title: Essential oil based polymeric patch development and evaluating its repellent activity against mosquitoes.
abstract: Essential oil based insect repellents are environment friendly and provide dependable personal protection against the bites of mosquitoes and other blood-sucking insects. In the present study, optimized mixture of three essential oils was embedded into the ethylcellulose (EC) and polyvinylpyrrolidone (PVP K-30) polymers to develop essential oils based patch type mosquito repellent formulation. The developed formulation was characterized for various physico-chemical properties, oil release efficiency and essential oil-polymer interaction. Repellent activity of the formulation was evaluated against Ae. (S) albopictus mosquitoes and compared with commercially available synthetic insecticide based mosquito repellent cream Odomos(®) in the laboratory. The developed patches were 100% flat and there was no interaction between oil components and the excipients. Patches were smooth, homogenous and provided excellent mosquito repellent activity comparable to Odomos(®) under laboratory condition. Morphological and physico-chemical characterization indicated that the formulation was stable and suitable with the polymeric combination. The patch formulation did not show any inhalation toxicity in experimental Wistar rat. The repellent patches developed and evaluated currently, may provide a suitable, eco-friendly, acceptable and safe alternative to the existing synthetic repellent formulations for achieving protection against mosquitoes.
authors: Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur 784001, Assam, India.
authors: Pronobesh
authors: P
authors: Chattopadhyay
authors: Division of Medical Entomology, Defence Research Laboratory, Tezpur 784001, Assam, India. Electronic address: sunildhiman81@gmail.com.
authors: Sunil
authors: S
authors: Dhiman
authors: Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur 784001, Assam, India; Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Guwahati 781017, Assam, India.
authors: Somi
authors: S
authors: Borah
authors: Division of Medical Entomology, Defence Research Laboratory, Tezpur 784001, Assam, India.
authors: Bipul
authors: B
authors: Rabha
authors: Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur 784001, Assam, India.
authors: Aashwin Kumar
authors: AK
authors: Chaurasia
authors: Division of Pharmaceutical Technology, Defence Research Laboratory, Tezpur 784001, Assam, India.
authors: Vijay
authors: V
authors: Veer
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D002482:Cellulose; D002935:Cinnamomum zeylanicum; D031743:Cymbopogon; D005052:Eucalyptus; D007302:Insect Repellents / Q000494:pharmacology*; D007306:Insecticides / Q000494:pharmacology*; D009822:Oils, Volatile / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D011145:Polyvinyls; D011759:Pyrrolidines; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007302:Insect Repellents; D007306:Insecticides; D009822:Oils, Volatile; D010938:Plant Oils; D011145:Polyvinyls; D011759:Pyrrolidines; C505150:poly(N-vinylpyrrolidine); D002482:Cellulose
keywords: Essential oils; Inhalation toxicity; Mosquito repellent; Patch formulation; Polymer