title: Dietary soy isoflavones differentially regulate expression of the lipid-metabolic genes in different white adipose tissues of the female Bama mini-pigs.
abstract: Soy isoflavones have been shown to affect lipid metabolism, however the underlying molecular mechanism(s) have not yet been fully understood. The present study, using female Bama mini-pig as a model, examined the effects of soy isoflavones on lipid metabolism and involved gene expression in different white adipose tissues. Female Bama Xiang mini-pigs of 35 days old were fed a basal diet (control, Con), or basal diet supplemented with increasing amounts of soy isoflavones (250, 500, or 1250 mg/kg diet) for 120 days. The results showed that soy isoflavones did not affect the body weight, but decreased the dorsal subcutaneous adipose tissue (DSA) mass and increased the mass of abdominal subcutaneous adipose tissue (ASA) and perirenal adipose tissue (PRA). Besides, soy isoflavones decreased the expression of lipogenic genes and increased the expression of lipolytic genes in DSA, while the opposite effects were observed in ASA and PRA. In addition, the expression of lipoprotein lipase was down regulated in DSA while up regulated in ASA and PRA by soy isoflavones. Moreover, the expression of estrogen receptors (ERs) was up regulated in DSA, and down regulated in ASA and PRA by soy isoflavones. Our results suggest that soy isoflavones affected the lipid metabolism in white adipose tissues of Bama mini-pigs in a site-specific manner, which might be mediated through PPARs and ERs regulated gene expression.
authors: Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory for Agro-Ecological Processes of Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha 410125, China.
authors: Guoli
authors: G
authors: Jiang
authors: Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory for Agro-Ecological Processes of Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha 410125, China. Electronic address: lili@isa.ac.cn.
authors: Lili
authors: L
authors: Li
authors: Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory for Agro-Ecological Processes of Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha 410125, China; College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
authors: Juexin
authors: J
authors: Fan
authors: College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
authors: Bin
authors: B
authors: Zhang
authors: Department of Animal Nutrition, Federal University of Agriculture, P.M.B. 2240, Abeokuta, Ogun State, Nigeria.
authors: A O
authors: AO
authors: Oso
authors: Nutrition Research Division, Food Directorate, Health Canada, Ottawa, Ontario K1A0K9, Canada.
authors: Chaowu
authors: C
authors: Xiao
authors: Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center of Healthy Livestock, Key Laboratory for Agro-Ecological Processes of Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha 410125, China. Electronic address: yinyulong@isa.ac.cn.
authors: Yulong
authors: Y
authors: Yin
mesh_terms: D052436:Adipose Tissue, White / Q000187:drug effects / Q000378:metabolism*; D000284:Administration, Oral; D000818:Animals; D019587:Dietary Supplements; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D007529:Isoflavones / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects / Q000502:physiology*; D050155:Lipogenesis / Q000187:drug effects / Q000502:physiology; D008066:Lipolysis / Q000187:drug effects / Q000502:physiology; D055442:Metabolome / Q000187:drug effects / Q000502:physiology*; D013025:Glycine max / Q000737:chemistry*; D013552:Swine; D013556:Swine, Miniature
chemical_list: D007529:Isoflavones
keywords: Lipid metabolism; Mini-pigs; Soy isoflavones; White adipose tissues