title: Modulation of microRNAs by phytochemicals in cancer: underlying mechanisms and translational significance.
abstract: MicroRNAs (miRNAs) are small, endogenous noncoding RNAs that regulate a variety of biological processes such as differentiation, development, and survival. Recent studies suggest that miRNAs are dysregulated in cancer and play critical roles in cancer initiation, progression, and chemoresistance. Therefore, exploitation of miRNAs as targets for cancer prevention and therapy could be a promising approach. Extensive evidence suggests that many naturally occurring phytochemicals regulate the expression of numerous miRNAs involved in the pathobiology of cancer. Therefore, an understanding of the regulation of miRNAs by phytochemicals in cancer, their underlying molecular mechanisms, and functional consequences on tumor pathophysiology may be useful in formulating novel strategies to combat this devastating disease. These aspects are discussed in this review paper with an objective of highlighting the significance of these observations from the translational standpoint.
authors: Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA.
authors: Sanjeev K
authors: SK
authors: Srivastava
authors: Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA.
authors: Sumit
authors: S
authors: Arora
authors: Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA.
authors: Courey
authors: C
authors: Averett
authors: Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA.
authors: Seema
authors: 0000-0002-7188-3803
authors: S
authors: Singh
authors: Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA ; Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA.
authors: Ajay P
authors: AP
authors: Singh
mesh_terms: D001669:Biochemical Phenomena / Q000187:drug effects* / Q000235:genetics; D063646:Carcinogenesis / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D064209:Phytochemicals / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D035683:MicroRNAs; D064209:Phytochemicals