title: Prognostic value, clinicopathologic features and diagnostic accuracy of interleukin-8 in colorectal cancer: a meta-analysis.
abstract: BACKGROUND
  The prognostic value and diagnostic accuracy of Interleukin-8 (IL-8) in colorectal cancer have been assessed with several studies, but the conclusions were inconclusive. Thus we performed a meta-analysis to evaluate the impact of IL-8 expression on colorectal cancer prognosis, clinicopathologic features and diagnostic accuracy.
  
  
  METHODS
  Comprehensive search strategies were used to search relevant literature in the PubMed, EBSCO and the ISI Web of Science databases. The correlation between IL-8 expression and prognosis, clinicopathologic features and diagnostic accuracy was analyzed.
  
  
  RESULTS
  A total of 18 articles met the inclusion criteria, including 1509 patients for clinicopathologic features or prognosis evaluation and 725 participants for diagnostic evaluation. The results suggested that overexpression of IL-8 was significantly associated with poor prognosis in colorectal cancer (HR = 1.54, 95%CI 1.03-2.32), especially in Union for International Cancer Control (UICC) stage IV patients (HR = 2.28, 95%CI 1.60-3.25). With further subgroup analysis, we found that high IL-8 level in serum was significantly correlated with poor prognosis (HR = 2.13, 95%CI 1.49-3.05). In addition, significant correlations were observed between high IL-8 expression and advanced stage (OR = 3.01, 95%CI 1.98-4.56), lymphatic metastasis (OR = 2.24, 95%CI 1.39-3.63), and liver metastasis (OR = 3.47, 95%CI 1.74-6.89). Moreover, IL-8 had high diagnostic accuracy, with pooled sensitivity 0.70(95%CI 0.66-0.74), specificity 0.91(95%CI 0.86-0.94), positive likelihood ratio (LR) 7.00(95%CI 2.48-19.73), negative LR 0.24(95%CI 0.09-0.64), diagnostic OR 24.00(95%CI 5.52-104.38).
  
  
  CONCLUSIONS
  This study showed that IL-8 could be a potential indicator for detecting colorectal cancer and predicting prognosis. In addition, high IL-8 level was significantly correlated with advanced stage, lymphatic metastasis, liver metastasis.
authors: Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Institute, Key Laboratory of Cancer Prevention&Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
authors: Wenjie
authors: W
authors: Xia
authors: Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Institute, Key Laboratory of Cancer Prevention&Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
authors: Wuzhen
authors: W
authors: Chen
authors: Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Institute, Key Laboratory of Cancer Prevention&Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
authors: Zhigang
authors: Z
authors: Zhang
authors: Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Institute, Key Laboratory of Cancer Prevention&Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
authors: Dang
authors: D
authors: Wu
authors: Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Institute, Key Laboratory of Cancer Prevention&Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
authors: Pin
authors: P
authors: Wu
authors: Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Institute, Key Laboratory of Cancer Prevention&Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
authors: Zhigang
authors: Z
authors: Chen
authors: Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors: Chao
authors: C
authors: Li
authors: Department of Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Cancer Institute, Key Laboratory of Cancer Prevention&Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
authors: Jian
authors: J
authors: Huang
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D016013:Likelihood Functions; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D016017:Odds Ratio; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D016209:Interleukin-8