title: Anti-inflammatory effects of eugenol on lipopolysaccharide-induced inflammatory reaction in acute lung injury via regulating inflammation and redox status.
abstract: Acute lung injury (ALI) represents a clinical syndrome that results from complex responses of the lung to a multitude of direct and indirect insults. This study aims to evaluate the possible mechanisms responsible for the anti-inflammatory effects of eugenol (EUL) on lipopolysaccharide (LPS)-induced inflammatory reaction in ALI. ALI was induced in mice by intratracheal instillation of LPS (0.5 mg/kg), and EUL (5, and 10 mg/kg) was injected intraperitoneally 1h prior to LPS administration. After 6h, bronchoalveolar lavage fluid (BALF) and lung tissue were collected. The findings suggest that the protective mechanism of EUL may be attributed partly to decreased production of proinflammatory cytokines through the regulating inflammation and redox status. The results support that use of EUL is beneficial in the treatment of ALI.
authors: School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, PR China. Electronic address: hxfnju@163.com.
authors: Xianfeng
authors: X
authors: Huang
authors: School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, PR China.
authors: Yuanyuan
authors: Y
authors: Liu
authors: School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, PR China.
authors: Yingxun
authors: Y
authors: Lu
authors: School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, PR China. Electronic address: machunhua25@126.com.
authors: Chunhua
authors: C
authors: Ma
mesh_terms: D055371:Acute Lung Injury / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D004195:Disease Models, Animal; D005054:Eugenol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D008807:Mice, Inbred BALB C; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D008070:Lipopolysaccharides; D005054:Eugenol
keywords: Eugenol; Inflammation; Lung injury; Redox status