title: Why "R" HIT patients predisposed to thrombosis?
abstract: In this issue of Blood, Rollin et al demonstrate that heparin-induced thrombocytopenia and thrombosis (HIT) patients homozygous for arginine (R) at position 131 in the immunoglobulin (Ig)G receptor FcγRIIA have a significantly higher incidence of thrombosis, and show that plasma IgG may play a key role in modulating the thrombotic process.
authors: BLOODCENTER OF WISCONSIN.
authors: Anand
authors: A
authors: Padmanabhan
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D015539:Platelet Activation; D017452:Receptors, IgG / Q000276:immunology*; D013921:Thrombocytopenia / Q000150:complications*; D013927:Thrombosis / Q000209:etiology*
chemical_list: D000925:Anticoagulants; D007074:Immunoglobulin G; D017452:Receptors, IgG; D006493:Heparin