title: MDR1 C3435T and C1236T polymorphisms: association with high-risk childhood acute lymphoblastic leukemia.
abstract: BACKGROUND
  MDR1, one of the most important drug-transporter genes, encodes P- glycoprotein (P-gp)-a transporter involved in protecting against xenobiotics and multi-drug resistance. The significance of the genetic background in childhood acute lymphoblastic leukemia (ALL) is not well understood.
  
  
  METHODS
  To evaluate whether C3435T and C1236T MDR1 polymorphisms are associated with the occurrence and outcome of ALL, 208 children with ALL (median age 5.0 yr) and 101 healthy Thai children were studied by polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) assay.
  
  
  RESULTS
  C3435T and C1236T MDR1 polymorphism are significantly associated with the high-risk group (OR=2.6, 95%CI=1.164-5.808; P=0.028 and OR=2.231, 95%CI=1.068-4.659; p=0.047, respectively), indicating that both may be candidates for molecular markers in the high-risk group of ALL.
authors: Pathobiology Unit, Department of Biomedical Science, Faculty of Science, Rangsit University, Pathumthani, Thailand E-mail : wanida.po@rsu.ac.th.
authors: Wanida
authors: W
authors: Pongstaporn
authors: Samart
authors: S
authors: Pakakasama
authors: Panee
authors: P
authors: Chaksangchaichote
authors: Tanett
authors: T
authors: Pongtheerat
authors: Suradej
authors: S
authors: Hongeng
authors: Songsak
authors: S
authors: Permitr
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000293:Adolescent; D044466:Asian People; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D018432:Drug Resistance, Multiple / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B