title: Prognostic significance of interim PET/CT based on visual, SUV-based, and MTV-based assessment in the treatment of peripheral T-cell lymphoma.
abstract: BACKGROUND
  The role of interim PET/CT in peripheral T-cell lymphoma (PTCL) is less identified compared to other subtype of lymphoma. This study prospectively investigated the prognostic accuracy of sequential interim PET/CT using visual and quantitative assessment to determine whether it provided prognostic information for the treatment of PTCL.
  
  
  METHODS
  Sixty-three patients with newly diagnosed PTCL were enrolled, and 59 patients underwent interim PET/CT after three or four courses of induction treatment. The response of interim PET/CT was assessed by three parameters: the Deauville five-point scale (5-PS), ΔSUVmax, and ΔMTV2.5.
  
  
  RESULTS
  Over a median follow up of 40.3 months, each assessment of interim PET/CT using the 5-PS, ΔSUVmax, and ΔMTV2.5 had predictive value for progression-free survival. To increase the predictive accuracy of interim PET/CT, we divided patients into three groups according to the sum of scores for three adverse responses based on the visual, SUV-based and MTV-based assessment: favorable, intermediate, and poor responder. The clinical outcome of patients in the favorable group was significantly superior to patients in the poor or intermediate group.
  
  
  CONCLUSIONS
  Visual, quantitative SUV-based, and MTV-based assessment in interim PET/CT are valuable for early treatment response assessment in patients with PTCL, and the combined approach using the three parameters was more efficient in discriminating between patients with different survival outcomes compared with single-parameter assessment.
  
  
  BACKGROUND
  NCT01470066 .
authors: Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, Jeollanamdo, 519-763, Republic of Korea. shglory@hanmail.net.
authors: Sung-Hoon
authors: SH
authors: Jung
authors: Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, Jeollanamdo, 519-763, Republic of Korea. ahnjaesook@hanmail.net.
authors: Jae-Sook
authors: JS
authors: Ahn
authors: Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, Jeollanamdo, 519-763, Republic of Korea. kimcnuh@naver.com.
authors: Yeo-Kyeoung
authors: YK
authors: Kim
authors: Department of preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea. ujingogo@paran.com.
authors: Sun-Seog
authors: SS
authors: Kweon
authors: Institute for Molecular Photonic Imaging Research, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Republic of Korea. jjmin@jnu.ac.kr.
authors: Jung-Joon
authors: JJ
authors: Min
authors: Institute for Molecular Photonic Imaging Research, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, Republic of Korea. hsbom@jnu.ac.kr.
authors: Hee-Seung
authors: HS
authors: Bom
authors: Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, Jeollanamdo, 519-763, Republic of Korea. hjoonk@chonnam.ac.kr.
authors: Hyeoung-Joon
authors: HJ
authors: Kim
authors: Department of Hematology/oncology, Kyungpook National University Hospital, Daegu, Republic of Korea. yschae@knu.ac.kr.
authors: Yee Soo
authors: YS
authors: Chae
authors: Department of Hematology/oncology, Kyungpook National University Hospital, Daegu, Republic of Korea. jhmoon@knu.ac.kr.
authors: Joon Ho
authors: JH
authors: Moon
authors: Department of Hematology/oncology, Kyungpook National University Hospital, Daegu, Republic of Korea. sksohn@knu.ac.kr.
authors: Sang Kyun
authors: SK
authors: Sohn
authors: Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea. swleenm@knu.ac.kr.
authors: Sang Woo
authors: SW
authors: Lee
authors: Nuclear Medicine, Korean Cancer Center Hospital, Seoul, Republic of Korea. dreamersball@paran.com.
authors: Byung Hyun
authors: BH
authors: Byun
authors: Hemato-oncology, Keimyung University Dongsan medical center, Daegu, Korea. dyr1160@dsmc.or.kr.
authors: Young Rok
authors: YR
authors: Do
authors: Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, Jeollanamdo, 519-763, Republic of Korea. drjejung@chonnam.ac.kr.
authors: Je-Jung
authors: JJ
authors: Lee
authors: Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, Jeollanamdo, 519-763, Republic of Korea. drydh1685@hotmail.com.
authors: Deok-Hwan
authors: DH
authors: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D053208:Kaplan-Meier Estimate; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods; D011379:Prognosis; D012372:ROC Curve; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18