title: Association of LPHN3 rs6551665 A/G polymorphism with attention deficit and hyperactivity disorder in Korean children.
abstract: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable disorder of school-age children. Its heritability was estimated at 80-90% but the genetic component underpinning this disorder remains to be disclosed. Recently, a highly consistent association between latrophilin3 (LPHN3) gene and ADHD was reported. In the present study, we examined the association between the LPHN3 rs6551665 A/G polymorphism and ADHD in Korea. The samples used in the study consisted of 150 ADHD children and 322 controls. The ADHD children were diagnosed according to DSM-IV. ADHD symptoms were evaluated with Dupaul Parent ADHD Rating Scales. LPHN3 rs6551665 SNP was determined by PCR-RFLP. Hardy-Weinberg equilibrium, genotype and allele frequency differences between the case and the control, and odds ratio were examined using the chi-square and exact tests. The LPHN3 gene locus was found to have no deviation from the Hardy-Weinberg expectation. We observed a significant association between the ADHD children and control group in genotype frequency (p=0.01) and allele frequency (p=0.02). The ADHD children appeared to have a surplus of GG genotype (OR 2.959, 95% CI 1.416-6.184, p=0.003) and G allele (OR 1.44, 95% CI 1.062-1.945, p=0.02). The association was more distinctive when analysis was confined to male samples (p=0.005), the OR of male controls and cases was 4.029 (95% CI 1.597-10.164, p=0.002) and the OR having G allele vs. A allele was 1.46 (95% CI 1.002-2.127, p=0.048). Thus our results imply that the LPHN3 rs6551665 GG genotype and G allele may provide a significant effect on the ADHD, although larger sample sizes and functional studies are necessary to further elucidate these findings.
authors: Department of Nanobiomedical Science, College of Natural Science, Dankook University, Cheonan, South Korea; Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea.
authors: In Wook
authors: IW
authors: Hwang
authors: Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea; Department of Psychology, College of Public Welfare, Dankook University, Cheonan, South Korea.
authors: Myung Ho
authors: MH
authors: Lim
authors: Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea; Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan, South Korea.
authors: Ho Jang
authors: HJ
authors: Kwon
authors: Department of Nanobiomedical Science, College of Natural Science, Dankook University, Cheonan, South Korea; Environmental Health Center, Dankook Medical Hospital, Cheonan, South Korea. Electronic address: jins4658@dankook.ac.kr.
authors: Han Jun
authors: HJ
authors: Jin
mesh_terms: D044466:Asian People / Q000235:genetics; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D018000:Receptors, Peptide / Q000235:genetics*
chemical_list: C513284:ADGRL3 protein, human; D043562:Receptors, G-Protein-Coupled; D018000:Receptors, Peptide
keywords: ADHD; Children; Genetic association; Korean; LPHN3; Polymorphism; rs6551665