title: Interferon-λ-related genes and therapeutic response in Chinese hepatitis C patients.
abstract: OBJECTIVE
  To determine the association between rapid viral response and IL28B, IL28RA, IL10RB and MxA polymorphisms in the Chinese Han population.
  
  
  METHODS
  The study cohort consisted of 238 chronic hepatitis C patients treated with interferon (IFN)-α-2b and ribavirin. Six single nucleotide polymorphisms were genotyped using the ABI TaqMan allelic discrimination assay. Biochemical indices were measured at baseline. Serum hepatitis C virus (HCV) RNA was detected at weeks 0, 4, 12 and 24 of therapy.
  
  
  RESULTS
  Only IL28B rs12980275 was associated with treatment response in the Chinese Han population. Patients carrying AG/GG genotypes had a reduced rapid viral response compared with patients carrying the AA genotype (additive model: adjusted OR = 0.43, 95%CI: 0.24-0.75). It took less time for patients with the AA genotype to achieve a viral load < 500 copies/mL (log-rank test, P = 0.004). In addition, the protective effect of genotype AA was independent of baseline viral load. HCV genotype, and baseline white blood cell count, α-fetoprotein and viral load might also help predict treatment response. The area under the receiver-operating characteristic curve was 0.726.
  
  
  CONCLUSIONS
  IL28B rs12980275 AA genotype is a strong predictor of positive response to IFN therapy in Chinese Han patients with hepatitis C.
authors: Yuan-Yuan Zhang, Yin Xu, Peng Huang, Rong-Bin Yu, Jing Su, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China.
authors: Yuan-Yuan
authors: YY
authors: Zhang
authors: Yuan-Yuan Zhang, Yin Xu, Peng Huang, Rong-Bin Yu, Jing Su, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China.
authors: Hong-Bo
authors: HB
authors: Chen
authors: Yuan-Yuan Zhang, Yin Xu, Peng Huang, Rong-Bin Yu, Jing Su, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China.
authors: Yin
authors: Y
authors: Xu
authors: Yuan-Yuan Zhang, Yin Xu, Peng Huang, Rong-Bin Yu, Jing Su, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China.
authors: Peng
authors: P
authors: Huang
authors: Yuan-Yuan Zhang, Yin Xu, Peng Huang, Rong-Bin Yu, Jing Su, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China.
authors: Jie
authors: J
authors: Wang
authors: Yuan-Yuan Zhang, Yin Xu, Peng Huang, Rong-Bin Yu, Jing Su, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China.
authors: Yun
authors: Y
authors: Zhang
authors: Yuan-Yuan Zhang, Yin Xu, Peng Huang, Rong-Bin Yu, Jing Su, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China.
authors: Rong-Bin
authors: RB
authors: Yu
authors: Yuan-Yuan Zhang, Yin Xu, Peng Huang, Rong-Bin Yu, Jing Su, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu Province, China.
authors: Jing
authors: J
authors: Su
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D019540:Area Under Curve; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D004359:Drug Therapy, Combination; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D007372:Interferons; D053710:Interleukin-10 Receptor beta Subunit / Q000235:genetics; D007378:Interleukins / Q000235:genetics; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D064547:Myxovirus Resistance Proteins / Q000235:genetics; D016017:Odds Ratio; D010597:Pharmacogenetics; D010641:Phenotype; D011092:Polyethylene Glycols / Q000627:therapeutic use*; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000097:blood; D012372:ROC Curve; D018121:Receptors, Cytokine / Q000235:genetics*; D017471:Receptors, Interferon; D011994:Recombinant Proteins / Q000627:therapeutic use; D012254:Ribavirin / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D019562:Viral Load; D000095022:Interferon Lambda
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007372:Interferons; D053710:Interleukin-10 Receptor beta Subunit; D007378:Interleukins; D064547:Myxovirus Resistance Proteins; D011092:Polyethylene Glycols; D012367:RNA, Viral; D018121:Receptors, Cytokine; D017471:Receptors, Interferon; D011994:Recombinant Proteins; D012254:Ribavirin; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C579640:IFNLR1 protein, human; C081846:IL10RB protein, human; C579071:MX1 protein, human; C417083:peginterferon alfa-2b
keywords: Chinese population; Hepatitis C virus; IL28B; Interferon; Rapid viral response