title: An interictal schizophrenia-like psychosis in an adult patient with 22q11.2 deletion syndrome.
abstract: In addition to causing polymalformative syndrome, 22q11.2 deletion can lead to various neuropsychiatric disorders including mental retardation, psychosis, and epilepsy. However, few reports regarding epilepsy-related psychosis in 22q11.2 deletion syndrome (22q11.2DS) exist. We describe the clinical characteristics and course of 22q11.2DS in a Japanese patient with comorbid mild mental retardation, childhood-onset localization-related epilepsy, and adult-onset, interictal schizophrenia-like psychosis. From a diagnostic viewpoint, early detection of impaired intellectual functioning and hyperprolinemia in patients with epilepsy with 22q11.2DS may be helpful in predicting the developmental timing of interictal psychosis. From a therapeutic viewpoint, special attention needs to be paid to phenytoin-induced hypocalcemia in this syndrome.
authors: Department of Psychiatry, National Defense Medical College, Saitama, Japan.
authors: Yasutaka
authors: Y
authors: Tastuzawa
authors: Department of Pediatrics, National Defense Medical College, Saitama, Japan.
authors: Kanako
authors: K
authors: Sekikawa
authors: Department of Psychiatry, National Defense Medical College, Saitama, Japan.
authors: Tetsufumi
authors: T
authors: Suda
authors: Department of Pediatrics, National Defense Medical College, Saitama, Japan.
authors: Hiroshi
authors: H
authors: Matsumoto
authors: Department of Psychiatry, National Defense Medical College, Saitama, Japan.
authors: Hiroyuki
authors: H
authors: Otabe
authors: Department of Pediatrics, National Defense Medical College, Saitama, Japan.
authors: Shigeaki
authors: S
authors: Nonoyama
authors: Department of Psychiatry, National Defense Medical College, Saitama, Japan.
authors: Aihide
authors: A
authors: Yoshino
keywords: 22q11.2 deletion syndrome; DiGeorge syndrome; Epilepsy; Hyperprolinemia; Interictal psychosis; Mental retardation; Phenytoin-induced hypocalcemia