title: [MAM-E17 schizophrenia rat model].
abstract: Schizophrenia is a serious neuropsychiatric disorder. Several brain structures, neurotransmitter systems, genetic and environmental risk factors are suspected in the background. Because of its complexity the mechanism of the disorder is not known exactly, so the treatment of patients is unsolved. In the research of schizophrenia application of the rodent models is widespread. In this study one of these models based on the effect of methylazoxymethanol- acetate (MAM) is described, which is a neurodevelopmental, validated rat model. This antimitotic agent is able to evoke a number of schizophrenic symptomes temporarily disrupting the prenatal neurogenesis. The model reproduces numerous histological and neurophysiological changes of the human disorder, moreover it also represents several behavioral and cognitive phenomena resembling those in schizophrenia. A salient advantage of the model is the demonstration of the diachronic feature of the disorder, that is, postpubertal appearance of the positive symptoms. This model provides widespread opportunities for manipulations of the symptoms, so that using it in the future investigations can lead to a better understanding of this disorder.
authors: PTE AOK Elettani Intezet, Pecs, Hungary, E-mail: laszlo.lenard@aok.pte.hu.
authors: Veronika
authors: V
authors: Kállai
authors: Attila
authors: A
authors: Tóth
authors: Rita
authors: R
authors: Gálosi
authors: Imre
authors: I
authors: Szabó
authors: Zoltán
authors: Z
authors: Petykó
authors: Zoltán
authors: Z
authors: Karádi
authors: János
authors: J
authors: Kállai
authors: László
authors: L
authors: Lénárd
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D003071:Cognition; D004195:Disease Models, Animal; D005625:Frontal Lobe / Q000378:metabolism / Q000503:physiopathology; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D008032:Limbic System / Q000378:metabolism / Q000503:physiopathology; D008124:Locomotion; D008746:Methylazoxymethanol Acetate / Q000378:metabolism / Q000633:toxicity*; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology; D009498:Neurotoxins / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D012559:Schizophrenia / Q000139:chemically induced* / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012919:Social Behavior
chemical_list: D009498:Neurotoxins; D008746:Methylazoxymethanol Acetate