title: The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
abstract: P. aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a complex biological system, renders ineffective the clearance by immune defense systems and antibiotherapy. The objective of this report is to provide an overview (i) on P. aeruginosa biofilm lifestyle cycle, (ii) on the main key actors relevant in the regulation of biofilm formation by P. aeruginosa including QS systems, GacS/GacA and RetS/LadS two-component systems and C-di-GMP-dependent polysaccharides biosynthesis, and (iii) finally on reported natural and synthetic products that interfere with control mechanisms of biofilm formation by P. aeruginosa without affecting directly bacterial viability. Concluding remarks focus on perspectives to consider biofilm lifestyle as a target for eradication of resistant infections caused by P. aeruginosa.
authors: Laboratory of Plant Biotechnology, Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.
authors: Tsiry
authors: 0000-0002-0049-2856
authors: T
authors: Rasamiravaka
authors: Laboratory of Plant Biotechnology, Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.
authors: Quentin
authors: 0000-0001-5340-5624
authors: Q
authors: Labtani
authors: Department of Therapeutical Chemistry and Pharmacognosy, Université de Mons, Avenue Maistriau 19, Bâtiment Mendeleiev, 7000 Mons, Belgium.
authors: Pierre
authors: 0000-0002-0484-1478
authors: P
authors: Duez
authors: Laboratory of Plant Biotechnology, Université Libre de Bruxelles, rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium.
authors: Mondher
authors: 0000-0001-5787-6319
authors: M
authors: El Jaziri
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D018441:Biofilms / Q000254:growth & development*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D011552:Pseudomonas Infections / Q000382:microbiology* / Q000473:pathology; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000254:growth & development*
chemical_list: D001426:Bacterial Proteins; C091100:GacA protein, Bacteria; C507835:RetS protein, Pseudomonas aeruginosa