title: [Clinical characteristics and prognosis in 20 patients with spindle cell carcinoma of the breast].
abstract: OBJECTIVE
  To investigate the clinical features, appropriate diagnosis and prognosis of spindle cell carcinoma of the breast (SpCC).
  
  
  METHODS
  Clinicopathological data of 20 patients with histopathologically confirmed breast SpCC treated in Tianjin Cancer Hospital from 2004 to 2013 were reviewed retrospectively. The survival rate was calculated by Kaplan-Meier analysis.
  
  
  RESULTS
  All the patients were female and their median age was 54 years. The median maximum diameter of the tumor was 3.8 cm. The misdiagnosis rate was high by mammography, B-ultrasound and core needle biopsy (CNB) before operation. So that the diagnosis primarily depended on postoperative histopathological examination. The positive expression rate of estrogen receptor (ER), progesterone receptor (PR) and human-epidermal growth factor receptor-2 (HER-2) was low. The over-expression rate of Ki-67 was 68.8%. The positive expression rate of EGFR was 63.6%. The median follow-up time of the 20 patients was 32 months and their 3-year overall survival rate and 3-year disease-free survival rate were 80.6% and 57.2%, respectively.
  
  
  CONCLUSIONS
  Spindle cell carcinoma of the breast is rare and has a poor prognosis. The expressions of ER, PR and HER-2 in most samples are negative, Ki-67 is overexpressed, and positive rate of EGFR is high. This disease is highly invasive, and the best treatment modality is comprehensive therapy mainly based on radical resection.
authors: The Second Department of Breast Cancer Surgery, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China.
authors: Yan
authors: Y
authors: Liang
authors: The Second Department of Breast Cancer Surgery, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China.
authors: Lina
authors: L
authors: Zhang
authors: The Second Department of Breast Cancer Surgery, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China.
authors: Yanfang
authors: Y
authors: Yang
authors: The Second Department of Breast Cancer Surgery, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China.
authors: Jun
authors: J
authors: Liu
authors: The Second Department of Breast Cancer Surgery, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education, Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, China. Email: gulindr@yahoo.com.
authors: Lin
authors: L
authors: Gu
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D002277:Carcinoma / Q000175:diagnosis*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human