title: Self-templated chemically stable hollow spherical covalent organic framework.
abstract: Covalent organic frameworks are a family of crystalline porous materials with promising applications. Although active research on the design and synthesis of covalent organic frameworks has been ongoing for almost a decade, the mechanisms of formation of covalent organic frameworks crystallites remain poorly understood. Here we report the synthesis of a hollow spherical covalent organic framework with mesoporous walls in a single-step template-free method. A detailed time-dependent study of hollow sphere formation reveals that an inside-out Ostwald ripening process is responsible for the hollow sphere formation. The synthesized covalent organic framework hollow spheres are highly porous (surface area ∼1,500 m(2 )g(-1)), crystalline and chemically stable, due to the presence of strong intramolecular hydrogen bonding. These mesoporous hollow sphere covalent organic frameworks are used for a trypsin immobilization study, which shows an uptake of 15.5 μmol g(-1) of trypsin.
authors: 1] Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India [2] Academy of Scientific and Innovative Research (AcSIR), New Delhi 110 025, India.
authors: Sharath
authors: S
authors: Kandambeth
authors: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India.
authors: V
authors: V
authors: Venkatesh
authors: Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India.
authors: Digambar B
authors: DB
authors: Shinde
authors: 1] Academy of Scientific and Innovative Research (AcSIR), New Delhi 110 025, India [2] Chemical Engineering and Process Development, CSIR-National Chemical Laboratory, Dr Homi Bhabha Road, Pune 411 008, India.
authors: Sushma
authors: S
authors: Kumari
authors: 1] Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India [2] Academy of Scientific and Innovative Research (AcSIR), New Delhi 110 025, India.
authors: Arjun
authors: A
authors: Halder
authors: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India.
authors: Sandeep
authors: S
authors: Verma
authors: 1] Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India [2] Academy of Scientific and Innovative Research (AcSIR), New Delhi 110 025, India.
authors: Rahul
authors: R
authors: Banerjee
mesh_terms: D000840:Anisoles / Q000737:chemistry*; D003460:Crystallization; D004800:Enzymes, Immobilized / Q000737:chemistry*; D006860:Hydrogen Bonding; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D010316:Particle Size; D016062:Porosity; D013499:Surface Properties; D013730:Terphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D014357:Trypsin / Q000737:chemistry*
chemical_list: D000840:Anisoles; D004800:Enzymes, Immobilized; D009570:Nitriles; D013730:Terphenyl Compounds; C031200:1,4-dimethoxybenzene; D014357:Trypsin