title: Evaluation of relationship between serum levels of anti-müllerian hormone, androgen, and insulin resistant with retrieval oocytes in overweight patients with polycystic ovary syndrome.
abstract: BACKGROUND
  This study aimed to find a correlation between increased body mass index (BMI), insulin resistance (IR), hyperandrogenism, and anti-mullerian hormone (AMH) serum levels with the number of follicles retrieved in polycystic ovary syndrome (PCOS) patients.
  
  
  METHODS
  The descriptive study was taken on 80 women with average ages of 20-35 years at Alzahra Hospital of Tabriz-Iran who referred for in vitro fertilization. Patients were divided into four groups and serum levels of AMH, testosterone and IR were evaluated at the puncture time.
  
  
  RESULTS
  The mean number of follicle retrieved was higher in PCOS (P < 0.05) group than non-PCOS patients. There was a negative significant correlation of follicle number with BMI (r = -0.26, P < 0.05). The ratio of follicle numbers in PCOS/overweight group decreased in comparison to PCOS/normal weight group (-30%, P < 0.05) while the follicle numbers in non-PCOS/overweight patients decreased in comparison with non-PCOS/normal weight (-26%, P > 0.05). There was a significant negative association between BMI with AMH (r = -0.59, P < 0.05), BMI with the follicle numbers (r = -0.2, P < 0.05) and a positive association BMI with -IR (r = 0.3, P < 0.05), but there wasn't a significant correlation between BMI with testosterone (r = 0.1, P < 0.5).
  
  
  CONCLUSIONS
  Our finding provides that increasing BMI with direct effect on AMH levels and IR can affect the number of follicles, which are retrieved in these patients.
authors: Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Research Center for Biochemistry and Nutrition In Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
authors: Esmat
authors: E
authors: Aghadavod
authors: Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Nosratollah
authors: N
authors: Zarghami
authors: Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Laya
authors: L
authors: Farzadi
authors: Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran ; Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Mina
authors: M
authors: Zare
authors: Research Center for Pharmaceutical Nanotechnology, Research and Development Complex, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Abolfazl
authors: A
authors: Barzegari
authors: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Ali Akbar
authors: AA
authors: Movassaghpour
authors: Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Mohammad
authors: M
authors: Nouri
keywords: Anti-mullerian hormone; follicles retrieved; insulin resistance; polycystic ovary syndrome; testosterone