title: Organic-inorganic hybrid nanoparticles for bacterial inhibition: synthesis and characterization of doped and undoped ONPs with Ag/Au NPs.
abstract: Organic nanoparticles (ONPs) of lipoic acid and its doped derivatives ONPs/Ag and ONPs/Au were prepared and characterized by UV-Visible, EDS, and TEM analysis. The antibacterial properties of the ONPs ONPs/Ag and ONPs/Au were tested against bacterial strains (Staphylococcus aureus, Bacillus cereus, Escherichia coli and Salmonella typhi). Minimal Inhibitory Concentration (MIC) and bacterial growth inhibition tests show that ONPs/Ag are more effective in limiting bacterial growth than other NPs, particularly, for Gram positive than for Gram-negative ones. The order of bacterial cell growth inhibition was ONPs/Ag > ONPs > ONPs/Au. The morphology of the cell membrane for the treated bacteria was analyzed by SEM. The nature of bond formation of LA with Ag or Au was analyzed by molecular orbital and density of state (DOS) using DFT.
authors: Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Coyoacán, 04510 México D.F., Mexico. waitthinkandfast@hotmail.com.
authors: Carlos Alberto Huerta
authors: CA
authors: Aguilar
authors: Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Coyoacán, 04510 México D.F., Mexico. remin_1711@hotmail.com.
authors: Adriana Berenice Pérez
authors: AB
authors: Jiménez
authors: Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Coyoacán, 04510 México D.F., Mexico. antromsil@comunidad.unam.mx.
authors: Antonio Romero
authors: AR
authors: Silva
authors: Centre for Nanoscience & Nanotechnology, Panjab University, Chandigarh, Panjab 160014, India. navneetkau@pu.ac.in.
authors: Navneet
authors: N
authors: Kaur
authors: Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Coyoacán, 04510 México D.F., Mexico. pandiyan@unam.mx.
authors: Pandiyan
authors: P
authors: Thangarasu
authors: Facultad de Química, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Coyoacán, 04510 México D.F., Mexico.
authors: Jorge Manuel Vázquez
authors: JM
authors: Ramos
authors: Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, Panjab 140001, India. narindarchem@gmail.com.
authors: Narinder
authors: N
authors: Singh
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D006046:Gold; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012834:Silver; D008063:Thioctic Acid / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D012834:Silver; D008063:Thioctic Acid; D006046:Gold