title: A 2H-tetrahydropyran derivative and bioactive constituents from the bark of Goniothalamus elegants Ast.
abstract: A new 2H-tetrahydropyran derivative, 6-epi-goniothalesdiol A (1), together with nine known styryllactones (2-10) and five known aristolactams (11-15) were isolated from the bark of Goniothalamus elegants Ast. The structures were elucidated by spectroscopic methods. The isolated compounds were evaluated for their cytotoxicity toward the KB, MCF7 and NCI-H187 cell lines as well as antimalarial and antimycobacterial activities. Compounds 4 and 10 showed strong activity against all three human cancer cell lines with IC50 values in the range of 0.538 to 4.25 μg/ml, while compounds 2, 4, 10 and 14 showed potent cytotoxicity against NCI-H187 with IC50 values in the range of 0.072 to 2.17 μg/ml. In addition, compounds 4, 6, 7, 9, 10 and 13 showed strong antiplasmodial activity with IC50 in the range of 2.28 to 5.89 μg/ml.
authors: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Nattawut
authors: N
authors: Suchaichit
authors: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Kwanjai
authors: K
authors: Kanokmedhakul
authors: Department of Applied Chemistry, Faculty of Sciences and Liberal Arts, Rajamangala University of Technology Isan, Nakhon Ratchasima 30000, Thailand.
authors: Natcha
authors: N
authors: Panthama
authors: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Kitisak
authors: K
authors: Poopasit
authors: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address: mpanaw@kku.ac.th.
authors: Panawan
authors: P
authors: Moosophon
authors: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Somdej
authors: S
authors: Kanokmedhakul
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005663:Furans / Q000302:isolation & purification / Q000494:pharmacology*; D054335:Goniothalamus / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; C512388:goniothalesdiol
keywords: Annonaceae; Aristolactam; Cytotoxicity; Goniothalamus elegants; Styryllactone; Tetrahydropyran