title: Deep brain stimulation in the globus pallidus compensates response inhibition deficits: evidence from pantothenate kinase-associated neurodegeneration.
abstract: Fronto-striatal loops are important for many cognitive control processes, like response inhibition, and it has been suggested that the globus pallidus is of particular importance for these processes. In the current study, we investigate the effect of deep brain stimulation in the GP on response inhibition processes by means of neurophysiological (EEG) methods. We perform a case-control study in neuroaxonal dystrophy pantothenate kinase-associated neurodegeneration (PKAN) using single-case statistics. We control the signal-to-noise ratio of the EEG data. The data show that disease-related changes in the globus pallidus lead to dysfunctions in response inhibition processes. Dysfunctions in the GP seem to affect controlled, but not automatized behavior as evidenced by an increased rate of false alarms and attenuation of inhibition-related neurophysiological correlates. With respect to controlled behavior in terms of response inhibition, it seems that pre-motor subprocesses and not evaluation subprocesses are affected. Deep brain stimulation in the globus pallidus seems to be able to compensate the effects of disease-related changes in this structure and normalizes response inhibition performance and their electrophysiological correlates in PKAN.
authors: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany.
authors: Moritz
authors: M
authors: Mückschel
authors: Abteilung Neuropädiatrie, Faculty of Medicine of the TU Dresden, Dresden, Germany.
authors: Martin
authors: M
authors: Smitka
authors: Department of Neurology, Faculty of Medicine of the TU Dresden, Dresden, Germany.
authors: Andreas
authors: A
authors: Hermann
authors: Abteilung Neuropädiatrie, Faculty of Medicine of the TU Dresden, Dresden, Germany.
authors: Maja
authors: M
authors: von der Hagen
authors: Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Schubertstrasse 42, 01309, Dresden, Germany. christian.beste@uniklinikum-dresden.de.
authors: Christian
authors: C
authors: Beste
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology*; D046690:Deep Brain Stimulation; D004569:Electroencephalography; D056344:Executive Function / Q000502:physiology*; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D006211:Pantothenate Kinase-Associated Neurodegeneration / Q000523:psychology* / Q000628:therapy*; D016896:Treatment Outcome
keywords: Basal ganglia; Cognitive control; Deep brain stimulation; EEG; Iron; PKAN