title: A growth-rate composition formula for the growth of E.coli on co-utilized carbon substrates.
abstract: When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system responds to the total carbon-uptake flux when substrates are co-utilized and derive a mathematical formula that accurately predicts the resulting growth rate, based only on the growth rates on individual substrates.
authors: Department of Physics, University of California at San Diego, La Jolla, CA, USA TBB Group, Department of Biology, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
authors: Rutger
authors: R
authors: Hermsen
authors: Department of Physics, University of California at San Diego, La Jolla, CA, USA.
authors: Hiroyuki
authors: H
authors: Okano
authors: Department of Physics, University of California at San Diego, La Jolla, CA, USA.
authors: Conghui
authors: C
authors: You
authors: Department of Physics, University of California at San Diego, La Jolla, CA, USA.
authors: Nicole
authors: N
authors: Werner
authors: Department of Physics, University of California at San Diego, La Jolla, CA, USA hwa@ucsd.edu.
authors: Terence
authors: T
authors: Hwa
mesh_terms: D000465:Algorithms; D002244:Carbon / Q000378:metabolism*; D057465:Catabolite Repression; D003470:Culture Media / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D002373:Cyclic AMP Receptor Protein / Q000378:metabolism; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000378:metabolism; D025461:Feedback, Physiological; D017930:Genes, Reporter
chemical_list: D003470:Culture Media; D002373:Cyclic AMP Receptor Protein; D029968:Escherichia coli Proteins; C481662:crp protein, E coli; D002244:Carbon; D000242:Cyclic AMP
keywords: bacterial growth; catabolite repression; metabolic coordination; mixed carbon‐substrate growth