title: Gender and plasma iron biomarkers, but not HFE gene mutations, increase the risk of colorectal cancer and polyps.
abstract: A cohort study of patients included in the Basque Country colorectal cancer (CRC) screening programme was carried out to assess the risk of adenomatous polyps and CRC (P-CRC) associated with HFE gene mutations, with gender and with iron biomarkers (serum ferritin (SF), iron (Fe) and transferrin saturation index (TSI)). Among 432 included patients (mean age 59.8 years), 263 were men (60.9 %) and 169 women (39.1 %). P-CRC were identified in 221 patients (51.2 %) and no polyps (NP) in 211 patients (48.8 %). HFE mutations were identified in 43.8 % of the patients. C282Y/wt genotypic frequency was 6.8 % in the P-CRC group and 1.4 % in the NP group (p < 0.05). The allelic frequency was 3.8 versus 1.2 % (p < 0.05). For laboratory, all three iron biomarkers showed a statistically significant difference: mean Fe, 91.29 ± 34 for P-CRC and 80.81 ± 30.59 for NP group. Mean TSI for P-CRC was 24.95 ± 8.90 and 22.74 ± 8.79 for NP group. Mean SF 308.09 ± 536.32 for P-CRC and 177.55 ± 159.95 for NP group. In a multivariate logistic regression analysis, only male gender (odds ratio (OR) = 2.04, 1.29-3.22), SF (OR = 1.001, 1.0004-1.003) and Fe (OR = 1.01, 1.004-1.02) were related with the presence of CRC and adenoma. Men gender and raised serum iron biomarkers increase the risk of P-CRC.
authors: Mendaro Hospital, 20850, Mendaro, Basque Country, Spain. agustincastiella@yahoo.es.
authors: Agustin
authors: A
authors: Castiella
authors: Donostia University Hospital, Donostia, Spain.
authors: Fernando
authors: F
authors: Múgica
authors: Mendaro Hospital, 20850, Mendaro, Basque Country, Spain.
authors: Eva
authors: E
authors: Zapata
authors: Mendaro Hospital, 20850, Mendaro, Basque Country, Spain.
authors: Leire
authors: L
authors: Zubiaurre
authors: Mendaro Hospital, 20850, Mendaro, Basque Country, Spain.
authors: Arantxa
authors: A
authors: Iribarren
authors: Donostia University Hospital, Donostia, Spain.
authors: M Dolores
authors: MD
authors: de Juan
authors: Donostia University Hospital, Donostia, Spain.
authors: Luis
authors: L
authors: Alzate
authors: Donostia University Hospital, Donostia, Spain.
authors: Ines
authors: I
authors: Gil
authors: Donostia University Hospital, Donostia, Spain.
authors: Gregorio
authors: G
authors: Urdapilleta
authors: Mondragon Hospital, Mondragon, Spain.
authors: Pedro
authors: P
authors: Otazua
authors: Clinical Epidemiology Unit, Donostia University Hospital, CASPe, CIBER-ESP, Biodonostia, Donostia, Spain.
authors: José Ignacio
authors: JI
authors: Emparanza
mesh_terms: D018256:Adenomatous Polyps / Q000097:blood / Q000235:genetics / Q000473:pathology; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D004724:Endoscopy; D005260:Female; D005293:Ferritins / Q000097:blood; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D012727:Sex Characteristics
chemical_list: D014408:Biomarkers, Tumor; C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D005293:Ferritins; D007501:Iron
keywords: Colorectal cancer; Ferritin; HFE gene; Hemochromatosis; Iron biomarkers