title: [Recent progress of the mechanisms for RNA viruses to block the recognition of dsRNA with RIG-I-like receptors].
abstract: RIG-I-like receptors (RLRs) belong to pattern recognition receptors, which perform significant roles in antiviral responses. RLRs can initiate a cascade of signaling transduction that induces the production of type I interferon and activates the interferon signaling pathway, ultimately resulting in antiviral responses. In the course of evolution, viruses have been constantly counteracting host immune systems to facilitate their own survival and replication, and have developed a set of antagonistic strategies. These mainly comprise elusion, disguise and attack strategies to eliminate the activation of RLRs. In virus-infected cells, RLRs recognize viral RNA and then induce antiviral responses. A better understanding of viral antagonistic strategies against RLRs will provide insights into the development of new antiviral medicines. This mini-review concludes that there are three main antagonistic strategies by which RNA viruses can counteract the activation of the RLRs pathway. It aims to provide references and insights for similar studies on viral antagonism in an array of RNA viruses.
authors: Guo-qing
authors: GQ
authors: Wang
authors: Zi-xiang
authors: ZX
authors: Zhu
authors: Wei-jun
authors: WJ
authors: Cao
authors: Lei
authors: L
authors: Liu
authors: Hai-xue
authors: HX
authors: Zheng
mesh_terms: D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000235:genetics / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D012328:RNA Viruses / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D012330:RNA, Double-Stranded / Q000235:genetics / Q000276:immunology*; D012367:RNA, Viral / Q000235:genetics / Q000276:immunology*; D011971:Receptors, Immunologic; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology / Q000821:virology*
chemical_list: D012330:RNA, Double-Stranded; D012367:RNA, Viral; D011971:Receptors, Immunologic; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases