title: Ameloblastic fibrosarcoma of the mandible: a case report and brief review of the literature.
abstract: Ameloblastic fibrosarcoma is an uncommon odontogenic tumor composed of a benign epithelial component and a malignant ectomesenchymal component most frequently seen in the third and fourth decades of life. It mainly presents as a painful maxillary or mandibular swelling. Radiographs show a radiolucent mass with ill-defined borders. Radical surgical excision and long-term follow-up are the suggested treatment. We report the case of a 22-year-old female with a 2-month history of an asymptomatic swelling in her left mandible. Examination revealed an exophytic growth measuring 3 × 3 cm extending from the mandibular left first premolar to the second molar. The patient underwent a left hemimandibular resection. Histopathological examination revealed a biphasic tumor composed of inconspicuous islands of benign odontogenic epithelium and an abundant malignant mesenchymal component with marked cellularity, nuclear pleomorphism, hyperchromatism, and moderate mitotic figures with clear margins; one year after the surgical procedure, the patient is clinically and radiologically disease-free.
authors: Pathology Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Abelardo
authors: A
authors: Loya-Solis
authors: Pathology Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Karla Judith
authors: KJ
authors: González-Colunga
authors: Otolaryngology-Head and Neck Surgery Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Cynthia M
authors: CM
authors: Pérez-Rodríguez
authors: Otolaryngology-Head and Neck Surgery Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Natalie Sofía
authors: NS
authors: Ramírez-Ochoa
authors: Pathology Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Luis
authors: L
authors: Ceceñas-Falcón
authors: Pathology Department, University Hospital "Dr. Jose E. Gonzalez" and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico.
authors: Oralia
authors: O
authors: Barboza-Quintana