title: RISK OF RETINAL VEIN OCCLUSION IN PATIENTS WITH PSORIASIS: A Population-Based Cohort Study.
abstract: OBJECTIVE
  To investigate the risk of developing retinal vein occlusion (RVO) in patients with psoriasis.
  
  
  METHODS
  In this retrospective population-based cohort study, 30,198 patients with psoriasis (Psoriasis((+)) group) and 30,198 controls without psoriasis (Psoriasis((−)) group) between 2001 and 2006 from the Taiwan National Health Insurance Research Database were selected.
  
  
  RESULTS
  The incidence of RVO was 1.46 times higher in the Psoriasis((+)) group than in the Psoriasis((−)) group (3.61 vs. 2.47/10,000 person-years) (adjusted hazard ratio = 1.50; 95% confidence interval = 1.07-2.10) calculated using Cox proportional hazard regression. Age was an independent risk factor for RVO (adjusted hazard ratio: 11.9 for patients 65 years or older vs. 1.00 for those 0-49 years old). In the 65 years or older Psoriasis((+)) group, the incidence of developing RVO was 1.97 times higher (95% confidence interval = 1.19-3.26) than in the 65 years or older Psoriasis((−)) group. In Psoriasis((+)) women, the incidence of developing RVO was 1.82 times higher (95% = 1.05-3.14) than in Psoriasis((−)) women. For the subgroup with comorbid hypertension, the incidence of developing RVO was 2.07 times higher (95% confidence interval = 1.22-3.50) in the Psoriasis((+)) group than in the Psoriasis((−)) group.
  
  
  CONCLUSIONS
  Psoriasis was significantly associated with a higher risk of developing RVO.
authors: *Department of Ophthalmology, Chi Mei Medical Center, Liou-Ying, Tainan City, Taiwan; †Department of Nursing, Min Hwei College of Health Care Management, Tainan City, Taiwan; ‡Department of Medical Research, Chi Mei Medical Center, Yung-Kang District, Tainan City, Taiwan; §Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and Science, Ren De District, Tainan City, Taiwan; ¶Department of Dermatology, Chi Mei Medical Center, Yung-Kang District, Tainan City, Taiwan; **Center for General Education, Southern Taiwan University of Science and Technology, Tainan, Taiwan; ††Department of Otolaryngology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; and ‡‡Department of Otolaryngology, Chi Mei Medical Center, Yung-Kang District, Tainan City, Taiwan.
authors: Yung-Chang
authors: YC
authors: Yen
authors: Shih-Feng
authors: SF
authors: Weng
authors: Feng-Jie
authors: FJ
authors: Lai
authors: Yung-Song
authors: YS
authors: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data; D016016:Proportional Hazards Models; D011565:Psoriasis / Q000150:complications*; D012170:Retinal Vein Occlusion / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology