title: Successful pregnancy and breastfeeding in a woman with mucopolysaccharidosis type I while receiving laronidase enzyme replacement. therapy.
abstract: The authors describe the first mother-infant pair to complete an on-going, prospective, open-label, Phase 4 trial (ALIU) UU3, NCT00418821) determining the safety of laronidase enzyme replacement therapy (ERT) in pregnant women with mucopolysaccharidosis type I (MPS I) and their breastfed infants. The mother, a 32-year-old with attenuated MPS I (Scheie syndrome), received laronidase for three years and continued treatment throughout her second pregnancy and while lactating. A healthy 2.5 kg male was delivered by elective cesarean section at 37 weeks. He was breastfed for three months. No laronidase was detected in breast milk. The infant never developed anti-laronidase IgM antibodies, never had inhibitory antibody activity in a cellular uptake assay, and always had normal urinary glycosaminoglycan (GAG) levels. No drug-related adverse events were reported. At 2.5 years of age, the boy is healthy with normal growth and development. In this first prospectively monitored mother-infant pair, laronidase during pregnancy and breastfeeding was uneventful.
authors: M
authors: M
authors: Castorina
authors: D
authors: D
authors: Antuzzi
authors: S M
authors: SM
authors: Richards
authors: G F
authors: GF
authors: Cox
authors: Y
authors: Y
authors: Xue
mesh_terms: D000328:Adult; D001942:Breast Feeding; D016903:Drug Monitoring / Q000379:methods; D056947:Enzyme Replacement Therapy / Q000379:methods; D005260:Female; D006025:Glycosaminoglycans / Q000652:urine; D006801:Humans; D007068:Iduronidase / Q000008:administration & dosage / Q000009:adverse effects; D007231:Infant, Newborn; D008297:Male; D008895:Milk, Human / Q000187:drug effects*; D015166:Monitoring, Immunologic; D008059:Mucopolysaccharidosis I / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D011256:Pregnancy Outcome; D011446:Prospective Studies
chemical_list: D006025:Glycosaminoglycans; D007068:Iduronidase