title: [Diagnosis and prenatal diagnosis to a family of hemoglobin variant with α-thalassemia].
abstract: OBJECTIVE
  Diagnosis and prenatal diagnosis to a family of hemoglobin variant with α-thalassemia.
  
  
  METHODS
  Whole blood cell analysis, hemoglobin analysis by capillary zone electrophoresis (CZE), Gap-PCR, polymerase chain reaction-reverse dot blot (PCR-RDB) assay and DNA sequencing.
  
  
  RESULTS
  Hb Zurich Albisrieden with α°-thalassemia lead to severe anemia. The genotype of fetus is also Hb Zurich Albisrieden with α°-thalassemia.
  
  
  CONCLUSIONS
  Abnormal hemoglobin with α-thalassemia may lead to severe anemia, Prenatal diagnosis of thalassemia has the vital significance for eugenic birth.
authors: Medical Genetics Center, Key Laboratory of Metabolic and Genetic Disease in Women and Children, Guangdong Women and Children Hospital, Guangzhou, Guangdong 510010, P.R. China. yinaihua@vip.126.com.
authors: Li
authors: L
authors: Du
authors: Jing
authors: J
authors: Wu
authors: Danqing
authors: D
authors: Qin
authors: Jicheng
authors: J
authors: Wang
authors: Mingyong
authors: M
authors: Luo
authors: Hao
authors: H
authors: Guo
authors: Tenglong
authors: T
authors: Yuan
authors: Yanxia
authors: Y
authors: Zhang
authors: Yixia
authors: Y
authors: Wang
authors: Aihua
authors: A
authors: Yin
mesh_terms: D000328:Adult; D001483:Base Sequence; D002675:Child, Preschool; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011247:Pregnancy; D011296:Prenatal Diagnosis; D055815:Young Adult; D017085:alpha-Thalassemia / Q000097:blood / Q000175:diagnosis / Q000196:embryology / Q000235:genetics*
chemical_list: D006455:Hemoglobins, Abnormal; C500302:hemoglobin Zurich Albisrieden