title: Successful renal transplantation in a patient with a Wiskott-Aldrich syndrome protein (WASP) gene mutation.
abstract: Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency disorder caused by mutations in the WAS protein (WASP) gene. Renal disease progressing to renal failure is a well-recognized complication in patients with WAS. Only a few case reports of renal transplantation have been reported to date. Here, we present a patient with a WASP mutation who suffered from severe atopic eczema, mild thrombocytopenia and only a slightly increased frequency of infections, who then developed IgA nephropathy and consequently underwent renal transplantation, which was successful. This study demonstrates that renal transplantation is possible in patients with WAS, regardless of conceivable complications.
authors: Department of Clinical Immunology and Allergy, St. Anne's University Hospital, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors: Zita
authors: Z
authors: Chovancova
authors: Cardiovascular and Transplant Surgery Centre, Brno, Czech Republic.
authors: Milan
authors: M
authors: Kuman
authors: Department of Clinical Immunology and Allergy, St. Anne's University Hospital, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors: Marcela
authors: M
authors: Vlkova
authors: Department of Clinical Immunology and Allergy, St. Anne's University Hospital, Brno, Czech Republic.|Faculty of Medicine, Masaryk University, Brno, Czech Republic.
authors: Jiri
authors: J
authors: Litzman
mesh_terms: D000293:Adolescent; D005819:Genetic Markers; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D009154:Mutation; D014923:Wiskott-Aldrich Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D051316:Wiskott-Aldrich Syndrome Protein / Q000235:genetics*
chemical_list: D005819:Genetic Markers; C495767:WAS protein, human; D051316:Wiskott-Aldrich Syndrome Protein
keywords: IgA nephropathy; Wiskott-Aldrich syndrome; immunodeficiency; renal transplantation