title: Genetic Variant in the CYP19A1 Gene Associated with Coronary Artery Disease.
abstract: The CYP19A1 gene encodes the enzyme aromatase, which is responsible for the biosynthesis of estrogens. The rs10046 polymorphism of CYP19A1 gene has been investigated in two studies on the occurrence of hypertension, but there are no studies on its correlation with coronary artery disease (CAD). We investigated 189 subjects who were hospitalized at "KAT" General Hospital of Athens and underwent coronary angiography. Of these, 123 were found with CAD with an average age of 60 years and constituted the patients group and 66 subjects with an average age of 58 years without damage in the coronary vessels and constituted the control group (healthy). The frequencies of genotypes CC, CT, and TT of rs10046 polymorphism are significantly different between the group of CAD patients and the control group (0.34, 0.48, and 0.18 versus 0.20, 0.48, and 0.32, resp., P = 0.034) as the frequency of C allele (0.58 versus 0.44, resp., OR = 1.771 and P = 0.010). We found similar results for men, but not for women (small sample). The results of this study show that the rs10046 (C/T) polymorphism of CYP19A1 gene exhibits correlation with CAD and that patients with C allele have an increased probability of manifesting the disease.
authors: Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, 15784 Athens, Greece.
authors: Konstantina
authors: K
authors: Bampali
authors: Department of Cardiology, General Hospital "KAT", 14561 Athens, Greece.
authors: Charalampos
authors: C
authors: Grassos
authors: Department of Cardiology, General Hospital "KAT", 14561 Athens, Greece.
authors: Angeliki
authors: A
authors: Mouzarou
authors: Department of Cardiology, General Hospital "KAT", 14561 Athens, Greece.
authors: Charalampos
authors: C
authors: Liakos
authors: Department of Cardiology, General Hospital "KAT", 14561 Athens, Greece.
authors: Georgios
authors: G
authors: Mertzanos
authors: Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, 15784 Athens, Greece.
authors: Klea
authors: K
authors: Lamnissou
authors: Department of Cardiology, General Hospital "KAT", 14561 Athens, Greece.
authors: Dimitrios
authors: D
authors: Babalis