title: Bevacizumab and postoperative wound complications in patients with liver metastases of colorectal cancer.
abstract: OBJECTIVE
  The present study investigated whether bevacizumab (BV) is associated with postoperative wound complications (PWCs).
  
  
  METHODS
  We retrospectively analyzed patients undergoing surgery for liver metastases of colorectal cancer at our Institution. Patients were divided into 3 groups according to the preoperative treatment: che mo therapy with BV (group A), chemotherapy without BV (group B) and no chemotherapy (group C).
  
  
  RESULTS
  Between February 2003 and September 2012, 297 patients underwent 373 surgeries. Groups A, B and C consisted of 23, 62 and 288 patients, respectively. PWCs occurred in 29 patients (7.8%). In multivariate analysis, there were no differences in PWCs among the groups (C vs. B:P=0.739; C vs. A: P=0.110). Conversely, lower serum albumin levels (<3.5 g/dl vs. ≥ 3.5 g/dl: p=0.030) and synchronous colorectal resection (no vs. yes; p<0.001) remained significant risk factors of developing PWCs.
  
  
  CONCLUSIONS
  Chemotherapy with or without BV did not influence the risk of PWCs.
authors: Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Hirofumi
authors: H
authors: Utsumi
authors: Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan yohonma@ncc.go.jp.
authors: Yoshitaka
authors: Y
authors: Honma
authors: Clinical Research Center, Chiba University Hospital, Chiba, Japan.
authors: Kengo
authors: K
authors: Nagashima
authors: Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Satoru
authors: S
authors: Iwasa
authors: Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Atsuo
authors: A
authors: Takashima
authors: Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Ken
authors: K
authors: Kato
authors: Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Tetsuya
authors: T
authors: Hamaguchi
authors: Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Yasuhide
authors: Y
authors: Yamada
authors: Gastrointestinal Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Yasuhiro
authors: Y
authors: Shimada
authors: Hepato-Biliary-Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Yoji
authors: Y
authors: Kishi
authors: Hepato-Biliary-Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Satoshi
authors: S
authors: Nara
authors: Hepato-Biliary-Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Minoru
authors: M
authors: Esaki
authors: Hepato-Biliary-Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan.
authors: Kazuaki
authors: K
authors: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage* / Q000009:adverse effects; D000068258:Bevacizumab; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects; D011183:Postoperative Complications / Q000139:chemically induced / Q000473:pathology*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D005472:Fluorouracil
keywords: Bevacizumab; liver metastases of colorectal cancer; postoperative wound complications