title: Factors influencing the functional significance in intermediate coronary stenosis.
abstract: OBJECTIVE
  To analyze the influencing factors of the functional significance determined by fractional flow reserve (FFR) in intermediate coronary artery stenosis.
  
  
  METHODS
  The study enrolled 143 patients with 203 intermediate coronary lesions. Pressure-derived FFR of these lesions was gained at maximal hyperemia induced by intravenous adenosine infusion. An FFR < 0.80 was considered as abnormal functional significance. Anatomic parameters at the lesion sites were obtained by off-line quantitative coronary angiography analysis (QCA). The predictive value of the demographic characteristics and anatomic parameters for FFR in these intermediate lesions was assessed using multiple linear and binary logistic regression analysis.
  
  
  RESULTS
  Overall, FFR < 0.8 was found in 70 (34%) of the total 203 intermediate coronary lesions. FFR values were positively correlated with QCA-measured minimum lumen diameters (MLD, r = 0.372, P = 0.000) and the reference vessel diameters (RVD, r = 0.217, P = 0.002) were negatively correlated with percent area stenosis (AS, r = -0.251, P = 0.000) and percent diameter stenosis (DS, r = -0.210, P = 0.000). Age, MLD and the lesion location in different coronary arteries were the independent determinants of FFR < 0.8.
  
  
  CONCLUSIONS
  MLD can predict the functional significance of intermediate coronary stenosis, while age and the lesion location in different coronary arteries should be taken into account as important influencing factors of FFR values.
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Li-Jie
authors: LJ
authors: Sun
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Gui-Song
authors: GS
authors: Wang
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Ming
authors: M
authors: Cui
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Li-Jun
authors: LJ
authors: Guo
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Yong-Zhen
authors: YZ
authors: Zhang
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Fu-Chun
authors: FC
authors: Zhang
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Jie
authors: J
authors: Niu
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Jiang-Li
authors: JL
authors: Han
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Wei-Xian
authors: WX
authors: Xu
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Dan
authors: D
authors: Zhu
authors: Department of Cardiology, Peking University Third Hospital, 49 North Huayuan Road, Haidian District, Beijing100191, China.
authors: Wei
authors: W
authors: Gao
keywords: Fractional flow reserve; Influencing factors; Intermediate coronary lesion; Quantitative coronary angiography