title: Pre-emptive effect of dexamethasone injection and consumption on post-operative swelling, pain, and trismus after third molar surgery. A prospective, double blind and randomized study.
abstract: OBJECTIVE
  To evaluate the preventative effect of intravenous 4 mg of dexamethasone and 8 mg oral dexamethasone on post-operative pain, swelling and trismus after the surgical extraction of mandibular third molars.
  
  
  METHODS
  A randomized clinical trial comprised of 200 patients (control group I intravenous and experimental group II orally) with impacted lower third molars, average age 20.8 years with no local or systemic problems, with bilateral impacted lower third molars, were operated under local anesthesia. Group I was given 4 mg IV and group II was given 8 mg orally of dexamethasone 1 h before procedure. The choice of which side to operate first and the amount of concentration of medication to use was made randomly and double-blindly. Post-operative pain was evaluated using a visual analog scale (VAS) and the degree of swelling was evaluated through facial reference points' variation. The presence of trismus was analyzed through measurement of the interincisal distance (IID). These assessments were obtained before the operation and 24 h, 48 h and 7th POD.
  
  
  RESULTS
  No significant difference was found in facial swelling and trismus between IV 4 mg injection and oral 8 mg consumption after lower third molar surgery (student t test P > 0.05). The visual analogue scale scores for pain assessment showed no significant difference between IV injection and oral route of dexamethasone (student t test P > 0.05).
  
  
  CONCLUSIONS
  Patients can be administered 8 mg oral dexamethasone is as effective as 4 mg intra venous route without much difference in final outcome at any given point of time.
authors: Professor, Department of Conservative and Endodontics, Bhartiya Vidyapeeth Dental College, Pune, Maharashtra, India.
authors: Pradeep D
authors: PD
authors: Chaudhary
authors: Reader, Department of Oral and Maxillofacial Surgery, Institute of Dental Science - Bareilly, Uttar Pradesh, India.
authors: Sanjay
authors: S
authors: Rastogi
authors: Reader, Department of Oral and Maxillofacial Surgery, Private Practice, Uttar Pradesh, India.
authors: Prashant
authors: P
authors: Gupta
authors: Reader, Department of Oral and Maxillofacial Surgery, Institute of Dental Science - Bareilly, Uttar Pradesh, India.
authors: B
authors: B
authors: Niranjanaprasad Indra
authors: Professor and Consultant, Oral and Maxillofacial Surgery, Private Practice, Kerala, India.
authors: Roy
authors: R
authors: Thomas
authors: Post Graduate Student, Department of Oral and Maxillofacial Surgery, ITS - Centre for Dental Studies and Research, Murad Nagar, Ghaziabad, Uttar Pradesh, India.
authors: Rupshikha
authors: R
authors: Choudhury
keywords: Dexamethasone; Impacted mandibular third molar; Pain; Swelling; Trismus