title: Acute disseminated encephalomyelitis associated with positive voltage gated potassium channel complex antibody.
abstract: Voltage gated potassium channel (VGKC) complex antibodies are associated with encephalopathies both in adult and children. The incidence of antibodies in the central nervous system demyelinating disorders is increasingly reported although their direct pathogenic role remains to be evaluated, with the exception of Aquaporin 4 antibodies. Here we describe a case of a 28 month old boy presenting with acute disseminated encephalomyelitis, with positive VGKC-complex antibodies and low sodium levels. He was treated with steroids and made a clinical and radiological recovery with normalisation of antibody levels.
authors: Paediatric Neurosciences, Evelina Children's Hospital at Guys and St Thomas' NHS Foundation Trust, Kings Health Partners Academic Health Science Centre, London, UK.
authors: Marios
authors: M
authors: Kaliakatsos
authors: Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors: Yael
authors: Y
authors: Hacohen
authors: Department of Radiology, Evelina Children's Hospital at Guys and St Thomas' NHS Foundation Trust, Kings Health Partners Academic Health Science Centre, London, UK.
authors: Ata
authors: A
authors: Siddiqui
authors: Paediatric Neurosciences, Evelina Children's Hospital at Guys and St Thomas' NHS Foundation Trust, Kings Health Partners Academic Health Science Centre, London, UK.
authors: Nomazulu
authors: N
authors: Dlamini
authors: Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.
authors: Angela
authors: A
authors: Vincent
authors: Paediatric Neurosciences, Evelina Children's Hospital at Guys and St Thomas' NHS Foundation Trust, Kings Health Partners Academic Health Science Centre, London, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address: Ming.lim@gstt.nhs.uk.
authors: Ming
authors: M
authors: Lim
keywords: Acute demyelination syndrome; Acute disseminated encephalomyelitis; Autoantibodies; Brainstem demyelination; Brainstem encephalitis; Voltage gated potassium channel complex antibodies