title: Adoptive T-cell immunotherapy for ganciclovir-resistant CMV disease after lung transplantation.
abstract: Infections with cytomegalovirus (CMV) can induce severe complications after solid organ transplantation (SOT). The prognosis for ganciclovir-resistant CMV infection and disease is particularly poor. Whereas adoptive transfer of CMV-specific T cells has emerged as a powerful tool in hematopoietic stem cell transplant patients, its translation into the SOT setting remains a significant challenge as underlying immunosuppression inhibits the virus-specific T-cell response in vivo. Here, we demonstrate successful expansion and adoptive transfer of autologous CMV-specific T cells from a seronegative recipient of a seropositive lung allograft with ganciclovir-resistant CMV disease, resulting in the long-term reconstitution of protective anti-viral immunity, CMV infection, disease-free survival and no allograft rejection.
authors: South Australian Lung Transplant Unit, Department of Thoracic Medicine, Royal Adelaide Hospital , Adelaide, South Australia, Australia ; Faculty of Health Sciences, School of Medicine, University of Adelaide , Adelaide, South Australia, Australia.
authors: Chien-Li
authors: CL
authors: Holmes-Liew
authors: South Australian Lung Transplant Unit, Department of Thoracic Medicine, Royal Adelaide Hospital , Adelaide, South Australia, Australia ; Faculty of Health Sciences, School of Medicine, University of Adelaide , Adelaide, South Australia, Australia.
authors: Mark
authors: M
authors: Holmes
authors: QIMR Centre for Immunotherapy and Vaccine Development, QIMR Berghofer Medical Research Institute , Brisbane, Queensland, Australia.
authors: Leone
authors: L
authors: Beagley
authors: Queensland Lung Transplant Service, The Prince Charles Hospital , Brisbane, Queensland, Australia ; School of medicine, The University of Queensland , Brisbane, Queensland, Australia.
authors: Peter
authors: P
authors: Hopkins
authors: Queensland Lung Transplant Service, The Prince Charles Hospital , Brisbane, Queensland, Australia ; School of medicine, The University of Queensland , Brisbane, Queensland, Australia.
authors: Daniel
authors: D
authors: Chambers
authors: QIMR Centre for Immunotherapy and Vaccine Development, QIMR Berghofer Medical Research Institute , Brisbane, Queensland, Australia.
authors: Corey
authors: C
authors: Smith
authors: QIMR Centre for Immunotherapy and Vaccine Development, QIMR Berghofer Medical Research Institute , Brisbane, Queensland, Australia.
authors: Rajiv
authors: R
authors: Khanna