title: Let-7, mir-98 and mir-183 as biomarkers for cancer and schizophrenia [corrected].
abstract: Recent evidence supports a role of microRNAs in cancer and psychiatric disorders such as schizophrenia and bipolar disorder, through their regulatory role on the expression of multiple genes. The rather rare co-morbidity of cancer and schizophrenia is an old hypothesis which needs further research on microRNAs as molecules that might exert their oncosuppressive or oncogenic activity in the context of their role in psychiatric disorders. The expression pattern of a variety of different microRNAs was investigated in patients (N = 6) suffering from schizophrenia termed control, patients with a solid tumor (N = 10) and patients with both schizophrenia and tumor (N = 8). miRNA profiling was performed on whole blood samples using the miRCURY LNA microRNA Array technology (6th & 7th generation). A subset of 3 microRNAs showed a statistically significant differential expression between the control and the study groups. Specifically, significant down-regulation of the let-7p-5p, miR-98-5p and of miR-183-5p in the study groups (tumor alone and tumorand schizophrenia) was observed (p<0.05). The results of the present study showed that let-7, miR-98 and miR-183 may play an important oncosuppressive role through their regulatory impact in gene expression irrespective of the presence of schizophrenia, although a larger sample size is required to validate these results. Nevertheless, further studies are warranted in order to highlight a possible role of these and other micro-RNAs in the molecular pathways of schizophrenia.
authors: National and Kapodistrian University of Athens, Medical School, 2nd Department of Psychiatry, University "ATTIKON" General Hospital, Athens, Greece.
authors: Emmanouil
authors: E
authors: Rizos
authors: National and Kapodistrian University of Athens, Medical School, Microbiology Laboratory, University "ATTIKON" General Hospital, Athens, Greece.
authors: Nikolaos
authors: N
authors: Siafakas
authors: Biomedical Research Foundation, Academy of Athens, Hematology-Oncology Division, Athens, Greece.
authors: Eleni
authors: E
authors: Katsantoni
authors: Unit of Biomedical Applications, Institute of Biology, Medicinal Chemistry & Biotechnology, National Hellenic Research Foundation, Athens, Greece.
authors: Eleni
authors: E
authors: Skourti
authors: National & Kapodistrian University of Athens, 2nd Cardiology Department, University General Hospital "ATTIKON", Athens, Greece.
authors: Vassilios
authors: V
authors: Salpeas
authors: National & Kapodistrian University of Athens, 2nd Cardiology Department, University General Hospital "ATTIKON", Athens, Greece.
authors: Ioannis
authors: I
authors: Rizos
authors: Keenan Research Centre. Li Ka Shing Knowledge Institute for Biomedical Science, St. Michael's Hospital, Toronto, Canada.
authors: James N
authors: JN
authors: Tsoporis
authors: Department of Informatics, Athens University of Economics and Business, Athens, Greece.
authors: Anastasia
authors: A
authors: Kastania
authors: National and Kapodistrian University of Athens, Medical School, 2nd Department of Psychiatry, University "ATTIKON" General Hospital, Athens, Greece; Medical School, Democritus University of Thrace, University General Hospital of Alexandroupolis, Department of Psychiatry, Alexandroupolis, Greece.
authors: Anastasia
authors: A
authors: Filippopoulou
authors: Second Department of Propaedeutic Internal Medicine, Oncology Unit, Attikon University Hospital, Athens, Greece.
authors: Nikolaos
authors: N
authors: Xiros
authors: National and Kapodistrian University of Athens, Medical School, 2nd Department of Psychiatry, University "ATTIKON" General Hospital, Athens, Greece.
authors: Demetrios
authors: D
authors: Margaritis
authors: Keenan Research Centre. Li Ka Shing Knowledge Institute for Biomedical Science, St. Michael's Hospital, Toronto, Canada.
authors: Thomas G
authors: TG
authors: Parker
authors: National and Kapodistrian University of Athens, Medical School, 2nd Department of Psychiatry, University "ATTIKON" General Hospital, Athens, Greece.
authors: Charalabos
authors: C
authors: Papageorgiou
authors: Unit of Biomedical Applications, Institute of Biology, Medicinal Chemistry & Biotechnology, National Hellenic Research Foundation, Athens, Greece.
authors: Vassilios
authors: V
authors: Zoumpourlis
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D014408:Biomarkers, Tumor; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000097:blood; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000473:pathology; D012559:Schizophrenia / Q000097:blood* / Q000473:pathology
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; C533449:MIRN183 microRNA, human; C546084:MIRN98 microRNA, human; D035683:MicroRNAs; C487931:mirnlet7 microRNA, human