title: IL-35 over-expression is associated with genesis of gastric cancer.
abstract: Overexpression of interleukin (IL)-35 has been found in a variety of malignancies, but the expression status in gastric cancer has yet to be elucidated clearly. In the present study, positive expression of EBI3 and p35 was 63.3% and 70.0% of cases, respectively. EBI3 expression was strongly related with larger tumor size and invasion depth (P<0.05). Similarly, expression of p35 was also correlated with larger tumor size (P<0.05). These results indicate that IL-35 might be involved in growth of gastric cancer. Interestingly, EBI3 and p35 expressions were positive correlated with Ki-67 expression. Moreover, EBI3 immunoreactivity was associated with Bcl-2 staining. Our data suggest IL-35 is correlated with genesis of gastric cancer by regulating growth and apoptosis.
authors: Departments of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China E-mail : zengchaosysu@aliyun.com.
authors: Yong-Gang
authors: YG
authors: Fan
authors: Jing-Ming
authors: JM
authors: Zhai
authors: Wei
authors: W
authors: Wang
authors: Bing
authors: B
authors: Feng
authors: Guo-Liang
authors: GL
authors: Yao
authors: Yan-Hui
authors: YH
authors: An
authors: Chao
authors: C
authors: Zeng
mesh_terms: D000368:Aged; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism*; D049109:Cell Proliferation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007378:Interleukins / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*; D046888:Tissue Array Analysis; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; D007378:Interleukins; C532417:interleukin-35, human