title: Acebrophylline-induced angioedema.
abstract: A 53-year-old woman visited her physician complaining of acute breathlessness and productive cough. Her medications included budesonide and formoterol for asthma, fixed-dose combination aspirin 150 mg + clopidogrel 75 mg + atorvastatin 20 mg for ischemic heart disease. History revealed that she had allergic rhinitis and was hypersensitive to penicillins. The patient was prescribed acebrophylline (ABP). Six hours after ABP therapy she presented with generalized urticarial lesions, swelling of hands, feet, lips and face, suggestive of angioedema. ABP was stopped immediately, and the patient was treated symptomatically. This case was categorized as probable as per standard causality assessment scale.
authors: Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors: Sanitha
authors: S
authors: Kuriachan
authors: Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors: Mohan Babu V
authors: MB
authors: Amberkar
authors: Department of Pulmonary Medicine, Kasturba Medical College and Hospital, Manipal University, Manipal, Karnataka, India.
authors: Manu K
authors: MK
authors: Mohan
authors: Department of Pulmonary Medicine, Kasturba Medical College and Hospital, Manipal University, Manipal, Karnataka, India.
authors: Hameed Aboobackar
authors: HA
authors: Shahul
authors: Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors: Meenakumari Kamal
authors: MK
authors: Kishore
mesh_terms: D000551:Ambroxol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000799:Angioedema / Q000139:chemically induced* / Q000628:therapy; D001249:Asthma / Q000150:complications / Q000188:drug therapy; D001991:Bronchitis / Q000150:complications / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D013806:Theophylline / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D001993:Bronchodilator Agents; C077110:ambroxol-theophylline-7-acetate; D000551:Ambroxol; D013806:Theophylline
keywords: Allergic; Naranjo's scale; de-challenge; urticarial lesions