title: Coenzyme Q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxidation in chronic gastritis associated with H. pylori infection.
abstract: Chronic gastritis associated with H. pylori infection causes oxidative stress in the stomach. This study aimed to evaluate the therapeutic effects of coenzyme q10 among gastric patients infected by H. pylori. By a clinical trial, chronic gastric patients infected by H. pylori were randomly divided into 2 groups: intervention and placebo. The placebo group received a standard triple therapy regimen, and the intervention group received the triple regimen + coenzyme Q10 (CoQ10). Mean inflammation score; serum levels of 3 serum markers were then compared. A total of 100 participants of whom 67% were female were evaluated. The mean age of participants was 59.4 ± 11.4 years. The mean inflammation score was considerably decreased at the end of the study, in the intervention group. The mean levels of total antioxidant capacity (TAC) and glutathione peroxidase (GPx) at the end of the study were reduced among the triple therapy group (P < .05, P =.03 respectively). The mean levels of TAC and GPx were significantly higher among the intervention group at the end of the study compared with those at the start of the study. The combination of triple therapy with CoQ10 demonstrated an effective outcome on the mucosal inflammation, and stress oxidative in patients with chronic gastritis.
authors: Student Research Committee, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors: Asghar
authors: A
authors: Rahmani
authors: Dept. of Gastroenterology, Faculty of Medicine, lIlam University of Medical Sciences, Ilam, Iran.
authors: Ghobad
authors: G
authors: Abangah
authors: Social Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors: Atefeh
authors: A
authors: Moradkhani
authors: Dept. of Pathology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors: Mohammad Reza
authors: MR
authors: Hafezi Ahmadi
authors: Dept. of Social Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
authors: Khairollah
authors: K
authors: Asadollahi
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005756:Gastritis / Q000097:blood / Q000188:drug therapy*; D005979:Glutathione Peroxidase / Q000097:blood; D016481:Helicobacter Infections / Q000097:blood / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008795:Metronidazole / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D009942:Organometallic Compounds / Q000494:pharmacology / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects; D013752:Tetracycline / Q000494:pharmacology / Q000627:therapeutic use; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D009942:Organometallic Compounds; D014451:Ubiquinone; D008795:Metronidazole; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; C024989:coenzyme Q10; D013752:Tetracycline; C002791:bismuth tripotassium dicitrate
keywords: H. pylori; chronic gastritis; coenzyme Q10 (CoQ10); glutathione peroxidase (GPx); inflammation; malondialdehyde (MDA); total antioxidant capacity (TAC)