title: More than a decade after live donor nephrectomy: a prospective cohort study.
abstract: Previously reported short-term results after live kidney donation show no negative consequences for the donor. The incidence of new-onset morbidity takes years to emerge, making it highly likely that this will be missed during short-term follow-up. Therefore, evidence on long-term outcome is essential. A 10-year follow-up on renal function, hypertension, quality of life (QOL), fatigue, and survival was performed of a prospective cohort of 100 donors. After a median follow-up time of 10 years, clinical data were available for 97 donors and QOL data for 74 donors. Nine donors died during follow-up of unrelated causes to donation, and one donor was lost to follow-up. There was a significant decrease in kidney function of 12.9 ml/min (P < 0.001) at follow-up. QOL showed significant clinically relevant decreases of 10-year follow-up scores in SF-36 dimensions of physical function (P < 0.001), bodily pain (P = 0.001), and general health (P < 0.001). MFI-20 scores were significantly higher for general fatigue (P < 0.001), physical fatigue (P < 0.001), reduced activity (P = 0.019), and reduced motivation (P = 0.030). New-onset hypertension was present in 25.6% of the donors. Donor outcomes are excellent 10 years post-donation. Kidney function appears stable, and hypertension does not seem to occur more frequently compared to the general population.
authors: Department of Surgery, Division of HPB and Transplant Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
authors: Shiromani
authors: S
authors: Janki
authors: Department of Surgery, Division of HPB and Transplant Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
authors: Karel W J
authors: KW
authors: Klop
authors: Department of Internal Medicine, Division of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors: Ine M M
authors: IM
authors: Dooper
authors: Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
authors: Willem
authors: W
authors: Weimar
authors: Department of Surgery, Division of HPB and Transplant Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
authors: Jan N M
authors: JN
authors: Ijzermans
authors: Department of Surgery, Division of HPB and Transplant Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
authors: Niels F M
authors: NF
authors: Kok
mesh_terms: D000368:Aged; D015992:Body Mass Index; D005221:Fatigue / Q000150:complications* / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000628:therapy; D007677:Kidney Function Tests; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods*; D009426:Netherlands; D010146:Pain; D011446:Prospective Studies; D011788:Quality of Life; D012042:Registries; D051437:Renal Insufficiency / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome
keywords: 10-year follow-up; donor nephrectomy; live kidney donor; new-onset hypertension; quality of life; survival