title: [Fecal calprotectin concentration in the differential diagnosis of bowel diseases].
abstract: OBJECTIVE
  To estimate the informative value of a noninvasive fecal (calprotectin) test in the differential diagnosis of bowel diseases.
  
  
  METHODS
  One hundred and forty-two patients who had visited their physicians with intestinal disorders (a change in stool frequency and patterns, abdominal pain) were examined in an open-label multicenter cross-sectional study. The examinees' mean age was 35 ± 2.43 years. Gender- and age-matched comparison groups consisted of healthy individuals and patients with irritable bowel syndrome. Fecal calprotectin (FCP) was determined using a BUHLMANN Calprotectin ELISA kit. All the patients underwent colonoscopy.
  
  
  RESULTS
  In the patients with organic bowel diseases (ulcerative colitis, Crohn's disease, lymphocytic colitis, colonic diverticular disease, colonic adenomas, celiac disease), the concentration of FCP was found to be substantially higher than that in the healthy individuals and patients with irritable bowel syndrome. The highest calprotectin levels were noted in the patients with inflammatory bowel diseases.
  
  
  CONCLUSIONS
  This study demonstrated the high diagnostic value of the calprotectin test for the differential diagnosis of organic and functional bowel diseases.
authors: Novosibirsk Medical University, Ministry of Health of Russia, Novosibirsk, Russia.
authors: M F
authors: MF
authors: Osipenko
authors: Omsk State Medical Academy, Ministry of Health of Russia, Omsk, Russia.
authors: M A
authors: MA
authors: Livzan
authors: Novosibirsk Medical University, Ministry of Health of Russia, Novosibirsk, Russia.
authors: M I
authors: MI
authors: Skalinskaya
authors: Omsk State Medical Academy, Ministry of Health of Russia, Omsk, Russia.
authors: E A
authors: EA
authors: Lyalyukova
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000175:diagnosis*; D039841:Leukocyte L1 Antigen Complex; D008297:Male
chemical_list: D039841:Leukocyte L1 Antigen Complex