title: Adherence with immunosuppression in heart transplant recipients.
abstract: OBJECTIVE
  Nonadherence is a major problem in heart transplantation (htx) and a challenge for clinical practice and research. In heart transplant recipients, nonadherence could cause chronic rejection of the transplanted heart followed by difficult clinical course and/or death of the patient.
  
  
  RESULTS
  Main topics are the relationship between psychological aspects and adherence, risk factors and prediction of nonadherence, strategies for improving adherence like single-dose immunosuppressant therapy and follow-up studies.
  
  
  CONCLUSIONS
  There is a lack of behavioral intervention studies. So-called targeted interventions should be defined for clinical practice and research with randomized controlled studies.
authors: aDepartment of Psychosomatics and Psychotherapy, University Hospital of Cologne, Cologne, Germany bDepartment of Psychosomatics, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13535 Berlin, Germany.
authors: Frank
authors: F
authors: Vitinius
authors: Maria
authors: M
authors: Ziemke
authors: Wolfgang
authors: W
authors: Albert
mesh_terms: D018479:Early Intervention, Educational; D006084:Graft Rejection / Q000517:prevention & control; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D012307:Risk Factors; D066027:Transplant Recipients
chemical_list: D007166:Immunosuppressive Agents