title: Synchronous quadruple primary neoplasms: glioblastoma, neuroendocrine tumor, schwannoma and sessile serrated adenoma in a patient with history of prostate cancer.
abstract: Quadruple synchronous primary neoplasms are exceedingly rare with only one case reported in the English literature. We herein report a case of synchronous quadruple primary neoplasms in a 70-year-old Arabic male with a history of prostate cancer who presented to our hospital for work-up of a brain mass found at an outside hospital. Subsequent (18)Fluorodeoxyglucose (FDG) positron emission tomography demonstrated a 5.9-cm temporoparietal mass and three additional lesions, each with increased maximum standardized uptake value (SUV(max)). Histologic examination, immunohistochemistry and cytogenetic analyses of the lesional tissue revealed four primary neoplastic lesions: primary glioblastoma, inguinal schwannoma, well-differentiated neuroendocrine tumor of the terminal ileum and an appendiceal sessile serrated adenoma/polyp. This case is unique among previous reports as our patient presented with four primary neoplasms synchronously. To the best of our knowledge, this combination of synchronous multiple primary neoplasms has not been reported in the English literature.
authors: Department of Pathology, Saint Louis University, Saint Louis, MO, U.S.A.
authors: Shane
authors: S
authors: Grace
authors: Department of Radiology, Saint Louis University, Saint Louis, MO, U.S.A.
authors: Razi
authors: R
authors: Muzaffar
authors: Department of Surgery, Saint Louis University, Saint Louis, MO, U.S.A.
authors: Jula
authors: J
authors: Veerapong
authors: Department of Internal Medicine, Saint Louis University, Saint Louis, MO, U.S.A.
authors: Samer
authors: S
authors: Alkaade
authors: Department of Internal Medicine, Saint Louis University, Saint Louis, MO, U.S.A.
authors: Nishant
authors: N
authors: Poddar
authors: Department of Pathology, Saint Louis University, Saint Louis, MO, U.S.A.
authors: Nancy
authors: N
authors: Phillips
authors: Department of Pathology, Saint Louis University, Saint Louis, MO, U.S.A.
authors: Miguel
authors: M
authors: Guzman
authors: Department of Pediatrics, Saint Louis University, Saint Louis, MO, U.S.A.
authors: Jacqueline
authors: J
authors: Batanian
authors: Department of Pathology, Saint Louis University, Saint Louis, MO, U.S.A.
authors: Carole
authors: C
authors: Vogler
authors: Department of Pathology, Saint Louis University, Saint Louis, MO, U.S.A. jinpinglai@slu.edu.
authors: Jin-Ping
authors: JP
authors: Lai
mesh_terms: D000368:Aged; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology*; D009442:Neurilemmoma / Q000000981:diagnostic imaging / Q000473:pathology*; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography
keywords: Synchronous; glioblastoma; glioblastoma multiforme; multiple primary malignant neoplasms; neuroendocrine tumor; schwannoma; sessile serrated adenoma/polyp