title: The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample.
abstract: BACKGROUND
  Evidences suggest that GAB2 and BDNF genes may be associated with Alzheimer's disease (AD). We aimed to investigate the GAB2 rs2373115 and BDNF rs6265 polymorphisms and the risk of AD in a Brazilian sample.
  
  
  METHODS
  269 AD patients and 114 controls were genotyped with Real-time PCR. Multifactor dimensionality reduction (MDR) was employed to explore the effects of gene-gene interactions.
  
  
  RESULTS
  GAB2 and BDNF were not associated with AD in our sample. Nevertheless BDNF Val allele (rs6265) presented a synergic association with the APOE ε4 allele. A multiple logistic regression demonstrated that the APOE ε4 allele and years of education were the best predictors for AD. In ε4 non-carriers sex, education and hypertension were independently correlated with AD, while in ε4 carriers we did not observe any association. The findings were further confirmed by bootstrapping method.
  
  
  CONCLUSIONS
  Our data suggest that the interaction of BDNF and APOE has significant effect on AD. Moreover in absence of ε4, female sex, low level of education and hypertension are independently associated with AD. Interventions aimed to prevent AD should focus on these factors and also taking into account the APOE alleles.
authors: INCT de Medicina Molecular,Faculdade de Medicina,Universidade Federal de Minas Gerais,Belo Horizonte,30130-100Brazil.
authors: Renalice Neves
authors: RN
authors: Vieira
authors: Department of Internal Medicine,Universidade Federal de Minas Gerais,Belo Horizonte 30130-100,Brazil.
authors: Joalce Dornelas
authors: JD
authors: Magalhães
authors: Department of Internal Medicine,Universidade Federal de Minas Gerais,Belo Horizonte 30130-100,Brazil.
authors: Jemima
authors: J
authors: Sant'Anna
authors: Academy Medical,Universidade Federal de Minas Gerais,Belo Horizonte 30130-100,Brazil.
authors: Mateus Massao
authors: MM
authors: Moriguti
authors: INCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100 Brazil.
authors: Jonas Jardim
authors: JJ
authors: de Paula
authors: Marco Túlio Gualberto
authors: MT
authors: Cintra
authors: INCT de Medicina Molecular,Faculdade de Medicina,Universidade Federal de Minas Gerais,Belo Horizonte,30130-100Brazil.
authors: Débora Marques
authors: DM
authors: de Miranda
authors: INCT de Medicina Molecular,Faculdade de Medicina,Universidade Federal de Minas Gerais,Belo Horizonte,30130-100Brazil.
authors: Luiz
authors: L
authors: De Marco
authors: INCT de Medicina Molecular,Faculdade de Medicina,Universidade Federal de Minas Gerais,Belo Horizonte,30130-100Brazil.
authors: Edgar Nunes
authors: EN
authors: de Moraes
authors: INCT de Medicina Molecular,Faculdade de Medicina,Universidade Federal de Minas Gerais,Belo Horizonte,30130-100Brazil.
authors: Marco Aurélio
authors: MA
authors: Romano-Silva
authors: IINCT de Medicina Molecular, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, 30130-100 Brazil; Department of Internal Medicine.
authors: Maria Aparecida Camargos
authors: MA
authors: Bicalho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4; D019208:Brain-Derived Neurotrophic Factor
keywords: APOE; Alzheimer’s disease; BDNF; GAB2; risk factors