title: Cytokine levels in plasma and gingival crevicular fluid in chronic periodontitis.
abstract: OBJECTIVE
  To evaluate the Th1/Th2/Th17 cytokine levels in plasma and gingival crevicular fluid (GCF) from chronic periodontitis patients and healthy controls.
  
  
  METHODS
  The concentration of interleukin-2 (IL-2), IL-4, IL-6, IL-10, IL-17, TNF, and IFN-γ were determined using a flow cytometric multiplex immunoassay (CBA), and was compared between the periodontitis group and the healthy group. Spearman rho coefficient was used to correlate cytokines in GCF in the periodontitis group and the healthy group, respectively.
  
  
  RESULTS
  Comparisons of two groups of Th1/Th2/Th17 cytokine levels in plasma and GCF showed no statistically significant differences (P > 0.05), except Th17 (IL-17) level in plasma that was higher in the periodontitis group than the healthy group (P < 0.05). A stronger correlation between IL-17/IL-4 and IL-17/IL-10 was observed in periodontitis patients than in healthy controls.
authors: Xiao-Tao
authors: XT
authors: Chen
authors: Jing-Yi
authors: JY
authors: Tan
authors: Li-Hong
authors: LH
authors: Lei
authors: Li-Li
authors: LL
authors: Chen
mesh_terms: D000328:Adult; D055113:Chronic Periodontitis / Q000097:blood / Q000276:immunology*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis* / Q000097:blood; D016753:Interleukin-10 / Q000032:analysis / Q000097:blood; D020381:Interleukin-17 / Q000032:analysis / Q000097:blood; D007376:Interleukin-2 / Q000032:analysis / Q000097:blood; D015847:Interleukin-4 / Q000032:analysis / Q000097:blood; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood; D007378:Interleukins / Q000032:analysis* / Q000097:blood; D008297:Male; D008875:Middle Aged; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D048069:Tumor Necrosis Factors / Q000032:analysis* / Q000097:blood
chemical_list: C508609:IL10 protein, human; C508594:IL2 protein, human; C508598:IL4 protein, human; C508600:IL6 protein, human; D020381:Interleukin-17; D007376:Interleukin-2; D015850:Interleukin-6; D007378:Interleukins; D048069:Tumor Necrosis Factors; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma