title: Oxidative N-heterocyclic carbene catalyzed stereoselective annulation of simple aldehydes and 5-alkenyl thiazolones.
abstract: A highly diastereoselective annulation of simple aldehydes and 5-alkenyl thiazolones, via oxidative NHC catalysis has been developed. This strategy provides facile access to a diverse library of functionalized chiral thiazolo pyrones. Aerobic oxygen can also be applied as a secondary oxidant to avoid the use of stoichiometric organic or inorganic oxidants.
authors: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China. linli@lzu.edu.cn wangrui@lzu.edu.cn.
authors: Li
authors: L
authors: Lin
authors: Yuhong
authors: Y
authors: Yang
authors: Mei
authors: M
authors: Wang
authors: Luhao
authors: L
authors: Lai
authors: Yarong
authors: Y
authors: Guo
authors: Rui
authors: R
authors: Wang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D006571:Heterocyclic Compounds; D011753:Pyrones; D013844:Thiazoles; C030011:carbene; D008697:Methane