title: Subclinical Hypothyroidism and the Risk of Stroke Events and Fatal Stroke: An Individual Participant Data Analysis.
abstract: OBJECTIVE
  The objective was to determine the risk of stroke associated with subclinical hypothyroidism.
  
  
  METHODS
  Published prospective cohort studies were identified through a systematic search through November 2013 without restrictions in several databases. Unpublished studies were identified through the Thyroid Studies Collaboration. We collected individual participant data on thyroid function and stroke outcome. Euthyroidism was defined as TSH levels of 0.45-4.49 mIU/L, and subclinical hypothyroidism was defined as TSH levels of 4.5-19.9 mIU/L with normal T4 levels.
  
  
  METHODS
  We collected individual participant data on 47 573 adults (3451 subclinical hypothyroidism) from 17 cohorts and followed up from 1972-2014 (489 192 person-years). Age- and sex-adjusted pooled hazard ratios (HRs) for participants with subclinical hypothyroidism compared to euthyroidism were 1.05 (95% confidence interval [CI], 0.91-1.21) for stroke events (combined fatal and nonfatal stroke) and 1.07 (95% CI, 0.80-1.42) for fatal stroke. Stratified by age, the HR for stroke events was 3.32 (95% CI, 1.25-8.80) for individuals aged 18-49 years. There was an increased risk of fatal stroke in the age groups 18-49 and 50-64 years, with a HR of 4.22 (95% CI, 1.08-16.55) and 2.86 (95% CI, 1.31-6.26), respectively (p trend 0.04). We found no increased risk for those 65-79 years old (HR, 1.00; 95% CI, 0.86-1.18) or ≥ 80 years old (HR, 1.31; 95% CI, 0.79-2.18). There was a pattern of increased risk of fatal stroke with higher TSH concentrations.
  
  
  CONCLUSIONS
  Although no overall effect of subclinical hypothyroidism on stroke could be demonstrated, an increased risk in subjects younger than 65 years and those with higher TSH concentrations was observed.
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Layal
authors: L
authors: Chaker
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Christine
authors: C
authors: Baumgartner
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Wendy P J
authors: WP
authors: den Elzen
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: M Arfan
authors: MA
authors: Ikram
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Manuel R
authors: MR
authors: Blum
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Tinh-Hai
authors: TH
authors: Collet
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Stephan J L
authors: SJ
authors: Bakker
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Abbas
authors: A
authors: Dehghan
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Christiane
authors: C
authors: Drechsler
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Robert N
authors: RN
authors: Luben
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Albert
authors: A
authors: Hofman
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Marileen L P
authors: ML
authors: Portegies
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Marco
authors: M
authors: Medici
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Giorgio
authors: G
authors: Iervasi
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: David J
authors: DJ
authors: Stott
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Ian
authors: I
authors: Ford
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Alexandra
authors: A
authors: Bremner
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Christoph
authors: C
authors: Wanner
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Luigi
authors: L
authors: Ferrucci
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Anne B
authors: AB
authors: Newman
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Robin P
authors: RP
authors: Dullaart
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: José A
authors: JA
authors: Sgarbi
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Graziano
authors: G
authors: Ceresini
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Rui M B
authors: RM
authors: Maciel
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Rudi G
authors: RG
authors: Westendorp
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: J Wouter
authors: JW
authors: Jukema
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Misa
authors: M
authors: Imaizumi
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Jayne A
authors: JA
authors: Franklyn
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Douglas C
authors: DC
authors: Bauer
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: John P
authors: JP
authors: Walsh
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Salman
authors: S
authors: Razvi
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Kay-Tee
authors: KT
authors: Khaw
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Anne R
authors: AR
authors: Cappola
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Henry
authors: H
authors: Völzke
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Oscar H
authors: OH
authors: Franco
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Jacobijn
authors: J
authors: Gussekloo
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Nicolas
authors: N
authors: Rodondi
authors: Department of Internal Medicine (L.C., M.M., R.P.P.), and Rotterdam Thyroid Center, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Epidemiology (L.C., M.A.I., A.D., A.H., M.L.P.P., O.H.F.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of General Internal Medicine (C.B., M.R.B., N.R.), Inselspital, Bern University Hospital, 3010 Bern, Switzerland; Departments of Epidemiology, Public Health, and Primary Care (W.P.J.d.E., J.G.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Department of Radiology (M.A.I.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Department of Neurology (M.A.I., M.L.P.P.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands; Service of Endocrinology, Diabetes, and Metabolism (T.-H.C.), University Hospital of Lausanne, 1011 Lausanne, Switzerland; Department of Internal Medicine (S.J.L.B., R.P.D.), University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands; Department of Medicine (C.D., C.W.), Division of Nephrology, University Hospital of Würzburg, Germany Comprehensive Heart Failure Centre, D-97080 Würzburg, Germany; Department of Public Health and Primary Care (R.N.L., K.-T.K.), University of Cambridge, Cambridge CB2 1TN, United Kingdom; National Council Research Institute of Clinical Physiology (G.I.), Pisa 56124, Italy; Institute of Cardiovascular and Medical Sciences, Faculty of Medicine (D.J.S.), and Robertson Centre for Biostatistics (I.F.), University of Glasgow, Glasgow G12 8QQ, United Kingdom; School of Population Health (A.B.), University of Western Australia, Crawley, Perth 6009, Western Australia, Australia; National Institute on Aging (L.F.), Baltimore, Maryland 20892; Department of Epidemiology (A.B.N.), University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Endocrinology (J.A.S.), Faculdade de Medicina de Marília, Marília, Sao Paulo 17519, Brazil; Di
authors: Robin P
authors: RP
authors: Peeters
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality; D013972:Thyrotropin / Q000097:blood
chemical_list: D013972:Thyrotropin