title: Mannose-specific lectins that inhibit HIV infection bind nonspecifically to HIV Env-expressing cells.
abstract: An approach to curing HIV/AIDS is to specifically kill all infected cells. Because the lectins, Hippeastrum hybrid agglutinin (HHA) and Galanthus nivalis agglutinin (GNA), are potent inhibitors of HIV infection and bind the oligomannans on the HIV Env protein, we hypothesized that they would bind specifically to cells expressing the HIV Env protein on their plasma membrane. Flow cytometry experiments indicated, however, that these lectins bind equivalently to both Env-expressing and control cells without Env.
authors: Deborah
authors: D
authors: Chau
authors: Michael
authors: M
authors: Yee
authors: Senait
authors: S
authors: Gebremedhin
authors: Jennifer
authors: J
authors: Cheung
authors: Takahiro
authors: T
authors: Chino
authors: Nejat
authors: N
authors: Düzgüneş
mesh_terms: D019380:Anti-HIV Agents / Q000378:metabolism / Q000627:therapeutic use; D002462:Cell Membrane / Q000378:metabolism; D002999:Clone Cells; D003470:Culture Media; D005434:Flow Cytometry; D016650:Fluorescein-5-isothiocyanate; D005456:Fluorescent Dyes; D015699:HIV Envelope Protein gp120 / Q000378:metabolism*; D015700:HIV Envelope Protein gp41 / Q000378:metabolism*; D015658:HIV Infections / Q000517:prevention & control; D006801:Humans; D019668:Liliaceae; D037241:Mannose-Binding Lectins / Q000378:metabolism* / Q000627:therapeutic use; D037121:Plant Lectins / Q000378:metabolism; D011485:Protein Binding; D015728:Receptors, HIV / Q000378:metabolism; D054788:Ribosome Inactivating Proteins / Q000378:metabolism; D013601:T-Lymphocytes / Q000821:virology
chemical_list: D019380:Anti-HIV Agents; D003470:Culture Media; D005456:Fluorescent Dyes; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; D037241:Mannose-Binding Lectins; D037121:Plant Lectins; D015728:Receptors, HIV; C063117:snowdrop lectin; D054788:Ribosome Inactivating Proteins; D016650:Fluorescein-5-isothiocyanate