title: The combination of decoy receptor 3 and soluble triggering receptor expressed on myeloid cells-1 for the diagnosis of nosocomial bacterial meningitis.
abstract: BACKGROUND
  Early diagnosis and appropriate antibiotic treatment can significantly reduce mortality of nosocomial bacterial meningitis. However, it is a challenge for clinicians to make an accurate and rapid diagnosis of bacterial meningitis. This study aimed at determining whether combined biomarkers can provide a useful tool for the diagnosis of bacterial meningitis.
  
  
  METHODS
  A retrospective study was carried out. Cerebrospinal fluid (CSF) levels of decoy receptor 3 (DcR3) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) were detected by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The patients with bacterial meningitis had significantly elevated levels of the above mentioned biomarkers. The two biomarkers were all risk factors with bacterial meningitis. The biomarkers were constructed into a "bioscore". The discriminative performance of the bioscore was better than that of each biomarker, with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.842 (95% confidence intervals (CI) 0.770-0.914; p< 0.001).
  
  
  CONCLUSIONS
  Combined measurement of CSF DcR3 and sTREM-1 concentrations improved the prediction of nosocomial bacterial meningitis. The combined strategy is of interest and the validation of that improvement needs further studies.
authors: Yong-Juan
authors: YJ
authors: Liu
authors: Li-Hua
authors: LH
authors: Shao
authors: Jian
authors: J
authors: Zhang
authors: Shan-Ji
authors: SJ
authors: Fu
authors: Gang
authors: G
authors: Wang
authors: Feng-Zhe
authors: FZ
authors: Chen
authors: Feng
authors: F
authors: Zheng
authors: Rui-Ping
authors: RP
authors: Ma
authors: Hai-Hong
authors: HH
authors: Liu
authors: Xiao-Meng
authors: XM
authors: Dong
authors: Li-Xian
authors: LX
authors: Ma
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003428:Cross Infection / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008562:Membrane Glycoproteins / Q000134:cerebrospinal fluid*; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D008875:Middle Aged; D022423:Myeloid Cells / Q000378:metabolism*; D012372:ROC Curve; D011971:Receptors, Immunologic; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000134:cerebrospinal fluid*; D012189:Retrospective Studies; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D053323:Receptors, Tumor Necrosis Factor, Member 6b; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1