title: Expression of receptor activator of nuclear factor-κB ligand is related to sex differences in collagen-induced arthritis.
abstract: Osteoclasts are responsible for bone destruction in rheumatoid arthritis, and women show greater disease activity and functional disability than men. This study aimed to examine differences in the pathogenesis of collagen-induced arthritis and osteoclastogenesis between female and male mice in vivo and in vitro. Female mice exhibited worse disease progression and increased osteoclastogenesis, as measured by tartrate-resistant acid phosphatase (TRAP) staining than male mice. Significantly higher levels of CD11b(+) cells were detected in the bone marrow of female mice than that of male mice. Furthermore, the mRNA expression of receptor activator of nuclear factor-κB ligand was higher in female mice that were immunized with or without collagen II. These findings highlighted sex differences in arthritis morbidity and suggested that female mice are more likely to develop arthritis than male mice. Further studies are needed to investigate the mechanisms of sex differences in collagen-induced arthritis.
authors: Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University and Liver Transplantation Center of First Affiliated Hospital, Nanjing, China.
authors: Zheng
authors: Z
authors: Ding
authors: Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University and Liver Transplantation Center of First Affiliated Hospital, Nanjing, China.
authors: Qi
authors: Q
authors: Wang
authors: Department of Anesthesiology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors: Xiongxiong
authors: X
authors: Pan
authors: Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University and Liver Transplantation Center of First Affiliated Hospital, Nanjing, China.
authors: Qin
authors: Q
authors: Zhu
authors: Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University and Liver Transplantation Center of First Affiliated Hospital, Nanjing, China.
authors: Hao
authors: H
authors: Lu
authors: Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University and Liver Transplantation Center of First Affiliated Hospital, Nanjing, China.
authors: Kunpeng
authors: K
authors: Wang
authors: Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University and Liver Transplantation Center of First Affiliated Hospital, Nanjing, China.
authors: Xuhao
authors: X
authors: Ni
authors: Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University and Liver Transplantation Center of First Affiliated Hospital, Nanjing, China. Electronic address: 21298533@qq.com.
authors: Yunjie
authors: Y
authors: Lu
authors: Translational Medicine Research Center of Jiangning Hospital, Nanjing Medical University and Liver Transplantation Center of First Affiliated Hospital, Nanjing, China. Electronic address: jiangu0304@163.com.
authors: Jian
authors: J
authors: Gu
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D039481:CD11b Antigen / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010010:Osteoclasts / Q000276:immunology; D053245:RANK Ligand / Q000235:genetics / Q000276:immunology*; D012333:RNA, Messenger / Q000378:metabolism; D012727:Sex Characteristics; D013154:Spleen / Q000276:immunology
chemical_list: D039481:CD11b Antigen; D016207:Cytokines; D007074:Immunoglobulin G; D053245:RANK Ligand; D012333:RNA, Messenger; C505689:Tnfsf11 protein, mouse
keywords: CD11b; Osteoclast cells; RANKL; Sex difference