title: Periodontal ligament stem cells: current status, concerns, and future prospects.
abstract: Periodontal ligament stem cells (PDLSCs), which reside in the perivascular space of the periodontium, possess characteristics of mesenchymal stem cells and are a promising tool for periodontal regeneration. Recently, great progress has been made in PDLSC transplantation. Investigators are attempting to maximize the proliferation and differentiation potential of PDLSCs by modifying culture conditions and applying growth factors. Nevertheless, problems remain. First, incomparability among different studies must be minimized by establishing standard guidelines for culture and identification of PDLSCs. Notably, attention should be paid to the biological safety of PDLSC transplantation. The present review updates the latest findings regarding PDLSCs and discusses standard criteria for culture and identification of PDLSCs. Finally, the review calls for careful consideration of PDLSC transplantation safety.
authors: Department of Periodontology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, 56 Ling Yuan Road West, Guangzhou, Guangdong 510055, China ; Guangdong Provincial Key Laboratory of Stomatology, China.
authors: Wenjun
authors: W
authors: Zhu
authors: Department of Periodontology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, 56 Ling Yuan Road West, Guangzhou, Guangdong 510055, China ; Guangdong Provincial Key Laboratory of Stomatology, China.
authors: Min
authors: M
authors: Liang