title: Osteocytes and Homeostasis of Remote Organs : Bone-Buried Osteocytes Talk to Remote Organs.
abstract: The study of bones has attracted researchers from many medical fields. To understand bone-organ interactions, hematologists were challenged to investigate bone marrow (BM), the core of bone where hematopoiesis takes place. Through studies of the hematopoietic stem cells niche, hematologists contributed to the discovery of unexpected functions of bone-forming osteoblasts and bone-buried osteocytes. In particular, the recent findings about osteocytes, as the regulatory system of lympho-hematopoiesis and fat metabolism, highlighted the central role of skeletal tissue in inter-organ communication. The cross-cutting consideration including hematology and many other fields will expand the bone research.
authors: Department of Oral Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, Kita13 Nishi7, Kita-ku, Sapporo, Hokkaido, 060-8586, Japan, satomari@den.hokudai.ac.jp.
authors: Mari
authors: M
authors: Sato
authors: Yoshio
authors: Y
authors: Katayama
mesh_terms: D000818:Animals; D005223:Fats / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D051379:Mice; D010011:Osteocytes / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D005223:Fats