title: [Impact of response of primary tumor and positive axillary lymph node to neoadjuvant chemotherapy on breast cancer survival].
abstract: OBJECTIVE
  To explore the relationship between response of primary tumor and positive axillary lymph node to neoadjuvant chemotherapy and examine its correlation with breast cancer distant disease-free survival (DDFS).
  
  
  METHODS
  The clinical data of 678 needle biopsy proved node positive breast cancer patients on neoadjuvant chemotherapy were analyzed retrospectively.
  
  
  RESULTS
  The median follow-up period was 45 (6-143) months. The 4-year DDFS in group A (ypT0/is ypN0),B (ypT0/is ypN+), C (ypT ≥ 1mi ypN0) and D (ypT ≥ 1mi ypN+) were 96.4%, 85.7%, 86.7% and 80.2% respectively. As compared with group A, the relative risk ratios of groups B, C and D were 2.32, 2.09 and 4.07 (P = 0.006).Significant difference existed in DDFS between groups A and B (96.4% vs 85.7%, P = 0.045) and groups A and C (96.4% vs 86.7%, P = 0.040).
  
  
  CONCLUSIONS
  Pathological response of both primary tumor and positive axillary node are prognostic and crucial for evaluating the efficacy of neoadjuvant chemotherapy.
authors: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors: Xing
authors: X
authors: Wang
authors: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors: Yingjian
authors: Y
authors: He
authors: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors: Jinfeng
authors: J
authors: Li
authors: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors: Yuntao
authors: Y
authors: Xie
authors: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors: Tianfeng
authors: T
authors: Wang
authors: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors: Zhaoqing
authors: Z
authors: Fan
authors: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China.
authors: Tie
authors: T
authors: Fan
authors: Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China. Email: ouyanghongtao@263.net.
authors: Tao
authors: T
authors: Ouyang
mesh_terms: D001365:Axilla; D001943:Breast Neoplasms; D018572:Disease-Free Survival; D006801:Humans; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D020360:Neoadjuvant Therapy; D011379:Prognosis; D012189:Retrospective Studies