title: Pathologic leadpoint is uncommon in ileo-colic intussusception regardless of age.
abstract: OBJECTIVE
  Historically, the rate of pathologic leadpoints in older children with intussusception is quoted as 20%-25%. Our anecdotal experience suggested a lower rate. We therefore compiled a case series to examine the actual incidence of pathologic leadpoint, and treatment success, by age.
  
  
  METHODS
  A retrospective review was performed of all patients admitted with intussusception between 1998 and 2012 and tested for differences in anatomic location, presence of pathologic leadpoint, and need for operative intervention, on the basis of age.
  
  
  RESULTS
  In total, 154 cases of intussusception were diagnosed in 141 patients (136 ileo-colic), 38 of which were in children older than 3 (29 ileo-colic). Considering all anatomic locations, older children were more likely to have a pathologic leadpoint (p-value 0.01); however subgroup analysis of ileo-colic intussusception demonstrated no difference (p-value 0.38). Additionally, there was no difference in the success of pneumatic or barium enema reduction on the basis of age (p-value 0.56).
  
  
  CONCLUSIONS
  Despite historical reports of increased pathologic leadpoints in ileo-colic intussusception in older children, in this series the majority were idiopathic. Non-operative management was successful approximately 75% of the time, irrespective of age. In older age groups, there was an increased frequency of pathologic leadpoints in small bowel-small bowel intussusception.
authors: Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. Electronic address: jill.rubinstein@yale.edu.
authors: Jill C
authors: JC
authors: Rubinstein
authors: Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
authors: Lucy
authors: L
authors: Liu
authors: Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
authors: Michael G
authors: MG
authors: Caty
authors: Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. Electronic address: emily.christison-lagay@yale.edu.
authors: Emily R
authors: ER
authors: Christison-Lagay
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000473:pathology* / Q000628:therapy; D007223:Infant; D007443:Intussusception / Q000473:pathology* / Q000628:therapy; D008297:Male; D012189:Retrospective Studies
keywords: Intussusception; Pathologic leadpoint