title: The alteration of gray matter volume and cognitive control in adolescents with internet gaming disorder.
abstract: OBJECTIVE
  Internet gaming disorder (IGD) has been investigated by many behavioral and neuroimaging studies, for it has became one of the main behavior disorders among adolescents. However, few studies focused on the relationship between alteration of gray matter volume (GMV) and cognitive control feature in IGD adolescents.
  
  
  METHODS
  Twenty-eight participants with IAD and twenty-eight healthy age and gender matched controls participated in the study. Brain morphology of adolescents with IGD and healthy controls was investigated using an optimized voxel-based morphometry (VBM) technique. Cognitive control performances were measured by Stroop task, and correlation analysis was performed between brain structural change and behavioral performance in IGD group.
  
  
  RESULTS
  The results showed that GMV of the bilateral anterior cingulate cortex (ACC), precuneus, supplementary motor area (SMA), superior parietal cortex, left dorsal lateral prefrontal cortex (DLPFC), left insula, and bilateral cerebellum decreased in the IGD participants compared with healthy controls. Moreover, GMV of the ACC was negatively correlated with the incongruent response errors of Stroop task in IGD group.
  
  
  CONCLUSIONS
  Our results suggest that the alteration of GMV is associated with the performance change of cognitive control in adolescents with IGD, which indicating substantial brain image effects induced by IGD.
authors: Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University Xi'an, China.
authors: Hongmei
authors: H
authors: Wang
authors: Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University Xi'an, China.
authors: Chenwang
authors: C
authors: Jin
authors: School of Life Science and Technology, Xidian University Xi'an, China ; Engineering Research Center of Molecular and Neuro Imaging Ministry of Education Xi'an, China.
authors: Kai
authors: K
authors: Yuan
authors: Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University Xi'an, China.
authors: Tahir Mehmood
authors: TM
authors: Shakir
authors: Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University Xi'an, China.
authors: Cuiping
authors: C
authors: Mao
authors: Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University Xi'an, China.
authors: Xuan
authors: X
authors: Niu
authors: Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University Xi'an, China.
authors: Chen
authors: C
authors: Niu
authors: Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University Xi'an, China.
authors: Liping
authors: L
authors: Guo
authors: Department of Medical Imaging, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University Xi'an, China.
authors: Ming
authors: M
authors: Zhang
keywords: anterior cingulate cortex; cognitive control; color-word stroop; gray matter; internet addiction disorder