title: Full-mouth ultrasonic debridement associated with povidone iodine rinsing in GAgP treatment: a randomised clinical trial.
abstract: OBJECTIVE
  This study evaluated the clinical, immunological and microbiological results of full-mouth ultrasonic debridement (FMUD) with 10 % povidone iodine (PVPI) as the cooling liquid in the treatment of generalised aggressive periodontitis (GAgP).
  
  
  METHODS
  Twenty-eight patients presenting GAgP were randomly assigned to one of the following groups for evaluation: FMUD + SS (n = 14)--single session of FMUD with 0.9 % saline solution as cooling agent and FMUD + PVPI (n = 14)--single session of FMUD with PVPI solution as cooling agent. Probing depth (PD), relative clinical attachment level (RCAL), relative position of gingival margin, plaque index (FMPI) and bleeding score (FMBS), immunological (interleukin-10 and interleukin-1β concentrations in gingival crevicular fluid) and microbiological (Aa and Pg amounts) parameters were evaluated at baseline, first, third and sixth months after treatment.
  
  
  RESULTS
  The two groups presented reduction of FMPI and FMBS and had statistically significant PD reductions, RCAL gains and gingival recession (p < 0.05). Both therapies reduced Pg levels in deep and in moderate pockets (p < 0.05). FMUD + PVPI reduced Aa levels in deep pockets. However, no inter-group differences in clinical, immunological and microbiological parameters were observed (p > 0.05).
  
  
  CONCLUSIONS
  It could be concluded that 10 % PVPI used as an irrigant solution in FMUD decreased Aa levels in deep pockets but had no additional benefits when compared with saline solution irrigation in terms of clinical, microbiological and immunological results.
  
  
  CONCLUSIONS
  The FMUD is a valid option for the treatment of GAgP, but the use of 10 % PVPI did not improve the results of the periodontal therapy.
authors: Division of Periodontics, Amazonas State University, Av. Carvalho Leal 1777, Cachoeirinha, 69065-001, Manaus, AM, Brazil.
authors: Hugo Felipe
authors: HF
authors: do Vale
authors: Division of Periodontics, Piracicaba Dental School, State University of Campinas, UNIP, Av. Limeira 901, 13414-903, Piracicaba, SP, Brazil.
authors: Renato Corrêa Viana
authors: RC
authors: Casarin
authors: Division of Periodontics, Piracicaba Dental School, State University of Campinas, UNIP, Av. Limeira 901, 13414-903, Piracicaba, SP, Brazil.
authors: Tiago
authors: T
authors: Taiete
authors: Division of Biostatistics, Piracicaba Dental School, State University of Campinas, Av. Limeira 901, 13414-903, Piracicaba, SP, Brazil.
authors: Gláucia Maria
authors: GM
authors: Bovi Ambrosano
authors: Division of Periodontics, Piracicaba Dental School, State University of Campinas, UNIP, Av. Limeira 901, 13414-903, Piracicaba, SP, Brazil.
authors: Karina Gonzales Silvério
authors: KG
authors: Ruiz
authors: Division of Periodontics, Piracicaba Dental School, State University of Campinas, UNIP, Av. Limeira 901, 13414-903, Piracicaba, SP, Brazil.
authors: Francisco Humberto
authors: FH
authors: Nociti
authors: Division of Periodontics, Piracicaba Dental School, State University of Campinas, UNIP, Av. Limeira 901, 13414-903, Piracicaba, SP, Brazil.
authors: Enílson Antônio
authors: EA
authors: Sallum
authors: Division of Periodontics, Piracicaba Dental School, State University of Campinas, UNIP, Av. Limeira 901, 13414-903, Piracicaba, SP, Brazil. casati@fop.unicamp.br.
authors: Márcio Zaffalon
authors: MZ
authors: Casati
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D057747:Periodontal Debridement / Q000379:methods*; D011206:Povidone-Iodine / Q000627:therapeutic use*; D016896:Treatment Outcome; D014464:Ultrasonic Therapy
chemical_list: D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine
keywords: Aggressive periodontitis; Full-mouth ultrasonic debridement; Non-surgical periodontal therapy; Povidone iodine