title: White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging.
abstract: Many patients with dementia with Lewy bodies (DLB) have overlapping Alzheimer's disease (AD)-related pathology, which may contribute to white matter (WM) diffusivity alterations on diffusion tensor imaging (DTI). Consecutive patients with DLB (n = 30), age- and sex-matched AD patients (n = 30), and cognitively normal controls (n = 60) were recruited. All subjects underwent DTI, 18F 2-fluoro-deoxy-d-glucose, and (11)C Pittsburgh compound B positron emission tomography scans. DLB patients had reduced fractional anisotropy (FA) in the parietooccipital WM but not elsewhere compared with cognitively normal controls, and elevated FA in parahippocampal WM compared with AD patients, which persisted after controlling for β-amyloid load in DLB. The pattern of WM FA alterations on DTI was consistent with the more diffuse posterior parietal and occipital glucose hypometabolism of 2-fluoro-deoxy-d-glucose positron emission tomography in the cortex. DLB is characterized by a loss of parietooccipital WM integrity, independent of concomitant AD-related β-amyloid load. Cortical glucose hypometabolism accompanies WM FA alterations with a concordant pattern of gray and WM involvement in the parietooccipital lobes in DLB.
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Charles University in Prague, 2nd Faculty of Medicine and Motol University Hospital, Prague, The Czech Republic; International Clinical Research Center, St. Anne's University Hospital Brno, Brno, The Czech Republic.
authors: Zuzana
authors: Z
authors: Nedelska
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors: Christopher G
authors: CG
authors: Schwarz
authors: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors: Bradley F
authors: BF
authors: Boeve
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors: Val J
authors: VJ
authors: Lowe
authors: Department of Information Technology, Mayo Clinic, Rochester, MN, USA.
authors: Robert I
authors: RI
authors: Reid
authors: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors: Scott A
authors: SA
authors: Przybelski
authors: Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
authors: Timothy G
authors: TG
authors: Lesnick
authors: Department of Information Technology, Mayo Clinic, Rochester, MN, USA.
authors: Jeffrey L
authors: JL
authors: Gunter
authors: Department of Information Technology, Mayo Clinic, Rochester, MN, USA.
authors: Matthew L
authors: ML
authors: Senjem
authors: Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA.
authors: Tanis J
authors: TJ
authors: Ferman
authors: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
authors: Glenn E
authors: GE
authors: Smith
authors: International Clinical Research Center, St. Anne's University Hospital Brno, Brno, The Czech Republic; Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, AZ, USA; Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA.
authors: Yonas E
authors: YE
authors: Geda
authors: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors: David S
authors: DS
authors: Knopman
authors: Department of Neurology, Mayo Clinic, Rochester, MN, USA.
authors: Ronald C
authors: RC
authors: Petersen
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA.
authors: Clifford R
authors: CR
authors: Jack
authors: Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: kantarci.kejal@mayo.edu.
authors: Kejal
authors: K
authors: Kantarci
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016880:Anisotropy; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D020961:Lewy Body Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000378:metabolism; D049268:Positron-Emission Tomography; D066127:White Matter / Q000473:pathology*
chemical_list: D016229:Amyloid beta-Peptides; D005947:Glucose
keywords: Amyloid-beta load; Cortical hypometabolism; Dementia with Lewy bodies; Diffusion tensor imaging; Voxel-based analysis; White matter integrity