title: Urinary tract infections: epidemiology, mechanisms of infection and treatment options.
abstract: Urinary tract infections (UTIs) are a severe public health problem and are caused by a range of pathogens, but most commonly by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterococcus faecalis and Staphylococcus saprophyticus. High recurrence rates and increasing antimicrobial resistance among uropathogens threaten to greatly increase the economic burden of these infections. In this Review, we discuss how basic science studies are elucidating the molecular details of the crosstalk that occurs at the host-pathogen interface, as well as the consequences of these interactions for the pathophysiology of UTIs. We also describe current efforts to translate this knowledge into new clinical treatments for UTIs.
authors: 1] Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110-1093, USA. [2].
authors: Ana L
authors: AL
authors: Flores-Mireles
authors: 1] Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110-1093, USA. [2].
authors: Jennifer N
authors: JN
authors: Walker
authors: Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110-1093, USA.
authors: Michael
authors: M
authors: Caparon
authors: Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, Box 8230, 660 South Euclid Avenue, St. Louis, Missouri 63110-1093, USA.
authors: Scott J
authors: SJ
authors: Hultgren
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000191:economics / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000191:economics / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents