title: Coproduction of KPC-2 and IMP-10 in Carbapenem-Resistant Serratia marcescens Isolates from an Outbreak in a Brazilian Teaching Hospital.
abstract: We describe an outbreak caused by KPC-2- and IMP-10-producing Serratia marcescens isolates in a Brazilian teaching hospital. Tigecycline was the only active antimicrobial agent tested. The blaIMP-10 gene was located in a new class 1 integron, named In990, carried by a nonconjugative plasmid, in contrast to blaKPC-2.
authors: Laboratório de Pesquisa em Ciências da Saúde, Universidade Federal da Grande Dourados (UFGD), Dourados, Mato Grasso do Sul, Brazil.
authors: Kesia Esther
authors: KE
authors: Silva
authors: Laboratório ALERTA, Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors: Rodrigo
authors: R
authors: Cayô
authors: Laboratório ALERTA, Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors: Cecilia Godoy
authors: CG
authors: Carvalhaes
authors: Hospital Universitário de Dourados, Universidade Federal da Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil.
authors: Flávia
authors: F
authors: Patussi Correia Sacchi
authors: Laboratório ALERTA, Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors: Fernanda
authors: F
authors: Rodrigues-Costa
authors: Laboratório ALERTA, Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors: Ana Carolina
authors: AC
authors: Ramos da Silva
authors: Laboratório de Pesquisa em Ciências da Saúde, Universidade Federal da Grande Dourados (UFGD), Dourados, Mato Grasso do Sul, Brazil Hospital Universitário de Dourados, Universidade Federal da Grande Dourados (UFGD), Dourados, Mato Grosso do Sul, Brazil Fundação Osvaldo Cruz, Campo Grande, Mato Grosso do Sul, Brazil.
authors: Julio
authors: J
authors: Croda
authors: Laboratório ALERTA, Disciplina de Infectologia, Departamento de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors: Ana Cristina
authors: AC
authors: Gales
authors: Laboratório de Pesquisa em Ciências da Saúde, Universidade Federal da Grande Dourados (UFGD), Dourados, Mato Grasso do Sul, Brazil simonesimionatto@ufgd.edu.br.
authors: Simone
authors: S
authors: Simionatto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001938:Brazil / Q000453:epidemiology; D015780:Carbapenems / Q000494:pharmacology*; D002675:Child, Preschool; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics; D004196:Disease Outbreaks; D005260:Female; D005798:Genes, Bacterial; D006784:Hospitals, Teaching; D006801:Humans; D007223:Infant; D032023:Integrons; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D008969:Molecular Sequence Data; D010957:Plasmids; D017422:Sequence Analysis, DNA; D016868:Serratia Infections / Q000453:epidemiology* / Q000382:microbiology*; D012706:Serratia marcescens / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D000078304:Tigecycline; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D004269:DNA, Bacterial; D000078304:Tigecycline; D001618:beta-Lactamases; D008911:Minocycline