title: Pathogenic microbes manipulate cofilin activity to subvert actin cytoskeleton.
abstract: Actin-depolymerizing factor (ADF)/cofilin proteins are key players in controlling the temporal and spatial extent of actin dynamics, which is crucial for mediating host-pathogen interactions. Pathogenic microbes have evolved molecular mechanisms to manipulate cofilin activity to subvert the actin cytoskeletal system in host cells, promoting their internalization into the target cells, modifying the replication niche and facilitating their intracellular and intercellular dissemination. The study of how these pathogens exploit cofilin pathways is crucial for understanding infectious disease and providing potential targets for drug therapies.
authors: a Department of Pharmacy, School of Medicine , Shenzhen University , Shenzhen , Guangdong , People's Republic of China .|c Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University , Guangzhou , China.
authors: Kai
authors: K
authors: Zheng
authors: b Division of Molecular Pharmacology of Infectious Agents, Department of Molecular Microbiology and Immunology , Nagasaki University , Nagasaki , Japan , and.
authors: Kaio
authors: K
authors: Kitazato
authors: c Guangzhou Jinan Biomedicine Research and Development Center, National Engineering Research Center of Genetic Medicine, Jinan University , Guangzhou , China.
authors: Yifei
authors: Y
authors: Wang
authors: a Department of Pharmacy, School of Medicine , Shenzhen University , Shenzhen , Guangdong , People's Republic of China .
authors: Zhendan
authors: Z
authors: He
mesh_terms: D008841:Actin Cytoskeleton / Q000235:genetics / Q000378:metabolism*; D051339:Actin Depolymerizing Factors / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001419:Bacteria / Q000235:genetics; D001424:Bacterial Infections / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology*; D018407:Bacterial Physiological Phenomena; D051345:Destrin / Q000235:genetics / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans
chemical_list: D051339:Actin Depolymerizing Factors; D051345:Destrin
keywords: Actin-based motility; actin cytoskeleton; cofilin; entry; pathogen infection