title: Nocturia is an independent predictive factor of prevalent hypertension in obstructive sleep apnea patients.
abstract: OBJECTIVE
  The aim of this study was to determine whether nocturia is an independent predictor for prevalent hypertension in obstructive sleep apnea (OSA).
  
  
  METHODS
  We analyzed data from a national prospective clinical cohort of OSA patients participating in the French national prospective registry. Anthropometric data, comorbidities, OSA severity, and number of voids/night were included in multivariate analyses to determine the independent variables associated with prevalent hypertension.
  
  
  RESULTS
  A total of 22,674 OSA patients were included, of which 11,332 were hypertensive. The prevalence of hypertension among OSA patients was about 1.3 times higher in patients suffering from nocturia at 61.45% versus 46.52% in hypertensive and non-hypertensive OSA patients (p <0.001). There was a significant positive relationship between hypertension and the severity of nocturia beyond two voids/night: two voids/night versus none: odds ratio (OR) = 1.270 (95% confidence interval (CI) = 1.175; 1.372), three voids/night versus none: OR = 1.422 (95% CI = 1.293; 1.565), and four voids/night versus none: OR = 1.575 (95% CI = 1.394; 1.781). The strength of the association was enhanced in patients over 64 years of age.
  
  
  CONCLUSIONS
  Nocturia is a strong independent predictor of prevalent hypertension in OSA. This association exhibited a "dose-response" relationship beyond two voids/night. The resolution of nocturia after continuous positive airway pressure (CPAP) treatment might be an important outcome to consider for the response of hypertension to CPAP.
authors: HP2 Laboratory, INSERM U 1042, University Grenoble Alpes, Grenoble, France; Service de Pneumologie, CHU Grenoble, Grenoble, France. Electronic address: mdestors@chu-grenoble.fr.
authors: Marie
authors: M
authors: Destors
authors: HP2 Laboratory, INSERM U 1042, University Grenoble Alpes, Grenoble, France; Pôle Locomotion, Rééducation et Physiologie, CHU Grenoble, Grenoble, France.
authors: Renaud
authors: R
authors: Tamisier
authors: Unité Sommeil et Vigilance, Polyclinique Bordeaux Caudéran, Bordeaux, France.
authors: Marc
authors: M
authors: Sapene
authors: Pneumologie, Cabinet Médical, Valence, France.
authors: Yves
authors: Y
authors: Grillet
authors: Unité d'Hypertension artérielle, Clinique de cardiologie, CHU de Grenoble, Grenoble, France.
authors: Jean-Philippe
authors: JP
authors: Baguet
authors: Pneumologie, Cabinet Médical, St-Omer, France.
authors: Philippe
authors: P
authors: Richard
authors: Pneumologie, Cabinet Médical, Grenoble, France.
authors: Janie
authors: J
authors: Girey-Rannaud
authors: HP2 Laboratory, INSERM U 1042, University Grenoble Alpes, Grenoble, France; Pôle Locomotion, Rééducation et Physiologie, CHU Grenoble, Grenoble, France.
authors: Sonia
authors: S
authors: Dias-Domingos
authors: Unité des pathologies du sommeil, Centre hospitalier de Compiègne, Compiègne, France.
authors: Francis
authors: F
authors: Martin
authors: Pneumologie, Cabinet Médical Saint Michel, Valenciennes, France.
authors: Bruno
authors: B
authors: Stach
authors: Service de Pneumologie, Centre Hospitalier Intercommunal Créteil, Créteil, France.
authors: Bruno
authors: B
authors: Housset
authors: HP2 Laboratory, INSERM U 1042, University Grenoble Alpes, Grenoble, France; Pôle Locomotion, Rééducation et Physiologie, CHU Grenoble, Grenoble, France.
authors: Patrick
authors: P
authors: Levy
authors: HP2 Laboratory, INSERM U 1042, University Grenoble Alpes, Grenoble, France; Pôle Locomotion, Rééducation et Physiologie, CHU Grenoble, Grenoble, France.
authors: Jean-Louis
authors: JL
authors: Pepin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications*; D055815:Young Adult
keywords: Cardiovascular risk; Hypertension; Nocturia; Obstructive sleep apnea