title: Meningococcal meningitis: vaccination outbreak response and epidemiological changes in the African meningitis belt.
abstract: The main approach to controlling epidemics of meningococcal meningitis in the African meningitis belt has been reactive vaccination campaigns with serogroup A polysaccharide vaccine once the outbreak reached an incidence threshold. Early reactive vaccination is effective in reducing morbidity and mortality. A recent paper in International Health has shown that earlier reactive vaccination campaigns may be even more effective than increasing the coverage area of vaccination. Monovalent serogroup A conjugate vaccine programs have recently been launched to prevent transmission in endemic areas in the African meningitis belt. Conjugate vaccines can induce immunological memory and have impact on pharyngeal carriage. However, reactive vaccination still has a role to play taking into account the dynamic changes in the epidemiology of meningitis in this area.
authors: Neurology Department, Raigmore hospital, Old Perth road, Inverness, IV2 3UJ, UK and Universitat Internacional de Cataluya (UIC), Barcelona, Spain javier.carodartal@nhs.net.
authors: Francisco Javier
authors: FJ
authors: Carod Artal
mesh_terms: D000349:Africa / Q000453:epidemiology; D004196:Disease Outbreaks / Q000517:prevention & control; D058872:Epidemics / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D008585:Meningitis, Meningococcal / Q000453:epidemiology / Q000517:prevention & control*; D022401:Meningococcal Vaccines; D014611:Vaccination; D018074:Vaccines, Conjugate
chemical_list: D022401:Meningococcal Vaccines; D018074:Vaccines, Conjugate
keywords: Conjugate vaccine; Meningitis surveillance; Neisseria meningitides; Polysaccharide vaccine; Serogroup A; Vaccination outbreak response