title: Third-hand Smoke: Impact on Hemostasis and Thrombogenesis.
abstract: Cigarette smoking is a major risk factor for acute coronary thrombosis. In fact, both active/first-hand smoke and passive/second-hand smoke exposure are known to increase the risk of coronary thrombosis. Although recently a new risk has been identified and termed third-hand smoke (THS), which is the residual tobacco smoke contaminant that remains after a cigarette is extinguished, it remains to be determined whether it can also enhance the risk of thrombogenesis, much like first-hand smoke and second-hand smoke. Therefore, the present studies investigated the impact of THS exposure in the context of platelet biology and related disease states. It was found that THS-exposed mice exhibited an enhanced platelet aggregation and secretion responses as well as enhanced integrin GPIIb-IIIa activation. Furthermore, it was found that THS exposure shortens the tail bleeding time and the occlusion time in a model of thrombosis. Thus, our data demonstrate for the first time (at least in mice) that THS exposure increases the risk of thrombosis-based disease states, which is attributed, at least in part, to their hyperactive platelets.
authors: *Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA; and †Department of Cell Biology and Neuroscience, University of California, Riverside, CA.
authors: Zubair A
authors: ZA
authors: Karim
authors: Fatima Z
authors: FZ
authors: Alshbool
authors: Hari Priya
authors: HP
authors: Vemana
authors: Neema
authors: N
authors: Adhami
authors: Sandeep
authors: S
authors: Dhall
authors: Enma V P
authors: EV
authors: Espinosa
authors: Manuela
authors: M
authors: Martins-Green
authors: Fadi T
authors: FT
authors: Khasawneh
mesh_terms: D000818:Animals; D002341:Carotid Artery Thrombosis / Q000097:blood / Q000139:chemically induced*; D006487:Hemostasis / Q000187:drug effects* / Q000502:physiology; D019570:Inhalation Exposure / Q000009:adverse effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D062789:Tobacco Products / Q000009:adverse effects*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D014028:Tobacco Smoke Pollution