title: Anticardiolipin Antibodies in Children with Helicobacter pylori Infection.
abstract: BACKGROUND
  Anticardiolipin (aCL) antibodies are associated with thrombosis and have an important role in the etiology of diseases such as stroke and myocardial infarction whose etiologies were based on thrombosis. H. pylori has been proposed to be responsible for the pathophysiology of some diseases including stroke, myocardial infarction, thrombosis, and autoimmune diseases. From this point of view, we hypothesized a possible relationship between H. pylori infection and aCL antibodies and initially aimed to determine the prevalence of aCL antibody positivity in children with H. pylori infection.
  
  
  METHODS
  Anticardiolipin antibodies were studied in 84 patients before and after eradication therapy and in a control group including 40 children.
  
  
  RESULTS
  The pretreatment aCL IgA (median 12.78 APL/mL), aCL IgM (median 21.60 MPL/mL), and aCL IgG antibody levels (median 14.22 GPL/mL) were significantly higher than those of post-treatment results (median 5.38 APL/mL, 7.02 MPL/mL, and 6.64 GPL/mL, respectively) and controls (median 5.90 APL/mL, 4.80 MPL/mL, and 4.81 GPL/mL, respectively). Anticardiolipin antibodies revealed no significant differences between the study group after therapy and the control group.
  
  
  CONCLUSIONS
  In our particular experience, H. pylori can cause aCL antibody positivity in children and eradication of H. pylori provides the disappearance of these antibodies.
authors: Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
authors: Serdar Umit
authors: SU
authors: Sarıcı
authors: Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
authors: Orhan
authors: O
authors: Gursel
authors: Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
authors: Emin
authors: E
authors: Kurekci
authors: Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
authors: Vural
authors: V
authors: Kesik
authors: Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
authors: Avni
authors: A
authors: Atay
authors: Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
authors: Vedat
authors: V
authors: Okutan
authors: Department of Immunology, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
authors: Ali
authors: A
authors: Inal
authors: Department of Immunology, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
authors: Aysel
authors: A
authors: Pekel
authors: Department of Nuclear Medicine, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
authors: Mehmet Ali
authors: MA
authors: Ozguven
authors: Department of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
authors: Okan
authors: O
authors: Ozcan
mesh_terms: D000293:Adolescent; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D002648:Child; D005260:Female; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D008297:Male
chemical_list: D017153:Antibodies, Anticardiolipin
keywords: H. pylori; anticardiolipin antibodies; children