title: Comparison of the efficacy of liraglutide with pioglitazone on dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycaemia in albino rats.
abstract: OBJECTIVE
  To evaluate the efficacy of liraglutide with pioglitazone for prevention of dexamethasone induced hepatic steatosis, dyslipidemia and hyperglycemia in Albino rats.
  
  
  METHODS
  There were four groups of six rats each. First group received dexamethasone alone in a dose of 8 mg/kg intraperitoneally for 6 days to induce metabolic changes and considered as dexamethasone control. Second group received liraglutide 1.8 mg/kg subcutaneously 6 days before dexamethasone and 6 days during dexamethasone administration. Third group received pioglitazone 45 mg/kg orally 6 days before dexamethasone and 6 days during dexamethasone administration. Fourth group did not receive any medication and was considered as normal control. Fasting blood sugar, lipid profile, blood sugar 2 h after glucose load were measured. Liver weight, liver volume, and histopathological analysis were done.
  
  
  RESULTS
  Dexamethasone caused hepatomegaly, dyslipidemia, and hyperglycemia. Both pioglitazone and liraglutide significantly reduced hepatomegaly, dyslipidemia and hyperglycemia (P < 0.01). Reduction of blood sugar levels after glucose load was significant with pioglitazone when compared with liraglutide (P < 0.01).
  
  
  CONCLUSIONS
  Liraglutide has comparable efficacy to pioglitazone in prevention of dexamethasone induced hepatomegaly, dyslipidemia and fasting hyperglycemia.
authors: Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: K
authors: K
authors: Vinodraj
authors: Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: I M
authors: IM
authors: Nagendra Nayak
authors: Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: J Vikram
authors: JV
authors: Rao
authors: Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: Paul
authors: P
authors: Mathai
authors: Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: N
authors: N
authors: Chandralekha
authors: Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: B
authors: B
authors: Nitasha
authors: Department of Pharmacology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: D
authors: D
authors: Rajesh
authors: Department of Community Medicine, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India.
authors: T K
authors: TK
authors: Chethan
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects*; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D005234:Fatty Liver / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D050356:Lipid Metabolism / Q000187:drug effects; D008055:Lipids / Q000097:blood; D000069450:Liraglutide / Q000008:administration & dosage / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D000077205:Pioglitazone; D017208:Rats, Wistar; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D008055:Lipids; D045162:Thiazolidinediones; D003907:Dexamethasone; D000069450:Liraglutide; D000077205:Pioglitazone
keywords: Dexamethasone; hepatomegaly; hyperglycemia; liraglutide; pioglitazone; prevention