title: Overactive bladder in adults with sickle cell disease.
abstract: To characterize the prevalence and impact of nocturnal enuresis and overactive bladder (OAB) symptomatology in the adult sickle-cell disease (SCD) population.
  
  
  
  We performed a single-center, cross-sectional study of adult SCD patients from October 2012 to February 2014, using the validated Pfizer OAB short form questionnaire and brief voiding history surveys. Patient responses and scores were compared to that of controls having normal or sickle cell trait hemoglobin genotypes.
  
  
  
  A group of 239 SCD patients (116 males, 123 females) were compared with 104 normal and 57 sickle cell trait patients. Seven of 239 (2.9%) SCD patients compared to none of the 161 patients without SCD (P = 0.04) reported current nocturnal enuresis. The median age of nocturnal enuresis cessation was higher in SCD patients (12.0, IQR 9.0-15.0 years) compared to that of both normal (7.5, IQR 6.0-9.8 years) and sickle cell trait (7.5, IQR 6.0-8.8 years) groups (P < 0.0001). Ninety-three of 239 (38.9%) SCD patients compared to 17 of 104 (16.3%) normal and 11 of 57 (19.3%) sickle cell trait had scores indicating OAB symptomatology (P < 0.0001). Patients with SCD had higher OAB symptom severity and lower health-related quality of life (HRQL) scores compared to the normal and sickle cell trait groups (P < 0.0001 and P < 0.0001, respectively).
  
  
  
  We demonstrate an elevated rate of nocturnal enuresis and OAB symptoms in the adult SCD population. An OAB phenotype may be an under-recognized complication of SCD irrespective of age. Neurourol. Urodynam. 35:642-646, 2016. © 2015 Wiley Periodicals, Inc.
authors: The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Uzoma A
authors: UA
authors: Anele
authors: Department of Surgery, University of the West Indies, Mona, Jamaica.
authors: Belinda F
authors: BF
authors: Morrison
authors: Sickle Cell Unit, University of the West Indies, Mona, Jamaica.
authors: Marvin E
authors: ME
authors: Reid
authors: Sickle Cell Unit, University of the West Indies, Mona, Jamaica.
authors: Wendy
authors: W
authors: Madden
authors: Sickle Cell Unit, University of the West Indies, Mona, Jamaica.
authors: Shara
authors: S
authors: Foster
authors: The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors: Arthur L
authors: AL
authors: Burnett
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007563:Jamaica / Q000453:epidemiology; D008297:Male; D053206:Nocturnal Enuresis / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D011795:Surveys and Questionnaires; D053201:Urinary Bladder, Overactive / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult
keywords: epidemiology; nocturnal enuresis; population-based; prevalence; quality of life