title: Association between high serum estradiol levels and delirium among hospitalized elderly women.
abstract: BACKGROUND
  Delirium is a common and serious disorder among hospitalized elderly individuals. We investigated the association between serum estradiol levels and incident delirium.
  
  
  METHODS
  Longitudinal study of 141 women ≥ 70 years old admitted to a tertiary care hospital in Mexico City. All participants underwent a comprehensive geriatric assessment. Blood samples for cortisol and estradiol determination were obtained at hospital admission. Incident delirium was investigated until participants were discharged. Multivariate models were run to test the independent association between estradiol levels and incident delirium.
  
  
  RESULTS
  Twenty-three (16.3%) participants developed delirium. Estradiol levels were higher among women with incident delirium compared with non-affected women. Multivariate logistic regression analysis showed that serum estradiol levels were associated with incident delirium even after adjusting for multiple confounding covariates, including cortisol levels (OR: 1.93; 95% CI: 1.28-2.92).
  
  
  CONCLUSIONS
  Elderly women with high serum estradiol levels at hospital admission had an increased risk for incident delirium. Serum estradiol may be a biomarker for increased risk of delirium.
authors: Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: José Alberto
authors: JA
authors: Avila-Funes
authors: Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Juan Pablo
authors: JP
authors: Ledesma-Heyer
authors: Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Ana Patricia
authors: AP
authors: Navarrete-Reyes
authors: Laboratory of Steroid Hormones, Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Roberto
authors: R
authors: Chavira-Ramírez
authors: Laboratory of Steroid Hormones, Department of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Lourdes
authors: L
authors: Boeck-Quirasco
authors: Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México D.F., Mexico.
authors: Sara
authors: S
authors: Aguilar-Navarro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003693:Delirium / Q000097:blood / Q000453:epidemiology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D015577:Geriatric Assessment; D006760:Hospitalization; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D016015:Logistic Models; D008137:Longitudinal Studies; D008800:Mexico; D015999:Multivariate Analysis; D012307:Risk Factors
chemical_list: D004958:Estradiol; D006854:Hydrocortisone