title: Can palliative radiotherapy influence prostate-specific antigen response in patients with castrate-resistant prostate cancer treated with systemic therapy (chemotherapy or abiraterone)?-a report of three cases.
abstract: Palliative radiotherapy (pRT) is primarily employed for palliation of bone pain in patients with castrate-resistant prostate cancer (CRPC). However, evidence that pRT influences prostate-specific antigen response in patients with CRPC on systemic therapy is lacking. We describe three cases of CRPC progressing after treatment with docetaxel (n=2) and abiraterone (n=1), who responded unusually after pRT for bone pain with the development of a significant biochemical response and restoration of response to systemic therapy. The possibility of pRT influencing metastatic disease in CRPC has not been previously reported, and raises the possibility of radiation-induced modulation of anti-tumor immune response mechanisms that may play a role in the restoration of response to systemic treatment.
authors: 1 Department of Clinical Oncology, Castle Hill Hospital, Hull and East Yorkshire, NHS Trust, Cottingham, East Riding of Yorkshire, HU16 5JQ, UK ; 2 Department of Urology, Scarborough District General Hospital, Scarborough ON M1P 2V5, UK.
authors: Mohan
authors: M
authors: Hingorani
authors: 1 Department of Clinical Oncology, Castle Hill Hospital, Hull and East Yorkshire, NHS Trust, Cottingham, East Riding of Yorkshire, HU16 5JQ, UK ; 2 Department of Urology, Scarborough District General Hospital, Scarborough ON M1P 2V5, UK.
authors: Sanjay
authors: S
authors: Dixit
authors: 1 Department of Clinical Oncology, Castle Hill Hospital, Hull and East Yorkshire, NHS Trust, Cottingham, East Riding of Yorkshire, HU16 5JQ, UK ; 2 Department of Urology, Scarborough District General Hospital, Scarborough ON M1P 2V5, UK.
authors: Pattu
authors: P
authors: Pugazhenthi
authors: 1 Department of Clinical Oncology, Castle Hill Hospital, Hull and East Yorkshire, NHS Trust, Cottingham, East Riding of Yorkshire, HU16 5JQ, UK ; 2 Department of Urology, Scarborough District General Hospital, Scarborough ON M1P 2V5, UK.
authors: Simon
authors: S
authors: Hawkyard
authors: 1 Department of Clinical Oncology, Castle Hill Hospital, Hull and East Yorkshire, NHS Trust, Cottingham, East Riding of Yorkshire, HU16 5JQ, UK ; 2 Department of Urology, Scarborough District General Hospital, Scarborough ON M1P 2V5, UK.
authors: Andrew
authors: A
authors: Robertson
authors: 1 Department of Clinical Oncology, Castle Hill Hospital, Hull and East Yorkshire, NHS Trust, Cottingham, East Riding of Yorkshire, HU16 5JQ, UK ; 2 Department of Urology, Scarborough District General Hospital, Scarborough ON M1P 2V5, UK.
authors: Richard
authors: R
authors: Khafagy
keywords: Prostate cancer; chemotherapy; palliative; radiotherapy