title: A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease.
abstract: The potential risk factors for congenital cytomegalovirus (cCMV) infection or development of disease remain unclear. Here, we investigated the genetic polymorphisms in natural killer (NK) group 2, member D (NKG2D), an activating receptor expressed on NK cells, and in MHC class I-related chains A, the ligand of NKG2D, in 87 cCMV cases, and found that there was a significant association between cCMV disease and a single nucleotide polymorphism, Thr72Ala, in NKG2D.
authors: Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
authors: Rumi
authors: R
authors: Taniguchi
authors: Shin
authors: S
authors: Koyano
authors: Tatsuo
authors: T
authors: Suzutani
authors: Keiji
authors: K
authors: Goishi
authors: Yushi
authors: Y
authors: Ito
authors: Ichiro
authors: I
authors: Morioka
authors: Hiroyuki
authors: H
authors: Nakamura
authors: Hideto
authors: H
authors: Yamada
authors: Akira
authors: A
authors: Oka
authors: Naoki
authors: N
authors: Inoue
mesh_terms: D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000235:genetics / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D020125:Mutation, Missense; D055655:NK Cell Lectin-Like Receptor Subfamily K / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies
chemical_list: C527085:KLRK1 protein, human; D055655:NK Cell Lectin-Like Receptor Subfamily K