title: An investigation of the association of the H558R polymorphism of the SCN5A gene with idiopathic cardiac conduction disorders.
abstract: OBJECTIVE
  The aim of this study was to investigate the predictive value of the rs1805124 polymorphism of the SCN5A gene with regard to idiopathic cardiac conduction disorders.
  
  
  RESULTS
  The AG genotype frequency was significantly higher in patients with an atrioventricular block (61,2%±6,0%) compared with healthy control subjects (34,8%±2,3%), p<0.0001. The AG genotype frequencies among patients with only idiopathic complete right bundle-branch block (CRBBB) (54,2%±5,5%) and those with both CLBBB and LAH (50%±5,1) were significantly higher than in the control group (34,8%±2,3%), p<0.005.
  
  
  CONCLUSIONS
  The AG genotype of the H558R (rs1805124) polymorphism of the SCN5A gene is a genetic predictor of idiopathic disorders of atrioventricular and intraventricular conduction.
authors: 1 Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky of the Ministry of Healthcare of the Russian Federation , Krasnoyarsk, Russian Federation.
authors: Svetlana Y
authors: SY
authors: Nikulina
authors: 1 Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky of the Ministry of Healthcare of the Russian Federation , Krasnoyarsk, Russian Federation.
authors: Anna A
authors: AA
authors: Chernova
authors: 1 Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky of the Ministry of Healthcare of the Russian Federation , Krasnoyarsk, Russian Federation.
authors: Vladimir A
authors: VA
authors: Shulman
authors: 2 Therapy and Preventive Medicine Research Institute of the Siberian Branch of the Russian Academy of Medical Sciences , Novosibirsk, Russian Federation.
authors: Vladimir N
authors: VN
authors: Maksimov
authors: 1 Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky of the Ministry of Healthcare of the Russian Federation , Krasnoyarsk, Russian Federation.
authors: Oksana A
authors: OA
authors: Gavrilyuk
authors: 1 Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky of the Ministry of Healthcare of the Russian Federation , Krasnoyarsk, Russian Federation.
authors: Svetlana S
authors: SS
authors: Tretyakova
authors: 3 Krasnoyarsk Interdistrict Clinical Hospital No. 20 named after I.S. Berzon , Krasnoyarsk, Russian Federation.
authors: Olga V
authors: OV
authors: Marilovceva
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000235:genetics*; D053840:Brugada Syndrome; D002037:Bundle-Branch Block / Q000235:genetics; D000075224:Cardiac Conduction System Disease; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006329:Heart Conduction System / Q000002:abnormalities*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D062554:NAV1.5 Voltage-Gated Sodium Channel / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D055815:Young Adult
chemical_list: D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human