title: Targeted images of KB cells using folate-conjugated gold nanoparticles.
abstract: Mercaptosuccinic acid-coated gold (GM) nanoparticles were prepared and characterized by transmission electron microscopy and dynamic light scattering. Folic acid (F) was then conjugated to the GM to preferentially target oral squamous cancer (KB) cells with folate receptors expressed on their membranes and facilitate the transit of the nanoparticles across the cell membrane. Finally, a fluorescence dye (Atto) was conjugated to the nanoparticles to visualize their internalization into KB cells. After culture of the cells in a medium containing GM and folate-conjugated GM (GF), the interaction of surface-modified gold nanoparticles with KB cells was studied.
authors: School of Applied Chemical Engineering, Graduate School, Kyungpook National University, 80, Daehak-ro, Buk-gu, Daegu 702-701 South Korea.
authors: Pierson
authors: P
authors: Rathinaraj
authors: School of Applied Chemical Engineering, Graduate School, Kyungpook National University, 80, Daehak-ro, Buk-gu, Daegu 702-701 South Korea.
authors: Kyubae
authors: K
authors: Lee
authors: School of Applied Chemical Engineering, Graduate School, Kyungpook National University, 80, Daehak-ro, Buk-gu, Daegu 702-701 South Korea.
authors: Soo-Young
authors: SY
authors: Park
authors: School of Applied Chemical Engineering, Graduate School, Kyungpook National University, 80, Daehak-ro, Buk-gu, Daegu 702-701 South Korea.
authors: Inn-Kyu
authors: IK
authors: Kang
keywords: Folic acid; Gold nanoparticles; Intracellular uptake; KB cells