title: Cognitive function in Chinese prostate cancer patients on androgen-deprivation therapy: A cross-sectional study.
abstract: OBJECTIVE
  Androgen-deprivation therapy (ADT) is a main treatment option for patients with prostate cancer (PCa), but its effect on cognition remains unclear. The primary purpose of this cross-sectional case-control study was to evaluate the effects of ADT on cognition in Chinese PCa patients.
  
  
  METHODS
  Participants included PCa patients who had undergone ADT (ADT group, n = 33) and patients who did not undergo ADT (non-ADT group, n = 32), as well as age- and education-matched healthy controls (HC group, n = 35). All participants were examined using the neuropsychological battery aimed at assessing several cognitive domains including attention, memory and information processing performance.
  
  
  RESULTS
  The ADT group obtained significantly worse scores than the non-ADT and HC groups in the following neuropsychological tests: Recognition (P < 0.01), WAIS Digit Span forward (P < 0.05), Trailmaking B (P < 0.01) and Stroop Interference test (P < 0.01). No significant difference was found between the non-ADT and HC groups (P > 0.05).
  
  
  CONCLUSIONS
  Chinese PCa patients receiving ADT showed cognitive impairments in several domains including memory, attention and information processing performance.
authors: Department of Neurology, The Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
authors: Jing
authors: J
authors: Yang
authors: Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors: Fei
authors: F
authors: Zhong
authors: Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
authors: Ju
authors: J
authors: Qiu
authors: Laboratory of Neuropsychology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors: Kai
authors: K
authors: Wang
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000009:adverse effects*; D044466:Asian People; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003072:Cognition Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009483:Neuropsychological Tests; D015995:Prevalence; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000523:psychology
chemical_list: D000726:Androgen Antagonists
keywords: androgen-deprivation therapy; cognition; cross-sectional study; prostate cancer