title: Concomitant protective and therapeutic role of verapamil in chronic mercury induced nephrotoxicity in the adult rat: histological, morphometric and ultrastructural study.
abstract: BACKGROUND
  Mercury intoxication is a widespread problem as mercury is used in the manufacture of thermometers, batteries and electrical switches. It forms one of the most diffusible environmental pollutants. Mercury has a nephrotoxic effect which could occur at low exposure levels. Verapamil could help in the treatment of mercuric toxicity. The aim of the study was to examine the protective and therapeutic effect of concomitant verapamil on chronic mercuric chloride nephrotoxicity. This was done through histological, morphometric and transmission electron microscopic studies.
  
  
  METHODS
  Sixty adult male albino rats were used. The rats were divided into a control group and 4 experimental groups: group I (HgCl2), group II (concomitant HgCl2 and verapamil), group III (HgCl2 withdrawal) and group IV (HgCl2 withdrawal then verapamil treatment).
  
  
  RESULTS
  Chronic administration of HgCl2 resulted in cortical nephrotoxic effects in the form of glomerular sclerosis, acute tubular necrosis and interstitial inflammatory cellular infiltration which eventually ended in interstitial fibrosis. Concomitant use of verapamil with HgCl2 improved the previous pathological changes partially. The findings in group III were less severe compared to group IV. The persistence of the pathological findings in these groups reflects the irreversible nephrotoxic changes caused by chronic HgCl2 exposure.
  
  
  CONCLUSIONS
  We concluded that the concomitant administration of verapamil has a much better effect in minimizing the nephrotoxic effect caused by chronic HgCl2 than its therapeutic administration. So, we recommended the prophylactic use of verapamil in suspected cases of chronic mercuric chloride nephrotoxicity to preserve renal function.
authors: Department of Anatomy, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors: Nabila Yousef Abdel
authors: NY
authors: Haleem
authors: Department of Anatomy, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors: Hoda Mahmoud
authors: HM
authors: El-Aasar
authors: Department of Anatomy, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors: Sherif Mohamed
authors: SM
authors: Zaki
authors: Department of Anatomy, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors: Sherif Mohamed
authors: SM
authors: Sabry
authors: Department of Anatomy, Faculty of Medicine, Cairo University, Cairo, Egypt.
authors: Ahmed Wafiq
authors: AW
authors: El-Zainy
keywords: verapamil chronic mercury nephrotoxicity