title: Host autophagy combating S. aureus: α-toxin will be tolerated.
abstract: Autophagy regulates the degradation of both cellular components and invading intracellular pathogens. In this issue of Cell Host & Microbe, Maurer et al. (2015) reveal that cellular autophagy decreases host sensitivity to Staphylococcus aureus α-toxin via reduced expression of the toxin receptor ADAM10, thus rendering the host tolerant to disease.
authors: Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.
authors: Michael E
authors: ME
authors: Powers
authors: Department of Microbiology, University of Chicago, Chicago, IL 60637, USA; Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA. Electronic address: jbubeckw@peds.bsd.uchicago.edu.
authors: Juliane
authors: J
authors: Bubeck Wardenburg
mesh_terms: D000818:Animals; D001343:Autophagy; D001427:Bacterial Toxins / Q000276:immunology*; D006460:Hemolysin Proteins / Q000276:immunology*; D007108:Immune Tolerance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000276:immunology*
chemical_list: D001427:Bacterial Toxins; D006460:Hemolysin Proteins