title: Oral Administration of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) and Honey Improves the Host Body Composition and Modulates Proteolysis Through Reduction of Tumor Progression and Oxidative Stress in Rats.
abstract: Oxidative stress has a dual role in cancer; it is linked with tumorigenic events and host wasting, as well as senescence and apoptosis. Researchers have demonstrated the importance of coadjuvant therapies in cancer treatment, and Aloe vera and honey have immunomodulatory, anticancer, and antioxidant properties. The preventive and therapeutic effects of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) and honey in tumor progression and host wasting were analyzed in Walker 256 carcinoma-bearing rats. The animals were distributed into the following groups: C=control-untreated, W=tumor-untreated, WA=treated after tumor induction, A=control-treated, AW=treated before tumor induction, and AWA=treated before and after tumor induction. Proteolysis and oxidative stress were analyzed in the tumor, liver, muscle, and myocardial tissues. The results suggest that the Aloe vera and honey treatment affect the tumor and host by different mechanisms; the treatment-modulated host wasting and cachexia, whereas it promoted oxidative stress and damage in tumor tissues, particularly in a therapeutic context (WA).
authors: Laboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Institute of Biology, State University of Campinas-UNICAMP , Campinas, São Paulo, Brazil .
authors: Rebeka
authors: R
authors: Tomasin
authors: Laboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Institute of Biology, State University of Campinas-UNICAMP , Campinas, São Paulo, Brazil .
authors: Rafael Siqueira
authors: RS
authors: de Andrade
authors: Laboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Institute of Biology, State University of Campinas-UNICAMP , Campinas, São Paulo, Brazil .
authors: Maria Cristina Cintra
authors: MC
authors: Gomes-Marcondes
mesh_terms: D000284:Administration, Oral; D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D001823:Body Composition / Q000187:drug effects*; D002279:Carcinoma 256, Walker / Q000503:physiopathology / Q000628:therapy*; D006722:Honey; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D059748:Proteolysis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts
keywords: cachexia; cancer; natural compounds