title: Both serum 25-hydroxyvitamin D and calcium levels may increase the risk of incident prostate cancer in Caribbean men of African ancestry.
abstract: Circulating 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with both higher and lower risk of prostate cancer (PCa), whereas elevated levels of circulating calcium has been related to higher risks. However, there are few studies that account for effects of both calcium and 25(OH)D concentrations on incident PCa in a black population. We examined these relationships in a case-control study of men 40-80 years old with newly diagnosed, histologically confirmed PCa in Jamaica, a tropical country. Mean serum calcium concentrations was higher among cases (2.32 ± 0.19 mmol/L) than controls, (2.27 ± 0.30 mmol/L) (P = 0.023) however, there were no differences in 25(OH)D by cancer status (cases, 33.67 ± 12.71 ng/mL; controls (32.25 ± 12.59 ng/mL). Serum calcium was not correlated with 25(OH)D (partial correlation: r, 0.06; P = 0.287). Multivariable-adjusted models showed a positive linear relationship between PCa and serum calcium (OR, 1.12; CI, 1.00-1.25 per 0.1 nmol/L). Serum 25(OH)D concentration also showed a positive association with PCa (OR, 1.23; CI, 1.01-1.49 per 10 ng/mL). The odds of PCa in men with serum 25(OH)D tertile 2 was OR, 2.18; CI, 1.04-4.43 and OR, 2.47 CI, 1.20-4.90 for tertile 3 (P(trend) = 0.013). Dietary intakes of calcium showed no relationship with PCa. Despite the strong relationship between serum calcium and vitamin D the mechanism by which each affects prostate cancer risk in men of African ancestry needs additional investigation.
authors: Department of Community Health & Psychiatry, University of the West Indies, Mona, Kingston, Jamaica.
authors: Maria D
authors: MD
authors: Jackson
authors: Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica.
authors: Marshall K
authors: MK
authors: Tulloch-Reid
authors: Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston, Jamaica.
authors: Carole M
authors: CM
authors: Lindsay
authors: Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston, Jamaica.
authors: Garrett
authors: G
authors: Smith
authors: Department of Pathology, University of the West Indies, Mona Campus, Kingston, Jamaica.
authors: Franklyn I
authors: FI
authors: Bennett
authors: Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston, Jamaica.
authors: Norma
authors: N
authors: McFarlane-Anderson
authors: Department of Surgery, Radiology, Anaesthesia & Intensive Care, University of the West Indies, Mona Campus, Kingston, Jamaica.
authors: William
authors: W
authors: Aiken
authors: Department of Pathology, University of the West Indies, Mona Campus, Kingston, Jamaica.
authors: Kathleen C M
authors: KC
authors: Coard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044383:Black People / Q000208:ethnology; D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage; D016022:Case-Control Studies; D006801:Humans; D007563:Jamaica / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000097:blood* / Q000208:ethnology; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D002136:Calcium, Dietary; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium
keywords: 25 hydroxyvitamin D; African ancestry; serum calcium