title: Nonalcoholic fatty liver may increase the risk of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives.
abstract: BACKGROUND
  Fatty liver is a common disease in developed countries. We investigated the frequency of operation in patients with fatty liver and the frequency of cancer in their first-degree relatives.
  
  
  METHODS
  In this study, we evaluated 105 patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD), 121 patients with hepatitis C (61 patients with fatty liver and 60 patients without fatty liver), 50 patients with inflammatory bowel disease (IBD), and 109 patients with dyspepsia as a control group.
  
  
  RESULTS
  There was no difference for sex, mean age, and marital status among the groups, except that patients with IBD were younger than others (p < 0.001). The frequency of cancer in family was as follows: 18 % in IBD, 9 % in dyspepsia, 28 % in hepatitis C with hepatic steatosis, 21.5 % in hepatitis C without steatosis, and 27 % in NAFLD (p = 0.006). Then, we divided the study group into two groups-group 1: IBD + dyspepsia + hepatitis C without hepatic steatosis, and group 2: hepatitis C with hepatic steatosis + NAFLD-and performed the same analysis. We found that the frequency of cancer in family was 16 % in group 1 (the patients without fatty liver) vs. 24.4 % in group 2 (those with fatty liver; p = 0.037). We also investigated the rate of operation in patients. The results were as follows: 33 % in group 1 vs. 43 % in group 2 (p = 0.043).
  
  
  CONCLUSIONS
  Independently of the underlying chronic diseases, occurrence of fat in the liver increased the frequency of operation in patients with fatty liver and the rate of cancer in their first-degree relatives. Understanding the underlying causes of fatty liver forms might decrease the cancer frequency in the population and number of operation in patients with fatty liver.
authors: Division of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey. metin_basaranoglu@yahoo.com.
authors: Metin
authors: M
authors: Basaranoglu
authors: Division of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
authors: Billur
authors: B
authors: Canbakan
authors: Division of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
authors: Kemal
authors: K
authors: Yildiz
authors: Division of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
authors: Bahadir
authors: B
authors: Ceylan
authors: Division of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
authors: Birol
authors: B
authors: Baysal
authors: Division of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
authors: Omer
authors: O
authors: Uysal
authors: Division of Gastroenterology, Department of Internal Medicine, Medical School, BezmiAlem Vakif University, 34000, Istanbul, Turkey.
authors: Hakan
authors: H
authors: Senturk
mesh_terms: D000328:Adult; D000368:Aged; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006498:Hepatectomy / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology / Q000235:genetics* / Q000601:surgery*; D015995:Prevalence; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D014600:Utilization Review
keywords: Cancer; Dyspepsia; Fatty liver; Hepatitis C; Inflammatory bowel disease; Nonalcoholic fatty liver disease; Operation; Surgery