title: No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder.
abstract: Stress is an important risk factor in the etiology of psychotic disorder. Preclinical work has shown that stress primarily increases dopamine (DA) transmission in the frontal cortex. Given that DA-mediated hypofrontality is hypothesized to be a cardinal feature of psychotic disorder, stress-related extrastriatal DA release may be altered in psychotic disorder. Here we quantified for the first time stress-induced extrastriatal DA release and the spatial extent of extrastriatal DA release in individuals with non-affective psychotic disorder (NAPD). Twelve healthy volunteers (HV) and 12 matched drug-free NAPD patients underwent a single infusion [(18)F]fallypride positron emission tomography scan during which they completed the control and stress condition of the Montreal Imaging Stress Task. HV and NAPD did not differ in stress-induced [(18)F]fallypride displacement and the spatial extent of stress-induced [(18)F]fallypride displacement in medial prefrontal cortex (mPFC) and temporal cortex (TC). In the whole sample, the spatial extent of stress-induced radioligand displacement in right ventro-mPFC, but not dorso-mPFC or TC, was positively associated with task-induced subjective stress. Psychotic symptoms during the scan or negative, positive and general subscales of the Positive and Negative Syndrome Scale were not associated with stress-induced [(18)F]fallypride displacement nor the spatial extent of stress-induced [(18)F]fallypride displacement in NAPD. Our results do not offer evidence for altered stress-induced extrastriatal DA signaling in NAPD, nor altered functional relevance. The implications of these findings for the role of the DA system in NAPD and stress processing are discussed.
authors: Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands.
authors: D
authors: D
authors: Hernaus
authors: Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands.
authors: D
authors: D
authors: Collip
authors: Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands.
authors: Z
authors: Z
authors: Kasanova
authors: Department of Nuclear Medicine, University Hospital RWTH Aachen University, Aachen, Germany.
authors: O
authors: O
authors: Winz
authors: Department of Nuclear Medicine, University Hospital RWTH Aachen University, Aachen, Germany.
authors: A
authors: A
authors: Heinzel
authors: 1] Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands [2] Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors: T
authors: T
authors: van Amelsvoort
authors: Department of Nuclear Medicine, University Hospital RWTH Aachen University, Aachen, Germany.
authors: S M
authors: SM
authors: Shali
authors: Department of Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands.
authors: J
authors: J
authors: Booij
authors: Department of Nuclear Medicine, University Hospital RWTH Aachen University, Aachen, Germany.
authors: Y
authors: Y
authors: Rong
authors: Institute of Nuclear Chemistry, Johannes Gutenberg University, Mainz, Germany.
authors: M
authors: M
authors: Piel
authors: Department of Psychiatry, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada.
authors: J
authors: J
authors: Pruessner
authors: 1] Department of Nuclear Medicine, University Hospital RWTH Aachen University, Aachen, Germany [2] Department of Nuclear Medicine, Maastricht University Hospital, Maastricht, The Netherlands.
authors: F M
authors: FM
authors: Mottaghy
authors: Department of Psychiatry and Psychology, South Limburg Mental Health Research and Teaching Network, EURON, School for Mental Health and NeuroScience MHeNS Maastricht University, Maastricht, The Netherlands.
authors: I
authors: I
authors: Myin-Germeys
mesh_terms: D000328:Adult; D001549:Benzamides; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D016022:Case-Control Studies; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D017072:Neostriatum; D049268:Positron-Emission Tomography; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000378:metabolism*; D013315:Stress, Psychological / Q000000981:diagnostic imaging / Q000378:metabolism*; D009435:Synaptic Transmission; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism*
chemical_list: D001549:Benzamides; D005462:Fluorine Radioisotopes; C574003:fallypride; D004298:Dopamine