title: Enhanced dendritic integration by ih reduction in the anterior cingulate cortex increases nociception.
abstract: In this issue of Neuron, Santello and Nevian (2015) report HCN channel plasticity and increased temporal summation in layer 5 ACC neurons following nerve injury. They are able to restore HCN channel function and reduce behavioral hypersensitivity with selective serotonin receptor targeting.
authors: Department of Anesthesiology, Perioperative and Pain Medicine, Department of Molecular and Cellular Physiology, Department of Neurosurgery, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA; Biology Graduate Program, Stanford University, Stanford, CA 94305, USA.
authors: Jasmine R
authors: JR
authors: Dickinson
authors: Department of Anesthesiology, Perioperative and Pain Medicine, Department of Molecular and Cellular Physiology, Department of Neurosurgery, Stanford Neurosciences Institute, Stanford University, Palo Alto, CA 94304, USA. Electronic address: gs25@stanford.edu.
authors: Grégory
authors: G
authors: Scherrer
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology*; D003712:Dendrites / Q000473:pathology*; D008297:Male; D009437:Neuralgia / Q000473:pathology* / Q000628:therapy*; D009474:Neurons / Q000473:pathology*; D012701:Serotonin / Q000378:metabolism*
chemical_list: D012701:Serotonin