title: Occurrence of pesticide residues and transformation products in different types of dietary supplements.
abstract: The purpose of this study was to evaluate the presence of pesticide residues and transformation products in dietary supplement products. Thirty-two samples were analysed to determine 177 pesticides by gas chromatography-tandem mass spectrometry (GC-MS/MS) and 333 pesticides by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Pesticides were extracted from different kinds of dietary supplements by the use of a modified QuEChERS extraction method. Six samples contained pesticide residues at concentration up to 92.7 µg kg(-1), but only butralin exceeded the maximum residue limits set for raw material. In addition to target compounds, LC-HRMS enables the simultaneous detection of non-target pesticides. In this case, transformation products of pesticides were detected in the analysed samples using HRMS analyser (Exactive-Orbitrap). These compounds were not included in the original method, and they were monitored as post-target compounds, knowing their molecular formula and exact mass. Mass accuracy was always < 2 ppm, corresponding to a maximum mass error. The positive findings endorse the idea that a deeper and continuous investigation of pesticide residues and transformation products in dietary supplement products is necessary in order to guaranty consumer's safety.
authors: a Resarch Group "Analytical Chemistry of Contaminants", Department of Chemistry and Physics, Research Centre for Agricultural and Food Biotechnology (BITAL) , University of Almería, Agrifood Campus of International Excellence , Almería , Spain.
authors: Agneša
authors: A
authors: Páleníková
authors: Gerardo
authors: G
authors: Martínez-Domínguez
authors: Francisco Javier
authors: FJ
authors: Arrebola
authors: Roberto
authors: R
authors: Romero-González
authors: Svetlana
authors: S
authors: Hrouzková
authors: Antonia
authors: A
authors: Garrido Frenich
mesh_terms: D002853:Chromatography, Liquid; D003257:Consumer Product Safety; D019587:Dietary Supplements / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D010573:Pesticide Residues / Q000032:analysis*
chemical_list: D010573:Pesticide Residues
keywords: Exactive-Orbitrap; GC-QqQ-MS/MS; dietary supplements; pesticides; transformation products