title: [The becoming of fatty cells, biological function of trophology, biological reactions of exo- and endotrophy in phylogenesis. The functional difference between visceral fatty cells and subcutaneous adipocytes].
abstract: The becoming of visceral fatty, cells in phylogenesis occurred many billions years before subcutaneous adipocytes. The pool of visceral fatty cells realizes biologic functions of trophology and homeostasis, endoecology, and adaptation from the early stages of phylogenesis. The subcutaneous adipocytes realize phylogenetically late biologic function of locomotion. The visceral fatty cells have no receptors to insulin and all subcutaneous adipocytes are insulin-dependent. In biologic function of trophology, both visceral fatty cells and subcutaneous adipocytes realize biologic reaction of exotrophy, biologic reaction of depositing and biologic reaction of endotrophy. It is supposed that the most common cause of obesity is disorder of biologic reaction of depositing of fatty acids in form of triglycerides. It is considered as a basis of that dysfunction of visceral fatty cells (metabolic syndrome) and insulin-dependent adipocytes (obesity) takes so often a character of metabolic pandemic. The fatty cells absorb fatty acids in form of non-polar triglycerides, deposit them in lipid drops and free fatty acids into intercelluar medium in form of polar unesterified fatty acids. The visceral fatty cells had been formed in paracrin cenosis of enterocytes and in it microsome protein transferring triglycerides formed early type of chylomicrons. The visceral fatty cells and adipocytles are phylogenetically, regulatory, functionally and pathophysiologically different cells. Therefore, they are to be considered separately. Not only visceral fatty cells and adipocytes but all cells of areolar tissue at level of cenosis of cells secrete many humoral mediators of paracrin regulation. The other modes of regulation are unknown. Leptin is a specific mediator of visceral fatty cells and adiponectin is a mediator of subcutaneous adipocytes.
authors: V N
authors: VN
authors: Titov
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D052242:Adiponectin / Q000235:genetics / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D050152:Intra-Abdominal Fat / Q000166:cytology / Q000378:metabolism*; D020738:Leptin / Q000235:genetics / Q000378:metabolism*; D009765:Obesity / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D050151:Subcutaneous Fat / Q000166:cytology*
chemical_list: D052242:Adiponectin; D005230:Fatty Acids, Nonesterified; D020738:Leptin