title: Plasma lipoprotein(a) levels and atherosclerotic renal artery stenosis in hypertensive patients.
abstract: OBJECTIVE
  The contribution of emergent cardiovascular risk factors to atherosclerotic renal artery stenosis (ARAS) is debated. We investigated the relationship of lipoprotein(a) and prothrombotic factors with ARAS in hypertension.
  
  
  METHODS
  In 50 hypertensive patients with angiographic evidence of ARAS and 58 hypertensive patients who had comparable cardiovascular risk factor burden but no evidence of renovascular disease, we measured renal function, lipoprotein(a), homocysteine, and hemostatic-fibrinolytic markers.
  
  
  RESULTS
  Patients with ARAS were more frequently smokers and had longer duration of hypertension, heavier antihypertensive treatment, and worse renal function than controls. Lipoprotein(a) was higher in patients with ARAS than controls, whereas no differences were found in homocysteine and all hemostatic variables. Multivariate analysis showed that lipoprotein(a) was associated with ARAS independent of other confounders including renal function and history of coronary heart, cerebrovascular, and peripheral artery disease.
  
  
  CONCLUSIONS
  Lipoprotein(a) might contribute to the development of ARAS and detection of elevated levels of this lipoprotein could raise the suspicion of renovascular disease in patients with high blood pressure.
authors: Hypertension Unit, Internal Medicine, Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy.
authors: Cristiana
authors: C
authors: Catena
authors: GianLuca
authors: G
authors: Colussi
authors: Francesca
authors: F
authors: Nait
authors: Frine
authors: F
authors: Capobianco
authors: Leonardo A
authors: LA
authors: Sechi
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology*; D007677:Kidney Function Tests; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000209:etiology / Q000473:pathology*; D012307:Risk Factors
chemical_list: D017270:Lipoprotein(a)