title: Granulocytic myeloid derived suppressor cells expansion during active pulmonary tuberculosis is associated with high nitric oxide plasma level.
abstract: Tuberculosis (TB) is still the principal cause of death caused by a single infectious agent, and the balance between the bacillus and host defense mechanisms reflects the different manifestations of the pathology. The aim of this work was to study the role of myeloid-derived suppressor cells (MDSCs) during active pulmonary tuberculosis at the site of infection. We observed an expansion of MDSCs in the lung and blood of patients with active TB, which are correlated with an enhanced amount of nitric oxide in the plasma. We also found that these cells have the remarkable ability to suppress T-cell response, suggesting an important role in the modulation of the immune response against TB. Interestingly, a trend in the diminution of MDSCs was found after an efficacious anti-TB therapy, suggesting that these cells may be used as a potential biomarker for monitoring anti-TB therapy efficacy.
authors: Laboratory of Cellular Immunology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy; Unité de Biologie des Populations Lymphocytaires, Department of Immunology, Institut Pasteur, Paris, France; Department of Biology, University of Rome Tor Vergata, Rome, Italy.
authors: Sary
authors: S
authors: El Daker
authors: Laboratory of Cellular Immunology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy.
authors: Alessandra
authors: A
authors: Sacchi
authors: Clinical Biochemistry and Pharmacology Laboratory, "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy.
authors: Massimo
authors: M
authors: Tempestilli
authors: Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
authors: Claudia
authors: C
authors: Carducci
authors: Translational Research Unit, "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy.
authors: Delia
authors: D
authors: Goletti
authors: Translational Research Unit, "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy.
authors: Valentina
authors: V
authors: Vanini
authors: Department of Biology, University of Rome Tor Vergata, Rome, Italy.
authors: Vittorio
authors: V
authors: Colizzi
authors: Respiratory Infectious Diseases Unit, "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy.
authors: Francesco Nicola
authors: FN
authors: Lauria
authors: Laboratory of Cellular Immunology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy.
authors: Federico
authors: F
authors: Martini
authors: Laboratory of Cellular Immunology, "Lazzaro Spallanzani" National Institute for Infectious Diseases, Rome, Italy.
authors: Angelo
authors: A
authors: Martino
mesh_terms: D001120:Arginine / Q000097:blood; D049109:Cell Proliferation; D006098:Granulocytes / Q000473:pathology*; D006801:Humans; D022423:Myeloid Cells / Q000473:pathology*; D009569:Nitric Oxide / Q000097:blood*; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000473:pathology*
chemical_list: D009569:Nitric Oxide; D001120:Arginine