title: Conformal radiotherapy for locally advanced juvenile nasopharyngeal angio-fibroma.
abstract: OBJECTIVE
  To assess the efficacy of radiation in the treatment of juvenile nasopharyngeal angiofibroma (JNA).
  
  
  METHODS
  Data were retrieved for JNA treated with radiotherapy from 1987-2012. The demographics, treatment and outcome data were recorded in predesigned proforma.
  
  
  RESULTS
  Data of 32 patients were retrieved. Median age was 17 years (range: 12-33 years). All patients received radiation because of refractory, residual or unresectable locally advanced disease. All patients were planned with a three-dimensional conformal technique (3DCRT). The median radiation dose was 30 Gray (range: 30-45 Gray). Median follow-up was 129 months (range: 1-276 months). At the last follow-up, 13 patients were found to have a radiological complete response. Two patients progressed 38 and 43 months after completion of treatment and opted for alternative treatment. One patient developed squamous cell carcinoma of the nasal ale 15 years after radiation.
  
  
  CONCLUSIONS
  Conformal radiotherapy shows promise as an alternative treatment approach for locally advanced JNA and confers long-term disease control with minimal toxicity.
authors: Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
authors: Supriya
authors: S
authors: Mallick
authors: Rony
authors: R
authors: Benson
authors: Suman
authors: S
authors: Bhasker
authors: Bidhu Kalyan
authors: BK
authors: Mohanti
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D018322:Angiofibroma / Q000473:pathology* / Q000532:radiotherapy*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult