title: Vulvar Myxoid Liposarcoma and Well Differentiated Liposarcoma With Molecular Cytogenetic Confirmation: Case Reports With Review of Malignant Lipomatous Tumors of the Vulva.
abstract: Malignant lipomatous tumors of the vulva are uncommon. We present 2 cases of liposarcoma arising in the vulva: a myxoid liposarcoma harboring DDIT3 and FUS rearrangements and a well differentiated liposarcoma/atypical lipomatous tumor harboring MDM2 amplification detected by fluorescence in situ hybridization. Both cases are the first liposarcomas of this site to be confirmed by molecular cytogenetic analysis. We also review the literature's cases of liposarcoma to further examine the clinicopathologic features of these tumors.
authors: Department of Laboratory Medicine and Pathology (J.K.S.), Mayo Clinic, Rochester, Minnesota Department of Pathology, Memorial Sloan Kettering Cancer Center (J.K.S., A.J.L., L.W., M.R.H.), New York, New York.
authors: John Kenneth
authors: JK
authors: Schoolmeester
authors: Aaron J
authors: AJ
authors: Leifer
authors: Lu
authors: L
authors: Wang
authors: Meera R
authors: MR
authors: Hameed
mesh_terms: D000328:Adult; D000368:Aged; D003582:Cytogenetics; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008067:Lipoma / Q000235:genetics / Q000473:pathology*; D018208:Liposarcoma, Myxoid / Q000235:genetics / Q000473:pathology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics; D034702:RNA-Binding Protein FUS / Q000235:genetics; D051742:Transcription Factor CHOP / Q000235:genetics; D014844:Vulva / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000235:genetics / Q000473:pathology*
chemical_list: C497249:DDIT3 protein, human; C000599550:FUS protein, human; D034702:RNA-Binding Protein FUS; D051742:Transcription Factor CHOP; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2