title: Toxicological and Genotoxicity Assessment of a Dihydroquercetin-Rich Dahurian Larch Tree (Larix gmelinii Rupr) Extract (Lavitol).
abstract: Safety assessment is reported of an orally ingested dihydroquercetin-rich extract (Lavitol) derived from the Dahurian larch tree, used as a food additive and as a dietary supplement ingredient. Dihydroquercetin, a potent antioxidant, is also known as taxifolin. The results of genotoxicity and toxicological tests (Comet assay, micronucleus test in human lymphocytes, chromosomal aberration test, subacute 7-day oral toxicity study, subchronic 90-day toxicology study with histopathologies, and, prenatal and postnatal developmental toxicity studies) on the extract provide further support for the safety of its consumption as a food supplement and food additive.
authors: Natural and Medicinal Products Research, AIBMR Life Sciences, Puyallup, WA, USA alex@aibmr.com.
authors: Alexander G
authors: AG
authors: Schauss
authors: Morphology Department, Central Research Laboratory, Amur State Medical University, Blagoveshchensk, Amur Oblast, Russia.
authors: Sergei S
authors: SS
authors: Tselyico
authors: Ametis, JSC, Blagoveshchensk, Amur Oblast, Russia.
authors: Victoria A
authors: VA
authors: Kuznetsova
authors: Inna Consulting Services, Northridge, CA, USA.
authors: Inna
authors: I
authors: Yegorova
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations / Q000139:chemically induced; D020552:Comet Assay; D019587:Dietary Supplements / Q000633:toxicity; D005260:Female; D005503:Food Additives / Q000633:toxicity; D006801:Humans; D028221:Larix / Q000737:chemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000633:toxicity*; D011794:Quercetin / Q000031:analogs & derivatives / Q000633:toxicity; D051381:Rats
chemical_list: D005503:Food Additives; D010936:Plant Extracts; D011794:Quercetin; C003377:taxifolin
keywords: Dahurian larch tree extract; Larix dahurica; Larix gmelinii; acute toxicity study; antioxidant; chromosomal aberration test; comet assay; developmental toxicity study; dietary supplement; dihydroquercetin; flavonoid; food additive; micronucleus test; subchronic toxicity study; taxifolin