title: Simplified Citrate Anticoagulation for CRRT Without Calcium Replacement.
abstract: Since 2012, citrate anticoagulation is the recommended anticoagulation strategy for continuous renal replacement therapy (CRRT). The main drawback using citrate as anticoagulant compared with heparin is the need for calcium replacement and the rigorous control of calcium levels. This study investigated the possibility to achieve anticoagulation while eliminating the need for calcium replacement. This was successfully achieved by including citrate and calcium in all CRRT solutions. Thereby the total calcium concentration was kept constant throughout the extracorporeal circuit, whereas the ionized calcium was kept at low levels enough to avoid clotting. Being a completely new concept, only five patients with acute renal failure were included in a short, prospective, intensely supervised nonrandomized pilot study. Systemic electrolyte levels and acid-base parameters were stable and remained within physiologic levels. Ionized calcium levels declined slightly initially but stabilized at 1.1 mmol/L. Plasma citrate concentrations stabilized at approximately 0.6 mmol/L. All postfilter ionized calcium levels were <0.5 mmol/L, that is, an anticoagulation effect was reached. All filter pressures were normal indicating no clotting problems, and no visible clotting was observed. No calcium replacement was needed. This pilot study suggests that it is possible to perform regional citrate anticoagulation without the need for separate calcium infusion during CRRT.
authors: From the *Department of Clinical Sciences, Anaesthesiology and Intensive Care, Lund University, Lund, Sweden; †Gambro Lundia AB, Lund, Sweden; ‡Department of Nephrology, Lund University, Lund, Sweden; and §Department of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden.
authors: Marcus
authors: M
authors: Broman
authors: Bengt
authors: B
authors: Klarin
authors: Karin
authors: K
authors: Sandin
authors: Ola
authors: O
authors: Carlsson
authors: Anders
authors: A
authors: Wieslander
authors: Jan
authors: J
authors: Sternby
authors: Gabriela
authors: G
authors: Godaly
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D019343:Citric Acid / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D015312:Hemodialysis Solutions / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D017582:Renal Replacement Therapy / Q000379:methods*
chemical_list: D000925:Anticoagulants; D015312:Hemodialysis Solutions; D019343:Citric Acid; D002118:Calcium