title: Perspectives on the design of clinical trials for targeted therapies and immunotherapy in veterinary oncology.
abstract: The field of oncology research has undergone major changes in recent years. Progress in molecular and cellular biology has led to a greater understanding of the cellular pathways and mechanisms of cell proliferation and tissue invasion associated with cancer. New classes of cancer therapies are becoming available or are in development but these new agents require a paradigm shift in the design of oncology clinical trials. This review provides an overview of clinical trial designs for the development of tumour vaccines and targeted therapeutic agents. In addition, some of the successes, limitations and challenges of these trials are discussed, with a special emphasis on the difficulties and particularities that are encountered in veterinary medicine compared to similar work in human patients.
authors: Centro Oncologico Veterinario, via San Lorenzo 1-4, 40037 Sasso Marconi (BO), Italy. Electronic address: marconato@centroncologicovet.it.
authors: Laura
authors: L
authors: Marconato
authors: Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2-5, 10095 Grugliasco (TO), Italy.
authors: Paolo
authors: P
authors: Buracco
authors: Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell'Università 16, 35020 Agripolis Legnaro (PD), Italy.
authors: Luca
authors: L
authors: Aresu
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology*; D002986:Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data / Q000662:veterinary*; D007167:Immunotherapy / Q000662:veterinary*; D009369:Neoplasms / Q000517:prevention & control / Q000628:therapy / Q000662:veterinary*; D012107:Research Design
chemical_list: D019496:Cancer Vaccines
keywords: Clinical trials; Endpoints; Immunotherapy; Oncology; Targeted therapy; Veterinary