title: A clinician's perspective of the role of renal sympathetic nerves in hypertension.
abstract: The renal sympathetic nerves have significant contribution to the control of different aspects of kidney function. Early animal studies of renal denervation in a large number of different models of hypertension showed that that RDN improved BP control. Recently, data from prospective cohorts and randomized studies showed that renal denervation therapy (RDN) is a safe procedure but is associated with only modest reduction of ambulatory blood pressure (BP) in patients on intensive medical therapy. The main goal of this article is to review the results of preclinical and clinical studies on the contribution of the renal sympathetic nervous system to hypertension and the therapeutic applications of catheter-based renal denervation.
authors: American Society of Hypertension Comprehensive Hypertension Center, Department of Medicine, The University of Chicago Medicine Chicago, IL, USA.
authors: Alexandros
authors: A
authors: Briasoulis
authors: American Society of Hypertension Comprehensive Hypertension Center, Department of Medicine, The University of Chicago Medicine Chicago, IL, USA.
authors: George L
authors: GL
authors: Bakris
keywords: renal denervation therapy; resistant hypertension