title: Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions.
abstract: Deltamethrin (DLM) being a potent immunotoxicant affects both humoral and cell mediated immunity. Thus, for the amelioration of its effects, two different bioactive herbal extracts piperine and curcumin are evaluated and their efficacy has been compared. The docking results demonstrated that curcumin has good binding affinity towards CD28 and CD45 receptors as compared to piperine but in vitro studies revealed that piperine is more effective. DLM induced apoptotic markers such as oxidative stress and caspase 3 have been attenuated more significantly by piperine as compared to curcumin. Phenotypic and cytokine changes have also been mitigated best with piperine. Thus, these findings strongly demonstrate that piperine displays the more anti-oxidative, anti-apoptotic and chemo-protective properties in the DLM induced splenic apoptosis as compared to curcumin. So, piperine can be considered the drug of choice under immunocompromised conditions.
authors: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi -835215, Jharkhand, India.
authors: Anoop
authors: A
authors: Kumar
authors: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi -835215, Jharkhand, India. Electronic address: nsharmabit@gmail.com.
authors: Neelima
authors: N
authors: Sharma
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D052117:Benzodioxoles / Q000494:pharmacology*; D018106:CD28 Antigens / Q000235:genetics / Q000276:immunology; D003474:Curcumin / Q000494:pharmacology*; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D017493:Leukocyte Common Antigens / Q000235:genetics / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009570:Nitriles / Q000633:toxicity*; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000494:pharmacology*; D011722:Pyrethrins / Q000633:toxicity*; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D018106:CD28 Antigens; D009570:Nitriles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011722:Pyrethrins; C017180:decamethrin; D017493:Leukocyte Common Antigens; D003474:Curcumin; C008922:piperine
keywords: Apoptosis; Curcumin; Deltamethrin; Oxidative stress; Phenotyping; Piperine