title: Utility of microRNAs and siRNAs in cervical carcinogenesis.
abstract: MicroRNAs and siRNAs belong to a family of small noncoding RNAs which bind through partial sequence complementarity to 3'-UTR regions of mRNA from target genes, resulting in the regulation of gene expression. MicroRNAs have become an attractive target for genetic and pharmacological modulation due to the critical function of their target proteins in several signaling pathways, and their expression profiles have been found to be altered in various cancers. A promising technology platform for selective silencing of cell and/or viral gene expression using siRNAs is currently in development. Cervical cancer is the most common cancer in women in the developing world and sexually transmitted infection with HPV is the cause of this malignancy. Therefore, a cascade of abnormal events is induced during cervical carcinogenesis, including the induction of genomic instability, reprogramming of cellular metabolic pathways, deregulation of cell proliferation, inhibition of apoptotic mechanisms, disruption of cell cycle control mechanisms, and alteration of gene expression. Thus, in the present review article, we highlight new research on microRNA expression profiles which may be utilized as biomarkers for cervical cancer. Furthermore, we discuss selective silencing of HPV E6 and E7 with siRNAs which represents a potential gene therapy strategy against cervical cancer.
authors: Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad No. 655, Cerrada los Pinos y Caminera, Colonia Santa María Ahuacatitlán, 62100 Cuernavaca, MOR, Mexico.
authors: Sacnite del Mar
authors: Sdel M
authors: Díaz-González
authors: Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad No. 655, Cerrada los Pinos y Caminera, Colonia Santa María Ahuacatitlán, 62100 Cuernavaca, MOR, Mexico.
authors: Jessica
authors: 0000-0001-7090-1259
authors: J
authors: Deas
authors: Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad No. 655, Cerrada los Pinos y Caminera, Colonia Santa María Ahuacatitlán, 62100 Cuernavaca, MOR, Mexico.
authors: Odelia
authors: O
authors: Benítez-Boijseauneau
authors: Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad No. 655, Cerrada los Pinos y Caminera, Colonia Santa María Ahuacatitlán, 62100 Cuernavaca, MOR, Mexico.
authors: Claudia
authors: C
authors: Gómez-Cerón
authors: Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad No. 655, Cerrada los Pinos y Caminera, Colonia Santa María Ahuacatitlán, 62100 Cuernavaca, MOR, Mexico.
authors: Victor Hugo
authors: VH
authors: Bermúdez-Morales
authors: National Institute of Genomic Medicine, Periférico Sur No. 4809, Colonia Arenal Tepepan, Delegación Tlalpan, 14610 Mexico City, DF, Mexico.
authors: Mauricio
authors: M
authors: Rodríguez-Dorantes
authors: Oncogenomics Laboratory, National Cancer Institute of Mexico, Tlalpan, Avenida San Fernando No. 22, Colonia Sección XVI, Delegación Tlalpan, 14080 Mexico City, DF, Mexico ; Biomedicine Unit, FES-Iztacala UNAM, Avenida De los Barrios s/n. Colonia Los Reyes Iztacala, 54090 Tlalnepantla de Baz, MEX, Mexico.
authors: Carlos
authors: C
authors: Pérez-Plasencia
authors: Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad No. 655, Cerrada los Pinos y Caminera, Colonia Santa María Ahuacatitlán, 62100 Cuernavaca, MOR, Mexico.
authors: Oscar
authors: O
authors: Peralta-Zaragoza
mesh_terms: D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism; D027383:Papillomaviridae / Q000235:genetics / Q000378:metabolism; D030361:Papillomavirus Infections / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D009856:Oncogene Proteins, Viral; D012334:RNA, Neoplasm; D034741:RNA, Small Interfering