title: Anti-thyroid antibodies and cerebrospinal fluid findings in neuromyelitis optica spectrum disorders.
abstract: OBJECTIVE
  To determine the differences of thyroid diseases and ATAbs in multiple sclerosis (MS) and NMOSDs, and to assess the independent impact factors of longitudinally extensive transverse myelitis (LETM) in NMOSDs.
  
  
  RESULTS
  Anti-thyroid peroxidase antibodies-positive (TPOAb(+)) and anti-thyroglobulin antibodies-positive (TGAb(+)) were most frequent in NMOSDs. LETM and lesions ≥6 vertebral segments were more frequent in TPOAb(+) NMOSDs than in TPOAb-negative (TPOAb(-)) NMOSDs. TGAb(+) NMOSDs with LETM were significantly more frequent than TGAb-negative (TGAb(-)) NMOSDs. TPOAb(+) and cerebrospinal fluid (CSF) abnormalities were independently associated with LETM.
  
  
  CONCLUSIONS
  Our findings demonstrate that ATAbs and thyroid diseases are significantly different in MS and NMOSD patients and CSs. TPOAb(+) and CSF abnormalities may be possible predictors of the severity of spinal cord lesions.
authors: Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: Haiyan
authors: H
authors: Li
authors: Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: Yongqiang
authors: Y
authors: Dai
authors: Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: Ai-Min
authors: AM
authors: Wu
authors: Laboratory of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: Xiaobo
authors: X
authors: Sun
authors: Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
authors: Yinyao
authors: Y
authors: Lin
authors: Department of Neurology, Dong Guang People's Hospital, Dongguang, Guangdong, China.
authors: Kefeng
authors: K
authors: Lv
authors: Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address: lzq1828@163.com.
authors: Zhengqi
authors: Z
authors: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000175:diagnosis; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000134:cerebrospinal fluid*; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D013963:Thyroid Hormones
keywords: Anti-peroxidase antibodies; Anti-thyroglobulin antibodies; Cerebrospinal fluid; Magnetic resonance imaging; Multiple sclerosis; Neuromyelitis optica spectrum disorders