title: The benefit of sirolimus maintenance immunosuppression and rabbit antithymocyte globulin induction in liver transplant recipients that develop acute kidney injury in the early postoperative period.
abstract: Published data are limited describing renal outcomes in orthotopic liver transplant (OLT) recipients prescribed sirolimus (SRL) maintenance immunosuppression (MIS) and rabbit antithymocyte globulin (rATG) induction. We investigated whether SRL MIS and rATG induction facilitated recovery of acute kidney injury in the early postoperative period. This retrospective descriptive study screened 308 consecutive OLTs performed between 2006 and 2009. All patients received rATG induction with steroid avoidance. MIS consisted of SRL or TAC with mycophenolate mofetil. A total of 197 patients were included: 168 (85%) received TAC and 29 (15%) received SRL for a median of 365 days. Demographics were similar between groups except for a higher incidence of pretransplant renal dysfunction in the SRL recipients (SRL 59% versus TAC 21%; P < 0.05). The eGFR was significantly (P < 0.05) higher for all time points in the TAC group with the exception of month 2. However, improvement in eGFR was significantly (P < 0.05) greater in the SRL group postoperatively. Our study suggests that rATG induction and SRL maintenance immunosuppression facilitate renal recovery for liver transplant recipients that develop acute kidney injury in the early postoperative period.
authors: University of Tennessee College of Pharmacy, Memphis, TN 38163, USA ; Methodist University Hospital Transplant Institute, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
authors: Benjamin T
authors: BT
authors: Duhart
authors: University of Virginia Medical Center, Charlottesville, VA 22908, USA.
authors: Winston A
authors: WA
authors: Ally
authors: University of Tennessee College of Pharmacy, Memphis, TN 38163, USA ; Methodist University Hospital Transplant Institute, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
authors: Amy G
authors: AG
authors: Krauss
authors: University of Tennessee College of Pharmacy, Memphis, TN 38163, USA.
authors: Joanna Q
authors: JQ
authors: Hudson
authors: Methodist University Hospital Transplant Institute, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
authors: James D
authors: JD
authors: Eason
authors: Methodist University Hospital Transplant Institute, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
authors: Vinaya
authors: V
authors: Rao
authors: Methodist University Hospital Transplant Institute, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
authors: Jason M
authors: JM
authors: Vanatta