title: Gene-Gene Interplay and Gene-Diet Interactions Involving the MTNR1B rs10830963 Variant with Body Weight Loss.
abstract: OBJECTIVE
  Investigation of the genetic makeup may facilitate the implementation of more personalized nutritional interventions. The aims were to examine whether the rs10830963 MTNR1B polymorphism affects weight loss in response to a hypocaloric diet and to find potential gene-gene interplays and gene-diet interactions.
  
  
  METHODS
  167 subjects enrolled in a personalized nutritional intervention for weight loss (3-6 weeks) were examined for anthropometric measurements, dietary habits and physical activity at baseline and at the first follow-up visit. Three polymorphisms, which have previously been associated with body weight regulation, rs10830963 (MTNR1B), rs9939609 (FTO) and rs17782313 (MC4R), were analyzed using the Luminex® 100/200™ System.
  
  
  RESULTS
  After adjusting for covariates, females with the rs10830963 CG/GG genotype showed lower weight loss than those with the CC genotype. In the total population, carriers of variant alleles of both FTO and MC4R showed a significant association with MTNR1B and weight loss outcome. Moreover, among women, higher total protein and animal protein intakes were associated with a lower weight loss in G allele carriers of the MTNR1B variant.
  
  
  CONCLUSIONS
  Our data evidenced that rs10830963 MTNR1B polymorphism could be associated with individual differences in weight loss induced by a hypocaloric diet. This association was influenced by FTO and MC4R loci and modified by baseline protein intake.
authors: Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain.
authors: Leticia
authors: L
authors: Goni
authors: Marta
authors: M
authors: Cuervo
authors: Fermin I
authors: FI
authors: Milagro
authors: J Alfredo
authors: JA
authors: Martínez
mesh_terms: D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D004038:Diet, Reducing; D004843:Epistasis, Genetic; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D054647:Nutrigenomics; D009765:Obesity / Q000178:diet therapy / Q000235:genetics / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D057285:Precision Medicine; D011506:Proteins / Q000235:genetics; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics; D044123:Receptor, Melatonin, MT2 / Q000235:genetics*; D015431:Weight Loss / Q000235:genetics*
chemical_list: C470072:MC4R protein, human; C573871:MTNR1B protein, human; D011506:Proteins; D044105:Receptor, Melanocortin, Type 4; D044123:Receptor, Melatonin, MT2; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human