title: Homeostatic control of biological membranes by dedicated lipid and membrane packing sensors.
abstract: Biological membranes are dynamic and complex assemblies of lipids and proteins. Eukaryotic lipidomes encompass hundreds of distinct lipid species and we have only begun to understand their role and function. This review focuses on recent advances in the field of lipid sensors and discusses methodical approaches to identify and characterize putative sensor domains. We elaborate on the role of integral and conditionally membrane-associated sensor proteins, their molecular mechanisms, and identify open questions in the emerging field of membrane homeostasis.
authors: Kristina
authors: K
authors: Puth
authors: Harald F
authors: HF
authors: Hofbauer
authors: James P
authors: JP
authors: Sáenz
authors: Robert
authors: R
authors: Ernst
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008563:Membrane Lipids; D008565:Membrane Proteins