title: Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro.
abstract: A new terthiophene, 3'-hydroxy-2,2':5',2″-terthiophene-3'-O-β-D-glucopyranoside (1) and a new oleanane-type saponin, echinocystic acid-3-O-(6-O-acetyl)-β-D-glucopyranoside (7) were isolated from the aerial parts of Eclipta prostrata L. Moreover, five thiophenes (2-6), seven triterpenoids (8-14), two coumestans (15 and 16), and four flavonoids (17-20) having previously known chemical structures were isolated during the same course of this study. All the isolates 1-20 were evaluated for their cytotoxicity against human ovarian cancer cells (SKOV3) using MTT assays.
authors: Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea.
authors: Ha-Yeong
authors: HY
authors: Kim
authors: College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea.
authors: Hye Mi
authors: HM
authors: Kim
authors: Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea.
authors: Byeol
authors: B
authors: Ryu
authors: Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea.
authors: Jae-Seung
authors: JS
authors: Lee
authors: Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea.|College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea.
authors: Jung-Hye
authors: JH
authors: Choi
authors: Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea. dsjang@khu.ac.kr.|College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea. dsjang@khu.ac.kr.
authors: Dae Sik
authors: DS
authors: Jang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D036601:Eclipta / Q000737:chemistry*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: Cytotoxicity; Eclipta prostrata; Ovarian cancer; Terthiophene; Triterpenoid