title: Development of a Double-Lumen Cannula for a Percutaneous RVAD.
abstract: The objectives were to design/fabricate a double-lumen cannula (DLC) for a percutaneous right ventricular assist device (pRVAD) and to test the feasibility/performance of this pRVAD system. A 27 Fr DLC prototype was made and tested in six adult sheep. The pRVAD DLC was inserted into the right jugular vein; advanced through the superior vena cava, the right atrium (RA), the right ventricle (RV); ending in the pulmonary artery (PA). A CentriMag pump and optional gas exchanger were connected to the DLC. Blood was withdrawn from RA, pumped through gas exchanger, and perfused PA. Maximal pumping flow was maintained for 2 hours. The pRVAD DLC was successfully deployed in all six sheep. In first three sheep, maximal average pumping flow was less than 3 L/min because the DLC was advanced too far with drainage opening against RA side wall. In last three sheep with well-positioned DLC, average maximal flow was more than 3.5 L/min. The gas exchanger provided up to 230 ml/min CO2 removal and 174 ml/min O2 transfer. Our DLC-based pRVAD system is feasible for percutaneous right heart and respiratory assistance through a single cannulation. The pRVAD DLC can be easily placed prophylactically during left ventricular assist device implantation and removed as needed without additional open chest procedures.
authors: From the *Cardiothoracic Surgery Division, Department of Surgery, University of Kentucky, Lexington, Kentucky; and †W-Z Biotech LLC, Lexington, Kentucky.
authors: Dongfang
authors: D
authors: Wang
authors: Cameron
authors: C
authors: Jones
authors: Cherry
authors: C
authors: Ballard-Croft
authors: Ju
authors: J
authors: Zhao
authors: Guangfeng
authors: G
authors: Zhao
authors: Stephen
authors: S
authors: Topaz
authors: Joseph B
authors: JB
authors: Zwischenberger
mesh_terms: D000818:Animals; D057785:Catheters; D004867:Equipment Design; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology*; D023421:Models, Animal; D034561:Sheep, Domestic