title: Long-term effect of molsidomine, a direct nitric oxide donor, as an add-on treatment, on endothelial dysfunction in patients with stable angina pectoris undergoing percutaneous coronary intervention: results of the MEDCOR trial.
abstract: OBJECTIVE
  The MEDCOR trial is a double-blind, randomized study aiming at demonstrating the superiority of molsidomine (direct NO donor) over placebo, used as add-on treatments, on improving endothelial function (EF) after 12 months, in stable angina patients undergoing percutaneous coronary intervention.
  
  
  METHODS
  EF was assessed by peripheral vasodilator response (i.e. Endoscore) using arterial tonometry and by several biomarkers, in terms of changes versus baseline after a one-year treatment.
  
  
  RESULTS
  The change in Endoscore was +75 ± 130% in placebo group and +39 ± 145% in molsidomine group (p = 0.143). There was a decrease in sICAM-1 with molsidomine (-6%) and an increase with placebo (+6%). The MPO activity/antigen ratio slightly increased with placebo (+9%) and strongly decreased with molsidomine (-42%) (p = 0.020).
  
  
  CONCLUSIONS
  The MEDCOR trial was not able to demonstrate significant differences between molsidomine and placebo for all parameters, except the MPO activity/antigen ratio which significantly decreased with molsidomine (p = 0.020 versus placebo).
authors: Cardiovascular Research Center Aalst, OLV Clinic, Aalst, Belgium; Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy. Electronic address: emanuele.barbato@olvz-aalst.be.
authors: Emanuele
authors: E
authors: Barbato
authors: Berchem, Belgium.
authors: Arnold
authors: A
authors: Herman
authors: Jessa Hospital, Campus Virga Jesse, Hasselt, Belgium.
authors: Edouard
authors: E
authors: Benit
authors: Imelda Hospital, Bonheiden, Belgium.
authors: Luc
authors: L
authors: Janssens
authors: CHU Charleroi, Charleroi, Belgium.
authors: Jacques
authors: J
authors: Lalmand
authors: CHR Citadelle, Liège, Belgium.
authors: Etienne
authors: E
authors: Hoffer
authors: CHU Dinant Godinne UCL Namur, Yvoir, Belgium.
authors: Patrick
authors: P
authors: Chenu
authors: CHU Dinant Godinne UCL Namur, Yvoir, Belgium.
authors: Antoine
authors: A
authors: Guédès
authors: Saint-Jan Hospital, Bruges, Belgium.
authors: Luc
authors: L
authors: Missault
authors: Saint-Pierre Hospital, Ottignies, Belgium.
authors: Bruno
authors: B
authors: Pirenne
authors: Saint-Pierre Hospital, Ottignies, Belgium.
authors: François
authors: F
authors: Cardinal
authors: Saint-Jean Hospital, Brussels, Belgium.
authors: Steven
authors: S
authors: Vercauteren
authors: Cardiovascular Research Center Aalst, OLV Clinic, Aalst, Belgium.
authors: William
authors: W
authors: Wijns
mesh_terms: D000368:Aged; D060050:Angina, Stable / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D001530:Belgium; D015415:Biomarkers / Q000097:blood; D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008365:Manometry; D008875:Middle Aged; D008981:Molsidomine / Q000009:adverse effects / Q000627:therapeutic use*; D020030:Nitric Oxide Donors / Q000009:adverse effects / Q000627:therapeutic use*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects; D009195:Peroxidase / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers; C573420:ICAM1 protein, human; D020030:Nitric Oxide Donors; D014665:Vasodilator Agents; D018799:Intercellular Adhesion Molecule-1; D008981:Molsidomine; D009195:Peroxidase
keywords: Atherosclerosis; Biomarkers; Molsidomine; Nitric oxide donor; Percutaneous coronary intervention; Reactive hyperemia-peripheral arterial tonometry; Stable angina