title: An instrument dedicated for modelling of pulmonary radiotherapy.
abstract: OBJECTIVE
  Radiotherapy plays a pivotal role in lung cancer treatment. Selection of patients for new (radio)therapeutic options aiming at improving outcomes requires reliable and validated prediction models. We present the implementation of a prospective platform for evaluation and development of lung radiotherapy (proPED-LUNG) as an instrument enabling multidimensional predictive modelling.
  
  
  METHODS
  ProPED-LUNG was designed to comprise relevant baseline and follow up data of patients receiving pulmonary radiotherapy with curative intent. Patient characteristics, diagnostic and staging information, treatment parameters including full dose-volume-histograms, tumour control, survival, and toxicity are scored. Besides physician-rated data, a range of patient-rated data regarding symptoms and health-related quality-of-life are collected.
  
  
  RESULTS
  After 18 months of accrual, 315 patients have been included (accrual rate, 18 per month). Of the first hundred patients included, 70 received conformal (chemo)radiotherapy and 30 underwent stereotactic radiotherapy. Compliance at 3 and 6 months follow-up was 96-100% for patient-rated, and 81-94% for physician-rated assessments. For data collection, 0.4 FTE were allocated in a 183 FTE department (0.2%).
  
  
  CONCLUSIONS
  ProPED-LUNG is feasible with high compliance rates and yields a large amount of high quality prospective disease-related, treatment-related, patient- and physician-rated data which can be used to evaluate new developments in pulmonary radiotherapy.
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands. Electronic address: a.g.h.niezink@umcg.nl.
authors: Anne G H
authors: AG
authors: Niezink
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Nienke J
authors: NJ
authors: Dollekamp
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Harriet J
authors: HJ
authors: Elzinga
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Denise
authors: D
authors: Borger
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Eduard J H
authors: EJ
authors: Boer
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Jan F
authors: JF
authors: Ubbels
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Marleen
authors: M
authors: Woltman-van Iersel
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Annija H D
authors: AH
authors: van der Leest
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Max
authors: M
authors: Beijert
authors: Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Harry J M
authors: HJ
authors: Groen
authors: Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Jan
authors: J
authors: Kraan
authors: Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Thijo J N
authors: TJ
authors: Hiltermann
authors: Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Anthonie J
authors: AJ
authors: van der Wekken
authors: Martini Hospital, Groningen, The Netherlands.
authors: John W G
authors: JW
authors: van Putten
authors: Scheper Hospital, Emmen, The Netherlands.
authors: Steven R
authors: SR
authors: Rutgers
authors: Ommelander Hospital Group, Delfzijl, The Netherlands; Ommelander Hospital Group, Winschoten, The Netherlands.
authors: Remge M
authors: RM
authors: Pieterman
authors: Wilhelmina Hospital, Assen, The Netherlands.
authors: Sander M
authors: SM
authors: de Hosson
authors: Refaja Hospital, Stadskanaal, The Netherlands.
authors: Anke W J
authors: AW
authors: Roenhorst
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Johannes A
authors: JA
authors: Langendijk
authors: Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands.
authors: Joachim
authors: J
authors: Widder
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D011878:Radiotherapy / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods
keywords: Lung cancer; Patient-rated outcome measures; Thoracic radiotherapy