title: Immunohistochemical Similarities between Lichen Sclerosus et Atrophicus and Morphea: A Case Study.
abstract: Both morphea and lichen sclerosus et atrophicus (LSA) are connective tissue diseases that mainly affect the skin. A recent report suggested that a substantial portion of morphea coexists with LSA. In this report, we describe a case of LSA on the abdomen accompanied by morphea; we employed immunohistochemical staining for periostin as well as MMP-7 and MMP-28, both of which are reported to facilitate fibrosis in the development of various organs, including skin. To our knowledge, this is first English language paper that demonstrates the immunohistochemical staining of periostin, MMP-7 and MMP-28 for morphea and LSA. Our present case might suggest possible mechanisms for the coexistence of two different sclerotic skin disorders.
authors: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Aya
authors: A
authors: Kakizaki
authors: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Taku
authors: T
authors: Fujimura
authors: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Sadanori
authors: S
authors: Furudate
authors: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Yumi
authors: Y
authors: Kambayashi
authors: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors: Setsuya
authors: S
authors: Aiba
keywords: Lichen sclerosus et atrophicus; MMP-28; MMP-7; Morphea; Periostin