title: Regiospecific Hetero-Assembly of DNA-Functionalized Plasmonic Upconversion Superstructures.
abstract: We report a novel strategy for regiospecific hetero-assembly of DNA-modified gold nanoparticles (DNA-AuNPs) onto upconversion nanoparticles (UCNPs) into hybrid lab-on-a-particle systems. The DNA-AuNPs have been assembled onto the hexagonal plate-like UCNPs with well-regulated stoichiometry and controlled organization onto the different facets of UCNP, forming various addressable superstructures. The fine-tuning of stoichiometry and organization is realized by biorecognition specificity of DNA toward specific crystal facets of UCNPs. Such a hetero-assembled DNA-AuNP/UCNP system maintains both plasmonic resonance of AuNPs and fluorescent properties of UCNPs, allowing targeted dual-modality imaging of cancer cells using an aptamer.
authors: Department of Chemistry, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
authors: Le-Le
authors: LL
authors: Li
authors: Department of Chemistry, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
authors: Yi
authors: Y
authors: Lu
mesh_terms: D000818:Animals; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D001943:Breast Neoplasms / Q000175:diagnosis*; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D061848:Optical Imaging; D010750:Phosphoproteins / Q000032:analysis*; D016601:RNA-Binding Proteins / Q000032:analysis*; D013237:Stereoisomerism; D000097796:Nucleolin
chemical_list: D052157:Aptamers, Nucleotide; D004247:DNA; D005456:Fluorescent Dyes; D006046:Gold; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D000097796:Nucleolin