title: CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis.
abstract: BACKGROUND
  Recent meta-analyses show strong evidence of associations among genetic variants in CHRNA5 on chromosome 15q25, smoking quantity, and lung cancer. This meta-analysis tests whether the CHRNA5 variant rs16969968 predicts age of smoking cessation and age of lung cancer diagnosis.
  
  
  METHODS
  Meta-analyses examined associations between rs16969968, age of quitting smoking, and age of lung cancer diagnosis in 24 studies of European ancestry (n = 29 072). In each dataset, we used Cox regression models to evaluate the association between rs16969968 and the two primary phenotypes (age of smoking cessation among ever smokers and age of lung cancer diagnosis among lung cancer case patients) and the secondary phenotype of smoking duration. Heterogeneity across studies was assessed with the Cochran Q test. All statistical tests were two-sided.
  
  
  RESULTS
  The rs16969968 allele (A) was associated with a lower likelihood of smoking cessation (hazard ratio [HR] = 0.95, 95% confidence interval [CI] = 0.91 to 0.98, P = .0042), and the AA genotype was associated with a four-year delay in median age of quitting compared with the GG genotype. Among smokers with lung cancer diagnoses, the rs16969968 genotype (AA) was associated with a four-year earlier median age of diagnosis compared with the low-risk genotype (GG) (HR = 1.08, 95% CI = 1.04 to 1.12, P = 1.1*10(-5)).
  
  
  CONCLUSIONS
  These data support the clinical significance of the CHRNA5 variant rs16969968. It predicts delayed smoking cessation and an earlier age of lung cancer diagnosis in this meta-analysis. Given the existing evidence that this CHRNA5 variant predicts favorable response to cessation pharmacotherapy, these findings underscore the potential clinical and public health importance of rs16969968 in CHRNA5 in relation to smoking cessation success and lung cancer risk.
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Li-Shiun
authors: LS
authors: Chen
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Rayjean J
authors: RJ
authors: Hung
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Timothy
authors: T
authors: Baker
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Amy
authors: A
authors: Horton
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Rob
authors: R
authors: Culverhouse
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Nancy
authors: N
authors: Saccone
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Iona
authors: I
authors: Cheng
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Bo
authors: B
authors: Deng
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Younghun
authors: Y
authors: Han
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Helen M
authors: HM
authors: Hansen
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Janet
authors: J
authors: Horsman
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Claire
authors: C
authors: Kim
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Sharon
authors: S
authors: Lutz
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Albert
authors: A
authors: Rosenberger
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Katja K
authors: KK
authors: Aben
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Angeline S
authors: AS
authors: Andrew
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Naomi
authors: N
authors: Breslau
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Shen-Chih
authors: SC
authors: Chang
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Aida Karina
authors: AK
authors: Dieffenbach
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Hendrik
authors: H
authors: Dienemann
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Brittni
authors: B
authors: Frederiksen
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Jiali
authors: J
authors: Han
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Dorothy K
authors: DK
authors: Hatsukami
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Eric O
authors: EO
authors: Johnson
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Mala
authors: M
authors: Pande
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Margaret R
authors: MR
authors: Wrensch
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: John
authors: J
authors: McLaughlin
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Vidar
authors: V
authors: Skaug
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Henricus F
authors: HF
authors: van der Heijden
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Jason
authors: J
authors: Wampfler
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Angela
authors: A
authors: Wenzlaff
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Penella
authors: P
authors: Woll
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Shanbeh
authors: S
authors: Zienolddiny
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Heike
authors: H
authors: Bickeböller
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Hermann
authors: H
authors: Brenner
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Eric J
authors: EJ
authors: Duell
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Aage
authors: A
authors: Haugen
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Joachim
authors: J
authors: Heinrich
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: John E
authors: JE
authors: Hokanson
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: David J
authors: DJ
authors: Hunter
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Lambertus A
authors: LA
authors: Kiemeney
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Philip
authors: P
authors: Lazarus
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Loic
authors: L
authors: Le Marchand
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Geoffrey
authors: G
authors: Liu
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Jose
authors: J
authors: Mayordomo
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Angela
authors: A
authors: Risch
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Ann G
authors: AG
authors: Schwartz
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Dawn
authors: D
authors: Teare
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Xifeng
authors: X
authors: Wu
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: John K
authors: JK
authors: Wiencke
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Ping
authors: P
authors: Yang
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Zuo-Feng
authors: ZF
authors: Zhang
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Margaret R
authors: MR
authors: Spitz
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Peter
authors: P
authors: Kraft
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Christopher I
authors: CI
authors: Amos
authors: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO (LSC, AHo, LJB); The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO (LSC, LJB); Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada (RJH, JM); Tobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI (TB); Department of Medicine, Washington University School of Medicine, St. Louis, MO (RC); Department of Genetics, Washington University School of Medicine, St. Louis, MO (NS); Cancer Prevention Institute of California, Fremont, CA (IC); Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN (BD, JW, PY); Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH (YH, CIA); Department of Neurological Surgery, University of California San Francisco, San Francisco, CA (HMH, MRW, JKW); Department of Oncology, University of Sheffield, Sheffield, UK (JHo, PW); Department of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA (CK, ZFZ); Department of Biostatistics & Informatics, University of Colorado Anschutz Medical Campus, Denver, CO (SL); Department of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany (AR, HBi); Comprehensive Cancer Centre, the Netherlands, Utrecht, Netherland & Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands (KKA); Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (ASA); Department of Epidemiology, Michigan State University, East Lansing, MI (NB); Division of Clinical Epidemiology and Aging Research German Cancer Research Center, German Cancer research Center, Heidelberg, Germany (AKD, HBr); German Cancer Consortium, Heidelberg, Germany (AKD, HBr); Department of Thoracic Surgery, Thoraxklinik at University Hospital
authors: Laura J
authors: LJ
authors: Bierut
mesh_terms: D014644:Genetic Variation; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000209:etiology* / Q000235:genetics; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010641:Phenotype; D011978:Receptors, Nicotinic / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000235:genetics*; D016540:Smoking Cessation / Q000706:statistics & numerical data; D013997:Time Factors
chemical_list: C447158:CHRNA5 protein, human; D009419:Nerve Tissue Proteins; D011978:Receptors, Nicotinic