title: The secretory pathway kinases.
abstract: Protein phosphorylation is a nearly universal post-translation modification involved in a plethora of cellular events. Even though phosphorylation of extracellular proteins had been observed, the identity of the kinases that phosphorylate secreted proteins remained a mystery until only recently. Advances in genome sequencing and genetic studies have paved the way for the discovery of a new class of kinases that localize within the endoplasmic reticulum, Golgi apparatus and the extracellular space. These novel kinases phosphorylate proteins and proteoglycans in the secretory pathway and appear to regulate various extracellular processes. Mutations in these kinases cause human disease, thus underscoring the biological importance of phosphorylation within the secretory pathway. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases.
authors: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors: Anju
authors: A
authors: Sreelatha
authors: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
authors: Lisa N
authors: LN
authors: Kinch
authors: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: Vincent.tagliabracci@UTSouthwestern.edu.
authors: Vincent S
authors: VS
authors: Tagliabracci
mesh_terms: D000015:Abnormalities, Multiple / Q000201:enzymology / Q000235:genetics*; D000818:Animals; D047389:Casein Kinase I / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002972:Cleft Palate / Q000201:enzymology / Q000235:genetics*; D004721:Endoplasmic Reticulum / Q000201:enzymology / Q000235:genetics; D005094:Exophthalmos / Q000201:enzymology / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006056:Golgi Apparatus / Q000201:enzymology / Q000235:genetics; D006801:Humans; D008831:Microcephaly / Q000201:enzymology / Q000235:genetics*; D009154:Mutation; D010026:Osteosclerosis / Q000201:enzymology / Q000235:genetics*; D010766:Phosphorylation / Q000235:genetics; D011487:Protein Conformation; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D055571:Secretory Pathway / Q000235:genetics*; D013379:Substrate Specificity
chemical_list: D016326:Extracellular Matrix Proteins; D011505:Protein-Tyrosine Kinases; C000594807:PKDCC protein, human; D047389:Casein Kinase I; C524449:FAM20C protein, human
keywords: Fam20C; Kinases; Raine syndrome; Secretory pathway