title: Is 3D MPRAGE better than the combination DIR/PSIR for cortical lesion detection at 3T MRI?
abstract: OBJECTIVE
  Based on the application of newer magnetic resonance imaging (MRI) acquisition sequences, the detection of cortical lesions (CL) in multiple sclerosis (MS) has significantly improved. Double inversion recovery (DIR) at 3T has increased the detection sensitivity and classification specificity when combined with phase sensitive inversion recovery (PSIR). Previous findings with 3D magnetization prepared rapid acquisition with gradient echo (MPRAGE) sequences, showed improved classification specificity of purely intracortical (IC) and mixed (MX) lesions, compared to the classification based on DIR/PSIR. Direct comparison between the detection of CL by 3D MPRAGE and by DIR/PSIR at 3T has not been evaluated.
  
  
  METHODS
  Eleven subjects were imaged on a 3T magnet. DIR/PSIR and 3D MPRAGE images were reviewed independently. Each image set was reviewed twice; only lesions detected on both sessions were scored. Review time per scan was ~5min for DIR/PSIR and ~15min for 3D MPRAGE.
  
  
  RESULTS
  We identified 141 CL (62 IC+79 MX) based on DIR/PSIR images vs. 93 (38 IC+55 MX) based on MPRAGE from all eleven patients. MPRAGE under-detected the number of CL in seven cases and over-detected the number of CL in three, only one case had the same number of CL on both sets of images.
  
  
  CONCLUSIONS
  Combination DIR/PSIR at 3T is superior to 3D MPRAGE for detection of cortical gray matter lesions in MS. The contrast-to-noise ratio of CL appears to be inferior on the MPRAGE images relative to DIR/PSIR.
authors: Multiple Sclerosis Research Group, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: flavia.m.nelson@uth.tmc.edu.
authors: Flavia
authors: F
authors: Nelson
authors: Department of Radiology and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Aziz
authors: A
authors: Poonawalla
authors: Department of Radiology and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Sushmita
authors: S
authors: Datta
authors: Multiple Sclerosis Research Group, Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Jerry
authors: J
authors: Wolinsky
authors: Department of Radiology and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, USA.
authors: Ponnada
authors: P
authors: Narayana
keywords: Cortical lesions; DIR; Gray matter; MPRAGE; MRI; Multiple Sclerosis