title: HIV vaccine research: the challenge and the way forward.
abstract: Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a worldwide epidemic, with over 35 million people infected currently. Therefore, the development of a safe and effective HIV-1 vaccine is on top of the global health priority. In the past few years, there have been many promising advances in the prevention of HIV/AIDS, among which the RV144 Thai trial has been encouraging and suggests optimization of the current vaccine strategies or search for novel strategies. Here we reviewed the brief history of HIV-1 vaccine, analyzed key challenges existing now, and illustrated future research priority/directions for a therapeutic or prophylactic HIV-1 vaccine, with the hope of accelerating the speed of vaccine development. We believe that an effective HIV-1 vaccine, together with other prevention approaches, will bring an end to this epidemic in the near future.
authors: Zhuhai International Travel Healthcare Center, Zhuhai Entry-Exit Inspection and Quarantine Bureau, Zhuhai, Guangdong 519020, China.
authors: Hai-Bo
authors: HB
authors: Wang
authors: Zhuhai International Travel Healthcare Center, Zhuhai Entry-Exit Inspection and Quarantine Bureau, Zhuhai, Guangdong 519020, China.
authors: Qiu-Hua
authors: QH
authors: Mo
authors: Zhuhai International Travel Healthcare Center, Zhuhai Entry-Exit Inspection and Quarantine Bureau, Zhuhai, Guangdong 519020, China.
authors: Ze
authors: Z
authors: Yang
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D012106:Research / Q000639:trends
chemical_list: D016915:AIDS Vaccines