title: Cisplatin binding to human serum albumin: a structural study.
abstract: The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.
authors: Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, I-80126, Napoli, Italy. antonello.merlino@unina.it.
authors: Giarita
authors: G
authors: Ferraro
authors: Lara
authors: L
authors: Massai
authors: Luigi
authors: L
authors: Messori
authors: Antonello
authors: A
authors: Merlino
mesh_terms: D001665:Binding Sites; D002945:Cisplatin / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006801:Humans; D008968:Molecular Conformation; D012709:Serum Albumin / Q000737:chemistry*
chemical_list: D012709:Serum Albumin; D002945:Cisplatin