title: Ghrelin O Acyl Transferase (GOAT) as a Novel Metabolic Regulatory Enzyme.
abstract: BACKGROUND
  Obesity and Type 2 Diabetes Mellitus (T2DM) presents a growing threat to the global health. Evidences highlight an important role of ghrelin as a key regulator of glucose metabolism. The physiological functions of ghrelin are mediated by enzyme ghrelin-O-acyltransferase (GOAT) which is capable of generating the active form of this metabolic hormone. However, its exact mechanism of action and influence on energy balance and glucose metabolism is yet to be explored.
  
  
  OBJECTIVE
  To review the physiological role of GOAT in the regulation of energy balance and glucose metabolism and explore the potential therapeutic avenues of modulators of GOAT to counter the progression of obesity and T2DM.
  
  
  METHODS
  Publications were sought through electronic searches. The bibliographies of all papers, book, chapters and editorials were scanned and hand searches were also conducted for journals, and conference proceedings.
  
  
  CONCLUSIONS
  GOAT peptide modulates the insulin secretion as well as insulin sensitivity. Modulators of GOAT signaling like inhibitors of GOAT increases insulin secretion, enhance peripheral insulin sensitivity and thus counters obesity and T2DM. Modulators of GOAT can be a probable therapy for modifying food intake and for countering obesity and T2DM.
authors: Professor, Department of Physiology, JN Medical College, Datta Meghe Institute of Medical Sciences , Wardha, Maharashtra, India .
authors: Mahalaqua Nazli
authors: MN
authors: Khatib
authors: Associate Professor, Department of Medicine, JN Medical College, Datta Meghe Institute of Medical Sciences , Wardha, Maharashtra, India .
authors: Shilpa
authors: S
authors: Gaidhane
authors: Professor, Department of Community Medicine, JN Medical College, Datta Meghe Institute of Medical Sciences , Wardha, Maharashtra, India .
authors: Abhay M
authors: AM
authors: Gaidhane
authors: Senior Lecturer in International Health ScHARR, University of Sheffield, UK and Centre for public Health Liverpool Johns Moores University , Liverpool, UK .
authors: Padam
authors: P
authors: Simkhada
authors: Professor, Department of Community Medicine, JN Medical College, Datta Meghe Institute of Medical Sciences , Wardha, Maharashtra, India .
authors: Quazi Syed
authors: QS
authors: Zahiruddin
keywords: Energy balance; Ghrelin; Ghrelin O acyl transferase; Glucose metabolism; Obesity; Type 2 diabetes mellitusin