title: Cerebral microvascular pericytes and neurogliovascular signaling in health and disease.
abstract: Increases in neuronal activity cause an enhanced blood flow to the active brain area. This neurovascular coupling is regulated by multiple mechanisms: Adenosine and lactate produced as metabolic end-products couple activity with flow by inducing vasodilation. As a specific mechanism to the brain, synaptic activity-induced Ca(2+) increases in astrocytes, interneurons and neurons translate neuronal activity to vasoactive signals such as arachidonic acid metabolites and NO. K(+) released onto smooth muscle cells through Ca(2+)-activated K(+) channels on end-feet can also induce vasodilation during neuronal activity. An intense communication between the endothelia, pericytes and astrocytes is required for development and functioning of the neurovascular unit as well as the BBB. The ratio of pericytes to endothelial cells is higher in the cerebral microcirculation than other tissues. Pericytes play a role in distribution of microvascular blood flow in response to the local demand as a final regulatory step after arterioles, which feed a larger cohort of cells. Pericyte-endothelial communication is essential for vasculogenesis. Pericyte also take part in leukocyte infiltration and immune responses. The microvascular injury induced by ischemia/reperfusion plays a critical role in tissue survival after recanalization by inducing sustained pericyte contraction and microcirculatory clogging (no-reflow) and by disrupting BBB integrity. Suppression of oxidative/nitrative stress or sustained adenosine delivery during re-opening of an occluded artery improves the outcome of recanalization by promoting microcirculatory reflow. Pericyte dysfunction in retinal microvessels is the main cause of diabetic retinopathy. Recent findings suggest that the age-related microvascular dysfunction may initiate the neurodegenerative changes seen Alzheimer׳s dementia. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.
authors: Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Institute of Neurological Sciences and Psychiatry, Hacettepe University, 06100 Sıhhıye, Ankara, Turkey; Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard University, Boston, USA. Electronic address: tdalkara@hacettepe.edu.tr.
authors: Turgay
authors: T
authors: Dalkara
authors: Institute of Neurological Sciences and Psychiatry, Hacettepe University, 06100 Sıhhıye, Ankara, Turkey.
authors: Luis
authors: L
authors: Alarcon-Martinez
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000502:physiology* / Q000503:physiopathology*; D006801:Humans; D055806:Microvessels / Q000502:physiology* / Q000503:physiopathology*; D009457:Neuroglia / Q000502:physiology*; D000069336:Neurovascular Coupling / Q000502:physiology; D020286:Pericytes / Q000502:physiology*
keywords: Angiogenesis; Dementia; Inflammation; Neurovascular coupling; Neurovascular unit; Pericyte; Recanalization; Retinopathy