title: [Safety of polyethylene glycol conjugated L-asparaginase in patients with acute lymphoblastic leukemia and T cell non-Hodgkin lymphoma].
abstract: OBJECTIVE
  To evaluate the safety of polyethylene glycol conjugated L-asparaginase (PEG-Asp) for patients with adult acute lymphoblastic leukemia (ALL) and T cell non-Hodgkin lymphoma (T-NHL).
  
  
  METHODS
  A retrospective analysis was conducted on the clinical data of 101 young patients (≤40 years old) with ALL and T-NHL, diagnosed at Peking Union Medical College Hospital between January 2012 and June 2014.
  
  
  RESULTS
  A total of 480 doses of PEG-Asp were administered in 44 cases with ALL and 57 patients with T-NHL. Only one patient (0.2%) experienced mild allergic reaction. Other grade 3 or 4 toxicities of non-hematologic effects included low level of fibrogen (6.4%), elevated ALT (4.4%), blood glucose (2.3%), and triglyceridemia (2.3%), decreased albumin (0.8%) and elevated amylase (0.2%). Furthermore, 5 cases (1.0%) developed venous thrombosis, 9 cases (1.9%) hemorrage, 1 patient (0.2%) non-necrosis pancretitis.
  
  
  CONCLUSIONS
  The risk of allergic reaction incurred by PEG-Asp is very low. It can be used safely in ALL and T-NHL. Coagulation status should be monitored during the treatment.
authors: Department of Hematology, Chinese Academy of Medical Sciences Affiliated Peking Union Medical College Hospital, Beijing 100730, China.
authors: Xinxin
authors: X
authors: Cao
authors: Department of Hematology, Chinese Academy of Medical Sciences Affiliated Peking Union Medical College Hospital, Beijing 100730, China.
authors: Jian
authors: J
authors: Li
authors: Department of Hematology, Chinese Academy of Medical Sciences Affiliated Peking Union Medical College Hospital, Beijing 100730, China.
authors: Wei
authors: W
authors: Zhang
authors: Department of Hematology, Chinese Academy of Medical Sciences Affiliated Peking Union Medical College Hospital, Beijing 100730, China.
authors: Minghui
authors: M
authors: Duan
authors: Department of Hematology, Chinese Academy of Medical Sciences Affiliated Peking Union Medical College Hospital, Beijing 100730, China.
authors: Tienan
authors: T
authors: Zhu
authors: Department of Hematology, Chinese Academy of Medical Sciences Affiliated Peking Union Medical College Hospital, Beijing 100730, China.
authors: Bing
authors: B
authors: Han
authors: Department of Hematology, Chinese Academy of Medical Sciences Affiliated Peking Union Medical College Hospital, Beijing 100730, China.
authors: Junling
authors: J
authors: Zhuang
authors: Department of Hematology, Chinese Academy of Medical Sciences Affiliated Peking Union Medical College Hospital, Beijing 100730, China.
authors: Huacong
authors: H
authors: Cai
authors: Department of Hematology, Chinese Academy of Medical Sciences Affiliated Peking Union Medical College Hospital, Beijing 100730, China.
authors: Miao
authors: M
authors: Chen
authors: Department of Hematology, Chinese Academy of Medical Sciences Affiliated Peking Union Medical College Hospital, Beijing 100730, China.
authors: Daobin
authors: D
authors: Zhou
mesh_terms: D000328:Adult; D001215:Asparaginase; D006801:Humans; D016399:Lymphoma, T-Cell; D011092:Polyethylene Glycols; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D012189:Retrospective Studies; D020246:Venous Thrombosis
chemical_list: D011092:Polyethylene Glycols; C042705:pegaspargase; D001215:Asparaginase