title: The expression and distributions of ANP32A in the developing brain.
abstract: Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A), has multiple functions involved in neuritogenesis, transcriptional regulation, and apoptosis. However, whether ANP32A has an effect on the mammalian developing brain is still in question. In this study, it was shown that brain was the organ that expressed the most abundant ANP32A by human multiple tissue expression (MTE) array. The distribution of ANP32A in the different adult brain areas was diverse dramatically, with high expression in cerebellum, temporal lobe, and cerebral cortex and with low expression in pons, medulla oblongata, and spinal cord. The expression of ANP32A was higher in the adult brain than in the fetal brain of not only humans but also mice in a time-dependent manner. ANP32A signals were dispersed accordantly in embryonic mouse brain. However, ANP32A was abundant in the granular layer of the cerebellum and the cerebral cortex when the mice were growing up, as well as in the Purkinje cells of the cerebellum. The variation of expression levels and distribution of ANP32A in the developing brain would imply that ANP32A may play an important role in mammalian brain development, especially in the differentiation and function of neurons in the cerebellum and the cerebral cortex.
authors: Weifang Medical University, Weifang 261042, China.
authors: Shanshan
authors: S
authors: Wang
authors: Department of Neurology, The 148th Hospital, Zibo 255300, China.
authors: Yunliang
authors: Y
authors: Wang
authors: Zhengzhou University, Zhengzhou 450001, China.
authors: Qingshan
authors: Q
authors: Lu
authors: Weifang Medical University, Weifang 261042, China.
authors: Xinshan
authors: X
authors: Liu
authors: Department of Neurosurgery, PLA 301 Hospital, Beijing 100853, China.
authors: Fuyu
authors: F
authors: Wang
authors: Department of Neurosurgery, PLA 301 Hospital, Beijing 100853, China.
authors: Xiaodong
authors: X
authors: Ma
authors: Center for Basic Medical Sciences, Navy General Hospital of Chinese PLA, Beijing 100048, China.
authors: Chunping
authors: C
authors: Cui
authors: Center for Basic Medical Sciences, Navy General Hospital of Chinese PLA, Beijing 100048, China.
authors: Chenghe
authors: C
authors: Shi
authors: Department of Neurology, The 148th Hospital, Zibo 255300, China.
authors: Jinfeng
authors: J
authors: Li
authors: Center for Basic Medical Sciences, Navy General Hospital of Chinese PLA, Beijing 100048, China.
authors: Dajin
authors: D
authors: Zhang
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000196:embryology*; D002454:Cell Differentiation / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009687:Nuclear Proteins / Q000096:biosynthesis*; D016601:RNA-Binding Proteins
chemical_list: C530107:Anp32a protein, mouse; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins