title: Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents.
abstract: In this study, multi-layered pH-responsive polymeric nanoparticles (NPs) are prepared by multiple (up to 4) emulsifications to encapsulate multiple hydrophilic and hydrophobic theranostic agents for controlled and sequenced release. It is found that the sequence of release of multiple chemotherapeutic agents from the NPs significantly affects their efficacy against cancer cells.
authors: Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA. he.429@osu.edu.
authors: Hai
authors: H
authors: Wang
authors: Shuting
authors: S
authors: Zhao
authors: Pranay
authors: P
authors: Agarwal
authors: Jenna
authors: J
authors: Dumbleton
authors: Jianhua
authors: J
authors: Yu
authors: Xiongbin
authors: X
authors: Lu
authors: Xiaoming
authors: X
authors: He
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis* / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005453:Fluorescence; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013499:Surface Properties; D000068936:Theranostic Nanomedicine / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents; D011108:Polymers