title: C-erbB-2 expression and prognosis of gastric cancer: a meta-analysis.
abstract: The prognostic role of c-erbB-2 in gastric cancer is controversial. We conducted a meta-analysis to evaluate the relationship between c-erbB-2 expression and the prognosis of gastric cancer. We evaluated 20 published studies assessing the relationship between c-erbB-2 and gastric cancer prognosis. The Revman 5.0 software was used to perform literature retrieval, article selection, data collection, and statistical analysis. We utilized a fixed-effect model to pool hazard ratios and 95% confidence intervals from the studies. A total of 20 eligible studies including 4468 gastric cancer patients were analyzed. We were unable to demonstrate the prognostic value of c-erbB-2 for gastric cancer (hazard ratio = 1.01, 95% confidence interval = 0.87-1.16, P = 0.93). The present study indicated that c-erbB-2 expression is not a prognostic factor for gastric cancer.
authors: Department of Surgery, Affiliated Tongren Hospital, Shanghai Jiaotong University, Shanghai, China.
authors: Z Q
authors: ZQ
authors: Wang
authors: Department of Surgery, Affiliated Tongren Hospital, Shanghai Jiaotong University, Shanghai, China sunbaojun1976@yeah.net.
authors: B J
authors: BJ
authors: Sun
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000235:genetics*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human