title: Catalytic enantioselective intramolecular aza-diels-alder reactions.
abstract: A readily available chiral Brønsted acid was identified as an efficient catalyst for intramolecular Povarov reactions. Polycyclic amines containing three contiguous stereogenic centers were obtained with excellent stereocontrol in a single step from secondary anilines and aldehydes possessing a pendent dienophile. These transformations constitute the first examples of catalytic enantioselective intramolecular aza-Diels-Alder reactions.
authors: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://seidel-group.com/
authors: Chang
authors: C
authors: Min
authors: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://seidel-group.com/
authors: Chih-Tsung
authors: CT
authors: Lin
authors: Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854 (USA) http://seidel-group.com/. seidel@rutchem.rutgers.edu.
authors: Daniel
authors: D
authors: Seidel
keywords: Brønsted acids; asymmetric catalysis; cycloaddition; ion pairs; organocatalysis