title: Prevalence of endometriosis in epithelial ovarian cancer. Analysis of the associated clinical features and study on molecular mechanisms involved in the possible causality.
abstract: OBJECTIVE
  To determine the prevalence of endometriosis in patients with epithelial ovarian cancer and explore the differences between women with endometrioid and clear-cell histologic subtypes with and without associated endometriosis.
  
  
  METHODS
  The medical charts of 496 patients with epithelial ovarian cancer at the Hospital Virgin de la Arrixaca (Murcia, Spain) between 1971 and 2010 were reviewed.
  
  
  RESULTS
  Endometriosis was present in 27 (5.4%) of the 496 cases (p < 0001), and was associated with the endometrioid histotype in 13/45 cases (29%) and with the clear cell histotype in 7/22 (32%). The prevalence of an association with endometriosis according to histologic type was 28.8% (13/45) for endometrioid carcinoma and 31.8% (7/22) for clear-cell carcinoma.
  
  
  CONCLUSIONS
  Both endometrioid and clear-cell ovarians tumours are associated with pelvic endometriosis. Patients with endometiosis associated ovarian cancer differ from non-endometiosis associated ovarian cancer in their clinical characteristics.
authors: F
authors: F
authors: Machado-Linde
authors: M L
authors: ML
authors: Sánchez-Ferrer
authors: P
authors: P
authors: Cascales
authors: A
authors: A
authors: Torroba
authors: R
authors: R
authors: Orozco
authors: Y
authors: Y
authors: Silva Sánchez
authors: A
authors: A
authors: Nieto
authors: G
authors: G
authors: Fiol
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000453:epidemiology* / Q000473:pathology; D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000453:epidemiology* / Q000473:pathology; D004715:Endometriosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D015995:Prevalence; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology