title: Mania following use of ibogaine: A case series.
abstract: BACKGROUND
  Ibogaine is a naturally occurring hallucinogen with postulated anti-addictive qualities. While illegal domestically, a growing number of individuals have sought it out for treatment of opiate dependence, primarily in poorly regulated overseas clinics. Existing serious adverse events include cardiac and vestibular toxicity, though ours is the first report of mania stemming from its use.
  
  
  OBJECTIVE
  To report on a case series of psychiatric emergency room patients whose unregulated use of ibogaine resulted in mania in three patients with no prior diagnosis of bipolar illness.
  
  
  METHODS
  Review and summarize charts of three cases. Relevant literature was also reviewed for discussion.
  
  
  RESULTS
  Two cases of reported ibogaine ingestion for self-treatment of addictions, and one for psycho-spiritual experimentation resulted in symptoms consistent with mania. No prior reports of mania were found in the literature, and the literature suggests growing popularity of ibogaine's use.
  
  
  CONCLUSIONS
  The three cases presented demonstrate a temporal association between ibogaine ingestion and subsequent development of mania.
  
  
  CONCLUSIONS
  In light of these cases, clinicians faced with a new onset mania may benefit from careful substance use and treatment history, specifically regarding opiates. In the vulnerable and often desperate addiction population, in particular, the number of patients seeking this treatment appears to be growing. We advise clinicians to be prepared for discussing the safety, efficacy, and paucity of good data regarding ibogaine with patients who may be considering its use. (Am J Addict 2015;24:203-205).
authors: Department of Psychiatry, Sepulveda VA, University of California at Los Angeles, North Hills, California.
authors: Cole J
authors: CJ
authors: Marta
authors: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington.
authors: Wesley C
authors: WC
authors: Ryan
authors: Department of Psychiatry and Behavioral Sciences, Olive View Medical Center, University of California at Los Angeles, Los Angeles, California.
authors: Alex
authors: A
authors: Kopelowicz
authors: Department of Psychiatry, Sepulveda VA, University of California at Los Angeles, North Hills, California.
authors: Ralph J
authors: RJ
authors: Koek
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D003906:Developing Countries; D005260:Female; D006213:Hallucinogens / Q000009:adverse effects*; D006801:Humans; D007050:Ibogaine / Q000009:adverse effects; D008297:Male; D012307:Risk Factors; D012651:Self Medication / Q000009:adverse effects / Q000523:psychology; D019966:Substance-Related Disorders / Q000534:rehabilitation*
chemical_list: D006213:Hallucinogens; D007050:Ibogaine