title: Advantages of single-puncture transperineal saturation biopsy of prostate: analysis of outcomes in 125 patients using our scheme.
abstract: OBJECTIVE
  Stereotactic biopsy has improved prostate cancer detection. Although the new approach is superior, standard procedure is still useful in a cohort of patients in whom MRI is not available. The standard saturation biopsy technique is still debatable. We describe our technique and analyze its outcomes.
  
  
  METHODS
  One hundred twenty-five patients underwent saturation biopsy through a single transperineal access. Mean age was 64.73 year, mean PSA was 9.49 ng/ml, mean PSA density was 0.184, and mean prostate volume was 57.95 g. All patients underwent at least one previous prostatic biopsy: 24.8% of cases had diagnosis of atypical small acinar proliferation, 39.2% of cases had multifocal high-grade prostatic intraepithelial neoplasia, and 36% of cases had inflammation or benign prostatic hyperplasia.
  
  
  RESULTS
  The detection rate was 38.4%. Prostate cancer occurred in 61.3% of patients with previous ASAP (p < 0.007). Cancer detection rate decreased with increasing number of previous biopsy and with increasing prostate volume (p < 0.001) and increased with increasing PSA density (p = 0.03). No major complications were reported.
  
  
  CONCLUSIONS
  The traditional saturation biopsy may be useful when targeted biopsy cannot be used. Our technique is accurate for cancer detection. It can offer some advantages in comparison with other approaches.
authors: Policlinico di Modena, Department of Urology, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy, eugeniomartorana@libero.it.
authors: Eugenio
authors: E
authors: Martorana
authors: Salvatore
authors: S
authors: Micali
authors: Ahmed
authors: A
authors: Ghaith
authors: Luca
authors: L
authors: Reggiani Bonetti
authors: Maria Chiara
authors: MC
authors: Sighinolfi
authors: Riccardo
authors: R
authors: Galli
authors: Maurizio
authors: M
authors: Paterlini
authors: Giampaolo
authors: G
authors: Bianchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009929:Organ Size; D010502:Perineum; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen; D011470:Prostatic Hyperplasia / Q000473:pathology*; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology* / Q000628:therapy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000628:therapy; D011677:Punctures; D012086:Reoperation; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen