title: Plasma levels of glucagon-like peptide 1 and markers of obesity among young and healthy adults.
abstract: OBJECTIVE
  Glucagon-like peptide 1 (GLP-1)-related pathways may partially explain the strong relationship between obesity and type 2 diabetes. We therefore aimed to evaluate the relationships between fasting GLP-1 levels, body fat mass and other obesity markers in a large sample of young and healthy adults.
  
  
  METHODS
  Our population-based study included 2096 individuals aged 24-44. Exclusion criteria were prevalent cardiovascular disease, diabetes or a body mass index (BMI) >35 kg/m(2) . Body fat mass was obtained by bioelectrical impedance analysis. Multivariable linear regression models were constructed to assess the relationships of GLP-1 with various measures of body composition.
  
  
  RESULTS
  Median age of our population was 37 years, median BMI 24·1 kg/m(2) and median body fat 25·1%. A strong positive correlation was observed in age-adjusted models between GLP-1 and fat mass in men (β (95% confidence interval) 1·38 (0·69; 2·07), P < 0·001) and women (1·27 (0·65; 1·89), P < 0·001) as well as fully adjusted models including BMI in men [0·87 (0·27; 1·46), P < 0·01] but not women [0·29 (-0·07; 0·64), P = 0·11]. The relationships of GLP-1 with BMI for men and women [0·00 (-0·34; 0·34), P = 0·99] [-0·02 (-0·28; 0·25), P = 0·91] and waist circumference [0·43 (-0·45; 1·30), P = 0·34] [0·37 (-0·44; 1·18), P = 0·37], respectively, were not significant after multivariable adjustment including fat mass.
  
  
  CONCLUSIONS
  Among young and healthy adults, GLP-1 levels are strongly and independently related to body fat mass especially in men but not BMI or waist circumference. These results raise the hypothesis that GLP-1 may be implicated in body fat mass regulation.
authors: Department of Medicine, University Hospital Basel, Basel, Switzerland.|Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
authors: Jan Gerrit
authors: JG
authors: van der Stouwe
authors: Department of Medicine, University Hospital Basel, Basel, Switzerland.|Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
authors: Stefanie
authors: S
authors: Aeschbacher
authors: Department of Medicine, University Hospital Basel, Basel, Switzerland.|Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
authors: Philipp
authors: P
authors: Krisai
authors: Department of Medicine, University Hospital Basel, Basel, Switzerland.|Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
authors: Tobias
authors: T
authors: Schoen
authors: Department of Medicine, University Hospital Basel, Basel, Switzerland.|Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
authors: Pascal
authors: P
authors: Meyre
authors: Singulex, Inc., Alameda, CA, USA.
authors: John
authors: J
authors: Todd
authors: Singulex, Inc., Alameda, CA, USA.
authors: Joel
authors: J
authors: Estis
authors: Labormedizinisches Zentrum Dr. Risch, Schaan, Liechtenstein.|Division of Laboratory Medicine, Kantonspital Graubünden, Chur, Switzerland.
authors: Martin
authors: M
authors: Risch
authors: Labormedizinisches Zentrum Dr. Risch, Schaan, Liechtenstein.|Division of Clinical Biochemistry, Medical University Innsbruck, Innsbruck, Austria.|Private University, Triesen, Liechtenstein.
authors: Lorenz
authors: L
authors: Risch
authors: Department of Medicine, University Hospital Basel, Basel, Switzerland.|Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
authors: David
authors: D
authors: Conen
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000097:blood*; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood*; D055105:Waist Circumference
chemical_list: D052216:Glucagon-Like Peptide 1