title: Expression of anti-inflammatory mediator lipoxin A4 and inflammation responsive transcriptive factors NF-kappa B in patients with preeclampsia.
abstract: OBJECTIVE
  To evaluate the role of lipoxin A4 (LXA4), NF-kappaB p65 in preeclampsia.
  
  
  METHODS
  LXA4 in blood serum and the lipoxin A4 receptor (ALX-R), NF-kappaB p65 mRNA, protein expressions in placenta-specific tissues were obtained from patients with preeclampsia and normal pregnancy.
  
  
  RESULTS
  Levels of lipoxin A4 in women with mild preeclampsia was significantly high (p < 0.05). There was no significant statistical difference between normal pregnancy and severe preeclampsia (p > 0.05). The mRNA expression of ALX-R was significantly low in women with preeclampsia than in control group (p < 0.01) and mRNA expression of NF- kappaB p65 was significantly high in preeclampsia (p < 0.01). The immunohistochemical staining of NF-kappaB p65 protein was stronger in severe preeclampsia group whereas staining of ALX-R in placental tissue was weaker than in control group (p < 0.01). ALX-R mRNA was negatively correlated with NF-kappaB (p < 0.0001), but there was no correlation between LXA4 and ALX-R mRNA.
  
  
  CONCLUSIONS
  There was an excessive maternal inflammatory response in preeclampsia. LXA4, ALX-R, and NF-kappaB p65 may be involved in the disease process ofpreeclampsia.
authors: L L
authors: LL
authors: Huang
authors: S
authors: S
authors: Su
authors: R
authors: R
authors: Awale
authors: X Y
authors: XY
authors: Zhang
authors: L L
authors: LL
authors: Zhong
authors: H
authors: H
authors: Tang
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000150:complications / Q000235:genetics / Q000378:metabolism*; D044045:Lipoxins / Q000096:biosynthesis / Q000235:genetics*; D010920:Placenta / Q000378:metabolism; D011225:Pre-Eclampsia / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051996:Transcription Factor RelA / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D044045:Lipoxins; D012333:RNA, Messenger; D051996:Transcription Factor RelA; C040527:lipoxin A4