title: Two tales (tails) of SAMHD1 destruction by Vpx.
abstract: The lentivirus protein Vpx/Vpr recognizes the host restriction factor SAMHD1 at either its N- or C-terminal tail and targets it for destruction by the cellular protein degradation machinery. In this issue of Cell Host & Microbe, Schwefel et al. (2015) report the structural basis of SAMHD1 N-terminal targeting by Vpx.
authors: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
authors: Xiaoyun
authors: X
authors: Ji
authors: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. Electronic address: yong.xiong@yale.edu.
authors: Yong
authors: Y
authors: Xiong
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry*; D054884:Host-Pathogen Interactions; D020559:Monomeric GTP-Binding Proteins / Q000737:chemistry*; D055503:Protein Multimerization; D054334:Viral Regulatory and Accessory Proteins / Q000737:chemistry*
chemical_list: D002352:Carrier Proteins; D054334:Viral Regulatory and Accessory Proteins; D020559:Monomeric GTP-Binding Proteins