title: Therapeutic plasma exchange as a steroid-sparing therapy in a patient with limbic encephalitis due to antibodies to voltage-gated potassium channels.
abstract: Autoantibodies to the voltage-gated potassium channel (VGKC) complex cause a spectrum of non-paraneoplastic neurologic syndromes including limbic encephalitis (LE). We report a case of a man with LE who underwent a course of therapeutic plasma exchange (TPE) in addition to other immunomodulatory therapies and experienced sustained clinical resolution of his symptoms. This report adds to the existing literature supporting TPE in cases of LE due to VGKC complex autoantibodies.
authors: Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
authors: Isabella W
authors: IW
authors: Martin
authors: Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
authors: Christi-Lynn B
authors: CL
authors: Martin
authors: Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
authors: Nancy M
authors: NM
authors: Dunbar
authors: Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
authors: Stephen L
authors: SL
authors: Lee
authors: Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
authors: Zbigniew M
authors: ZM
authors: Szczepiorkowski
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood* / Q000302:isolation & purification; D006801:Humans; D020363:Limbic Encephalitis / Q000209:etiology / Q000276:immunology* / Q000628:therapy*; D008297:Male; D010951:Plasma Exchange; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D013256:Steroids / Q000009:adverse effects
chemical_list: D001323:Autoantibodies; D024642:Potassium Channels, Voltage-Gated; D013256:Steroids
keywords: LGI1antibodies; TPE; VGKC antibodies