title: Clinicopathologic features of 112 cases with mantle cell lymphoma.
abstract: OBJECTIVE
  This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL).
  
  
  METHODS
  Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test was used in the statistical analysis.
  
  
  RESULTS
  All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was observed in 2 classic cases.
  
  
  CONCLUSIONS
  MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.
authors: Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.
authors: Dong-Mei
authors: DM
authors: Zhou
authors: Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.
authors: Gang
authors: G
authors: Chen
authors: Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.
authors: Xiong-Wei
authors: XW
authors: Zheng
authors: Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.
authors: Wei-Feng
authors: WF
authors: Zhu
authors: Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.
authors: Bao-Zhen
authors: BZ
authors: Chen
keywords: Mantle cell lymphoma (MCL); fluorescence in situ hybridization (FISH); immunohistochemistry; prognosis