title: The utility of iron chelators in the management of inflammatory disorders.
abstract: Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. Under pathological conditions with reduced or increased baseline iron levels different consequences regarding protection or susceptibility to inflammation have to be considered. Given the role of iron in development of inflammatory diseases, pharmaceutical agents targeting this pathway promise to improve the clinical outcome. The objective of this review is to highlight the mechanisms of iron regulation and iron chelation, and to demonstrate the potential impact of this strategy in the management of several acute and chronic inflammatory diseases, including cancer.
authors: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, Canada B3H 1X5 ; Department of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
authors: C
authors: C
authors: Lehmann
authors: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Pharmacy, East West University, Plot No. A/2, Jahurul Islam City, Aftabnagar, Dhaka 1219, Bangladesh.
authors: S
authors: S
authors: Islam
authors: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
authors: S
authors: S
authors: Jarosch
authors: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, Canada B3H 1X5.
authors: J
authors: J
authors: Zhou
authors: Department of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, Canada B3H 1X5 ; Department of Pathology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
authors: D
authors: D
authors: Hoskin
authors: Department of Pathology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
authors: A
authors: A
authors: Greenshields
authors: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
authors: N
authors: N
authors: Al-Banna
authors: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Physiology, Faculty of Medicine, Cairo University, 1 Al-Saray St., Cairo 11559, Egypt.
authors: N
authors: N
authors: Sharawy
authors: Department of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
authors: A
authors: A
authors: Sczcesniak
authors: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
authors: M
authors: M
authors: Kelly
authors: Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
authors: K
authors: K
authors: Wafa
authors: Chelation Partners Inc., 1411 Oxford St., Halifax, NS, Canada B3H 3Z1.
authors: W
authors: W
authors: Cheliak
authors: Chelation Partners Inc., 1411 Oxford St., Halifax, NS, Canada B3H 3Z1.
authors: B
authors: B
authors: Holbein
mesh_terms: D000818:Animals; D005355:Fibrosis; D006432:Hemochromatosis / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy; D017382:Reactive Oxygen Species / Q000378:metabolism; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy
chemical_list: D007502:Iron Chelating Agents; D017382:Reactive Oxygen Species; D007501:Iron