title: Locoregionally advanced nasopharyngeal carcinoma in childhood and adolescence: Analysis of 95 patients treated with combined chemotherapy and intensity-modulated radiotherapy.
abstract: The purpose of this study was to evaluate the treatment outcomes and toxicities of intensity-modulated radiation therapy (IMRT) for children and adolescents with locoregionally advanced nasopharyngeal carcinoma (NPC).
  
  
  
  Ninety-five patients of <25 years old in locoregionally advanced NPC (stage III-IVB) were analyzed. All were given neoadjuvant chemotherapy followed by IMRT with or without concurrent chemotherapy/adjuvant chemotherapy.
  
  
  
  The 4-year overall survival (OS), locoregional relapse-free survival, progression-free survival (PFS), and distant metastasis-free survival (DMFS) were 90.8%, 94.9%, 79.1%, and 84.0%, respectively. N classification was the only significant predicting factor for OS, PFS, and DMFS, with the p value of .017, .015, and 0.054, respectively. The main long-term complications were xerostomia, hearing impairment, and neck fibrosis.
  
  
  
  Neoadjuvant chemotherapy followed by IMRT with or without concurrent/adjuvant chemotherapy produced a superb treatment outcome in children and adolescents with stage III to IVB disease. Distant metastasis was the main failure. More effective treatment strategies are urgently needed to further improve the long-term survival. © 2015 Wiley Periodicals, Inc. Head Neck 38: E665-E672, 2016.
authors: Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China.|Provincial Clinical College, Fujian Medical University, Fuzhou, Fujian, China.|Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China.
authors: Qiaojuan
authors: Q
authors: Guo
authors: Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China.|Provincial Clinical College, Fujian Medical University, Fuzhou, Fujian, China.|Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China.
authors: Xiaofei
authors: X
authors: Cui
authors: Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China.|Provincial Clinical College, Fujian Medical University, Fuzhou, Fujian, China.|Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China.
authors: Shaojun
authors: S
authors: Lin
authors: Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China.|Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China.
authors: Jin
authors: J
authors: Lin
authors: Department of Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China.|Provincial Clinical College, Fujian Medical University, Fuzhou, Fujian, China.|Fujian Provincial Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China.
authors: Jianji
authors: J
authors: Pan
mesh_terms: D000293:Adolescent; D002277:Carcinoma / Q000628:therapy*; D059248:Chemoradiotherapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000628:therapy*; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D015996:Survival Rate
keywords: chemoradiation; children and adolescents; intensity-modulated radiation therapy; nasopharyngeal carcinoma; toxicities