title: The effect of prophylactic migraine treatment on arterial stiffness.
abstract: BACKGROUND
  Migraine is a common type of primary headache predominantly seen in women. This study aimed to evaluate endothelial function in patients with migraine using pulse wave velocity (PWV).
  
  
  METHODS
  The study included 73 patients with newly diagnosed migraine and 80 healthy subjects. All patients and controls underwent baseline transthoracic echocardiography and PWV measurements. Patients were randomized to three groups to receive propranolol, flunarizine or topiramate, and the measurements were repeated at the end of 1 month.
  
  
  RESULTS
  The newly diagnosed migraine patients and the control group exhibited no differences in baseline clinical characteristics, and the measurements showed that PWV was 7.4 ± 1.0 m/s in the patient group and 6.0 ± 1.0 m/s in the control group (p < 0.001). The same measurements were repeated during a control visit at the end of 1 month. Following treatment, a significant decrease was observed in PWV in all patient groups compared to baseline (p < 0.001). Subgroup analysis showed significantly decreased PWV in all drug groups, with the most prominent decrease in the topiramate group.
  
  
  CONCLUSIONS
  The increased PWV demonstrated in migraine patients in this study stands out as an additional parameter elucidating endothelial dysfunction in these patients. Decreasing the number of migraine attacks with prophylactic treatment may reduce PWV and decrease cardiovascular risk in long-term follow-up.
authors: Department of Cardiology, Erciyes University Medical Faculty , Kayseri , Turkey.
authors: Ali
authors: A
authors: Dogan
authors: Ozcan
authors: O
authors: Orscelik
authors: Merva
authors: M
authors: Kocyigit
authors: Deniz
authors: D
authors: Elcik
authors: Oguzhan
authors: O
authors: Baran
authors: Nebi
authors: N
authors: Cerit
authors: Mehmet Tugrul
authors: MT
authors: Inanc
authors: Nihat
authors: N
authors: Kalay
authors: Sevda
authors: S
authors: Ismailogullari
authors: Tolga
authors: T
authors: Saka
authors: Ibrahim
authors: I
authors: Ozdogru
authors: Abdurrahman
authors: A
authors: Oguzhan
authors: Namik Kemal
authors: NK
authors: Eryol
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D063177:Pulse Wave Analysis / Q000379:methods*; D012307:Risk Factors; D016896:Treatment Outcome; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult
keywords: arterial stiffness; endothelial dysfunction; migraine; prophylaxis