title: Antibody escape kinetics of equine infectious anemia virus infection of horses.
abstract: Lentivirus escape from neutralizing antibodies (NAbs) is not well understood. In this work, we quantified antibody escape of a lentivirus, using antibody escape data from horses infected with equine infectious anemia virus. We calculated antibody blocking rates of wild-type virus, fitness costs of mutant virus, and growth rates of both viruses. These quantitative kinetic estimates of antibody escape are important for understanding lentiviral control by antibody neutralization and in developing NAb-eliciting vaccine strategies.
authors: School of Biological Sciences and Department of Mathematics, Washington State University, Pullman, Washington, USA ejs@wsu.edu nanda@math.tifrbng.res.in.
authors: Elissa J
authors: EJ
authors: Schwartz
authors: Centre for Applicable Mathematics, Tata Institute of Fundamental Research, Bangalore, India ejs@wsu.edu nanda@math.tifrbng.res.in.
authors: Seema
authors: S
authors: Nanda
authors: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
authors: Robert H
authors: RH
authors: Mealey
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D004859:Equine Infectious Anemia / Q000276:immunology* / Q000821:virology*; D006736:Horses; D057131:Immune Evasion; D004860:Infectious Anemia Virus, Equine / Q000235:genetics / Q000254:growth & development / Q000276:immunology*; D008962:Models, Theoretical; D009154:Mutation
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral