title: The Accuracy of Single Photon Emission Computed Tomography/Computed Tomography Arthrography in Evaluating Aseptic Loosening of Hip and Knee Prostheses.
abstract: Aseptic loosening represents the most common complication associated with hip and knee arthroplasty and is a common indication for surgical revision in the post-arthroplasty population. The optimal imaging methodology in evaluating clinical suspected loosening is not well-defined. Our study retrospectively evaluated nuclear medicine arthrography with hybrid single photon emission computed tomography/computed tomography (SPECT/CT) in 38 patients (21 hip, 17 knee) compared with reference standards of surgical evaluation, spontaneous resolution of symptoms without revision, or a minimum of 1 year clinical and radiographic follow-up. Our study demonstrated a sensitivity of 100%, specificity of 96.0%, PPV of 92.9%, NPV of 100%, and accuracy of 97.4% with this imaging technique suggesting utility of nuclear medicine arthrography with SPECT/CT in the clinical evaluation of suspected aseptic loosening.
authors: Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
authors: Jonathan T
authors: JT
authors: Abele
authors: Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada.
authors: Vimarsha G
authors: VG
authors: Swami
authors: Division of Orthopedic Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
authors: Gordon
authors: G
authors: Russell
authors: Division of Orthopedic Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
authors: Edward C O
authors: EC
authors: Masson
authors: Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada.
authors: Jeffrey P
authors: JP
authors: Flemming
mesh_terms: D001175:Arthrography / Q000379:methods*; D019645:Arthroplasty, Replacement, Knee; D006801:Humans; D007719:Knee Joint; D007720:Knee Prosthesis; D011237:Predictive Value of Tests; D011475:Prosthesis Failure; D012086:Reoperation; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
keywords: SPECT/CT; arthrography; aseptic loosening; nuclear medicine; prosthesis