title: Frequency dependant topological alterations of intrinsic functional connectome in major depressive disorder.
abstract: Major depressive disorder is associated with aberrant topological organizations of brain networks. However, whether this aberrance is shown in broader frequency bands or in a specific frequency band remains unknown. Fifty patients and fifty gender, age and education matched normal controls underwent resting state functional magnetic resonance imaging. Frequency dependent topological measures based on graph theory were calculated from wavelet decomposed resting state functional brain signals. In the specific frequency band of 0.03-0.06 Hz, the clustering coefficient and the global efficiency were reduced while the characteristic path length was increased. Furthermore, patients showed aberrant nodal centralities in the default mode network, executive network and occipital network. Network based statistical analysis revealed system-wise topological alterations in these networks. The finding provides the first systematic evidence that depression is associated with frequency specific global and local topological disruptions and highlights the importance of frequency information in investigating major depressive disorders.
authors: 1] Department of psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China [2] Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China.
authors: Qinghua
authors: Q
authors: Luo
authors: 1] Key laboratory of cognition and personality (SWU), Ministry of Education, Chongqing 400715, China [2] Department of psychology, Southwest University, Chongqing 400715, China.
authors: Zhou
authors: Z
authors: Deng
authors: 1] Key laboratory of cognition and personality (SWU), Ministry of Education, Chongqing 400715, China [2] Department of psychology, Southwest University, Chongqing 400715, China.
authors: Jingxue
authors: J
authors: Qin
authors: 1] Key laboratory of cognition and personality (SWU), Ministry of Education, Chongqing 400715, China [2] Department of psychology, Southwest University, Chongqing 400715, China.
authors: Dongtao
authors: D
authors: Wei
authors: 1] Key laboratory of cognition and personality (SWU), Ministry of Education, Chongqing 400715, China [2] Department of psychology, Southwest University, Chongqing 400715, China.
authors: Lingli
authors: L
authors: Cun
authors: 1] Key laboratory of cognition and personality (SWU), Ministry of Education, Chongqing 400715, China [2] Department of psychology, Southwest University, Chongqing 400715, China.
authors: Jiang
authors: J
authors: Qiu
authors: 1] Key laboratory of cognition and personality (SWU), Ministry of Education, Chongqing 400715, China [2] Department of psychology, Southwest University, Chongqing 400715, China.
authors: Glen
authors: G
authors: Hitchman
authors: 1] Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China [2] Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China.
authors: Peng
authors: P
authors: Xie
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D019295:Computational Biology / Q000379:methods; D063132:Connectome; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012307:Risk Factors