title: Synergistic effects of surface chemistry and topologic structure from modified microarc oxidation coatings on Ti implants for improving osseointegration.
abstract: Microarc oxidation (MAO) coating containing Ca, P, Si, and Na elements on a titanium (Ti) implant has been steam-hydrothermally treated and further mediated by post-heat treatment to overcome the compromised bone-implant integration. The bone regeneration, bone-implant contact, and biomechanical push-out force of the modified Ti implants are discussed thoroughly in this work. The best in vivo performances for the steam-hydrothermally treated one is attributed to the synergistic effects of surface chemistry and topologic structure. Through post-heat treatment, we can decouple the effects of surface chemistry and the nanoscale topologic structure easily. Attributed to the excellent in vivo performance of the surface-modified Ti implant, the steam-hydrothermal treatment could be a promising strategy to improve the osseointegration of the MAO coating covered Ti implant.
authors: †Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, P. R. China.
authors: Rui
authors: R
authors: Zhou
authors: †Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, P. R. China.
authors: Daqing
authors: D
authors: Wei
authors: †Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, P. R. China.
authors: Jianyun
authors: J
authors: Cao
authors: †Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, P. R. China.
authors: Wei
authors: W
authors: Feng
authors: ‡Department of Mechanical Engineering, Harbin University of Science and Technology, Harbin, 150001, P. R. China.
authors: Su
authors: S
authors: Cheng
authors: †Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, P. R. China.
authors: Qing
authors: Q
authors: Du
authors: †Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, P. R. China.
authors: Baoqiang
authors: B
authors: Li
authors: †Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, P. R. China.
authors: Yaming
authors: Y
authors: Wang
authors: †Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, P. R. China.
authors: Dechang
authors: D
authors: Jia
authors: †Department of Materials Science and Engineering, Harbin Institute of Technology, Harbin, 150080, P. R. China.
authors: Yu
authors: Y
authors: Zhou
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000494:pharmacology*; D005453:Fluorescence; D020007:Implants, Experimental; D016348:Osseointegration / Q000187:drug effects*; D010084:Oxidation-Reduction / Q000187:drug effects; D011817:Rabbits; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects; D014961:X-Ray Diffraction; D055114:X-Ray Microtomography
chemical_list: D020099:Coated Materials, Biocompatible; D014025:Titanium
keywords: osseointegration; surface chemistry; surface modification; titanium; topologic structure