title: A comparison of liver fat content as determined by magnetic resonance imaging-proton density fat fraction and MRS versus liver histology in non-alcoholic fatty liver disease.
abstract: Many imaging methods have been defined for quantification of hepatic steatosis in non-alcoholic fatty liver disease (NAFLD). However, studies comparing the efficiency of magnetic resonance imaging-proton density fat fraction (MRI-PDFF), magnetic resonance spectroscopy (MRS), and liver histology for quantification of liver fat content are limited.
  
  
  
  To compare the efficiency of MRI-PDFF and MRS in the quantification of liver fat content in individuals with NAFLD.
  
  
  
  A total of 19 NAFLD patients underwent MRI-PDFF, MRS, and liver biopsy for quantification of liver fat content. The MR examinations were performed on a 1.5 HDx MRI system. The MRI protocol included T1-independent volumetric multi-echo gradient-echo imaging with T2* correction and spectral fat modeling and MRS with STEAM technique.
  
  
  
  A close correlation was observed between liver MRI-PDFF- and histology- determined steatosis (r = 0.743, P < 0.001) and between liver MRS- and histology-determined steatosis (r = 0.712, P < 0.001), with no superiority between them (ƶ = 0.19, P = 0.849). For quantification of hepatic steatosis, a high correlation was observed between the two MRI methods (r = 0.986, P < 0.001). MRI-PDFF and MRS accurately differentiated moderate/severe steatosis from mild/no hepatic steatosis (P = 0.007 and 0.013, respectively), with no superiority between them (AUCMRI-PDFF = 0.881 ± 0.0856 versus AUCMRS = 0.857 ± 0.0924, P = 0.461).
  
  
  
  Both MRI-PDFF and MRS can be used for accurate quantification of hepatic steatosis.
authors: Hacettepe University, School of Medicine, Department of Radiology, Liver Imaging Team, Ankara, Turkey.
authors: Ilkay S
authors: IS
authors: Idilman
authors: Department of Gastroenterology, Ankara University, Faculty of Medicine, Ankara, Turkey.
authors: Onur
authors: O
authors: Keskin
authors: General Electric Healthcare, Istanbul, Turkey.
authors: Azim
authors: A
authors: Celik
authors: Department of Pathology, Ankara University, Faculty of Medicine, Ankara, Turkey.
authors: Berna
authors: B
authors: Savas
authors: Department of Biostatistics, Ankara University, Faculty of Medicine, Ankara, Turkey.
authors: Atilla Halil
authors: AH
authors: Elhan
authors: Department of Gastroenterology, Ankara University, Faculty of Medicine, Ankara, Turkey.
authors: Ramazan
authors: R
authors: Idilman
authors: Hacettepe University, School of Medicine, Department of Radiology, Liver Imaging Team, Ankara, Turkey musturayk@yahoo.com.
authors: Musturay
authors: M
authors: Karcaaltincaba
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000473:pathology*; D011522:Protons; D015203:Reproducibility of Results; D012720:Severity of Illness Index
chemical_list: D011522:Protons
keywords: Non-alcoholic fatty liver disease; liver biopsy; magnetic resonance imaging (MRI); magnetic resonance spectroscopy (MRS); proton density fat fraction (PDFF)