title: A Trial of Rectal Indomethacin to Prevent Post-ERCP Pancreatitis in Patients with Suspected Type 3 Sphincter of Oddi Dysfunction.
abstract: OBJECTIVE
  Recent data have suggested that rectal indomethacin can also reduce the incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP). The aim of this study was to determine whether prophylactic rectal indomethacin with PD stenting would reduce the incidence and severity of PEP compared to PD stenting alone in patients undergoing manometry for suspected SOD type 3.
  
  
  METHODS
  A retrospective review of consecutive patients who underwent an ERCP with manometry for suspected SOD type 3 was performed. Patients were divided into two groups: (a) those who received a prophylactic PD stent (n = 285) and (b) those who received a prophylactic PD stent and a single dose of 100-mg indomethacin suppositories after ERCP (n = 57). The rate of PEP was compared between the two groups.
  
  
  RESULTS
  The two patient groups were similar with regard to patient and procedure risk factors for PEP. Post-ERCP pancreatitis developed in 22 % patients. There was no significant difference in the incidence of PEP in the PD stent group compared to the PD stent and indomethacin group (23 vs. 18 %, respectively; p = 0.39). Moderate-to-severe pancreatitis developed in 21 (7 %) patients in the PD stent group compared to 5 (9 %) patients in the PD stent and indomethacin group (p = 0.78). Among patients with PEP, the median length of hospital stay was not significantly longer in the PD stent group compared to the PD stent and indomethacin group (6 vs. 4 days, respectively; p = 0.11).
  
  
  CONCLUSIONS
  In patients with suspected SOD type 3, prophylactic rectally administered indomethacin with PD stenting was not observed to affect the incidence or severity of post-ERCP pancreatitis when compared to PD stenting alone.
authors: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA, Ali.Siddiqui@Jefferson.edu.
authors: Ali A
authors: AA
authors: Siddiqui
authors: Devi
authors: D
authors: Patel
authors: Jeremy
authors: J
authors: Kaplan
authors: Andrew H
authors: AH
authors: Zabolotsky
authors: David
authors: D
authors: Loren
authors: Thomas
authors: T
authors: Kowalski
authors: Saad S
authors: SS
authors: Ghumman
authors: Douglas G
authors: DG
authors: Adler
authors: Satish
authors: S
authors: Munigal
authors: Umar
authors: U
authors: Hayat
authors: Mohamad A
authors: MA
authors: Eloubeidi
mesh_terms: D000285:Administration, Rectal; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015994:Incidence; D007213:Indomethacin / Q000008:administration & dosage*; D007902:Length of Stay; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010195:Pancreatitis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies; D012307:Risk Factors; D046628:Sphincter of Oddi Dysfunction / Q000145:classification / Q000175:diagnosis*; D015607:Stents
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin