title: Candidate genes for hypertension: insights from the Dahl S rat.
abstract: Human genetic linkage and association studies have nominated many genes as possible contributors to disease. Mutating or deleting these genes in a relevant disease model can validate their association with disease and potentially uncover novel mechanisms of pathogenesis. Targeted genetic mutagenesis has only recently been developed in the rat, and this technique has been applied in the Dahl salt-sensitive (S) rat to investigate human candidate genes associated with hypertension. This mini-review communicates the findings of these studies and displays how targeted genetic mutagenesis may contribute to the discovery of novel therapies for patients.
authors: Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin nrudemiller@mcw.edu.
authors: Nathan P
authors: NP
authors: Rudemiller
authors: Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors: David L
authors: DL
authors: Mattson
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000235:genetics*; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation / Q000235:genetics*; D020303:Rats, Inbred Dahl; D012965:Sodium Chloride / Q000378:metabolism*
chemical_list: D012965:Sodium Chloride
keywords: high-salt diet; hypertension; single nucleotide polymorphisms