title: A plasmonic aptasensor for ultrasensitive detection of thrombin via arrested rolling circle amplification.
abstract: A sensitive signal generation mechanism for gold nanoparticle growth by reducing gold ions with hydrogen peroxide is applied in a plasmonic aptasensor, achieving naked-eye detection of thrombin at the single-molecule level based on the specific interaction of aptamer-thrombin via an arrested rolling circle amplification to yield horseradish peroxidase (HRP)-mimicking DNAzymes as biocatalysts.
authors: College of Chemical Science and Engineering, Laboratory of Fiber Materials and Modern Textiles, The Growing Base for State Key Laboratory, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles, Qingdao University, Qingdao 266071, P. R. China. bisai11@126.com wangzonghua@qdu.edu.cn.
authors: Sai
authors: S
authors: Wang
authors: Sai
authors: S
authors: Bi
authors: Zonghua
authors: Z
authors: Wang
authors: Jianfei
authors: J
authors: Xia
authors: Feifei
authors: F
authors: Zhang
authors: Min
authors: M
authors: Yang
authors: Rijun
authors: R
authors: Gui
authors: Yanhui
authors: Y
authors: Li
authors: Yanzhi
authors: Y
authors: Xia
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000378:metabolism; D055162:Biocatalysis; D004261:DNA Replication; D021881:DNA, Catalytic / Q000737:chemistry / Q000378:metabolism*; D004270:DNA, Circular; D006046:Gold / Q000737:chemistry* / Q000378:metabolism; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry*; D013917:Thrombin / Q000032:analysis* / Q000378:metabolism
chemical_list: D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D004270:DNA, Circular; C081676:thrombin aptamer; D006046:Gold; D006861:Hydrogen Peroxide; D006735:Horseradish Peroxidase; D013917:Thrombin