title: Diffusion Tensor Imaging in brain tumors: A study on gliomas and metastases.
abstract: OBJECTIVE
  To explore the role of Diffusion Tensor Imaging in preoperative glioma grading, as well as in differentiation between gliomas and metastatic brain tumors. We measured diffusion tensor variables in enhancement and edema regions, which were compared between the different subject groups.
  
  
  METHODS
  We performed DTI in 48 patients (11 Low Grade Gliomas, 27 High Grade Gliomas, 10 Single Metastatic brain tumors). We measured FA, λ1, λ2, λ3, ADC, Cl, Cp, Cs, RA, and VR in enhancing portions of tumors and edema regions. Additionally, ratios of enhancement to edema values were created for each variable.
  
  
  RESULTS
  In peritumoral edema, Cl and RA were proven to be significantly different in pair-wise comparisons, in addition to ADC, Cp, Cs and VR in enhancement regions. Enhancement to edema values were significantly different as well.
  
  
  CONCLUSIONS
  Diffusion tensor indices could be used for the differentiation between low and high grade gliomas, as well as for distinction between gliomas and metastases.
authors: Medical Physics Laboratory, Department of Medicine, Aristotle University of Thessaloniki, 54124, Greece. Electronic address: thpapaphysics@gmail.com.
authors: T S
authors: TS
authors: Papageorgiou
authors: Department of Radiology, Interbalkan Medical Center, 57001 Thessaloniki, Greece. Electronic address: dchourm@hol.gr.
authors: D
authors: D
authors: Chourmouzi
authors: Department of Radiology, Interbalkan Medical Center, 57001 Thessaloniki, Greece. Electronic address: drevradauth@gmail.com.
authors: A
authors: A
authors: Drevelengas
authors: Laboratory of Radiology, Department of Medicine, Aristotle University of Thessaloniki, 54124, Greece. Electronic address: coskou@auth.gr.
authors: K
authors: K
authors: Kouskouras
authors: Medical Physics Laboratory, Department of Medicine, Aristotle University of Thessaloniki, 54124, Greece. Electronic address: tasosks@med.auth.gr.
authors: A
authors: A
authors: Siountas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis
keywords: Diffusion Tensor Imaging; Glioma grading; Magnetic resonance imaging