title: The apolipoprotein B/apolipoprotein A-I ratio as a potential marker of plasma atherogenicity.
abstract: BACKGROUND
  The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting the presence or absence of cardiovascular disease, less is known about apoB/apoA-I ratio as a marker of plasma atherogenicity.
  
  
  METHODS
  A total of 157 normolipidemic men aged 20-59 years were included in the study. The plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apoA-I, apoB, and apoE were determined after a 12 h fasting period.
  
  
  RESULTS
  The median of the apoB/apoA-I ratio in the studied normolipidemic subjects was 0.52, with values ranging from 0.19 to 2.60. The percentage of subjects with the apoB/apoA-I ratio exceeding 0.9 (the accepted risk value of cardiovascular disease) was 19.1%. The subjects with apoB/apoA-I>0.9 were characterized by higher TG levels and atherogenic index of plasma (AIP) and lower values of ratio of low-density lipoprotein cholesterol (LDL-C) to apoB (LDL-C/apoB) and apoE levels compared with men with apoB/apoA-I<0.9.
  
  
  CONCLUSIONS
  Despite normolipidemia, the subjects with the unfavorable apoB/apoA-I ratio had more atherogenic lipid profile.
authors: Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences, Pervomaiskaya Avenue 50, Syktyvkar 167982, Russia.
authors: Anastasiya M
authors: AM
authors: Kaneva
authors: Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences, Pervomaiskaya Avenue 50, Syktyvkar 167982, Russia.
authors: Natalya N
authors: NN
authors: Potolitsyna
authors: Institute of Physiology, Komi Science Center, Ural Branch of Russian Academy of Sciences, Pervomaiskaya Avenue 50, Syktyvkar 167982, Russia.
authors: Evgeny R
authors: ER
authors: Bojko
authors: Faculty of Health Sciences, The Arctic University of Norway, 9037 Tromsø, Norway.
authors: Jon Ø
authors: JØ
authors: Odland
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D015415:Biomarkers; D014280:Triglycerides; D002784:Cholesterol