title: [Langerhans cell histiocytosis of the stomach with BRAF-V600E-mutation: case report and review of the literature].
abstract: Langerhans cell histiocytosis is a disease with different clinical presentations and a wide spectrum of organ involvements. Rarely Langerhans cell histiocytosis can involve the gastrointestinal tract of adult patients. A case of infiltration of gastric mucosa by Langerhans cell histiocytosis is presented. The neoplastic nature of this infiltrate is underlined by the detection of a BRAF-V600E-mutation. Additionally, an overview of the so far 5 cases published in the English literature is provided. The published clinical experience indicates a benign curse of the disease.
authors: Pathologie München-Nord, München.
authors: M
authors: M
authors: Sarbia
authors: Innere Medizin, Krankenhaus Barmherzige Brüder München.
authors: R
authors: R
authors: Mauerer
authors: Teilgemeinschaftspraxis Molekularpathologie Südbayern, München.
authors: M
authors: M
authors: Bettstetter
authors: Pathologie München-Nord, München.
authors: A
authors: A
authors: Funk
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D013272:Stomach Diseases / Q000175:diagnosis* / Q000235:genetics*
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf