title: [Expression and clinical significance of the genes of Wnt signaling pathway in keratocystic odontogenic tumor of the jaw bones].
abstract: OBJECTIVE
  To study the role of genes of Wnt signaling pathway in keratocystic odontogenic tumor (KCOT) of the jaw bones.
  
  
  METHODS
  Fresh specimens of KCOT and the same patient 's normal oral mucosa were obtained. Then RNA was extracted. Gene chip was used to detect the genes of Wnt signaling pathway.
  
  
  RESULTS
  Compared to normal oral mucosa, there were 5 genes of Wnt signaling pathway in KCOT changed, including CAMK2A down-regulated, FZD3, MAPK10, PRKX and WNT5a up-regulated.
  
  
  CONCLUSIONS
  There are abnormal expressions of genes of Wnt pathway in KCOT. Genes of Wnt pathway plays certain roles in KCOT.
authors: Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University. Qingdao 266003, Shandong Province, China.E-mail:lilykong9053@163.com.
authors: Li
authors: L
authors: Kong
authors: Bing-Chao
authors: BC
authors: Wang
authors: Rong-Tao
authors: RT
authors: Yuan
authors: Mu-Yun
authors: MY
authors: Jia
authors: Ke
authors: K
authors: Wang
mesh_terms: D006801:Humans; D009808:Odontogenic Tumors; D060449:Wnt Signaling Pathway