title: Myeloid and lymphoid neoplasm with abnormalities of FGFR1 presenting with trilineage blasts and RUNX1 rearrangement: a case report and review of literature.
abstract: OBJECTIVE
  Myeloid and lymphoid neoplasms with abnormalities of fibroblast growth factor receptor 1 gene (FGFR1) are a rare and aggressive disease group that harbors translocations of FGFR1 with at least 14 recognized partner genes. We report a case of a patient with a novel t(17;21)(p13;q22) with RUNX1 rearrangement and trilineage blasts.
  
  
  METHODS
  A 29-year-old man with relapsed T-lymphoblastic lymphoma in the cervical nodes showed a myeloproliferative neoplasm in his bone marrow with three separate populations of immunophenotypically aberrant myeloid, T-lymphoid, and B-lymphoid blasts by flow cytometry. Cytogenetic and fluorescent in situ hybridization studies showed unique dual translocations of t(8;13)(p11.2;q12) and t(17;21)(p13;q22) with RUNX1 rearrangement.
  
  
  RESULTS
  The patient was initiated on a mitoxantrone, etoposide, and cytarabine chemotherapy regimen and died of complications of disease 1 month later.
  
  
  CONCLUSIONS
  To our knowledge, this is the first reported case of a myeloid and lymphoid neoplasm with abnormalities of FGFR1 with t(17;21)(p13;q22) and trilineage blasts.
authors: From the Department of Pathology, University of Texas Southwestern Medical Center, Dallas.
authors: Kirthi R
authors: KR
authors: Kumar
authors: From the Department of Pathology, University of Texas Southwestern Medical Center, Dallas.
authors: Weina
authors: W
authors: Chen
authors: From the Department of Pathology, University of Texas Southwestern Medical Center, Dallas.
authors: Prasad R
authors: PR
authors: Koduru
authors: From the Department of Pathology, University of Texas Southwestern Medical Center, Dallas. Hung.Luu@childrens.com.
authors: Hung S
authors: HS
authors: Luu
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D017809:Fatal Outcome; D015321:Gene Rearrangement; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; C493728:RUNX1 protein, human; C496348:FGFR1 protein, human; D051496:Receptor, Fibroblast Growth Factor, Type 1
keywords: Eosinophilia; FGFR1; Hematopoietic; Lymphoid; Myeloproliferative; Neoplasm; RUNX1; ZMYM2