title: Is peritoneal dialysis still an equal option? Results of the Berlin pediatric nocturnal dialysis program.
abstract: BACKGROUND
  Peritoneal dialysis (PD) or conventional hemodialysis (HD) are considered to be equally efficient dialysis methods in children and adolescents. The aim of our study was to analyze whether an intensified, nocturnal HD program (NHD) is superior to PD in an adolescent cohort.
  
  
  METHODS
  Thirteen patients were prospectively enrolled in a NHD program. We measured uremia-associated parameters, parameters for nutrition, medication and blood pressure and analyzed the data. These data were compared to those of 13 PD controls, matched for gender, age and weight at the beginning the respective dialysis program and after 6 months of treatment.
  
  
  RESULTS
  Serum phosphate levels decreased significantly in the NHD group and remained unchanged in the PD group. Arterial blood pressure in the NHD was significantly lower despite the reduction of antihypertensive treatment, whereas blood pressure levels remained unchanged in the PD controls. Preexisting left ventricular hypertrophy resolved and albumin levels improved with NHD. Dietary restrictions could be lifted for those on NHD, whereas they remained in place for the patients on PD treatment. Residual diuresis remained unchanged after 6 months of either NHD or PD. NHD patients experienced fewer days of hospitalization than the PD controls.
  
  
  CONCLUSIONS
  Based on our results, NHD results in significantly improved parameters of uremia and nutrition. If individually and logistically possible, NHD should be the treatment modality of preference for older children and adolescents.
authors: Department of Pediatric Nephrology, Charité, Augustenburger Platz 1, 13353, Berlin, Germany, julia.thumfart@charite.de.
authors: Julia
authors: J
authors: Thumfart
authors: Tanja
authors: T
authors: Hilliger
authors: Christina
authors: C
authors: Stiny
authors: Steffen
authors: S
authors: Wagner
authors: Uwe
authors: U
authors: Querfeld
authors: Dominik
authors: D
authors: Müller
mesh_terms: D000293:Adolescent; D000419:Albuminuria / Q000150:complications; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D002648:Child; D002784:Cholesterol / Q000097:blood; D004032:Diet; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy / Q000628:therapy; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000534:rehabilitation / Q000628:therapy*; D008297:Male; D009752:Nutritional Status; D010530:Peritoneal Dialysis / Q000379:methods*; D010710:Phosphates / Q000097:blood; D014508:Urea / Q000378:metabolism
chemical_list: D000959:Antihypertensive Agents; D010710:Phosphates; D014508:Urea; D002784:Cholesterol