title: [Research on stability of melittin in different solvent systems].
abstract: The stability of melittin in different solvents (water, deoxygenated water, physiological saline, PBS, 50% ethanol, ethanol, glycerol)was studied and the results showed that the stability of melittin is not influenced by light, temperature and pH in 50% ethanol, which melittin can be completed dissolved when compared with ethanol and glycerol, in such, 50% ethanol was chosen as solvent storage when measured content of melittin. Then the effect of different concentrations of PBS, the pH of PBS and rat skin ho- mogenates were tested, and the results showed that melittin was degraded rapidly at low concentration solution and low ionic strength. Increasing pH of PBS and rat skin homogenate can accelerate the degradation of melittin. These researches provide an experimental ba- sis for further study of melittin.
authors: Ke-xin
authors: KX
authors: Shang
authors: Jie
authors: J
authors: Bai
authors: Hui-hao
authors: HH
authors: Wu
authors: Yang
authors: Y
authors: Lu
authors: Shou-ying
authors: SY
authors: Du
authors: Chang
authors: C
authors: Yang
authors: Yan-ke
authors: YK
authors: Cheng
mesh_terms: D000818:Animals; D004355:Drug Stability; D000431:Ethanol / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008555:Melitten / Q000737:chemistry*; D051381:Rats; D012867:Skin / Q000187:drug effects; D012997:Solvents / Q000737:chemistry*; D013696:Temperature
chemical_list: D012997:Solvents; D008555:Melitten; D000431:Ethanol