title: Asymmetric Synthesis of P-Stereogenic Phosphinic Amides via Pd(0)-Catalyzed Enantioselective Intramolecular C-H Arylation.
abstract: The palladium-catalyzed enantioselective intramolecular C-H arylation of N-(2-haloaryl)-P,P-diphenylphosphinic amides furnishes P-stereogenic phosphine oxide derivatives in 61-99% yield with 88-97% ee. The catalyst generated in situ from a TADDOL-derived phosphoramide ligand and Pd(dba)2 is optimum in terms of yield and enantioselectivities.
authors: †College of Chemistry and Chemical Engineering, Shangqiu Normal University, 298 Wenhua Road, Shangqiu, Henan 476000, China.
authors: Lantao
authors: L
authors: Liu
authors: †College of Chemistry and Chemical Engineering, Shangqiu Normal University, 298 Wenhua Road, Shangqiu, Henan 476000, China.
authors: An-An
authors: AA
authors: Zhang
authors: Yanfang
authors: Y
authors: Wang
authors: †College of Chemistry and Chemical Engineering, Shangqiu Normal University, 298 Wenhua Road, Shangqiu, Henan 476000, China.
authors: Fuqiang
authors: F
authors: Zhang
authors: †College of Chemistry and Chemical Engineering, Shangqiu Normal University, 298 Wenhua Road, Shangqiu, Henan 476000, China.
authors: Zhenzhen
authors: Z
authors: Zuo
authors: †College of Chemistry and Chemical Engineering, Shangqiu Normal University, 298 Wenhua Road, Shangqiu, Henan 476000, China.
authors: Wen-Xian
authors: WX
authors: Zhao
authors: †College of Chemistry and Chemical Engineering, Shangqiu Normal University, 298 Wenhua Road, Shangqiu, Henan 476000, China.
authors: Cui-Lan
authors: CL
authors: Feng
authors: Wenjin
authors: W
authors: Ma