title: MiR-506 suppresses tumor proliferation and invasion by targeting FOXQ1 in nasopharyngeal carcinoma.
abstract: MiRNAs are small noncoding RNAs that play important roles in various biological processes including tumorigenesis. However, little is known about the expression and function of miR-506 in nasopharyngeal carcinoma (NPC). In this study, we showed that miR-506 was downregulated in nasopharyngeal carcinoma (NPC) cell lines and tissues. Ectopic expression of miR-506 dramatically suppressed cell proliferation, colony formation and invasion. Moreover, we identified the Forkhead box Q1 (FOXQ1) gene as a novel direct target of miR-506. MiR-506 exerts its tumor suppressor function through inhibition of the FOXQ1, which was involved in tumor metastasis and proliferation in various cancers. Furthermore, the expression of FOXQ1 is up-regulated in NPC cell lines and tissues. Taken together, our results indicate that miR-506 functions as a tumor suppressor miRNA in NPC and that its suppressive effects are mediated chiefly by repressing FOXQ1 expression.
authors: Department of Human Anatomy, Hebei Medical University, Shijiazhuang, PR China.
authors: Zhanchi
authors: Z
authors: Zhang
authors: Department of Human Anatomy, Hebei Medical University, Shijiazhuang, PR China.
authors: Jun
authors: J
authors: Ma
authors: The Third Hospital of Hebei Medical University, Shijiazhuang, PR China.
authors: Guang
authors: G
authors: Luan
authors: Department of Human Anatomy, Hebei Medical University, Shijiazhuang, PR China.
authors: Lin
authors: L
authors: Kang
authors: Department of Human Anatomy, Hebei Medical University, Shijiazhuang, PR China.
authors: Yuhong
authors: Y
authors: Su
authors: Department of Otorhinolaryngology, The Third Hospital of Hebei Medical University, Shijiazhuang, PR China.
authors: Yanan
authors: Y
authors: He
authors: Department of Otorhinolaryngology, The Third Hospital of Hebei Medical University, Shijiazhuang, PR China.
authors: Feng
authors: F
authors: Luan
mesh_terms: D001483:Base Sequence; D002277:Carcinoma; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015194:Diffusion Chambers, Culture; D051858:Forkhead Transcription Factors / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D017930:Genes, Reporter; D006801:Humans; D008156:Luciferases / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
chemical_list: C484579:FOXQ1 protein, human; D051858:Forkhead Transcription Factors; C561508:MIRN506 microRNA, human; D035683:MicroRNAs; D008156:Luciferases