title: The association between thyroid autoantibodies in serum and abnormal function and structure of the thyroid.
abstract: OBJECTIVE
  To evaluate the association between thyroid autoantibodies and abnormalities in thyroid function and structure, and to investigate any risk factors.
  
  
  METHODS
  A cross-sectional survey was undertaken in Chengdu residents ≥ 18 years with no previous thyroid disease. The study participants provided demographic and clinical data. Thyroid function and serum concentrations of the thyroid autoantibodies antithyroperoxidase antibody (TPOAb) and antithyroglobulin antibody (TgAb) were measured.
  
  
  RESULTS
  A total of 1334 subjects were included in this study. The prevalence of TPOAb and TgAb positivity was significantly higher in female than in male subjects. The prevalence of thyroid autoantibodies in those with subclinical hypothyroidism and clinical hyper- and hypothyroidism was significantly greater than in euthyroid subjects. The concentration of TPOAb and TgAb in subjects with both TPOAb and TgAb was significantly higher than in those who exhibited only one type of thyroid autoantibody. Using multivariate logistic regression analysis, female sex, thyroid volume, thyroid hypo- and heteroechogenicity were found to be risk factors for the presence of autoantibodies.
  
  
  CONCLUSIONS
  Thyroid autoantibodies were common in the general population. Women with thyroid enlargement, hypoechogenicity and heteroechogenicity might benefit from routine screening for thyroid autoantibodies and thyroid function.
authors: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Yue-Rong
authors: YR
authors: Yan
authors: Yulin Community Health Service Centre, Chengdu, Sichuan Province, China.
authors: Xi-Lian
authors: XL
authors: Gao
authors: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Jing
authors: J
authors: Zeng
authors: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China Department of Geriatric Medicine, Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China.
authors: Yang
authors: Y
authors: Liu
authors: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Qing-Guo
authors: QG
authors: Lv
authors: Yulin Community Health Service Centre, Chengdu, Sichuan Province, China.
authors: Jing
authors: J
authors: Jiang
authors: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China sansan1880@126.com.
authors: Hui
authors: H
authors: Huang
authors: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors: Nan-Wei
authors: NW
authors: Tong
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000276:immunology; D007453:Iodide Peroxidase / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D011795:Surveys and Questionnaires; D013954:Thyroglobulin / Q000276:immunology*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology / Q000503:physiopathology*
chemical_list: D001323:Autoantibodies; C006606:anti-thyroglobulin; C056626:thyroid microsomal antibodies; D013954:Thyroglobulin; D007453:Iodide Peroxidase
keywords: Antithyroperoxidase antibody; antithyroglobulin antibody; epidemiology study; risk factors; thyroid autoantibodies; thyroid diseases