title: Association of functional genetic variants of A-kinase anchoring protein 10 with QT interval length in full-term Polish newborns.
abstract: BACKGROUND
  A-Kinase Anchoring Proteins (AKAPs) coordinate the specificity of protein kinase A signaling by localizing the kinase to subcellular sites. The 1936G (V646) AKAP10 allele has been associated in adults with low cholinergic/vagus nerve sensitivity, shortened PR intervals in ECG recording and in newborns with increased blood pressure and higher cholesterol cord blood concentration. The aim of the study was to answer the question of whether 1936A > G AKAP10 polymorphism is associated with the newborn electrocardiographic variables.
  
  
  METHODS
  Electrocardiograms were recorded from 114 consecutive healthy Polish newborns (55 females, 59 males), born after 37 gestational weeks to healthy women with uncomplicated pregnancies. All recordings were made between 3(rd) and 7(th) day of life to avoid QT variability. The heart rate per minute and duration of PR, QRS, RR and QT intervals were usually measured. The ECGs were evaluated independently by three observers. At birth, cord blood of neonates was obtained for isolation of genomic DNA.
  
  
  RESULTS
  The distribution of anthropometric and electrocardiographic variables in our cohort approached normality (skewness < 2 for all variables). No significant differences in anthropometric variables and electrocardiographic traits with respect to AKAP10 genotype were found. Multiple regression analysis with adjustment for gender, gestational age and birth mass revealed that QTc interval in GG AKAP10 homozygotes was significantly longer, but in range, when compared with A alleles carriers (AA + AG, recessive mode of inheritance). No rhythm disturbances were observed.
  
  
  CONCLUSIONS
  Results demonstrate possible association between AKAP10 1936A > G variant and QTc interval in Polish newborns.
authors: Department of Neonatal Disease, Pomeranian Medical University, Szczecin, Poland.
authors: Beata
authors: B
authors: Łoniewska
authors: Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland.
authors: Mariusz
authors: M
authors: Kaczmarczyk
authors: Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland.
authors: Jeremy Simon
authors: JS
authors: Clark
authors: Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland.
authors: Iwona
authors: I
authors: Gorący
authors: Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Children's Cardiology, Pomeranian Medical University, Szczecin, Poland.
authors: Anita
authors: A
authors: Horodnicka-Józwa
authors: Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland.
authors: Andrzej
authors: A
authors: Ciechanowicz
keywords: A-kinase-anchoring protein 10; QT interval; electrocardiograph; genetic polymorphism; newborns