title: Cell type-specific separation of subicular principal neurons during network activities.
abstract: The hippocampal output structure, the subiculum, expresses two major memory relevant network rhythms, sharp wave ripple and gamma frequency oscillations. To this date, it remains unclear how the two distinct types of subicular principal cells, intrinsically bursting and regular spiking neurons, participate in these two network rhythms. Using concomitant local field potential and intracellular recordings in an in vitro mouse model that allows the investigation of both network rhythms, we found a cell type-specific segregation of principal neurons into participating intrinsically bursting and non-participating regular spiking cells. However, if regular spiking cells were kept at a more depolarized level, they did participate in a specific manner, suggesting a potential bimodal working model dependent on the level of excitation. Furthermore, intrinsically bursting and regular spiking cells exhibited divergent intrinsic membrane and synaptic properties in the active network. Thus, our results suggest a cell-type-specific segregation of principal cells into two separate groups during network activities, supporting the idea of two parallel streams of information processing within the subiculum.
authors: Cellular and Network Physiology Group, Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Joanna
authors: J
authors: Eller
authors: Cellular and Network Physiology Group, Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Shota
authors: S
authors: Zarnadze
authors: Cellular and Network Physiology Group, Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors: Peter
authors: P
authors: Bäuerle
authors: Cellular and Network Physiology Group, Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Cluster of excellence "NeuroCure", Berlin, Germany.
authors: Tamar
authors: T
authors: Dugladze
authors: Cellular and Network Physiology Group, Institute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany.
authors: Tengis
authors: T
authors: Gloveli
mesh_terms: D000200:Action Potentials; D000818:Animals; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D013569:Synapses / Q000502:physiology