title: Secondary metabolites of plants from the genus chloranthus: chemistry and biological activities.
abstract: Chloranthus, a genus of the family Chloranthaceae, which is mainly distributed in eastern and southern Asia, has been used in Chinese folk medicine due to its antitumor, antifungal, and anti-inflammatory activities. This review compiles the research on isolation, structure elucidation, structural diversity, and bioactivities of Chloranthus secondary metabolites reported between 2007 and 2013. The metabolites listed encompass 82 sesquiterpenoids, 50 dimeric sesquiterpenoids, 15 diterpenoids, one coumarin, and five other compounds. Among them, dimeric sesquiterpenoids, the characteristic components of plants from the genus Chloranthus, have attracted considerable attention due to their complex structures and significant biological features, e.g., antitumor, antibacterial, antifungal, anti-inflammatory, and hepatoprotective activities, and potent and selective inhibition of the delayed rectifier (IK) K(+) current and tyrosinase.
authors: Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), School of Life Science, Southwest University, Chongqing 400715, P. R. China, (phone: +86-23-68252400; fax: +86-23-68252365).
authors: An-Ran
authors: AR
authors: Wang
authors: Hong-Chuan
authors: HC
authors: Song
authors: Hong-Mei
authors: HM
authors: An
authors: Qian
authors: Q
authors: Huang
authors: Xie
authors: X
authors: Luo
authors: Jin-Yan
authors: JY
authors: Dong
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry* / Q000378:metabolism*; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D064210:Secondary Metabolism; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D012717:Sesquiterpenes; D014442:Monophenol Monooxygenase
keywords: Biological activity; Chloranthus; Coumarins; Secondary metabolites; Terpenoids