title: Sudden hearing loss due to oxaliplatin use in a patient with colon cancer.
abstract: Oxaliplatin is used to treat advanced colorectal cancer. Platinum-containing chemotherapeutic agents are known to be ototoxic. However, ototoxicity is rare with newer generation platinum-derived agents, such as oxaliplatin. This case report presents a rare case of sudden unilateral sensorineural hearing loss following intravenous (IV) infusion of oxaliplatin in a 64-year-old woman with advanced colon cancer. The hearing loss was severe and did not respond to treatment. To the best of our knowledge, this is the fifth reported case of oxaliplatin ototoxicity. Although oxaliplatin ototoxicity is rare, physicians must be aware of this important adverse effect, and an audiometric evaluation must be performed when necessary. Patients treated with oxaliplatin should be followed closely for early signs and symptoms of hearing loss, and if hearing loss is detected, treatment should be stopped immediately.
authors: a Acibadem University, Medical Faculty, Department of Otorhinolaryngology , İstanbul , Turkey.
authors: M Güven
authors: MG
authors: Güvenç
authors: b Gaziosmanpaşa Taksim Education and Research Hospital, Department of Otorhinolaryngology , İstanbul , Turkey.
authors: Denizhan
authors: D
authors: Dizdar
authors: c Hamidiye Şişli Etfal Education and Research Hospital, Department of Otorhinolaryngology , İstanbul , Turkey.
authors: Senem Kurt
authors: SK
authors: Dizdar
authors: d Acibadem University, Medical Faculty, Department of Medical Oncology , İstanbul , Turkey.
authors: Sadi Kerem
authors: SK
authors: Okutur
authors: d Acibadem University, Medical Faculty, Department of Medical Oncology , İstanbul , Turkey.
authors: Gökhan
authors: G
authors: Demir
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000150:complications* / Q000188:drug therapy; D005260:Female; D003639:Hearing Loss, Sudden / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin
keywords: Ototoxicity; Oxaliplatin; Sudden sensorineural hearing loss