title: CHRNA3 rs6495308 genotype as an effect modifier of the association between daily cigarette consumption and hypertension in Chinese male smokers.
abstract: Cigarette smoking is an important risk factor for hypertension. However, the effects on hypertension of the interaction between smoking and the genotype of the nicotinic acetylcholine receptor gene are unclear. The purpose of this study is to determine whether the CHRNA3 rs6495308 genotype affects the association between daily cigarette consumption and hypertension. We recruited 947 male smokers in southern China and used a questionnaire administered in face to face interviews to obtain information on their socio-demographic characteristics and smoking behavior. Blood samples were collected to test for CHRNA3 rs6495308 genotype variations. Three blood-pressure measurements were taken for each participant, and the average values recorded. We found that, compared with light smoking (<15 cigarettes per day), heavy smoking (≥15 cigarettes per day) yielded a greater risk of hypertension. We also observed that the interaction between daily cigarette consumption and the CHRNA3 rs6495308 genotype may affect hypertension. Heavy smokers with the homozygous mutant CHRNA3 rs6495308 genotype exhibited a significantly greater risk of hypertension than light smokers with wild-type CHRNA3 rs6495308 genotypes. The positive interaction between heavy smoking and the homozygous mutant CHRNA3 rs6495308 genotype was found to affect the likelihood of hypertension in Chinese male smokers.
authors: Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China. xiaoyingwu2014@hotmail.com.
authors: Xiao-Ying
authors: XY
authors: Wu
authors: Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou, Guangdong 510000, China. sandyzhou168@sina.com.
authors: Shan-Yu
authors: SY
authors: Zhou
authors: Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China. niuxshijia@hotmail.com.
authors: Zhong-Zheng
authors: ZZ
authors: Niu
authors: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong 510000, China. gztt_2002@163.com.
authors: Tao
authors: T
authors: Liu
authors: Division of Behavioral Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, NY 14228, USA. xieechuanbo@126.com.
authors: Chuan-Bo
authors: CB
authors: Xie
authors: Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China. chenwq@mail.sysu.edu.cn.
authors: Wei-Qing
authors: WQ
authors: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D003430:Cross-Sectional Studies; D015987:Effect Modifier, Epidemiologic; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006720:Homozygote; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011978:Receptors, Nicotinic / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000235:genetics
chemical_list: D005819:Genetic Markers; D011978:Receptors, Nicotinic