title: Exploring the role of curcumin containing ethanolic extract obtained from Curcuma longa (rhizomes) against retardation of wound healing process by aspirin.
abstract: OBJECTIVE
  The aim of the study was to assess the curcumin containing ethanolic extract (EtOH) obtained from Curcuma longa (Cl) against retardation of wound healing by aspirin.
  
  
  METHODS
  Wound healing process was retarded by administering the dose of 150 mg/kg body weight of aspirin orally for 9 days to observe the effect of EtOH obtained from Cl using excision and incision wound model in rats. The various parameters such as % wound contraction, epithelialization period, hydroxyproline, tensile strength were observed at variant time intervals and histopathological study was also performed.
  
  
  RESULTS
  Curcumin containing 5% and 10% ethanolic extract ointment have shown significant (P < 0.01) wound healing activity against an aspirin (administered 150 mg/kg body weight orally for 9 days) retarded wound healing process. Topical application of ointment showed significant (P < 0.01) difference as compared to the control group. Histopathological studies also showed healing of the epidermis, increased collagen, fibroblasts and blood vessels.
  
  
  CONCLUSIONS
  Ethanolic extract of Cl ointment (EtOHCl) containing 10% curcumin displayed remarkable healing process against wound retardation by aspirin.
authors: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, Madhya Pradesh, India.
authors: Rajesh Singh
authors: RS
authors: Pawar
authors: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, Madhya Pradesh, India.
authors: Fedelic Ashish
authors: FA
authors: Toppo
authors: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, Madhya Pradesh, India.
authors: Avinash Singh
authors: AS
authors: Mandloi
authors: Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, VNS Group of Institutions, Bhopal, Madhya Pradesh, India.
authors: Shabnam
authors: S
authors: Shaikh
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D002855:Chromatography, Thin Layer; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000008:administration & dosage / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000431:Ethanol / Q000737:chemistry; D005260:Female; D008297:Male; D009824:Ointments; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D027343:Rhizome / Q000737:chemistry; D023422:Skin Irritancy Tests; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009824:Ointments; D010936:Plant Extracts; D000431:Ethanol; D003474:Curcumin; D001241:Aspirin
keywords: Aspirin; Curcuma longa; excision wound; incision wound; wound contraction