title: New bioactive flavonoid glycosides isolated from the seeds of Lepidium apetalum Willd.
abstract: Ten flavonoid glycosides, apetalumosides A (1), B1-B7 (2-8), and C (9), quercetin 3-O-(2,6-di-O-β-D-glucopyranosyl)-β-D-glucopyranoside (10), were obtained from the seeds of Lepidium apetalum Willd. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, NMR, and HRESI-TOF-MS). 1-9 were new isolates. The NMR data for 10 was reported here for the first time. On the other hand, activity screening results showed that 1-3 and 10 had triglyceride accumulation inhibitory effects in HepG2 cells. Preliminary structure-activity relationship study revealed that 7-hydroxyl group is an essential moiety.
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors: Pingping
authors: P
authors: Shi
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors: Liping
authors: L
authors: Chao
authors: Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China.
authors: Tingtxing
authors: T
authors: Wang
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China.
authors: Erwei
authors: E
authors: Liu
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China.
authors: Lifeng
authors: L
authors: Han
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors: Qi
authors: Q
authors: Zong
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
authors: Xiaoxia
authors: X
authors: Li
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China. Electronic address: zhwwxzh@263.net.
authors: Yi
authors: Y
authors: Zhang
authors: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China. Electronic address: wangtao@tjutcm.edu.cn.
authors: Tao
authors: T
authors: Wang
mesh_terms: D005419:Flavonoids / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D029686:Lepidium / Q000737:chemistry*; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000378:metabolism
chemical_list: D005419:Flavonoids; D006027:Glycosides; D014280:Triglycerides
keywords: Flavonoid glycosides; HepG2 cells; Lepidium apetalum; Triglyceride accumulation inhibitory effects