title: Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary disease.
abstract: BACKGROUND
  Chronic obstructive pulmonary disease causes significant morbidity and concomitant pulmonary vascular disease and cardiac dysfunction are associated with poor prognosis. Computed tomography-detected relative pulmonary artery (PA) enlargement defined as a PA to ascending aorta diameter ratio >1 (PA:A>1) is a marker for pulmonary hypertension and predicts chronic obstructive pulmonary disease exacerbations. However, little is known about the relationship between the PA:A ratio, pulmonary blood volume, and cardiac function.
  
  
  RESULTS
  A single-center prospective cohort study of patients with chronic obstructive pulmonary disease was conducted. Clinical characteristics and computed tomography metrics, including the PA:A and pulmonary blood vessel volume, were measured. Ventricular functions, volumes, and dimensions were measured by cine cardiac MRI with 3-dimensional analysis. Linear regression examined the relationships between clinical characteristics, computed tomography and cardiac MRI metrics, and 6-minute walk distance. Twenty-four patients were evaluated and those with PA:A>1 had higher right ventricular (RV) end-diastolic and end-systolic volume indices accompanied by lower RV ejection fraction (52±7% versus 60±9%; P=0.04). The PA:A correlated inversely with total intraparenchymal pulmonary blood vessel volume and the volume of distal vessels with a cross-sectional area of <5 mm(2). Lower forced expiratory volume, PA:A>1, and hyperinflation correlated with reduced RV ejection fraction. Both PA diameter and reduced RV ejection fraction were independently associated with reduced 6-minute walk distance.
  
  
  CONCLUSIONS
  The loss of blood volume in distal pulmonary vessels is associated with PA enlargement on computed tomography. Cardiac MRI detects early RV dysfunction and remodeling in nonsevere chronic obstructive pulmonary disease patients with a PA:A>1. Both RV dysfunction and PA enlargement are independently associated with reduced walk distance.
  
  
  BACKGROUND
  URL: http://www.clinicaltrials.gov. Unique identifier: NCT00608764.
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.). jmwells@uab.edu.
authors: J Michael
authors: JM
authors: Wells
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: Anand S
authors: AS
authors: Iyer
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: Farbod N
authors: FN
authors: Rahaghi
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: Surya P
authors: SP
authors: Bhatt
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: Himanshu
authors: H
authors: Gupta
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: Thomas S
authors: TS
authors: Denney
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: Steven G
authors: SG
authors: Lloyd
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: Louis J
authors: LJ
authors: Dell'Italia
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: Hrudaya
authors: H
authors: Nath
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: Raul San Jose
authors: RS
authors: Estepar
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: George R
authors: GR
authors: Washko
authors: From the Birmingham VA Medical Center, AL (J.M.W., H.G., S.G.L., L.J.D., M.T.D.); Department of Medicine (J.M.W., A.S.I., S.P.B., H.G., S.G.L., L.J.D., M.T.D.), Division of Pulmonary, Allergy, and Critical Care, Lung Health Center (J.M.W., S.P.B., M.T.D.), Division of Cardiovascular Disease (H.G., S.G.L., L.J.D.), and Department of Radiology (H.N.), University of Alabama at Birmingham; Division of Pulmonary and Critical Care Medicine (F.N.R., G.R.W.) and Department of Radiology, Harvard Medical School (R.S.J.E.), Brigham and Women's Hospital, Boston, MA; and Department of Electrical and Computer Engineering, Auburn University, AL (T.S.D.).
authors: Mark T
authors: MT
authors: Dransfield
mesh_terms: D000368:Aged; D001810:Blood Volume; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000473:pathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology* / Q000503:physiopathology*; D018497:Ventricular Dysfunction, Right / Q000473:pathology*
keywords: cardiac magnetic resonance imaging; hypertension, pulmonary; pulmonary disease; pulmonary heart disease; smoking