title: Gene expression profiling and regression rate of irradiated uveal melanomas.
abstract: OBJECTIVE
  Uveal melanoma is the most common primary intraocular cancer; however, the molecular features that predict response to therapy are poorly understood. Our objective was to determine whether gene expression profiling (GEP) is associated with rate of tumor regression after I-125 plaque brachytherapy for uveal melanoma.
  
  
  METHODS
  Retrospective review of 138 patients with posterior uveal melanoma treated with I-125 plaque brachytherapy in which GEP class and 3-month post-radiation ultrasonographic tumor thickness data were available. Statistical analysis was performed using t test and Fisher's exact test.
  
  
  RESULTS
  GEP class assignment was class 1 in 83 (60.1%) and class 2 in 55 (39.9%) patients. Mean patient age was 60.9 years for class 1 and 68.1 years for class 2 tumors (P = .002). Mean initial tumor diameter was 13.0 mm for class 1 and 14.1 mm for class 2 tumors (P = .02). Mean initial tumor thickness was 5.2 mm for class 1 and 6.1 mm for class 2 tumors (P = .047). Three months after I-125 plaque radiotherapy, mean reduction in tumor thickness was 26.5% for class 1 and 16.7% for class 2 tumors (P = .03).
  
  
  CONCLUSIONS
  Class 1 uveal melanoma tumors exhibit more rapid early tumor regression than class 2 tumors after I-125 plaque radiotherapy.
authors: Rajesh C
authors: RC
authors: Rao
authors: Mehnaz
authors: M
authors: Khan
authors: Shahed N
authors: SN
authors: Badiyan
authors: J William
authors: JW
authors: Harbour
mesh_terms: D000368:Aged; D001918:Brachytherapy; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D014604:Uveal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy*; D000098943:Uveal Melanoma
chemical_list: D004273:DNA, Neoplasm; D007457:Iodine Radioisotopes; D009363:Neoplasm Proteins