title: [Molecular mechanisms of angioimmunoblastic T-cell lymphoma].
abstract: Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma. The origins of AITL tumor cells were thought to be follicular helper T (TFH) cells based on the common features of these two cell types. Recent findings suggest a multistep model for the development of AITL. The immature blood cells evolve into premalignant (prelymphoma) cells by acquisition of premalignant mutations including TET2 and/or DNMT3A mutations. The premalignant cells finally develop into full-blown tumor cells by accumulation of tumor-specific RHOA mutations. Combinations of premalignant and tumor-specific mutations may induce development of AITL.
authors: Department of Hematology, Faculty of Medicine, University of Tsukuba.
authors: Mamiko
authors: M
authors: Sakata-Yanagimoto
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000276:immunology*; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D009154:Mutation / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins