title: Impact of postoperative complications on survival and recurrence in pancreatic cancer.
abstract: BACKGROUND
  We investigated the impact of postoperative complications on survival and recurrence after curative surgery for pancreatic cancer.
  
  
  METHODS
  This study included 164 patients who underwent curative surgery for pancreatic cancer between 2005 and 2014. The patients were classified into those with postoperative complications (C group) and those without postoperative complications (NC group). The risk factors for overall survival (OS) and recurrence-free survival (RFS) were identified.
  
  
  RESULTS
  Postoperative complications were found in 61 out of the 164 patients (37.2%). The RFS rate at five years after surgery was 10.6% in the C group and 21.0% in the NC group. The RFS tended to be worse in the C group than in the NC group (p=0.1756). The OS rate at five years after surgery was 7.4% in the C group and 22.8% in the NC group, which was significantly different (p=0.0189). The multivariate analysis demonstrated that the occurrence of postoperative complications was a significant independent risk factor for OS and a marginally significant risk factor for RFS.
  
  
  CONCLUSIONS
  The development of postoperative complications was a risk factor for a decreased overall survival in the patients who underwent curative surgery for pancreatic cancer. The surgical procedure, perioperative care and the surgical strategy should be carefully planned to avoid complications.
authors: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan aoyamat@kcch.jp.
authors: Toru
authors: T
authors: Aoyama
authors: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors: Masaaki
authors: M
authors: Murakawa
authors: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors: Yusuke
authors: Y
authors: Katayama
authors: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors: Koichiro
authors: K
authors: Yamaoku
authors: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors: Amane
authors: A
authors: Kanazawa
authors: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors: Akio
authors: A
authors: Higuchi
authors: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors: Manabu
authors: M
authors: Shiozawa
authors: Department of Hepatobiliary and Pancreatic Oncology, Kanagawa Cancer Center, Yokohama, Japan.
authors: Manabu
authors: M
authors: Morimoto
authors: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors: Takaki
authors: T
authors: Yoshikawa
authors: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors: Naoto
authors: N
authors: Yamamoto
authors: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors: Yasushi
authors: Y
authors: Rino
authors: Department of Surgery, Yokohama City University, Yokohama, Japan.
authors: Munetaka
authors: M
authors: Masuda
authors: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
authors: Soichiro
authors: S
authors: Morinaga
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000473:pathology / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000473:pathology*
keywords: Pancreatic cancer; recurrence; surgical complication; survival