title: A software platform for phase contrast x-ray breast imaging research.
abstract: OBJECTIVE
  To present and validate a computer-based simulation platform dedicated for phase contrast x-ray breast imaging research.
  
  
  METHODS
  The software platform, developed at the Technical University of Varna on the basis of a previously validated x-ray imaging software simulator, comprises modules for object creation and for x-ray image formation. These modules were updated to take into account the refractive index for phase contrast imaging as well as implementation of the Fresnel-Kirchhoff diffraction theory of the propagating x-ray waves. Projection images are generated in an in-line acquisition geometry. To test and validate the platform, several phantoms differing in their complexity were constructed and imaged at 25 keV and 60 keV at the beamline ID17 of the European Synchrotron Radiation Facility. The software platform was used to design computational phantoms that mimic those used in the experimental study and to generate x-ray images in absorption and phase contrast modes.
  
  
  RESULTS
  The visual and quantitative results of the validation process showed an overall good correlation between simulated and experimental images and show the potential of this platform for research in phase contrast x-ray imaging of the breast. The application of the platform is demonstrated in a feasibility study for phase contrast images of complex inhomogeneous and anthropomorphic breast phantoms, compared to x-ray images generated in absorption mode.
  
  
  CONCLUSIONS
  The improved visibility of mammographic structures suggests further investigation and optimisation of phase contrast x-ray breast imaging, especially when abnormalities are present. The software platform can be exploited also for educational purposes.
authors: Department of Electronics, Technical University of Varna, 1 Studentska Str, Varna 9010, Bulgaria. Electronic address: kristina.bliznakova@tu-varna.bg.
authors: K
authors: K
authors: Bliznakova
authors: Dipartimento di Fisica, Università di Napoli Federico II, and INFN Sezione di Napoli, Via Cintia, I-80126 Naples, Italy.
authors: P
authors: P
authors: Russo
authors: Dipartimento di Fisica, Università di Napoli Federico II, and INFN Sezione di Napoli, Via Cintia, I-80126 Naples, Italy.
authors: G
authors: G
authors: Mettivier
authors: European Synchrotron Radiation Facility (ESRF), Grenoble F-38043, France.
authors: H
authors: H
authors: Requardt
authors: Department of Physics, Technical University of Varna, 1 Studentska Str, Varna 9010, Bulgaria.
authors: P
authors: P
authors: Popov
authors: European Synchrotron Radiation Facility (ESRF), Grenoble F-38043, France.
authors: A
authors: A
authors: Bravin
authors: Department of Electronics, Technical University of Varna, 1 Studentska Str, Varna 9010, Bulgaria.
authors: I
authors: I
authors: Buliev
mesh_terms: D001940:Breast; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008327:Mammography / Q000295:instrumentation / Q000379:methods; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D012984:Software
keywords: Breast imaging; Breast phantoms; In-line x-ray Imaging; Modelling and simulation; Phase contrast imaging; Synchrotron facilities