title: A trinuclear oxo-chromium(III) complex containing the natural flavonoid primuletin: synthesis, characterization, and antiradical properties.
abstract: A new trinuclear oxo-centered chromium(III) complex with formula [Cr3O(CH3CO2)6(L)(H2O)2] (L = 5-hydroxyflavone, known as primuletin) was synthetized and characterized by ESI mass spectrometry, thermogravimetry, and 1H-NMR, UV-Vis, and FTIR spectroscopies. In agreement with the experimental results, DFT calculations indicated that the flavonoid ligand is coordinated to one of the three Cr(III) centers in an O,O-bidentate mode through the 5-hydroxy/4-keto groups. In a comparative study involving the uncoordinated primuletin and its corresponding complex, systematic reactions with the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) showed that antiradical activity increases upon complexation.
authors: Escola de Engenharia, Universidade Presbiteriana Mackenzie, Rua da Consolação 930, São Paulo, SP CEP 01302-000, Brazil. anamaria.alexiou@mackenzie.br.
authors: Anamaria D P
authors: AD
authors: Alexiou
authors: Escola de Engenharia, Universidade Presbiteriana Mackenzie, Rua da Consolação 930, São Paulo, SP CEP 01302-000, Brazil. carla.decandio@ufabc.edu.br.
authors: Carla C
authors: CC
authors: Decandio
authors: Escola de Engenharia, Universidade Presbiteriana Mackenzie, Rua da Consolação 930, São Paulo, SP CEP 01302-000, Brazil. sabrina-nobrega@usp.br.
authors: Sabrina da N
authors: Sda N
authors: Almeida
authors: Departamento de Botânica, Instituto de Biociências, Universidade de São Paulo, Rua do Matão, 277, São Paulo, SP CEP 05508-090, Brazil. marcelopena@ib.usp.br.
authors: Marcelo J P
authors: MJ
authors: Ferreira
authors: Escola de Engenharia, Universidade Presbiteriana Mackenzie, Rua da Consolação 930, São Paulo, SP CEP 01302-000, Brazil. paulete.romoff@mackenzie.br.
authors: Paulete
authors: P
authors: Romoff
authors: Los Alamos National Laboratory, Los Alamos, NM 87545, USA. rcrocha@lanl.gov.
authors: Reginaldo C
authors: RC
authors: Rocha
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry*; D002857:Chromium / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010851:Picrates / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry
chemical_list: D001713:Biphenyl Compounds; D005419:Flavonoids; D005609:Free Radicals; D008024:Ligands; D010851:Picrates; D002857:Chromium; C062711:5-hydroxyflavone; C004931:1,1-diphenyl-2-picrylhydrazyl