title: Synthesis and activities towards resistant cancer cells of sulfone and sulfoxide griseofulvin derivatives.
abstract: Griseofulvin, an antifungal drug, has been shown in recent years to have anti-proliferative activities. We report here the synthesis of new analogs of griseofulvin, substituted in 2' by a sulfonyl group or in 3' by a sulfinyl or sulfonyl group. These compounds exhibit good anti-proliferative activities against SCC114 cells, an oral squamous carcinoma cell line showing pronounced centrosome amplification, and unexpected cytotoxic activities on HCC1937 cells, a triple negative breast cancer cell line resistant to microtubule inhibitors.
authors: Institut de Recherche Pierre Fabre, CRDPF/CROE, 3 avenue Hubert Curien, BP 13562, 31035 Toulouse Cedex 1, France. Electronic address: frederic.lieby.muller@pierre-fabre.com.
authors: Frédéric
authors: F
authors: Liéby-Muller
authors: Institut de Recherche Pierre Fabre, CRDPF/CROE, 3 avenue Hubert Curien, BP 13562, 31035 Toulouse Cedex 1, France.
authors: Quentin
authors: Q
authors: Heudré Le Baliner
authors: Institut de Recherche Pierre Fabre, CRDPF/CROE, 3 avenue Hubert Curien, BP 13562, 31035 Toulouse Cedex 1, France.
authors: Serge
authors: S
authors: Grisoni
authors: Institut de Recherche Pierre Fabre, CRDPF/CROE, 3 avenue Hubert Curien, BP 13562, 31035 Toulouse Cedex 1, France.
authors: Emmanuel
authors: E
authors: Fournier
authors: Institut de Recherche Pierre Fabre, CRDPF/CROE, 3 avenue Hubert Curien, BP 13562, 31035 Toulouse Cedex 1, France.
authors: Nicolas
authors: N
authors: Guilbaud
authors: Institut de Recherche Pierre Fabre, CRDPF/CROE, 3 avenue Hubert Curien, BP 13562, 31035 Toulouse Cedex 1, France. Electronic address: frederic.marion@pierre-fabre.com.
authors: Frédéric
authors: F
authors: Marion
mesh_terms: D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D006118:Griseofulvin / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D013450:Sulfones / Q000737:chemistry*; D013454:Sulfoxides / Q000737:chemistry*
chemical_list: D013450:Sulfones; D013454:Sulfoxides; D006118:Griseofulvin
keywords: Cytotoxicity; Griseofulvin; Sulfone; Sulfoxide