title: Indoor total volatile organic compounds exposure at 6 months followed by atopic dermatitis at 3 years in children.
abstract: BACKGROUND
  Exposure to indoor air pollutants is thought to cause allergic inflammation. Volatile organic compounds (VOCs) are one of the aggravating factors of asthma and other allergic diseases. However, the influence of VOCs on development of atopic dermatitis is ambiguous in the clinical field. We therefore investigated the associations of indoor total volatile organic compounds (TVOCs) and development of atopic dermatitis in young Korean children.
  
  
  METHODS
  From the birth cohort of a MOthers and Children's Environmental Health (MOCEH) study, 257 infants, whose parents agreed with the environmental measurement, were enrolled. Total VOCs were measured in infant's bedrooms at the age of 6 month. A total of 105 parents answered a questionnaire at 36 month. Concentrations of TVOCs were divided into two groups by third quartile (75th). Associations between the high VOCs exposure group and development of atopic dermatitis at the age of 36 months were estimated by multivariate logistic regression.
  
  
  RESULTS
  The average concentration of TVOCs was 174.7 ± 115.1 ㎍/m(3) . We defined the high TVOCs exposure group by those with more than 75 percentile of the distribution (242.1 ㎍/m(3) ). An increased risk of atopic dermatitis was observed in the high TVOCs exposure group, after adjustment for parents history of allergy, household income, breast-feeding longer than 6 month (OR = 3.116, 95% Cl 1.041-9.323). Risk of atopic dermatitis was increased when the family bought new furniture within 1 yr.
  
  
  CONCLUSIONS
  Our results showed that exposure to high concentration of VOCs during infancy, an indoor pollutant, increased the risk of atopic dermatitis at 36 months.
authors: Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea.
authors: Jung Hyun
authors: JH
authors: Kwon
authors: Department of Preventive Medicine and Ewha Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Korea.
authors: Eunjeong
authors: E
authors: Kim
authors: Department of Preventive Medicine and Ewha Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Korea.
authors: Moon-Hee
authors: MH
authors: Chang
authors: Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea.
authors: Eun Ae
authors: EA
authors: Park
authors: Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: Yun-Chul
authors: YC
authors: Hong
authors: Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Korea.
authors: Mina
authors: M
authors: Ha
authors: Department of Preventive Medicine and Ewha Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Korea.
authors: Hyesook
authors: H
authors: Park
authors: Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
authors: Yangho
authors: Y
authors: Kim
authors: Environmental Health Research Division, National Institute of Environmental Research, Incheon, South Korea.
authors: Choonghee
authors: C
authors: Park
authors: Department of Preventive Medicine and Ewha Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Korea.
authors: Eun-Hee
authors: EH
authors: Ha
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects* / Q000706:statistics & numerical data*; D002675:Child, Preschool; D015331:Cohort Studies; D003876:Dermatitis, Atopic / Q000453:epidemiology*; D004781:Environmental Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007723:Korea / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D011795:Surveys and Questionnaires; D055549:Volatile Organic Compounds / Q000009:adverse effects*
chemical_list: D055549:Volatile Organic Compounds
keywords: atopic dermatitis; child; volatile organic compounds