title: Metabolic correction: a functional biochemical mechanism against disease--Part 1: concept and historical background.
abstract: Human physiology depends on countless biochemical reactions, numerous of which are co-dependent and interrelated. The speed and level of completion of reactions usually depend on the availability of precursors and enzymes. The enzymatic activity depends on the bioavailability of micronutrient cofactors such as vitamins and minerals. In order to achieve a healthy physiological state, the organism requires that biochemical reactions occur at a controlled rate. To achieve this state it is required that metabolic reactions reach what can be considered an optimal metabolic equilibrium. A combination of genetic makeup, dietary patterns, trauma, disease, toxins, medications, and environmental stressors can elevate the demand for the nutrients needed to reach this optimal metabolic equilibrium. In this, part 1, the general concept of metabolic correction is presented with an elaboration explaining how this concept is increasing in importance as we become aware of the presence of genetic variants that affect enzymatic reactions causing metabolic disturbances that themselves favor or promote the disease state. In addition, part 1 reviews how prominent scientists have contributed in fundamental ways to our understanding of the importance of micronutrients in health and disease and in the development of the metabolic correction concept.
authors: Michael J
authors: MJ
authors: González
authors: Jorge R
authors: JR
authors: Miranda-Massari
authors: Jorge
authors: J
authors: Duconge
authors: Myriam Z
authors: MZ
authors: Allende-Vigo
authors: Francisco J
authors: FJ
authors: Jiménez-Ramírez
authors: Kenneth
authors: K
authors: Cintrón
authors: Jose R
authors: JR
authors: Rodríguez-Gómez
authors: Glorivee
authors: G
authors: Rosario
authors: Carlos
authors: C
authors: Ricart
authors: Juan A
authors: JA
authors: Santiago-Cornier
authors: Rafael
authors: R
authors: Zaragoza-Urdaz
authors: Alex
authors: A
authors: Vázquez
authors: Steve
authors: S
authors: Hickey
authors: Miguel
authors: M
authors: Jabbar-Berdiel
authors: Neil
authors: N
authors: Riordan
authors: Thomas
authors: T
authors: Ichim
authors: Oscar
authors: O
authors: Santiago
authors: Gilberto
authors: G
authors: Alvarado
authors: Pramod
authors: P
authors: Vora
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D005502:Food; D014644:Genetic Variation; D006801:Humans; D008659:Metabolic Diseases / Q000235:genetics / Q000503:physiopathology*; D018977:Micronutrients / Q000378:metabolism*; D008903:Minerals / Q000378:metabolism; D014815:Vitamins / Q000378:metabolism
chemical_list: D004798:Enzymes; D018977:Micronutrients; D008903:Minerals; D014815:Vitamins