title: MR-detected changes in liver fat, abdominal fat, and vertebral bone marrow fat after a four-week calorie restriction in obese women.
abstract: OBJECTIVE
  To determine changes in the bone marrow fat fraction (BMFF) in obesity after dietary intervention in comparison with changes in abdominal fat, liver fat, and serum lipids.
  
  
  METHODS
  Twenty obese (BMI 34.92 ± 3.8 kg/m(2) ) women participated in a 4-week dietary intervention of 800 kcal/d plus additional vegetables. They underwent anthropometric and blood value measurements before and after the intervention. Abdominal 3T MRI was performed to measure changes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) volume and single-voxel magnetic resonance spectroscopy (MRS) to measure fat content changes in the liver and L5 vertebral body.
  
  
  RESULTS
  The greatest relative change after dietary intervention was found in the liver (-40.3%), followed by VAT volume (-15.1%), serum lipids (-12.6 to -14.5%), and SAT volume (-8.5%). There were no statistically significant changes in BMFF after dietary intervention (P = 0.39), but absolute changes in the BMFF were positively associated with SAT volume (r = 0.489) and negatively associated with nonadipose tissue volume (r = -0.493) before dietary intervention.
  
  
  CONCLUSIONS
  Bone marrow behaves differently compared to SAT volume, VAT volume, liver fat, and serum lipids after a 4-week dietary intervention in obesity and BMFF changes depend on abdominal tissue volumes before intervention.
authors: Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Christian
authors: C
authors: Cordes
authors: Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Michael
authors: M
authors: Dieckmeyer
authors: Else Kröner Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Beate
authors: B
authors: Ott
authors: Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Jun
authors: J
authors: Shen
authors: Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Stefan
authors: S
authors: Ruschke
authors: Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Marcus
authors: M
authors: Settles
authors: Else Kröner Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Claudia
authors: C
authors: Eichhorn
authors: Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.|Section of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Jan S
authors: JS
authors: Bauer
authors: Philips Healthcare, Hamburg, Germany.
authors: Hendrik
authors: H
authors: Kooijman
authors: Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Ernst J
authors: EJ
authors: Rummeny
authors: Else Kröner Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.|ZIEL Research Center for Nutrition and Food Sciences, Technische Universität München, Germany.
authors: Thomas
authors: T
authors: Skurk
authors: Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Thomas
authors: T
authors: Baum
authors: Else Kröner Fresenius Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.|ZIEL Research Center for Nutrition and Food Sciences, Technische Universität München, Germany.
authors: Hans
authors: H
authors: Hauner
authors: Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors: Dimitrios C
authors: DC
authors: Karampinos
mesh_terms: D050153:Abdominal Fat / Q000473:pathology*; D000273:Adipose Tissue / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology*; D031204:Caloric Restriction; D005234:Fatty Liver / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000178:diet therapy* / Q000473:pathology*
keywords: bone marrow fat fraction; magnetic resonance imaging (MRI); magnetic resonance spectroscopy (MRS); obesity; weight loss