title: [The diagnostic of defects of inborn immunity under B-cell tumors of lymphatic system].
abstract: The genetic characteristics are key risk factors of development of many human neoplasms including B-cell tumors of lymphatic system. The relationship between polymorphic variants of genes FCGR2A (His 1 66Agr), CD14 (C-159T). IL1β (T-31C), IL2 (7:330G) and 7LR2 (Arg753Ghn) and development of various forms of B-cell tumors of lymphatic system in 80 patients was investigated. The statistically significant differences of rates of particiular genotypes of single nucleotid polymorphisms of genes FCGR2A, CD14. IL1β, IL2 and TLR2 in patients with indolent and aggressive types of course of non-Hodgkin lymphoma and also multiple myeloma. The results prove hypothesis that genetic variants of genes of inborn immune response effect the origin and character of course of different types of lymphoproliferative diseases. The markers can become additional prognostic characteristics of benign and aggressive course of tumors.
authors: E L
authors: EL
authors: Nazarova
authors: V I
authors: VI
authors: Shardakov
authors: V T
authors: VT
authors: Dem'ianova
authors: T P
authors: TP
authors: Zagoskina
authors: E N
authors: EN
authors: Zotina
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D018950:Lipopolysaccharide Receptors / Q000235:genetics; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D017452:Receptors, IgG / Q000235:genetics; D051195:Toll-Like Receptor 2 / Q000235:genetics
chemical_list: C445323:FCGR2A protein, human; C508585:IL1B protein, human; C508594:IL2 protein, human; D053583:Interleukin-1beta; D007376:Interleukin-2; D018950:Lipopolysaccharide Receptors; D017452:Receptors, IgG; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2