title: New reagent for highly efficient synthesis of trifluoromethyl-substituted arenes and heteroarenes.
abstract: A new reagent trimethylsilyl chlorodifluoroacetate (TCDA) is reported for the introduction of a -CF3 group to arenes and heteroarenes. Compared with current known reagents, TCDA shows very broad scope with respect to electron-deficient, -neutral, and -rich aryl/heteroaryl iodides as well as excellent functional group tolerance, including ester, amide, aldehyde, hydroxyl, and carboxylic acid.
authors: Neurodegeneration DPU, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, China.
authors: Xiaomin
authors: X
authors: Zhang
authors: Neurodegeneration DPU, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, China.
authors: Jian
authors: J
authors: Wang
authors: Neurodegeneration DPU, GlaxoSmithKline, 898 Halei Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, China.
authors: Zehong
authors: Z
authors: Wan