title: Diverse array-designed modes of combination therapies in Fangjiomics.
abstract: In line with the complexity of disease networks, diverse combination therapies have been demonstrated potential in the treatment of different patients with complex diseases in a personal combination profile. However, the identification of rational, compatible and effective drug combinations remains an ongoing challenge. Based on a holistic theory integrated with reductionism, Fangjiomics systematically develops multiple modes of array-designed combination therapies. We define diverse "magic shotgun" vertical, horizontal, focusing, siege and dynamic arrays according to different spatiotemporal distributions of hits on targets, pathways and networks. Through these multiple adaptive modes for treating complex diseases, Fangjiomics may help to identify rational drug combinations with synergistic or additive efficacy but reduced adverse side effects that reverse complex diseases by reconstructing or rewiring multiple targets, pathways and networks. Such a novel paradigm for combination therapies may allow us to achieve more precise treatments by developing phenotype-driven quantitative multi-scale modeling for rational drug combinations.
authors: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Jun
authors: J
authors: Liu
authors: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Zhong
authors: Z
authors: Wang
mesh_terms: D019295:Computational Biology / Q000379:methods*; D057225:Data Mining; D016208:Databases, Factual; D004338:Drug Combinations; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D057166:High-Throughput Screening Assays; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D058990:Molecular Targeted Therapy; D018579:Patient Selection; D010641:Phenotype; D015398:Signal Transduction / Q000187:drug effects; D049490:Systems Biology; D018511:Systems Integration; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal