title: [Study of the influence of nodal liquefaction in measurement of the ADC value of OSCC metastatic lymph nodes in patients with oral squamous cell carcinoma].
abstract: OBJECTIVE
  To study the influence of nodal liquefaction portion in the measurement of the ADC value of metastatic lymph nodes in patients with oral squamous cell carcinoma (OSCC) on DW-MRI images.
  
  
  METHODS
  According to the postoperative histopathological examination results, the DW-MRI data of 25 OSCC patients was analyzed. The ADC values of both solid portions of metastatic lymph nodes and the whole metastatic lymph nodes with internal liquefaction were selected and measured. Further comparison between the 2 groups was processed for 2 independent samples t test with SPSS 17.0 software package.
  
  
  RESULTS
  Eleven patients out of all cases were diagnosed with cervical lymph node metastasis, and 15 metastatic lymph nodes were detected, among which 8 metastatic lymph nodes had obvious internal liquefaction. The average ADC values of solid portions of metastatic lymph nodes (group SMLN) and the whole metastatic lymph nodes with internal liquefaction (LMLN group) ADC were (872.1 ± 22.65) × 10⁻⁶ mm²/s (n=15) and (1073 ± 16.99) × 10⁻⁶ mm²/s (n=8), respectively. Two independent samples t test showed statistically significant difference of ADC values between group SMLN and group LMLN (P<0.05).
  
  
  CONCLUSIONS
  The internal liquefaction in OSCC metastatic lymph nodes can lead to an increased average ADC value. If the measurement of OSCC metastatic lymph nodes includes obvious liquefaction portions, it may reduce the diagnostic accuracy of DW-MRI for discrimination of lymph node metastasis.
authors: Department of Oral and Craniomaxillofacial Science, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology. Shanghai 200011;China.E-mail:dentarsjw@gmail.com.
authors: Jia-Wen
authors: JW
authors: Si
authors: Qi-Fan
authors: QF
authors: Hu
authors: Sheng-Yun
authors: SY
authors: Huang
authors: Hu-Wei
authors: HW
authors: Zou
authors: Jun
authors: J
authors: Shi
authors: Dong-Sheng
authors: DS
authors: Zhang
authors: Guo-Fang
authors: GF
authors: Shen
mesh_terms: D002294:Carcinoma, Squamous Cell; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms; D009333:Neck; D012680:Sensitivity and Specificity