title: A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics.
abstract: Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (P<0.0001). This association was replicated with an odds ratio of 5.1 in Italian population (P<0.0001); rs11125 predicted also increased serum level of total IgE in Spanish controls. These data are consistent with the predicted deleterious influence of Gln>His substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.
authors: INSERM U-954, University of Lorraine and University Hospital Center (CHU) of Nancy, Nancy, France.|Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.|Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors: J A
authors: JA
authors: Cornejo-García
authors: Department of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Complesso Integrato Columbus, Rome and IRCCS Oasi Maria S.S., Troina, Italy.
authors: A
authors: A
authors: Romano
authors: INSERM U-954, University of Lorraine and University Hospital Center (CHU) of Nancy, Nancy, France.
authors: R M
authors: RM
authors: Guéant-Rodríguez
authors: INSERM U-954, University of Lorraine and University Hospital Center (CHU) of Nancy, Nancy, France.
authors: A
authors: A
authors: Oussalah
authors: Allergy Service, Infanta Leonor Hospital, Madrid, Spain.
authors: N
authors: N
authors: Blanca-López
authors: Department of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Complesso Integrato Columbus, Rome and IRCCS Oasi Maria S.S., Troina, Italy.
authors: F
authors: F
authors: Gaeta
authors: INSERM U-954, University of Lorraine and University Hospital Center (CHU) of Nancy, Nancy, France.
authors: D
authors: D
authors: Tramoy
authors: INSERM U-954, University of Lorraine and University Hospital Center (CHU) of Nancy, Nancy, France.
authors: T
authors: T
authors: Josse
authors: Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors: I
authors: I
authors: Doña
authors: Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors: M J
authors: MJ
authors: Torres
authors: Allergy Service, Infanta Leonor Hospital, Madrid, Spain.
authors: G
authors: G
authors: Canto
authors: Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain.
authors: M
authors: M
authors: Blanca
authors: INSERM U-954, University of Lorraine and University Hospital Center (CHU) of Nancy, Nancy, France.
authors: J-L
authors: JL
authors: Guéant
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001798:Blood Proteins; D016022:Case-Control Studies; D004342:Drug Hypersensitivity / Q000235:genetics*; D005091:Exons; D005260:Female; D037502:Galectin 3 / Q000235:genetics*; D037161:Galectins; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics; D007073:Immunoglobulin E / Q000097:blood; D007558:Italy; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017434:Protein Structure, Tertiary; D013030:Spain; D047090:beta-Lactams / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D037502:Galectin 3; D037161:Galectins; C428445:LGALS3 protein, human; D047090:beta-Lactams; D007073:Immunoglobulin E