title: Qualitative, semi-quantitative, and quantitative simulation of the osmoregulation system in yeast.
abstract: In this paper we demonstrate how Morven, a computational framework which can perform qualitative, semi-quantitative, and quantitative simulation of dynamical systems using the same model formalism, is applied to study the osmotic stress response pathway in yeast. First the Morven framework itself is briefly introduced in terms of the model formalism employed and output format. We then built a qualitative model for the biophysical process of the osmoregulation in yeast, and a global qualitative-level picture was obtained through qualitative simulation of this model. Furthermore, we constructed a Morven model based on existing quantitative model of the osmoregulation system. This model was then simulated qualitatively, semi-quantitatively, and quantitatively. The obtained simulation results are presented with an analysis. Finally the future development of the Morven framework for modelling the dynamic biological systems is discussed.
authors: School of Natural and Computing Sciences, University of Aberdeen, Aberdeen AB24 3UE, UK. Electronic address: pang.wei@abdn.ac.uk.
authors: Wei
authors: W
authors: Pang
authors: School of Natural and Computing Sciences, University of Aberdeen, Aberdeen AB24 3UE, UK. Electronic address: g.coghill@abdn.ac.uk.
authors: George M
authors: GM
authors: Coghill
mesh_terms: D019295:Computational Biology; D003198:Computer Simulation; D008954:Models, Biological; D064587:Osmoregulation; D036301:Qualitative Research; D012441:Saccharomyces cerevisiae / Q000502:physiology*
keywords: Osmotic stress response; Qualitative simulation; Semi-quantitative simulation