title: Treatment of hemorrhagic gastritis by Ankaferd blood stopper versus Omeprazole: experimental randomized rat models.
abstract: BACKGROUND
  Ankaferd blood stopper (ABS) is a herbal extract that enhances mucosal healing. It has therapeutic potential in the management of external hemorrhage and controlling gastrointestinal bleeding associated with various benign lesions refractory to conventional antihemorrhagic measures. The aim of this experimental study was to assess the effects of ABS on hemorrhagic lesions and compare them with omeprazole.
  
  
  METHODS
  The study was conducted on 30 rats. Rats were divided into five groups: group A (only indomethacin), group B (ABS administration 60 min before indomethacin-induced injury), group C (ABS administration 30 min after indomethacin-induced injury), group D (omeprazole administration 60 min before indomethacin-induced injury), group E (omeprazole administration 30 min after indomethacin-induced injury). Gastric mucosal lesions were produced by indomethacin in all three groups. The effect was studied morphologically 6 h after oral administration of the drug. Subsequently, affected tissue was examined histologically.
  
  
  RESULTS
  Based on the number and the total size of hemorrhagic lesions, the hemorrhagic lesion scores were significantly better in Group C compared to other groups (p < 0.05). The hemorrhagic lesion score of Group B was significantly better than Group D and Group A (p < 0.05). Omeprazole groups (Group D, Group E) did not show significant improvement as indicated by macroscopic scores. There was no significant difference between the groups with respect to microscopic scores.
  
  
  CONCLUSIONS
  These results indicate that ABS has a potent inhibitory action on indomethacin-induced gastric bleeding and mucosal lesions and it is useful in the treatment of acute gastric mucosal lesions.
authors: Deparment of Internal Medicine, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Hikmetullah
authors: H
authors: Batgi
authors: Department of Gastroenterology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors: Erdem
authors: E
authors: Akbal
authors: Department of Gastroenterology, Çanakkale state Hospital, Çanakkale, Turkey.
authors: Erdem
authors: E
authors: Koçak
authors: Department of Internal Medicine, Mevlana University Faculty of Medicine, Konya, Turkey. dromerakyurek@gmail.com.
authors: Ömer
authors: Ö
authors: Akyürek
authors: Department of Gastroenterology, School of medicine Hacettepe University, Ankara, Turkey.
authors: Seyfettin
authors: S
authors: Köklü
authors: Department of Pathology, Ankara Education and Research Hospital, Ankara, Turkey.
authors: Melahat
authors: M
authors: Dönmez
authors: Department of Internal Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors: Fahri
authors: F
authors: Güneş
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D005756:Gastritis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology*; D006490:Hemostatics / Q000008:administration & dosage; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage*; D010936:Plant Extracts / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper; D009853:Omeprazole
keywords: Ankaferd blood stopper; Hemorrhagic gastritis; Omeprazole