title: Intrahepatic Cholangiocarcinoma With Lymphoepithelioma-like Carcinoma Components Not Associated With Epstein-Barr Virus: Report of a Case.
abstract: A carcinoma displaying undifferentiated features with dense lymphoplasmacytic infiltration is defined as lymphoepithelioma-like carcinoma (LELC). Intrahepatic cholangiocarcinoma (ICC) with LELC components is rare, and most LELCs are associated with Epstein-Barr virus (EBV). We report here on a case of ICC with LELC components not associated with EBV. A 65-year-old woman was incidentally found to have a hepatic tumor in the caudate lobe. An extended right hepatectomy with lymphadenectomy was performed. Histologically, the tumor was mainly composed of large undifferentiated epithelial cells with vesicular nuclei, prominent nucleoli, indistinct cell borders, and heavy small lymphocytic infiltration, which are the characteristic features of LELC. Immunohistochemical studies revealed that the tumor cells were positive for cytokeratin 19 but were negative for glypican 3. In situ hybridization using EBV-encoded RNA was negative. Therefore, a diagnosis of ICC with LELC components not associated with EBV was made. Because there is limited information available regarding the prognosis and treatment of ICC with LELC components because of the limited number of reported cases, additional studies will be needed to clarify the clinicopathologic features of this disease.
authors: 1 Department of Surgery, National Defense Medical College, Saitama, Japan.
authors: Suefumi
authors: S
authors: Aosasa
authors: Tadashi
authors: T
authors: Maejima
authors: Akifumi
authors: A
authors: Kimura
authors: Kiyoshi
authors: K
authors: Nishiyama
authors: Hiromi
authors: H
authors: Edo
authors: Hiroshi
authors: H
authors: Shinmoto
authors: Tatsumi
authors: T
authors: Kaji
authors: Sho
authors: S
authors: Ogata
authors: Kazuo
authors: K
authors: Hatsuse
authors: Kazuo
authors: K
authors: Hase
authors: Junji
authors: J
authors: Yamamoto
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology* / Q000601:surgery*; D001653:Bile Ducts, Intrahepatic; D014408:Biomarkers, Tumor / Q000032:analysis; D018281:Cholangiocarcinoma / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D033162:Incidental Findings; D008197:Lymph Node Excision
chemical_list: D014408:Biomarkers, Tumor
keywords: Cholangiocarcinoma; Epstein-Barr virus; Liver; Lymphoepithelioma-like carcinoma