title: Blood typing using microstructured waveguide smart cuvette.
abstract: We introduce a sensitive method that allows one to distinguish positive and negative agglutination reactions used for blood typing and determination of Rh affinity with a high precision. The method is based on the unique properties of photonic crystal waveguides, i.e., microstructured waveguides (MSWs). The transmission spectrum of an MSW smart cuvette filled by a specific or nonspecific agglutinating serum depends on the scattering, refractive, and absorptive properties of the blood probe. This concept was proven in the course of a laboratory clinical study. The obtained ratio of the spectral-based discrimination parameter for positive and negative reactions (I+/I-) was found to be 16 for standard analysis and around 2 for used sera with a weak activity.
authors: SPE Nanostructured Glass Technology, 101, 50 Let Oktyabrya Avenue, Saratov 410033, RussiabSaratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskaya Street, Saratov 410012, Russia.
authors: Anastasiya A
authors: AA
authors: Zanishevskaya
authors: SPE Nanostructured Glass Technology, 101, 50 Let Oktyabrya Avenue, Saratov 410033, RussiacSaratov State University, Department of Semiconductor Physics, 83 Astrakhanskaya Street, Saratov 410012, Russia.
authors: Andrey A
authors: AA
authors: Shuvalov
authors: SPE Nanostructured Glass Technology, 101, 50 Let Oktyabrya Avenue, Saratov 410033, RussiabSaratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskaya Street, Saratov 410012, Russia.
authors: Yulia S
authors: YS
authors: Skibina
authors: Saratov State University, Research-Educational Institute of Optics and Biophotonics, 83 Astrakhanskaya Street, Saratov 410012, RussiadInstitute of Precise Mechanics and Control RAS, Laboratory of Laser Diagnostics of Technical and Living Systems, 24 Raboc.
authors: Valery V
authors: VV
authors: Tuchin
mesh_terms: D001788:Blood Grouping and Crossmatching / Q000295:instrumentation*; D001800:Blood Specimen Collection / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008904:Miniaturization; D012031:Refractometry / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000295:instrumentation*; D020349:Surface Plasmon Resonance / Q000295:instrumentation*