title: The Short-Term Effect of Ketogenic Diet on Carotid Intima-Media Thickness and Elastic Properties of the Carotid Artery and the Aorta in Epileptic Children.
abstract: The aim of this prospective study is to investigate the effect of a 6-month-long ketogenic diet on carotid intima-media thickness, carotid artery, and aortic vascular functions. Thirty-eight drug-resistant epileptic patients who were being treated with ketogenic diet were enrolled. Fasting total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, total cholesterol, and glucose concentrations were measured and echocardiography was performed in all patients before the beginning of ketogenic diet and at the sixth month of treatment. The body weight, height, body mass index, serum levels of triglyceride, total cholesterol, and low-density lipoprotein increased significantly at month 6 when compared to baseline values (P < .05). Carotid intima-media thickness, elastic properties of the aorta, and carotid artery did not change at the sixth month of therapy compared to baseline values. A 6-month-long ketogenic diet has no effect on carotid intima-media thickness and elastic properties of the carotid artery and the aorta.
authors: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey doksozonder@yahoo.com.
authors: Önder
authors: Ö
authors: Doksöz
authors: Department of Pediatric Neurology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Orkide
authors: O
authors: Güzel
authors: Department of Pediatric Neurology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Ünsal
authors: Ü
authors: Yılmaz
authors: Department of Pediatric Intensive Care Unit, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Rana
authors: R
authors: İşgüder
authors: Department of Pediatrics, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Kübra
authors: K
authors: Çeleğen
authors: Department of Pediatric Cardiology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey.
authors: Timur
authors: T
authors: Meşe
authors: Department of Neurology, University of Kansas Medical Center, Kansas, KS, USA.
authors: Utku
authors: U
authors: Uysal
mesh_terms: D000367:Age Factors; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001774:Blood Chemical Analysis; D001794:Blood Pressure; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D002675:Child, Preschool; D055423:Diet, Ketogenic / Q000009:adverse effects; D000069279:Drug Resistant Epilepsy / Q000000981:diagnostic imaging / Q000178:diet therapy* / Q000503:physiopathology*; D004452:Echocardiography; D004548:Elasticity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
keywords: carotid intima-media thickness; children; epilepsy; ketogenic diet; vascular functions