title: Age at Epstein-Barr virus infection and Epstein-Barr virus nuclear antigen-1 antibodies in Swedish children.
abstract: There is strong evidence supporting a role for Epstein-Barr virus (EBV) in the etiopathogenesis of multiple sclerosis (MS). Because of the strong association between antibody (Ab) titer against EBV nuclear antigen 1 (EBNA1) and late age at EBV infection, manifested as infectious mononucleosis (IM), and MS risk, we sought to determine whether age at primary EBV infection was associated with subsequent anti-EBNA1 Ab titer in a longitudinal study of Swedish children with EBV seropositivity and anti-EBNA1 Ab titers measured at ages 2, 5, and 10.
authors: Department of Nutrition, Harvard School of Public Health, Boston, MA, USA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: ksimon@hsph.harvard.edu.
authors: K Claire
authors: KC
authors: Simon
authors: Department of Immunology, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
authors: Shanie
authors: S
authors: Saghafian-Hedengren
authors: Department of Immunology, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
authors: Eva
authors: E
authors: Sverremark-Ekström
authors: Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet and Sachs' Children's Hospital, Södersjukhuset, Stockholm, Sweden.
authors: Caroline
authors: C
authors: Nilsson
authors: Department of Nutrition, Harvard School of Public Health, Boston, MA, USA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
authors: Alberto
authors: A
authors: Ascherio
keywords: Anti-EBNA; EBV seroconversion; Epidemiology; Epstein-Barr virus; Infectious mononucleosis; Multiple sclerosis