title: Unprecedented one-pot synthesis of an unsymmetrical cisplatin-based Pt(IV)-acetamidato complex.
abstract: We describe herein a novel Pt(IV)-acetamidato complex as a result of the one-pot reaction between cisplatin and the highly reactive peroxyacetimidic acid generated in situ. This is the first example of a Pt(IV) complex containing a N-donor ligand coordinated during the Pt(II) → Pt(IV) oxidation step. Remarkably, the Pt(IV)-amidato compound is highly soluble and stable in water; it represents an interesting building block for the further development of Pt(IV) antitumor prodrugs.
authors: Dipartimento di Chimica, Università di Parma, Parco Area delle Scienze, 17/A, 43124 Parma, Italy.
authors: Giorgio
authors: G
authors: Pelosi
authors: Mauro
authors: M
authors: Ravera
authors: Elisabetta
authors: E
authors: Gabano
authors: Federico
authors: F
authors: Fregonese
authors: Domenico
authors: D
authors: Osella
mesh_terms: D000081:Acetamides / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D002945:Cisplatin / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000081:Acetamides; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D002945:Cisplatin