title: Lifestyle modifications supported by regional health nurses lowered insulin resistance, oxidative stress and central blood pressure in subjects with metabolic syndrome.
abstract: BACKGROUND
  This study was attempted to investigate whether lifestyle modifications supported by regional health nurses should improve cardio-metabolic factors--including adipocytokines, oxidative stress, and arterial stiffness--in subjects with metabolic syndrome.
  
  
  METHODS
  Thirty-six subjects with metabolic syndrome were enrolled, 28 of whom completed the 6-month lifestyle modifications (male:female=19:9). Blood and urine test results were examined in relation to metabolic factors before and after 6-month nutritional and physical activity modifications. In addition, oral glucose tolerance tests were performed and arterial stiffness was measured by brachial-ankle pulse wave velocity and radial augmentation index before and after them.
  
  
  RESULTS
  Six-month lifestyle modifications significantly reduced body weight, homeostasis model assessment index, and low-density lipoprotein cholesterol (LDL-C). They significantly attenuated oxidative stress measured by the urinary 8-hydroxy-2-deoxyguanosine/creatinine ratio. They also lowered brachial and central systolic blood pressure. They tended to decrease waist circumferences and the levels of C-reactive protein. However they did not significantly change the levels of adipocytokines, including tumour necrosis factor, soluble tumour necrosis factor receptors, and interleukin 6, or arterial stiffness measured by brachial-ankle pulse wave velocity and radial augmentation index.
  
  
  CONCLUSIONS
  Six-month lifestyle modifications supported by regional health nurses lowered body weight, insulin resistance, LDL-C, oxidative stress, and peripheral and central blood pressure in subjects with metabolic syndrome.
authors: Community Health Science Center, Saitama Medical University, Saitama, Japan; Department of Nephrology, Saitama Medical University, Saitama, Japan. Electronic address: yo1-ohno@bk2.so-net.ne.jp.
authors: Yoichi
authors: Y
authors: Ohno
authors: Community Health Science Center, Saitama Medical University, Saitama, Japan.
authors: Takashi
authors: T
authors: Miyazaki
authors: Community Health Science Center, Saitama Medical University, Saitama, Japan.
authors: Makiko
authors: M
authors: Sato
authors: Community Health Science Center, Saitama Medical University, Saitama, Japan.
authors: Ryuichiro
authors: R
authors: Araki
authors: Community Health Science Center, Saitama Medical University, Saitama, Japan.
authors: Sachiko
authors: S
authors: Takahashi
authors: Clinical Research Center, International University of Health and Welfare, Tokyo, Japan.
authors: Tsuneo
authors: T
authors: Takenaka
authors: Community Health Science Center, Saitama Medical University, Saitama, Japan; Department of Nephrology, Saitama Medical University, Saitama, Japan.
authors: Hiromichi
authors: H
authors: Suzuki
authors: Community Health Science Center, Saitama Medical University, Saitama, Japan.
authors: Satomi
authors: S
authors: Shibazaki
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D037001:Directive Counseling / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000451:nursing* / Q000503:physiopathology* / Q000628:therapy; D008875:Middle Aged; D018384:Oxidative Stress; D011637:Public Health Nursing / Q000458:organization & administration*; D012040:Regional Health Planning / Q000458:organization & administration*; D012307:Risk Factors; D040242:Risk Reduction Behavior; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein
keywords: Blood pressure; Insulin resistance; Lifestyle modifications; Metabolic syndrome; Oxidative stress