title: Beneficial effects of Xuebijing injection on random skin flap survival in rats.
abstract: BACKGROUND
  Improving survival of random skin flaps has important implications of reconstruction, and various kinds of agents have been tested for this purpose. In this study, the effects of Xuebijing (XBJ) injection on random skin flap survival in rats were evaluated.
  
  
  METHODS
  McFarlane flaps were established in 40 rats divided into two groups. XBJ was injected into the test group, and the same concentration of saline was injected into controls. Tissues were stained with hematoxylin and eosin stain and immunohistochemically evaluated, and the survival area of the flaps, superoxide dismutase, and malondialdehyde contents were examined.
  
  
  RESULTS
  Compared with the control group, we found the mean survival area of the flaps in the test group was significantly larger, expression of vascular endothelial growth factor and superoxide dismutase activity increased markedly in the test group, malondialdehyde level in the test group was significantly lower, and the hematoxylin and eosin-stained slices showed that inflammation was clearly inhibited in the test group.
  
  
  CONCLUSIONS
  In summary, XBJ improved survival of random skin flaps.
authors: Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China.
authors: Cao
authors: C
authors: Bin
authors: Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China. Electronic address: lindingsheng@gmail.com.
authors: Lin
authors: L
authors: Dingsheng
authors: Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China.
authors: Cai
authors: C
authors: Leyi
authors: Department of Hand and Plastic Surgery, The Renji College of Wenzhou Medical University, Wenzhou, China.
authors: Lin
authors: L
authors: Bin
authors: Department of Hand and Plastic Surgery, The Renji College of Wenzhou Medical University, Wenzhou, China.
authors: Lin
authors: L
authors: Yuting
authors: Department of Hand and Plastic Surgery, The First Clinical Medical College of Wenzhou Medical University, Wenzhou, China.
authors: Wang
authors: W
authors: Liren
authors: Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, The Second Clinical Medical College of Wenzhou Medical University, Wenzhou, China.
authors: Li
authors: L
authors: Zhijie
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008517:Phytotherapy; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D013524:Surgical Flaps; D014022:Tissue Survival / Q000187:drug effects*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D042461:Vascular Endothelial Growth Factor A; C549376:Xuebijing; C467480:vascular endothelial growth factor A, mouse; D008315:Malondialdehyde; D013482:Superoxide Dismutase
keywords: Inflammation; Ischemia–reperfusion injury; Random flap survival; Xuebijing injection