title: [Early clinical outcomes of percutaneous balloon aortic valvuloplasty in treating high-risk patients with severe aortic stenosis].
abstract: OBJECTIVE
  To explore the procedural feasibility and early clinical outcomes of percutaneous balloon aortic valvuloplasty (PBAV) in patients with severe aortic stenosis, who were considered transiently unsuitable for surgical aortic valve replacement (sAVR) and transcatheter aortic valve replacement (TAVR).
  
  
  METHODS
  Between March 2011 and January 2014, datas of 20 patients underwent PBAV in Fuwai Hospital were retrospectively analyzed. Mean patients age was (72 ± 8) years.Initial procedural and clinical outcomes were evaluated.
  
  
  RESULTS
  PBAV was successfully performed in all cases. Post-procedure, aortic valve area increased from (0.55 ± 0.09) m(2) to (0.77 ± 0.15) m(2)(P < 0.001), left ventricle ejection fraction from (31.7 ± 9.0) % to (39.0 ± 11.0) % (P = 0.018), mean transaortic valve gradient decreased from (49.5 ± 15.0) mmHg (1 mmHg = 0.133 kPa) to (31.7 ± 12.0) mmHg (P < 0.001), and pulmonary artery systolic pressure decreased from (55.1 ± 18.0) mmHg to (38.7 ± 11.0) mmHg (P = 0.025) . There was no significant change in the aortic regurgitation grade (P = 0.854). The most common complications were hypotension (n = 4) and transient left bundle branch block (n = 5). Overall 24-hour and 30-day mortality was 5% (n = 1) and 15% (n = 3), respectively. Within 30 days after PBAV procedure, five patients underwent successful sAVR, one patient underwent TAVR, and five patients awaited TAVR.
  
  
  CONCLUSIONS
  In high-risk patients with severe aortic stenosis and temporary contraindication to sAVR or TAVR, PBAV can be safely used as a bridging intervention procedure and the short-term procedural and clinic outcomes are satisfactory.
authors: Coronary Heart Disease Center, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors: Hanjun
authors: H
authors: Pei
authors: Email: fuwaihospital@gmail.com.
authors: Yongjian
authors: Y
authors: Wu
authors: Yuejin
authors: Y
authors: Yang
authors: Siyong
authors: S
authors: Teng
authors: Haitao
authors: H
authors: Zhang
authors: Lei
authors: L
authors: Zhang
authors: Hongxia
authors: H
authors: Niu
authors: Wenjia
authors: W
authors: Zhang
authors: Guannan
authors: G
authors: Niu
authors: Jie
authors: J
authors: Qian
authors: Shubin
authors: S
authors: Qiao
authors: Bo
authors: B
authors: Xu
authors: Runlin
authors: R
authors: Gao
mesh_terms: D001011:Aorta; D001021:Aortic Valve; D001022:Aortic Valve Insufficiency; D001024:Aortic Valve Stenosis / Q000628:therapy*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D062645:Percutaneous Coronary Intervention; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome