title: Detection of drug resistance in Mycobacterium tuberculosis: Methods, principles and applications.
abstract: The growing emergence of multidrug resistant tuberculosis (MDR-TB) strains is obstructing efforts for the control and management of TB. Proper management of MDR-TB relies on early recognition of drug resistance followed by timely treatment initiation. Several diagnostic methods, both phenotypic and molecular, have been developed in last few years for rapid identification of drug resistant (DR)-TB. Revised national tuberculosis control programmes (RNTPs) may find it tough to choose from the puzzling variety of rapid tests. Here, we present an outline of the available methods, discussing their basis, advantages and deficiencies.
authors: Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
authors: Anamika
authors: A
authors: Gupta
authors: Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. Electronic address: shampa_anupurba@yahoo.co.in.
authors: Shampa
authors: S
authors: Anupurba
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D042241:Early Diagnosis; D061345:Early Medical Intervention; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000145:classification / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000502:physiology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents
keywords: Drug resistant TB; Drug susceptibility testing; Tuberculosis; Turnaround time