title: Randomized, Multicenter Clinical Study of Tratinterol Hydrochloride Tablets for the Treatment of Bronchial Asthma.
abstract: OBJECTIVE
  The aim of this study was to determine the efficacy and safety profile of tratinterol hydrochloride tablets in the treatment of bronchial asthma.
  
  
  METHODS
  This multicenter, randomized, double-blind clinical research study was completed at 6 centers in the People's Republic of China from March 2009 to June 2010, and a randomized trial of procaterol hydrochloride tablets produced by Otsuka Pharmaceutical Co Ltd was conducted. The study was approved by the Medical Ethics Committee of the First Hospital of China Medical University. The clinical trial registration number is 2007L04263.
  
  
  RESULTS
  A total of 223 patients were selected for this study, with 112 patients in the treatment group and 111 in the control group. The lung function of the 2 groups after treatment significantly increased in all (P < 0.05); however, there was no significant difference in the changes between the 2 groups (P > 0.05). The occurrence of related adverse events at varying degrees in the control group was higher than in the treatment group.
  
  
  CONCLUSIONS
  It is safe and effective to use tratinterol hydrochloride tablets to treat bronchial asthma.
authors: The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
authors: Lingfei
authors: L
authors: Kong
authors: The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
authors: Jiaming
authors: J
authors: Liu
authors: Daqing General Hospital Group, Oilfield General Hospital, Daqing, Heilongjiang Province, China.
authors: Guozhong
authors: G
authors: Gu
authors: The First Affiliated Hospital of HarBin Medical University, HarBin, Heilongjiang Province, China.
authors: Jianmin
authors: J
authors: Huo
authors: The Second Hospital of Jilin University, Changchun, Jilin, Province, China.
authors: Zhongsen
authors: Z
authors: Ma
authors: The Second Affiliated Hospital of Harbin Medical University, HarBin, Heilongjiang, Province, China.
authors: Yuxia
authors: Y
authors: Shao
authors: The Third Xiangya Hospital, Changsha, Hunan Province, China.
authors: Shenghua
authors: S
authors: Sun
authors: The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
authors: Yuan
authors: Y
authors: Yuan
authors: The Department of Health Statistics of Peking University, Beijing, China.
authors: Sainan
authors: S
authors: Zhu
authors: The Department of Health Statistics of Peking University, Beijing, China.
authors: Chen
authors: C
authors: Yao
authors: Jinzhou Jiutai Pharmaceutical Co Ltd, Jinzhou, Liaoning Province, China.
authors: Guijie
authors: G
authors: Du
authors: Shenyang Pharmaceutical University, Shenyang, Liaoning Province, China.
authors: Maosheng
authors: M
authors: Cheng
authors: The First Hospital of China Medical University, Shenyang, Liaoning Province, China. Electronic address: kangjian58@163.com.
authors: Jian
authors: J
authors: Kang
mesh_terms: D000328:Adult; D000814:Aniline Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002681:China; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010626:Phenylethyl Alcohol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017265:Procaterol / Q000627:therapeutic use; D012129:Respiratory Function Tests; D013607:Tablets
chemical_list: D000814:Aniline Compounds; D001993:Bronchodilator Agents; D013607:Tablets; C000606156:tratinterol; D010626:Phenylethyl Alcohol; D017265:Procaterol
keywords: asthma; procaterol hydrochloride; randomized multicenter clinical study; tratinterol hydrochloride; β(2)-adrenergic receptor agonist