title: Emerging role of post-translational modifications in chronic kidney disease and cardiovascular disease.
abstract: Post-translational modifications (PTMs) of proteins and peptides have recently gained much attention, as they are involved in the pathogenesis of cardiovascular disease and eventually also play a role in the progression of chronic kidney disease (CKD). In this review, we provide an overview of post-translational protein modifications such as carbamylation, glycation and oxidation, starting with their definitions, mechanisms and clinical relevance in the setting of CKD and cardiovascular disease. The methods currently used for the identification and, in particular, quantification of PTMs are described and potential treatment options in the context of PTMs are reviewed. We foresee that advancements in mass spectrometry-based methods leading to the identification of novel disease markers and/or pathophysiologically relevant factors will certainly boost the clinical utility in sample analyses.
authors: Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen, Aachen, Germany.
authors: Prathibha R
authors: PR
authors: Gajjala
authors: Department of Internal Medicine 4, Saarland University Hospital, Homburg/Saar, Germany.
authors: Danilo
authors: D
authors: Fliser
authors: Department of Internal Medicine 4, Saarland University Hospital, Homburg/Saar, Germany.
authors: Thimoteus
authors: T
authors: Speer
authors: Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen, Aachen, Germany.
authors: Vera
authors: V
authors: Jankowski
authors: Institute for Molecular Cardiovascular Research (IMCAR), University Hospital RWTH Aachen, Aachen, Germany.
authors: Joachim
authors: J
authors: Jankowski
mesh_terms: D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy
chemical_list: D011506:Proteins
keywords: carbamylation; cardiovascular disease; chronic kidney disease; oxidation; post-translational modification