title: Polymorphisms of uric transporter proteins in the pathogenesis of gout in a Chinese Han population.
abstract: In this study, we analyzed single nucleotide polymorphisms (SNP) in urate transporter genes to examine the pathogenesis of gout. We conducted a 1:1-matched case-control study that included 110 patients with acute gout attacks as the patient group and 110 healthy age- and gender-matched subjects as the control group. Clinical parameters were recorded and blood biochemistry tests were conducted for both groups. Multivariate logistic regression analysis was used to analyze the data. Hyperuricemia, hypercholesterolemia, and hypertriglyceridemia were found to be the main risk factors for the onset of gout, with relative risks of 29.2 (P < 0.001), 25.5 (P = 0.003), and 11.2 (P < 0.001). For all detected SNP, rs2231142, located in ABCG2, showed the largest frequency differences for the G/G, G/T, and T/T genotypes between groups: the distribution of these genotypes in the case group was 22, 49, and 26 individuals, respectively, and was 54, 38, and 9 individuals, respectively, in the control group. There was a statistically significant difference between the 2 groups (P < 0.001) and the odds ratio was 7.091 (95% confidence interval = 2.867-17.541). Other SNPs (rs1165196, rs1165205, rs1183201, rs17300741, rs2078267, rs2242206, rs3733591, and rs9358856) showed no significant difference between the groups (P > 0.05). The risk factors of gout were hyperuricemia, hypercholesterolemia, hypertriglyceridemia, and the T/T genotype of the rs2231142 locus in the ABCG2 gene; expression of the G/G genotype may be a protective factor against gout development.
authors: Department of Rheumatology and Immunology, Shanghai Hospital of Second Military Medical University, Shanghai, China.
authors: W
authors: W
authors: Wan
authors: Department of Rheumatology and Immunology, Shanghai Hospital of Second Military Medical University, Shanghai, China.
authors: X
authors: X
authors: Xu
authors: Department of Rheumatology and Immunology, Shanghai Hospital of Second Military Medical University, Shanghai, China dongbaozhao@126.com.
authors: D B
authors: DB
authors: Zhao
authors: Department of Rheumatology and Immunology, Shanghai Hospital of Second Military Medical University, Shanghai, China.
authors: Y F
authors: YF
authors: Pang
authors: Department of Rheumatology and Immunology, Shanghai Hospital of Second Military Medical University, Shanghai, China.
authors: Y X
authors: YX
authors: Wang
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006073:Gout / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D015228:Hypertriglyceridemia / Q000150:complications; D033461:Hyperuricemia / Q000150:complications; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D027361:Organic Anion Transporters / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
chemical_list: C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D009363:Neoplasm Proteins; D027361:Organic Anion Transporters; C103862:urate transporter