title: Wound healing following surgical and regenerative periodontal therapy.
abstract: Clinical studies have evaluated the effect of conventional periodontal surgical therapy. In general, although some clinical gain in tissue support may be attained, these therapies do not support regeneration of the periodontal attachment. Even though the biological possibility of periodontal regeneration has been demonstrated, the clinical application of this intrinsic potential appears difficult to harness; thus also conceptually most intriguing candidate protocols face clinical challenges. In this review, we explore the bioclinical principles, condiciones sine quibus non, that unleash the innate potential of the periodontium to achieve clinically meaningful periodontal regeneration (i.e. space-provision, wound stability and conditions for primary intention healing). Moreover, limiting factors and detrimental practices that may compromise clinical and biological outcomes are reviewed, as is tissue management in clinical settings.
authors: Cristiano
authors: C
authors: Susin
authors: Tiago
authors: T
authors: Fiorini
authors: Jaebum
authors: J
authors: Lee
authors: Jamie A
authors: JA
authors: De Stefano
authors: Douglas P
authors: DP
authors: Dickinson
authors: Ulf M E
authors: UM
authors: Wikesjö
mesh_terms: D018786:Bone Substitutes / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D048091:Guided Tissue Regeneration / Q000379:methods; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology / Q000627:therapeutic use; D010510:Periodontal Diseases / Q000628:therapy*; D010519:Periodontium / Q000502:physiology / Q000601:surgery*; D012038:Regeneration / Q000502:physiology*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D018786:Bone Substitutes; D036341:Intercellular Signaling Peptides and Proteins