title: Serotonin and the bone assessment.
abstract: BACKGROUND
  Lately, the in vitro and in vivo studies on serotonin metabolism have been pointing its influence in bone health. Also, there are no particular recommendations in performing the serum serotonin assessment in order to evaluate the skeletal status.
  
  
  OBJECTIVE
  We aimed to correlate the bone turnover markers and lumbar bone mineral density (BMD) with serotonin.
  
  
  METHODS
  There is a cross-sectional study in Caucasian postmenopausal women. They were not diagnosed with carcinoid syndrome, or bone anomalies, and received no treatment (including antiresorptives). The following bone formation markers were performed: serum alkaline phosphatase (AP), serum osteocalcin (OC), and the bone resorption marker: serum CrossLaps (CL). Serum serotonin (high-pressure liquid chromatography), as well as central DXA (GE Prodigy) were assessed.
  
  
  RESULTS
  191 women of 57.1 years mean age were grouped according to DXA (WHO criteria). The linear regression analysis between serum serotonin and CL were not statistically significant (SS), between serotonin and OC was SS in the newly diagnosed osteoporosis group (N=40, r=0.4, p=0.03), between serotonin and AP SS was found in osteopenia group (N=88, r=0.24, p=0.03), with no changes when adjusting for age and BMI. The partial correlation between serotonin and BMD was not SS.
  
  
  CONCLUSIONS
  The study raises the question of serotonin as a bone metabolism marker seeing that the results were not consistent. The main limit of our study was that we did not analyze the possible use of antidepressants to these women. Overall, this was a pilot study in clinical practice where few reports have been published, but still necessary, because the use of serum serotonin in current skeletal evaluation is still unclear.
authors: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors: M
authors: M
authors: Carsote
authors: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors: V
authors: V
authors: Radoi
authors: "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors: A
authors: A
authors: Geleriu
authors: "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors: A
authors: A
authors: Mihai
authors: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors: D
authors: D
authors: Ferechide
authors: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors: D
authors: D
authors: Opris
authors: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors: D
authors: D
authors: Paun
authors: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania ; "C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
authors: C
authors: C
authors: Poiana
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D003094:Collagen / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010865:Pilot Projects; D012701:Serotonin / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; D015675:Osteocalcin; D012701:Serotonin; D003094:Collagen
keywords: Alkaline Phosphatase; CrossLaps; Osteocalcin; osteoporosis; serotonin