title: Enantioselective total syntheses of (+)-hostmanin A, (-)-linderol A, (+)-methyllinderatin and structural reassignment of adunctin E.
abstract: A one-step protocol has been developed for the enantioselective synthesis of hexahydrodibenzofuran derivatives using a modified Friedel-Crafts reaction. The developed method was applied to the synthesis of a series of natural products including (+)-hostmanin A, (+)-methyllinderatin, and (-)-linderol A. The synthetic and spectroscopic data investigations led to the structural reassignment of natural product adunctin E, which was further confirmed by single-crystal X-ray analysis.
authors: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, India.
authors: Dattatraya H
authors: DH
authors: Dethe
authors: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, India.
authors: Balu D
authors: BD
authors: Dherange
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry*; D002185:Cannabidiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; D001688:Biological Products; C000603274:adunctin E; C000603273:hostmanin A; C429131:linderol A; C000603272:methyllinderatin; D002185:Cannabidiol