title: γδ T cells in infection and autoimmunity.
abstract: Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers and require different cytokine signaling to maintain the homeostasis. In addition, as the major innate IL-17 producers, γδ T cells are increasingly appreciated for their involvement in various acute infections and injuries. This review will summarize the characteristics of IFN-γ(+) (γδ T-IFN-γ) and IL-17(+) γδ T cells (γδT17) and discuss their distinct pathogenic functions in different disease models.
authors: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA. Electronic address: Lifei.Hou@childrens.harvard.edu.
authors: Lifei
authors: L
authors: Hou
authors: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA.
authors: Tian
authors: T
authors: Wang
authors: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA. Electronic address: jisun@utmb.edu.
authors: Jiaren
authors: J
authors: Sun
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D016207:Cytokines
keywords: Autoimmunity; IFN-γ; IL-17; Infection; γδ T cells