title: Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency.
abstract: BACKGROUND
  We aimed herein to investigate the killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles in patients with common variable immunodeficiency (CVID), and to reveal their differences from those in healthy population.
  
  
  METHODS
  In all, 18 patients who have been diagnosed with CVID and 15 living donors of kidney transplant recipients were enrolled in the study. Polymerase chain reaction-sequence-specific primer (PCR-SSP) typing method was used in molecular genetic analysis. The frequencies of the genes in the study groups were statistically compared with each other using chi-square or Fisher exact tests, whichever were appropriate.
  
  
  RESULTS
  Although there was no significant difference between both study groups with respect to distribution of KIR and HLA-C2 group genes, HLA-Cw7 allele frequency in patients with CVID was significantly lower than that in healthy population (P = 0.008).
  
  
  CONCLUSIONS
  This present study results support that HLA-Cw7 allele, an inhibitor of KIR ligand, may play a role in the pathogenesis of CVID.
authors: Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey. okartal@gata.edu.tr.
authors: Ozgur
authors: O
authors: Kartal
authors: Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey.
authors: Ugur
authors: U
authors: Musabak
authors: Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey.
authors: Sait
authors: S
authors: Yesillik
authors: Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey.
authors: Rahsan I
authors: RI
authors: Sagkan
authors: Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey.
authors: Aysel
authors: A
authors: Pekel
authors: Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey.
authors: Fevzi
authors: F
authors: Demirel
authors: Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey.
authors: Abdullah
authors: A
authors: Baysan
authors: Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey.
authors: Ali
authors: A
authors: Selçuk
authors: Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey.
authors: Mustafa
authors: M
authors: Güleç
authors: Division of Immunology and Allergic Diseases, Gulhane Military Medical Academy and School of Medicine, 06018, Ankara, Turkey.
authors: Osman
authors: O
authors: Şener
mesh_terms: D000328:Adult; D017074:Common Variable Immunodeficiency / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D054340:Receptors, KIR / Q000235:genetics* / Q000276:immunology*; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D005819:Genetic Markers; D015236:HLA-C Antigens; D054340:Receptors, KIR
keywords: Common variable immunodeficiency; Human leukocyte antigen-C alleles; Killer-cell immunoglobulin-like receptor