title: Inhibited fragmentation of mAbs in buffered ionic liquids.
abstract: We thoroughly investigated the biological, structural and chemical stability of epidermal growth factor receptor monoclonal antibody (EGFR mAb) using choline-based buffered ionic liquids (BILs). The results demonstrated substantially enhanced stabilities in our BILs, indicating their huge promise as real-world green biological buffers for antibody storage and transportation.
authors: Department of Chemical Engineering, Monash University, Clayton 3800, VIC, Australia. wenlong.cheng@monash.edu.
authors: Romiza R
authors: RR
authors: Mazid
authors: R
authors: R
authors: Vijayaraghavan
authors: Douglas R
authors: DR
authors: MacFarlane
authors: Christina
authors: C
authors: Cortez-Jugo
authors: Wenlong
authors: W
authors: Cheng
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry* / Q000378:metabolism; D002021:Buffers; D002794:Choline / Q000737:chemistry* / Q000378:metabolism; D066246:ErbB Receptors / Q000737:chemistry* / Q000378:metabolism; D052578:Ionic Liquids / Q000737:chemistry* / Q000378:metabolism; D010447:Peptide Hydrolases / Q000737:chemistry / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D002021:Buffers; D052578:Ionic Liquids; D066246:ErbB Receptors; D010447:Peptide Hydrolases; D002794:Choline