title: The effects of periodontal therapy on serum and salivary leptin levels in chronic periodontitis patients with normal body mass index.
abstract: CONCLUSIONS
  Leptin concentrations are altered in favour of pro health after periodontal therapy.
  
  
  BACKGROUND
  Leptin, a non-glycosylated peptide hormone, not only maintains fat stores, but is also an integral part of host defense repertoire. Leptin levels have been found to be altered in an array of inflammatory diseases including chronic periodontitis (CP), but the role of non-surgical periodontal therapy (NSPT) in altering the leptin concentrations in saliva and serum of CP patients is yet to be ascertained. The aim of the present study is to quantify leptin levels in CP patients having normal body mass index (BMI) pre-therapy as compared to periodontally healthy controls and to address whether successful NSPT alters leptin concentration in serum and saliva.
  
  
  METHODS
  Twenty-two saliva (modified draining method) and serum samples (by venipuncture) were collected from CP patients with normal BMI (n = 22), before and at 4 and 12 weeks after completion of NSPT, and periodontally healthy, age- and gender-matched controls (n = 22). Leptin levels were estimated using enzyme linked immunosorbent assay kits.
  
  
  RESULTS
  At baseline, CP patients had significantly different periodontal clinical parameters and the leptin concentrations in saliva of CP patients were found to be significantly lower than periodontally healthy volunteers (4710.10 ± 1133.21 vs 8721.10 ± 1019.58 pg/ml) (p < 0.05), whereas in serum the leptin concentrations were significantly higher than healthy controls (10749 ± 2062.24 vs 8085.00 ± 2859.68 pg/ml). Significant improvement in periodontal parameters, serum and salivary leptin levels were observed in CP patients at 4 and 12 weeks post-therapy (p < 0.01).
  
  
  CONCLUSIONS
  Altered concentrations of leptin in serum and saliva are observed in CP patients which can be restored in favor of health after periodontal therapy.
authors: Department of Periodontology, Faculty of Dental Sciences, King George's Medical University , Lucknow, Uttar Pradesh , India.
authors: Parth
authors: P
authors: Purwar
authors: Mohammed Akhlaq
authors: MA
authors: Khan
authors: Abhishek
authors: A
authors: Gupta
authors: Abbas Ali
authors: AA
authors: Mahdi
authors: Shivani
authors: S
authors: Pandey
authors: Babita
authors: B
authors: Singh
authors: Jaya
authors: J
authors: Dixit
authors: Priya
authors: P
authors: Rai
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000097:blood / Q000628:therapy*; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007182:Income; D020738:Leptin / Q000032:analysis / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene / Q000193:education; D017622:Periodontal Attachment Loss / Q000097:blood / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000628:therapy; D016745:Root Planing / Q000379:methods; D012463:Saliva / Q000737:chemistry*; D012923:Social Class; D014099:Toothbrushing
chemical_list: D020738:Leptin
keywords: Cardiovascular disease; leptin; non-surgical periodontal therapy; periodontitis; saliva; serum