title: One-pot, three-component approach to the synthesis of 3,4,5-trisubstituted pyrazoles.
abstract: An operationally simple and high yielding protocol for the synthesis of polyfunctional pyrazoles has been developed through one-pot, three-component coupling of aldehydes, 1,3-dicarbonyls, and diazo compounds as well as tosyl hydrazones. The reaction proceeds through a tandem Knoevenagel condensation, 1,3-dipolar cycloaddition, and transition metal-free oxidative aromatization reaction sequence utilizing molecular oxygen as a green oxidant. The scope of the reaction was studied by varying the aldehyde, 1,3-dicarbonyl, and diazo component individually.
authors: †Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.|‡Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India.
authors: Ahmed
authors: A
authors: Kamal
authors: †Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.|‡Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India.
authors: K N Visweswara
authors: KN
authors: Sastry
authors: †Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
authors: D
authors: D
authors: Chandrasekhar
authors: †Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.|‡Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Hyderabad 500037, India.
authors: Geeta Sai
authors: GS
authors: Mani
authors: †Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
authors: Praveen Reddy
authors: PR
authors: Adiyala
authors: §Centre for X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
authors: Jagadeesh Babu
authors: JB
authors: Nanubolu
authors: ∥Centre for Nuclear Magnetic Resonance, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
authors: Kiran Kumar
authors: KK
authors: Singarapu
authors: †Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
authors: Ram Awatar
authors: RA
authors: Maurya
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001391:Azo Compounds / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D001391:Azo Compounds; D007659:Ketones; D011720:Pyrazoles