title: Improving multiple sequence alignment by using better guide trees.
abstract: Progressive sequence alignment is one of the most commonly used method for multiple sequence alignment. Roughly speaking, the method first builds a guide tree, and then aligns the sequences progressively according to the topology of the tree. It is believed that guide trees are very important to progressive alignment; a better guide tree will give an alignment with higher accuracy. Recently, we have proposed an adaptive method for constructing guide trees. This paper studies the quality of the guide trees constructed by such method. Our study showed that our adaptive method can be used to improve the accuracy of many different progressive MSA tools. In fact, we give evidences showing that the guide trees constructed by the adaptive method are among the best.
authors: Qing
authors: Q
authors: Zhan
authors: Yongtao
authors: Y
authors: Ye
authors: Tak-Wah
authors: TW
authors: Lam
authors: Siu-Ming
authors: SM
authors: Yiu
authors: Yadong
authors: Y
authors: Wang
authors: Hing-Fung
authors: HF
authors: Ting
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D030541:Databases, Genetic; D019143:Evolution, Molecular; D006801:Humans; D010802:Phylogeny; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA; D012984:Software