title: Expression profiles of MiRNAs for intrinsic musculature of the forepaw and biceps in the rat model simulating irreversible muscular atrophy of obstetric brachial plexus palsy.
abstract: Clinically in obstetric brachial plexus palsy (OBPP), irreversible atrophy of intrinsic musculature of the hand in denervation occurs much earlier than that of denervated arm muscles. With the aim of finding clues to explain this, the miRNA expression profile of denervated intrinsic musculature of the forepaw (IMF) and that of the denervated biceps were examined by microarray screening in the rat model simulating irreversible muscular atrophy caused by pan-plexus lesions of OBPP, and potential targets of specifically dysregulated miRNAs were predicted with use of bioinformatics analysis. It was found that denervated IMF and biceps had their own specifically dysregulated miRNAs, respectively, as compared with control. Analysis of Gene Ontology and of pathway showed that those specifically dysregulated miRNAs and their target genes might participate in self-regulation of neuromuscular junctions (NMJs). These outcomes suggest that self-regulative mechanism of NMJs may be different between denervated IMF and denervated biceps in the rat model simulating irreversible muscular atrophy of OBPP.
authors: Department of Hand Surgery, Wuxi Number 9 People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu Province 214062, the People's Republic of China.
authors: Feng
authors: F
authors: Pan
authors: Department of Hand Surgery, Huashan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200040, the People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai 200040, the People's Republic of China. Electronic address: liangchen1960@163.com.
authors: Liang
authors: L
authors: Chen
authors: Jiangsu Key Laboratory of Neurogeneration, Nantong University, Nantong, Jiangsu Province 226001, the People's Republic of China. Electronic address: dingfei@ntu.edu.cn.
authors: Fei
authors: F
authors: Ding
authors: Department of Hand Surgery, Huashan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200040, the People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai 200040, the People's Republic of China.
authors: Jie
authors: J
authors: Zhang
authors: Department of Hand Surgery, Huashan Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200040, the People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai 200040, the People's Republic of China.
authors: Yu-Dong
authors: YD
authors: Gu
mesh_terms: D000818:Animals; D001917:Brachial Plexus / Q000378:metabolism; D020516:Brachial Plexus Neuropathies / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D005552:Forelimb / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009133:Muscular Atrophy / Q000235:genetics* / Q000378:metabolism; D009469:Neuromuscular Junction / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D035683:MicroRNAs
keywords: Biceps; Denervation; Intrinsic musculature of the hand; MicroRNA; Neuromuscular junctions