title: [Individual patient data meta-analyses of randomized trials for the treatment of non-metastatic head and neck squamous cell carcinomas: Principles, results and perspectives].
abstract: Meta-analyses are considered as an important pillar of evidence-based medicine. The aim of this review is to describe the main principles of a meta-analysis and to use examples of head and neck oncology to demonstrate their clinical impact and methodological interest. The major role of individual patient data is outlined, as well as the superiority of individual patient data over meta-analyses based on published summary data. The major clinical breakthrough of head and neck meta-analyses are summarized, regarding concomitant chemotherapy, altered fractionated chemotherapy, new regimens of induction chemotherapy or the use of radioprotectants. Recent methodological developments are described, including network meta-analyses, the validation of surrogate markers. Lastly, the future of meta-analyses is discussed in the context of personalized medicine.
authors: Service de biostatistique et d'épidémiologie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France; Département de radiothérapie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France; Inserm U1018, CESP, Université Paris-Sud, Villejuif, France. Electronic address: pierre.blanchard@gustaveroussy.fr.
authors: P
authors: P
authors: Blanchard
authors: CHU de Vaudois, rue du Bugnon 21, 1011 Lausanne, Suisse.
authors: J
authors: J
authors: Bourhis
authors: Service de biostatistique et d'épidémiologie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France; Inserm U1018, CESP, Université Paris-Sud, Villejuif, France; Plateforme Ligue nationale contre le cancer de méta-analyse en oncologie, Gustave-Roussy, Villejuif, France.
authors: B
authors: B
authors: Lacas
authors: Service de biostatistique et d'épidémiologie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France; Inserm U1018, CESP, Université Paris-Sud, Villejuif, France; Plateforme Ligue nationale contre le cancer de méta-analyse en oncologie, Gustave-Roussy, Villejuif, France.
authors: G
authors: G
authors: Le Teuff
authors: Service de biostatistique et d'épidémiologie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France; Inserm U1018, CESP, Université Paris-Sud, Villejuif, France; Plateforme Ligue nationale contre le cancer de méta-analyse en oncologie, Gustave-Roussy, Villejuif, France.
authors: S
authors: S
authors: Michiels
authors: Service de biostatistique et d'épidémiologie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France; Inserm U1018, CESP, Université Paris-Sud, Villejuif, France; Plateforme Ligue nationale contre le cancer de méta-analyse en oncologie, Gustave-Roussy, Villejuif, France.
authors: J-P
authors: JP
authors: Pignon
mesh_terms: D004999:Amifostine / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D059248:Chemoradiotherapy; D019583:Dose Fractionation, Radiation; D019317:Evidence-Based Medicine; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D015201:Meta-Analysis as Topic; D009303:Nasopharyngeal Neoplasms / Q000628:therapy; D010039:Otorhinolaryngologic Neoplasms / Q000628:therapy; D011832:Radiation Injuries / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012074:Remission Induction; D012107:Research Design
chemical_list: D015415:Biomarkers; D016166:Free Radical Scavengers; D004999:Amifostine
keywords: Cancers des voies aérodigestives supérieures; Chemotherapy; Chimiothérapie; Critère de jugement de substitution; Données individuelles; Essais randomisés; Head and neck cancer; Individual patient data; Meta-analysis; Méta-analyse; Méta-analyse en réseau; Network meta-analysis; Radiotherapy; Radiothérapie; Randomized trials; Surrogate marker