title: Cognitive and neuropsychiatric disease manifestations in MS.
abstract: Multiple sclerosis is associated with a wide array of behavioral problems. This brief overview begins with a summary of the pathophysiology and treatment of MS. Thereafter, sections are devoted to psychiatric syndromes and cognitive decline linked to MS. The immune basis and brain imaging data associated with these changes are subsequently reviewed. The frequency and severity of these changes in mentation highlight the point that MS patients should, as part of their routine care, have access to psychiatrists, neuropsychologists and allied mental health specialists.
authors: University of Toronto, Department of Psychiatry and Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M5R 3B6. Electronic address: antfeinstein@aol.com.
authors: A
authors: A
authors: Feinstein
authors: Kessler Foundation Research Center, West Orange, New Jersey, USA.
authors: J
authors: J
authors: DeLuca
authors: Department of Psychiatry, University of Adelaide, Adelaide, Australia.
authors: B T
authors: BT
authors: Baune
authors: Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.
authors: M
authors: M
authors: Filippi
authors: Center for Brain Research, Medical University of Vienna, Vienna, Austria.
authors: H
authors: H
authors: Lassman
keywords: Cognition; Depression; MRI; Multiple sclerosis; Neuropathology; Neuropsychiatry