title: Autonomic imbalance assessed by time-domain heart rate variability indices in primary Raynaud's phenomenon.
abstract: OBJECTIVE
  The pathogenesis of primary Raynaud's phenomenon (RP) seems to be multifactorial and autonomic nervous dysfunction is one factor. Heart rate variability (HRV) is one of the most reliable parameters to demonstrate autonomic dysfunction. Our aim was to evaluate the time-domain HRV in patients with primary RP.
  
  
  METHODS
  A time analysis of HRV was performed in patients with primary RP and age- and gender-matched healthy controls. The results of the study and control group were compared.
  
  
  RESULTS
  Thirty patients with primary RP [all men, median (IQR) age: 21 (2) years) and 31 age- and gender-matched healthy controls (median (IQR): 21(3) years] were enrolled in the study. We found a statistically significant difference between the primary RP patients and control subjects in terms of time-domain HRV parameters (p < 0.05 for all).
  
  
  CONCLUSIONS
  Our study showed the presence of autonomic nervous dysfunction of heart function in patients with primary RP.
authors: Department of Cardiovascular Surgery, Gulhane Military Academy of Medicine, Ankara, Turkey.
authors: Kubilay
authors: K
authors: Karabacak
authors: Department of Cardiology, Gulhane Military Academy of Medicine, Ankara, Turkey.
authors: Murat
authors: M
authors: Celik
authors: Department of Cardiovascular Surgery, Gulhane Military Academy of Medicine, Ankara, Turkey.
authors: Erkan
authors: E
authors: Kaya
authors: Department of Cardiovascular Surgery, Gulhane Military Academy of Medicine, Ankara, Turkey.
authors: Murat
authors: M
authors: Kadan
authors: Department of Cardiovascular Surgery, Gulhane Military Academy of Medicine, Ankara, Turkey.
authors: Gokhan
authors: G
authors: Arslan
authors: Department of Cardiovascular Surgery, Gulhane Military Academy of Medicine, Ankara, Turkey.
authors: Ufuk
authors: U
authors: Demirkilic
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology*; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis / Q000503:physiopathology*; D016022:Case-Control Studies; D015716:Electrocardiography, Ambulatory; D006321:Heart / Q000294:innervation*; D006339:Heart Rate; D006801:Humans; D008297:Male; D011379:Prognosis; D011928:Raynaud Disease / Q000175:diagnosis / Q000503:physiopathology*; D013997:Time Factors; D055815:Young Adult