title: The emerging landscape of circular RNA ciRS-7 in cancer (Review).
abstract: Circular RNAs (circRNAs) are a novel class of non-coding RNA molecules ubiquitously present in the cytoplasm of eukaryotic cells. CircRNAs are generated from exons or introns via multiple mechanisms. A recently identified circRNA, ciRS-7, can regulate the activities of miRNAs, mRNAs, and RBP to exert specific biological effects. Also, ciRS-7 acts as a natural competing endogenous RNA, a.k.a. 'super sponge' of microRNA-7 (miR-7) that sequesters and competitively inhibits the activity of miR-7. This competition between ciRS-7 and miR-7 may have profound effects on oncogenesis. This review will summarize the origin and functions of ciRS-7 and discuss the relationship among ciRS-7, its target molecules and cancer.
authors: Cancer Research Institute, Central South University; Key Laboratory of Carcinogenesis, National Health and Family Planning Commission; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, P.R. China.
authors: Li
authors: L
authors: Peng
authors: Department of Clinical Pharmacology, Xiangya Hospital, Central South University; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P.R. China.
authors: Xiao Qing
authors: XQ
authors: Yuan
authors: Cancer Research Institute, Central South University; Key Laboratory of Carcinogenesis, National Health and Family Planning Commission; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, P.R. China.
authors: Guan Cheng
authors: GC
authors: Li
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D012313:RNA / Q000235:genetics*; D000079962:RNA, Circular; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D035683:MicroRNAs; D012313:RNA; D000079962:RNA, Circular; D012333:RNA, Messenger; C549242:MIRN7-1 microRNA, human