title: Hepatoprotective effect of herb formula KIOM2012H against nonalcoholic fatty liver disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) is a hepatic ailment with a rapidly increasing incidence due to dietary hypernutrition and subsequent obesity. Fatty liver disease can lead to steatohepatitis, fibrosis, cirrhosis, and even cancer, which is associated with various complications. Discovering effective natural materials and herbs can provide alternative and complementary medical treatments to current chemical pharmaceuticals. To develop an effective natural agent for NAFLD, we formulated a combination of four herb mixtures (KIOM2012H) and observed lipid-lowering efficacy. The inhibitory effects of KIOM2012H on free fatty acid-induced lipid accumulation, triglyceride contents, and gene expressions were analyzed in HepG2 cells. Using high fat diet-fed mice, body weight changes, gross liver appearances, hepatic triglyceride contents, and gene expressions were evaluated. KIOM2012H dose-dependently inhibited lipid accumulation and gene expressions involved in lipogenesis and related regulators. Experimental animals also showed a decrease in body weight changes and lipid-associated physiological parameters. This study shows that KIOM2012H has an alleviating effect on fatty acid and lipid accumulation, and therefore can be applied for development of new therapeutic pharmaceuticals for treatment of NAFLD using natural products and herbs.
authors: KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Yuseong-daero 1672, Yuseong-gu, Daejeon 305-811, Korea. uofaz@kiom.re.kr.
authors: Hwayong
authors: H
authors: Park
authors: KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Yuseong-daero 1672, Yuseong-gu, Daejeon 305-811, Korea. hyhhwang@kiom.re.kr.
authors: Youn-Hwan
authors: YH
authors: Hwang
authors: KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Yuseong-daero 1672, Yuseong-gu, Daejeon 305-811, Korea. kite79@kiom.re.kr.
authors: Dong-Gun
authors: DG
authors: Kim
authors: KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Yuseong-daero 1672, Yuseong-gu, Daejeon 305-811, Korea. lovejnj@kiom.re.kr.
authors: Jongwook
authors: J
authors: Jeon
authors: KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Yuseong-daero 1672, Yuseong-gu, Daejeon 305-811, Korea. jyma@kiom.re.kr.
authors: Jin Yeul
authors: JY
authors: Ma
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000187:drug effects; D006801:Humans; D050155:Lipogenesis / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D065626:Non-alcoholic Fatty Liver Disease / Q000188:drug therapy*; D028321:Plant Preparations / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D014280:Triglycerides / Q000378:metabolism
chemical_list: D005230:Fatty Acids, Nonesterified; D028321:Plant Preparations; D014280:Triglycerides