title: Predicting and treating stress-induced vulnerability to epilepsy and depression.
abstract: Accumulation of stressful events can render individuals susceptible to develop epilepsy and comorbidities. Whether such vulnerability can be predicted and reversed is not known. Here we show that social defeat, although not producing depression by itself, produced in 50% of rats reduced threshold for status epilepticus (SE), accelerated epileptogenesis, and once epilepsy was induced, depression-like profile and cognitive deficits. Low serum brain-derived neurotrophic factor (BDNF) levels measured before SE identified this vulnerable population. Treatment with a BDNF analog before SE prevented the occurrence of comorbidities. Thus, vulnerability to comorbidities after epilepsy onset due to unresolved past stressful events may be predicted and reversed.
authors: Mixed Unit of Research 119 (UMPC UM 119), Pierre and Marie Curie University-Paris 6, Paris.|Unit 1130, National Institute of Health and Medical Research (INSERM 1130), Paris.|Unit 8246, National Center for Scientific Research (CNRS 8246), Paris.|Faculty of Medicine, Paris Descartes University, Sorbonne Paris Cité, Paris.
authors: Christel
authors: C
authors: Becker
authors: Mixed Unit of Research 119 (UMPC UM 119), Pierre and Marie Curie University-Paris 6, Paris.|Unit 1130, National Institute of Health and Medical Research (INSERM 1130), Paris.|Unit 8246, National Center for Scientific Research (CNRS 8246), Paris.
authors: Elodie
authors: E
authors: Bouvier
authors: Aix Marseille Université, INS, 13005, Marseille, France.|Inserm, UMR_S 1106, 13005, Marseille, France.
authors: Antoine
authors: A
authors: Ghestem
authors: Aix Marseille Université, INS, 13005, Marseille, France.|Inserm, UMR_S 1106, 13005, Marseille, France.
authors: Safia
authors: S
authors: Siyoucef
authors: Mixed Unit of Research 119 (UMPC UM 119), Pierre and Marie Curie University-Paris 6, Paris.|Unit 1130, National Institute of Health and Medical Research (INSERM 1130), Paris.|Unit 8246, National Center for Scientific Research (CNRS 8246), Paris.|Army Institute of Biomedical Research, Brétigny sur Orge.
authors: Damien
authors: D
authors: Claverie
authors: Mixed Unit of Research 119 (UMPC UM 119), Pierre and Marie Curie University-Paris 6, Paris.|Unit 1130, National Institute of Health and Medical Research (INSERM 1130), Paris.|Unit 8246, National Center for Scientific Research (CNRS 8246), Paris.
authors: Françoise
authors: F
authors: Camus
authors: Aix Marseille Université, INS, 13005, Marseille, France.|Inserm, UMR_S 1106, 13005, Marseille, France.
authors: Fabrice
authors: F
authors: Bartolomei
authors: Mixed Unit of Research 119 (UMPC UM 119), Pierre and Marie Curie University-Paris 6, Paris.|Unit 1130, National Institute of Health and Medical Research (INSERM 1130), Paris.|Unit 8246, National Center for Scientific Research (CNRS 8246), Paris.|Department of Biochemistry and Endocrine Oncology, Pitié-Salpêtrière Hospital, Paris, France.
authors: Jean-Jacques
authors: JJ
authors: Benoliel
authors: Aix Marseille Université, INS, 13005, Marseille, France.|Inserm, UMR_S 1106, 13005, Marseille, France.
authors: Christophe
authors: C
authors: Bernard
mesh_terms: D052636:Allostasis; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000187:drug effects / Q000378:metabolism*; D003072:Cognition Disorders / Q000378:metabolism* / Q000523:psychology; D003863:Depression / Q000378:metabolism* / Q000523:psychology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism / Q000523:psychology; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D047309:Flavones / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000378:metabolism*; D007608:Kainic Acid / Q000633:toxicity; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012931:Social Environment; D013226:Status Epilepticus / Q000139:chemically induced / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology
chemical_list: C485383:6,7-dihydroxyflavone; D019208:Brain-Derived Neurotrophic Factor; D018690:Excitatory Amino Acid Agonists; D047309:Flavones; D007608:Kainic Acid