title: Amelioration of Auditory Response by DA9801 in Diabetic Mouse.
abstract: Diabetes mellitus (DM) is a metabolic disease that involves disorders such as diabetic retinopathy, diabetic neuropathy, and diabetic hearing loss. Recently, neurotrophin has become a treatment target that has shown to be an attractive alternative in recovering auditory function altered by DM. The aim of this study was to evaluate the effect of DA9801, a mixture of Dioscorea nipponica and Dioscorea japonica extracts, in the auditory function damage produced in a STZ-induced diabetic model and to provide evidence of the mechanisms involved in enhancing these protective effects. We found a potential application of DA9801 on hearing impairment in the STZ-induced diabetic model, demonstrated by reducing the deterioration produced by DM in ABR threshold in response to clicks and normalizing wave I-IV latencies and Pa latencies in AMLR. We also show evidence that these effects might be elicited by inducing NGF related through Nr3c1 and Akt. Therefore, this result suggests that the neuroprotective effects of DA9801 on the auditory damage produced by DM may be affected by NGF increase resulting from Nr3c1 via Akt transformation.
authors: Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 446-701, Republic of Korea ; Department of Oriental Medicinal Materials & Processing, College of Life Sciences, Kyung Hee University, Global Campus, Gyeonggi 446-701, Republic of Korea.
authors: Yeong Ro
authors: 0000-0003-1747-1215
authors: YR
authors: Lee
authors: Department of Oriental Medicinal Materials & Processing, College of Life Sciences, Kyung Hee University, Global Campus, Gyeonggi 446-701, Republic of Korea ; Department of Audiology, Nambu University, Gwangju 506-824, Republic of Korea.
authors: Bin Na
authors: BN
authors: Hong
authors: Department of Oriental Medicinal Materials & Processing, College of Life Sciences, Kyung Hee University, Global Campus, Gyeonggi 446-701, Republic of Korea.
authors: You Ri
authors: YR
authors: Her
authors: Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 446-701, Republic of Korea ; Department of Oriental Medicinal Materials & Processing, College of Life Sciences, Kyung Hee University, Global Campus, Gyeonggi 446-701, Republic of Korea.
authors: Rodrigo
authors: R
authors: Castañeda
authors: Department of Oriental Medicinal Materials & Processing, College of Life Sciences, Kyung Hee University, Global Campus, Gyeonggi 446-701, Republic of Korea.
authors: Hyo Won
authors: HW
authors: Moon
authors: Graduate School of Biotechnology, Kyung Hee University, Global Campus, Gyeonggi 446-701, Republic of Korea ; Department of Oriental Medicinal Materials & Processing, College of Life Sciences, Kyung Hee University, Global Campus, Gyeonggi 446-701, Republic of Korea.
authors: Tong Ho
authors: 0000-0002-4161-6798
authors: TH
authors: Kang