title: A facile synthesis and antimicrobial activity evaluation of sydnonyl-substituted thiazolidine derivatives.
abstract: Some new sydnonyl-substituted thiazolidine derivatives were synthesized in high yields by the modified Knoevenagel condensation of 3-aryl-4-formylsydnones with thiazolidine-2,4-dione and 2-thioxo-thiazolidine-4-one, respectively. All the synthesized thiazolidine derivatives were screened by paper-disc method to identify their antimicrobial activities against three bacteria viz. Staphylococcus aureus, Proteus vulgaris and Escherichia coli, and two fungal cultures viz. Aspergillus niger and Penicillium citrinum. The reference drugs were Norfloxacin and Griseofulvin, respectively. The screening data indicated that the tested sydnonyl-substituted thiazolidine derivatives exhibited no obvious antibacterial activity compared with the standard drug Norfloxacin. However, thiazolidine derivatives displayed significant antifungal activities against Penicillium citrinum and Aspergillus niger. Notably, all of the tested compounds showed growth inhibitory activity 1.5-4.4 times higher than that of the standard drug Griseofulvin against the two fungi.
authors: Department of Chemical and Materials Engineering, Southern Taiwan University of Science and Technology, Tainan City 71005, Taiwan. meihsius@mail.stust.edu.tw.
authors: Mei-Hsiu
authors: MH
authors: Shih
authors: Department of Chemical and Materials Engineering, Southern Taiwan University of Science and Technology, Tainan City 71005, Taiwan. ma140107@stust.edu.tw.
authors: Yu-Yuan
authors: YY
authors: Xu
authors: Department of Chemical and Materials Engineering, Southern Taiwan University of Science and Technology, Tainan City 71005, Taiwan. ma140201@stust.edu.tw.
authors: Yu-Sheng
authors: YS
authors: Yang
authors: Department of Chemical and Materials Engineering, Southern Taiwan University of Science and Technology, Tainan City 71005, Taiwan. lynnlin0221@yahoo.com.tw.
authors: Guan-Ling
authors: GL
authors: Lin
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013558:Sydnones / Q000737:chemistry; D053778:Thiazolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D013558:Sydnones; D053778:Thiazolidines