title: Post-void residual urinary volume is an independent predictor of biopsy results in men at risk for prostate cancer.
abstract: OBJECTIVE
  to determine whether peak flow rate (PFR) and post-void residual urinary volume (PVRUV) predict prostate biopsy outcome.
  
  
  METHODS
  The study population consisted of 1780 patients undergoing first prostate biopsy.
  
  
  RESULTS
  Patients with prostate cancer (PCa) had significantly greater prostate-specific antigen (PSA) and PFR but lower prostate volume (PVol) and PVRUV than those without PCa. Receiver operator characteristic curve analysis showed that PVol and PVRUV were the most accurate predictors of biopsy outcome. The addition of PVRUV to the multivariate logistic regression model based on standard clinical parameters (age, PSA, digital rectal examination, PVol) significantly increased the predictive accuracy of the model in both the population overall (79% vs. 77%; p=0.001) and patients with PSA levels up to 10 ng/ml (74.3% vs. 71.7%; p=0.005).
  
  
  CONCLUSIONS
  PVRUV seems to be an accurate non-invasive test to predict biopsy outcome that can be used alone or in combination with PVol in the decision-making process for men potentially facing a prostate biopsy.
authors: Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy luigicormio@libero.it.
authors: Luigi
authors: L
authors: Cormio
authors: Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy.
authors: Giuseppe
authors: G
authors: Lucarelli
authors: Department of Clinical Pathology, University of Foggia, Foggia, Italy.
authors: Giuseppe Stefano
authors: GS
authors: Netti
authors: Department of Nephrology Dialysis and Transplantation, and 4Pathology, University of Foggia, Foggia, Italy.
authors: Giovanni
authors: G
authors: Stallone
authors: Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy.
authors: Oscar
authors: O
authors: Selvaggio
authors: Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy.
authors: Francesco
authors: F
authors: Troiano
authors: Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy.
authors: Giuseppe
authors: G
authors: Di Fino
authors: Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy Department of Clinical Pathology, University of Foggia, Foggia, Italy Department of Nephrology Dialysis and Transplantation, and 4Pathology, University of Foggia, Foggia, Italy.
authors: Francesca
authors: F
authors: Sanguedolce
authors: Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy Department of Clinical Pathology, University of Foggia, Foggia, Italy Department of Nephrology Dialysis and Transplantation, and 4Pathology, University of Foggia, Foggia, Italy.
authors: Pantaleo
authors: P
authors: Bufo
authors: Department of Nephrology Dialysis and Transplantation, and 4Pathology, University of Foggia, Foggia, Italy.
authors: Giuseppe
authors: G
authors: Grandaliano
authors: Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy.
authors: Giuseppe
authors: G
authors: Carrieri
mesh_terms: D000368:Aged; D001706:Biopsy; D003657:Decision Making; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000652:urine; D012372:ROC Curve; D012307:Risk Factors; D014554:Urination
chemical_list: D017430:Prostate-Specific Antigen
keywords: Prostate-specific antigen; biopsy; prostate cancer; prostate volume; residual urinary volume