title: Prospects for using self-assembled nucleic acid structures.
abstract: According to the central dogma in molecular biology, nucleic acids are assigned with key functions on storing and executing genetic information in any living cell. However, features of nucleic acids are not limited only with properties providing template-dependent biosynthetic processes. Studies of DNA and RNA unveiled unique features of these polymers able to make various self-assembled three-dimensional structures that, among other things, use the complementarity principle. Here, we review various self-assembled nucleic acid structures as well as application of DNA and RNA to develop nanomaterials, molecular automata, and nanodevices. It can be expected that in the near future results of these developments will allow designing novel next-generation diagnostic systems and medicinal drugs.
authors: Research Division, Hospital for Special Surgery, New York, NY 10021, USA. rudchenkom@hss.edu.
authors: M N
authors: MN
authors: Rudchenko
authors: A A
authors: AA
authors: Zamyatnin
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D021881:DNA, Catalytic / Q000737:chemistry; D015316:Genetic Therapy; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D016337:RNA, Catalytic / Q000737:chemistry
chemical_list: D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D016337:RNA, Catalytic; D012313:RNA; D004247:DNA