title: New Chemometrics Mode Based on Adjacent Data Points' Differences for the Simultaneous Determination of Clopidogrel, Atorvastatin, and Aspirin in their Combined Ternary Drug Formulation.
abstract: A new method is proposed for the analysis of a ternary mixture composed of clopidogrel, atorvastatin, and aspirin without prior separation steps. The method combines the advantages of the mean centering of ratio spectra and derivative spectrophotometric methods. It is based on using the difference between adjacent data points in the absorbance spectra. The principal advantage of this method is the use of absorbance data, and not derivative data; hence the signal-to-noise ratio is not diminished. The mathematical explanation of the procedure is illustrated. Beer's law was valid in the concentration range 0.3-35 μg.mL(-1) for CLOP, 0.5-30 μg.mL(-1) for ATOR, and 1-40 μg.mL(-1) for ASP. Mean recoveries were obtained as 100.2, 100.1, and 100.2% for CLOP, ATOR, and ASP, respectively, in the prepared synthetic mixtures. The method has been successfully applied to the simultaneous determination of ternary mixtures of aspirin, clopidogrel bisulphate, and atorvastatin calcium. The analytical characteristics of the method were calculated. The results showed that the new method is simple, rapid, accurate, and precise.
authors: Analytical Chemistry, Department of Chemistry, Alaqsa University, P.O.Box 4051, Gaza, Palestine.
authors: R'afat Mahmoud
authors: RM
authors: Nejem
authors: Pharmaceutical Analytical Chemistry, Department of Chemistry, Alaqsa University, P.O.Box 4051, Gaza, Palestine.
authors: Mahmoud Mohamed
authors: MM
authors: Issa
authors: Inorganic Analytical Chemistry, Department of Chemistry, Alaqsa University, P.O.Box 4051 Gaza, Palestine.
authors: Alaa Abu
authors: AA
authors: Shanab
authors: National Institute of Research for Electrochemistry and Condensed Matter, Bucharest, Romania.
authors: Raluca-Ioana
authors: RI
authors: Stefan-Van Staden
authors: Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Center, Dokki, Cairo 12311, Egypt.
authors: Hassan Y
authors: HY
authors: Aboul-Enein
keywords: Aspirin; Atorvastatin calcium; Clopidogrel bisulphate; DBADP; MCR