title: A fluorescent chemosensor for Hg(2+) and Cd(2+) ions in aqueous medium under physiological pH and its applications in imaging living cells.
abstract: A new BODIPY derivative with 2,2'-(ethane-1,2-diylbis(oxy))bis(N,N-bis(pyridine-2-ylmethyl)aniline unit as the metal receptor has been designed and synthesized. The dye selectively detects either Cd(2+) or Hg(2+) ions in the presence of hosts of other biologically important and environmentally relevant metal ions in aqueous medium at physiological pH. Binding of metal ions causes a change in the emission behavior of the dye from weakly fluorescent to highly fluorescent. Confocal microscopic experiments validate that the dye can be used to identify changes in either Hg(2+) or Cd(2+) levels in living cells.
authors: †Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.
authors: Shubhra B
authors: SB
authors: Maity
authors: †Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.
authors: Saikat
authors: S
authors: Banerjee
authors: ‡Department of Chemistry, Korea University, Seoul 136-701, Korea.
authors: Kyoung
authors: K
authors: Sunwoo
authors: ‡Department of Chemistry, Korea University, Seoul 136-701, Korea.
authors: Jong Seung
authors: JS
authors: Kim
authors: †Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.
authors: Parimal K
authors: PK
authors: Bharadwaj
mesh_terms: D002104:Cadmium / Q000032:analysis*; D002478:Cells, Cultured; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000032:analysis; D008628:Mercury / Q000032:analysis*; D008958:Models, Molecular; D015394:Molecular Structure; D014867:Water / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D007477:Ions; D002104:Cadmium; D014867:Water; D008628:Mercury