title: Vaginal Yolk Sac Tumor in an Infant: A Case Report and Literature Review of the Last 30 Years.
abstract: Vaginal yolk sac tumor is a rare malignant germ-cell tumor occurring most commonly in young girls. The treatment has evolved over the last 3 decades from radical surgery to conservative surgery with chemotherapy to chemotherapy alone. Here we present a case of a 6-month-old girl successfully treated with upfront surgery followed by chemotherapy. We include a literature review of studies on vaginal yolk sac tumor published in the last 30 years. We discuss the role of upfront surgery where possible followed by chemotherapy as a safe alternative to chemotherapy alone for the treatment of this rare malignancy.
authors: *Division of Pediatric Hematology/Oncology †Division of Urology ‡Division of Radiology §Division of Anatomical Pathology, McMaster Children's Hospital, Hamilton, Ontario, Canada.
authors: Mihir D
authors: MD
authors: Bhatt
authors: Luis H
authors: LH
authors: Braga
authors: Nina
authors: N
authors: Stein
authors: Jefferson
authors: J
authors: Terry
authors: Carol
authors: C
authors: Portwine
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D003131:Combined Modality Therapy; D018240:Endodermal Sinus Tumor / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery