title: Cobalt(II) catalyzed C(sp)-H bond functionalization of alkynes with phenyl hydrazines: facile access to diaryl 1,2-diketones.
abstract: A cobalt acetylacetonate catalyzed oxidative diketonation of alkynes via C(sp)-H bond functionalization has been described. The reaction involves a free-radical mechanism, wherein the phenyl radical formed from phenyl hydrazine couples with Co(II) activated alkyne to produce 1,2-diketones. The reaction proceeds at room temperature in DMF with the use of Ag2O/air as the oxidizing system. The utility of the protocol for the synthesis of a series of imidazoles including a potent platelet aggregation inhibitor trifenagrel has been demonstrated.
authors: Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India. sbharate@iiim.ac.in ram@iiim.ac.in.
authors: Jaideep B
authors: JB
authors: Bharate
authors: Sheenu
authors: S
authors: Abbat
authors: Rohit
authors: R
authors: Sharma
authors: Prasad V
authors: PV
authors: Bharatam
authors: Ram A
authors: RA
authors: Vishwakarma
authors: Sandip B
authors: SB
authors: Bharate
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D006834:Hydrazines / Q000737:chemistry*; D006860:Hydrogen Bonding; D007659:Ketones / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006834:Hydrazines; D007659:Ketones; D003035:Cobalt