title: Sulfasalazine disposition in a subject with 376C>T (nonsense mutation) and 421C>A variants in the ABCG2 gene.
authors: Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors: Keisuke
authors: K
authors: Gotanda
authors: Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors: Tomoko
authors: T
authors: Tokumoto
authors: Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors: Takeshi
authors: T
authors: Hirota
authors: Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors: Masato
authors: M
authors: Fukae
authors: Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors: Ichiro
authors: I
authors: Ieiri
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis / Q000235:genetics*; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics; D001682:Biological Availability; D002462:Cell Membrane / Q000378:metabolism; D018389:Codon, Nonsense / Q000235:genetics*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012460:Sulfasalazine / Q000097:blood / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D000890:Anti-Infective Agents; D018389:Codon, Nonsense; D009363:Neoplasm Proteins; D012460:Sulfasalazine
keywords: ABCG2; breast cancer resistance protein; genetic polymorphism; pharmacokinetics; sulfasalazine