title: 1,5-Anhydroglucitol: a new predictor of neonatal birth weight in diabetic pregnancies.
abstract: OBJECTIVE
  To determine whether 1,5-anhydroglucitol is predictive of neonatal birth weight.
  
  
  METHODS
  A retrospective cohort study including 85 pregnancies complicated by diabetes (Type 1=37, Type 2=24, gestational=24). Women had simultaneous hemoglobin A1c and 1,5-anhydroglucitol measurements every 4-8 weeks throughout pregnancy until delivery. Neonatal birth weight was evaluated by standardized z-scores. Linear regression analysis was performed to determine an association of 1,5-anhydroglucitol with neonatal birth weight z-score.
  
  
  RESULTS
  Type 1 diabetic patients had the lowest mean 1,5-anhydroglucitol of 3.5mcg/mL (SD=1.6mcg/mL) and highest mean hemoglobin A1c of 6.5% (SD=0.74%) compared to gestational diabetic patients who had the highest mean 1,5-anhydroglucitol of 6.7mcg/mL (SD=3.8mcg/mL) and lowest mean hemoglobin A1c of 6.0% (SD=0.94%). Mean 1,5-anhydroglucitol values were significantly different between diabetes types (p<0.01). Mean neonatal birth weight was above population averages for all diabetes classifications, although mean birth weight z-scores did not differ significantly between diabetic types (p=0.38). Multivariate linear regression showed a negative association between log-transformed 1,5-anhydroglucitol and birth weight (coefficient -0.82, 95% CI -1.19, -0.46).
  
  
  CONCLUSIONS
  In pregnancies complicated by diabetes, low 1,5-anhydroglucitol was associated with increased neonatal birth weight. 1,5-Anhydroglucitol may be useful in the assessment of glycemic control in pregnancy in addition to A1c.
authors: Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA. Electronic address: delaneys@uw.edu.
authors: Shani S
authors: SS
authors: Delaney
authors: Department of Biostatistics, University of Washington, Seattle, WA, USA.
authors: R Yates
authors: RY
authors: Coley
authors: Department of Obstetrics & Gynecology, University of Washington, Seattle, WA, USA.
authors: Zane
authors: Z
authors: Brown
mesh_terms: D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D015331:Cohort Studies; D003847:Deoxyglucose; D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood; D005260:Female; D005865:Gestational Age; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D003847:Deoxyglucose; D006442:Glycated Hemoglobin; C006584:1,5-anhydroglucitol
keywords: 1,5-Anhydroglucitol; Diabetes; Neonatal birth weight; Pregnancy