title: Activation of ERK1/2 is required for the antimitotic activity of the resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) in human melanoma cells.
authors: Laboratory of Experimental Dermatology, Medical School, University of Crete, Voutes, Heraklion, Crete, Greece.
authors: Vasilis Pericles
authors: VP
authors: Androutsopoulos
authors: Laboratory of Experimental Dermatology, Medical School, University of Crete, Voutes, Heraklion, Crete, Greece.
authors: Irene
authors: I
authors: Fragiadaki
authors: Laboratory of Experimental Dermatology, Medical School, University of Crete, Voutes, Heraklion, Crete, Greece.
authors: Androniki
authors: A
authors: Tosca
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004789:Enzyme Activation / Q000187:drug effects; D059565:G2 Phase Cell Cycle Checkpoints / Q000187:drug effects*; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects*; D008545:Melanoma / Q000473:pathology*; D019950:Mitogen-Activated Protein Kinase 1 / Q000502:physiology; D048052:Mitogen-Activated Protein Kinase 3 / Q000502:physiology; D009363:Neoplasm Proteins / Q000502:physiology; D010766:Phosphorylation / Q000187:drug effects; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D021381:Protein Transport / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: C482492:3,4,5,4'-tetramethoxystilbene; D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D013267:Stilbenes; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3
keywords: resveratrol-antimitotic-apoptosis-cell cycle-stilbenes-ERK