title: Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer.
abstract: The role of manganese-dependent superoxide dismutase (SOD2/MnSOD) during tumor progression has been studied for several decades with controversial results. While SOD2 downregulation was initially associated with tumor initiation and was proposed as a tumor suppressor gene, recent studies have reported that SOD2 might favor tumor progression and dissemination. To our knowledge this is the first time that changes in SOD2 expression in three different types of tumors, i.e., prostate, lung, and colon cancer, are studied by analyzing both SOD2 mRNA and protein levels in a total of 246 patients' samples. In prostate samples, SOD2 protein levels were also increased, especially in middle stage tumors. In the case of colon and lung tumors both mRNA and protein SOD2 levels were increased in malignant tissues compared to those in nontumor samples. More importantly, all metastases analyzed showed increased levels of SOD2 when compared to those of normal primary tissue and healthy adjacent tissue. Together, these results suggest that a common redox imbalance in these three types of tumor occurs at intermediate stages which then might favor migration and invasion, leading to a more aggressive cancer type. Consequently, the ratios SOD2/catalase and SOD2/Gpx1 could be considered as potential markers during progression from tumor growth to metastasis.
authors: Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, University of Oviedo, Spain; Instituto Universitario Oncológico del Principado de Asturias (IUOPA), Oviedo, Spain.
authors: Ana
authors: A
authors: Miar
authors: Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, University of Oviedo, Spain; Instituto Universitario Oncológico del Principado de Asturias (IUOPA), Oviedo, Spain.
authors: David
authors: D
authors: Hevia
authors: Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, University of Oviedo, Spain.
authors: Henar
authors: H
authors: Muñoz-Cimadevilla
authors: Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, University of Oviedo, Spain; Department of Pathology, Hospital Universitario Central de Asturias, Oviedo, Spain.
authors: Aurora
authors: A
authors: Astudillo
authors: Department of Pathology, Hospital de San Agustin, Aviles, Spain.
authors: Julio
authors: J
authors: Velasco
authors: Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, University of Oviedo, Spain; Instituto Universitario Oncológico del Principado de Asturias (IUOPA), Oviedo, Spain. Electronic address: sainzrosa@uniovi.es.
authors: Rosa M
authors: RM
authors: Sainz
authors: Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, University of Oviedo, Spain; Instituto Universitario Oncológico del Principado de Asturias (IUOPA), Oviedo, Spain. Electronic address: mayojuan@uniovi.es.
authors: Juan C
authors: JC
authors: Mayo
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000201:enzymology / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000473:pathology*; D008297:Male; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000473:pathology*; D012333:RNA, Messenger / Q000235:genetics; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D000094765:Glutathione Peroxidase GPX1; D000099156:Superoxide Dismutase 2
chemical_list: D014408:Biomarkers, Tumor; D002374:Catalase; D005979:Glutathione Peroxidase; D012333:RNA, Messenger; D013482:Superoxide Dismutase; D000094765:Glutathione Peroxidase GPX1; D000099156:Superoxide Dismutase 2; C000722067:GPX1 protein, human
keywords: Catalase; Colon cancer; Glutathione; Hydrogen peroxidase; Lung cancer; Peroxidase; Prostate cancer; Redox state; SOD2