title: Changes in cerebral blood flow in children with sickle cell disease after splenectomy.
abstract: The study assessed changes in cerebral blood flow and need for chronic blood transfusions in sickle cell disease children after splenectomy. A retrospective chart review of 40 children splenectomized between 1999 and 2014 was performed. The mean time-average maximum velocity before splenectomy was 129 cm/sec; which increased to 157 cm/sec and then decreased to 137 cm/sec, 2 and 5 years postsplenectomy, respectively. There was a persistent and statistically significant elevation in platelet count noted after splenectomy. The mean cerebral blood flow velocity seemed to increase transiently after splenectomy. Close monitoring and screening for stroke risk should be continued postsplenectomy.
authors: University of South Alabama, Children's and Women's Hospital, Department of Pediatrics, Division of Hematology/Oncology , Alabama , USA.
authors: Abdul Hafeez
authors: AH
authors: Siddiqui
authors: Peter B
authors: PB
authors: Soh
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000503:physiopathology* / Q000601:surgery*; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013156:Splenectomy
keywords: hematology; hemoglobinopathies; pediatrics; sickle cell disease; surgery