title: Psoralen derivatives as inhibitors of NF-κB interaction: the critical role of the furan ring.
abstract: Simplified analogues of previously reported NF-κB interaction inhibitors, lacking the furan moiety, were synthesized and evaluated by performing experiments based on electrophoretic mobility shift assay (EMSA). The synthetic modifications led to simpler coumarin derivatives with lower activity allowing to better understand the minimal structural requirement for the binding to NF-κB.
authors: Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131, Padova, Italy.
authors: Giovanni
authors: G
authors: Marzaro
authors: Ilaria
authors: I
authors: Lampronti
authors: Monica
authors: M
authors: Borgatti
authors: Paolo
authors: P
authors: Manzini
authors: Roberto
authors: R
authors: Gambari
authors: Adriana
authors: A
authors: Chilin
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D005363:Ficusin / Q000737:chemistry* / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D016328:NF-kappa B / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D011487:Protein Conformation; D021281:Quantitative Structure-Activity Relationship
chemical_list: D005663:Furans; D016328:NF-kappa B; D004247:DNA; D005363:Ficusin; C039281:furan