title: The granule porosity controls the loss of compactibility for both dry- and wet-processed cellulose granules but at different rate.
abstract: The aim of this study was to investigate the role of porosity on the compression behavior and tablet tensile strength for granules produced by a dry granulation procedure. Microcrystalline cellulose was used as a typical pharmaceutical excipient and a comparison was made with the effect of granule porosity on the compression behavior and tablet tensile strength of wet-processed granules of the same composition. Both the wet and dry granulation process caused a loss in compactibility of the material that was controlled by the granule porosity up to a critical point of porosity and friability. Above this threshold value of porosity, the granules nearly collapsed completely into primary particles during compression. In these cases, the micro-structure and tensile strength of the formed tablets resembled that of tablets formed from the original ungranulated powder.
authors: Department of Pharmacy, Uppsala University Uppsala SE-751 23, Sweden. Electronic address: josefina.nordstrom@farmaci.uu.se.
authors: Josefina
authors: J
authors: Nordström
authors: Department of Pharmacy, Uppsala University Uppsala SE-751 23, Sweden.
authors: Göran
authors: G
authors: Alderborn
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry*; D016062:Porosity; D011208:Powders; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical; D013718:Tensile Strength
chemical_list: D005079:Excipients; D011208:Powders; D013607:Tablets; D002482:Cellulose; C109691:microcrystalline cellulose
keywords: cellulose; compaction; compression; granulation; granules; porosity; powder technology; tableting; tablets; tensile strength