title: Concise total synthesis of (±)-aspidospermidine.
abstract: (±)-Aspidospermidine (1) has been synthesized from the commercially available 2,3-dihydro-1H-carbazol-4(9H)-one 6 in 10 steps with 20% overall yield. The key step of the strategy is a one-pot carbonyl reduction/iminium formation/intramolecular conjugate addition reaction that may be applied for the synthesis of other Aspidosperma alkaloids.
authors: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, People's Republic of China. shexg@lzu.edu.cn.
authors: Haichen
authors: H
authors: Ma
authors: Xingang
authors: X
authors: Xie
authors: Peng
authors: P
authors: Jing
authors: Weiwei
authors: W
authors: Zhang
authors: Xuegong
authors: X
authors: She
mesh_terms: D066241:Carbon-13 Magnetic Resonance Spectroscopy; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D066244:Proton Magnetic Resonance Spectroscopy; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
chemical_list: D026121:Indole Alkaloids; D011804:Quinolines; C409672:aspidospermidine