title: Diffusion MRI abnormalities detection with orientation distribution functions: a multiple sclerosis longitudinal study.
abstract: We propose a new algorithm for the voxelwise analysis of orientation distribution functions between one image and a group of reference images. It relies on a generic framework for the comparison of diffusion probabilities on the sphere, sampled from the underlying models. We demonstrate that this method, combined to dimensionality reduction through a principal component analysis, allows for more robust detection of lesions on simulated data when compared to classical tensor-based analysis. We then demonstrate the efficiency of this pipeline on the longitudinal comparison of multiple sclerosis patients at an early stage of the disease: right after their first clinically isolated syndrome (CIS) and three months later. We demonstrate the predictive value of ODF-based scores for the early detection of lesions that will appear or heal.
authors: VISAGES: INSERM U746, CNRS UMR6074, INRIA, University of Rennes I, France. Electronic address: Olivier.Commowick@inria.fr.
authors: Olivier
authors: O
authors: Commowick
authors: Neurology Department, University Hospital of Reims, France.
authors: Adil
authors: A
authors: Maarouf
authors: VISAGES: INSERM U746, CNRS UMR6074, INRIA, University of Rennes I, France; Radiology Department, University Hospital of Rennes, 2 Rue Henri le Guilloux, 35000 Rennes, France.
authors: Jean-Christophe
authors: JC
authors: Ferré
authors: CRMBM-CNRS-Aix-Marseille University, 27 Bd. Jean Moulin, 1305 Marseille, France.
authors: Jean-Philippe
authors: JP
authors: Ranjeva
authors: VISAGES: INSERM U746, CNRS UMR6074, INRIA, University of Rennes I, France; Neurology Department, University Hospital of Rennes, 2 Rue Henri le Guilloux, 35000 Rennes, France.
authors: Gilles
authors: G
authors: Edan
authors: VISAGES: INSERM U746, CNRS UMR6074, INRIA, University of Rennes I, France.
authors: Christian
authors: C
authors: Barillot
mesh_terms: D000328:Adult; D000375:Aging / Q000473:pathology*; D000465:Algorithms; D001921:Brain / Q000473:pathology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008137:Longitudinal Studies; D008297:Male; D009103:Multiple Sclerosis / Q000473:pathology*; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D066127:White Matter / Q000473:pathology*
keywords: Diffusion MRI; Orientation distribution functions; Patient to controls comparison