title: The future of transcatheter mitral valve interventions: competitive or complementary role of repair vs. replacement?
abstract: Transcatheter mitral interventions has been developed to address an unmet clinical need and may be an alternative therapeutic option to surgery with the intent to provide symptomatic and prognostic benefit. Beyond MitraClip therapy, alternative repair technologies are being developed to expand the transcatheter intervention armamentarium. Recently, the feasibility of transcatheter mitral valve implantation in native non-calcified valves has been reported in very high-risk patients. Acknowledging the lack of scientific evidence to date, it is difficult to predict what the ultimate future role of transcatheter mitral valve interventions will be. The purpose of the present report is to review the current state-of-the-art of mitral valve intervention, and to identify the potential future scenarios, which might benefit most from the transcatheter repair and replacement devices under development.
authors: University Hospital of Zurich, Rämistrasse 100, 8089-CH, Zurich, Switzerland francesco.maisano@usz.ch.
authors: Francesco
authors: F
authors: Maisano
authors: San Raffaele University Hospital, Milan, Italy.
authors: Ottavio
authors: O
authors: Alfieri
authors: Tel-Aviv Medical Center, Tel-Aviv, Israel.
authors: Shmuel
authors: S
authors: Banai
authors: Foundation for Cardiovascular Medicine, San Diego, USA.
authors: Maurice
authors: M
authors: Buchbinder
authors: San Raffaele University Hospital, Milan, Italy.
authors: Antonio
authors: A
authors: Colombo
authors: Deutsches Herzzentrum Berlin, Berlin, Germany.
authors: Volkmar
authors: V
authors: Falk
authors: Evanston Hospital, Evanston, USA.
authors: Ted
authors: T
authors: Feldman
authors: Rigshospitalet, Copenhagen, Denmark.
authors: Olaf
authors: O
authors: Franzen
authors: Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
authors: Howard
authors: H
authors: Herrmann
authors: Cedars Sinai Medical Center, Los Angeles, USA.
authors: Saibal
authors: S
authors: Kar
authors: Asklepios Klinik St. Georg, Hamburg, Germany.
authors: Karl-Heinz
authors: KH
authors: Kuck
authors: University of Kiel, Kiel, Germany.
authors: Georg
authors: G
authors: Lutter
authors: The Heart Hospital, Plano, USA.
authors: Michael
authors: M
authors: Mack
authors: University of Bonn, Bonn, Germany.
authors: Georg
authors: G
authors: Nickenig
authors: McGill University Health Centre, Montreal, Canada.
authors: Nicolo
authors: N
authors: Piazza
authors: University of Washington Medical Center, Washington, USA.
authors: Mark
authors: M
authors: Reisman
authors: Lenox Hill Heart and Vascular Institute of New York, New York, USA.
authors: Carlos E
authors: CE
authors: Ruiz
authors: Hamburg University Cardiovascular Center, Hamburg, Germany.
authors: Joachim
authors: J
authors: Schofer
authors: Rigshospitalet, Copenhagen, Denmark.
authors: Lars
authors: L
authors: Søndergaard
authors: Columbia University Medical Center, New York Presbyterian Hospital, New York, USA.
authors: Gregg W
authors: GW
authors: Stone
authors: University Hospital of Zurich, Rämistrasse 100, 8089-CH, Zurich, Switzerland.
authors: Maurizio
authors: M
authors: Taramasso
authors: Guy's & St Thomas' Hospitals NHS Foundation Trust, London, UK.
authors: Martyn
authors: M
authors: Thomas
authors: Bichat Hospital, Paris, France.
authors: Alec
authors: A
authors: Vahanian
authors: St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors: John
authors: J
authors: Webb
authors: Bern University Hospital, Bern, Switzerland.
authors: Stephan
authors: S
authors: Windecker
authors: Columbia University Medical Center, New York Presbyterian Hospital, New York, USA.
authors: Martin B
authors: MB
authors: Leon
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D001705:Bioprosthesis; D006328:Cardiac Catheterization / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D004452:Echocardiography; D004867:Equipment Design; D005471:Fluoroscopy; D005544:Forecasting; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D006801:Humans; D008943:Mitral Valve / Q000502:physiology; D058386:Mitral Valve Annuloplasty / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D008944:Mitral Valve Insufficiency / Q000503:physiopathology / Q000601:surgery*; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D000925:Anticoagulants
keywords: Transcatheter mitral implantation; Transcatheter mitral intervention; Transcatheter mitral repair