title: Dendrimer-nanoparticle conjugates in nanomedicine.
abstract: Nanomedicine can take advantage of the recent developments in nanobiotechnology research areas for the creation of platforms with superior drug carrier capabilities, selective responsiveness to the environment, unique contrast enhancement profiles and improved accumulation at the disease site. Colloidal inorganic nanoparticles (NPs) have been attracting considerable interest in biomedicine, from drug and gene delivery to imaging, sensing and diagnostics. It is essential to modify the NPs surface to have enhanced biocompatibility and reach multifunctional systems for the in vitro and in vivo applications, especially in delivering drugs locally and recognizing overexpressed biomolecules. This paper describes the rational design for dendrimer-nanoparticle conjugates elaboration and reviews their state-of-the-art uses as efficient nanomedicine tools.
authors: Institut de Physique et de Chimie des Matériaux de Strasbourg IPCMS, UMR CNRS-UdS 7504, 23 rue du Loess, BP 43, 67034 STRASBOURG CEDEX 2, France.
authors: Audrey
authors: A
authors: Parat
authors: Catalina
authors: C
authors: Bordeianu
authors: Hanna
authors: H
authors: Dib
authors: Antonio
authors: A
authors: Garofalo
authors: Aurélie
authors: A
authors: Walter
authors: Sylvie
authors: S
authors: Bégin-Colin
authors: Delphine
authors: D
authors: Felder-Flesch
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media; D050091:Dendrimers / Q000737:chemistry*; D003952:Diagnostic Imaging / Q000379:methods; D004337:Drug Carriers; D005290:Ferric Compounds / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D057054:Molecular Imaging; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D045663:Quantum Dots
chemical_list: D003287:Contrast Media; D050091:Dendrimers; D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide; D006046:Gold
keywords: MRI; dendrimers; dendrons; gold nanoparticles; optical imaging; quantum dots; superparamagnetic iron oxide; tumor targeting