title: Diagnostic characteristics and metabolic risk factors of cases with polycystic ovary syndrome during adolescence.
abstract: OBJECTIVE
  Polycystic ovary syndrome (PCOS) is a disorder without definite consensus on its diagnosis and management during adolescence. According to Amsterdam-2012 consensus, as physiological characteristics of adolescence may overlap with PCOS signs, it has been indicated that all Rotterdam criteria should be met. In this present study, characteristics of adolescents with different phenotypes who were diagnosed with PCOS were evaluated; and presence of differences for metabolic risk factors between phenotypes were investigated.
  
  
  METHODS
  The study was performed on adolescent females. According to phenotypic application models, individuals with all Rotterdam diagnostic criteria [hyperandrogenism (HA), polycystic ovarian morphology (PCOM), and chronic anovulation (CA) on the ultrasonography] were in Group 1 (n = 26); with HA and CA were in Group 2 (n = 10); with HA and PCOM were in Group 3 (n = 7); and with CA and PCOM were in Group 4 (n = 10).
  
  
  RESULTS
  The most common application complaint (87%) among 53 cases enrolled in the study was menstrual irregularities, and 57% of cases were not obese. When PCOS was evaluated according to phenotypes, it was realized that cases that meet all 3 diagnostic Rotterdam criteria according to the current recommendation in adolescents. (Group 1) was the most common phenotype. Hyperandrogenism was associated with more metabolic abnormalities.
  
  
  CONCLUSIONS
  The close monitoring of adolescents, who have 2 diagnostic criteria is advisable among PCOS phenotypes. Potentially Groups 2 and 3 which have hyperandrogenism, in particular should warrant closer follow-up although they do not meet current diagnostic criteria for adolescents.
authors: Department of Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey. Electronic address: zeynepsklr@gmail.com.
authors: Zeynep
authors: Z
authors: Sıklar
authors: Department of Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey.
authors: Merih
authors: M
authors: Berberoğlu
authors: Department of Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey.
authors: Emine
authors: E
authors: Çamtosun
authors: Department of Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey.
authors: Pınar
authors: P
authors: Kocaay
mesh_terms: D000293:Adolescent; D000858:Anovulation / Q000209:etiology; D002648:Child; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000175:diagnosis*; D012307:Risk Factors; D014421:Turkey
keywords: Adolescents; Diagnosis; Polycystic ovary syndrome