title: Reexamination of the Direct Electrochemical Reduction ofS-Nitrosothiols.
abstract: We report here on the electrochemical reduction ofS-nitrosothiol species (RSNO). Nitric oxide (NO) is the reported common product from electrochemically reduced RSNOs at physiological pH. However, studies here at pH 7.4 show that during the reduction of RSNOs (-0.6 V to -0.9 V, vs. Ag/AgCl), no significant amount of NO is detected. Gas analysis suggests RSNO are reduced to nitrous oxide (N2O) at pH 7.4 and can only be converted back to NO at more oxidizing voltages. Interestingly, at pH 4.0, a direct one-electron reduction of RSNOs appears to occur and generates significant amounts of NO from RSNO species.
authors: Department of Chemistry, The University of Michigan, 930 North University Ave., Ann Arbor, MI 48109, USA.
authors: Bo
authors: B
authors: Peng
authors: Department of Chemistry, The University of Michigan, 930 North University Ave., Ann Arbor, MI 48109, USA.
authors: Mark E
authors: ME
authors: Meyerhoff
keywords: Electrochemical Reduction; Nitric Oxide; Nitrous Oxide; S-Nitrosothiols