title: B cells in MS: Why, where and how?
abstract: Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS), in which auto-aggressive lymphocytes participate in inflammation that causes myelin destruction. Although T lymphocytes have been viewed as important culprits in the inflammatory cascade that results in MS, clinical trial results and animal model data support a role for B lymphocytes in MS pathology. In spite of these encouraging results, the mechanism behind why B cell depletion might be effective for MS treatment remains unknown. Herein we summarize the state of our knowledge for how B cells and their antibody products may influence the initiation and or propagation of MS, drawing from human studies and animal model data.
authors: Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
authors: Natalia
authors: N
authors: Pikor
authors: Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5S 1A8. Electronic address: jen.gommerman@utoronto.ca.
authors: Jennifer L
authors: JL
authors: Gommerman
keywords: Antibodies; B cells; EAE; Follicle-like Structures (FLS); MS; Neuroinflammation