title: Benzene exposure and risk of lymphohaematopoietic cancers in 25 000 offshore oil industry workers.
abstract: BACKGROUND
  The aim of this work was to examine the risk of lymphohaematopoietic (LH) cancer according to benzene exposure among offshore workers.
  
  
  METHODS
  Cancer registry data were used to identify 112 cancer cases diagnosed during 1999-2011 in a cohort of 24 917 Norwegian men reporting offshore work between 1965 and 1999. Analyses were conducted according to a stratified case-cohort design with a reference subcohort of 1661 workers. Cox regression was used to estimate hazard ratios with 95% confidence intervals, adjusted for other benzene exposure and smoking.
  
  
  RESULTS
  Most workers were exposed to benzene for <15 years. The upper range values of average intensity and cumulative exposure were estimated to 0.040 p.p.m. and 0.948 p.p.m.-years, respectively. Risks were consistently elevated among exposed workers for all LH cancers combined and for most subgroups, although case numbers were small and yielded imprecise risk estimates. There was evidence of dose-related risk patterns according to cumulative exposure for acute myeloid leukaemia (AML), multiple myeloma (MM) (P trends 0.052 and 0.024, respectively), and suggestively so for chronic lymphocytic leukaemia (CLL) according to average intensity (P trend 0.094).
  
  
  CONCLUSIONS
  Our results support an association between cumulative and intensity metrics of low-level benzene exposure and risk for AML, MM, and suggestively for CLL.
authors: Department of Research, Cancer Registry of Norway, P.O. Box 5313 Majorstuen, Oslo N-0304, Norway.
authors: J S
authors: JS
authors: Stenehjem
authors: Department of Research, Cancer Registry of Norway, P.O. Box 5313 Majorstuen, Oslo N-0304, Norway.
authors: K
authors: K
authors: Kjærheim
authors: Department of Global Public Health and Primary Care, University of Bergen, Bergen N-5020, Norway.
authors: M
authors: M
authors: Bråtveit
authors: Department of Mathematics, University of Oslo, Oslo N-0316, Norway.
authors: S O
authors: SO
authors: Samuelsen
authors: 1] Population Health Research Institute, St George's University of London, London SW17 0RE, UK [2] Department of Pharmaceutical Sciences, University of Eastern Piedmont, Novara 28100, Italy.
authors: F
authors: F
authors: Barone-Adesi
authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
authors: N
authors: N
authors: Rothman
authors: Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
authors: Q
authors: Q
authors: Lan
authors: Department of Research, Cancer Registry of Norway, P.O. Box 5313 Majorstuen, Oslo N-0304, Norway.
authors: T K
authors: TK
authors: Grimsrud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001554:Benzene / Q000009:adverse effects*; D016022:Case-Control Studies; D015331:Cohort Studies; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D006801:Humans; D007938:Leukemia / Q000139:chemically induced / Q000453:epidemiology*; D008223:Lymphoma / Q000139:chemically induced / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D010578:Petroleum / Q000009:adverse effects*; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D010578:Petroleum; D001554:Benzene