title: Diffusion-weighted MRI findings and clinical correlations in sporadic Creutzfeldt-Jakob disease.
abstract: The objective of this study is to investigate the hyperintense lesions on diffusion-weighted magnetic resonance imaging (DWI) and its clinical correlation in sporadic Creutzfeldt-Jakob disease (sCJD). Patients who suffered from sCJD and followed up at the Department of Neurology at the General Hospital of the People's Liberation Army during the period of June 1, 2007 to July 1, 2014 were reviewed. The location of the hyperintense lesions on DWI, apparent diffusion coefficient (ADC) values of the hyperintense lesions were correlated with symptoms and clinical course. A total of 58 sCJD patients and ten healthy controls were included. Hyperintense lesions on DWI were observed in all the patients. The patients with basal ganglia (BG) hyperintense lesions on DWI had shorter disease duration and higher incidence of myoclonus (92 versus 44 %) than those without BG hyperintense lesions. The patients with occipital cortex hyperintense lesions on DWI had shorter disease duration between symptom onset and akinetic mutism than those without these lesions. The lower of the BG ADC value the faster presence of akinetic mutism and the shorter disease duration the patients will have. The presence of BG and occipital cortex hyperintense lesions on DWI and BG ADC values is correlated with the clinical course and clinical symptoms.
authors: Department of Neurology, Chinese People's Liberation Army General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China, angella_gao@163.com.
authors: Ting
authors: T
authors: Gao
authors: Jin-Hao
authors: JH
authors: Lyu
authors: Jia-Tang
authors: JT
authors: Zhang
authors: Xin
authors: X
authors: Lou
authors: Wei
authors: W
authors: Zhao
authors: Xiao-Wei
authors: XW
authors: Xing
authors: Ming
authors: M
authors: Yang
authors: Yan
authors: Y
authors: Yao
authors: Qing-Che
authors: QC
authors: Tan
authors: Cheng-Lin
authors: CL
authors: Tian
authors: Xu-Sheng
authors: XS
authors: Huang
authors: Lin
authors: L
authors: Ma
authors: Sheng-Yuan
authors: SY
authors: Yu
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013223:Statistics as Topic