title: In-vitro anthelmintic activity of three Bangladeshi plants against Paramphistomum cervi and Haemonchus contortus.
abstract: BACKGROUND
  Conventional plant-based therapies act as an important therapeutic tool for the treatment of worm infections all over the world and continuous evaluation of medicinal plants to find new potential lead compounds should be carried out.
  
  
  METHODS
  In-vitro analysis was conducted to evaluate the probable anthelmintic effect of crude aqueous and hydroalcoholic extracts of Ananas sativus leaves, Erythrina variegata barks and Alocasia indica rootstocks, against adult Paramphistomum cervi (Trematoda) and Haemonchus contortus (Nematode).
  
  
  RESULTS
  Among all three concentrations (25, 50, and 100 mg/mL), the hydroalcoholic leaf extract of A. sativus exhibited paralysis and death time ranged between 7.26 to 26.76 min and 15.40 to 35.55 min respectively for P. cervi while that for H. contortus was 14.70 to 42.43 min and 23.43 to 56.34 min, respectively. Moreover, aqueous extract exhibited paralysis and death time ranged between 7.66 to 28.72 min and 18.30 to 33.00 min, respectively, for P. cervi whereas paralysis and death time ranged between 23.34 to 37.88 min and 31.08 to 58.30 min respectively for H. contortus. Both extracts of E. variegata bark and A. indica tuber showed comparatively less significant anthelmintic activity. All results were statistically significant (p < 0.001).
  
  
  CONCLUSIONS
  A. sativus leaf displayed favorable anthelmintic activity on both P. cervi and H. contortus, whereas E. variegata barks and A. indica rootstocks showed insignificant result.
authors: Md Khirul
authors: MK
authors: Islam
authors: Md Afjalus
authors: MA
authors: Siraj
authors: Asit Baron
authors: AB
authors: Sarker
authors: Sanjib
authors: S
authors: Saha
authors: Imran
authors: I
authors: Mahmud
authors: Md Mustafizur
authors: MM
authors: Rahman
mesh_terms: D031055:Alocasia; D031230:Ananas; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D000977:Antiparasitic Agents / Q000494:pharmacology; D002417:Cattle; D004895:Erythrina; D006188:Haemonchiasis / Q000469:parasitology; D006189:Haemonchus / Q000187:drug effects*; D010250:Paramphistomatidae / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D018514:Plant Structures; D014201:Trematode Infections / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D000977:Antiparasitic Agents; D010936:Plant Extracts