title: Gambling disorder and its relationship with substance use disorders: implications for nosological revisions and treatment.
abstract: BACKGROUND
  Gambling disorder, recognized by the DSM-5 as a behavioral addiction, affects .4-1.6% of adults worldwide, and is highly comorbid with other mental health disorders, particularly substance use disorders (SUDs).
  
  
  OBJECTIVE
  To provide a concise primer on the relationship between gambling disorder and SUDs, focusing on phenomenology/clinical presentation, co-morbidity, familiality, cognition, neuroanatomy/neurochemistry, and treatment.
  
  
  METHODS
  Selective review of the literature.
  
  
  RESULTS
  Scientific evidence shows that gambling and SUDs have consistently high rates of comorbidity, similar clinical presentations, and some genetic and physiological overlap. Several treatment approaches show promise for gambling disorder, some of which have previously been effective for SUDs.
  
  
  CONCLUSIONS
  It is hoped that recognition of overlap between gambling disorder and SUDs in terms of phenomenology and neurobiology will signal novel treatment approaches and raise the profile of this neglected condition.
authors: Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois.
authors: Jon E
authors: JE
authors: Grant
authors: Department of Psychiatry and MRC/Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK.|Cambridge and Peterborough NHS Foundation Trust, Cambridge, UK.
authors: Samuel R
authors: SR
authors: Chamberlain
mesh_terms: D015897:Comorbidity; D005715:Gambling / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology / Q000628:therapy; D006801:Humans; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology / Q000628:therapy