title: Can platelet indices be used as predictors of complication in subjects with appendicitis?
abstract: BACKGROUND
  We examined the changes of mean platelet volume (MPV) and platelet distribution width (PDW) in subjects with appendicitis and whether MPV and PDW could be used to predict the development of complication due to appendicitis.
  
  
  METHODS
  The healthy control group, the cases of appendicitis with perforation, and the cases of appendicitis without perforation were compared with regard to MPV and PDW. We determined whether MPV and PDW were independent variables predictive of the development of complication in subjects with appendicitis.
  
  
  RESULTS
  This retrospective case-control study included a total of 362 patients (249 of which were male (68.8 %) and 113 were female (31.2 %); median age, 30 [range, 18-84 years]). One hundred and ninety-two subjects (53 %) presented with appendicitis and 170 (47 %) comprised the healthy control group. Sixty-six (18.2 %) of the subjects with appendicitis developed complication. MPVs were lower in subjects of appendicitis without complication compared to the subjects of appendicitis with complication and the control group (MPV, 9.78 ± 0.99 vs. 10.20 ± 1.21 and 10.14 ± 1.03, respectively [p = 0.005]). The PDW levels were not different between the three groups. Independent variables predictive of the presence of complication included increased MPV and time from onset of symptoms to hospital presentation (odds ratio[confidence interval], p-value: 1.507[1.064-2.133], 0.021 and 18.887[5.139-69.410], 0.0001, respectively).
  
  
  CONCLUSIONS
  Our findings suggested these, MPV values in cases of appendicitis without complication were lower than the cases with complication and healthy control and MPV is a predictor of the development of complication in subjects with appendicitis.
authors: Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakıf University, Vatan Caddesi, Fatih, İstanbul, Turkey. bceylan2004@yahoo.com.|, Yıldırım Beyazıt Caddesi, Zafer Mahallesi, Bosnapark Evleri, No: 8, Daire 13, Kat 3, Yenibosna, Bahçelievler, Istanbul, Turkey. bceylan2004@yahoo.com.
authors: Bahadır
authors: B
authors: Ceylan
authors: Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakıf University, Vatan Caddesi, Fatih, İstanbul, Turkey.
authors: Turan
authors: T
authors: Aslan
authors: Medical Faculty, Department of Internal Diseases, Bezmialem Vakıf University, Vatan Caddesi, Fatih, İstanbul, Turkey.
authors: Ahmet
authors: A
authors: Çınar
authors: Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakıf University, Vatan Caddesi, Fatih, İstanbul, Turkey.
authors: Ayşe
authors: A
authors: Ruhkar Kurt
authors: Medical Faculty, Department of Infectious Diseases and Clinical Microbiology, Bezmialem Vakıf University, Vatan Caddesi, Fatih, İstanbul, Turkey.
authors: Yasemin
authors: Y
authors: Akkoyunlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001064:Appendicitis / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015984:Causality; D015897:Comorbidity; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D063847:Mean Platelet Volume / Q000706:statistics & numerical data*; D008875:Middle Aged; D010976:Platelet Count / Q000706:statistics & numerical data*; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Appendicitis; Blood platelets; Complications; Intestinal perforation; Mean platelet volume