title: Molecular basis of oxidative stress in gouty arthropathy.
abstract: Gout is a disorder of urate metabolism in which persistent high urate levels in the extracellular fluids result in the deposition of monosodium urate (MSU) crystal in joints and periarticular tissues. In recent years, this disease represents an increasingly common health problem, so the pace of investigation in the field has accelerated tremendously. New research advances in the pathogenesis of hyperuricemia and in the understanding of how MSU crystals induce an acute gouty attack have been focused in this review on the processes of inflammation and involvement of the innate immune response; in addition, we discuss new knowledge about the role of the reactive oxygen species in establishing oxidative stress in MSU crystal-induced arthritis.
authors: Molecular Synovioanalysis and Musculoskeletal Ultrasound Laboratories, Instituto Nacional de Rehabilitación, Calzada Mexico-Xochimilco 289, Col. Arenal de Guadalupe, Delegación Tlalpan, 14389, Mexico, D.F, Mexico.|Molecular Microbiology Laboratory, Department of Microbiology, Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional (IPN), Prolongación de Carpio y Plan de Ayala S/N, Col. Casco de Santo Tomás, Delegación Miguel Hidalgo, 11340, Mexico, D.F, Mexico.
authors: Yessica
authors: Y
authors: Zamudio-Cuevas
authors: Molecular Synovioanalysis and Musculoskeletal Ultrasound Laboratories, Instituto Nacional de Rehabilitación, Calzada Mexico-Xochimilco 289, Col. Arenal de Guadalupe, Delegación Tlalpan, 14389, Mexico, D.F, Mexico.
authors: Cristina
authors: C
authors: Hernández-Díaz
authors: Molecular Synovioanalysis and Musculoskeletal Ultrasound Laboratories, Instituto Nacional de Rehabilitación, Calzada Mexico-Xochimilco 289, Col. Arenal de Guadalupe, Delegación Tlalpan, 14389, Mexico, D.F, Mexico.
authors: Carlos
authors: C
authors: Pineda
authors: Rheumatology Division, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA.
authors: Anthony M
authors: AM
authors: Reginato
authors: Molecular Microbiology Laboratory, Department of Microbiology, Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional (IPN), Prolongación de Carpio y Plan de Ayala S/N, Col. Casco de Santo Tomás, Delegación Miguel Hidalgo, 11340, Mexico, D.F, Mexico.
authors: Jorge Francisco
authors: JF
authors: Cerna-Cortés
authors: Molecular Synovioanalysis and Musculoskeletal Ultrasound Laboratories, Instituto Nacional de Rehabilitación, Calzada Mexico-Xochimilco 289, Col. Arenal de Guadalupe, Delegación Tlalpan, 14389, Mexico, D.F, Mexico.
authors: Lucio
authors: L
authors: Ventura-Ríos
authors: Molecular Synovioanalysis and Musculoskeletal Ultrasound Laboratories, Instituto Nacional de Rehabilitación, Calzada Mexico-Xochimilco 289, Col. Arenal de Guadalupe, Delegación Tlalpan, 14389, Mexico, D.F, Mexico. allorey@yahoo.com.
authors: Alberto
authors: A
authors: López-Reyes
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015210:Arthritis, Gouty / Q000378:metabolism*; D003460:Crystallization; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D033461:Hyperuricemia / Q000503:physiopathology; D007113:Immunity, Innate; D007249:Inflammation; D007596:Joints / Q000276:immunology; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D014527:Uric Acid / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016207:Cytokines; D017382:Reactive Oxygen Species; D014527:Uric Acid
keywords: Gouty arthropathy; Monosodium urate crystals; Oxidative stress; Synoviocytes