title: Lack of genetic association between TREM2 and Alzheimer's disease in East Asian population: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Large-scale genome-wide association studies have identified TREM2 variants to be significantly associated with Alzheimer's disease (AD) in caucasian population. The goal of this systematic study and meta-analysis was to assess the association between Triggering receptor expressed on myeloid cells 2 (TREM2) variants and AD in East Asian population.
  
  
  METHODS
  In this study, literatures were searched in PubMed, MEDLINE, EMBASE, and the Cochrane library to screen citations from January 1990 to June 2014. Data analysis was done by using the Stata 12 software.
  
  
  RESULTS
  Twelve studies were considered for analysis. A total of 13 535 patients with AD and 22 976 healthy controls were studied. The results showed that rs75932628 variant was significantly associated with AD in caucasian population (P < .001, odds ratio ¼ 3.17, 95% confidence interval 2.45-4.09). However, the association was not found in East Asian population.
  
  
  CONCLUSIONS
  In our study, we found that TREM2 variant is likely not associated with AD in East Asian population.
authors: Department of General Intensive Care Unit, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors: Man
authors: M
authors: Huang
authors: Dejun
authors: D
authors: Wang
authors: Zhijun
authors: Z
authors: Xu
authors: Yongshan
authors: Y
authors: Xu
authors: Xiaoping
authors: X
authors: Xu
authors: Yuefeng
authors: Y
authors: Ma
authors: Zheng
authors: Z
authors: Xia
mesh_terms: D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D005202:Asia, Eastern / Q000208:ethnology; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; C498715:TREM2 protein, human