title: Expressions of survivin, P16(INK4a), COX-2, and Ki-67 in cervical cancer progression reveal the potential clinical application.
abstract: OBJECTIVE
  To explore the significance of survivin, P16(INK4a), COX-2, and Ki-67 expressions for prediction of cervical cancer progression.
  
  
  METHODS
  A retrospective study was performed in 129 cases including 24 squamous carcinoma of the cervix (SCC), 70 cervical intraepithelial neoplasias (CIN), 15 cervical condyloma acuminatum (CCA), ten chronic cervicitis (CC), and ten normal cervix (NC). Protein expressions were evaluated using immunohistochemistry.
  
  
  RESULTS
  Survivin, P16(INK4a); COX-2, and Ki-67 were highly expressed in SCC and CIN compared with others. Their expression rates were gradually increased in CIN I, CIN II, CIN III, and SCC groups, showing 72.00%, 88.00%, 90.00%, and 95.83% for P16(INK4a), 68.00%, 84.00%, 95.00% and 100.00% for COX-2, 76.00%, 96.00%, 100.00%, and 100.00 for Ki-67, respectively. There were significant correlations between survivin and P16(INK4a), COX-2, Ki-67, as well as P16(INK4a) and Ki-67.
  
  
  CONCLUSIONS
  Survivin, P16(INK4a), COX-2 and Ki-67 play critical roles for development and progression of cervical cancer.
authors: W Q
authors: WQ
authors: Zhou
authors: Q Y
authors: QY
authors: Sheng
authors: Y H
authors: YH
authors: Sheng
authors: W J
authors: WJ
authors: Hou
authors: G X
authors: GX
authors: Xu
authors: Y M
authors: YM
authors: Wu
authors: H
authors: H
authors: Lu
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D002584:Cervix Uteri / Q000737:chemistry; D002908:Chronic Disease; D003218:Condylomata Acuminata / Q000378:metabolism; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis; D051546:Cyclooxygenase 2 / Q000032:analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D000077022:Survivin; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000473:pathology; D002575:Uterine Cervicitis / Q000378:metabolism; D002578:Uterine Cervical Dysplasia / Q000737:chemistry* / Q000473:pathology
chemical_list: C107489:BIRC5 protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D000077022:Survivin; D051546:Cyclooxygenase 2