title: Dissemination of the same cfr-carrying plasmid among methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococcal isolates in China.
abstract: Six cfr-harboring methicillin-resistant Staphylococcus aureus (MRSA) isolates, which belonged to the same clone of sequence type 5 (ST5)-staphylococcal cassette chromosome mec element II (SCCmec II)-spa t311, were investigated in this study. Complete sequencing of a cfr-carrying plasmid, pLRSA417, revealed an 8,487-bp fragment containing a Tn4001-like transposon, cfr, orf1, and ISEnfa4. This segment, first identified in an animal plasmid, pSS-01, was observed in several plasmids from clinical coagulase-negative staphylococci in China, suggesting that the cfr gene, which might originate from livestock, was located in the same mobile element and disseminated among different clinical staphylococcal species.
authors: The 2 Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China.
authors: Jia Chang
authors: JC
authors: Cai
authors: The 2 Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China.
authors: Yan Yan
authors: YY
authors: Hu
authors: The 2 Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China.
authors: Hong Wei
authors: HW
authors: Zhou
authors: The 2 Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China.
authors: Gong-Xiang
authors: GX
authors: Chen
authors: The 2 Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, People's Republic of China brigitte_zx@163.com.
authors: Rong
authors: R
authors: Zhang
mesh_terms: D002681:China; D002876:Chromosomes, Bacterial / Q000235:genetics; D003030:Coagulase / Q000235:genetics / Q000378:metabolism*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics; D010957:Plasmids / Q000235:genetics; D013210:Staphylococcus / Q000187:drug effects* / Q000235:genetics
chemical_list: D003030:Coagulase