title: World Workshop on Oral Medicine VI: clinical implications of medication-induced salivary gland dysfunction.
abstract: OBJECTIVE
  This study aimed to systematically review the available literature on the clinical implications of medication-induced salivary gland dysfunction (MISGD).
  
  
  METHODS
  The systematic review was performed using PubMed, Embase, and Web of Science (through June 2013). Studies were assessed for degree of relevance and strength of evidence, based on whether clinical implications of MISGD were the primary study outcomes, as well as on the appropriateness of study design and sample size.
  
  
  RESULTS
  For most purported xerogenic medications, xerostomia was the most frequent adverse effect. In the majority of the 129 reviewed papers, it was not documented whether xerostomia was accompanied by decreased salivary flow. Incidence and prevalence of medication-induced xerostomia varied widely and was often associated with number and dose of medications. Xerostomia was most frequently reported to be mild-to-moderate in severity. Its onset occurred usually in the first weeks of treatment. There was selected evidence that medication-induced xerostomia occurs more frequently in women and older adults and that MISGD may be associated with other clinical implications, such as caries or oral mucosal alterations.
  
  
  CONCLUSIONS
  The systematic review showed that MISGD constitutes a significant burden in many patients and may be associated with important negative implications for oral health.
authors: Faculty of Dental Medicine, University of Medicine, Tirana, Albania; Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
authors: Ardita
authors: A
authors: Aliko
authors: Tel-Aviv Sourasky Medical Center and Saliwell Ltd., Tel Aviv, Israel. Electronic address: Awolff@zahav.net.il.
authors: Andy
authors: A
authors: Wolff
authors: Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada.
authors: Colin
authors: C
authors: Dawes
authors: The Hebrew University, Jerusalem, Israel.
authors: Doron
authors: D
authors: Aframian
authors: Dental Institute, King's College, London, UK.
authors: Gordon
authors: G
authors: Proctor
authors: Department of Pharmacology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
authors: Jörgen
authors: J
authors: Ekström
authors: Department of Oral Biology, University of Nebraska Medical Center College of Dentistry, Lincoln, Nebraska, USA.
authors: Nagamani
authors: N
authors: Narayana
authors: Department of General Dentistry, Henry M. Goldman School of Dental Medicine, Boston University, Boston, Massachusetts, USA.
authors: Alessandro
authors: A
authors: Villa
authors: McGill University, Montreal, Quebec, Canada.
authors: Ying Wai
authors: YW
authors: Sia
authors: DAPMRV Dental College, Bangalore, Karnataka, India.
authors: Revan Kumar
authors: RK
authors: Joshi
authors: New York University College of Dentistry, New York, New York, USA.
authors: Richard
authors: R
authors: McGowan
authors: Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: Siri
authors: S
authors: Beier Jensen
authors: New York University College of Dentistry, New York, New York, USA.
authors: A Ross
authors: AR
authors: Kerr
authors: Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
authors: Anne Marie
authors: AM
authors: Lynge Pedersen
authors: University of Groningen and University Medical Center, Groningen, The Netherlands.
authors: Arjan
authors: A
authors: Vissink
mesh_terms: D006801:Humans; D012307:Risk Factors; D012466:Salivary Gland Diseases / Q000139:chemically induced*; D012472:Salivation / Q000187:drug effects*