title: Prognostic value of monocyte and neutrophils to lymphocytes ratio in patients with metastatic soft tissue sarcoma.
abstract: Metastatic soft tissue sarcomas (STS) represent enormous challenges to improve the low survival rate, which is almost the same as past 2 decades ago. Prognosis of cancer patients are based not only on tumor-related factors but also on host-related factors, particularly systemic inflammatory response. We evaluated the association among possible risk factors and survival for metastatic STS by reviewed a single-institution nearly 50-year experience. We found that both monocyte ratio and NLR ratio were significant prognostic predictors for OS and PFS of metastatic STS. And patients with monocyte ratio or NLR ratio > 1 should be screened out as candidates for more intensive or aggressive multimodality treatments and more aggressive follow-up. For this reason, this result could serve as a basis for future prospective study.
authors: Sun Yat-sen University Cancer Center, Guangzhou, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|State Key Laboratory of Oncology in South China, Guangzhou, China.|University of California, San Francisco, CA, USA.
authors: Long
authors: L
authors: Jiang
authors: Sun Yat-sen University Cancer Center, Guangzhou, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|State Key Laboratory of Oncology in South China, Guangzhou, China.
authors: Shanshan
authors: S
authors: Jiang
authors: Sun Yat-sen University Cancer Center, Guangzhou, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|State Key Laboratory of Oncology in South China, Guangzhou, China.
authors: Dongrong
authors: D
authors: Situ
authors: Sun Yat-sen University Cancer Center, Guangzhou, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|State Key Laboratory of Oncology in South China, Guangzhou, China.
authors: Yongbin
authors: Y
authors: Lin
authors: Sun Yat-sen University Cancer Center, Guangzhou, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|State Key Laboratory of Oncology in South China, Guangzhou, China.
authors: Han
authors: H
authors: Yang
authors: Sun Yat-sen University Cancer Center, Guangzhou, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|State Key Laboratory of Oncology in South China, Guangzhou, China.
authors: Yuanfang
authors: Y
authors: Li
authors: Sun Yat-sen University Cancer Center, Guangzhou, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|State Key Laboratory of Oncology in South China, Guangzhou, China.
authors: Hao
authors: H
authors: Long
authors: Sun Yat-sen University Cancer Center, Guangzhou, China.|Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.|State Key Laboratory of Oncology in South China, Guangzhou, China.
authors: Zhiwei
authors: Z
authors: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D009504:Neutrophils; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012509:Sarcoma / Q000097:blood / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D055815:Young Adult
keywords: immunity; metastasis; prognosis; soft tissue sarcoma