title: An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents.
abstract: We describe the synthesis of C8-alkynyl adenine pyranonucleosides 4, 5, and 8-phenylethynyl-adenine (II), via Sonogashira cross-coupling reaction under microwave irradiation. Compounds 4e and II were less cytostatic than 5-fluorouracil (almost an order of magnitude) against murine leukemia (L1210) and human cervix carcinoma (HeLa) cells, while the same compounds proved to be more active than 5-fluorouracil against human lymphocyte (CEM) cells.
authors: Laboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
authors: Athina
authors: A
authors: Dimopoulou
authors: Laboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
authors: Stella
authors: S
authors: Manta
authors: Laboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
authors: Vanessa
authors: V
authors: Parmenopoulou
authors: Laboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
authors: Nikolaos
authors: N
authors: Kollatos
authors: Laboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
authors: Ourania
authors: O
authors: Christidou
authors: Laboratory of Organic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki Thessaloniki, Greece.
authors: Virginia V
authors: VV
authors: Triantakonstanti
authors: Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven Leuven, Belgium.
authors: Dominique
authors: D
authors: Schols
authors: Laboratory of Bioorganic Chemistry, Department of Biochemistry and Biotechnology, University of Thessaly Larissa, Greece.
authors: Dimitri
authors: D
authors: Komiotis
keywords: 8-bromoadenine; N6-benzoyladenine pyranonucleosides; Sonogashira coupling reaction; cytotoxic activity; microwave irradiation