title: Phenylboronic acid-based (19)F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical-shift change.
abstract: Herein, we report on a new (19)F MRI probe for the detection and imaging of H2O2. Our designed 2-fluorophenylboronic acid-based (19)F probe promptly reacted with H2O2 to produce 2-fluorophenol via boronic acid oxidation. The accompanying (19)F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H2O2 by (19)F chemical-shift-selective MRI.
authors: INAMORI Frontier Research Center, Kyushu University.
authors: Hiroshi
authors: H
authors: Nonaka
authors: Qi
authors: Q
authors: An
authors: Fuminori
authors: F
authors: Sugihara
authors: Tomohiro
authors: T
authors: Doura
authors: Akira
authors: A
authors: Tsuchiya
authors: Yoshichika
authors: Y
authors: Yoshioka
authors: Shinsuke
authors: S
authors: Sando
mesh_terms: D001897:Boronic Acids; D066235:Fluorine-19 Magnetic Resonance Imaging / Q000379:methods*; D006861:Hydrogen Peroxide / Q000032:analysis* / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D006861:Hydrogen Peroxide; C010686:benzeneboronic acid