title: Erdheim-Chester disease and knee pain in a dialysis patient.
abstract: Erdheim-Chester disease is a rare inflammatory condition characterized by a non-Langerhans histiocytic infiltration, involving the skeleton, nervous system, viscera, retroperitoneum and elsewhere. The aetiology is unknown. Positron emission tomography shows areas of involvement. We managed a dialysis patient with knee pain; a bone marrow specimen showed typical CD68 positive, but CD1a negative cells. We initiated interferon-α therapy although other options remain open. In our patient, the simultaneous presence of secondary hyperparathyroidism with tumorous calcifications provided an interesting additional differential diagnostic possibility regarding skeletal pain.
authors: Department of Nephrology and Intensive Care Medicine, Virchow Klinikum , Charité Medical Faculty , Berlin , Germany.
authors: Sibylle
authors: S
authors: Rademacher
authors: Department of Pathology , Charité Medical Faculty , Berlin , Germany.
authors: Joannis
authors: J
authors: Anagnostopoulos
authors: Experimental and Clinical Research Center , Max-Delbrück Center for Molecular Medicine and Charité Medical Faculty , Berlin , Germany.
authors: Friedrich C
authors: FC
authors: Luft
authors: Department of Nephrology and Intensive Care Medicine, Virchow Klinikum , Charité Medical Faculty , Berlin , Germany ; Experimental and Clinical Research Center , Max-Delbrück Center for Molecular Medicine and Charité Medical Faculty , Berlin , Germany.
authors: Ralph
authors: R
authors: Kettritz
keywords: Erdheim–Chester; calcification; dialysis; histiocytosis