title: Building endocytic pits without clathrin.
abstract: How endocytic pits are built in clathrin- and caveolin-independent endocytosis still remains poorly understood. Recent insight suggests that different forms of clathrin-independent endocytosis might involve the actin-driven focusing of membrane constituents, the lectin-glycosphingolipid-dependent construction of endocytic nanoenvironments, and Bin-Amphiphysin-Rvs (BAR) domain proteins serving as scaffolding modules. We discuss the need for different types of internalization processes in the context of diverse cellular functions, the existence of clathrin-independent mechanisms of cargo recruitment and membrane bending from a biological and physical perspective, and finally propose a generic scheme for the formation of clathrin-independent endocytic pits.
authors: Institut Curie, PSL Research University, Endocytic Trafficking and Therapeutic Delivery Group, 26 rue d'Ulm, 75248 Paris Cedex 05, France; Centre National de la Recherche Scientifique UMR3666, 75005 Paris, France; and INSERM U1143, 75005 Paris, France.
authors: Ludger
authors: L
authors: Johannes
authors: University of Queensland, Institute for Molecular Bioscience and Centre for Microscopy and Microanalysis, St Lucia QLD 4072, Australia.
authors: Robert G
authors: RG
authors: Parton
authors: Institut Curie, PSL Research University, Membrane and Cell Functions Group, 26 rue d'Ulm, 75248 Paris Cedex 05, France; Centre National de la Recherche Scientifique UMR168, 75005 Paris, France; and Université Pierre et Marie Curie, 75252 Paris, France.
authors: Patricia
authors: P
authors: Bassereau
authors: National Centre for Biological Sciences, Cellular Organization and Signaling Group, and at Institute for Stem Cell Biology and Regenerative Medicine, UAS-GKVK Campus, 560 065 Bangalore, India.
authors: Satyajit
authors: S
authors: Mayor
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D037102:Lectins / Q000378:metabolism; D053858:Metabolic Networks and Pathways
chemical_list: D000199:Actins; D002966:Clathrin; D037102:Lectins