title: Effective targeting of primitive AML CD34+ cells by the second-generation proteasome inhibitor carfilzomib.
authors: Department of Haematology, Cancer Research Centre Groningen (CRCG), University Medical Centre Groningen (UMCG), University of Groningen, Groningen, The Netherlands.
authors: Lieke H
authors: LH
authors: van der Helm
authors: Department of Haematology, Cancer Research Centre Groningen (CRCG), University Medical Centre Groningen (UMCG), University of Groningen, Groningen, The Netherlands.
authors: Matthieu C J
authors: MC
authors: Bosman
authors: Department of Haematology, Cancer Research Centre Groningen (CRCG), University Medical Centre Groningen (UMCG), University of Groningen, Groningen, The Netherlands.
authors: Jan J
authors: JJ
authors: Schuringa
authors: Department of Haematology, Cancer Research Centre Groningen (CRCG), University Medical Centre Groningen (UMCG), University of Groningen, Groningen, The Netherlands. e.vellenga@umcg.nl.
authors: Edo
authors: E
authors: Vellenga
mesh_terms: D000069286:Bortezomib / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D017930:Genes, Reporter; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D018922:HL-60 Cells; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D009363:Neoplasm Proteins / Q000378:metabolism; D009842:Oligopeptides / Q000494:pharmacology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D061988:Proteasome Inhibitors / Q000494:pharmacology*; D059748:Proteolysis; D014407:Tumor Cells, Cultured; D014410:Tumor Stem Cell Assay
chemical_list: D009363:Neoplasm Proteins; C554738:ONX 0912; D009842:Oligopeptides; D061988:Proteasome Inhibitors; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; D000069286:Bortezomib; C524865:carfilzomib; D046988:Proteasome Endopeptidase Complex
keywords: acute leukaemia; bortezomib; carfilzomib; oprozomib; stem cells