title: Transcriptome sequencing reveals CHD1 as a novel fusion partner of RUNX1 in acute myeloid leukemia with t(5;21)(q21;q22).
abstract: BACKGROUND
  RUNX1/AML1, which is a Runt family transcription factor critical for normal hematopoiesis, is frequently mutated or translocated in a broad spectrum of hematopoietic malignancies.
  
  
  RESULTS
  We describe here the case of a 54-year-old female developed acute myeloid leukemia with a t(5;21)(q21;q22). Transcriptome sequencing identified the chromodomain-helicase-DNA-binding protein 1 gene, CHD1, as a novel partner gene of RUNX1. Furthermore, the patient was found to harbor FLT3-ITD mutation, which might collaborated with CHD1-RUNX1 in the development of acute myeloid leukemia.
  
  
  CONCLUSIONS
  We have identified CHD1 as the RUNX1 fusion partner in acute myeloid leukemia with t(5;21)(q21;q22).
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. shucheng.yh@163.com.
authors: Hong
authors: H
authors: Yao
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. jinlanpan@aliyun.com.
authors: Jinlan
authors: J
authors: Pan
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. 414081340@qq.com.
authors: Chunxiao
authors: C
authors: Wu
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. shj98538@sina.com.
authors: Hongjie
authors: H
authors: Shen
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. carolxjd@163.com.
authors: Jundan
authors: J
authors: Xie
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. wangqr001@126.com.
authors: Qinrong
authors: Q
authors: Wang
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. sudawlj@163.com.
authors: Lijun
authors: L
authors: Wen
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. shirley-1214@163.com.
authors: Qian
authors: Q
authors: Wang
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. marodsz@163.com.
authors: Liang
authors: L
authors: Ma
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. Lizzysuda@126.com.
authors: Lili
authors: L
authors: Wu
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. ping.chengcheng@163.com.
authors: Nana
authors: N
authors: Ping
authors: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou, P.R. China. zhaoy@suda.edu.cn.
authors: Yun
authors: Y
authors: Zhao
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. ainingsun@hotmail.com.
authors: Aining
authors: A
authors: Sun
authors: Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, P.R. China. chensuning@sina.com.|Collaborative Innovation Center of Hematology, Soochow University, Suzhou, P.R. China. chensuning@sina.com.
authors: Suning
authors: S
authors: Chen
mesh_terms: D056905:Chromosome Breakpoints; D002891:Chromosomes, Human, Pair 21; D002895:Chromosomes, Human, Pair 5; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D004265:DNA Helicases / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D023061:Gene Order; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics*; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D017422:Sequence Analysis, DNA; D059467:Transcriptome; D014178:Translocation, Genetic
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D015514:Oncogene Proteins, Fusion; D004265:DNA Helicases; C080359:CHD1 protein, human