title: Protective effect of vitamin E against diabetes-induced oxidized LDL and aorta cell wall proliferation in rat.
abstract: Hyperlipidemia and oxidized-low-density lipoproteins (Ox-LDL) are important independent cardiovascular risk factors that have been shown to stimulate vascular smooth muscle cell (VSMC) proliferation. The purpose of the present study was to investigate the effect of vitamin E on Ox-LDL, lipid profile, C-reactive protein (CRP), and VSMC proliferation of rat aorta.
  
  
  
  Male Wistar rats (n = 32) were divided into four groups namely: sham (SH), control (C), non-treated diabetic, and vitamin E-treated diabetic (VETD) groups. Ox-LDL, lipid profile, CRP and VSMC proliferation of aorta were measured after 42 days.
  
  
  
  The results revealed that along with a significant increase in VSMC proliferation, the amount of CRP, Ox-LDL, and lipid profiles in diabetic rats. VSMC proliferation was significantly ameliorated, and elevated CRP, Ox-LDL, and lipid profiles were also restored to those of shams in VETD.
  
  
  
  These findings strongly support the idea that diabetes induces Ox-LDL-mediated oxidative stress and VSMC proliferation in aorta of rat and imply that vitamin E has a strong protective effect as an antioxidant.
authors: Dept. of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
authors: Alireza
authors: A
authors: Shirpoor
authors: Dept. of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
authors: Leila
authors: L
authors: Norouzi
authors: Dept. of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
authors: Samira
authors: S
authors: Nemati
authors: Dept. of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
authors: Mohammad Hasan
authors: MH
authors: Khadem Ansari
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001011:Aorta / Q000473:pathology*; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000517:prevention & control; D049109:Cell Proliferation; D003920:Diabetes Mellitus / Q000473:pathology*; D006949:Hyperlipidemias / Q000097:blood*; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood* / Q000378:metabolism; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000502:physiology*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D008055:Lipids; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D014810:Vitamin E; D002097:C-Reactive Protein
keywords: Ox-LDL; Vitamin E; Diabetes; VSMC proliferation