title: Metabolic dysfunction in obese Hispanic women with polycystic ovary syndrome.
abstract: OBJECTIVE
  Are certain ethnic groups with polycystic ovary syndrome (PCOS) at increased risk of metabolic disorders?
  
  
  CONCLUSIONS
  Obese Hispanic women with PCOS are at increased risk of metabolic disorders compared with age- and BMI-matched obese non-Hispanic white women with PCOS in the USA.
  
  
  BACKGROUND
  Ethnic differences in body composition and metabolic risk are well established. PCOS is a common disorder in women of reproductive age and is associated with high rates of insulin resistance, glucose intolerance and dyslipidemia.
  
  
  METHODS
  A cross-sectional observational study was performed at an Academic Medical Center on 60 women of reproductive age with PCOS.
  
  
  METHODS
  Blood was obtained after fasting from 17 Hispanic, 22 non-Hispanic black and 21 non-Hispanic white women with PCOS who were similar in age and BMI. Anthropometric parameters, insulin, lipid and lipoprotein levels (measured by nuclear magnetic resonance) were compared between the three groups.
  
  
  RESULTS
  Age and BMI did not differ between the groups. Hispanic women with PCOS had higher waist-to-hip ratio (WHR) (P = 0.02), homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.03) and a more atherogenic lipid and lipoprotein profile consisting of lower high-density lipoprotein (HDL) (P = 0.02), higher low-density lipoprotein (LDL) particle number (P = 0.02), higher very low-density lipoprotein particle (VLDL) size (P = 0.03) and lower LDL (P = 0.03) and HDL particle size (P = 0.005) compared with non-Hispanic white women. The differences in HDL, HOMA-IR, VLDL and LDL size did not persist after adjustment for WHR while differences in LDL particle number (P = 0.04) and HDL size (P = 0.01) persisted.
  
  
  CONCLUSIONS
  The sample size for the three groups was small but the findings were still significant. The women were mostly obese so the ethnic differences in metabolic disorders may not apply to non-obese women with PCOS.
  
  
  CONCLUSIONS
  Independent of BMI, obese, reproductive age, Hispanic women with PCOS in the USA had a greater degree of abdominal obesity, insulin resistance and dyslipidemia. Hispanic women with PCOS may benefit from more focused management of metabolic parameters.
  
  
  BACKGROUND
  This project was supported by the following National Institutes of Health grants: K23 DK080988-01A1 to S.S. and UL1RR029879 to CTSA at University of Illinois. None of the authors report any conflict of interests.
authors: Department of Medicine, Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA ssam@medicine.bsd.uchicago.edu.
authors: Susan
authors: S
authors: Sam
authors: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Illinois, Chicago, IL, USA.
authors: Bert
authors: B
authors: Scoccia
authors: Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois, Chicago, IL, USA.
authors: Sudha
authors: S
authors: Yalamanchi
authors: Department of Medicine, Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, IL, USA Department of Medicine, Northshore University Health System, Chicago, IL, USA.
authors: Theodore
authors: T
authors: Mazzone
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D008659:Metabolic Diseases / Q000150:complications / Q000453:epidemiology*; D009765:Obesity / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: dyslipidemia; high-density lipoprotein particle size; low-density lipoprotein particle number; nuclear magnetic resonance; waist-to-hip ratio