title: A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis.
abstract: It is now appreciated that sphingolipids constitute a rich class of bioactive molecules that include ceramide, sphingosine, and sphingosine 1‐phosphate whose formation is controlled by a network of highly regulated enzymes (Hannun & Obeid, 2008). Notably, several stress stimuli induce the production of ceramide, which, as a single entity, has been traditionally associated with apoptotic and growth suppressive functions. However, recent data clearly suggest that this simplistic formulation is no longer tenable.
authors: Department of Medicine, The Stony Brook Cancer Center, Stony Brook, NY, USA.
authors: Yusuf A
authors: YA
authors: Hannun
authors: Department of Medicine, The Stony Brook Cancer Center, Stony Brook, NY, USA.
authors: Benjamin
authors: B
authors: Newcomb
mesh_terms: D000818:Animals; D008545:Melanoma / Q000556:secondary*; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism*
chemical_list: D013108:Sphingomyelin Phosphodiesterase