title: c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis.
abstract: Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (JNK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore a possible mechanism of action of JNK signaling pathway in glaucoma-induced retinal optic nerve damage. We established a mouse model of chronic ocular hypertension by reducing the aqueous humor followed by photocoagulation using the laser ignition method. Results showed significant pathological changes in the ocular tissues after the injury. Apoptosis of retinal ganglion cells increased with increased intraocular pressure, as did JNK3 mRNA expression in the retina. These data indicated that the increased expression of JNK3 mRNA was strongly associated with the increase in intraocular pressure in the retina, and correlated positively with the apoptosis of retinal ganglion cells.
authors: Department of Ophthalmology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors: Yue
authors: Y
authors: He
authors: Department of Rheumatology and Immunology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors: Jie
authors: J
authors: Chen
authors: Department of Ophthalmology, the Second People's Hospital of Zhengzhou City, Zhengzhou, Henan Province, China.
authors: Shu-Guang
authors: SG
authors: Zhang
authors: Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors: Yuan-Sheng
authors: YS
authors: Yuan
authors: Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors: Yan
authors: Y
authors: Li
authors: Department of Ophthalmology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors: Hong-Bin
authors: HB
authors: Lv
authors: Department of Ophthalmology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China.
authors: Jin-Hua
authors: JH
authors: Gan
keywords: JNK3; glaucoma; intraocular pressure; laser photocoagulation; nerve regeneration; neural regeneration; ocular hypertension; retinal ganglion cell