title: [SNP microarray analysis of retention abortion chorionic villus].
abstract: OBJECTIVE
  To compare villus cell culture and karyotype analysis with single nucleotide polymorphism (SNP) microarray technology for the detection of chorionic villus chromosome in patients with retention of abortion.
  
  
  METHODS
  Forty cases were analyzed with the two methods.
  
  
  RESULTS
  Chorionic villus culturing was successful in 29 cases, among which 10 were found to have an abnormal karyotypes. For the SNP microarray analysis, all 40 cases were successful, among which 16 were shown to have an abnormal molecular karyotype.
  
  
  CONCLUSIONS
  SNP microarray technology is highly accurate and specific, which is particularly suitable for the detection of chromosomal deletions or duplications, uniparental disomy, low-percentage mosaicism and other chromosomal abnormalities. It has provided an effective supplement to the conventional chorionic villus culture and karyotype analysis.
authors: Graduate School, Tianjin Medical University, Tianjin 300070, P.R. China. prettylucy@126.com.
authors: Linghong
authors: L
authors: Wang
authors: Chenchun
authors: C
authors: Ren
authors: Ying
authors: Y
authors: Tian
authors: Wenjing
authors: W
authors: Wang
authors: Chenjin
authors: C
authors: Wang
authors: Shuqin
authors: S
authors: Chen
authors: Yuehong
authors: Y
authors: Liang
authors: Haixia
authors: H
authors: Zhang
authors: Yuexiang
authors: Y
authors: Zhang
authors: Weiwei
authors: W
authors: Yang
mesh_terms: D000030:Abortion, Missed / Q000235:genetics*; D000328:Adult; D002824:Chorionic Villi / Q000737:chemistry*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000235:genetics