title: Increased human epididymis protein 4 in benign gynecological diseases complicated with chronic renal insufficiency patients.
abstract: We examined the serum concentration of human epididymis protein (HE4) in patients with benign gynecological diseases complicated with chronic renal deficiency and its significance in the differential diagnosis of benign and malignant gynecological diseases. Serum HE4 and cancer antigen 125 concentrations were detected by chemiluminescence. Clinically or pathologically confirmed gynecological diseases were grouped and retrospectively analyzed, including 50 cases of gynecological benign diseases, 35 cases of non-mucinous epithelial ovarian carcinoma, 36 cases of endometrial adenocarcinoma, 15 cases of gynecological benign diseases patients complicated with chronic renal deficiency, 15 cases of gynecological diseases without chronic renal deficiency, and 30 normal controls. Serum HE4 values in the ovarian cancer group, endometrial cancer group, gynecological benign diseases with chronic renal deficiency group, and chronic renal deficiency group were significantly increased compared with the benign gynecological diseases and normal control groups, showing a significant difference (P < 0.001). A comparison of 4 groups with high HE4 showed that the HE4 level in the 2 groups with renal deficiency were higher than those in the ovarian cancer and endometrial cancer groups, but the difference was not significant (P > 0.05); there was no significant difference between 2 groups with renal deficiency (P > 0.05). Serum concentration of HE4 was high in patients with chronic renal deficiency, which should be distinguished during differential diagnosis of gynecological benign and malignant tumors in patients with chronic renal deficiency to avoid misdiagnosis.
authors: Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China yanwenlvcn@126.com.
authors: Y W
authors: YW
authors: Lv
authors: Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.
authors: L
authors: L
authors: Yang
authors: Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.
authors: M
authors: M
authors: Zhang
authors: Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.
authors: L H
authors: LH
authors: Jiang
authors: Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.
authors: J H
authors: JH
authors: Niu
authors: Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.
authors: J
authors: J
authors: Hou
authors: Department of Obstetrics and Gynecology, PLA 463rd Hospital, Shenyang, Liaoning Province, China.
authors: X H
authors: XH
authors: Cui
mesh_terms: D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D005831:Genital Diseases, Female / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications; D011506:Proteins / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications; D012189:Retrospective Studies; D000081102:WAP Four-Disulfide Core Domain Protein 2
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; D011506:Proteins; D000081102:WAP Four-Disulfide Core Domain Protein 2; C569698:WFDC2 protein, human