title: Gamma delta T-cell differentiation and effector function programming, TCR signal strength, when and how much?
abstract: γδ T-cells boast an impressive functional repertoire that can paint them as either champions or villains depending on the environmental and immunological cues. Understanding the function of the various effector γδ subsets necessitates tracing the developmental program of these subsets, including the point of lineage bifurcation from αβ T-cells. Here, we review the importance of signals from the T-cell receptor (TCR) in determining αβ versus γδ lineage fate, and further discuss how the molecular components of this pathway may influence the developmental programming of γδ T-cells functional subsets. Additionally, we discuss the role of temporal windows in restricting the development of IL-17 producing γδ T-cell subtypes, and explore whether fetal and adult hematopoietic progenitors maintain the same potential for giving rise to this important subset.
authors: Department of Immunology, University of Toronto, and Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
authors: Payam
authors: P
authors: Zarin
authors: Department of Immunology, University of Toronto, and Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
authors: Edward L Y
authors: EL
authors: Chen
authors: Department of Immunology, University of Toronto, and Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
authors: Tracy S H
authors: TS
authors: In
authors: Department of Immunology, University of Toronto, and Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada.
authors: Michele K
authors: MK
authors: Anderson
authors: Department of Immunology, University of Toronto, and Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada. Electronic address: jczp@sri.utoronto.ca.
authors: Juan Carlos
authors: JC
authors: Zúñiga-Pflücker
mesh_terms: D002454:Cell Differentiation; D019070:Cell Lineage / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: Gamma delta T cells; Lineage commitment; T cell development; T cell receptor