title: Danggui buxue tang inhibits 2,4-dinitrochlorobenzene: induced atopic dermatitis in mice.
abstract: Danggui Buxue Tang (DBT) is a herbal decoction that has been used in Chinese medicine to enhance qi and blood circulation. Previously, we found that DBT can suppress allergy-related asthma in mice, leading us to hypothesize that DBT might ameliorate allergy disease. In this study, we evaluated whether DBT can attenuate atopic dermatitis (AD) symptoms and have an anti-inflammatory effect on AD-like mice. The dorsal skin of female mice was shaved and sensitized cutaneously (skin smear) with 1-chloro-2,4-dinitrobenzene. Mice were then given various doses of DBT from days 14 to 29 cutaneously. DBT treatment suppressed ear swelling and skin inflammation and decreased mast cell and eosinophil infiltration into skin and ear tissue. DBT also inhibited levels of IgE and Th2-associated cytokine levels in serum. These results demonstrate that cutaneous administration of DBT reduced the development of AD-like skin lesions in mice.
authors: Department of Nutrition, I-Shou University, Yanchao District, Kaohsiung City, Taiwan.
authors: Li-Wen
authors: LW
authors: Fang
authors: Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan ; Nutritional Science Department, Fu Jen Catholic University, New Taipei City, Taiwan.
authors: Chao-Chun
authors: CC
authors: Cheng
authors: Graduate Institute of Biotechnology, Chinese Culture University, Yang-Ming-Shan, Taipei, Taiwan.
authors: Tzann-Shun
authors: TS
authors: Hwang
authors: Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan ; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan.
authors: Wen-Chung
authors: WC
authors: Huang
authors: Department of Nursing, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan.
authors: Chian-Jiun
authors: CJ
authors: Liou
authors: Center for General Education, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan.
authors: Wen-Chyuan
authors: WC
authors: Chen
authors: Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan ; Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Guishan District, Taoyuan City, Taiwan.
authors: Shu-Ju
authors: SJ
authors: Wu