title: Topical Imiquimod in the Treatment of Conjunctival Actinic Keratosis.
abstract: Conjunctival actinic keratosis is rare and difficult to treat, as recurrences are common. Imiquimod, an immune response modulator, is currently Food and Drug Administration-approved for cutaneous actinic keratosis and superficial basal cell carcinomas. Emerging reports have shown it to be effective in treating some periocular and conjunctival lesions. The authors present a case of a 68-year-old white man with recurrent actinic keratosis involving the pretarsal conjunctiva, which was successfully treated with 5% topical imiquimod following previous failure with cryotherapy and interferon α-2b. The patient had ocular irritation that resolved on cessation of treatment. To the authors' knowledge, this is the first report of conjunctival actinic keratosis being treated with and successfully eradicated by topical imiquimod.
authors: *Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut; †Morgenstern Center for Orbital and Facial Plastic Surgery, Wayne, Pennsylvania; ‡Oculofacial Plastic Surgeons of Georgia, Atlanta, Georgia; and §Department of Ophthalmic Oncology, Smilow Cancer Hospital, Yale University School of Medicine, New Haven, Connecticut, U.S.A.
authors: Megan A
authors: MA
authors: Rowlands
authors: Joseph N
authors: JN
authors: Giacometti
authors: Javier
authors: J
authors: Servat
authors: Miguel A
authors: MA
authors: Materin
authors: Flora
authors: F
authors: Levin
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000287:Administration, Topical; D000368:Aged; D000634:Aminoquinolines / Q000008:administration & dosage*; D003229:Conjunctival Diseases / Q000188:drug therapy*; D006801:Humans; D000077271:Imiquimod; D055623:Keratosis, Actinic / Q000188:drug therapy*; D008297:Male; D016896:Treatment Outcome
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000077271:Imiquimod