title: A highly selective fluorescent sensor for glucosamine.
abstract: A new fluorescent chemical sensor for glucosamine is reported. The sensor is based on a boronic acid-containing coumarin aldehyde and shows excellent selectivity for glucosamine by forming a boronic ester with the sugar diol as well as an iminium ion with the amine group of glucosamine. The sensor successfully discriminates glucosamine over other similar biomolecules in terms of both fluorescence intensity and binding affinity. This method provides a new concept for the design and synthesis of very selective turn-on optical sensors for selective detection of multi-functional biomolecules.
authors: Department of Chemistry, University of Missouri, Columbia, MO 65211-7600, USA. glasst@missouri.edu.
authors: Tam Minh
authors: TM
authors: Tran
authors: Yuksel
authors: Y
authors: Alan
authors: Timothy Edward
authors: TE
authors: Glass
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D005944:Glucosamine / Q000032:analysis*; D015394:Molecular Structure
chemical_list: D000447:Aldehydes; D001897:Boronic Acids; D003374:Coumarins; D005456:Fluorescent Dyes; C030123:coumarin; D005944:Glucosamine