title: Asymmetric Michael addition reactions of nitroalkanes to 2-furanones catalyzed by bifunctional thiourea catalysts.
abstract: The first bifunctional thiourea catalyzed asymmetric Michael addition reactions of nitroalkanes to 2-furanones are described. The highly functionalized γ-lactones with two or three consecutive stereogenic carbons were obtained in high yields (up to 99%), high diastereoselectivities (up to >20 : 1 dr) and enantioselectivities (up to >99% ee).
authors: State Key Laboratory of Nature and Biomimtic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. xinwang@bjmu.edu.cn lirt@bjmu.edu.cn.
authors: Zhushuang
authors: Z
authors: Bai
authors: Ling
authors: L
authors: Ji
authors: Zemei
authors: Z
authors: Ge
authors: Xin
authors: X
authors: Wang
authors: Runtao
authors: R
authors: Li
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D002384:Catalysis; D055598:Chemical Phenomena; D002851:Chromatography, High Pressure Liquid; D005663:Furans / Q000737:chemistry*; D008968:Molecular Conformation; D009574:Nitro Compounds / Q000737:chemistry*; D013890:Thiourea / Q000737:chemistry*; D014965:X-Rays
chemical_list: D000473:Alkanes; D005663:Furans; D009574:Nitro Compounds; D013890:Thiourea