title: Fullerene up-take alters bilayer structure and elasticity: A small angle X-ray study.
abstract: The coupling of fullerene (C60) to the structure and elasticity of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine bilayers has been explored by synchrotron small angle X-ray scattering. Multilamellar vesicles were loaded with 0, 2 and 10 mol.% of C60 and studied in a temperature range from 15 to 65 °C. The addition of C60 caused an increase in the bilayer undulations (∼ 20%), in the bilayer separation (∼ 15%), in the linear expansion coefficient and caused a drop in the bending rigidity of the bilayers (20-40%). Possible damaging effects of fullerene on biomembranes are mainly discussed on the basis of altered bilayer fluidity and elasticity changes.
authors: Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia.
authors: Barbara
authors: B
authors: Drasler
authors: Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia. Electronic address: damjana.drobne@bf.uni-lj.si.
authors: Damjana
authors: D
authors: Drobne
authors: School of Food Science & Nutrition, University of Leeds, Leeds LS2 9JT, UK.
authors: Amin
authors: A
authors: Sadeghpour
authors: School of Food Science & Nutrition, University of Leeds, Leeds LS2 9JT, UK. Electronic address: m.rappolt@leeds.ac.uk.
authors: Michael
authors: M
authors: Rappolt
mesh_terms: D004548:Elasticity; D037741:Fullerenes / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D015394:Molecular Structure; D010316:Particle Size; D053838:Scattering, Small Angle; D013499:Surface Properties; D017356:Synchrotrons; D014961:X-Ray Diffraction
chemical_list: D037741:Fullerenes; D008051:Lipid Bilayers; C069837:fullerene C60
keywords: Bilayer structure; Fullerene; Membrane undulations; POPC; SAXS; Toxicity