title: Cost-effectiveness of non-surgical peri-implantitis treatments.
abstract: OBJECTIVE
  The purpose of the present study was to assess the cost-effectiveness of various alternatives of non-surgical peri-implantitis treatment.
  
  
  METHODS
  A decision analytical model was constructed and populated with parameter estimates from recent literature for reduction in pocket probing depth (PPD) in response to eight different treatment alternatives. A micro-costing approach combined with an online expert survey was applied to simulate a decision-making scenario taking place in Germany. The treatment alternatives providing the most advantageous cost/outcome combinations were identified according to the net benefit criterion. Uncertainties regarding model input parameters were incorporated via simple and probabilistic sensitivity analysis based on Monte Carlo simulation.
  
  
  RESULTS
  In the base case scenario, debridement alone, Air-Flow, debridement combined with PerioChip, and debridement combined with local antibiotics were identified as treatment strategies with comparably better value for money than Er:YAG laser monotherapy, Vector System, debridement combined with CHX, and photodynamic therapy. Sensitivity analysis revealed considerable decision uncertainty corresponding to limited evidence about different treatment alternatives for peri-implantitis treatment.
  
  
  CONCLUSIONS
  Derivation of robust treatment recommendations for peri-implantitis requires more comprehensive and patient-centred evidence on peri-implantitis treatments.
authors: Translational Health Economics Group (THE Group), Department of Conservative Dentistry, Heidelberg University, Heidelberg, Germany.|Max Planck Institute for Social Law and Social Policy, Munich Center for the Economics of Aging, Munich, Germany.
authors: Stefan
authors: S
authors: Listl
authors: Translational Health Economics Group (THE Group), Department of Conservative Dentistry, Heidelberg University, Heidelberg, Germany.
authors: Nadine
authors: N
authors: Frühauf
authors: Translational Health Economics Group (THE Group), Department of Conservative Dentistry, Heidelberg University, Heidelberg, Germany.
authors: Bettina
authors: B
authors: Dannewitz
authors: Translational Health Economics Group (THE Group), Department of Conservative Dentistry, Heidelberg University, Heidelberg, Germany.
authors: Christiane
authors: C
authors: Weis
authors: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors: Yu-Kang
authors: YK
authors: Tu
authors: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors: Huei-Ju
authors: HJ
authors: Chang
authors: Department of Periodontology, Faculty of Dentistry, University of Münster, Münster, Germany.
authors: Clovis M
authors: CM
authors: Faggion
mesh_terms: D000900:Anti-Bacterial Agents / Q000191:economics / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000191:economics / Q000627:therapeutic use; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000191:economics / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000191:economics; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D003775:Dental Polishing / Q000191:economics / Q000295:instrumentation; D005382:Financing, Personal / Q000191:economics; D017048:Health Care Costs; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use; D009010:Monte Carlo Method; D057873:Peri-Implantitis / Q000191:economics* / Q000628:therapy; D057747:Periodontal Debridement / Q000191:economics* / Q000295:instrumentation; D010514:Periodontal Pocket / Q000191:economics / Q000628:therapy; D010778:Photochemotherapy / Q000191:economics; D011336:Probability; D012680:Sensitivity and Specificity; D007507:Therapeutic Irrigation / Q000191:economics / Q000295:instrumentation; D016896:Treatment Outcome; D035501:Uncertainty
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; C010882:chlorhexidine gluconate; D002710:Chlorhexidine
keywords: cost-effectiveness analysis; micro-costing; online expert survey; peri-implantitis