title: [The APJ receptor: a new therapeutic approach in diabetic treatment].
abstract: The APJ receptor cloned in 1993 found its ligand in 1998 with the discovery of apelin. The presence of APJ in the central nervous system (more particularly in the hypothalamus) and in various tissues (heart, blood vessels, stomach, etc.) makes it a potential pharmacological target. Interest in APJ has allowed the development of peptidic molecules able to stimulate and/or inhibit the receptor and, more recently, to discover another endogenous ligand: apela. Among the functions regulated by the APJ/apelin system, the control of energy metabolism appears today in the forefront. A better understanding of the pharmacology of APJ receptor should allow innovative therapeutic approaches in the treatment of metabolic diseases.
authors: Institut des maladies métaboliques et cardiovasculaires, Inserm U1048, université Paul Sabatier, 1, avenue Jean Poulhès, 31432 Toulouse Cedex 4, France.
authors: Bernard
authors: B
authors: Masri
authors: Institut des maladies métaboliques et cardiovasculaires, Inserm U1048, université Paul Sabatier, 1, avenue Jean Poulhès, 31432 Toulouse Cedex 4, France.
authors: Cédric
authors: C
authors: Dray
authors: Institut des maladies métaboliques et cardiovasculaires, Inserm U1048, université Paul Sabatier, 1, avenue Jean Poulhès, 31432 Toulouse Cedex 4, France.
authors: Claude
authors: C
authors: Knauf
authors: Institut des maladies métaboliques et cardiovasculaires, Inserm U1048, université Paul Sabatier, 1, avenue Jean Poulhès, 31432 Toulouse Cedex 4, France.
authors: Philippe
authors: P
authors: Valet
authors: Institut des maladies métaboliques et cardiovasculaires, Inserm U1048, université Paul Sabatier, 1, avenue Jean Poulhès, 31432 Toulouse Cedex 4, France.
authors: Isabelle
authors: I
authors: Castan-Laurell
mesh_terms: D000818:Animals; D000073861:Apelin; D000075244:Apelin Receptors; D003920:Diabetes Mellitus / Q000628:therapy*; D004734:Energy Metabolism / Q000187:drug effects / Q000235:genetics; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology / Q000502:physiology; D051379:Mice; D058990:Molecular Targeted Therapy; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: C115436:APLN protein, human; C104575:APLNR protein, human; D000073861:Apelin; D000075244:Apelin Receptors; D036341:Intercellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled