title: Quantification of in vivo ³¹P NMR brain spectra using LCModel.
abstract: Quantification of (31)P NMR spectra is commonly performed using line-fitting techniques with prior knowledge. Currently available time- and frequency-domain analysis software includes AMARES (in jMRUI) and CFIT respectively. Another popular frequency-domain approach is LCModel, which has been successfully used to fit both (1)H and (13)C in vivo NMR spectra. To the best of our knowledge LCModel has not been used to fit (31)P spectra. This study demonstrates the feasibility of using LCModel to quantify in vivo (31)P MR spectra, provided that adequate prior knowledge and LCModel control parameters are used. Both single-voxel and MRSI data are presented, and similar results are obtained with LCModel and with AMARES. This provides a new method for automated, operator-independent analysis of (31)P NMR spectra.
authors: Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
authors: Dinesh Kumar
authors: DK
authors: Deelchand
authors: INSERM UMR S975, Brain and Spine Institute, Hospital La Salpêtrière, Paris, France.
authors: Tra-My
authors: TM
authors: Nguyen
authors: Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
authors: Xiao-Hong
authors: XH
authors: Zhu
authors: INSERM UMR S975, Brain and Spine Institute, Hospital La Salpêtrière, Paris, France.|University Pierre and Marie Curie, Paris, France.|AP-HP, Department of Genetics, Hospital La Salpêtrière, Paris, France.
authors: Fanny
authors: F
authors: Mochel
authors: Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
authors: Pierre-Gilles
authors: PG
authors: Henry
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003198:Computer Simulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D051379:Mice; D008954:Models, Biological; D008956:Models, Chemical; D017553:Phosphorus Compounds / Q000378:metabolism*; D010759:Phosphorus Isotopes / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D017553:Phosphorus Compounds; D010759:Phosphorus Isotopes
keywords: 31P; AMARES; LCModel; MRSI; animal; brain; human; jMRUI