title: Y chromosome haplogroup D2a1 is significantly associated with high levels of luteinizing hormone in Japanese men.
abstract: The association between the Y chromosome haplogroup D2 and risk of azoospermia and low sperm motility has been previously studied, and it was indicated that haplogroups DE (YAP lineage) are associated with prostate cancer risk in Japanese males. Our assumption had been that Y chromosome haplogroups may be associated with sex hormone levels, because sex hormones have been deemed responsible for spermatogenesis and carcinogenesis. In this study, we assessed the association between Y chromosome haplogroups and sex hormone levels, including those of testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH), inhibin-B, and calculated free testosterone (cFT), in 901 young men from the general Japanese population (cohort 1) and 786 Japanese men of proven fertility (cohort 2). We found that the haplogroup D2a1 was significantly associated with high LH levels in a combined analysis involving two cohorts (β = 0.068, SE = 0.025, p = 0.0075), following correction for multiple testing. To date, this result is the first evidence that implicates Y chromosome haplogroups in an association with sex hormone levels.
authors: Department of Pharmaceutical Information Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.|Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors: Y
authors: Y
authors: Sato
authors: Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors: T
authors: T
authors: Shinka
authors: Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors: S
authors: S
authors: Nozawa
authors: Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors: M
authors: M
authors: Yoshiike
authors: Department of Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
authors: E
authors: E
authors: Koh
authors: Department of Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
authors: J
authors: J
authors: Kanaya
authors: Department of Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
authors: M
authors: M
authors: Namiki
authors: Department of Urology, Osaka Police Hospital, Osaka, Japan.
authors: K
authors: K
authors: Matsumiya
authors: Faculty of Medicine, Department of Urology, Graduate School of Medicine, Osaka University, Osaka, Japan.
authors: A
authors: A
authors: Tsujimura
authors: Department of Urology, Harasanshinkai Hospital, Fukuoka, Japan.
authors: K
authors: K
authors: Komatsu
authors: Department of Urology, Sapporo Medical University, Sapporo, Japan.
authors: N
authors: N
authors: Itoh
authors: Department of Urology, Nagasaki University, Nagasaki, Japan.
authors: J
authors: J
authors: Eguchi
authors: Department of Pharmaceutical Information Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors: A
authors: A
authors: Yamauchi
authors: Department of Urology, St. Marianna University School of Medicine, Kawasaki, Japan.|Center for Infertility and IVF, International University of Health and Welfare Hospital, Nasushiobara, Tochigi, Japan.
authors: T
authors: T
authors: Iwamoto
authors: Department of Human Genetics and Public Health, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors: Y
authors: Y
authors: Nakahori
mesh_terms: D000328:Adult; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005640:Follicle Stimulating Hormone / Q000097:blood; D005787:Gene Frequency / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007265:Inhibins / Q000097:blood; D007564:Japan; D007986:Luteinizing Hormone / Q000097:blood* / Q000235:genetics; D008297:Male; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D012738:Sex Hormone-Binding Globulin; C422364:inhibin B; D013739:Testosterone; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Japanese population; Y chromosome haplogroup; sex hormone