title: Alginate gel-coated oil-entrapped alginate-tamarind gum-magnesium stearate buoyant beads of risperidone.
abstract: A novel alginate gel-coated oil-entrapped calcium-alginate-tamarind gum (TG)-magnesium stearate (MS) composite floating beads was developed for intragastric risperidone delivery with a view to improving its oral bioavailability. The TG-blended alginate core beads containing olive oil and MS as low-density materials were accomplished by ionotropic gelation technique. Effects of polymer-blend ratio (sodium alginate:TG) and crosslinker (CaCl2) concentration on drug entrapment efficiency (DEE, %) and cumulative drug release after 8 h (Q8h, %) were studied to optimize the core beads by a 3(2) factorial design. The optimized beads (F-O) exhibited DEE of 75.19±0.75% and Q8h of 78.04±0.38% with minimum errors in prediction. The alginate gel-coated optimized beads displayed superior buoyancy and sustained drug release property. The drug release profiles of the drug-loaded uncoated and coated beads were best fitted in Higuchi kinetic model with Fickian and anomalous diffusion driven mechanisms, respectively. The optimized beads yielded a notable sustained drug release profile as compared to marketed immediate release preparation. The uncoated and coated Ca-alginate-TG-MS beads were also characterized by SEM, FTIR and P-XRD analyses. Thus, the newly developed alginate-gel coated oil-entrapped alginate-TG-MS composite beads are suitable for intragastric delivery of risperidone over a prolonged period of time.
authors: Department of Industrial Pharmacy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India. Electronic address: hriday.bera1@gmail.com.
authors: Hriday
authors: H
authors: Bera
authors: Department of Industrial Pharmacy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India.
authors: Shashank
authors: S
authors: Boddupalli
authors: Department of Industrial Pharmacy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India.
authors: Sridhar
authors: S
authors: Nandikonda
authors: Department of Industrial Pharmacy, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad 500090, India.
authors: Sanoj
authors: S
authors: Kumar
authors: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Odisha 757086, India.
authors: Amit Kumar
authors: AK
authors: Nayak
mesh_terms: D000464:Alginates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D065546:Drug Liberation; D005782:Gels / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D053149:Plant Gums / Q000737:chemistry*; D018967:Risperidone / Q000008:administration & dosage*; D017550:Spectroscopy, Fourier Transform Infrared; D013229:Stearic Acids / Q000737:chemistry*; D029861:Tamarindus / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D000464:Alginates; D005782:Gels; D006603:Hexuronic Acids; D053149:Plant Gums; D013229:Stearic Acids; C031183:stearic acid; D020723:Glucuronic Acid; D008274:Magnesium; D018967:Risperidone
keywords: Alginate; Emulsion gel beads; Tamarind gum