title: Isoquinoline alkaloids as prolyl oligopeptidase inhibitors.
abstract: Prolyl oligopeptidase is a cytosolic serine peptidase that hydrolyses proline-containing peptides at the carboxy terminus of proline residues. It has been associated with schizophrenia, bipolar affective disorder, and related neuropsychiatric disorders and therefore may have important clinical implications. Thirty-one isoquinoline alkaloids of various structural types, previously isolated in our laboratory, were screened for their ability to inhibit prolyl oligopeptidase. Promising results have been showed by alkaloids californidine (IC50=55.6±3.5 μM), dihydrosanquinarine (IC50=99.1±7.6 μM), corypalmine (IC50=128.0±10.5 μM) and N-methyllaurotetanine (IC50=135.0±11.7 μM).
authors: ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. Electronic address: cahlikova@faf.cuni.cz.
authors: Lucie
authors: L
authors: Cahlíková
authors: ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
authors: Lucie
authors: L
authors: Hulová
authors: Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 05 Hradec Králové, Czech Republic.
authors: Martina
authors: M
authors: Hrabinová
authors: ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
authors: Jakub
authors: J
authors: Chlebek
authors: ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
authors: Anna
authors: A
authors: Hošťálková
authors: ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
authors: Markéta
authors: M
authors: Adamcová
authors: ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
authors: Marcela
authors: M
authors: Šafratová
authors: Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 05 Hradec Králové, Czech Republic.
authors: Daniel
authors: D
authors: Jun
authors: ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
authors: Lubomír
authors: L
authors: Opletal
authors: ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
authors: Miroslav
authors: M
authors: Ločárek
authors: ADINACO Research Group, Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.
authors: Kateřina
authors: K
authors: Macáková
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D001060:Aporphines / Q000737:chemistry; D004149:Dioxoles / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry; D007546:Isoquinolines / Q000737:chemistry*; D015394:Molecular Structure; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000737:chemistry*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D001060:Aporphines; D004149:Dioxoles; D006576:Heterocyclic Compounds, 4 or More Rings; D007546:Isoquinolines; D015842:Serine Proteinase Inhibitors; C510123:californidine; C000600631:N-methyllaurotetanine; C471057:corypalmine; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases
keywords: Argemonine (CID: 442168); Berberine (PubChem CID: 2353); Californidine; Californidine (PubChem CID: 45266443); Canadine (PubChem CID: 443422); Corynoline (PubChem CID: 177014); Corypalmine (PubChem CID: 185605); Dihydrosanquinarine; Dihydrosanquinarine (PubChem CID: 124069); Isoquinoline alkaloids; N-Methyllaurotetanine (PubChem CID: 16573); Prolyl oligopeptidase