title: Effect of ethanolic extracts of Justicia neesii Ramam. against experimental models of pain and pyrexia.
abstract: OBJECTIVE
  The main objective of this study is to evaluate the analgesic and anti-pyretic activities of ethanolic extracts of Justicia neesii Ramam. by different experimental models.
  
  
  METHODS
  The analgesic activity of plant extract was evaluated against thermal and chemical stimulus induced by Eddy's hot plate and acetic acid respectively in mice. Brewer's yeast induced pyrexia was used to evaluate the antipyretic activity in rats and TAB vaccine induced pyrexia was used to evaluate the antipyretic activity in rabbits.
  
  
  RESULTS
  In the hot plate model 400 mg/kg p.o. dose of J. neesii has shown its maximal effect at 3 h. The results are significant (P < 0.05) and comparable to the values of standard drug pentazocine (30 mg/kg i.p.). In acetic acid induced writhing model 400 mg/kg p.o. of plant extracts have shown highly significant activity (P < 0.001) and better than standard drug indomethacin (10 mg/kg p.o.). The 400 mg/kg p.o. dose of plant extract has given significant results against both yeast induced pyrexia and TAB vaccine induced pyrexia (P< 0.01 and 0.05 respectively). These values are comparable to that of paracetamol 100 mg/kg p.o. standard dose.
  
  
  CONCLUSIONS
  This study shows that the ethanol extract of J. neesii has significant analgesic and antipyretic activity.
authors: Department of Pharmacology, Pydah College of Pharmacy, East Godavari, Kakinada, Andhra Pradesh, India.
authors: Nimmakayala
authors: N
authors: Sridhar
authors: Department of Pharmacology, Pydah College of Pharmacy, East Godavari, Kakinada, Andhra Pradesh, India.
authors: Duggirala Suguna
authors: DS
authors: Lakshmi
authors: Department of Pharmacology, Vaagdevi College of Pharmacy, Hanamkonda, Telangana, India.
authors: Puchchakayala
authors: P
authors: Goverdhan
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D058633:Antipyretics / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D004195:Disease Models, Animal; D000431:Ethanol / Q000737:chemistry; D005260:Female; D005334:Fever / Q000188:drug therapy*; D027902:Justicia / Q000737:chemistry*; D008297:Male; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D011817:Rabbits; D051381:Rats; D023382:Toxicity Tests, Acute
chemical_list: D018712:Analgesics, Non-Narcotic; D058633:Antipyretics; D010936:Plant Extracts; D000431:Ethanol
keywords: Brewer's yeast; TAB vaccine; hot plate; pyrexia; writhing