title: Levels of F2 isoprostane in Behcet's disease: Correlation with cardiometabolic risk factors.
abstract: OBJECTIVE
  Behcet's disease (BD) is a chronic inflammatory disease and recent findings suggest a role of oxidative stress in the pathogenesis of BD. Free radical-induced oxidative stress is also involved in the pathogenesis of cardiovascular and other rheumatic diseases. Oxidative stress may be detected in vivo by measuring F2 isoprostanes. Here, we measured plasma levels of F2 isoprostane in patients with BD and evaluated the correlation of F2 isoprostane with cardiometabolic risk factors.
  
  
  METHODS
  Forty-three patients with BD in remission and 37 age- and sex-matched controls were recruited for the study. Blood samples were obtained to determine F2 isoprostane, C-reactive protein levels, erythrocyte sedimentation rate, and other biochemical parameters. Homeostasis model assessment insulin resistance and body mass index were calculated. Systolic blood pressure, diastolic blood pressure, and waist circumference were measured.
  
  
  RESULTS
  Plasma F2 isoprostane, fasting plasma glucose, triglyceride, and C-reactive protein levels were significantly higher in patients with BD compared with healthy controls, whereas high-density lipoprotein cholesterol levels were significantly lower in patients with BD. F2 isoprostane levels did not correlate with cardiometabolic risk factors, C-reactive protein levels, or erythrocyte sedimentation rate.
  
  
  CONCLUSIONS
  High levels of F2 isoprostane in patients with BD indicate oxidative stress. Antioxidant therapeutic approaches could potentially affect the course of this disease.
authors: Gul
authors: G
authors: Sagun
authors: Aytekin
authors: A
authors: Oguz
authors: Banu
authors: B
authors: Mesci
authors: Banu
authors: B
authors: Isbilen
authors: Mukaddes
authors: M
authors: Kavala
authors: Havva
authors: H
authors: Keskin
authors: Mumtaz
authors: M
authors: Takir
authors: Sibel Zehra
authors: SZ
authors: Aydin
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D028441:F2-Isoprostanes / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D028441:F2-Isoprostanes; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002097:C-Reactive Protein
keywords: Behcet's disease; Cardiometabolic risk factors; F2 isoprostane