title: Antimalarial activity of tulathromycin in a murine model of malaria.
abstract: There is an urgent need for new antimalarial agents and strategies to treat and control malaria. This study shows an antiplasmodium effect of tulathromycin in mice infected with Plasmodium yoelii. The administration of tulathromycin around the time of infection prevented the progression of disease in 100% of the animals. In addition, highly parasitized mice treated with tulathromycin showed a decreased parasite burden and cleared the parasite faster than did untreated infected mice.
authors: Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.
authors: Nicolas
authors: N
authors: Villarino
authors: Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA.
authors: Joshua E
authors: JE
authors: Denny
authors: Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA Department of Microbiology and Immunology, University of Louisville, Louisville, Kentucky, USA nathan.schmidt@louisville.edu.
authors: Nathan W
authors: NW
authors: Schmidt
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D004187:Disaccharides / Q000627:therapeutic use*; D005260:Female; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D010967:Plasmodium yoelii / Q000187:drug effects* / Q000472:pathogenicity*; D018942:Macrolides
chemical_list: D000962:Antimalarials; D004187:Disaccharides; D006571:Heterocyclic Compounds; C485204:tulathromycin; D018942:Macrolides