title: The outcomes and treatment burden of childhood acute myeloid leukaemia in Australia, 1997-2008: A report from the Australian Paediatric Cancer Registry.
abstract: Childhood acute myeloid leukaemia (AML) requires intensive therapy and is associated with survival rates that are substantially inferior to many other childhood malignancies. We undertook a retrospective analysis of Australian Paediatric Cancer Registry data from 1997 to 2008 together with a single-centre audit during the same period assessing burden on service delivery at a tertiary children's hospital (Royal Children's Hospital, Brisbane). Although survival improved from 54.3% (1997-2002) to 69.2% (2003-2008), childhood AML caused a disproportionate number of childhood cancer deaths, accounting for 5.5% of all childhood cancer diagnoses yet 7.9% of all childhood cancer mortality. Furthermore, treatment was associated with significant toxicity requiring intensive use of local health resources. Novel therapeutic strategies aimed at improving survival and reducing toxicity are urgently required.
authors: Oncology Service, Children's Health Queensland Hospital and Health Service, Brisbane, Australia.
authors: Steven A
authors: SA
authors: Foresto
authors: Cancer Council Queensland, Brisbane, Australia.
authors: Danny R
authors: DR
authors: Youlden
authors: Cancer Council Queensland, Brisbane, Australia.|School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia.|Griffith Health Institute, Griffith University, Gold Coast, Australia.
authors: Peter D
authors: PD
authors: Baade
authors: Oncology Service, Children's Health Queensland Hospital and Health Service, Brisbane, Australia.|Queensland Children's Medical Research Institute, Children's Health Queensland Hospital and Health Service, Brisbane, Australia.|UQ Child Health Research Centre, The University of Queensland, Brisbane, Australia.
authors: Andrew R
authors: AR
authors: Hallahan
authors: Cancer Council Queensland, Brisbane, Australia.|School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia.|Griffith Health Institute, Griffith University, Gold Coast, Australia.
authors: Joanne F
authors: JF
authors: Aitken
authors: Oncology Service, Children's Health Queensland Hospital and Health Service, Brisbane, Australia.|Queensland Children's Medical Research Institute, Children's Health Queensland Hospital and Health Service, Brisbane, Australia.|UQ Child Health Research Centre, The University of Queensland, Brisbane, Australia.|The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, Australia.
authors: Andrew S
authors: AS
authors: Moore
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001315:Australia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D017281:Cost of Illness; D003428:Cross Infection / Q000453:epidemiology; D005260:Female; D006295:Health Resources / Q000706:statistics & numerical data*; D018380:Hematopoietic Stem Cell Transplantation; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data; D007902:Length of Stay / Q000706:statistics & numerical data; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000453:epidemiology* / Q000628:therapy; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy; D008297:Male; D009894:Opportunistic Infections / Q000453:epidemiology; D012042:Registries; D012189:Retrospective Studies; D015996:Survival Rate; D062606:Tertiary Care Centers / Q000706:statistics & numerical data; D016896:Treatment Outcome
keywords: acute myeloid leukaemia; epidemiology; paediatric