title: A comprehensive review of plants and their active constituents with wound healing activity in traditional Iranian medicine.
abstract: BACKGROUND
  Wound healing is a complex cascade of events with various cellular and biochemical processes that result in reconstruction and regeneration of damaged tissue. The objective of the current study was to scientifically evaluate the medicinal plants said to produce wound healing activity in traditional Iranian medicine (TIM).
  
  
  METHODS
  Electronic databases were searched for the names of medicinal plants claimed in TIM literature for having wound healing activity. Articles were evaluated to obtain any in vitro, animal, or clinical evidence of their efficacy and possible mechanisms involved in would healing.
  
  
  RESULTS
  Mechanisms of action for some of these plants, including Tamarix spp., Rosa spp., Piper betle, Plantago major, Oxalis spp., Olea europaea, Malva spp., Linum usitatissimum, and Tamarindus indica, have not been yet clarified. In contrast, some herbs such as Vitis vinifera, Quercus spp., Punica granatum, Pinus spp., Polygonum spp., Lilium spp., Gentiana lutea, Arnebia euchroma, Aloe spp., and Caesalpinia spp. have various biological and pharmacological mechanisms that have been verified for wound healing activity.
  
  
  CONCLUSIONS
  Overall, TIM resources have introduced various medicinal plants for wounds with confirmed effectiveness according to current pharmacological studies. These herbal remedies could be considered as future drugs for healing of wounds. Further pharmacological and clinical investigations are recommended for exploring safety, exact mechanisms, and efficacy of these herbal remedies. ﻿﻿﻿.
authors: Kermanshah University of Medical Sciences, Kermanshah, Iran; and Department of Pharmacy in Traditional Medicine, Faculty of Traditional Medicine and Persian Medicine, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mohammad
authors: M
authors: Hosein Farzaei
authors: Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors: Zahra
authors: Z
authors: Abbasabadi
authors: Department of Pharmacy in Traditional Medicine, Faculty of Traditional Medicine and Persian Medicine, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mohammad
authors: M
authors: Reza Shams-Ardekani
authors: Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mohammad
authors: M
authors: Abdollahi
authors: Department of Pharmacy in Traditional Medicine, Faculty of Traditional Medicine and Persian Medicine, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Roja
authors: R
authors: Rahimi