title: An Exploratory Study of the Effects of Mind-Body Interventions Targeting Sleep on Salivary Oxytocin Levels in Cancer Survivors.
abstract: Cancer survivors experience high levels of distress, associated with a host of negative psychological states, including anxiety, depression, and fear of recurrence, which often lead to sleep problems and reduction in quality of life (QOL) and well-being. As a neuropeptide hormone associated with affiliation, calmness, and well-being, oxytocin may be a useful biological measure of changes in health outcomes in cancer survivors. In this exploratory study, which comprised a subset of participants from a larger study, we evaluated (a) the feasibility and reliability of salivary oxytocin (sOT) levels in cancer survivors and (b) the effects of 2 sleep-focused mind-body interventions, mind-body bridging (MBB) and mindfulness meditation (MM), compared with a sleep hygiene education (SHE) control, on changes in sOT levels in 30 cancer survivors with self-reported sleep disturbance. Interventions were conducted in 3 sessions, once per week for 3 weeks. Saliva samples were collected at baseline, postintervention (~1 week after the last session), and at the 2-month follow-up. In this cancer survivor group, we found that intra-individual sOT levels were fairly stable across the 3 time points, of about 3 months' duration, and mean baseline sOT levels did not differ between females and males and were not correlated with age. Correlations between baseline sOT and self-report measures were weak; however, several of these relationships were in the predicted direction, in which sOT levels were negatively associated with sleep problems and depression and positively associated with cancer-related QOL and well-being. Regarding intervention effects on sOT, baseline-subtracted sOT levels were significantly larger at postintervention in the MBB group as compared with those in SHE. In this sample of cancer survivors assessed for sOT, at postintervention, greater reductions in sleep problems were noted for MBB and MM compared with that of SHE, and increases in mindfulness and self-compassion were observed in the MBB group compared with those in SHE. The findings in this exploratory study suggest that sOT may be a reliable biological measure over time that may provide insight into the effects of mind-body interventions on health outcomes in cancer survivors.
authors: University of Utah, Salt Lake City, UT, USA dll3@utah.edu.
authors: David L
authors: DL
authors: Lipschitz
authors: University of Utah, Salt Lake City, UT, USA.
authors: Renee
authors: R
authors: Kuhn
authors: University of New Mexico, Albuquerque, NM, USA.
authors: Anita Y
authors: AY
authors: Kinney
authors: University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
authors: Karen
authors: K
authors: Grewen
authors: University of Utah, Salt Lake City, UT, USA.
authors: Gary W
authors: GW
authors: Donaldson
authors: University of Utah, Salt Lake City, UT, USA.
authors: Yoshio
authors: Y
authors: Nakamura
mesh_terms: D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D019122:Meditation / Q000379:methods; D008875:Middle Aged; D026441:Mind-Body Therapies / Q000379:methods*; D064866:Mindfulness / Q000379:methods; D009369:Neoplasms / Q000523:psychology / Q000534:rehabilitation*; D010121:Oxytocin / Q000378:metabolism*; D011446:Prospective Studies; D011788:Quality of Life; D015203:Reproducibility of Results; D012463:Saliva / Q000737:chemistry; D012893:Sleep Wake Disorders / Q000209:etiology / Q000628:therapy*; D017741:Survivors; D013997:Time Factors
chemical_list: D010121:Oxytocin
keywords: cancer survivor; mind–body intervention; oxytocin; salivary hormone; sleep; well-being