title: Craniofacial catch-up growth in intrauterine growth retarded rats following postnatal nutritional rehabilitation.
abstract: OBJECTIVE
  The aim of the study was to analyze the effect of postnatal nutritional rehabilitation on the craniofacial growth in rats with intrauterine growth retardation (IUGR).
  
  
  METHODS
  Wistar rats were assigned to one of the following groups: control, Sham-operated, and IUGR. The IUGR was produced by uterine vessels bending (day 14 of pregnancy). At days 1, 21, 42, 63, and 84 of postnatal life, each animal was X-rayed, and neural and facial length, width and height were measured. Volumetric and morphometric indices were calculated.
  
  
  RESULTS
  The decreased maternal-fetal blood flow during the last-third of the gestation period modified cranial size and shape of both sexes at birth.
  
  
  CONCLUSIONS
  Postnatal nutritional rehabilitation is not fully sufficient to reverse the prenatal growth retardation. There are specific responses depending on the sex and the age of the IUGR pups. Regardless of the changes in size, the shape is not modified during all the postnatal period.
authors: M E
authors: ME
authors: Luna
authors: F A
authors: FA
authors: Quintero
authors: M F
authors: MF
authors: Cesani
authors: M C
authors: MC
authors: Fucini
authors: V
authors: V
authors: Prío
authors: L M
authors: LM
authors: Guimarey
authors: E E
authors: EE
authors: Oyhenart
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D005147:Facial Bones / Q000254:growth & development*; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging / Q000534:rehabilitation*; D008297:Male; D018529:Nutritional Support / Q000379:methods*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D012886:Skull / Q000254:growth & development*