title: Extending the amygdala in theories of threat processing.
abstract: The central extended amygdala is an evolutionarily conserved set of interconnected brain regions that play an important role in threat processing to promote survival. Two core components of the central extended amygdala, the central nucleus of the amygdala (Ce) and the lateral bed nucleus of the stria terminalis (BST) are highly similar regions that serve complimentary roles by integrating fear- and anxiety-relevant information. Survival depends on the ability of the central extended amygdala to rapidly integrate and respond to threats that vary in their immediacy, proximity, and characteristics. Future studies will benefit from understanding alterations in central extended amygdala function in relation to stress-related psychopathology.
authors: Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA; HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, WI, USA; Lane Neuroimaging Laboratory, University of Wisconsin-Madison, Madison, WI, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, USA; Center for Investigating Healthy Minds at the Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: asfox@wisc.edu.
authors: Andrew S
authors: AS
authors: Fox
authors: Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA; HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, WI, USA; Lane Neuroimaging Laboratory, University of Wisconsin-Madison, Madison, WI, USA.
authors: Jonathan A
authors: JA
authors: Oler
authors: Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA; HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, WI, USA; Lane Neuroimaging Laboratory, University of Wisconsin-Madison, Madison, WI, USA.
authors: Do P M
authors: do PM
authors: Tromp
authors: Department of Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, NY, USA; Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.
authors: Julie L
authors: JL
authors: Fudge
authors: Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA; HealthEmotions Research Institute, University of Wisconsin-Madison, Madison, WI, USA; Lane Neuroimaging Laboratory, University of Wisconsin-Madison, Madison, WI, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, USA; Center for Investigating Healthy Minds at the Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.
authors: Ned H
authors: NH
authors: Kalin
mesh_terms: D000679:Amygdala / Q000166:cytology* / Q000502:physiology*; D000818:Animals; D005239:Fear; D015870:Gene Expression; D006801:Humans; D009434:Neural Pathways; D059906:Neuroimaging; D009474:Neurons / Q000502:physiology*
keywords: anxiety; cross-species; extended amygdala; gene expression connectivity; neuroimaging