title: Preventive Effect of the Korean Traditional Health Drink (Taemyeongcheong) on Acetaminophen-Induced Hepatic Damage in ICR Mice.
abstract: This study was to investigate the preventive effect of taemyeongcheong (TMC, a Korean traditional health drink) on acetaminophen (APAP, 800 mg/kg BW)-induced hepatic damage in ICR mice. TMC is prepared from Saururus chinensis, Taraxacum officinale, Zingiber officinale, Cirsium setidens, Salicornia herbacea, and Glycyrrhizae. A high dose of TMC (500 mg/kg BW) was found to decrease APAP-induced increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase. TMC pretreatment also increased the hepatic levels of hepatic catalase, superoxide dismutase, glutathione peroxidase, and glutathione, and reduced serum levels of the inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6 in mice administered APAP (P<0.05). TMC (500 mg/kg BW) reduced hepatic mRNA levels of TNF-α, IL-1β, IL-6, COX-2, and iNOS by 87%, 84%, 89%, 85%, and 88%, respectively, in mice treated with APAP (P<0.05). Furthermore, histological observations suggested TMC pretreatment dose-dependently prevented APAP-induced hepatocyte damage. These results suggest that TMC could be used as a functional health drink to prevent hepatic damage.
authors: Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Korea.
authors: Ruo-Kun
authors: RK
authors: Yi
authors: Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Korea ; Kimchi Research Institute, Pusan National University, Busan 609-735, Korea.
authors: Jia-Le
authors: JL
authors: Song
authors: Department of Food and Nutrition, Sungshin Women's University, Seoul 142-732, Korea.
authors: Yaung-Iee
authors: YI
authors: Lim
authors: TaeMyeongCheong Co., Gyeonggi 476-205, Korea.
authors: Yong-Kyu
authors: YK
authors: Kim
authors: Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Korea ; Kimchi Research Institute, Pusan National University, Busan 609-735, Korea.
authors: Kun-Young
authors: KY
authors: Park
keywords: acetaminophen; antioxidant enzymes; hepatic damage; taemyeongcheong