title: Novel PET/SPECT probes for imaging of tau in Alzheimer's disease.
abstract: As the world's population ages, the number of patients with Alzheimer's disease (AD) is predicted to increase rapidly. The presence of neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau protein, is one of the neuropathological hallmarks of AD brain. Since the presence of NFTs is well correlated with neurodegeneration and cognitive decline in AD, imaging of tau using positron emission tomography (PET) and single-photon emission computed tomography (SPECT) is useful for presymptomatic diagnosis and monitoring of the progression of AD. Therefore, novel PET/SPECT probes for the imaging of tau have been developed. More recently, several probes were tested clinically and evaluated for their utility. This paper reviews the current state of research on the development and evaluation of PET/SPECT probes for the imaging of tau in AD brain.
authors: Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.
authors: Hiroyuki
authors: 0000-0002-8873-1224
authors: H
authors: Watanabe
authors: Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.
authors: Masahiro
authors: M
authors: Ono
authors: Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.
authors: Hideo
authors: 0000-0002-3077-9321
authors: H
authors: Saji
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D006801:Humans; D049268:Positron-Emission Tomography; D015899:Tomography, Emission-Computed, Single-Photon; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016875:tau Proteins