title: Palladium-Catalyzed Dynamic Kinetic Asymmetric Transformation of Racemic Biaryls: Axial-to-Central Chirality Transfer.
abstract: The first dynamic kinetic asymmetric transformation of racemic biaryl substrates on the basis of axial-to-central chirality transfer has been realized. Chiral Pd-NHC complexes were found to catalyze the dynamic kinetic asymmetric spiroannulation of 4-(2-bromoaryl)-naphthalen-1-ols (or 2'-bromo-[1,1'-biphenyl]-4-ols) with internal alkynes, affording a series of enantioenriched spirocyclic products bearing an all-carbon quaternary stereocenter in good yields (up to 95%) with excellent enantioselectivities (up to 97% ee).
authors: Liu
authors: L
authors: Yang
authors: Huayu
authors: H
authors: Zheng
authors: Lei
authors: L
authors: Luo
authors: Jiang
authors: J
authors: Nan
authors: Jingjing
authors: J
authors: Liu
authors: Yaoyu
authors: Y
authors: Wang
authors: Xinjun
authors: X
authors: Luan