title: [Cefodizime increases peripheral blood CD4/CD8 and Th1/Th2 ratios in senile patients with bacterial pneumonia].
abstract: OBJECTIVE
  To explore the influence of cefodizime on CD4/CD8 and T helper 1(Th1)/Th2 cell ratios in peripheral blood of the senile patients with bacterial pneumonia.
  
  
  METHODS
  Sixty-three senile patients with bacterial pneumonia were enrolled and divided into two groups randomly. Patients in the control group (n=31) were given intravenous infusion of ceftriaxone sodium, and patients in the observation group (n=32) were given intravenous infusion of cefodizime. The fasting venous blood was taken before and after treatment to detect CD4/CD8 and Th1/Th2 cell ratios with flow cytometry. At the same time, the serum interleukin-2 (IL-2), interferon γ (IFN-γ), IL-4 and IL-10 contents were also detected with ELISA.
  
  
  RESULTS
  Before treatment, there was no significant difference in the above indexes between the two groups. After treatment, CD4⁺ cells and Th1 cells of the observation group increased while Th2 cells decreased; as a result, the CD4/CD8 and Th1/Th2 cell ratios of the observation group were significantly higher than those of the control group. At the same time, serum IL-2 and IFN-γ contents of the observation group were significantly higher than those of the control group, while serum IL-4 and IL-10 contents were significantly lower than those of the control group.
  
  
  CONCLUSIONS
  Cefodizime can improve the cellular immune function and rectify CD4/CD8 and Th1/Th2 imbalance in peripheral blood of the senile patients with bacterial pneumonia.
authors: Department of Pharmaceutics, Affiliated Hospital, Binzhou Medical College, Binzhou 256600, China.
authors: Bin
authors: B
authors: Wang
authors: Department of Pharmaceutics, Affiliated Hospital, Binzhou Medical College, Binzhou 256600, China.
authors: Ruimin
authors: R
authors: Bian
authors: Department of Pharmaceutics, Affiliated Hospital, Binzhou Medical College, Binzhou 256600, China.
authors: Chuanmei
authors: C
authors: Wei
authors: Department of Pharmaceutics, Affiliated Hospital, Binzhou Medical College, Binzhou 256600, China.
authors: Shaowei
authors: S
authors: Sun
authors: Department of Pharmaceutics, Affiliated Hospital, Binzhou Medical College, Binzhou 256600, China.
authors: Peimin
authors: P
authors: Gao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001772:Blood Cell Count; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology*; D002439:Cefotaxime / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000097:blood* / Q000188:drug therapy*; D018417:Th1 Cells / Q000166:cytology*; D018418:Th2 Cells / Q000166:cytology*
chemical_list: D000900:Anti-Bacterial Agents; D007376:Interleukin-2; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma; D002439:Cefotaxime; C033356:cefodizime