title: Hold the salt: vasopressor role for BDNF.
abstract: In a recent publication in Neuron, Choe et al. (2015) demonstrate that brain-derived neurotrophic factor (BDNF) signaling mediates salt-induced blood pressure elevation by increasing the excitability of hypothalamic vasopressin-secreting neurons. These findings suggest complex roles for BDNF in adaptive cardiovascular responses to physiological challenges and in the pathogenesis of hypertension.
authors: Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
authors: Krisztina
authors: K
authors: Marosi
authors: Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: mark.mattson@nih.gov.
authors: Mark P
authors: MP
authors: Mattson
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D019208:Brain-Derived Neurotrophic Factor / Q000494:pharmacology*; D008297:Male; D017673:Sodium Chloride, Dietary / Q000009:adverse effects*; D027981:Symporters / Q000378:metabolism*; D014667:Vasopressins / Q000378:metabolism*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D017673:Sodium Chloride, Dietary; D027981:Symporters; D014667:Vasopressins