title: Increased Mean Platelet Volume in Familial Hypercholesterolemia.
abstract: Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism and increases the risk of premature cardiovascular diseases. In patients with FH, platelet function may be activated; however, the extent of this activation and its etiology are unclear. We aimed to evaluate the mean platelet volume (MPV), a marker of platelet activation, in patients with FH. The study group consisted of 164 patients with FH and 160 control patients. Controls were matched for age, gender, hypertension, and smoking. The MPV was significantly higher in patients with FH than in controls (9.2 ± 0.4 vs 7.9 ± 0.6 fL, respectively; P < .001). Platelet count was significantly lower among patients with FH when compared to control patients (259 ± 51 vs 272 ± 56 × 10(3)/L, respectively; P = .03). In linear regression analysis, MPV was independently associated only with total cholesterol (β = .6, 95% confidence interval: 0.004-0.008, P < .001). We have shown that MPV was increased in patients with FH and that it was independently associated with total cholesterol level.
authors: Department of Cardiology, Ahi Evran University, Kirsehir, Turkey atillaicli@hotmail.com.
authors: Atilla
authors: A
authors: Icli
authors: Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
authors: Fatih
authors: F
authors: Aksoy
authors: Department of Cardiology, Ahi Evran University, Kirsehir, Turkey.
authors: Gökay
authors: G
authors: Nar
authors: Department of Neurosurgery, Ahi Evran University Education and Research Hospital, Kirsehir, Turkey.
authors: Haci
authors: H
authors: Kaymaz
authors: Department of Cardiovascular Surgery, Ahi Evran University, Kirsehir, Turkey.
authors: Mehmet Fatih
authors: MF
authors: Alpay
authors: Department of Biochemistry, Ahi Evran University, Kirsehir, Turkey.
authors: Rukiye
authors: R
authors: Nar
authors: Department of Nephrology, Ahi Evran University, Kirsehir, Turkey.
authors: Aydın
authors: A
authors: Guclu
authors: Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
authors: Akif
authors: A
authors: Arslan
authors: Department of Cardiology, Katip Celebi University, Izmir, Turkey.
authors: Abdullah
authors: A
authors: Dogan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000175:diagnosis / Q000235:genetics; D016014:Linear Models; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D015539:Platelet Activation; D010976:Platelet Count; D011237:Predictive Value of Tests; D014421:Turkey
chemical_list: D015415:Biomarkers; D002784:Cholesterol
keywords: familial hypercholesterolemia; mean platelet volume; platelet activation; platelet count