title: Serum levels of procalcitonin and high sensitivity C-reactive protein are associated with long-term mortality in acute ischemic stroke.
abstract: OBJECTIVE
  The aim of this study is to assess the prognostic value of systemic inflammation, as measured by the inflammatory biomarkers PCT and Hs-CRP, to predict the long-term mortality in ischemic stroke patients.
  
  
  METHODS
  We prospectively studied 374 patients with ischemic stroke who were admitted within 24h after the onset of symptoms. Serum levels of PCT, Hs-CRP and NIH stroke scale (NIHSS) were measured at the time of admission. Clinical follow-up was performed at 1 year. The prognostic value of PCT to predict the mortality within one year was compared with Hs-CRP, NIHSS and with other known outcome predictors.
  
  
  RESULTS
  In the 64 non-survival patients, serum PCT levels were significantly (P<0.0001) higher compared with those in survival patients. Multivariate COX regression analysis showed that log-transformed PCT and Hs-CRP were independent mortality predictors with adjusted hazard ratio of 4.24 (95% confidence interval [CI], 2.42-6.30) and 15.37 (95% confidence interval [CI], 3.25-41.08). The area under the receiver operating characteristic curve of PCT and Hs-CRP were 0.89 (95% CI, 0.85-0.93) and 0.68 (95% CI, 0.59-0.77) for mortality, respectively.
  
  
  CONCLUSIONS
  Serum levels of PCT and HS-CRP at admission were independent predictor of long-term mortality after ischemic stroke in a Chinese sample.
authors: Department of Neurology, Yangpu Hospital, Tongji University School of Medicine, Shanghai 20090, China.
authors: You-Mei
authors: YM
authors: Li
authors: Department of Neurology, Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, China. Electronic address: ttz371@163.com.
authors: Xue-Yuan
authors: XY
authors: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000401:mortality / Q000503:physiopathology; D002097:C-Reactive Protein / Q000032:analysis*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood* / Q000401:mortality / Q000503:physiopathology; D013997:Time Factors
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide
keywords: Acute ischemic stroke; Chinese; High sensitivity C-reactive protein; Mortality; Procalcitonin