title: Biomonitoring Equivalents for interpretation of urinary fluoride.
abstract: Exposure to fluoride is widespread due to its natural occurrence in the environment and addition to drinking water and dental products for the prevention of dental caries. The potential health risks of excess fluoride exposure include aesthetically unacceptable dental fluorosis (tooth mottling) and increased skeletal fragility. Numerous organizations have conducted risk assessments and set guidance values to represent maximum recommended exposure levels as well as recommended adequate intake levels based on potential public health benefits of fluoride exposure. Biomonitoring Equivalents (BEs) are estimates of the average biomarker concentrations corresponding to such exposure guidance values. The literature on daily urinary fluoride excretion rates as a function of daily fluoride exposure was reviewed and BE values corresponding to the available US and Canadian exposure guidance values were derived for fluoride in urine. The derived BE values range from 1.1 to 2.1mg/L (1.2-2.5μg/g creatinine). Concentrations of fluoride in single urinary spot samples from individuals, even under exposure conditions consistent with the exposure guidance values, may vary from the predicted average concentrations by several-fold due to within- and across-individual variation in urinary flow and creatinine excretion rates and due to the rapid elimination kinetics of fluoride. Thus, the BE values are most appropriately applied to screen population central tendency estimates for biomarker concentrations rather than interpretation of individual spot sample concentrations.
authors: Summit Toxicology, LLP, Falls Church, VA, USA.
authors: L L
authors: LL
authors: Aylward
authors: Summit Toxicology, LLP, Lyons, CO, USA. Electronic address: shays@summittoxicology.com.
authors: S M
authors: SM
authors: Hays
authors: Health Canada, Ottawa, ON, Canada.
authors: A
authors: A
authors: Vezina
authors: Health Canada, Ottawa, ON, Canada.
authors: M
authors: M
authors: Deveau
authors: Health Canada, Ottawa, ON, Canada.
authors: A
authors: A
authors: St-Amand
authors: Health Canada, Ottawa, ON, Canada.
authors: A
authors: A
authors: Nong
mesh_terms: D015415:Biomarkers / Q000652:urine; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods; D005459:Fluorides / Q000652:urine*; D006801:Humans; D011634:Public Health; D018570:Risk Assessment
chemical_list: D015415:Biomarkers; D005459:Fluorides
keywords: Biomonitoring; Biomonitoring Equivalents; Fluoride; Risk assessment