title: Relationship between adipoq gene polymorphism and lipid levels and diabetes.
abstract: Metabolic syndrome (MS), a series of physiological and metabolic disorders caused by insulin resistance, combines clinical syndrome of abdominal obesity, diabetes or impaired glucose regulation, dyslipidemia, hypertension and other metabolic diseases. Several studies have found that multiple single nucleotide polymorphism (SNP) exists in adiponectin gene (ADIPOQ) and some unusual mutations might be related to hypoadiponectinemia and MS. This study aims to explore the relationship between ADIPOQ gene polymorphism and lipid levels and diabetes. A total of 1,049 confirmed MS cases were selected for research. From the perspective of potential functional SNPs of ADIPOQ gene, tag SNPs, combined with environmental factors, we studied the relationship between ADIPOQ gene polymorphism and phenotype (serum adiponectin level) and further analyzed the correlation of ADIPOQ gene polymorphism and metabolic syndrome components so as to clear the relationship between ADIPOQ gene polymorphism and lipid levels and diabetes and at the same time provide a scientific basis for preventing primarily MS etiology and screening high-risk groups.
authors: Department of Clinical Laboratory, the PLA General Hospital, Beijing, China.
authors: Y
authors: Y
authors: Sun
authors: Clinical Laboratory Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
authors: D G
authors: DG
authors: Li
authors: Department of Clinical Laboratory Medicine, The Fifth Peoples Hospital of Chengdu, Chengdu, China.
authors: Q
authors: Q
authors: Li
authors: Department of Clinical Laboratory Medicine, The Fifth Peoples Hospital of Chengdu, Chengdu, China.
authors: L
authors: L
authors: Huang
authors: Beijing Center for Physical and Chemical Analysis, Beijing, China.
authors: Z
authors: Z
authors: He
authors: Department of Clinical Laboratory, the PLA General Hospital, Beijing, China.
authors: F
authors: F
authors: Zhang
authors: Department of Clinical Laboratory, the PLA General Hospital, Beijing, China.
authors: C B
authors: CB
authors: Wang
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood / Q000235:genetics
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D014280:Triglycerides