title: Synthesis and antiproliferative activity in vitro of new 2-thioxoimidazo[4,5-B]pyridine derivatives.
abstract: Two series of 2-thioxoimidazo[4,5-b]pyridine derivatives have been synthesized from 2,3-diaminopyridine (1) and 5-halogenosubstituted-2,3-diaminopyridines 2, 3. Mannich bases 7 - 12 and 24 - 29, derivatives of 1-arylamino-6-halogeno-2-thioxoimidazo[4,5-b]pyridine were obtained with selected secondary amines: morpholine, piperidine, 2-methoxyphenylpiperazine, pyrimidyn-2-yl-piperazine and formaldehyde in ethanol. The structures 7 - 12 and 24 - 29 were confirmed by the results of elementary analysis and their IR, 1H-NMR and MS spectra. All given structures 7 - 12 have been optimized to get the most stable low energy conformers. Synthesized compounds were of interest for biological studies or can be substrates for further synthesis. The selected compounds 7 - 10, 12- 17, 22, 25, 27 - 29 were screened for their antiproliferative activity in vitro against human cancer and normal mouse fibroblast cell lines.
authors: Anna
authors: A
authors: Nowicka
authors: Hanna
authors: H
authors: Liszkiewicz
authors: Wanda P
authors: WP
authors: Nawrocka
authors: Joanna
authors: J
authors: Wietrzyk
authors: Agnieszka
authors: A
authors: Zubiak
authors: Wojciech
authors: W
authors: Kołodziejczyk
mesh_terms: D000631:Aminopyridines / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D041702:BALB 3T3 Cells; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000631:Aminopyridines; D011725:Pyridines; C038615:2,3-diaminopyridine; C023666:pyridine