title: Solitary pituitary metastasis from HER2-positive breast cancer.
abstract: The introduction of anti-HER2 therapy with trastuzumab has seen an increase in frequency of central nervous system metastasis as the site of first recurrence. Here, we present a rare case of a 63-year-old woman who presented with an isolated breast carcinoma pituitary metastasis 5 years following treatment for a high-risk breast cancer. This report underscores the changing nature of HER2-positive disease in the post-trastuzumab era.
authors: Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
authors: Jeremy
authors: J
authors: Kam
authors: Breast Service, Royal Melbourne Hospital and Royal Women's Hospital, Melbourne, Victoria, Australia.
authors: Jeffrey
authors: J
authors: Kam
authors: Breast Service, Royal Melbourne Hospital and Royal Women's Hospital, Melbourne, Victoria, Australia.
authors: G Bruce
authors: GB
authors: Mann
authors: Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors: Claire
authors: C
authors: Phillips
authors: Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.|Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
authors: John M
authors: JM
authors: Wentworth
authors: Department of Neurosurgery, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
authors: James
authors: J
authors: King
authors: Department of Medical Oncology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.|Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.|Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.
authors: Geoffrey J
authors: GJ
authors: Lindeman
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications*; D016543:Central Nervous System Neoplasms / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000209:etiology* / Q000473:pathology; D018719:Erb-b2 Receptor Tyrosine Kinases
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018719:Erb-b2 Receptor Tyrosine Kinases