title: Aspirin and Acetaminophen Use and the Risk of Cervical Cancer.
abstract: OBJECTIVE
  In this study, we investigated whether regular use of aspirin or acetaminophen was associated with risk of cervical cancer in women treated at an American cancer hospital.
  
  
  METHODS
  This case-control study included 328 patients with cervical cancer and 1,312 controls matched on age and decade enrolled. Controls were women suspected of having but not ultimately diagnosed with a neoplasm. Analgesic use was defined as regular (at least once per week for ≥6 months), frequent (≥7 tablets/week), very long term (≥11 years), or frequent, long term (≥7 tablets per week for ≥5 years).
  
  
  RESULTS
  Compared to nonusers, frequent aspirin use was associated with decreased odds of cervical cancer (odds ratio, 0.53; 95% confidence interval, 0.29-0.97). A slightly larger association was observed with frequent, long-term use of aspirin (odds ratio, 0.46; 95% confidence interval, 0.22-0.95). Acetaminophen use was not associated with the risk of cervical cancer.
  
  
  CONCLUSIONS
  Our findings suggest that frequent and frequent, long-term use of aspirin is associated with decreased odds of cervical cancer. To our knowledge, this is the first US-based study examining these associations. Given the widespread use of nonsteroidal anti-inflammatory drugs and acetaminophen worldwide, further investigations of the possible role of analgesics in cervical cancer, using a larger sample size with better-defined dosing regimens, are warranted.
authors: 1Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY; 2Department of Obstetrics and Gynecology, University at Buffalo SUNY, Buffalo, NY; 3Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY; and 4Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL.
authors: Grace
authors: G
authors: Friel
authors: Cici S
authors: CS
authors: Liu
authors: Nonna V
authors: NV
authors: Kolomeyevskaya
authors: Shalaka S
authors: SS
authors: Hampras
authors: Bridget
authors: B
authors: Kruszka
authors: Kristina
authors: K
authors: Schmitt
authors: Rikki A
authors: RA
authors: Cannioto
authors: Shashikant B
authors: SB
authors: Lele
authors: Kunle O
authors: KO
authors: Odunsi
authors: Kirsten B
authors: KB
authors: Moysich
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use*; D002173:Cancer Care Facilities; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009518:New York; D012307:Risk Factors; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000517:prevention & control*
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; D001241:Aspirin