title: A mitochondrion targeting fluorescent probe for imaging of intracellular superoxide radicals.
abstract: An amine-reactive fluorogenic molecule specifically turned on by superoxide radicals (O2˙(-)) was synthesized and coupled to a mitochondrial (MT) targeting peptide. The obtained probe showed superior uptake and MT targeting capabilities; and successfully detected the change in O2˙(-) levels in cells treated with chemical stimuli or single-walled carbon nanotubes.
authors: College of Chemistry, Chemical and Biological Engineering, Donghua University, Shanghai 201620, P. R. China.
authors: Fang
authors: F
authors: Si
authors: Yang
authors: Y
authors: Liu
authors: Kelu
authors: K
authors: Yan
authors: Wenwan
authors: W
authors: Zhong
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D000818:Animals; D002460:Cell Line; D005456:Fluorescent Dyes / Q000032:analysis / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D015394:Molecular Structure; D037742:Nanotubes, Carbon / Q000737:chemistry; D013481:Superoxides / Q000032:analysis* / Q000737:chemistry
chemical_list: D000588:Amines; D005456:Fluorescent Dyes; D037742:Nanotubes, Carbon; D013481:Superoxides