title: Recurrence after radiotherapy for gastric mucosa-associated lymphoid tissue (MALT) lymphoma with trisomy 18.
abstract: A 36-year-old Japanese woman presented with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the stomach. The gastric lesions only partially improved after eradication therapy for Helicobacter pylori. A fluorescence in situ hybridization analysis revealed no fusion genes of API2-MALT1, although trisomy of chromosome 18 was identified. Radiation therapy was initiated to treat the gastric lymphoma lesions, resulting in complete remission. However, MALT lymphoma recurred in the stomach 16 months later. This case indicates that intensive follow-up is required for MALT lymphoma associated with chromosomal aberrations in order to detect early relapse.
authors: Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.
authors: Hisashi
authors: H
authors: Ishikawa
authors: Masaya
authors: M
authors: Iwamuro
authors: Hiroyuki
authors: H
authors: Okada
authors: Keisuke
authors: K
authors: Hori
authors: Masahide
authors: M
authors: Kita
authors: Seiji
authors: S
authors: Kawano
authors: Yoshiro
authors: Y
authors: Kawahara
authors: Takehiro
authors: T
authors: Tanaka
authors: Eisei
authors: E
authors: Kondo
authors: Tadashi
authors: T
authors: Yoshino
authors: Kazuhide
authors: K
authors: Yamamoto
mesh_terms: D000328:Adult; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D016481:Helicobacter Infections / Q000188:drug therapy / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008221:Lymphoid Tissue / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000382:microbiology / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D013274:Stomach Neoplasms / Q000382:microbiology / Q000532:radiotherapy*; D014314:Trisomy / Q000175:diagnosis*; D000073842:Trisomy 18 Syndrome