title: [Correlation between follicle-stimulating hormone and total procollagen I N-terminal propeptide in perimenopausal women].
abstract: To investigate the correlation between serum levels of follicle-stimulating hormone (FSH) and total procollagen I N-terminal propeptide (TP1NP) in perimenopausal women.
  
  
  
  Total 274 women aged 33~60 y with perimenopausal period were enrolled in this study. Serum levels of FSH and TP1NP were detected by electrochemiluminescence.
  
  
  
  In 274 perimenopausal women, the average level of TP1NP was (48.99±20.31) ng/mL, which was positively correlated with FSH level (r=0.159, P=0.009). In 40-50 age group, TP1NP level in women with FSH<40 mIU/mL was lower than that in those with FSH≥40mIU/mL [(35.05±18.11) ng/mL vs (51.33±24.67) ng/mL; t=-2.954, P=0.004]. However, in <40 and 50-60 age groups, there were no significant differences in TP1NP levels between patients with FSH<40 mIU/mL and those with FSH≥40 mIU/mL (t=-0.063, P=0.950; t=1.177, P=0.242). Multiple linear regression analysis showed that standardized coefficients of age variable was 0.047 (P=0.448) and standardized coefficients of FSH variable was 0.146 (P=0.019).
  
  
  
  TP1NP levels showed a certain correlation with FSH in perimenopausal women, especially for women aged 40-50, indicating that high FSH levels may be important factors for osteoporosis in postmenopausal women.
authors: Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China;Department of Gynecology, Second Hospital of Jiaxing, Jiaxing 314000,China.
authors: Bing
authors: B
authors: Wang
authors: Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
authors: Yan
authors: Y
authors: Chen
authors: Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
authors: Yang
authors: Y
authors: Song
authors: Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
authors: En-Sheng
authors: ES
authors: Wang
authors: Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
authors: Dan
authors: D
authors: Zheng
authors: Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
authors: Fan
authors: F
authors: Qu
authors: Department of Gynecology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
authors: Jian-Hong
authors: JH
authors: Zhou
mesh_terms: D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D047648:Perimenopause / Q000097:blood*; D011347:Procollagen / Q000097:blood*
chemical_list: D010446:Peptide Fragments; D011347:Procollagen; C047202:procollagen Type I N-terminal peptide; D005640:Follicle Stimulating Hormone