title: Herbal mouthwash containing extracts of Baccharis dracunculifolia as agent for the control of biofilm: clinical evaluation in humans.
abstract: Baccharis dracunculifolia DC (Asteraceae), popularly known as "alecrim-do-campo," is largely distributed in South America, is shown to exhibit protective actions against gastric ulcers, has anti-inflammatory properties, and is hepatoprotective. Several essential oils obtained from Baccharis species possess biological activities, such as antimicrobial and antivirus activities. This randomized controlled trial evaluated the efficacy of B. dracunculifolia in the reduction of dental biofilm, comparing this natural product with other mouthwashes already known in the dental market. In measuring the time after use of mouthwash (t = 1), there was no difference between products (P = 0.602); that is, subjects in the study had a similar PI after the first use. After one week (t = 2), there was no difference between the four products evaluated (P = 0.674), so, all research individuals completed the study with a similar reduction in dental biofilm between themselves but it was different from initial state (Friedman test). It is possible to conclude that B. dracunculifolia had the same efficiency of the materials used to oral hygiene in reduction of dental plaque and, consequently, prevention of dental caries. Thus, we can consider B. dracunculifolia as a good candidate for new material to be implemented in dental care.
authors: Department of Dental Materials and Prosthodontics, Ribeirão Preto Dentistry Faculty, University of São Paulo, 14040-904 Ribeirão Preto, SP, Brazil.
authors: Vinícius
authors: 0000-0003-0701-6999
authors: V
authors: Pedrazzi
authors: Multidisciplinary Institute for Health, Federal University of Bahia, Anísio Teixeira Campus, 45029-094 Vitoria da Conquista, BA, Brazil.
authors: Mateus Freire
authors: MF
authors: Leite
authors: Department of Dental Materials and Prosthodontics, Ribeirão Preto Dentistry Faculty, University of São Paulo, 14040-904 Ribeirão Preto, SP, Brazil.
authors: Reisla Cristina
authors: RC
authors: Tavares
authors: Department of Dental Materials and Prosthodontics, Ribeirão Preto Dentistry Faculty, University of São Paulo, 14040-904 Ribeirão Preto, SP, Brazil.
authors: Sandra
authors: S
authors: Sato
authors: Department of Morphology, Physiology and Basic Pathology, Ribeirão Preto Dentistry Faculty, University of São Paulo, 14040-904 Ribeirão Preto, SP, Brazil.
authors: Glauce Crivelaro
authors: GC
authors: do Nascimento
authors: Department of Morphology, Physiology and Basic Pathology, Ribeirão Preto Dentistry Faculty, University of São Paulo, 14040-904 Ribeirão Preto, SP, Brazil.
authors: João Paulo Mardegan
authors: JP
authors: Issa
mesh_terms: D000293:Adolescent; D000328:Adult; D031175:Baccharis; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000008:administration & dosage*; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000302:isolation & purification; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification; D028321:Plant Preparations / Q000008:administration & dosage* / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D009067:Mouthwashes; D009822:Oils, Volatile; D010936:Plant Extracts; D028321:Plant Preparations