title: Evaluation of an antimicrobial silver foam dressing.
abstract: CuraVAC Ag, a product that delivers negative pressure wound therapy through a polyurethane foam dressing, contains silver nanoparticles, which, when moistened with water, release silver ions onto a wound surface. The in vitro antimicrobial action of silver can destroy both gram-positive and gram-negative bacteria, as well as methicillin-resistant Staphylococcus aureus (MRSA). The purpose of this study was to assess the efficacy and in vivo outcomes of using the product.
  
  
  METHODS
  Thirty-six female Sprague-Dawley white rats, 8-weeks old and 250 g - 300 g in weight, were used. The experimental product was prepared using a vacuum-assisted closure (VAC) kit and coating it using the silver nanoparticles. For the control group, a 10% povidone-iodine solution was applied.
  
  
  RESULTS
  All groups showed decreases in wound area over time, in the order CuraVAC Ag (group A) > CuraVAC (group B) > control (group C). On the third, fifth, and seventh days, wound healing efficacy scores increased in both group A and group C. Groups A and B showed more rapid decreases than group C in bacterial culture from wounds.
  
  
  CONCLUSIONS
  CuraVAC Ag may be useful for treatment of wounds infected with bacteria.﻿﻿﻿.
authors: CG Bio Co, Ltd, Kyunggi-Do, Republic of Korea.
authors: Jun Kyu
authors: JK
authors: Park
authors: Department of Plastic and Reconstructive Surgery, Eulji University School of Medicine, Eulji General Hospital, Seoul, Korea.
authors: Jong Hoon
authors: JH
authors: Lee
authors: Department of Pathology, Soonchunhyang University, Gyeonggi-Do, Republic of Korea.
authors: Jeong Ja
authors: JJ
authors: Kwak
authors: Departments of Laboratory Medicine and Genetics, Soonchunhyang University, Gyeonggi-Do, Republic of Korea.
authors: Hee Bong
authors: HB
authors: Shin
authors: Department of Nephrology, Incheon Saranghospital, Incheon-Si, Republic of Korea.
authors: Hae Won
authors: HW
authors: Jung
authors: Department of Orthopedic Surgery, Baroseum Hospital, Daejeon-Si, Republic of Korea.
authors: Sang Won
authors: SW
authors: Bae
authors: Department of Orthopedic Surgery, Soonchunhyang University, Gyeonggi-Do, Republic of Korea.
authors: Eui Dong
authors: ED
authors: Yeo
authors: Department of Orthopedic Surgery, Soonchunhyang University, Gyeonggi-Do, Republic of Korea; email: brain0808@hanmail.net.
authors: Young Koo
authors: YK
authors: Lee
authors: Department of Orthopedic Surgery, College of Medicine, Soonchunyang University Bucheon Hospital, Republic of Korea.
authors: Seong Seok
authors: SS
authors: Yang