title: Angiotensin-converting enzyme I/D polymorphism and acute respiratory distress syndrome.
abstract: BACKGROUND
  Some studies have assessed the association between angiotensin-converting enzyme (ACE) I/D polymorphism and acute respiratory distress syndrome (ARDS) risk. However, the results have been inconclusive and contradictory. Therefore, we performed a meta-analysis to investigate the association between ACE I/D polymorphism and ARDS risk.
  
  
  METHODS
  All relevant studies were searched using PubMed and EMBASE. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models or fixed-effects models.
  
  
  RESULTS
  A total of 14 studies with 5218 subjects were included in this meta-analysis. We found that ACE I/D polymorphism significantly associated with an increased ARDS risk (OR=1.57; 95% CI 1.30-1.89; P<0.00001). In the subgroup analysis by race, Caucasians with ACE I/D polymorphism showed increased ARDS risk (OR=1.63; 95% CI 1.32-2.02; P<0.00001). However, Asians with this polymorphism did not show significantly increased ARDS risk (OR=1.31; 95% CI 0.90-1.90; P=0.95). In the subgroup analysis by age group, adults showed increased ARDS risk (OR=1.60; 95% CI 1.32-1.93; P<0.00001), while pediatric patients did not have increased ARDS risk (OR=1.15; 95% CI 0.57-2.30; P=0.70).
  
  
  CONCLUSIONS
  This meta-analysis suggested that ACE I/D polymorphism might contribute to the susceptibility for ARDS.
authors: Department of Emergency Medicine, The Central Hospital of Minhang District, Shanghai, China dengchengsheng@sina.com.
authors: Xingqi
authors: X
authors: Deng
authors: Department of Respiratory Medicine, Second People's Hospital of Weifang, Weifang, Shandong, China.
authors: Shaokun
authors: S
authors: Zhang
authors: Department of Emergency Medicine, The Central Hospital of Minhang District, Shanghai, China.
authors: Kun
authors: K
authors: Jin
authors: Department of Emergency Medicine, The Central Hospital of Minhang District, Shanghai, China.
authors: Lanyan
authors: L
authors: Li
authors: Department of Emergency Medicine, The Central Hospital of Minhang District, Shanghai, China.
authors: Wei
authors: W
authors: Gu
authors: Department of Emergency Medicine, The Central Hospital of Minhang District, Shanghai, China.
authors: Mei
authors: M
authors: Liu
authors: Department of Emergency Medicine, The Central Hospital of Minhang District, Shanghai, China.
authors: Ling
authors: L
authors: Zhou
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012128:Respiratory Distress Syndrome / Q000201:enzymology* / Q000235:genetics*; D012307:Risk Factors
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: Angiotensin-converting enzyme; acute respiratory distress syndrome; association study; genetics; polymorphism