title: Is there association between TLR9 polymorphism and SLE susceptibility?
abstract: After reading the article "Susceptibility to SLE in South Indian Tamils may be influenced by genetic selection pressure on TLR2 and TLR9 genes", we have some doubt. As the differences existed in genetic risk factors, SLE symptoms, and disease severity between the childhood-onset and adult-onset SLE patients, the association analyses in study population including both childhood-onset and adult-onset SLE patients might be inappropriate. Besides, in order to explore whether TLR9 (-1237C/T) polymorphism impact SLE occurrence, we reviewed current studies and conducted a meta-analysis. The results of meta-analysis showed no significant correlation between TLR9 (-1237C/T) and SLE susceptibility in total population (allele model OR=0.97, 95%CI (0.81-1.14)), or in Caucasians (allele model OR=1.05, 95%CI (0.72-1.39)) and in Asians (allele model OR=0.94, 95%CI (0.54-1.35)). Therefore, confirmative evidence reveals that TLR9 (-1237C/T) polymorphism does not correlate with SLE susceptibility.
authors: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Qian
authors: Q
authors: Xi
authors: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Yun
authors: Y
authors: Liao
authors: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Yongkang
authors: Y
authors: Wu
authors: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: wanglanlanhxvip@163.com.
authors: Lanlan
authors: L
authors: Wang
mesh_terms: D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D012641:Selection, Genetic; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D051217:Toll-Like Receptor 9 / Q000235:genetics*
chemical_list: D051195:Toll-Like Receptor 2; D051217:Toll-Like Receptor 9
keywords: Genetic polymorphism; SNP; Systemic lupus erythematosus; Toll-like receptor 9