title: Clozapine induced akathisia: a case report and review of the evidence.
abstract: Clozapine is a second-generation antipsychotic medication, which is mostly used in patients with treatment resistant schizophrenia. It is considered to be associated with lower incidence of extrapyramidal side-effects. Akathisia is considered to be a rare side-effect of clozapine. In this report, we describe a patient who developed akathisia while receiving clozapine and review the literature. Existing literature suggests that except for few initial reports, data suggests that clozapine is in general associated with lower incidence of akathisia compared to first generation antipsychotics. Data comparing clozapine with other atypical antipsychotics is equivocal.
authors: Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors: Sandeep
authors: S
authors: Grover
authors: Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors: Swapnajeet
authors: S
authors: Sahoo
mesh_terms: D000328:Adult; D017109:Akathisia, Drug-Induced / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine
keywords: Akathisia; clozapine; extrapyramidal side effects