title: Acute appendicitis in acute leukemia and the potential role of decitabine in the critically ill patient.
abstract: Acute appendicitis in children with acute leukemia is uncommon and often recognized late. Immunocompromised host state coupled with the importance of avoiding treatment delays makes management additionally challenging. Leukemic infiltration of the appendix though rare must also be considered. Although successful conservative management has been reported, surgical intervention is required in most cases. We present our experience with acute appendicitis in children with acute leukemia and a case of complete remission of acute myeloid leukemia with a short course of decitabine. Decitabine may serve as bridging therapy in critically ill patients who are unable to undergo intensive chemotherapy.
authors: Division of Pediatric Hematology-Oncology, Mayo Clinic, 200 First Street S.W., Rochester, MN, USA.
authors: Deepti
authors: D
authors: Warad
authors: Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
authors: Mira A
authors: MA
authors: Kohorst
authors: Department of Pediatric Hematology-Oncology, The Aga Khan University Hospital, Karachi, Pakistan.
authors: Sadaf
authors: S
authors: Altaf
authors: Division of Pediatric Surgery, Mayo Clinic, Rochester, MN, USA.
authors: Michael B
authors: MB
authors: Ishitani
authors: Division of Pediatric Hematology-Oncology, Mayo Clinic, 200 First Street S.W., Rochester, MN, USA.
authors: Shakila
authors: S
authors: Khan
authors: Division of Pediatric Hematology-Oncology, Mayo Clinic, 200 First Street S.W., Rochester, MN, USA.
authors: Vilmarie
authors: V
authors: Rodriguez
authors: Division of Pediatric Hematology-Oncology, Mayo Clinic, 200 First Street S.W., Rochester, MN, USA.
authors: Amulya A
authors: AA
authors: Nageswara Rao
keywords: Acute appendicitis; Acute leukemia; Decitabine; Management