title: [Coumarins from Leonurus japonicus and their anti-platelet aggregative activity].
abstract: Chemical constituents of Leonurus japonicus were isolated and purified by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18. Structures of the isolates were determined by spectroscopic analysis as 10 coumarins: bergapten (1), xanthotoxin (2), isopimpinellin (3), isogosferal (4), imperatorin (5), meransin hydrate(6), isomeranzin(7), murrayone(8) , auraptenol(9), and osthol(10). In addition to compound 9, the others were isolated from the genus Leonurus for the first time. In the in vitro assay, compounds 4 and 8 significantly inhibited the abnormal increase of platelet aggregation induced by ADP.
authors: Huai
authors: H
authors: Yang
authors: Qin-mei
authors: QM
authors: Zhou
authors: Cheng
authors: C
authors: Peng
authors: Lu-si
authors: LS
authors: Liu
authors: Xiao-fang
authors: XF
authors: Xie
authors: Liang
authors: L
authors: Xiong
authors: Zhao-hua
authors: ZH
authors: Liu
mesh_terms: D001792:Blood Platelets / Q000187:drug effects*; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D031332:Leonurus / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D003374:Coumarins; D010975:Platelet Aggregation Inhibitors