title: When one mutation is all it takes.
abstract: In a recent issue of Nature Genetics, Andersson and colleagues report that MLL fusion alone may be sufficient to spawn an aggressive leukemia in infants. Some other pediatric cancers may share a similar, single, "big-hit" origin, possibly reflecting a critical developmental window of stem cell vulnerability.
authors: Centre for Evolution and Cancer, The Institute of Cancer Research, London, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK. Electronic address: mel.greaves@icr.ac.uk.
authors: Mel
authors: M
authors: Greaves
mesh_terms: D006801:Humans; D009154:Mutation; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
chemical_list: D051788:Myeloid-Lymphoid Leukemia Protein