title: Bootstrap testing for cross-correlation under low firing activity.
abstract: A new cross-correlation synchrony index for neural activity is proposed. The index is based on the integration of the kernel estimation of the cross-correlation function. It is used to test for the dynamic synchronization levels of spontaneous neural activity under two induced brain states: sleep-like and awake-like. Two bootstrap resampling plans are proposed to approximate the distribution of the test statistics. The results of the first bootstrap method indicate that it is useful to discern significant differences in the synchronization dynamics of brain states characterized by a neural activity with low firing rate. The second bootstrap method is useful to unveil subtle differences in the synchronization levels of the awake-like state, depending on the activation pathway.
authors: MODES, Centro de Investigacións en Tecnoloxías da Información e as Comunicacións (CITIC), Departamento de Matemáticas, Facultade de Informática, Universidade da Coruña, Campus de A Coruña, 15071, A Coruña, Spain, agonzalezmo@udc.es.
authors: Aldana M
authors: AM
authors: González-Montoro
authors: Ricardo
authors: R
authors: Cao
authors: Nelson
authors: N
authors: Espinosa
authors: Javier
authors: J
authors: Cudeiro
authors: Jorge
authors: J
authors: Mariño
mesh_terms: D000200:Action Potentials; D000465:Algorithms; D000818:Animals; D001921:Brain / Q000502:physiology*; D002415:Cats; D003198:Computer Simulation; D003344:Cortical Synchronization; D004567:Electrodes, Implanted; D004569:Electroencephalography; D055724:Electrophysiological Phenomena / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D016012:Poisson Distribution; D012890:Sleep / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology; D014851:Wakefulness / Q000502:physiology