title: Development and validation of weight, height and age bands to guide the prescription of fixed-dose dispersible tablet formulations.
abstract: OBJECTIVE
  Conversion of pediatric essential drugs from syrup to dispersible tablet formulations would require fixed dose options guided by the weight band in which a child falls or a proxy for weight, such as height or age. The purpose of this study was to determine whether weight, height, or age bands can be created that would lead to greater than 95% of children receiving a therapeutic dose of 6 commonly prescribed essential drugs, including paracetamol, iron sulfate, amoxicillin, co-trimoxazole (i.e., trimethoprim/sulfamethoxazole), ciprofloxacin, and co-artemether (i.e., artemether/lumefantrine).
  
  
  METHODS
  Using World Health Organization growth standards, we created 4 weight bands and then matched them to height and age 50th percentile growth curves. The resulting weight, height, and age bands were then applied to Ugandan and Bangladeshi anthropometric data sets, and the percentage of children who would have received a correct therapeutic dose based upon weight, height, or age was determined. This percentage was interpreted as acceptable if >95%, marginal if 90% to 95% and unacceptable if <90%.
  
  
  RESULTS
  Applying the 4 weight bands to the 6 selected drugs, greater than 95% of children would have received an acceptable therapeutic dose across the 4 weight bands for each of the 6 drugs tested. None of the drugs tested would deliver an acceptable therapeutic dose across all bands based upon height or age among Ugandan children, and only co-trimoxazole would have been delivered at acceptable therapeutic levels based upon these bands in Bangladeshi children.
  
  
  CONCLUSIONS
  For the 6 drugs tested, dispersible tablets prescribed on the basis of a 4-dose regimen determined by weight bands would deliver an acceptable therapeutic dose greater than 95% of the time. Substituting weight for age or height bands would result in unacceptable levels of under- or overdosing.
authors: Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada ; Centre for International Child Health, British Columbia Children's Hospital, Vancouver, British Columbia, Canada ; International Centre of Diarrheal Diseases Research, Bangladesh, Dhaka, Bangladesh ; Child and Family Research Institute, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
authors: Charles P
authors: CP
authors: Larson
authors: Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada ; Centre for International Child Health, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
authors: Laura
authors: L
authors: Sauvé
authors: Department of Pediatrics, Mbarara University of Science and Technology, Mbarara, Uganda.
authors: Jude Kimbowa
authors: JK
authors: Senkungu
authors: Department of Pediatrics, Mbarara University of Science and Technology, Mbarara, Uganda.
authors: Shams El
authors: SE
authors: Arifeen
authors: Child and Family Research Institute, British Columbia Children's Hospital, Vancouver, British Columbia, Canada ; Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada.
authors: Rollin
authors: R
authors: Brant
keywords: IMCI; child health; dispersible tablets; essential drugs; weight