title: A review of the anterior visual pathway model and the study of vitamin D in demyelinating disease.
abstract: In recent years, theories about the anti-inflammatory properties of vitamin D in demyelinating disease have been well substantiated by human studies examining relapse reduction, MRI lesion activity and risk of MS conversion. However, the evidence that vitamin D may protect against neurodegeneration has not been established as of yet, and comes with the challenges of a manageable target over a manageable time period. Such challenges might be overcome by the anterior visual pathway (AVP) model of the central nervous system, which allows the non-invasive study (e.g. imaging, electrophysiology and clinical) of form and function within a much shorter time frame than pure clinical activity. This review outlines the state of current knowledge about vitamin D in demyelinating disease, and highlights the potential utility of using the AVP to study its neuroprotective effects.
authors: Department of Clinical Neurosciences Room 1195 - Foothills Hospital 1403 - 29 Street N.W. Calgary Alberta T2N 2T9; Department of Community Health SciencesFaculty of Medicine University of CalgaryTRW Building 3rd Floor 3280 Hospital Drive NW Calgary, Alberta CANADA T2N 4Z6; Hotchkiss Brain InstituteHealth Research Innovation CentreRoom 1A103330 Hospital Drive NWCalgary, Alberta, CanadaT2N 4N1; Calgary Optic Neuritis Research Group (CORE), Canada; University of Calgary, 2500 University Dr NW, Calgary, AB T2N 1N4. Electronic address: jodie.burton@albertahealthservices.ca.
authors: Jodie M
authors: JM
authors: Burton
authors: Department of Clinical Neurosciences Room 1195 - Foothills Hospital 1403 - 29 Street N.W. Calgary Alberta T2N 2T9; Hotchkiss Brain InstituteHealth Research Innovation CentreRoom 1A103330 Hospital Drive NWCalgary, Alberta, CanadaT2N 4N1; Calgary Optic Neuritis Research Group (CORE), Canada; Department of Surgery, University of Calgary Foothills Medical Centre North Tower 10th Floor 1403 - 29th Street NWCalgary, AB T2N 2T9; University of Calgary, 2500 University Dr NW, Calgary, AB T2N 1N4.
authors: Fiona
authors: F
authors: Costello
keywords: Anterior visual pathway; Demyelinating disease; Multiple sclerosis; Neuroprotection; Optic neuritis; Vitamin D