title: The use of low-volume polyethylene glycol containing ascorbic acid versus 2 L of polyethylene glycol plus bisacodyl as bowel preparation for colonoscopy.
abstract: OBJECTIVE
  Low-volume polyethylene glycol (PEG) bowel preparations have been developed to improve compliance for colonoscopy. Our study aimed to compare the efficacy and tolerability of low-volume PEG containing ascorbic acid for colonoscopy against 2 L of PEG plus bisacodyl.
  
  
  METHODS
  We prospectively enrolled consecutive inpatients who had not undergone polypectomy at the index colonoscopy and were subsequently referred for polypectomy at our hospital. A total of 62 patients were randomized to receive either low-volume PEG containing ascorbic acid (n = 31) or 2 L of PEG plus bisacodyl (n = 31) as a split-dose regimen in inpatients. The efficacy of preparation was determined using the Ottawa Bowel Preparation Score (OBPS) and a 4-point scale. Adverse events, tolerability, and willingness were evaluated using a questionnaire.
  
  
  RESULTS
  Based on the OBPS and 4-point scale, we determined that the efficacy of low-volume PEG containing ascorbic acid was comparable to that of the 2 L of PEG plus bisacodyl (p = 0.071 for OBPS, p = 0.056 for the 4-point scale). Adverse events were comparable between the two groups (p = 1.000). A greater proportion of patients in the low-volume PEG containing ascorbic acid (90.6%) and the 2L of PEG plus bisacodyl (96.9%) were willing to repeat the same preparation for subsequent colonoscopy.
  
  
  CONCLUSIONS
  Low-volume PEG containing ascorbic acid had comparable efficacy and tolerability to 2 L of PEG plus bisacodyl, when given as a split dose, for colonoscopy in inpatients. Split-dose low-volume PEG containing ascorbic acid is a good alternative for bowel preparation for colonoscopy in inpatients.
authors: Department of Internal Medicine, Ewha Medical Research Institute, Ewha Womans University School of Medicine , Seoul , Korea.
authors: Chung Hyun
authors: CH
authors: Tae
authors: Sung-Ae
authors: SA
authors: Jung
authors: Sun-Kyung
authors: SK
authors: Na
authors: Hye-Kyung
authors: HK
authors: Song
authors: Chang Mo
authors: CM
authors: Moon
authors: Seong-Eun
authors: SE
authors: Kim
authors: Ki-Nam
authors: KN
authors: Shim
authors: Hye-Kyung
authors: HK
authors: Jung
authors: Il Hwan
authors: IH
authors: Moon
mesh_terms: D000368:Aged; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001726:Bisacodyl / Q000627:therapeutic use*; D002400:Cathartics / Q000627:therapeutic use*; D003113:Colonoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011795:Surveys and Questionnaires
chemical_list: D002400:Cathartics; D001726:Bisacodyl; D011092:Polyethylene Glycols; D001205:Ascorbic Acid
keywords: ascorbic acid; bisacodyl; bowel preparation solutions; colonoscopy; polyethylene glycol