title: The relationship of serum macrophage inhibitory cytokine-1 levels with gray matter volumes in community-dwelling older individuals.
abstract: Using circulating inflammatory markers and magnetic resonance imaging (MRI), recent studies have associated inflammation with brain volumetric measures. Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) is a divergent transforming growth factor - beta (TGF-β) superfamily cytokine. To uncover the underlying mechanisms of the previous finding of a negative association between MIC-1/GDF15 serum levels and cognition, the present study aimed to examine the relationship of circulating MIC-1/GDF15 levels with human brain gray matter (GM) volumes, in a community-dwelling sample aged 70-90 years over two years (Wave 1: n = 506, Wave 2: n = 327), of which the age-related brain atrophy had been previously well defined. T1-weighted MRI scans were obtained at both waves and analyzed using the FMRIB Software Library and FreeSurfer. The results showed significantly negative associations between MIC-1/GDF15 serum levels and both subcortical and cortical GM volumes. GM volumes of the whole brain, cortex, temporal lobe, thalamus and accumbens showed significant mediating effects on the associations between MIC-1/GDF15 serum levels and global cognition scores. Increases in MIC-1/GDF15 serum levels were associated with decreases in cortical and subcortical GM volume over two years. In conclusion, MIC-1/GDF15 serum levels were inversely associated with GM volumes both cross-sectionally and longitudinally.
authors: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia.
authors: Jiyang
authors: J
authors: Jiang
authors: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick NSW, Australia.
authors: Wei
authors: W
authors: Wen
authors: Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia.
authors: David A
authors: DA
authors: Brown
authors: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia.
authors: John
authors: J
authors: Crawford
authors: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia.
authors: Anbupalam
authors: A
authors: Thalamuthu
authors: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia.
authors: Evelyn
authors: E
authors: Smith
authors: Centre for Applied Medical Research, St. Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia.
authors: Samuel N
authors: SN
authors: Breit
authors: School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
authors: Tao
authors: T
authors: Liu
authors: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
authors: Wanlin
authors: W
authors: Zhu
authors: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia; Aged Care Psychiatry, Prince of Wales Hospital, Randwick NSW, Australia; Dementia Collaborative Research Centre, University of New South Wales, Sydney NSW, Australia.
authors: Henry
authors: H
authors: Brodaty
authors: Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
authors: Bernhard T
authors: BT
authors: Baune
authors: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia; Department of Development Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney NSW, Australia.
authors: Julian N
authors: JN
authors: Trollor
authors: Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Randwick NSW, Australia; Neuropsychiatric Institute, Prince of Wales Hospital, Randwick NSW, Australia.
authors: Perminder S
authors: PS
authors: Sachdev
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D066128:Gray Matter / Q000473:pathology*; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D055436:Growth Differentiation Factor 15