title: Major complications of adult right lobe living liver donors.
abstract: BACKGROUND
  The right lobe of the liver is generally preferred for living donor liver transplantation in adult patients with end-stage liver disease. It is important to know the preoperative factors relating to the major postoperative complications. We therefore evaluated the possible risk factors for predicting postoperative complications in right lobe liver donors.
  
  
  METHODS
  Data from 378 donors who had undergone right lobe hepatectomy at our center were evaluated retrospectively. The factors we evaluated included donor age, gender, body mass index (BMI), remnant liver volume, operation time, history of previous abdominal surgery, inclusion of the middle hepatic vein and variations in the portal and bile systems.
  
  
  RESULTS
  Of the 378 donors, 219 were male and 159 female. None of the donors died, but 124 (32.8%) donors experienced complications including major complications (Clavien scores III and IV) in 27 (7.1%). Univariate analysis showed that complications were significantly associated with male gender and higher BMI (P<0.05), but not with donor age, remnant liver volume, operation time, graft with middle hepatic vein, variations in the portal and bile systems and previous abdominal surgery (P<0.05). Multivariate logistic regression analysis showed that major complications were significantly associated with male gender (P=0.005) and higher BMI (P=0.029). Moreover, the Chi-square test showed that there were significant relationships between major complications and male gender (P=0.010, X2=6.614, df=1) and BMI >25 kg/m2 (P=0.031, X2=8.562, df=1). Of the 96 male donors with BMI >25 kg/m2, 14 (14.6%) with major complications had significantly smaller mean remnant liver volume than those (82, 85.4%) without major complications (32.50%+/-4.45% vs 34.63%+/-3.11%, P=0.029).
  
  
  CONCLUSIONS
  Male donors with BMI >25 kg/m2 and a remnant liver volume ≤32.50% had a significantly increased risk for major complications.
authors: Liver Transplantation Center, Florence Nightingale Hospital, Istanbul, Turkey. necdetguler1907@hotmail.com.
authors: Necdet
authors: N
authors: Guler
authors: Onur
authors: O
authors: Yaprak
authors: Yusuf
authors: Y
authors: Gunay
authors: Murat
authors: M
authors: Dayangac
authors: Murat
authors: M
authors: Akyildiz
authors: Fisun
authors: F
authors: Yuzer
authors: Yildiray
authors: Y
authors: Yuzer
authors: Yaman
authors: Y
authors: Tokat
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D008099:Liver / Q000033:anatomy & histology*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D009929:Organ Size; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors