title: Diffuse alveolar hemorrhage secondary to ANCA-associated vasculitis in a patient with Down syndrome.
abstract: Diffuse alveolar hemorrhage (DAH) is a rare disease characterized by dyspnea, cough, hemoptysis, and new alveolar infiltrates. Among the various underlying disorders, vasculitis is believed to play a significant role in the pathogenesis of DAH. Here we report the first case of a patient with Down syndrome who developed DAH secondary to anti-neutrophil cytoplasmic antibody-associated vasculitis. This case highlights the significance of vasculitis as well as pulmonary hypoplasia and vulnerability associated with Down syndrome in the development of DAH.
authors: Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors: Ikumi
authors: I
authors: Hori
authors: Haruna
authors: H
authors: Nakaseko
authors: Michi
authors: M
authors: Kamei
authors: Takayasu
authors: T
authors: Nomura
authors: Naomi
authors: N
authors: Iwata
authors: Yasuhiko
authors: Y
authors: Ito
authors: Shinji
authors: S
authors: Saitoh
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications* / Q000175:diagnosis; D001379:Azathioprine / Q000627:therapeutic use; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008171:Lung Diseases / Q000209:etiology*; D011650:Pulmonary Alveoli / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D001379:Azathioprine
keywords: anti-neutrophil cytoplasmic antibody; diffuse alveolar hemorrhage; glomerulonephritis; trisomy 21; vasculitis