title: [The immunohistochemical features of ovarian serous adenocarcinoma cells, which determine a disease course and survival rates in patients].
abstract: OBJECTIVE
  To study a relationship of survival rates to the expression of major genes (p53, PTEN, COX2, pRb and others) involved in the pathogenesis of ovarian cancer.
  
  
  METHODS
  The trial enrolled 23 patients with Stages III-IV ovarian serous adenocarcinoma. Of them, 11 patients showed a long overall survival (median 50 ± 2.5 months), 12 did a short one (14.5 ± 0.7 months). Ovarian adenocarcinomas were high- and low-grade in 20 (87%) and 3 (13%) cases, respectively.
  
  
  RESULTS
  Estimating the relationship of the expression of the examined markers and the prognosis of the disease showed that the expression of p53 and Rb was more common in the patients with a short overall survival (median 14.5 versus 50 months; p = 0.03; p = 0.04).
  
  
  CONCLUSIONS
  The expression of mutant p53 protein and that of retinoblastoma (Rb) gene protein are poor prognostic factors for ovarian serous adenocarcinoma.
authors: Russian Research Center for Radiology and Surgical Technologies, Saint Petersburg.
authors: K M
authors: KM
authors: Pozharissky
authors: Russian Research Center for Radiology and Surgical Technologies, Saint Petersburg.
authors: G A
authors: GA
authors: Raskin
authors: Russian Research Center for Radiology and Surgical Technologies, Saint Petersburg.
authors: V L
authors: VL
authors: Vinokurov
authors: Russian Research Center for Radiology and Surgical Technologies, Saint Petersburg.
authors: L E
authors: LE
authors: Yurkova
authors: Russian Research Center for Radiology and Surgical Technologies, Saint Petersburg.
authors: M S
authors: MS
authors: Mukhina
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology*; D000077216:Carcinoma, Ovarian Epithelial; D018284:Cystadenocarcinoma, Serous / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D016159:Tumor Suppressor Protein p53