title: A new 3,4-seco-oleanane-type triterpenoid with an unusual enedione moiety from Hypericum ascyron.
abstract: A novel 3,4-seco-oleanane-type triterpenoid named 3,4-seco-olean-13(18)-ene-12,19-dione-3-oic acid (1), bearing an unusual enedione moiety, was isolated from the aerial parts of Hypericum ascyron, together with a known feiedelane-type triterpenoid friedelin (2). The structure of 1 with absolute configuration was elucidated on the basis of spectroscopic methods and a single-crystal X-ray diffraction analysis.
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors: Chunmei
authors: C
authors: Chen
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors: Guangzheng
authors: G
authors: Wei
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors: Hucheng
authors: H
authors: Zhu
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors: Yi
authors: Y
authors: Guo
authors: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
authors: Xiao-Nian
authors: XN
authors: Li
authors: Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors: Jinwen
authors: J
authors: Zhang
authors: The Central Hospital of Wuhan affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors: Yanfei
authors: Y
authors: Liu
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors: Guangmin
authors: G
authors: Yao
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors: Zengwei
authors: Z
authors: Luo
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: yongboxue@mail.hust.edu.cn.
authors: Yongbo
authors: Y
authors: Xue
authors: Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: zhangyh@mails.tjmu.edu.cn.
authors: Yonghui
authors: Y
authors: Zhang
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D012632:Secosteroids / Q000737:chemistry / Q000302:isolation & purification; D014315:Triterpenes / Q000302:isolation & purification; D000094042:Lupanes
chemical_list: D009828:Oleanolic Acid; D012632:Secosteroids; D014315:Triterpenes; C413246:oleanane; C060796:friedelin; D000094042:Lupanes
keywords: 3,4-seco-oleanane; Absolute configuration; Hypericum ascyron; Triterpenoid