title: Mechanistic modelling of radiation-induced bystander effects.
abstract: A model of radiation-induced bystander effects is presented that explicitly takes into account the transient nature of bystander signal emission post-irradiation, signal lifetime and the non-linear cellular response to the signals. Data are analysed on mutagenesis induced in human lymphoblasts in medium transfer experiments, in which the signal build-up time, medium dilution and the duration of reporter cells' exposure to the medium were varied. The model implies that the cellular release of bystander signals decreases rather slowly, with a characteristic time of about a day, whereas the signal itself decays with a lifetime of about an hour.
authors: Institute of Radiation Protection, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany pavel.kundrat@helmholtz-muenchen.de.
authors: P
authors: P
authors: Kundrát
authors: Institute of Radiation Protection, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors: W
authors: W
authors: Friedland
mesh_terms: D024201:Bystander Effect / Q000528:radiation effects*; D002478:Cells, Cultured; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology* / Q000528:radiation effects*; D008962:Models, Theoretical; D016296:Mutagenesis / Q000528:radiation effects*; D000069079:Radiation Exposure / Q000009:adverse effects*