title: H1N1 pneumonitis associated with long-term non-steroidal anti-inflammatory drug abuse.
abstract: This case series discusses two similar presentations of H1N1 influenza in young patients with a background history of long-term non-steroidal anti-inflammatory drug (NSAID) abuse. Both patients presented with type 1 respiratory failure requiring intensive care unit admission and subsequent organ support. This report reviews the immunosuppressive effects of long-term NSAID use and highlights a potential link to the significant morbidity seen.
authors: Kingston Hospital, London, UK.
authors: Emma
authors: E
authors: Prower
authors: Department of ITU, Kingston Hospital, London, UK.
authors: Ozair
authors: O
authors: Hasnain
authors: Department of ITU, Kingston Hospital, London, UK.
authors: Chris
authors: C
authors: Oscier
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000592:standards; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000139:chemically induced* / Q000276:immunology / Q000821:virology; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000276:immunology / Q000821:virology; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000821:virology; D018746:Systemic Inflammatory Response Syndrome / Q000139:chemically induced / Q000276:immunology / Q000821:virology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal