title: Acylsulfonamide-Functionalized Zwitterionic Gold Nanoparticles for Enhanced Cellular Uptake at Tumor pH.
abstract: A nanoparticle design featuring pH-responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH 7.4, becoming positively charged at tumor pH (<6.5). The particle uptake and cytotoxicity increase over this pH range. This pH-controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy.
authors: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003 (USA).|Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501 (Japan).
authors: Tsukasa
authors: T
authors: Mizuhara
authors: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003 (USA).
authors: Krishnendu
authors: K
authors: Saha
authors: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003 (USA).
authors: Daniel F
authors: DF
authors: Moyano
authors: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003 (USA).
authors: Chang Soo
authors: CS
authors: Kim
authors: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003 (USA).
authors: Bo
authors: B
authors: Yan
authors: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003 (USA).
authors: Young-Kwan
authors: YK
authors: Kim
authors: Department of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, MA 01003 (USA). rotello@chem.umass.edu.
authors: Vincent M
authors: VM
authors: Rotello
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D007477:Ions; D008024:Ligands; D013449:Sulfonamides; D006046:Gold
keywords: antitumor agents; cellular uptake; gold; nanoparticles; zwitterionic ligands