title: [The low content of apolipoprotein E as a risk factor of increasing of ratio apolipoprotein B/A-1 in healthy males with normal lipemia].
abstract: The relationship of ratio of apolipoprotein (apo) B/apoA-1 with other indicators of lipid metabolism in healthy people with normal lipemia was analyzed. The dependence of ratio of apolipoprotein (apo) B/apoA-1 from content of apoE (X2=8.20; p=0.042) was established. Under low indicators of apoE risk of detection of unfavorable ratio apolipoprotein (apo) B/apoA-1 (higher than 0.9) increases (probability ratio 0.61, CI 95% 0.41-0.88, p=0.009). It is possible that low content of apoE results in deceleration of elimination and accumulation of lipoproteins in blood. This occurrence is followed by alteration of balance between apoE and apoA-1. In general, among patients with unfavorable ratio apoB/apoA-1 in spite of normal lipemia were detected higher indicators of triglycerides and atherogenic index of plasma and lower values of ratio of cholesterol lipoproteins of low density and apoB. This observation indicates on increasing of quantity triglyceride-reach lipoproteins and little solid lipoproteins of low density. Therefore, low content of apoE in blood can be considered as a predictor of increasing of ratio apoB/apoA-1 in healthy persons.
authors: A M
authors: AM
authors: Kaneva
authors: N N
authors: NN
authors: Potolitsyna
authors: A Iu
authors: AIu
authors: Liudinina
authors: N Zh
authors: NZh
authors: Alisultanova
authors: E R
authors: ER
authors: Boĭko
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D001057:Apolipoproteins E / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000473:pathology; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D001057:Apolipoproteins E