title: Benefits of plasma rich in growth factors (PRGF) in skin photodamage: clinical response and histological assessment.
abstract: Skin ageing is characterized by small and fine wrinkles, roughness, laxity, and pigmentation as a result of epidermal thinning, collagen degradation, dermal atrophy, and fewer fibroblasts. Plasma rich in growth factors (PRGF) is an autologous plasma preparation enriched in proteins obtained from patient's own blood aimed at accelerating tissue repair and regeneration. To evaluate the benefits of PRGF in skin photodamage, 10 healthy volunteers were treated with three consecutive intradermal injections of PRGF in the facial area. Clinical outcomes and histological analysis were performed. A statistically significant increase in the epidermis and papillary dermis thickness was seen after PRGF treatment (p < 0.001). Skin thickening was observed in all patients studied, being more intense in the group of patients with photodamage (p < 0.001). After PRGF treatment, a reduction of the average area fraction of solar elastosis was observed in patients with clinical and histological signs of skin photodamage (p < 0.05).No changeswere observed in the number of CD31, XIIIa factor, cKit, CD10, nor p53-positive cells. The improvement score after PRGF use was 0.75 (9/12) for the group of patients with signs of skin photodamage. Intradermal PRGF infiltration appears to be an effective treatment for the photodamaged skin.
authors: Dermatology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors: B
authors: B
authors: Díaz-Ley
authors: Pathology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors: J
authors: J
authors: Cuevast
authors: Dermatology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors: L
authors: L
authors: Alonso-Castro
authors: Research Foundation, Hospital Ramón y Cajal, Madrid, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors: M I
authors: MI
authors: Calvo
authors: Dermatology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors: L
authors: L
authors: Ríos-Buceta
authors: Foundation Eduardo Anitua, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors: G
authors: G
authors: Orive
authors: Foundation Eduardo Anitua, Hospital Universitario de Guadalajara, Guadalajara, Spain.|BTI Biotechnology Institute, Vitoria, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors: E
authors: E
authors: Anitua
authors: Dermatology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain.
authors: P
authors: P
authors: Jaén
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques; D020405:Dermis / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D005145:Face; D005260:Female; D006801:Humans; D007271:Injections, Intradermal; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D053657:Platelet-Rich Plasma; D012060:Rejuvenation; D015595:Skin Aging / Q000187:drug effects* / Q000473:pathology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins
keywords: PRGF; clinical assessment; growth factors; histology; platelet-rich plasma; skin photodamage