title: [Association between patatin-like phospholipase domain-containing protein 3 gene rs738409 polymorphism and non-alcoholic fatty liver disease susceptibility: a meta-analysis].
abstract: OBJECTIVE
  To explore the association between patatin-like phospholipase domain-containing protein 3(PNPLA3) gene rs738409 polymorphism and the susceptibility of non-alcoholic fatty liver disease(NAFLD).
  
  
  METHODS
  Data bases were comprehensively searched to retrace all the related studies on the association between PNPLA3 gene rs738409 polymorphism and susceptibility. Of NAFLD, the pooled OR with 95% CI of the association between PNPLA3 gene rs738409 polymorphism and NAFLD susceptibility were performed using different genetic models. Subgroup analysis based on the source of population and sensitivity analysis was performed to detect the stability of results.
  
  
  RESULTS
  28 original studies with 6 216 patients and 8 218 controls were involved in the final combination of data. Findings from the meta-analyses showed that there were strong associations between PNPLA3 gene rs738409 polymorphism and the susceptibility of NAFLD, under different genetic model comparisons[GG vs. CC:OR = 2.42, 95%CI:1.83-3.21, P < 0.001;CG vs. CC:OR = 1.28, 95%CI:1.15-1.43, P < 0.001;CG+GG vs. CC:OR = 1.31, 95%CI:1.17-1.46, P < 0.001; GG vs. CC+GC:OR = 2.26, 95%CI:1.76-2.90, P < 0.001]. Similar results were found in both Asian and Caucasian populations.
  
  
  CONCLUSIONS
  Results from the Meta-analysis strongly suggested that there appeared significant association between PNPLA3 gene rs738409 polymorphism and the susceptibility of NAFLD.
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors: Pengbo
authors: P
authors: Wu
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors: Yongxiang
authors: Y
authors: Shu
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors: Fang
authors: F
authors: Guo
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors: Hesheng
authors: H
authors: Luo
authors: Department of Gastroenterology, the People's Hospital of Guangxi Zhuang Autonomous Region.
authors: Guo
authors: G
authors: Zhang
authors: Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China. Email: tanshiyun@medmail.com.cn.
authors: Shiyun
authors: S
authors: Tan
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D004198:Disease Susceptibility; D005234:Fatty Liver; D020022:Genetic Predisposition to Disease; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D065626:Non-alcoholic Fatty Liver Disease / Q000235:genetics*; D010740:Phospholipases; D011110:Polymorphism, Genetic; D044465:White People; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent
chemical_list: D008049:Lipase; D008565:Membrane Proteins; D010740:Phospholipases; C533682:PNPLA3 protein, human; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent