title: The thioredoxin/peroxiredoxin/sulfiredoxin system: current overview on its redox function in plants and regulation by reactive oxygen and nitrogen species.
abstract: In plants, the presence of thioredoxin (Trx), peroxiredoxin (Prx), and sulfiredoxin (Srx) has been reported as a component of a redox system involved in the control of dithiol-disulfide exchanges of target proteins, which modulate redox signalling during development and stress adaptation. Plant thiols, and specifically redox state and regulation of thiol groups of cysteinyl residues in proteins and transcription factors, are emerging as key components in the plant response to almost all stress conditions. They function in both redox sensing and signal transduction pathways. Scarce information exists on the transcriptional regulation of genes encoding Trx/Prx and on the transcriptional and post-transcriptional control exercised by these proteins on their putative targets. As another point of control, post-translational regulation of the proteins, such as S-nitrosylation and S-oxidation, is of increasing interest for its effect on protein structure and function. Special attention is given to the involvement of the Trx/Prx/Srx system and its redox state in plant signalling under stress, more specifically under abiotic stress conditions, as an important cue that influences plant yield and growth. This review focuses on the regulation of Trx and Prx through cysteine S-oxidation and/or S-nitrosylation, which affects their functionality. Some examples of redox regulation of transcription factors and Trx- and Prx-related genes are also presented.
authors: Department of Stress Biology and Plant Pathology, CEBAS-CSIC, Campus Universitario de Espinardo, 30100 Murcia, Spain fsevilla@cebas.csic.es.
authors: F
authors: F
authors: Sevilla
authors: Department of Stress Biology and Plant Pathology, CEBAS-CSIC, Campus Universitario de Espinardo, 30100 Murcia, Spain.
authors: D
authors: D
authors: Camejo
authors: Department of Stress Biology and Plant Pathology, CEBAS-CSIC, Campus Universitario de Espinardo, 30100 Murcia, Spain.
authors: A
authors: A
authors: Ortiz-Espín
authors: Department of Stress Biology and Plant Pathology, CEBAS-CSIC, Campus Universitario de Espinardo, 30100 Murcia, Spain.
authors: A
authors: A
authors: Calderón
authors: Department of Biochemistry, Cellular and Molecular Biology of Plants, EEZ, CSIC, 18007 Granada, Spain.
authors: J J
authors: JJ
authors: Lázaro
authors: Department of Stress Biology and Plant Pathology, CEBAS-CSIC, Campus Universitario de Espinardo, 30100 Murcia, Spain.
authors: A
authors: A
authors: Jiménez
mesh_terms: D010084:Oxidation-Reduction; D050862:Oxidoreductases Acting on Sulfur Group Donors / Q000378:metabolism; D054464:Peroxiredoxins / Q000378:metabolism; D018521:Plant Physiological Phenomena; D010940:Plant Proteins / Q000378:metabolism*; D026361:Reactive Nitrogen Species / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D015398:Signal Transduction; D013879:Thioredoxins / Q000378:metabolism
chemical_list: D010940:Plant Proteins; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D013879:Thioredoxins; D054464:Peroxiredoxins; D050862:Oxidoreductases Acting on Sulfur Group Donors
keywords: Peroxiredoxin; S-nitrosylation; S-oxidation; redox gene regulation; signalling; sulfiredoxin; thioredoxin.