title: [Expressions and significance of NDRG2 and Bcl-2 in human gastric cancer tissues].
abstract: OBJECTIVE
  To analyze the expressions of N-myc downstream regulated gene 2 (NDRG2) and B cell lymphoma/leukemia-2 (Bcl-2) in human gastric cancer in an attempt to explore their correlation and clinical significance.
  
  
  METHODS
  Immunohistochemical staining was used to detect the expression of NDRG2 and Bcl-2 in human gastric cancer, para-carcinoma tissues and normal tissues. The correlation between their expressions and clinicopathologic data were analyzed using statistical software in gastric cancer tissues.
  
  
  RESULTS
  The tissue microarray consisting of 64 gastric cancer and 10 normal gastric tissues showed NDRG2 expression in gastric cancer tissues was significantly lower than that in normal tissues, whereas Bcl-2 expression in gastric cancer tissues was significantly higher than that in normal tissues. It was also indicated that NDRG2 was negatively correlated with Bcl-2 in gastric cancer tissues. NDRG2 and Bcl-2 were further analyzed in 206 gastric cancer and paired para-carcinoma tissues. It was displayed that the expression levels of NDRG2 and Bcl-2 in human gastric cancer were not associated with age and sex, but significantly associated with tumor differentiation, clinical stage and lymph node metastasis.
  
  
  CONCLUSIONS
  There is a negative correlation between NDRG2 and Bcl-2 expressions in human gastric cancer, suggesting they might be synergistically involved in the development of gastric cancer.
authors: Department of Digestive Diseases, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
authors: Ruixue
authors: R
authors: Zhu
authors: Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an 710032, China.
authors: Yongquan
authors: Y
authors: Shi
authors: Department of Digestive Diseases, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
authors: Lianfeng
authors: L
authors: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: C466228:NDRG2 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D025521:Tumor Suppressor Proteins