title: Primary rhabdomyosarcoma of the pineal gland.
abstract: OBJECTIVE
  To report a case of primary rhabdomyosarcoma (RMS) of the pineal gland in an adult, as well as review the literature on this rare entity.
  
  
  METHODS
  The case is compared with previous reports of similar entities, with emphasis on this patient's characteristics and clinical presentation, investigations, and management.
  
  
  RESULTS
  Diagnosis of primary RMS of the pineal gland was based on the presence of strap cells and multinucleated myotube-like structures, as well as tumor cell expression of skeletal muscle markers consistent with myogenic differentiation. Multimodality treatment was initiated based on pediatric protocols. Unfortunately, the disease progressed on treatment, and the patient survived only 5 months from diagnosis.
  
  
  CONCLUSIONS
  Pineal RMS is a rare disease with poor prognosis. Optimal management is unknown but likely to involve aggressive multimodality therapy.
authors: From the Departments of Surgery, steven.lau@utsouthwestern.edu.
authors: Steven K M
authors: SK
authors: Lau
authors: Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX; and Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston.
authors: Matthew D
authors: MD
authors: Cykowski
authors: From the Departments of Surgery.
authors: Shiv
authors: S
authors: Desai
authors: Pathology, and.
authors: Ying
authors: Y
authors: Cao
authors: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston.
authors: Gregory N
authors: GN
authors: Fuller
authors: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston.
authors: Janet
authors: J
authors: Bruner
authors: Hematology & Oncology, Straub Clinic & Hospital, Honolulu, HI;
authors: Ian
authors: I
authors: Okazaki
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010870:Pineal Gland / Q000378:metabolism / Q000473:pathology*; D012208:Rhabdomyosarcoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
keywords: Primary intracranial rhabdomyosarcoma; Primary pineal rhabdomyosarcoma; adult rhabdomyosarcoma