title: Are there gender differences in left ventricular remodeling after myocardial infarction in rats?
abstract: OBJECTIVE
  An unclear issue is whether gender may influence at cardiac remodeling after myocardial infarction (MI). We evaluated left ventricle remodeling in female and male rats post-MI.
  
  
  METHODS
  Rats were submitted to anterior descending coronary occlusion. Echocardiographic evaluations were performed on the first and sixth week post-occlusion to determine myocardial infarction size and left ventricle systolic function (FAC, fractional area change). Pulsed Doppler was applied to analyze left ventricle diastolic function using the following parameters: E wave, A wave, E/A ratio. Two-way ANOVA was applied for comparisons, complemented by the Bonferroni test. A P≤=0.05 was considered significant.
  
  
  RESULTS
  There were no significant differences between genders for morphometric parameters on first (MI [Female (FE): 44.0 ± 5.0 vs. Male (MA): 42.0 ± 3.0%]; diastolic [FE: 0.04 ± 0.003 vs. MA: 0.037 ± 0.005, mm/g] and systolic [FE: 0.03 ± 0.0004 vs. MA: 0.028 ± 0.005, mm/g] diameters of left ventricle) and sixth (MI [FE: 44.0 ± 5.0 vs. MA: 42.0 ± 3.0, %]; diastolic [FE: 0.043 ± 0.01 vs. MA: 0.034 ± 0.005, mm/g] and systolic [FE: 0.035 ± 0.01 vs. MA: 0.027 ± 0.005, mm/g] of LV) week. Similar findings were reported for left ventricle functional parameters on first (FAC [FE: 34.0 ± 6.0 vs. MA: 32.0 ± 4.0, %]; wave E [FE: 70.0 ± 18.0 vs. MA: 73.0 ± 14.0, cm/s]; wave A [FE: 20.0 ± 12.0 vs. MA: 28.0 ± 13.0, cm/s]; E/A [FE: 4.9 ± 3.4 vs. MA: 3.3 ± 1.8]) and sixth (FAC [FE: 29.0 ± 7.0 vs. MA: 31.0 ± 7.0, %]; wave E [FE: 85.0 ± 18.0 vs. MA: 87.0 ± 20.0, cm/s]; wave A [FE: 20.0 ± 11.0 vs. MA: 28.0 ± 17.0, cm/s]; E/A [FE: 6.2 ± 4.0 vs. MA: 4.6 ± 3.4]) week.
  
  
  CONCLUSIONS
  Gender does not influence left ventricle remodeling post-MI in rats.
authors: Laboratório de Fisiologia e Fisiopatologia Cardíacas, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Ednei Luiz
authors: EL
authors: Antonio
authors: Universidade Nove de Julho, São Paulo, São Paulo, Brazil.
authors: Andrey Jorge
authors: AJ
authors: Serra
authors: Laboratório de Fisiologia e Fisiopatologia Cardíacas, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Alexandra Alberta
authors: AA
authors: dos Santos
authors: Laboratório de Fisiologia e Fisiopatologia Cardíacas, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Stella Sousa
authors: SS
authors: Vieira
authors: Laboratório de Fisiologia e Fisiopatologia Cardíacas, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Jairo Montemor Augusto
authors: JM
authors: Silva
authors: Programa de Pós-graduação em Ciências da Reabilitação, Universidade Nove de Julho, São Paulo, SP, Brazil.
authors: Amanda
authors: A
authors: Yoshizaki
authors: Universidade Nove de Julho, São Paulo, SP, Brazil.
authors: Renato Rodrigues
authors: RR
authors: Sofia
authors: Laboratório de Fisiologia e Fisiopatologia Cardíacas, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors: Paulo José Ferreira
authors: PJ
authors: Tucci
mesh_terms: D000818:Animals; D003971:Diastole / Q000502:physiology; D004195:Disease Models, Animal; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D017208:Rats, Wistar; D012737:Sex Factors; D013599:Systole / Q000502:physiology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology*