title: Biomechanical and Histomorphometrical Evaluation of TiZr Alloy Implants: An in vivo Study in the Rabbit.
abstract: BACKGROUND
  Clinically, there is a demand for mechanically stronger alloyed implants; however, not much evidence exists with regard to these materials.
  
  
  OBJECTIVE
  To test the osseointegration property of TiZr1317 implants in a rabbit model.
  
  
  METHODS
  Hydrophilic titanium-zirconium alloy (TiZr1317) implants with sand-blasted and acid-etched surface (test) and hydrophilic cpTi implants with the same treatment (control) were placed pairwise in the hind limbs (two in each tibia and one in each femur) of 36 Swedish lop-eared rabbits. After 2, 4, and 12 weeks (n = 12/time point), the bone samples were subjected to removal torque (RTQ, proximal tibia and femur) and histologic/histomorphometric (distal tibia) testings.
  
  
  RESULTS
  The control presented significantly higher RTQ than the test at 2 weeks (55 vs 36 Ncm). No differences were observed for other time points. The test presented higher mean BIC than the control (19.25 vs 13.89 %) at 4 weeks; however, there were no statistical differences for the following time point tested in vivo.The new bone area was significantly higher for the test at 4 weeks in the marrow areas.
  
  
  CONCLUSIONS
  The TiZr1317 implants presented comparable biologic outcomes to that of the cpTi implants through a 12-week evaluation period.
authors: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors: Ryo
authors: R
authors: Jimbo
authors: Department of Oral and Maxillofacial Prosthodontics and Oral Implantology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors: Yoshihito
authors: Y
authors: Naito
authors: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors: Silvia
authors: S
authors: Galli
authors: Institut Straumann AG, Basel, Switzerland.
authors: Simon
authors: S
authors: Berner
authors: Institut Straumann AG, Basel, Switzerland.|Department of Periodontics, New York University College of Dentistry, New York, NY, USA.
authors: Michel
authors: M
authors: Dard
authors: Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
authors: Ann
authors: A
authors: Wennerberg
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D003722:Dental Alloys / Q000627:therapeutic use*; D005260:Female; D005269:Femur / Q000601:surgery; D008297:Male; D016348:Osseointegration; D019736:Prostheses and Implants; D011817:Rabbits; D013977:Tibia / Q000601:surgery; D014025:Titanium / Q000627:therapeutic use*; D019415:Torque; D015040:Zirconium / Q000627:therapeutic use*
chemical_list: D003722:Dental Alloys; D015040:Zirconium; D014025:Titanium
keywords: animal study; bone-implant interface; histological analysis