title: A current overview of the Papaya meleira virus, an unusual plant virus.
abstract: Papaya meleira virus (PMeV) is the causal agent of papaya sticky disease, which is characterized by a spontaneous exudation of fluid and aqueous latex from the papaya fruit and leaves. The latex oxidizes after atmospheric exposure, resulting in a sticky feature on the fruit from which the name of the disease originates. PMeV is an isometric virus particle with a double-stranded RNA (dsRNA) genome of approximately 12 Kb. Unusual for a plant virus, PMeV particles are localized on and linked to the polymers present in the latex. The ability of the PMeV to inhabit such a hostile environment demonstrates an intriguing interaction of the virus with the papaya. A hypersensitivity response is triggered against PMeV infection, and there is a reduction in the proteolytic activity of papaya latex during sticky disease. In papaya leaf tissues, stress responsive proteins, mostly calreticulin and proteasome-related proteins, are up regulated and proteins related to metabolism are down-regulated. Additionally, PMeV modifies the transcription of several miRNAs involved in the modulation of genes related to the ubiquitin-proteasome system. Until now, no PMeV resistant papaya genotype has been identified and roguing is the only viral control strategy available. However, a single inoculation of papaya plants with PMeV dsRNA delayed the progress of viral infection.
authors: Biotecnologia, Universidade Federal do Espírito Santo, Vitória 29040090, Espírito Santo, Brazil. paollaabreu1@gmail.com.
authors: Paolla M V
authors: PM
authors: Abreu
authors: Biotecnologia, Universidade Federal do Espírito Santo, Vitória 29040090, Espírito Santo, Brazil. tathiana_antunes@hotmail.com.
authors: Tathiana F S
authors: TF
authors: Antunes
authors: Biotecnologia, Universidade Federal do Espírito Santo, Vitória 29040090, Espírito Santo, Brazil. anuar.magana@cicy.mx.|Laboratorio GeMBio, Centro de Investigación Científica de Yucatán A.C., Mérida 97200, Yucatán, Mexico. anuar.magana@cicy.mx.
authors: Anuar
authors: A
authors: Magaña-Álvarez
authors: Laboratorio GeMBio, Centro de Investigación Científica de Yucatán A.C., Mérida 97200, Yucatán, Mexico. daisypb@cicy.mx.
authors: Daisy
authors: D
authors: Pérez-Brito
authors: Laboratorio GeMBio, Centro de Investigación Científica de Yucatán A.C., Mérida 97200, Yucatán, Mexico. rtapia@cicy.mx.
authors: Raúl
authors: R
authors: Tapia-Tussell
authors: Biotecnologia, Universidade Federal do Espírito Santo, Vitória 29040090, Espírito Santo, Brazil. ventura@incaper.es.gov.br.|Instituto Capixaba de Pesquisa, Assistência Técnica e Extensão Rural, Vitória 29050790, Espírito Santo, Brazil. ventura@incaper.es.gov.br.
authors: José A
authors: JA
authors: Ventura
authors: Biotecnologia, Universidade Federal do Espírito Santo, Vitória 29040090, Espírito Santo, Brazil. alberto.fernandes@ufes.br.
authors: Antonio A R
authors: AA
authors: Fernandes
authors: Biotecnologia, Universidade Federal do Espírito Santo, Vitória 29040090, Espírito Santo, Brazil. patricia.fernandes@ufes.br.
authors: Patricia M B
authors: PM
authors: Fernandes
mesh_terms: D029441:Carica / Q000276:immunology / Q000821:virology*; D016679:Genome, Viral; D054884:Host-Pathogen Interactions; D010935:Plant Diseases / Q000276:immunology / Q000821:virology*; D010942:Plant Viruses / Q000235:genetics* / Q000502:physiology*; D012328:RNA Viruses / Q000235:genetics* / Q000502:physiology*