title: Effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia.
abstract: This study aimed to evaluate the effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia. Male Wistar rats underwent Cecal Ligation and Perporation (CLP) with "basic support" or were sham-operated. After 30 days, the animals were submitted to a model of schizophrenia by injection of Ketamine. The behavior tests were performed after 30 min of the injection of Ketamine or saline. Ketamine in doses of 15 and 25mg/kg increased locomotor activity, latency to first contact in the social interaction and stereotyped behavior. Some changes caused by sepsis may be associated with a predisposition to develop schizophrenia in the animal model.
authors: Laboratory of Neuropathology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil. Electronic address: clarissamc@gmail.com.br.
authors: Clarissa M
authors: CM
authors: Comim
authors: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors: Napoleão C
authors: NC
authors: Silva
authors: Laboratory of Neuropathology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil.
authors: Janini J
authors: JJ
authors: Patrício
authors: Laboratory of Neuropathology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil.
authors: Daphne
authors: D
authors: Palmas
authors: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors: Bruna P
authors: BP
authors: Mendonça
authors: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors: Mariana O
authors: MO
authors: Bittencourt
authors: Laboratory of Neuropathology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil.
authors: Omar J
authors: OJ
authors: Cassol
authors: Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors: Tatiana
authors: T
authors: Barichello
authors: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors: Alexandra I
authors: AI
authors: Zugno
authors: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil; Center for Experimental Models in Psychiatry, Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School at Houston, Houston, TX, USA.
authors: João
authors: J
authors: Quevedo
authors: Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors: Felipe
authors: F
authors: Dal-Pizzol
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007398:Interpersonal Relations; D007649:Ketamine / Q000633:toxicity*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012559:Schizophrenia / Q000139:chemically induced*; D012565:Schizophrenic Psychology; D018805:Sepsis / Q000150:complications / Q000523:psychology*
chemical_list: D007649:Ketamine
keywords: Behavior; Brain; Schizophrenia; Sepsis