title: Bioactive Maleic Anhydrides and Related Diacids from the Aquatic Hyphomycete Tricladium castaneicola.
abstract: Four maleic anhydride derivatives, tricladolides A-D (1-4), and three alkylidene succinic acid derivatives, tricladic acids A-C (5-7), were isolated from the aquatic hyphomycete Tricladium castaneicola. The structures of these compounds were determined by spectroscopic analysis, and all were found to be novel. The compounds exhibited inhibitory activity against fungi, particularly Phytophthora sp., a plant pathogen of oomycetes. The inhibitory activity of these metabolites revealed the importance of the cyclic anhydride structure and the lipophilicity of the alkyl side chain. On the other hand, the cytotoxicity of the compounds against B16 melanoma cells indicated that the cyclic anhydride structure was not essential.
authors: †Research Center for Materials Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.
authors: Chunguang
authors: C
authors: Han
authors: ‡Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.
authors: Hiroyuki
authors: H
authors: Furukawa
authors: ‡Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.
authors: Tomohiko
authors: T
authors: Tomura
authors: Ryosuke
authors: R
authors: Fudou
authors: ⊥Institute for Innovation, Ajinomoto Co., Inc., Kawasaki, Kanagawa 210-8681, Japan.
authors: Kenichi
authors: K
authors: Kaida
authors: ∥Center for Nutraceutical and Pharmaceutical Materials, Myongji University, Cheoin-gu, Yongin, Gyeonggi-Do 449-728, Korea.
authors: Bong-Keun
authors: BK
authors: Choi
authors: #Research Institute for Biological Functions, Chubu University, Kasugai 487-8501, Japan.
authors: Genji
authors: G
authors: Imokawa
authors: ‡Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan.
authors: Makoto
authors: M
authors: Ojika
mesh_terms: D004354:Drug Screening Assays, Antitumor; D007564:Japan; D008299:Maleic Anhydrides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008546:Melanoma, Experimental / Q000188:drug therapy; D003904:Mitosporic Fungi / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010838:Phytophthora / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013386:Succinates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D008299:Maleic Anhydrides; D013386:Succinates; C000600753:tricladic acid A; C000600755:tricladic acid B; C000600756:tricladic acid C