title: In vivo, percutaneous, needle based, optical coherence tomography of renal masses.
abstract: Optical coherence tomography (OCT) is the optical equivalent of ultrasound imaging, based on the backscattering of near infrared light. OCT provides real time images with a 15 µm axial resolution at an effective tissue penetration of 2-3 mm. Within the OCT images the loss of signal intensity per millimeter of tissue penetration, the attenuation coefficient, is calculated. The attenuation coefficient is a tissue specific property, providing a quantitative parameter for tissue differentiation. Until now, renal mass treatment decisions have been made primarily on the basis of MRI and CT imaging characteristics, age and comorbidity. However these parameters and diagnostic methods lack the finesse to truly detect the malignant potential of a renal mass. A successful core biopsy or fine needle aspiration provides objective tumor differentiation with both sensitivity and specificity in the range of 95-100%. However, a non-diagnostic rate of 10-20% overall, and even up to 30% in SRMs, is to be expected, delaying the diagnostic process due to the frequent necessity for additional biopsy procedures. We aim to develop OCT into an optical biopsy, providing real-time imaging combined with on-the-spot tumor differentiation. This publication provides a detailed step-by-step approach for percutaneous, needle based, OCT of renal masses.
authors: Department of Urology, Academic Medical Center; p.g.wagstaff@amc.nl.
authors: Peter G
authors: PG
authors: Wagstaff
authors: Department of Biomedical Engineering and Physics, Academic Medical Center.
authors: Abel
authors: A
authors: Swaan
authors: Department of Urology, Academic Medical Center.
authors: Alexandre
authors: A
authors: Ingels
authors: Department of Urology, Academic Medical Center.
authors: Patricia J
authors: PJ
authors: Zondervan
authors: Department of Radiology, Academic Medical Center.
authors: Otto M
authors: OM
authors: van Delden
authors: Department of Biomedical Engineering and Physics, Academic Medical Center.
authors: Dirk J
authors: DJ
authors: Faber
authors: Department of Biomedical Engineering and Physics, Academic Medical Center.
authors: Ton G
authors: TG
authors: van Leeuwen
authors: Department of Urology, Academic Medical Center.
authors: Jean J
authors: JJ
authors: de la Rosette
authors: Department of Urology, Academic Medical Center; Department of Biomedical Engineering and Physics, Academic Medical Center.
authors: Daniel M
authors: DM
authors: de Bruin
authors: Department of Urology, Academic Medical Center.
authors: M Pilar
authors: MP
authors: Laguna Pes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002454:Cell Differentiation / Q000502:physiology; D003199:Computer Systems; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009339:Needles; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*