title: Prognostic factors and survival rate of osteosarcoma: A single-institution study.
abstract: OBJECTIVE
  Osteosarcoma is a highly malignant primary bone tumor. The study aim to evaluate the prognostic factors influencing the survival rate in our center.
  
  
  METHODS
  This was a retrospective cohort study of all patients treated between January 2005 and December 2010.
  
  
  RESULTS
  We included 163 patients with an age range of 6-59 years (median = 19). The median follow-up was 47 months (range 36-84). The overall survival in patients who completed chemotherapy and surgery (n = 117) was 72% at 2 years and 44% at 5 years. Histologically, 99 (85%) had osteoblastic, 6 (5%) had chondroblastic and 3 (2.5%) had telangiectatic osteosarcoma. Limb salvage surgery was performed in 80 (49%) and 41 (25%) underwent amputation. However, 46 patients (28%) underwent no surgical intervention and incomplete chemotherapy. In total, 38/79 patients had a good chemotherapy response. There was a significantly better survival rate for limb salvage versus amputation. Independent prognostic factors for survival are compliance to treatment and presence of lung metastasis.
  
  
  CONCLUSIONS
  The overall survival of osteosarcoma patients was influenced by the presence of pulmonary metastases and compliance to treatment. Histological subtype, different chemotherapy regimens and histological necrosis after chemotherapy did not significantly influence survival. The patients who did not complete treatment had significantly poorer survival.
authors: Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Wan Ismail
authors: WI
authors: Faisham
authors: Reconstructive Sciences Unit, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Arman Zaharil
authors: AZ
authors: Mat Saad
authors: Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Laith N
authors: LN
authors: Alsaigh
authors: Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Mat Z
authors: MZ
authors: Nor Azman
authors: Department of Community Medicine, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Musa
authors: M
authors: Kamarul Imran
authors: Department of Radiation Therapy and Oncology, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Biswa M
authors: BM
authors: Biswal
authors: Department of Radiation Therapy and Oncology, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Venkata Mk
authors: VM
authors: Bhavaraju
authors: Department of Pathology, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Md Salleh
authors: MS
authors: Salzihan
authors: Department of Pathology, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Jaafar
authors: J
authors: Hasnan
authors: Department of Radiology, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Aziz M
authors: AM
authors: Ezane
authors: Department of Pediatric (Oncology), Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Nasir
authors: N
authors: Ariffin
authors: Department of Pediatric (Oncology), Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Mohamad
authors: M
authors: Norsarwany
authors: Cardiothoracic Unit, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Mohamad G
authors: MG
authors: Ziyadi
authors: Reconstructive Sciences Unit, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Wan Sulaiman
authors: WS
authors: Wan Azman
authors: Reconstructive Sciences Unit, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Ahmad Sukari
authors: AS
authors: Halim
authors: Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
authors: Wan
authors: W
authors: Zulmi
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000401:mortality* / Q000473:pathology; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
keywords: extremity; osteosarcoma; prognosis; survival analysis