title: Compensatory recombination phenomena of neurological functions in central dysphagia patients.
abstract: We speculate that cortical reactions evoked by swallowing activity may be abnormal in patients with central infarction with dysphagia. The present study aimed to detect functional imaging features of cerebral cortex in central dysphagia patients by using blood oxygen level-dependent functional magnetic resonance imaging techniques. The results showed that when normal controls swallowed, primary motor cortex (BA4), insula (BA13), premotor cortex (BA6/8), supramarginal gyrus (BA40), and anterior cingulate cortex (BA24/32) were activated, and that the size of the activated areas were larger in the left hemisphere compared with the right. In recurrent cerebral infarction patients with central dysphagia, BA4, BA13, BA40 and BA6/8 areas were activated, while the degree of activation in BA24/32 was decreased. Additionally, more areas were activated, including posterior cingulate cortex (BA23/31), visual association cortex (BA18/19), primary auditory cortex (BA41) and parahippocampal cortex (BA36). Somatosensory association cortex (BA7) and left cerebellum in patients with recurrent cerebral infarction with central dysphagia were also activated. Experimental findings suggest that the cerebral cortex has obvious hemisphere lateralization in response to swallowing, and patients with recurrent cerebral infarction with central dysphagia show compensatory recombination phenomena of neurological functions. In rehabilitative treatment, using the favorite food of patients can stimulate swallowing through visual, auditory, and other nerve conduction pathways, thus promoting compensatory recombination of the central cortex functions.
authors: Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors: Xiao-Dong
authors: XD
authors: Yuan
authors: Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors: Li-Fu
authors: LF
authors: Zhou
authors: Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors: Shu-Juan
authors: SJ
authors: Wang
authors: Department of MRI Room, Affiliated Kailuan General Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors: Yan-Sheng
authors: YS
authors: Zhao
authors: Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors: Xiao-Jie
authors: XJ
authors: Wang
authors: Department of Neurology, Affiliated Kailuan General Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors: Li-Li
authors: LL
authors: Zhang
authors: Department of MRI Room, Affiliated Kailuan General Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors: Shou-Hong
authors: SH
authors: Wang
authors: Department of MRI Room, Affiliated Kailuan General Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors: Ya-Jie
authors: YJ
authors: Zhang
authors: Department of MRI Room, Affiliated Kailuan General Hospital of Hebei United University, Tangshan, Hebei Province, China.
authors: Li
authors: L
authors: Chen
keywords: blood oxygen level-dependent functional magnetic resonance imaging; cerebral cortex; cerebral ischemia; dysphagia; function restructuring; nerve regeneration; neural regeneration