title: Acute phase proteins in racehorses with inflammatory airway disease.
abstract: BACKGROUND
  Systemic inflammation is observed in horses with heaves and could also be present in horses with a lesser degree of pulmonary inflammation.
  
  
  OBJECTIVE
  It was hypothesized that racehorses with inflammatory airway disease (IAD) have increased concentration of circulating acute phase proteins. The objective of this study was to compare serum acute phase proteins of racehorses with and without lower airway inflammation.
  
  
  METHODS
  Serum from 21 client-owned Standardbred racehorses with exercise intolerance and lower airway inflammation and serum from 10 client-owned Standardbred racehorses with exercise intolerance without lower airway inflammation.
  
  
  METHODS
  In a case-control study, serum samples from previously characterized horses presented for exercise intolerance with or without lower airway inflammation based on bronchoalveolar lavage fluid cytology were analyzed for serum amyloid A protein (SAA), C-reactive protein (CRP), and haptoglobin using commercial ELISAs.
  
  
  RESULTS
  There was no significant differences between groups for SAA (non-IAD versus IAD, median (range): 3.47 (0.06-34.94) versus 6.33 (0.06-80) μg/mL, P = .49), CRP (10.87 (2.05-29.03) versus 4.63 (0.02-31.81) μg/mL, P = .23) or haptoglobin (900.36 (607.99-2018.84) versus 749.54 (530.81-1076.95) μg/mL, P = .09).
  
  
  CONCLUSIONS
  In this population of poorly performing racehorses in training, serum SAA, CRP, and haptoglobin were not helpful in distinguishing between horses with IAD from horses with exercise intolerance from other causes.
authors: Faculty of Veterinary Medicine, Clinical Sciences Department, Université de Montréal, Saint-Hyacinthe, QC, Canada.
authors: M
authors: M
authors: Leclere
authors: Faculty of Veterinary Medicine, Clinical Sciences Department, Université de Montréal, Saint-Hyacinthe, QC, Canada.
authors: A
authors: A
authors: Lavoie-Lamoureux
authors: Faculty of Veterinary Medicine, Clinical Sciences Department, Université de Montréal, Saint-Hyacinthe, QC, Canada.
authors: J-P
authors: JP
authors: Lavoie
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006734:Horse Diseases / Q000097:blood*; D006736:Horses; D007249:Inflammation / Q000097:blood / Q000662:veterinary*; D008297:Male; D012140:Respiratory Tract Diseases / Q000097:blood / Q000662:veterinary*; D000685:Serum Amyloid A Protein / Q000032:analysis
chemical_list: D000209:Acute-Phase Proteins; D006242:Haptoglobins; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein
keywords: C-reactive protein; Haptoglobin; Inflammatory airway disease; Serum amyloid A