title: Photodamage attenuation effect by a tetraprenyltoluquinol chromane meroterpenoid isolated from Sargassum muticum.
abstract: A tetraprenyltoluquinol meroterpenoid with a chromane moiety, obtained as an epimeric mixture at C3, was isolated for the first time from the dichloromethane fraction of a methanolic extract from the brown alga Sargassum muticum. The structure has been established by means of spectral methods including NMR spectroscopy and MS and comparison with reported data. The compound showed photodamage attenuation on irradiated cells with UVA light, presented protection against intracellular ROS generation in a degree comparable to retinoic acid (9.1-20.6%) and did not display toxicity against human dermal fibroblast cells.
authors: Department of Chemical Engineering, Faculty of Science, Campus Ourense, University of Vigo, Spain; CITI-University of Vigo, Parque Tecnolóxico de Galicia, Ourense, Spain. Electronic address: elenamba@uvigo.es.
authors: E M
authors: EM
authors: Balboa
authors: Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea; Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address: lyxycg@qq.com.
authors: Y-X
authors: YX
authors: Li
authors: Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea; Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address: icetwig@naver.com.
authors: B-N
authors: BN
authors: Ahn
authors: Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea; Marine Bioprocess Research Center, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address: dalgoo52@gmail.com.
authors: S-H
authors: SH
authors: Eom
authors: Department of Chemical Engineering, Faculty of Science, Campus Ourense, University of Vigo, Spain; CITI-University of Vigo, Parque Tecnolóxico de Galicia, Ourense, Spain. Electronic address: herminia@uvigo.es.
authors: H
authors: H
authors: Domínguez
authors: Centro de Investigacións Científicas Avanzadas (CICA), Departamento Química Fundamental, Facultade de Ciencias, Universidade da Coruña, A Coruña E-15071, Spain. Electronic address: carlos.jimenez@udc.es.
authors: C
authors: C
authors: Jiménez
authors: Centro de Investigacións Científicas Avanzadas (CICA), Departamento Química Fundamental, Facultade de Ciencias, Universidade da Coruña, A Coruña E-15071, Spain. Electronic address: jaime.rodriguez@udc.es.
authors: J
authors: J
authors: Rodríguez
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002839:Chromans / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008855:Microscopy, Electron, Scanning; D008968:Molecular Conformation; D020011:Protective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D044647:Sargassum / Q000737:chemistry* / Q000378:metabolism; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014466:Ultraviolet Rays
chemical_list: D000975:Antioxidants; D002839:Chromans; D020011:Protective Agents; D017382:Reactive Oxygen Species; D013729:Terpenes