title: Dietary carbohydrate and prostate cancer risk: a meta-analysis.
abstract: Carbohydrate intake has been inconsistently associated with risk of prostate cancer. We review and quantitatively summarize the evidence from observational studies in a meta-analysis. We searched the PubMed database for observational studies related to the association of carbohydrate intake and prostate cancer risk up to December 25, 2013. Summary relative risks (RRs) were estimated by the use of a random effects model. We included 13 case-control studies with 4,367 cases and 6,205 controls, and 5 cohort studies with 3,679 cases and 74,115 participants in this meta-analysis. The summary RR of prostate cancer for the highest vs. the lowest carbohydrate intake was 1.06 [95% confidence interval (CI): 0.93-1.20, I(2) = 46.8%] for all included studies. In the subgroup analyses stratified by study design, the summary RRs for the highest vs. the lowest carbohydrate intake were 1.04 (95% CI: 0.87-1.23) for case-control studies and 1.06 (95% CI: 0.88-1.28) for cohort studies. For the 5 studies that reported results for advanced prostate cancer, the summary RR was 0.92 (95% CI: 0.71-1.20). This meta-analysis of observational studies indicates that there is no association between carbohydrate intake and prostate cancer risk. Further studies are needed to confirm our findings.
authors: a Department of Epidemiology and Health Statistics , Qingdao University Medical College , Qingdao , China.
authors: Long
authors: L
authors: Zhai
authors: Shuo
authors: S
authors: Cheng
authors: Dongfeng
authors: D
authors: Zhang
mesh_terms: D004040:Dietary Carbohydrates / Q000009:adverse effects*; D006801:Humans; D008297:Male; D064887:Observational Studies as Topic; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D004040:Dietary Carbohydrates