title: Searching for predictors of surgical complications in critically ill surgery patients in the intensive care unit: a review.
abstract: We reviewed the use of the levels of C-reactive protein, lactate and procalcitonin and/or the Sequential Organ Failure Assessment score to determine their diagnostic accuracy for predicting surgical complications in critically ill general post-surgery patients. Included were all studies published in PubMed from inception to July 2013 that met the following inclusion criteria: evaluation of the above parameters, describing their diagnostic accuracy and the risk stratification for surgical complications in surgical patients admitted to an intensive care unit. No difference in the Sequential Organ Failure Assessment scores was seen between patients with or without complications. The D-lactate levels were significantly higher in those who developed colonic ischemic complications after a ruptured abdominal aortic aneurysm. After gastro-intestinal surgery, contradictory data were reported, with both positive and negative use of C-reactive protein and procalcitonin in the diagnosis of septic complications. However, in trauma patients, the C-reactive protein levels may help to discriminate between those with and without infectious causes. We conclude that the Sequential Organ Failure Assessment score, lactate concentration and C-reactive protein level have no significant predictive value for early postoperative complications in critically ill post-surgery patients. However, procalcitonin seems to be a useful parameter for diagnosing complications in specific patient populations after surgery and/or after trauma.
authors: Department of Surgery, Amphia Hospital, Molengracht 21, 4818, Breda, CK, The Netherlands, zienalove@hotmail.com.
authors: Zainna C
authors: ZC
authors: Meyer
authors: Jennifer M J
authors: JM
authors: Schreinemakers
authors: Ruud A L
authors: RA
authors: de Waal
authors: Lijckle
authors: L
authors: van der Laan
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D016638:Critical Illness; D005544:Forecasting; D006801:Humans; D007362:Intensive Care Units; D019344:Lactic Acid / Q000097:blood; D063305:Organ Dysfunction Scores; D011183:Postoperative Complications / Q000175:diagnosis*; D011498:Protein Precursors / Q000097:blood*; D039781:PubMed; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D019344:Lactic Acid; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide