title: Sarcoidosis: a single hospital-based study in a 24-year period.
abstract: BACKGROUND
  Clinical presentation of sarcoidosis varies according to race and geographical area. We describe the clinical spectrum and outcome of sarcoidosis in Mexican patients compared with other populations.
  
  
  METHODS
  We reviewed the medical charts of 21 patients with sarcoidosis seen at a referral hospital in 1989-2012; organ involvement was assessed using the ACCESS instrument. We compared our results with the ACCESS and Latin American studies. We used descriptive statistics and reported odd ratios with 95% CI.
  
  
  CONCLUSIONS
  Fifty-two percent were women; median age was 31 years; median time to diagnosis, 5.5 months. Frequency of organ involvement was: constitutional symptoms 62%, lungs 66.6%, skin 42.8%, bone marrow 23.4%, lymph node 19%, liver 19%, and eye 19%. After one year of follow-up, 47.5% of patients were asymptomatic without treatment, 38% asymptomatic on treatment, and 14.2% symptomatic on treatment. In our patients, pulmonary involvement was lower (66.6 vs. 94.9%; p = 0.001) and cutaneous (42.8 vs. 15.8%; p = 0.003) and bone marrow (23.4 vs. 4.7%; p = 0.001) were higher than in the ACCESS cohort. Data regarding Latin American populations was scarce. The clinical spectrum of sarcoidosis in our population differed from other studies, with a higher frequency of cutaneous sarcoidosis and less pulmonary involvement.
authors: Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Diego Luis
authors: DL
authors: Carrillo-Pérez
authors: Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Elia Ixel
authors: EI
authors: Apodaca-Cháveza
authors: Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Eduardo
authors: E
authors: Carrillo-Maravilla
authors: Department of Pneumology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Mayra
authors: M
authors: Mejía-Ávila
authors: Department of Cardio-Pneumology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: José Luis
authors: JL
authors: Hernández-Oropeza
authors: Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Edgardo
authors: E
authors: Reyes
authors: Department of Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Yemil
authors: Y
authors: Atisha-Fregoso
authors: Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Gabriela
authors: G
authors: Hernández-Molina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001855:Bone Marrow Diseases / Q000473:pathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000503:physiopathology / Q000628:therapy*; D017565:Sarcoidosis, Pulmonary / Q000473:pathology / Q000628:therapy*; D012871:Skin Diseases / Q000473:pathology / Q000628:therapy*; D055815:Young Adult