title: Influence of Sterilization and Storage Period on Elution of Polyvinylpyrrolidone from Wet-Type Polysulfone Membrane Dialyzers.
abstract: The objectives of this study were to investigate the influence of the sterilization and storage period on elution of polyvinylpyrrolidone (PVP) from wet-type polysulfone (PSu) membrane dialyzers. APS-15SA (APS) dialyzers sterilized by gamma-radiation and RENAK PS-1.6 (RENAK) dialyzers sterilized by autoclaving were compared in this study. Each dialyzer was washed with physiological saline and the amount of PVP eluted from the PSu membrane was measured. Then, experimental use of each dialyzer was performed by circulating physiological saline for 4 hours, after which the PVP eluted from the PSu membrane was measured. As the results, the amount of PVP eluted by washing was positively correlated with the storage period for both dialyzers (APS: rs = 0.958; RENAK: rs = 0.952). In the experimental circuit, the amount of PVP eluted from the RENAK dialyzer was positively correlated with the storage period (rs = 0.810), whereas the amount of PVP eluted from the APS dialyzer was negatively correlated with the storage period (rs = -0.833). We found that the amount of PVP eluted from PSu membrane is quite different by the sterilization and storage period of dialyzers.
authors: From the *Department of Biomedical Engineering, Osaka Electro-Communication University, Shijonawate, Japan; †Department of Clinical Engineering, Hattori Hospital, Miki, Japan; and ‡Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan.
authors: Masahiro
authors: M
authors: Miyata
authors: Shuji
authors: S
authors: Konishi
authors: Yoshimasa
authors: Y
authors: Shimamoto
authors: Aki
authors: A
authors: Kamada
authors: Koichi
authors: K
authors: Umimoto
mesh_terms: D006801:Humans; D011205:Povidone; D006435:Renal Dialysis / Q000295:instrumentation*; D013242:Sterilization / Q000379:methods*
chemical_list: D011205:Povidone