title: A Severe Case of Recalcitrant Pompholyx.
abstract: BACKGROUND
  Pompholyx is an inflammatory vesiculobullous skin disease of the hands and feet belonging to the spectrum of eczema.
  
  
  OBJECTIVE
  To report a severe case of pompholyx, its clinical presentation, and its management.
  
  
  METHODS
  A medical chart review was conducted on a patient with this condition.
  
  
  RESULTS
  The patient was patch tested according to the North American Contact Dermatitis Group (NACDG) Standard Screening Series, and results were negative. In the past, she was treated with corticosteroid creams as well as narrow band ultraviolet B (UVB), and Psoralen ultraviolet A (PUVA) therapies, and none were beneficial. When the frequency of the episodes increased, methotrexate was introduced but failed to control the condition. Next, mycophenolate mofetil was started and gradually increased to 3.5 g daily along with a separate trial of radiotherapy with marked success.
  
  
  CONCLUSIONS
  Pompholyx can be challenging to manage, and treatment can involve an assortment of therapies over a prolonged period of time.
authors: University of Ottawa, Ottawa, ON, Canada jgill089@uottawa.ca.
authors: Jeewanjit
authors: J
authors: Gill
authors: The Ottawa Hospital, Ottawa, ON, Canada.
authors: Melanie
authors: M
authors: Pratt
mesh_terms: D000328:Adult; D001768:Blister / Q000473:pathology; D011146:Eczema, Dyshidrotic / Q000473:pathology* / Q000628:therapy*; D005260:Female; D005385:Fingers / Q000473:pathology; D006801:Humans
keywords: dermatitis; immunology