title: Levels in plasma of the serine proteases and associated proteins of the lectin pathway are altered in patients with systemic lupus erythematosus.
abstract: OBJECTIVE
  To examine whether proteins of the lectin pathway of the complement system are involved in systemic lupus erythematosus (SLE) pathogenesis.
  
  
  METHODS
  Using time-resolved immunofluorometric assays, plasma levels of mannan-binding lectin (MBL)-associated serine proteases 1 (MASP-1), MASP-2, MASP-3, MBL-associated protein of 19 kDa (MAp19), and MAp44 were determined in 58 patients with SLE and 65 healthy controls (HC).
  
  
  RESULTS
  Plasma concentrations in patients with SLE were higher than HC regarding MASP-1, MASP-3, and MAp44 (p < 0.0001, 0.0003, and 0.0013). Complement factor 3 correlated negatively and anti-dsDNA positively with levels of MAp19 (p = 0.0035, p = 0.0133).
  
  
  CONCLUSIONS
  In SLE, plasma levels of MASP and MAp are altered and associated with SLE characteristics, supporting a role in SLE pathogenesis.
authors: From the Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, and Department of Biomedicine, Aarhus University, Aarhus, Denmark.A. Troldborg, MD, PhD candidate, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University; S. Thiel, Professor; M.J. Laska, PhD, Assistant Professor, Department of Biomedicine, Aarhus University; B. Deleuran, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Biomedicine, Aarhus University; J.C. Jensenius, DrMed, DrPhil, Professor, Department of Biomedicine, Aarhus University; K. Stengaard-Pedersen, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University. annetrol@rm.dk.
authors: Anne
authors: A
authors: Troldborg
authors: From the Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, and Department of Biomedicine, Aarhus University, Aarhus, Denmark.A. Troldborg, MD, PhD candidate, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University; S. Thiel, Professor; M.J. Laska, PhD, Assistant Professor, Department of Biomedicine, Aarhus University; B. Deleuran, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Biomedicine, Aarhus University; J.C. Jensenius, DrMed, DrPhil, Professor, Department of Biomedicine, Aarhus University; K. Stengaard-Pedersen, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University.
authors: Steffen
authors: S
authors: Thiel
authors: From the Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, and Department of Biomedicine, Aarhus University, Aarhus, Denmark.A. Troldborg, MD, PhD candidate, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University; S. Thiel, Professor; M.J. Laska, PhD, Assistant Professor, Department of Biomedicine, Aarhus University; B. Deleuran, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Biomedicine, Aarhus University; J.C. Jensenius, DrMed, DrPhil, Professor, Department of Biomedicine, Aarhus University; K. Stengaard-Pedersen, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University.
authors: Magdalena Janina
authors: MJ
authors: Laska
authors: From the Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, and Department of Biomedicine, Aarhus University, Aarhus, Denmark.A. Troldborg, MD, PhD candidate, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University; S. Thiel, Professor; M.J. Laska, PhD, Assistant Professor, Department of Biomedicine, Aarhus University; B. Deleuran, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Biomedicine, Aarhus University; J.C. Jensenius, DrMed, DrPhil, Professor, Department of Biomedicine, Aarhus University; K. Stengaard-Pedersen, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University.
authors: Bent
authors: B
authors: Deleuran
authors: From the Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, and Department of Biomedicine, Aarhus University, Aarhus, Denmark.A. Troldborg, MD, PhD candidate, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University; S. Thiel, Professor; M.J. Laska, PhD, Assistant Professor, Department of Biomedicine, Aarhus University; B. Deleuran, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Biomedicine, Aarhus University; J.C. Jensenius, DrMed, DrPhil, Professor, Department of Biomedicine, Aarhus University; K. Stengaard-Pedersen, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University.
authors: Jens Christian
authors: JC
authors: Jensenius
authors: From the Department of Rheumatology, Aarhus University Hospital; Department of Clinical Medicine, and Department of Biomedicine, Aarhus University, Aarhus, Denmark.A. Troldborg, MD, PhD candidate, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University; S. Thiel, Professor; M.J. Laska, PhD, Assistant Professor, Department of Biomedicine, Aarhus University; B. Deleuran, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Biomedicine, Aarhus University; J.C. Jensenius, DrMed, DrPhil, Professor, Department of Biomedicine, Aarhus University; K. Stengaard-Pedersen, DrMed, Professor, Department of Rheumatology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University.
authors: Kristian
authors: K
authors: Stengaard-Pedersen
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003165:Complement System Proteins / Q000378:metabolism; D003430:Cross-Sectional Studies; D003718:Denmark; D018450:Disease Progression; D005260:Female; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D016015:Logistic Models; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology* / Q000503:physiopathology*; D037601:Mannose-Binding Lectin / Q000235:genetics / Q000378:metabolism*; D050606:Mannose-Binding Protein-Associated Serine Proteases / Q000378:metabolism*; D008875:Middle Aged; D012680:Sensitivity and Specificity; D057057:Serine Proteases / Q000097:blood / Q000378:metabolism; D012720:Severity of Illness Index; D015398:Signal Transduction; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D037601:Mannose-Binding Lectin; D003165:Complement System Proteins; D057057:Serine Proteases; D050606:Mannose-Binding Protein-Associated Serine Proteases
keywords: COMPLEMENT SYSTEM; INNATE IMMUNITY; LECTIN PATHWAY; SYSTEMIC LUPUS ERYTHEMATOSUS