title: Joint effects of serum uric acid and body mass index on risk of prehypertension in Chinese population.
abstract: BACKGROUND
  There are few data available on the association between serum uric acid (UA) and prehypertension when hypertension prevention efforts may be applicable.
  
  
  METHODS
  We performed a cross-sectional study to evaluate risk of prehypertension and its association with serum UA and other confounding factors. Levels of serum UA, blood pressure, body mass index (BMI) and some related factors were detected.
  
  
  RESULTS
  Participants with prehypertension had higher levels of serum UA and BMI. Compared to those with normotension, the multivariate-adjusted odds ratios [ORs, 95% confidence interval (CI)] for men with prehypertension were 1.33 (95% CI, 1.08-3.91) of serum UA and 1.21 (95% CI, 1.17-1.29) of BMI. In women, the ORs were 1.96 (95% CI, 1.21-3.46) and 1.28 (95% CI, 1.14-2.46), respectively. Increasing serum UA and BMI were associated with increased risk of prehypertension. Compared with the lowest quartiles, the highest serum UA and BMI quartiles entailed >4.4 times greater risk of prehypertension. In sex-specific analysis, OR was 2.41 (95% CI, 1.55-3.75) for men and 7.37 (95% CI, 4.16-13.0) for women.
  
  
  CONCLUSIONS
  Both high serum UA and high BMI are associated with risk of prehypertension. Individuals with higher serum UA and BMI simultaneously have a higher risk for prehypertension, especially for women.
authors: Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; National Key Clinical Department of Laboratory Medicine, Nanjing 210029, China; Department of Laboratory Medicine, Jiangsu Shengze Hospital, Suzhou 215228, China.
authors: Li
authors: L
authors: Jiang
authors: Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors: Dongping
authors: D
authors: Mo
authors: Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; National Key Clinical Department of Laboratory Medicine, Nanjing 210029, China.
authors: Ruixia
authors: R
authors: Yang
authors: Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; National Key Clinical Department of Laboratory Medicine, Nanjing 210029, China.
authors: Qin
authors: Q
authors: Ye
authors: Department of Laboratory Medicine, Jiangsu Shengze Hospital, Suzhou 215228, China.
authors: Jing
authors: J
authors: Wu
authors: Department of Laboratory Medicine, Jiangsu Shengze Hospital, Suzhou 215228, China.
authors: Gang
authors: G
authors: Yu
authors: Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; National Key Clinical Department of Laboratory Medicine, Nanjing 210029, China. Electronic address: xu_jian79@163.com.
authors: Jian
authors: J
authors: Xu
authors: Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; National Key Clinical Department of Laboratory Medicine, Nanjing 210029, China. Electronic address: sypan@njmu.edu.cn.
authors: Shiyang
authors: S
authors: Pan
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods; D058246:Prehypertension / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology*; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D014527:Uric Acid
keywords: Body mass index; Prehypertension; Serum uric acid