title: Solanioic Acid, an Antibacterial Degraded Steroid Produced in Culture by the Fungus Rhizoctonia solani Isolated from Tubers of the Medicinal Plant Cyperus rotundus.
abstract: Solanioic acid (1), a degraded and rearranged steroid that exhibits in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), has been isolated from laboratory cultures of the fungus Rhizoctonia solani obtained from tubers of the plant Cyperus rotundus collected in Sri Lanka. The structure of solanioic acid (1) was elucidated by detailed analysis of NMR data, a single crystal X-ray diffraction analysis of a reduction product 2, and Mosher ester analysis on a derivative of the natural product. Solanioic acid (1) has an unprecedented carbon skeleton.
authors: †Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka.|‡Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, 2036 Main Mall, Vancouver, B.C., Canada V6T 1Z1.|∥Department of Science and Technology, Uva Wellassa University, Badulla, Sri Lanka.
authors: Pamoda B
authors: PB
authors: Ratnaweera
authors: ‡Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, 2036 Main Mall, Vancouver, B.C., Canada V6T 1Z1.
authors: David E
authors: DE
authors: Williams
authors: §Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, B.C., Canada V6T 1Z1.
authors: Brian O
authors: BO
authors: Patrick
authors: †Department of Chemistry, University of Colombo, Colombo 03, Sri Lanka.
authors: E Dilip
authors: ED
authors: de Silva
authors: ‡Departments of Chemistry and Earth, Ocean and Atmospheric Sciences, University of British Columbia, 2036 Main Mall, Vancouver, B.C., Canada V6T 1Z1.
authors: Raymond J
authors: RJ
authors: Andersen
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D029786:Cyperus / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008968:Molecular Conformation; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012232:Rhizoctonia / Q000737:chemistry*; D013188:Sri Lanka; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013256:Steroids; C000601155:solanioic acid