title: Hybrid imaging with 99mTc-WBC SPECT/CT to monitor the effect of therapy in diabetic foot osteomyelitis.
abstract: This study sought to assess the utility of monitoring response to treatment of diabetic foot osteomyelitis (DFO) with Tc-99m WBC-labelled single photon emission computed tomography (SPECT/CT) imaging. This is a retrospective cohort study of 20 patients with DFO with sequential Tc-99m WBC-labelled SPECT/CT imaging. Radiologic findings of osteomyelitis were evaluated and imaging results were correlated with clinical outcomes subtracted from chart review. Successful treatment of osteomyelitis was defined by wound healing and/or lack of re-admission for bone infection of the same site within 1 year. The sensitivity, specificity, positive predictive value and negative predictive value of SPECT/CT to determine osteomyelitis treatment remission were 90%, 56%, 69% and 83%, respectively. Tc-99m WBC-labelled SPECT/CT imaging may be useful to help determine treatment outcomes for DFO.
authors: Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Francisco
authors: F
authors: Lazaga
authors: Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Suzanne Av
authors: http://orcid.org/0000-0002-2753-4577
authors: SA
authors: Van Asten
authors: Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Adam
authors: A
authors: Nichols
authors: Department of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Kavita
authors: K
authors: Bhavan
authors: Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Javier
authors: J
authors: La Fontaine
authors: Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Orhan K
authors: OK
authors: Oz
authors: Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors: Lawrence A
authors: LA
authors: Lavery
mesh_terms: D017719:Diabetic Foot; D006801:Humans; D064847:Multimodal Imaging; D010019:Osteomyelitis; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
keywords: Diabetic foot; Imaging; Infection; Osteomyelitis; SPECT/CT