title: Incidence, clinical and biological characteristics and outcome of secondary acute lymphoblastic leukemia after solid organ or hematologic malignancy.
abstract: Acute lymphoblastic leukemia (ALL) following solid organ or hematologic malignancy (secondary ALL, s-ALL) is not well characterized. We analyzed the characteristics and outcome of patients with s-ALL and compared them with those of patients with de novo- ALL. Of 448 patients, 24 (5%) had previous neoplasia. Sixteen patients had received previous cytotoxic therapy (therapy-associated ALL, t-ALL), and eight had not (antecedent-malignancy ALL, am-ALL). Except for more advanced age in patients with s-ALL, no statistically significant differences were observed in WBC count, CNS involvement, immunophenotype or cytogenetics between the groups, nor in complete remission (t-ALL: 94%; am-ALL: 75%; de novo-ALL: 85%), 3-year remission duration (58%; 50%; 72%), overall survival (71%; 38%; 60%) or event-free survival (53%, 38%; 53%). Our study did not show poor clinical or cytogenetic features or inferior outcome in ALL patients with antecedent neoplastic disease, irrespective of the type of treatment received for the neoplasia.
authors: a Hematology Department of Institut Català d'Oncologia-Hospital Doctor Josep Trueta , Girona , Spain.
authors: Nicholas
authors: N
authors: Kelleher
authors: a Hematology Department of Institut Català d'Oncologia-Hospital Doctor Josep Trueta , Girona , Spain.
authors: David
authors: D
authors: Gallardo
authors: c Hematology Department of Hospital Universitario Virgen del Rocío , Sevilla , Spain.
authors: José
authors: J
authors: González-Campos
authors: d Hematology Department of Hospital Universitario de Salamanca & IBSAL , IBCC, Centro de Investigación del Cáncer, Universidad de Salamanca-CSIC Salamanca , Spain.
authors: Jesús M
authors: JM
authors: Hernández-Rivas
authors: e Hematology Department of Hospital Universitario y Politécnico La Fe , Valencia , Spain.
authors: Pau
authors: P
authors: Montesinos
authors: f Hematology Department of Institut Català d'Oncologia-Hospital Duran i Reynals , L'Hospitalet de Llobregat , Spain.
authors: Josep
authors: J
authors: Sarrá
authors: g Hematology Department of Hospital General Universitario de Alicante , Alicante , Spain.
authors: Cristina
authors: C
authors: Gil
authors: h Hematology Department of Hospital Vall d'Hebron , Barcelona , Spain.
authors: Pere
authors: P
authors: Barba
authors: a Hematology Department of Institut Català d'Oncologia-Hospital Doctor Josep Trueta , Girona , Spain.
authors: Ramon
authors: R
authors: Guàrdia
authors: i Hematology Department of Hospital de Sant Pau , Barcelona , Spain.
authors: Salut
authors: S
authors: Brunet
authors: j Hematology Department of Hospital Central de Asturias , Oviedo , Spain.
authors: Teresa
authors: T
authors: Bernal
authors: k Hematology Department of Hospital Doce de Octubre , Madrid , Spain.
authors: Maria-Pilar
authors: MP
authors: Martínez
authors: l Hematology Department of Hospital del Mar , Barcelona , Spain.
authors: Eugènia
authors: E
authors: Abella
authors: m Hematology Department of Hospital Marqués de Valdecilla , Santander , Spain.
authors: Arantxa
authors: A
authors: Bermúdez
authors: n Hematology Department of Hospital General Universitario de Valencia , Valencia , Spain.
authors: Magdalena
authors: M
authors: Sánchez-Delgado
authors: o Hematology Department of Hospital Son Llàtzer , Palma de Mallorca , Spain.
authors: Cladera
authors: C
authors: Antònia
authors: p Hematology Department of Hospital General Universitario Gregorio Marañón IiGSM , Madrid , Spain.
authors: Jorge
authors: J
authors: Gayoso
authors: q Hematology Department of Hospital Ramón y Cajal , Madrid , Spain.
authors: María
authors: M
authors: Calbacho
authors: b Hematology Department of Institut Català d'Oncologia-Hospital Germans Trias i Pujol . Jose Carreras Research Institute , Badalona , Universitat Autònoma de Barcelona, Spain.
authors: Josep-Maria
authors: JM
authors: Ribera
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D002869:Chromosome Aberrations; D005260:Female; D019337:Hematologic Neoplasms / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D011379:Prognosis; D012008:Recurrence; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Acute lymphoblastic leukemia; cytogenetics; prognosis; secondary