title: Influence of surgical technique in the peritoneal carcinomatosis surgical wound implant: experimental model in mice.
abstract: BACKGROUND
  The number of malignancies increased alarmingly. Surgery constitutes one of the most efficient therapeutic modalities for the treatment of solid tumors. The neoplastic implant in surgical wound is a complication whose percentage of occurrence reported in the literature is variable, but sets with high morbidity and therapeutic difficulties. Protecting the wound is one of the recommended principles of oncologic surgery.
  
  
  OBJECTIVE
  To evaluate the influence of wound protection in the development of tumor implantation.
  
  
  METHODS
  Sarcoma 180 tumor cells were used, with intraperitoneal inoculation in Swiss mice. After the establishment of neoplastic ascites, animals were randomized into two groups of 10, each group consisting of five males and five females. In both groups, laparotomy and manipulation of intra-abdominal organs was performed. In a group laparotomy was performed using the protection of the abdominal wound and the other group without it. On the 9th postoperative day macroscopic evaluation of the operative scar was performed, which was later removed for microscopic evaluation.
  
  
  RESULTS
  There was microscopic infiltration of tumor cells in the wound of all animals. However, the group that held the protection, infiltration was less intense when compared to the group without it. The infiltration was also more severe in females than in males of the same group.
  
  
  CONCLUSIONS
  Tumor infiltration into the wound was more intense in the group in which the protection of the surgical site was not performed, and in females when compared to males of the same group.
authors: Pontifícia Universidade Católica, Goiânia, Goiás, Brazil.
authors: Roberto Maranhão
authors: RM
authors: Rosa
authors: Pontifícia Universidade Católica, Goiânia, Goiás, Brazil.
authors: Rafael Coelho
authors: RC
authors: Caiado
authors: Pontifícia Universidade Católica, Goiânia, Goiás, Brazil.
authors: Paulo Roberto de Melo
authors: PR
authors: Reis
authors: Pontifícia Universidade Católica, Goiânia, Goiás, Brazil.
authors: Elisângela de Paula Silveira
authors: Ede P
authors: Lacerda
authors: Pontifícia Universidade Católica, Goiânia, Goiás, Brazil.
authors: Denis Masashi
authors: DM
authors: Sugita
authors: Pontifícia Universidade Católica, Goiânia, Goiás, Brazil.
authors: Fátima
authors: F
authors: Mrué
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000517:prevention & control / Q000556:secondary* / Q000601:surgery*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000473:pathology* / Q000601:surgery*; D011897:Random Allocation; D013514:Surgical Procedures, Operative / Q000009:adverse effects* / Q000379:methods*