title: Oxidative stress and adipocyte biology: focus on the role of AGEs.
abstract: Diabetes is a major health problem that is usually associated with obesity, together with hyperglycemia and increased advanced glycation endproducts (AGEs) formation. Elevated AGEs elicit severe downstream consequences via their binding to receptors of AGEs (RAGE). This includes oxidative stress and oxidative modifications of biological compounds together with heightened inflammation. For example, albumin (major circulating protein) undergoes increased glycoxidation with diabetes and may represent an important biomarker for monitoring diabetic pathophysiology. Despite the central role of adipose tissue in many physiologic/pathologic processes, recognition of the effects of greater AGEs formation in this tissue is quite recent within the obesity/diabetes context. This review provides a brief background of AGEs formation and adipose tissue biology and thereafter discusses the impact of AGEs-adipocyte interactions in pathology progression. Novel data are included showing how AGEs (especially glycated albumin) may be involved in hyperglycemia-induced oxidative damage in adipocytes and its potential links to diabetes progression.
authors: UMR DéTROI, Inserm U1188 Diabète Athérothrombose Thérapies Réunion Océan Indien, Université de La Réunion, Plateforme CYROI, Saint Denis de La Réunion, France.
authors: Florence
authors: F
authors: Boyer
authors: UMR DéTROI, Inserm U1188 Diabète Athérothrombose Thérapies Réunion Océan Indien, Université de La Réunion, Plateforme CYROI, Saint Denis de La Réunion, France.
authors: Jennifer Baraka
authors: JB
authors: Vidot
authors: UMR DéTROI, Inserm U1188 Diabète Athérothrombose Thérapies Réunion Océan Indien, Université de La Réunion, Plateforme CYROI, Saint Denis de La Réunion, France.
authors: Alexis Guerin
authors: AG
authors: Dubourg
authors: UMR DéTROI, Inserm U1188 Diabète Athérothrombose Thérapies Réunion Océan Indien, Université de La Réunion, Plateforme CYROI, Saint Denis de La Réunion, France.
authors: Philippe
authors: P
authors: Rondeau
authors: Cardio-Metabolic Research Group (CMRG), Department of Physiological Sciences, Stellenbosch University, Stellenbosch, South Africa.
authors: M Faadiel
authors: MF
authors: Essop
authors: UMR DéTROI, Inserm U1188 Diabète Athérothrombose Thérapies Réunion Océan Indien, Université de La Réunion, Plateforme CYROI, Saint Denis de La Réunion, France.
authors: Emmanuel
authors: 0000-0003-3731-150X
authors: E
authors: Bourdon
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism / Q000473:pathology; D007791:Lactoylglutathione Lyase / Q000378:metabolism; D018384:Oxidative Stress; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D007791:Lactoylglutathione Lyase