title: Polyneuropathy with anti-sulfatide and anti-MAG antibodies: clinical, neurophysiological, pathological features and response to treatment.
abstract: IgM paraproteins often present reactivity to myelin-associated glycoprotein (MAG) and sulfatide. We describe the clinical and neurophysiological findings, and therapy response in 21 patients with IgM paraproteinemic neuropathy (15 with anti-MAG antibodies, 1 with anti-sulfatide antibodies, and 5 with both reactivity), and in 2 with anti-sulfatide positivity and no hematological disease. All patients complained of sensory symptoms, the majority had demyelinating neuropathy. Indirect immunofluorescence on human normal sural nerves disclosed different staining patterns. Eight of 13 patients (6 anti-MAG, 1 anti-sulfatide, 1 both anti-sulfatide and anti-MAG antibodies) improved after Rituximab. IVIg, steroids and plasma-exchange were also administered with different responses.
authors: Department of Neurosciences: Sciences NPSRR, University of Padova, Padova, Italy.
authors: Marta
authors: M
authors: Campagnolo
authors: Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
authors: Sergio
authors: S
authors: Ferrari
authors: Department of Neurosciences: Sciences NPSRR, University of Padova, Padova, Italy.
authors: Chiara
authors: C
authors: Dalla Torre
authors: Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
authors: Ilaria
authors: I
authors: Cabrini
authors: CEMES, EMG Unit, Padova, Italy.
authors: Mario
authors: M
authors: Cacciavillani
authors: Department of Neurosciences: Sciences NPSRR, University of Padova, Padova, Italy.
authors: Marta
authors: M
authors: Lucchetta
authors: Department of Neurosciences: Sciences NPSRR, University of Padova, Padova, Italy.
authors: Susanna
authors: S
authors: Ruggero
authors: Department of Neurosciences: Sciences NPSRR, University of Padova, Padova, Italy.
authors: Elisabetta
authors: E
authors: Toffanin
authors: Department of Neurological and Movement Sciences, University of Verona, Verona, Italy.
authors: Tiziana
authors: T
authors: Cavallaro
authors: Department of Neurosciences: Sciences NPSRR, University of Padova, Padova, Italy. Electronic address: chiara.briani@unipd.it.
authors: Chiara
authors: C
authors: Briani
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D018992:Myelin-Associated Glycoprotein / Q000097:blood*; D011115:Polyneuropathies / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D000069283:Rituximab; D013433:Sulfoglycosphingolipids / Q000097:blood*; D013497:Sural Nerve / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies; D018992:Myelin-Associated Glycoprotein; D013433:Sulfoglycosphingolipids; D000069283:Rituximab
keywords: Demyelinating; Indirect immunofluorescence; Myelin-associated glycoprotein (MAG); Polyneuropathy; Rituximab; Sulfatide