title: Identification of a quorum sensing pheromone posttranslationally farnesylated at the internal tryptophan residue from Bacillus subtilis subsp. natto.
abstract: Bacillus subtilis subsp. natto produces poly-γ-glutamic acid under the control of quorum sensing. We identified ComXnatto pheromone as the quorum-sensing pheromone with an amino acid sequence of Lys-Trp-Pro-Pro-Ile-Glu and the tryptophan residue posttranslationally modified by a farnesyl group. ComXnatto pheromone is unique in the sense that the 5th tryptophan residue from the C-terminal is farnesylated.
authors: a Graduate School of Bioscience and Biotechnology , Chubu University , Kasugai , Japan.
authors: Shunsuke
authors: S
authors: Hayashi
authors: Syohei
authors: S
authors: Usami
authors: Yuta
authors: Y
authors: Nakamura
authors: Koki
authors: K
authors: Ozaki
authors: Masahiro
authors: M
authors: Okada
mesh_terms: D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010675:Pheromones / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011099:Polyglutamic Acid / Q000096:biosynthesis; D054876:Prenylation; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D053038:Quorum Sensing / Q000235:genetics*; D014364:Tryptophan / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D010675:Pheromones; D011099:Polyglutamic Acid; D014364:Tryptophan
keywords: Bacillus subtilis; isoprenylation; posttranslational modification; quorum sensing; tryptophan