title: Reproductive outcome of a case with familial balanced translocation t(3;6): implications for genetic counseling.
abstract: Although it is known that parental carriers of structural chromosomal rearrangements are associated with recurrent pregnancy loss, subsequent natural pregnancies remain possible. We examined the reproductive outcome of a familial balanced translocation with t(3;6)(q12;q27). Karyotyping of the proband revealed 46,XY chromosomes with the balanced translocation t(3;6). The first 2 pregnancies resulted in spontaneous abortions. Based on the proband karyotype, his father and half-brother were subjected to cytogenetic analysis, and both showed 46,XY, t(3;6)(q12;q27). After genetic counseling, the proband chose to continue the pregnancy. During the third pregnancy, the subject gave birth to a normal male infant. For parental carriers with balanced chromosomal translocations, natural pregnancy should be considered during genetic counseling.
authors: Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, Jilin Province, China.
authors: H-G
authors: HG
authors: Zhang
authors: Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, Jilin Province, China.
authors: X-Y
authors: XY
authors: Liu
authors: Department of Urology, China-Japan Friendship Hospital, Jilin University, Changchun, Jilin Province, China.
authors: Y
authors: Y
authors: Hou
authors: Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, Jilin Province, China.
authors: S
authors: S
authors: Chen
authors: Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, Jilin Province, China.
authors: S
authors: S
authors: Deng
authors: Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, Jilin Province, China lrz410@126.com.
authors: R-Z
authors: RZ
authors: Liu
mesh_terms: D000026:Abortion, Habitual; D000328:Adult; D002871:Chromosome Banding; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005192:Family Health; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007231:Infant, Newborn; D059785:Karyotype; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D011256:Pregnancy Outcome; D014178:Translocation, Genetic