title: Doxycycline as a modulator of inflammation in chronic wounds.
abstract: ﻿﻿﻿﻿﻿﻿ Doxycycline is a semisynthetic, chemically modified tetracycline compound that is rapidly absorbed and exerts biological effects independent of its antimicrobial activity. One such effect includes the inhibition of matrix metalloproteinases. Doxycycline has a long history as a collagenase inhibitor. This article will describe its mode of action and review its effectiveness in significantly reducing inflammation and elevated levels of proinflammatory cytokines within chronic wounds. ﻿﻿﻿.
authors: Healogics, Inc, Jacksonville, FL; email: jrwilcox1120@yahoo.com.
authors: James R
authors: JR
authors: Wilcox
authors: Healogics, Inc, Jacksonville, FL.
authors: D Scott
authors: DS
authors: Covington
authors: Healogics, Inc, Jacksonville, FL.
authors: Nancy
authors: N
authors: Paez