title: Inhibition of Autophagy by MiR-30A Induced by Mycobacteria tuberculosis as a Possible Mechanism of Immune Escape in Human Macrophages.
abstract: The regulatory mechanism of miRNA induction in response to Mycobacterium tuberculosis (MTB) infection has not been clearly established. Autophagy has recently been identified as an effective way to control intracellular survival of MTB. In the present study, we demonstrate a novel role of miR-30A in the negative regulation of the autophagy-mediated anti-MTB response. We found that overexpression of miR-30A suppresses the elimination of intracellular MTB through the inhibition of autophagy. Furthermore, there was a negative correlation between concentrations of miR-30A and beclin-1 in MTB positive patients and miR-30A expression decreased after anti-TB treatment. Our results indicate that miR-30A plays a key role in immune response against MTB and, therefore, may serve as a potential target for future treatments of tuberculosis infection.
authors: Institute of Tuberculosis Research, the 309th Hospital of PLA.
authors: Zhi
authors: Z
authors: Chen
authors: Tongjian
authors: T
authors: Wang
authors: Zhen
authors: Z
authors: Liu
authors: Guangyu
authors: G
authors: Zhang
authors: Jinhe
authors: J
authors: Wang
authors: Shisheng
authors: S
authors: Feng
authors: Jianqin
authors: J
authors: Liang
mesh_terms: D001343:Autophagy / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D035683:MicroRNAs / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*
chemical_list: C546086:MIRN30b microRNA, human; D035683:MicroRNAs