title: [The antibodies to neurohormonal anti-genes as a criterion of early diagnostic and neurointoxication in workers of chemical enterprises].
abstract: The examination was applied to enterprise workers laboring in conditions of vinyl chloride (79 patients), caustic soda (24 patients) and 10 patients with professional chronic mercury intoxication. The differences are established concerning manifestation of autoimmune reactions of personnel working in conditions of chronic effecting of vinyl chloride distinct of parameters characterizing autoimmune reactions of personnel working under impact of another neuro-toxicants (vapors of metallic mercury). The increasing of auto-antibodies to MAG was detected in healthy personnel and increasing of concentrations of auto-antibodies to protein S-100 and DNA was detected in personnel with initial manifestations of neuro-intoxication. These occurrences testify availability, of different mechanisms underlying formation of neurological disorders. The study data confirms involvement of auto-antibodies to neuronal antigens into derangement of neural activity in personnel working in conditions of effect of vinyl chloride and vapors of metallic mercury. Hence, the new possibilities are opened in studying pathogenesis of occupational neuro-intoxications. The detection of auto-antibodies to proteins of neural tissue can be recommended as a criterion of early identification of damage of neural system in personnel working in conditions of chemical industry.
authors: G M
authors: GM
authors: Bodienkova
authors: R Iu
authors: RIu
authors: Alekseev
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000302:isolation & purification*; D001798:Blood Proteins / Q000276:immunology / Q000302:isolation & purification*; D002617:Chemical Industry; D042241:Early Diagnosis; D006801:Humans; D008297:Male; D008628:Mercury / Q000633:toxicity; D008875:Middle Aged; D009474:Neurons / Q000187:drug effects / Q000473:pathology; D009784:Occupational Diseases / Q000097:blood* / Q000139:chemically induced / Q000473:pathology; D016273:Occupational Exposure; D009418:S100 Proteins / Q000276:immunology / Q000302:isolation & purification*; D012972:Sodium Hydroxide / Q000633:toxicity; D014752:Vinyl Chloride / Q000633:toxicity
chemical_list: D001323:Autoantibodies; D001798:Blood Proteins; D009418:S100 Proteins; D012972:Sodium Hydroxide; D008628:Mercury; D014752:Vinyl Chloride