title: Peripheral giant cell granuloma associated with a dental implant: a case report and review of the literature.
abstract: The peripheral giant cell granuloma (PGCG) is a nonneoplastic lesion commonly caused by local irritation. This report describes a 46-year-old Caucasian male who presented with a PGCG associated with a dental implant. The dental implant was originally placed in August 2012. Ten months later, the patient presented with a well-circumscribed lesion associated with and covering the implant, at which time the lesion was excised. Four months later, due to recurrence of the lesion, a deeper and wider excisional biopsy with curettage of the adjacent bone was performed. No evidence of recurrence has been reported after 12 months of follow-up. Immunohistochemistry, using the antibody CD68, was performed to investigate the origin of the multinucleated giant cells, with their immunophenotype being similar to those of other giant cell lesions, including central giant cell granuloma, foreign-body reactions, and granulomatous reactions to infectious agents.
authors: Department of Pathology, São Leopoldo Mandic Institute and Research Centre, 13045-755 Campinas, SP, Brazil.
authors: Amy Louise
authors: AL
authors: Brown
authors: Department of Oral Medicine and Oral Surgery, São Leopoldo Mandic Institute and Research Centre, 13045-755 Campinas, SP, Brazil.
authors: Paulo
authors: P
authors: Camargo de Moraes
authors: Department of Pathology, São Leopoldo Mandic Institute and Research Centre, 13045-755 Campinas, SP, Brazil.
authors: Marcelo
authors: M
authors: Sperandio
authors: Department of Pathology, São Leopoldo Mandic Institute and Research Centre, 13045-755 Campinas, SP, Brazil.
authors: Andresa
authors: A
authors: Borges Soares
authors: Department of Pathology, São Leopoldo Mandic Institute and Research Centre, 13045-755 Campinas, SP, Brazil.
authors: Vera Cavalcanti
authors: VC
authors: Araújo
authors: Department of Pathology, São Leopoldo Mandic Institute and Research Centre, 13045-755 Campinas, SP, Brazil.
authors: Fabrício
authors: F
authors: Passador-Santos