title: Role of F-18 FDG PET/CT in assessing IgG4-related disease with inflammation of head and neck glands.
abstract: OBJECTIVE
  The aim of the current study was to evaluate the utility of F-18-fluoro-2-deoxy-D-glucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in assessing patients diagnosed with immunoglobulin G4 (IgG4)-related disease (IgG4-RD) with inflammation of the head and neck glands.
  
  
  METHODS
  We reviewed the records of 17 patients (16 men and 1 woman) with IgG4-RD exhibiting inflammation of the head and neck glands (lacrimal or salivary glands; LSG) who were diagnosed by excisional biopsy of the LSG. F-18 FDG PET/CT images were retrospectively evaluated for locations of high FDG accumulation, and the maximum standardized uptake value (SUVmax) of each lesion was calculated.
  
  
  RESULTS
  In 15 of 17 patients (88 %), FDG accumulation was observed in organs outside of the biopsied LSG. High FDG accumulation was most frequently seen in the lymph node (71 %), followed by the non-biopsied LSG (41 %). FDG accumulation was also found in other typically affected organs including the prostate and retroperitoneum (18 %), kidney and lung (12 %), and pancreas (1 %). FDG accumulation was most commonly observed in two lesions outside of the biopsied site (41 %).
  
  
  CONCLUSIONS
  Detection of the multi-organ involvement before treatment is important for patients with IgG4-RD. F-18 FDG PET/CT is an effective tool for assessing the location of extra-LSG lesions in patients with IgG4-RD with LSG inflammation.
authors: Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Hospital, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan, azusa-n@sea.sannet.ne.jp.
authors: Azusa
authors: A
authors: Tokue
authors: Tetsuya
authors: T
authors: Higuchi
authors: Yukiko
authors: Y
authors: Arisaka
authors: Takahito
authors: T
authors: Nakajima
authors: Hiroyuki
authors: H
authors: Tokue
authors: Yoshito
authors: Y
authors: Tsushima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000069281:Autoimmune Hypophysitis / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007765:Lacrimal Apparatus / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012469:Salivary Glands / Q000000981:diagnostic imaging; D012796:Sialography / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18