title: [The glycated hemoglobin: indication, interpretation and limitations].
abstract: HbA1c is defined by the slow and irreversible binding of glucose to the N-terminal valine of one or both of the beta chains of hemoglobin A (HbA). It is a marker that is becoming increasingly important because of its role in both the diagnosis and monitoring of diabetic patients with type 1 and type 2. It reflects glycemic control of two or three months. Learned societies such as the IFCC and NGSP contributed to its standardization, which allows inter-laboratory comparison of results. Its assay uses chromatographic, electrophoretic or immunochemical methods. The HbA1c concentration is expressed in percent and in mmol/mol, and a number that is between 4 and 6% (20 and 42mmol/mol) is desirable. However, HbA1c cannot be used in some cases and fructosamine assay must be considered.
authors: Laboratoire de biochimie, établissement hospitalier universitaire d'Oran 1(er)-Novembre-1954, BP 4166 Ibn Rochd, Oran, Algérie. Electronic address: z-mustapha2@hotmail.fr.
authors: M
authors: M
authors: Zendjabil
mesh_terms: D015415:Biomarkers / Q000097:blood*; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D012015:Reference Standards
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin
keywords: Diabetes; Diabète; Follow-up; Fructosamines; Glycated hemoglobin; HbA(1c); Hémoglobine glyquée; Suivi