title: Aberrant high frequency oscillations recorded in the rat nucleus accumbens in the methylazoxymethanol acetate neurodevelopmental model of schizophrenia.
abstract: BACKGROUND
  Altered activity of the nucleus accumbens (NAc) is thought to be a core feature of schizophrenia and animal models of the disease. Abnormal high frequency oscillations (HFO) in the rat NAc have been associated with pharmacological models of schizophrenia, in particular the N-methyl-d-aspartate receptor (NMDAR) hypofunction model. Here, we tested the hypothesis that abnormal HFO are also associated with a neurodevelopmental rat model.
  
  
  METHODS
  Using prenatal administration of the mitotoxin methylazoxymethanol acetate (MAM) we obtained the offspring MAM rats. Adult MAM and Sham rats were implanted with electrodes, for local field potential recordings, in the NAc.
  
  
  RESULTS
  Spontaneous HFO (spHFO) in MAM rats were characterized by increased power and frequency relative to Sham rats. MK801 dose-dependently increased the power of HFO in both groups. However, the dose-dependent increase in HFO frequency found in Sham rats was occluded in MAM rats. The antipsychotic compound, clozapine reduced the frequency of HFO which was similar in both MAM and Sham rats. Further, HFO were modulated in a similar manner by delta oscillations in both MAM and Sham rats.
  
  
  CONCLUSIONS
  Together these findings suggest that increased HFO frequency represents an important feature in certain animal models of schizophrenia. These findings support the hypothesis that altered functioning of the NAc is a core feature in animal models of schizophrenia.
authors: Laboratory of the Limbic System, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland.
authors: Sailaja A
authors: SA
authors: Goda
authors: Laboratory of the Limbic System, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland.
authors: Maciej
authors: M
authors: Olszewski
authors: Laboratory of the Limbic System, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland.
authors: Joanna
authors: J
authors: Piasecka
authors: Laboratory of the Limbic System, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland.
authors: Karolina
authors: K
authors: Rejniak
authors: The Hull York Medical School, University of York, Heslington, York YO10 5DD, UK.
authors: Miles A
authors: MA
authors: Whittington
authors: Laboratory of the Limbic System, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland.
authors: Stefan
authors: S
authors: Kasicki
authors: Laboratory of the Limbic System, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093 Warsaw, Poland; The Hull York Medical School, University of York, Heslington, York YO10 5DD, UK.
authors: Mark J
authors: MJ
authors: Hunt
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D058256:Brain Waves / Q000187:drug effects / Q000502:physiology*; D003024:Clozapine / Q000494:pharmacology; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D018691:Excitatory Amino Acid Antagonists; D005260:Female; D008297:Male; D008746:Methylazoxymethanol Acetate / Q000633:toxicity*; D009498:Neurotoxins / Q000633:toxicity*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000503:physiopathology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012559:Schizophrenia / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology*
chemical_list: D014150:Antipsychotic Agents; D018691:Excitatory Amino Acid Antagonists; D009498:Neurotoxins; D008746:Methylazoxymethanol Acetate; D016291:Dizocilpine Maleate; D003024:Clozapine
keywords: Clozapine; High frequency oscillations; MAM rat model; NMDAR antagonists; Schizophrenia