title: Resveratrol Improves Survival and Prolongs Life Following Hemorrhagic Shock.
abstract: Resveratrol has been shown to potentiate mitochondrial function and extend longevity; however, there is no evidence to support whether resveratrol can improve survival or prolong life following hemorrhagic shock. We sought to determine whether (a) resveratrol can improve survival following hemorrhage and resuscitation and (b) prolong life in the absence of resuscitation. Using a hemorrhagic injury (HI) model in the rat, we describe for the first time that the naturally occurring small molecule, resveratrol, may be an effective adjunct to resuscitation fluid. In a series of three sets of experiments we show that resveratrol administration during resuscitation improves survival following HI (p < 0.05), resveratrol and its synthetic mimic SRT1720 can significantly prolong life in the absence of resuscitation fluid (<30 min versus up to 4 h; p < 0.05), and resveratrol as well as SRT1720 restores left ventricular function following HI. We also found significant changes in the expression level of mitochondria-related transcription factors Ppar-α and Tfam, as well as Pgc-1α in the left ventricular tissues of rats subjected to HI and treated with resveratrol. The results indicate that resveratrol is a strong candidate adjunct to resuscitation following severe hemorrhage.
authors: Department of Laboratory Sciences, Georgia Regents University, Augusta, Georgia, United States of America.
authors: Ahmar
authors: A
authors: Ayub
authors: Department of Laboratory Sciences, Georgia Regents University, Augusta, Georgia, United States of America.
authors: Ninu
authors: N
authors: Poulose
authors: Department of Laboratory Sciences, Georgia Regents University, Augusta, Georgia, United States of America.|Department of Surgery, Georgia Regents University, Augusta, Georgia, United States of America.|Department of Biochemistry and Molecular Biology, Georgia Regents University, Augusta, Georgia, United States of America.
authors: Raghavan
authors: R
authors: Raju
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D004195:Disease Models, Animal; D053208:Kaplan-Meier Estimate; D008297:Male; D009026:Mortality; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D000077185:Resveratrol; D012720:Severity of Illness Index; D012771:Shock, Hemorrhagic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000401:mortality*; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol