title: Association between polymorphism of β3-adrenoceptor gene and overactive bladder: a meta-analysis.
abstract: Genetic variations in the human β3-adrenoceptor (β3-AR) gene are known to be involved in insufficient relaxation of the bladder muscle during urine storage. The Trp64Arg polymorphism in the β3-AR gene has been found to be an important regulator of the development of overactive bladder (OAB). However, the association between this polymorphism and OAB remains controversial. Therefore, we conducted a meta-analysis to explore the association between the Trp64Arg polymorphism and OAB risk. We examined 2 case-control studies, including a total of 149 OAB cases and 270 healthy controls. The meta-analysis results showed that the Arg allele of the β3-AR gene is positively associated with OAB susceptibility, while Arg allele carriers (Trp64Arg + Arg64Arg) showed positive associations with OAB. These results also demonstrated that the Trp64Arg polymorphism in the β3-AR gene is involved in the pathogenesis of OAB.
authors: Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors: H C
authors: HC
authors: Qu
authors: Department of Orthodontics, The Dental Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors: W
authors: W
authors: Zhang
authors: Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors: Y L
authors: YL
authors: Liu
authors: Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China cmu4h_wangping@126.com.
authors: P
authors: P
authors: Wang
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D053201:Urinary Bladder, Overactive / Q000235:genetics*
chemical_list: D022702:Receptors, Adrenergic, beta-3