title: No association between iron status and self-reported health-related quality of life in 16,375 Danish blood donors: results from the Danish Blood Donor Study.
abstract: BACKGROUND
  Health-related quality of life (HRQL) represents people's subjective assessment of their mental and physical well-being. HRQL is highly predictive of future health. The effect of iron deficiency without anemia induced by blood donation on HRQL is presently unknown. The aim was to explore the relationship between iron status and self-reported mental component score (MCS; SF-12) and physical component score (PCS; SF-12) in Danish blood donors.
  
  
  METHODS
  Complete relevant data, including the 12-item short-form health survey (SF-12), plasma ferritin levels, age, body mass index, smoking status, C-reactive protein levels, number of donations in the previous 3 years, and PCS and MCS, were available for 8692 men and 7683 women enrolled from March 1, 2010, to December 31, 2010. Multivariable linear and logistic (cutoff at the 10th percentile) regression analyses were used to assess the relationship between iron deficiency (ferritin < 15 ng/mL) and MCS and PCS, respectively. Analyses were performed separately for men and women.
  
  
  RESULTS
  There was no significant relationship between iron deficiency and self-reported mental or physical health.
  
  
  CONCLUSIONS
  This study found no association between iron stores and self-reported HRQL among Danish blood donors.
authors: Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
authors: Andreas S
authors: AS
authors: Rigas
authors: Department of Clinical Immunology, Naestved Hospital, Naestved, Denmark.
authors: Ole B
authors: OB
authors: Pedersen
authors: Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
authors: Cecilie J
authors: CJ
authors: Sørensen
authors: Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
authors: Erik
authors: E
authors: Sørensen
authors: Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
authors: Sebastian R
authors: SR
authors: Kotzé
authors: Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
authors: Mikkel S
authors: MS
authors: Petersen
authors: Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
authors: Lise W
authors: LW
authors: Thørner
authors: Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
authors: Henrik
authors: H
authors: Hjalgrim
authors: Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
authors: Christian
authors: C
authors: Erikstrup
authors: Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.
authors: Henrik
authors: H
authors: Ullum
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001782:Blood Donors; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D003718:Denmark; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood*; D000090463:Iron Deficiencies; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D011788:Quality of Life; D057566:Self Report
chemical_list: D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron