title: Association of programmed cell death 1 and programmed cell death 1 ligand gene polymorphisms with delayed graft function and acute rejection in kidney allograft recipients.
abstract: BACKGROUND
  The genetic variations of co-stimulatory molecules can affect the extent of T cell activity during T-cell mediated immunity, especially in transplant patients. This study aimed to investigate the association of programmed cell death 1 (PDCD1) and programmed cell death 1 ligand 1 (PDCD1LG1) gene polymorphisms with clinical outcome of kidney transplantation.
  
  
  METHODS
  A total of 122 patients with a kidney transplant were included in this retrospective study. Patients were classified into two groups of biopsy-proven acute allograft rejection (AAR) and stable graft function (SGF) during the 5-year follow-up period. Four single nucleotide polymorphisms in PDCD1 and PDCD1LG1 were determined in the groups of patients as well as in 208 healthy control individuals.
  
  
  RESULTS
  The frequencies of PD-1.3 (+7146 G>A), PD-1.9 (+7625 C>T), PD-L1 (8923 A>C), and PD-L1 (+6777 C>G) genotypes and alleles were not significantly different between the AAR and SGF groups. In comparison with healthy controls, PD-1.9 (+7625 C>T) genotype and T allele were significantly more frequent in all of the patients and in those with SGF. Overall, 27 of 122 kidney allograft recipients experienced delayed graft function, and a higher frequency of PD-1.9 (+7625 C>T) genotype and T allele was observed in this group versus those without delayed graft function. Similarly, a significant high frequency of this genotype was found among the AAR subgroup of patients with delayed graft function.
  
  
  CONCLUSIONS
  Our results indicate that potentially functional genetic variation in PDCD1 can influence the outcome of kidney transplantation.
authors: Leila
authors: L
authors: Zolfaghari
authors: Ghasem
authors: G
authors: Solgi
authors: Mohsen
authors: M
authors: Nafar
authors: Pedram
authors: P
authors: Ahmadpour
authors: Mahboob
authors: M
authors: Lassanpezeshki
authors: Mohammad
authors: M
authors: Ali Amirzargar
authors: Mohammad Hossein Hossein
authors: MH
authors: Sharbafi
authors: Fatemeh
authors: F
authors: Pourrezagholi
authors: Fariba
authors: F
authors: Samadian
authors: Mahmoud
authors: M
authors: Parvin
authors: Effat
authors: E
authors: Razeghi
authors: Mohammad Hossein
authors: MH
authors: Nicknam
authors: Robabe
authors: R
authors: Ghodssi-Ghasemabadi
authors: Molecular Immunology Research Center and Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran. amirzara@sina.tums.ac.ir.
authors: Aliakbar
authors: A
authors: Amirzargar
mesh_terms: D000328:Adult; D000483:Alleles; D064591:Allografts / Q000276:immunology*; D060890:B7-H1 Antigen / Q000235:genetics*; D051799:Delayed Graft Function / Q000235:genetics* / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D014644:Genetic Variation / Q000276:immunology; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D061026:Programmed Cell Death 1 Receptor / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D060890:B7-H1 Antigen; C423236:CD274 protein, human; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor