title: Evaluation of inflammatory and oxidative biomarkers in children with well-controlled congenital hypothyroidism.
abstract: OBJECTIVE
  To investigate well-controlled congenital hypothyroidism on the markers associated with early kidney injury and oxidative DNA damage.
  
  
  METHODS
  Twenty-three children with euthyroid congenital hypothyroidism aged 3-6 years and 19 age- and gender-matched controls were enrolled. Serum levels of albumin, C-reactive protein, cysteine C, globulin, pre-albumin, and total protein were detected. Urine levels of albumin, fibrin degradation products, IgG, β2-microglobulin, and 8-hydroxydeoxyguanosine (8-OHdG) were also measured. Clinical and biochemical characteristics were evaluated between the two groups.
  
  
  RESULTS
  Serum levels of C-reactive protein were higher, but pre-albumin was lower in patients with congenital hyperthyroidism compared with the controls (all p<0.001). Urinary levels of IgG were higher in patients with congenital hyperthyroidism than in the controls (p=0.011). However, urinary levels of albumin excretion and 8-OHdG were similar to those in the controls. Serum pre-albumin levels were negatively correlated with urinary 8-OHdG levels (r=-0.479, p=0.016) in patients with congenital hypothyroidism.
  
  
  CONCLUSIONS
  It is concluded that inflammatory and oxidative markers were slightly altered in well-controlled congenital hypothyroidism. The levels of urinary 8-OHdG and albumin excretion were not significantly different.
authors: Ya-Li
authors: YL
authors: Qiu
authors: Hong
authors: H
authors: Zhu
authors: Shao-Gang
authors: SG
authors: Ma
authors: Hong
authors: H
authors: Liu
authors: Qing
authors: Q
authors: Li
authors: Chun-Mei
authors: CM
authors: Ji
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis*; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000150:complications*; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D018384:Oxidative Stress; D011379:Prognosis
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002097:C-Reactive Protein; D003849:Deoxyguanosine