title: Polyfluorinated groups in medicinal chemistry.
abstract: Introduction of novel and diverse functional groups in drug discovery is always seen with hesitancy until good activity and low toxicity characteristics are proven. The introduction of fluorine in drug-like compounds is now a well-accepted strategy in medicinal chemistry. However, polyfluoroalkyl groups, with the exception of trifluoromethyl substituents, are not well explored yet. Our aim is to show to the readers how polyfluorinated groups can be beneficial to the properties of pharmaceutically active compounds by highlighting the structure-activity relationship (SAR) studies that led to the selection of polyfluorinated moieties as key structural features. Despite the fact that the use of higher polyfluoroalkyl/aryl moieties is still in its infancy, we believe that they will soon acquire the same importance of their lower parents.
authors: School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edwards VII Avenue, Cardiff, United Kingdom.
authors: Marcella
authors: M
authors: Bassetto
authors: Salvatore
authors: S
authors: Ferla
authors: Fabrizio
authors: F
authors: Pertusati
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D005461:Fluorine / Q000737:chemistry; D005465:Fluorocarbon Polymers / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis; D011355:Prodrugs / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
chemical_list: D005465:Fluorocarbon Polymers; D004364:Pharmaceutical Preparations; D011355:Prodrugs; D005461:Fluorine