title: Engineering clinically relevant volumes of vascularized bone.
abstract: Vascularization remains one of the most important challenges that must be overcome for tissue engineering to be consistently implemented for reconstruction of large volume bone defects. An extensive vascular network is needed for transport of nutrients, waste and progenitor cells required for remodelling and repair. A variety of tissue engineering strategies have been investigated in an attempt to vascularize tissues, including those applying cells, soluble factor delivery strategies, novel design and optimization of bio-active materials, vascular assembly pre-implantation and surgical techniques. However, many of these strategies face substantial barriers that must be overcome prior to their ultimate translation into clinical application. In this review recent progress in engineering vascularized bone will be presented with an emphasis on clinical feasibility.
authors: Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA; Research Service, Edward Hines Jr. V.A. Hospital, Hines, IL, USA.
authors: Brianna M
authors: BM
authors: Roux
authors: Ming-Huei
authors: MH
authors: Cheng
authors: Eric M
authors: EM
authors: Brey
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods; D001842:Bone and Bones / Q000098:blood supply* / Q000502:physiology*; D006801:Humans; D018919:Neovascularization, Physiologic; D010012:Osteogenesis; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials
keywords: bone tissue engineering; clinical applications; vascularization