title: Rituximab-combination chemotherapy achieves a 10th cycle of remission for Burkitt's lymphoma.
abstract: A 14-year-old girl with multiple intra-abdominal tumors was diagnosed with stage III Burkitt's lymphoma. She achieved complete remission after multi-drug chemotherapy, but she relapsed after six courses. Autologous peripheral blood stem cells (PBSC) or allogeneic PBSC harvested from an HLA-identical sibling were insufficient, and her family did not agree to bone marrow collection from the sibling. Although the patient relapsed nine times (the relapses involved intra-abdominal organs or bone) during the following 4 years 7 months, treatment with rituximab monotherapy or in combination with ifosphamide, carboplastin, and etoposide, or local irradiation (33.8-40.0 Gy) to treat the bone metastases, proved effective, resulting in complete or partial remission. At the time of writing, the patient was in a 10th cycle of remission lasting 1 year 6 months and had not required transplantation. Thus, a chemotherapy regimen including rituximab might be effective for Burkitt's lymphoma in patients experiencing multiple relapse.
authors: Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors: Katsutsugu
authors: K
authors: Umeda
authors: Hisanori
authors: H
authors: Fujino
authors: Satoshi
authors: S
authors: Saida
authors: Itaru
authors: I
authors: Kato
authors: Hidefumi
authors: H
authors: Hiramatsu
authors: Tomomi
authors: T
authors: Yamada
authors: Toshinori
authors: T
authors: Hori
authors: Souichi
authors: S
authors: Adachi
authors: Toshio
authors: T
authors: Heike
authors: Ken-ichiro
authors: K
authors: Watanabe
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002051:Burkitt Lymphoma / Q000188:drug therapy* / Q000473:pathology; D016190:Carboplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D009367:Neoplasm Staging; D010880:Piperidines / Q000008:administration & dosage; D012074:Remission Induction; D000069283:Rituximab / Q000008:administration & dosage
chemical_list: D010880:Piperidines; D000069283:Rituximab; D005047:Etoposide; D016190:Carboplatin; C046382:ifoxetine
keywords: Burkitt's lymphoma; chemotherapy; relapse; rituximab