title: MicroRNAs regulate bone development and regeneration.
abstract: MicroRNAs (miRNAs) are endogenous small noncoding ~22-nt RNAs, which have been reported to play a crucial role in maintaining bone development and metabolism. Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone formation is inseparable from the delicate regulation of various miRNAs. Of note, apprehending the sophisticated circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone defects. In this review, we highlight how different miRNAs interact with diverse osteo-related genes and endeavor to sketch the contours of potential manipulations of miRNA-modulated bone repair.
authors: Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China. fangsijie89@hotmail.com.
authors: Sijie
authors: S
authors: Fang
authors: Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China. ophden@163.com.
authors: Yuan
authors: Y
authors: Deng
authors: Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China. guping2009@hotmail.com.
authors: Ping
authors: P
authors: Gu
authors: Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China. fanxq@sh163.net.
authors: Xianqun
authors: X
authors: Fan
mesh_terms: D000818:Animals; D001846:Bone Development / Q000235:genetics* / Q000502:physiology; D001842:Bone and Bones / Q000502:physiology*; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D010006:Osteoblasts / Q000502:physiology; D010012:Osteogenesis / Q000235:genetics* / Q000502:physiology; D012038:Regeneration / Q000235:genetics* / Q000502:physiology
chemical_list: D035683:MicroRNAs