title: Influence of circadian blood pressure profile on endothelial function in patients with and without arterial hypertension.
abstract: Little is known about the relationship between the circadian BP rhythm and endothelial function in patients with essential hypertension. Consequently, we have hypothesized, that hypertensive patients with non-dipper circadian BP profile have more deteriorated endothelial function, than those with dipper BP profile. 57 untreated hypertensive patients and 17 normotensive controls were undergone to the anthropometrical measurements, physical examinations, review of their medical histories, 24-hour ABPM and vascular doppler-echography with high resolution ultrasound. Circadian BP profile was not independent from the BP level; namely, dipper profile was more frequent in normotensives. Independent from hypertension, dipper patients had significantly higher FMD%. In the whole study population, FMD showed strong negative correlation with 24-hour SBP, DBP and PP. Our study confirms the presence of disturbed endothelium-dependent vasodilatation in AH. Furthermore, our study showed that non-dipper circadian BP rhythm is associated with the significant impairment of endothelial function. Consequently, we can suggest that patients with non-dipper circadian BP profile could be assessed as a high risk group, which might need permanent supervising for avoiding of future cardiovascular and cerebrovascular complications.
authors: Archangel St. Michael Multiprofile Clinical Hospital; Shotadze Tbilisi Medical Academy, Georgia.
authors: A
authors: A
authors: Rekhviashvili
authors: Archangel St. Michael Multiprofile Clinical Hospital; Shotadze Tbilisi Medical Academy, Georgia.
authors: T
authors: T
authors: Giorgobiani
authors: Archangel St. Michael Multiprofile Clinical Hospital; Shotadze Tbilisi Medical Academy, Georgia.
authors: A
authors: A
authors: Minashvili
authors: Archangel St. Michael Multiprofile Clinical Hospital; Shotadze Tbilisi Medical Academy, Georgia.
authors: E
authors: E
authors: Baganashvili
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D015150:Echocardiography, Doppler; D004727:Endothelium / Q000000981:diagnostic imaging / Q000503:physiopathology*; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012307:Risk Factors; D014664:Vasodilation / Q000502:physiology