title: Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction.
abstract: The first copper-catalysed diastereoselective synthesis of P-chiral phosphoramidate prodrugs (ProTides) is reported. This procedure allows the synthesis of diastereomeric-enriched mixtures of ProTides. Application of this methodology to the asymmetric phosphorylation of purine and pyrimidine nucleoside analogues is presented.
authors: School of Pharmacy and Pharmaceutical Sciences, Redwood Building, King Edwards VII Avenue, CF10 3NB, Cardiff, Wales, UK. pertusatif1@cf.ac.uk.
authors: F
authors: F
authors: Pertusati
authors: C
authors: C
authors: McGuigan
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008968:Molecular Conformation; D009705:Nucleosides / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010756:Phosphoric Acids / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D009705:Nucleosides; D009942:Organometallic Compounds; D010756:Phosphoric Acids; D011355:Prodrugs; D003300:Copper; C011067:phosphoramidic acid