title: Single oral dose toxicity test of blue honeysuckle concentrate in mice.
abstract: The objective of this study was to obtain single oral dose toxicity information for concentrated and lyophilized powder of blue honeysuckle (Lonicera caerulea L., Caprifoliaceae; BHcL) in female and male ICR mice to aid in the process of developing natural origin medicinal ingredients or foods following proximate analysis and phytochemical profile measurement. The proximate analysis revealed that BHcL had an energy value of 3.80 kcal/g and contained 0.93 g/g of carbohydrate, 0.41 g/g of sugar, 0.02 g/g of protein, and 0.20 mg/g of sodium. BHcL did not contain lipids, including saturated lipids, trans fats, or cholesterols. Further, BHcL contained 4.54% of betaine, 210.63 mg/g of total phenols, 159.30 mg/g of total flavonoids, and 133.57 mg/g of total anthocyanins. Following administration of a single oral BHcL treatment, there were no treatment-related mortalities, changes in body weight (bw) or organ weight, clinical signs, necropsy or histopathological findings up to 2,000 mg/kg bw, the limited dosage for rodents of both sexes. We concluded that BHcL is a practically non-toxic material in toxicity potency.
authors: Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, Korea.
authors: Hyung-Soo
authors: HS
authors: Kim
authors: Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, Korea ; The Medical Research Center for Globalization of Herbal Formulation, Daegu Haany University, Gyeongsan, Korea.
authors: Sang-In
authors: SI
authors: Park
authors: Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, Korea.
authors: Seung-Hoon
authors: SH
authors: Choi
authors: Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, Korea ; The Medical Research Center for Globalization of Herbal Formulation, Daegu Haany University, Gyeongsan, Korea.
authors: Chang-Hyun
authors: CH
authors: Song
authors: Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, Korea ; The Medical Research Center for Globalization of Herbal Formulation, Daegu Haany University, Gyeongsan, Korea.
authors: Soo-Jin
authors: SJ
authors: Park
authors: Department of Natural Medicine Resources, Semyung University, Hecheon, Korea.
authors: Yong-Kook
authors: YK
authors: Shin
authors: Department of Medical History & Literature Group, Korea Institute of Oriental Medicine, Daejeon, Korea.
authors: Chang-Hyun
authors: CH
authors: Han
authors: The Medical Research Center for Globalization of Herbal Formulation, Daegu Haany University, Gyeongsan, Korea.
authors: Young Joon
authors: YJ
authors: Lee
authors: Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, Korea ; The Medical Research Center for Globalization of Herbal Formulation, Daegu Haany University, Gyeongsan, Korea.
authors: Sae-Kwang
authors: SK
authors: Ku
keywords: Blue honeysuckle; Mouse; Phytochemical analysis; Proximate analysis; Single oral dose toxicity