title: Neuroanatomy of Alzheimer's Disease and Late-Life Depression: A Coordinate-Based Meta-Analysis of MRI Studies.
abstract: Depression and cognitive impairment are both common disorders in elderly people and frequently occur together. Due to the presence of a common set of behavioral and cognitive symptoms, differential diagnosis may become arduous. Neuroimaging may offer a good tool during diagnosis. We performed a coordinate-based meta-analysis to compare gray matter changes in Alzheimer's disease (AD) and late-life depression (LLD). AD and LLD led to brain atrophy in networks only partially overlapping. Both conditions are linked to a reduction of the bilateral hippocampal volume, but AD is correlated with great atrophy in the left anterior hippocampus and bilateral posterior cingulate cortex, while LLD is correlated with great atrophy in the precuneus, superior frontal gyrus, and ventromedial frontal cortex. Present results shed some light on neural underpinnings of AD and LLD and provide new useful evidence for differential diagnosis.
authors: Department of Psychology, "Sapienza" University of Rome, Italy.|Neuropsychology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy.
authors: Maddalena
authors: M
authors: Boccia
authors: Department of Life, Health and Environmental Sciences, L'Aquila University, L'Aquila, Italy.
authors: Mauro
authors: M
authors: Acierno
authors: Neuropsychology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy.|Department of Life, Health and Environmental Sciences, L'Aquila University, L'Aquila, Italy.
authors: Laura
authors: L
authors: Piccardi
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D003863:Depression / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016013:Likelihood Functions; D008279:Magnetic Resonance Imaging; D008297:Male
keywords: Aging; Alzheimer’s disease; dementia; late-life depression; magnetic resonance imaging; neuroimaging; voxel-based morphometry