title: Stromal cells in chronic inflammation and tertiary lymphoid organ formation.
abstract: Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflammatory cells within inflamed tissues. Furthermore, at many sites of chronic inflammation, structures that mimic secondary lymphoid tissues are observed, suggesting that chronic inflammation and lymphoid tissue formation share common activation programs. Similarly, blood and lymphatic endothelial cells contribute to tissue homeostasis and disease persistence in chronic inflammation. This review highlights our increasing understanding of the role of stromal cells in inflammation and summarizes the novel immunological role that stromal cells exert in the persistence of inflammatory diseases.
authors: Rheumatology Research Group, Center for Translational Inflammation Research, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham B15 2WD, United Kingdom.
authors: Christopher D
authors: CD
authors: Buckley
authors: Francesca
authors: F
authors: Barone
authors: Saba
authors: S
authors: Nayar
authors: Cecile
authors: C
authors: Bénézech
authors: Jorge
authors: J
authors: Caamaño
mesh_terms: D000818:Animals; D002450:Cell Communication; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D008221:Lymphoid Tissue / Q000276:immunology* / Q000378:metabolism*; D038081:Organogenesis / Q000276:immunology; D010641:Phenotype; D017154:Stromal Cells / Q000276:immunology* / Q000378:metabolism*
keywords: chronic inflammation; fibroblast; persistence; stromal cells