title: Is there a role for ADORA2A polymorphisms in levodopa-induced dyskinesia in Parkinson's disease patients?
abstract: OBJECTIVE
  Levodopa is first line treatment of Parkinson's disease (PD). However, its use is associated with the presence of motor fluctuations and dyskinesias. In recent years, adenosine A2A receptor (A2AR) is rising as a therapeutic target for PD. The aim of the present study was to investigate whether ADORA2A is associated with levodopa adverse effects.
  
  
  METHODS
  Two hundred and eight PD patients on levodopa therapy were investigated. rs2298383 and rs3761422 at the ADORA2A gene were genotyped by allelic discrimination assays.
  
  
  RESULTS
  A trend for association was observed for both polymorphism and diplotypes with dyskinesia.
  
  
  CONCLUSIONS
  The present results should be considered as positive preliminary evidence. Further studies are needed to determine the association between ADORA2A and dyskinesia. Original submitted 3 December 2014; Revision submitted 13 February 2015.
authors: Departmento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Caixa postal 15053, Porto Alegre, RS, 91501-970, Brazil.
authors: Mariana
authors: M
authors: Rieck
authors: Artur F
authors: AF
authors: Schumacher-Schuh
authors: Sidia M
authors: SM
authors: Callegari-Jacques
authors: Vivian
authors: V
authors: Altmann
authors: Márcio
authors: M
authors: Schneider Medeiros
authors: Carlos Rm
authors: CR
authors: Rieder
authors: Mara H
authors: MH
authors: Hutz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D043705:Receptor, Adenosine A2A / Q000502:physiology*
chemical_list: D043705:Receptor, Adenosine A2A; D007980:Levodopa
keywords: ADORA2A; Parkinson's disease; dyskinesia; levodopa