title: Long-term subarachnoid haemorrhage survivors still die due to cerebrovascular causes.
abstract: OBJECTIVE
  Subarachnoid haemorrhage (SAH) is associated with sympathetic nervous activation and inflammation. SAH could therefore theoretically be a risk factor for development of cardiovascular disease. The aim of this study was to investigate whether long-term (≥1 year) SAH survivors had an increased risk of death due to cardiovascular causes.
  
  
  METHODS
  SAH patients ≥18 years treated at Umeå University Hospital between 1986 and 2006 were eligible for inclusion. Deceased patients were identified in the Swedish population register. Death certificates from long-term SAH survivors and causes of death in the general population were obtained from the National Board of Health and Welfare, Sweden. The prevalence of comorbidities at the time of SAH was compared with the distribution of cardiovascular risk factors in the northern Sweden MONICA (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease) health survey. Analyses were stratified for age and sex.
  
  
  RESULTS
  In the SAH patients, the median year of SAH was 1992 and the median year of death was 2001. The MONICA survey in 1994 and the distribution of deaths in the general population in 2001 were used for comparison. Long-term SAH survivors had, compared to the general population, a significantly increased risk for death due to cerebrovascular disease (P < 0.0001), but not for death due to cardiovascular disease. Hypertension was more common in SAH patients compared to survey participants (P < 0.01).
  
  
  CONCLUSIONS
  Cerebrovascular causes of death were significantly more common in long-term survivors after SAH compared to the general population.
authors: Department of Surgical and Perioperative Sciences, Anaesthesiology and Intensive Care, Umeå University, Umeå, Sweden.
authors: C
authors: C
authors: Lindgren
authors: Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.
authors: S
authors: S
authors: Söderberg
authors: Department of Pharmacology and Clinical Neuroscience, Neurosurgery, Umeå University, Umeå, Sweden.
authors: L-O D
authors: LO
authors: Koskinen
authors: Department of Surgical and Perioperative Sciences, Anaesthesiology and Intensive Care, Umeå University, Umeå, Sweden.
authors: M
authors: M
authors: Hultin
authors: Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.
authors: L
authors: L
authors: Edvardsson
authors: Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
authors: S
authors: S
authors: Naredi
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D002561:Cerebrovascular Disorders / Q000401:mortality*; D015897:Comorbidity; D003644:Death Certificates; D005260:Female; D006306:Health Surveys; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D012737:Sex Factors; D013345:Subarachnoid Hemorrhage / Q000401:mortality*; D017741:Survivors; D013548:Sweden / Q000453:epidemiology
keywords: cardiovascular disease; cerebrovascular disease; epidemiology; subarachnoid haemorrhage