title: Is iron-deficiency anemia associated with migraine? Is there a role for anxiety and depression?
abstract: BACKGROUND
  In this study, we determined the frequency of migraine headache in iron-deficiency anemia (IDA) patients and whether it was related to anxiety, depression, and somatization.
  
  
  METHODS
  We included 127 consecutive IDA patients into the study. All patients were asked validated questions about headache and migraine face-to-face. They were administered validated questionnaires for anxiety-depression The Hospital Anxiety and Depression Scale and somatization. The quality of life (QoL) disturbance associated with headache was marked on a 0-10 VAS.
  
  
  RESULTS
  Of all IDA patients, 79.5 % defined headache at any time of their life. In addition, 36.2 % of all IDA patients defined the criteria for migraine. IDA patients with migraine were more frequently smokers and had significantly lower hemoglobin and mean corpuscular volume values (p values < 0.05). The IDA group with migraine had significantly higher mean anxiety score (p = 0.046) and headache-related QoL disturbance score (p = 0.021) than the IDA group without migraine. Migraine patients with aura had lower hemoglobin values (p = 0.02), higher depression scores (p = 0.005), and higher migraine-related QoL disturbance scores than others.
  
  
  CONCLUSIONS
  IDA patients have a high frequency of migraine headache. The presence of anxiety and depression have great influence on the presence of migraine in IDA patients.
authors: Department of Hematology, Trakya University Medical Faculty, Eski Yildiz Cad. Park Apt. No:22 Daire:18, Beşiktaş, Istanbul/Edirne, Turkey. gepamuk@yahoo.com.
authors: Gülsüm Emel
authors: GE
authors: Pamuk
authors: Department of Psychiatry, Edirne State Hospital, Edirne, Turkey.
authors: Mehmet Şerif
authors: MŞ
authors: Top
authors: Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey.
authors: Mehmet Şevki
authors: MŞ
authors: Uyanık
authors: Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey.
authors: Hilal
authors: H
authors: Köker
authors: Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey.
authors: Mustafa
authors: M
authors: Akker
authors: Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey.
authors: Recep
authors: R
authors: Ak
authors: Department of Internal Medicine, Sema Hospital, İstanbul, Turkey.
authors: Ömer Atalay
authors: ÖA
authors: Yürekli
authors: Department of Neurology, Trakya University Medical Faculty, Edirne, Turkey.
authors: Yahya
authors: Y
authors: Çelik
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D018798:Anemia, Iron-Deficiency / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D001007:Anxiety / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D015984:Causality; D015897:Comorbidity; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D012307:Risk Factors; D013001:Somatoform Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D014421:Turkey / Q000453:epidemiology; D016387:Women's Health / Q000706:statistics & numerical data*; D055815:Young Adult
keywords: Anxiety; Depression; Headache; Iron-deficiency anemia; Migraine