title: Influence of selenium on radiogenic collagen destruction and the degree of collagen tissue maturation in stage III oral squamous cell carcinoma patients undergoing therapeutic irradiation.
abstract: BACKGROUND
  We set out to assess whether selenium, an antioxidant mineral could influence radiogenic collagen maturation.
  
  
  METHODS
  The study comprise of normal (Group I), untreated oral carcinoma cases (Group II) (n = 20), cases who underwent radiotherapy (Group IIa) n = 10 and cases supplemented with selenium along with radiotherapy (Group IIb) n = 10.
  
  
  RESULTS
  Spectrophotometric estimation and luminescence spectral assignment of collagen showed improved collagen maturation status. Measurement of the mature collagen cross-links hydroxylysylpyridinoline and lysylpyridinoline by high-performance liquid chromatography on irradiated tissues showed a considerable decrease in the selenium Group IIb (P < 0.05) indicating a decrease in collagen fragments. Electron microscopic studies showed significant morphological alteration in the selenium group. The micro nucleus frequency, decreased in radiation group (P < 0.05) compared with untreated (P < 0.05). While much more decrease observed in the selenium group (P < 0.05).
  
  
  CONCLUSIONS
  The results represent the effect of selenium treatment with a bearing on carcinogenic process to curtail it, thus enhancing the maturity of collagen.
authors: Department of Radiological Science, College of Medical Science, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-Eup, Gyeongsan-Si, Gyeongbuk 712-702, Korea.
authors: Sonaa
authors: S
authors: Elango
authors: Usha
authors: U
authors: Subbiah
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy* / Q000648:ultrastructure; D003094:Collagen / Q000378:metabolism*; D019587:Dietary Supplements; D005260:Female; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects / Q000528:radiation effects; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy* / Q000648:ultrastructure; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009696:Nucleic Acids / Q000378:metabolism; D012643:Selenium / Q000008:administration & dosage*; D016896:Treatment Outcome; D014364:Tryptophan / Q000378:metabolism; D047368:Tumor Burden
chemical_list: D000975:Antioxidants; D009696:Nucleic Acids; D005182:Flavin-Adenine Dinucleotide; D014364:Tryptophan; D003094:Collagen; D012643:Selenium; D006909:Hydroxyproline