title: Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults.
abstract: The ability of a quadrivalent human papilloma virus (HPV)-16/18/6/11 virus-like particles vaccine (Gardasil) to elicit HPV-specific cell-mediated immune responses was evaluated in antiretroviral therapy (ART)-treated HIV-infected young adults. Results showed that, after three doses of vaccine, central memory and effector memory CD4(+) and CD8(+) T lymphocytes, as well as HPV-specific interleukin (IL)2(+)/CD4(+), interferon-gamma (IFN-γ(+))/CD4(+), IFN-γ(+)/CD8(+) and tumour necrosis factor-alpha (TNF-α)(+)/CD8(+) T lymphocytes and Perforin and Granzyme B secreting CD8(+) T lymphocytes were significantly increased. Notably, results obtained in HIV-infected patients were comparable to those seen in HIV-uninfected age-matched healthy controls.
authors: aDepartment of Biomedical and Clinical Sciences 'L. Sacco', University of Milan bDepartment of Pediatrics, University of Milan, L. Sacco Hospital cDepartment of Pediatrics, University of Milan, Ospedale dei Bambini V. Buzzi dDepartment of Physiopathology Medical-Surgery and Transplantation, University of Milan eDon C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy.
authors: Veronica
authors: V
authors: Rainone
authors: Vania
authors: V
authors: Giacomet
authors: Francesca
authors: F
authors: Penagini
authors: Valentina
authors: V
authors: Fabiano
authors: Francesca
authors: F
authors: Calascibetta
authors: Chiara
authors: C
authors: Mameli
authors: Stefania
authors: S
authors: Pisanelli
authors: Gian Vincenzo
authors: GV
authors: Zuccotti
authors: Mario
authors: M
authors: Clerici
authors: Daria
authors: D
authors: Trabattoni
mesh_terms: D000293:Adolescent; D016207:Cytokines / Q000378:metabolism; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 / Q000008:administration & dosage* / Q000276:immunology*; D052162:Human papillomavirus 16; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D008137:Longitudinal Studies; D030361:Papillomavirus Infections / Q000276:immunology / Q000517:prevention & control*; D011446:Prospective Studies; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014611:Vaccination / Q000379:methods*; D055815:Young Adult
chemical_list: D016207:Cytokines; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18