title: High Expression of SQSTM1/p62 Protein Is Associated with Poor Prognosis in Epithelial Ovarian Cancer.
abstract: High expression of SQSTM1/p62 (p62) protein, which functions as a hub for various cellular signaling pathways, has been detected in several human cancers. However, the clinicopathological impact of high p62 expression is largely unknown in epithelial ovarian cancer (EOC). Here, the expression level of p62 in primary EOCs (n=266) was assessed by immunohistochemistry, and its clinical significance was analyzed. Univariate and multivariate analyses were used to determine the impact of p62 expression on overall survival. p62 was expressed in the cytoplasm (Cyto) and/or nucleus (Nuc) in primary EOCs, and an expression subtype (Cyto(High)/Nuc(Low)), showing high expression in the cytoplasm but low expression in the nucleus, was significantly correlated with serous carcinoma (P<0.001), advanced stage (P=0.005), presence of residual tumor (P<0.001), and low overall survival rate (P=0.013). Furthermore, in serous carcinomas (n=107), the p62 Cyto(High)/Nuc(Low) subtype was significantly correlated with low overall survival rate (P=0.019) as an independent factor (P=0.044). Thus, our findings suggest that high expression of cytoplasmic p62 may be a novel prognostic biomarker in EOC, particularly in serous carcinoma.
authors: Department of Molecular Cytogenetics, Medical Research Institute and Graduate School of Medical and Dental Science, Tokyo Medical and Dental University , Tokyo, Japan ; Department of Obstetrics and Gynecology, School of Medicine, Keio University , Tokyo, Japan.
authors: Reiko
authors: R
authors: Iwadate
authors: Department of Molecular Cytogenetics, Medical Research Institute and Graduate School of Medical and Dental Science, Tokyo Medical and Dental University , Tokyo, Japan ; Bioresource Research Center, Tokyo Medical and Dental University , Tokyo, Japan.
authors: Jun
authors: J
authors: Inoue
authors: Department of Pathology, National Defense Medical College , Saitama, Japan.
authors: Hitoshi
authors: H
authors: Tsuda
authors: Department of Obstetrics and Gynecology, National Defense Medical College.
authors: Masashi
authors: M
authors: Takano
authors: Department of Obstetrics and Gynecology, National Defense Medical College.
authors: Kenichi
authors: K
authors: Furuya
authors: Department of Obstetrics and Gynecology, School of Medicine, Keio University , Tokyo, Japan.
authors: Akira
authors: A
authors: Hirasawa
authors: Department of Obstetrics and Gynecology, School of Medicine, Keio University , Tokyo, Japan.
authors: Daisuke
authors: D
authors: Aoki
authors: Department of Molecular Cytogenetics, Medical Research Institute and Graduate School of Medical and Dental Science, Tokyo Medical and Dental University , Tokyo, Japan ; Bioresource Research Center, Tokyo Medical and Dental University , Tokyo, Japan ; Department of Genome Medicine, Hard Tissue Genome Research Center, Tokyo Medical and Dental University , Tokyo, Japan.
authors: Johji
authors: J
authors: Inazawa
keywords: epithelial ovarian cancer; immunohistochemistry; p62; prognosis; serous carcinoma