title: Anti-Saccharomyces cerevisiae antibody titres correlate well with disease activity in children with Crohn's disease.
abstract: OBJECTIVE
  The role of noninvasive biologic markers for disease activity is very important in children with Crohn's disease. The aim of this study was to assess an association between disease activity and quantitative serum anti-Saccharomyces cerevisiae antibody (ASCA) titres.
  
  
  METHODS
  Anti-Saccharomyces cerevisiae antibody immunoglobulin (Ig) A and immunoglobulin G titres, paediatric Crohn's disease activity index (PCDAI), serum albumin and C-reactive protein (CRP) were repeatedly measured simultaneously in children with Crohn's disease. A possible association between ASCA IgA and IgG titres and changes in PCDAI was examined.
  
  
  RESULTS
  Serial 136 measurements of ASCA IgA and IgG titres were documented in 57 children with Crohn's disease over a mean duration of 3.1 ± 2.1 years. In a univariate linear regression model, there were significant correlations between ASCA IgA titres and PCDAI (p < 0.001), CRP (p <0.01) and low serum albumin (p < 0.001), respectively. Similarly, ASCA IgG titres significantly correlated with PCDAI, CRP and low serum albumin.
  
  
  CONCLUSIONS
  Both ASCA IgA and IgG titres seemed to correlate well with clinical Crohn's disease activity in children. Measuring these antibodies may be considered during routine clinical care for those patients.
authors: Section of Paediatric Gastroenterology, Departments of Paediatrics, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada.|The Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
authors: Wael
authors: W
authors: El-Matary
authors: Section of Paediatric Gastroenterology, Departments of Paediatrics, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada.
authors: Karine
authors: K
authors: Dupuis
authors: Internal Medicine and Pathology, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada.
authors: AbdulRazaq
authors: A
authors: Sokoro
mesh_terms: D000293:Adolescent; D000908:Antibodies, Fungal / Q000097:blood*; D002648:Child; D003424:Crohn Disease / Q000097:blood*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D012189:Retrospective Studies; D012441:Saccharomyces cerevisiae / Q000276:immunology*
chemical_list: D000908:Antibodies, Fungal; D007070:Immunoglobulin A; D007074:Immunoglobulin G
keywords: Anti-Saccharomyces cerevisiae; Antibodies; Colitis; Crohn's disease; Inflammatory bowel disease