title: Overwhelming postsplenectomy infection.
abstract: This report aims to deepen the understanding of the pathogenesis, diagnosis, clinical characteristics, and treatment of overwhelming postsplenectomy infection (OPSI). A patient treated at Taihe Hospital for tuberculous OPSI is described, and relevant literature is reviewed. Broad-spectrum antibiotics, suppression of the systemic inflammatory reaction, and anti-shock measures were the keys to the successful treatment of this condition. OPSI is a life-threatening condition and has a high mortality rate. Early diagnosis, use of anti-inflammatory glucocorticoids, and administration of high-dose gamma globulin and ulinastatin for the treatment of OPSI may improve outcomes.
authors: Department of Intensive Care Medicine, Taihe Hospital, Shiyan, China.
authors: C-F
authors: CF
authors: Sheng
authors: Department of Intensive Care Medicine, Taihe Hospital, Shiyan, China.
authors: B-Y
authors: BY
authors: Liu
authors: Department of Intensive Care Medicine, Taihe Hospital, Shiyan, China.
authors: H-M
authors: HM
authors: Zhang
authors: Department of Intensive Care Medicine, Taihe Hospital, Shiyan, China xiangzhengcn@yeah.net.
authors: X
authors: X
authors: Zheng
mesh_terms: D000307:Adrenal Gland Diseases / Q000175:diagnosis / Q000209:etiology; D000311:Adrenal Glands / Q000098:blood supply; D000328:Adult; D003937:Diagnosis, Differential; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007239:Infections / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D013156:Splenectomy / Q000009:adverse effects*; D014376:Tuberculosis / Q000175:diagnosis* / Q000209:etiology