title: Pseudotumoral rebound of multiple sclerosis in a pregnant patient after stopping natalizumab.
abstract: Natalizumab is a highly efficacious treatment for active relapsing-remitting multiple sclerosis, dramatically reducing both clinical and radiological signs of inflammation in most patients. The disease course after stopping treatment and especially the emergence of rebound activity are still a matter of debate. We present a case of dramatic reactivation of clinical disease activity with newly emerging pseudotumoral lesions in a patient who stopped treatment due to pregnancy. Both the clinical and radiological presentation suggest a rebound and necessitate close monitoring of patients stopping their treatment during pregnancy, even after a long period of stable disease.
authors: University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: alexanderverhaeghe_1@hotmail.com.
authors: Alexander
authors: A
authors: Verhaeghe
authors: Department of Neurology, AZ Sint-Jan Brugge-Oostende AV, Ruddershove 10, 8000 Brugge, Belgium. Electronic address: olivier.deryck@azsintjan.be.
authors: Olivier Maurice
authors: OM
authors: Deryck
authors: Department of Neurology, AZ Sint-Jan Brugge-Oostende AV, Ruddershove 10, 8000 Brugge, Belgium. Electronic address: ludo.vanopdenbosch@azsintjan.be.
authors: Ludo J
authors: LJ
authors: Vanopdenbosch
keywords: Multiple sclerosis; Natalizumab; Pregnancy; Pseudotumoral; Rebound