title: Divergent synthesis of chiral heterocycles via sequencing of enantioselective three-component reactions and one-pot subsequent cyclization reactions.
abstract: A highly efficient sequencing of catalytic asymmetric three-component reactions of alcohols, diazo compounds and aldimines/aldehydes with one-pot subsequent cyclization reactions was reported. The development of a robust and versatile Rh(ii)/Zr(iv)-BINOL co-catalytic system not only gives high diastereo- and enantioselective controls of the three-component reaction, but also shows excellent functionality tolerances that allow a wide range of functionalities to be pre-installed in each component and readily undergo one-pot subsequent cyclization reactions, thus providing rapid and diversity-oriented synthesis (DOS) of different types of chiral nitrogen- and/or oxygen-containing polyfunctional heterocycles.
authors: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Chemical Engineering, East China Normal University, Shanghai, 200062, China. dxing@sat.ecnu.edu.cn whu@chem.ecnu.edu.cn.
authors: Min
authors: M
authors: Tang
authors: Dong
authors: D
authors: Xing
authors: Haoxi
authors: H
authors: Huang
authors: Wenhao
authors: W
authors: Hu
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000737:chemistry*; D009284:Naphthols / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry
chemical_list: D000438:Alcohols; D000447:Aldehydes; D001391:Azo Compounds; C406944:BINOL, naphthol; D006571:Heterocyclic Compounds; D009284:Naphthols; D012428:Ruthenium; D015040:Zirconium