title: A Palladium(II)-Catalyzed C-H Activation Cascade Sequence for Polyheterocycle Formation.
abstract: Polyheterocycles are found in many natural products and are useful moieties in functional materials and drug design. As part of a program towards the synthesis of Stemona alkaloids, a novel palladium(II)-catalyzed C-H activation strategy for the construction of such systems has been developed. Starting from simple 1,3-dienyl-substituted heterocycles, a large range of polycyclic systems containing pyrrole, indole, furan and thiophene moieties can be synthesized in a single step.
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS (UK) http://www.chm.bris.ac.uk/org/bmilburn/index2.htm.
authors: Stephen P
authors: SP
authors: Cooper
authors: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS (UK) http://www.chm.bris.ac.uk/org/bmilburn/index2.htm. k.booker-milburn@bristol.ac.uk.
authors: Kevin I
authors: KI
authors: Booker-Milburn
mesh_terms: D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D008968:Molecular Conformation; D010165:Palladium / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D010165:Palladium; D002244:Carbon; D006859:Hydrogen
keywords: CH activation; domino reactions; heterocycles; homogeneous catalysis; palladium