title: Characterization of Hip Morphology in Children With Mucopolysaccharidosis Types I and II.
abstract: BACKGROUND
  The purpose of this study is to describe the natural history of hip morphology in patients with mucopolysaccharidoses (MPS) I and MPS II.
  
  
  METHODS
  This is a retrospective radiographic analysis of 88 hips in 44 children with MPS I and II. Radiographs were examined to determine hip migration, femoral head sphericity, and acetabular dysplasia at different ages throughout childhood. In individual hips, change in morphology and rate of change were analyzed.
  
  
  RESULTS
  There was a high rate of hip migration and femoral head dysplasia in both MPS I and MPS II. Progressive migration was seen in three quarters of hips and progressive femoral head deformity in over half of hips. Acetabular dysplasia was variable, ranging from normal to severely dysplastic, but did not change with time. Overall, hips were more dysplastic in MPS I than MPS II.
  
  
  CONCLUSIONS
  Hip morphology is variable in MPS I and MPS II ranging from almost normal to severely dysplastic. Some hips do not deteriorate with time and thus surgical intervention may not be necessary in all cases. Deterioration is slow allowing time to plan a holistic approach to treatment.
  
  
  METHODS
  Level IV-case series.
authors: Department of Orthopaedic Surgery, Great Ormond Street Hospital for Children, London, UK.
authors: Elizabeth
authors: E
authors: Ashby
authors: Markus
authors: M
authors: Baker
authors: Deborah M
authors: DM
authors: Eastwood
mesh_terms: D000077:Acetabulum / Q000000981:diagnostic imaging*; D000293:Adolescent; D001848:Bone Diseases, Developmental / Q000000981:diagnostic imaging* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005270:Femur Head / Q000000981:diagnostic imaging*; D006617:Hip Dislocation; D006618:Hip Dislocation, Congenital / Q000000981:diagnostic imaging* / Q000209:etiology; D006621:Hip Joint / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008059:Mucopolysaccharidosis I / Q000150:complications / Q000000981:diagnostic imaging*; D016532:Mucopolysaccharidosis II / Q000150:complications / Q000000981:diagnostic imaging*; D011859:Radiography; D012189:Retrospective Studies