title: The Pseudomonas Quinolone Signal Inhibits Biofilm Development of Streptococcus mutans.
abstract: Bacteria often thrive in natural environments through a sessile mode of growth, known as the biofilm. Biofilms are well-structured communities and their formation is tightly regulated. However, the mechanisms by which interspecies interactions alter the formation of biofilms have not yet been elucidated in detail. We herein demonstrated that a quorum-sensing signal in Pseudomonas aeruginosa (the Pseudomonas quinolone signal; PQS) inhibited biofilm formation by Streptococcus mutans. Although the PQS did not affect cell growth, biofilm formation was markedly inhibited. Our results revealed a unique role for this multifunctional PQS and also indicated its application in the development of prophylactic agents against caries-causing S. mutans.
authors: Graduate School of Life and Environmental Sciences, University of Tsukuba.
authors: Tomohiro
authors: T
authors: Inaba
authors: Hiromu
authors: H
authors: Oura
authors: Kana
authors: K
authors: Morinaga
authors: Masanori
authors: M
authors: Toyofuku
authors: Nobuhiko
authors: N
authors: Nomura
mesh_terms: D000898:Antibiosis; D018441:Biofilms / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D015363:Quinolones / Q000378:metabolism*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000502:physiology*
chemical_list: C407944:2-heptyl-3-hydroxy-4-quinolone; D015363:Quinolones