title: Poly(α-Peptoid)s Revisited: Synthesis, Properties, and Use as Biomaterial.
abstract: Polypeptoids have been of great interest in the polymer science community since the early half of the last century; however, they had been basically forgotten materials until the last decades in which they have enjoyed an exciting revival. In this mini-review, we focus on the recent developments in polypeptoid chemistry, with particular focus on polymers synthesized by the ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs). Specifically, we will review traditional monomer synthesis (such as Leuchs, Katchalski, and Kricheldorf) and recent advances in polymerization methods to yield both linear, cyclic, and functional polymers, solution and bulk thermal properties, and preliminary results on the use of polypeptoids as biomaterials (i.e immunogenicity, biodistribution, degradability, and drug delivery).
authors: Department of Colloid Chemistry, Max Planck Institute of Colloids and Interfaces, Research Campus Golm, 14424, Potsdam, Germany.
authors: Christian
authors: C
authors: Secker
authors: Department of Colloid Chemistry, Max Planck Institute of Colloids and Interfaces, Research Campus Golm, 14424, Potsdam, Germany.
authors: Sarah M
authors: SM
authors: Brosnan
authors: Department of Chemistry and Pharmacy, Chair of Chemical Technology of Materials Synthesis, University of Würzburg, Röntgenring 11, 97070, Würzburg, Germany.
authors: Robert
authors: R
authors: Luxenhofer
authors: Institute of Chemistry, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476, Potsdam, Germany. schlaad@uni-potsdam.de.
authors: Helmut
authors: H
authors: Schlaad
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D034444:Peptoids / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D034444:Peptoids
keywords: amino acid N-carboxyanhydride (NCA); biomaterials; peptides; properties; ring-opening polymerization