title: Bridging the Gap: The Potential Role of Corticosteroid Binding Globulin in Cardiac Steroid Facilitation.
abstract: Corticosteroid (glucocorticoids [GCs] and mineralcorticoids [MCs]) interact directly with cells of the cardiovascular system. Their signaling affects genomic and non-genomic receptors and comprises a multitude of alternative and interfering levels of interaction, which influence the physiological response. This review describes genomic and non-genomic pathways of steroid facilitation and portrays the current body of knowledge regarding corticosteroid-binding globulin (CBG). The latter is a carrier protein facilitating corticosteroid availability in the circulation and has recently been discovered intrinsically in cardiomyocytes. Thought experiments highlight potential areas of clinical research and hypotheses are presented for steroid- carrier interaction. Furthermore, this review comprises a conclusive overview of disease conditions and substances that influence CBG levels and summarizes the potential of CBG as a potential future biomarker.
authors: F. Hoffmann-La Roche Ltd, Diagnostics Division, Divisional Medical and Scientific Affairs, Grenzacherstrasse 124, 4070 Basel, Switzerland. Hendrik.Schaefer@gmx.ch.
authors: Hans Hendrik
authors: HH
authors: Schafer
authors: Thomas
authors: T
authors: Dieterle
authors: Aaron
authors: A
authors: Trachsler
authors: Mikael
authors: M
authors: Gencay
authors: Edelgard Anna
authors: EA
authors: Kaiser
mesh_terms: D000450:Aldosterone / Q000502:physiology; D000818:Animals; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006801:Humans; D008901:Mineralocorticoids / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014156:Transcortin / Q000187:drug effects / Q000502:physiology*
chemical_list: D005938:Glucocorticoids; D008901:Mineralocorticoids; D000450:Aldosterone; D014156:Transcortin