title: [In vitro lipid-lowering and fibrinolytic effects of regulatory leucine-containing glyprolines in human blood].
abstract: The lipid-lowering, fibrinolytic, and anticoagulant effects of leucine-containing glyprolines, Pro-Gly-Pro-Leu and Leu-Pro-Gly-Pro, were studied in vitro in the blood of patients with disorders of lipid metabolism. The lipid-lowering impact of glyprolines and their ability to reduce the polymerization and to increase the depolymerization of fibrin in human blood were found. Possible mechanisms of lipolytic action of peptides by means of modulation of the lipid-dependent phospholipase A2 were proposed.
authors: A A
authors: AA
authors: Shabalina
authors: L A
authors: LA
authors: Liapina
authors: D L
authors: DL
authors: Rochev
authors: M V
authors: MV
authors: Kostyreva
authors: M M
authors: MM
authors: Tanashian
authors: Z A
authors: ZA
authors: Suslina
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D009842:Oligopeptides / Q000008:administration & dosage*; D010455:Peptides / Q000008:administration & dosage*; D054467:Phospholipases A2 / Q000097:blood / Q000187:drug effects
chemical_list: D005343:Fibrinolytic Agents; D008055:Lipids; D009842:Oligopeptides; D010455:Peptides; C551701:prolyl-glycyl-prolyl-leucine; D054467:Phospholipases A2