title: Identification of novel thyroid cancer-related genes and chemicals using shortest path algorithm.
abstract: Thyroid cancer is a typical endocrine malignancy. In the past three decades, the continued growth of its incidence has made it urgent to design effective treatments to treat this disease. To this end, it is necessary to uncover the mechanism underlying this disease. Identification of thyroid cancer-related genes and chemicals is helpful to understand the mechanism of thyroid cancer. In this study, we generalized some previous methods to discover both disease genes and chemicals. The method was based on shortest path algorithm and applied to discover novel thyroid cancer-related genes and chemicals. The analysis of the final obtained genes and chemicals suggests that some of them are crucial to the formation and development of thyroid cancer. It is indicated that the proposed method is effective for the discovery of novel disease genes and chemicals.
authors: Department of Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Yang
authors: 0000-0002-1901-9778
authors: Y
authors: Jiang
authors: The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors: Peiwei
authors: P
authors: Zhang
authors: Department of Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Li-Peng
authors: LP
authors: Li
authors: Department of Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Yi-Chun
authors: YC
authors: He
authors: Department of Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Ru-jian
authors: RJ
authors: Gao
authors: Department of Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
authors: Yu-Fei
authors: YF
authors: Gao
mesh_terms: D000465:Algorithms; D030541:Databases, Genetic; D055808:Drug Discovery; D006801:Humans; D008024:Ligands; D060066:Protein Interaction Maps / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
chemical_list: D008024:Ligands