title: [Efficacy observation of 0.1% bromfenac sodium eye drops on relieving the post-LASEK irritative symptoms].
abstract: OBJECTIVE
  To observe the efficacy of bromfenac sodium eye drops on relieving the irritative symptoms after LASEK surgery.
  
  
  METHODS
  Sixty-four people who had received LASEK surgery were randomly divided into two groups, observing the right eye for each group. group A was given 0.1% bromfenac sodium eye drops twice a day in three days before surgery and one day after surgery; group B was given 0.5% ketorolac tromethamine (acular) eye drops four times a day in three days before surgery and on day after surgery. In the 1(st), 3(rd), 5(th) and 7(th) day after surgery, irritative symptoms grade, duration of irritation, time for corneal epithelial healing, and uncorrected visual acuity were observed and compared between the two groups.
  
  
  RESULTS
  0.1% no discomfort in group A with bromfenac sodium eye drops was observed while 0.5% ketorolac tromethamine eye drops caused tingling, burning discomfort that lasted for 2-3 seconds in 16 of the 28 subjects (87.5%). No significant difference was observed between the irritation grades of group A and B (Z = -1.625, P = 0.104); the duration of irritative symptom was significantly shorter in group A than that in group B (Z = -2.895, P = 0.004) . No significant difference was observed between the time of healing and visual acuity recovery of the two groups.
  
  
  CONCLUSIONS
  0.1% bromfenac sodium eye drops can effectively relieve the post-LASEK irritative symptoms, and it is better tolerated than 0.5% ketorolac tromethamine eye drops.
authors: Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.
authors: Yuan
authors: Y
authors: Dong
authors: Yu
authors: Y
authors: Zhang
authors: Yingjie
authors: Y
authors: Xia
authors: Bing
authors: B
authors: Wang
authors: Email: chenyueguo@263.net.
authors: Yueguo
authors: Y
authors: Chen
mesh_terms: D000328:Adult; D001577:Benzophenones / Q000627:therapeutic use*; D001969:Bromobenzenes / Q000627:therapeutic use*; D003315:Cornea / Q000187:drug effects*; D005260:Female; D006801:Humans; D049008:Keratectomy, Subepithelial, Laser-Assisted / Q000009:adverse effects*; D020911:Ketorolac Tromethamine / Q000627:therapeutic use*; D008297:Male; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D014792:Visual Acuity; D014945:Wound Healing
chemical_list: D001577:Benzophenones; D001969:Bromobenzenes; D009883:Ophthalmic Solutions; D020911:Ketorolac Tromethamine; C053083:bromfenac