title: Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates.
abstract: The 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with O-benzylquercetin alkynes (5-7) to afford regioselective triazole-linked O-benzylquercetin glycoconjugates (8-10) was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates (8-10) were evaluated for anti-leishmanial activity against the promastigotes and amastigotes of Leishmania donovani. Graphical Abstract Click Inspired Synthesis of Antileishmanial Triazolyl O-Benzylquercetin Glycoconjugates.
authors: Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi, 221005, India.
authors: Pratibha
authors: P
authors: Dwivedi
authors: Kunj B
authors: KB
authors: Mishra
authors: Bhuwan B
authors: BB
authors: Mishra
authors: Nisha
authors: N
authors: Singh
authors: Rakesh K
authors: RK
authors: Singh
authors: Vinod K
authors: VK
authors: Tiwari
mesh_terms: D000818:Animals; D002460:Cell Line / Q000187:drug effects; D057930:Click Chemistry; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007893:Leishmania donovani / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D011794:Quercetin / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D014230:Triazoles; D014344:Trypanocidal Agents; D011794:Quercetin