title: Utilizing cardiac biomarkers to detect and prevent chemotherapy-induced cardiomyopathy.
abstract: The success achieved in advances in cancer therapy has been marred by development of cardiotoxicity, which causes significant morbidity and mortality. This has led to the development of surveillance protocols for cardiotoxicity utilizing multimodality imaging techniques and investigation of various drugs to treat and prevent cardiotoxicity in this subset of patients. Cardiac biomarkers hold important diagnostic and prognostic value in various cardiac diseases. In this review, we discuss the use of biomarkers in patients receiving chemotherapy, highlighting data behind the use of troponin, B-type natriuretic peptide, and myeloperoxidase. We also discuss the use of dexrazoxane, angiotensin-converting enzyme inhibitors, and beta blockers in the treatment and prevention of chemotherapy-induced cardiotoxicity. Cardiac biomarkers may serve an important role in selecting patients that are at high risk of cardiotoxicity and can potentially be used to guide the administration of drugs to treat and prevent cardiotoxicity.
authors: Kaufman Center for Heart Failure, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, J3-4, Cleveland, OH, 44195, USA.
authors: Dhssraj
authors: D
authors: Singh
authors: Akanksha
authors: A
authors: Thakur
authors: W H Wilson
authors: WH
authors: Tang
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood*; D006331:Heart Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000517:prevention & control; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood; D009195:Peroxidase / Q000097:blood; D014336:Troponin / Q000097:blood
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D014336:Troponin; D020097:Natriuretic Peptide, Brain; D009195:Peroxidase