title: Maternal serum pregnancy-associated plasma protein-A levels in hyperemesis gravidarum: a prospective case control study.
abstract: OBJECTIVE
  To investigate if maternal serum pregnancy-associated plasma protein-A levels are affected in hyperemesis gravidarum (HG).
  
  
  METHODS
  A prospective case control study was conducted in 169 HG cases who had one or more antepartum hospitilization for HG. The control pregnancies were 132 and were selected randomly among all women who had first trimester prenatal screening in antenatal outpatient clinic between 2011 and 2012.
  
  
  RESULTS
  Maternal serum pregnancy-associated plasma protein-A levels were significantly higher in hyperemesis gravidarum group compared with control group (p = 0.002 p < 0.05 95% CI). Power analysis of independent sample t-test, two-sided, for pregnancy-associated plasma protein-A was 0.88. Maternal serum free beta-human chorionic gonadotropin values were not different between two groups (p > 0.05).
  
  
  CONCLUSIONS
  Increased pregnancy-associated plasma protein-A levels associated with HG, even after excluding potential cofounders.
authors: B S
authors: BS
authors: Unlu
authors: H
authors: H
authors: Energin
authors: Y
authors: Y
authors: Yildiz
authors: E
authors: E
authors: Unlu
authors: E G
authors: EG
authors: Yapar Eyi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011296:Prenatal Diagnosis / Q000379:methods*; D011446:Prospective Studies
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A