title: Quantitative methods for reconstructing tissue biomechanical properties in optical coherence elastography: a comparison study.
abstract: We present a systematic analysis of the accuracy of five different methods for extracting the biomechanical properties of soft samples using optical coherence elastography (OCE). OCE is an emerging noninvasive technique, which allows assessment of biomechanical properties of tissues with micrometer spatial resolution. However, in order to accurately extract biomechanical properties from OCE measurements, application of a proper mechanical model is required. In this study, we utilize tissue-mimicking phantoms with controlled elastic properties and investigate the feasibilities of four available methods for reconstructing elasticity (Young's modulus) based on OCE measurements of an air-pulse induced elastic wave. The approaches are based on the shear wave equation (SWE), the surface wave equation (SuWE), Rayleigh-Lamb frequency equation (RLFE), and finite element method (FEM), Elasticity values were compared with uniaxial mechanical testing. The results show that the RLFE and the FEM are more robust in quantitatively assessing elasticity than the other simplified models. This study provides a foundation and reference for reconstructing the biomechanical properties of tissues from OCE data, which is important for the further development of noninvasive elastography methods.
authors: Department of Biomedical Engineering, Cullen College of Engineering, University of Houston, 2026 SERC, Houston, TX 77204, USA.
authors: Zhaolong
authors: Z
authors: Han
authors: Jiasong
authors: J
authors: Li
authors: Manmohan
authors: M
authors: Singh
authors: Chen
authors: C
authors: Wu
authors: Chih-hao
authors: CH
authors: Liu
authors: Shang
authors: S
authors: Wang
authors: Rita
authors: R
authors: Idugboe
authors: Raksha
authors: R
authors: Raghunathan
authors: Narendran
authors: N
authors: Sudheendran
authors: Salavat R
authors: SR
authors: Aglyamov
authors: Michael D
authors: MD
authors: Twa
authors: Kirill V
authors: KV
authors: Larin
mesh_terms: D000465:Algorithms; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D019047:Phantoms, Imaging; D041623:Tomography, Optical Coherence / Q000379:methods*