title: A faith in the coherence of the living world.
abstract: In this review, I compare the development of Monod's intellectual leadership in two fields, the regulation of enzyme biosynthesis and the control of enzymatic activity. I characterize the comings and goings between his scrupulous analysis of a given model system, his ability to compare the outcome with very distant experimental results, his audacity in formulating, then a physical interpretation of this convergence through a unifying mechanism. Finally, I briefly discuss how his attitude has durably impacted the whole field of molecular biology.
authors: Institut Pasteur, 25-28, rue du Docteur-Roux, 75724 Paris cedex 15, France. Electronic address: henri.buc@pasteur.fr.
authors: Henri
authors: H
authors: Buc
mesh_terms: D000494:Allosteric Regulation; D004798:Enzymes / Q000096:biosynthesis*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008967:Molecular Biology / Q000266:history*
chemical_list: D004798:Enzymes
keywords: Allosteric control; Contrôle allostérique; Contrôle transcriptionnel; Jacques Monod; Transcriptional control