title: Skeleton and glucose metabolism: a bone-pancreas loop.
abstract: Bone has been considered a structure essential for mobility, calcium homeostasis, and hematopoietic function. Recent advances in bone biology have highlighted the importance of skeleton as an endocrine organ which regulates some metabolic pathways, in particular, insulin signaling and glucose tolerance. This review will point out the role of bone as an endocrine "gland" and, specifically, of bone-specific proteins, as the osteocalcin (Ocn), and proteins involved in bone remodeling, as osteoprotegerin, in the regulation of insulin function and glucose metabolism.
authors: Section of Pediatrics, Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", 70124 Bari, Italy.
authors: Maria Felicia
authors: 0000-0002-1899-8337
authors: MF
authors: Faienza
authors: Section of Pediatrics, Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", 70124 Bari, Italy.
authors: Vincenza
authors: V
authors: Luce
authors: Section of Pediatrics, Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", 70124 Bari, Italy.
authors: Annamaria
authors: A
authors: Ventura
authors: Section of Human Anatomy and Histology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70124 Bari, Italy.
authors: Graziana
authors: 0000-0001-8501-5399
authors: G
authors: Colaianni
authors: Section of Human Anatomy and Histology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70124 Bari, Italy.
authors: Silvia
authors: S
authors: Colucci
authors: Section of Pediatrics, Department of Biomedical Sciences and Human Oncology, University of Bari "A. Moro", 70124 Bari, Italy.
authors: Luciano
authors: L
authors: Cavallo
authors: Section of Human Anatomy and Histology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70124 Bari, Italy.
authors: Maria
authors: M
authors: Grano
authors: Section of Human Anatomy and Histology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70124 Bari, Italy.
authors: Giacomina
authors: 0000-0002-0681-1432
authors: G
authors: Brunetti