title: Multiple sclerosis in two patients with coexisting Wilson's disease.
abstract: Wilson's disease (WD) is an inherited disorder of copper metabolism with main hepatic and neurological symptoms. Multiple sclerosis (MS) is an autoimmune and inflammatory demyelinating disease. We present two patients with coexisting WD and MS. In both cases the diagnosis of MS preceded diagnosis of WD. Both patients exhibited neurological signs typical of MS (internuclear palsy, optic neuritis). The first one displayed typical signs of WD (hypomimia, sialorrhea, behavioral changes). The second patient had liver injury without any neurological symptoms. In both cases clinical course of MS was very mild (17 and 12 years of observation) which may be caused by immunosuppressive effect of free copper.
authors: 2nd Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, 02 957 Warsaw, Poland. Electronic address: kdziezyc@op.pl.
authors: Karolina
authors: K
authors: Dzieżyc
authors: 2nd Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, 02 957 Warsaw, Poland. Electronic address: tomlit@medprakt.pl.
authors: Tomasz
authors: T
authors: Litwin
authors: 2nd Department of Neurology, Institute of Psychiatry and Neurology, Sobieskiego 9, 02 957 Warsaw, Poland; Department of Clinical and Experimental Pharmacology, Medical University of Warsaw, Poland. Electronic address: czlonkow@ipin.edu.pl.
authors: Anna
authors: A
authors: Członkowska
keywords: Coexistence; D-penicillamine; Free copper; Multiple sclerosis; Wilson's disease; Zinc sulfate