title: Regional Strain Analysis with Multidetector CT in a Swine Cardiomyopathy Model: Relationship to Cardiac MR Tagging and Myocardial Fibrosis.
abstract: OBJECTIVE
  To investigate the use of cine multidetector computed tomography (CT) to detect changes in myocardial function in a swine cardiomyopathy model.
  
  
  METHODS
  All animal protocols were in accordance with the Principles for the Utilization and Care of Vertebrate Animals Used in Testing Research and Training and approved by the University of Missouri Animal Care and Use Committee. Strain analysis of cine multidetector CT images of the left ventricle was optimized and analyzed with feature-tracking software. The standard of reference for strain was harmonic phase analysis of tagged cardiac magnetic resonance (MR) images at 3.0 T. An animal model of cardiomyopathy was imaged with both cardiac MR and 320-section multidetector CT at a temporal resolution of less than 50 msec. Three groups were evaluated: control group (n = 5), aortic-banded myocardial hypertrophy group (n = 5), and aortic-banded and cyclosporine A- treated cardiomyopathy group (n = 5). Histologic samples of the myocardium were obtained for comparison with strain results. Dunnett test was used for comparisons of the concentric remodeling group and eccentric remodeling group against the control group.
  
  
  RESULTS
  Collagen volume fraction ranged from 10.9% to 14.2%; lower collagen fraction values were seen in the control group than in the cardiomyopathy groups (P < .05). Ejection fraction and conventional metrics showed no significant differences between control and cardiomyopathy groups. Radial strain for both cardiac MR and multidetector CT was abnormal in both concentric (cardiac MR 25.1% ± 4.2; multidetector CT 28.4% ± 2.8) and eccentric (cardiac MR 23.2% ± 2.0; multidetector CT 24.4% ± 2.1) remodeling groups relative to control group (cardiac MR 18.9% ± 1.9, multidetector CT 22.0% ± 1.7, P < .05, all comparisons). Strain values for multidetector CT versus cardiac MR showed better agreement in the radial direction than in the circumferential direction (r = 0.55, P = .03 vs r = 0.40, P = .13, respectively).
  
  
  CONCLUSIONS
  Multidetector CT strain analysis has potential to identify regional wall-motion abnormalities in cardiomyopathy that is not otherwise detected using conventional metrics of myocardial function.
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: Michael W
authors: MW
authors: Tee
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: Samuel
authors: S
authors: Won
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: Fabio S
authors: FS
authors: Raman
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: Colin
authors: C
authors: Yi
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: Davis M
authors: DM
authors: Vigneault
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: Cynthia
authors: C
authors: Davies-Venn
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: Songtao
authors: S
authors: Liu
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: Albert C
authors: AC
authors: Lardo
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: João A C
authors: JA
authors: Lima
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: J Alison
authors: JA
authors: Noble
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: Craig A
authors: CA
authors: Emter
authors: From the Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr, Building 10, Rm 1C355, Bethesda, MD 20892-1182 (M.W.T., S.W., F.S.R., C.Y., D.V., C.D.V., S.L., D.A.B.); Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Headington, Oxford, England (M.W.T., D.V., J.A.N.); Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Md (A.L., J.A.C.L., D.A.B.); Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (M.W.T.); Tufts University School of Medicine, Boston, Mass (D.V.); and Department of Biomedical Science, University of Missouri-Columbia, Columbia, Mo (C.E.).
authors: David A
authors: DA
authors: Bluemke
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D057791:Cardiac Imaging Techniques; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000503:physiopathology*; D004195:Disease Models, Animal; D005355:Fibrosis; D008279:Magnetic Resonance Imaging; D008297:Male; D061330:Multidetector Computed Tomography; D009206:Myocardium / Q000473:pathology*; D013552:Swine; D013556:Swine, Miniature