title: Dimethylaminopyridine-supported graft polymer catalyst and its flow system.
abstract: A new heterogeneous organocatalyst, graft polymer supported dimethylaminopyridine (g-DMAP), is developed. This catalyst has a flexible structure and comprises DMAP anchored to the polyethylene-graft-polyacrylic acid (PE-g-PAA). It exhibits higher activity than DMAP supported on polystyrene cross-linked with divinylbenzene and can be recovered in batch mode acetylation. The activity and stability of this catalyst allow its application in continuous flow systems. Continuous acetylation proceeds with excellent conversion, and a turnover number of 560 can be achieved using g-DMAP. Parallel fixed bed reactors were used to scale up the synthesis of this continuous flow system. Eight parallel fixed bed reactors displayed excellent conversion.
authors: Yokohama University of Pharmacy, Department of Medicinal Chemistry, 601 Matano-cho Totsuka-ku, Yokohama 245-0066 (Japan).
authors: Yoshinori
authors: Y
authors: Okuno
authors: Yokohama University of Pharmacy, Department of Medicinal Chemistry, 601 Matano-cho Totsuka-ku, Yokohama 245-0066 (Japan).
authors: Shigeki
authors: S
authors: Isomura
authors: Yokohama University of Pharmacy, Department of Medicinal Chemistry, 601 Matano-cho Totsuka-ku, Yokohama 245-0066 (Japan).
authors: Takahiro
authors: T
authors: Kamakura
authors: Yokohama University of Pharmacy, Department of Medicinal Chemistry, 601 Matano-cho Totsuka-ku, Yokohama 245-0066 (Japan).
authors: Fumiaki
authors: F
authors: Sano
authors: Yokohama University of Pharmacy, Department of Medicinal Chemistry, 601 Matano-cho Totsuka-ku, Yokohama 245-0066 (Japan).
authors: Kaoru
authors: K
authors: Tamahori
authors: Yokohama University of Pharmacy, Department of Medicinal Chemistry, 601 Matano-cho Totsuka-ku, Yokohama 245-0066 (Japan).
authors: Takahiro
authors: T
authors: Goto
authors: Yokohama University of Pharmacy, Department of Medicinal Chemistry, 601 Matano-cho Totsuka-ku, Yokohama 245-0066 (Japan).
authors: Takahiro
authors: T
authors: Hayashida
authors: Yokohama University of Pharmacy, Department of Medicinal Chemistry, 601 Matano-cho Totsuka-ku, Yokohama 245-0066 (Japan).
authors: Yuuichi
authors: Y
authors: Kitagawa
authors: Yokohama University of Pharmacy, Department of Medicinal Chemistry, 601 Matano-cho Totsuka-ku, Yokohama 245-0066 (Japan).
authors: Ami
authors: A
authors: Fukuhara
authors: Yokohama University of Pharmacy, Department of Medicinal Chemistry, 601 Matano-cho Totsuka-ku, Yokohama 245-0066 (Japan). k.takeda@hamayaku.ac.jp.
authors: Kazuyoshi
authors: K
authors: Takeda
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000631:Aminopyridines / Q000737:chemistry*; D002384:Catalysis; D011095:Polyethylenes / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D000631:Aminopyridines; D011095:Polyethylenes; C083316:(polyethylene-acrylic acid) copolymer
keywords: acetylation; continuous flow reaction; dmap; grafted copolymer; immobilized catalyst