title: Prognostic factors and survival in patients treated surgically for primary and recurrent uterine leiomyosarcoma: a single center experience.
abstract: OBJECTIVE
  To (i) determine prognostic factors after initial surgery for uterine leiomyosarcomas (LMS) and their recurrence and (ii) assess the effectiveness of re-resections.
  
  
  METHODS
  All cases that underwent surgery for uterine leiomyosarcomas at the Fundeni Clinical Institute, Bucharest between 2002 and 2013 were reviewed. Twenty-six patients with primary uterine leiomyosarcomas were introduced in our study. Sixteen of them were re-addressed to the same hospital for recurrence.
  
  
  RESULTS
  At the moment of initial surgery the most important prognostic factors were age <60 years, International Federation of Gynecology and Obstetrics (FIGO) stage I, tumor dimension <15 cm and mitotic index <15/10 high-power fields (HPF). The five-year overall survival was 40%. Sixteen patients were re-operated for recurrence; the most important prognostic factors being a late recurrence (>12 months) and initial FIGO stage I. The five-year overall survival was 12.5%.
  
  
  CONCLUSIONS
  Uterine leiomyosarcoma is an aggressive malignancy with a high rate of recurrence. In selected cases surgery may be attempted for re-recurrence.
authors: Carol Davila U.M.F., Bucharest, Romania irinel.popescu220@gmail.com nicolae_bacalbasa@yahoo.ro nicolaebacalbasa@gmail.com.
authors: Nicolae
authors: N
authors: Bacalbasa
authors: Ponderas Hospital, Bucharest, Romania.
authors: Irina
authors: I
authors: Balescu
authors: Dan Setlacec Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
authors: Simona
authors: S
authors: Dima
authors: Dan Setlacec Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
authors: Vladislav
authors: V
authors: Brasoveanu
authors: Carol Davila U.M.F., Bucharest, Romania Dan Setlacec Center of Gastrointestinal Disease and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania irinel.popescu220@gmail.com nicolae_bacalbasa@yahoo.ro nicolaebacalbasa@gmail.com.
authors: Irinel
authors: I
authors: Popescu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D011379:Prognosis; D014594:Uterine Neoplasms / Q000473:pathology / Q000601:surgery*
keywords: Uterine leiomyosarcomas; complete resection; recurrence