title: Eosinophilic cardiac disease: Molecular, clinical and imaging aspects.
abstract: Eosinophilia may be responsible for cardiac injuries of widely varying severity, from acute myocarditis to endomyocardial fibrosis. In this review, we present both the molecular mechanisms that are responsible for these lesions and their clinical and paraclinical aspects. Numerous aetiologies can lead to severe eosinophilia, but these are mainly represented by hypersensitivity reactions, rheumatological diseases and hypereosinophilic syndrome. Because cardiac involvement may be extremely severe, echocardiography should be always performed in the context of eosinophilia and appropriate therapeutics should be started rapidly in order to limit the progression of the disease.
authors: Pediatric Cardiology Unit, Hôpital Haut Lévèque, Bordeaux University Hospital, Bordeaux, France. Electronic address: peseguela@yahoo.fr.
authors: Pierre-Emmanuel
authors: PE
authors: Séguéla
authors: Pediatric Cardiology Unit, Hôpital Haut Lévèque, Bordeaux University Hospital, Bordeaux, France.
authors: Xavier
authors: X
authors: Iriart
authors: Pediatric Cardiology Unit, Hôpital des Enfants, Toulouse University Hospital, Toulouse, France.
authors: Philippe
authors: P
authors: Acar
authors: Thoracic and Cardiovascular Imaging Unit, Hôpital Haut Lévèque, Bordeaux University Hospital, Bordeaux, France.
authors: Michel
authors: M
authors: Montaudon
authors: Cardiology Unit, Hôpital Haut Lévèque, Bordeaux University Hospital, Bordeaux, France.
authors: Raymond
authors: R
authors: Roudaut
authors: Pediatric Cardiology Unit, Hôpital Haut Lévèque, Bordeaux University Hospital, Bordeaux, France.
authors: Jean-Benoit
authors: JB
authors: Thambo
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D003952:Diagnostic Imaging / Q000379:methods; D004802:Eosinophilia / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D004804:Eosinophils / Q000378:metabolism / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D009336:Necrosis; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers
keywords: Cardiomyopathie restrictive; DRESS syndrome; Endomyocardial fibrosis; Eosinophilia; Eosinophilic myocarditis; Fibrose endomyocardique; Hyperéosinophilie; Myocardite à éosinophiles; Restrictive cardiomyopathy; Syndrome DRESS