title: Preparation of acetylsalicylic acid-acylated chitosan as a novel polymeric drug for drug controlled release.
abstract: The acetylsalicylic acid-acylated chitosan (ASACTS) with high degree of substitution (DS) was successfully synthesized, and characterized with FTIR, (1)H NMR and elemental analysis methods. The optimum synthesis conditions were obtained which gave the highest DS (about 60%) for ASACTS. Its drug release experiments were carried out in simulated gastric and intestine fluids. The results show that the drugs in the form of acetylsalicylic acid (ASA) and salicylic acid (SA) were released in a controlled manner from ASACTS only in simulated gastric fluid. The release profile can be best fitted with logistic and Weibull model. The research results reveal that ASACTS can be a potential polymeric drug for the controlled release of ASA and SA in the targeted gastric environment.
authors: School of Chemistry and Chemical Engineering, Shenzhen University, 3688 Nanhai Ave., Shenzhen 518060, Guangdong Prov., P.R. China.
authors: Changkun
authors: C
authors: Liu
authors: School of Chemistry and Chemical Engineering, Shenzhen University, 3688 Nanhai Ave., Shenzhen 518060, Guangdong Prov., P.R. China. Electronic address: yebsd@sina.com.
authors: Yiguang
authors: Y
authors: Wu
authors: School of Chemistry and Chemical Engineering, Shenzhen University, 3688 Nanhai Ave., Shenzhen 518060, Guangdong Prov., P.R. China.
authors: Liyan
authors: L
authors: Zhao
authors: School of Chemistry and Chemical Engineering, Shenzhen University, 3688 Nanhai Ave., Shenzhen 518060, Guangdong Prov., P.R. China.
authors: Xinzheng
authors: X
authors: Huang
mesh_terms: D000107:Acetylation; D001241:Aspirin / Q000008:administration & dosage*; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D065546:Drug Liberation; D066244:Proton Magnetic Resonance Spectroscopy; D020156:Salicylic Acid / Q000008:administration & dosage; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D003692:Delayed-Action Preparations; D048271:Chitosan; D020156:Salicylic Acid; D001241:Aspirin
keywords: Acetylsalicylic acid; Chitosan; Controlled release