title: Clinical significance of CD155 expression in human pancreatic cancer.
abstract: OBJECTIVE
  CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer.
  
  
  METHODS
  We investigated CD155 expression in 134 patients with pancreatic cancer, and evaluated the correlations of CD155 with prognosis, tumor immunity and angiogenesis. Furthermore, CD155 functions were examined.
  
  
  RESULTS
  CD155 expression was abundant in pancreatic cancer tissues. Patients with high CD155 expression had poorer postoperative prognosis than those with low expression. Multivariate analysis indicated that CD155 expression had a significant independent prognostic value. Tumor CD155 expression inversely correlated with the presence of tumor-infiltrating lymphocytes. Furthermore, it significantly positively correlated with vascular endothelial growth factor expression and intra tumoral microvessel density. In addition, silencing of CD155 inhibited proliferation, and induced cell-cycle arrest at G2/M phase in pancreatic cancer cells.
  
  
  CONCLUSIONS
  CD155 may play a critical role through both immunological and non-immuno logical mechanisms in pancreatic cancer and may be a therapeutic target for this intractable malignancy.
authors: Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
authors: Satoshi
authors: S
authors: Nishiwada
authors: Department of Surgery, Nara Medical University, Kashihara, Nara, Japan m-sho@naramed-u.ac.jp.
authors: Masayuki
authors: M
authors: Sho
authors: Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
authors: Satoshi
authors: S
authors: Yasuda
authors: Department of Pathology, Nara Medical University, Kashihara, Nara, Japan.
authors: Keiji
authors: K
authors: Shimada
authors: Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
authors: Ichiro
authors: I
authors: Yamato
authors: Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
authors: Takahiro
authors: T
authors: Akahori
authors: Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
authors: Shoichi
authors: S
authors: Kinoshita
authors: Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
authors: Minako
authors: M
authors: Nagai
authors: Department of Pathology, Nara Medical University, Kashihara, Nara, Japan.
authors: Noboru
authors: N
authors: Konishi
authors: Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
authors: Yoshiyuki
authors: Y
authors: Nakajima
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000276:immunology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000235:genetics* / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D011991:Receptors, Virus / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D011991:Receptors, Virus; D042461:Vascular Endothelial Growth Factor A; C066100:poliovirus receptor
keywords: CD155; angiogenesis; pancreatic cancer; prognostic factor; tumor immunity