title: Primary cutaneous B-cell lymphoma (non-leg type) has excellent outcomes even after very low dose radiation as single-modality therapy.
abstract: Primary cutaneous B cell lymphomas (PCBCL) are rare; although data on outcomes and treatment are limited, traditionally they have been treated with radiation doses in excess of 24 Gy. We retrospectively identified and reviewed all cases of PCBCL treated at our institution from 2002-2014. Thirty-nine patients with PCBCL (42 lesions) were identified. Radiation was the only treatment for most patients. All lesions had a complete response and none had in-field failures; seven patients had out-of-field relapses, three of which were salvaged with radiation therapy. No differences in PFS or OS were found for patients given low-dose (≤ 12 Gy) versus high-dose (> 12 Gy) radiation. PCBCL is an indolent entity with a long clinical course and excellent response to radiation therapy and successful salvage of recurrent disease, even when doses are as low as 4 Gy. Given the above findings, we recommend the initial use of low-dose irradiation for PCBCL.
authors: a Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.|b Department of Radiation Oncology , The University of Texas Medical Branch at Galveston , Galveston , TX , USA.
authors: Mani
authors: M
authors: Akhtari
authors: a Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Jay Paul
authors: JP
authors: Reddy
authors: a Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Chelsea C
authors: CC
authors: Pinnix
authors: a Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Pamela K
authors: PK
authors: Allen
authors: a Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Eleanor M
authors: EM
authors: Osborne
authors: a Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Jillian R
authors: JR
authors: Gunther
authors: a Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Sarah A
authors: SA
authors: Milgrom
authors: a Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Grace L
authors: GL
authors: Smith
authors: a Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Christine F
authors: CF
authors: Wogan
authors: c Department of Lymphoma & Myeloma , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Nathan
authors: N
authors: Fowler
authors: c Department of Lymphoma & Myeloma , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Maria Alma
authors: MA
authors: Rodriguez
authors: a Department of Radiation Oncology , The University of Texas MD Anderson Cancer Center , Houston , TX , USA.
authors: Bouthaina
authors: B
authors: Dabaja
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000401:mortality / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000532:radiotherapy*; D016896:Treatment Outcome; D055815:Young Adult
keywords: B cell; follicle center; marginal zone; radiation therapy; skin lymphoma