title: "Anion clamp" allows flexible protein to impose coordination geometry on metal ions.
abstract: X-ray crystal structures of human serum transferrin (77 kDa) with Yb(III) or Fe(III) bound to the C-lobe and malonate as the synergistic anion show that the large Yb(III) ion causes the expansion of the metal binding pocket while octahedral metal coordination geometry is preserved, an unusual geometry for a lanthanide ion.
authors: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, P. R. China. hsun@hku.hk.
authors: Minji
authors: M
authors: Wang
authors: Tsz Pui
authors: TP
authors: Lai
authors: Li
authors: L
authors: Wang
authors: Hongmin
authors: H
authors: Zhang
authors: Nan
authors: N
authors: Yang
authors: Peter J
authors: PJ
authors: Sadler
authors: Hongzhe
authors: H
authors: Sun
mesh_terms: D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D007477:Ions / Q000737:chemistry; D008958:Models, Molecular; D014168:Transferrin / Q000737:chemistry*; D015018:Ytterbium / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; D007477:Ions; D014168:Transferrin; D015018:Ytterbium