title: Rh(I)-Catalyzed Hydroamidation of Olefins via Selective Activation of N-H Bonds in Aliphatic Amines.
abstract: Hydroamidation of olefins constitutes an ideal, atom-efficient method to prepare carboxylic amides from easily available olefins, CO, and amines. So far, aliphatic amines are not suitable for these transformations. Here, we present a ligand- and additive-free Rh(I) catalyst as solution to this problem. Various amides are obtained in good yields and excellent regioselectivities. Notably, chemoselective amidation of aliphatic amines takes place in the presence of aromatic amines and alcohols. Mechanistic studies reveal the presence of Rh-acyl species as crucial intermediates for the selectivity and rate-limiting step in the proposed Rh(I)-catalytic cycle.
authors: †Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein Str. 29a, 18059 Rostock, Germany.
authors: Kaiwu
authors: K
authors: Dong
authors: †Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein Str. 29a, 18059 Rostock, Germany.
authors: Xianjie
authors: X
authors: Fang
authors: †Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein Str. 29a, 18059 Rostock, Germany.
authors: Ralf
authors: R
authors: Jackstell
authors: ‡Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
authors: Gabor
authors: G
authors: Laurenczy
authors: †Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein Str. 29a, 18059 Rostock, Germany.
authors: Yuehui
authors: Y
authors: Li
authors: †Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein Str. 29a, 18059 Rostock, Germany.
authors: Matthias
authors: M
authors: Beller