title: Male Gender and Arterial Hypertension are Plaque Predictors at Coronary Computed Tomography Angiography.
abstract: BACKGROUND
  Systemic Arterial Hypertension (SAH) is one of the main risk factors for Coronary Artery Disease (CAD), in addition to male gender. Differences in coronary artery lesions between hypertensive and normotensive individuals of both genders at the Coronary Computed Tomography Angiography (CCTA) have not been clearly determined.
  
  
  OBJECTIVE
  To Investigate the calcium score (CS), CAD extent and characteristics of coronary plaques at CCTA in men and women with and without SAH.
  
  
  METHODS
  Prospective cross-sectional study of 509 patients undergoing CCTA for CAD diagnosis and risk stratification, from November 2011 to December 2012, at Instituto de Cardiologia Dante Pazzanese. Individuals were stratified according to gender and subdivided according to the presence (HT +) or absence (HT-) of SAH.
  
  
  RESULTS
  HT+ women were older (62.3 ± 10.2 vs 57.8 ± 12.8, p = 0.01). As for the assessment of CAD extent, the HT+ individuals of both genders had significant CAD, although multivessel disease is more frequent in HT + men. The regression analysis for significant CAD showed that age and male gender were the determinant factors of multivessel disease and CS ≥ 100. Plaque type analysis showed that SAH was a predictive risk factor for partially calcified plaques (OR = 3.9).
  
  
  CONCLUSIONS
  Hypertensive men had multivessel disease more often than women. Male gender was a determinant factor of significant CAD, multivessel disease, CS ≥ 100 and calcified and partially calcified plaques, whereas SAH was predictive of partially calcified plaques.
authors: Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors: Joselina Luzia Menezes
authors: JL
authors: Oliveira
authors: Universidade de São Paulo, São Paulo, SP, Brazil.
authors: Mario Hiroyuki
authors: MH
authors: Hirata
authors: Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, Brazil.
authors: Amanda Guerra de Moraes Rego
authors: AG
authors: Sousa
authors: Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, Brazil.
authors: Fabíola Santos
authors: FS
authors: Gabriel
authors: Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, Brazil.
authors: Thiago Dominguez Crespo
authors: TD
authors: Hirata
authors: Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors: Irlaneide da Silva
authors: Ida S
authors: Tavares
authors: Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors: Luiza Dantas
authors: LD
authors: Melo
authors: Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors: Fabiana de Santana
authors: Fde S
authors: Dória
authors: Universidade Federal de Sergipe, Aracaju, SE, Brazil.
authors: Antônio Carlos Sobral
authors: AC
authors: Sousa
authors: Instituto Dante Pazzanese de Cardiologia, São Paulo, SP, Brazil.
authors: Ibraim Masciarelli Francisco
authors: IM
authors: Pinto
mesh_terms: D000367:Age Factors; D000368:Aged; D002118:Calcium / Q000032:analysis; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging*; D018570:Risk Assessment / Q000379:methods; D012720:Severity of Illness Index; D012737:Sex Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*; D061205:Vascular Calcification / Q000000981:diagnostic imaging*
chemical_list: D002118:Calcium