title: TGF-β signalling prevents pancreatic beta cell death after proliferation.
abstract: OBJECTIVE
  Maintenance of functional beta cell mass is critical for prevention of diabetes. The transforming growth factor-beta (TGF-β) receptor signalling pathway plays an essential role in pancreatic development. However, its involvement in control of post-natal beta cell growth has only been recently reported.
  
  
  METHODS
  Here, we studied the role of TGF-β receptor signalling in beta cell proliferation after 50% partial pancreatectomy (PPx), using beta cell-specific TGF-β receptor II (TBR2)-mutated mice.
  
  
  RESULTS
  Consistent with previous reports, we found that inhibition of TGF-β receptor signalling in beta cells resulted in slightly higher beta cell mass 1 week after PPx, due to greater beta cell proliferation. However, beta cell mass in these beta cell-specific TBR2-mutated mice significantly decreased by 12 weeks after PPx, resulting from increase in beta cell apoptosis.
  
  
  CONCLUSIONS
  Our data thus suggest that TGF-β receptor signalling may be required for prevention of beta cell death after proliferation, and highlight this pathway as an essential regulator during post-natal beta cell homoeostasis.
authors: Xi'an Jiaotong University Medical School, Department of Physiology, Xian, 710061, China; Department of Endocrinology, The General Hospital of Ningxia Medical University, Yinchuan, 750004, China.
authors: Chen
authors: C
authors: Lei
authors: Xiaoling
authors: X
authors: Zhou
authors: Yi
authors: Y
authors: Pang
authors: Yuanyuan
authors: Y
authors: Mao
authors: Xixuan
authors: X
authors: Lu
authors: Meijuan
authors: M
authors: Li
authors: Jie
authors: J
authors: Zhang
mesh_terms: D000818:Animals; D017209:Apoptosis; D002452:Cell Count; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D010180:Pancreatectomy; D012038:Regeneration; D015398:Signal Transduction / Q000235:genetics*; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*
chemical_list: C491198:Eomes protein, mouse; D020825:T-Box Domain Proteins; D016212:Transforming Growth Factor beta