title: Molecular mechanism and targets of the antimicrobial activity of metal nanoparticles.
abstract: The emergence of multi-resistant bacteria to drugs is recognized as a major cause of the increasing number of deaths in hospitals. Killing these bacteria require multiple expensive drugs that can have side effects. Metal nanoparticles may provide a new strategy to combat them. Due the antimicrobial and antiviral properties, nanoparticles (NPs) have outstanding biological properties that can be handled properly for desired applications. This review presents antibacterial and antiviral activity of metal NPs, including the molecular mechanisms by which NPs annihilate multidrug-resistant bacteria.
authors: Faik N
authors: FN
authors: Oktar
authors: Mehmet
authors: M
authors: Yetmez
authors: Denisa
authors: D
authors: Ficai
authors: Anton
authors: A
authors: Ficai
authors: Florica
authors: F
authors: Dumitru
authors: Politehnica University of Bucharest, Centre of Micro and Nanotechnology; 1-7 Polizu St., 011061, Bucharest, Romania. alexpica02@yahoo.com.
authors: Alexandra
authors: A
authors: Pica
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D016679:Genome, Viral / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry*; D019216:Metals, Heavy / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D019216:Metals, Heavy; D017382:Reactive Oxygen Species