title: Yinchenhao decoction in the treatment of cholestasis: A systematic review and meta-analysis.
abstract: BACKGROUND
  Yinchenhao decoction, a well-known Chinese herbal formula, has been widely used in Chinese Medicine for thousands of years. However, no systematic review of Yinchenhao decoction in treating cholestasis has been completed. This study aims to evaluate the efficacy and safety of the Yinchenhao decoction in treating cholestasis.
  
  
  METHODS
  The major databases (PubMed, Embase, Cochrane Library, Chinese Biomedical Database, Wanfang database, VIP medicine information system and China National Knowledge Infrastructure) were searched from the databases' inception through November 2014. Randomized controlled trials (RCTs) of Yinchenhao decoction reported in publications for treatment of cholestasis were extracted by two reviewers. The RCTs examined included total efficacy rate and biochemical indices including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and direct bilirubin (DBIL). The Cochrane tool was applied to assess the risk of bias of the trials. The main outcomes of the trials were analyzed using Review Manager 5.3 software. The odds ratio (OR) or mean difference (MD) with a 95% confidence interval (CI) was used to measure the effect.
  
  
  RESULTS
  Among the 698 studies identified in the literature search, 15 studies involving 1405 subjects with cholestasis were included in the analysis. Yinchenhao decoction demonstrated efficacy in cholestasis treatment whether in a combined application or not. Additionally, the decoction significantly reduced the elevated levels of cholestasis serum markers, such as ALT, AST, TBIL and DBIL, with a significant difference observed in short and long curative time periods. Remarkably, Yinchenhao decoction displayed a significant efficacy in treating the long-term disease.
  
  
  CONCLUSIONS
  No serious adverse event was reported. This meta-analysis provides evidence that Yinchenhao decoction is an effective and safe treatment for cholestasis.
authors: China Military Institute of Chinese Medicine, Chengdu 611137, China; Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
authors: Zhe
authors: Z
authors: Chen
authors: China Military Institute of Chinese Medicine, Chengdu 611137, China; Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
authors: Xiao
authors: X
authors: Ma
authors: China Military Institute of Chinese Medicine, Chengdu 611137, China. Electronic address: zhaoyanl2855@163.com.
authors: Yanling
authors: Y
authors: Zhao
authors: China Military Institute of Chinese Medicine, Chengdu 611137, China.
authors: Jiabo
authors: J
authors: Wang
authors: China Military Institute of Chinese Medicine, Chengdu 611137, China.
authors: Yaming
authors: Y
authors: Zhang
authors: Department of Integrative Medical Center, 302 Military Hospital of China, Beijing 100039, China.
authors: Jianyu
authors: J
authors: Li
authors: Department of Integrative Medical Center, 302 Military Hospital of China, Beijing 100039, China.
authors: Ruilin
authors: R
authors: Wang
authors: Department of Integrative Medical Center, 302 Military Hospital of China, Beijing 100039, China.
authors: Yun
authors: Y
authors: Zhu
authors: Department of Integrative Medical Center, 302 Military Hospital of China, Beijing 100039, China.
authors: Lifu
authors: L
authors: Wang
authors: China Military Institute of Chinese Medicine, Chengdu 611137, China. Electronic address: xiaoxiaohe302@163.com.
authors: Xiaohe
authors: X
authors: Xiao
mesh_terms: D000818:Animals; D002779:Cholestasis / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008517:Phytotherapy; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; C579121:yinchenhao
keywords: Capillarisin (PubChem CID: 5281342); Capillene (PubChem CID: 6429143); Capillin (PubChem CID: 10321); Cholestasis; Efficacy; Genipin (PubChem CID: 442424); Geniposide (PubChem CID: 16760120); Meta-analysis; Paeoniflorin (Pubchem CID: 442534); Safety; Yinchenhao decoction