title: G-quadruplex ligands exhibit differential G-tetrad selectivity.
abstract: A rapid and simple equilibrium-binding assay mediated by ligand-induced fluorescence quenching of fluorophore-labelled G-quadruplex (G4) structures enabled quantitative interrogation of mutually exclusive ligand binding interactions at opposed G-tetrads. This technique revealed that the ligands TmPyP4, PhenDC3, and PDS have differential chemotype-specific binding preferences for individual G-tetrads of a model genomic G4 structure.
authors: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
authors: D D
authors: DD
authors: Le
authors: M
authors: M
authors: Di Antonio
authors: L K M
authors: LK
authors: Chan
authors: S
authors: S
authors: Balasubramanian
mesh_terms: D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D013379:Substrate Specificity
chemical_list: D005456:Fluorescent Dyes; D008024:Ligands