title: Combining BRAF(V) (600E) inhibition with modulators of the mitochondrial bioenergy metabolism to overcome drug resistance in metastatic melanoma.
authors: Department of Dermatology, University Hospital Essen, Essen, Germany.
authors: Elisabeth
authors: E
authors: Livingstone
authors: GlaxoSmithKline, Collegeville, PA, USA.
authors: Suzanne
authors: S
authors: Swann
authors: GlaxoSmithKline GmbH & Co. KG, Munich, Germany.
authors: Carmen
authors: C
authors: Lilla
authors: Department of Dermatology, University Hospital Essen, Essen, Germany.
authors: Dirk
authors: D
authors: Schadendorf
authors: Department of Dermatology, University Hospital Essen, Essen, Germany.
authors: Alexander
authors: A
authors: Roesch
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000008:administration & dosage; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004357:Drug Synergism; D006801:Humans; D006834:Hydrazines / Q000008:administration & dosage; D007093:Imidazoles / Q000008:administration & dosage; D007211:Indoles / Q000008:administration & dosage; D008545:Melanoma / Q000188:drug therapy* / Q000378:metabolism; D008687:Metformin / Q000008:administration & dosage; D008928:Mitochondria / Q000378:metabolism; D010085:Oxidative Phosphorylation; D010091:Oximes / Q000008:administration & dosage; D010629:Phenformin / Q000008:administration & dosage; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013449:Sulfonamides / Q000008:administration & dosage; D000077484:Vemurafenib
chemical_list: D006834:Hydrazines; D007093:Imidazoles; D007211:Indoles; D010091:Oximes; D013449:Sulfonamides; D001569:Benzodiazepines; D000077484:Vemurafenib; C512195:elesclomol; D008687:Metformin; D010629:Phenformin; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; C468549:Bz-423; C561627:dabrafenib
keywords: melanoma; mitochondria; oxidative phosphorylation; phenformin; resistance