title: Synergic actions of polyphenols and cyanogens of peanut seed coat (Arachis hypogaea) on cytological, biochemical and functional changes in thyroid.
abstract: In animals, long-term feeding with peanut (Arachis hypogaea) seed coats causes hypertrophy and hyperplasia of the thyroid gland. However, to date there have been no detailed studies. Here, we explored the thyroidal effects of dietary peanut seed coats (PSC) in rats. The PSC has high levels of pro-goitrogenic substances including phenolic and other cyanogenic constituents. The PSC was mixed with a standard diet and fed to rats for 30 and 60 days, respectively. Animals fed with the PSC-supplemented diet showed a significant increase in urinary excretion of thiocyanate and iodine, thyroid enlargement, and hypertrophy and/or hyperplasia of thyroid follicles. In addition, there was inhibition of thyroid peroxidase (TPO) activity, 5'-deiodinase-I (DIO1) activity, and (Na+-K+)-ATPase activity in the experimental groups of rats as compared to controls. Furthermore, the PSC fed animals exhibited decreased serum circulating total T4 and T3 levels, severe in the group treated for longer duration. These data indicate that PSC could be a novel disruptor of thyroid function, due to synergistic actions of phenolic as well as cyanogenic constituents.
authors: Amar K
authors: AK
authors: Chandra
authors: Chiranjit
authors: C
authors: Mondal
authors: Sabyasachi
authors: S
authors: Sinha
authors: Arijit
authors: A
authors: Chakraborty
authors: Elizabeth N
authors: EN
authors: Pearce
mesh_terms: D000821:Animal Feed / Q000009:adverse effects*; D000818:Animals; D013956:Antithyroid Agents / Q000302:isolation & purification / Q000633:toxicity*; D010367:Arachis / Q000737:chemistry*; D004357:Drug Synergism; D005960:Glucosides / Q000032:analysis / Q000494:pharmacology / Q000633:toxicity*; D006965:Hyperplasia; D006984:Hypertrophy; D007037:Hypothyroidism / Q000097:blood / Q000139:chemically induced* / Q000652:urine; D007453:Iodide Peroxidase / Q000037:antagonists & inhibitors; D007455:Iodine / Q000652:urine; D008297:Male; D009570:Nitriles / Q000032:analysis / Q000494:pharmacology / Q000633:toxicity*; D056771:Ovule / Q000737:chemistry*; D059808:Polyphenols / Q000032:analysis / Q000494:pharmacology / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors; D013861:Thiocyanates / Q000652:urine; D013961:Thyroid Gland / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013956:Antithyroid Agents; D005960:Glucosides; D009570:Nitriles; D059808:Polyphenols; D013861:Thiocyanates; D013963:Thyroid Hormones; C011206:cyanogen; D007455:Iodine; D007453:Iodide Peroxidase; D000254:Sodium-Potassium-Exchanging ATPase; C031760:thiocyanate