title: Carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing.
abstract: The objective of this study was to develop a novel carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing. To prepare the crosslinked hydrogels, poly(vinyl alcohol) (PVA) was grafted with succinate acid to yield carboxyl-modified poly(vinyl alcohol) (PVA-COOH). Hydrogel films based on PVA-COOH and chitosan (CS) at different concentrations were crosslinked through the formation of amide linkages. The mechanical properties of these crosslinked hydrogel films in dry and swollen state were greatly improved with high swelling ratio. Water vapor and oxygen permeability evaluations indicated that crosslinked hydrogel films could maintain a moist environment over wound bed. Biocompatibility test showed the crosslinked hydrogels had no cytotoxicity and hemolytic potential. Gentamicin sulfate-loaded crosslinked hydrogel films showed sustained drug release profile, and could effectively suppress bacterial proliferation and protect wound from infection.
authors: School of Pharmaceutical Science, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, PR China.
authors: Di
authors: D
authors: Zhang
authors: School of Pharmaceutical Science, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, PR China.
authors: Wei
authors: W
authors: Zhou
authors: Engineering Research Center for Biomedical Materials, School of Life Science, Anhui University, 111 Jiulong Road, Hefei, Anhui 230601, PR China.
authors: Bing
authors: B
authors: Wei
authors: Engineering Research Center for Biomedical Materials, School of Life Science, Anhui University, 111 Jiulong Road, Hefei, Anhui 230601, PR China.
authors: Xin
authors: X
authors: Wang
authors: School of Pharmaceutical Science, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, PR China; Engineering Research Center for Biomedical Materials, School of Life Science, Anhui University, 111 Jiulong Road, Hefei, Anhui 230601, PR China. Electronic address: tangrp99@iccas.ac.cn.
authors: Rupei
authors: R
authors: Tang
authors: Engineering Research Center for Biomedical Materials, School of Life Science, Anhui University, 111 Jiulong Road, Hefei, Anhui 230601, PR China.
authors: Jiemin
authors: J
authors: Nie
authors: Engineering Research Center for Biomedical Materials, School of Life Science, Anhui University, 111 Jiulong Road, Hefei, Anhui 230601, PR China.
authors: Jun
authors: J
authors: Wang
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D047070:Bandages, Hydrocolloid / Q000009:adverse effects*; D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D020100:Hydrogels / Q000009:adverse effects / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011817:Rabbits; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D003432:Cross-Linking Reagents; D020100:Hydrogels; D011142:Polyvinyl Alcohol; D048271:Chitosan
keywords: Chitosan; Hydrogel; Poly(vinyl alcohol); Wound dressing