title: Cardiac rehabilitation versus standard care after aortic aneurysm repair (Aneurysm CaRe): study protocol for a randomised controlled trial.
abstract: BACKGROUND
  Abdominal and thoracic aortic aneurysms (A/TAA) are an important cause of mortality amongst the older population. Although A/TAA repair can be performed with low peri-operative risk, overall life expectancy remains poor in the years that follow surgery. The majority of deaths are caused by heart attack or stroke, which can both be prevented by cardiac rehabilitation (CR) in patients with clinically-manifest coronary artery disease. A Cochrane review has urged researchers to widen the use of CR to other populations with severe cardiovascular risk, and patients surviving A/TAA repair appear ideal candidates. However, it is unknown whether CR is feasible or acceptable to A/TAA patients, who are a decade older than those currently enrolling in CR. Aneurysm-CaRe is a feasibility randomised controlled trial (RCT) that will address these issues.
  
  
  METHODS
  Aneurysm-CaRe is a pilot RCT of CR versus standard care after A/TAA repair, with the primary objectives of estimating enrolment to a trial of CR after A/TAA repair and estimating compliance with CR amongst patients with A/TAA. Aneurysm-CaRe will randomise 84 patients at two sites. Patients discharged from hospital after elective A/TAA repair will be randomised to standard care or enrolment in their local CR programme with a protocolised approach to medical cardiovascular risk reduction. The primary outcome measures are enrolment in the RCT and compliance with CR. Secondary outcomes will include phenotypic markers of cardiovascular risk and smoking cessation, alongside disease-specific and generic quality-of-life measures.
  
  
  BACKGROUND
  ISRCTN 65746249 5 June 2014.
authors: Department of Outcomes Research, St George's Vascular Institute, St George's Healthcare NHS Trust, Room 4.007, Blackshaw Road, London, SW17 0QT, UK. bahia_sandeep@yahoo.co.uk.|Department of Cardiovascular Sciences, St George's University of London, London, SW17 0RE, UK. bahia_sandeep@yahoo.co.uk.
authors: Sandeep S
authors: SS
authors: Bahia
authors: Department of Outcomes Research, St George's Vascular Institute, St George's Healthcare NHS Trust, Room 4.007, Blackshaw Road, London, SW17 0QT, UK. pholt@sgul.ac.uk.|Department of Cardiovascular Sciences, St George's University of London, London, SW17 0RE, UK. pholt@sgul.ac.uk.
authors: Peter J
authors: PJ
authors: Holt
authors: Department of Cardiovascular Sciences, St George's University of London, London, SW17 0RE, UK. koshray@gmail.com.
authors: Kausik K
authors: KK
authors: Ray
authors: Population Health Research Institute, St George's University of London, London, SW17 0RE, UK. mussher@sgul.ac.uk.
authors: Michael
authors: M
authors: Ussher
authors: Population Health Research Institute, St George's University of London, London, SW17 0RE, UK. sggp300@sgul.ac.uk.
authors: Jan D
authors: JD
authors: Poloniecki
authors: Department of Cardiovascular Sciences, St George's University of London, London, SW17 0RE, UK. rajan.sharma@stgeorges.nhs.uk.
authors: Rajan
authors: R
authors: Sharma
authors: Department of Cardiovascular Sciences and NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK. mjb42@leicester.ac.uk.
authors: Matthew J
authors: MJ
authors: Bown
authors: Department of Outcomes Research, St George's Vascular Institute, St George's Healthcare NHS Trust, Room 4.007, Blackshaw Road, London, SW17 0QT, UK. rhinchli@sgul.ac.uk.|Department of Cardiovascular Sciences, St George's University of London, London, SW17 0RE, UK. rhinchli@sgul.ac.uk.
authors: Robert J
authors: RJ
authors: Hinchliffe
authors: Department of Outcomes Research, St George's Vascular Institute, St George's Healthcare NHS Trust, Room 4.007, Blackshaw Road, London, SW17 0QT, UK. matt.thompson@stgeorges.nhs.uk.|Department of Cardiovascular Sciences, St George's University of London, London, SW17 0RE, UK. matt.thompson@stgeorges.nhs.uk.
authors: Matthew M
authors: MM
authors: Thompson
authors: Department of Outcomes Research, St George's Vascular Institute, St George's Healthcare NHS Trust, Room 4.007, Blackshaw Road, London, SW17 0QT, UK. alankarthi@gmail.com.|Department of Cardiovascular Sciences, St George's University of London, London, SW17 0RE, UK. alankarthi@gmail.com.
authors: Alan
authors: A
authors: Karthikesalingam
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D002985:Clinical Protocols; D003153:Community Health Services; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008131:London; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000534:rehabilitation*; D010349:Patient Compliance; D010351:Patient Discharge; D010865:Pilot Projects; D011788:Quality of Life; D012107:Research Design; D018570:Risk Assessment; D012307:Risk Factors; D040242:Risk Reduction Behavior; D016540:Smoking Cessation; D020521:Stroke / Q000175:diagnosis / Q000401:mortality; D000071939:Stroke Rehabilitation; D013997:Time Factors; D016896:Treatment Outcome