title: PINK1 activation-turning on a promiscuous kinase.
abstract: PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a serine/threonine kinase targeted to mitochondria and implicated in early-onset recessive Parkinson's disease (PD). Through the phosphorylation of its downstream targets, PINK1 regulates multiple mitochondrial processes, including ATP production, stress-response and mitochondrial dynamics and quality control. The orchestration of such a wide array of functions by an individual kinase requires a fine-tuned and versatile regulation of its activity. PINK1 proteolytic processing, trafficking and localization, as well as different post-translational modifications, affect its activity and function. Unravelling the regulatory mechanisms of PINK1 is essential for a full comprehension of its kinase function in health and disease.
authors: *Center for Human Genetics, LIND and KU Leuven, O&N1 Herestraat 49 box 602, 3000 Leuven, Belgium.
authors: Liesbeth
authors: L
authors: Aerts
authors: *Center for Human Genetics, LIND and KU Leuven, O&N1 Herestraat 49 box 602, 3000 Leuven, Belgium.
authors: Bart
authors: B
authors: De Strooper
authors: *Center for Human Genetics, LIND and KU Leuven, O&N1 Herestraat 49 box 602, 3000 Leuven, Belgium.
authors: Vanessa A
authors: VA
authors: Morais
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D006801:Humans; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D021381:Protein Transport / Q000235:genetics*; D000099202:PTEN-Induced Putative Kinase
chemical_list: D000255:Adenosine Triphosphate; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D000099202:PTEN-Induced Putative Kinase