title: CD45 antigen negativity in T-lineage ALL correlates with PTPRC mutation and sensitivity to a selective JAK inhibitor.
authors: Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.
authors: Sara
authors: S
authors: Raponi
authors: Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.
authors: Valentina
authors: V
authors: Gianfelici
authors: Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.
authors: Sabina
authors: S
authors: Chiaretti
authors: Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.
authors: Nadia
authors: N
authors: Peragine
authors: Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.
authors: Fulvia
authors: F
authors: Brugnoletti
authors: Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.
authors: Maria S
authors: MS
authors: De Propris
authors: Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.
authors: Marilisa
authors: M
authors: Marinelli
authors: Centre for Human Genetics, KU Leuven, Leuven, Belgium.
authors: Gert
authors: G
authors: Hulselmans
authors: Centre for Human Genetics, KU Leuven, Leuven, Belgium.
authors: Stein
authors: S
authors: Aerts
authors: Centre for Human Genetics, KU Leuven, Leuven, Belgium.|Centre for the Biology of Disease, VIB, Leuven, Belgium.
authors: Ellen
authors: E
authors: Geerdens
authors: Centre for Human Genetics, KU Leuven, Leuven, Belgium.|Centre for the Biology of Disease, VIB, Leuven, Belgium.
authors: Jan
authors: J
authors: Cools
authors: Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy.
authors: Robin
authors: R
authors: Foà
authors: Haematology, Department of Cellular Biotechnologies and Haematology, Sapienza University, Rome, Italy. guarini@bce.uniroma1.it.
authors: Anna
authors: A
authors: Guarini
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D053613:Janus Kinase 1 / Q000037:antagonists & inhibitors*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy* / Q000235:genetics; D017493:Leukocyte Common Antigens / Q000172:deficiency* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009570:Nitriles; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011720:Pyrazoles / Q000627:therapeutic use; D011743:Pyrimidines
chemical_list: D000970:Antineoplastic Agents; D009570:Nitriles; D011720:Pyrazoles; D011743:Pyrimidines; C540383:ruxolitinib; C507904:JAK1 protein, human; D053613:Janus Kinase 1; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human
keywords: CD45 antigen; JAK1 mutation; PTPRC mutation; T-lineage acute lymphoblastic leukaemia; target therapy