title: [Observation of animal model of life cycle of Angiostrongylus cantonensis].
abstract: OBJECTIVE
  To observe the effect of artificially construction of the life cycle of Angiostrongylus cantonensis in the laboratory condition, so as to provide the basis for the research of angiostrongyliasis.
  
  
  METHODS
  SD rats were infected orally with the third-stage larvae of A. cantonensis collected from infected Pomacea canaliculata. Six weeks after the infection, the first-stage larvae were isolated and counted from fresh feces of the rats and then were used to infect P. canaliculata. Three weeks later, the snails were dissected for counting the third-staged larvae of A. cantonensis.
  
  
  RESULTS
  The first-stage larvae were detected in the feces of the rats 6 weeks after the infection, and the third-staged larvae were successfully isolated after the infection of P. canaliculata.
  
  
  CONCLUSIONS
  The animal model of the entire life cycle of A. cantonensis is successfully established in the laboratory with the infection of 50 larvae per rat.
authors: Jian-Ming
authors: JM
authors: Wang
authors: Jin-Jun
authors: JJ
authors: Xu
authors: Yong-Hua
authors: YH
authors: Zhou
authors: Jian-Ping
authors: JP
authors: Tao
mesh_terms: D017185:Angiostrongylus cantonensis / Q000254:growth & development* / Q000502:physiology; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007814:Larva / Q000254:growth & development / Q000502:physiology; D008018:Life Cycle Stages; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012908:Snails / Q000469:parasitology; D017206:Strongylida Infections / Q000469:parasitology*