title: Toward a Comprehensive Model of Frailty: An Emerging Concept From the Hong Kong Centenarian Study.
abstract: OBJECTIVE
  A better understanding of the essential components of frailty is important for future developments of management strategies. We aimed to assess the incremental validity of a Comprehensive Model of Frailty (CMF) over Frailty Index (FI) in predicting self-rated health and functional dependency amongst near-centenarians and centenarians.
  
  
  METHODS
  Cross-sectional, community-based study.
  
  
  METHODS
  Two community-based social and clinical networks.
  
  
  METHODS
  One hundred twenty-four community-dwelling Chinese near-centenarians and centenarians.
  
  
  METHODS
  Frailty was first assessed using a 32-item FI (FI-32). Then, a new CMF was constructed by adding 12 items in the psychological, social/family, environmental, and economic domains to the FI-32. Hierarchical multiple regressions explored whether the new CMF provided significant additional predictive power for self-rated health and instrumental activities of daily living (IADL) dependency.
  
  
  RESULTS
  Mean age was 97.7 (standard deviation 2.3) years, with a range from 95 to 108, and 74.2% were female. Overall, 16% of our participants were nonfrail, 59% were prefrail, and 25% were frail. Frailty according to FI-32 significantly predicted self-rated health and IADL dependency beyond the effect of age and gender. Inclusion of the new CMF into the regression models provided significant additional predictive power beyond FI-32 on self-rated health, but not IADL dependency.
  
  
  CONCLUSIONS
  A CMF should ideally be a multidimensional and multidisciplinary construct including physical, cognitive, functional, psychosocial/family, environmental, and economic factors.
authors: Department of Medicine, The University of Hong Kong, Hong Kong, China. Electronic address: jskkwan@hku.hk.
authors: Joseph Shiu Kwong
authors: JS
authors: Kwan
authors: Department of Psychology, The University of Hong Kong, Hong Kong, China.
authors: Bobo Hi Po
authors: BH
authors: Lau
authors: Sau Po Center on Aging and Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong, China.
authors: Karen Siu Lan
authors: KS
authors: Cheung
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment; D006723:Hong Kong; D006801:Humans; D007407:Interviews as Topic; D008297:Male
keywords: Centenarians; aging; frailty; multidisciplinary; psychosocial