title: Platelet-to-Lymphocyte Ratio Predicts Contrast-Induced Nephropathy in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome.
abstract: We assessed the relation between platelet-to-lymphocyte ratio (PLR) on admission and contrast-induced nephropathy (CIN) in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). A total of 488 patients with NSTE-ACS who underwent urgent coronary angiography were enrolled. Levels of PLR and creatinine were measured before angiography and at 72 hours after angiography. Patients were divided into 2 groups, namely, the CIN group, 80 patients (16.3%; age 65.3 ± 12.5years; 66.7% men) and the non-CIN group, 408 patients (83.7%; age 61.2 ± 12.3 years; 72.5% men). Patients in the CIN group had significantly higher PLR than those in the non-CIN group (152.9 ± 99.6 vs 120.4 ± 66.1, P < .001). In logistic regression analysis, PLR (odds ratio [OR] 1.004, 95% confidence interval [CI] 1.001-1.007, P = .02), diabetes mellitus (OR 1.75, 95% CI 1.02-2.98, P = .03), and ST-segment depression on admission electrocardiogram (OR 1.68, 95% CI 1.00-2.81, P = .04) were independent predictors of CIN. The PLR was an independent predictor of CIN after angiography in patients with NSTE-ACS.
authors: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors: Cuneyt
authors: C
authors: Kocas
authors: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey drayildiz@yahoo.com.
authors: Ahmet
authors: A
authors: Yildiz
authors: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors: Okay
authors: O
authors: Abaci
authors: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors: Osman Sukru
authors: OS
authors: Karaca
authors: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors: Nur
authors: N
authors: Firdin
authors: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors: Yalcin
authors: Y
authors: Dalgic
authors: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors: Cem
authors: C
authors: Bostan
authors: Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors: Murat
authors: M
authors: Ersanli
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets; D016009:Chi-Square Distribution; D015897:Comorbidity; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D016015:Logistic Models; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D010976:Platelet Count; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D003404:Creatinine
keywords: acute coronary syndrome; contrast-induced nephropathy; platelet-to-lymphocyte ratio