title: Coxsackievirus B3 replication and pathogenesis.
abstract: Viruses such as coxsackievirus B3 (CVB3) are entirely host cell-dependent parasites. Indeed, they must cleverly exploit various compartments of host cells to complete their life cycle, and consequently launch disease. Evolution has equipped this pico-rna-virus, CVB3, to use different strategies, including CVB3-induced direct damage to host cells followed by a host inflammatory response to CVB3 infection, and cell death to super-additively promote target organ tissue injury, and dysfunction. In this update, the patho-stratagems of CVB3 are explored from molecular, and systems-level approaches. In summarizing recent developments in this field, we focus particularly on mechanisms by which CVB3 can harness different host cell processes including kinases, host cell-killing and cell-eating machineries, matrix metalloproteinases and miRNAs to promote disease.
authors: UBC James Hogg Research Centre, Institute for Heart & Lung Health, St. Paul's Hospital, University of British Columbia, Vancouver, BC, V6Z, Canada.
authors: Farshid S
authors: FS
authors: Garmaroudi
authors: David
authors: D
authors: Marchant
authors: Reid
authors: R
authors: Hendry
authors: Honglin
authors: H
authors: Luo
authors: Decheng
authors: D
authors: Yang
authors: Xin
authors: X
authors: Ye
authors: Junyan
authors: J
authors: Shi
authors: Bruce M
authors: BM
authors: McManus
mesh_terms: D029822:Enterovirus B, Human / Q000472:pathogenicity / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D014774:Virulence; D014779:Virus Replication
keywords: autophagy; coxsackievirus B3; matrix metalloproteinases; miRNA; signal-transduction networks; systems virology; viral myocarditis