title: Curcumin inhibits apoptosis and brain edema induced by hypoxia-hypercapnia brain damage in rat models.
abstract: Curcumin, extracted from South Asian spice turmeric, has been determined to have the promising ability in antioxidation and anti-inflammation. However, the effect of curcumin on treating brain damage has been not reported. In this article, the aim was to evaluate the effect of curcumin on cell apoptosis in rats exposed to hypoxia-hypercapnia and explore the therapeutic potential of curcumin in hypoxia-hypercapnia brain damage (HHBD). Sprague Dawley rats were randomly assigned into 3 groups: control group, hypoxia-hypercapnia group and curcumin group. The Fas/FasL expressions in HHBD rats treated by curcumin were measured by immunohistochemical staining and western blotting. The pathological changes of brain cells were observed by transmission electron microscope. Rats with HHBD showed significant increase of Fas/FasL expression and ultrastructural changes in brain tissue cells. Curcumin intervention effectively reversed the Fas/FasL-mediated apoptosis and HHBD-induced brain edema. Curcumin may be a potential therapeutic alternative for HHBD.
authors: Xi'an Jiaotong University Health Science Center (LY, ZW), School of Forensic Science and Medicine, Xi'an, China; Department of Forensic Medicine (LY, YF, GY, JL, XF, KL, MD), Wenzhou Medical University, Wenzhou, China; and Institute of Forensic Science (LY, YF, GY, JL, XF, KL, MD), Wenzhou Medical University, Wenzhou, China.
authors: Linsheng
authors: L
authors: Yu
authors: Yanyan
authors: Y
authors: Fan
authors: Guanghua
authors: G
authors: Ye
authors: Junli
authors: J
authors: Li
authors: Xiangping
authors: X
authors: Feng
authors: Kezhi
authors: K
authors: Lin
authors: Miuwu
authors: M
authors: Dong
authors: Zhenyuan
authors: Z
authors: Wang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001929:Brain Edema / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D003474:Curcumin / Q000494:pharmacology*; D004195:Disease Models, Animal; D053222:Fas Ligand Protein / Q000096:biosynthesis; D005786:Gene Expression Regulation / Q000187:drug effects; D006935:Hypercapnia / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D000860:Hypoxia / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D019014:fas Receptor / Q000096:biosynthesis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D053222:Fas Ligand Protein; C491898:Fas protein, rat; C505662:Faslg protein, rat; D019014:fas Receptor; D003474:Curcumin