title: Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer.
abstract: OBJECTIVE
  Non-small cell lung cancer (NSCLC) is among the leading causes of cancer-related deaths worldwide. In certain human cancer types, Src is associated with cancer progression and refractory cancer. To improve the prognoses of NSCLC patients, we evaluated Src kinase-associated phosphoprotein 2 (SKAP2), a factor associated with integrin-stimulated cytoskeletal rearrangement, as a new therapeutic target.
  
  
  METHODS
  We performed immunohistochemistry for SKAP2 in 99 NSCLC samples and evaluated the relationship between SKAP2 expression, clinicopathological factors and prognosis.
  
  
  RESULTS
  Higher SKAP2 expression was detected in cancerous tissues and was predominantly expressed in the cytoplasm. Elevated SKAP2 expression levels were associated with poor prognosis (p=0.007) and shorter survival time after recurrence (p=0.035). High SKAP2 expression was an independent prognostic factor in NSCLC patients (p=0.027).
  
  
  CONCLUSIONS
  High SKAP2 expression levels in NSCLC tissues could be a powerful biomarker of poor prognosis. Therefore, SKAP2 is a promising candidate molecular target for NSCLC treatment.
authors: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors: Satoshi
authors: S
authors: Kuranami
authors: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan bori45@gunmau.ac.jp.
authors: Takehiko
authors: T
authors: Yokobori
authors: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors: Akira
authors: A
authors: Mogi
authors: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors: Bolag
authors: B
authors: Altan
authors: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors: Toshiki
authors: T
authors: Yajima
authors: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors: Ryoichi
authors: R
authors: Onozato
authors: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors: Yoko
authors: Y
authors: Azuma
authors: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors: Misaki
authors: M
authors: Iijima
authors: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors: Takayuki
authors: T
authors: Kosaka
authors: Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors: Hiroyuki
authors: H
authors: Kuwano
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D047908:Intracellular Signaling Peptides and Proteins; C116431:src kinase associated phosphoprotein 2
keywords: SKAP2; Src; actin assembly; lung cancer