title: Comparison of Two Commercial Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Modified Live Vaccines against Heterologous Type 1 and Type 2 PRRSV Challenge in Growing Pigs.
abstract: The objective of the present study was to compare the efficacy of two commercial type 1 porcine reproductive and respiratory syndrome virus (PRRSV) modified live vaccines against heterologous type 1 and type 2 PRRSV challenge in growing pigs. Vaccination with a type 1 PRRSV vaccine reduced the level of viremia after type 1 PRRSV challenge but did not reduce the level of viremia after the type 2 PRRSV challenge in pigs. Increased levels of interleukin-10 (IL-10) stimulated by type 2 PRRSV coincided with the low numbers of type 2 PRRSV-specific interferon gamma-secreting cells (IFN-γ-SC) in vaccinated pigs after type 2 PRRSV challenge, whereas low levels of IL-10 stimulated by type 1 PRRSV coincided with high numbers of type 1 PRRSV-specific IFN-γ-SC in vaccinated pigs after type 1 PRRSV challenge. Additionally, vaccination with the type 1 PRRSV vaccine effectively reduced the lung lesions and type 1 PRRSV nucleic acids in type 1 PRRSV-challenged pigs but did not reduce lung lesions and type 2 PRRSV nucleic acids in type 2 PRRSV-challenged pigs. There were no significant differences between two commercial type 1 PRRSV vaccines against type 1 and type 2 PRRSV challenge based on virological results, immunological responses, and pathological outcomes. This study demonstrates that vaccinating pigs with the type 1 PRRSV vaccine provides partial protection against respiratory disease with heterologous type 1 PRRSV challenge but no protection with heterologous type 2 PRRSV challenge.
authors: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
authors: Taeyeon
authors: T
authors: Kim
authors: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
authors: Changhoon
authors: C
authors: Park
authors: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
authors: Kyuhyung
authors: K
authors: Choi
authors: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
authors: Jiwoon
authors: J
authors: Jeong
authors: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
authors: Ikjae
authors: I
authors: Kang
authors: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Republic of Korea.
authors: Su-Jin
authors: SJ
authors: Park
authors: Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Gwanak-gu, Seoul, Republic of Korea swine@snu.ac.kr.
authors: Chanhee
authors: C
authors: Chae
mesh_terms: D000818:Animals; D056738:Cross Protection; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008168:Lung / Q000473:pathology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000276:immunology / Q000517:prevention & control*; D019316:Porcine respiratory and reproductive syndrome virus / Q000235:genetics / Q000276:immunology*; D013552:Swine; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D014766:Viremia / Q000517:prevention & control
chemical_list: D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic; D014765:Viral Vaccines; D016753:Interleukin-10; D007371:Interferon-gamma