title: Safety and efficacy of resolute zotarolimus-eluting stents compared with everolimus-eluting stents: a meta-analysis.
abstract: BACKGROUND
  Although new-generation drug-eluting stents represent the standard of care among patients undergoing percutaneous coronary intervention, there remains debate about differences in efficacy and the risk of stent thrombosis between the Resolute zotarolimus-eluting stent (R-ZES) and the everolimus-eluting stent (EES). The aim of this study was to evaluate the safety and efficacy of the R-ZES compared with EES in patients undergoing percutaneous coronary intervention.
  
  
  RESULTS
  A systematic literature search of electronic resources was performed using specific search terms until September 2014. Random-effects meta-analysis was performed comparing clinical outcomes between patients treated with R-ZES and EES up to maximum available follow-up. The primary efficacy end point was target-vessel revascularization. The primary safety end point was definite or probable stent thrombosis. Secondary safety end points were cardiac death and target-vessel myocardial infarction. Five trials were identified, including a total of 9899 patients. Compared with EES, R-ZES had similar risks of target-vessel revascularization (risk ratio [RR], 1.06; 95% confidence interval [CI], 0.90-1.24; P=0.50), definite or probable stent thrombosis (RR, 1.26; 95% CI, 0.86-1.85; P=0.24), cardiac death (RR, 1.01; 95% CI, 0.79-1.30; P=0.91), and target-vessel myocardial infarction (RR, 1.10; 95% CI, 0.89-1.36; P=0.39). Moreover, R-ZES and EES had similar risks of late definite or probable very late stent thrombosis (RR, 1.06; 95% CI, 0.53-2.11; P=0.87). No evidence of significant heterogeneity was observed across trials.
  
  
  CONCLUSIONS
  R-ZES and EES provide similar safety and efficacy among patients undergoing percutaneous coronary intervention.
authors: From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (R.P., G.G.S., A.F., E.S., S.B., S.W.); and Clinical Trials Unit (D.H., P.J., S.W.), Institute of Social and Preventive Medicine (D.H.), Institute of Primary Health Care (BIHAM) (P.J.), University of Bern, Bern, Switzerland.
authors: Raffaele
authors: R
authors: Piccolo
authors: From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (R.P., G.G.S., A.F., E.S., S.B., S.W.); and Clinical Trials Unit (D.H., P.J., S.W.), Institute of Social and Preventive Medicine (D.H.), Institute of Primary Health Care (BIHAM) (P.J.), University of Bern, Bern, Switzerland.
authors: Giulio G
authors: GG
authors: Stefanini
authors: From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (R.P., G.G.S., A.F., E.S., S.B., S.W.); and Clinical Trials Unit (D.H., P.J., S.W.), Institute of Social and Preventive Medicine (D.H.), Institute of Primary Health Care (BIHAM) (P.J.), University of Bern, Bern, Switzerland.
authors: Anna
authors: A
authors: Franzone
authors: From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (R.P., G.G.S., A.F., E.S., S.B., S.W.); and Clinical Trials Unit (D.H., P.J., S.W.), Institute of Social and Preventive Medicine (D.H.), Institute of Primary Health Care (BIHAM) (P.J.), University of Bern, Bern, Switzerland.
authors: Ernest
authors: E
authors: Spitzer
authors: From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (R.P., G.G.S., A.F., E.S., S.B., S.W.); and Clinical Trials Unit (D.H., P.J., S.W.), Institute of Social and Preventive Medicine (D.H.), Institute of Primary Health Care (BIHAM) (P.J.), University of Bern, Bern, Switzerland.
authors: Stefan
authors: S
authors: Blöchlinger
authors: From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (R.P., G.G.S., A.F., E.S., S.B., S.W.); and Clinical Trials Unit (D.H., P.J., S.W.), Institute of Social and Preventive Medicine (D.H.), Institute of Primary Health Care (BIHAM) (P.J.), University of Bern, Bern, Switzerland.
authors: Dik
authors: D
authors: Heg
authors: From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (R.P., G.G.S., A.F., E.S., S.B., S.W.); and Clinical Trials Unit (D.H., P.J., S.W.), Institute of Social and Preventive Medicine (D.H.), Institute of Primary Health Care (BIHAM) (P.J.), University of Bern, Bern, Switzerland.
authors: Peter
authors: P
authors: Jüni
authors: From the Department of Cardiology, Bern University Hospital, Bern, Switzerland (R.P., G.G.S., A.F., E.S., S.B., S.W.); and Clinical Trials Unit (D.H., P.J., S.W.), Institute of Social and Preventive Medicine (D.H.), Institute of Primary Health Care (BIHAM) (P.J.), University of Bern, Bern, Switzerland. stephan.windecker@insel.ch.
authors: Stephan
authors: S
authors: Windecker
mesh_terms: D054855:Drug-Eluting Stents / Q000009:adverse effects / Q000706:statistics & numerical data*; D000068338:Everolimus / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D062645:Percutaneous Coronary Intervention; D011183:Postoperative Complications / Q000401:mortality; D016032:Randomized Controlled Trials as Topic; D020123:Sirolimus / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D016019:Survival Analysis; D013927:Thrombosis / Q000209:etiology* / Q000401:mortality; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D000068338:Everolimus; C489443:zotarolimus; D020123:Sirolimus
keywords: everolimus-eluting stent; meta-analysis; randomized controlled trial; zotarolimus-eluting stent