title: [Impact of human cytomegalovirus viremia on relapse after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients].
abstract: OBJECTIVE
  To explore the relationship between cytomegalovirus (CMV) infection and risk factors for relapsing patients with acute myeloid leukemia (AML) (non- acute promyelocytic leukemia) after hematopoietic stem cell transplantation (HSCT).
  
  
  METHODS
  A total of 62 allo-HSCT patients from January 2005 to January 2014 were enrolled and analyzed retrospectively. And the clinical characteristics of donors and recipients and post-transplantation relapse were recorded.
  
  
  RESULTS
  Single factor analysis indicated that there were 5 risk factors correlated with disease relapse (P < 0.05). Leucocytosis (>100×10(9)/L), high-risk AML and cyclosporine A concentration under 200 µg/L were correlated with high relapsing rates while CMV reaction and chronic graft versus host disease had a low relapsing rate. Cox regression analysis revealed that high-risk AML (RR = 3.296, 95%CI:1.274-8.530, P = 0.014), CMV negativity (RR = 0.285, 95%CI:0.084-0.973, P = 0.045) and non-chronic GVHD (RR = 0.167, 95%CI:0.042-0.668, P = 0.011) were major risk factors of relapse.
  
  
  CONCLUSIONS
  Human CMV viremia after allo-HSCT has a decreased relapsing risk in patients with AML.
authors: Department of Hematology, Zhongshan Hospital of Sun Yat-sen University, Zhongshan 528403, China.
authors: Xiaomin
authors: X
authors: Niu
authors: Department of Hematology, Zhongshan Hospital of Sun Yat-sen University, Zhongshan 528403, China.
authors: Huiqing
authors: H
authors: He
authors: Department of Hematology, Zhongshan Hospital of Sun Yat-sen University, Zhongshan 528403, China.
authors: Ruiqing
authors: R
authors: Zhou
authors: Department of Hematology, Zhongshan Hospital of Sun Yat-sen University, Zhongshan 528403, China. Email:doctorxu@163.com.
authors: Xiaojun
authors: X
authors: Xu
mesh_terms: D002908:Chronic Disease; D003586:Cytomegalovirus Infections; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous; D014766:Viremia