title: Suspected autoimmune hepatitis and primary biliary cirrhosis unmasked by interferon-beta in a multiple sclerosis patient.
abstract: The use of interferon-beta in multiple sclerosis is associated with various forms of hepatotoxicity, including autoimmune hepatitis and liver failure. We describe a case with features of autoimmune liver disease and primary biliary cirrhosis occurring during long-term treatment with interferon-beta in a patient with relapsing-remitting multiple sclerosis. This case highlights the importance of monitoring biochemical liver test results throughout interferon-beta treatment of multiple sclerosis.
authors: Neuroscience Program, University of British Columbia (UBC), Vancouver, Canada; Child & Family Research Institute, Vancouver, Canada; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, Canada.
authors: Kaarina
authors: K
authors: Kowalec
authors: Division of Gastroenterology, UBC, Vancouver, Canada.
authors: Eric M
authors: EM
authors: Yoshida
authors: Division of Neurology, UBC, Vancouver, Canada.
authors: Anthony
authors: A
authors: Traboulsee
authors: Child & Family Research Institute, Vancouver, Canada; Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, Canada; Division of Translational Therapeutics, Department of Pediatrics, UBC, Vancouver, Canada.
authors: Bruce
authors: B
authors: Carleton
authors: Neuroscience Program, University of British Columbia (UBC), Vancouver, Canada; Division of Neurology, UBC, Vancouver, Canada. Electronic address: helen.tremlett@ubc.ca.
authors: Helen
authors: H
authors: Tremlett
keywords: Autoimmune hepatitis; Drug safety; Interferon-beta; Liver injury; Multiple sclerosis; Primary biliary cirrhosis