title: Polymorphisms in the retinoic acid-1 like-receptor family of genes and their association with clinical outcome of dengue virus infection.
abstract: Polymorphisms in the DDX58 and IFIH1 genes, which code for the retinoic acid inducible gene-1 protein and myeloid differentiation factor (MDA) 5, were investigated in 120 dengue (DEN) cases (88 dengue fever [DF] cases and 32 dengue hemorrhagic fever [DHF] cases) and 109 healthy controls (HCs) to investigate their association with dengue. The results revealed a lower carrier frequency of the DDX58 rs3205166 G allele in DEN than in HCs and a higher frequency of the DDX58 rs669260 T/C genotype in DHF than in DF cases (P = 0.043, OR with 95 % CI 3.358 [1.038-10.861]). This suggests that polymorphisms in DDX58 gene influence the clinical outcome of DENV infection.
authors: Dengue Group, National Institute of Virology (Indian Council of Medical Research), 20A, Dr Ambedkar Road, Pune, Maharashtra, India, alagarasu@gmail.com.
authors: K
authors: K
authors: Alagarasu
authors: R S
authors: RS
authors: Memane
authors: P S
authors: PS
authors: Shah
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000235:genetics*; D003715:Dengue / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011971:Receptors, Immunologic; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D011971:Receptors, Immunologic; C452820:RIGI protein, human; C452815:IFIH1 protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1