title: Melatonin exerts protective effect on N2a cells under hypoxia conditions through Zip1/ERK pathway.
abstract: Melatonin plays a neuroprotective role in different CNS injuries. However, the molecular mechanisms underlying neuroprotection by melatonin are not well understood. Here, we studied the effects of melatonin in hypoxia-induced N2a cells and our results demonstrated that melatonin not only reduced the level of ROS and MDA, induced the increase of SOD, but also increased the cell proliferation and inhibited cell apoptosis in hypoxia-induced N2a cells. Moreover, we identified that melatonin can activate the MAPK/ERK pathway via upregulating the expression of Zip1. Therefore, this study provides a new mechanism of melatonin and need our further study in detail.
authors: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Rescue Center of Severe Wound and Trauma of PLA, Shenyang, 110016 Liaoning Province, China.
authors: Xin-Wei
authors: XW
authors: Liu
authors: Department of Emergency, 463rd Hospital of PLA, Shenyang, 110042 Liaoning Province, China.
authors: Ying
authors: Y
authors: Zi
authors: Laboratory of Severe and War-Related Trauma Center, General Hospital of Shenyang Military Area Command of PLA, Shenyang, 110016 Liaoning Province, China.
authors: Yun-En
authors: YE
authors: Liu
authors: Laboratory of Severe and War-Related Trauma Center, General Hospital of Shenyang Military Area Command of PLA, Shenyang, 110016 Liaoning Province, China.
authors: Yu-Biao
authors: YB
authors: Zhang
authors: Department of Orthopedics, General Hospital of Shenyang Military Area Command of Chinese PLA, Rescue Center of Severe Wound and Trauma of PLA, Shenyang, 110016 Liaoning Province, China. Electronic address: xiangliangbils@126.com.
authors: Liang-Bi
authors: LB
authors: Xiang
authors: Laboratory of Severe and War-Related Trauma Center, General Hospital of Shenyang Military Area Command of PLA, Shenyang, 110016 Liaoning Province, China.
authors: Ming-xiao
authors: MX
authors: Hou
mesh_terms: D000818:Animals; D027682:Cation Transport Proteins / Q000378:metabolism*; D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D008315:Malondialdehyde / Q000378:metabolism; D008550:Melatonin / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3 / Q000378:metabolism*; D048054:Mitogen-Activated Protein Kinase 7 / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000378:metabolism / Q000494:pharmacology*; D010766:Phosphorylation; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D013482:Superoxide Dismutase / Q000378:metabolism; D015854:Up-Regulation; D015032:Zinc / Q000378:metabolism
chemical_list: D027682:Cation Transport Proteins; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; C485744:Slc39a1 protein, mouse; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D048054:Mitogen-Activated Protein Kinase 7; D015032:Zinc; D008550:Melatonin
keywords: Apoptosis; ERK1/2; ERK5; Melatonin; N2a cells; Zip1