title: Methylene Blue as a Photosensitizer and Redox Agent: Synthesis of 5-Hydroxy-1H-pyrrol-2(5H)-ones from Furans.
abstract: A highly efficient and general singlet-oxygen-initiated one-pot transformation of readily accessible furans into 5-hydroxy-1H-pyrrol-2(5H)-ones has been developed. The methodology was extended to the synthesis of other high-value α,β-unsaturated γ-lactams. This useful set of transformations relies not only on the photosensitizing ability of methylene blue, but also on its redox properties: properties that have until now been virtually ignored in a synthetic context.
authors: Department of Chemistry, University of Crete, Vasilika Vouton, 71003, Iraklion, Crete (Greece) http://www.chemistry.uoc.gr/vassilikogiannakis.
authors: Dimitris
authors: D
authors: Kalaitzakis
authors: Department of Chemistry, University of Crete, Vasilika Vouton, 71003, Iraklion, Crete (Greece) http://www.chemistry.uoc.gr/vassilikogiannakis.
authors: Antonia
authors: A
authors: Kouridaki
authors: Department of Chemistry, University of Crete, Vasilika Vouton, 71003, Iraklion, Crete (Greece) http://www.chemistry.uoc.gr/vassilikogiannakis.
authors: Dimitris
authors: D
authors: Noutsias
authors: Department of Chemistry, University of Crete, Vasilika Vouton, 71003, Iraklion, Crete (Greece) http://www.chemistry.uoc.gr/vassilikogiannakis.
authors: Tamsyn
authors: T
authors: Montagnon
authors: Department of Chemistry, University of Crete, Vasilika Vouton, 71003, Iraklion, Crete (Greece) http://www.chemistry.uoc.gr/vassilikogiannakis. vasil@chemistry.uoc.gr.
authors: Georgios
authors: G
authors: Vassilikogiannakis
keywords: furan oxidation; methylene blue; singlet oxygen; sustainable chemistry; α,β-unsaturated γ-lactams