title: Post-transplant liver function score as an early surrogate marker of long-term outcome.
abstract: BACKGROUND
  Currently, there is no universally accepted method to evaluate liver function post-orthotopic liver transplant (OLTx) and there are no early surrogate function markers to assess the impact of perioperative interventions in trial settings.
  
  
  METHODS
  In total, 495 patients were included in the study. On multivariate analysis, PTLF score, defined as normal (score <4) or dysfunctional (score ≥ 4), was the only significant variable for determining significant complications (P=0.014) and graft survival (P=002) during the perioperative period.
  
  
  RESULTS
  In total, 495 patients were included in the study. On multivariate analysis, PTLF score, defined as normal (score <4) or dysfunctional (score ≥ 4), was the only significant variable for determining significant complications (P=0.014) and graft survival (P=002) during the perioperative period.
  
  
  CONCLUSIONS
  PTLF score shows promise as an early surrogate marker of post-orthotopic liver transplantation mortality and morbidity by providing results within the first 7 days post-transplantation. PTLF score can potentially be used as a tool to assess the impact of perioperative interventions by predicting long-term outcomes early in the clinical course of transplant patients.
authors: Department of Surgery, King Saud University, Riyadh, Saudi Arabia.
authors: Mazen
authors: M
authors: Hassanain
authors: Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, QC, Canada.
authors: Eve
authors: E
authors: Simoneau
authors: Department of Surgery, King Saud University, Riyadh, Saudi Arabia.
authors: Ahmad
authors: A
authors: Madkhali
authors: Department of Surgery, King Saud University, Riyadh, Saudi Arabia.
authors: Nouf
authors: N
authors: Al-Saati
authors: Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia.
authors: Murad
authors: M
authors: Aljiffry
authors: Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, QC, Canada.
authors: Jean
authors: J
authors: Tchervenkov
authors: Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, QC, Canada.
authors: Jeffrey
authors: J
authors: Barkun
authors: Division of Hepato-Pancreatobiliary and Transplant Surgery, Department of Surgery, McGill University, Montreal, QC, Canada.
authors: Peter
authors: P
authors: Metrakos
mesh_terms: D000328:Adult; D015415:Biomarkers; D005260:Female; D006084:Graft Rejection / Q000503:physiopathology*; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008111:Liver Function Tests; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers