title: SnapShot: Origins of DNA replication.
abstract: The fundamental unit of DNA replication, the replicon, is governed by a cis-acting replicator sequence and a trans-activating initiator factor. Despite the increased size and complexity of eukaryotic genomes, eukaryotic DNA replication continues to be guided by the fundamental principles and concepts established in the replicon model.
authors: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
authors: Rachel L
authors: RL
authors: Creager
authors: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
authors: Yulong
authors: Y
authors: Li
authors: Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA.
authors: David M
authors: DM
authors: MacAlpine
mesh_terms: D000818:Animals; D001419:Bacteria / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D044127:Epigenesis, Genetic; D056890:Eukaryota / Q000378:metabolism*; D042421:Histone Code; D006801:Humans; D018741:Replication Origin
chemical_list: D004247:DNA