title: CD14+ follicular dendritic cells in lymphoid follicles may play a role in the pathogenesis of IgG4-related disease.
abstract: Proliferated IgG4(+) plasma cells are polyclonal, suggesting that the pathogenesis of IgG4-related disease (IgG4-RD) involves upstream events related to the regulation of IgG4 expansion. We hypothesized that lymphoid follicle formation may play an important role in the pathogenesis of IgG4-RD. Using various antibodies, especially against monocyte, macrophage, and follicular dendritic cell markers, we immunohistochemically assessed the distribution of immune cells in lymphoid follicles. Pathological findings of tissue samples from patients with IgG4-RD (n = 22), reactive hyperplasia (n = 3), multicentric Castleman's disease (n = 3), and Sjögren's syndrome (n = 13) were analyzed. CD14-positive lymphoid follicles were observed only in patients with IgG4-RD, and CD14-positive cells were identified as follicular dendritic cells by multicolor immunohistochemistry. There were few differences in the distributions of other cell types between the IgG4-RD and control groups. The presence of CD14(+) follicular dendritic cells in lymphoid follicles may play a pathophysiological role in IgG4-RD.
authors: Department of Hematology and Immunology, Kanazawa Medical University.
authors: Tomomi
authors: T
authors: Satoh-Nakamura
authors: Nozomu
authors: N
authors: Kurose
authors: Takafumi
authors: T
authors: Kawanami
authors: Takuji
authors: T
authors: Nakamura
authors: Haruka
authors: H
authors: Iwao-Kawanami
authors: Akio
authors: A
authors: Nakajima
authors: Miyuki
authors: M
authors: Miki
authors: Tomoyuki
authors: T
authors: Sakai
authors: Yoshimasa
authors: Y
authors: Fujita
authors: Masao
authors: M
authors: Tanaka
authors: Toshihiro
authors: T
authors: Fukushima
authors: Yasufumi
authors: Y
authors: Masaki
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D020566:Dendritic Cells, Follicular / Q000502:physiology*; D005260:Female; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000378:metabolism*; D008206:Lymphatic Diseases / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D018950:Lipopolysaccharide Receptors