title: Study on inhibitory activity of chitosan-based materials against biofilm producing Pseudomonas aeruginosa strains.
abstract: Six antibiotic-resistant Pseudomonas aeruginosa strains, isolated from chronic diabetic foot infections, were chosen for studying the influence of different chitosan-based materials: chitosan solution and chitosan submicroparticles in both planktonic and 24 h-old biofilm-forming models. Chitosan solution occurred to be more effective in the reduction of bacterial populations than chitosan submicroparticles for both planktonic and biofilm-related Pseudomonas cells. It seems that the antimicrobial activity of the tested chitosan preparations depends on the individual bacterial strain susceptibility probably related to differences in the phenotypes and natural antioxidant abilities of Pseudomonas aeruginosa strains.
authors: Jagiellonian University Medical College, Department of Microbiology, 31-121 Kraków, Czysta, Poland kyziol@chemia.uj.edu.pl.
authors: Agnieszka
authors: A
authors: Machul
authors: Jagiellonian University Medical College, Department of Microbiology, 31-121 Kraków, Czysta, Poland.
authors: Diana
authors: D
authors: Mikołajczyk
authors: Jagiellonian University, Faculty of Chemistry, Kraków, Ingardena, Poland.
authors: Anna
authors: A
authors: Regiel-Futyra
authors: Jagiellonian University Medical College, Department of Microbiology, 31-121 Kraków, Czysta, Poland.
authors: Piotr B
authors: PB
authors: Heczko
authors: Jagiellonian University Medical College, Department of Microbiology, 31-121 Kraków, Czysta, Poland.
authors: Magdalena
authors: M
authors: Strus
authors: Department of Chemical Engineering, Nanoscience Institute of Aragon (INA), Zaragoza, Spain Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Zaragoza, Spain.
authors: Manuel
authors: M
authors: Arruebo
authors: Jagiellonian University, Faculty of Chemistry, Kraków, Ingardena, Poland.
authors: Grażyna
authors: G
authors: Stochel
authors: Jagiellonian University, Faculty of Chemistry, Kraków, Ingardena, Poland.
authors: Agnieszka
authors: A
authors: Kyzioł
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001672:Biocompatible Materials; D018441:Biofilms / Q000187:drug effects*; D048271:Chitosan / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000502:physiology; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D048271:Chitosan
keywords: Chitosan; Pseudomonas aeruginosa; antibacterial; biofilm; planktonic bacteria form