title: Vacuum-induced Suction Stimulates Increased Numbers of Blood Vessels in Healthy Dog Gingiva.
abstract: ﻿﻿﻿﻿﻿﻿ This study was designed to determine if vacuum-induced suction increased the number of blood vessels in healthy dog gingiva as a prelude to future studies testing vacuum therapy for improving local blood supply and controlling periodontal disease.
  
  
  METHODS
  The buccal gingiva of five dogs was treated with subatmospheric pressure for 5 days, with untreated tissues acting as controls. Biopsies were analyzed for vascular endothelial growth factors (VEGF) and blood vessels were counted.
  
  
  RESULTS
  VEGF and vessel numbers were elevated in treatment groups compared to controls (P < 0.05).
  
  
  CONCLUSIONS
  A single daily application of subatmospheric pressure might be beneficial for healing damaged or diseased gingival tissues. ﻿﻿﻿.
authors: ﻿Department of Diagnostic Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX; email: obudinskaya@bcd.tamhsc.edu.
authors: Oksana V
authors: OV
authors: Budinskaya
authors: Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX.
authors: Elias D
authors: ED
authors: Kontogiorgos
authors: Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX.
authors: Meredith
authors: M
authors: Brownlee
authors: Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX.
authors: Jennifer S
authors: JS
authors: Lee
authors: 3Departments of Biochemistry and Petroleum Engineering, Texas Tech University, Lubbock, TX.
authors: Roman A
authors: RA
authors: Budinskiy
authors: Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX.
authors: Paul C
authors: PC
authors: Dechow
authors: Department of Diagnostic Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX.
authors: John M
authors: JM
authors: Wright
authors: Departments of Biochemistry and Petroleum Engineering, Texas Tech University, Lubbock, TX.
authors: Kathy K H
authors: KK
authors: Svoboda
authors: Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX.
authors: Lynne A
authors: LA
authors: Opperman