title: Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease.
abstract: Deep brain stimulation (DBS) is increasingly applied for the treatment of brain disorders, but its mechanism of action remains unknown. Here we evaluate the effect of basal ganglia DBS on cortical function using invasive cortical recordings in Parkinson's disease (PD) patients undergoing DBS implantation surgery. In the primary motor cortex of PD patients, neuronal population spiking is excessively synchronized to the phase of network oscillations. This manifests in brain surface recordings as exaggerated coupling between the phase of the beta rhythm and the amplitude of broadband activity. We show that acute therapeutic DBS reversibly reduces phase-amplitude interactions over a similar time course as that of the reduction in parkinsonian motor signs. We propose that DBS of the basal ganglia improves cortical function by alleviating excessive beta phase locking of motor cortex neurons.
authors: Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
authors: Coralie
authors: C
authors: de Hemptinne
authors: Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
authors: Nicole C
authors: NC
authors: Swann
authors: Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
authors: Jill L
authors: JL
authors: Ostrem
authors: Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
authors: Elena S
authors: ES
authors: Ryapolova-Webb
authors: Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
authors: Marta
authors: M
authors: San Luciano
authors: Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
authors: Nicholas B
authors: NB
authors: Galifianakis
authors: 1] Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA. [2] Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California, USA.
authors: Philip A
authors: PA
authors: Starr
mesh_terms: D061725:Accelerometry; D000368:Aged; D001132:Arm / Q000503:physiopathology; D001479:Basal Ganglia / Q000503:physiopathology; D001611:Beta Rhythm / Q000502:physiology*; D046690:Deep Brain Stimulation; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D009068:Movement; D009127:Muscle Rigidity / Q000503:physiopathology; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D014202:Tremor / Q000503:physiopathology