title: Bisbenzylisoquinoline alkaloids from the roots of cyclea tonkinensis.
abstract: Cissampentine A (1), an enantiomer of cissampentin, three new cycleatjehenine-type bisbenzylisoquinoline alkaloids, cissampentine B-D (2-4), and five known alkaloids were isolated from the roots of Cyclea tonkinensis. Their structures were established by interpretation of NMR, high-resolution ESI-MS data, and CD spectra. In vitro studies indicated that compounds 1 and 4 exhibited cytotoxicity against the HCT-8 tumor cell line (IC50 values of 8.97 and 9.73 µM, respectively), and compound 4 was also active against the Bel-7402 tumor cell line (IC50 value of 5.36 µM).
authors: West China College of Pharmacy, Sichuan University, Chengdu, P. R. China.
authors: Jian-Zhong
authors: JZ
authors: Wang
authors: West China College of Pharmacy, Sichuan University, Chengdu, P. R. China.
authors: Jing
authors: J
authors: Liao
authors: West China College of Pharmacy, Sichuan University, Chengdu, P. R. China.
authors: Wen-Long
authors: WL
authors: Xu
authors: West China College of Pharmacy, Sichuan University, Chengdu, P. R. China.
authors: Xiao-Bing
authors: XB
authors: Chen
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D044182:Benzylisoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D031604:Cyclea / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D044182:Benzylisoquinolines; D010936:Plant Extracts; C000604986:cissampentin; C000604987:cissampentine D