title: Characterization of Circulating Tumor DNA for Genetic Assessment of solid Tumors.
abstract: Personalized cancer therapy requires characterization of the current status of an individual's cancer, necessitating invasive tumor tissue biopsies at diagnosis, during treatment and at progression. Serial acquisition of solid tumor biopsies during treatment to characterize mutations related to acquired resistance may not be medically feasible. Circulating tumor DNA (ctDNA) in plasma offers a possible noninvasive "real time" tool for tumor characterization, providing accessible genetic biomarkers for cancer diagnosis, prognosis, and response to therapy.
authors: Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.
authors: A J
authors: AJ
authors: Dorner
authors: Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.
authors: S
authors: S
authors: Badola
authors: Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA.
authors: H
authors: H
authors: Niu
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D004247:DNA / Q000097:blood* / Q000235:genetics; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D004247:DNA