title: Relationship between the concentrations of heavy metals and bioelements in aging men with metabolic syndrome.
abstract: Heavy metals may exacerbate metabolic syndrome (MS) but abnormal serum concentrations of bioelements may also co-exist with MS. The primary aim of the study was to assess the relationship of blood heavy metal and bioelement concentrations and MS, in men aged 50-75 years. Heavy metals-lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), tungsten (W), Macroelements-magnesium (Mg) and calcium (Ca), and microelements-iron (Fe), zinc (Zn) copper (Cu), chromium (Cr), molybdenum (Mo), selenium (Se) and manganese (Mn), body mass index (BMI), waist to hip ratio (WHR), abdominal circumference (AC) and blood pressure (BP), total cholesterol (TCh), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride (TG), fasting plasma glucose (FPG), insulin, and Homeostasis Model Assessment-Insulin resistance (HOMA-IR). The men with MS showed statistically significant higher Zn and lower Mg concentrations. Those with diabetes had higher Ca concentration and lower Mg concentration. Cr and Mn concentrations were significantly higher in obese men. The participants with hypertension had lower Mg concentration. We found statistically significant positive correlations (W-TCh, W-LDL, Mg-TCh, Mg-LDL, Ca-TCh, Ca-LDL, Ca-insulin, Ca-HOMAR-IR, Zn-TG, Zn-insulin, Zn-HOMA-IR, Cu-BP systolic, Mn-BMI, Mn-AC, Mn-WHR, Mn-insulin, Mn-HOMA-IR, Se-TCh, Se-LDL, Se-TG, Se-insulin, Se-HOMA-IR, Cr-TCh, Cr-HDL, Cr-LDL, Cr-TG) and negative correlations (Cd-insulin, Hg-WHR, W-insulin, W-HOMA-IR, Mg-BMI, Mg-AC, Mg-WHR, Mg-BP systolic, Mo-insulin, Mn-HDL). Tungsten may contribute to lipid disorders. Magnesium appears to play the protective role in the occurrence of metabolic disorders. Microelements Mn, Cr and Se may intensify MS.
authors: Independent Laboratory of Medical Rehabilitation, Pomeranian Medical University, Żołnierska 54, 71-210 Szczecin, Poland. iwrot@wp.pl.
authors: Iwona
authors: I
authors: Rotter
authors: Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland. kodan@pum.edu.pl.
authors: Danuta
authors: D
authors: Kosik-Bogacka
authors: Department of Laboratory Diagnostics, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland. barbara.dolegowska@pum.edu.pl.|Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Szamarzewskiego 82/84, 60-569 Poznań, Poland. barbara.dolegowska@pum.edu.pl.
authors: Barbara
authors: B
authors: Dołęgowska
authors: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland. chrissaf@mp.pl.
authors: Krzysztof
authors: K
authors: Safranow
authors: Department of Physical Medicine and Functional Diagnostics, Pomeranian Medical University, Żołnierska 54, 71-210 Szczecin, Poland. annalubkowska@gmail.com.
authors: Anna
authors: A
authors: Lubkowska
authors: Department of Histology and Developmental Biology, Pomeranian Medical University, Żołnierska 48, 71-210 Szczecin, Poland. maria@laszczynska.pl.
authors: Maria
authors: M
authors: Laszczyńska
mesh_terms: D000368:Aged; D004781:Environmental Exposure; D006801:Humans; D008297:Male; D066192:Manufacturing Industry; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000453:epidemiology*; D019216:Metals, Heavy / Q000633:toxicity*; D008875:Middle Aged; D016273:Occupational Exposure; D011044:Poland / Q000453:epidemiology; D014131:Trace Elements / Q000633:toxicity*
chemical_list: D019216:Metals, Heavy; D014131:Trace Elements