title: Angiogenesis in bronchial asthma.
abstract: Bronchial asthma is a chronic inflammatory disease characterised by airflow obstruction that may be reversed spontaneously or in response to treatment. The airway inflammation can lead to structural changes and remodelling consisting of subepithelial layer thickening, airway smooth muscle hyperplasia and angiogenesis. Subepithelial hypervascularity and angiogenesis in the airways are part of the structural airway wall in asthma. Increased vascularity of bronchial mucosa is closely related to the expression of angiogenic factors like vascular endothelial growth factor (VEGF), angiopoietin and hypoxia-inducible factor (HIF). The scope of the present review is to summarise the roles of anagiogenic factors and treatment in vascular development.
authors: Department of Allergology, Clinical Immunology and Internal Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University of Toruń, Poland palgank@wp.pl.
authors: Krzysztof
authors: K
authors: Pałgan
authors: Department of Allergology, Clinical Immunology and Internal Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University of Toruń, Poland.
authors: Zbigniew
authors: Z
authors: Bartuzi
mesh_terms: D000818:Animals; D001249:Asthma / Q000378:metabolism / Q000473:pathology*; D001980:Bronchi / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A
keywords: HIF; VEGF; angiogenesis; angiopoietin; asthma