title: Medicinal plants for the treatment of hypertrophic scars.
abstract: Hypertrophic scar is a complication of wound healing and has a high recurrence rate which can lead to significant abnormity in aesthetics and functions. To date, no ideal treatment method has been established. Meanwhile, the underlying mechanism of hypertrophic scarring has not been clearly defined. Although a large amount of scientific research has been reported on the use of medicinal plants as a natural source of treatment for hypertrophic scarring, it is currently scattered across a wide range of publications. Therefore, a systematic summary and knowledge for future prospects are necessary to facilitate further medicinal plant research for their potential use as antihypertrophic scar agents. A bibliographic investigation was accomplished by focusing on medicinal plants which have been scientifically tested in vitro and/or in vivo and proved as potential agents for the treatment of hypertrophic scars. Although the chemical components and mechanisms of action of medicinal plants with antihypertrophic scarring potential have been investigated, many others remain unknown. More investigations and clinical trials are necessary to make use of these medical plants reasonably and phytotherapy is a promising therapeutic approach against hypertrophic scars.
authors: College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China ; Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors: Qi
authors: Q
authors: Ye
authors: Central Laboratory, Shanghai Seventh People's Hospital, Shanghai 200137, China.
authors: Su-Juan
authors: SJ
authors: Wang
authors: Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai 200433, China ; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau.
authors: Jian-Yu
authors: JY
authors: Chen
authors: School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, Liverpool L3 3AF, UK.
authors: Khalid
authors: 0000-0002-4895-3594
authors: K
authors: Rahman
authors: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
authors: Hai-Liang
authors: HL
authors: Xin
authors: Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai 200433, China ; Central Laboratory, Shanghai Seventh People's Hospital, Shanghai 200137, China.
authors: Hong
authors: H
authors: Zhang