title: The diagnostic value of 18F-FDG PET/CT in association with serum tumor marker assays in breast cancer recurrence and metastasis.
abstract: BACKGROUND
  After initial treatment of breast cancer (BC), monitoring locoregional recurrence and distant metastases is a great clinical challenge.
  
  
  OBJECTIVE
  To evaluate the efficacy of PET/CT in association with serum tumor makers in BC follow-up.
  
  
  METHODS
  Twenty-six women with a history of modified radical mastectomy were evaluated by 18F-FDG PET/CT. The results of PET/CT were compared with those of conventional imaging techniques (CITs) (including mammography, chest radiography, CT, MRI, ultrasound, and bone scintigraphy). Serum tumor markers of CEA, CA 125, and CA 15-3 in the BC patients were also analyzed in association with the results of PET/CT.
  
  
  RESULTS
  Compared with CITs, PET/CT was more sensitive to detect the malignant foci and had better patient-based sensitivity and specificity. The mean CA 15-3 serum level was significantly higher in the confirmed positive patients of PET/CT results than in the confirmed negative ones, while there were no significant differences in the serum levels of CEA and CA 125 of both groups.
  
  
  CONCLUSIONS
  PET/CT is a highly efficient tool for BC follow-up compared with CITs. The high serum levels of CA 15-3 in confirmed positive PET/CT patients indicated the clinical value of CA 15-3 in BC follow-up.
authors: Department of Oncology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
authors: Ying
authors: Y
authors: Dong
authors: Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China ; Zhejiang University Medical PET Center, Hangzhou 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China.
authors: Haifeng
authors: H
authors: Hou
authors: Beijing 307 Hospital, Beijing 100071, China.
authors: Chunyan
authors: C
authors: Wang
authors: Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China ; Zhejiang University Medical PET Center, Hangzhou 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China.
authors: Jing
authors: 0000-0003-2201-2523
authors: J
authors: Li
authors: Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China ; Zhejiang University Medical PET Center, Hangzhou 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China.
authors: Qiong
authors: Q
authors: Yao
authors: Department of Zoology, Faculty of Science, Kafr El Sheikh University, Kafr El Sheikh 33516, Egypt.
authors: Said
authors: 0000-0002-2920-6702
authors: S
authors: Amer
authors: Department of Nuclear Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China ; Zhejiang University Medical PET Center, Hangzhou 310009, China ; Institute of Nuclear Medicine and Molecular Imaging, Zhejiang University, Hangzhou 310009, China ; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou 310009, China.
authors: Mei
authors: M
authors: Tian
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D018394:CA-125 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D049268:Positron-Emission Tomography; D011859:Radiography
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D019788:Fluorodeoxyglucose F18