title: Diffuse neonatal hemangiomatosis in a very low-birthweight infant treated with erythropoietin.
abstract: Diffuse neonatal hemangiomatosis (DNH) is a rare condition characterized by the concomitant development of multiple cutaneous infantile hemangiomas (IH) and visceral hemangiomas. Recently, an association between erythropoietin treatment and an increased incidence of infantile hemangioma was noted. A Japanese male infant was born via cesarean section at 27 weeks of gestation. Following the commencement of erythropoietin treatment for anemia of prematurity, he developed multiple cutaneous hemangiomas, high cardiac output heart failure and hepatomegaly. Abdominal imaging indicated comorbidity of diffuse infantile hepatic hemannigomas, resulting in the final diagnosis of DNH. The discontinuation of erythropoietin treatment and long-term therapy with propranolol improved the hepatic lesions and cutaneous hemangiomas. The possibility of multiple organ involvement and the exacerbating effects of erythropoietin treatment should be considered in cases in which multiple cutaneous hemangiomas develop in preterm infants receiving erythropoietin treatment.
authors: Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors: Takashi
authors: T
authors: Okuno
authors: Shuko
authors: S
authors: Tokuriki
authors: Tomomi
authors: T
authors: Yoshino
authors: Nanae
authors: N
authors: Tanaka
authors: Yusei
authors: Y
authors: Ohshima
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000751:Anemia, Neonatal / Q000188:drug therapy; D004921:Erythropoietin / Q000009:adverse effects*; D005865:Gestational Age; D006391:Hemangioma / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D007593:Joint Instability / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D010688:Phimosis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D011433:Propranolol / Q000627:therapeutic use; D012868:Skin Abnormalities / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000319:Adrenergic beta-Antagonists; D004921:Erythropoietin; D011433:Propranolol
keywords: diffuse neonatal hemangiomatosis; erythropoietin; hemangioma; propranolol; very low-birthweight infant