title: [Relationship between vascular stenosis and cognition in leukoaraiosis patients].
abstract: OBJECTIVE
  To explore the relationship between the degree of vascular stenosis and cognition in leukoaraiosis patients.
  
  
  METHODS
  A total of 101 leukoaraiosis patients from the Department of Neurology, The First Affiliated Hospital of Anhui Medical University between September 2013 and June 2014, divided into two groups:patients with cognitive impairment (SVCI) (n = 54) , and those without cognitive impairment (NC) (n = 47) . All patients were enrolled and examined by magnetic resonance imaging (MRI) scanning and magnetic resonance angiography (MRA) or computed tomography angiography (CTA). The cognitive assessments were made by MMSE (mini-mental state examination), CAMCOG-C (Cambridge cognitive examination-Chinese version) and CDR (clinical dementia rating). The severity of leukoaraiosis and vascular stenosis was graded by MRI and MRA/CTA scans.
  
  
  RESULTS
  The degree of vascular stenosis group and the severity of LA in SVCI were significantly higher than NC (2.0 ± 0.8 vs1.1 ± 0.6, 2.6 ± 1.0 vs 2.0 ± 1.0; P = 0.020, P = 0.003). As white matter level aggravated, cognitive function decreased and vascular stenosis deteriorated accordingly, and the score of MMSE (25 ± 4, 24 ± 6, 22 ± 4) and CAMCOG-C (83 ± 14, 80 ± 14, 73 ± 14) has a statistical significance (P = 0.012, P = 0.014). At the same time, the negative correlation was found in LA patients between cognitive function and severity of LA (r = -0.317, P = 0.001) as well as degree of vascular stenosis (r = -0.284, P = 0.004). Multivariate Logistic regression analysis revealed that, after controlling for various factors, both severity of LA (OR = 2.025, 95% CI 1.307-3.954) and the degree of vascular stenosis (OR = 1.812, 95% CI 1.129-2.908) were risk factors for cognitive impairment in leukoaraiosis patients.
  
  
  CONCLUSIONS
  Cognition of leukoaraiosis patients is correlated with both severity of leukoaraiosis and vascular stenosis.
authors: Department of Neurology, First Affiliated Hospital, Anhui Medicial University, Hefei 230022, China.
authors: Chao
authors: C
authors: Zhang
authors: Department of Neurology, First Affiliated Hospital, Anhui Medicial University, Hefei 230022, China.
authors: Xia
authors: X
authors: Zhou
authors: Department of Neurology, First Affiliated Hospital, Anhui Medicial University, Hefei 230022, China.
authors: Long
authors: L
authors: Wang
authors: Department of Neurology, First Affiliated Hospital, Anhui Medicial University, Hefei 230022, China.
authors: Han
authors: H
authors: Liu
authors: Department of Neurology, First Affiliated Hospital, Anhui Medicial University, Hefei 230022, China.
authors: Minmin
authors: M
authors: Zhu
authors: Department of Neurology, First Affiliated Hospital, Anhui Medicial University, Hefei 230022, China. Email: sunzhwu@hotmail.com.
authors: Zhongwu
authors: Z
authors: Sun
mesh_terms: D003071:Cognition; D003072:Cognition Disorders; D003251:Constriction, Pathologic; D003704:Dementia; D006801:Humans; D049292:Leukoaraiosis; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D012307:Risk Factors; D066127:White Matter