title: Drug delivery systems and combination therapy by using vinca alkaloids.
abstract: Developing new methods for chemotherapy drug delivery has become a topic of great concern. Vinca alkaloids are among the most widely used chemotherapy reagents for tumor therapy; however, their side effects are particularly problematic for many medical doctors. To reduce the toxicity and enhance the therapeutic efficiency of vinca alkaloids, many researchers have developed strategies such as using liposome-entrapped drugs, chemical- or peptide-modified drugs, polymeric packaging drugs, and chemotherapy drug combinations. This review mainly focuses on the development of a vinca alkaloid drug delivery system and the combination therapy. Five vinca alkaloids (eg, vincristine, vinblastine, vinorelbine, vindesine, and vinflunine) are reviewed.
authors: Chun-Ting
authors: CT
authors: Lee
authors: Yen-Wei
authors: YW
authors: Huang
authors: Chih-Hui
authors: CH
authors: Yang
authors: School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan. huangks@isu.edu.tw.
authors: Keng-Shiang
authors: KS
authors: Huang
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D014748:Vinca Alkaloids / Q000627:therapeutic use*
chemical_list: D014748:Vinca Alkaloids