title: Preparation of tertiary amines by the reaction of iminium ions derived from unsymmetrical aminals with zinc and magnesium organometallics.
abstract: We report a convenient one-pot preparation of polyfunctional tertiary amines, including various biorelevant phenethylamines or ephedrine derivatives, via the reaction of new functionalized iminium ions with a variety of zinc and magnesium organometallic reagents. These iminium ions were generated from unsymmetrical aminals, obtained by the in situ addition of various amides to Tietze's iminium salt [Me2NCH2(+)CF3COO(-)]. A functionalized aniline, prepared by this method, was converted to a quinolidine via an intramolecular Heck reaction.
authors: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany.
authors: Veronika
authors: V
authors: Werner
authors: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany.
authors: Mario
authors: M
authors: Ellwart
authors: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany.
authors: Andreas J
authors: AJ
authors: Wagner
authors: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich, Germany.
authors: Paul
authors: P
authors: Knochel