title: Relationship of Bone Metabolism Biomarkers and Periodontal Disease: The Osteoporotic Fractures in Men (MrOS) Study.
abstract: BACKGROUND
  Periodontitis is an inflammatory disease of tooth-supporting tissue leading to bone destruction and tooth loss. Periodontitis affects almost 50% of adults greater than 30 years of age.
  
  
  OBJECTIVE
  This study evaluated the association between biomarkers linked to bone formation and resorption with the occurrence and progression of periodontal disease in older men (≥ 65 y).
  
  
  METHODS
  The Osteoporotic Fractures in Men (MrOS) study is a prospective, observational study among men 65 years of age and older.
  
  
  METHODS
  This ancillary study, Oral and Skeletal Bone Loss in Older Men, was conducted at two of the six MrOS study sites (Birmingham, AL and Portland, OR).
  
  
  METHODS
  Patients underwent medical and dental evaluation. Diagnoses of periodontitis were based on clinical attachment loss, pocket depth, calculus, plaque, and bleeding on a random half-mouth. Bone metabolism biomarkers included serum levels of calcium, phosphate (Pi), alkaline phosphatase, albumin, carboxy-terminal collagen crosslinks (CTX), N-terminal propeptides of type I procollagen, isoform 5b of tartrate-resistant acid phosphatase, and urine alpha- carboxy-terminal collagen crosslinks (alpha-CTX) and beta-CTX and serum levels of calciotropic hormones vitamin D (25(OH)D) and PTH.
  
  
  METHODS
  The aim of this study is to correlate bone metabolism biomarkers with prevalence and progression of periodontal disease in older men.
  
  
  RESULTS
  Patients with more severe periodontitis had significantly higher levels of PTH (P trend = .0004), whereas 25(OH)D was lower (P trend = .001). In a subset of men reevaluated at a second dental visit, improvement of periodontitis was associated with lower alpha-CTX, beta-CTX, and CTX levels at baseline after adjusting for age, site, and body mass index.
  
  
  CONCLUSIONS
  This study suggests that a distinct set of biomarkers of bone metabolism are associated with more severe periodontal disease (PTH, 25(OH)D) and periodontal progression (alpha-CTX, beta-CTX, and CTX) over time.
authors: Ulrike
authors: U
authors: Schulze-Späte
authors: Ryan
authors: R
authors: Turner
authors: Ying
authors: Y
authors: Wang
authors: Raylien
authors: R
authors: Chao
authors: P Christian
authors: PC
authors: Schulze
authors: Kathy
authors: K
authors: Phipps
authors: Eric
authors: E
authors: Orwoll
authors: Thuy-Tien
authors: TT
authors: Dam
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D001851:Bone Diseases, Metabolic / Q000097:blood / Q000453:epidemiology; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I / Q000097:blood; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D058866:Osteoporotic Fractures / Q000097:blood* / Q000453:epidemiology; D010455:Peptides / Q000097:blood; D010510:Periodontal Diseases / Q000097:blood* / Q000453:epidemiology; D010518:Periodontitis / Q000097:blood / Q000453:epidemiology; D000071681:Tartrate-Resistant Acid Phosphatase; D014807:Vitamin D / Q000097:blood
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D007527:Isoenzymes; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D014807:Vitamin D; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase