title: Adoptive T-cell therapy in the treatment of viral and opportunistic fungal infections.
abstract: Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely different strategies. This review describes the potential of several T-cell-based therapeutic approaches in the prophylaxis and treatment of infectious diseases with a particular focus on persistent viral infections and opportunistic fungal infections, as these mostly affect immunocompromised patients.
authors: Laboratorio di Microbiologia e Virologia, Università 'Vita-Salute' San Raffaele, DIBIT2, via Olgettina 58, 20132, Milan, Italy.
authors: Nicasio
authors: N
authors: Mancini
authors: Lara
authors: L
authors: Marrone
authors: Nicola
authors: N
authors: Clementi
authors: Giuseppe A
authors: GA
authors: Sautto
authors: Massimo
authors: M
authors: Clementi
authors: Roberto
authors: R
authors: Burioni
mesh_terms: D019264:Adoptive Transfer; D006801:Humans; D016867:Immunocompromised Host; D009181:Mycoses / Q000628:therapy*; D009894:Opportunistic Infections / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000628:therapy*
keywords: T cell; T-cell receptor; adoptive T-cell therapy; chimeric antigen receptor; fungal infections; immunocompromised patients; infectious diseases; viral infections