title: Synthesis, characterization, crystal structure and antimicrobial activity of copper(II) complexes with the Schiff base derived from 2-hydroxy-4-methoxybenzaldehyde.
abstract: A novel Schiff base, ethyl 4-[(E)-(2-hydroxy-4-methoxyphenyl)methylene-amino]benzoate (HL), was prepared and structurally characterized on the basis of elemental analyses, (1)H NMR, (13)C NMR, UV-Vis and IR spectral data. Six new copper(II) complexes, [Cu(L)(NO3)(H2O)2] (1), [Cu(L)2] (2), [Cu(L)(OAc)] (3), [Cu2 (L)2Cl2(H2O)4] (4), [Cu(L)(ClO4)(H2O)] (5) and [Cu2(L2S)(ClO4)(H2O)]ClO4·H2O (6) have been synthesized. The characterization of the newly formed compounds was done by IR, UV-Vis, EPR, FAB mass spectroscopy, elemental and thermal analysis, magnetic susceptibility measurements and molar electric conductivity. The crystal structures of Schiff base and the complex [Cu2(L2S)(ClO4)(H2O)]ClO4·H2O (6) have been determined by single crystal X-ray diffraction studies. Both copper atoms display a distorted octahedral coordination type [O4NS]. This coordination is ensured by three phenol oxygen, two of which being related to the µ-oxo-bridge, the nitrogen atoms of the azomethine group and the sulfur atoms that come from the polydentate ligand. The in vitro antimicrobial activity against Escherichia coli ATCC 25922, Salmonella enteritidis, Staphylococcus aureus ATCC 25923, Enterococcus and Candida albicans strains was studied and compared with that of free ligand. The complexes 1, 2, 5 showed a better antimicrobial activity than the Schiff base against the tested microorganisms.
authors: Inorganic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 6 Traian Vuia Street, 020956 Bucharest, Romania. elenaandmihaela@yahoo.com.
authors: Elena
authors: E
authors: Pahonțu
authors: Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Rosie Street, 020462 Bucharest, Romania. ilies_diana@hotmail.com.|Organic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", 6 Traian Vuia Street, 020956 Bucharest, Romania. ilies_diana@hotmail.com.
authors: Diana-Carolina
authors: DC
authors: Ilieș
authors: Institute of Macromolecular Chemistry "Petru Poni", 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania. shova@icmpp.ro.
authors: Sergiu
authors: S
authors: Shova
authors: Organic Chemistry Department, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Street, 050663 Bucharest, Romania. c.paraschivescu@gmail.com.
authors: Codruța
authors: C
authors: Paraschivescu
authors: Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Rosie Street, 020462 Bucharest, Romania. e_m_badea@yahoo.com.
authors: Mihaela
authors: M
authors: Badea
authors: Coordination Chemistry Department, Moldova State University, 60 Mateevici Street, 2009 Chisinau, Moldova. dociu1946@yahoo.com.
authors: Aurelian
authors: A
authors: Gulea
authors: Inorganic Chemistry Department, Faculty of Chemistry, University of Bucharest, 23 Dumbrava Rosie Street, 020462 Bucharest, Romania. t_rosu0101@yahoo.com.
authors: Tudor
authors: T
authors: Roșu
mesh_terms: D062365:Aminobenzoates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001547:Benzaldehydes / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D016983:Enterococcus / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D012477:Salmonella enteritidis / Q000187:drug effects; D012545:Schiff Bases / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D062365:Aminobenzoates; D000890:Anti-Infective Agents; D001547:Benzaldehydes; D056831:Coordination Complexes; D012545:Schiff Bases; C118297:2-hydroxy-4-methoxybenzaldehyde; D003300:Copper