title: Predictors of successful closure of patent ductus arteriosus with indomethacin.
abstract: OBJECTIVE
  To determine whether platelet counts can predict the likelihood of successful closure of patent ductus arteriosus (PDA) with indomethacin.
  
  
  METHODS
  This was a retrospective cohort study of infants <32 weeks' gestational age (GA) and birth weight <1500 g with PDA. Clinical characteristics between infants who achieved ductal closure with indomethacin and those who failed were compared. Multivariable logistic regression was used to identify predictors of successful ductal closure.
  
  
  RESULTS
  In infants with hemodynamically significant PDA, older GA (odds ratio=1.54; 95% confidence interval: 1.12 to 2.13), male gender (odds ratio=3.02; 95% confidence interval: 1.08 to 8.49) and higher platelet count (odds ratio=1.5; 95% confidence interval: 1.04 to 2.17) prior to indomethacin treatment were associated with successful ductal closure with indomethacin.
  
  
  CONCLUSIONS
  Older GA, male gender and higher platelet count at time of treatment of hemodynamically significant PDA are predictors of successful ductal closure with indomethacin.
authors: Division of Neonatal-Perinatal Medicine, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: M F
authors: MF
authors: Ahamed
authors: Division of Neonatology, Alpert Medical School of Brown University, Providence, RI, USA.
authors: P
authors: P
authors: Verma
authors: Division of Pediatric Cardiology, Mount Sinai Hospital, Icahn School of Medicine, New York, NY, USA.
authors: S
authors: S
authors: Lee
authors: Division of Neonatal-Perinatal Medicine, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: M
authors: M
authors: Vega
authors: Department of Epidemiology & Population Health, Division of Biostatistics, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: D
authors: D
authors: Wang
authors: Department of Epidemiology & Population Health, Division of Biostatistics, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: M
authors: M
authors: Kim
authors: Division of Neonatal-Perinatal Medicine, The Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.
authors: M
authors: M
authors: Fuloria
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D015331:Cohort Studies; D004374:Ductus Arteriosus, Patent / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005865:Gestational Age; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D007230:Infant, Low Birth Weight / Q000502:physiology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology; D016015:Logistic Models; D008297:Male; D010976:Platelet Count / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012737:Sex Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin