title: Characterizing brain iron deposition in subcortical ischemic vascular dementia using susceptibility-weighted imaging: An in vivo MR study.
abstract: The aim of this study was to investigate the brain iron accumulation in subcortical ischemic vascular dementia (SIVD) and its correlation with the severity of cognitive impairment. Thirty five patients with SIVD and 35 healthy controls underwent high-resolution susceptibility-weighted imaging. The phase shift value of the bilateral hippocampus (HP), caudate nucleus (CN), globus pallidus (GP), putamen (PU), thalamus (TH), red nucleus (RN), substantia nigra (SN), anterior cingulate cortex (ACC), posterior cingulate (PCC), parietal cortex (PC) and frontal white matter (FWM) were examined and correlated with neuropsychological scores for SIVD patients. They exhibited significant increased phase shift values in the bilateral HP, CN, PU, right GP and left SN (P<0.05). Close correlations were found between the phase shift value of the left HP, right CN and neuropsychological scores. Our results suggest that brain iron deposition may be a biomarker of SIVD and play an important role in the pathophysiological mechanism.
authors: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors: Chen
authors: C
authors: Liu
authors: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors: Chuanming
authors: C
authors: Li
authors: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors: Jun
authors: J
authors: Yang
authors: Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors: Li
authors: L
authors: Gui
authors: McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
authors: Lu
authors: L
authors: Zhao
authors: McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
authors: Alan C
authors: AC
authors: Evans
authors: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China. Electronic address: willyxt@163.com.
authors: Xuntao
authors: X
authors: Yin
authors: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, China. Electronic address: wangjian811@gmail.com.
authors: Jian
authors: J
authors: Wang
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism / Q000523:psychology; D003072:Cognition Disorders / Q000378:metabolism; D015140:Dementia, Vascular / Q000378:metabolism* / Q000523:psychology; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests
chemical_list: D015415:Biomarkers; D007501:Iron
keywords: Cognitive impairment; Iron deposition; Phase changes; SIVD; SWI; Vascular dementia