title: Association of monocyte chemoattractant protein-1 (MCP-1)-2518A>G polymorphism with susceptibility to coronary artery disease: a meta-analysis.
abstract: We attempted to systematically elucidate the association between monocyte chemoattractant protein-1 (MCP-1) -2518A>G polymorphism and risk of coronary artery disease (CAD). Eligible studies were identified through PubMed, EBSCO, and Web of Science Databases. The magnitude of MCP-1 polymorphism effect and its possible mode of action on CAD were estimated. The odds ratio (OR) with 95% confidence intervals (CI) were pooled in a specific genetic model to assess the association. A total of 21 studies were involved. There was significant gene effect on CAD risk in the overall population (likelihood ratio test: p < 0.0001). Patients with GG and AG genotypes had 1.435 (95% CI: 1.183-1.740) and 1.087 (95% CI: 1.008-1.172) times higher risk of CAD than those with AA genotype. These gene effects suggested a recessive model to be appropriate. The pooled OR was 1.362 (95% CI: 1.137-1.631; puncorrected = 0.001, pFDR = 0.005) in the recessive model. In the ethnicity-stratified analysis, significant association was observed in the Caucasian population (OR = 1.492; 95% CI: 1.106-2.014; puncorrected = 0.009, pFDR = 0.015), whereas no statistical significant association was detected in the Asian population (adjusted p = 0.124). The results suggested that MCP-1 -2518A>G polymorphism may be associated with susceptibility to CAD, especially in Caucasians.
authors: School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China.
authors: Xiao-Yan
authors: XY
authors: Bai
authors: Shujing
authors: S
authors: Li
authors: Miao
authors: M
authors: Wang
authors: Xinjian
authors: X
authors: Qu
authors: Gaolei
authors: G
authors: Hu
authors: Zhaowei
authors: Z
authors: Xu
authors: Min
authors: M
authors: Chen
authors: Guo-Wei
authors: GW
authors: He
authors: Huijian
authors: H
authors: Wu
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D018932:Chemokine CCL2 / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2
keywords: Coronary artery disease; meta‐analysis; monocyte chemoattractant protein‐1; polymorphism