title: Global burden of invasive nontyphoidal Salmonella disease, 2010(1).
abstract: Nontyphoidal Salmonella is a major cause of bloodstream infections worldwide, and HIV-infected persons and malaria-infected children are at increased risk for the disease. We conducted a systematic literature review to obtain age group-specific, population-based invasive nontyphoidal Salmonella (iNTS) incidence data. Data were categorized by HIV and malaria prevalence and then extrapolated by using 2010 population data. The case-fatality ratio (CFR) was determined by expert opinion consensus. We estimated that 3.4 (range 2.1-6.5) million cases of iNTS disease occur annually (overall incidence 49 cases [range 30-94] per 100,000 population). Africa, where infants, young children, and young adults are most affected, has the highest incidence (227 cases [range 152-341] per 100,000 population) and number of cases (1.9 [range 1.3-2.9] million cases). An iNTS CFR of 20% yielded 681,316 (range 415,164-1,301,520) deaths annually. iNTS disease is a major cause of illness and death globally, particularly in Africa. Improved understanding of the epidemiology of iNTS is needed.
authors: Trong T
authors: TT
authors: Ao
authors: Nicholas A
authors: NA
authors: Feasey
authors: Melita A
authors: MA
authors: Gordon
authors: Karen H
authors: KH
authors: Keddy
authors: Frederick J
authors: FJ
authors: Angulo
authors: John A
authors: JA
authors: Crump
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D014943:Global Health; D015658:HIV Infections / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008288:Malaria / Q000453:epidemiology; D008875:Middle Aged; D009026:Mortality; D012475:Salmonella / Q000145:classification*; D012480:Salmonella Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality; D016036:Seroepidemiologic Studies; D055815:Young Adult
keywords: Salmonella; bacteremia; bacteria; global burden; incidence; invasive disease; nontyphoidal Salmonella disease