title: Association between interleukin 17A polymorphisms and susceptibility to rheumatoid arthritis in a Chinese population.
abstract: BACKGROUND
  Previous studies have revealed an association between interleukin 17A (IL17A) polymorphisms and the prevalence of rheumatoid arthritis (RA) in Japanese and Caucasian patients. We hypothesized that IL17A polymorphisms might also affect RA susceptibility in the Chinese population.
  
  
  METHODS
  We studied IL17A rs2275913 G/A, rs3819024 A/G, rs3819025 G/A, rs4711998 A/G, rs8193036 C/T and rs8193037 G/A polymorphisms in 615 RA patients and 839 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex SNP scan™ Kit.
  
  
  RESULTS
  Our results indicated that IL17A rs4711998 A/G and IL17A rs8193037 G/A polymorphisms were not associated with RA, and IL17A rs2275913 G/A and IL17A rs3819024 A/G variant alleles decrease the risk of RA, while IL17A rs3819025 G/A and IL17A rs8193036 C/T variant alleles increase the risk of RA.
  
  
  CONCLUSIONS
  These findings suggest that IL17A polymorphisms may be associated with RA. Future larger studies with other ethnic populations are required to confirm current findings.
authors: Department of Clinical Laboratory, Changzhou First People's Hospital, Changzhou 213003, China.
authors: Li
authors: L
authors: Shen
authors: Department of Orthopaedic Trauma, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China.
authors: Hui
authors: H
authors: Zhang
authors: Department of Orthopaedic Trauma, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China.
authors: Ting
authors: T
authors: Yan
authors: Department of Orthopaedic Trauma, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China.
authors: Guoxin
authors: G
authors: Zhou
authors: Department of Orthopaedic Trauma, Affiliated Hospital of Nanjing Medical University, Changzhou Second People's Hospital, Changzhou 213003, China; Central Laboratory, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China. Electronic address: lrp216@sina.com.
authors: Ruiping
authors: R
authors: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D020381:Interleukin-17
keywords: Interleukin 17A; Molecular epidemiology; Polymorphisms; Rheumatoid arthritis