title: Acute exercise does not decrease liver fat in men with overweight or NAFLD.
abstract: Elevated hepatic lipid content (IntraHepatic Lipid, IHL) increases the risk of metabolic complications. Although prolonged exercise training lowers IHL, it is unknown if acute exercise has the same effect. Furthermore, hepatic ATP content may be related to insulin resistance and IHL. We aimed to investigate if acute exercise leads to changes in IHL and whether this is accompanied by changes in hepatic ATP. Twenty-one men (age 54.8 ± 7.2 years, BMI 29.7 ± 2.2 kg/m(2)) performed a 2 h cycling protocol, once while staying fasted and once while ingesting glucose. IHL was determined at baseline, 30 min post-exercise and 4 h post-exercise. Additionally ATP/Total P ratio was measured at baseline and 4 h post-exercise. Compared with baseline values we did not observe any statistically significant changes in IHL within 30 min post-exercise in neither the fasted nor the glucose-supplemented condition. However, IHL was elevated 4 h post-exercise compared with baseline in the fasted condition (from 8.3 ± 1.8 to 8.7 ± 1.8%, p = 0.010), an effect that was blunted by glucose supplementation (from 8.3 ± 1.9 to 8.3 ± 1.9%, p = 0.789). Acute exercise does not decrease liver fat in overweight middle-aged men. Moreover, IHL increased 4 h post-exercise in the fasted condition, an increase that was absent in the glucose-supplemented condition. These data suggest that a single bout of exercise may not be able to lower IHL.
authors: 1] NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands [2] Department of Human Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors: L
authors: L
authors: Bilet
authors: 1] NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands [2] Department of Human Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors: B
authors: B
authors: Brouwers
authors: 1] NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands [2] Department of Human Biology, Maastricht University Medical Center, Maastricht, The Netherlands [3] Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors: P A
authors: PA
authors: van Ewijk
authors: 1] NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands [2] Department of Human Movement Sciences, Maastricht University Medical Center, Maastricht, The Netherlands.
authors: M K C
authors: MK
authors: Hesselink
authors: 1] NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands [2] Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands [3] CARIM, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands.
authors: M E
authors: ME
authors: Kooi
authors: 1] NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands [2] Department of Human Biology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors: P
authors: P
authors: Schrauwen
authors: 1] NUTRIM, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands [2] Department of Human Biology, Maastricht University Medical Center, Maastricht, The Netherlands [3] Department of Radiology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors: V B
authors: VB
authors: Schrauwen-Hinderling
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000368:Aged; D004734:Energy Metabolism; D015444:Exercise; D005223:Fats / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism*; D050177:Overweight / Q000378:metabolism*; D010084:Oxidation-Reduction; D012307:Risk Factors
chemical_list: D005223:Fats; D008055:Lipids; D000255:Adenosine Triphosphate