title: Effect of high-molecular-weight component of Cranberry on plaque and salivary Streptococcus mutans counts in children: an in vivo study.
abstract: BACKGROUND
  Previous investigations showed that a high-molecular-weight, nondialyzable material (NDM) from cranberries inhibits the adhesion of a number of bacterial species and prevents the coaggregation of many oral bacterial pairs.
  
  
  OBJECTIVE
  In the present study, the effect of mouthrinse containing high-molecular-weight component of cranberry was evaluated on colonization of Streptococcus mutans in children and compared it with a control mouthrinse without high-molecular-weight component on Streptococcus mutans counts.
  
  
  METHODS
  A high-molecular-weight NDM was isolated from cranberry juice concentrate after the dialysis of the cranberry concentrate; followed by lyophilization. A mouthwash was prepared especially for the study having NDM in the concentration of 3 mg/ml. Following 4 weeks of daily usage of cranberry-containing mouthwash by the children of an experimental group (n = 20), the Streptococcus mutans counts in plaque and saliva were compared with that in control group using placebo mouthwash (n = 20) with the help of Dentocult SM strips.
  
  
  RESULTS
  There was a highlysignificant reduction in Streptococcus mutans counts in saliva and plaque of children using mouthwash containing cranberry NDM (P < 0.05) compared to control.
  
  
  CONCLUSIONS
  The data suggest that the high-molecular-weight cranberry extract in mouthwash has a significant potential in reducing the Streptococcus counts in the oral environment.
authors: Akanksha
authors: A
authors: Gupta
authors: Department of Pedodontics and Preventive Dentistry, Sri Gobind Tricentenary Dental College and Research Institute, Budhera, Gurgaon, Haryana, India.
authors: Kalpana
authors: K
authors: Bansal
authors: Mohita
authors: M
authors: Marwaha
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects*; D002648:Child; D015169:Colony Count, Microbial; D004245:DMF Index; D003773:Dental Plaque / Q000188:drug therapy* / Q000382:microbiology*; D003774:Dental Plaque Index; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D009067:Mouthwashes / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects*; D014099:Toothbrushing; D029799:Vaccinium macrocarpon / Q000737:chemistry*
chemical_list: D009067:Mouthwashes; D010936:Plant Extracts