title: PAT: From Western solid dosage forms to Chinese materia medica preparations using NIR-CI.
abstract: Near-infrared chemical imaging (NIR-CI) is an emerging technology that combines traditional near-infrared spectroscopy with chemical imaging. Therefore, NIR-CI can extract spectral information from pharmaceutical products and simultaneously visualize the spatial distribution of chemical components. The rapid and non-destructive features of NIR-CI make it an attractive process analytical technology (PAT) for identifying and monitoring critical control parameters during the pharmaceutical manufacturing process. This review mainly focuses on the pharmaceutical applications of NIR-CI in each unit operation during the manufacturing processes, from the Western solid dosage forms to the Chinese materia medica preparations. Finally, future applications of chemical imaging in the pharmaceutical industry are discussed.
authors: Beijing University of Chinese Medicine, China, 100102.|Pharmaceutical Engineering and New Drug Development of Traditional Chinese Medicine (TCM) of Ministry of Education, China, 100102.|Key Laboratory of TCM-information Engineering of State Administration of TCM, Beijing, China, 100102.|Beijing Key Laboratory for Basic and Development Research on Chinese Medicine, Beijing, China, 100102.
authors: Luwei
authors: L
authors: Zhou
authors: Beijing University of Chinese Medicine, China, 100102.|Pharmaceutical Engineering and New Drug Development of Traditional Chinese Medicine (TCM) of Ministry of Education, China, 100102.|Key Laboratory of TCM-information Engineering of State Administration of TCM, Beijing, China, 100102.|Beijing Key Laboratory for Basic and Development Research on Chinese Medicine, Beijing, China, 100102.
authors: Manfei
authors: M
authors: Xu
authors: Beijing University of Chinese Medicine, China, 100102.|Pharmaceutical Engineering and New Drug Development of Traditional Chinese Medicine (TCM) of Ministry of Education, China, 100102.|Key Laboratory of TCM-information Engineering of State Administration of TCM, Beijing, China, 100102.|Beijing Key Laboratory for Basic and Development Research on Chinese Medicine, Beijing, China, 100102.
authors: Zhisheng
authors: Z
authors: Wu
authors: Beijing University of Chinese Medicine, China, 100102.|Pharmaceutical Engineering and New Drug Development of Traditional Chinese Medicine (TCM) of Ministry of Education, China, 100102.|Key Laboratory of TCM-information Engineering of State Administration of TCM, Beijing, China, 100102.|Beijing Key Laboratory for Basic and Development Research on Chinese Medicine, Beijing, China, 100102.
authors: Xinyuan
authors: X
authors: Shi
authors: Beijing University of Chinese Medicine, China, 100102.|Pharmaceutical Engineering and New Drug Development of Traditional Chinese Medicine (TCM) of Ministry of Education, China, 100102.|Key Laboratory of TCM-information Engineering of State Administration of TCM, Beijing, China, 100102.|Beijing Key Laboratory for Basic and Development Research on Chinese Medicine, Beijing, China, 100102.
authors: Yanjiang
authors: Y
authors: Qiao
mesh_terms: D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008419:Materia Medica / Q000737:chemistry*; D011786:Quality Control; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013607:Tablets / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D013607:Tablets
keywords: Chinese materia medica preparation; Western solid dosage form; near-infrared chemical imaging; pharmaceutical application