title: Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis.
abstract: OBJECTIVE
  Oral submucous fibrosis (OSMF) is a high risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to compare the efficacy of spirulina and aloe vera in the management of OSMF.
  
  
  METHODS
  42 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (spirulina group) and Group B (aloe vera group). Group A was administered 500 mg spirulina in 2 divided doses for 3 months and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Chi-square test. P-value <0.05 was considered to be statistically significant.
  
  
  RESULTS
  The patients in Group A showed significant clinical improvement in mouth opening and ulcers/erosions/vesicles (p < 0.05). However, there was no significant improvement in burning sensation (p = 0.06) and pain associated with the lesion (p = 0.04) among the 2 groups.
  
  
  CONCLUSIONS
  Both the drugs showed improvement in the condition; however spirulina can bring about significant clinical improvements in the symptoms like mouth opening and ulcers/erosion/vesicles. Thus, spirulina appears to be more promising when compared to aloe vera for the treatment of OSMF.
authors: Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka, Saudi Arabia.
authors: Santosh
authors: S
authors: Patil
authors: Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka, Saudi Arabia.
authors: Bader Kureyem
authors: BK
authors: Al-Zarea
authors: Dental Practitioner, Jodhpur, Rajasthan, India.
authors: Sneha
authors: S
authors: Maheshwari
authors: Post Graduate Student, Dept of Oral Medicine and Radiology, Chattisgarh Dental College and Research Institute, Rajnandgaon, Chattisgarh, India.
authors: Rohit
authors: R
authors: Sahu
keywords: Aloe vera; Antioxidant; Oral submucous fibrosis; Spirulina