title: Effects of long-term consumption of standard diets including glucose-lysine model glycated compounds on the antioxidant status of adult rats.
abstract: Our purpose was to evaluate the uptake of antioxidant capacity (AC) in rats fed long-term a diet containing commonly consumed Maillard reaction products (MRPs) from the glucose-lysine system. The effects on the oxidative status of liver, biceps brachii muscle and serum were also tested. The presence of model MRPs in the diet, especially melanoidins, led to a significantly higher intake (24.0μmolTrolox/day), faecal excretion (0.604μmolTrolox/day), and uptake (23.4μmolTrolox/day) of AC, although the uptake rate remained stable compared to the control group (97.5%). Consumption of the assayed MRPs did not affect the hepatic antioxidant defence while some positive modifications, like an increase in glutathione peroxidase, were detected in muscle (29%) and serum (400%). This pointed to an improved antioxidant capacity. Despite the interesting findings for these specific MRPs, attention must be paid to the overall consumption of MRPs from different sources in a conventional diet, due to their implications in the development/advance of many disorders.
authors: Departamento de Fisiología y Bioquímica de la Nutrición Animal (INAN), Estación Experimental del Zaidín (CSIC), Armilla, Granada, Spain.
authors: Silvia
authors: S
authors: Pastoriza
authors: Departamento de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Granada, Granada, Spain.
authors: José Ángel
authors: JÁ
authors: Rufián-Henares
authors: Departamento de Fisiología y Bioquímica de la Nutrición Animal (INAN), Estación Experimental del Zaidín (CSIC), Armilla, Granada, Spain. Electronic address: cdelgado@eez.csic.es.
authors: Cristina
authors: C
authors: Delgado-Andrade
mesh_terms: D000818:Animals; D000975:Antioxidants; D004032:Diet; D005947:Glucose / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008239:Lysine / Q000378:metabolism*; D015416:Maillard Reaction; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats
chemical_list: D000975:Antioxidants; D005979:Glutathione Peroxidase; D005947:Glucose; D008239:Lysine
keywords: CAT; GPx; GSH; Global antioxidant response; Model Maillard compounds; SOD