title: Comparison of the pathogenesis of single or dual infections with type 1 and type 2 porcine reproductive and respiratory syndrome virus.
abstract: The aim of this study was to compare the pathogenicity of single or dual infections with type 1 and type 2 porcine reproductive and respiratory syndrome virus (PRRSV) in pigs. Pigs were inoculated intranasally with type 1 or type 2 PRRSV or both viruses together. Pigs infected with type 1 and type 2 PRRSV together had significantly (P <0.05) fewer genomic copies of type 1 PRRSV than did pigs infected with type 1 PRRSV alone. Pigs infected with type 2 PRRSV alone or type 1 and type 2 PRRSV together had significantly (P <0.05) higher gross and microscopical lung lesion scores than did pigs infected with type 1 PRRSV alone. Pigs infected with type 2 PRRSV alone or type 1 and type 2 PRRSV together had significantly (P <0.05) higher scores for PRRSV-positive cells in the lung than did pigs infected with type 1 PRRSV alone. Pigs infected with type 1 PRRSV alone had significantly (P <0.05) higher scores for type 1 PRRSV-positive cells in the lung than did pigs infected with both types of PRRSV together. Pigs infected with both types of PRRSV together developed similar clinical disease and lesions as pigs infected with type 2 PRRSV alone. Significant differences in virulence were not observed between pigs infected with type 2 PRRSV alone and pigs infected with both types of PRRSV together in terms of viraemia, lung lesion score and virus distribution within lung lesions.
authors: College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
authors: K
authors: K
authors: Choi
authors: College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea; General Animal Health Division, Ministry of Agriculture, Food and Rural Affairs, 94 Dasom 2-ro, Government Complex-Sejong, Sejong-si, Republic of Korea.
authors: J
authors: J
authors: Lee
authors: College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
authors: C
authors: C
authors: Park
authors: College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
authors: J
authors: J
authors: Jeong
authors: College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea. Electronic address: swine@snu.ac.kr.
authors: C
authors: C
authors: Chae
mesh_terms: D000818:Animals; D008168:Lung / Q000473:pathology* / Q000821:virology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000473:pathology* / Q000821:virology; D019316:Porcine respiratory and reproductive syndrome virus; D013552:Swine
keywords: co-infection; pig; porcine reproductive and respiratory syndrome virus