title: Evaluation of serum & salivary IgA in patients with type 1 diabetes.
abstract: BACKGROUND
  Diabetes mellitus is a common immune mediated disorder. The aim of the present study is to evaluate the level of serum and salivary IgA levels in patients with Type 1 diabetes.
  
  
  METHODS
  In this case control study, serum and salivary IgA levels of patients with diabetes type 1 and similar non diabetes subjects were measured. Age, gender, duration of diabetes and the last HbA1c level of diabetic patients were also studied. Data was analyzed by SPSS software.
  
  
  RESULTS
  Two hundred and fifty subjects (126 diabetics and 124 non diabetics) were enrolled in the study. The mean value of serum IgA in patients with Type 1 Diabetes and controls was 1.77± 1.55 g/lit and 2.39± 1.52 g/lit, respectively. The mean salivary IgA level in diabetics and controls was 276 ± 162.5 40 μg/ml and 129 ± 112.2 40 μg/ml, respectively. Selective IgA deficiency was detected in two (1.6%) and three(2.4%)cases of diabetic and control group; respectively (p=0.68). We found low salivary IgA level in 44.4% diabetic and 33.9% control (p=0.08). There was no significant correlation between serum and salivary IgA level. There was also significant association between serum IgA levels with age. Salivary IgA was significantly correlated with HbA1c level. But considering gender, duration of diabetes we didn't find any association.
  
  
  CONCLUSIONS
  We didn't find any significant difference in serum and salivary IgA level among diabetic and non diabetics and also, no association between serum and salivary IgA levels.
authors: Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
authors: Akefeh
authors: A
authors: Ahmadiafshar
authors: Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
authors: Mahmood Reza
authors: MR
authors: Mohsenifard
authors: Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
authors: Saeideh
authors: S
authors: Mazloomzadeh
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000276:immunology / Q000378:metabolism; D006801:Humans; D017098:IgA Deficiency / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D007070:Immunoglobulin A / Q000378:metabolism*; D008297:Male; D012463:Saliva / Q000737:chemistry / Q000276:immunology; D012737:Sex Factors
chemical_list: D006442:Glycated Hemoglobin; D007070:Immunoglobulin A; C517652:hemoglobin A1c protein, human