title: Can Therapeutic Hypothermia Be Guided by Advanced Neuromonitoring in Neurocritical Care Patients? A Review.
abstract: The impact of therapeutic hypothermia (TH) on long-term neurological outcome is still controversial. Data on the effects of TH on brain homeostasis are mostly derived from experimental research. Invasive multimodal neuromonitoring techniques may provide additional insight into pathophysiological changes associated with primary or secondary brain injury in humans. In this study we describe the principles of multimodal neuromonitoring and its potential in the clinical setting of TH. We call for more research using multimodal neuromonitoring techniques in patients undergoing TH to optimize cooling and rewarming strategies.
authors: Division of Neurocritical Care, Department of Neurology, Medical University of Innsbruck , Innsbruck, Austria .
authors: Alois Josef
authors: AJ
authors: Schiefecker
authors: Division of Neurocritical Care, Department of Neurology, Medical University of Innsbruck , Innsbruck, Austria .
authors: Ronny
authors: R
authors: Beer
authors: Division of Neurocritical Care, Department of Neurology, Medical University of Innsbruck , Innsbruck, Austria .
authors: Gregor
authors: G
authors: Broessner
authors: Division of Neurocritical Care, Department of Neurology, Medical University of Innsbruck , Innsbruck, Austria .
authors: Mario
authors: M
authors: Kofler
authors: Division of Neurocritical Care, Department of Neurology, Medical University of Innsbruck , Innsbruck, Austria .
authors: Erich
authors: E
authors: Schmutzhard
authors: Division of Neurocritical Care, Department of Neurology, Medical University of Innsbruck , Innsbruck, Austria .
authors: Raimund
authors: R
authors: Helbok
mesh_terms: D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D001930:Brain Injuries / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D003422:Critical Care / Q000379:methods; D003943:Diagnostic Techniques, Neurological; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods*; D064926:Neurophysiological Monitoring / Q000379:methods*; D017063:Outcome Assessment, Health Care; D017694:Rewarming / Q000379:methods; D015599:Trauma Severity Indices