title: The mediating effect of coping on the association between fatigue and quality of life in patients with multiple sclerosis.
abstract: Fatigue, as one of the most frequent symptoms in patients with multiple sclerosis (MS), has various adverse effects on the physical and mental health-related quality of life (PCS, MCS) of patients. The aim of this study was to explore whether coping mediates the relationship between fatigue and PCS and MCS. We collected data from 154 consecutive MS patients (76.0% women; mean age 40.0 ± 9.9). Patients completed the Short-Form Health Survey (SF-36), the multidimensional fatigue inventory (MFI-20) and the coping self-efficacy scale. The mediating effect of coping was analysed using linear regressions and the Sobel z-test. In PCS significant mediation was found in some of the fatigue dimensions (general, physical and reduced Motivation), while in MCS, it was significant in all dimensions. These results can be implemented into educational programmes for patients, their caregivers or physicians, and can also be helpful in the treatment process.
authors: a Faculty of Medicine, Department of Social Medicine, Institute of Public Health , Safarik University , Kosice , Slovakia.
authors: Pavol
authors: P
authors: Mikula
authors: Iveta
authors: I
authors: Nagyova
authors: Martina
authors: M
authors: Krokavcova
authors: Marianna
authors: M
authors: Vitkova
authors: Jaroslav
authors: J
authors: Rosenberger
authors: Jarmila
authors: J
authors: Szilasiova
authors: Zuzana
authors: Z
authors: Gdovinova
authors: Johan W
authors: JW
authors: Groothoff
authors: Jitse P
authors: JP
authors: van Dijk
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D005221:Fatigue / Q000209:etiology / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D020528:Multiple Sclerosis, Chronic Progressive / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D020377:Self Efficacy; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: coping; fatigue; mental component of quality of life; multiple sclerosis; physical component of quality of life