title: Endotipsitis: A case report with a literature review on an emerging prosthetic related infection.
abstract: OBJECTIVE
  To investigate the etiology and management of a poorly understood complication of transjugular intrahepatic portosystemic shunt; "endotipsitis".
  
  
  METHODS
  A MEDLINE database search was carried out, reviewing all papers with specific words in the title or abstract, and excluding appropriately. Of 283 papers that were reviewed, 22 papers reporting 53 cases in total were included in the analyses.
  
  
  RESULTS
  No predominant etiology for endotipsitis was identified, but gram-positive organisms were more common among early-onset infections (P < 0.01). A higher mortality rate was associated with Staphylococcus aureus and Candida spp infections (P < 0.01). There was no trend in choice of antibiotic based on the microorganisms isolated and treatment varied from the guidelines of other vegetative prosthetic infections. In endotipsitis "high risk" organisms have been identified, emphasizing the importance of ensuring optimal antimicrobial therapy and adjunctive management strategies.
  
  
  CONCLUSIONS
  Higher mortality rate was associated with Staphylococcus aureus and Candida spp infections. A prospective multicenter trial is needed before specific treatment can be recommended.
authors: Annalan MD Navaratnam, Department of Infectious Disease Epidemiology, Imperial College London, W2 1PG London, United Kingdom.
authors: Annalan Md
authors: AM
authors: Navaratnam
authors: Annalan MD Navaratnam, Department of Infectious Disease Epidemiology, Imperial College London, W2 1PG London, United Kingdom.
authors: Matthew
authors: M
authors: Grant
authors: Annalan MD Navaratnam, Department of Infectious Disease Epidemiology, Imperial College London, W2 1PG London, United Kingdom.
authors: David B
authors: DB
authors: Banach
keywords: Antimicrobial therapy; Persistent bacteremia; Tipsitis; Transjugular intrahepatic portosystemic shunt infection; Transjugular intrahepatic portosystemic shunts