title: Diagnostic efficacy of magnifying endoscopy with narrow-band imaging for gastric neoplasms: a meta-analysis.
abstract: BACKGROUND
  Magnifying endoscopy with narrow-band imaging (ME-NBI) is a novel, image-enhanced endoscopic technique for differentiating gastrointestinal neoplasms and potentially enabling pathological diagnosis.
  
  
  OBJECTIVE
  The aim of this analysis was to assess the diagnostic performance of ME-NBI for gastric neoplasms.
  
  
  METHODS
  We performed a systematic search of the PubMed, EMbase, Web of Science, and Cochrane Library databases for relevant studies. Meta-DiSc (version 1.4) and STATA (version 11.0) software were used for the data analysis. Random effects models were used to assess diagnostic efficacy. Heterogeneity was tested by the Q statistic and I2 statistic. Meta-regression was used to analyze the sources of heterogeneity.
  
  
  RESULTS
  A total of 10 studies, with 2151 lesions, were included. The pooled characteristics of these studies were as follows: sensitivity 0.85 (95% confidence interval [CI]: 0.81-0.89), specificity 0.96 (95% confidence interval [CI]: 0.95-0.97), and area under the curve (AUC) 0.9647. In the subgroup analysis, which compared the diagnostic efficacy of ME-NBI and white light imaging (WLI), the pooled sensitivity and specificity of ME-NBI were 0.87 (95% CI: 0.80-0.92) and 0.93 (95% CI: 0.90-0.95), respectively, and the area under the curve (AUC) was 0.9556. In contrast, the pooled sensitivity and specificity of WLI were 0.61 (95% CI: 0.53-0.69) and 0.65 (95% CI: 0.60-0.69), respectively, and the area under the curve (AUC) was 0.6772.
  
  
  CONCLUSIONS
  ME-NBI presents a high diagnostic value for gastric neoplasms and has a high specificity.
authors: Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors: Xiuhe
authors: X
authors: Lv
authors: Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors: Chunhui
authors: C
authors: Wang
authors: Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors: Yan
authors: Y
authors: Xie
authors: Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors: Zhaoping
authors: Z
authors: Yan
mesh_terms: D003952:Diagnostic Imaging; D004724:Endoscopy / Q000379:methods*; D006801:Humans; D062048:Narrow Band Imaging / Q000379:methods*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology