title: Lactobacilli vaginal colonisation after oral consumption of Respecta(®) complex: a randomised controlled pilot study.
abstract: OBJECTIVE
  The aim of the current pilot study was to determine if oral consumption of a combination of two probiotics; L. acidophilus La-14, L. rhamnosus HN001, and bovine lactoferrin (Respecta(®) complex), would lead to the detection with molecular techniques of the consumed probiotic strains in the vagina.
  
  
  METHODS
  Healthy volunteers (40) consumed the study product twice daily for 2 weeks. Vaginal swabs were collected at 0, 1, 2 and 3 weeks and analysed for the consumed organisms by qPCR.
  
  
  RESULTS
  Vaginal L. rhamnosus and L. acidophilus levels were significantly increased on days 14 and 21. On days 14 and 21 a significant number of women had increased levels of vaginal L. acidophilus and on days 7 and 21 a significant number of women had increased levels of vaginal L. rhamnosus.
  
  
  CONCLUSIONS
  Consumption of L. acidophilus La-14, L. rhamnosus HN001 in combination with bovine lactoferrin leads to vaginal detection; even 1 week after consumption was stopped. This provides a basis for future studies on urogenital tract health.
authors: Struttura complessa ostetricia e ginecologia, Ospedale SS. Antonio e Biagio, Alessandria (AL), Italy.
authors: Davide
authors: D
authors: De Alberti
authors: Rosario
authors: R
authors: Russo
authors: Fabio
authors: F
authors: Terruzzi
authors: Vincenzo
authors: V
authors: Nobile
authors: Arthur C
authors: AC
authors: Ouwehand
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002417:Cattle; D015169:Colony Count, Microbial; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*; D007779:Lactobacillus acidophilus / Q000235:genetics / Q000302:isolation & purification; D052201:Lacticaseibacillus rhamnosus / Q000235:genetics / Q000302:isolation & purification; D007781:Lactoferrin / Q000008:administration & dosage*; D010865:Pilot Projects; D016133:Polymerase Chain Reaction; D019936:Probiotics / Q000008:administration & dosage*; D014621:Vagina / Q000382:microbiology*; D014626:Vaginal Smears / Q000379:methods
chemical_list: D000890:Anti-Infective Agents; D007781:Lactoferrin