title: Development of a novel carrier optimized for cell sheet transplantation.
abstract: Tissue engineering is a rapidly advancing technology in the field of regenerative medicine. For the transplantation of cell sheets, a carrier must maintain the shape of a cell sheet from a culture dish to affected sites as well as release the sheet easily onto the lesion. In this study, we examined the utility of a novel, poly(lactic acid)-based carrier for cell sheets transplantation to the cornea of dogs and the skin of rats. The poly(lactic acid)-based carrier easily picked a cell sheet up from the dish, fit to the shape of the transplantation sites, and saved time for cell sheets detachment comparing to a conventional carrier. Thus, the poly(lactic acid)-based carrier would be useful for easy cell sheet transplantations.
authors: a Cooperative Major in Advanced Health Science; Graduate School of Bio-Applications and System Engineering; Laboratories of.
authors: Yosuke
authors: Y
authors: Amagai
authors: Kaoru
authors: K
authors: Karasawa
authors: Jung
authors: J
authors: Kyungsook
authors: Akira
authors: A
authors: Matsuda
authors: Masanori
authors: M
authors: Kojima
authors: Jun
authors: J
authors: Watanabe
authors: Toyoji
authors: T
authors: Hibi
authors: Hiroshi
authors: H
authors: Matsuda
authors: Akane
authors: A
authors: Tanaka
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000295:instrumentation; D017690:Cell Transplantation / Q000295:instrumentation* / Q000379:methods*; D002478:Cells, Cultured; D065306:Corneal Injuries / Q000601:surgery*; D016039:Corneal Transplantation / Q000295:instrumentation / Q000379:methods; D004285:Dogs; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers / Q000378:metabolism*; D051381:Rats; D044968:Regenerative Medicine / Q000295:instrumentation; D012867:Skin / Q000293:injuries*; D016038:Skin Transplantation / Q000295:instrumentation / Q000379:methods; D023822:Tissue Engineering / Q000295:instrumentation
chemical_list: D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)
keywords: Carrier; FBS, fetal bovine serum; PBS, phosphate-buffered saline; cell sheet; cornea; poly(lactic acid); transplantation; α-MEM, α-minimum essential medium