title: Modeling universal dynamics of cell spreading on elastic substrates.
abstract: A three-dimensional (3D) multiscale moving contact line model is combined with a soft matter cell model to study the universal dynamics of cell spreading over elastic substrates. We have studied both the early stage and the late stage cell spreading by taking into account the actin tension effect. In this work, the cell is modeled as an active nematic droplet, and the substrate is modeled as a St. Venant Kirchhoff elastic medium. A complete 3D simulation of cell spreading has been carried out. The simulation results show that the spreading area versus spreading time at different stages obeys specific power laws, which is in good agreement with experimental data and theoretical prediction reported in the literature. Moreover, the simulation results show that the substrate elasticity may affect force dipole distribution inside the cell. The advantage of this approach is that it combines the hydrodynamics of actin retrograde flow with moving contact line model so that it can naturally include actin tension effect resulting from actin polymerization and actomyosin contraction, and thus it might be capable of simulating complex cellular scale phenomenon, such as cell spreading or even crawling.
authors: Department of Civil and Environmental Engineering, University of California, Berkeley, CA, 94720, USA.
authors: Houfu
authors: H
authors: Fan
authors: Department of Civil and Environmental Engineering, University of California, Berkeley, CA, 94720, USA. shaofan@berkeley.edu.
authors: Shaofan
authors: S
authors: Li
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000502:physiology*; D013314:Stress, Mechanical
chemical_list: D020409:Molecular Motor Proteins
keywords: Adhesive contact; Cell crawling; Cell spreading; Moving contact line; Soft matter