title: [Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis].
abstract: DNA methylation is associated with a large number of biological processes and mainly concerns the cytosine methylation at position 5 (5-mC). An active demethylation mechanism was highlighted in 2009 following the discovery that TET proteins were enzymes implicated in the hydroxylation of 5-mC to 5-hydroxymethylcytosine. Simultaneously, other studies showed frequent acquired TET2 mutations in hematological malignancies and have depicted their role in their pathogenesis. An entire field of research has developed rapidly showing that these proteins are involved in many biological processes.
authors: Inserm 1170, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805 Villejuif, France - Institut Gustave Roussy, Villejuif, France - Université Paris XI, Orsay, France - Laboratoire d'hématologie moléculaire et cellulaire (S. Abbes), Institut Pasteur de Tunis, Belvédère, Tunisie.
authors: Emna
authors: E
authors: Mahfoudhi
authors: Inserm 1170, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805 Villejuif, France - Institut Gustave Roussy, Villejuif, France - Université Paris XI, Orsay, France.
authors: Lise
authors: L
authors: Secardin
authors: Inserm 1170, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805 Villejuif, France - Institut Gustave Roussy, Villejuif, France - Université Paris XI, Orsay, France.
authors: Laurianne
authors: L
authors: Scourzic
authors: Inserm 1170, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805 Villejuif, France - Institut Gustave Roussy, Villejuif, France - Université Paris XI, Orsay, France.
authors: Olivier
authors: O
authors: Bernard
authors: Inserm 1170, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805 Villejuif, France - Institut Gustave Roussy, Villejuif, France - Université Paris XI, Orsay, France.
authors: William
authors: W
authors: Vainchenker
authors: Inserm 1170, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805 Villejuif, France - Institut Gustave Roussy, Villejuif, France - Université Paris XI, Orsay, France.
authors: Isabelle
authors: I
authors: Plo
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D049308:Dioxygenases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D047108:Embryonic Development / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D006899:Mixed Function Oxygenases; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D006899:Mixed Function Oxygenases; C462539:TET1 protein, human; C578792:TET3 protein, human; D049308:Dioxygenases; C541081:TET2 protein, human