title: The interaction of new piroxicam analogues with lipid bilayers--a calorimetric and fluorescence spectroscopic study.
abstract: The purpose of the present paper was to assess the ability of new piroxicam analogues to interact with the lipid bilayers. The results of calorimetric and fluorescence spectroscopic experiments of two new synthesized analogues of piroxicam, named PR17 and PR18 on the phase behavior of phospholipid bilayers and fluorescence quenching of fluorescent probes (Laurdan and Prodan), which molecular location within membranes is known with certainty, are shown in present work. The presented results revealed that, depending on the details of chemical structure, the studied compounds penetrated the lipid bilayers.
authors: Jadwiga
authors: J
authors: Maniewska
authors: Berenika
authors: B
authors: Szczęśniak-Sięga
authors: Andrzej
authors: A
authors: Poła
authors: Kamila
authors: K
authors: Sroda-Pomianek
authors: Wiesław
authors: W
authors: Malinka
authors: Krystyna
authors: K
authors: Michalak
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D002151:Calorimetry; D004530:Egg Yolk / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010713:Phosphatidylcholines / Q000737:chemistry*; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D021281:Quantitative Structure-Activity Relationship; D013050:Spectrometry, Fluorescence; D013817:Thermography
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010894:Piroxicam; D015060:1,2-Dipalmitoylphosphatidylcholine