title: Circulating Biomarkers Determining Inflammation in Atherosclerosis Progression.
abstract: Atherosclerosis is the main underlying pathology of cardiovascular disease and is precipitated by various hereditary and non-hereditary risk factors. Inflammation is considered an important step in the progression of atherosclerosis and involves numerous cells, mediators and cellular procedures. Therefore, a biomarker able to determine the vascular inflammatory status is imperative as the combination of inflammatory biomarkers with the classic risk factors might provide further information about atherosclerosis progression and cardiovascular risk. The identification of novel inflammatory molecules and the improvement in analytical methods allows the potential implementation of these tests in every day clinical practice. In the current article, we focus on the role of established and novel biomarkers in atherosclerosis progression and in the determination of cardiovascular risk. We also present recent data concerning the risk stratification of patients according to their inflammatory status and the possible anti-inflammatory treatment strategies.
authors: Vasilissis Sofias 114, TK 115 28, Hippokration Hospital, Athens, Greece. gsiasos@med.uoa.gr.
authors: Gerasimos
authors: G
authors: Siasos
authors: Vicky
authors: V
authors: Tsigkou
authors: Evangelos
authors: E
authors: Oikonomou
authors: Marina
authors: M
authors: Zaromitidou
authors: Sotiris
authors: S
authors: Tsalamandris
authors: Konstantinos
authors: K
authors: Mourouzis
authors: Manolis
authors: M
authors: Vavuranakis
authors: Maria
authors: M
authors: Anastasiou
authors: Konstantinos
authors: K
authors: Vlasis
authors: Maria
authors: M
authors: Limperi
authors: Vasiliki
authors: V
authors: Gennimata
authors: John N
authors: JN
authors: Boletis
authors: Athanasios G
authors: AG
authors: Papavassiliou
authors: Dimitris
authors: D
authors: Tousoulis
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use; D050197:Atherosclerosis / Q000097:blood* / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D015444:Exercise; D006801:Humans; D007249:Inflammation / Q000097:blood; D007378:Interleukins / Q000097:blood; D012307:Risk Factors
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D007378:Interleukins; D002097:C-Reactive Protein