title: The effect of maternal polycystic ovary morphology on first-trimester maternal serum biochemical markers of aneuploidy and fetal nuchal translucency thickness.
abstract: OBJECTIVE
  To evaluate the effect of maternal polycystic ovary (PCO) morphology on maternal serum free beta-human chorionic gonadotropin (β-hCG), pregnancy associated plasma protein A (PAPP-A), and nuchal translucency (NT) thickness in the first-trimester.
  
  
  METHODS
  A total of 92 pregnant women in the first-trimester were included in the study. Of them, 57 had PCO morphology, and 35 women constituted the control group, with apparently normal ovaries. Maternal serum free β-hCG, PAPP-A, and NT thickness were measured and compared in all patients.
  
  
  RESULTS
  The multiples of median (MoM) levels of serum free β-hCG were significantly higher in the PCO morphology group compared to the normal ovary group (p = 0.024). However, the MoM levels of PAPP-A were similar in both groups (p = 0.947). No difference was found between the groups in terms of fasting glucose levels and NT measurements (p = 0.976 and 0.565, respectively).
  
  
  CONCLUSIONS
  In pregnancies with maternal PCO morphology, the presence of higher maternal serum free β-hCG levels may require correction in the calculation of risks related to first-trimester screening for chromosomal abnormalities. Larger studies are needed to confirm our preliminary data.
authors: S
authors: S
authors: Hacivelioglu
authors: A
authors: A
authors: Uysal
authors: A N Cakir
authors: AN
authors: Gungor
authors: M
authors: M
authors: Gencer
authors: D U
authors: DU
authors: Cakir
authors: E
authors: E
authors: Cosar
mesh_terms: D000328:Adult; D000782:Aneuploidy; D015415:Biomarkers / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005260:Female; D006801:Humans; D048208:Nuchal Translucency Measurement / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000000981:diagnostic imaging / Q000378:metabolism; D011261:Pregnancy Trimester, First / Q000097:blood; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D011296:Prenatal Diagnosis
chemical_list: D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A