title: Deep brain stimulation for psychiatric disorders: Are nucleus accumbens and medial forebrain bundle two branches of the same tree?
abstract: Purpose of this commentary is to discuss the relation of the nucleus accumbens (NA) with the medial forebrain bundle (MFB) and compare them as deep brain stimulation (DBS) targets in psychiatric disorders. Could a "bundle" be a more effective target than a "nucleus"? Or, more correctly, could an important "modulator" be a more effective target than a highly significant "pleasure center"? The answer hides in the fact that NA is a key component of the MFB. Thus NA dysfunction is synonym to MFB dysfunction. The NA is a "hot-spot" in the neurocircuitry of psychiatric disorders and further experimental investigation is needed for the MFB as a target for neuromodulation in depression, as well as to optimize benefit of psychiatric patients from neuromodulation treatment efforts. Are the NA and MFB two branches of the same tree? They definitely could be, particularly if the "tree" is the brain's "motivation super-system".
authors: Department of Neurosurgery, 'K.A.T.-N.R.C.' General Hospital of Attica, Athens, Greece. Electronic address: pap-van@otenet.gr.
authors: Ioannis N
authors: IN
authors: Mavridis
mesh_terms: D000818:Animals; D046690:Deep Brain Stimulation / Q000379:methods*; D004558:Electric Stimulation / Q000379:methods*; D008474:Medial Forebrain Bundle / Q000503:physiopathology*; D001523:Mental Disorders / Q000503:physiopathology* / Q000628:therapy*
keywords: Deep brain stimulation; Depression; Medial forebrain bundle; Nucleus accumbens; Psychiatric disorders