title: Development and Application of α-Heteroatom Ketones in Asymmetric Michael Reaction with β-trans-Nitroalkenes.
abstract: The successful design and application of a new type of N-phenyl-imidazole-modified α-heteroatom ketones in asymmetric anti-selective Michael reactions with β-trans-nitroalkenes is reported. High yields and enantioselectivities could be obtained, and the corresponding conjugate adducts could be further transformed into related chiral esters and cyclopropane derivatives with excellent enantioselectivities.
authors: †Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, People's Republic of China.|§Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
authors: Dongxu
authors: D
authors: Yang
authors: †Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors: Dan
authors: D
authors: Li
authors: †Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors: Linqing
authors: L
authors: Wang
authors: ‡State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China.
authors: Depeng
authors: D
authors: Zhao
authors: †Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou 730000, People's Republic of China.|§Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
authors: Rui
authors: R
authors: Wang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D007659:Ketones; D009574:Nitro Compounds