title: Ochronotic involvement of the aortic and mitral valves in a 72-year-old man.
abstract: Ochronosis, an autosomal recessive metabolic disorder, causes an excess of homogentisic acid that results in adverse pigmentation, calcification, and inflammation of cartilaginous and other tissues. Cardiovascular abnormalities are less frequently reported than are other manifestations. In rare cases, ochronosis can cause valvular heart disease. We report the case of a 72-year-old man with aortic stenosis and mitral insufficiency who was diagnosed with ochronosis while undergoing surgical aortic and mitral valve replacement. We discuss the history and surgical management of alkaptonuric ochronosis.
authors: Atakan
authors: A
authors: Atalay
authors: Ugur
authors: U
authors: Gocen
authors: Yuksel
authors: Y
authors: Basturk
authors: Erkan
authors: E
authors: Kozanoglu
authors: Hafize
authors: H
authors: Yaliniz
mesh_terms: D000474:Alkaptonuria; D001021:Aortic Valve; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D001706:Biopsy; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008943:Mitral Valve; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D009794:Ochronosis / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D011237:Predictive Value of Tests
keywords: Alkaptonuria/complications/diagnosis/pathology; aortic valve/pathology; calcinosis/radiography; heart diseases/diagnosis; heart valve prosthesis implantation; homogentisic acid/urine; ochronosis/diagnosis/pathology