title: Single cusp replacement in patients with ventricular septal defect and aortic insufficiency.
abstract: OBJECTIVE
  The aim of this study was to analyze the mid- and long-term outcome of single cusp replacement in patients with ventricular septal defect and aortic insufficiency.
  
  
  METHODS
  From September 2005 through March 2014, 172 patients underwent single cusp replacement and ventricular septal defect (VSD) closure. The median age was 19.5 years (range, 9 months to 67 years). Additional techniques were used to repair associated anomalies including sinus of Valsalva aneurysm, patent ductus arteriosus, patent foramen ovale, subaortic membrane, and intramural coronary artery.
  
  
  RESULTS
  One patient with large left ventricle (preoperative end-diastolic diameter: 9.8 cm) died after the procedure from incurable heart failure. Four patients required a second pump run for residual aortic insufficiency (AI) (two patients, 1.16%) and residual VSD (two patients, 1.16%). Four patients required re-exploration for postoperative bleeding or cardiac tamponade. Mean follow-up was 53.27 ± 25.37 months (median, 56.5 months; range, 3 to 104 months). Redo aortic valve surgery was performed in three patients. Three patients had moderate-severe AI during the following period without reoperation. There was no post-operative endocarditis.
  
  
  CONCLUSIONS
  Single cusp replacement can be safely used in patients with VSD-AI.
authors: Department of Cardiac Surgery, Asia Heart Hospital, Wuhan, P.R. China.
authors: Laichun
authors: L
authors: Song
authors: Department of Cardiac Surgery, Asia Heart Hospital, Wuhan, P.R. China.
authors: Zhengdong
authors: Z
authors: Hua
authors: Department of Cardiac Surgery, Asia Heart Hospital, Wuhan, P.R. China.
authors: Xufa
authors: X
authors: Chen
authors: Department of Cardiac Surgery, Asia Heart Hospital, Wuhan, P.R. China.
authors: Huadong
authors: H
authors: Yu
authors: Department of Cardiac Surgery, Asia Heart Hospital, Wuhan, P.R. China.
authors: Bo
authors: B
authors: Wang
authors: Department of Cardiac Surgery, Asia Heart Hospital, Wuhan, P.R. China.
authors: Jing
authors: J
authors: Jin
authors: Asia Heart Hospital, Wuhan, P.R. China.
authors: Xin
authors: X
authors: Zhou
authors: Department of Cardiac Surgery, Asia Heart Hospital, Wuhan, P.R. China.
authors: Jihui
authors: J
authors: Fang
authors: Department of Cardiac Surgery, Asia Heart Hospital, Wuhan, P.R. China.
authors: Liang
authors: L
authors: Tao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000379:methods*; D018376:Cardiovascular Abnormalities / Q000150:complications / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult