title: [The lipid peroxidation processes in males with chronic mono trichomonal infection against the background of intake of triethanolammonium salt of 2-methyl phenoxiacetic acid].
abstract: The research center of problems of family health and human reproduction, Irkutsk, Russia The article presents the results of evaluation of processes of lipid peroxidation and anti-oxidant defense in males with chronic mono trichomonal infection against the background of intake of triethanolammonium salt of methyl phenoxiacetic acid, pharmaceutical of phytohormones class with anti-oxidant characteristics. The sampling for examination consisted of 61 males with chronic urogenital trichomoniasis. The blood plasma and hemolysate prepared from erythrocytes were used as material for biochemical analysis. The modern spectrophotometric, fluorometric and statistical method of analysis were applied. In examined patients the parameters characterizing significant disorders of metabolic homeostasis were analyzed. The condition of lipids peroxidation was judged by blood concentration of substrates with saturated double bounds, diene conjugates, tiobarbituric acid active products expressed in micromol per 1 liter. The intensity of processes of anti-oxidant defense was evaluated by content of concentrations of alpha-tokopherol and retinol, oxidated and reduced glutathione and by activity of super oxide dismutase too. The common anti-oxidant activity of blood was measured as indicator characterizing sum total of inhibitors of lipid peroxidation and determining its buffer capacity. The reduction of balance in the system pro-oxidant-anti-oxidant in direction to anti-oxidant components is marked in group of patients with chronic mono trichomonal infection after complex treatment including as add-on to common therapy triethanolammonium salt of 2-methyl phenoxiacetic acid. The effectiveness of complex therapy in many instances depends on degree of defense of structure and function of cellular membranes. Therefore, application of this pharmaceutical is appropriate because of decreasing of level of lipid peroxidation, increasing of anti-oxidant defense of organism and normalizing of particular parameters of spermatogenesis.
authors: L I
authors: LI
authors: Kolesnikov
authors: N A
authors: NA
authors: Kurashova
authors: M I
authors: MI
authors: Dolgikh
authors: N A
authors: NA
authors: Neronova
authors: E A
authors: EA
authors: Kirilenko
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D004983:Ethanolamines / Q000627:therapeutic use; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012426:Russia; D013482:Superoxide Dismutase / Q000097:blood; D014245:Trichomonas Infections / Q000097:blood / Q000188:drug therapy*
chemical_list: D000975:Antioxidants; D004983:Ethanolamines; D017382:Reactive Oxygen Species; C009546:triethanolamine; D013482:Superoxide Dismutase