title: Isoniazid induced convulsions at therapeutic dose in an alcoholic and smoker patient.
abstract: We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge as well as ruled out other conditions. Use of isoniazid in alcoholic and smoker patient required a caution for prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention of such adverse reaction.
authors: Amol S
authors: AS
authors: Aiwale
authors: Utkarsh A
authors: UA
authors: Patel
authors: Manish J
authors: MJ
authors: Barvaliya
authors: Pramod R
authors: PR
authors: Jha
authors: Department of Pharmacology, Government Medical College, Bhavnagar-364001, Gujarat, India. cbrtripathi@yahoo.co.in.
authors: Chandrabhanu
authors: C
authors: Tripathi
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications*; D000927:Anticonvulsants / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000009:adverse effects*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D011736:Pyridoxine / Q000627:therapeutic use; D012307:Risk Factors; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D012907:Smoking / Q000009:adverse effects*; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D000995:Antitubercular Agents; D014803:Vitamin B Complex; D011736:Pyridoxine; D007538:Isoniazid