title: Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.
abstract: Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for OA that could serve as building blocks for describing OA and defining OA phenotypes, in short to provide unifying disease concepts for a heterogeneous disorder; and (2) To stimulate establishment of ROAD (Risk of OA Development) and ROAP (Risk of OA Progression) tools analogous to the FRAX™ instrument for predicting risk of fracture in osteoporosis; and (3) To stimulate formulation of tools for identifying disease in its early preradiographic and/or molecular stages - REDI (Reliable Early Disease Identification). Consensus around more sensitive and specific diagnostic criteria for OA could spur development of disease modifying therapies for this entity that has proved so recalcitrant to date. We fully acknowledge that as we move forward, we expect to develop more sophisticated definitions, terminology and tools.
authors: Duke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA. Electronic address: vbk@duke.edu.
authors: V B
authors: VB
authors: Kraus
authors: Grupo de Proteomica, ProteoRed/ISCIII, Servicio de Reumatologia, Instituto de Investigación Biomedica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), As Xubias, 15006, A Coruña, Spain.
authors: F J
authors: FJ
authors: Blanco
authors: Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston University, MA, USA.
authors: M
authors: M
authors: Englund
authors: Nordic Bioscience, Herlev, Denmark.
authors: M A
authors: MA
authors: Karsdal
authors: Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden; Research Unit for Musculoskeletal Function and Physiotherapy, and Department of Orthopedics and Traumatology, University of Southern Denmark, Odense, Denmark.
authors: L S
authors: LS
authors: Lohmander
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards*; D018450:Disease Progression; D006293:Health Promotion; D006801:Humans; D010003:Osteoarthritis / Q000145:classification* / Q000175:diagnosis; D058866:Osteoporotic Fractures / Q000517:prevention & control; D063868:Patient Outcome Assessment; D018570:Risk Assessment; D009626:Terminology as Topic
keywords: Anatomy; Biomarkers; Criteria; Definition; Osteoarthritis; Physiology