title: Different levels in alcohol and tobacco consumption in head and neck cancer patients from 1957 to 2013.
abstract: OBJECTIVE
  To provide a precise quantification of the association between alcohol and tobacco consumption trends in head and neck cancer patients over the past 45 years.
  
  
  METHODS
  We combined findings from all studies published until March 2014 and evaluated the association between different levels in alcohol and tobacco consumption and head and neck cancers through a meta-analytic approach.
  
  
  RESULTS
  We included 28 studies involving 13830 patients with head and neck cancer. In patients with alcohol consumption, the pooled odds ratio (OR) and 95% confidence interval (CI) were 1.29(1.06-1.57), 2.67(2.05-3.48) and 6.63(5.02-8.74) for light drinkers, moderate drinkers and heavy drinkers, respectively. In patients with tobacco consumption, the pooled OR and 95% CI were 2.33(1.84-2.95), 4.97(3.67-6.71) and 6.77(4.81-9.53) for light smokers, moderate smokers and heavy smokers, respectively.
  
  
  CONCLUSIONS
  The increased alcohol and tobacco consumption trends increased the risk of head and neck cancer over the past 45 years. Tobacco consumption was found to be a stronger risk factor for head and neck cancer than alcohol consumption. Thus, the control should be considered to limit the intake of alcohol and tobacco.
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China; Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Jiangsu Province, Nanjing, China.
authors: Yu
authors: Y
authors: Zhang
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
authors: Ruixia
authors: R
authors: Wang
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China; Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Centre, Nanjing Medical University, Nanjing, China.
authors: Limin
authors: L
authors: Miao
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
authors: Longbiao
authors: L
authors: Zhu
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China; Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Jiangsu Province, Nanjing, China.
authors: Hongbing
authors: H
authors: Jiang
authors: Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China; Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Jiangsu Province, Nanjing, China.
authors: Hua
authors: H
authors: Yuan
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D016022:Case-Control Studies; D006258:Head and Neck Neoplasms / Q000209:etiology*; D006801:Humans; D015201:Meta-Analysis as Topic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D013997:Time Factors