title: Design and synthesis of 2'-deoxy-2'-[(1,2,3)triazol-1-yl]uridines using click chemistry approach.
abstract: A series of novel nucleosides bearing a 1,2,3-triazole moiety at the 2'-position of the sugar moiety has been synthesized starting from 2'-azidouridine and using the copper (I)-catalyzed Huisgen-Sharpless-Meldal 1,3-dipolar cycloaddition reaction. The reactions proceeded in overall yield of 52-82% and gave almost exclusively the 1,4-disubstituted 1,2,3-triazoles. The 2'-azidouridine was synthesized from uridine in two steps, and reacted with a variety of differently substituted alkynes to give the desired 2'-triazole-substituted uridine derivatives.
authors: a Department of Chemistry, University College, Kurukshetra University , Kurukshetra , Haryana , India.
authors: Surender
authors: S
authors: Kumar
mesh_terms: D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry; D061565:Cycloaddition Reaction; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry*; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D014230:Triazoles; D003300:Copper; D014529:Uridine
keywords: 1,2,3-triazole; 2′-azidouridine; Nucleosides; click chemistry