title: [Association between perioperative bleeding post percutaneous coronary intervention and 1 year clinical outcomes in elderly patients].
abstract: OBJECTIVE
  To evaluate the association between perioperative bleeding post percutaneous coronary intervention (PCI) and 1 year adverse cardiovascular events in elderly patients.
  
  
  METHODS
  From June 2006 to August 2011, 1 105 elderly ( ≥ 75 years) patients undergoing PCI in Fuwai Hospital were prospectively included. Patients were divided into peri-procedure bleeding group (n = 153) and no bleeding group (n = 952). Cox proportional hazards model was performed to evaluate the independent effect of bleeding on the composite endpoint of death and myocardial infarction.
  
  
  RESULTS
  BARC 2 grade bleeding occurred in 9.5% (105/1 105) patients. The rate of BARC ≥ 2 grade bleeding was 11.8% (130/1 105) , and the access site-related bleeding accounted for 62.7% (96/153) of all bleeding. The composite endpoint of 1 year death and myocardial infarction was higher in bleeding group (9.2% (14/153) vs. 4.2% (40/952), P = 0.008) . The 1 year cardiac death was higher in bleeding group (3.9% (6/153) vs. 0.8% (8/952), P = 0.007), but the rate of non-cardiac death was similar between bleeding group and no bleeding group (P = 0.360). Cox proportional hazards model analysis showed that HR of 1 year death and myocardial infarction in BARC ≥ 2 grade bleeding patients was 2.368 (95%CI:1.201-4.669, P = 0.013) compared with no bleeding patients.
  
  
  CONCLUSIONS
  Perioperative bleeding post PCI is an independent predictor of 1 year adverse outcomes in elderly patients( ≥ 75 years).
authors: Coronary Heart Disease Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors: Peiyuan
authors: P
authors: He
authors: Yuejin
authors: Y
authors: Yang
authors: Shubin
authors: S
authors: Qiao
authors: Bo
authors: B
authors: Xu
authors: Min
authors: M
authors: Yao
authors: Yongjian
authors: Y
authors: Wu
authors: Jinqing
authors: J
authors: Yuan
authors: Jue
authors: J
authors: Chen
authors: Yuan
authors: Y
authors: Wu
authors: Haibo
authors: H
authors: Liu
authors: Jun
authors: J
authors: Dai
authors: Wei
authors: W
authors: Li
authors: Yida
authors: Y
authors: Tang
authors: Jingang
authors: J
authors: Yang
authors: Runlin
authors: R
authors: Gao
mesh_terms: D000368:Aged; D006470:Hemorrhage; D006801:Humans; D009203:Myocardial Infarction; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D016896:Treatment Outcome