title: Upregulation of salivary α2 macroglobulin in patients with type 2 diabetes mellitus.
abstract: We investigated the expression of salivary α2-macroglobulin (α2-MG) in patients with type 2 diabetes mellitus (T2DM) to investigate its value for predicting damage to the salivary glands. A total of 116 patients with T2DM and 60 patients with impaired fasting glucose (IFG) were included in this study. Sixty health volunteers were enrolled as a control group. Unstimulated saliva was collected at 8 a.m. prior to breakfast. Expression of α2-MG was determined using an enzyme-linked immunosorbent assay. The correlation between salivary α2-MG, serum α2-MG, and concentration of fasting glucose was analyzed using Pearson correlation analysis. No significant difference was observed in the expression of serum α2-MG in the T2DM group, IFG group, and control group (P > 0.05). Compared with the control group and IFG group, a statistical difference was observed in the salivary α2-MG in the T2DM group (P < 0.01). No statistical difference was observed in the salivary α2-MG in the IFG group compared with the control group (P > 0.05). In the patients with T2DM, a close correlation was identified in the expression of serum α2-MG and salivary α2-MG (r = 0.52, P < 0.01). A poor correlation was identified between salivary α2-MG and blood sugar level (r = -0.12, P = 0.199). The expression of salivary α2-MG showed a remarkable increase in T2DM patients, which may be associated with functional disorders of the salivary gland.
authors: Center of Laboratory Medicine, The Affiliated Yuhuangding Hospital of Qingdao University Medical College, Yantai, China.
authors: J K
authors: JK
authors: Feng
authors: Center of Laboratory Medicine, The Affiliated Yuhuangding Hospital of Qingdao University Medical College, Yantai, China.
authors: Y F
authors: YF
authors: Lu
authors: Center of Laboratory Medicine, The Affiliated Yuhuangding Hospital of Qingdao University Medical College, Yantai, China fengtao7668@163.com.
authors: J
authors: J
authors: Li
authors: Center of Laboratory Medicine, The Affiliated Yuhuangding Hospital of Qingdao University Medical College, Yantai, China.
authors: Y H
authors: YH
authors: Qi
authors: Center of Laboratory Medicine, The Affiliated Yuhuangding Hospital of Qingdao University Medical College, Yantai, China.
authors: M L
authors: ML
authors: Yi
authors: Center of Laboratory Medicine, The Affiliated Yuhuangding Hospital of Qingdao University Medical College, Yantai, China.
authors: D Y
authors: DY
authors: Ma
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000378:metabolism*; D015854:Up-Regulation; D000511:alpha-Macroglobulins / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D000511:alpha-Macroglobulins