title: Liver-Stage Specific Response among Endemic Populations: Diet and Immunity.
abstract: Developing effective anti-malarial vaccine has been a challenge for long. Various factors including complex life cycle of parasite and lack of knowledge of stage specific critical antigens are some of the reasons. Moreover, inadequate understanding of the immune responses vis-à-vis sterile protection induced naturally by Plasmodia infection has further compounded the problem. It has been shown that people living in endemic areas take years to develop protective immunity to blood stage infection. But hardly anyone believes that immunity to liver-stage infection could be developed. Various experimental model studies using attenuated parasite suggest that liver-stage immunity might exist among endemic populations. This could be induced because of the attenuation of parasite in liver by various compounds present in the diet of endemic populations.
authors: Institute of Science, Nirma University , Ahmedabad , India.
authors: Sarat Kumar
authors: SK
authors: Dalai
authors: Institute of Science, Nirma University , Ahmedabad , India.
authors: Naveen
authors: N
authors: Yadav
authors: Institute of Science, Nirma University , Ahmedabad , India.
authors: Manoj
authors: M
authors: Patidar
authors: Institute of Science, Nirma University , Ahmedabad , India.
authors: Hardik
authors: H
authors: Patel
authors: Infectious Diseases Laboratory, National Institute of Immunology , New Delhi , India.
authors: Agam Prasad
authors: AP
authors: Singh
keywords: Plasmodia; chloroquine and chemoprophylaxis; liver-stage immunity; natural habit; sterile protection