title: Nanomedicine in veterinary oncology.
abstract: Nanomedicine is an interdisciplinary field that combines medicine, engineering, chemistry, biology and material sciences to improve disease management and can be especially valuable in oncology. Nanoparticle-based agents that possess functions such as tumor targeting, imaging and therapy are currently under intensive investigation. This review introduces the basic concept of nanomedicine and the classification of nanoparticles. Because of their favorable pharmacokinetics, tumor targeting properties, and resulting superior efficacy and toxicity profiles, nanoparticle-based agents can overcome several limitations associated with conventional diagnostic and therapeutic protocols in veterinary oncology. The two most important tumor targeting mechanisms (passive and active tumor targeting) and their dominating factors (i.e. shape, charge, size and nanoparticle surface display) are discussed. The review summarizes published clinical and preclinical studies that utilize different nanoformulations in veterinary oncology, as well as the application of nanoparticles for cancer diagnosis and imaging. The toxicology of various nanoformulations is also considered. Given the benefits of nanoformulations demonstrated in human medicine, nanoformulated drugs are likely to gain more traction in veterinary oncology.
authors: Department of Internal Medicine, School of Medicine, University of California-Davis, Sacramento, CA 95817, USA. Electronic address: tylin@ucdavis.edu.
authors: Tzu-Yin
authors: TY
authors: Lin
authors: Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA.
authors: Carlos O
authors: CO
authors: Rodriguez
authors: Department of Biochemistry and Molecular Biology, School of medicine, University of California-Davis, Sacramento, CA 95817, USA.
authors: Yuanpei
authors: Y
authors: Li
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016503:Drug Delivery Systems; D006801:Humans; D050997:Nanomedicine / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000188:drug therapy*; D014730:Veterinary Medicine / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents
keywords: Chemotherapy; Drug delivery; Nanomedicine; Nanoparticles; Oncology; Veterinary