title: Sesquiterpenoids with Anti-MDR Staphylococcus aureus activities from Ferula ferulioides.
abstract: Seven new sesquiterpenoids together with 21 known sesquiterpenoid derivatives were isolated from the medicinal plant Ferula ferulioides (Steud.) Korovin. Their structures were elucidated by comprehensive spectroscopic analyses and chemical transformations. The isolated compounds were evaluated for their antibacterial activities against a panel of bacteria including multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA), displaying minimum inhibitory concentration (MIC) values in the range of 0.5-128 mg/l.
authors: School of Pharmacy, Fudan University, 826 Zhangheng Road, Zhangjiang Pudong, Shanghai 201203, P. R. China (phone: +86-21-51980109).
authors: Tao
authors: T
authors: Liu
authors: Shuangying
authors: S
authors: Wang
authors: Lili
authors: L
authors: Xu
authors: Wei
authors: W
authors: Fu
authors: Simon
authors: S
authors: Gibbons
authors: Qing
authors: Q
authors: Mu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D005309:Ferula / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D012717:Sesquiterpenes
keywords: Ferula ferulioides; Multidrug-resistant (MDR) bacteria; Sesquiterpenoids; Staphylococcus aureus