title: The genomic and genetic toolbox of the teleost medaka (Oryzias latipes).
abstract: The Japanese medaka, Oryzias latipes, is a vertebrate teleost model with a long history of genetic research. A number of unique features and established resources distinguish medaka from other vertebrate model systems. A large number of laboratory strains from different locations are available. Due to a high tolerance to inbreeding, many highly inbred strains have been established, thus providing a rich resource for genetic studies. Furthermore, closely related species native to different habitats in Southeast Asia permit comparative evolutionary studies. The transparency of embryos, larvae, and juveniles allows a detailed in vivo analysis of development. New tools to study diverse aspects of medaka biology are constantly being generated. Thus, medaka has become an important vertebrate model organism to study development, behavior, and physiology. In this review, we provide a comprehensive overview of established genetic and molecular-genetic tools that render medaka fish a full-fledged vertebrate system.
authors: Centre for Organismal Studies, University of Heidelberg, INF 230, 69120 Heidelberg, Germany.
authors: Stephan
authors: S
authors: Kirchmaier
authors: Laboratory of Bioresources, National Institute for Basic Biology, Okazaki 444-8585, Aichi, Japan.
authors: Kiyoshi
authors: K
authors: Naruse
authors: Centre for Organismal Studies, University of Heidelberg, INF 230, 69120 Heidelberg, Germany felix.loosli@kit.edu Jochen.Wittbrodt@cos.uni-heidelberg.de.
authors: Joachim
authors: J
authors: Wittbrodt
authors: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76344 Eggenstein-Leopoldshafen, Germany felix.loosli@kit.edu Jochen.Wittbrodt@cos.uni-heidelberg.de.
authors: Felix
authors: F
authors: Loosli
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics; D005818:Genetic Engineering / Q000379:methods; D016678:Genome; D006824:Hybridization, Genetic; D009990:Oryzias / Q000235:genetics*
keywords: Oryzias latipes; genetics; genomics; medaka; teleost