title: Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer.
abstract: Post-transcriptional regulation of RNA is an important mechanism for activating and resolving cellular stress responses. Poly(ADP-ribose) polymerase-13 (PARP13), also known as ZC3HAV1 and zinc-finger antiviral protein (ZAP), is an RNA-binding protein that regulates the stability and translation of specific mRNAs, and modulates the miRNA silencing pathway to globally affect miRNA targets. These functions of PARP13 are important components of the cellular response to stress. In addition, the ability of PARP13 to restrict oncogenic viruses and to repress the prosurvival cytokine receptor tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptor 4 (TRAILR4) suggests that it can be protective against malignant transformation and cancer development. The relevance of PARP13 to human health and disease make it a promising therapeutic target.
authors: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02139, USA.
authors: Tanya
authors: T
authors: Todorova
authors: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA 02139, USA.
authors: Florian J
authors: FJ
authors: Bock
authors: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02139, USA. Electronic address: pchang2@mit.edu.
authors: Paul
authors: P
authors: Chang
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007113:Immunity, Innate; D009369:Neoplasms / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D012313:RNA / Q000235:genetics* / Q000276:immunology; D016601:RNA-Binding Proteins / Q000276:immunology*; D053319:Tumor Necrosis Factor Decoy Receptors / Q000276:immunology
chemical_list: D016601:RNA-Binding Proteins; C451501:TNFRSF10D protein, human; D053319:Tumor Necrosis Factor Decoy Receptors; C527496:ZC3HAV1 protein, human; D012313:RNA
keywords: cancer; innate immune response; poly(ADP-ribose) polymerase-13; post-transcriptional RNA regulation; zinc-finger antiviral protein