title: [Glial fibrillary acidic protein: the component of intermediate filaments in the vertebrate brain astrocytes].
abstract: Glial fibrillary acidic protein (GFAP) refers to the type III intermediate filament proteins and is the essential component of the cytoskeleton in astrocytes of all vertebrates. This review presents current data on the molecular organization of GFAP in a comparative aspect. The results of most relevant studies using immunocytochemical labeling of the protein are summarized. The data on the changes in expression of GFAP in Alexander disease caused by the primary pathology of astrocytes are presented.
authors: E G
authors: EG
authors: Sukhorukova
authors: D É
authors: DÉ
authors: Kruzhevskiĭ
authors: O S
authors: OS
authors: Alekseeva
mesh_terms: D038261:Alexander Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D005786:Gene Expression Regulation; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D006801:Humans; D007382:Intermediate Filaments / Q000378:metabolism* / Q000473:pathology
chemical_list: D005904:Glial Fibrillary Acidic Protein