title: Correlation between neuronal antibodies and limbic encephalitis in Chinese Han subjects.
abstract: A variety of anti-neuronal cell membrane antibodies such as voltage-gated potassium channel antibody, N-methyl-D-aspartate-2B-antibody, and glutamic acid decarboxylase antibody, are correlated with limbic encephalitis (LE). In this study on patients with LE, the clinical manifestations, psychology Wechsler Adult Intelligence Scale, cerebrospinal fluid, electrophysiology, magnetic resonance imaging, and anti-immune therapy were studied and immunological determination was conducted; it was found that patients of Chinese Han nationality showed 2 types of clinical manifestations: simple and complex. Lesions could also be divided into focal and scalable lesions, and the clinical manifestations and lesions scopes were associated with various antibodies and antibody types. The prognosis may improve if early diagnosis is conducted and early anti-immune therapy is implemented in LE patients.
authors: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China qimingchendoc@163.com.
authors: Q M
authors: QM
authors: Chen
authors: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
authors: H D
authors: HD
authors: Qu
authors: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
authors: W D
authors: WD
authors: Qian
authors: Scientific Research Center, Bengbu Medical College, Bengbu, China.
authors: L
authors: L
authors: Shen
authors: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
authors: L
authors: L
authors: Xu
authors: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
authors: Y H
authors: YH
authors: Chen
authors: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
authors: D Q
authors: DQ
authors: Sang
authors: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
authors: L N
authors: LN
authors: Zhang
authors: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
authors: L
authors: L
authors: Yin
authors: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
authors: L
authors: L
authors: Li
authors: Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
authors: H
authors: H
authors: Wang
mesh_terms: D000328:Adult; D044466:Asian People; D001323:Autoantibodies / Q000276:immunology*; D015153:Blotting, Western; D002681:China; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D020363:Limbic Encephalitis / Q000208:ethnology / Q000276:immunology* / Q000628:therapy; D008032:Limbic System / Q000276:immunology* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000276:immunology* / Q000378:metabolism; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology; D011379:Prognosis; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology; D014057:Tomography, X-Ray Computed; D014888:Wechsler Scales
chemical_list: D001323:Autoantibodies; D024642:Potassium Channels, Voltage-Gated; D016194:Receptors, N-Methyl-D-Aspartate; D005968:Glutamate Decarboxylase