title: Serum Visfatin, Fetuin-A, and Pentraxin 3 Levels in Patients With Psoriasis and Their Relation to Disease Severity.
abstract: BACKGROUND
  Psoriasis is a chronic immune-mediated inflammatory skin disease associated with increase of some pro-inflammatory mediators. We wanted to investigate whether there is a relationship between psoriasis and visfatin, fetuin-A and pentraxin 3 (PTX3)-pro-inflammatory mediators implicated in the development of insulin resistance (IR), metabolic syndrome, and atherosclerosis.
  
  
  METHODS
  Visfatin, fetuin-A, and PTX3 concentrations were measured in 45 patients with plaque-type psoriasis and 45 healthy controls using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Serum levels of visfatin, fetuin-A, and PTX3 in patients with psoriasis were found to be higher than in healthy controls (P = 0.002, P = 0.009, P < 0.001, respectively). Psoriasis area and severity index (PASI) score correlated significantly with visfatin and fetuin-A levels (P = 0.011, P = 0.040, respectively). There was a significant positive correlation between visfatin and fetuin-A (P < 0.001). PTX3 levels were correlated positively with homeostasis model assessment (HOMA-IR), insulin, triglyceride (TG), and very low density lipoprotein cholesterol (VLDL; P = 0.009, P = 0.007, P = 0.023, P = 0.024, respectively).
  
  
  CONCLUSIONS
  Increased serum visfatin, fetuin-A, and PTX3 levels, and the presence of positive correlation between visfatin, fetuin-A, and PASI score, probably reflect the inflammatory state and IR seen in psoriasis.
authors: Dermatology Department, Kemerburgaz University, Istanbul.
authors: Gökhan
authors: G
authors: Okan
authors: Istanbul Faculty of Medicine, Department of Biochemistry, Istanbul University, Istanbul.
authors: Adile Merve
authors: AM
authors: Baki
authors: Department of Biochemistry, Medical Park Bahçelievler Hospital, Istanbul.
authors: Eda
authors: E
authors: Yorulmaz
authors: Istanbul Faculty of Medicine, Department of Biochemistry, Istanbul University, Istanbul.
authors: Semra
authors: S
authors: Doğru-Abbasoğlu
authors: Istanbul Faculty of Medicine, Department of Biochemistry, Istanbul University, Istanbul.
authors: Pervin
authors: P
authors: Vural
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016014:Linear Models; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011565:Psoriasis / Q000097:blood* / Q000473:pathology*; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D012720:Severity of Illness Index; D055815:Young Adult; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein; D016207:Cytokines; D007328:Insulin; D008055:Lipids; D054409:Nicotinamide Phosphoribosyltransferase; D000683:Serum Amyloid P-Component; D060749:alpha-2-HS-Glycoprotein; D000099153:Pentraxins; C085455:nicotinamide phosphoribosyltransferase, human
keywords: fetuin-A; inflammation; insulin resistance; pentraxin 3; psoriasis; visfatin