title: A monocrystal graphene domain biosensor array with differential output for real-time monitoring of glucose and normal saline.
abstract: A biosensor array with differential output based on a monocrystal graphene domain is proposed to realize high resolution measurements. The differential output structure can eliminate the noise that comes from graphene crystal orientation and grain boundary, as well as the fluctuation that comes from the contact resistance and experiment process, so as to improve resolution in the lower concentration. We have fabricated a high quality monocrystal graphene domain that has millimeter size by the chemical vapor deposition method. Two identical graphene ribbons that are cut from the same domain are used as field effect transistor source-to-drain channels for the reference and the test of differential output, respectively. The experimental results show that the source-to-drain current has a fast response shorter than 0.5 second in glucose, normal saline and pH buffer solutions of different concentrations. Sensitivity increases exponentially with the increase of concentration of the tested liquid and the high resolution range is 0.01-2 wt% in glucose and 0.0009-0.018 wt% in saline, and the highest resolutions of glucose and saline are 0.01 wt% and 0.0009 wt%, respectively. We have fabricated a 1 × 4 array structure with differential outputs that pave the way for rapidly detecting ultra-low concentration of analytes.
authors: Department of Microelectronics, School of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, 710049, China. lx@mail.xjtu.edu.cn.
authors: Junjie
authors: J
authors: Shi
authors: Xin
authors: X
authors: Li
authors: Qian
authors: Q
authors: Chen
authors: Kun
authors: K
authors: Gao
authors: Hui
authors: H
authors: Song
authors: Shixi
authors: S
authors: Guo
authors: Quanfu
authors: Q
authors: Li
authors: Ming
authors: M
authors: Fang
authors: Weihua
authors: W
authors: Liu
authors: Hongzhong
authors: H
authors: Liu
authors: Xiaoli
authors: X
authors: Wang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D012965:Sodium Chloride / Q000032:analysis* / Q000737:chemistry
chemical_list: D012965:Sodium Chloride; D006108:Graphite; D005947:Glucose