title: Pseudohyperplastic variant of adenocarcinoma as a component of α-methyl-CoA-racemase (AMACR negative) carcinosarcoma of the prostate.
abstract: Carcinosarcoma (CS) or Sarcomatoid carcinoma (SC) of the prostate is a very rare malignant tumor of the prostate having an aggressive clinical course and dismal prognosis. The adenocarcinomatous element is usually of the acinar type and closely admixed with a sarcomatous component. We report a case of α-methyl-CoA-racemase (AMACR)-negative pseudohyperplastic variant of adenocarcinoma in CS. To the best of our knowledge, there have been no published case reports of this variant in CS till date. An accurate diagnosis is essential as this uncommon, aggressive cancer has limited therapeutic options.
authors: Department of Pathology, Army College of Medical Sciences and Base Hospital, Delhi Cantt, Delhi, India.
authors: Sharmila
authors: S
authors: Dudani
authors: Department of Pathology, Army College of Medical Sciences and Base Hospital, Delhi Cantt, Delhi, India.
authors: Ajay
authors: A
authors: Malik
authors: Department of Urology, Army College of Medical Sciences and Base Hospital, Delhi Cantt, Delhi, India.
authors: A S
authors: AS
authors: Sandhu
authors: Department of Pathology, Army College of Medical Sciences and Base Hospital, Delhi Cantt, Delhi, India.
authors: N S
authors: NS
authors: Mani
keywords: carcinosarcoma prostate; pseudohyperplastic variant; α-methyl–CoA-racemase