title: Distribution of lymphocyte subpopulations in patients with polycythemia vera.
abstract: Polycythemia vera (PV) is a disease with slow development. Nonetheless, the immune response is unable to eliminate the uncontrolled proliferating hematopoietic cells, leading to treatment of patient by phlebotomy and/or cytotoxic drugs. In addition, a higher incidence of cancers is observed in PV patients, independently of treatment. These observations argue for an impaired immune response in PV. In order to investigate this hypothesis, we studied the distribution of lymphocyte subpopulations in PV, and showed a significant decrease in T, TCR γ/δ and B cells together with an increase in natural killer (NK) cells.
authors: APHM, Laboratoire d'Hématologie, Hôpital Nord, Marseille, France; Aix-Marseille Univ, U1090, TAGC, 13008 Marseille, France.
authors: Carole
authors: C
authors: Sanchez
authors: APHM, Laboratoire d'Hématologie, Hôpital Nord, Marseille, France.
authors: Thérèse
authors: T
authors: Le Treut
authors: Aix-Marseille Univ, U1090, TAGC, 13008 Marseille, France.
authors: Céline
authors: C
authors: Baier
authors: APHM, Laboratoire d'Hématologie, Hôpital Nord, Marseille, France; Service d'Hématologie, CHU La Conception, Marseille, France.
authors: Gérard
authors: G
authors: Sébahoun
authors: Aix-Marseille Univ, U1090, TAGC, 13008 Marseille, France; Service d'Hématologie, CHU La Conception, Marseille, France. Electronic address: regis.costello@free.fr.
authors: Régis T
authors: RT
authors: Costello
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D006801:Humans; D016130:Immunophenotyping; D053614:Janus Kinase 2 / Q000235:genetics / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011087:Polycythemia Vera / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta; C507924:JAK2 protein, human; D053614:Janus Kinase 2
keywords: Lymphocytes; Natural killer cells; Polycythemia vera