title: Immune profile of IgA-dominant diffuse proliferative glomerulonephritis.
abstract: The diagnosis of IgA-dominant post-infectious glomerulonephritis (PIGN) may be challenging, as it must be differentiated from that of active IgA nephropathy. Predominant clinicopathologic features of IgA-dominant PIGN substantially overlap with those of active IgA nephropathy. Here, we present a case of a 67-year-old woman with rapidly rising serum creatinine, proteinuria and severe hypertension. The kidney biopsy findings included some features of IgA-dominant PIGN while others were more consistent with classical IgA nephropathy. We describe this patient's immune profile at the time of acute kidney injury and review the literature regarding differentiation of the two entities.
authors: Division of Nephrology, Department of Medicine , University of Alabama at Birmingham , Birmingham, AL , USA.
authors: Eric
authors: E
authors: Wallace
authors: Department of Microbiology , University of Alabama at Birmingham , Birmingham, AL , USA.
authors: Nicolas
authors: N
authors: Maillard
authors: Department of Microbiology , University of Alabama at Birmingham , Birmingham, AL , USA.
authors: Hiroyuki
authors: H
authors: Ueda
authors: Department of Microbiology , University of Alabama at Birmingham , Birmingham, AL , USA.
authors: Stacy
authors: S
authors: Hall
authors: Department of Pathology , University of Alabama at Birmingham , Birmingham, AL , USA.
authors: Huma
authors: H
authors: Fatima
authors: Department of Microbiology , University of Alabama at Birmingham , Birmingham, AL , USA.
authors: Jan
authors: J
authors: Novak
authors: Division of Nephrology, Department of Medicine , University of Alabama at Birmingham , Birmingham, AL , USA ; Department of Microbiology , University of Alabama at Birmingham , Birmingham, AL , USA.
authors: Bruce A
authors: BA
authors: Julian
keywords: IgA; IgA dominant post-infectious glomerulonephritis; IgA nephropathy