title: Assessment of bone vascularization and its role in bone remodeling.
abstract: Bone is a composite organ that fulfils several interconnected functions, which may conflict with each other in pathological conditions. Bone vascularization is at the interface between these functions. The roles of bone vascularization are better documented in bone development, growth and modeling than in bone remodeling. However, every bone remodeling unit is associated with a capillary in both cortical and trabecular envelopes. Here we summarize the most recent data on vessel involvement in bone remodeling, and we present the characteristics of bone vascularization. Finally, we describe the various techniques used for bone vessel imaging and quantitative assessment, including histology, immunohistochemistry, microtomography and intravital microscopy. Studying the role of vascularization in adult bone should provide benefits for the understanding and treatment of metabolic bone diseases.
authors: Laboratoire de Biologie Intégrée du Tissu Osseux, INSERM U 1059 , Saint-Etienne, France ; Université de Lyon , Lyon, France.
authors: Marie-Hélène
authors: MH
authors: Lafage-Proust
authors: Laboratoire de Biologie Intégrée du Tissu Osseux, INSERM U 1059 , Saint-Etienne, France ; Université de Lyon , Lyon, France.
authors: Bernard
authors: B
authors: Roche
authors: Université de Lyon , Lyon, France ; CREATIS, CNRS UMR 5220-INSERM U1044 , Lyon, France.
authors: Max
authors: M
authors: Langer
authors: Laboratoire de Biologie Intégrée du Tissu Osseux, INSERM U 1059 , Saint-Etienne, France ; Université de Lyon , Lyon, France.
authors: Damien
authors: D
authors: Cleret
authors: Laboratoire de Biologie Intégrée du Tissu Osseux, INSERM U 1059 , Saint-Etienne, France ; Université de Lyon , Lyon, France.
authors: Arnaud
authors: A
authors: Vanden Bossche
authors: Université de Lyon , Lyon, France ; Laboratoire Hubert Curien , Saint-Etienne, France.
authors: Thomas
authors: T
authors: Olivier
authors: Laboratoire de Biologie Intégrée du Tissu Osseux, INSERM U 1059 , Saint-Etienne, France ; Université de Lyon , Lyon, France.
authors: Laurence
authors: L
authors: Vico