title: Clinical features of AIDS patients with Hodgkin's lymphoma with isolated bone marrow involvement: report of 12 cases at a single institution.
abstract: OBJECTIVE
  To study the main clinical and histopathological features of 12 patients with Hodgkin's lymphoma (HL) diagnosed primarily from bone marrow (BM) involvement.
  
  
  METHODS
  We included 12 acquired immunodeficiency syndrome (AIDS) patients with HL assisted in the F. J. Muñiz Infectious Diseases Hospital since January 2002 to December 2013. The diagnosis of HL with primary BM involvement in patients was confirmed by clinical, histopathological, and immunohistochemical findings.
  
  
  RESULTS
  All patients presented "B" symptoms and pancytopenia. All of them had stage IV neoplasm disease because of BM infiltration. The median of CD4(+) T-cell counts was 114 cells/μL, and mixed cellularity (MC) was the most frequent histopathological subtype of 92% cases.
  
  
  CONCLUSIONS
  When other causes are excluded, BM biopsy should be performed in AIDS patients with "B" symptoms and pancytopenia to evaluate BM infiltration by atypical lymphocytes.
authors: 1 HIV/AIDS Department, F. J. Muñiz Hospital, Buenos Aires 1406, Argentina ; 2 Hematology Unit, 3 Histopathology Laboratory, F. J. Muñiz Hospital, Buenos Aires 1429, Argentina ; 4 National Academy of Medicine, Histopathology Laboratory, Buenos Aires 1425, Argentina ; 5 Sociedad Iberoamericana de Informacion Cientifica, Scientific Coordination, Buenos Aires 1061, Argentina.
authors: Marcelo
authors: M
authors: Corti
authors: 1 HIV/AIDS Department, F. J. Muñiz Hospital, Buenos Aires 1406, Argentina ; 2 Hematology Unit, 3 Histopathology Laboratory, F. J. Muñiz Hospital, Buenos Aires 1429, Argentina ; 4 National Academy of Medicine, Histopathology Laboratory, Buenos Aires 1425, Argentina ; 5 Sociedad Iberoamericana de Informacion Cientifica, Scientific Coordination, Buenos Aires 1061, Argentina.
authors: Maria
authors: M
authors: Villafañe
authors: 1 HIV/AIDS Department, F. J. Muñiz Hospital, Buenos Aires 1406, Argentina ; 2 Hematology Unit, 3 Histopathology Laboratory, F. J. Muñiz Hospital, Buenos Aires 1429, Argentina ; 4 National Academy of Medicine, Histopathology Laboratory, Buenos Aires 1425, Argentina ; 5 Sociedad Iberoamericana de Informacion Cientifica, Scientific Coordination, Buenos Aires 1061, Argentina.
authors: Gonzalo
authors: G
authors: Minue
authors: 1 HIV/AIDS Department, F. J. Muñiz Hospital, Buenos Aires 1406, Argentina ; 2 Hematology Unit, 3 Histopathology Laboratory, F. J. Muñiz Hospital, Buenos Aires 1429, Argentina ; 4 National Academy of Medicine, Histopathology Laboratory, Buenos Aires 1425, Argentina ; 5 Sociedad Iberoamericana de Informacion Cientifica, Scientific Coordination, Buenos Aires 1061, Argentina.
authors: Ana
authors: A
authors: Campitelli
authors: 1 HIV/AIDS Department, F. J. Muñiz Hospital, Buenos Aires 1406, Argentina ; 2 Hematology Unit, 3 Histopathology Laboratory, F. J. Muñiz Hospital, Buenos Aires 1429, Argentina ; 4 National Academy of Medicine, Histopathology Laboratory, Buenos Aires 1425, Argentina ; 5 Sociedad Iberoamericana de Informacion Cientifica, Scientific Coordination, Buenos Aires 1061, Argentina.
authors: Marina
authors: M
authors: Narbaitz
authors: 1 HIV/AIDS Department, F. J. Muñiz Hospital, Buenos Aires 1406, Argentina ; 2 Hematology Unit, 3 Histopathology Laboratory, F. J. Muñiz Hospital, Buenos Aires 1429, Argentina ; 4 National Academy of Medicine, Histopathology Laboratory, Buenos Aires 1425, Argentina ; 5 Sociedad Iberoamericana de Informacion Cientifica, Scientific Coordination, Buenos Aires 1061, Argentina.
authors: Leonardo
authors: L
authors: Gilardi
keywords: Acquired immunodeficiency syndrome (AIDS); Hodgkin’s lymphoma (HL); bone marrow (BM)