title: NK-1 Antagonists and Itch.
abstract: Substance P (SP) is an important mediator of pro-inflammatory mechanisms in the skin. It targets multiple cells such as keratinocytes, mast cells, and fibroblasts which are involved in the cutaneous generation of pruritus. This suggests that SP is an interesting target for therapy. In fact, in recent case reports and case series, SP antagonists demonstrated a significant antipruritic effect in acute and chronic pruritus such as drug-induced pruritus, paraneoplastic pruritus, prurigo nodularis, cutaneous T-cell lymphoma, and brachioradial pruritus.
authors: Department of Dermatology, Competence Center Chronic Pruritus, University Hospital of Münster, Von-Esmarch-Strasse 58, 48149, Münster, Germany, sonja.staender@uni-muenster.de.
authors: Sonja
authors: S
authors: Ständer
authors: Thomas A
authors: TA
authors: Luger
mesh_terms: D000818:Animals; D000077608:Aprepitant; D006801:Humans; D009025:Morpholines / Q000009:adverse effects / Q000627:therapeutic use*; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D018040:Receptors, Neurokinin-1 / Q000502:physiology*; D013373:Substance P / Q000037:antagonists & inhibitors* / Q000502:physiology
chemical_list: D009025:Morpholines; D018040:Receptors, Neurokinin-1; D000077608:Aprepitant; D013373:Substance P