title: Glucose and triglyceride excursions following a standardized meal in individuals with diabetes: ELSA-Brasil study.
abstract: OBJECTIVE
  To assess glucose and triglyceride excursions 2 hours after the ingestion of a standardized meal and their associations with clinical characteristics and cardiovascular complications in individuals with diabetes.
  
  
  METHODS
  Blood samples of 898 subjects with diabetes were collected at fasting and 2 hours after a meal containing 455 kcal, 14 g of saturated fat and 47 g of carbohydrates. Self-reported morbidity, socio-demographic characteristics and clinical measures were obtained by interview and exams performed at the baseline visit of the ELSA-Brasil cohort study.
  
  
  RESULTS
  Median (interquartile range, IQR) for fasting glucose was 150.5 (123-198) mg/dL and for fasting triglycerides 140 (103-199) mg/dL. The median excursion for glucose was 45 (15-76) mg/dL and for triglycerides 26 (11-45) mg/dL. In multiple linear regression, a greater glucose excursion was associated with higher glycated hemoglobin (10.7, 95% CI 9.1-12.3 mg/dL), duration of diabetes (4.5; 2.6-6.4 mg/dL, per 5 year increase), insulin use (44.4; 31.7-57.1 mg/dL), and age (6.1; 2.5-9.6 mg/dL, per 10 year increase); and with lower body mass index (-5.6; -8.4- -2.8 mg/dL, per 5 kg/m2 increase). In adjusted logistic regression models, a greater glucose excursion was marginally associated with the presence of cardiovascular comorbidities (coronary heart disease, myocardial infarction and angina) in those with obesity.
  
  
  CONCLUSIONS
  A greater postprandial glycemic response to a small meal was positively associated with indicators of a decreased capacity for insulin secretion and negatively associated with obesity. No pattern of response was observed with a greater postprandial triglyceride excursion.
authors: Bárbara P
authors: BP
authors: Riboldi
authors: Vivian C
authors: VC
authors: Luft
authors: Cristina D
authors: CD
authors: de Castilhos
authors: Letícia O
authors: LO
authors: de Cardoso
authors: Maria I
authors: MI
authors: Schmidt
authors: Sandhi M
authors: SM
authors: Barreto
authors: Maria F
authors: MF
authors: de Sander
authors: Sheila M
authors: SM
authors: Alvim
authors: Bruce B
authors: BB
authors: Duncan
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001938:Brazil / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D062407:Meals / Q000502:physiology*; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology*; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D014280:Triglycerides