title: Inflammasome inhibition: putting out the fire.
abstract: NLRP3-inflammasome activates caspase-1 and processes pro-IL-1β and pro-IL-18 into the active cytokines. Two recent studies describe specific inhibitors of NLRP3 inflammasome that inhibit IL-1β release and inflammation. The specificity and potency of these compounds gives hope that a targeted approach to inhibit NLRP3-driven inflammation may be just around the corner.
authors: Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: mihai.netea@radboudumc.nl.
authors: Mihai G
authors: MG
authors: Netea
authors: Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: leo.joosten@radboudumc.nl.
authors: Leo A B
authors: LA
authors: Joosten
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000494:pharmacology*; D000818:Animals; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D020170:Caspase 1 / Q000187:drug effects*; D056587:Cryopyrin-Associated Periodic Syndromes / Q000188:drug therapy*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy*; D005260:Female; D006576:Heterocyclic Compounds, 4 or More Rings / Q000627:therapeutic use*; D006801:Humans; D058847:Inflammasomes / Q000037:antagonists & inhibitors*; D053583:Interleukin-1beta / Q000187:drug effects*; D008297:Male; D009000:Monocytes / Q000187:drug effects*; D009103:Multiple Sclerosis; D013450:Sulfones / Q000627:therapeutic use*
chemical_list: D002352:Carrier Proteins; D006576:Heterocyclic Compounds, 4 or More Rings; D058847:Inflammasomes; D053583:Interleukin-1beta; D013450:Sulfones; D020170:Caspase 1; D020155:3-Hydroxybutyric Acid