title: H₈-BINOL chiral imidodiphosphoric acid catalyzed highly enantioselective aza-Friedel-Crafts reactions of pyrroles and enamides/imines.
abstract: The first enantioselective aza-Friedel-Crafts reaction between pyrroles and enamides has been achieved by using a novel H8-BINOL-type imidodiphosphoric acid catalyst. This methodology was also applied to the highly enantioselective aza-Friedel-Crafts reaction between pyrroles and imines. The catalyst loadings in these two reactions are low (0.3-2 mol%). Both processes are amenable to gram scales.
authors: College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China. jiangyijun@jlu.edu.cn suoqin@jlu.edu.cn.
authors: Kun
authors: K
authors: Wu
authors: Ming-Hua
authors: MH
authors: Zhuo
authors: Di
authors: D
authors: Sha
authors: Yan-Sen
authors: YS
authors: Fan
authors: Dong
authors: D
authors: An
authors: Yi-Jun
authors: YJ
authors: Jiang
authors: Suoqin
authors: S
authors: Zhang
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004164:Diphosphonates / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D000588:Amines; C406944:BINOL, naphthol; D004164:Diphosphonates; D007097:Imines; D009284:Naphthols; D011758:Pyrroles; C016514:imidodiphosphonic acid