title: Reactivation of antibiosis in the entomogenous fungus Chrysoporthe sp. SNB-CN74.
abstract: Chrysoporthe sp. SNB-CN74 was isolated from a Nasutitermes corniger nest, and its ethyl acetate extract was found to exhibit very strong antibacterial activity. Two antibacterial metabolites were isolated, (-)-R-skyrin (2) and (+)-rugulosin A (3). Eventually, the fungus lost its antibiotic potential when subcultured, and the use of yeast extract induced the re-expression of these two antibiotics. Yeast extract possibly activated a cryptic pathway by mimicking the presence of an ecological competitor.
authors: Department of Natural Products and Medicinal Chemistry, CNRS - Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France.|CNRS, UMR ECOFOG, Institut Pasteur de la Guyane, Cayenne, France.
authors: Charlotte
authors: C
authors: Nirma
authors: Department of Natural Products and Medicinal Chemistry, CNRS - Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France.
authors: Véronique
authors: V
authors: Eparvier
authors: Department of Natural Products and Medicinal Chemistry, CNRS - Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France.|Sorbonne Universités, UPMC Univ Paris 06, CNRS, Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique, Banyuls-sur-mer, France.
authors: Didier
authors: D
authors: Stien
mesh_terms: D000085:Acetates / Q000737:chemistry; D000818:Animals; D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000898:Antibiosis; D001203:Ascomycota / Q000302:isolation & purification / Q000378:metabolism*; D020049:Isoptera / Q000382:microbiology; D008826:Microbial Sensitivity Tests
chemical_list: D000085:Acetates; D000880:Anthraquinones; D000900:Anti-Bacterial Agents; C550228:rugulosin A; C007650:ethyl acetate; C009274:skyrin