title: Glomerular damage in experimental proliferative glomerulonephritis under glomerular capillary hypertension.
abstract: OBJECTIVE
  Immunologically and hemodynamically mediated the destruction of glomerular architecture is thought to be the major causes of end-stage renal failure. The purpose of this study is to evaluate the effect of glomerular hypertension on glomerular injury and the progression of glomerular sclerosis after Thy-1 nephritis was induced.
  
  
  METHODS
  Thy-1 nephritis was induced in the stroke-prone spontaneously hypertensive rat strain (SHR-SP) (group SP) and in age-matched Wistar-Kyoto (WKY) (group WKY) rats, following unilateral nephrectomy (UNX), and a vehicle was injected alone in UNX SHR-SP as control (group SC).
  
  
  RESULTS
  The degree of glomerular damage in response to a single dose of anti-thy-1 antibody, and its functional consequences (eg. proteinuria, diminished GFR) are more pronounced in group SP than normotensive group WKY and hypertensive group SC without mesangial cell injury. While normotensive group WKY rats recovered completely from mesangial cell injury on day 28-42, glomeruli in group SP kept on persistent macrophage infiltration, α-SMA expression on day 42-56. In addition, glomerular capillary repair with the GECs was rarely seen in pronouncedly proliferative and sclerostic areas. The incidence of glomerular sclerosis and the level of proteinuria were markedly increased by day 56 in the group SP.
  
  
  CONCLUSIONS
  Our results demonstrate that glomerular hypertension aggravate glomerular damage and glomerulosclerosis in this model of Thy 1 nephritis.
authors: Department of Pediatrics, Second Hospital of Shandong University, Jinan, PR China.
authors: Pei-Rong
authors: PR
authors: Wang
authors: Hiroshi
authors: H
authors: Kitamura
authors: Akira
authors: A
authors: Shimizu
authors: Nobuaki
authors: N
authors: Yamanaka
mesh_terms: D000818:Animals; D002196:Capillaries / Q000473:pathology; D018450:Disease Progression; D005921:Glomerulonephritis / Q000473:pathology*; D006439:Hemodynamics / Q000502:physiology; D006978:Hypertension, Renovascular / Q000139:chemically induced / Q000473:pathology*; D007518:Isoantibodies; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D009392:Nephrectomy; D011507:Proteinuria / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
chemical_list: D007518:Isoantibodies; C035678:anti-Thy antibody