title: The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions.
abstract: Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). Therefore drugs targeting VEGFA/VEGFR-2 are being presently used in the clinics for treatment of several types of solid malignant tumours. We here in report that low dose of chebulagic acid (CA), a hydrolysable tannin found in myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, migration, tube formation and thereby, angiogenesis by suppressing VEGFR-2 phosphorylation. CA may thus be an effective and useful natural inhibitor of VEGFA mediated angiogenesis.
authors: Department of Pathology, Ohio State University, Columbus, Ohio 43210, United States of America.
authors: Kai
authors: K
authors: Lu
authors: 1] Department of Pathology, Ohio State University, Columbus, Ohio 43210, United States of America [2] Division of Medical Oncology, Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, United States of America.
authors: Sujit
authors: S
authors: Basu
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000493:pharmacokinetics / Q000494:pharmacology*; D001688:Biological Products / Q000493:pharmacokinetics / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002645:Chickens; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism*; D005960:Glucosides / Q000493:pharmacokinetics / Q000494:pharmacology*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D051379:Mice; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010539:Permeability / Q000187:drug effects; D010766:Phosphorylation; D010936:Plant Extracts / Q000008:administration & dosage; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism
chemical_list: D001578:Benzopyrans; D001688:Biological Products; D005960:Glucosides; D010936:Plant Extracts; D042461:Vascular Endothelial Growth Factor A; C520904:triphala; C076178:chebulagic acid; D040301:Vascular Endothelial Growth Factor Receptor-2