title: Evaluation of treatment response using integrated 18F-labeled choline positron emission tomography/magnetic resonance imaging in adolescents with intracranial non-germinomatous germ cell tumours.
abstract: The efficacy of hybrid 18F-Fluroethyl-Choline (FEC) positron emission tomography (PET)/magnetic resonance imaging (MRI) was investigated as an imaging modality for diagnosis and assessment of treatment response and remission status in four patients with proven or suspected intracranial non-germinomatous germ cell tumours (NGGCT). In two patients faint or absent choline avidity correlated with negative histology, whereas in other two patients, persistent choline avidity in the residual mass was suggestive of presence of viable tumour, subsequently confirmed histologically. We conclude that FEC-PET/MRI may be an effective imaging tool in detecting viable residual tumour in patients with intracranial NGGCT post treatment.
authors: Department of Pediatric & Adolescent Oncology, University College London Hospitals NHS Foundation Trust, UK.
authors: Eva
authors: E
authors: Tsouana
authors: Department of Pediatric & Adolescent Oncology, University College London Hospitals NHS Foundation Trust, UK.
authors: Sara
authors: S
authors: Stoneham
authors: Department of Oncology, University College London Hospitals NHS Foundation Trust, UK.
authors: Naomi
authors: N
authors: Fersht
authors: Department of Neurosurgery, University College London Hospitals NHS Foundation Trust, UK.
authors: Neil
authors: N
authors: Kitchen
authors: Department of Oncology, University College London Hospitals NHS Foundation Trust, UK.
authors: Mark
authors: M
authors: Gaze
authors: Institute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, UK.
authors: Jamshed
authors: J
authors: Bomanji
authors: Institute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, UK.
authors: Francesco
authors: F
authors: Fraioli
authors: Department of Pediatric Oncology, Great Ormond Street Hospital, UK.
authors: Darren
authors: D
authors: Hargrave
authors: Department of Pediatric & Adolescent Oncology, University College London Hospitals NHS Foundation Trust, UK.
authors: Ananth
authors: A
authors: Shankar
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D002551:Cerebral Ventricle Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D002794:Choline / Q000031:analogs & derivatives; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003399:Craniotomy; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging; D009373:Neoplasms, Germ Cell and Embryonal / Q000000981:diagnostic imaging* / Q000628:therapy; D059906:Neuroimaging / Q000379:methods*; D010870:Pineal Gland / Q000000981:diagnostic imaging; D010871:Pinealoma / Q000000981:diagnostic imaging* / Q000628:therapy; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; C514960:fluorocholine; D002794:Choline
keywords: 18F-fluoroethyl-choline; PET; choline; intracranial germ cell tumours; neuro-oncolgy; positron emission tomography