title: Expression of myeloid zinc finger 1 and the correlation to clinical aspects of oral squamous cell carcinoma.
abstract: The myeloid zinc finger 1 (MZF1) is a zinc finger transcription factor which regulates myeloid differentiation and oncogenesis. However, little information is available concerning the MZF1 expression in oral squamous cell carcinoma (OSCC) and its correlation with patients' prognosis. We detected the expression of MZF1 in 274 patients with OSCC using tissue microarrays (TMAs) and evaluated the associations between nuclear MZF1 expression and the clinical parameters of OSCC patients. We found that nuclear MZF1 expression was present in 190/274 (69.3 %) cases, and loss of nuclear expression of MZF1 was associated with more advanced clinical stages (p = 0.011) and larger tumor size (p = 0.002), but not associated with positive lymph node metastasis and distal metastasis. Importantly, tongue squamous cell carcinomas (SCC) patients with negative nuclear MZF1 expression had significantly worse overall survival rates (log-rank test, p = 0.028). In conclusion, our results revealed that the loss of nuclear expression of MZF1 in OSCC samples can predict the progression of OSCC and the survival of OSCC patients in Taiwan.
authors: Department of Neurosurgery, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan.|Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors: Chung-Po
authors: CP
authors: Ko
authors: School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.|Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors: Li-Chiu
authors: LC
authors: Yang
authors: Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan.|Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan.|School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors: Chih-Jung
authors: CJ
authors: Chen
authors: Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan.|Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan.|School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors: Kun-Tu
authors: KT
authors: Yeh
authors: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan.|Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan.
authors: Shu-Hui
authors: SH
authors: Lin
authors: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.|Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
authors: Shun-Fa
authors: SF
authors: Yang
authors: School of Medicine, Chung Shan Medical University, Taichung, Taiwan. 53780@cch.org.tw.|Department of Otorhinolaryngology-Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan. 53780@cch.org.tw.|Institute of Oral Sciences, Chung Shan Medical University, 110 Chien-Kuo, Section 1, N. Road, Taichung, 402, Taiwan. 53780@cch.org.tw.
authors: Mu-Kuan
authors: MK
authors: Chen
authors: Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan. cwlin@csmu.edu.tw.|Institute of Oral Sciences, Chung Shan Medical University, 110 Chien-Kuo, Section 1, N. Road, Taichung, 402, Taiwan. cwlin@csmu.edu.tw.
authors: Chiao-Wen
authors: CW
authors: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D051741:Kruppel-Like Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D013624:Taiwan; D046888:Tissue Array Analysis
chemical_list: D051741:Kruppel-Like Transcription Factors; C085969:MZF1 protein, human
keywords: MZF1; Oral squamous cell carcinoma; Prognosis; Tissue microarray