title: [Sensitivity and specificity of the cerebral blood flow reactions to acupuncture in the newborn infants presenting with hypoxic ischemic encephalopathy].
abstract: OBJECTIVE
  To evaluate the effects of acupuncture integrated into the standard therapy, the condition of cerebral blood flow, and other syndromes associated with cerebral ischemia in the newborn infants. MATERIAL AND METHODS. A total of 131 pairs of puerperae and newborns with hypoxic ischemic encephalopathy were divided into four treatment groups. 34 children of the first group were given standard therapy (control), in the second group comprised of 33 mothers and children the standard treatment was supplemented by acupuncture, the third group included only 32 mothers given the acupuncture treatment alone, and the fourth group contained only 32 newborn infants treated by acupuncture. Each course of acupuncture treatment consisted of five sessions. Sensitivity and specificity of cerebral blood flow reactions were determined based on the results of the ROC-analysis and the area under the curve before and after the treatment.
  
  
  RESULTS
  The treatment with the use of acupuncture greatly improved the cerebrospinal hemodynamics (p < 0.05). Other symptoms, viz. sleep disorders, vegetative reactivity and excitability were significantly reduced. The ROC analysis confirmed the effectiveness of acupuncture as a tool for the treatment of the impaired cerebral blood flow in the newborn babies. The high level of sensitivity (84.4-94.8%) associated with good specificity makes it possible to distinguish between the true positive and true negative cases.
  
  
  CONCLUSIONS
  Acupuncture integrated into the treatment of "mother-baby" pairs presenting with hypoxic ischemic encephalopathy can be used to improve the initially low level of cerebral blood flow in neonates presenting with this condition.
authors: Federal state budgetary educational institution of higher professional education 'I.N. Ul'yanov Chuvash State University', Russian Ministry of Education and Science, Cheboksary.
authors: A V
authors: AV
authors: Filonenko
authors: Federal state budgetary institution 'Russian Research Centre of Medical Rehabilitation and Balneotherapeutics', Russian Ministry of Health, Moscow.
authors: A M
authors: AM
authors: Vasilenko
authors: Federal state budgetary institution 'Russian Research Centre of Medical Rehabilitation and Balneotherapeutics', Russian Ministry of Health, Moscow.
authors: M A
authors: MA
authors: Khan
mesh_terms: D015670:Acupuncture Therapy; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology* / Q000628:therapy*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000503:physiopathology* / Q000628:therapy*; D008297:Male