title: Interest in genomic SNP testing for prostate cancer risk: a pilot survey.
abstract: BACKGROUND
  Advancements in genomic testing have led to the identification of single nucleotide polymorphisms (SNPs) associated with prostate cancer. The clinical utility of SNP tests to evaluate prostate cancer risk is unclear. Studies have not examined predictors of interest in novel genomic SNP tests for prostate cancer risk in a diverse population.
  
  
  METHODS
  Consecutive participants in the Fox Chase Prostate Cancer Risk Assessment Program (PRAP) (n = 40) and unselected men from surgical urology clinics (n = 40) completed a one-time survey. Items examined interest in genomic SNP testing for prostate cancer risk, knowledge, impact of unsolicited findings, and psychosocial factors including health literacy.
  
  
  RESULTS
  Knowledge of genomic SNP tests was low in both groups, but interest was higher among PRAP men (p < 0.001). The prospect of receiving unsolicited results about ancestral genomic markers increased interest in testing in both groups. Multivariable modeling identified several predictors of higher interest in a genomic SNP test including higher perceived risk (p = 0.025), indicating zero reasons for not wanting testing (vs ≥1 reason) (p = 0.013), and higher health literacy (p = 0.016).
  
  
  CONCLUSIONS
  Knowledge of genomic SNP testing was low in this sample, but higher among high-risk men. High-risk status may increase interest in novel genomic tests, while low literacy may lessen interest.
authors: Fox Chase Cancer Center, Philadelphia, PA USA.
authors: Michael J
authors: MJ
authors: Hall
authors: Fox Chase Cancer Center, Philadelphia, PA USA.
authors: Karen J
authors: KJ
authors: Ruth
authors: Fox Chase Cancer Center, Philadelphia, PA USA.
authors: David Yt
authors: DY
authors: Chen
authors: Division of Population Science, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA USA.
authors: Laura M
authors: LM
authors: Gross
authors: Division of Population Science, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA USA.
authors: Veda N
authors: VN
authors: Giri
keywords: Genomic testing; Health literacy; Prostate cancer; Risk assessment; Single-nucleotide polymorphism