title: Impact of cardiac dysfunction on health-related quality of life in cirrhotic liver transplant candidates.
abstract: OBJECTIVE
  Cardiac dysfunction, in particular left ventricular diastolic dysfunction, is common in cirrhosis. We aimed to investigate the impact of cardiac dysfunction on health-related quality of life (QoL) in liver cirrhosis.
  
  
  METHODS
  A total of 88 cirrhotic liver transplant candidates with an available echocardiogram and ECG completed the Short form-36 (SF-36) and Fatigue Impact Scale. In a subgroup of 61 patients, levels of cardiac biomarkers, in particular serum N-terminal pro-brain natriuretic peptide, adiponectin, and high-sensitive troponin T, were also measured.
  
  
  RESULTS
  Although left ventricular systolic diameter was related to a lower SF-36 physical component summary, neither left ventricular diastolic dysfunction nor any other echocardiographic feature was found to be associated with any other SF-36 or Fatigue Impact Scale domain (P>0.05 for all). On linear regression analysis after adjustment for confounders, a prolonged QTc interval was found to be related to a lower SF-36 mental component summary score (β=-9.7, P=0.009) and increased physical fatigue (β=10.5, P=0.004). Neither serum N-terminal pro-brain natriuretic peptide, high-sensitivity troponin T, nor adiponectin levels were found to be related to QoL (P>0.05 for all). Serum adiponectin levels did not differ among patients with versus those without echocardiographic cardiac alterations (P>0.05 for all).
  
  
  CONCLUSIONS
  A prolonged QTc interval, but not any echocardiographic abnormalities or cardiac biomarkers, seems to be predictive of QoL in cirrhosis.
authors: aInstitute of Internal Medicine, Sahlgrenska Academy, University of Gothenburg bTransplant Institute, Sahlgrenska University Hospital, Gothenburg cDepartment of Gastroenterology, Skåne University Hospital, University of Lund, Lund, Sweden dDepartment of Internal Medicine, Landspitali University Hospital, Reykjavik, Iceland.
authors: Axel
authors: A
authors: Josefsson
authors: Michael
authors: M
authors: Fu
authors: Einar
authors: E
authors: Björnsson
authors: Maria
authors: M
authors: Castedal
authors: Evangelos
authors: E
authors: Kalaitzakis
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004452:Echocardiography; D004562:Electrocardiography; D005221:Fatigue / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D016014:Linear Models; D008103:Liver Cirrhosis / Q000150:complications* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000150:complications* / Q000175:diagnosis
chemical_list: D015415:Biomarkers