title: Clinical next generation sequencing of pediatric-type malignancies in adult patients identifies novel somatic aberrations.
abstract: Pediatric malignancies in adults, in contrast to the same diseases in children are clinically more aggressive, resistant to chemotherapeutics, and carry a higher risk of relapse. Molecular profiling of tumor sample using next generation sequencing (NGS) has recently become clinically available. We report the results of targeted exome sequencing of six adult patients with pediatric-type malignancies : Wilms tumor(n=2), medulloblastoma(n=2), Ewing's sarcoma( n=1) and desmoplastic small round cell tumor (n=1) with a median age of 28.8 years. Detection of druggable somatic aberrations in tumors is feasible. However, identification of actionable target therapies in these rare adult patients with pediatric-type malignancies is challenging. Continuous efforts to establish a rare disease registry are warranted.
authors: Division of Pediatrics, The University of Texas MD Anderson Children's Cancer Hospital, Houston, TX.
authors: Jorge Galvez
authors: JG
authors: Silva
authors: Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Miami-Miller School of Medicine, Miami, FL.
authors: Fernando F
authors: FF
authors: Corrales-Medina
authors: Division of Pediatrics, The University of Texas MD Anderson Children's Cancer Hospital, Houston, TX.
authors: Ossama M
authors: OM
authors: Maher
authors: Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
authors: Nizar
authors: N
authors: Tannir
authors: Division of Pediatrics, The University of Texas MD Anderson Children's Cancer Hospital, Houston, TX.
authors: Winston W
authors: WW
authors: Huh
authors: Division of Pediatrics, The University of Texas MD Anderson Children's Cancer Hospital, Houston, TX.
authors: Michael E
authors: ME
authors: Rytting
authors: Division of Pediatrics, The University of Texas MD Anderson Children's Cancer Hospital, Houston, TX ; Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
authors: Vivek
authors: V
authors: Subbiah
keywords: Next generation sequencing; Solid Tumors; Somatic Mutation