title: Circadian cycle-dependent MeCP2 and brain chromatin changes.
abstract: Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein of the brain, very abundant especially in neurons, where it plays an important role in the regulation of gene expression. Hence it has the potential to be affected by the mammalian circadian cycle. We performed expression analyses of mice brain frontal cortices obtained at different time points and we found that the levels of MeCP2 are altered circadianly, affecting overall organization of brain chromatin and resulting in a circadian-dependent regulation of well-stablished MeCP2 target genes. Furthermore, this data suggests that alterations of MeCP2 can be responsible for the sleeping disorders arising from pathological stages, such as in autism and Rett syndrome.
authors: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.
authors: Alexia
authors: A
authors: Martínez de Paz
authors: Jose Vicente
authors: JV
authors: Sanchez-Mut
authors: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.
authors: Mireia
authors: M
authors: Samitier-Martí
authors: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.
authors: Paolo
authors: P
authors: Petazzi
authors: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.
authors: Mauricio
authors: M
authors: Sáez
authors: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.
authors: Karolina
authors: K
authors: Szczesna
authors: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.
authors: Dori
authors: D
authors: Huertas
authors: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.
authors: Manel
authors: M
authors: Esteller
authors: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain; Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.
authors: Juan
authors: J
authors: Ausió
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D056926:CLOCK Proteins / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D002940:Circadian Rhythm / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D051783:Methyl-CpG-Binding Protein 2 / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D002843:Chromatin; D051783:Methyl-CpG-Binding Protein 2; D056926:CLOCK Proteins