title: Correlation analysis of the PNPLA7 gene polymorphism and susceptibility to menstrual disorder.
abstract: We examined the correlation between PNPLA7 gene polymorphisms at the rs61754920 and rs11137410 loci and menstrual disorder in women of reproductive age in the Central Plain. Genomic DNA was extracted from peripheral blood; polymerase chain reaction-ligase detection reaction and SNaPshot genotyping were used to detect polymorphisms in the rs61754920 and rs11137410 gene loci, respectively. The results for the 2 loci in individuals of different blood types were statistically analyzed. The proportion of the AA homozygote at the rs61754920 locus in the PNPLA7 gene was the lowest, while the proportion of the CC homozygote at the rs11137410 locus in the PNPLA7 gene was the highest. There were no statistical differences in the frequency distribution of genotypes and alleles at the 2 loci between control and test groups. The frequency of the TT genotype at the rs11137410 locus in women with type O blood was significantly lower in the test group than in the control group. Frequencies of the C and T alleles were significantly different between the 2 groups. There may be an association between the PNPLA7 gene and type O blood or a combined effect of the 2 genes.
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China.
authors: Y
authors: Y
authors: Su
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China.
authors: G L
authors: GL
authors: Kong
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China.
authors: Y L
authors: YL
authors: Su
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China.
authors: Y
authors: Y
authors: Zhou
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China yongsudoc@163.com.
authors: L F
authors: LF
authors: Lv
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China.
authors: Q
authors: Q
authors: Wang
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China.
authors: B P
authors: BP
authors: Huang
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China.
authors: R Z
authors: RZ
authors: Zheng
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China.
authors: Q Z
authors: QZ
authors: Li
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China.
authors: H J
authors: HJ
authors: Yuan
authors: Department of Endocrinology, The People's Hospital (Henan Provincial People's Hospital), Zhengzhou University, Zhengzhou, China.
authors: Z G
authors: ZG
authors: Zhao
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008245:Lysophospholipase; D008597:Menstrual Cycle / Q000235:genetics; D008599:Menstruation Disturbances / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D000017:ABO Blood-Group System; D008049:Lipase; D008245:Lysophospholipase; C000604865:PNPLA7 protein, human