title: Critical evaluation of a prospective study of concurrent chemoradiotherapy with S-1 for early glottic carcinoma.
abstract: OBJECTIVE
  To improve the outcomes of radiotherapy alone for T2 glottic carcinoma (GC), we initiated a prospective study of concurrent chemoradiotherapy with S-1 for patients with early GC, primarily T2 cases. We report the efficacy and safety of this protocol.
  
  
  METHODS
  Eligible patients had T1b or T2 glottic squamous cell carcinomas. Patients received S-1 (55.3 mg/m(2)/day, once daily) and radiotherapy (2 Gy/day, five days/week, to a total of 30 fractions).
  
  
  RESULTS
  Thirteen patients were eligible. Complete responses were observed in all 13 patients (100%). At a median follow-up duration of 53 months (range=23-68 months), the 3-year local control and overall survival rates were both 100%. Grade 3 dermatitis occurred in only one patient.
  
  
  CONCLUSIONS
  This chemoradiotherapy protocol is well -tolerated and effective in patients with early glottic carcinoma. Furthermore, due to its once-daily administration, this protocol is considered to be easier than usual chemoradiotherapy, and makes outpatient-treatment possible.
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, Japan nishicherry@med.nagoya-u.ac.jp.
authors: Kana
authors: K
authors: Kimura
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Yoshiyuki
authors: Y
authors: Itoh
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Tohru
authors: T
authors: Okada
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Rie
authors: R
authors: Nakahara
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Mariko
authors: M
authors: Kawamura
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Seiji
authors: S
authors: Kubota
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Junji
authors: J
authors: Itoh
authors: Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Mariko
authors: M
authors: Hiramatsu
authors: Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Yasushi
authors: Y
authors: Fujimoto
authors: Department of Clinical Oncology and Chemotherapy, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Takashi
authors: T
authors: Shibata
authors: Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, Japan.
authors: Shinji
authors: S
authors: Naganawa
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005260:Female; D005931:Glottis / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000008:administration & dosage; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid
keywords: Head and neck cancer; S-1; concur rent chemoradiotherapy; early glottic cancer; phase I/II study; prospective study; radiosentitizer; recommend dose