title: Plant derived and dietary phenolic antioxidants: anticancer properties.
abstract: In this paper, a review of the literature on the phenolic compounds with anticancer activity published between 2008 and 2012 is presented. In this overview only phenolic antioxidant compounds that display significant anticancer activity have been described. In the first part of this review, the oxidative and nitrosative stress relation with cancer are described. In the second part, the plant-derived food extracts, containing identified phenolic antioxidants, the phenolic antioxidants isolated from plants and plant-derived food or commercially available and the synthetic ones, along with the type of cancer and cells where they exert anticancer activity, are described and summarized in tables. The principal mechanisms for their anti-proliferative effects were also described. Finally, a critical analysis of the studies and directions for future research are included in the conclusion.
authors: CEF, Center for Pharmaceutical Studies, Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. Electronic address: froleira@ff.uc.pt.
authors: Fernanda M F
authors: FM
authors: Roleira
authors: CEF, Center for Pharmaceutical Studies, Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.
authors: Elisiário J
authors: EJ
authors: Tavares-da-Silva
authors: CEF, Center for Pharmaceutical Studies, Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.
authors: Carla L
authors: CL
authors: Varela
authors: CEF, Center for Pharmaceutical Studies, Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.
authors: Saul C
authors: SC
authors: Costa
authors: CIQUP/Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Portugal.
authors: Tiago
authors: T
authors: Silva
authors: CIQUP/Departamento de Engenharia Química, Instituto Superior de Engenharia, IPP, Porto, Portugal.
authors: Jorge
authors: J
authors: Garrido
authors: CIQUP/Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Portugal. Electronic address: fborges@fc.up.pt.
authors: Fernanda
authors: F
authors: Borges
mesh_terms: D016588:Anticarcinogenic Agents / Q000032:analysis*; D000975:Antioxidants / Q000032:analysis*; D006801:Humans; D010084:Oxidation-Reduction; D010636:Phenols / Q000032:analysis*; D010936:Plant Extracts / Q000737:chemistry*; D010945:Plants, Edible / Q000737:chemistry*
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D010636:Phenols; D010936:Plant Extracts
keywords: Cancer; Dietary phenolic antioxidants; Synthetic phenolic antioxidants