title: [Research progress in the structure and function of dengue virus non-structural 1 protein].
abstract: Dengue virus (DENV) is a re-emerging disease transmitted by the Aedes mosquitoes and has become a major public health problem in southern China. Currently, no antiviral drug or effective vaccine exist to control this disease. The chimeric DENV structural protein vaccine cannot elicit balanced levels of protective immunity to each of the four viral serotypes; therefore, non-structural protein components may be required to construct an effective DENV vaccine. The Dengue virus non-structural 1 (DENV NS1) protein plays a critical role in viral pathogenesis and protective immunity. Therefore, immunity to Dengue 1-4 NS1 subtypes may be crucial for the prevention of severe disease. This review attempts to provide an overview about the structure and function of DENV NS1.
authors: Yue
authors: Y
authors: Chen
authors: Rui-wen
authors: RW
authors: Ren
authors: Jian-wei
authors: JW
authors: Liu
mesh_terms: D000818:Animals; D003715:Dengue / Q000276:immunology / Q000517:prevention & control / Q000821:virology*; D053059:Dengue Vaccines / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D003716:Dengue Virus / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D006801:Humans; D017361:Viral Nonstructural Proteins / Q000737:chemistry* / Q000235:genetics / Q000276:immunology*
chemical_list: D053059:Dengue Vaccines; C082515:NS1 protein, dengue-1 virus; D017361:Viral Nonstructural Proteins