title: Clinical value of core length in contemporary multicore prostate biopsy.
abstract: OBJECTIVE
  There is little data about the clinical value of core length for prostate biopsy (PBx). We investigated the clinical values of various clinicopathological biopsy-related parameters, including core length, in the contemporary multi-core PBx.
  
  
  METHODS
  Medical records of 5,243 consecutive patients who received PBx at our institution were reviewed. Among them, 3,479 patients with prostate-specific antigen (PSA) ≤ 10 ng/ml level who received transrectal ultrasound (TRUS)-guided multi (≥ 12)-core PBx at our institution were analyzed for prostate cancer (PCa). Gleason score upgrading (GSU) was analyzed in 339 patients who were diagnosed with low-risk PCa and received radical prostatectomy. Multivariate logistic regression analyses for PCa detection and prediction of GSU were performed.
  
  
  RESULTS
  The mean age and PSA of the entire cohort were 63.5 years and 5.4 ng/ml, respectively. The overall cancer detection rate was 28.5%. There was no statistical difference in core length between patients diagnosed with PCa and those without PCa (16.1 ± 1.8 vs 16.1 ± 1.9 mm, P = 0.945). The core length was also not significantly different (16.4 ± 1.7 vs 16.4 ± 1.6mm, P = 0.889) between the GSU group and non-GSU group. Multivariate logistic regression analyses demonstrated that the core length of PBx did not affect PCa detection in TRUS-guided multi-core PBx (P = 0.923) and was not prognostic for GSU in patients with low-risk PCa (P = 0.356).
  
  
  CONCLUSIONS
  In patients undergoing contemporary multi-core PBx, core length may not have significant impact on PCa detection and also GSU following radical prostatectomy among low-risk PCa group.
authors: Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Sangchul
authors: S
authors: Lee
authors: Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Seong Jin
authors: SJ
authors: Jeong
authors: Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Sung Il
authors: SI
authors: Hwang
authors: Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Sung Kyu
authors: SK
authors: Hong
authors: Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Hak Jong
authors: HJ
authors: Lee
authors: Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Seok Soo
authors: SS
authors: Byun
authors: Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Gheeyoung
authors: G
authors: Choe
authors: Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea.
authors: Sang Eun
authors: SE
authors: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D011467:Prostate / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D012307:Risk Factors; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen