title: [Analysis of the changes of blood glucose after radiotherapy in pancreatic cancer patients associated with diabetes mellitus and their related factors].
abstract: OBJECTIVE
  To investigate the changes of blood glucose in pancreatic cancer patients associated with diabetes mellitus (DM) after radiotherapy and analyze the related factors.
  
  
  METHODS
  Clinical data of 69 cases of stage I to III pancreatic carcinoma associated with DM were retrospectively analyzed. All patients were divided into four groups according to the history of DM, and the clinical characteristics and blood glucose changes after stereotactic radiotherapy were analyzed. The correlation between blood glucose and serum tumor markers was analyzed.
  
  
  RESULTS
  No significant differences were found in clinical characteristics of the four groups. The history of DM <12 months accounted for 39.1% of the pancreatic cancer patients, much more higher than that of patients with a longer disease course. After radiotherapy, the blood glucose changes were not significantly different between the two groups with DM history <12 months and 12-24 months (P = 0.519), but there were significant differences between the patients with DM history <12 months and those with DM history 25-36 months and >36 months (P < 0.05 for both). After radiotherapy, CA199/CEA was reduced and blood glucose was also improved in the patients with DM history <12 months and 12-24 months, and the reduction of CA199/CEA showed a significant positive correlation with the improvement of blood glucose (r = 0.834 and r = 0.660, P < 0.01 for both), however, no significant correlation was found between the two parameters in patients with DM history 25-36 months and >36 months (r = 0.319 and r = 0.439, P > 0.05 for both).
  
  
  CONCLUSIONS
  Hyperglycemia in diabetic patients with a disease course <24 months might be a clinical manifestation secondarily developed in pancreatic cancer patients. Therefore, patients with new onset diabetes should be closely followed-up for early detection of pancreatic cancer.
authors: Shanghai Center of Radiation Oncology, Chinese People's Armed Police Forces, Shanghai 201103, China.
authors: Yong
authors: Y
authors: Li
authors: Shanghai Center of Radiation Oncology, Chinese People's Armed Police Forces, Shanghai 201103, China. Email: panmianshun@126.com.
authors: Mianshun
authors: M
authors: Pan
authors: Shanghai Center of Radiation Oncology, Chinese People's Armed Police Forces, Shanghai 201103, China.
authors: Shujun
authors: S
authors: Qiu
authors: Shanghai Center of Radiation Oncology, Chinese People's Armed Police Forces, Shanghai 201103, China.
authors: Peng
authors: P
authors: Wang
authors: Shanghai Center of Radiation Oncology, Chinese People's Armed Police Forces, Shanghai 201103, China.
authors: Xianjun
authors: X
authors: Shao
authors: Shanghai Center of Radiation Oncology, Chinese People's Armed Police Forces, Shanghai 201103, China.
authors: Li
authors: L
authors: Zhang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D001786:Blood Glucose