title: Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome?
abstract: This multi-center, cross-sectional study investigated the association between serum testosterone (T) levels, serum sex hormone-binding globulin (SHBG) levels, and the risk of metabolic syndrome (MS) in 3332 adult Chinese men. The prevalence of MS was 34.7%, and men with MS had lower serum levels of total T (TT) and SHBG than those without MS (P < 0.001). There was no significant difference in serum free T (FT) levels between subjects with and without MS (P = 0.627). In logistic regression analysis, the association between MS and serum SHBG levels persisted after adjusting for age, body mass index (BMI), smoking and drinking status, and serum TT (odds ratio [OR] 0.962, 95% confidence interval [95% CI] 0.954-0.969, P< 0.01). However, the association between serum TT level and the risk of MS was weak after adjusting for age, BMI, SHBG level, and smoking and drinking status (OR 0.981, 95% CI 0.960-1.007). Our study reveals that both serum TT and SHBG levels, but not serum FT, are inversely associated with the prevalence of MS and that serum SHBG is an independent and dominant risk factor for MS.
authors: Yi-Hong
authors: YH
authors: Yang
authors: Ming-Jia
authors: MJ
authors: Zhao
authors: Shan-Jie
authors: SJ
authors: Zhou
authors: Wen-Hong
authors: WH
authors: Lu
authors: Xiao-Wei
authors: XW
authors: Liang
authors: Cheng-Liang
authors: CL
authors: Xiong
authors: Chang-Chun
authors: CC
authors: Wan
authors: Department of Andrology, Nanjing General Hospital of Nanjing Command, PLA, Nanjing 210002, China.
authors: Xue-Jun
authors: XJ
authors: Shang
authors: Graduate School of Peking Union Medical College, Beijing 100730; National Health and Family Planning Key Laboratory of Male Reproductive Health, Department of Male Clinical Research, National Research Institute for Family Planning, Beijing 100081, China.
authors: Yi-Qun
authors: YQ
authors: Gu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*; D055815:Young Adult
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone