title: The CPTAC Data Portal: A Resource for Cancer Proteomics Research.
abstract: The Clinical Proteomic Tumor Analysis Consortium (CPTAC), under the auspices of the National Cancer Institute's Office of Cancer Clinical Proteomics Research, is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of proteomic technologies and workflows to clinical tumor samples with characterized genomic and transcript profiles. The consortium analyzes cancer biospecimens using mass spectrometry, identifying and quantifying the constituent proteins and characterizing each tumor sample's proteome. Mass spectrometry enables highly specific identification of proteins and their isoforms, accurate relative quantitation of protein abundance in contrasting biospecimens, and localization of post-translational protein modifications, such as phosphorylation, on a protein's sequence. The combination of proteomics, transcriptomics, and genomics data from the same clinical tumor samples provides an unprecedented opportunity for tumor proteogenomics. The CPTAC Data Portal is the centralized data repository for the dissemination of proteomic data collected by Proteome Characterization Centers (PCCs) in the consortium. The portal currently hosts 6.3 TB of data and includes proteomic investigations of breast, colorectal, and ovarian tumor tissues from The Cancer Genome Atlas (TCGA). The data collected by the consortium is made freely available to the public through the data portal.
authors: Nathan J
authors: NJ
authors: Edwards
authors: ‡ESAC, Inc., Rockville, Maryland 20850, United States.
authors: Mauricio
authors: M
authors: Oberti
authors: ‡ESAC, Inc., Rockville, Maryland 20850, United States.
authors: Ratna R
authors: RR
authors: Thangudu
authors: ‡ESAC, Inc., Rockville, Maryland 20850, United States.
authors: Shuang
authors: S
authors: Cai
authors: Peter B
authors: PB
authors: McGarvey
authors: ‡ESAC, Inc., Rockville, Maryland 20850, United States.
authors: Shine
authors: S
authors: Jacob
authors: Subha
authors: S
authors: Madhavan
authors: ‡ESAC, Inc., Rockville, Maryland 20850, United States.
authors: Karen A
authors: KA
authors: Ketchum
mesh_terms: D035843:Biomedical Research; D030562:Databases, Protein; D006801:Humans; D016247:Information Storage and Retrieval; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D040901:Proteomics
chemical_list: D009363:Neoplasm Proteins
keywords: Clinical Proteomics Tumor Analysis Consortium; Data portal; The Cancer Genome Atlas; mass spectrometry; proteomics