title: Anti-AMPA receptor encephalitis associated with thymomatous myasthenia gravis.
abstract: No thymomatous myasthenia gravis (TMG) has been reported in patients with anti-α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor encephalitis (AMPAR-E). We described clinical presentation and autoimmune profile of the first case with both AMPAR-E and TMG. Clinical information was obtained from original medical records. Antibodies against AMPAR and confounding antigens were examined on transfected human embryonic kidney 293 cells by the indirect immunofluorescence method. In this case, anti-AMPAR antibodies and anti-acetylcholine receptor (AchR) antibodies were both positive and could explain the encephalitis and MG respectively. This report also indicated the complexity of autoimmunity network associated with thymoma. However, the relationships between thymoma, MG and AMPAR-E remained unclear.
authors: Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
authors: Xiang
authors: X
authors: Li
authors: Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
authors: Yi-Ting
authors: YT
authors: Mao
authors: Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
authors: Jian-Jun
authors: JJ
authors: Wu
authors: Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
authors: Lin-Xin
authors: LX
authors: Li
authors: Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: xiangjchen@fudan.edu.cn.
authors: Xiang-Jun
authors: XJ
authors: Chen
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D004660:Encephalitis / Q000097:blood* / Q000175:diagnosis; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood* / Q000175:diagnosis; D018091:Receptors, AMPA / Q000097:blood*; D013945:Thymoma / Q000097:blood* / Q000175:diagnosis; D013953:Thymus Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D001323:Autoantibodies; D018091:Receptors, AMPA
keywords: AMPA receptors; Autoimmune encephalitis; Myasthenia; Thymoma