title: [Pathogenesis of systemic lupus erythematosus].
abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease with an extremely complex pathogenesis. Due to a genetic predisposition the disease can be induced by multiple stress factors involving epigenetic mechanisms and under the influence of the innate immune system. Defective clearance of immune complexes and apoptotic material together with enhanced neutrophil extracellular trap formation (NETosis) as well as up-regulation of type 1 interferon in particular, drive the adaptive immune system to a breakdown of self-tolerance. The result is a B cell hyperactivity, which leads to the generation of a multitude of different autoantibodies that are not only directed against nuclear antigens. Autoantibodies are the initiators for the involvement of many organs, which enhances further inflammatory cells and cytokines by participation of effector T-cells. Finally, an autoreactive immunological (plasma cell) memory is formed, which contributes to chronification and is associated with therapy-refractive courses of the disease. The depletion of the autoreactive immunological memory by immunoablation can lead to induction of self-tolerance and long-term remission.
authors: Medizinische Klinik m. S. Rheumatologie und Klinische Immunologie, Charité - Universitätsmedizin Berlin; Deutsches RheumaForschungszentrum Berlin - ein Institut der Leibniz-Gemeinschaft, Charitéplatz 1, 10117, Berlin, Deutschland.
authors: T
authors: T
authors: Alexander
authors: A
authors: A
authors: Radbruch
authors: F
authors: F
authors: Hiepe
mesh_terms: D001323:Autoantibodies / Q000235:genetics / Q000276:immunology*; D016207:Cytokines / Q000235:genetics* / Q000276:immunology*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology*; D008957:Models, Genetic; D018448:Models, Immunological
chemical_list: D001323:Autoantibodies; D016207:Cytokines