title: Cu(I)/TF-BiphamPhos-catalyzed asymmetric Michael addition of cyclic ketimino esters to alkylidene malonates.
abstract: Cu(I)-catalyzed asymmetric Michael addition of cyclic ketimino esters with alkylidene malonates has been developed for efficient construction of β-branched α-amino acids containing adjacent quaternary and tertiary stereogenic centers in good yields with excellent diastereo-/enantioselectivities. The generated Michael adduct was further converted to the biologically important pyrrolizidine analogues via one-pot sequential reduction/lactamization.
authors: College of Chemistry and Chemical Engineering, Wuhan Textile University, Wuhan 430073, China.
authors: Zhi-Yong
authors: ZY
authors: Xue
authors: Zhi-Min
authors: ZM
authors: Song
authors: Chun-Jiang
authors: CJ
authors: Wang
mesh_terms: D002384:Catalysis; D055598:Chemical Phenomena; D056831:Coordination Complexes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D004952:Esters / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry; D013237:Stereoisomerism; D014965:X-Rays
chemical_list: D056831:Coordination Complexes; D004952:Esters; D007097:Imines; D008314:Malonates; D011758:Pyrroles; C549499:TF-BiphamPhos; D003300:Copper