title: Networking in the nucleus: a spotlight on LEM-domain proteins.
abstract: Proteins resident in the inner nuclear membrane and underlying nuclear lamina form a network that regulates nuclear functions. This review highlights a prominent family of nuclear lamina proteins that carries the LAP2-emerin-MAN1-domain (LEM-D). LEM-D proteins share an ability to bind lamins and tether repressive chromatin at the nuclear periphery. The importance of this family is underscored by findings that loss of individual LEM-D proteins causes progressive, tissue-restricted diseases, known as laminopathies. Diverse functions of LEM-D proteins are linked to interactions with unique and overlapping partners including signal transduction effectors, transcription factors and architectural proteins. Recent investigations suggest that LEM-D proteins form hubs within the nuclear lamina that integrate external signals important for tissue homeostasis and maintenance of progenitor cell populations.
authors: Department of Biochemistry, University of Iowa, College of Medicine, Iowa City, IA 52242, USA; Skirball Institute, Department of Cell Biology, NYU School of Medicine, NYU Langone Medical Center, New York, NY 10016, USA.
authors: Lacy J
authors: LJ
authors: Barton
authors: Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY, 10065, USA.
authors: Alexey A
authors: AA
authors: Soshnev
authors: Department of Biochemistry, University of Iowa, College of Medicine, Iowa City, IA 52242, USA. Electronic address: pamela-geyer@uiowa.edu.
authors: Pamela K
authors: PK
authors: Geyer
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism*; D010641:Phenotype; D017434:Protein Structure, Tertiary; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D002843:Chromatin; D009687:Nuclear Proteins; D014157:Transcription Factors