title: Systemic effects of locally injected platelet rich plasma in a rat model: an analysis on muscle and bloodstream.
abstract: Abundant evidence suggests that growth factors, contained in platelets alpha granules, may play a key role in the early stages of the muscle healing process with particular regard to the inflammatory phase. Although the contents of the platelet-rich plasma preparations have been extensively studied, the biological mechanisms involved as well as the systemic effects and the related potential doping implications of this approach are still largely unknown. The aim of the present study was to investigate whether local platelet-rich plasma administration may modify the levels of specific cytokines and growth factors both in treated muscle and bloodstream in rats. An additional aim was to investigate more deeply whether the local platelet-rich plasma administration may exert systemic effects by analyzing contralateral lesioned but untreated muscles. The results showed that platelet-rich plasma treatment induced a modification of certain cytokines and growth factor levels in muscle but not in the bloodstream, suggesting that local platelet-rich plasma treatment influenced directly or, more plausibly, indirectly the synthesis or recruitment of cytokines and growth factors at the site of injury. Moreover, the observed modifications of cytokine and growth factor levels in contralateral injured but not treated muscles, strongly suggested a systemic effect of locally injected platelet-rich plasma.
authors: Department of Movement, Human and Health Science, University of Rome Foro Italico, Rome, Italy.
authors: P
authors: P
authors: Borrione
authors: 1 Department of Movement, Human and Health Science, University of Rome Foro Italico, Rome, Italy.
authors: L
authors: L
authors: Grasso
authors: Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
authors: S
authors: S
authors: Racca
authors: Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
authors: G
authors: G
authors: Abbadessa
authors: Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
authors: V
authors: V
authors: Carriero
authors: Department of Movement, Human and Health Science, University of Rome Foro Italico, Rome, Italy.
authors: F
authors: F
authors: Fagnani
authors: Department of Movement, Human and Health Science, University of Rome Foro Italico, Rome, Italy.
authors: F
authors: F
authors: Quaranta
authors: Department of Movement, Human and Health Science, University of Rome Foro Italico, Rome, Italy.
authors: F
authors: F
authors: Pigozzi
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood*; D007267:Injections; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D018482:Muscle, Skeletal / Q000293:injuries* / Q000378:metabolism; D053657:Platelet-Rich Plasma; D017208:Rats, Wistar
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins