title: CRIT-LINE: a noninvasive tool to monitor hemoglobin levels in pediatric hemodialysis patients.
abstract: BACKGROUND
  The national average for achieving the KDOQI-recommended hemoglobin (Hgb) target level of 11-12 g/dL is low with the current anemia management protocol of measuring Hgb levels every 2-4 weeks to guide intervention. The objective of this study was to correlate initial Hgb readings from the CRIT-LINE monitor with actual serum Hgb levels in pediatric patients on hemodialysis (HD).
  
  
  METHODS
  Data were collected from pediatric HD patients who had Hgb tests ordered for routine and/or clinical reasons. Hgb concentrations were read with the CRIT-LINE after 0.5 or 1 L of blood had been processed by HD in patients with a body weight of ≤20 or >20 kg, respectively. Ultrafiltration was kept at a minimum until the CRIT-LINE Hgb was read.
  
  
  RESULTS
  In total, 217 Hgb readings from 23 HD patients were analyzed. Results showed a statistically significant correlation between CRIT-LINE readings and laboratory Hgb measurements (r = 0.94, p < 0.0001) using Pearson correlation coefficients for well-distributed data. The mean Hgb levels measured by CRIT-LINE and the laboratory were 11.12 ± 1.63 and 11.31 ± 1.69 g/dL, respectively.
  
  
  CONCLUSIONS
  The CRIT-LINE monitor is an accurate instrument for monitoring Hgb levels in HD patients. Further studies will be needed to evaluate whether using CRIT-LINE Hgb levels to guide anemia management will improve the percentage of children with Hgb levels within target.
authors: Department of Pediatrics, Division of Nephrology, Emory University, 2015 Uppergate Drive NE, Atlanta, GA, 30322, USA, rgarro@emory.edu.
authors: Rouba
authors: R
authors: Garro
authors: Scott
authors: S
authors: Sutherland
authors: Liz
authors: L
authors: Bayes
authors: Steven
authors: S
authors: Alexander
authors: Cynthia
authors: C
authors: Wong
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000740:Anemia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004867:Equipment Design; D005260:Female; D006397:Hematinics / Q000627:therapeutic use; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D011237:Predictive Value of Tests; D006435:Renal Dialysis / Q000009:adverse effects; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006397:Hematinics; D006454:Hemoglobins