title: Acute Exposure of the Mediobasal Hypothalamus to Amyloid-β25-35 Perturbs Hepatic Glucose Metabolism.
abstract: Patients with Alzheimer's disease (AD) have a higher risk for developing insulin resistance and diabetes. Amyloid plaques, a hallmark of AD, are composed of amyloid-β (Aβ). Because the mediobasal hypothalamus controls hepatic glucose production, we examined the hypothesis that its exposure to Aβ perturbs the regulation of glucose metabolism. The infusion of Aβ25-35, but not its scrambled counterpart, into the mediobasal hypothalamus of young rats, increased circulating glucose as a consequence of enhanced hepatic glucose production during pancreatic clamp studies. These findings suggest a link between AD and alterations of glucose metabolism.
authors: Department of Medicine and Diabetes Research Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.|Department of Basic Research, National Institute of Geriatrics, Ministry of Health, Mexico City, Mexico.
authors: Isabel
authors: I
authors: Arrieta-Cruz
authors: Department of Medicine and Diabetes Research Center, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
authors: Colette M
authors: CM
authors: Knight
authors: Roger
authors: R
authors: Gutiérrez-Juárez
mesh_terms: D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D015309:Glucose Clamp Technique; D007033:Hypothalamus, Middle / Q000187:drug effects*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016229:Amyloid beta-Peptides; D001786:Blood Glucose; D047908:Intracellular Signaling Peptides and Proteins; D010446:Peptide Fragments; D012333:RNA, Messenger; C074636:amyloid beta-protein (25-35); C582554:Pck1 protein, rat; D010729:Phosphoenolpyruvate Carboxykinase (GTP)
keywords: Alzheimer’s disease; amyloid-β; diabetes; glucose homeostasis; hyperglycemia; mediobasal hypothalamus