title: External quality control for dried blood spot-based C-reactive protein assay: experience from the indonesia family life survey and the longitudinal aging study in India.
abstract: Measurement of C-reactive protein (CRP), a marker of inflammation, in dried blood spots has been increasingly incorporated into community-based social surveys internationally. Although the dried blood spot-based CRP assay protocol has been validated in the United States, it remains unclear whether laboratories in other less-developed countries can generate CRP results of similar quality. We therefore conducted external quality monitoring for dried blood spot-based CRP measurement for the Indonesia Family Life Survey and the Longitudinal Aging Study in India. Our results show that dried blood spot-based CRP results in these two countries have excellent and consistent correlations with serum-based values and dried blood spot-based results from the reference laboratory in the United States. Even though the results from duplicate samples may have fluctuations in absolute values over time, the relative order of C-reactive protein levels remains similar, and the estimates are reasonably precise for population-based studies that investigate the association between socioeconomic factors and health.
authors: a Division of Geriatric Medicine, David Geffen School of Medicine , University of California, Los Angeles , Los Angeles , California , USA.
authors: Peifeng
authors: P
authors: Hu
authors: Elizabeth H
authors: EH
authors: Herningtyas
authors: Varsha
authors: V
authors: Kale
authors: Eileen M
authors: EM
authors: Crimmins
authors: Arun R
authors: AR
authors: Risbud
authors: Heather
authors: H
authors: McCreath
authors: Jinkook
authors: J
authors: Lee
authors: John
authors: J
authors: Strauss
authors: Jennifer C
authors: JC
authors: O'Brien
authors: David E
authors: DE
authors: Bloom
authors: Teresa E
authors: TE
authors: Seeman
mesh_terms: D001681:Biological Assay / Q000592:standards*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D003906:Developing Countries / Q000706:statistics & numerical data; D059788:Dried Blood Spot Testing / Q000592:standards*; D005191:Family Characteristics; D006801:Humans; D007194:India; D007214:Indonesia; D008137:Longitudinal Studies; D011786:Quality Control; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein