title: Hepatic lipid droplet biology: Getting to the root of fatty liver.
abstract: Hepatic steatosis is defined by the accumulation of lipid droplets (LDs). Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles that have important functions in hepatocytes beyond lipid storage. The lipid and protein composition of LDs is highly dynamic and influences their intrinsic metabolism and signaling properties, which ultimately links them to the changes in hepatic function. This concise review highlights recent discoveries in LD biology and unique aspects of hepatic LDs and their role in liver disease.
authors: Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN.
authors: Douglas G
authors: DG
authors: Mashek
authors: Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN.
authors: Salmaan A
authors: SA
authors: Khan
authors: Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN.
authors: Aishwarya
authors: A
authors: Sathyanarayan
authors: Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN.
authors: Jonathan M
authors: JM
authors: Ploeger
authors: Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN.
authors: Mallory P
authors: MP
authors: Franklin
mesh_terms: D018450:Disease Progression; D005234:Fatty Liver / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D066292:Lipid Droplets / Q000378:metabolism*; D050356:Lipid Metabolism / Q000502:physiology*; D008111:Liver Function Tests; D011379:Prognosis