title: Wilms' tumor 1 (WT1) protein expression in human developing tissues.
abstract: Several genes playing crucial roles in human development often reproduce a key role also during the onset and progression of malignant tumors. WT1, a transcription factor expressed with a dynamic pattern during human development, has either oncogenic or suppressor tumor properties. A detailed analysis of the immunohistochemical profile of WT1 protein in human developmental tissues could be exploitable as the rational for better understanding its role in cancerogenesis and planning innovative WT1-based therapeutic approaches. This review focuses on the dynamic immunohistochemical expression and distribution of WT1 protein during human ontogenesis, providing illustrations and discussion on the most relevant findings. The possibility that WT1 nuclear/cytoplasmic expression in some tumors mirrors its normal developmental regulation will be emphasized.
authors: Department of Biomedical and Biotechnological Sciences, Physiology Section, School of Medicine, University of Catania, Catania, Italy. Electronic address: parenti@unict.it.
authors: Rosalba
authors: R
authors: Parenti
authors: Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, University of Catania, Catania, Italy.
authors: Lucia
authors: L
authors: Salvatorelli
authors: Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Catania, Italy.
authors: Giuseppe
authors: G
authors: Musumeci
authors: Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Catania, Italy.
authors: Carmela
authors: C
authors: Parenti
authors: Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, University of Catania, Catania, Italy.
authors: Alexandra
authors: A
authors: Giorlandino
authors: Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, University of Catania, Catania, Italy.
authors: Fabio
authors: F
authors: Motta
authors: Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, University of Catania, Catania, Italy.
authors: Gaetano
authors: G
authors: Magro
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D003593:Cytoplasm / Q000378:metabolism* / Q000473:pathology; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D025721:WT1 Proteins / Q000096:biosynthesis*
chemical_list: D025721:WT1 Proteins; C583751:WT1 protein, human
keywords: Development; Human; Immunohistochemistry; Oncofetal; WT1