title: Intra-abdominal pressure correlates with extracellular water content.
abstract: BACKGROUND
  Secondary increase in intra-abdominal pressure (IAP) may result from extra-abdominal pathology, such as massive fluid resuscitation, capillary leak or sepsis. All these conditions increase the extravascular water content. The aim of this study was to analyze the relationship between IAP and body water volume.
  
  
  METHODS
  Adult patients treated for sepsis or septic shock with acute kidney injury (AKI) and patients undergoing elective pharyngolaryngeal or orthopedic surgery were enrolled. IAP was measured in the urinary bladder. Total body water (TBW), extracellular water content (ECW) and volume excess (VE) were measured by whole body bioimpedance. Among critically ill patients, all parameters were analyzed over three consecutive days, and parameters were evaluated perioperatively in surgical patients.
  
  
  RESULTS
  One hundred twenty patients were studied. Taken together, the correlations between IAP and VE, TBW, and ECW were measured at 408 time points. In all participants, IAP strongly correlated with ECW and VE. In critically ill patients, IAP correlated with ECW and VE. In surgical patients, IAP correlated with ECW and TBW. IAP strongly correlated with ECW and VE in the mixed population. IAP also correlated with VE in critically ill patients. ROC curve analysis showed that ECW and VE might be discriminative parameters of risk for increased IAP.
  
  
  CONCLUSIONS
  IAP strongly correlates with ECW.
authors: Department of Anesthesiology and Intensive Therapy Medical University of Lublin, Lublin, Poland.
authors: Wojciech
authors: W
authors: Dąbrowski
authors: Department of Anesthesiology and Intensive Therapy Medical University of Lublin, Lublin, Poland.
authors: Edyta
authors: E
authors: Kotlinska-Hasiec
authors: Department of Family Medicine Medical University of Lublin, Lublin, Poland.
authors: Andrzej
authors: A
authors: Jaroszynski
authors: Department of Anesthesiology and Intensive Therapy Medical University of Lublin, Lublin, Poland.
authors: Przemyslaw
authors: P
authors: Zadora
authors: Department of General Surgery, Transplantology and Clinical Nutrition Medical University of Lublin, Lublin, Poland.
authors: Jacek
authors: J
authors: Pilat
authors: Department of Anesthesiology and Intensive Therapy Medical University of Lublin, Lublin, Poland.
authors: Ziemowit
authors: Z
authors: Rzecki
authors: Department of Nephrology Medical University of Lublin, Lublin, Poland.
authors: Wojciech
authors: W
authors: Zaluska
authors: Department of Physiology, Medical University of Graz, Graz, Austria.
authors: Daniel
authors: D
authors: Schneditz
mesh_terms: D000328:Adult; D017097:Electric Impedance; D005110:Extracellular Space / Q000378:metabolism*; D005260:Female; D006801:Humans; D059325:Intra-Abdominal Hypertension / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water