title: Obesity and cancer progression: is there a role of fatty acid metabolism?
abstract: Currently, there is renewed interest in elucidating the metabolic characteristics of cancer and how these characteristics may be exploited as therapeutic targets. Much attention has centered on glucose, glutamine and de novo lipogenesis, yet the metabolism of fatty acids that arise from extracellular, as well as intracellular, stores as triacylglycerol has received much less attention. This review focuses on the key pathways of fatty acid metabolism, including uptake, esterification, lipolysis, and mitochondrial oxidation, and how the regulators of these pathways are altered in cancer. Additionally, we discuss the potential link that fatty acid metabolism may serve between obesity and changes in cancer progression.
authors: Discipline of Physiology, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia ; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
authors: Seher
authors: S
authors: Balaban
authors: Discipline of Physiology, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia ; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia.
authors: Lisa S
authors: LS
authors: Lee
authors: Discipline of Physiology, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia.
authors: Mark
authors: M
authors: Schreuder
authors: Discipline of Physiology, School of Medical Sciences and Bosch Institute, The University of Sydney, Sydney, NSW 2006, Australia ; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia ; Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, The University of Sydney, Sydney, NSW 2006, Australia.
authors: Andrew J
authors: AJ
authors: Hoy
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D009765:Obesity / Q000378:metabolism* / Q000473:pathology
chemical_list: D005227:Fatty Acids