title: Efficacy of intralesional recombinant human epidermal growth factor in chronic diabetic foot ulcers.
abstract: OBJECTIVE
  The aim of this study was to explore the clinical effects of intralesional administration of an epidermal growth factor (EGF) up to complete wound closure.
  
  
  METHODS
  Seventeen diabetic patients with full-thickness lower extremity ulcers of more than 4 weeks of evolution were enrolled in the study. Mean ulcer size was 15.5 +/- 7.5 cm(2). Intralesional injections of 75 µg of Heberprot-P three times per week for 5-8 weeks were given up to complete wound healing.
  
  
  RESULTS
  Full granulation response was achieved in all patients in 32.4 +/- 6.6 days. Complete wound closure was obtained in 16 (94.1%) cases in 53.1 +/- 4.7 days. The most frequent adverse events were burning sensation, tremors, chills and pain at the site of administration. After 1-year follow-up, only one patient relapsed.
  
  
  CONCLUSIONS
  Intralesional EGF administration up to complete closure can be safe, effective and suitable to improve healing of chronic diabetic foot ulcer (DFU).
authors: Department of Cardiovascular Surgery, Medical Park Gebze Hospital , Istanbul , Turkey and.
authors: Mert
authors: M
authors: Dumantepe
authors: Osman
authors: O
authors: Fazliogullari
authors: Mustafa
authors: M
authors: Seren
authors: Ibrahim
authors: I
authors: Uyar
authors: Fahrettin
authors: F
authors: Basar
mesh_terms: D000368:Aged; D017719:Diabetic Foot / Q000188:drug therapy*; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D011994:Recombinant Proteins; D004815:Epidermal Growth Factor
keywords: Amputation and epidermal growth factor; diabetic foot ulcers; wound healing