title: Synthesis and antimicrobial properties of N-substituted derivatives of (E)-2',3″-thiazachalcones.
abstract: N-alkyl substituted 2',3″-thiazachalcones {3-[(1E)-3-(4-methylthiophene-2-yl)-3-oxoprop-1-en-1-yl]-1-alkyl (C5-12,14) pyridinium bromides} were synthesized by a two-step reaction. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectral studies. The synthesized compounds were tested for antibacterial activities and found to be more active against Gram-positive as compared to Gram-negative bacteria.
authors: Asu
authors: A
authors: Usta
authors: Hacer
authors: H
authors: Taşkıran
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D047188:Chalcones / Q000138:chemical synthesis* / Q000494:pharmacology*; D055808:Drug Discovery; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D066244:Proton Magnetic Resonance Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D047188:Chalcones