title: Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease.
abstract: Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed to study the relationship between YKL-40 and brain structure and its interactions with core Alzheimer's disease (AD) biomarkers. We measured cortical thickness (CTh) and cerebrospinal fluid biomarkers (amyloid-β 1-42 [Aβ42], total tau, p-tau, and YKL-40) of 80 cognitively normal controls and 27 patients with amnestic mild cognitive impairment. Subjects were classified as Aβ42+ (<550 pg/mL) or Aβ42- (>550 pg/mL). CTh difference maps were derived from the interaction and correlation analyses in the whole sample and within clinical groups. There was a strong correlation between YKL-40 and markers of neurodegeneration (total tau and p-tau). In the whole sample, we found a negative correlation between YKL-40 and CTh in AD vulnerable areas in Aβ42+ subjects but not in Aβ42 participants. Our results suggest that YKL-40 could track the inflammatory processes associated to tau-related neurodegeneration in the presence of the AD pathophysiological process.
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: Daniel
authors: D
authors: Alcolea
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: Eduard
authors: E
authors: Vilaplana
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: Jordi
authors: J
authors: Pegueroles
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: Victor
authors: V
authors: Montal
authors: Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Department of Neurology, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain.
authors: Pascual
authors: P
authors: Sánchez-Juan
authors: Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Department of Neurology, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain.
authors: Andrea
authors: A
authors: González-Suárez
authors: Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Department of Neurology, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain.
authors: Ana
authors: A
authors: Pozueta
authors: Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Department of Neurology, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain.
authors: Eloy
authors: E
authors: Rodríguez-Rodríguez
authors: Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors: David
authors: D
authors: Bartrés-Faz
authors: Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
authors: Dídac
authors: D
authors: Vidal-Piñeiro
authors: Department of Radiology, Hospital del Mar, Barcelona, Spain.
authors: Sofía
authors: S
authors: González-Ortiz
authors: Department of Radiology, Hospital del Mar, Barcelona, Spain.
authors: Santiago
authors: S
authors: Medrano
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: María
authors: M
authors: Carmona-Iragui
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: MaBelén
authors: M
authors: Sánchez-Saudinós
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: Isabel
authors: I
authors: Sala
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: Sofía
authors: S
authors: Anton-Aguirre
authors: Faculty of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
authors: Frederic
authors: F
authors: Sampedro
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: Estrella
authors: E
authors: Morenas-Rodríguez
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: Jordi
authors: J
authors: Clarimón
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: Rafael
authors: R
authors: Blesa
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
authors: Alberto
authors: A
authors: Lleó
authors: Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address: jfortea@santpau.cat.
authors: Juan
authors: J
authors: Fortea
mesh_terms: D054392:Adipokines / Q000134:cerebrospinal fluid*; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology; D001284:Atrophy; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002540:Cerebral Cortex / Q000473:pathology*; D000071451:Chitinase-3-Like Protein 1; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation; D037102:Lectins / Q000134:cerebrospinal fluid*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016875:tau Proteins / Q000134:cerebrospinal fluid
chemical_list: D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins; D016875:tau Proteins
keywords: CSF biomarkers; Cortical thickness; Neuroinflammation; Preclinical Alzheimer's disease; Structural MRI; YKL-40