title: Clinical research on neuroblastoma based on serum lactate dehydrogenase.
abstract: In recent years, more and more scholars tend to study neuroblastoma (NB) since it possesses increasing morbidity, but lack of effective treatment. This paper aims to investigate variation and clinical significance of the neuron-specific enolase (NSE) and lactic dehydrogenase (LDH) level in serum of children with NB before and after Auto Peripheral Blood Stem Cell Transplantation (APBSCT). A total of 90 children with NB from various hospitals were included in this research, and we analyzed the relationship between levels of NSE and LDH and the change of disease by comparing the two levels before and after APBSCT treatment. The results indicated that the positive rate of NSE in serum was high before treatment, and the levels of NSE and LDH were remarkably higher than those when the treatment was valid; after comprehensive treatment of chemotherapy, excision and radiotherapy, there was a significant difference of NSE and LDH levels in serum between children with complete remission (CR) and those with partial remission (PR); however, no significant differences of NSE and LDH levels were found among children in progressive stage compared to before treatment. It is believed that NSE and LDH levels are associated to the recurrence and treatment effect of NB, proving that both can reflect tumor load, therefore they can be taken as the auxiliary indicators for monitoring curative effects of NB treatment.
authors: Pediatric Department, Qilu Hospital of Shandong University, Jinan, China.
authors: Q M
authors: QM
authors: Pang
authors: Department of Gynaecology and Obstetrics, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, China.
authors: K
authors: K
authors: Li
authors: Pediatric Department, Zibo Central Hospital, Zibo, China.
authors: L J
authors: LJ
authors: Ma
authors: Pediatric Department, Qilu Hospital of Shandong University, Jinan, China.
authors: R P
authors: RP
authors: Sun
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D009364:Neoplasm Recurrence, Local; D009447:Neuroblastoma / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011237:Predictive Value of Tests; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D007770:L-Lactate Dehydrogenase; D010751:Phosphopyruvate Hydratase