title: Gamma activity model for treatment-resistant bipolar psychotic mania.
abstract: OBJECTIVE
  The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania.
  
  
  METHODS
  Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30-49 Hz gamma spectral power.
  
  
  RESULTS
  Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found.
  
  
  CONCLUSIONS
  We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.
authors: Department of Psychiatry and K. S. Mani Center for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand, India.
authors: Shashi Ranjan
authors: SR
authors: Kumar
authors: Department of Psychiatry and K. S. Mani Center for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand, India.
authors: Vinod Kumar
authors: VK
authors: Sinha
authors: Department of Psychiatry and K. S. Mani Center for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand, India.
authors: Sai Krishna
authors: SK
authors: Tikka
authors: Department of Psychiatry and K. S. Mani Center for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand, India.
authors: Nishant
authors: N
authors: Goyal
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D004351:Drug Resistance; D007839:Functional Laterality; D065818:Gamma Rhythm / Q000187:drug effects*; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D008094:Lithium
keywords: Bipolar psychotic mania; gamma activity; spectral power; treatment resistance