title: Treatment of Crohn's disease and familial Mediterranean fever by leukopheresis: single shot for two targets.
abstract: Coexistence of Crohn's disease (CD) and familial Mediterranean fever (FMF) is a rare condition and knowledge about this clinical situation is limited with a few case reports in the literature. The treatment of both diseases depends on their individual therapies. However, it is very hard to deal with this coexistence when CD is refractory to standard therapies. Ongoing activity of CD triggers the clinical attacks of FMF and the symptoms like abdominal pain interfere with both disease presentations which can cause problems about diagnostic and therapeutic approach. The main therapeutic agent for FMF is colchicine and diarrhea is the most common side effect of this drug. This side effect also causes problems about management of these diseases when both of them are clinically active. Here we report probably the first case in the literature with coexisting CD and FMF who was successfully treated by leukopheresis since he was refractory to conventional therapies for CD.
authors: Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ankara 06230, Turkey.
authors: Mahmut
authors: M
authors: Yuksel
authors: Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ankara 06230, Turkey.
authors: Fatih
authors: F
authors: Saygili
authors: Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ankara 06230, Turkey.
authors: Orhan
authors: O
authors: Coskun
authors: Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ankara 06230, Turkey.
authors: Nuretdin
authors: N
authors: Suna
authors: Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ankara 06230, Turkey.
authors: Mustafa
authors: M
authors: Kaplan
authors: Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ankara 06230, Turkey.
authors: Ufuk Baris
authors: UB
authors: Kuzu
authors: Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ankara 06230, Turkey.
authors: Zeki Mesut Yalin
authors: ZM
authors: Kilic
authors: Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ankara 06230, Turkey.
authors: Yasemin Ozderin
authors: YO
authors: Ozin
authors: Mahmut Yuksel, Fatih Saygili, Orhan Coskun, Nuretdin Suna, Mustafa Kaplan, Ufuk Baris Kuzu, Zeki Mesut Yalin Kilic, Yasemin Ozderin Ozin, Ertugrul Kayacetin, Department of Gastroenterology, Turkiye Yuksek Ihtisas Training and Education Hospital, Ankara 06230, Turkey.
authors: Ertugrul
authors: E
authors: Kayacetin
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D010505:Familial Mediterranean Fever / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D007937:Leukapheresis; D008297:Male; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents
keywords: Crohn’s disease; Familial Mediterranean fever; Leukopheresis