title: Efficacy of a combined in-office/home-use desensitizing system containing 8% arginine and calcium carbonate in reducing dentin hypersensitivity: an 8-week randomized clinical study.
abstract: OBJECTIVE
  To determine the efficacy in reducing dentin hypersensitivity (DHS) of a combined in-office and home-use desensitizing system, each product containing 8% arginine and calcium carbonate (Test), following a dental scaling procedure, compared to the combination of a conventional prophylactic paste and a potassium nitrate dentifrice (Control), in a group of patients with known dentin hypersensitivity.
  
  
  METHODS
  An 8-week clinical study, with 50 subjects, was conducted in Piracicaba, São Paulo, Brazil, using a double-blind/two treatment design. Air blast sensitivity assessments were used to compare the efficacy of the two approaches using both the Schiff scale as well as a Visual Analogue Scale (VAS).
  
  
  RESULTS
  Immediately after prophylaxis, the Test treatment provided significant reduction in DHS when compared to baseline values (VAS = 26.2% and Schiff = 29.1%), while for Control treatment this difference was not statistically significant (VAS = 8.1% and Schiff = 6.6%). The comparison between groups after prophylaxis showed a greater DHS reduction for the Test treatment (P < 0.05). The reductions in DHS after 2, 4 and 8 weeks were significant for both groups, however, when considering Schiff scale, the Test treatment provided greater DHS reduction after 2 weeks (44.5% for Test versus 27.7% for Control) and 4 weeks (55.2% for Test and 40.5% for Control), while after 8 weeks there was no significant difference between groups (71.1% for Test versus 61.1% for Control).
authors: Isabela Lima
authors: IL
authors: França
authors: Enilson Antonio
authors: EA
authors: Sallum
authors: Hugo Felipe
authors: HF
authors: Do Vale
authors: Márcio Zaffalon
authors: MZ
authors: Casati
authors: Antonio Wilson
authors: AW
authors: Sallum
authors: Bernal
authors: B
authors: Stewart
mesh_terms: D000328:Adult; D000368:Aged; D001120:Arginine / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000627:therapeutic use*; D003770:Dental Offices; D012534:Dental Scaling; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000175:diagnosis / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use; D010147:Pain Measurement / Q000379:methods; D010710:Phosphates / Q000627:therapeutic use*; D017680:Potassium Compounds / Q000627:therapeutic use; D011446:Prospective Studies; D012648:Self Care; D014100:Toothpastes / Q000627:therapeutic use*; D016896:Treatment Outcome; D064232:Visual Analog Scale; D055815:Young Adult
chemical_list: D057133:Dentin Desensitizing Agents; D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; D014100:Toothpastes; C585805:pro-argin; D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides; C023844:potassium nitrate