title: Characterization of the impurities and isomers in cefetamet pivoxil hydrochloride by liquid chromatography/time-of-flight mass spectrometry and ion trap mass spectrometry.
abstract: Ten impurities and isomers in cefetamet pivoxil hydrochloride drug substance made in China were separated and identified by HPLC-MS(n) (TOF and TRAP). Their fragmentation patterns and structural assignment were studied based on the HPLC-MS(n) data. Among the ten impurities and isomers, impurity VII was isolated by preparative HPLC, and its structure was confirmed by (1)H NMR data.
authors: Zhejiang University of Technology, Hangzhou 310004, China; Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China.
authors: Dandan
authors: D
authors: Wang
authors: School of Medicine, Zhejiang University, Hangzhou 310004, China.
authors: Fan
authors: F
authors: Wang
authors: Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China. Electronic address: wangjianhw2000@aliyun.com.
authors: Jian
authors: J
authors: Wang
mesh_terms: D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D002681:China; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004340:Drug Contamination; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods
chemical_list: D015296:Ceftizoxime; C047445:cefetamet pivoxyl
keywords: Cefetamet pivoxil hydrochloride; Characterization; Impurity and isomer; Liquid chromatography/ion trap mass spectrometry; Liquid chromatography/quadrupole time-of-flight mass spectrometry