title: A Facile Strategy for the Construction of Cyclic Peptoids under Microwave Irradiation through a Simple Substitution Reaction.
abstract: We describe a fast and efficient side chain-to-tail cyclization of N-substituted glycine oligomers, peptoids, on a solid support and under microwave irradiation. We demonstrate that cyclic peptoids varied in their ring size and side chains can be synthesized by a bond formation between a chloropropyl group placed anywhere along the sequence and the secondary amine at the N-terminus. This SN2 reaction leads to the formation of a new C-N bond using only one reagent (a base).
authors: Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, Haifa, 32000, Israel.
authors: Prathap Jeya
authors: PJ
authors: Kaniraj
authors: Schulich Faculty of Chemistry, Technion - Israel Institute of Technology, Haifa, 32000, Israel.
authors: G
authors: G
authors: Maayan
mesh_terms: D003500:Cyclization; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D034444:Peptoids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D034444:Peptoids; D005998:Glycine