title: Something in the air: hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy.
abstract: Recent clinical trials in cancer therapy have demonstrated unprecedented responses through blockade of CTLA-4 and PD-1 immune checkpoint pathways. In a provocative recent paper in Science Translational Medicine, Hatfield and colleagues demonstrate the ability of supplemental oxygen to act as a novel immune checkpoint inhibitor by disrupting the hypoxia-adenosine-A2aR pathway.
authors: Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors: Robert D
authors: RD
authors: Leone
authors: Pulmonary Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
authors: Maureen R
authors: MR
authors: Horton
authors: Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: poweljo@jhmi.edu.
authors: Jonathan D
authors: JD
authors: Powell
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology*; D010100:Oxygen / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D010100:Oxygen