title: Body temperature sensitive micelles for MRI enhancement.
abstract: A novel thermo-sensitive micelle contrast agent and its enhancement of MRI contrast with temperature are reported. The morphology changes sharply near 37 °C, resulting in a significant amplification of the CEST signal. This enables detection of small changes in body temperature.
authors: Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center of Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. xinzhou@wipm.ac.cn.
authors: Xiaolei
authors: X
authors: Zhu
authors: Shizhen
authors: S
authors: Chen
authors: Qing
authors: Q
authors: Luo
authors: Chaohui
authors: C
authors: Ye
authors: Maili
authors: M
authors: Liu
authors: Xin
authors: X
authors: Zhou
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D001831:Body Temperature; D003287:Contrast Media / Q000737:chemistry; D056831:Coordination Complexes / Q000737:chemistry; D005063:Europium / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008689:Methacrylates / Q000737:chemistry; D008823:Micelles
chemical_list: D000178:Acrylamides; D003287:Contrast Media; D056831:Coordination Complexes; D006573:Heterocyclic Compounds, 1-Ring; D008689:Methacrylates; D008823:Micelles; C509363:poly(N-isopropylacrylamide-b-methyl methacrylate); C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D005063:Europium