title: [Lethal intoxication with baclofen].
abstract: The objective of the present study was to select and develop simpler methods for the quantitative determination of baclofen in blood with the use of HPLC and tandem MS (MS-MS) techniques and its qualitative determination in cadaveric organs by the GC/MS technique. These mathods were shown to be suitable for the purpose of forensic medical analysis, clinical, toxicological, and therapeutic monitoring. The special emphasis is laid on the methods used to investigate the biological materials obtained from the subjects who died from baclofen intoxication.
authors: Krasnojarskoe kraevoe bjuro sudebno-meditsinskoj ekspertizy Sibirskogo federal'nogo universiteta, Krasnojarsk, Rossija, 660041.
authors: O A
authors: OA
authors: Dukova
authors: Tsentral'naja nauchno-issledovatel'skaja laboratorija Krasnojarskogo gosudarstvennogo meditsinskogo universiteta im. prof. V.F. Vojno-Jasenetskogo Minzdrava Rossii, Krasnojarsk, Rossija, 660022.
authors: A A
authors: AA
authors: Pokrovskij
authors: Cheljabinskoe oblastnoe bjuro sudebno-meditsinskoj ekspertizy, Cheljabinsk, Rossija, 454076.
authors: A B
authors: AB
authors: Melent'ev
authors: kafedra farmatsevticheskoj himii Sibirskogo gosudarstvennogo meditsinskogo universiteta, Tomsk, Rossija, 634050.
authors: E A
authors: EA
authors: Krasnov
authors: Krasnojarskoe kraevoe bjuro sudebno-meditsinskoj ekspertizy, Krasnojarsk, Rossija, 660049.
authors: E V
authors: EV
authors: Suvorova
authors: kafedra analiticheskoj i organicheskoj himii Sibirskogo federal'nogo universiteta, Krasnojarsk, Rossija, 660041.
authors: A A
authors: AA
authors: Efremov
mesh_terms: D000328:Adult; D001418:Baclofen / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning; D002851:Chromatography, High Pressure Liquid; D017809:Fatal Outcome; D005260:Female; D053593:Forensic Toxicology / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D057230:Limit of Detection; D008099:Liver / Q000378:metabolism; D009125:Muscle Relaxants, Central / Q000032:analysis* / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning; D011041:Poisoning / Q000097:blood / Q000209:etiology / Q000378:metabolism; D015203:Reproducibility of Results; D013405:Suicide; D053719:Tandem Mass Spectrometry; D014018:Tissue Distribution
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen