title: β-glucan affects mucosal immunity in children with chronic respiratory problems under physical stress: clinical trials.
abstract: BACKGROUND
  The role of β-glucan in children with respiratory problems is getting more and more attention. In this report we focused on the effects of 30 days oral supplementation with β-glucan on physical activity and immune status of children with respiratory problems.
  
  
  METHODS
  We measured the level of sIgA, eNO and physical activity [using a 6-minute walking test (6MWT)] in 77 children and evaluated the effect of 100 mg/day oral dose.
  
  
  RESULTS
  We found a significant difference between males and females in physical endurance. In the glucan group, the positive effects of glucan were significant in both age groups. In the glucan group, we found significant decrease of eNO levels and stabilization of the sIgA levels.
  
  
  CONCLUSIONS
  Short-term oral application of natural immunomodulator β-glucan stimulated physical endurance in children with respiratory problems and, via stabilization of the sIgA levels, helps their mucosal immunity.
authors: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 Department of Pathology, University of Louisville, Louisville, KY 40202, USA.
authors: Josef
authors: J
authors: Richter
authors: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 Department of Pathology, University of Louisville, Louisville, KY 40202, USA.
authors: Vladimir
authors: V
authors: Svozil
authors: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 Department of Pathology, University of Louisville, Louisville, KY 40202, USA.
authors: Vlastimil
authors: V
authors: Král
authors: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 Department of Pathology, University of Louisville, Louisville, KY 40202, USA.
authors: Lucie
authors: L
authors: Rajnohová Dobiášová
authors: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 Department of Pathology, University of Louisville, Louisville, KY 40202, USA.
authors: Vaclav
authors: V
authors: Vetvicka
keywords: Glucan; IgA; children, saliva; physical activity