title: Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo.
abstract: The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.
authors: Centre for Neuroregeneration, Centre for Multiple Sclerosis Research, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.
authors: Sigrid
authors: S
authors: Mensch
authors: Centre for Neuroregeneration, Centre for Multiple Sclerosis Research, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.
authors: Marion
authors: M
authors: Baraban
authors: Centre for Neuroregeneration, Centre for Multiple Sclerosis Research, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.
authors: Rafael
authors: R
authors: Almeida
authors: Centre for Neuroregeneration, Centre for Multiple Sclerosis Research, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.
authors: Tim
authors: T
authors: Czopka
authors: Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
authors: Jessica
authors: J
authors: Ausborn
authors: Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
authors: Abdeljabbar
authors: A
authors: El Manira
authors: Centre for Neuroregeneration, Centre for Multiple Sclerosis Research, Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh, UK.
authors: David A
authors: DA
authors: Lyons
mesh_terms: D000818:Animals; D002452:Cell Count; D002678:Chimera; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000187:drug effects; D058787:GABA-A Receptor Antagonists / Q000494:pharmacology; D009186:Myelin Sheath / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009836:Oligodendroglia / Q000166:cytology* / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects; D013572:Synaptic Vesicles / Q000378:metabolism*; D013744:Tetanus Toxin / Q000494:pharmacology; D015027:Zebrafish / Q000196:embryology
chemical_list: D058787:GABA-A Receptor Antagonists; D013744:Tetanus Toxin; D010433:Pentylenetetrazole