title: Transition-metal-free trifluoromethylthiolation of N-heteroarenes.
abstract: A general and efficient methodology for the direct transition metal free trifluoromethylthiolation of a broad range of biologically relevant N-heteroarenes is reported employing abundant sodium chloride as the catalyst. This method is operationally simple, exhibits high functional group tolerance, and does not require protecting groups.
authors: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster (Germany).
authors: Roman
authors: R
authors: Honeker
authors: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster (Germany).
authors: Johannes B
authors: JB
authors: Ernst
authors: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster (Germany). glorius@uni-muenster.de.
authors: Frank
authors: F
authors: Glorius
mesh_terms: D054879:Halogenation; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D008745:Methylation; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D008670:Metals; D013438:Sulfhydryl Compounds; D028561:Transition Elements
keywords: N-heterocycles; electrophilic substitution; sodium chloride; synthetic methods; trifluoromethylthiolation