title: [The laboratory evaluation of pathogenic factors under retarded consolidation of fractures of bones of lower extremities].
abstract: The study was carried out to comparatively analyze metabolic profile and content of growth factors in blood serum of patients with retarded consolidation of fractures of bones of lower extremities. The evaluation was applied to concentration of metabolites, growth factors and enzyme activity of blood serum in 13 patients with retarded consolidation of fractures of thigh and shank bones (main group). The comparative group included 14 patients with solid fractures of thigh and shank bones. The analysis established that as compared to patients with solid fractures of bones, in patients with retarded consolidation of fractures blood serum contained reliably higher concentration of triglycerides, products of glycolysis, epidermal growth factor and transforming growth factors TGF-α and TGF-β2. The content of vitamin E and insullin-like growth factor (IGF-1) was decreased The given markers can be labeled as potential markers of diagnostic and prognosis of development of retarded consolidation of fractures.
authors: V M
authors: VM
authors: Stogov
authors: E A
authors: EA
authors: Kireeva
authors: A G
authors: AG
authors: Karasev
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D005260:Female; D050723:Fractures, Bone / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D035002:Lower Extremity / Q000473:pathology* / Q000601:surgery; D008297:Male; D055442:Metabolome / Q000235:genetics; D008875:Middle Aged; D016211:Transforming Growth Factor alpha / Q000097:blood; D016212:Transforming Growth Factor beta / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D015415:Biomarkers; D016211:Transforming Growth Factor alpha; D016212:Transforming Growth Factor beta; D014810:Vitamin E; D007334:Insulin-Like Growth Factor I