title: A surveillance study of intensity-modulated radiation therapy for postoperative cervical cancer in Japan.
abstract: Intensity-modulated radiation therapy (IMRT) was recently introduced to the field of gynecologic malignancies; however, its value is not yet validated. A clinical trial is in preparation to investigate the efficacy and feasibility of IMRT for postoperative cervical cancer. The object of this study was to perform a surveillance study of IMRT for post-operative cervical cancer. A questionnaire regarding the precise methods of conducting IMRT was sent to six institutions that had already introduced IMRT for post-operative cervical cancer, and the data were analyzed. Half of the institutions used static IMRT and the others used volumetric-modulated arc therapy (VMAT). Most institutions used body-immobilizing devices for patient fixation. Most institutions instructed patients to fill their bladder before undergoing planning CT or daily treatment. While one institution inserted metallic markers and another one used radio-contrast-soaked gauze to visualize the vaginal cuff, the other institutions used nothing for vaginal cuff visualization. Most institutions defined the clinical target volumes according to the Japan Clinical Oncology Group or the Radiation Therapy Oncology Group guidelines. Only one institution used a prescribed dose based on 95% of the PTV (D(95)), while the rest used the mean dose (D(mean)). This valuable information from six leading institutions will be utilized in a future prospective clinical trial.
authors: Department of Radiation Oncology, National Cancer Center Hospital, T5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan namuraka@ncc.go.jp.
authors: Naoya
authors: N
authors: Murakami
authors: Department of Radiation Oncology, National Cancer Center Hospital, T5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors: Hiroyuki
authors: H
authors: Okamoto
authors: Department of Radiation Oncology, Osaka University Hospital, Suita, Osaka.
authors: Fumiaki
authors: F
authors: Isohashi
authors: Department of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki.
authors: Keiko
authors: K
authors: Murofushi
authors: Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma.
authors: Tatsuya
authors: T
authors: Ohno
authors: Department of Radiology, Gunma Prefecture Cancer Center, Gunma.
authors: Daisaku
authors: D
authors: Yoshida
authors: Department of Radiation Oncology, Chiba Cancer Center, Chiba.
authors: Makoto
authors: M
authors: Saito
authors: Department of Radiation Oncology, National Cancer Center Hospital, T5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors: Koji
authors: K
authors: Inaba
authors: Department of Radiation Oncology, National Cancer Center Hospital, T5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors: Yoshinori
authors: Y
authors: Ito
authors: Department of Radiology, Graduate School of Medicine, University of Ryukyus, Okinawa.
authors: Takafumi
authors: T
authors: Toita
authors: Department of Radiation Oncology, National Cancer Center Hospital, T5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors: Jun
authors: J
authors: Itami
mesh_terms: D005260:Female; D019983:Guideline Adherence; D006801:Humans; D015907:Hysteroscopy / Q000592:standards / Q000706:statistics & numerical data*; D007564:Japan / Q000453:epidemiology; D056888:Patient Positioning / Q000592:standards / Q000706:statistics & numerical data*; D011182:Postoperative Care / Q000592:standards / Q000706:statistics & numerical data*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000592:standards / Q000706:statistics & numerical data; D015995:Prevalence; D018714:Radiotherapy, Adjuvant / Q000592:standards / Q000706:statistics & numerical data; D050397:Radiotherapy, Intensity-Modulated / Q000592:standards / Q000706:statistics & numerical data*; D012307:Risk Factors; D018571:Sentinel Surveillance; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000628:therapy*
keywords: Japan; cervical cancer; intensity-modulated radiation therapy; postoperative adjuvant radiation therapy; surveillance