title: Determinants of peak VO2 in heart transplant recipients.
abstract: OBJECTIVE
  To establish the determinants of the peak VO2 in heart transplant recipients.
  
  
  METHODS
  Patient's assessment was performed in two consecutive days. In the first day, patients performed the heart rate variability assessment followed by a cardiopulmonary exercise test. In the second day, patients performed a resting echocardiography. Heart transplant recipients were eligible if they were in a stable condition and without any evidence of tissue rejection diagnosed by endomyocardial biopsy. Patients with pacemaker, noncardiovascular functional limitations such as osteoarthritis and chronic obstructive pulmonary disease were excluded from this study.
  
  
  RESULTS
  Sixty patients (68% male, 48 years and 64 months following heart transplantation) were assessed. Multivariate analysis selected the following variables: receptor's gender (P=0.001), receptor age (P=0.049), receptor Body Mass Index (P=0.005), heart rate reserve (P <0.0001), left atrium diameter (P=0.016). Multivariate analysis showed r=0.77 and r2=0.6 with P <0.001. Equation: peakVO2=32.851 - 3.708 (receptor gender) - 0.067 (receptor age) - 0.318 (receptor BMI) + 0.145 (heart rate reserve) - 0.111 (left atrium diameter).
  
  
  CONCLUSIONS
  The determinants of the peak VO2 in heart transplant recipients were: receptor sex, age, Body Mass Index, heart rate reserve and left atrium diameter. Heart rate reserve was the unique variable positively associated with peak VO2. This data suggest the importance of the sympathetic reinnervation in peak VO2 in heart transplant recipients.
authors: Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, Brazil.
authors: Vitor
authors: V
authors: Oliveira Carvalho
authors: Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, Brazil.
authors: Guilherme Veiga
authors: GV
authors: Guimarães
authors: Marcelo Luiz Campos
authors: ML
authors: Vieira
authors: Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, Brazil.
authors: Marcelo Luiz
authors: ML
authors: Campos-Vieira
authors: Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, Brazil.
authors: Aparecida Maria
authors: AM
authors: Catai
authors: Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, Brazil.
authors: Vagner
authors: V
authors: Oliveira-Carvalho
authors: Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, Brazil.
authors: Silvia Moreira
authors: SM
authors: Ayub-Ferreira
authors: Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, Brazil.
authors: Edimar Alcides
authors: EA
authors: Bocchi
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006325:Heart Atria / Q000033:anatomy & histology; D006339:Heart Rate / Q000502:physiology; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D012737:Sex Factors; D013997:Time Factors