title: Ltb4r1 inhibitor: A pivotal insulin sensitizer?
abstract: The potent chemokine leukotriene B4 (LTB4) is increased in obesity, and is associated with insulin resistance. A recent article shows that inhibition of its receptor LTB4 receptor 1 (Ltb4r1) improves insulin sensitivity in muscle and liver via cytokine-independent mechanisms, and reduces proinflammatory immune cell infiltration in the adipose tissue.
authors: Storr Liver Centre, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, New South Wales 2145, Australia; Liver and Pancreatobiliary Diseases Research Centre, Digestive Disease Research Institute, Shariati Hospital, Tehran university of Medical Sciences, Tehran, Iran. Electronic address: saeed.esmaili@sydney.edu.au.
authors: Saeed
authors: S
authors: Esmaili
authors: Storr Liver Centre, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Sydney, New South Wales 2145, Australia. Electronic address: jacob.george@sydney.edu.au.
authors: Jacob
authors: J
authors: George
mesh_terms: D000818:Animals; D022781:Hepatocytes / Q000276:immunology*; D007333:Insulin Resistance / Q000276:immunology*; D007975:Leukotriene B4 / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D018485:Muscle Fibers, Skeletal / Q000276:immunology*; D009765:Obesity / Q000276:immunology*; D018102:Receptors, Leukotriene B4 / Q000276:immunology*
chemical_list: D018102:Receptors, Leukotriene B4; D007975:Leukotriene B4
keywords: inflammation; insulin sensitivity; leukotriene B4; leukotriene B4 receptor; obesity