title: Association between regional white and gray matter volume and ambiguity tolerance: Evidence from voxel-based morphometry.
abstract: The concept of tolerance of ambiguity (AT) is defined as the way in which an individual tends to perceive and deal with confusing, vague, and unclear situations. AT is generally considered as an important personality trait, but the neural mechanisms underlying individual differences in AT have never been investigated. Using voxel-based morphometry and MSTAT-II scale, we investigated the correlations between AT and regional white matter volume (rWMV) and regional gray matter volume (rGMV) in 351 young healthy subjects. We found AT to be positively correlated with rGMV in the dorsolateral prefrontal cortex (DLPFC), and negatively correlated with rGMV in the precuneus. These results indicate that increased rGMV in the left DLPFC may lead to characteristics of ambiguous stimuli consideration from multiple contexts and risk taking. Decreased rGMV in the left precuneus may be associated with a high tolerance for ambiguity, which attributes uncertainty to self-related factors.
authors: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.|Department of Psychology, Southwest University, Chongqing, China.
authors: Dandan
authors: D
authors: Tong
authors: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.|Department of Psychology, Southwest University, Chongqing, China.
authors: Wenjing
authors: W
authors: Yang
authors: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.|Department of Psychology, Southwest University, Chongqing, China.
authors: Qinglin
authors: Q
authors: Zhang
authors: Mental Health Department of Jining Medical University, Jining, China.
authors: Wenfu
authors: W
authors: Li
authors: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.|Department of Psychology, Southwest University, Chongqing, China.
authors: Dongtao
authors: D
authors: Wei
authors: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.|Department of Psychology, Southwest University, Chongqing, China.
authors: Xianwei
authors: X
authors: Che
authors: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.|Department of Psychology, Southwest University, Chongqing, China.|Department of Psychology, Xinxiang Medical University, Xinxiang, China.
authors: Meng
authors: M
authors: Zhang
authors: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.|Department of Psychology, Southwest University, Chongqing, China.
authors: Glenn
authors: G
authors: Hitchman
authors: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.|Department of Psychology, Southwest University, Chongqing, China.
authors: Jiang
authors: J
authors: Qiu
authors: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.|Department of Psychology, Southwest University, Chongqing, China.
authors: Yijun
authors: Y
authors: Liu
authors: Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.|Department of Psychology, Southwest University, Chongqing, China.
authors: Guikang
authors: G
authors: Cao
mesh_terms: D000293:Adolescent; D001921:Brain / Q000033:anatomy & histology*; D005260:Female; D066128:Gray Matter / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007206:Individuality; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D009929:Organ Size; D035501:Uncertainty; D066127:White Matter / Q000033:anatomy & histology*; D055815:Young Adult
keywords: DLPFC; Precuneus; Tolerance of ambiguity; Voxel-based morphometry