title: A case of β-catenin-positive hepatocellular adenoma with MR imaging sign of diffuse intratumoral fat deposition.
abstract: Hepatocellular adenoma (HCA) is a rare primary benign tumor of the liver, which occurs predominantly in young and middle-aged women. Recently, the subclassification of HCA was proposed by the Bordeaux group. Subsequently, characteristic radiological and clinical features have been revealed in each HCA subtype. According to the previous literature, diffuse intratumoral fat deposition is a very common finding in hepatocyte nuclear factor 1α-negative HCA, but this finding has been reported in β-catenin-positive HCA in the literature for only one case. In this case report, we report the second case of β-catenin-positive HCA with MR imaging sign of diffuse intratumoral fat deposition, confirmed immunohistologically on the basis of a surgical specimen. In addition, our case showed hypovascularity and isointensity on the hepatobiliary phase which have been reported as characteristic findings in β-catenin-positive HCA. Diffuse intratumoral fat deposition can be observed in β-catenin-positive HCA, which has a greater probability of malignant transformation than other types of HCA.
authors: Department of Radiology, NTT Medical Center Tokyo, 5-9-22 Higashigotanda, Shinagawa-ku, Tokyo, 141-0022, Japan, masayaishii-tky@umin.ac.jp.
authors: Masaya
authors: M
authors: Ishii
authors: Junichi
authors: J
authors: Kazaoka
authors: Junichi
authors: J
authors: Fukushima
authors: Mariko
authors: M
authors: Gunji
authors: Toru
authors: T
authors: Aoyama
authors: Toshio
authors: T
authors: Fukusato
authors: Keiji
authors: K
authors: Sano
authors: Fukuo
authors: F
authors: Kondo
authors: Toru
authors: T
authors: Takeshita
authors: Shigeru
authors: S
authors: Furui
authors: Masaaki
authors: M
authors: Akahane
mesh_terms: D018248:Adenoma, Liver Cell / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D003287:Contrast Media; D003937:Diagnosis, Differential; D019786:Gadolinium DTPA; D006801:Humans; D033162:Incidental Findings; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D011856:Radiographic Image Enhancement; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D003287:Contrast Media; D051176:beta Catenin; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA