title: Effect of royal jelly on formalin induced-inflammation in rat hind paw.
abstract: BACKGROUND
  Royal Jelly (RJ), a food item secreted by worker honeybees, is a mixture that contains protein, glucose, lipid, vitamins, and minerals; it is widely used as a commercial medical product. Previous studies have shown that RJ has a number of physiological effects, such as anti-inflammatory, antitumor, antiallergic and antioxidant activities.
  
  
  OBJECTIVE
  In the present study, the anti-inflammatory properties of RJ were investigated in formalin-induced rat paw edema.
  
  
  METHODS
  In this study, 30 male Wistar albino rats were divided into five equal groups (n = 6) as follows: test groups received different doses (25, 50 and 100 mg/kg, ip) of RJ and a negative control group received normal saline (5 mL/kg) and a positive control group received aspirin (300 mg/kg, i.p). Edema was induced on the right hind paw of the rat by a subplantar injection of 100 µL of formalin (2.5%) after 30 minutes. Paw edema was measured in the rats received the drugs, saline and aspirin before and after the formalin injection during 5 hours, using a plethysmometer.
  
  
  RESULTS
  The results showed that RJ has a dose-dependent anti-inflammatory effect and the highest anti-inflammatory effect was observed in the doses of 50 and 100 mg/kg.
  
  
  CONCLUSIONS
  Royal jelly has potent anti-inflammatory effects compared to aspirin and it could be used in the treatment of inflammation. However, further studies are required to determine the active components in RJ responsible for this effect and its mechanism of action.
authors: Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran ; Physiology Research Center, Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors: Ardeshir
authors: A
authors: Arzi
authors: Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors: Samaneh
authors: S
authors: Olapour
authors: Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors: Hamid
authors: H
authors: Yaghooti
authors: Department of Pharmacology and Toxicology, School of Pharmacy, Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
authors: Neda
authors: N
authors: Sistani Karampour
keywords: Formaldehyde; Inflammation; Rats; Royal Jelly