title: Expressions and clinical significance of serum bone Gla-protein, bone alkaline phosphatase and C-terminal telopeptide of type I collagen in bone metabolism of patients with osteoporosis.
abstract: OBJECTIVE
  This study aimed to evaluate the expressions and clinical significance of bone Gla-protein (BGP), bone alkaline phosphatase (B-ALP) and C-terminal telopeptide of type I collagen (CTX) in patients with osteoporosis (OP), and to provide evidence for developing individualized treatment plans.
  
  
  METHODS
  Seventy-two OP patients in our hospital were selected as an OP group, and another 72 healthy subjects were used as a control group. Their BGP, B-ALP and CTX levels as well as bone mineral density (BMD) values were measured. The correlations between BGP, B-ALP and CTX levels and BMD values were determined.
  
  
  RESULTS
  The BGP level of the OP group [(5.61±5.52) ng/ml] was significantly higher than that of the control group (P<0.05), but the levels of B-ALP and CTX did not differ significantly (P>0.05). The BMD values of femoral neck and Ward's triangle in the OP group were negatively correlated with the B-ALP levels (P<0.05). For women OP patients, the BMD values of femoral neck and Ward's triangle were also negatively correlated with the B-ALP levels (P<0.05). The BMD of femoral neck in the control group was negatively correlated with the CTX level (P<0.05).
  
  
  CONCLUSIONS
  Determining BGP, B-ALP and CTX levels can evaluate the bone metabolism degree, which provides evidence for clinical typing of OP and developing treatment strategies.
authors: Dongfeng Zhao, Department of Orthopedics, The 210th Hospital of People's Liberation Army, Dalian 116021, PR China.
authors: Dongfeng
authors: D
authors: Zhao
authors: Junsheng Wang, Department of Orthopedics, The 210th Hospital of People's Liberation Army, Dalian 116021, PR China.
authors: Junsheng
authors: J
authors: Wang
authors: Yining Liu, Department of Orthopedics, The 210th Hospital of People's Liberation Army, Dalian 116021, PR China.
authors: Yining
authors: Y
authors: Liu
authors: Xinwei Liu, Department of Orthopedics, The 210th Hospital of People's Liberation Army, Dalian 116021, PR China.
authors: Xinwei
authors: X
authors: Liu
keywords: Bone Gla-protein; Bone alkaline phosphatase; C-terminal telopeptide of type I collagen; Osteoporosis