title: Assessment of dendritic arborization in the dentate gyrus of the hippocampal region in mice.
abstract: Dendritic arborization has been shown to be a reliable marker for examination of structural and functional integrity of neurons. Indeed, the complexity and extent of dendritic arborization correlates well with the synaptic plasticity in these cells. A reliable method for assessment of dendritic arborization is needed to characterize the deleterious effects of neurological disorders on these structures and to determine the effects of therapeutic interventions. However, quantification of these structures has proven to be a formidable task given their complex and dynamic nature. Fortunately, sophisticated imaging techniques can be paired with conventional staining methods to assess the state of dendritic arborization, providing a more reliable and expeditious means of assessment. Below is an example of how these imaging techniques were paired with staining methods to characterize the dendritic arborization in wild type mice. These complementary imaging methods can be used to qualitatively and quantitatively assess dendritic arborization that span a rather wide area within the hippocampal region.
authors: VA Palo Alto Health Care System; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine.
authors: Devsmita
authors: D
authors: Das
authors: Department of Physical Therapy, Arkansas State University.
authors: Cristy
authors: C
authors: Phillips
authors: VA Palo Alto Health Care System.
authors: Bill
authors: B
authors: Lin
authors: VA Palo Alto Health Care System.
authors: Fatemeh
authors: F
authors: Mojabi
authors: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine.
authors: Mehmet
authors: M
authors: Akif Baktir
authors: VA Palo Alto Health Care System; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine.
authors: Van
authors: V
authors: Dang
authors: VA Palo Alto Health Care System.
authors: Ravikumar
authors: R
authors: Ponnusamy
authors: VA Palo Alto Health Care System; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine; asalehi@stanford.edu.
authors: Ahmad
authors: A
authors: Salehi
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology*; D051379:Mice; D023421:Models, Animal; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology