title: Peptide aptamers: development and applications.
abstract: Peptide aptamers are small combinatorial proteins that are selected to bind to specific sites on their target molecules. Peptide aptamers consist of short, 5-20 amino acid residues long sequences, typically embedded as a loop within a stable protein scaffold. Various peptide aptamer scaffolds and in vitro and in vivo selection techniques are reviewed with emphasis on specific biomedical, bioimaging, and bioanalytical applications.
authors: Sergey
authors: S
authors: Reverdatto
authors: David S
authors: DS
authors: Burz
authors: Department of Chemistry, State University of New York at Albany, 14oo Washington Ave., Albany, NY, USA. ashekhtman@albany.edu.
authors: Alexander
authors: A
authors: Shekhtman
mesh_terms: D000906:Antibodies / Q000737:chemistry; D052158:Aptamers, Peptide / Q000737:chemistry* / Q000494:pharmacology; D051186:Armadillo Domain Proteins / Q000737:chemistry; D019020:Directed Molecular Evolution / Q000379:methods*; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D008958:Models, Molecular; D057054:Molecular Imaging / Q000379:methods; D019151:Peptide Library; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D052156:SELEX Aptamer Technique / Q000379:methods*; D020798:Two-Hybrid System Techniques
chemical_list: D000906:Antibodies; D052158:Aptamers, Peptide; D051186:Armadillo Domain Proteins; D019151:Peptide Library