title: SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations.
abstract: Ebp2 is an assembly factor of the 60S ribosomal subunit in yeast. We demonstrate that overexpression of SMY2 or SYH1 partially suppresses defects in growth and ribosome biogenesis of ebp2 mutants, and that smy2Δ and syh1Δ exhibit synthetic growth defects with the ebp2 allele. These results suggest that Smy2 and Syh1 may be involved in ribosome biogenesis in relation to Ebp2.
authors: a Department of Biofunctional Science and Technology, Graduate School of Biosphere Science , Hiroshima University , Higashi-Hiroshima , Japan.
authors: Akira
authors: A
authors: Okano
authors: Kun
authors: K
authors: Wan
authors: Kazuhiro
authors: K
authors: Kanda
authors: Yukari
authors: Y
authors: Yabuki
authors: Kouichi
authors: K
authors: Funato
authors: Keiko
authors: K
authors: Mizuta
mesh_terms: D002352:Carrier Proteins / Q000235:genetics*; D009154:Mutation; D012335:RNA, Ribosomal / Q000235:genetics; D012269:Ribosomal Proteins; D054683:Ribosome Subunits, Large, Eukaryotic / Q000235:genetics; D012270:Ribosomes / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D033921:Vesicular Transport Proteins / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; C499008:EBP2 protein, S cerevisiae; D012335:RNA, Ribosomal; D012269:Ribosomal Proteins; C083574:SMY2 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins
keywords: EBP2; SMY2; SYH1; ribosome biogenesis