title: Innovations in subcutaneous infusions.
abstract: Parenteral drug delivery is an essential part of patient care. The subcutaneous (SC) route is easily accessed, is more cost-effective, and provides increased convenience for the patient than the other parenteral methods. The pharmacokinetic profile of medications delivered SC reflect bioavailabilities similar to intravenous (IV) delivery. The coadministration of human recombinant hyaluronidase with SC medications enhances the maximum concentration and time to maximum concentration to more closely mimic drugs delivered by the IV route. Pharmaceutical companies are studying and successfully developing new formulations of current medications for delivery via the SC route.
authors: Department of Emergency Medicine, University of Oklahoma School of Community Medicine, Tulsa, Oklahoma. †Deceased. Annette O. Arthur, PharmD, was an assistant professor and research director in the Department of Emergency Medicine at the University of Oklahoma School of Community Medicine in Tulsa, Oklahoma. She had been a pharmacist for more than 20 years, the first 9 of which were in the home infusion industry.
authors: Annette O
authors: AO
authors: Arthur
mesh_terms: D004059:Diffusion of Innovation; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage* / Q000493:pharmacokinetics; D055104:Infusions, Subcutaneous / Q000451:nursing* / Q000639:trends*
chemical_list: D006821:Hyaluronoglucosaminidase