title: Changes in lung function according to disease extent before and after pulmonary tuberculosis.
abstract: OBJECTIVE
  To evaluate changes in lung function in individuals before and after treatment for pulmonary tuberculosis (PTB) in relation to extent of disease.
  
  
  METHODS
  Using a retrospective cohort design, changes in and predictors of lung function were evaluated.
  
  
  RESULTS
  A total of 41 patients were included in the final analysis. The median decline in annualised forced expiratory volume in 1 sec (FEV1) was 180.0 ml/year (95%CI 118.9-356.1) in advanced PTB and 94.7 ml/year (95%CI 33.4-147.3) in localised PTB (ΔFEV1% predicted/year 9.4%, 95%CI 4.4-14.0 vs. 3.8%, 95%CI 1.8-6.2). The median decline in annualised forced vital capacity (FVC) was 309.6 ml/year (95%CI 137.0-359.0) in advanced PTB and 101.1 ml/year (95%CI 30.3-219.6) in localised PTB (ΔFVC % predicted/year 7.3%, 95%CI 5.3-12.3 vs. 2.9%, 95%CI 0.9-6.5).
  
  
  CONCLUSIONS
  As the sample size of our study was small, the conclusions could be biased. Nevertheless, our findings show that PTB causes a significant decline in lung function even in localised PTB, whereas advanced PTB was associated with excessive or even higher decline. This study suggests that early diagnosis and treatment of PTB is needed to preserve lung function.
authors: Department of Pulmonary and Critical Care Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of Korea; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
authors: Y
authors: Y
authors: Ko
authors: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
authors: Y-M
authors: YM
authors: Lee
authors: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
authors: H-Y
authors: HY
authors: Lee
authors: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
authors: Y S
authors: YS
authors: Lee
authors: Division of Pulmonary Medicine, CHA University School of Medicine, Gumi CHA Hospital, Gumi, Republic of Korea.
authors: J-W
authors: JW
authors: Song
authors: Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Dankook University Hospital, Cheonan, Republic of Korea.
authors: G-Y
authors: GY
authors: Hong
authors: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
authors: M-Y
authors: MY
authors: Kim
authors: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
authors: H-K
authors: HK
authors: Lee
authors: Department of Radiology, Inje University College of Medicine, Busan, Republic of Korea.
authors: S J
authors: SJ
authors: Choi
authors: Department of Pharmacology and Pharmaco Genomics Research Center, Inje University College of Medicine, Busan, Republic of Korea.
authors: E-J
authors: EJ
authors: Shim
mesh_terms: D000368:Aged; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012016:Reference Values; D056910:Republic of Korea; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000503:physiopathology*; D014797:Vital Capacity / Q000502:physiology*