title: Surface characterization and drug release from porous microparticles based on methacrylic monomers and xanthan.
abstract: Porous crosslinked microparticles based on glycidyl methacrylate and xanthan were prepared by suspension polymerization and used for loading theophylline, a bronhodilatator drug, in order to obtain new drug delivery systems. The surface morphologies observed by means of SEM and AFM analysis demonstrated that microparticles show a spherical shape and are characterized by a porous structure. The presence of xanthan in the structure of microparticles leads to a decrease of surface roughness and pore diameters as well as to an increase of hydrophilicity degree compared to the micropaticles based only on glycidyl methacrylate. To analyze the in vitro release data various mathematical models were used, such as, first order, Higuchi model, Korsmeyer-Peppas model and Baker-Lonsdale model. Based on the highest values of the correlation coefficient, the analysis of the kinetic data indicate that drug release from G1 and X1 porous microparticles fits similarly well to the first order and Higuchi models and diffusion was the dominant mechanism of drug release.
authors: "Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Department of Natural and Synthetic Polymers, Prof. Dr. Docent Dimitrie Mangeron Street, No. 73, 700050, Iasi, Romania; "Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No. 41A, 700487 Iasi, Romania. Electronic address: maria_andreea.lungan@yahoo.com.
authors: Maria-Andreea
authors: MA
authors: Lungan
authors: "Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Department of Natural and Synthetic Polymers, Prof. Dr. Docent Dimitrie Mangeron Street, No. 73, 700050, Iasi, Romania. Electronic address: marpopa2001@yahoo.fr.
authors: Marcel
authors: M
authors: Popa
authors: "Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No. 41A, 700487 Iasi, Romania. Electronic address: stefania.racovita@icmpp.ro.
authors: Stefania
authors: S
authors: Racovita
authors: "Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No. 41A, 700487 Iasi, Romania. Electronic address: gabrielahitruc@yahoo.com.
authors: Gabriela
authors: G
authors: Hitruc
authors: "Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No. 41A, 700487 Iasi, Romania. Electronic address: florica.doroftei@icmpp.ro.
authors: Florica
authors: F
authors: Doroftei
authors: Pau and Pays de l'Adour University (UPPA), Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Materiaux (IPREM/EPCP), UMR CNRS 5254, Helioparc Pau Pyrenees, 2, av. President Angot, 64053 Pau Cedex 09, France. Electronic address: jacques.desbrieres@univ-pau.fr.
authors: Jacques
authors: J
authors: Desbrieres
authors: "Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No. 41A, 700487 Iasi, Romania. Electronic address: msilvia@icmpp.ro.
authors: Silvia
authors: S
authors: Vasiliu
mesh_terms: D065546:Drug Liberation; D004852:Epoxy Compounds / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry*; D053769:Nanocapsules / Q000737:chemistry / Q000648:ultrastructure*; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D016062:Porosity; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D004852:Epoxy Compounds; D008689:Methacrylates; D053769:Nanocapsules; D011135:Polysaccharides, Bacterial; D013806:Theophylline; C007870:glycidyl methacrylate; C002563:xanthan gum
keywords: Methacrylic monomers; Porous microparticles; Surface morphology; Theophylline; Xanthan