title: [Association of VKORC1 gene -1639G/A polymorphism with atrial fibrillation in ethnic Uygurs and Hans from Xinjiang].
abstract: OBJECTIVE
  To assess the association of VKORC1 gene -1639G/A polymorphism with atrial fibrillation (AF) in ethnic Uygurs and Hans from Xinjiang.
  
  
  METHODS
  The above polymorphism was detected among 100 Uygur and 102 Han AF patients and 103 Uygur and 111 Han subjects that have no AF with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
  
  
  RESULTS
  A statistically significant difference was detected between the patient and control groups of Uygur origin in terms of genotypic and allelic frequencies (P<0.05). Logistic regression analysis also indicated the -1639G/A polymorphism as an independent risk factor for AF in Uygur population (OR=2.085, 95% CI: 1.067-4.072, P=0.031). No similar statistical difference was found between the patient and control groups of Han origin (P>0.05).
  
  
  CONCLUSIONS
  The -1639G/A polymorphism of VKORC1 gene is associated with AF in the Uygur population but not in Hans.
authors: Cardiac Pacing and Electrophysiological Division, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China. tangbaopeng@hotmail.com.
authors: Peisong
authors: P
authors: Wu
authors: Siqi
authors: S
authors: Meng
authors: Xianhui
authors: X
authors: Zhou
authors: Guojun
authors: G
authors: Xu
authors: Jinxin
authors: J
authors: Li
authors: Yu
authors: Y
authors: Zhang
authors: Ling
authors: L
authors: Sun
authors: Qiang
authors: Q
authors: Xing
authors: Shuai
authors: S
authors: Sun
authors: Hongli
authors: H
authors: Wang
authors: Qina
authors: Q
authors: Zhou
authors: Baopeng
authors: B
authors: Tang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D001281:Atrial Fibrillation / Q000208:ethnology* / Q000235:genetics*; D001483:Base Sequence; D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D064417:Vitamin K Epoxide Reductases / Q000235:genetics*
chemical_list: C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases