title: Twin screw wet granulation: Binder delivery.
abstract: The effects of three ways of binder delivery into the twin screw granulator (TSG) on the residence time, torque, properties of granules (size, shape, strength) and binder distribution were studied. The binder distribution was visualised through the transparent barrel using high speed imaging as well as quantified using offline technique. Furthermore, the effect of binder delivery and the change of screw configuration (conveying elements only and conveying elements with kneading elements) on the surface velocity of granules across the screw channel were investigated using particle image velocimetry (PIV). The binder was delivered in three ways; all solid binder incorporated with powder mixture, 50% of solid binder mixed with powder mixture and 50% mixed with water, all the solid binder dissolved in water. Incorporation of all solid binder with powder mixture resulted in the relatively longer residence time and higher torque, narrower granule size distribution, more spherical granules, weaker big-sized granules, stronger small-sized granules and better binder distribution compared to that in other two ways. The surface velocity of granules showed variation from one screw to another as a result of uneven liquid distribution as well as shown a reduction while introducing the kneading elements into the screw configuration.
authors: Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK. Electronic address: msaleh1@sheffield.ac.uk.
authors: Mohammed F
authors: MF
authors: Saleh
authors: Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
authors: Ranjit M
authors: RM
authors: Dhenge
authors: GSK, Third Avenue, Harlow, Essex CM19 5AW, UK.
authors: James J
authors: JJ
authors: Cartwright
authors: Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
authors: Michael J
authors: MJ
authors: Hounslow
authors: Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
authors: Agba D
authors: AD
authors: Salman
mesh_terms: D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding / Q000295:instrumentation* / Q000379:methods*; D005079:Excipients / Q000737:chemistry*; D007785:Lactose; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011208:Powders; D013499:Surface Properties; D014867:Water
chemical_list: D005079:Excipients; D011208:Powders; D014867:Water; D007785:Lactose
keywords: Granule properties; Online binder distribution; PIV; Twin screw; Wet granulation