title: Healthy term and moderately preterm infants have similar cerebral oxygen saturation and cerebral blood flow volumes during early post-natal transition.
abstract: OBJECTIVE
  This pilot study evaluated changes in regional cerebral oxygen saturation and cerebral blood flow volume during the transitional period in healthy term and moderately preterm infants.
  
  
  METHODS
  The cohort comprised 16 preterm infants and seven full-term infants with mean gestational ages of 34 and 39 weeks, respectively. Longitudinal measurements were conducted during the first three days after birth. Regional cerebral oxygen saturation was determined bilaterally by frequency domain near-infrared spectroscopy. Flow volumes were determined in internal carotid and vertebral arteries by multiplying the time-averaged velocity by the cross-sectional area: cerebral blood flow volume was calculated as the sum of flow volumes and adjusted for brain weight.
  
  
  RESULTS
  Brain weight-adjusted cerebral blood flow volumes and regional cerebral oxygen saturation were similar in preterm and term infants. Regional cerebral oxygen saturation did not correlate with brain weight-adjusted cerebral blood flow volume. Right and left brain weight-adjusted internal carotid flow volumes did not correlate with right and left regional cerebral oxygen saturation.
  
  
  CONCLUSIONS
  Our findings suggest that during the first three days after birth there was adequate cardiorespiratory adaptation, cerebral perfusion and adequate compensation through the arterial circle of Willis in both healthy term and moderately preterm infants.
authors: Department of Neonatology, University Children's Hospital Tuebingen, Tuebingen, Germany.
authors: A
authors: A
authors: Demel
authors: Department of Neonatology, University Children's Hospital Tuebingen, Tuebingen, Germany.
authors: K
authors: K
authors: Feilke
authors: Department of Neuropediatrics, University Children's Hospital Tuebingen, Tuebingen, Germany.
authors: M
authors: M
authors: Schöning
authors: Biomedical Optics Research Laboratory, Division of Neonatology, University Hospital Zurich, Zurich, Switzerland.
authors: M
authors: M
authors: Wolf
authors: Department of Neonatology, University Children's Hospital Tuebingen, Tuebingen, Germany.
authors: C F
authors: CF
authors: Poets
authors: Department of Neonatology, University Children's Hospital Tuebingen, Tuebingen, Germany.
authors: A R
authors: AR
authors: Franz
mesh_terms: D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008137:Longitudinal Studies; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010865:Pilot Projects; D011446:Prospective Studies; D047929:Term Birth; D013997:Time Factors
chemical_list: D010100:Oxygen
keywords: Cerebral blood flow volume; Cerebral oxygen saturation; Near-infrared spectroscopy; Preterm infants; Term infants