title: Rational pharmacological approaches for cognitive dysfunction and depression in Parkinson's disease.
abstract: Parkinson's disease (PD) is not a single entity but rather a heterogeneous neurodegenerative disorder. The present study aims to conduct a critical systematic review of the literature to describe the main pharmacological strategies to treat cognitive dysfunction and major depressive disorder in PD patients. We performed a search of articles cited in PubMed from 2004 to 2014 using the following MeSH terms (Medical subject headings) "Parkinson disease"; "Delirium," "Dementia," "Amnestic," "Cognitive disorders," and "Parkinson disease"; "depression," "major depressive disorder," "drug therapy." We found a total of 71 studies related to pharmacological treatment in cognitive dysfunction and 279 studies for pharmacological treatment in major depressive disorder. After fulfillment of all the inclusion and exclusion criteria, 13 articles remained for cognitive dysfunction and 11 for major depressive disorder, which are presented and discussed in this study. Further research into non-motor symptoms of PD may provide insights into mechanisms of neurodegeneration, and provide better quality of life by using rational drugs.
authors: Unidad de Trastornos del Movimiento y Sueño, Hospital General Ajusco Medio, Secretaría de Salud , Mexico City , Mexico.
authors: Maritza
authors: M
authors: Sandoval-Rincón
authors: Unidad de Trastornos del Movimiento y Sueño, Hospital General Ajusco Medio, Secretaría de Salud , Mexico City , Mexico ; Programa de Parkinson y Movimientos Anormales, Hospital de Clínicas "José de San Martín," Universidad de Buenos Aires , Buenos Aires , Argentina.
authors: Michel
authors: M
authors: Sáenz-Farret
authors: Unidad de Trastornos del Movimiento y Sueño, Hospital General Dr. Manuel Gea González, Secretaría de Salud , Mexico City , Mexico.
authors: Adán
authors: A
authors: Miguel-Puga
authors: Programa de Parkinson y Movimientos Anormales, Hospital de Clínicas "José de San Martín," Universidad de Buenos Aires , Buenos Aires , Argentina.
authors: Federico
authors: F
authors: Micheli
authors: Unidad de Trastornos del Movimiento y Sueño, Hospital General Ajusco Medio, Secretaría de Salud , Mexico City , Mexico ; Unidad de Trastornos del Movimiento y Sueño, Hospital General Dr. Manuel Gea González, Secretaría de Salud , Mexico City , Mexico.
authors: Oscar
authors: O
authors: Arias-Carrión
keywords: Parkinson’s disease; cognitive disorders; dementia; depression; drug therapy; major depressive disorder; non-motor symptoms