title: The effect of lipoic acid administration on the urinary excretion of thiocyanate in rats exposed to potassium cyanide.
abstract: The oxidation of cyanide (CN-) to a much less toxic thiocyanate (SCN-) is the main in vivo biochemical pathway for CN- detoxification. SCN- is excreted mainly in urine. This study was performed to investigate the effect of lipoic acid (LA) on the urinary excretion of thiocyanate (SCN-; rhodanate) in rats. Groups of the animals were treated intraperitoneally (i.p.) as follows: group 1: potassium cyanide (KCN) (1 mg/kg); group 2: KCN (1 mg/kg) + LA (100 mg/kg). Urine was collected for 24 h and the pooled samples were examined for SCN- levels. The obtained results indicated that the treatment of animals with potassium cyanide and LA in combination significantly increased the urinary excretion of SCN- in comparison with the respective values in the KCN-alone-treated group. It indicates that LA increased the rate of CN- detoxification in rats.
authors: Anna
authors: A
authors: Bilska-Wilkosz
authors: Magdalena
authors: M
authors: Dudek
authors: Joanna
authors: J
authors: Knutelska
authors: Lidia
authors: L
authors: Włodek
mesh_terms: D000818:Animals; D008297:Male; D011190:Potassium Cyanide / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D008063:Thioctic Acid / Q000494:pharmacology*; D013861:Thiocyanates / Q000652:urine*
chemical_list: D013861:Thiocyanates; D008063:Thioctic Acid; D011190:Potassium Cyanide; C031760:thiocyanate