title: Stimulation of electron transport as potential novel therapy in Parkinson's disease with mitochondrial dysfunction.
abstract: Parkinson's disease (PD) is a neurodegenerative motor disorder characterized by the loss of dopaminergic neurons. This loss of dopaminergic neurons is the pathological hallmark of the disease that results in the characteristic motor syndrome. Restoration of dopamine levels is the basis of current therapy; however, this does not tackle the cause of the disease. While the aetiology of PD remains mostly elusive, mitochondrial dysfunction has been linked to (at least) part of the PD cases. In this review we discuss recent findings in Drosophila melanogaster showing that stimulation of the electron transport chain is beneficial for PD fly models showing Complex I defects and discuss the possible clinical applications of these findings.
authors: *Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
authors: Melissa
authors: M
authors: Vos
authors: †VIB Center for the Biology of Disease, Leuven, Belgium.
authors: Patrik
authors: P
authors: Verstreken
authors: *Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
authors: Christine
authors: C
authors: Klein
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D059290:Dopaminergic Neurons / Q000378:metabolism / Q000473:pathology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster; D042967:Electron Transport Complex I / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism; D000099202:PTEN-Induced Putative Kinase
chemical_list: D004298:Dopamine; D029721:Drosophila Proteins; D042967:Electron Transport Complex I; D017346:Protein Serine-Threonine Kinases; D044767:Ubiquitin-Protein Ligases; C534484:PINK1 protein, Drosophila; D000099202:PTEN-Induced Putative Kinase; C487430:park protein, Drosophila