title: Sustained complete remission of steroid- and cyclophosphamide-resistant minimal-change disease with a single course of rituximab therapy.
abstract: We report a case of steroid- and cyclophosphamide-resistant nephrotic syndrome secondary to minimal-change disease occurring in an otherwise healthy 19-year-old female, responding rapidly to two doses of rituximab therapy. Complete disease remission has been sustained up to last follow-up (32 months) despite CD19 recovery. Literature review suggests emerging evidence that rituximab may have a role to play in recurrent and/or refractory minimal-change disease.
authors: Dept Renal Medicine , Alfred Hospital , Melbourne , Australia.
authors: Jyotsna
authors: J
authors: Janardan
authors: Dept Renal Medicine , Alfred Hospital , Melbourne , Australia.
authors: Khai
authors: K
authors: Ooi
authors: Dept Renal Medicine , Alfred Hospital , Melbourne , Australia.
authors: Solomon
authors: S
authors: Menahem
keywords: minimal-change disease; nephrotic syndrome; rituximab; steroid resistance