title: Betatrophin levels are increased in women with gestational diabetes mellitus compared to healthy pregnant controls.
abstract: OBJECTIVE
  Betatrophin has recently been introduced as a novel adipokine/hepatokine, which promotes pancreatic β cell proliferation and improves glucose tolerance in several mouse models of insulin resistance. However, regulation of betatrophin in gestational diabetes mellitus (GDM), as well as its association with markers of obesity, such as glucose and lipid metabolism, inflammation, and renal function, have not been elucidated.
  
  
  METHODS
  Circulating betatrophin was quantified in 74 women with GDM and 74 healthy and gestational age-matched controls by ELISA. In a subset of the study population comprising of 85 patients (41 previous controls, 44 previous women with GDM), postpartum betatrophin levels were measured in a follow-up study.
  
  
  RESULTS
  Median (interquartile range) serum betatrophin levels were higher in women with GDM (1.79 (0.53) μg/l) as compared to non-diabetic pregnant controls (1.58 (0.44) μg/l) (P=0.002). In multivariate analysis, GDM status was an independent and positive predictor of circulating betatrophin (P=0.001). Furthermore, betatrophin levels were significantly higher during gestation (1.70 (0.53) μg/l) as compared to postpartum levels (1.55 (0.66) μg/l) (P=0.028). Moreover, postpartum irisin remained a positive and independent predictor of postpartum betatrophin concentrations.
  
  
  CONCLUSIONS
  Women with GDM have significantly higher betatrophin levels as compared to healthy pregnant controls and GDM status positively predicts circulating betatrophin. Furthermore, postpartum levels are significantly lower as compared to betatrophin concentrations during pregnancy. Moreover, irisin is a significant predictor of postpartum betatrophin levels.
authors: Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany Thomas.ebert@medizin.uni-leipzig.de.
authors: Thomas
authors: T
authors: Ebert
authors: Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany.
authors: Susan
authors: S
authors: Kralisch
authors: Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany.
authors: Ulrike
authors: U
authors: Wurst
authors: Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany.
authors: Ulrike
authors: U
authors: Lössner
authors: Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany.
authors: Jürgen
authors: J
authors: Kratzsch
authors: Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany.
authors: Matthias
authors: M
authors: Blüher
authors: Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany.
authors: Michael
authors: M
authors: Stumvoll
authors: Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany.
authors: Anke
authors: A
authors: Tönjes
authors: Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany Department of Endocrinology and NephrologyUniversity of Leipzig, Liebigstraße 20, 04103 Leipzig, GermanyLeipzig University Medical CenterIFB AdiposityDiseases, Liebigstraße 20, 04103 Leipzig, GermanyInstitute of Laboratory MedicineUniversity of Leipzig, Leipzig, Germany.
authors: Mathias
authors: M
authors: Fasshauer
mesh_terms: D000328:Adult; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D001774:Blood Chemical Analysis; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005353:Fibronectins / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D036361:Peptide Hormones / Q000097:blood*; D011247:Pregnancy
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; C577593:FNDC5 protein, human; D005353:Fibronectins; D036361:Peptide Hormones