title: Relationship Between Prohormone Brain Natriuretic Peptide (NT-proBNP) Level and Severity of Pulmonary Dysfunction in Patients With Chronic Congestive Heart Failure.
abstract: BACKGROUND
  Congestive heart failure (CHF) is a common disease and its prevalence is increasing in industrialized countries. NT-proBNP measurement is an established diagnostic test for diagnosis of CHF in patients who present to emergency room with acute dyspnea. The primary object of this study was to determine the relationship between levels of brain natriuretic peptide precursor and severity of lung function impairment in patients with chronic CHF.
  
  
  METHODS
  This cross-sectional and analytical study that performed in Tuberculosis and Lung Disease Research Center of Tabriz University of Medical Sciences on 95 patients with chronic heart failure, and relation between NT-proBNP levels and pulmonary function parameters were examined.
  
  
  RESULTS
  Sixty-four patients were male and 31 were female. The average age of male and females was 62.90 ± 11.54 and 61.61 ± 11.98 years, respectively. A significant inverse linear correlation was found between NT-proBNP and FEV1 (P < 0.001, r = -0.367), FVC (P < 0.001, r = -0.444), TLC (P = 0.022, r = -0.238), maximal midexpiratory flow (MMEF) (P = 0.047, r = -0.207) and left ventricular ejection fraction (LVEF) (P < 0.001, r = -0.461). A significant positive linear correlation was found between NT-proBNP and FEV1/FVC (P = 0.013, r = 0.257), RV/TLC (P = 0.003, r=0.303) and 5 Hz Raw (r = 0.231, P = 0.024).
  
  
  CONCLUSIONS
  This study showed that, both restrictive and obstructive ventilator impairments can occur in chronic CHF and as NT-proBNP increases appropriate to hemodynamic deterioration, pulmonary dysfunction increases.
authors: Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Masoud
authors: M
authors: Nazemiyeh
authors: Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Akbar
authors: A
authors: Sharifi
authors: Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Farhad
authors: F
authors: Amiran
authors: Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Leili
authors: L
authors: Pourafkari
authors: Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Mohammadreza
authors: M
authors: Taban Sadeghi
authors: Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Hossein
authors: H
authors: Namdar
authors: Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Mohsen
authors: M
authors: Abbasnezhad
keywords: Congestive Heart Failure; NT-proBNP; Oscillometry; Respiratory Function Tests