title: Liver Stiffness: A Significant Relationship with the Waveform Pattern in the Hepatic Vein.
abstract: The aim of this prospective study was to assess the relationship between liver stiffness and hepatic vein waveform patterns in 42 patients with chronic hepatitis and 55 with cirrhosis. Liver stiffness measurement (LSM) values (FibroScan, Echosens, Paris, France) were significantly lower in the triphasic pattern group (11.3 ± 8.4 kPa) than in the monophasic pattern (32.5 ± 23.5 kPa, p = 0.001) and biphasic pattern (25.6 ± 18.1 kPa, p = 0.001) groups, indicating no significant relationship with portal pressure. The ability to diagnose cirrhosis represented by the highest area under the receiver operating characteristic curve was 0.921 (83.6% sensitivity, 90.5% specificity, best cutoff value: 16.9 kPa) by LSM and 1.000 (best cutoff value: 19.4 kPa) by LSM combined with the monophasic pattern. This study revealed a close linkage between liver stiffness and hepatic vein waveform findings, resulting in a better understanding of hepatic vein hemodynamics and wider application of its analysis.
authors: Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuou-ku, Chiba, Japan.
authors: Tadashi
authors: T
authors: Sekimoto
authors: Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuou-ku, Chiba, Japan. Electronic address: maru-cib@umin.ac.jp.
authors: Hitoshi
authors: H
authors: Maruyama
authors: Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuou-ku, Chiba, Japan.
authors: Soichiro
authors: S
authors: Kiyono
authors: Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuou-ku, Chiba, Japan.
authors: Takayuki
authors: T
authors: Kondo
authors: Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuou-ku, Chiba, Japan.
authors: Taro
authors: T
authors: Shimada
authors: Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuou-ku, Chiba, Japan.
authors: Masanori
authors: M
authors: Takahashi
authors: Department of Gastroenterology and Nephrology, Chiba University Graduate School of Medicine, Chuou-ku, Chiba, Japan.
authors: Osamu
authors: O
authors: Yokosuka
authors: Department of Research Center for Frontier Medical Engineering, Chiba University, Inage-ku, Chiba, Japan.
authors: Tadashi
authors: T
authors: Yamaguchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods; D058625:End Stage Liver Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006503:Hepatic Veins / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008099:Liver / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008102:Liver Circulation; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler / Q000379:methods*
keywords: Cirrhosis; Hepatic vein waveform; Liver stiffness; Portal hypertension