title: Behavioral disturbances in estrogen-related receptor alpha-null mice.
abstract: Eating disorders, such as anorexia nervosa and bulimia nervosa, are common and severe mental illnesses of unknown etiology. Recently, we identified a rare missense mutation in the transcription factor estrogen-related receptor alpha (ESRRA) that is associated with the development of eating disorders. However, little is known about ESRRA function in the brain. Here, we report that Esrra is expressed in the mouse brain and demonstrate that Esrra levels are regulated by energy reserves. Esrra-null female mice display a reduced operant response to a high-fat diet, compulsivity/behavioral rigidity, and social deficits. Selective Esrra knockdown in the prefrontal and orbitofrontal cortices of adult female mice recapitulates reduced operant response and increased compulsivity, respectively. These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains.
authors: Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
authors: Huxing
authors: H
authors: Cui
authors: Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
authors: Yuan
authors: Y
authors: Lu
authors: Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
authors: Michael Z
authors: MZ
authors: Khan
authors: Department of Psychology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
authors: Rachel M
authors: RM
authors: Anderson
authors: Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
authors: Latisha
authors: L
authors: McDaniel
authors: Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
authors: Hannah E
authors: HE
authors: Wilson
authors: Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
authors: Terry C
authors: TC
authors: Yin
authors: Department of Psychology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Program, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
authors: Jason J
authors: JJ
authors: Radley
authors: Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA; Department of Neurology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Program, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA.
authors: Andrew A
authors: AA
authors: Pieper
authors: Department of Psychiatry, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA; Interdisciplinary Neuroscience Program, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA. Electronic address: michael-lutter@uiowa.edu.
authors: Michael
authors: M
authors: Lutter
mesh_terms: D000818:Animals; D000856:Anorexia Nervosa / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D059305:Diet, High-Fat; D005260:Female; D007150:Immunohistochemistry; D001523:Mental Disorders / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011960:Receptors, Estrogen / Q000378:metabolism*; D000097983:ERRalpha Estrogen-Related Receptor
chemical_list: D011960:Receptors, Estrogen; D000097983:ERRalpha Estrogen-Related Receptor