title: Calcium phosphate/microgel composites for 3D powderbed printing of ceramic materials.
abstract: Composites of microgels and calcium phosphates are promising as drug delivery systems and basic components for bone substitute implants. In this study, we synthesized novel composite materials consisting of pure β-tricalcium phosphate and stimuli-responsive poly(N-vinylcaprolactam-co-acetoacetoxyethyl methacrylate-co-vinylimidazole) microgels. The chemical composition, thermal properties and morphology for obtained composites were extensively characterized by Fourier transform infrared, X-ray photoelectron spectroscopy, IGAsorp moisture sorption analyzer, thermogravimetric analysis, granulometric analysis, ESEM, energy dispersive X-ray spectroscopy and TEM. Mechanical properties of the composites were evaluated by ball-on-three-balls test to determine the biaxial strength. Furthermore, initial 3D powderbed-based printing tests were conducted with spray-dried composites and diluted 2-propanol as a binder to evaluate a new binding concept for β-tricalcium phosphate-based granulates. The printed ceramic bodies were characterized before and after a sintering step by ESEM. The hypothesis that the microgels act as polymer adhesive agents by efficient chemical interactions with the β-tricalcium phosphate particles was confirmed. The obtained composites can be used for the development of new scaffolds.
authors: Mandy-Nicole
authors: MN
authors: Birkholz
authors: Garima
authors: G
authors: Agrawal
authors: Christian
authors: C
authors: Bergmann
authors: Ricarda
authors: R
authors: Schröder
authors: Sebastian J
authors: SJ
authors: Lechner
authors: Andrij
authors: A
authors: Pich
authors: Horst
authors: H
authors: Fischer
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry; D002130:Calcium Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems; D008689:Methacrylates / Q000138:chemical synthesis* / Q000737:chemistry; D019736:Prostheses and Implants / Q000592:standards; D023822:Tissue Engineering / Q000379:methods*; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D008689:Methacrylates; D014753:Vinyl Compounds; C000621616:poly(N-vinylcaprolactam-co-acetoacetoxyethyl methacrylate-co-vinylimidazole)