title: Clinical Drug Development Using Dynamic Biomarkers to Enable Personalized Health Care in COPD.
abstract: Despite massive investments in the development of novel treatments for heterogeneous diseases such as COPD, the resources spent have only benefited a fraction of the population treated. Personalized health care to guide selection of a suitable patient population already in the clinical development of new compounds could offer a solution. This review discusses past successes and failures in drug development and biomarker research in COPD, describes research in COPD phenotypes and the required characteristics of a suitable biomarker for identifying patients at higher risk of progression, and examines the role of extracellular matrix proteins found to be upregulated in COPD. Novel biomarkers of connective tissue remodeling that may provide added value for a personalized approach by detecting subgroups of patients with active disease suitable for pharmacologic intervention are discussed.
authors: Nordic Bioscience Clinical Development, Herlev, Denmark; Nordic Bioscience, Herlev, Denmark. Electronic address: abi@nordicbioscience.com.
authors: Asger R
authors: AR
authors: Bihlet
authors: Nordic Bioscience, Herlev, Denmark.
authors: Morten A
authors: MA
authors: Karsdal
authors: Nordic Bioscience, Herlev, Denmark.
authors: Anne-Christine
authors: AC
authors: Bay-Jensen
authors: Grünenthal, Aachen, Germany.
authors: Simon
authors: S
authors: Read
authors: Nordic Bioscience Clinical Development, Herlev, Denmark.
authors: Jacob Hull
authors: JH
authors: Kristensen
authors: Nordic Bioscience, Herlev, Denmark.
authors: Jannie Marie Bülow
authors: JMB
authors: Sand
authors: Nordic Bioscience, Herlev, Denmark.
authors: Diana Julie
authors: DJ
authors: Leeming
authors: Nordic Bioscience, Herlev, Denmark.
authors: Jeppe Ragnar
authors: JR
authors: Andersen
authors: Section of Respiratory Medicine, Hvidovre Hospital and Institute of Public Health, Copenhagen University, Copenhagen, Denmark.
authors: Peter
authors: P
authors: Lange
authors: Respiratory and Allergy Research Group, Manchester Academic Science Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, England.
authors: Jørgen
authors: J
authors: Vestbo
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D006302:Health Services Research; D006801:Humans; D018579:Patient Selection; D057285:Precision Medicine; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D015415:Biomarkers