title: Theragnostic imaging using radiolabeled antibodies and tyrosine kinase inhibitors.
abstract: During the past decade, the efficacy of new molecular targeted drugs such as tyrosine kinase inhibitors (TKIs) and monoclonal antibodies has been proven worldwide, and molecular targeted therapies have become the mainstream in cancer therapy. However, clinical use of these new drugs presents unexpected adverse effects or poor therapeutic effects. Therefore, we require diagnostic tools to estimate the target molecule status in cancer tissues and predict therapeutic efficacy and adverse effects. Although immunohistochemical, polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH) analyses of biopsy samples are conventional and popular for this diagnostic purpose, molecular imaging modalities such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) are also useful for noninvasive estimation of gene and protein expression and drug pharmacokinetics. In this review, we introduce new radiolabeled TKIs, antibodies, and their clinical application in molecular targeted therapy and discuss the issues of these imaging probes.
authors: Division of Functional Imaging, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
authors: Mitsuyoshi
authors: 0000-0003-2083-9148
authors: M
authors: Yoshimoto
authors: Diagnostic Radiology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors: Hiroaki
authors: H
authors: Kurihara
authors: Division of Functional Imaging, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.
authors: Hirofumi
authors: H
authors: Fujii
mesh_terms: D000906:Antibodies / Q000494:pharmacology*; D003952:Diagnostic Imaging; D006801:Humans; D009154:Mutation / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D019275:Radiopharmaceuticals / Q000494:pharmacology*; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D000906:Antibodies; D047428:Protein Kinase Inhibitors; D019275:Radiopharmaceuticals