title: [Anti-Candida activity of aroma candy and its protective activity against murine oral candidiasis].
abstract: A daily eatable candy that has possible protective activity against oral candidiasis was experimentally produced. The candy was made from reduced-maltose as main constituent and from several natural products, such as oligonol (depolymerized polyphenols derived from lychee), cinnamon (cassia), citral, and capric acid, which are known to have anti-Candida activity in vitro and in vivo. The candy effectively inhibited the mycelial growth of C. albicans, even when it was diluted 1,000 times with culture media. We assessed the protective activity of the candy against murine candidiasis. When 50μl of candy dissolved and diluted 4 times with water was administered 3 times into the oral cavity of Candida infected mice, the score of lesions on the Candida-infected tongues improved on day 2. These findings suggest that this candy has potential as food that provides protective activity against oral candidiasis.
authors: Teikyo University Institute of Medical Mycology.
authors: Kazumi
authors: K
authors: Hayama
authors: Miki
authors: M
authors: Takahashi
authors: Motofumi
authors: M
authors: Suzuki
authors: Kunio
authors: K
authors: Ezawa
authors: Masatoshi
authors: M
authors: Yamazaki
authors: Taiji
authors: T
authors: Matsukawa
authors: Akinobu
authors: A
authors: Kishi
authors: Nobuya
authors: N
authors: Sato
authors: Shigeru
authors: S
authors: Abe
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000188:drug therapy* / Q000382:microbiology* / Q000517:prevention & control; D002182:Candy; D002366:Cassia / Q000737:chemistry*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D029745:Codonopsis / Q000737:chemistry; D003652:Decanoic Acids / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004338:Drug Combinations; D025141:Drug Resistance, Fungal; D005227:Fatty Acids / Q000494:pharmacology / Q000627:therapeutic use; D006035:Glycyrrhiza / Q000737:chemistry; D008320:Maltose / Q000031:analogs & derivatives; D051379:Mice; D008813:Mice, Inbred ICR; D039821:Monoterpenes / Q000494:pharmacology* / Q000627:therapeutic use; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D059808:Polyphenols / Q000494:pharmacology* / Q000627:therapeutic use; D011429:Propolis; D013047:Specific Pathogen-Free Organisms; D013213:Starch; D013402:Sugar Alcohols; D016896:Treatment Outcome; D000099219:Royal Jelly
chemical_list: D000080462:Acyclic Monoterpenes; D002392:Catechin; D003652:Decanoic Acids; D004338:Drug Combinations; D005227:Fatty Acids; D008320:Maltose; D039821:Monoterpenes; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D011429:Propolis; D013213:Starch; D013402:Sugar Alcohols; D000099219:Royal Jelly; C514283:oligonol; C031071:decanoic acid; C010745:maltitol; C007076:citral