title: Novel Cosic resonance (standing wave) solutions for components of the JAK-STAT cellular signaling pathway: A convergence of spectral density profiles.
abstract: Cosic discovered that spectral analyses of a protein sequence after each constituent amino acid had been transformed into an appropriate pseudopotential predicted a resonant energy between interacting molecules. Several experimental studies have verified the predicted peak wavelength of photons within the visible or near-visible light band for specific molecules. Here, this concept has been applied to a classic signaling pathway, JAK-STAT, traditionally composed of nine sequential protein interactions. The weighted linear average of the spectral power density (SPD) profiles of each of the eight "precursor" proteins displayed remarkable congruence with the SPD profile of the terminal molecule (CASP-9) in the pathway. These results suggest that classic and complex signaling pathways in cells can also be expressed as combinations of resonance energies.
authors: Biomolecular Sciences Program, Bioquantum Chemistry Laboratory, Laurentian University , Sudbury, Ontario P3E 2C6, Canada.
authors: Lukasz M
authors: LM
authors: Karbowski
authors: Biomolecular Sciences Program, Bioquantum Chemistry Laboratory, Laurentian University , Sudbury, Ontario P3E 2C6, Canada.
authors: Nirosha J
authors: NJ
authors: Murugan
authors: Biomolecular Sciences Program, Bioquantum Chemistry Laboratory, Laurentian University , Sudbury, Ontario P3E 2C6, Canada.
authors: Michael A
authors: MA
authors: Persinger
keywords: BCLxl, B-cell lymphoma-extra large; Bovine albumin; CASP-9, caspase 9; Cosic Resonance Recognition Model; EIIP, pseudopotential of electron–ion interaction; Il, interleukin; JAK, Janus Kinase; JAK–STAT; PBS, phosphate buffered saline; RRM, Resonance Recognition Model; SPD, spectral power density; STAT, Signal Transducer and Activator of Transcription; Signaling pathways; Spectral analysis; Tyk2, tyrosine kinase 2; cSrc, cellular Src kinase