title: Anti-Salmonella Activity of Volatile Compounds of Vietnam Coriander.
abstract: Essential oil derived from the fresh leaves of Polygonum odoratum Lour was tested for their effects on a foodborne bacterium Salmonella choleraesuis subsp. choleraesuis ATCC 35640 using a broth dilution method. This essential oil showed a significant antibacterial activity against S. choleraesuis at the concentration of 200 µg/mL. Twenty-five volatile compounds were characterized from this essential oil by GC-MS, and aldehyde compounds were found abundant and accounted for more than three-fourths of the essential oil. Among the compounds characterized, dodecanal (C12 ) was the most abundant (55.5%), followed by decanal (C10 ) (11.6%). Both alkanals were effective against S. choleraesuis with the minimum growth inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 100 µg/mL. The most potent antibacterial activity against this bacterium was found with two minor compounds, dodecanol (lauryl alcohol) and 2E-dodecenal, both with each MBC of 6.25 µg/mL. Their primary antibacterial action against S. choleraesuis provably comes from their ability to function as nonionic surface-active agents (surfactants), disrupting the native function of integral membrane proteins nonspecifically. Thus, the antibacterial activity is mediated by biophysical processes. In the case of 2E-alkenals, a biochemical mechanism is also somewhat involved, depending on their alkyl chain length.
authors: Department of Environmental, Policy and Management, University of California, Berkeley, CA, 94720, USA.|Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka, 558-8585, Japan.
authors: Ken-Ichi
authors: K
authors: Fujita
authors: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
authors: Warinthorn
authors: W
authors: Chavasiri
authors: Department of Environmental, Policy and Management, University of California, Berkeley, CA, 94720, USA.
authors: Isao
authors: I
authors: Kubo
mesh_terms: D000447:Aldehydes / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D028526:Coriandrum / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009822:Oils, Volatile / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000494:pharmacology*; D012475:Salmonella / Q000187:drug effects*; D014744:Vietnam
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D009822:Oils, Volatile; D010938:Plant Oils; C021170:decanaldehyde
keywords: Polygonum odoratum; Salmonella choleraesuis; Vietnam coriander; bactericidal activity; dodecanol; surfactants