title: Close encounters of the lysosome-peroxisome kind.
abstract: Lysosomes provide a major source for cellular cholesterol; however, most of this cholesterol is trafficked to the plasma membrane via unknown mechanisms. Chu et al. identify an unexpected role for peroxisomes in the transport of cholesterol from the lysosome to the plasma membrane via a lysosome-peroxisome membrane contact site.
authors: Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
authors: Yui
authors: Y
authors: Jin
authors: Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
authors: Bethany S
authors: BS
authors: Strunk
authors: Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA. Electronic address: lweisman@umich.edu.
authors: Lois S
authors: LS
authors: Weisman
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D020675:Peroxisomes / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000378:metabolism*
chemical_list: D034741:RNA, Small Interfering; D002784:Cholesterol