title: The potential of chitosan and its derivatives in prevention and treatment of age-related diseases.
abstract: Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, chitooligosaccharides and their derivatives in prevention and treatment of age-related dysfunctions is reviewed and discussed in this paper. The influence of oxidative stress, low density lipoprotein oxidation, increase of tissue stiffness, protein conformational changes, aging-associated chronic inflammation and their pathobiological significance have been considered. The chitosan-based functional food also has been reviewed.
authors: Department of Materials Science and Applied Chemistry, Riga Technical University, Azenes 14/24, Riga, LV-1048, Latvia. garrykerch@inbox.lv.
authors: Garry
authors: G
authors: Kerch
mesh_terms: D000375:Aging; D000818:Animals; D048271:Chitosan / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D002908:Chronic Disease / Q000517:prevention & control* / Q000628:therapy; D019587:Dietary Supplements; D019648:Foods, Specialized; D006801:Humans; D009844:Oligosaccharides / Q000378:metabolism / Q000627:therapeutic use; D018384:Oxidative Stress
chemical_list: D009844:Oligosaccharides; D048271:Chitosan