title: Preclinical screening of anticancer drugs using infrared (IR) microspectroscopy.
abstract: High-throughput label-free technologies such as IR microscopy can objectively assess the effect of drugs upon cellular systems, offering the potential of a valuable preclinical tool that can aid in the drug development process.
authors: University of Manchester, Brunswick Street, Manchester M13 9PL, UK; WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK. Electronic address: caryn.hughes@manchester.ac.uk.
authors: Caryn
authors: C
authors: Hughes
authors: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK; Centre for Materials Science, Division of Chemistry, School of Forensic and Investigative Sciences, University of Central Lancashire (UCLan), Preston PR1 2HE, UK.
authors: Graeme
authors: G
authors: Clemens
authors: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow G1 1XL, UK. Electronic address: matthew.baker@strath.ac.uk.
authors: Matthew J
authors: MJ
authors: Baker
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008853:Microscopy / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents
keywords: biomarker; cancer; high-throughput; infrared; preclinical screening; spectroscopy