title: Clinical perspectives: practical insights from clinical experience with cabazitaxel in Australia.
abstract: Prostate cancer, and in particular the management options for patients with metastatic castration-resistant prostate cancer (mCRPC), remains an important health issue. The approval of cabazitaxel provides a new treatment option for patients who have progressed despite docetaxel therapy. Clinical use of cabazitaxel in mCRPC is based on the results of the TROPIC study, which demonstrated an approximately 30% reduction in the risk of death compared with mitoxantrone. In this paper, we draw on accumulating clinical experience with cabazitaxel in Australia to discuss important questions such as how to select the right patient for treatment and how to proactively prevent and manage toxicities associated with this therapy. Recognizing the need for a multidisciplinary approach to patient care, opinion and insight has been sought from medical oncologists, nurses and pharmacists. While lack of trial data means that a number of questions remain unanswered, local clinical experience has helped to guide treatment decisions and refine management protocols. Appropriate patient selection, careful ongoing monitoring and proactive management of adverse events will ensure optimal treatment of patients. Nurses in particular play an important role in educating patients and identifying patients at increased risk of developing adverse events with cabazitaxel. The oncology team must work together to educate patients; taking a proactive approach to issues such as adverse events will help maximize the clinical outcome of cabazitaxel treatment and impact positively on the patient's quality of life.
authors: Medical Oncology, Box Hill Hospital, Box Hill, Australia.|Faculty of Medicine, Monash University, Melbourne, Victoria, Australia.
authors: Phillip
authors: P
authors: Parente
authors: Clinical Research, Medical Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
authors: Howard
authors: H
authors: Gurney
authors: Clinical Oncology, St John of God Private Hospital, Bendat Family Comprehensive Cancer Centre, Subiaco, Western Australia, Australia.
authors: Siobhan
authors: S
authors: Ng
authors: Clinical Oncology, St John of God Private Hospital, Bendat Family Comprehensive Cancer Centre, Subiaco, Western Australia, Australia.
authors: Martina
authors: M
authors: Bahre
mesh_terms: D001315:Australia; D006801:Humans; D008297:Male; D064129:Prostatic Neoplasms, Castration-Resistant / Q000188:drug therapy*; D011788:Quality of Life; D043823:Taxoids / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D043823:Taxoids; C552428:cabazitaxel
keywords: adverse drug event; cancer chemotherapy drug; castration-resistant prostate cancer; drug toxicity; patient safety