title: Neurofilament light chain level in cerebrospinal fluid can differentiate Parkinson's disease from atypical parkinsonism: Evidence from a meta-analysis.
abstract: A reliable test that facilitates the accurate diagnosis of Parkinson's and disorders will help with both, clinical management and therapeutic research. In this context, neurofilament light chain (NFL) is candidate for a biomarker in cerebrospinal fluid (CSF). A comprehensive literature search yielded 4 eligible studies. We expressed between-group difference of NFL concentration in CSF as the standardized mean difference. Four studies involved 166 Parkinson's disease (PD), 116 multiple system atrophy (MSA) and 73 progressive supranuclear palsy (PSP) patients. Patients with MSA showed higher concentration of NFL concentration in CSF than those with PD (standardized mean difference=1.60, P<0.0001). These studies were homogeneous (P=0.17). NFL in CSF in PSP was significantly elevated relative to PD with homogeneous studies (standardized mean difference=2.04, P<0.0001; P=0.99). The present meta-analysis suggested that NFL concentration in CSF in MSA and PSP was significantly increased relative to PD, and that this could help us to separate PD from atypical parkinsonian syndromes.
authors: Department of Clinical Neuroscience, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan. Electronic address: dwsako@yahoo.co.jp.
authors: Wataru
authors: W
authors: Sako
authors: Department of Clinical Neuroscience, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan.
authors: Nagahisa
authors: N
authors: Murakami
authors: Department of Clinical Neuroscience, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan.
authors: Yuishin
authors: Y
authors: Izumi
authors: Department of Clinical Neuroscience, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan.
authors: Ryuji
authors: R
authors: Kaji
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D003937:Diagnosis, Differential; D006801:Humans; D019578:Multiple System Atrophy / Q000134:cerebrospinal fluid*; D016900:Neurofilament Proteins / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D020734:Parkinsonian Disorders / Q000134:cerebrospinal fluid / Q000175:diagnosis; D013494:Supranuclear Palsy, Progressive / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D016900:Neurofilament Proteins
keywords: Cerebrospinal fluid; Meta-analysis; Multiple system atrophy; Neurofilament light chain; Parkinson's disease; Progressive supranuclear palsy