title: Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins.
abstract: Like all viruses, influenza viruses (IAVs) use host translation machinery to decode viral mRNAs. IAVs ensure efficient translation of viral mRNAs through host shutoff, a process whereby viral proteins limit the accumulation of host proteins through subversion of their biogenesis. Despite its small genome, the virus deploys multiple host shutoff mechanisms at different stages of infection, thereby ensuring successful replication while limiting the communication of host antiviral responses. In this Gem, we review recent data on IAV host shutoff proteins, frame the outstanding questions in the field, and propose a temporally coordinated model of IAV host shutoff.
authors: Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
authors: Denys A
authors: DA
authors: Khaperskyy
authors: Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada craig.mccormick@dal.ca.
authors: Craig
authors: C
authors: McCormick
mesh_terms: D054884:Host-Pathogen Interactions; D009980:Influenza A virus / Q000254:growth & development / Q000502:physiology*; D012097:Repressor Proteins / Q000378:metabolism*; D013995:Time; D017361:Viral Nonstructural Proteins / Q000378:metabolism*; D014779:Virus Replication
chemical_list: C085820:INS1 protein, influenza virus; C573926:PA-X protein, influenza A virus; D012097:Repressor Proteins; D017361:Viral Nonstructural Proteins