title: [The prognostic significance of particular immunological indicators of lachrymal fluid in patients using soft contact lenses].
abstract: The study was carried out to identify concentrations of vessel epithelium growth factor (VEGF), souble forms of VEGF receptor type I and II, chemo-toxic protein I and metalloproteinase-9 in lachrymal fluid. The immune enzyme analysis was applied. He sampling included patients with myopia without complications while using silicone hydro-helium and hydro-helium contact lenses and patients with hypoxic complications of contact correction. It is established that application of hydro-helium and silicone hydro-helium contact lenses more than one year is followed by increasing of concentration of detected substances in lachrymal fluid. Under hypoxic complications of contact correction the levels of substances are significantly higher than in cases without complications. This occurrence makes it possible to substantiate possibility of application of immunologic indicators as diagnostic markers.
authors: P P
authors: PP
authors: Tereshkov
authors: M V
authors: MV
authors: Maksimenia
authors: E V
authors: EV
authors: Fefelova
authors: Iu A
authors: IuA
authors: Vitkovskiĭ
authors: T M
authors: TM
authors: Karavaeva
authors: A V
authors: AV
authors: Kozlova
mesh_terms: D000328:Adult; D001826:Body Fluids / Q000378:metabolism; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000302:isolation & purification; D009216:Myopia / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D040262:Receptors, Vascular Endothelial Growth Factor / Q000302:isolation & purification; D013666:Tears / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000302:isolation & purification
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040262:Receptors, Vascular Endothelial Growth Factor; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9