title: Prospective randomized trial: outcomes of SF₆ versus C₃F₈ in macular hole surgery.
abstract: OBJECTIVE
  To compare macular hole (MH) closure and visual acuity improvement after vitrectomy using SF6 versus C3F8 gas tamponade. The secondary purposes were to report the cumulative incidence of cataract development at 1 year after MH surgery and the proportion of complications.
  
  
  METHODS
  Prospective, randomized study.
  
  
  METHODS
  Thirty-one patients were prospectively randomized to the SF6 group and 28 patients to the C3F8 group.
  
  
  METHODS
  Preoperative data included MH minimum diameter, Early Treatment Diabetic Retinopathy Study (ETDRS) best corrected visual acuity (BCVA), cataract staging, and intraocular pressure (IOP) measurement. Postoperative data included optical coherence tomography confirmation of the closure at 6 weeks and 1 year, and ETDRS BCVA and cataract development/extraction, both 1 year after the MH surgery.
  
  
  RESULTS
  Primary MH closure was achieved in 93.3% in the SF6 group and 92.9% in the C3F8 group. Mean ETDRS BCVA improved by 17.7 letters in the SF6 and 16.9 letters in the C3F8 group. The difference in cumulative incidence of cataract development and extraction between both groups was not statistically significant. Regardless of the dye used, similar results were achieved. Finally, the proportion of adverse events was similar in both groups.
  
  
  CONCLUSIONS
  MH surgery with SF6 gas achieves results similar to C3F8 in terms of visual acuity improvement, MH closure, cataract development/extraction, and adverse events.
authors: Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval. Electronic address: sophiebriand@hotmail.com.
authors: Sophie
authors: S
authors: Briand
authors: Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval.
authors: Emmanuelle
authors: E
authors: Chalifoux
authors: Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval; CUO-Recherche, Centre de Recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec.
authors: Eric
authors: E
authors: Tourville
authors: Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval; CUO-Recherche, Centre de Recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec.
authors: Serge
authors: S
authors: Bourgault
authors: Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval; CUO-Recherche, Centre de Recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec.
authors: Mathieu
authors: M
authors: Caissie
authors: Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval; CUO-Recherche, Centre de Recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec.
authors: Yvon
authors: Y
authors: Tardif
authors: Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval; CUO-Recherche, Centre de Recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec.
authors: Marcelle
authors: M
authors: Giasson
authors: Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval; CUO-Recherche, Centre de Recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec.
authors: Jocelyne
authors: J
authors: Boivin
authors: Axe Santé des Populations et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec, Quebec, Que.
authors: Caty
authors: C
authors: Blanchette
authors: Centre Universitaire d'Ophtalmologie, Hôpital du Saint-Sacrement, CHU de Québec, Quebec, Que; Département d'Ophtalmologie, Faculté de Médecine, Université Laval; CUO-Recherche, Centre de Recherche du CHU de Québec, Hôpital du Saint-Sacrement, CHU de Québec.
authors: Benoit
authors: B
authors: Cinq-Mars
mesh_terms: D000368:Aged; D002386:Cataract / Q000139:chemically induced; D058450:Endotamponade; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012167:Retinal Perforations / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D013459:Sulfur Hexafluoride / Q000008:administration & dosage* / Q000009:adverse effects; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy
chemical_list: D005466:Fluorocarbons; C042852:perflutren; D013459:Sulfur Hexafluoride