title: Prediction of HIV Virologic Failure Among Adolescents Using the Pediatric Symptom Checklist.
abstract: Psychosocial dysfunction is a risk factor for treatment non-adherence among children and adolescents. A previous study showed that high scores on the Pediatric Symptom Checklist (PSC) were associated with a history of HIV virologic failure. We assessed whether high scores on the PSC could predict virologic failure in HIV-infected youth. Caregivers of 234 adolescents between the ages of 10 and 16 years were asked to complete a PSC at baseline. Elevated PSC scores were associated with virologic failure in the subsequent 6 months. PSC scores may help guide resource utilization when viral load monitoring is limited.
authors: Departments of Pediatrics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. lowenthale@email.chop.edu.|Children's Hospital of Philadelphia, 3535 Market Street, Room 1513, Philadelphia, 19104, PA, USA. lowenthale@email.chop.edu.
authors: Elizabeth D
authors: ED
authors: Lowenthal
authors: Botswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
authors: Tafireyi
authors: T
authors: Marukutira
authors: Botswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
authors: Ontibile
authors: O
authors: Tshume
authors: Children's Hospital of Philadelphia, 3535 Market Street, Room 1513, Philadelphia, 19104, PA, USA.
authors: Jennifer
authors: J
authors: Chapman
authors: Botswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana.
authors: Gabriel M
authors: GM
authors: Anabwani
authors: Departments of Medicine (Infectious Diseases) and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors: Robert
authors: R
authors: Gross
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001902:Botswana / Q000453:epidemiology; D057189:Checklist; D002648:Child; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D008403:Mass Screening; D010372:Pediatrics; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D017211:Treatment Failure; D019562:Viral Load / Q000187:drug effects*
chemical_list: D019380:Anti-HIV Agents
keywords: Adolescents; HIV; Pediatric Symptom Checklist; Psychosocial dysfunction; Virologic failure