title: Environmental and metabolic sensors that control T cell biology.
abstract: The T lymphocyte response to pathogens is shaped by the microenvironment. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin complex 1. Other environmental sensors are transcription factors such as hypoxia-inducible factor-1 and the aryl hydrocarbon receptor. The present review explores the molecular basis for the impact of environmental signals on the differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune stimuli can coordinate the T cell response to environmental cues.
authors: Division of Cell Signalling and Immunology, University of Dundee , Dundee , UK.
authors: George
authors: G
authors: Ramsay
authors: Division of Cell Signalling and Immunology, University of Dundee , Dundee , UK.
authors: Doreen
authors: D
authors: Cantrell
keywords: T cell metabolism; amino acid uptake; aryl hydrocarbon; glucose uptake; hypoxia; leucine and mTOR; microbiome