title: Active targeted drug delivery for microbes using nano-carriers.
abstract: Although vaccines and antibiotics could kill or inhibit microbes, many infectious diseases remain difficult to treat because of acquired resistance and adverse side effects. Nano-carriers-based technology has made significant progress for a long time and is introducing a new paradigm in drug delivery. However, it still has some challenges like lack of specificity toward targeting the infectious site. Nanocarriers utilized targeting ligands on their surface called 'active target' provide the promising way to solve the problems like accelerating drug delivery to infectious areas and preventing toxicity or side-effects. In this mini review, we demonstrate the recent studies using the active targeted strategy to kill or inhibit microbes. The four common nano-carriers (e.g. liposomes, nanoparticles, dendrimers and carbon nanotubes) delivering encapsulated drugs are introduced.
authors: Yung-Sheng
authors: YS
authors: Lin
authors: Ming-Yuan
authors: MY
authors: Lee
authors: Chih-Hui
authors: CH
authors: Yang
authors: The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan. huangks@isu.edu.tw.
authors: Keng-Shiang
authors: KS
authors: Huang
mesh_terms: D000818:Animals; D003141:Communicable Diseases / Q000188:drug therapy; D050091:Dendrimers / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D008024:Ligands; D008081:Liposomes / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D008024:Ligands; D008081:Liposomes; D037742:Nanotubes, Carbon