title: Adult vascular wall resident multipotent vascular stem cells, matrix metalloproteinases, and arterial aneurysms.
abstract: Evidences have shown the presence of multipotent stem cells (SCs) at sites of arterial aneurysms: they can differentiate into smooth muscle cells (SMCs) and are activated after residing in a quiescent state in the vascular wall. Recent studies have implicated the role of matrix metalloproteinases in the pathogenesis of arterial aneurysms: in fact the increased synthesis of MMPs by arterial SMCs is thought to be a pivotal mechanism in aneurysm formation. The factors and signaling pathways involved in regulating wall resident SC recruitment, survival, proliferation, growth factor production, and differentiation may be also related to selective expression of different MMPs. This review explores the relationship between adult vascular wall resident multipotent vascular SCs, MMPs, and arterial aneurysms.
authors: Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Magna Graecia University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy.
authors: Bruno
authors: B
authors: Amato
authors: Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Magna Graecia University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy.
authors: Rita
authors: R
authors: Compagna
authors: Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80100 Naples, Italy.
authors: Maurizio
authors: M
authors: Amato
authors: Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy.
authors: Raffaele
authors: R
authors: Grande
authors: Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy.
authors: Lucia
authors: L
authors: Butrico
authors: Department of Medicine and Health Sciences, University of Molise, 88100 Campobasso, Italy.
authors: Alessio
authors: A
authors: Rossi
authors: Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy.
authors: Agostino
authors: A
authors: Naso
authors: Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy.
authors: Michele
authors: M
authors: Ruggiero
authors: Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Magna Graecia University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy.
authors: Stefano
authors: S
authors: de Franciscis
authors: Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Magna Graecia University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy ; Department of Medical and Surgical Sciences, University of Catanzaro, 88100 Catanzaro, Italy.
authors: Raffaele
authors: 0000-0003-4477-7412
authors: R
authors: Serra