title: Oxidative stress to the cornea, changes in corneal optical properties, and advances in treatment of corneal oxidative injuries.
abstract: Oxidative stress is involved in many ocular diseases and injuries. The imbalance between oxidants and antioxidants in favour of oxidants (oxidative stress) leads to the damage and may be highly involved in ocular aging processes. The anterior eye segment and mainly the cornea are directly exposed to noxae of external environment, such as air pollution, radiation, cigarette smoke, vapors or gases from household cleaning products, chemical burns from splashes of industrial chemicals, and danger from potential oxidative damage evoked by them. Oxidative stress may initiate or develop ocular injury resulting in decreased visual acuity or even vision loss. The role of oxidative stress in the pathogenesis of ocular diseases with particular attention to oxidative stress in the cornea and changes in corneal optical properties are discussed. Advances in the treatment of corneal oxidative injuries or diseases are shown.
authors: Laboratory of Eye Histochemistry and Pharmacology, Department of Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague 4, Czech Republic.
authors: Cestmir
authors: C
authors: Cejka
authors: Laboratory of Eye Histochemistry and Pharmacology, Department of Neuroscience, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague 4, Czech Republic.
authors: Jitka
authors: J
authors: Cejkova
mesh_terms: D000468:Alkalies / Q000633:toxicity; D000818:Animals; D003315:Cornea / Q000187:drug effects / Q000528:radiation effects; D065306:Corneal Injuries / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D017382:Reactive Oxygen Species / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D000468:Alkalies; D009883:Ophthalmic Solutions; D017382:Reactive Oxygen Species