title: [Chemical libraries dedicated to protein-protein interactions].
abstract: The identification of complete networks of protein-protein interactions (PPI) within a cell has contributed to major breakthroughs in understanding biological pathways, host-pathogen interactions and cancer development. As a consequence, PPI have emerged as a new class of promising therapeutic targets. However, they are still considered as a challenging class of targets for drug discovery programs. Recent successes have allowed the characterization of structural and physicochemical properties of protein-protein interfaces leading to a better understanding of how they can be disrupted with small molecule compounds. In addition, characterization of the profiles of PPI inhibitors has allowed the development of PPI-focused libraries. In this review, we present the current efforts at developing chemical libraries dedicated to these innovative targets.
authors: Molécules thérapeutiques in silico (MTi), université Paris Diderot, Inserm UMR-S973, 35, rue Hélène Brion, 75205 Paris Cedex 13, France.
authors: Olivier
authors: O
authors: Sperandio
authors: Molécules thérapeutiques in silico (MTi), université Paris Diderot, Inserm UMR-S973, 35, rue Hélène Brion, 75205 Paris Cedex 13, France.
authors: Bruno O
authors: BO
authors: Villoutreix
authors: Centre de recherche en cancérologie de Marseille (CRCM), CNRS UMR7258 ; Inserm U1068 ; institut Paoli-Calmettes ; université d'Aix-Marseille UM105, 27, boulevard Lei Roure,13009, Marseille, France.
authors: Xavier
authors: X
authors: Morelli
authors: Centre de recherche en cancérologie de Marseille (CRCM), CNRS UMR7258 ; Inserm U1068 ; institut Paoli-Calmettes ; université d'Aix-Marseille UM105, 27, boulevard Lei Roure,13009, Marseille, France.
authors: Philippe
authors: P
authors: Roche
mesh_terms: D000818:Animals; D003132:Commerce; D055808:Drug Discovery / Q000191:economics / Q000379:methods*; D006801:Humans; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods; D015398:Signal Transduction; D054852:Small Molecule Libraries / Q000191:economics / Q000378:metabolism*
chemical_list: D054852:Small Molecule Libraries