title: Osteoporosis and bone fractures in alcoholic liver disease: a meta-analysis.
abstract: OBJECTIVE
  To evaluate the association between alcoholic liver disease (ALD) and bone fractures or osteoporosis.
  
  
  METHODS
  Non-randomized studies were identified from databases (PubMed, EMBASE, and the Cochrane Library). The search was conducted using Boolean operators and keywords, which included "alcoholic liver diseases", "osteoporosis", or "bone fractures". The prevalence of any fractures or osteoporosis, and bone mineral density (BMD) were extracted and analyzed using risk ratios and standardized mean difference (SMD). A random effects model was applied.
  
  
  RESULTS
  In total, 15 studies were identified and analyzed. Overall, ALD demonstrated a RR of 1.944 (95%CI: 1.354-2.791) for the development of bone fractures. However, ALD showed a RR of 0.849 (95%CI: 0.523-1.380) for the development of osteoporosis. BMD was not significantly different between the ALD and control groups, although there was a trend toward lower BMD in patients with ALD (SMD in femur-BMD: -0.172, 95%CI: -0.453-0.110; SMD in spine-BMD: -0.169, 95%CI: -0.476-0.138). Sensitivity analyses showed consistent results.
  
  
  CONCLUSIONS
  Current publications indicate significant associations between bone fractures and ALD, independent of BMD or the presence of osteoporosis.
authors: Chang Seok Bang, Sung Wha Lee, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
authors: Chang Seok
authors: CS
authors: Bang
authors: Chang Seok Bang, Sung Wha Lee, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
authors: In Soo
authors: IS
authors: Shin
authors: Chang Seok Bang, Sung Wha Lee, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
authors: Sung Wha
authors: SW
authors: Lee
authors: Chang Seok Bang, Sung Wha Lee, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
authors: Jin Bong
authors: JB
authors: Kim
authors: Chang Seok Bang, Sung Wha Lee, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
authors: Gwang Ho
authors: GH
authors: Baik
authors: Chang Seok Bang, Sung Wha Lee, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
authors: Ki Tae
authors: KT
authors: Suk
authors: Chang Seok Bang, Sung Wha Lee, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
authors: Jai Hoon
authors: JH
authors: Yoon
authors: Chang Seok Bang, Sung Wha Lee, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
authors: Yeon Soo
authors: YS
authors: Kim
authors: Chang Seok Bang, Sung Wha Lee, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
authors: Dong Joon
authors: DJ
authors: Kim
mesh_terms: D015519:Bone Density; D016009:Chi-Square Distribution; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis / Q000453:epidemiology*; D016017:Odds Ratio; D010024:Osteoporosis / Q000175:diagnosis / Q000453:epidemiology*; D058866:Osteoporotic Fractures / Q000175:diagnosis / Q000453:epidemiology*; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
keywords: Alcoholic liver diseases; Bone fractures; Osteoporosis