title: MANAGEMENT OF ENDOCRINE DISEASE: Management of pregnant patients with Cushing's syndrome.
abstract: Progress in the diagnosis and treatment of endocrine diseases has turned pregnancy into a possibility for women with such medical disorders, including Cushing's syndrome (CS). Nevertheless, despite its rarity, pregnancy in patients with CS can be troublesome because of the risk of maternal-fetal complications. Therefore, hypercortisolism, if present, should be surgically or medically controlled in most cases. Moreover, changes in the hypothalamic-pituitary-adrenal axis during normal pregnancy may mislead the diagnosis of CS during this period, because many laboratory assessments suggestive of CS may be present in normal pregnancy, with clinical features mimicking those seen in patients with CS. The aim of the present review is to update the diagnostic approach to this medical condition, mainly for pregnant women without previous diagnosis of CS, and to describe the therapeutic strategies for CS during pregnancy in order to minimize complications for both mother and fetus.
authors: Neuroendocrine UnitAdrenal UnitDivision of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo Medical School, Avenida Enéas de Carvalho Aguiar, 155 8° andar Bloco 03São Paulo, São Paulo 05403-000, Brazil mdbronstein@uol.com.br.
authors: M D
authors: MD
authors: Bronstein
authors: Neuroendocrine UnitAdrenal UnitDivision of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo Medical School, Avenida Enéas de Carvalho Aguiar, 155 8° andar Bloco 03São Paulo, São Paulo 05403-000, Brazil.
authors: M C
authors: MC
authors: Machado
authors: Neuroendocrine UnitAdrenal UnitDivision of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo Medical School, Avenida Enéas de Carvalho Aguiar, 155 8° andar Bloco 03São Paulo, São Paulo 05403-000, Brazil Neuroendocrine UnitAdrenal UnitDivision of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo Medical School, Avenida Enéas de Carvalho Aguiar, 155 8° andar Bloco 03São Paulo, São Paulo 05403-000, Brazil.
authors: M C B V
authors: MC
authors: Fragoso
mesh_terms: D003480:Cushing Syndrome / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy*; D019468:Disease Management; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy*