title: Late onset tacrolimus-induced life-threatening polyneuropathy in a kidney transplant recipient patient.
abstract: A 59-year-old kidney recipient was diagnosed with a late onset of severe chronic inflammatory demyelinating polyradiculoneuropathy and almost fully recovered after stopping tacrolimus and one course of intravenous immunoglobulin treatment. Unique features of this patient are the unusually long time lapse between initiation of tacrolimus and the adverse effect (10 years), a strong causality link and several arguments pointing toward an inflammatory etiology. When facing new neurological signs and symptoms in graft recipients, it is important to bear in mind the possibility of a drug-induced adverse event. Discontinuation of the suspect drug and immunomodulation are useful treatment options.
authors: Division of Clinical Pharmacology , University Hospital of Lausanne , Lausanne , Switzerland.
authors: Delphine
authors: D
authors: Renard
authors: Riviera Hospital , Vevey , Switzerland.
authors: Thierry
authors: T
authors: Gauthier
authors: Transplantation Center , University Hospital of Lausanne , Lausanne , Switzerland.
authors: Jean-Pierre
authors: JP
authors: Venetz
authors: Division of Clinical Pharmacology , University Hospital of Lausanne , Lausanne , Switzerland.
authors: Thierry
authors: T
authors: Buclin
authors: Division of Neurology , University Hospital of Lausanne , Lausanne , Switzerland.
authors: Thierry
authors: T
authors: Kuntzer
keywords: adverse event; chronic inflammatory demyelinating polyradiculoneuropathy; tacrolimus