidence has demonstrated that miR-218 acts as a tumor suppressor by targeting many oncogenes related to proliferation, apoptosis and invasion. In this review, we provide a complex overview of miR-218, including its regulatory mechanisms, known functions in cancer and future challenges as a potential therapeutic target in human cancers.
authors: Institute Guangzhou of Advanced Technology, Chinese Academy of Sciences, Guangzhou, PR China; Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.
authors: Ying-fei
authors: YF
authors: Lu
authors: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; Department of Anatomical and Cellular Pathology, State Key Laboratory of Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.
authors: Li
authors: L
authors: Zhang
authors: School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
authors: Mary Miu Yee
authors: MM
authors: Waye
authors: Institute Guangzhou of Advanced Technology, Chinese Academy of Sciences, Guangzhou, PR China; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. Electronic address: wm.fu@giat.ac.cn.
authors: Wei-ming
authors: WM
authors: Fu
authors: Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China. Electronic address: zhangjf06@cuhk.edu.hk.
authors: Jin-fang
authors: JF
authors: Zhang
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009362:Neoplasm Metastasis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: C547471:MIRN218 microRNA, human; D035683:MicroRNAs
keywords: Metastasis; Target genes; Tumorigenesis; miR-218