title: Metformin-clinical pharmacology in PCOs.
abstract: Oligo-anovulation, hyperandrogenism and insulin resistance characterizes polycystic ovary syndrome (PCOs). Metformin is the oldest insulin sensitizer used in the management of type 2 diabetes mellitus. In PCOs, metformin decreases the serum lipids, androgen and insulin; induces ovulation and regular menstrual cycle; increases the pregnancy rate.
authors: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Gynecology Department, "Dr. I. Cantacuzino Hospital", Bucharest, Romania.
authors: R
authors: R
authors: Dumitrescu
authors: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; Gynecology Department, "Nicolae Malaxa Hospital", Bucharest, Romania.
authors: C
authors: C
authors: Mehedintu
authors: Gynecology Department, "Dr. I. Cantacuzino Hospital", Bucharest, Romania.
authors: I
authors: I
authors: Briceag
authors: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors: V L
authors: VL
authors: Purcărea
authors: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors: D
authors: D
authors: Hudita
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism; D005260:Female; D006801:Humans; D008687:Metformin / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D012098:Reproduction / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D008687:Metformin; D000263:Adenylate Kinase
keywords: PCOs; diabetes mellitus; infertility; insulin resistance; metformin