title: The cutaneous vasoconstrictor response in lower extremities during whole-body and local skin cooling in young women with a cold constitution.
abstract: To clarify the characteristics of the thermal control of skin blood flow (SkBF) in individuals with a cold constitution, we examined the cutaneous vasoconstrictor responses in the calf and dorsal foot during whole-body and local skin cooling in young women complaining of chilliness (C group) and young women not suffering from it (N group). During whole-body skin cooling, the vasoconstrictor sensitivity in the dorsal foot, but not in the calf, was greater in the C group than in the N group. The C group also showed greater vasoconstrictor responses in the dorsal foot, but not in the calf, during local skin cooling and the iontophoretic application of norepinephrine. These findings suggest that the C group possesses a specific SkBF controlling system that is characterized by higher adrenergic sensitivity for greater cutaneous vasoconstriction in the distal portion of the lower extremities during cold exposure.
authors: Exercise Physiology Laboratory, Faculty of Nursing and Nutrition, Yamaguchi Prefectural University, 6-2-1 Sakurabatake, Yamaguchi, 753-0021, Japan, fsone@n.ypu.jp.
authors: Fumio
authors: F
authors: Yamazaki
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000367:Age Factors; D001783:Blood Flow Velocity; D001833:Body Temperature Regulation; D003080:Cold Temperature; D005260:Female; D006801:Humans; D007478:Iontophoresis; D035002:Lower Extremity; D009638:Norepinephrine / Q000008:administration & dosage; D010641:Phenotype; D012039:Regional Blood Flow; D012737:Sex Factors; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature; D013997:Time Factors; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D014662:Vasoconstrictor Agents; D009638:Norepinephrine