title: Bucillamine-induced membranous nephropathy with crescent formation in a patient with rheumatoid arthritis: case report and literature review.
abstract: Bucillamine is a disease-modifying antirheumatic drug that is structurally similar to D-penicillamine. The major renal side effect of bucillamine and D-penicillamine is proteinuria caused by membranous nephropathy (MN). In addition to MN, combined crescent formation has been occasionally reported in D-penicillamine-induced MN, while crescent formation has been rarely reported in bucillamine-treated cases. Here, we describe a 76-year-old female who presented with nephrotic syndrome and rapidly progressive glomerulonephritis. She was receiving bucillamine as initial treatment for recently diagnosed rheumatoid arthritis, and renal biopsy showed MN with crescent formation. To the best of our knowledge, this is the first report of bucillamine-induced MN with crescent formation in the English literature.
authors: Department of Nephrology, Yokohama Rosai Hospital, Yokohama, Japan.
authors: Shun
authors: S
authors: Manabe
authors: Department of Nephrology, Yokohama Rosai Hospital, Yokohama, Japan.
authors: Mayuko
authors: M
authors: Banno
authors: Department of Nephrology, Yokohama Rosai Hospital, Yokohama, Japan.
authors: Marie
authors: M
authors: Nakano
authors: Department of Nephrology, Yokohama Rosai Hospital, Yokohama, Japan.
authors: Teruhiro
authors: T
authors: Fujii
authors: Department of Rheumatology, Yokohama Rosai Hospital, Yokohama, Japan.
authors: Michio
authors: M
authors: Fujiwara
authors: Department of Rheumatology, Yokohama Rosai Hospital, Yokohama, Japan.
authors: Yasuhiko
authors: Y
authors: Kita
authors: Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan.
authors: Kosaku
authors: K
authors: Nitta
authors: Department of Nephrology, Yokohama Rosai Hospital, Yokohama, Japan.
authors: Michiyasu
authors: M
authors: Hatano
keywords: Bucillamine; Crescent formation; Membranous nephropathy; Nephrotic syndrome; Rapidly progressive glomerulonephritis; Rheumatoid arthritis