title: Fluorine-modified bisbenzimide derivative as a molecular probe for bimodal and simultaneous detection of DNAs by (19)F NMR and fluorescence.
abstract: 3,5-Bis(trifluoromethyl)benzene modified bisbenzimide H 33258 was synthesized as a (19)F magnetic resonance-based DNA detection probe. The chemical shift and fluorescence of the probe were significantly changed by the addition of hairpin DNAs having an AATT sequence. The probe enables (19)F NMR/fluorescence bimodal detection of the model DNA double strands simultaneously.
authors: School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahi-dai, Nomi, Ishikawa 923-1292, Japan. tsakamo@jaist.ac.jp.
authors: Takashi
authors: T
authors: Sakamoto
authors: Daisaku
authors: D
authors: Hasegawa
authors: Kenzo
authors: K
authors: Fujimoto
mesh_terms: D006690:Bisbenzimidazole / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D004247:DNA / Q000032:analysis*; D015342:DNA Probes / Q000138:chemical synthesis / Q000737:chemistry*; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D014050:Toluene / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D015342:DNA Probes; D014050:Toluene; D004247:DNA; D006690:Bisbenzimidazole