title: Metallothionein immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour.
abstract: BACKGROUND
  To compare the metallothionein (MT) immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour (KOT), to correlate MT with cellular proliferation, and to evaluate the influence of inflammation in MT.
  
  
  METHODS
  Fourteen cases of KOT were submitted to immunohistochemistry for MT and Ki-67 analysis. The lesions were grouped according to their grade of inflammation, and statistical analysis was performed.
  
  
  RESULTS
  MT was higher in non-syndromic KOT than in syndromic KOT (p<0.05). No statistical difference in Ki-67 could be identified; however, an inverse correlation was observed between MT and Ki-67 in both lesions. When analysing inflammation, non-syndromic KOT showed no differences in either MT or Ki-67.
  
  
  CONCLUSIONS
  The MT immunophenotype of syndromic KOT was different from non-syndromic KOT. MT might not be involved in the proliferation control of both KOT. MT and Ki-67 immunoexpressions proved to be unaffected by inflammation in non-syndromic KOT.
authors: Universidade Federal de Minas Gerais, Faculdade de Odontologia, Av. Antônio Carlos, 6627 sala 3201, Pampulha, Belo Horizonte, MG, Brasil, pat_caldeira@yahoo.com.br.
authors: Aline-Cristina-Batista-Rodrigues
authors: AC
authors: Johann
authors: Patrícia-Carlos
authors: PC
authors: Caldeira
authors: Marcelo-Vidigal
authors: MV
authors: Caliari
authors: Ricardo-Santiago
authors: RS
authors: Gomez
authors: Maria-Cássia-Ferreira
authors: MC
authors: Aguiar
authors: Ricardo-Alves
authors: RA
authors: Mesquita
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis / Q000276:immunology; D008668:Metallothionein / Q000096:biosynthesis / Q000276:immunology*; D009807:Odontogenic Cysts / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D013577:Syndrome
chemical_list: D019394:Ki-67 Antigen; D008668:Metallothionein