title: Late onset multiple sclerosis: Is it really late onset?
abstract: BACKGROUND
  Multiple sclerosis (MS) is the most common demyelinating disease, and onset over the age of 50 years is referred to as late onset MS (LOMS). It has been thought that LOMS patients will be more likely to exhibit a primary progressive (PPMS) clinical course.
  
  
  OBJECTIVE
  To identify the clinical characteristics of demyelinating disease in patients over the age of 50 years from four different MS centers in the Northern Midwest USA.
  
  
  METHODS
  We reviewed medical records of all patients seen at the MS centers and identified those who were 50 years of age or more at the time of first spontaneously reported symptoms. We included those who were diagnosed with MS or clinically isolated syndrome (CIS) and excluded MS mimickers. Demographics, initial clinical course diagnosis, clinical characteristics, and any available five-year follow up data were collected. The clinical course was reevaluated in each patient with careful questioning regarding any prior focal neurological symptoms that had persisted for at least 48h, not otherwise explained. Those with a prior event who were initially diagnosed with PPMS or CIS were reclassified as secondary-progressive MS (SPMS) and relapsing-remitting MS (RRMS) respectively.
  
  
  RESULTS
  We identified 124 patients from a total of 3700 patients, making LOMS 3.4% MS in our population. The initial clinical course was RRMS in 50 (40%), PPMS in 44 (36%), SPMS in 15 (12%), and CIS in 15 (12%) patients. After reclassification the clinical course was RRMS in 55 (44%), PPMS in 25 (20%), SPMS in 34 (28%), and CIS in 10 (8%) patients. The clinical syndrome was identified as acute for 77 patients (62%) with transverse myelitis (N=25, 32%) as the most common type. The clinical syndrome was chronic for 47 patients (37%) and again transverse myelitis (N=24, 51%) was the most common type. Five-year follow up data was available for 44% of these patients.
  
  
  CONCLUSIONS
  LOMS is rare and RRMS is the most common clinical course. Reclassification of the clinical course, not done before in any other LOMS study, with careful questioning regarding a prior neurological event reveals that SPMS is the most common type of progressive MS and PPMS may be less common than previously thought. Transverse myelitis is the most common clinical presentation.
authors: Department of Neurology, University of Minnesota, 420 Delaware Street SE, MMC 295, Minneapolis, MN 55455, United States. Electronic address: rooha002@umn.edu.
authors: Pezhman
authors: P
authors: Roohani
authors: Department of Neurology, University of Minnesota, 420 Delaware Street SE, MMC 295, Minneapolis, MN 55455, United States. Electronic address: tenbit99@gmail.com.
authors: Tenbit
authors: T
authors: Emiru
authors: Department of Neurology, University of Minnesota, 420 Delaware Street SE, MMC 295, Minneapolis, MN 55455, United States. Electronic address: carpe004@umn.edu.
authors: Adam
authors: A
authors: Carpenter
authors: Department of Neurology, University of Wisconsin, 20 South Park, Madison, WI 53715, United States. Electronic address: Luzzio@neurology.wisc.edu.
authors: Christopher
authors: C
authors: Luzzio
authors: Sanford Clinic Neurology, School of Medicine of the University of South Dakota, 1210 W 18th Street, Suite 101, Sioux Falls, SD 57104, United States. Electronic address: Jerome.freeman@usd.edu.
authors: Jerome
authors: J
authors: Freeman
authors: Sanford Neuroscience Center, 700 1st Avenue S, Fargo, ND 58103, United States. Electronic address: Susan.Scarberry@sanfordhealth.org.
authors: Susan
authors: S
authors: Scarberry
authors: Department of Neurology, University of Minnesota, 420 Delaware Street SE, MMC 295, Minneapolis, MN 55455, United States.
authors: Gary
authors: G
authors: Beaver
authors: Mankato Clinic, Department of Neurology, 1230 E Main, Mankato, MN 56002, United States.
authors: Lisa
authors: L
authors: Davidson
authors: Department of Neurology, University of Minnesota, 420 Delaware Street SE, MMC 295, Minneapolis, MN 55455, United States. Electronic address: parry001@umn.edu.
authors: Gareth
authors: G
authors: Parry
keywords: Demyelinating disease in the elderly; Late onset multiple sclerosis; Multiple sclerosis