title: Palladium(0)/PAr3 -Catalyzed Intermolecular Amination of C(sp(3) )H Bonds: Synthesis of β-Amino Acids.
abstract: An intermolecular C(sp(3))-H amination using a Pd(0) /PAr3 catalyst was developed. The reaction begins with oxidative addition of R2 N-OBz to a Pd(0) /PAr3 catalyst and subsequent cleavage of a C(sp(3))-H bond by the generated Pd-NR2 intermediate. The catalytic cycle proceeds without the need for external oxidants in a similar manner to the extensively studied palladium(0)-catalyzed C-H arylation reactions. The electron-deficient triarylphosphine ligand is crucial for this C(sp(3))-H amination reaction to occur.
authors: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors: Jian
authors: J
authors: He
authors: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).
authors: Toshihiko
authors: T
authors: Shigenari
authors: Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA). yu200@scripps.edu.
authors: Jin-Quan
authors: JQ
authors: Yu
mesh_terms: D000586:Amination; D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry
chemical_list: D000596:Amino Acids; D010720:Phosphines; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; C044646:phosphine
keywords: CH activation; amination; amino acids; palladium; synthetic methods