title: Low frequency of mutations in Chinese with acute myeloid leukemia: Different disease or different aetiology?
abstract: Mutations in FLT3, DNMT3A, NRAS, NF1 and TP53 occur in persons of predominately European descent with acute myeloid leukemia (AML). Some, such as internal tandem duplication of FLT3 (FLT3-ITD) and point mutations in DNMT3A and NRAS, are especially frequent whereas others such as NF1 and TP53 are less so. Frequencies of these mutations in persons with seemingly similar AML from other genetic groups are largely unknown. We studied 269 Chinese (mostly Han) with de novo AML. FLT3-ITD was detected in 51 subjects (23%; 95% CI, 17-28%), R882 mutation of DNMT3A in 17 (6%; 95% CI, 3-9%) and NRAS mutation in 17 (7%; 95% CI, 3-9%). No mutations in NF1 and only 1 mutation in TP53 (1%, 95% CI, <2.5%) were detected. Except for FLT3-ITD, frequencies of these mutations are significantly less than those in persons of predominately European descent with AML. The reason(s) for this disparity is unknown but may offer clues to the aetiology of AML in different populations or may indicate some mutations associated with AML in persons of predominately European descent are not fundamental to the aetiology of the disease.
authors: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province 215123, PR China.
authors: Jiawei
authors: J
authors: Yin
authors: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province 215123, PR China.
authors: Xiaoli
authors: X
authors: Xie
authors: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province 215123, PR China.
authors: Fan
authors: F
authors: Zhang
authors: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province 215123, PR China.
authors: Zheng
authors: Z
authors: Chen
authors: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province 215123, PR China.
authors: Chenxi
authors: C
authors: Hu
authors: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province 215123, PR China.
authors: Guangsong
authors: G
authors: Su
authors: The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu Province 215006, PR China.
authors: Hong
authors: H
authors: Liu
authors: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province 215123, PR China.
authors: Yanwen
authors: Y
authors: Zheng
authors: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province 215123, PR China.
authors: Chao
authors: C
authors: He
authors: The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu Province 215006, PR China.
authors: Hongjie
authors: H
authors: Shen
authors: The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu Province 215006, PR China.
authors: Qiaocheng
authors: Q
authors: Qiu
authors: The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu Province 215006, PR China.
authors: Jun
authors: J
authors: He
authors: Suzhou Blood Center, Jiangsu Province 215006, PR China.
authors: Zhirong
authors: Z
authors: Pan
authors: Haematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London SW7 2AZ, UK.
authors: Robert Peter
authors: RP
authors: Gale
authors: The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu Province 215006, PR China.
authors: Depei
authors: D
authors: Wu
authors: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou, Jiangsu Province 215123, PR China; Thrombosis and Hemostasis Key Lab of the Ministry of Health, Soochow University, Suzhou, Jiangsu Province 215006, PR China; Collaborative Innovation Center of Hematology, Soochow University, PR China. Electronic address: yinbin@hotmail.com.
authors: Bin
authors: B
authors: Yin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000208:ethnology / Q000209:etiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation; D059645:Mutation Rate; D009363:Neoplasm Proteins / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D009363:Neoplasm Proteins
keywords: Acute myeloid leukemia; Chinese; Ethnicity; Mutation