title: The relation of saturated fats and dietary cholesterol to childhood cognitive flexibility.
abstract: Identification of health behaviors and markers of physiological health associated with childhood cognitive function has important implications for public health policy targeted toward cognitive health throughout the life span. Although previous studies have shown that aerobic fitness and obesity exert contrasting effects on cognitive flexibility among prepubertal children, the extent to which diet plays a role in cognitive flexibility has received little attention. Accordingly, this study examined associations between saturated fats and cholesterol intake and cognitive flexibility, assessed using a task switching paradigm, among prepubertal children between 7 and 10 years (N = 150). Following adjustment of confounding variables (age, sex, socioeconomic status, IQ, VO2max, and BMI), children consuming diets higher in saturated fats exhibited longer reaction time during the task condition requiring greater amounts of cognitive flexibility. Further, increasing saturated fat intake and dietary cholesterol were correlated with greater switch costs, reflecting impaired ability to maintain multiple task sets in working memory and poorer efficiency of cognitive control processes involved in task switching. These data are among the first to indicate that children consuming diets higher in saturated fats and cholesterol exhibit compromised ability to flexibly modulate their cognitive operations, particularly when faced with greater cognitive challenge. Future longitudinal and intervention studies are necessary to comprehensively characterize the interrelationships between diet, aerobic fitness, obesity, and children's cognitive abilities.
authors: Department of Kinesiology and Community Health, University of Illinois, Urbana, IL. Electronic address: nakhan2@illinois.edu.
authors: Naiman A
authors: NA
authors: Khan
authors: Department of Kinesiology and Community Health, University of Illinois, Urbana, IL.
authors: Lauren B
authors: LB
authors: Raine
authors: Department of Kinesiology and Community Health, University of Illinois, Urbana, IL.
authors: Eric S
authors: ES
authors: Drollette
authors: Department of Kinesiology and Community Health, University of Illinois, Urbana, IL.
authors: Mark R
authors: MR
authors: Scudder
authors: Department of Kinesiology and Community Health, University of Illinois, Urbana, IL.
authors: Charles H
authors: CH
authors: Hillman
mesh_terms: D002648:Child; D002664:Child Nutritional Physiological Phenomena; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000209:etiology*; D004041:Dietary Fats / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*; D013647:Task Performance and Analysis
chemical_list: D002791:Cholesterol, Dietary; D004041:Dietary Fats
keywords: Aerobic fitness; Children; Cognitive flexibility; Diet; Obesity