title: Thymoquinone protects end organs from abdominal aorta ischemia/reperfusion injury in a rat model.
abstract: BACKGROUND
  Previous studies have demonstrated that thymoquinone has protective effects against ischemia reperfusion injury to various organs like lungs, kidneys and liver in different experimental models.
  
  
  OBJECTIVE
  We aimed to determine whether thymoquinone has favorable effects on lung, renal, heart tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury.
  
  
  METHODS
  Thirty rats were divided into three groups as sham (n=10), control (n=10) and thymoquinone (TQ) treatment group (n=10). Control and TQ-treatment groups underwent abdominal aorta ischemia for 45 minutes followed by a 120-min period of reperfusion. In the TQ-treatment group, thymoquinone was given 5 minutes. before reperfusion at a dose of 20 mg/kg via an intraperitoneal route. Total antioxidant capacity, total oxidative status (TOS), and oxidative stress index (OSI) in blood serum were measured and lung, kidney, and heart tissue histopathology were evaluated with light microscopy.
  
  
  RESULTS
  Total oxidative status and oxidative stress index activity in blood samples were statistically higher in the control group compared to the sham and TQ-treatment groups (P<0.001 for TOS and OSI). Control group injury scores were statistically higher compared to sham and TQ-treatment groups (P<0.001 for all comparisons).
  
  
  CONCLUSIONS
  Thymoquinone administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta ischemia-reperfusion rat model.
authors: Department of Cardiovascular Surgery, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
authors: Mehmet Salih
authors: MS
authors: Aydin
authors: Department of Cardiovascular Surgery, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
authors: Aydemir
authors: A
authors: Kocarslan
authors: Department of Pathology, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
authors: Sezen
authors: S
authors: Kocarslan
authors: Department of Thoracic Surgery, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
authors: Ahmet
authors: A
authors: Kucuk
authors: Department of Thoracic Surgery, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
authors: İrfan
authors: İ
authors: Eser
authors: Department of Biochemistry, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
authors: Hatice
authors: H
authors: Sezen
authors: Department of Anesthesiology and Reanimation, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
authors: Evren
authors: E
authors: Buyukfirat
authors: Department of Cardiovascular Surgery, Faculty of Medicine, Harran Univercity, Sanliurfa, Turkey.
authors: Abdussemet
authors: A
authors: Hazar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001012:Aorta, Abdominal / Q000187:drug effects* / Q000473:pathology; D016227:Benzoquinones / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects; D007511:Ischemia / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D016227:Benzoquinones; D016877:Oxidants; D020011:Protective Agents; C003466:thymoquinone