title: Use of CSF α-synuclein in the differential diagnosis between Alzheimer's disease and other neurodegenerative disorders.
abstract: BACKGROUND
  The etiology and pathogenesis of neurodegenerative disorders has yet to be elucidated, so their differential diagnosis is a challenge. This is especially true in differentiating Alzheimer's disease (AD), dementia with Lewy bodies (DLB), Parkinson disease (PD), and multiple system atrophy (MSA).
  
  
  METHODS
  A total of 11 eligible articles were identified by search of electronic databases including PubMed, Springer Link, Elsevier, and the Cochrane Library, up to June 2014. In meta-analyses, standardized mean differences (SMD), with 95% confidence intervals (CI), comparing cerebrospinal fluid (CSF) measures of α-synuclein between the above conditions were calculated using random-effects models.
  
  
  RESULTS
  CSF α-synuclein concentrations were significantly higher in AD compared to DLB [SMD: 0.32, 95% CI: (0.02, 0.62), z = 2.07, P = 0.038]; PD [SMD: 0.87, 95% CI: (0.15, 1.58), z = 2.38, P = 0.017]; or MSA [SMD: 1.14, 95% CI: (0.15, 2.14), z = 2.25, P = 0.025]. However, no significant difference was found between patients with AD and neurological cognitively normal controls [SMD: 0.02, 95% CI: (-0.21, 0.24), z = 0.13, P = 0.894].
  
  
  CONCLUSIONS
  Results of these meta-analysis suggest that quantification of CSF α-synuclein could help distinguish AD from other neurodegenerative disorders such as DLB, PD, or MSA.
authors: Department of Nutrition and Food Hygiene,School of Public Health,Anhui Medical University,No. 81 Meishan Road,Hefei,Anhui 230032,China.
authors: Zheng-Yu
authors: ZY
authors: Wang
authors: Department of Nutrition and Food Hygiene,School of Public Health,Anhui Medical University,No. 81 Meishan Road,Hefei,Anhui 230032,China.
authors: Zhen-Min
authors: ZM
authors: Han
authors: Department of Nutrition and Food Hygiene,School of Public Health,Anhui Medical University,No. 81 Meishan Road,Hefei,Anhui 230032,China.
authors: Qi-Fei
authors: QF
authors: Liu
authors: Department of Clinical Laboratory Medicine,School of Public Health,Anhui Medical University,No. 81 Meishan Road,Hefei,Anhui 230032,China.
authors: Wei
authors: W
authors: Tang
authors: Department of Nutrition and Food Hygiene,School of Public Health,Anhui Medical University,No. 81 Meishan Road,Hefei,Anhui 230032,China.
authors: Kui
authors: K
authors: Ye
authors: Department of Clinical Laboratory Medicine,School of Public Health,Anhui Medical University,No. 81 Meishan Road,Hefei,Anhui 230032,China.
authors: Yu-You
authors: YY
authors: Yao
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D020961:Lewy Body Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D019578:Multiple System Atrophy / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D051844:alpha-Synuclein / Q000134:cerebrospinal fluid*
chemical_list: D051844:alpha-Synuclein
keywords: Alzheimer’s disease; Parkinson disease; dementia with Lewy bodies; meta-analysis; multiple system atrophy; α-synuclein