title: Control of gene expression by novel metabolic intermediates.
abstract: In view of the recent discoveries of novel nuclear receptors (NRs) whose ligands remain to be determined, metabolic intermediates may be considered as ligands for these receptors and undiscovered or overlooked intermediates may play important roles in regulating gene expression by activating or repressing the action of these nuclear receptors. This article is part of a Special Issue entitled 'Steroid Perspectives'.
authors: Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX, USA. Electronic address: jgustafsson@uh.edu.
authors: Jan-Ake
authors: JA
authors: Gustafsson
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D013256:Steroids / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D004967:Estrogens; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D013256:Steroids; D005947:Glucose
keywords: Bile acid; Ligand; Nuclear receptor; Oxysterol; Steroid