title: [Clinical detection and significance of plasma IL-37 in patients with active pulmonary tuberculosis].
abstract: OBJECTIVE
  To investigate the level of plasma interleukin 37 (IL-37) and explore the clinical significance of IL-37 in patients with active pulmonary tuberculosis (ATB).
  
  
  METHODS
  ELISA was used to detect the level of plasma IL-37 from 30 patients with ATB, 15 patients who had been treated for ATB, and 21 healthy volunteers as controls.
  
  
  RESULTS
  The level of plasma IL-37 in patients with ATB was significantly higher than that in healthy controls. The monitoring on the 15 patients showed that plasma IL-37 was reduced after treatment for ATB. The level of plasma IL-37 in patients with anti-Mycobecterium tuberculosis antibody positive or sputum smear positive were higher than that in patients with anti-Mycobecterium tuberculosis antibody negative or sputum smear negative for Mycobecterium tuberculosis, and the level was negatively correlated with the number of white blood cells in peripheral blood.
  
  
  CONCLUSIONS
  The patients with ATB present with significantly increased level of plasma IL-37, which might be an indicator of curative effect in ATB.
authors: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan 523808; Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, Dongguan 523808, China.
authors: Junai
authors: J
authors: Zhang
authors: Sixth People's Hospital of Dongguan City, Dongguan 523122, China.
authors: Ganbin
authors: G
authors: Liu
authors: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan 523808; Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, Dongguan 523808, China.
authors: Jincheng
authors: J
authors: Zeng
authors: Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, Dongguan 523808, China.
authors: Wandang
authors: W
authors: Wang
authors: Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, Dongguan 523808, China.
authors: Wenyu
authors: W
authors: Xiang
authors: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan 523808, China.
authors: Bin
authors: B
authors: Kong
authors: Sixth People's Hospital of Dongguan City, Dongguan 523122, China.
authors: Lailong
authors: L
authors: Yi
authors: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan 523808; Department of Clinical Immunology, Institute of Laboratory Medicine, Guangdong Medical College, Dongguan 523808, China.
authors: Junfa
authors: J
authors: Xu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000502:physiology; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000382:microbiology
chemical_list: C508587:IL37 protein, human; D007375:Interleukin-1