title: Comparative study of the efficacy of topical steroid and antibiotic combination therapy versus oral antibiotic alone when treating acute rhinosinusitis.
abstract: BACKGROUND
  Acute rhinosinusitis arises as a consequence of viral rhinitis, and bacterial infection can subsequently occur. Intranasal antibiotics as an adjunct to corticosteroids usually demonstrate the greatest symptom relief.
  
  
  OBJECTIVE
  We wanted to clinically evaluate the effects of a topical antibiotic and steroid combination administered intranasally, versus an oral antibiotic alone when treating acute rhinosinusitis.
  
  
  METHODS
  Forty patients with acute bacterial rhinosinusitis were divided into two groups. Group A received an antibiotic and steroid combination (ofloxacin 0.26 per cent and dexamethasone 0.053 per cent nasal drops) for 10 days, administered intranasally (5 drops in each nostril/8 hours). Group B, the control group, received an oral antibiotic alone (amoxicillin 90 mg/kg).
  
  
  RESULTS
  Eight hours after commencing treatment, facial pain was more severe in group B and nasal obstruction was reduced in both groups. Ten days after commencing treatment, anterior nasal discharge was 0.15 per cent in group A and absent in group B.
  
  
  CONCLUSIONS
  The application of a topical antibiotic and steroid combination into the nasal cavity is an effective way of treating uncomplicated, acute bacterial rhinosinusitis with the theoretical advantages of easy administration, high local drug concentration and minimal systemic adverse effects.
authors: Otolaryngology Unit,Faculty of Medicine,Suez Canal University,Ismailia,Egypt.
authors: D M
authors: DM
authors: El-Hennawi
authors: Otolaryngology Unit,Faculty of Medicine,Suez Canal University,Ismailia,Egypt.
authors: M R
authors: MR
authors: Ahmed
authors: Otolaryngology Unit,Faculty of Medicine,Suez Canal University,Ismailia,Egypt.
authors: A M
authors: AM
authors: Farid
authors: Otolaryngology Unit,Faculty of Medicine,Suez Canal University,Ismailia,Egypt.
authors: A M
authors: AM
authors: Al Murtadah
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage*; D012220:Rhinitis / Q000188:drug therapy*; D012852:Sinusitis / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005938:Glucocorticoids; D003907:Dexamethasone; D000658:Amoxicillin; D015242:Ofloxacin
keywords: Absorption; Administration; Anti-Bacterial Agents; Bacterial Infections; Intranasal; Physiological; Randomized Controlled Trial; Rhinitis; Sinusitis; Steroids