title: The Impact of Genetic Variants for Different Physiological Characterization of Type 2 Diabetes Loci on Gestational Insulin Signaling in Nondiabetic Pregnant Chinese Women.
abstract: We investigate the impact of genetic variants on transiently upregulated gestational insulin signaling. We recruited 1152 unrelated nondiabetic pregnant Han Chinese women (age 28.5 ± 4.1 years; body mass index [BMI] 21.4 ± 2.6 kg/m(2)) and gave them oral glucose tolerance tests. Matsuda index of insulin sensitivity, homeostatic model assessment of insulin resistance, indices of insulin disposition, early-phase insulin release, fasting state, and 0 to 120 minute's proinsulin to insulin conversion were used to dissect insulin physiological characterization. Several variants related to β-cell function were genotyped. The genetic impacts were analyzed using logistic regression under an additive model. By adjusting for maternal age, BMI, and the related interactions, the genetic variants in ABCC8, CDKAL1, CDKN2A, HNF1B, KCNJ11, and MTNR1B were detected to impact gestational insulin signaling through heterogeneous mechanisms; however, compared with that in nonpregnant metabolism, the genetic effects seem to be eminently and heavily influenced by maternal age and BMI, indicating possible particular mechanisms underlying gestational metabolism and diabetic pathogenesis.
authors: Diabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China shunyaol@yahoo.com sdeng10@yahoo.com.
authors: Shunyao
authors: S
authors: Liao
authors: Department of Medical Genetics, Division of Morbid Genomics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
authors: Yunqiang
authors: Y
authors: Liu
authors: Columbia Center for Translational Immunology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors: Xiaojuan
authors: X
authors: Chen
authors: College of Life Science, Hunan Normal University, Changsha, Hunan, China.
authors: Yuande
authors: Y
authors: Tan
authors: Department of Obstetrics and Gynecology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
authors: Jie
authors: J
authors: Mei
authors: Department of Nuclear Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
authors: Wenzhong
authors: W
authors: Song
authors: Diabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
authors: Lu
authors: L
authors: Gan
authors: Diabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
authors: Hailian
authors: H
authors: Wang
authors: Diabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
authors: Shi
authors: S
authors: Yin
authors: Diabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
authors: Xianjue
authors: X
authors: Dong
authors: Department of Nuclear Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
authors: Shu
authors: S
authors: Chi
authors: Diabetes Center & Institute of Transplantation, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China Human Islet Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA shunyaol@yahoo.com sdeng10@yahoo.com.
authors: Shaoping
authors: S
authors: Deng
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001786:Blood Glucose / Q000235:genetics / Q000378:metabolism; D015992:Body Mass Index; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology / Q000235:genetics*; D016640:Diabetes, Gestational / Q000208:ethnology / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D056426:Genetic Loci; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance / Q000208:ethnology / Q000235:genetics; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D016015:Logistic Models; D008423:Maternal Age; D010641:Phenotype; D011247:Pregnancy; D015398:Signal Transduction; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D005819:Genetic Markers; D007328:Insulin
keywords: genetic variants; gestational diabetes; gestational insulin signaling