title: An adaptive biointerface from self-assembled functional peptides for tissue engineering.
abstract: A self-assembled peptide-based biointerface is demonstrated with triple functional layers that can significantly improve the tissue self-healing process or prevent biofilm-mediated chronic inflammation. This smart biointerface is composed of three functional moieties (i.e., a cell-adhesive peptide, an infectious environment-responsive peptide, and an antifouling hexaethylene glycol (HEG) layer), and the resulting interface coated onto prosthetic replacements can smartly respond to the surrounding physiological or pathological microenvironment.
authors: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors: Li-Li
authors: LL
authors: Li
authors: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.|Key Lab for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 693 Xiongchu Ave., Wuhan, 430073, China.
authors: Guo-Bin
authors: GB
authors: Qi
authors: Key Lab for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, 693 Xiongchu Ave., Wuhan, 430073, China.
authors: Faquan
authors: F
authors: Yu
authors: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors: Shi-Jie
authors: SJ
authors: Liu
authors: Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.
authors: Hao
authors: H
authors: Wang
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D057219:Biofouling / Q000517:prevention & control; D002448:Cell Adhesion; D002452:Cell Count; D003030:Coagulase / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli; D005026:Ethylene Glycols / Q000737:chemistry; D005347:Fibroblasts / Q000502:physiology; D018093:Gelatinases / Q000235:genetics / Q000378:metabolism; D016023:Integrins / Q000737:chemistry; D051379:Mice; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D011514:Proteus vulgaris; D011550:Pseudomonas aeruginosa; D012706:Serratia marcescens; D012825:Silicon / Q000737:chemistry; D013211:Staphylococcus aureus; D013212:Staphylococcus epidermidis; D023822:Tissue Engineering / Q000295:instrumentation* / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D003030:Coagulase; D005026:Ethylene Glycols; D016023:Integrins; D010455:Peptides; C077067:hexaethylene glycol; D018093:Gelatinases; D012825:Silicon
keywords: anti-biofilms; functional peptides; self-assembly; self-healing; tissue engineering