title: Design and synthesis of fluorinated dendrimers for sensitive (19)F MRI.
abstract: To achieve high sensitivity for (19)F MRI, a class of novel dendritic molecules with multiple pseudosymmetrical fluorines was designed and efficiently synthesized. Through iterative bromination and Williamson ether synthesis under mild conditions, a fluorinated dendrimer with 540 pseudosymmetrical fluorines was conveniently prepared without performing the group protection in a convergent way. The dendrimer is characterized by a strong (19)F NMR peak and short relaxation times. Eventually, an appreciably enhanced (19)F MRI at an extremely low concentration (18.5 μM) was achieved, which demonstrated the potential utility of such dendritic molecules in highly sensitive (19)F MRI.
authors: †Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
authors: Weijiang
authors: W
authors: Yu
authors: ‡Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.
authors: Yuqi
authors: Y
authors: Yang
authors: §Hunan Provincial Education Department, Approval no. 2014-405, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
authors: Shaowei
authors: S
authors: Bo
authors: †Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
authors: Yu
authors: Y
authors: Li
authors: ‡Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.
authors: Shizhen
authors: S
authors: Chen
authors: †Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.
authors: Zhigang
authors: Z
authors: Yang
authors: §Hunan Provincial Education Department, Approval no. 2014-405, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
authors: Xing
authors: X
authors: Zheng
authors: †Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.|§Hunan Provincial Education Department, Approval no. 2014-405, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China.
authors: Zhong-Xing
authors: ZX
authors: Jiang
authors: ‡Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory for Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China.
authors: Xin
authors: X
authors: Zhou
mesh_terms: D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry; D066235:Fluorine-19 Magnetic Resonance Imaging; D005466:Fluorocarbons / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D050091:Dendrimers; D005466:Fluorocarbons