title: The potential of LINGO-1 as a therapeutic target for essential tremor.
abstract: BACKGROUND
  LINGO-1 is a negative regulator of neuronal survival, oligodendrocyte differentiation and axonal outgrowth and regeneration, because it interacts with diverse growth factor receptors blocking or inhibiting their action. Consistent findings obtained in vitro and in animal models suggest that anti-LINGO-1 therapy may be useful in neurodegenerative disorders such as multiple sclerosis (MS), Parkinson's disease or essential tremor (ET). Moreover, genetic and pathological evidence provide a robust link between LINGO-1 and ET.
  
  
  METHODS
  In this review, we present an overview of current knowledge on findings linking LINGO-1 and ET, with a special focus on genetic linkage, we include an overview of LINGO1 gene variations according to the 1000 genomes catalog, and we identify potential gene areas where common changes occur because, as well as the risk developing ET, LINGO1 genetic changes may influence the response to anti-LINGO-1 therapy.
  
  
  CONCLUSIONS
  The goal of anti-LINGO-1 therapy in neurodegenerative diseases is to ease the brakes of neuronal growth and recovery. An anti-LINGO-1 antibody is under clinical trials for MS patients. Before planning trials with ET patients, refinement on the genetic link between LINGO1 and ET, and a detailed genetic and phenotypic assessment of ET patients to be enrolled, should be carried out.
authors: University of Extremadura, Department of Pharmacology , Avda. de la Universidad s/n, E-10071, Cáceres , Spain +34927257000 Ext 86897 ; +34924289676 ; jagundez@unex.es.
authors: José Ag
authors: JA
authors: Agúndez
authors: Félix Javier
authors: FJ
authors: Jiménez-Jimenez
authors: Hortensia
authors: H
authors: Alonso-Navarro
authors: Elena
authors: E
authors: García-Martín
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D020329:Essential Tremor / Q000503:physiopathology / Q000628:therapy*; D014644:Genetic Variation; D006801:Humans; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D009103:Multiple Sclerosis / Q000503:physiopathology / Q000628:therapy; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000503:physiopathology / Q000628:therapy*
chemical_list: D000906:Antibodies; C482293:LINGO1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins
keywords: BIIB033; LINGO-1; Li81; clinical trials; essential tremor; genetic linkage