title: Ru(II)-Catalyzed β-Carboline Directed C-H Arylation and Isolation of Its Cycloruthenated Intermediates.
abstract: A Ru(II)-catalyzed C-H arylation approach has been developed utilizing β-carboline alkaloids as the directing group. Selective formations of diarylated products from moderate to excellent yields were accomplished. Broad substrate scope with excellent functional group tolerance for C1-phenyl/thienyl/PAHs-β-carbolines was demonstrated. X-ray crystal structure of cycloruthenated complex 2cr and no arylation reaction with model substrate 13 strongly suggests that N2 is the directing group than N9 in C1-aryl-β-carbolines. Catalytic properties and stability of the cycloruthenated complexes have been explored. Library of biologically relevant new β-carboline derivatives and isolation of its cycloruthenated intermediates are the highlights of this work.
authors: †Materials Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, India.
authors: Subramani
authors: S
authors: Rajkumar
authors: †Materials Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, India.
authors: Shanmugam
authors: S
authors: Karthik
authors: †Materials Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, India.|‡Centre for Nanomaterials, VIT University, Vellore 632014, Tamil Nadu, India.
authors: Thirumanavelan
authors: T
authors: Gandhi