title: IKCa channels are a critical determinant of the slow AHP in CA1 pyramidal neurons.
abstract: Control over the frequency and pattern of neuronal spike discharge depends on Ca2+-gated K+ channels that reduce cell excitability by hyperpolarizing the membrane potential. The Ca2+-dependent slow afterhyperpolarization (sAHP) is one of the most prominent inhibitory responses in the brain, with sAHP amplitude linked to a host of circuit and behavioral functions, yet the channel that underlies the sAHP has defied identification for decades. Here, we show that intermediate-conductance Ca2+-dependent K+ (IKCa) channels underlie the sAHP generated by trains of synaptic input or postsynaptic stimuli in CA1 hippocampal pyramidal cells. These findings are significant in providing a molecular identity for the sAHP of central neurons that will identify pharmacological tools capable of potentially modifying the several behavioral or disease states associated with the sAHP.
authors: Brian
authors: B
authors: King
authors: Arsalan P
authors: AP
authors: Rizwan
authors: Hadhimulya
authors: H
authors: Asmara
authors: Norman C
authors: NC
authors: Heath
authors: Jordan D T
authors: JD
authors: Engbers
authors: Steven
authors: S
authors: Dykstra
authors: Theodore M
authors: TM
authors: Bartoletti
authors: Shahid
authors: S
authors: Hameed
authors: Gerald W
authors: GW
authors: Zamponi
authors: Ray W
authors: RW
authors: Turner
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D056547:CA1 Region, Hippocampal / Q000737:chemistry / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D006624:Hippocampus / Q000737:chemistry / Q000502:physiology; D051379:Mice; D009474:Neurons / Q000737:chemistry / Q000502:physiology*; D018408:Patch-Clamp Techniques; D024681:Potassium Channels, Calcium-Activated / Q000737:chemistry* / Q000378:metabolism; D017966:Pyramidal Cells / Q000737:chemistry / Q000502:physiology*
chemical_list: D024681:Potassium Channels, Calcium-Activated