title: Identification of the hot-spot areas for sickle cell disease using cord blood screening at a district hospital: an Indian perspective.
abstract: Sickle cell disease (SCD), a genetic disorder often reported late, can be identified early in life, and hot-spot areas may be identified to conduct genetic epidemiology studies. This study was undertaken to estimate prevalence and to identify hot spot area for SCD in Kalahandi district, by screening cord blood of neonates delivered at the district hospital as first-hand information. Kalahandi District Hospital selected for the study is predominated by tribal population with higher prevalence of SCD as compared to other parts of Odisha. Cord blood screening of SCD was carried out on 761 newborn samples of which 13 were screened to be homozygous for SCD. Information on area of parent's residence was also collected. Madanpur Rampur area was found to be with the highest prevalence of SCD (10.52 %) and the gene distribution did not follow Hardy-Weinberg Equation indicating un-natural selection. The approach of conducting neonatal screening in a district hospital for identification of SCD is feasible and appropriate for prioritizing area for the implementation of large-scale screening and planning control measures thereof.
authors: Regional Medical Research Centre (ICMR), Chandrasekharpur, Bhubaneswar, Odisha, India.
authors: Sujata
authors: S
authors: Dixit
authors: Kalahandi District Hospital, Bhawanipatna, Kalahandi, Odisha, India.
authors: Pushpansu
authors: P
authors: Sahu
authors: Regional Medical Research Centre (ICMR), Chandrasekharpur, Bhubaneswar, Odisha, India.
authors: Shantanu Kumar
authors: SK
authors: Kar
authors: Regional Medical Research Centre (ICMR), Chandrasekharpur, Bhubaneswar, Odisha, India. negisapna@yahoo.com.
authors: Sapna
authors: S
authors: Negi
keywords: Area specific; Cord blood screening; District hospital; Sickle cell