title: Genetic association analyses of neuregulin 1 gene polymorphism with endopheontype for sociality of Korean autism spectrum disorders family.
abstract: To determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 and rs6994992 SNPs in NRG1 revealed a statistically significant family-based association with three quantitative traits for sociality.
authors: Department of Anatomy and Neuroscience, College of Medicine, Eulji University, Daejeon, Korea.
authors: Hee Jeong
authors: HJ
authors: Yoo
authors: Department of Neuropsychiatry, Seoul National University Bungdang Hospital, Seongnam, Korea.
authors: Ran-Sook
authors: RS
authors: Woo
authors: Department of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors: Soo-Churl
authors: SC
authors: Cho
authors: Department of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors: Boong-Nyun
authors: BN
authors: Kim
authors: Department of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors: Jae-Won
authors: JW
authors: Kim
authors: Department of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors: Min-Sup
authors: MS
authors: Shin
authors: Department of Psychiatry, Chonbuk National University Hospital, Jeonju, Korea.
authors: Tae-Won
authors: TW
authors: Park
authors: Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Korea.
authors: Jung-Woo
authors: JW
authors: Son
authors: Department of Psychiatry, Kyungpook National University Hospital, Daegu, Korea.
authors: Un-Sun
authors: US
authors: Chung
authors: Department of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital, Seoul, Korea.
authors: Subin
authors: S
authors: Park
authors: Department of Preventive Medicine, School of medicine, Eulji University, Daejeon, Korea.
authors: Mira
authors: M
authors: Park
authors: Department of Pharmacology, School of Medicine, Eulji University, 771-77 Gyerhong-ro, Daejeon 301-746, Korea. Electronic address: sakim@eulji.ac.kr.
authors: Soon Ae
authors: SA
authors: Kim
mesh_terms: D044466:Asian People / Q000235:genetics*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000208:ethnology / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005820:Genetic Testing; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D020890:Neuregulin-1 / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*
chemical_list: D020890:Neuregulin-1
keywords: Autism spectrum disorder; Family-based association study; Neuregulin 1