title: Co-delivery of baicalein and doxorubicin by hyaluronic acid decorated nanostructured lipid carriers for breast cancer therapy.
abstract: OBJECTIVE
  Combination anticancer therapy is promising to generate synergistic anticancer effects, to maximize the treatment effect and to overcome multi-drug resistance. Nanostructured lipid carriers (NLCs), composed of solid and liquid lipids, and surfactants are potentially good colloidal drug carriers. The aim of this study is to construct a hyaluronic acid (HA) decorated NLCs as nanocarriers for co-delivery baicalein (BCL) and doxorubicin (DOX).
  
  
  METHODS
  BCL- and DOX-loaded NLCs (BCL/DOX-NLCs) were prepared. HA ligands were used for the decoration of BCL/DOX-NLCs to form HA decorated BCL/DOX-NLCs (HA-BCL/DOX-NLCs). The in vitro cytotoxicity studies of different formulations were evaluated on DOX drug-resistant MCF-7 breast cancer cell line (MCF-7/ADR cells). In vivo anti-tumor effects were observed on the murine bearing MCF-7/ADR cells model.
  
  
  RESULTS
  HA-BCL/DOX-NLCs showed highest cytotoxicity and synergistic effect of two drugs in tumor cells in vitro. The in vivo study revealed the greatest anti-tumor activity than all the other formulations in the murine breast cancer model.
  
  
  CONCLUSIONS
  HA decorated NLCs could be used as a novel carrier to co-delivery BCL and DOX for breast cancer therapy. HA-BCL/DOX-NLCs could be a promising targeted and combinational therapy nanomedicine.
authors: a College of Pharmacy, Shandong University of Traditional Chinese Medicine , Ji'nan , Shandong , People's Republic of China .|b Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials , Ji'nan , Shandong , People's Republic of China , and.|c Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong , Ji'nan , Shandong , People's Republic of China.
authors: Qian
authors: Q
authors: Liu
authors: a College of Pharmacy, Shandong University of Traditional Chinese Medicine , Ji'nan , Shandong , People's Republic of China .|b Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials , Ji'nan , Shandong , People's Republic of China , and.|c Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong , Ji'nan , Shandong , People's Republic of China.
authors: Jia
authors: J
authors: Li
authors: a College of Pharmacy, Shandong University of Traditional Chinese Medicine , Ji'nan , Shandong , People's Republic of China .|b Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials , Ji'nan , Shandong , People's Republic of China , and.|c Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong , Ji'nan , Shandong , People's Republic of China.
authors: Gaobin
authors: G
authors: Pu
authors: a College of Pharmacy, Shandong University of Traditional Chinese Medicine , Ji'nan , Shandong , People's Republic of China .|b Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials , Ji'nan , Shandong , People's Republic of China , and.|c Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong , Ji'nan , Shandong , People's Republic of China.
authors: Fang
authors: F
authors: Zhang
authors: a College of Pharmacy, Shandong University of Traditional Chinese Medicine , Ji'nan , Shandong , People's Republic of China .|b Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials , Ji'nan , Shandong , People's Republic of China , and.|c Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong , Ji'nan , Shandong , People's Republic of China.
authors: Hongyan
authors: H
authors: Liu
authors: a College of Pharmacy, Shandong University of Traditional Chinese Medicine , Ji'nan , Shandong , People's Republic of China .|b Shandong Fine Breeding Engineering Research Center of Chinese Medicinal Materials , Ji'nan , Shandong , People's Republic of China , and.|c Key Laboratory of Resources Science of Chinese Medicinal Materials in University of Shandong , Ji'nan , Shandong , People's Republic of China.
authors: Yongqing
authors: Y
authors: Zhang
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000737:chemistry* / Q000188:drug therapy*; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D005260:Female; D044950:Flavanones / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry* / Q000494:pharmacology; D061986:MCF-7 Cells; D051379:Mice; D049329:Nanostructures
chemical_list: D004337:Drug Carriers; D044950:Flavanones; D008055:Lipids; C006680:baicalein; D004317:Doxorubicin; D006820:Hyaluronic Acid
keywords: Breast cancer; co-delivery; hyaluronic acid; nanostructured lipid carriers; surface decorated