title: Brain rhythms connect impaired inhibition to altered cognition in schizophrenia.
abstract: In recent years, schizophrenia research has focused on inhibitory interneuron dysfunction at the level of neurobiology and on cognitive impairments at the psychological level. Reviewing both experimental and computational findings, we show how the temporal structure of the activity of neuronal populations, exemplified by brain rhythms, can begin to bridge these levels of complexity. Oscillations in neuronal activity tie the pathophysiology of schizophrenia to alterations in local processing and large-scale coordination, and these alterations in turn can lead to the cognitive and perceptual disturbances observed in schizophrenia.
authors: Cognitive Rhythms Collaborative , Boston University; Department of Mathematics & Statistics, Boston University. Electronic address: benpolletta@gmail.com.
authors: Benjamin R
authors: BR
authors: Pittman-Polletta
authors: Cognitive Rhythms Collaborative , Boston University; Department of Psychiatry, Beth Israel Medical Center, Harvard Medical School, Boston, Massachusetts.
authors: Bernat
authors: B
authors: Kocsis
authors: Department of Mathematics & Statistics, Boston University.
authors: Sujith
authors: S
authors: Vijayan
authors: Cognitive Rhythms Collaborative , Boston University; Department of Neuroscience, Hull York Medical School, York University, York, United Kingdom.
authors: Miles A
authors: MA
authors: Whittington
authors: Cognitive Rhythms Collaborative , Boston University; Department of Mathematics & Statistics, Boston University.
authors: Nancy J
authors: NJ
authors: Kopell
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D058256:Brain Waves / Q000502:physiology*; D059330:GABAergic Neurons / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007395:Interneurons / Q000502:physiology; D009433:Neural Inhibition; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology*; D012565:Schizophrenic Psychology
keywords: Brain rhythms; Cognition; Functional connectivity; Inhibitory interneurons; Schizophrenia; Temporal coding