title: Copper(I)-catalyzed intramolecular hydroalkoxylation of unactivated alkenes.
abstract: A Cu(I)-Xantphos system catalyzed the intramolecular hydroalkoxylation of unactivated terminal alkenes, giving five- and six-membered ring ethers. This system is applicable to both primary and secondary alcohols. A reaction pathway involving the addition of the Cu-O bond across the C-C double bond is proposed. A chiral Cu(I) catalyst system based on the (R)-DTBM-SEGPHOS ligand promoted enantioselective reaction with moderate enantioselectivity.
authors: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
authors: Hiroaki
authors: H
authors: Murayama
authors: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
authors: Kazunori
authors: K
authors: Nagao
authors: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
authors: Hirohisa
authors: H
authors: Ohmiya
authors: Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
authors: Masaya
authors: M
authors: Sawamura