title: Association of HLA-B*5701 genotypes and abacavir-induced hypersensitivity reaction: a systematic review and meta-analysis.
abstract: OBJECTIVE
  This study aimed to systematically review and quantitatively synthesize the association between HLA-B*5701 and abacavir-induced hypersensitivity reaction (ABC-HSR).
  
  
  METHODS
  We searched for studies that investigated the association between HLA-B genotype and ABC-HSR and provided information about the frequency of carriers of HLA-B genotypes among cases and controls. We then performed a meta-analysis with a random-effects model to pool the data and to investigate the sources of heterogeneity.
  
  
  RESULTS
  From 1,026 articles identified, ten studies were included. Five using clinical manifestation as their diagnostic criteria, 409 and 1,883 subjects were included as cases and controls. Overall OR was 23.6 (95% CI = 15.4 - 36.3). Whereas, the another five studies using confirmed immunologic test as their diagnostic criteria, 110 and 1,968 subjects were included as cases and controls, respectively. The association of ABC-HSR was strong in this populations with HLA-B*5701. Overall OR was 1,056.2 (95% CI = 345.0 - 3,233.3).
  
  
  CONCLUSIONS
  Using meta-analysis technique, the association between HLA-B*5701 and ABC-HSR is strong in the studies using immunologic confirmation to identify ABC-HSR. These results support the US FDA recommendations for screening HLA-B*5701 allele before initiating abacavir therapy.
authors: Center of Excellence for Environmental Health & Toxicology; Pharmacokinetic Research Unit; Department of Pharmacy Practice.
authors: Wimonchat
authors: W
authors: Tangamornsuksan
authors: Ornrat
authors: O
authors: Lohitnavy
authors: Chuenjid
authors: C
authors: Kongkaew
authors: Nathorn
authors: N
authors: Chaiyakunapruk
authors: Brad
authors: B
authors: Reisfeld
authors: Norman Charles
authors: NC
authors: Scholfield
authors: Manupat
authors: M
authors: Lohitnavy
mesh_terms: D000483:Alleles; D019380:Anti-HIV Agents / Q000009:adverse effects; D015224:Dideoxynucleosides / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000235:genetics; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D000099227:Abacavir
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D000099227:Abacavir; C484830:HLA-B*57:01 antigen