title: Nonarteritic anterior ischemic optic neuropathy in young patients.
abstract: OBJECTIVE
  To determine and report the demographic and clinical features of patients younger than 50 years with nonarteritic anterior ischemic optic neuropathy (NAION).
  
  
  METHODS
  In this comparative study, we retrospectively reviewed the medical records of 120 patients with NAION. Patients were divided into two groups according to their age; in group I, 44 patients were younger than 50 years, and in group II, 76 patients were older than 50 years.
  
  
  RESULTS
  The gender distribution was similar in both main groups. Involvement was bilateral in 50% and 26.3% of patients, respectively (P<0.0001). Diabetes mellitus was present in 63.6% of patients in group I and 47.3% of patients in group II (P=0.009). We found hypertension as a frequent risk factor in group II (P=0.019). There was no significant difference in the initial and final visual acuities of patients between the two groups. Both groups had a significantly thinner peripapillary nerve fiber layer (RNFL) in every quadrant. The relative loss was greatest in the superior quadrant in both groups. We generally observed inferior altitudinal defect and superior RNFL thinning in two groups. In group I, 30 eyes (68.1%) demonstrated angiographically diffuse optic disc filling delay of ≥5seconds after choroidal filling confirming ischemia, and 14 (31.8%) eyes with segmental optic disc filling delay. In group II, diffuse optic disc filling delay was seen in 56 of 76 (73.6%) eyes. Segmental optic disc filling delay was present in 20 eyes (26.3%). There was no significant difference in angiographic findings between the two groups (P=0.67).
  
  
  CONCLUSIONS
  We observed that age did not play a significant role in prognosis of NAION. Diabetes is an increased risk for NAION in the young age group, and HT for NAION in the older group. Fellow eye involvement is more frequent in young patients. These patients should be followed closely.
authors: Akdeniz university, faculty of medicine, department of ophthalmology, Antalya, Turkey. Electronic address: drelifbetul@yahoo.com.
authors: E B
authors: EB
authors: Turkoglu
authors: Akdeniz university, faculty of medicine, department of ophthalmology, Antalya, Turkey.
authors: H D
authors: HD
authors: Ilhan
authors: Akdeniz university, faculty of medicine, department of ophthalmology, Antalya, Turkey.
authors: A
authors: A
authors: Cetinkaya
authors: Akdeniz university, faculty of medicine, department of ophthalmology, Antalya, Turkey.
authors: A B
authors: AB
authors: Bilgin
authors: Akdeniz university, faculty of medicine, department of ophthalmology, Antalya, Turkey.
authors: K C
authors: KC
authors: Apaydin
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis*; D012189:Retrospective Studies
keywords: Eye; Jeune; Nerf optique; Neuropathie; Neuropathy; Optic nerve; Young; Œil