title: Minor Prenylated Flavonoids from the Twigs ofMacarangaadenanthaand Their Cytotoxic Activity.
abstract: Three new minor prenylated flavonoids, named macadenanthins A-C (1-3), together with three known ones (4-6), were isolated from the twigs ofMacaranga adenantha. Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR, UV and MS. The prenyl moieties in compounds1-3were further modified by cyclization and hydroxylation. The new compounds were tested for their cytotoxicity against four cancer cell lines (MCF-7, Hep G2, Hela and P388) and showed IC50values in the range of 13.76-22.27 μM.
authors: Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
authors: Da-Song
authors: DS
authors: Yang
authors: Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
authors: Shuang-Mei
authors: SM
authors: Wang
authors: Biology Institute of Shandong Academy of Sciences, Jinan, 250014 People's Republic of China.
authors: Wei-Bing
authors: WB
authors: Peng
authors: Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
authors: Yong-Ping
authors: YP
authors: Yang
authors: Biology Institute of Shandong Academy of Sciences, Jinan, 250014 People's Republic of China.
authors: Ke-Chun
authors: KC
authors: Liu
authors: Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
authors: Xiao-Li
authors: XL
authors: Li
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
authors: Wei-Lie
authors: WL
authors: Xiao
keywords: Cytotoxicity; Macadenanthins A–C; Macaranga adenantha; Prenylated Flavonoids