title: Chiral gold phosphate catalyzed tandem hydroamination/asymmetric transfer hydrogenation enables access to chiral tetrahydroquinolines.
abstract: A highly efficient chiral gold phosphate-catalyzed tandem hydroamination/asymmetric transfer hydrogenation reaction is described. A series of chiral tetrahydroquinolines were obtained in excellent yields and enantioselectivities. In this reaction, the gold catalyst enables both the hydroamination step as a π-Lewis acid and the asymmetric hydrogen-transfer process as an effective chiral Lewis acid.
authors: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors: Yu-Liu
authors: YL
authors: Du
authors: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors: Yue
authors: Y
authors: Hu
authors: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors: Yi-Fan
authors: YF
authors: Zhu
authors: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors: Xi-Feng
authors: XF
authors: Tu
authors: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors: Zhi-Yong
authors: ZY
authors: Han
authors: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors: Liu-Zhu
authors: LZ
authors: Gong
mesh_terms: D000586:Amination; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D006865:Hydrogenation; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010710:Phosphates; D011804:Quinolines; D006046:Gold; C542964:1,2,3,4-tetrahydroquinoline