title: Parkinsonism in spinocerebellar ataxia.
abstract: Spinocerebellar ataxia (SCA) presents heterogeneous clinical phenotypes, and parkinsonism is reported in diverse SCA subtypes. Both levodopa responsive Parkinson disease (PD) like phenotype and atypical parkinsonism have been described especially in SCA2, SCA3, and SCA17 with geographic differences in prevalence. SCA2 is the most frequently reported subtype of SCA related to parkinsonism worldwide. Parkinsonism in SCA2 has unique genetic characteristics, such as low number of expansions and interrupted structures, which may explain the sporadic cases with low penetrance. Parkinsonism in SCA17 is more remarkable in Asian populations especially in Korea. In addition, an unclear cutoff of the pathologic range is the key issue in SCA17 related parkinsonism. SCA3 is more common in western cohorts. SCA6 and SCA8 have also been reported with a PD-like phenotype. Herein, we reviewed the epidemiologic, clinical, genetic, and pathologic features of parkinsonism in SCAs.
authors: Departments of Neurology and Movement Disorder Center, College of Medicine, Seoul National University Hospital, Seoul National University, Seoul 110-744, Republic of Korea.
authors: Hyeyoung
authors: H
authors: Park
authors: Departments of Neurology and Movement Disorder Center, College of Medicine, Seoul National University Hospital, Seoul National University, Seoul 110-744, Republic of Korea.
authors: Han-Joon
authors: HJ
authors: Kim
authors: Departments of Neurology and Movement Disorder Center, College of Medicine, Seoul National University Hospital, Seoul National University, Seoul 110-744, Republic of Korea.
authors: Beom S
authors: BS
authors: Jeon
mesh_terms: D006801:Humans; D020734:Parkinsonian Disorders / Q000145:classification / Q000150:complications / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D020754:Spinocerebellar Ataxias / Q000145:classification / Q000150:complications / Q000453:epidemiology / Q000235:genetics / Q000473:pathology