title: Failure of azithromycin 2.0 g in the treatment of gonococcal urethritis caused by high-level resistance in California.
abstract: We report a treatment failure to azithromycin 2.0 g caused by a urethral Neisseria gonorrhoeae isolate with high-level azithromycin resistance in California. This report describes the epidemiological case investigation and phenotypic and genetic characterization of the treatment failure isolate.
authors: From the *San Francisco Public Health Laboratory, San Francisco Department of Public Health, San Francisco, CA; †Neisseria Reference Laboratory, Department of Global Health and Center for AIDS and STD, University of Washington, Seattle, WA; ‡Public Health Laboratory, San Luis Obispo Department of Public Health, San Luis Obispo, CA; and §Sexually Transmitted Disease (STD) Control Branch, Division of Communicable Disease Control (DCDC), Center for Infectious Diseases (CID), California Department of Public Health (CDPH), Richmond, CA.
authors: Severin O
authors: SO
authors: Gose
authors: Olusegun O
authors: OO
authors: Soge
authors: James L
authors: JL
authors: Beebe
authors: Duylinh
authors: D
authors: Nguyen
authors: Juliet E
authors: JE
authors: Stoltey
authors: Heidi M
authors: HM
authors: Bauer
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017963:Azithromycin / Q000494:pharmacology*; D002140:California / Q000453:epidemiology; D002443:Ceftriaxone / Q000008:administration & dosage*; D016358:Contact Tracing; D024881:Drug Resistance, Bacterial; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy* / Q000235:genetics / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000235:genetics; D011159:Population Surveillance; D017211:Treatment Failure; D014481:United States / Q000453:epidemiology; D014526:Urethritis / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D017963:Azithromycin