title: A multi-center study on the prophylactic application of antibiotics in aseptic operations.
abstract: To understand the application of antibacterial agents in aseptic operations and to provide evidence for their rational use and management, the antibiotic use statuses of six types of aseptic operations (306 cases from 4 tertiary hospitals) were retrospectively analyzed. Of 312 patients, 306 (65.08%) were treated with antibacterial agents in the perioperative period. Four categories of antibiotics including cephalosporins, penicillins, nitroimidazoles, and fluoroquinolones were administered (descending sequence). Administration time: preoperative >2 h, 15 cases; preoperative 0.5-2 h, 20 cases; postoperative: 265 cases. Drug withdrawal time: postoperative 1-3 days: 33 cases; 3-7 days: 255 cases; 7-15 days: 12 cases. The prophylactic use of antibacterial agents in aseptic operations suffers from non-strict mastered medication indication, improper drug selection, aimless drug combinations, inappropriate administration timing, and over long medication duration.
authors: Pharmacology Section of Basic Medicine School, Inner Mongolia Medical University, Hohhot, China.
authors: Y
authors: Y
authors: Ma
authors: Department of Pharmacology, Affiliated hospital of Inner Mongolia Medical University, Hohhot, China.
authors: L
authors: L
authors: Bao
authors: Pharmacology Section of Basic Medicine School, Inner Mongolia Medical University, Hohhot, China 349881704@qq.com.
authors: H
authors: H
authors: Wang
authors: Pharmacology Section of Basic Medicine School, Inner Mongolia Medical University, Hohhot, China.
authors: S
authors: S
authors: Shi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D002511:Cephalosporins / Q000627:therapeutic use; D002648:Child; D004334:Drug Administration Schedule; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use; D017063:Outcome Assessment, Health Care; D010406:Penicillins / Q000627:therapeutic use; D011184:Postoperative Period; D057234:Preoperative Period; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D024841:Fluoroquinolones; D009593:Nitroimidazoles; D010406:Penicillins