title: Procedural outcomes of patients with calcified lesions treated with bioresorbable vascular scaffolds.
abstract: OBJECTIVE
  To compare the feasibility, procedural and clinical outcomes after implantation of bioresorbable vascular scaffolds (BVS) in patients with calcified lesions.
  
  
  RESULTS
  We assessed the feasibility of BVS implantation and procedural outcomes in patients with and without calcific lesions. The primary outcome was angiographic and procedural success. Secondary outcomes included major adverse cardiovascular events (MACE). Of 163 patients, 62 (38%) had calcified lesions. Patients with calcific lesions had a higher prevalence of diabetes (35.5% vs. 22.8%, p=0.078) and chronic kidney disease (31.1% vs. 13.9%, p=0.008), and higher SYNTAX scores (18.9±9.7 vs. 15.1±9.0, p=0.017). Calcific lesions required longer procedures (126.4±39.8 vs. 106.9±37.1 min, p=0.015), more frequent use of dedicated devices and IVUS. Acute gain (1.83±0.6 vs. 1.86±0.6, p=0.732) and angiographic success were similar (98% non-calcific vs. 95.2% calcific, p=0.369), whereas procedural success was reduced in patients with calcific lesions (94.1% vs. 83.9%, p=0.034) due to higher rates of periprocedural myocardial infarction (MI) (5% vs. 13.1%, p=0.067). During the median follow-up time of 14 months MACE rates (10.9% non-calcific vs. 12.9% calcific, plog-rank=0.546) were similar.
  
  
  CONCLUSIONS
  Treating calcific lesions with BVS is feasible with high angiographic success rates, at the expense of longer procedure times, aggressive lesion preparation and increased rates of periprocedural MI.
authors: National Heart and Lung Institute, Imperial College London, London, United Kingdom.
authors: Vasileios F
authors: VF
authors: Panoulas
authors: Tadashi
authors: T
authors: Miyazaki
authors: Katsumasa
authors: K
authors: Sato
authors: Toru
authors: T
authors: Naganuma
authors: Alessandro
authors: A
authors: Sticchi
authors: Hiroyoshi
authors: H
authors: Kawamoto
authors: Filippo
authors: F
authors: Figini
authors: Alaide
authors: A
authors: Chieffo
authors: Mauro
authors: M
authors: Carlino
authors: Matteo
authors: M
authors: Montorfano
authors: Azeem
authors: A
authors: Latib
authors: Antonio
authors: A
authors: Colombo
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D015897:Comorbidity; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D011474:Prosthesis Design; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional; D061205:Vascular Calcification / Q000000981:diagnostic imaging / Q000628:therapy*