title: [Bone mineral metabolism in patients with chronic kidney disease on dialysis in Southern Metropolitan Santiago].
abstract: BACKGROUND
  Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a condition of dialysis patients associated with both morbidity and mortality. Management is based on clinical guidelines with goals that are hard to comply with.
  
  
  OBJECTIVE
  To describe and compare biochemical variables associated with this disorder in two different time periods.
  
  
  METHODS
  Revision of medical records of 814 patients (49% females) dialyzed during 2009 and 1018 patients (48% females), dialyzed during 2012 in Southern Metropolitan Santiago. Information about serum calcium, phosphorus, parathyroid hormone (PTH) and albumin was retrieved.
  
  
  RESULTS
  Median PTH values in 2009 and 2012 were 222.5 and 353.5 pg/ml respectively (p < 0.05). The figures for serum calcium corrected by albumin were 9.0 and 8.5 mg/dl respectively (p < 0.05). The figures for phosphorus were 4.7 and 5.0 mg/dl respectively (p < 0.05). The Calcium x Phosphorus product was 41.4 and 42.5 mg²/dl² (p < 0.05). Of note, the proportion patients with serum calcium below recommended levels (< 8.4 mg/dl) increased from 16% to 40% from 2009 to 2012. The proportion of patients with biochemical variables within recommended ranges was lower in 2012 than in 2009.
  
  
  CONCLUSIONS
  There was a low proportion of patients with bone metabolism parameters within ranges recommended by clinical guidelines. These parameters were worst in 2012.
authors: Andrea
authors: A
authors: Ruiz de Arechavaleta
authors: Nerio
authors: N
authors: Quintero
authors: Daniela
authors: D
authors: Parra E U
authors: Aquiles
authors: A
authors: Jara
authors: Moisés
authors: M
authors: Russo
authors: Pedro
authors: P
authors: Zitko
authors: Jacqueline
authors: J
authors: Pefaur
mesh_terms: D000368:Aged; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D002677:Chile; D015331:Cohort Studies; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects; D051436:Renal Insufficiency, Chronic / Q000378:metabolism*; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D013997:Time Factors
chemical_list: D010281:Parathyroid Hormone; D012709:Serum Albumin; D010758:Phosphorus; D002118:Calcium