title: Prognostic significance of autocrine motility factor receptor expression by colorectal cancer and lymph node metastases.
abstract: BACKGROUND
  Autocrine motility factor receptor (AMFR) has been linked to metastasis and tumorigenicity. The aim of this study was to evaluate expression and prognostic significance of AMFR in colorectal carcinoma.
  
  
  METHODS
  AMFR expression was evaluated in 127 colon cancer specimens, 131 rectal cancer specimens, and 47 colonic and 25 rectal corresponding lymph node metastases. Clinicopathological correlates of prognostic significance were established by univariate and multivariate analysis. Spearman's correlation determined the association of expression between cancers and their metastases.
  
  
  RESULTS
  AMFR was over-expressed by 22% of colon cancers and 18% of rectal cancers. AMFR over-expression correlated significantly with improved disease-free survival (DFS) (P < .05) in colon cancer and decreased DFS in corresponding nodal metastases. In rectal cancer, AMFR over-expression significantly correlated with decreased overall survival, DFS, and disease-specific survival (P < .001, P = .031, P = .005, respectively) and decreased overall survival in corresponding metastases.
  
  
  CONCLUSIONS
  AMFR may serve as a molecular prognosticator for colon cancer and rectal cancer.
authors: Department of Surgery, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Yasmin
authors: Y
authors: Halwani
authors: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Liliana D
authors: LD
authors: Kojic
authors: Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Simon K
authors: SK
authors: Chan
authors: Department of Surgery, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Terry P
authors: TP
authors: Phang
authors: Department of Pathology and Laboratory Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Hamid
authors: H
authors: Masoudi
authors: Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Steven J M
authors: SJ
authors: Jones
authors: Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Ivan R
authors: IR
authors: Nabi
authors: Department of Surgery, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: smwiseman@providencehealth.bc.ca.
authors: Sam M
authors: SM
authors: Wiseman
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis; D015153:Blotting, Western; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000556:secondary; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D060285:Receptors, Autocrine Motility Factor / Q000096:biosynthesis*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; C555000:AMFR protein, human; D060285:Receptors, Autocrine Motility Factor
keywords: Autocrine motility factor receptor; Colon cancer; Rectal cancer; Tissue microarray