title: Type 2 diabetes mellitus and atrial fibrillation: From mechanisms to clinical practice.
abstract: Type 2 diabetes mellitus is one of the most common chronic conditions and its prevalence has increased continuously over the past decades, primarily due to the obesity epidemic. Atrial fibrillation (AF) is the most frequent sustained cardiac arrhythmia in clinical practice and is associated with increased cardiovascular and cerebrovascular morbidity and mortality. Recent studies have shown that patients with diabetes have an increased risk of AF. However, the results about the relationship between diabetes and AF are still conflicting. Mechanisms that are responsible for an association between diabetes and AF, as well as the adequate treatment of AF in patients with diabetes, are still insufficiently studied. The aim of this review is to summarize the current knowledge of mechanisms that connect AF and diabetes, the clinical studies that include patients with both conditions, and the treatment options in modern pharmacology.
authors: University Clinical Hospital Centre "Dr. Dragisa Misovic - Dedinje", Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia. Electronic address: marijana_tadic@hotmail.com.
authors: Marijana
authors: M
authors: Tadic
authors: Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano, Meda, Italy.
authors: Cesare
authors: C
authors: Cuspidi
mesh_terms: D000200:Action Potentials; D000818:Animals; D001281:Atrial Fibrillation / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D064752:Atrial Remodeling; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D017115:Catheter Ablation; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D006329:Heart Conduction System / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015995:Prevalence; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents
keywords: Atrial fibrillation; Clinical studies; Fibrillation atriale; Mechanisms; Mécanismes; Traitement; Treatment; Type 2 diabetes mellitus; Études cliniques