title: Resistant starch: a functional food that prevents DNA damage and chemical carcinogenesis.
abstract: Resistant starch is formed from starch and its degradation products and is not digested or absorbed in the intestine; thus, it is characterized as a fiber. Because fiber intake is associated with the prevention of DNA damage and cancer, the potential antigenotoxic, antimutagenic, and anticarcinogenic capabilities of resistant starch from green banana flour were evaluated. Animals were treated with 1,2-dimethylhydrazine and their diet was supplemented with 10% green banana flour according to the following resistant starch protocols: pretreatment, simultaneous treatment, post-treatment, and pre + continuous treatment. The results demonstrated that resistant starch is not genotoxic, mutagenic, or carcinogenic. The results suggest that resistant starch acts through desmutagenesis and bio-antimutagenesis, as well as by reducing aberrant crypt foci, thereby improving disease prognosis. These findings imply that green banana flour has therapeutic properties that should be explored for human dietary applications.
authors: Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica-CeTroGen, Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.
authors: S D
authors: SD
authors: Navarro
authors: Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica-CeTroGen, Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.
authors: M O
authors: MO
authors: Mauro
authors: Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica-CeTroGen, Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.
authors: J R
authors: JR
authors: Pesarini
authors: Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, Brasil.
authors: F M
authors: FM
authors: Ogo
authors: Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica-CeTroGen, Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil rodrigo.oliveira@ufms.br.
authors: R J
authors: RJ
authors: Oliveira
mesh_terms: D058739:Aberrant Crypt Foci; D000818:Animals; D063646:Carcinogenesis / Q000187:drug effects*; D015179:Colorectal Neoplasms / Q000517:prevention & control; D020552:Comet Assay; D004249:DNA Damage; D004043:Dietary Fiber / Q000008:administration & dosage*; D004127:Dimethylhydrazines / Q000009:adverse effects; D004195:Disease Models, Animal; D005433:Flour; D005511:Food Handling; D055951:Functional Food; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D028521:Musa; D013213:Starch / Q000737:chemistry*
chemical_list: D004043:Dietary Fiber; D004127:Dimethylhydrazines; C013958:dimazine; D013213:Starch