title: Biomarkers of lung injury in cardiothoracic surgery.
abstract: Diagnosis of pulmonary dysfunction is currently almost entirely based on a vast series of physiological changes, but comprehensive research is focused on determining biomarkers for early diagnosis of pulmonary dysfunction. Here we discuss the use of biomarkers of lung injury in cardiothoracic surgery and their ability to detect subtle pulmonary dysfunction in the perioperative period. Degranulation products of neutrophils are often used as biomarker since they have detrimental effects on the pulmonary tissue by themselves. However, these substances are not lung specific. Lung epithelium specific proteins offer more specificity and slowly find their way into clinical studies.
authors: HaemoScan BV, 9723 JC Groningen, Netherlands.
authors: Gerwin Erik
authors: GE
authors: Engels
authors: HaemoScan BV, 9723 JC Groningen, Netherlands ; Department of Cardiothoracic Surgery, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, Netherlands.
authors: Willem
authors: W
authors: van Oeveren
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000097:blood / Q000378:metabolism; D006801:Humans; D055370:Lung Injury / Q000175:diagnosis* / Q000209:etiology; D011663:Pulmonary Surfactants / Q000097:blood / Q000378:metabolism; D019616:Thoracic Surgical Procedures / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D017127:Glycation End Products, Advanced; D011663:Pulmonary Surfactants