title: Extra-pulmonary small cell carcinoma in the head and neck setting: the role of prophylactic cranial irradiation.
abstract: Head-and-neck small cell carcinoma (HN-SmCC) is a rare entity and there is limited data to support management decisions. The role of prophylactic cranial irradiation (PCI) remains controversial. A retrospective review of 21 consecutive HN-SmCCs was performed. No case received PCI. The 2-year overall survival, local, regional and distant control rates were 65%, 94%, 88%, and 76% respectively. Despite no patient receiving PCI, brain metastases were uncommon (n=2) and routine use of PCI is not justified in this population.
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Matthew
authors: M
authors: Mason
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Meredith
authors: M
authors: Giuliani
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Shao Hui
authors: SH
authors: Huang
authors: Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Wei
authors: W
authors: Xu
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Andrew
authors: A
authors: Hope
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: John
authors: J
authors: Kim
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Andrew
authors: A
authors: Bayley
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: B C
authors: BC
authors: John Cho
authors: Department of Department of Otolaryngology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON, Canada M5T 2M9.
authors: David
authors: D
authors: Goldstein
authors: Division of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Raymond W
authors: RW
authors: Jang
authors: Department of Pathology, University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Bayardo Perez
authors: BP
authors: Ordonez
authors: Department of Radiation Oncology, Cape Breton Cancer Centre, 1482 George Street, Sydney, NS B1P 1P3, Canada.
authors: Sandra
authors: S
authors: Wajstaub
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: John
authors: J
authors: Waldron
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Robert
authors: R
authors: Dinniwell
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Brian
authors: B
authors: O'Sullivan
authors: Department of Radiation Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5T 2M9, Canada.
authors: Jolie
authors: J
authors: Ringash
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000401:mortality* / Q000556:secondary / Q000628:therapy*; D016371:Cranial Irradiation / Q000706:statistics & numerical data*; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
keywords: Brain metastases; Chemoradiotherapy; Head and neck carcinoma; IMRT; Local failure; Neurocognition; Patterns of failure; Prophylactic cranial irradiation; Small cell carcinoma; Whole brain radiation