title: Fixed drug eruptions with modafinil.
abstract: Modafinil is a psychostimulant drug, which has been approved by the US Food and Drug Administration for the treatment of narcolepsy associated excessive daytime sleepiness, sleep disorder related to shift work, and obstructive sleep apnea syndrome. However, presently it is being used as a lifestyle medicine; in India, it has been misused as an "over the counter" drug. Modafinil is known to have several cutaneous side effects. Fixed drug eruption (FDE) is a distinctive drug induced reaction pattern characterized by recurrence of eruption at the same site of the skin or mucous membrane with repeated systemic administration. Only two case reports exist in the literature describing modafinil induced FDE until date. Here, we report two similar cases. The increasing use of this class of drug amongst the medical personnel might be posing a threat to the proper use and encouraging subsequent abuse. There might be a considerable population using these drugs unaware of the possible adverse effects. Authorities should be more alert regarding the sale and distribution of such medicines.
authors: Department of Dermatology, Venereology and Leprosy, NRS Medical College, Kolkata, West Bengal, India.
authors: Loknath
authors: L
authors: Ghoshal
authors: Department of Psychiatry, R. G. Kar Medical College, Kolkata, West Bengal, India.
authors: Mausumi
authors: M
authors: Sinha
mesh_terms: D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D000077408:Modafinil; D000068656:Mometasone Furoate / Q000008:administration & dosage / Q000627:therapeutic use; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use; D064690:Wakefulness-Promoting Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D055815:Young Adult
chemical_list: D001559:Benzhydryl Compounds; D064690:Wakefulness-Promoting Agents; D000068656:Mometasone Furoate; D014222:Triamcinolone Acetonide; D000077408:Modafinil
keywords: Fixed drug eruption; modafinil; psychostimulant