title: Multifunctional polymer-capped mesoporous silica nanoparticles for pH-responsive targeted drug delivery.
abstract: A highly stable modular platform, based on the sequential covalent attachment of different functionalities to the surface of core-shell mesoporous silica nanoparticles (MSNs) for targeted drug delivery is presented. A reversible pH-responsive cap system based on covalently attached poly(2-vinylpyridine) (PVP) was developed as drug release mechanism. Our platform offers (i) tuneable interactions and release kinetics with the cargo drug in the mesopores based on chemically orthogonal core-shell design, (ii) an extremely robust and reversible closure and release mechanism based on endosomal acidification of the covalently attached PVP polymer block, (iii) high colloidal stability due to a covalently coupled PEG shell, and (iv) the ability to covalently attach a wide variety of dyes, targeting ligands and other functionalities at the outer periphery of the PEG shell. The functionality of the system was demonstrated in several cell studies, showing pH-triggered release in the endosome, light-triggered endosomal escape with an on-board photosensitizer, and efficient folic acid-based cell targeting.
authors: Department of Chemistry, Nanosystems Initiative Munich (NIM) and Center for Nano Science (CeNS), University of Munich (LMU), Butenandtstr. 11 (E), 81377 Munich, Germany. bein@lmu.de Christoph.Braeuchle@cup.uni-muenchen.de.
authors: Stefan
authors: S
authors: Niedermayer
authors: Veronika
authors: V
authors: Weiss
authors: Annika
authors: A
authors: Herrmann
authors: Alexandra
authors: A
authors: Schmidt
authors: Stefan
authors: S
authors: Datz
authors: Katharina
authors: K
authors: Müller
authors: Ernst
authors: E
authors: Wagner
authors: Thomas
authors: T
authors: Bein
authors: Christoph
authors: C
authors: Bräuchle
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics*; D005456:Fluorescent Dyes / Q000737:chemistry / Q000493:pharmacokinetics; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007624:KB Cells; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000493:pharmacokinetics; D011145:Polyvinyls / Q000737:chemistry* / Q000493:pharmacokinetics; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005456:Fluorescent Dyes; D011145:Polyvinyls; C058671:poly(2-vinylpyridine); D011092:Polyethylene Glycols; D012822:Silicon Dioxide