title: Novel zinc alginate hydrogels prepared by internal setting method with intrinsic antibacterial activity.
abstract: In this paper, a controlled gelation of alginate was performed for the first time using ZnCO3 and GDL. Uniform and transparent gels were obtained and investigated as potential wound dressings. Homogeneity, water content, swelling capability, water evaporation rate, stability in normal saline solution, mechanical properties and antibacterial activity were assessed as a function of zinc concentration. Gelation rate increased at increasing zinc content, while a decrease in water uptake and an improvement of stability were found. Release of zinc in physiological environments showed that concentration of zinc released in solution lies below the cytotoxicity level. Hydrogels showed antimicrobial activity against Escherichia coli. The hydrogel with highest zinc content was stabilized with calcium by immersion in a calcium chloride solution. The resulting hydrogel preserved homogeneity and antibacterial activity. Furthermore, it showed even an improvement of stability and mechanical properties, which makes it suitable as long-lasting wound dressing.
authors: Institute for Polymers, Composite and Biomaterials, CNR, via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy. Electronic address: mariacristina.straccia@ictp.cnr.it.
authors: Maria Cristina
authors: MC
authors: Straccia
authors: Institute for Polymers, Composite and Biomaterials, CNR, via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy. Electronic address: giovanna.gomez@ictp.cnr.it.
authors: Giovanna Gomez
authors: GG
authors: d'Ayala
authors: Institute of Biomolecular Chemistry, CNR, via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy. Electronic address: iromano@icb.cnr.it.
authors: Ida
authors: I
authors: Romano
authors: Institute for Polymers, Composite and Biomaterials, CNR, via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy. Electronic address: paola.laurienzo@ictp.cnr.it.
authors: Paola
authors: P
authors: Laurienzo
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D058105:Polymerization; D015032:Zinc / Q000737:chemistry*
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D020100:Hydrogels; D015032:Zinc
keywords: Antibacterial activity; Internal gelation; Wound dressing; Zinc alginate