title: Experimental Myocardial Infarction Upregulates Circulating Fibroblast Growth Factor-23.
abstract: Myocardial infarction (MI) is a major cause of death worldwide. Epidemiological studies have linked vitamin D deficiency to MI incidence. Because fibroblast growth factor-23 (FGF23) is a master regulator of vitamin D hormone production and has been shown to be associated with cardiac hypertrophy per se, we explored the hypothesis that FGF23 may be a previously unrecognized pathophysiological factor causally linked to progression of cardiac dysfunction post-MI. Here, we show that circulating intact Fgf23 was profoundly elevated, whereas serum vitamin D hormone levels were suppressed, after induction of experimental MI in rat and mouse models, independent of changes in serum soluble Klotho or serum parathyroid hormone. Both skeletal and cardiac expression of Fgf23 was increased after MI. Although the molecular link between the cardiac lesion and circulating Fgf23 concentrations remains to be identified, our study has uncovered a novel heart-bone-kidney axis that may have important clinical implications and may inaugurate the new field of cardio-osteology.
authors: University of Veterinary Medicine Vienna, Vienna, Austria.
authors: Olena
authors: O
authors: Andrukhova
authors: University of Veterinary Medicine Vienna, Vienna, Austria.
authors: Svetlana
authors: S
authors: Slavic
authors: University of Veterinary Medicine Vienna, Vienna, Austria.
authors: Kathrin I
authors: KI
authors: Odörfer
authors: University of Veterinary Medicine Vienna, Vienna, Austria.
authors: Reinhold G
authors: RG
authors: Erben
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D005966:Glucuronidase / Q000097:blood; D000090265:Klotho Proteins; D051379:Mice; D009203:Myocardial Infarction / Q000097:blood*; D051381:Rats; D011916:Rats, Inbred F344; D014807:Vitamin D / Q000097:blood*
chemical_list: C000717428:Fgf23 protein, mouse; C505605:Fgf23 protein, rat; D014807:Vitamin D; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins
keywords: FGF23; MYOCARDIAL INFARCTION; VITAMIN D