title: [(18)F-FDG PET/CT in the evaluation of patients suspected of paraneoplastic neurological syndrome].
abstract: OBJECTIVE
  This study aimed to determine the diagnostic impact of (18)F-FDG PET/CT based on the clinical features of paraneoplastic neurological syndrome (PNS).
  
  
  METHODS
  Multicenter retrospective and longitudinal study of patients with suspicion of PNS. The clinical picture was classified into classic (CS) and non-classic syndrome (NCS). After the follow-up, the definitive or possible diagnosis of PNS was established. The pictures that did not match any of the previous criteria were categorized as non-classifiable. The state of the onco-neural antibodies was studied. The PET/CT was classified as positive or negative for the detection of malignancy. The relationship between PET/CT findings and the final diagnosis was determined. The differences between variables (Pearson test X(2)) and the relationship between the results of the PET/CT and the final diagnosis were analyzed.
  
  
  RESULTS
  A total of 64 patients were analyzed, classifying 30% as CS and 42% as NCS. After the follow-up, 20% and 16% of subjects were diagnosed as possible and definitive PNS, respectively. Positive onco-neural antibodies were found in 13% of the patients. A definitive diagnosis of PNS was associated with a positive PET/CT (P=.08). A significant relation between antibodies expression and final diagnosis of neoplasia (P=.04) was demonstrated. The PET/CT correctly localized malignancy in 5/7 cases of invasive cancer.
  
  
  CONCLUSIONS
  The PET/CT showed a higher percentage of positive results in patients with definitive diagnosis of PNS. Despite the low prevalence of malignancy in our series, the PET/CT detected malignancy in a significant proportion of patients with invasive cancer.
authors: Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Ciudad Real, España. Electronic address: angarvice@yahoo.es.
authors: A M
authors: AM
authors: García Vicente
authors: Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
authors: C H
authors: CH
authors: Vega Caicedo
authors: Servicio de Oncología Médica, Hospital Virgen de la Luz, Cuenca, España.
authors: R
authors: R
authors: Mondéjar Solís
authors: Servicio de Medicina Interna, Complejo Hospitalario de Albacete, Albacete, España.
authors: J Á
authors: JÁ
authors: de Ayala Fernández
authors: Servicio de Neurología, Complejo Hospitalario de Toledo, Toledo, España.
authors: J A
authors: JA
authors: Garrido Robles
authors: Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
authors: F J
authors: FJ
authors: Pena Pardo
authors: Servicio de Neurología, Hospital de Puertollano, Ciudad Real, España.
authors: M
authors: M
authors: Muñoz Pasadas
authors: Servicio de Neurología, Hospital la Mancha Centro, Alcázar de San Juan, Ciudad Real, España.
authors: P
authors: P
authors: Del Saz Saucedo
authors: Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
authors: G A
authors: GA
authors: Jiménez Londoño
authors: Unidad de Investigación, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
authors: A
authors: A
authors: León Martín
authors: Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Ciudad Real, España.
authors: Á
authors: Á
authors: Soriano Castrejón
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000912:Antibodies, Neoplasm / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D020363:Limbic Encephalitis / Q000097:blood / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging; D009422:Nervous System Diseases / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging; D020361:Paraneoplastic Syndromes, Nervous System / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies
chemical_list: D000912:Antibodies, Neoplasm; D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F-FDG; Clasificación clínica; Clinical classification; PET/CT; PET/TC; Paraneoplastic neurological syndrome; Síndrome paraneoplásico neurológico