title: Establishment of a total liquid ventilation system using saline-based oxygen micro/nano-bubble dispersions in rats.
abstract: Micro/nano-bubbles are practical nanomaterials designed to increase the gas content in liquids. We attempted to use oxygen micro/nano-bubble dispersions as an oxygen-rich liquid as a means for total liquid ventilation. To determine the oxygen content in the bubble dispersion, a new method based on a spectrophotometric change between oxy- and deoxy-hemoglobin was established. The oxygen micro/nano-bubble dispersion was supplied to an experimental total ventilation liquid in anesthetic rats. Though the amount of dissolving oxygen was as low as 6 mg/L in physiological saline, the oxygen content in the oxygen micro/nano-bubble dispersion was increased to 45 mg/L. The positive correlation between the oxygen content and the life-saving time under liquid ventilation clearly indicates that the life-saving time is prolonged by increasing the oxygen content in the oxygen micro/nano-bubble dispersion. This is the first report indicating that the oxygen micro/nano-bubbles containing a sufficient amount of oxygen are useful in producing oxygen-rich liquid for the process of liquid ventilation.
authors: Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University (TWIns), 2-2 Wakamatsu-Cho, Shinjuku-Ku, Tokyo, 162-8480, Japan.
authors: Kenta
authors: K
authors: Kakiuchi
authors: Kenichi
authors: K
authors: Matsuda
authors: Norikazu
authors: N
authors: Harii
authors: Keitaro
authors: K
authors: Sou
authors: Junko
authors: J
authors: Aoki
authors: Shinji
authors: S
authors: Takeoka
mesh_terms: D000818:Animals; D004867:Equipment Design; D021061:Liquid Ventilation / Q000295:instrumentation*; D008297:Male; D045423:Microbubbles; D010100:Oxygen; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride
chemical_list: D012965:Sodium Chloride; D010100:Oxygen