title: Extracorporeal Treatment in Severe Hypertriglyceridemia-Induced Pancreatitis.
abstract: Plasmapheresis is a well-accepted treatment option in severe hypertriglyceridemia-induced pancreatitis (HTGP). The rationale behind this approach is the depletion of triglycerides and the reduction of inflammatory cytokines. The time span between onset of clinical symptoms and start of plasmapheresis might have an important impact on mortality. Hyperviscosity of patients' plasma represents another special challenge for the applied separation technology. The procedures can be performed either by centrifugal device (CFD) or membrane based (MBS) units. The present study reports the outcome of 10 patients suffering from HTG. The expected mortality of the collective was 25%. Plasmapheresis was started after an average 16.3 h (SD ± 6.7 h) after onset of symptoms. No mortality occurred. Apheresis was statistically equally effective with both devices. A median of 3 sessions reduced the TG level to normal and correlated with patients' improvement. During follow up, three patients developed a pancreatic pseudocyst requiring surgical intervention without further complication.
authors: Internal Medical Clinic I, Centre of Extracorporeal Therapy and Autoimmunity (CETA), University of Bonn, Bonn, Germany.
authors: Heike
authors: H
authors: Zeitler
authors: Internal Medical Clinic I, Centre of Extracorporeal Therapy and Autoimmunity (CETA), University of Bonn, Bonn, Germany.
authors: Zeynep
authors: Z
authors: Balta
authors: Internal Medical Clinic I, Centre of Extracorporeal Therapy and Autoimmunity (CETA), University of Bonn, Bonn, Germany.
authors: Burkhard
authors: B
authors: Klein
authors: Internal Medical Clinic I, Centre of Extracorporeal Therapy and Autoimmunity (CETA), University of Bonn, Bonn, Germany.
authors: Christian P
authors: CP
authors: Strassburg
mesh_terms: D000328:Adult; D000368:Aged; D057186:Comparative Effectiveness Research; D016207:Cytokines / Q000097:blood*; D004867:Equipment Design; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010195:Pancreatitis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000628:therapy; D010956:Plasmapheresis / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis; D061665:Time-to-Treatment / Q000706:statistics & numerical data; D014280:Triglycerides / Q000097:blood*
chemical_list: D016207:Cytokines; D014280:Triglycerides
keywords: Hypertriglyceridemia; Pancreatitis; Plasmapheresis