title: Molecular methods for somatic mutation testing in lung adenocarcinoma: EGFR and beyond.
abstract: Somatic mutational profiling in cancer has revolutionized the practice of clinical oncology. The discovery of driver mutations in non-small cell lung cancer (NSCLC) is an example of this. Molecular testing of lung adenocarcinoma is now considered standard of care and part of the diagnostic algorithm. This article provides an overview of the workflow of molecular testing in a clinical diagnostic laboratory discussing in particular novel assays that are currently in use for somatic mutation detection in NSCLC focussing on epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK), ROS1 and RET rearrangements.
authors: 1 Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Place, Victoria 3002, Australia ; 2 Department of Pathology, University of Melbourne, Victoria 3002, Australia.
authors: Christine
authors: C
authors: Khoo
authors: 1 Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Place, Victoria 3002, Australia ; 2 Department of Pathology, University of Melbourne, Victoria 3002, Australia.
authors: Toni-Maree
authors: TM
authors: Rogers
authors: 1 Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Place, Victoria 3002, Australia ; 2 Department of Pathology, University of Melbourne, Victoria 3002, Australia.
authors: Andrew
authors: A
authors: Fellowes
authors: 1 Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Place, Victoria 3002, Australia ; 2 Department of Pathology, University of Melbourne, Victoria 3002, Australia.
authors: Anthony
authors: A
authors: Bell
authors: 1 Department of Pathology, Peter MacCallum Cancer Centre, St Andrews Place, Victoria 3002, Australia ; 2 Department of Pathology, University of Melbourne, Victoria 3002, Australia.
authors: Stephen
authors: S
authors: Fox
keywords: Epidermal growth factor receptor (EGFR); RET; ROS1; anaplastic lymphoma kinase (ALK)