title: Severe intrinsic acute kidney injury associated with therapeutic doses of acetaminophen.
abstract: Acetaminophen is a commonly used medication to manage fever and pain in children and the drug is generally considered to be safe when used at appropriate therapeutic dosages. Recently, we encountered the case of a 3-year-old Japanese girl who suffered from severe intrinsic acute kidney injury (AKI) after therapeutic doses of acetaminophen for a fever due to viral infection. Renal biopsy indicated severe acute tubular necrosis with a significant striped interstitial fibrosis and mild interstitial inflammation. Unfortunately, she developed chronic kidney disease thereafter. This is the youngest case of biopsy-proven severe intrinsic AKI associated with therapeutic doses of acetaminophen. Acetaminophen, even if administered at therapeutic dosages, may be dangerous in selected children, especially with possible pre-existing volume depletion.
authors: Department of Pediatrics, Hirosaki University Hospital, Hirosaki, Japan.
authors: Tatsuya
authors: T
authors: Ito
authors: Shojiro
authors: S
authors: Watanabe
authors: Kazushi
authors: K
authors: Tsuruga
authors: Tomomi
authors: T
authors: Aizawa
authors: Koji
authors: K
authors: Hirono
authors: Etsuro
authors: E
authors: Ito
authors: Kensuke
authors: K
authors: Joh
authors: Hiroshi
authors: H
authors: Tanaka
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000188:drug therapy / Q000821:virology; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D011239:Prednisolone
keywords: acetaminophen; acute kidney injury; acute tubular necrosis; tubulointerstitial nephritis