title: Macro-quest.
abstract: In this issue of Blood, Paiva et al provide important information on the cell of origin in Waldenström macroglobulinemia (WM), a longstanding puzzle due to conflicting and incomplete data.
authors: MAYO CLINIC.
authors: S Vincent
authors: http://orcid.org/0000-0002-5862-1833
authors: SV
authors: Rajkumar
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D006801:Humans; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000235:genetics*; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics*