title: [Preparation technology optimization of xiaozhong cataplasm by central composite design-response surface method and preliminary clinical effect evaluation].
abstract: OBJECTIVE
  To optimize the preparation technology of Xiaozhong Cataplasm and to evaluate its preliminary clinical effect.
  
  
  METHODS
  The viscosity, residue and appearance were selected as evaluation indexes. The central composite design-response surface methodology was applied to optimize the amounts of Skeleton material, tackifier and crosslinking agent. Clinical effect of Xiaozhong Cataplasm was observed.
  
  
  RESULTS
  The optimal formulation was HQ841: PVP k120: PVPP: aluminium glycinate: water: glycerin: ethanol = 4:3:2:0.15: 60:25:10. The effective rate of the cataplasm was 97.22% and 91.67% had marked effect.
  
  
  CONCLUSIONS
  Prepared by the optimal preparation technology, the cataplasm has the moderate viscosity and little residue with good clinical effect.
authors: Ya-jun
authors: YJ
authors: Shi
authors: Pu-wei
authors: PW
authors: Yuan
authors: Hui
authors: H
authors: Wang
authors: Xiao-fei
authors: XF
authors: Zhang
authors: Dong-yan
authors: DY
authors: Guo
mesh_terms: D002626:Chemistry, Pharmaceutical; D004365:Drugs, Chinese Herbal; D005990:Glycerol; D014783:Viscosity
chemical_list: D004365:Drugs, Chinese Herbal; D005990:Glycerol