title: Neuroimmune mechanisms in cancer pain.
abstract: OBJECTIVE
  The current review provides a summary of recent advances in our understanding of the neuroimmune interactions which influence the development of pain associated with cancer.
  
  
  RESULTS
  Common signalling pathways, mediators and immune cell types are involved in the generation of pain as a result of both cancer and its treatment. Distinct alterations in central and peripheral neuronal function occur in multiple forms of cancer pain. Other more unusual neuroimmune processes such as graft-versus-host disease may cause cancer pain.
  
  
  CONCLUSIONS
  Identification of the cellular processes which underlie the generation of cancer pain provide potential novel targets for drug development and may eventually lead to improved pain management for cancer patients.
authors: aThe Royal Marsden Hospital, London, UK bThe Institute of Cancer Research, Sutton, Surrey, UK cNuffield Department of Clinical Neurosciences, John Radcliffe Hospital University of Oxford, Headington, Oxford, UK.
authors: Matthew R D
authors: MR
authors: Brown
authors: Juan D
authors: JD
authors: Ramirez
mesh_terms: D059787:Acute Pain / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000276:immunology / Q000503:physiopathology* / Q000556:secondary; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D009437:Neuralgia / Q000139:chemically induced / Q000209:etiology / Q000276:immunology*; D015213:Neuroimmunomodulation / Q000502:physiology*; D010149:Postoperative Pain / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D017933:Peripheral Nervous System / Q000276:immunology / Q000503:physiopathology; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents