title: Flaxseed mitigates brain mass loss, improving motor hyperactivity and spatial memory, in a rodent model of neonatal hypoxic-ischemic encephalopathy.
abstract: Neonatal hypoxic-ischemic (HI) encephalopathy is a major cause of perinatal morbimortality. There is growing evidence that n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), attenuate brain injury. This study aimed to investigate the possible neuroprotective effect of maternal intake of flaxseed, rich in DHA׳s precursor α-linolenic acid, in the young male offspring subjected to perinatal HI. Wistar rats were divided in six groups, according to maternal diet and offspring treatment at day 7: Control HI (CHI) and Flaxseed HI (FHI); Control Sham and Flaxseed Sham; Control Control and Flaxseed Control. Flaxseed diet increased offspring׳s hippocampal DHA content and lowered depressive behavior. CHI pups presented brain mass loss, motor hyperactivity and poor spatial memory, which were improved in FHI rats. Maternal flaxseed intake may prevent depressive symptoms in the offspring and promote neuroprotective effects, in the context of perinatal HI, improving brain injury and its cognitive and behavioral impairments.
authors: Laboratório de Bioquímica Nutricional, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro. Rio de Janeiro , RJ, Brazil.
authors: Daniela de Barros
authors: Dde B
authors: Mucci
authors: Laboratório de Bioquímica Nutricional, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro. Rio de Janeiro , RJ, Brazil.
authors: Flávia Spreafico
authors: FS
authors: Fernandes
authors: Laboratório de Farmacologia da Neuroplasticidade e do Comportamento, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brazil.
authors: Amanda Dos Santos
authors: Ados S
authors: Souza
authors: Laboratório de Bioquímica Nutricional, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro. Rio de Janeiro , RJ, Brazil.
authors: Fátima Lúcia de Carvalho
authors: FL
authors: Sardinha
authors: Laboratório de Bioquímica Nutricional, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro. Rio de Janeiro , RJ, Brazil.
authors: Márcia
authors: M
authors: Soares-Mota
authors: Laboratório de Bioquímica Nutricional, Instituto de Nutrição Josué de Castro, Universidade Federal do Rio de Janeiro. Rio de Janeiro , RJ, Brazil. Electronic address: tcarmo@editema.com.br.
authors: Maria das Graças
authors: Md
authors: Tavares do Carmo
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001930:Brain Injuries / Q000503:physiopathology / Q000517:prevention & control; D004281:Docosahexaenoic Acids / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D019597:Flax / Q000737:chemistry*; D006948:Hyperkinesis / Q000503:physiopathology / Q000517:prevention & control*; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry; D065852:Spatial Memory / Q000187:drug effects*; D013997:Time Factors; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids
keywords: Depression; Essential fatty acids; Flaxseed; Memory; Neonatal hypoxia-ischemia