title: Membrane bound O-acyltransferases and their inhibitors.
abstract: Since the identification of the membrane-bound O-acyltransferase (MBOATs) protein family in the early 2000s, three distinct members [porcupine (PORCN), hedgehog (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides. In this review, topology determination, development of assays to measure enzymatic activities and discovery of small molecule inhibitors are compared and discussed for each of these enzymes.
authors: *Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K.
authors: Naoko
authors: N
authors: Masumoto
authors: *Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K.
authors: Thomas
authors: T
authors: Lanyon-Hogg
authors: ‡Molecular Medicine Section, National Lung & Heart Institute, Sir Alexander Fleming Building, South Kensington Campus, Imperial College London, SW7 2AZ, U.K.
authors: Ursula R
authors: UR
authors: Rodgers
authors: ‡Molecular Medicine Section, National Lung & Heart Institute, Sir Alexander Fleming Building, South Kensington Campus, Imperial College London, SW7 2AZ, U.K.
authors: Antonios D
authors: AD
authors: Konitsiotis
authors: †Institute of Chemical Biology, Department of Chemistry, Imperial College London, SW7 2AZ, U.K.
authors: Anthony I
authors: AI
authors: Magee
authors: *Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K.
authors: Edward W
authors: EW
authors: Tate
mesh_terms: D000215:Acylation / Q000235:genetics; D000217:Acyltransferases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism; D054439:Ghrelin / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D054878:Lipoylation / Q000235:genetics; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000494:pharmacology
chemical_list: D054439:Ghrelin; D008565:Membrane Proteins; D054852:Small Molecule Libraries; D000217:Acyltransferases; C105599:HHAT protein, human; C491188:PORCN protein, human