title: Effects of prenatal stress on anxiety-like behavior and nociceptive response in rats.
abstract: We assess the anxiety-like behavior in the open field and elevated plus maze tests and measure the nociceptive response in the tail flick test following prenatal stress exposure in adult male and female Wistar rats. In both behavioral anxiety tests, prenatal stress increased the anxiety-like behavior in male PS rats, but not in females suggesting a strong sex-dependent anxiogenic effect. The tail flick results showed a hypersensitivity to pain in male and female PS rats with a subtle gender difference. These findings suggest that prenatal stress is an important risk factor for multiple mental disorders.
authors: Department of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco 20100, Morocco.
authors: N
authors: N
authors: Said
authors: Department of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco 20100, Morocco.
authors: S
authors: S
authors: Lakehayli
authors: Laboratory of Clinical Neurosciences and Mental Health, Faculty of Medicine and Pharmacy of Casablanca Casablanca, Morocco 20100, Morocco.
authors: O
authors: O
authors: Battas
authors: Department of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco 20100, Morocco.
authors: F
authors: F
authors: Hakkou
authors: Department of Pharmacology, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, Morocco 20100, Morocco.
authors: A
authors: A
authors: Tazi
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000209:etiology*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D018782:Maze Learning; D009483:Neuropsychological Tests; D059225:Nociception / Q000502:physiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology* / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology; D012727:Sex Characteristics; D013315:Stress, Psychological / Q000150:complications*
keywords: Prenatal stress; Wistar rats; analgesia; anxiety; elevated plus maze; open field; sex differences; tail flick