title: Histopathological and immunohistochemical features of atypical epithelial tumours of the gland of the third eyelid in seven dogs.
abstract: This report documents the histopathological and immunohistochemical features of atypical epithelial tumours of the gland of the third eyelid (GTE) in seven dogs. Cases 1 and 2 were diagnosed as myoepithelioma, comprising of compressive proliferations of interlacing bundles of neoplastic spindle cells expressing cytokeratin 14, p63, calponin and α-smooth muscle actin. Cases 3, 4 and 5 were diagnosed as complex carcinomas comprising of atypical glandular cells expressing cytokeratin 8/18, together with spindle-shaped or round neoplastic cells expressing cytokeratin 14, p63, calponin and α-smooth muscle actin. Cases 6 and 7 were diagnosed as basal cell adenocarcinomas (BCACs) comprising of a mixed proliferation of glandular and basal-type cells expressing cytokeratin 14 and p63. Therefore, in addition to glandular components, these tumours may include neoplastic cells with a myoepithelial or basal cell phenotype. Hence, there is diversity in the features of epithelial neoplasia of the GTE in dogs, similar to tumours in human salivary and lacrimal glands.
authors: Laboratory of Veterinary Pathology, Gifu University, 1-1 Yanagido, Gifu, Japan.
authors: A
authors: A
authors: Miyazaki
authors: Laboratory of Veterinary Pathology, Gifu University, 1-1 Yanagido, Gifu, Japan; Comparative Cancer Center, Gifu University, 1-1 Yanagido, Gifu, Japan.
authors: K
authors: K
authors: Yonemaru
authors: Laboratory of Veterinary Pathology, Gifu University, 1-1 Yanagido, Gifu, Japan; Comparative Cancer Center, Gifu University, 1-1 Yanagido, Gifu, Japan; Division of Animal Experimentation, Gifu University, 1-1 Yanagido, Gifu, Japan.
authors: A
authors: A
authors: Hirata
authors: Laboratory of Veterinary Pathology, Gifu University, 1-1 Yanagido, Gifu, Japan.
authors: T
authors: T
authors: Yanai
authors: Laboratory of Veterinary Pathology, Gifu University, 1-1 Yanagido, Gifu, Japan; Comparative Cancer Center, Gifu University, 1-1 Yanagido, Gifu, Japan. Electronic address: shiroki@gifu-u.ac.jp.
authors: H
authors: H
authors: Sakai
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D005142:Eyelid Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008297:Male; D009208:Myoepithelioma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D009541:Nictitating Membrane / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: dog; epithelial tumour; third eyelid gland