title: Association between the C804A polymorphism in the TGF-β gene and the risk of myocardial infarction: a meta-analysis.
abstract: Tumor necrosis factor-β (TNF-β) is an important mediator of inflammation and may play a role in the pathogenesis of myocardial infarction (MI). While several published studies have investigated the association between the C804A polymorphism in the TNF-β gene and MI risk, their results are controversial and ambiguous. In this study, we evaluated the contribution of the TNF-β C804A polymorphism to MI risk. A literature search was conducted in the PubMed, Embase, Web of Science, Cochrane Library, and Google Scholar databases to identify eligible studies published before November 1, 2013. We performed a meta-analysis of 9 case-control studies, which included a total of 19,404 MI patients and 13,684 healthy controls. Overall analysis suggested that the TNF-β C804A polymorphism was associated with a significantly increased risk of MI. Stratified analysis based on ethnicity revealed a significant association in Asian populations, but not in Caucasian populations. In conclusion, this meta-analysis revealed that the TNF-β C804A polymorphism may be associated with an increased risk of MI only in Asian populations. However, additional studies should be conducted to further confirm the association between TNF-β C804A and MI risk.
authors: Department of Emergency, the Fifth Hospital of Zhengzhou University, Zhengzhou, China suodwzd5h@126.com.
authors: D W
authors: DW
authors: Suo
authors: Department of Emergency, the Fifth Hospital of Zhengzhou University, Zhengzhou, China.
authors: Q
authors: Q
authors: Hu
authors: Department of Emergency, the Fifth Hospital of Zhengzhou University, Zhengzhou, China.
authors: J
authors: J
authors: Chen
authors: Department of Emergency, the Fifth Hospital of Zhengzhou University, Zhengzhou, China.
authors: Q H
authors: QH
authors: Sun
authors: Department of Emergency, the Fifth Hospital of Zhengzhou University, Zhengzhou, China.
authors: H
authors: H
authors: Guo
mesh_terms: D044466:Asian People / Q000235:genetics; D016208:Databases, Factual; D020022:Genetic Predisposition to Disease; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016212:Transforming Growth Factor beta / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D016212:Transforming Growth Factor beta