title: Safety and Efficacy Study of the Cyclooxygenase-2 Inhibitor Parecoxib Sodium Applied for Postoperative Analgesia After Endo-Nasal Operation.
abstract: OBJECTIVE
  To evaluate the safety and efficacy of the cyclooxygenase-2 inhibitor parecoxib sodium after endo-nasal operation.
  
  
  METHODS
  Patients aged 18 to 55 years with body mass index (BMI) ≤25 and ASAI~II who were undergoing endo-nasal operation were randomly allocated to receive either i.v. parecoxib sodium 40 mg or i.v. placebo (saline) 2 mL 15 minutes before induction of anesthesia. The magnitude of pain was measured using the visual analogue scale (VAS) and recorded on awakening, then at interval of 1, 2, 4, 6, 8, 12, and 24 hours after operation. Safety evaluation including nausea, vomiting, dry mouth, drowsiness, urinary retention, respiratory depression, surgical site bleeding, and so on was assessed. The patients' satisfaction of the postoperative analgesia was recorded and compared between the 2 groups.
  
  
  RESULTS
  A total of 64 patients were enrolled in the study, including 31 in parecoxib group and 33 in placebo group. The VAS scores at 1, 2, 4, 6, 8 hours after operation were significantly lower in parecoxib group than in placebo group (P < 0.05). The P values were 0.002, <0.001, 0.001 at 2, 4, 6 hours after operation, respectively. The percentage of the patients who considered the postoperative analgesia "good" or "excellent" was 45.2% in parecoxib group and 9.1% in placebo group. There were no serious side effects in both groups.
  
  
  CONCLUSIONS
  Parecoxib sodium was effective and safe when used for postoperative analgesia in endo-nasal operation.
authors: Department of Anesthesiology, Tongji Hospital, Tongji Medical College of Hust, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
authors: Hong
authors: H
authors: Chen
authors: Department of Anesthesiology, Tongji Hospital, Tongji Medical College of Hust, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
authors: Ailin
authors: A
authors: Luo
mesh_terms: D000293:Adolescent; D000328:Adult; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D004724:Endoscopy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013517:Otorhinolaryngologic Surgical Procedures / Q000009:adverse effects / Q000379:methods*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D017060:Patient Satisfaction; D055815:Young Adult
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D007555:Isoxazoles; C409945:parecoxib
keywords: analgesia; cyclooxygenase-2 inhibitor; endo-nasal operation; parecoxib