title: Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent.
abstract: GPR37, also known as parkin associated endothelin-like receptor (Pael-R), is an orphan GPCR that aggregates intracellularly in a juvenile form of Parkinson's disease. However, little is known about the function of this orphan receptor. Here, using a model for parkisonian tremor, the pilocarpine-induced tremulous jaw movements (TJMs), we show that the deletion of GPR37 attenuated the TJMs in response to this cholinomimetic. Interestingly, the control that adenosine A2A receptor exerted over TJMs was lost in the absence of GPR37, thus pointing to a pivotal role of this orphan receptor in the adenosinergic control of parkinsonian tremor.
authors: Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
authors: Jorge
authors: J
authors: Gandía
authors: Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
authors: Xavier
authors: X
authors: Morató
authors: Department of Biochemistry, Donnelly Centre, University of Toronto, Toronto, Ontario, Canada; Department of Molecular Genetics, Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
authors: Igor
authors: I
authors: Stagljar
authors: Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain. Electronic address: vfernandez@ub.edu.
authors: Víctor
authors: V
authors: Fernández-Dueñas
authors: Unitat de Farmacologia, Departament de Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, 08907 Barcelona, Spain; Department of Physiology, Faculty of Sciences, University of Ghent, 9000 Gent, Belgium. Electronic address: fciruela@ub.edu.
authors: Francisco
authors: F
authors: Ciruela
mesh_terms: D058917:Adenosine A2 Receptor Antagonists / Q000494:pharmacology; D000818:Animals; D007568:Jaw / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009068:Movement / Q000187:drug effects / Q000502:physiology; D018727:Muscarinic Antagonists / Q000494:pharmacology; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000503:physiopathology*; D010862:Pilocarpine; D011743:Pyrimidines / Q000494:pharmacology; D043705:Receptor, Adenosine A2A / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D014202:Tremor / Q000188:drug therapy / Q000503:physiopathology*; D014230:Triazoles / Q000494:pharmacology; D014331:Tropicamide / Q000494:pharmacology
chemical_list: C098657:5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine; D058917:Adenosine A2 Receptor Antagonists; C509804:Gpr37 protein, mouse; D018727:Muscarinic Antagonists; D011743:Pyrimidines; D043705:Receptor, Adenosine A2A; D043562:Receptors, G-Protein-Coupled; D014230:Triazoles; D010862:Pilocarpine; D014331:Tropicamide
keywords: GPR37; Orphan receptor; Pael-R; Parkinson's disease; Tremulous jaw movement