title: Genetic variations in microRNA genes and susceptibility to hepatocellular carcinoma.
abstract: We conducted a hospital-based case-control study to investigate the effect of the miR-146aG>C and miR-499A>G polymorphisms on the risk of hepatocellular carcinoma (HCC) in a Chinese population. This study was 1:1 matched case-control study consisting of 184 HCC patients and 184 control subjects. miR-146aG>C and miR-499A>G polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism. Multivariate regression analyses showed that subjects carrying the miR-146a G allele and miR-499 G allele were associated with a non-significant increased risk of HCC compared with subjects with the homozygous allele, with adjusted odds ratios (95% confidence interval) of 1.38 (0.97-1.84) and 1.40 (0.99-2.08), respectively. Moreover, subjects carrying the miR-499 A allele showed a greatly increased risk of HCC in subjects infected with HBV compared with subjects carrying the miR-499 A allele, with an adjusted odds ratio (95% confidence interval) of 1.53 (1.34-2.41). In conclusion, the miR-146aG>C and miR-499A>G polymorphisms do not have a role in the genetic susceptibility to HCC.
authors: Department of Oncology, Chengdu Military General Hospital, Chengdu, Sichuan Province, China.
authors: D
authors: D
authors: Li
authors: Department of Oncology, Chengdu Military General Hospital, Chengdu, Sichuan Province, China.
authors: J J
authors: JJ
authors: Peng
authors: Department of Oncology, Chengdu Military General Hospital, Chengdu, Sichuan Province, China.
authors: Y
authors: Y
authors: Tan
authors: Department of Oncology, Chengdu Military General Hospital, Chengdu, Sichuan Province, China.
authors: T
authors: T
authors: Chen
authors: Department of Oncology, Chengdu Military General Hospital, Chengdu, Sichuan Province, China.
authors: D
authors: D
authors: Wei
authors: Department of Oncology, Chengdu Military General Hospital, Chengdu, Sichuan Province, China.
authors: M
authors: M
authors: Du
authors: Department of Oncology, Chengdu Military General Hospital, Chengdu, Sichuan Province, China heqiang_cmuc@163.com.
authors: T
authors: T
authors: Zhang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017422:Sequence Analysis, DNA
chemical_list: C542542:MIRN146 microRNA, human; C548683:MIRN499 microRNA, human; D035683:MicroRNAs