title: Prognostic Value of C-met Expression in Cholangiocarcinoma.
abstract: OBJECTIVE
  To explore the relationship of clinicopathological features and the proteins of C-met expression in the prognosis of cholangiocarcinoma.
  
  
  METHODS
  Clinical data and the completed follow-up information of patients with cholangiocarcinoma who underwent cholangiocarcinoma operation from January 2004 to December 2010 were analyzed retrospectively. The relationship of clinicopathological features and C-met in the prognosis of the patients was analyzed.
  
  
  RESULTS
  Patients with high expression of C-met had significantly shorter overall survival than those with low expression of C-met, the difference being statistically significant (P = .003). Patients with high C-met expression had significantly shorter disease-free survival time than those with low expression of C-met, the difference being statistically significant (P = .009). By COX multivariate analysis, high C-met expression in tumor tissues was an independent risk factor in predicting overall survival and disease-free survival for patients with cholangiocarcinoma (P = .038, .048, relative risk = 1.390, 1.427).
  
  
  CONCLUSIONS
  Patients with high C-met expression in cancer tissues had shorter disease-free survival and overall survival. High expression of C-met is an independent risk factor for overall survival and disease-free survival.
authors: Department of Oncology, Air Force General Hospital of PLA, Beijing, China maozhiyuan666@163.com.
authors: Zhi-Yuan
authors: ZY
authors: Mao
authors: Department of Oncology, Air Force General Hospital of PLA, Beijing, China.
authors: Guang-Qing
authors: GQ
authors: Zhu
authors: Department of Pathology, Air Force General Hospital of PLA, Beijing, China.
authors: Li
authors: L
authors: Ren
authors: Department of Oncology, Chinese PLA General Hospital, Beijing, China.
authors: Xiao-Chuan
authors: XC
authors: Guo
authors: Department of Oncology, Chinese PLA General Hospital, Beijing, China.
authors: Dan
authors: D
authors: Su
authors: Department of Oncology, Chinese PLA General Hospital, Beijing, China.
authors: Li
authors: L
authors: Bai
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000201:enzymology* / Q000401:mortality; D001653:Bile Ducts, Intrahepatic / Q000201:enzymology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D018281:Cholangiocarcinoma / Q000201:enzymology* / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met
keywords: C-met; cholangiocarcinoma; prognosis; surgery; tumor microenvironment