title: Role of IL-38 and its related cytokines in inflammation.
abstract: Interleukin- (IL-) 38 is a recently discovered cytokine and is the tenth member of the IL-1 cytokine family. IL-38 shares structural features with IL-1 receptor antagonist (IL-1Ra) and IL-36Ra. IL-36R is the specific receptor of IL-38, a partial receptor antagonist of IL-36. IL-38 inhibits the production of T-cell cytokines IL-17 and IL-22. IL-38 also inhibits the production of IL-8 induced by IL-36γ, thus inhibiting inflammatory responses. IL-38-related cytokines, including IL-1Ra and IL-36Ra, are involved in the regulation of inflammation and immune responses. The study of IL-38 and IL-38-related cytokines might provide new insights for developing anti-inflammatory treatments in the near future.
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, China.
authors: Xianli
authors: X
authors: Yuan
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, China.
authors: Xiao
authors: X
authors: Peng
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, China.
authors: Yan
authors: Y
authors: Li
authors: Zhejiang Provincial Key Laboratory of Pathophysiology, Department of Immunology, Ningbo University School of Medicine, Ningbo 315211, China.
authors: Mingcai
authors: M
authors: Li
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D053590:Interleukin 1 Receptor Antagonist Protein / Q000502:physiology; D007378:Interleukins / Q000737:chemistry / Q000502:physiology*; D018123:Receptors, Interleukin / Q000502:physiology; D015398:Signal Transduction
chemical_list: D016207:Cytokines; C571243:IL-38 protein, human; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007378:Interleukins; D018123:Receptors, Interleukin; C571244:interleukin-36 receptor, human