title: A noisy tug of war: the battle between transcript production and degradation in the liver.
abstract: Genetically identical cells in culture often exhibit significant variations, or noise, in gene expression, largely due to transcriptional bursting. Halpern et al. (2015) have developed methods to study gene bursting in tissues to find that this transcriptional bursting also occurs in the mammalian liver and may contribute to functional plasticity in hepatocytes.
authors: Department of Bioengineering, University of Utah Biopolymers Research Building, Salt Lake City, UT 84112, USA.
authors: Alec
authors: A
authors: Lam
authors: Department of Bioengineering, University of Utah Biopolymers Research Building, Salt Lake City, UT 84112, USA. Electronic address: tara.deans@utah.edu.
authors: Tara L
authors: TL
authors: Deans
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D022781:Hepatocytes / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger