title: Investigation on the IL-18 -607A/C and -137C/G on the susceptibility of ischemic stroke.
abstract: OBJECTIVE
  We conducted a case-control study with 322 cases and 322 controls to assess the role of the two common SNPs in the promoter of IL-18 gene.
  
  
  METHODS
  Polymerase chain reaction restriction fragment length of polymorphism (PCR-RFLP) was taken to genotype -607A/C and -137C/G in the promoter of the IL-18 gene.
  
  
  RESULTS
  By comparing cases and control subjects, we found that IS cases were more likely to have higher BMI, higher proportion of hypertension, and have higher proportion of smokers and drinkers. We found that IL-18 -607CC genotype (OR=1.70, 95% CI=1.03-2.81) and C allele (OR=1.26, 95% CI=1.01-1.58) were significantly more frequent in IS patients when compared with AA genotype. We did not find significant association between IL-18 -607A/C gene polymorphism and BMI, hypertension, smoking and drinking on the risk of IS.
  
  
  CONCLUSIONS
  Our study suggests that polymorphisms in IL-18 -607A/C can influence the development of IS, and this gene polymorphism is associated with risk of IS in a Chinese population.
authors: Jin-he Shi, Department of Emergency, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors: Jin-He
authors: JH
authors: Shi
authors: Li-dan Niu, Department of Emergency, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors: Li-Dan
authors: LD
authors: Niu
authors: Xi-yan Chen, Department of Emergency, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors: Xi-Yan
authors: XY
authors: Chen
authors: Jing-yu Hou, Department of Emergency, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors: Jing-Yu
authors: JY
authors: Hou
authors: Ping Yang, Department of Emergency, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors: Ping
authors: P
authors: Yang
authors: Guang-Peng Li, Department of Emergency, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
authors: Guang-Peng
authors: GP
authors: Li
keywords: IL-18; Ischemic stroke; Polymorphism