title: Good practices for building dynamical models in systems biology.
abstract: Dynamic models can offer deep understanding of information processing mechanisms in physiology, cell signaling, and biological regulation when they are appropriately detailed. Here, we describe some of the key aspects of the model-building process, including proper parameterization and error analysis, as well as common mistakes, such as model-tweaking and oversimplification, which can decrease the value of the models.
authors: Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
authors: Evren U
authors: EU
authors: Azeloglu
authors: Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ravi.iyengar@mssm.edu.
authors: Ravi
authors: R
authors: Iyengar
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods*