title: A bivalent cationic dye enabling selective photo-inactivation against Gram-negative bacteria.
abstract: A piperazine-modified Crystal Violet was found to be able to selectively inactivate Gram-negative bacteria upon visible light irradiation but left Gram-positive bacteria less damaged, which can serve as a blueprint for the development of novel narrow-spectrum agents to replenish the current arsenal of photodynamic antimicrobial chemotherapy (PACT).
authors: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. xswang@mail.ipc.ac.cn zhouqianxiong@mail.ipc.ac.cn.
authors: Ke
authors: K
authors: Li
authors: Yang-Yang
authors: YY
authors: Zhang
authors: Guo-Yu
authors: GY
authors: Jiang
authors: Yuan-Jun
authors: YJ
authors: Hou
authors: Bao-Wen
authors: BW
authors: Zhang
authors: Qian-Xiong
authors: QX
authors: Zhou
authors: Xue-Song
authors: XS
authors: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D002412:Cations / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D005840:Gentian Violet / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects; D006090:Gram-Negative Bacteria / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D006094:Gram-Positive Bacteria / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D008027:Light; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D055668:Photochemical Processes; D010778:Photochemotherapy; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002412:Cations; D010879:Piperazines; D000077489:Piperazine; D005840:Gentian Violet