title: Diagnoses in Pediatric Patients With Magnetic Resonance Imaging (MRI) Lesions Suspicious for Demyelination.
abstract: Magnetic resonance imaging (MRI) studies of the brain in pediatric patients frequently show abnormal white matter lesions, which may be concerning for demyelinating disease. This study aimed to determine the proportion of pediatric patients who have MRI lesions concerning for demyelinating disease at presentation and ultimately are diagnosed with a primary central nervous system demyelinating disease. A retrospective chart review was performed on MRI reports of patients who underwent imaging evaluation at a single tertiary pediatric hospital. Of 299 patients identified, 192 presented with acute neurologic complaints. In this group, ≥ 5 discrete lesions, African American race, and having brain stem, thalamic, cerebellar, or optic nerve lesions was associated with the patient being diagnosed with a disease that required further treatment. The other 107 patients underwent MRI for other indications. Among these subjects, having lesions within the corpus callosum or cerebellum was associated with being diagnosed with a disease requiring further treatment.
authors: Department of Child Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA Michael.Sweeney@cchmc.org.
authors: Michael L
authors: ML
authors: Sweeney
authors: Department of Radiology, Texas Children's Hospital, Houston, TX, USA.
authors: Marcia
authors: M
authors: Kukreja
authors: Department of Child Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA Division of Biostatistics & Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors: Paul S
authors: PS
authors: Horn
authors: Department of Child Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors: Shannon M
authors: SM
authors: Standridge
mesh_terms: D001921:Brain / Q000473:pathology*; D002648:Child; D005260:Female; D006776:Hospitals, Pediatric; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D019636:Neurodegenerative Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology*; D012189:Retrospective Studies; D062606:Tertiary Care Centers
keywords: MRI; demyelinating disease; pediatric