title: Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population.
abstract: In this study, we investigated the association between a RECQL genetic polymorphism and osteosarcoma in a Chinese population. We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls. We found that the CC genotype was more frequent in the osteosarcoma group compared to the control group (P = 0.011). We also found that the C allele was more common in osteosarcoma patients than that in control subjects (P = 0.004). Our results suggested that the RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population.
authors: Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical College, Weihui, China dongy_zhen@yeah.net.
authors: Y Z
authors: YZ
authors: Dong
authors: Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical College, Weihui, China.
authors: Y X
authors: YX
authors: Huang
authors: Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical College, Weihui, China.
authors: T
authors: T
authors: Lu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D060005:Genotyping Techniques; D006239:Haplotypes; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D053484:RecQ Helicases / Q000235:genetics*; D055815:Young Adult
chemical_list: C506732:RECQL5 protein, human; D053484:RecQ Helicases