title: Reliability and validity of the perfusion, extent, depth, infection and sensation (PEDIS) classification system and score in patients with diabetic foot ulcer.
abstract: OBJECTIVE
  To validate the perfusion, extent, depth, infection and sensation (PEDIS) classification system and to make the clinical practice easier, we created a score system and compared this system with two previously published common score systems.
  
  
  METHODS
  A retrospective cohort study was conducted on patients with diabetic foot ulcer (DFU) attending our hospital (n=364) from May 2007 to September 2013. Participants' characteristics and all variables composing the PEDIS classification system were assessed.
  
  
  RESULTS
  During a median follow-up of 25 months (range 6-82), ulcers healed in 217 of the 364 patients (59.6%), remained unhealed in 37 patients (10.2%), and were resolved by amputation in 62 patients (17.0%); 48 patients (13.2%) died. When measured using the PEDIS classification system, the outcome of DFU deteriorated with increasing severity of each subcategory. Additionally, longer ulcer history, worse perfusion of lower limb, a larger extent of the ulcer, a deeper wound, more severe infection, and loss of protective sensation were independent predictors of adverse outcome. More importantly, the new PEDIS score system showed good diagnostic accuracy, especially when compared with the SINBAD and Wagner score systems.
  
  
  CONCLUSIONS
  The PEDIS classification system, which encompasses relevant variables that contribute to the outcome of DFU and has excellent capacity for predicting the ulcer outcome, demonstrated acceptable accuracy. The PEDIS classification system might be useful in clinical practice and research both for the anticipation of health care costs and for comparing patient subgroups.
authors: Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors: Fengning
authors: F
authors: Chuan
authors: Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors: Kang
authors: K
authors: Tang
authors: Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors: Peng
authors: P
authors: Jiang
authors: Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors: Bo
authors: B
authors: Zhou
authors: Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors: Xiaoqun
authors: X
authors: He
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D017719:Diabetic Foot / Q000145:classification* / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D007239:Infections / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D010477:Perfusion; D012189:Retrospective Studies; D012677:Sensation / Q000502:physiology*; D055815:Young Adult