title: Astrocyte heterogeneity in the brain: from development to disease.
abstract: In the last decades, astrocytes have risen from passive supporters of neuronal activity to central players in brain function and cognition. Likewise, the heterogeneity of astrocytes starts to become recognized in contrast to the homogeneous population previously predicted. In this review, we focused on astrocyte heterogeneity in terms of their morphological, protein expression and functional aspects, and debate in a historical perspective the diversity encountered in glial progenitors and how they may reflect mature astrocyte heterogeneity. We discussed data that show that different progenitors may have unsuspected roles in developmental processes. We have approached the functions of astrocyte subpopulations on the onset of psychiatric and neurological diseases.
authors: Cellular Neuroanatomy Laboratory, Program in Neurobiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro Brazil.
authors: Clarissa
authors: C
authors: Schitine
authors: Cellular Neuroanatomy Laboratory, Program in Neurobiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro Brazil.
authors: Luciana
authors: L
authors: Nogaroli
authors: Laboratory of Cellular Neurobiology, Brain Institute, Federal University of Rio Grande do Norte, Natal Brazil.
authors: Marcos R
authors: MR
authors: Costa
authors: Cellular Neuroanatomy Laboratory, Program in Neurobiology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro Brazil ; Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro Brazil.
authors: Cecilia
authors: C
authors: Hedin-Pereira
keywords: astrocyte; cerebral cortex; heterogeneity; progenitors; psychiatric diseases