title: Overlap between dermatomyositis and ANCA vasculitides.
abstract: We present the second report of the association between antineutrophil cytoplasm antibodies (ANCA)-associated vasculitis with dermatomyositis (DM). A 47-year-old woman suddenly developed rapidly progressive renal failure in the context of (DM). The kidney biopsy showed focal and segmental necrotizing glomerulonephritis with crescent formation. Cyclophosphamide treatment was commenced resulting in a significant recovery of kidney function and maintenance of recovery at 6 months. Although the pathophysiology is unknown, we hypothesize that CD8-T-deficient cells and MPO+ neutrophils in the DM lesions play an important role in the disease process.
authors: Shrewsbury and Telford NHS Trust , Shorpshire , UK.
authors: Claudia
authors: C
authors: Yuste
authors: Shrewsbury and Telford NHS Trust , Shorpshire , UK.
authors: Molefe
authors: M
authors: Rapalai
authors: Shrewsbury and Telford NHS Trust , Shorpshire , UK.
authors: Benjamin A
authors: BA
authors: Pritchard
authors: Shrewsbury and Telford NHS Trust , Shorpshire , UK.
authors: Terence J
authors: TJ
authors: Jones
authors: Shrewsbury and Telford NHS Trust , Shorpshire , UK.
authors: Constanza
authors: C
authors: Amoasii
authors: Shrewsbury and Telford NHS Trust , Shorpshire , UK.
authors: Atheer
authors: A
authors: Al-Ansari
authors: Shrewsbury and Telford NHS Trust , Shorpshire , UK.
authors: Satish B
authors: SB
authors: Ramakrishna
keywords: ANCA vasculitis; dermatomyositis; focal and segmental necrotizing glomerulonephritis; microscopic polyangiitis; vasculitis