title: A comparison of the molecular distribution of proangiogenic factors in endometrium of missed abortions and of voluntary first trimester termination cases.
abstract: OBJECTIVE
  The authors aimed to evaluate the angiogenic changes that occur in the cases with missed abortions compared with the voluntary termination of pregnancy as control group, with this controlled clinical study.
  
  
  METHODS
  The study included fifteen healthy volunteer women with unwanted pregnancy less than 10th gestational week in an academic research environment. The patients were 19 women between 6th and 11th gestational weeks diagnosed with missed abortion as the patient group. Immunohistochemistry was utilized to examine temporal and spatial expression of vascular endothelial growth factor (VEGF) and their two receptors: VEGF-R1 (Flt-1) and VEGF-R2 (Flk-1/KDR), and Trombospondin-1, eNOS, iNOS, and HIF-1α in the both deciduas and placenta of the both groups.
  
  
  RESULTS
  This study discovered the significant difference (p < 0.005) between the groups of controlled and missed abortion in the decidual and placental cell components, and has put forward that thrombospondin and iNOS have an impact on abortion through antiangiogenic effect in cases of missed abortions.
  
  
  CONCLUSIONS
  The potential role of molecules affecting angiogenesis in the etiology of missed abortion has been evaluated and the authors aimed for this to be a guide for studies on further treatments and on the prevention of the development of missed abortions.
authors: T
authors: T
authors: Ozçakir
authors: M A
authors: MA
authors: Thran
authors: F
authors: F
authors: Simşek
authors: C
authors: C
authors: Atay
authors: S
authors: S
authors: Vatansever
authors: K
authors: K
authors: Ozbilgin
mesh_terms: D000028:Abortion, Induced; D000030:Abortion, Missed / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D000328:Adult; D003656:Decidua / Q000378:metabolism / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D009389:Neovascularization, Pathologic / Q000150:complications / Q000175:diagnosis / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010920:Placenta / Q000473:pathology / Q000502:physiology; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D052247:Nitric Oxide Synthase Type II; D040281:Vascular Endothelial Growth Factor Receptor-1