title: The role of myofibroblasts in wound healing, contraction and its clinical implications in cleft palate repair.
abstract: Myofibroblasts after its discovery in 1971 as the principal cell for wound healing has come a long way as far as research is concerned. The primary focus of research has been regarding preventing certain unwanted effects of this cell such as wound contraction and scarring. As far as the oral and maxillofacial region is concerned, the primary concern of this untoward effect is during repair of cleft palate surgically which results impaired development of palate and the dentoalveolar structures. This review focuses on the basic aspects of myofibroblasts such as its origin, formation, function in wound healing, role in wound contraction and ways by which its unwanted effects can be overcome to improve the quality of the post surgical complications of cleft palate surgery.
authors: Senior Lecturer, Department of Oral Pathology, Sibar Institute of Dental Sciences, Guntur, Andhra Pradesh, India.
authors: Ravi Teja
authors: RT
authors: Chitturi
authors: Senior Lecturer, Department of Oral Pathology, Sathyabama University Dental College and Hospital, Chennai, Tamil Nadu, India.
authors: A Murali
authors: AM
authors: Balasubramaniam
authors: Senior Lecturer, Department of Oral Pathology, Pushpagiri College of Dental Sciences, Thiruvalla, Kerala, India.
authors: R Arjun
authors: RA
authors: Parameswar
authors: Senior Lecturer, Department of Oral Pathology, Madha Dental College & Hospital, Kundrathur, Chennai, Tamil Nadu, India.
authors: G
authors: G
authors: Kesavan
authors: Senior Lecturer, Department of Oral Pathology, Malabar Dental College and Research Centre, Malappuram, Kerala, India.
authors: K T Muhamed
authors: KT
authors: Haris
authors: Senior Lecturer, Department of Oral Pathology, Sathyabama University Dental College and Hospital, Chennai, Tamil Nadu, India.
authors: Khadijah
authors: K
authors: Mohideen
keywords: Cleft palate; complications of wound healing; factors affecting myofibroblasts; myofibroblasts; wound healing