title: Decreased Perifoveal Sensitivity Detected by Microperimetry in Patients Using Hydroxychloroquine and without Visual Field and Fundoscopic Anomalies.
abstract: Purpose. To evaluate the usefulness of microperimetry in the early detection of the ocular anomalies associated with the use of hydroxychloroquine. Methods. Prospective comparative case series study comprising 14 healthy eyes of 7 patients (group A) and 14 eyes of 7 patients under treatment with hydroxychloroquine for the treatment of rheumatologic diseases and without fundoscopic or perimetric anomalies (group B). A comprehensive ophthalmological examination including microperimetry (MP) and spectral-domain optical coherence tomography was performed in both groups. Results. No significant differences were found in mean MP foveal sensitivity between groups (P = 0.18). However, mean MP overall sensitivity was significantly higher in group A (29.05 ± 0.57 dB versus group B, 26.05 ± 2.75 dB; P < 0.001). Significantly higher sensitivity values were obtained in group A in comparison to group B for the three eccentric loci evaluated (P < 0.001). Conclusion. Microperimetry seems to be a useful tool for the early detection of retinal damage in patients treated with hydroxychloroquine.
authors: Clínica Optométrica, Fundació Lluis Alcanyis, Universitat de Valencia, Calle de la Guardia Civil 22, 46020 Valencia, Spain.
authors: A
authors: A
authors: Molina-Martín
authors: Oftalmar, Hospital Internacional Medimar, Edificio de Especialidades, 03016 Alicante, Spain ; Departamento de Óptica, Anatomía y Farmacología, Universidad de Alicante, Carretera de San Vicente del Raspeig s/n, 03690 Alicante, Spain.
authors: D P
authors: DP
authors: Piñero
authors: Oftalmar, Hospital Internacional Medimar, Edificio de Especialidades, 03016 Alicante, Spain.
authors: R J
authors: RJ
authors: Pérez-Cambrodí