title: Meta-analysis of the association between the rs8034191 polymorphism in AGPHD1 and lung cancer risk.
abstract: BACKGROUND
  Possible associations between the single nucleotide polymorphism (SNP) rs8034191 in the aminoglycosidephosphotransferase domain containing 1 (AGPHD1) gene and lung cancer risk have been studied by many researchers but the results have been contradictory.
  
  
  METHODS
  A computerized search for publications on rs8034191 and lung cancer risk was performed. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between rs8034191 and lung cancer risk with 13 selected case-control studies. Sensitivity analysis, test of heterogeneity, cumulative meta-analysis, and assessment of bias were also performed.
  
  
  RESULTS
  A significant association between rs8034191 and lung cancer susceptibility was found using the dominant genetic model (OR=1.344, 95% CI: 1.285-1.406), the additive genetic model (OR=1.613, 95% CI: 1.503-1.730), and the recessive genetic model (OR=1.408, 95% CI: 1.319-1.503). Moreover, an increased lung cancer risk was found with all genetic models after stratification of ethnicity.
  
  
  CONCLUSIONS
  The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer. Further functional studies of this polymorphism and lung cancer risk are warranted.
authors: School of Life Sciences, Northwest University, Xi'an, China E-mail : cchen898@nwu.edu.cn.
authors: Le
authors: L
authors: Zhang
authors: Tian-Bo
authors: TB
authors: Jin
authors: Ya
authors: Y
authors: Gao
authors: Hui-Juan
authors: HJ
authors: Wang
authors: Hua
authors: H
authors: Yang
authors: Tian
authors: T
authors: Feng
authors: Chen
authors: C
authors: Chen
authors: Long-Li
authors: LL
authors: Kang
authors: Chao
authors: C
authors: Chen
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D010430:Pentosyltransferases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors
chemical_list: D010430:Pentosyltransferases; C082048:aminoglycoside phosphoribosyltransferase