title: Bone marrow-derived, neural-like cells have the characteristics of neurons to protect the peripheral nerve in microenvironment.
abstract: Effective repair of peripheral nerve defects is difficult because of the slow growth of new axonal growth. We propose that "neural-like cells" may be useful for the protection of peripheral nerve destructions. Such cells should prolong the time for the disintegration of spinal nerves, reduce lesions, and improve recovery. But the mechanism of neural-like cells in the peripheral nerve is still unclear. In this study, bone marrow-derived neural-like cells were used as seed cells. The cells were injected into the distal end of severed rabbit peripheral nerves that were no longer integrated with the central nervous system. Electromyography (EMG), immunohistochemistry, and transmission electron microscopy (TEM) were employed to analyze the development of the cells in the peripheral nerve environment. The CMAP amplitude appeared during the 5th week following surgery, at which time morphological characteristics of myelinated nerve fiber formation were observed. Bone marrow-derived neural-like cells could protect the disintegration and destruction of the injured peripheral nerve.
authors: Regenerative Medicine Center, The Second Military Medical University, Shanghai 200433, China ; Nanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing 210046, China.
authors: Shi-Lei
authors: SL
authors: Guo
authors: Regenerative Medicine Center, The Second Military Medical University, Shanghai 200433, China.
authors: Zhi-Ying
authors: ZY
authors: Zhang
authors: Nanjing Regenerative Medicine Engineering and Technology Research Center, Nanjing 210046, China.
authors: Yan
authors: 0000-0002-7940-6307
authors: Y
authors: Xu
authors: Regenerative Medicine Center, The Second Military Medical University, Shanghai 200433, China.
authors: Yun-Xia
authors: YX
authors: Zhi
authors: Regenerative Medicine Center, The Second Military Medical University, Shanghai 200433, China.
authors: Chang-Jie
authors: CJ
authors: Han
authors: Department of Health Statistics, The Second Military Medical University, Shanghai 200433, China.
authors: Yu-Hao
authors: YH
authors: Zhou
authors: Regenerative Medicine Center, The Second Military Medical University, Shanghai 200433, China.
authors: Fang
authors: F
authors: Liu
authors: Regenerative Medicine Center, The Second Military Medical University, Shanghai 200433, China.
authors: Hai-Yan
authors: HY
authors: Lin
authors: Regenerative Medicine Center, The Second Military Medical University, Shanghai 200433, China.
authors: Chuan-Sen
authors: CS
authors: Zhang