title: The role of immunohistochemical tests in multimodal treatment of the aggressive forms of breast cancer.
abstract: Aggressive breast cancer is an invasive form with a differentiation degree G3/G4, the absence of estrogen receptor and progesterone and the absence or presence of the gene HER 2(+ or 3+). The immunohistochemical tests have an important role in establishing the diagnosis and the therapy.
  
  
  METHODS
  It was shown that the aggressive breast cancers, 97 out of 316 cases were operated in the period October 2011 - February 2014. The criteria of inclusion/ exclusion in the study groups and the treatment schemes were exposed.
  
  
  RESULTS
  For the study group (group A=43/ group B=45/ group C=9 cases), the distribution according to the age group and immunohistochemical classification, were shown and, histologically, the type of surgical intervention, postoperative staging, postoperative complications were highlighted.
  
  
  CONCLUSIONS
  The treatment of the aggressive forms of breast cancer, neoadjuvant and adjuvant can both be set only by IHC tests.
authors: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors: D
authors: D
authors: Mihai
authors: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors: S
authors: S
authors: Voiculescu
authors: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors: C
authors: C
authors: Dimitriu
authors: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors: F
authors: F
authors: Constantinescu
authors: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors: S
authors: S
authors: Stanilescu
authors: Surgery Clinic, "Coltea" Hospital, Bucharest.
authors: T
authors: T
authors: Burcos
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
keywords: HER2; cathepsin D; invasive form; progesterone; receptors for estrogen