title: A vascular endothelial growth factor gene polymorphism predicts malignant potential in intraductal papillary mucinous neoplasm.
abstract: OBJECTIVE
  The aim of this study was to evaluate the clinical relevance of vascular endothelial growth factor (VEGF) single nucleotide polymorphisms (SNPs) in intraductal papillary mucinous neoplasms (IPMNs).
  
  
  METHODS
  A total of 169 IPMN and 108 pancreatic ductal adenocarcinoma patients who underwent curative resection were enrolled, and VEGF +405G/C and -460C/T SNPs were investigated.
  
  
  RESULTS
  Vascular endothelial growth factor +405C/C was found more frequently in malignant IPMNs compared with +405G/G (odds ratio [OR], 2.7; P = 0.04), and +405C allele was associated with malignant IPMNs compared with +405G (P = 0.055). In branch duct IPMNs, VEGF +405C/C was significantly associated with malignant transformation (CC vs GG: OR, 4.0; P = 0.03; CC vs CG + GG: OR, 3.3; P = 0.04), and there was a trend of VEGF +405C/C associated with malignant transformation of gastric-type IPMNs (CC vs GG: OR, 3.0; P = 0.07). When the survival outcomes were analyzed based on VEGF +405G/C SNPs, however, there was no relationship between VEGF SNPs and overall survival in patients with both IPMNs and pancreatic ductal adenocarcinomas.
  
  
  CONCLUSIONS
  Vascular endothelial growth factor +405G/C SNP was significantly associated with malignant transformation in IPMNs, especially branch duct and gastric-type IPMNs. Vascular endothelial growth factor +405G/C SNP might be helpful in predicting clinical course in pancreatic disease with potential for malignant transformation.
authors: From the *Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine; †Department of Pathology, Nagoya University Hospital; and ‡Department of Surgery, Nagoya Central Hospital, Nagoya, Japan.
authors: Norimitsu
authors: N
authors: Yabusaki
authors: Suguru
authors: S
authors: Yamada
authors: Yoshie
authors: Y
authors: Shimoyama
authors: Tsutomu
authors: T
authors: Fujii
authors: Mitsuro
authors: M
authors: Kanda
authors: Goro
authors: G
authors: Nakayama
authors: Hiroyuki
authors: H
authors: Sugimoto
authors: Masahiko
authors: M
authors: Koike
authors: Shuji
authors: S
authors: Nomoto
authors: Michitaka
authors: M
authors: Fujiwara
authors: Akimasa
authors: A
authors: Nakao
authors: Yasuhiro
authors: Y
authors: Kodera
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005260:Female; D060005:Genotyping Techniques; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A