title: Unconventional actins and actin-binding proteins in human protozoan parasites.
abstract: Actin and its regulatory proteins play a key role in several essential cellular processes such as cell movement, intracellular trafficking and cytokinesis in most eukaryotes. While these proteins are highly conserved in higher eukaryotes, a number of unicellular eukaryotic organisms contain divergent forms of these proteins which have highly unusual biochemical and structural properties. Here, we review the biochemical and structural properties of these unconventional actins and their core binding proteins which are present in commonly occurring human protozoan parasites.
authors: Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India; Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City, Phase I, Bangalore 560100, India. Electronic address: cm44gupta@gmail.com.
authors: C M
authors: CM
authors: Gupta
authors: Institute of Bioinformatics and Applied Biotechnology, Biotech Park, Electronic City, Phase I, Bangalore 560100, India.
authors: S
authors: S
authors: Thiyagarajan
authors: Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
authors: A A
authors: AA
authors: Sahasrabuddhe
mesh_terms: D000199:Actins / Q000378:metabolism*; D056890:Eukaryota / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D011487:Protein Conformation; D011528:Protozoan Infections / Q000469:parasitology*
chemical_list: D000199:Actins
keywords: Actin-regulatory proteins; Parasite invasion; Protozoan parasites; Unconventional actins