title: Virus-induced preferential antibody gene-usage and its importance in humoral autoimmunity.
abstract: It is known that even the adaptive components of the immune system are based on genetic traits common to all individuals, and that diversity is shaped by the lifelong contacts with different non-self antigens, including those found on infectious pathogens. Besides the individual differences, some of these common traits may be more prone to react against a given antigen, and this may be exploited by the infectious pathogens. Indeed, viral infections can deregulate immune response by subverting antibody (Ab) gene usage, leading to the overexpression of specific Ab subfamilies. This overexpression often results in a protective antiviral response but, in some cases, also correlates with a higher likelihood of developing humoral autoimmune disorders. These aspects of virus-induced autoimmunity have never been thoroughly reviewed, and this is the main purpose of this review. An accurate examination of virus specific Ab subfamilies elicited during infections may help further characterize the complex interplay between viruses and the humoral immune response, and be useful in the design of future monoclonal antibody (mAb)-based anti-infective prophylactic and therapeutic strategies.
authors: Laboratory of Microbiology and Virology, Università "Vita-Salute" San Raffaele, Milano, Italy.
authors: Francesca
authors: F
authors: Cappelletti
authors: Laboratory of Microbiology and Virology, Università "Vita-Salute" San Raffaele, Milano, Italy.
authors: Nicola
authors: N
authors: Clementi
authors: Laboratory of Microbiology and Virology, Università "Vita-Salute" San Raffaele, Milano, Italy.
authors: Nicasio
authors: N
authors: Mancini
authors: Laboratory of Microbiology and Virology, Università "Vita-Salute" San Raffaele, Milano, Italy.
authors: Massimo
authors: M
authors: Clementi
authors: Laboratory of Microbiology and Virology, Università "Vita-Salute" San Raffaele, Milano, Italy. Electronic address: burioni.roberto@hsr.it.
authors: Roberto
authors: R
authors: Burioni
mesh_terms: D000914:Antibodies, Viral / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D014777:Virus Diseases / Q000150:complications / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral
keywords: Antibody gene-usage; Antibody germline; Catalytic antibodies; Humoral autoimmunity; Pathogen-driven gene-usage