title: Salidroside prevents cognitive impairment induced by chronic cerebral hypoperfusion in rats.
abstract: OBJECTIVE
  To investigate the effects of salidroside on cognitive dysfunction induced by chronic cerebral hypoperfusion in rats.
  
  
  METHODS
  Male Sprague-Dawley rats (n = 36) were divided into three groups (n = 12 per group): sham operation; bilateral permanent occlusion of the common carotid arteries (2-VO); 2-VO + salidroside. Rats received 20 mg/kg per day salidroside or vehicle intraperitoneal injection beginning the day before surgery and continuing until 34 days postoperatively. Cognitive function was evaluated by Morris water maze test and hippocampal long-term potentiation (LTP) measurement. Hippocampal neuronal apoptosis was evaluated via immunofluorescence.
  
  
  RESULTS
  Chronic cerebral hypoperfusion caused marked cognitive deficit and LTP inhibition. These effects were largely ameliorated by salidroside administration. Salidroside prevented caspase-3 activation, increased the ratio of Bax/Bcl-2, and reversed hippocampal neuronal loss induced by chronic cerebral hypoperfusion.
  
  
  CONCLUSIONS
  Salidroside prevents cognitive deficits caused by chronic cerebral hypoperfusion in rats, and alleviates apoptosis in the hippocampal CA1 area.
authors: Department of Neurosurgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China Department of Neurosurgery, Urumqi General Hospital of Lanzhou Military Command, Urumqi, China.
authors: Zhi-Qiang
authors: ZQ
authors: Yan
authors: Department of Encephalopathy, Traditional Chinese Medicine Hospital of Shan Xi Province, Xi'an, China.
authors: Jun
authors: J
authors: Chen
authors: Department of Neurosurgery, Urumqi General Hospital of Lanzhou Military Command, Urumqi, China.
authors: Guo-Xiang
authors: GX
authors: Xing
authors: Department of Neurosurgery, Urumqi General Hospital of Lanzhou Military Command, Urumqi, China.
authors: Jian-Guo
authors: JG
authors: Huang
authors: Department of Nutrition and Food Hygiene, The Fourth Military Medical University, Xi'an, China.
authors: Xiang-Hong
authors: XH
authors: Hou
authors: Department of Anatomy, Histology and Embryology, K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, China zhangyongdoctor@163.com.
authors: Yong
authors: Y
authors: Zhang
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D058256:Brain Waves / Q000502:physiology; D002339:Carotid Arteries / Q000601:surgery; D016893:Carotid Stenosis / Q000601:surgery*; D002560:Cerebrovascular Circulation; D003072:Cognition Disorders / Q000188:drug therapy / Q000517:prevention & control*; D015140:Dementia, Vascular / Q000188:drug therapy* / Q000517:prevention & control; D004195:Disease Models, Animal; D005960:Glucosides / Q000627:therapeutic use*; D006624:Hippocampus / Q000502:physiology / Q000503:physiopathology; D008297:Male; D018782:Maze Learning; D010636:Phenols / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D029771:Rhodiola / Q000378:metabolism
chemical_list: D005960:Glucosides; D010636:Phenols; D010936:Plant Extracts; C009172:rhodioloside
keywords: Salidroside; apoptosis; chronic cerebral hypoperfusion; cognition