title: Relationship of glomerular filtration rate based on serum iodixanol clearance to IRIS staging in cats with chronic kidney disease.
abstract: We examined the correlation between the glomerular filtration rate (GFR) estimated from an equation based on the serum iodixanol clearance technique and International Renal Interest Society (IRIS) stages of chronic kidney disease (CKD) in cats. The equation included the injection dose, sampling time, serum concentration and estimated volume of distribution (Vd) of the isotonic, nonionic, contrast medium iodixanol as a test tracer. The percent changes in the median basal GFR values calculated from the equation in CKD cats resembled those of IRIS stages 1-3. These data validate the association between the GFR derived from the simplified equation and IRIS stages based on the serum creatinine concentration in cats with CKD. They describe the GFR ranges determined using single-sample iodixanol clearance for healthy cats and cats with various IRIS stages of CKD.
authors: Cooperative Department of Veterinary Basic Medicine, Iwate University, Morioka, Iwate 020-8550, Japan.
authors: Ryosuke
authors: R
authors: Iwama
authors: Tsubasa
authors: T
authors: Sato
authors: Masaaki
authors: M
authors: Katayama
authors: Shunsuke
authors: S
authors: Shimamura
authors: Hiroshi
authors: H
authors: Satoh
authors: Toshihiro
authors: T
authors: Ichijo
authors: Kazuhisa
authors: K
authors: Furuhama
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D002371:Cat Diseases / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D002415:Cats; D003287:Contrast Media / Q000493:pharmacokinetics*; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary*; D012720:Severity of Illness Index; D014283:Triiodobenzoic Acids / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D003404:Creatinine; C044834:iodixanol