title: Efficacy-oriented compatibility for component-based Chinese medicine.
abstract: Single-target drugs have not achieved satisfactory therapeutic effects for complex diseases involving multiple factors. Instead, innovations in recent drug research and development have revealed the emergence of compound drugs, such as cocktail therapies and "polypills", as the frontier in new drug development. A traditional Chinese medicine (TCM) prescription that is usually composed of several medicinal herbs can serve a typical representative of compound medicines. Although the traditional compatibility theory of TCM cannot be well expressed using modern scientific language nowadays, the fundamental purpose of TCM compatibility can be understood as promoting efficacy and reducing toxicity. This paper introduces the theory and methods of efficacy-oriented compatibility for developing component-based Chinese medicines.
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors: Jun-hua
authors: JH
authors: Zhang
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors: Yan
authors: Y
authors: Zhu
authors: Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China.
authors: Xiao-hui
authors: XH
authors: Fan
authors: 1] Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China [2] Chinese Academy of Chinese Medical Science, Beijing 100700, China.
authors: Bo-li
authors: BL
authors: Zhang
mesh_terms: D019295:Computational Biology / Q000379:methods*; D057225:Data Mining; D016208:Databases, Factual; D004338:Drug Combinations; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D057166:High-Throughput Screening Assays; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D058990:Molecular Targeted Therapy; D018579:Patient Selection; D010641:Phenotype; D049490:Systems Biology; D018511:Systems Integration; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal