title: [Influence of physico-chemical properties of materials on the postcompressional parameters of tablets].
abstract: The number of tablets marketed with a score line to aid divisibility is increasing. The subdivision of scored tablets in order to ensure dose flexibility may be an easier and cheaper solution from the aspect of production. However, to ensure the appropriate mechanical properties and divisibility of tablets so as to guarantee consequent dosing is a difficult problem, which is influenced by many properties of the applied materials, such as the physicochemical behaviour, the plasticity, the degree of elasticity, the mechanism of compression, etc. These exert a significant influence on the postcompressional properties of tablets, and hence on the subdivision of tablets. Despite the considerable difficulties, the increasing importance in paediatrics and the ever stricter requirements of the drug authorities, the subdivision of scored tablets is a poorly studied field. This paper deals with the influence of physico-chemical properties of materials on the postcompressional parameters of tablets, and especially on the subdivision of tablets. For measurement of the force required to break tablets into halves, a laboratory-constructed hardness tester was utilized.
authors: Tamás
authors: T
authors: Sovány
authors: Klára
authors: K
authors: Hódi
mesh_terms: D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D004334:Drug Administration Schedule; D004339:Drug Compounding; D004867:Equipment Design; D018737:Hand Strength; D006244:Hardness; D006245:Hardness Tests / Q000295:instrumentation*; D006801:Humans; D011312:Pressure; D013607:Tablets / Q000737:chemistry*
chemical_list: D013607:Tablets