title: Lateral Bone Window Closing Technique with Poly-L-Lactic Acid (PLLA) Membrane in the Augmentation of the Maxillary Sinus without Grafting Material: Evaluation of Bone Healing in a Rabbit Model.
abstract: BACKGROUND
  When augmenting the maxillary sinus without grafting material, the method used to cover the bony window is a subject of debate.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the poly-L-lactic acid (PLLA) membrane as closing material of the lateral window in a maxillary sinus augmentation without bone grafting.
  
  
  METHODS
  Augmentation of the maxillary sinus without grafting material and installation of titanium screws that fix the Schneiderian membrane were performed in 18 Japanese male white rabbits. The bony window was covered with a collagen membrane or PLLA membrane or no membrane. The animals were sacrificed at 4 or 8 weeks. New bone volume was calculated radiologically using microcomputed tomography (micro-CT). The samples were analyzed histologically after toluidine blue staining.
  
  
  RESULTS
  No significant differences were observed in the new bone volume, as measured by micro-CT. However, histomorphometric analysis demonstrated the superiority of the PLLA membrane in new bone formation compared with the collagen membrane.
  
  
  CONCLUSIONS
  The PLLA membrane is a suitable material to be applied for tissue regeneration in this animal model.
authors: Oral Implantology and Regenerative Dental Medicine, Department of Masticatory Function Rehabilitation, Graduate School of Medical Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors: Yuki
authors: Y
authors: Kusumoto
authors: Oral Implantology and Regenerative Dental Medicine, Department of Masticatory Function Rehabilitation, Graduate School of Medical Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors: Noriko
authors: N
authors: Tachikawa
authors: Department of Prosthodontic Dentistry for the Function of the TMJ and Occlusion, Kanagawa Dental University, Kanagawa, Japan.
authors: Motohiro
authors: M
authors: Munakata
authors: Oral Implantology and Regenerative Dental Medicine, Department of Masticatory Function Rehabilitation, Graduate School of Medical Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors: Takayuki
authors: T
authors: Miyahara
authors: Oral Implantology and Regenerative Dental Medicine, Department of Masticatory Function Rehabilitation, Graduate School of Medical Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors: Shohei
authors: S
authors: Kasugai
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D001842:Bone and Bones; D003094:Collagen; D008297:Male; D008443:Maxillary Sinus; D011091:Polyesters; D011817:Rabbits; D055114:X-Ray Microtomography
chemical_list: D011091:Polyesters; C033616:poly(lactide); D003094:Collagen
keywords: animal study; biomaterials; bone regeneration; histological analysis; sinus augmentation