title: Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility.
abstract: Human-like collagen (HLC)-coated monodispersed superparamagnetic Fe3O4 nanoparticles have been successfully prepared to investigate its effect on heat induction property and cell toxicity. After coating of HLC, the sample shows a faster rate of temperature increase under an alternating magnetic field although it has a reduced saturation magnetization. This is most probably a result of the effective heat conduction and good colloid stability due to the high charge of HLC on the surface. In addition, compared with Fe3O4 nanoparticles before coating with HLC, HLC-coated Fe3O4 nanoparticles do not induce notable cytotoxic effect at higher concentration which indicates that HLC-coated Fe3O4 nanoparticles has improved biocompatibility. Our results clearly show that Fe3O4 nanoparticles after coating with HLC not only possess effective heat induction for cancer treatment but also have improved biocompatibility for biomedicine applications.
authors: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China ; Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1, Singapore, 117574 Singapore.
authors: Xiaoli
authors: X
authors: Liu
authors: School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China.
authors: Huan
authors: H
authors: Zhang
authors: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China.
authors: Le
authors: L
authors: Chang
authors: Institute of Photonics & Photon-Technology, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China.
authors: Baozhi
authors: B
authors: Yu
authors: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China.
authors: Qiuying
authors: Q
authors: Liu
authors: Institute of Photonics & Photon-Technology, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China.
authors: Jianpeng
authors: J
authors: Wu
authors: School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China.
authors: Yuqing
authors: Y
authors: Miao
authors: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China.
authors: Pei
authors: P
authors: Ma
authors: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China.
authors: Daidi
authors: D
authors: Fan
authors: Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, Shaanxi 710069 China.
authors: Haiming
authors: H
authors: Fan
keywords: Biocompatibility; Human-like collagen; Magnetic hyperthermia; Magnetic nanoparticles