title: Associations between pentraxin 3 and severity of coronary artery disease.
abstract: OBJECTIVE
  To investigate the associations between plasma levels of pentraxins 3 (PTX3) and C reactive protein (CRP) and the severity of coronary artery lesions.
  
  
  METHODS
  60 patients with coronary heart disease (CHD) who underwent coronary angiography (CAG) in our hospital were included. Plasma was collected during CAG. The coronary Gensini score was used to evaluate the severity of coronary artery lesions. Associations between Gensini scores and plasma levels of PTX3 and CRP were analysed. Patients with estimated glomerular filtration rate <60 mL/min/1.73 m(2) were included in the chronic renal dysfunction subgroup.
  
  
  RESULTS
  A linear correlation was observed between PTX3 and the Gensini score (r=0.513, p<0.001). One-way analysis of variance showed that PTX3 levels were significantly higher in patients with Gensini scores >90 compared with patients with scores of 46-90 or <45 (0-45:4.8±0.8, 46-90:6.7±1.2, >90:7.7±2.0, p<0.001). Stepwise multiple linear regression showed that PTX3 levels were significantly associated with Gensini score in patients with chronic renal dysfunction (p=0.012), while no significant association was found for CRP.
  
  
  CONCLUSIONS
  PTX3 levers were positively associated with the severity of coronary artery lesions. PTX3 is closely associated with the severity of coronary artery stenosis in patients with chronic renal dysfunction.
authors: Department of Cardiology, Shanghai Chest Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai, China.
authors: Hua
authors: H
authors: Liu
authors: Department of Cardiology, Shanghai Chest Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai, China.
authors: Shaofeng
authors: S
authors: Guan
authors: Department of Cardiology, Shanghai Chest Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai, China.
authors: Weiyi
authors: W
authors: Fang
authors: Department of Cardiology, Shanghai Chest Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai, China.
authors: Fang
authors: F
authors: Yuan
authors: Department of Cardiology, Shanghai Chest Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai, China.
authors: Min
authors: M
authors: Zhang
authors: Department of Cardiology, Shanghai Chest Hospital, Affiliated to Shanghai Jiao Tong University, Shanghai, China.
authors: Xinkai
authors: X
authors: Qu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism*; D015331:Cohort Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D023921:Coronary Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism*; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D012720:Severity of Illness Index; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins