title: EGFR-Mutated Breast Metastasis of Lung Adenocarcinoma: A Case Report.
abstract: Breast metastasis from other primary carcinoma is very rare and could be difficult to identify despite immunohistochemistry analysis. Breast metastasis from lung adenocarcinoma can mimic triple-negative breast cancer. Given the prognosis and therapeutic challenges, a correct diagnosis appears essential, and molecular biomarkers could be useful. We report the case of a 52-year-old woman with a breast mass initially diagnosed as primary breast cancer and secondarily attached to breast metastasis from an EGFR-mutated lung adenocarcinoma. The same activating EGFR mutations were identified in both the primary lung carcinoma and the breast metastasis.
authors: Département de Cancérologie Générale, France.
authors: Eric
authors: E
authors: Dansin
authors: Département de Cancérologie Générale, France.
authors: Aurélien
authors: A
authors: Carnot
authors: Département de Sénologie, France.
authors: Véronique
authors: V
authors: Servent
authors: Unité de Pathologie Morphologique et Moléculaire, France.
authors: Dorothée
authors: D
authors: Daussay
authors: Unité de Pathologie Morphologique et Moléculaire, France.
authors: Yves-Marie
authors: YM
authors: Robin
authors: Service de Chirurgie Thoracique, Hôpital Calmette, France.
authors: Ecaterina
authors: E
authors: Surmei-Pintilie
authors: Département de Cancérologie Générale, France ; Département de Sénologie, France.
authors: Géraldine
authors: G
authors: Lauridant
authors: Plateforme Régionale CHRU-COL de Génétique Moléculaire des Cancers, France.
authors: Clothilde
authors: C
authors: Descarpentries
authors: Unité d'Oncologie Moléculaire Humaine, CLCC Oscar Lambret, France ; Plateforme Régionale CHRU-COL de Génétique Moléculaire des Cancers, France.
authors: Françoise
authors: F
authors: Révillion
authors: Centre de Pathologie, CHRU Lille, Lille, France.
authors: Claire
authors: C
authors: Delattre
keywords: Breast metastasis; EGFR mutation; EGFR tyrosine kinase inhibitors; Lung adenocarcinoma; Triple-negative breast cancer