title: Pediatric Pharyngeal IgD-positive Monoclonal Plasmacytoid and Plasma Cell Neoplasm.
abstract: Pediatric neoplasm with monoclonal proliferation of lymphoplasmacytoid lymphocytes and plasma cells is exceedingly rare and has essentially never been reported in immunocompetent children. Here, we report a previously healthy 13-year-old girl with a pharyngeal mass and enlarged cervical lymph nodes. The pharyngeal mass was composed of CD138, CD79a, MUM-1, IgD, CD20, PAX-5, CD43, λ-restricted monoclonal plasmacytoid, and plasma cells. Scattered CD20, PAX-5 B cells were present in the background. The patient was treated as localized non-Hodgkin lymphoma (stage II) with cyclophosphamide, doxorubicin, vincristine, and prednisone and is in complete remission at 17 months from the last chemotherapy.
authors: *Department of Pathology and Laboratory Medicine, Indiana University School of Medicine †Department of Pediatric Hematology and Oncology, Riley Hospital for Children, Indiana University Health, Indianapolis, IN.
authors: Shanxiang
authors: S
authors: Zhang
authors: Catherine
authors: C
authors: Long
mesh_terms: D000293:Adolescent; D000658:Amoxicillin / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D017291:Clarithromycin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007121:Immunocompetence; D007072:Immunoglobulin D / Q000032:analysis*; D064747:Lansoprazole / Q000627:therapeutic use; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis; D010266:Paraproteins / Q000032:analysis*; D010610:Pharyngeal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology*; D000069293:Plasmablastic Lymphoma / Q000175:diagnosis; D011183:Postoperative Complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D014068:Tonsillectomy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D007072:Immunoglobulin D; D010266:Paraproteins; D064747:Lansoprazole; D014750:Vincristine; D004317:Doxorubicin; D000658:Amoxicillin; D003520:Cyclophosphamide; D017291:Clarithromycin; D011241:Prednisone