title: Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis.
abstract: We aimed to investigate the role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis. Blood samples were collected from 216 patients receiving hemodialysis treatment. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype IL-6 -634C/G, -174G/C and -572C/G. By multivariate analysis, we found that the IL-6 -634GG genotype was associated with increased risk of cardiovascular events in patients receiving hemodialysis, with HR (95%CI) of 4.07 (1.20-15.70). Similarly, we found that the IL-6-174CC genotype was related to the onset and development of cardiovascular events in patients receiving hemodialysis, with HR (95%CI) of 3.33 (1.21-9.51). However, we did not find an association between IL-6 -572C/G polymorphism and risk of cardiovascular events in patients receiving hemodialysis.
authors: Department of Nephrology, People's Hospital of Rizhao, Shandong, China.
authors: Y
authors: Y
authors: Song
authors: Department of Nephrology, People's Hospital of Rizhao, Shandong, China.
authors: H D
authors: HD
authors: Gu
authors: Department of Nephrology, People's Hospital of Rizhao, Shandong, China.
authors: Y
authors: Y
authors: He
authors: Department of Nephrology, People's Hospital of Rizhao, Shandong, China.
authors: J W
authors: JW
authors: Wang
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D006435:Renal Dialysis; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D015850:Interleukin-6