title: A histomorphometric study of the effect of doxycycline and erythromycin on bone formation in dental alveolar socket of rat.
abstract: BACKGROUND
  The aim of the present study was to evaluate whether subantimicrobial doses of doxycycline (DOX) and erythromycin (EM) used for the treatment of peri-implant osteolysis due to their anti-osteoclastogenesis can interfere with the osseous wound healing process in rat alveolar socket.
  
  
  METHODS
  Forty-five male Wistar rats had their first maxillary right molar extracted and were divided into three groups. DOX and EM at the doses of 5 mg/kg/day orally (p.o.) and 2 mg/kg/day intraperitoneally (i.p.) were administered respectively to two separate groups for 7 days after operation. In the control group the animals received normal saline (5 ml/kg). Five rats were sacrificed at 7, 14 and 21 days post-extraction in each study group. A histomorphometric analysis was used to evaluate new bone formation inside the alveolar socket. Significant level was set at 0.05.
  
  
  RESULTS
  The findings showed that the percentage of new bone formation (NBF) enhanced significantly on days 7 and 14. There was no significant difference in the NBF between DOX and EM groups.
  
  
  CONCLUSIONS
  Short-term treatment with both DOX and EM enhanced new bone formation without any advances in favor of each drug.
authors: Department of Periodontology, Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mohammad
authors: M
authors: Shahabooei
authors: Department of Oral and Maxillofacial Pathology, Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Sayed Mohammad
authors: SM
authors: Razavi
authors: Department of Pharmacology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mohsen
authors: M
authors: Minaiyan
authors: Department of Periodontology, Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Reza
authors: R
authors: Birang
authors: Department of Periodontology, Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Parichehr
authors: P
authors: Behfarnia
authors: Department of Periodontology, Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Jaber
authors: J
authors: Yaghini
authors: Department of Periodontology, Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Narges
authors: N
authors: Naghsh
authors: Department of Oral and Maxillofacial Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Parichehr
authors: P
authors: Ghalayani
authors: Department of Oral and Maxillofacial Medicine, School of Dentistry, Qom University of Medical Sciences, Qom, Iran.
authors: Samira
authors: S
authors: Hajisadeghi
keywords: Doxycycline; erythromycin; histomorphometry; osteogenesis; rats