title: Hydration and beyond: neuropeptides as mediators of hydromineral balance, anxiety and stress-responsiveness.
abstract: Challenges to body fluid homeostasis can have a profound impact on hypothalamic regulation of stress responsiveness. Deficiencies in blood volume or sodium concentration leads to the generation of neural and humoral signals relayed through the hindbrain and circumventricular organs that apprise the paraventricular nucleus of the hypothalamus (PVH) of hydromineral imbalance. Collectively, these neural and humoral signals converge onto PVH neurons, including those that express corticotrophin-releasing factor (CRF), oxytocin (OT), and vasopressin, to influence their activity and initiate compensatory responses that alleviate hydromineral imbalance. Interestingly, following exposure to perceived threats to homeostasis, select limbic brain regions mediate behavioral and physiological responses to psychogenic stressors, in part, by influencing activation of the same PVH neurons that are known to maintain body fluid homeostasis. Here, we review past and present research examining interactions between hypothalamic circuits regulating body fluid homeostasis and those mediating behavioral and physiological responses to psychogenic stress.
authors: Laboratory of Dr. Eric Krause, Department of Pharmacodynamics, College of Pharmacy, University of Florida Gainesville, FL, USA.
authors: Justin A
authors: JA
authors: Smith
authors: Laboratory of Dr. Charles Frazier, Department of Pharmacodynamics, College of Pharmacy, University of Florida Gainesville, FL, USA.
authors: Dipanwita
authors: D
authors: Pati
authors: Laboratory of Dr. Eric Krause, Department of Pharmacodynamics, College of Pharmacy, University of Florida Gainesville, FL, USA.
authors: Lei
authors: L
authors: Wang
authors: Laboratory of Dr. Colin Sumners, Department of Physiology and Functional Genomics, College of Medicine, University of Florida Gainesville, FL, USA.
authors: Annette D
authors: AD
authors: de Kloet
authors: Laboratory of Dr. Charles Frazier, Department of Pharmacodynamics, College of Pharmacy, University of Florida Gainesville, FL, USA.
authors: Charles J
authors: CJ
authors: Frazier
authors: Laboratory of Dr. Eric Krause, Department of Pharmacodynamics, College of Pharmacy, University of Florida Gainesville, FL, USA.
authors: Eric G
authors: EG
authors: Krause
keywords: angiotensin; anxiety; hypernatremia; hypothalamic-pituitary-adrenal axis; oxytocin; paraventricular nucleus; post-traumatic stress disorder; stress