title: The hypocholesterolemic and hormone modulation effects of isoflavones alone or co-fermented with probiotic bacteria in hypercholesterolemic rats model.
abstract: This study aimed to investigate the beneficial effect of isoflavones alone or probiotics-co-fermented isoflavones on serum and hepatic lipid profile, serum steroid (SHs) and thyroid hormones (THs) of hypercholesterolemic rats (N = 48). Animals were fed for 8 weeks with probiotics-co-fermented isoflavones or isoflavones alone, beside high-fat-high-cholesterol diet. Serum was analyzed for cholesterols, triglycerides (TG), SHs and THs. Results demonstrated that the given treatments significantly decreased serum total-cholesterol (TC), low-density-lipoprotein-cholesterol (LDL-C), high-density-lipoprotein-cholesterol (HDL-C), LDL/HDL ratio, and increased TG, compared to controls. The probiotics-co-fermented isoflavones decreased TC, LDL-C and LDL/HDL ratio more effectively than isoflavones alone. Also, both isoflavones treatments induced a hyperthyroidism state, as the levels of T-T4, T-T3 and fT3 significantly increased. In addition, these treatments decreased testosterone and increased cortisol levels. Thus, isoflavones-containing-treatments, particularly probiotics-co-fermented isoflavones, could reduce CVD incidence by controlling lipid profile; and this control could in part be due to modulation of SHs and THs.
authors: Faculty of Agriculture, Jordan University of Science and Technology , Irbid , Jordan .
authors: Taha M
authors: TM
authors: Rababah
authors: Saddam S
authors: SS
authors: Awaisheh
authors: Hosam J
authors: HJ
authors: Al-Tamimi
authors: Susan
authors: S
authors: Brewer
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001419:Bacteria; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D005285:Fermentation; D006854:Hydrocortisone / Q000097:blood*; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D007529:Isoflavones / Q000494:pharmacology / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D019936:Probiotics / Q000627:therapeutic use*; D017207:Rats, Sprague-Dawley; D013256:Steroids / Q000097:blood; D013739:Testosterone / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007529:Isoflavones; D010936:Plant Extracts; D013256:Steroids; D013963:Thyroid Hormones; D014280:Triglycerides; D013739:Testosterone; D002784:Cholesterol; D006854:Hydrocortisone
keywords: Hypercholesterolemia; isoflavones; probiotics; steroids; symbiotic; thyroid