title: Long-term survival in patients with metastatic gastric and gastroesophageal cancer treated with surgery.
abstract: BACKGROUND
  The purpose of this study was to determine the survival of patients with metastatic gastric cancer treated with surgery.
  
  
  METHODS
  We reviewed the medical records of 7,404 patients with gastric or gastroesophageal cancer seen from January 1995 to August 2012 at MD Anderson Cancer Center and identified patients with stage IV disease treated with surgery. Kaplan-Meier curves were created to compare overall survival (OS) between groups.
  
  
  RESULTS
  Of the 82 patients who met inclusion criteria, sites of metastatic disease included peritoneum (N = 34, 42%), positive cytology only (N = 17, 21%), distant lymph nodes (N = 12, 15%), and distant organs (N = 19, 23%). The median time from initial cancer diagnosis to surgery for metastatic disease was 10 months (range, 0-70). Surgery included exploratory surgery only (N = 16, 20%), primary tumor resection with or without resection of distant disease (N = 50, 61%), and distant disease resection only (N = 16, 20%). Median follow-up for living patients was 3 years (range, 0.1-14). Median survival for all patients was 1.5 years (range, 0.1-14). Five year OS for patients with peritoneal metastases, positive cytology only, distant lymph nodes, and distant organ involvement was 13, 42, 20, and 34%, respectively.
  
  
  CONCLUSIONS
  Surgery in the setting of metastatic disease is an uncommon clinical scenario and has a considerable risk of exploration without resection, although long-term survival is possible.
authors: Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.
authors: Brian
authors: B
authors: Badgwell
authors: Sinchita
authors: S
authors: Roy-Chowdhuri
authors: Yi-Ju
authors: YJ
authors: Chiang
authors: Aurelio
authors: A
authors: Matamoros
authors: Mariela
authors: M
authors: Blum
authors: Keith
authors: K
authors: Fournier
authors: Paul
authors: P
authors: Mansfield
authors: Jaffer
authors: J
authors: Ajani
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D000368:Aged; D004938:Esophageal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D004943:Esophagogastric Junction; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D013997:Time Factors
keywords: gastric cancer; gastroesophageal; metastatic; stage IV; surgery