title: Central 5-HT neurotransmission modulates weight loss following gastric bypass surgery in obese individuals.
abstract: The cerebral serotonin (5-HT) system shows distinct differences in obesity compared with the lean state. Here, it was investigated whether serotonergic neurotransmission in obesity is a stable trait or changes in association with weight loss induced by Roux-in-Y gastric bypass (RYGB) surgery. In vivo cerebral 5-HT2A receptor and 5-HT transporter binding was determined by positron emission tomography in 21 obese [four men; body mass index (BMI), 40.1 ± 4.1 kg/m(2)] and 10 lean (three men; BMI, 24.6 ± 1.5 kg/m(2)) individuals. Fourteen obese individuals were re-examined after RYGB surgery. First, it was confirmed that obese individuals have higher cerebral 5-HT2A receptor binding than lean individuals. Importantly, we found that higher presurgical 5-HT2A receptor binding predicted greater weight loss after RYGB and that the change in 5-HT2A receptor and 5-HT transporter binding correlated with weight loss after RYGB. The changes in the 5-HT neurotransmission before and after RYGB are in accordance with a model wherein the cerebral extracellular 5-HT level modulates the regulation of body weight. Our findings support that the cerebral 5-HT system contributes both to establish the obese condition and to regulate the body weight in response to RYGB.
authors: Neurobiology Research Unit, Rigshospitalet, 2100 Copenhagen, Denmark, Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark.
authors: M E
authors: ME
authors: Haahr
authors: Department of Endocrinology and.
authors: D L
authors: DL
authors: Hansen
authors: Neurobiology Research Unit, Rigshospitalet, 2100 Copenhagen, Denmark, Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark.
authors: P M
authors: PM
authors: Fisher
authors: Neurobiology Research Unit, Rigshospitalet, 2100 Copenhagen, Denmark, Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark.
authors: C
authors: C
authors: Svarer
authors: Neurobiology Research Unit, Rigshospitalet, 2100 Copenhagen, Denmark, Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark.
authors: D S
authors: DS
authors: Stenbæk
authors: Neurobiology Research Unit, Rigshospitalet, 2100 Copenhagen, Denmark, Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark.
authors: K
authors: K
authors: Madsen
authors: PET and Cyclotron Unit, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark, and.
authors: J
authors: J
authors: Madsen
authors: The NNF Center for Basic Metabolic Research, Department of Biomedical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
authors: J J
authors: JJ
authors: Holst
authors: Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark, Danish Research Centre for Magnetic Resonance, Hvidovre Hospital, 2650 Hvidovre, Denmark.
authors: W F C
authors: WF
authors: Baaré
authors: PET and Cyclotron Unit, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark, and.
authors: L
authors: L
authors: Hojgaard
authors: Steno Diabetes Center, 2820 Gentofte, Denmark.
authors: T
authors: T
authors: Almdal
authors: Neurobiology Research Unit, Rigshospitalet, 2100 Copenhagen, Denmark, Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, 2100 Copenhagen, Denmark, gmk@nru.dk.
authors: G M
authors: GM
authors: Knudsen
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D003718:Denmark; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D006801:Humans; D007650:Ketanserin / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D011485:Protein Binding / Q000187:drug effects; D011877:Radionuclide Imaging; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000493:pharmacokinetics; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D012702:Serotonin Antagonists; C071983:altanserin; D052216:Glucagon-Like Peptide 1; D007650:Ketanserin
keywords: 5-HT; 5-HT transporter; 5-HT2A receptor; bariatric surgery; positron emission tomography