title: IgG4-related disease manifesting as pericarditis with elevated adenosine deaminase and IL-10 levels in pericardial fluid.
abstract: A 78-year-old female with massive pericardial effusion fulfilled diagnostic criteria for immunoglobulin G4 (IgG4)-related disease. Although her adenosine deaminase (ADA) level in the pericardial effusion was high, all the tests for tuberculosis infection were negative. Immunostaining of the pericardium biopsy specimen revealed remarkably increased IgG4-positive cells. This is the first report describing IgG4-related pericarditis with elevated ADA level. We also demonstrate the elevated interleukin-10 (IL-10) level in pericardial fluid and IL-10-producing T-cells in the pericardium.
authors: a Department of Rheumatology and Clinical Immunology , Kobe University Graduate School of Medicine , Chuo-ku, Kobe , Japan.
authors: Sho
authors: S
authors: Sendo
authors: a Department of Rheumatology and Clinical Immunology , Kobe University Graduate School of Medicine , Chuo-ku, Kobe , Japan.
authors: Jun
authors: J
authors: Saegusa
authors: b Department of Diagnostic Pathology , Kobe University Graduate School of Medicine , Chuo-ku, Kobe , Japan.
authors: Yukiko
authors: Y
authors: Morinaga
authors: b Department of Diagnostic Pathology , Kobe University Graduate School of Medicine , Chuo-ku, Kobe , Japan.
authors: Fumi
authors: F
authors: Kawakami
authors: a Department of Rheumatology and Clinical Immunology , Kobe University Graduate School of Medicine , Chuo-ku, Kobe , Japan.
authors: Yoshinori
authors: Y
authors: Kogata
authors: a Department of Rheumatology and Clinical Immunology , Kobe University Graduate School of Medicine , Chuo-ku, Kobe , Japan.
authors: Goichi
authors: G
authors: Kageyama
authors: a Department of Rheumatology and Clinical Immunology , Kobe University Graduate School of Medicine , Chuo-ku, Kobe , Japan.
authors: Akio
authors: A
authors: Morinobu
mesh_terms: D000243:Adenosine Deaminase / Q000032:analysis*; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D016753:Interleukin-10 / Q000032:analysis*; D008297:Male; D062072:Patient Acuity; D010490:Pericardial Effusion / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D000069236:Pericardial Fluid / Q000276:immunology*; D010493:Pericarditis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D010495:Pericarditis, Tuberculous / Q000175:diagnosis*; D010496:Pericardium / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D016753:Interleukin-10; D000243:Adenosine Deaminase
keywords: Adenosine deaminase; IL-10; IgG4-related disease; Pericarditis