title: A resource for cell line authentication, annotation and quality control.
abstract: Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid cross-contamination, present a framework for cell line annotation linked to short tandem repeat and single nucleotide polymorphism profiles, and provide a catalogue of synonymous cell lines. This resource will enable our community to eradicate the use of misidentified lines and generate credible cell-based data.
authors: Department of Discovery Oncology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Mamie
authors: M
authors: Yu
authors: Department of Discovery Oncology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Suresh K
authors: SK
authors: Selvaraj
authors: Department of Discovery Oncology, Genentech Inc., South San Francisco, California 94080, USA.
authors: May M Y
authors: MM
authors: Liang-Chu
authors: Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Sahar
authors: S
authors: Aghajani
authors: Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Matthew
authors: M
authors: Busse
authors: Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Jean
authors: J
authors: Yuan
authors: Department of Discovery Oncology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Genee
authors: G
authors: Lee
authors: Department of Pathology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Franklin
authors: F
authors: Peale
authors: Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Christiaan
authors: C
authors: Klijn
authors: Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Richard
authors: R
authors: Bourgon
authors: Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Joshua S
authors: JS
authors: Kaminker
authors: Department of Discovery Oncology, Genentech Inc., South San Francisco, California 94080, USA.
authors: Richard M
authors: RM
authors: Neve
mesh_terms: D002460:Cell Line / Q000145:classification* / Q000378:metabolism*; D002469:Cell Separation; D066289:Data Curation; D005838:Genotype; D017408:Guidelines as Topic; D018895:Microsatellite Repeats / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011786:Quality Control; D015203:Reproducibility of Results; D013045:Species Specificity; D009626:Terminology as Topic