title: Synthesis of selenazolopyridine derivatives with capability to induce apoptosis in human breast carcinoma MCF-7 cells through scavenge of intracellular ROS.
abstract: A series of selenazolopyridine derivatives have been synthesized and characterized by X-ray diffraction, high resolution NMR and Mass spectrum. The in vitro anticancer activities of the synthetic compounds were screened against a panel of human cancer cell lines, human breast carcinoma MCF-7 cells, human liver carcinoma HepG2 cells and L02 normal cell line by MTT assay. By analyzing the structure-activity relationship among the synthetic compounds, it was found that 2-(phenylamino) selenazolo [5,4-b] pyridine, (PSeD, 7) had higher growth inhibitory effect on MCF-7 cells. The intracellular mechanism of cell death was evaluated by flow cytometric analysis and ROS assay, which revealed that PSeD could induce MCF-7 cells apoptosis by scavenging intracellular ROS. Taken together, we regard PSeD as an antioxidant which could inhibit cancer cell growth through induction of apoptosis.
authors: Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
authors: Meiyun
authors: M
authors: Zhou
authors: Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
authors: Shengbin
authors: S
authors: Ji
authors: Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
authors: Zhaojun
authors: Z
authors: Wu
authors: Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
authors: Yiqun
authors: Y
authors: Li
authors: Department of Chemistry, Jinan University, Guangzhou 510632, PR China. Electronic address: tzhwj@jnu.edu.cn.
authors: Wenjie
authors: W
authors: Zheng
authors: Department of Food Science and Engineering, Jinan University, Guangzhou 510632, PR China.
authors: Hua
authors: H
authors: Zhou
authors: Department of Chemistry, Jinan University, Guangzhou 510632, PR China. Electronic address: tchentf@jnu.edu.cn.
authors: Tianfeng
authors: T
authors: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D008958:Models, Molecular; D015394:Molecular Structure; D016566:Organoselenium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: C000604900:2-(phenylamino)selenazolo(5,4-b)pyridine; D000970:Antineoplastic Agents; D016166:Free Radical Scavengers; D016566:Organoselenium Compounds; D011725:Pyridines; D017382:Reactive Oxygen Species
keywords: Anticancer activity; Cell apoptosis; ROS; Selenazolopyridine derivatives