title: Vitamin B12, folate and iron levels in primary nocturnal enuresis.
abstract: OBJECTIVE
  Folate, vitamin B12 and iron are important vitamin and minerals which play role in the development of nervous system. The aim of this study was looking at the presence of folate, vitamin B12 and iron deficiency among patients with Primary nocturnal enuresis (PNE) and possible relation between the delay of central nervous system (CNS) development, PNE and folate, vitamin B12 and iron states.
  
  
  METHODS
  Consecutively applied forty patients with PNE (23 girls and 17 boys) and otherwise normal thirty control subjects (17 girls and 13 boys) were included in the study. Average ages (in range) of PNE and the control group were 9.2(6-12) years and 9.3 (6-12) years accordingly. Age, height, weight, complete blood count, blood vitamin B12, folate, ferritin and iron values of both groups were recorded and compared to each other.
  
  
  RESULTS
  Average vitamin B12 and folate levels of patients with PNE were significantly and statistically lower compared to those of the control group. Average blood iron of patients with PNE was significantly higher than that of the control group and also average ferritin level of the PNE group was detected to be higher than the control group but this relation was statistically insignificant.
  
  
  CONCLUSIONS
  Primary nocturnal enuresis is related to the delay in CNS maturation so it was thought that low vitamin B12 and folate which were found in patients with PNE may have role in the delay of CNS maturation. Additionally, further studies are needed to investigate the role of vitamin B12 and folate either alone or as combination in treatment of patients with PNE who have low vitamin B12and folate level.
authors: Sebahattin Albayrak, MD. Department of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
authors: Sebahattin
authors: S
authors: Albayrak
authors: Kürsad Zengin, MD. Department of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
authors: Kürsad
authors: K
authors: Zengin
authors: Serhat Tanik, MD. Department of Urology, Bozok University, School of Medicine, Yozgat, Turkey.
authors: Serhat
authors: S
authors: Tanik
authors: Ghaniya Daar, MD. Bozok University, School of Medicine, Yozgat, Turkey.Department of Pediatrics.
authors: Ghaniya
authors: G
authors: Daar
authors: Mustafa Yasar Ozdamar, MD. Bozok University, School of Medicine, Yozgat, Turkey.Department of Pediatric Surgery.
authors: Mustafa Yasar
authors: MY
authors: Ozdamar
authors: Hasan Bakirtas, MD. Bozok University, School of Medicine, Yozgat, Turkey.
authors: Hasan
authors: H
authors: Bakirtas
authors: M. Abdurrahim Imamoglu, MD. Bozok University, School of Medicine, Yozgat, Turkey.
authors: M Abdurrahim
authors: MA
authors: Imamoglu
authors: Mesut Gurdal, MD. Bozok University, School of Medicine, Yozgat, Turkey.
authors: Mesut
authors: M
authors: Gurdal
keywords: Folate; Iron; Primary Nocturnal Enuresis; Vitamin B12