title: Bacterial recognition pathways that lead to inflammasome activation.
abstract: Inflammasomes are multi-protein signaling platforms that upon activation trigger the maturation of the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18, and cell death. Inflammasome sensors detect microbial and host-derived molecules. Here, we review the mechanisms of inflammasome activation triggered by bacterial infection, primarily focusing on two model intracellular bacterial pathogens, Francisella novicida and Salmonella typhimurium. We discuss the complex relationship between bacterial recognition through direct and indirect detection by inflammasome sensors. We highlight regulation mechanisms that potentiate or limit inflammasome activation. We discuss the importance of caspase-1 and caspase-11 in host defense, and we examine the downstream consequences of inflammasome activation within the context of bacterial infections.
authors: Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
authors: Kelly M
authors: KM
authors: Storek
authors: Denise M
authors: DM
authors: Monack
mesh_terms: D000818:Animals; D020170:Caspase 1 / Q000378:metabolism; D020169:Caspases / Q000378:metabolism; D053471:Caspases, Initiator / Q000378:metabolism; D005603:Francisella / Q000276:immunology*; D016905:Gram-Negative Bacterial Infections / Q000276:immunology*; D006801:Humans; D007109:Immunity; D058847:Inflammasomes / Q000276:immunology / Q000378:metabolism*; D020382:Interleukin-18 / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism*; D051379:Mice; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D012486:Salmonella typhimurium / Q000276:immunology*
chemical_list: D058847:Inflammasomes; D020382:Interleukin-18; D053583:Interleukin-1beta; D051192:Receptors, Pattern Recognition; C093516:CASP4 protein, human; C101136:Casp4 protein, mouse; D020169:Caspases; D053471:Caspases, Initiator; D020170:Caspase 1
keywords: Toll-like receptors/pattern recognition receptors; bacterial disease; cytotoxicity; inflammation; monocytes/macrophages; signaling proteins