title: [The informative laboratory biomarkers for detection of negative impact of vibration on organism of workers].
abstract: The analysis was carried out concerning new characteristics of diagnostic informativeness of particular biochemical, immunologic, cytochemical and hematologic indicators under impact of vibration on human organism. It is established that high diagnostic informativeness is typical for indicators of oxidation metabolism (alpha-superoxide dismutase, myeloperoxidase in neutrophils, alpha-tokopherol), humoral immunity (IgA, IgG), hematologic indicators (corpuscular volume, peroxide hemolysis of erythrocytes, thrombocytes aggregation velocity) and level of creatinine in urine reflecting damages of muscular tissue. The levels of biomarkers mentioned above begin to alter in healthy workers and in individuals under suspicion of vibration disease. These indicators are characterized by high diagnostic sensitivity and pathognomonicity and can be recommended for early diagnostic of vibration disease.
authors: L I
authors: LI
authors: Antoshina
authors: N A
authors: NA
authors: Pavlovskaia
authors: I V
authors: IV
authors: Iatsyna
mesh_terms: D015415:Biomarkers / Q000097:blood*; D003404:Creatinine / Q000652:urine; D004912:Erythrocytes; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D009784:Occupational Diseases / Q000097:blood* / Q000652:urine*; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D014732:Vibration / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D003404:Creatinine; D009195:Peroxidase; D013482:Superoxide Dismutase