title: [Hereditary diffuse gastric cancer].
abstract: Hereditary diffuse gastric cancer is an autosomal dominant syndrome associated to CDH1 gene mutation that affects at least 30% of CDH1+ families, with a penetrance of 80% at 80 years, and multifocal signed ring cell in most of the cases. The suggested treatment is a prophylactic total gastrectomy with Roux-en-Y esophagojejunostomy, malignancy sing must be imperative a gastrectomy.
authors: Hospital II Huamanga. Ayacucho, Perú.
authors: Xavier
authors: X
authors: Melo Pezo
authors: Servicio de Cirugía, Hospital Alberto Sabogal.
authors: Hector
authors: H
authors: Medrano Samamé
authors: Hospital II Huamanga. Ayacucho, Perú.
authors: Eliana
authors: E
authors: Torres Rosas
mesh_terms: D000359:Aftercare / Q000379:methods; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000235:genetics*; D015820:Cadherins / Q000235:genetics*; D018279:Carcinoma, Signet Ring Cell / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D009154:Mutation; D009386:Neoplastic Syndromes, Hereditary / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000601:surgery
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; D015820:Cadherins