title: Lipid mediators are critical in resolving inflammation: a review of the emerging roles of eicosanoids in diabetes mellitus.
abstract: The biosynthesis pathway of eicosanoids derived from arachidonic acid, such as prostaglandins and leukotrienes, relates to the pathophysiology of diabetes mellitus (DM). A better understanding of how lipid mediators modulate the inflammatory process may help recognize key factors underlying the progression of diabetes complications. Our review presents recent knowledge about eicosanoid synthesis and signaling in DM-related complications, and discusses eicosanoid-related target therapeutics.
authors: Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 580, Bloco 17, 05508-000 São Paulo, SP, Brazil.
authors: Fernando H G
authors: FH
authors: Tessaro
authors: Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 580, Bloco 17, 05508-000 São Paulo, SP, Brazil.
authors: Thais S
authors: TS
authors: Ayala
authors: Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, Avenida Professor Lineu Prestes 580, Bloco 17, 05508-000 São Paulo, SP, Brazil.
authors: Joilson O
authors: JO
authors: Martins
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism*; D004537:Eicosanoic Acids / Q000378:metabolism*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D004537:Eicosanoic Acids; D018836:Inflammation Mediators