title: CD146: the unveiling of a pro-angiogenic netrin receptor.
abstract: Netrin-1, a classic neuronal guidance cue, can promote angiogenesis under certain developmental and pathological conditions, but key receptors on vascular endothelium have remained elusive. A recent study published in Cell Research by Tu et al. reveals that CD146, an endothelial receptor of the immunoglobulin superfamily, binds netrin-1 with high affinity and may play an important role in regulating angiogenesis.
authors: Tumor Angiogenesis Section, Mouse Cancer Genetics Program, National Cancer Institute (NCI), NIH, Frederick, MD 21702, USA.
authors: Brad
authors: B
authors: St Croix
mesh_terms: D000818:Animals; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009414:Nerve Growth Factors / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D009414:Nerve Growth Factors; D025521:Tumor Suppressor Proteins