title: Differences in Gut Microbiota Between Atopic and Healthy Children.
abstract: Although gut microbiota has been studied relatively extensively in the context of allergic diseases, there have been several contradictions between these studies. By applying high-throughput sequencing, we aimed to analyze the differences in gut microbiota between atopic and healthy children at 5 and 12 years of age. 51 stool samples were collected from 14 atopic and 15 healthy children and analyzed with 454 pyrosequencing of the 16S rRNA gene. At the ages of 5 and 12 years, Bacteroides, Prevotella, and Dialister dominated gut microbiota in both atopic and healthy groups of children. Children in the atopic group had lower abundance and prevalence of Akkermansia in gut microbiota than their healthy counterparts. Thus, the composition of gut microbiota does not seem to be significantly different between atopic and healthy children, but lower abundance and prevalence of Akkermansia indicate that this bacterium may accompany or play a role in IgE-mediated atopic diseases.
authors: Institute of Microbiology, University of Tartu, Tartu, Estonia.
authors: Tiina
authors: T
authors: Drell
authors: Anneli
authors: A
authors: Larionova
authors: Tiia
authors: T
authors: Voor
authors: Jaak
authors: J
authors: Simm
authors: Kaja
authors: K
authors: Julge
authors: Kaire
authors: K
authors: Heilman
authors: Vallo
authors: V
authors: Tillmann
authors: Jelena
authors: J
authors: Štšepetova
authors: Epp
authors: E
authors: Sepp
mesh_terms: D001419:Bacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000382:microbiology*; D005260:Female; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D006967:Hypersensitivity / Q000382:microbiology*; D008297:Male