title: Mineral status of premature infants in early life and linear growth at age 3.
abstract: BACKGROUND
  Preterm infants are at significant risk of reduced bone mineral content and subsequent bone disease (metabolic bone disease of prematurity, MBDP). MBDP is frequently found in very low-birthweight (VLBW) infants, but long-term height prognosis is not well known.
  
  
  METHODS
  VLBW infants from two major neonatal intensive care units were studied. Medical records were reviewed. A total of 143 subjects were analyzed after excluding subjects who died, or who had severe complications that could affect linear growth, Silver-Russell syndrome, severe cholestasis, and/or chromosomal abnormality. The relationship between MBDP and height at age 3 was investigated.
  
  
  RESULTS
  Height standard deviation score (SDS) at age 3 negatively correlated with peak serum alkaline phosphatase (ALP) activity in early life (r = -0.30, P = 0.0003) and positively correlated with serum phosphorus (P) at peak ALP (r = 0.33, P = 0.0002). In addition, serum P independently affected height SDS at 3 years of age (β = 0.19, P = 0.018), and was significantly different between infants with and without catch-up growth in height (difference: 0.23 mmol/L, 95%CI: 0.09-0.36, P = 0.0010).
  
  
  CONCLUSIONS
  MBDP, particularly hypophosphatemia in the early period of life, is associated with linear growth until 3 years of age in VLBW infants.
authors: Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Bunkyo-ku.
authors: Tsuyoshi
authors: T
authors: Isojima
authors: Department of Neonatology, Tokyo Metropolitan Bokutoh Hospital, Sumida-ku, Tokyo, Japan.
authors: Reiko
authors: R
authors: Kushima
authors: Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Bunkyo-ku.
authors: Keiji
authors: K
authors: Goishi
authors: Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Bunkyo-ku.|Department of Neonatology, Tokyo Metropolitan Bokutoh Hospital, Sumida-ku, Tokyo, Japan.
authors: Shinya
authors: S
authors: Tsuchida
authors: Department of Neonatology, Tokyo Metropolitan Bokutoh Hospital, Sumida-ku, Tokyo, Japan.
authors: Toyoko
authors: T
authors: Watanabe
authors: Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Bunkyo-ku.
authors: Naoto
authors: N
authors: Takahashi
authors: Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Bunkyo-ku.
authors: Sachiko
authors: S
authors: Kitanaka
mesh_terms: D015519:Bone Density / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology* / Q000378:metabolism; D019102:Infant, Very Low Birth Weight; D008297:Male; D008903:Minerals / Q000378:metabolism*; D011379:Prognosis
chemical_list: D008903:Minerals
keywords: metabolic bone disease of prematurity; mineral supplementation; short stature; very low-birthweight infant