title: Bidens pilosa Formulation Improves Blood Homeostasis and β -Cell Function in Men: A Pilot Study.
abstract: B. pilosa has long been purported to have antidiabetes activity, but despite the advancement in phytochemistry and animal models of diabetes, no human clinical trials have been conducted to date. Here, we evaluated the effect of a B. pilosa formulation on fasting blood glucose (FBG), fasting serum insulin, and glycosylated hemoglobin A1c (HbA1c) in diabetic subjects. The B. pilosa formulation reduced the level of FBG and HbA1c in diabetics but increased fasting serum insulin in healthy subjects. Moreover, combination of B. pilosa formulation with antidiabetic drugs had better glycemic control in diabetics. The homeostatic model assessment (HOMA) data suggested that the antidiabetic activity of this formulation was via improvement of β-cell function. We also tested the safety of the B. pilosa formulation in healthy subjects and observed no obvious side effects. We conclude that B. pilosa has potential as an antidiabetes treatment.
authors: Chun-Yueh Biomedical Technology Co., Ltd., Taipei 116, Taiwan.
authors: Bun-Yueh
authors: BY
authors: Lai
authors: Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan ; Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan.
authors: Tzung-Yan
authors: TY
authors: Chen
authors: Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan ; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan.
authors: Shou-Hsien
authors: 0000-0002-0875-6588
authors: SH
authors: Huang
authors: Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan.
authors: Tien-Fen
authors: 0000-0002-9406-9134
authors: TF
authors: Kuo
authors: Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan ; Department of Cancer Biology and Medicine, China Medical University, Taichung 404, Taiwan.
authors: Ting-Hsiang
authors: TH
authors: Chang
authors: Department of Chinese Medicine, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan.
authors: Chih-Kang
authors: CK
authors: Chiang
authors: Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan.
authors: Meng-Ting
authors: MT
authors: Yang
authors: Department of Veterinary Medicine, National Chung Hsing University, 250 Kuo-Kuang Road, Taichung 402, Taiwan.
authors: Cicero Lee-Tian
authors: CL
authors: Chang