title: [The role of introns in evolution].
abstract: The article describes the role of introns in eukaryotic evolution. Polymorhpsms generated in intronic regions included in the reading frame splice isoforms can alter the properties of the alternative product. It provides a framework to adapt to changing conditions of life. This is the basis for the adaptation of eukaryotes to changing conditions of life, that by evolution is fixed at the level of populations and species. The article describes the mechanisms of the dynamics properties of the eukaryotic genome, and the role of associative combinations in the genesis of multifactorial diseases.
authors: R N
authors: RN
authors: Mustafin
authors: E K
authors: EK
authors: Khusnutdinova
mesh_terms: D000222:Adaptation, Physiological; D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D007438:Introns / Q000235:genetics*; D011110:Polymorphism, Genetic