title: Use of benzodiazepines and detoxification with methadone.
abstract: BACKGROUND
  Benzodiazepines are used as anti anxiety drugs, as well as in adjunct treatment for a range of neurological and psychiatric disorders. Abusive patterns of use were increasingly reported and building evidence points to prevalence of benzodiazepines abuse, on one hand as well as to their common abuse in combination with other drugs such as opioids, most frequently.
  
  
  OBJECTIVE
  The main objective of this research is to conduct a systematic study on the behavior profile of a patient admitted to a prison hospital, who is a benzodiazepines user consecutive to admission into a methadone administration program.
  
  
  RESULTS
  Statistic values have been taken into account describing the distribution and the distribution form of the various variables studied to find the normality degree of distributions, regarding three measurements at the three moments: before the administration of methadone, immediately after its completion and two months after completion.
  The statistic results obtained speak of a strong positive correlation, allowing the support of the fact that persons diagnosed with prescribed/ unprescribed benzodiazepine, use the display association with the admission into a methadone administration program, based on the assumption which concerns a significant positive association between the use of reported benzodiazepine and the administration of methadone in the questioned patients on admission. As far as the second premise regarding the administration of methadone is concerned it brings about an improvement in the level of benzodiazepines used in research patients, which one may assert that, according to the results obtained, the initiation of methadone therapy in the detoxification program is conducive to the reduction of benzodiazepines use.
authors: Department of Toxicology, "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest.
authors: G
authors: G
authors: Popescu
authors: Department of Toxicology, "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest.
authors: C
authors: C
authors: Negrei
authors: Department of Toxicology, "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest.
authors: D
authors: D
authors: Bălălău
authors: Department of Drug Control, "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest.
authors: A M
authors: AM
authors: Ciobanu
authors: Department of Toxicology, "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest.
authors: D
authors: D
authors: Baconi
authors: Department of Toxicology, "Carol Davila" University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest, ; "Sf. Pantelimon" Emergency Hospital, Surgical Clinic, "Carol Davila" University of Medicine and Pharmacy, Faculty of General Medicine.
authors: C
authors: C
authors: Bălălău
mesh_terms: D000293:Adolescent; D000328:Adult; D001569:Benzodiazepines / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D019966:Substance-Related Disorders / Q000188:drug therapy*
chemical_list: D001569:Benzodiazepines; D008691:Methadone
keywords: abuse; benzodiazepines; methadone