title: Novel carboxaldehyde mediated synthetic pathway for 5'-amino adenosine analogues.
abstract: Modifications of the 5'-position of adenosine have been prepared via a novel 5'-carboxaldehyde synthon. The described methodology should prove useful for making related compounds in which amine-derived moieties off the 5'-position of adenosine (or related nucleoside congeners) can be easily incorporated via reductive amination, especially for the incorporation of aromatic amines.
authors: a Department of Pathology, University of Michigan Medical School , Ann Arbor , MI , USA.
authors: Garrett S
authors: GS
authors: Gibbons
authors: Hollis D
authors: HD
authors: Showalter
authors: Zaneta
authors: Z
authors: Nikolovska-Coleska
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000586:Amination; D060326:Chemistry Techniques, Synthetic / Q000379:methods*
chemical_list: D000241:Adenosine
keywords: Synthetic methodology; enzyme inhibition; modified nucleosides; reductive amination