title: BTNL2 gene polymorphism and sarcoidosis susceptibility: a meta-analysis.
abstract: BACKGROUND
  Butyrophilin-like 2 (BTNL2) rs2076530 gene polymorphism has been implicated in susceptibility to sarcoidosis. However, results from previous studies are not consistent. To assess the association of BTNL2 polymorphism and sarcoidosis susceptibility, a meta-analysis was performed.
  
  
  METHODS
  PubMed, Embase were searched for eligible case-control studies. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Ten studies involving a total of 3303 cases and 2514 controls were included in this meta-analysis. Combined data indicated that BTNL2 rs2076530 polymorphism was associated with sarcoidosis susceptibility in allelic model (A vs. G, OR = 1.59, 95%CI: 1.47-1.72), dominant model (AA + AG vs. GG, OR = 2.10, 95%CI: 1.67-2.65), and recessive model (AA vs. AG + GG, OR = 1.93, 95%CI: 1.49-2.50).
  
  
  CONCLUSIONS
  This meta-analysis indicates that BTNL2 rs2076530 polymorphism contributes to the risk of sarcoidosis.
authors: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Department of Respiratory Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
authors: Yihua
authors: Y
authors: Lin
authors: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors: Jia
authors: J
authors: Wei
authors: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors: Lili
authors: L
authors: Fan
authors: Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors: Deyun
authors: D
authors: Cheng
mesh_terms: D000071797:Butyrophilins; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012507:Sarcoidosis / Q000235:genetics*
chemical_list: C408263:BTNL2 protein, human; D000071797:Butyrophilins; D008562:Membrane Glycoproteins