title: Rebound Thrombocytosis following Induction Chemotherapy is an Independent Predictor of a Good Prognosis in Acute Myeloid Leukemia Patients Attaining First Complete Remission.
abstract: There are very few data about the relationship between acute myeloid leukemia (AML) prognosis and bone marrow recovery kinetics following chemotherapy. In this study, we aimed to assess the prognostic importance and clinical associations of neutrophil and platelet recovery rates and rebound thrombocytosis (RT) or neutrophilia (RN) in the postchemotherapy period for newly diagnosed AML patients. De novo AML patients diagnosed between October 2002 and December 2013 were evaluated retrospectively. One hundred patients were suitable for inclusion. Cox regression analysis using need for reinduction chemotherapy as a stratification parameter revealed RT as the only parameter predictive of OS, with borderline statistical significance (p = 0.06, OR = 7; 95% CI 0.92-53), and it was the only parameter predictive of DFS (p = 0.024, OR = 10; 95% CI 1.3-75). In order to understand whether RT or RN was related to a better marrow capacity or late consolidation, we considered neutrophil recovery time and platelet recovery time and nadir-first consolidation durations in all patients in the cohort. Both the marrow recovery duration and the time between marrow aplasia and first consolidation were shorter in RT and RN patients. To our knowledge, this is the first study to report a correlation between RT/RN and prognosis in AML.
authors: Department of Hematology, School of Medicine, Hacettepe University, Ankara, Turkey.
authors: Umit Yavuz
authors: UY
authors: Malkan
authors: Gursel
authors: G
authors: Gunes
authors: Ayse
authors: A
authors: Isik
authors: Eylem
authors: E
authors: Eliacik
authors: Sezgin
authors: S
authors: Etgul
authors: Tuncay
authors: T
authors: Aslan
authors: Muruvvet Seda
authors: MS
authors: Balaban
authors: Ibrahim Celalettin
authors: IC
authors: Haznedaroglu
authors: Haluk
authors: H
authors: Demiroglu
authors: Hakan
authors: H
authors: Goker
authors: Osman Ilhami
authors: OI
authors: Ozcebe
authors: Nilgun
authors: N
authors: Sayınalp
authors: Salih
authors: S
authors: Aksu
authors: Yahya
authors: Y
authors: Buyukasik
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D013922:Thrombocytosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy