title: Effect of posterior vitreous detachment on aqueous humor level of vascular endothelial growth factor in exudative age-related macular degeneration patients.
abstract: BACKGROUND
  To investigate the association of posterior vitreous detachment (PVD) with aqueous levels of vascular endothelial growth factor (VEGF) in eyes with exudative age-related macular degeneration (AMD).
  
  
  METHODS
  This is a prospective comparative study. Subjects are 33 eyes with exudative AMD. PVD was examined by B-mode ultrasonography and the subjects were divided into a complete PVD group (PVD group) or a group with partial or no PVD (without PVD group). At the beginning of intravitreal injection of ranibizumab, aqueous humor was collected and the concentration of VEGF was measured using ELISA. The concentration was compared between the two groups.
  
  
  RESULTS
  Complete PVD was observed in 13 (39 %) eyes. The mean concentration of VEGF was 58 pg/ml in the PVD group and 91 pg/ml in the without PVD group. Multiple regression analysis revealed that the concentration of VEGF was significantly lower in the eyes with PVD than in those without PVD independent of age and sex (P = 0.02).
  
  
  CONCLUSIONS
  Complete PVD is related to the lower concentration of aqueous VEDF in AMD eyes.
authors: Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. nomurayoko-tky@umin.ac.jp.
authors: Yoko
authors: Y
authors: Nomura
authors: Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.|Department of Ophthalmology, Jichi Medical University, Tochigi, Japan.
authors: Hidenori
authors: H
authors: Takahashi
authors: Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors: Xue
authors: X
authors: Tan
authors: Department of Ophthalmology, Japan Community Health care Organization Tokyo Shinjuku Medical Center, Tokyo, Japan.
authors: Yujiro
authors: Y
authors: Fujino
authors: Department of Ophthalmology, Jichi Medical University, Tochigi, Japan.
authors: Hidetoshi
authors: H
authors: Kawashima
authors: Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. yanagi-tky@umin.ac.jp.
authors: Yasuo
authors: Y
authors: Yanagi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D000069579:Ranibizumab / Q000627:therapeutic use*; D041623:Tomography, Optical Coherence; D014463:Ultrasonography; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014792:Visual Acuity / Q000502:physiology; D020255:Vitreous Detachment / Q000000981:diagnostic imaging / Q000378:metabolism*; D057135:Wet Macular Degeneration / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000069579:Ranibizumab
keywords: Age-related macular degeneration; Aqueous humor; Posterior vitreous detachment; Vascular endothelial growth factor