title: Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges.
abstract: Crosstalk between angiogenesis and lymphangiogenesis in embryonic development continues during postnatal life and has specific mechanisms involving factors that initiate activation of the intracellular cascade for their specific receptors. Platelet-derived growth factors (PDGFs) and their corresponding receptors (PDGFRs) are known as important regulators of blood vessel development in both normal and pathologic angiogenesis. Despite some recent papers which reported a potential role of the PDGF/PDGFR axis in lymphatic spread of tumor cells, a few papers have suggested the potential role of PDGFs in tumor lymphangiogenesis development. The present paper summarizes the potential lymphangiogenic role of the PDGF/PDGFR axis, underlying upcoming challenges in the field.
authors: Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Andreea Adriana
authors: AA
authors: Jitariu
authors: Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Anca Maria
authors: AM
authors: Cimpean
authors: Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Nilima Rajpal
authors: NR
authors: Kundnani
authors: Victor Babes University of Medicine and Pharmacy, Timisoara, Romania.
authors: Marius
authors: M
authors: Raica
keywords: lymphangiogenesis; platelet-derived growth factor; platelet-derived growth factor receptor; tumor microenvironment