title: Proline-Directed Androgen Receptor Phosphorylation.
abstract: The androgen receptor (AR) has been identified for decades and mediates essential steroid functions. Like most of biological molecules, AR functional activities are modulated by post-translational modifications. This review is focused on the reported activities and significance of AR phosphorylation, with particular emphasis on proline-directed serine/threonine phosphorylation that occurs predominantly on the receptor. The marked enrichment of AR phosphorylation in the most diverse N-terminal domain suggests that targeting AR phosphorylation can be synergistic to antagonizing the C-terminal domain by clinical antiandrogens.
authors: Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School 330 Brookline, MA 02115, USA.
authors: Yanfei
authors: Y
authors: Gao
authors: Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School 330 Brookline, MA 02115, USA.
authors: Shaoyong
authors: S
authors: Chen
keywords: Androgen receptor; Kinases; Phosphatase; Phosphorylation; Proline-directed serine/threonine phosphorylation