title: High frequency stimulation of the STN restored the abnormal high-voltage spindles in the cortex and the globus pallidus of 6-OHDA lesioned rats.
abstract: Many studies showed that abnormal oscillations in the cortical-basal ganglia loop is involved in the pathophysiology of Parkinson's disease (PD). In contrast to the well-studied beta synchronization, high-voltage spindles (HVSs), another type of abnormal oscillation observed in PD, are neglected. To explore the role of subthalamic nucleus-deep brain stimulation (STN-DBS) in HVSs regulation, we simultaneously recorded the local field potential (LFP) in the globus pallidus (GP) and electrocorticogram (ECoG) in the primary motor cortex(M1) in freely moving 6-hydroxydopamine (6-OHDA) lesioned or control rats before, during, and after STN-DBS. Consistent with our previous study, HVSs occurrence, duration, and relative power and coherence between the M1 cortex and GP increased in 6-OHDA lesioned rats. We found that high but not low frequency stimulation restored the abnormal HVSs activity and motor deficit. These results suggest that the STN is involved in the abnormal oscillation between the M1 cortex and GP.
authors: Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
authors: Chen
authors: C
authors: Yang
authors: Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
authors: Jia-Rui
authors: JR
authors: Zhang
authors: Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
authors: Lei
authors: L
authors: Chen
authors: Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
authors: Shun-Nan
authors: SN
authors: Ge
authors: Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
authors: Jue-Lei
authors: JL
authors: Wang
authors: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
authors: Zhi-Qiang
authors: ZQ
authors: Yan
authors: Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China.
authors: Dong
authors: D
authors: Jia
authors: Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China. Electronic address: zhujl65@fmmu.edu.cn.
authors: Jun-Ling
authors: JL
authors: Zhu
authors: Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, People's Republic of China. Electronic address: tdgguodong@163.com.
authors: Guo-Dong
authors: GD
authors: Gao
mesh_terms: D000818:Animals; D046690:Deep Brain Stimulation; D004298:Dopamine / Q000378:metabolism; D005917:Globus Pallidus / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009044:Motor Cortex / Q000187:drug effects* / Q000503:physiopathology; D016627:Oxidopamine / Q000633:toxicity*; D017207:Rats, Sprague-Dawley; D020531:Subthalamic Nucleus / Q000187:drug effects* / Q000503:physiopathology
chemical_list: D016627:Oxidopamine; D004298:Dopamine
keywords: Beta synchronization; DBS; ECoG; High-voltage spindles; Parkinson’s disease