title: Circulating monoclonal light chains and acute kidney injury: the role of the renal biopsy with emphasis on ultrastructural evaluation in assessing and understanding renal injury.
abstract: Tubular interstitial injury as a consequence of circulating monotypical light chains in patients with an underlying plasma cell dyscrasia may be difficult to identify. Renal involvement is a common early manifestation in these patients, and accurate/careful pathologic evaluation can uncover an underlying plasma cell dyscrasia. While immunofluorescence evaluation can detect monotypical deposition of light chains in the tubular interstitial compartment and may suggest a possible underlying plasma cell dyscrasia, electron microscopic examination is crucial in documenting such involvement. Ultrastructural immunolabeling can help in solidifying the pathological assessment.
authors: Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center , Shreveport, LA , USA.
authors: Jeffrey
authors: J
authors: Aufman
authors: Guillermo A
authors: GA
authors: Herrera
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000473:pathology*; D000818:Animals; D001706:Biopsy; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000648:ultrastructure*; D007668:Kidney / Q000473:pathology*; D007684:Kidney Tubules / Q000648:ultrastructure*; D010265:Paraproteinemias / Q000175:diagnosis / Q000473:pathology*
chemical_list: D007147:Immunoglobulin Light Chains
keywords: Light chains; tubulopathy; ultrastructure