title: Inflammatory bowel disease and the elderly: a review.
abstract: Inflammatory bowel disease among the elderly is common, with growing incident and prevalence rates. Compared with younger IBD patients, genetics contribute less to the pathogenesis of older-onset IBD, with dysbiosis and dysregulation of the immune system playing a more significant role. Diagnosis may be difficult in older individuals, as multiple other common diseases can mimic IBD in this population. The clinical manifestations in older-onset IBD are distinct, and patients tend to have less of a disease trajectory. Despite multiple effective medical and surgical treatment strategies for adults with Crohn's disease and ulcerative colitis, efficacy studies typically have excluded older subjects. A rapidly ageing population and increasing rates of Crohn's and ulcerative colitis make the paucity of data in older adults with IBD an increasingly important clinical issue.
authors: Department of Medicine, University of Arisona College of Medicine, Tucson, AZ, USA staleban@yahoo.com.
authors: Sasha
authors: S
authors: Taleban
authors: Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors: Jean-Frederic
authors: JF
authors: Colombel
authors: Department of Medicine, University of Arisona College of Medicine, Tucson, AZ, USA Arisona Center on Aging, University of Arisona, Tucson, AZ, USA.
authors: M Jane
authors: MJ
authors: Mohler
authors: Department of Medicine, University of Arisona College of Medicine, Tucson, AZ, USA Arisona Center on Aging, University of Arisona, Tucson, AZ, USA.
authors: Mindy J
authors: MJ
authors: Fain
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D011159:Population Surveillance; D013256:Steroids / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014611:Vaccination
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007155:Immunologic Factors; D013256:Steroids; D014409:Tumor Necrosis Factor-alpha; D019804:Mesalamine
keywords: Elderly; inflammatory bowel disease; older