title: Receptors, ion channels, and signaling mechanisms underlying microglial dynamics.
abstract: Microglia, the innate immune cells of the CNS, play a pivotal role in brain injury and disease. Microglia are extremely motile; their highly ramified processes constantly survey the brain parenchyma, and they respond promptly to brain damage with targeted process movement toward the injury site. Microglia play a key role in brain development and function by pruning synapses during development, phagocytosing apoptotic newborn neurons, and regulating neuronal activity by direct microglia-neuron or indirect microglia-astrocyte-neuron interactions, which all depend on their process motility. This review highlights recent discoveries about microglial dynamics, focusing on the receptors, ion channels, and signaling pathways involved.
authors: From the Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom c.madry@ucl.ac.uk.
authors: Christian
authors: C
authors: Madry
authors: From the Department of Neuroscience, Physiology & Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom.
authors: David
authors: D
authors: Attwell
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D001253:Astrocytes / Q000276:immunology / Q000473:pathology; D001930:Brain Injuries / Q000276:immunology* / Q000473:pathology; D002450:Cell Communication / Q000276:immunology; D002465:Cell Movement / Q000276:immunology*; D006801:Humans; D007473:Ion Channels / Q000276:immunology*; D017628:Microglia / Q000276:immunology* / Q000473:pathology; D009474:Neurons / Q000276:immunology / Q000473:pathology; D010587:Phagocytosis; D011956:Receptors, Cell Surface / Q000276:immunology*; D013569:Synapses / Q000276:immunology / Q000473:pathology
chemical_list: D007473:Ion Channels; D011956:Receptors, Cell Surface
keywords: ADP; ATP; microglia; neuroimmunology; synapse