title: Chronic kidney disease influences multiple systems: describing the relationship between oxidative stress, inflammation, kidney damage, and concomitant disease.
abstract: Chronic kidney disease (CKD) is characterized by increased levels of oxidative stress and inflammation. Oxidative stress and inflammation promote renal injury via damage to molecular components of the kidney. Unfortunately, relationships between inflammation and oxidative stress are cyclical in that the inflammatory processes that exist to repair radical-mediated damage may be a source of additional free radicals, resulting in further damage to renal tissue. Oxidative stress and inflammation also have the ability to become systemic, serving to injure tissues distal to the site of original insult. This review describes select mediators in the exacerbatory relationship between oxidative stress, inflammation, and CKD. This review also discusses oxidative stress, inflammation, and CKD as they pertain to the development and progression of common CKD-associated comorbidities. Lastly, the utility of several widely accessible and cost-effective lifestyle interventions and their ability to reduce oxidative stress and inflammation are discussed and recommendations for future research are provided.
authors: Clinical Biochemistry Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia ; Human Exercise and Training Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia.
authors: Patrick S
authors: PS
authors: Tucker
authors: Clinical Biochemistry Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia ; Human Exercise and Training Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia.
authors: Aaron T
authors: AT
authors: Scanlan
authors: Clinical Biochemistry Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia ; Human Exercise and Training Laboratory, Central Queensland University, Bruce Highway Rockhampton, Building 81, Rockhampton, QLD 4703, Australia.
authors: Vincent J
authors: VJ
authors: Dalbo
mesh_terms: D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D007668:Kidney / Q000503:physiopathology*; D008019:Life Style; D018384:Oxidative Stress; D010088:Oxidoreductases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D051436:Renal Insufficiency, Chronic / Q000378:metabolism / Q000473:pathology*
chemical_list: D016207:Cytokines; D017382:Reactive Oxygen Species; D010088:Oxidoreductases