title: [Study on the relationship of platelet specific-autoantibodies with therapeutic outcomes by dexamethasone in immune thrombocytopenia purpura].
abstract: OBJECTIVE
  To investigate the different outcomes by dexamethasone in adults immune thrombocytopenia purpura (ITP) with different types of platelet specific-autoantibodies.
  
  
  METHODS
  A total of 185 ITP were enrolled, 61 males and 124 females, with a median age of 42 (18-83) years, including 117 newly diagnosed, 35 persistent, and 33 chronic cases. All the patients received the dexamethasone at an initial dose of 40 mg per day for 4 days and a low dose of 5-10 mg for 3-4 weeks. The platelet specific-autoantibodies were identified by the modified monoclonal antibody-specific immobilization of platelet antigen (MAIPA) assay.
  
  
  RESULTS
  Among the IgG positive patients, the response rates in anti-GPIIb/IIIa antibody, anti-GPIbα antibody, both antibody positive, and both antibody negative were 87.5%, 50.0%, 68.0%, and 72.3% (χ²=11.489, P<0.05), respectively. Among the IgM positive patients, the response rates in the four groups were 82.1%, 71.4%, 61.9%, and 68.9% (χ²=2.719, P=0.437), respectively. Among the GPIbα antibody positive patients, the response rates in IgG alone, IgM alone, both positive, and both negative were 52.4%, 59.1%, 76.1%, and 77.9% (χ²=10.811, P<0.05), respectively. Among the GPIIb/IIIa antibody positive patients, the response rates in the four groups were 73.3%, 71.0%, 78.6%, and 66.3% (χ²=1.374, P=0.719), respectively.
  
  
  CONCLUSIONS
  ITP patients with GPIbα-IgG antibody have worse response to dexamethasone treatment.
authors: Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors: Yang
authors: Y
authors: Chen
authors: Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors: Jian
authors: J
authors: Ge
authors: Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors: Min
authors: M
authors: Ruan
authors: Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors: Lingyan
authors: L
authors: Zhu
authors: Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors: Yanyan
authors: Y
authors: Xie
authors: Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors: Ruixiang
authors: R
authors: Xia
authors: Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors: Heyu
authors: H
authors: Ni
authors: Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors: Qingshu
authors: Q
authors: Zeng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D001792:Blood Platelets; D003907:Dexamethasone; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D016553:Purpura, Thrombocytopenic, Idiopathic; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D003907:Dexamethasone