title: TTF-1 and napsin A on cell blocks and supernatants of pleural fluids for labeling malignant effusions.
abstract: In this retrospective study of 80 pleural effusions, the combination of thyroid transcription factor 1 (TTF-1) and napsin A immunostaining on fluid cell blocks was positive in 80% of lung adenocarcinomas. Although measuring TTF-1 pleural fluid concentrations was of no value, quantification of napsin A levels allowed the identification of one third of the double-negative stained lung adenocarcinomas, with an overall accuracy similar to classical tumour markers for malignant-benign discrimination (sensitivity 40%, specificity 100%).
authors: Pleural Medicine Unit, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain.
authors: José M
authors: JM
authors: Porcel
authors: Pleural Medicine Unit, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain.
authors: Rosa
authors: R
authors: Palma
authors: Pleural Medicine Unit, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain.
authors: Silvia
authors: S
authors: Bielsa
authors: Department of Laboratory Medicine, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain.
authors: Aureli
authors: A
authors: Esquerda
authors: Department of Pathology, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain.
authors: Sonia
authors: S
authors: Gatius
authors: Department of Pathology, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain.
authors: Xavier
authors: X
authors: Matias-Guiu
authors: Department of Medical Oncology, Arnau de Vilanova University Hospital, Biomedical Research Institute of Lleida, Lleida, Spain.
authors: Antonieta
authors: A
authors: Salud
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology; D000077192:Adenocarcinoma of Lung; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology; D008297:Male; D009687:Nuclear Proteins / Q000378:metabolism*; D016066:Pleural Effusion, Malignant / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D016282:Aspartic Acid Endopeptidases; C498549:NAPSA protein, human
keywords: TTF-1; lung cancer; napsin A; pleural effusion