title: An exercise regimen prevents development paclitaxel induced peripheral neuropathy in a mouse model.
abstract: Peripheral neuropathy is a major, dose-limiting complication of many chemotherapeutic agents. Currently there is no effective method to prevent development of chemotherapy-induced peripheral neuropathy (CIPN). Recent studies have shown that exercise can improve regeneration of peripheral nerves but its effect in preventing peripheral neuropathy is unknown. In this study, we examined the effect of a rigorous treadmill exercise program that was started 1 week before administration of paclitaxel and continued throughout the study in a mouse model of CIPN. We showed that exercise can partially abrogate features of axonal degeneration induced by paclitaxel including reduction in epidermal nerve fiber density in the plantar hind paw and thermal hypoalgesia. Furthermore, detyrosinated tubulin that is elevated in nerves treated with paclitaxel was normal in exercised animals. This study points to a relatively simple and potentially effective therapeutic option to reduce the neurotoxic effects of chemotherapy.
authors: Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Jae Sung
authors: JS
authors: Park
authors: Department of Neuroscience, The Johns Hopkins University, Baltimore, MD, USA.
authors: Sangri
authors: S
authors: Kim
authors: Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors: Ahmet
authors: A
authors: Hoke
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D009431:Neural Conduction / Q000187:drug effects; D017239:Paclitaxel / Q000633:toxicity*; D017288:Pain Threshold / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D010805:Physical Conditioning, Animal
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel
keywords: exercise; neuropathy; paclitaxel