title: Resolution of Crohn's disease and complex regional pain syndrome following treatment of paratuberculosis.
abstract: A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP IgG in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been treated with a combination of anti-MAP antibiotics and ultraviolet blood irradiation therapy with resolution of the disease symptomatology and inability to culture MAP in post treatment blood samples. These case reports of patients with MAP infections provide supportive evidence of a pathogenic role of MAP in humans.
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: J Todd
authors: JT
authors: Kuenstner
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: William
authors: W
authors: Chamberlin
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: Saleh A
authors: SA
authors: Naser
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: Michael T
authors: MT
authors: Collins
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: Coad Thomas
authors: CT
authors: Dow
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: John M
authors: JM
authors: Aitken
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: Stuart
authors: S
authors: Weg
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: Grzegorz
authors: G
authors: Telega
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: Kuruvilla
authors: K
authors: John
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: David
authors: D
authors: Haas
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: Torsten M
authors: TM
authors: Eckstein
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: Maher
authors: M
authors: Kali
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: Christine
authors: C
authors: Welch
authors: J Todd Kuenstner, Department of Pathology, Charleston Area Medical Center, Charleston, WV 25304, United States.
authors: Thomas
authors: T
authors: Petrie
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001431:Bacteriological Techniques; D001706:Biopsy; D002648:Child; D003113:Colonoscopy; D003131:Combined Modality Therapy; D020918:Complex Regional Pain Syndromes / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D003424:Crohn Disease / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D016927:Mycobacterium avium subsp. paratuberculosis / Q000187:drug effects* / Q000302:isolation & purification / Q000528:radiation effects*; D010283:Paratuberculosis / Q000175:diagnosis / Q000382:microbiology / Q000628:therapy* / Q000635:transmission; D012074:Remission Induction; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000379:methods*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents
keywords: Complex regional pain syndrome; Crohn’s disease; Cure; Lymphangiomatosis; Mycobacterium avium paratuberculosis