title: Intraglomerular micrometastasis of squamous cell carcinoma.
abstract: Intraglomerular metastasis is a rare manifestation of disseminated malignancies. We present here a case of intraglomerular metastatic carcinoma diagnosed as an incidental finding on a kidney biopsy in a 62-year-old male presenting with acute renal failure and metastatic penile squamous cell carcinoma. A proliferative lesion composed of highly atypical epithelial cells was found within a capillary loop and adjacent urinary space of an isolated glomerulus, which was immunoreactive for markers of squamous cell carcinoma. This case is a reminder that circulating cancer cells can occasionally lodge in glomeruli and appear as micrometastasis in kidney biopsies performed for the evaluation of renal dysfunction.
authors: Department of Pathology , University of Washington Medical Center, Seattle, WA , USA.
authors: Kotaro
authors: K
authors: Sasaki
authors: Pacific Northwest University of Health Sciences , Yakima, WA 98901 , USA.
authors: Sajal
authors: S
authors: Kumar
authors: Internal Medicine , Yakima Valley Memorial Hospital , Yakima, WA 98902 , USA.
authors: Mario E
authors: ME
authors: Chenal
authors: Department of Pathology , University of Washington Medical Center, Seattle, WA , USA ; Pathology and Laboratory Medicine , VA Puget Sound Health Care System , Seattle, WA 98108 , USA.
authors: Roberto F
authors: RF
authors: Nicosia
keywords: intraglomerular metastasis; kidney biopsy; penile squamous cell carcinoma