title: [Systematic genetic analysis for a case with duplication 9p].
abstract: OBJECTIVE
  To identify the genetic cause for a case with growth retardation and mental retardation.
  
  
  METHODS
  After conventional peripheral blood karyotyping with G-banding, the abnormal chromosome was identified as suspicious 9p duplication by multiplex ligation dependent probe amplification (MLPA) .
  
  
  RESULTS
  The proband's karyotype was suspicious 46,XY,der(9)t(9;14)(q13;q11.2), then the abnormal chromosome 9 was identified as 9p duplication with MLPA. The 9p duplication occurs because of a balanced chromosomal rearrangement between two chromosomes of 9 and 14 in the proband's father.
  
  
  CONCLUSIONS
  9p11.2-p24.3 duplication is the cause of abnormal phenotypes in the child patient. Cytogenetic methods combined with MLPA can efficiently identify abnormal chromosomes and provide accurate results for clinical diagnosis and treatment.
authors: Department of Gynaecology and Obstetrics, The Hospital Affiliated to Nantong University, Nantong, Jiangsu 226001, P.R.China. jsnt_zhangyuquan@yahoo.com.cn; hongliszivf@163.com.
authors: Jianlin
authors: J
authors: Zhang
authors: Haibo
authors: H
authors: Li
authors: Shenghua
authors: S
authors: Jiang
authors: Hong
authors: H
authors: Li
authors: Yuquan
authors: Y
authors: Zhang
mesh_terms: D002675:Child, Preschool; D002871:Chromosome Banding; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D006801:Humans; D008297:Male; D014314:Trisomy / Q000235:genetics*