title: Ventilator-associated pneumonia rates after introducing selective digestive tract decontamination.
abstract: The incidence of ventilator-associated pneumonia (VAP) before and after the introduction of selective oral decontamination (SOD) only and selective digestive tract decontamination (SDD) in a general intensive care population was examined. SOD as standard of care was introduced in December 2010 and SDD, including SOD, in January 2012 for all patients with an expected length of intensive care unit (ICU) stay of at least 48 h. The diagnosis of VAP was based on clinical criteria and quantitative cultures of bronchoalveolar lavage fluid. A total of 4945 mechanically ventilated patients accounting for 37 554 ventilator days in the period from 2005 to 2013 were analyzed. The incidence of VAP per 1000 ventilator days declined significantly from 4.38 ± 1.64 before to 1.64 ± 0.43 after introduction of SOD/SDD (p = 0.007). Implementation of SOD/SDD as standard of care in ICUs may thus be effective in preventing VAP.
authors: From the Department of Intensive Care Medicine, Maastricht University Medical Centre+ , The Netherlands.
authors: Ronny M
authors: RM
authors: Schnabel
authors: Johannes B J
authors: JB
authors: Scholte
authors: Kim E H M
authors: KE
authors: Van Der Velden
authors: Paul M H J
authors: PM
authors: Roekaerts
authors: Dennis C J J
authors: DC
authors: Bergmans
mesh_terms: D061605:Administration, Intravenous; D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D018893:Bronchoalveolar Lavage; D015331:Cohort Studies; D003422:Critical Care / Q000379:methods / Q000706:statistics & numerical data; D003666:Decontamination / Q000379:methods* / Q000706:statistics & numerical data*; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D053717:Pneumonia, Ventilator-Associated / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Bronchoalveolar lavage; antibacterial agents; critical care; decontamination; preventive measures