title: Predictors of subclinical cardiovascular disease in women with polycystic ovary syndrome: interrelationship of dyslipidemia and arterial blood pressure.
abstract: Background. Women with polycystic ovary syndrome (PCOS) could develop subclinical atherosclerosis during life. Purpose. To analyze cardiovascular risk (CVR) factors and their relation to clinical markers of cardiovascular disease (CVD) in respect to their age. Material and Methods. One hundred women with PCOS (26.32 ± 5.26 years, BMI: 24.98 ± 6.38 kg/m(2)) were compared to 50 respective controls. In all subjects, total cholesterol (TC), HDL-C, LDL-C, triglycerides, TC/HDL-C and TG/HDL-C ratios, glucose, insulin and HOMA index, waist-to-hip ratio (WHR), systolic and diastolic blood pressure (SBP and DBP, resp.), and carotid intima-media thickness (CIMT) were analyzed in respect to their age and level of androgens. Results. PCOS over 30 years had higher WHR (P = 0.008), SBP (P < 0.001), DBP (P < 0.001), TC (P = 0.028), HDL-C (P = 0.028), LDL-C (P = 0.045), triglycerides (P < 0.001), TC/HDL-C (P < 0.001), and triglycerides/HDL-C (P < 0.001) and had more prevalent hypertension and pronounced CIMT on common carotid arteries even after adjustment for BMI (P = 0.005 and 0.036, resp.). TC/HDL-C and TG/HDL-C were higher in PCOS with the highest quintile of FAI in comparison to those with lower FAI (P = 0.045 and 0.034, resp.). Conclusions. PCOS women older than 30 years irrespective of BMI have the potential for early atherosclerosis mirrored through the elevated lipids/lipid ratios and through changes in blood pressure.
authors: Clinic of Endocrinology, Diabetes and Diseases of Metabolism, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors: Djuro
authors: D
authors: Macut
authors: General Hospital Pančevo, 26000 Pančevo, Serbia.
authors: Marina
authors: M
authors: Bačević
authors: Clinic of Endocrinology, Diabetes and Diseases of Metabolism, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors: Ivana
authors: I
authors: Božić-Antić
authors: University Medical Center "Bežanijska Kosa", 11080 Belgrade, Serbia.
authors: Jelica
authors: J
authors: Bjekić-Macut
authors: Clinic of Endocrinology, Diabetes and Diseases of Metabolism, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors: Milorad
authors: M
authors: Čivčić
authors: Clinic of Endocrinology, Diabetes and Diseases of Metabolism, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors: Snježana
authors: S
authors: Erceg
authors: Department of Biochemistry, Institute for Biological Research "Siniša Stanković", University of Belgrade, 11060 Belgrade, Serbia.
authors: Danijela
authors: D
authors: Vojnović Milutinović
authors: Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors: Olivera
authors: O
authors: Stanojlović
authors: University Medical Center "Bežanijska Kosa", 11080 Belgrade, Serbia.
authors: Zoran
authors: Z
authors: Andrić
authors: Clinic of Obstetrics and Gynecology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
authors: Biljana
authors: B
authors: Kastratović-Kotlica
authors: Faculty of Mathematics, University of Belgrade, 11000 Belgrade, Serbia.
authors: Tijana
authors: T
authors: Šukilović