title: Iron oxide nanoparticles for magnetically-guided and magnetically-responsive drug delivery.
abstract: In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release.
authors: Departament de Fisicoquímica; Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain. joanestelrich@ub.edu.
authors: Joan
authors: J
authors: Estelrich
authors: Departament de Farmàcia i Tecnologia Farmacèutica, Facultat de Farmàcia, Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain. eescribano@ub.edu.
authors: Elvira
authors: E
authors: Escribano
authors: Departament de Fisiologia, Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain. josepqueralt@ub.edu.
authors: Josep
authors: J
authors: Queralt
authors: Departament de Fisicoquímica; Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain. mabusquetsvinas@ub.edu.
authors: Maria Antònia
authors: MA
authors: Busquets
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D005290:Ferric Compounds / Q000737:chemistry*; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D008280:Magnetics / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D009696:Nucleic Acids / Q000235:genetics; D014162:Transfection / Q000379:methods
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D009696:Nucleic Acids; C000499:ferric oxide