title: [Catalase gene rs1001179 polymorphism and oxidative stress in patients with chronic hepatitis C and ulcerative colitis].
abstract: OBJECTIVE
  To study the rs1001179 polymorphism of the catalase (CAT) gene and to estimate the serum levels of the enzymes catalase and glutathione peroxidase (GP) in patients with chronic hepatitis C (CHC) and in those with ulcerative colitis (UC) in the Perm Territory.
  
  
  METHODS
  Ninety patients with reactivation-phase CHC and 50 patients with exacerbation-phase UC were examined. The serum levels of catalase and GP were determined and the polymorphic variants of the marker of CAT gene rs1001179 in the DNA isolated from whole blood were found in all the patients.
  
  
  RESULTS
  In the CHC and UC groups, the levels of catalase and GP were found to be lower than that in apparently healthy individuals. Furthermore, both groups showed a direct correlation between the activities of the enzymes. In the patients with CHC and in those with UC, the spread of genotypes and alleles generally failed to virtually differ from that in the control group. The G/G genotype was prevalent in all the groups. In the patients with CHC, the minor A allele demonstrated a significant inverse correlation with the enzyme catalase (r = -0.16; p = 0.02) and GP (r = -0.13; p = 0.047).
  
  
  CONCLUSIONS
  The lower serum levels of catalase and GP are indicative of oxidative stress in the patients with CHC or UC. In the patients with CHC, the significant correlation of the pathological rs1701179 A allele marker with the processes of synthesis of antioxidant enzymes may suggest that CAT gene polymorphism in the A/A homozygotes might affect the regulation mechanism involved in the antioxidant system in the liver.
authors: Acad. E.A. Wagner Perm State Medical Academy, Ministry of Health of Russia, Perm, Russia, Federal Research Center for Medical Prevention Technologies of Human Health Risk Management, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Perm, Russia.
authors: I A
authors: IA
authors: Bulatova
authors: Acad. E.A. Wagner Perm State Medical Academy, Ministry of Health of Russia, Perm, Russia, Federal Research Center for Medical Prevention Technologies of Human Health Risk Management, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Perm, Russia.
authors: Yu I
authors: YI
authors: Tretyakova
authors: Acad. E.A. Wagner Perm State Medical Academy, Ministry of Health of Russia, Perm, Russia, Federal Research Center for Medical Prevention Technologies of Human Health Risk Management, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Perm, Russia.
authors: V V
authors: VV
authors: Shchekotov
authors: Acad. E.A. Wagner Perm State Medical Academy, Ministry of Health of Russia, Perm, Russia, Federal Research Center for Medical Prevention Technologies of Human Health Risk Management, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Perm, Russia.
authors: A P
authors: AP
authors: Shchekotova
authors: Acad. E.A. Wagner Perm State Medical Academy, Ministry of Health of Russia, Perm, Russia, Federal Research Center for Medical Prevention Technologies of Human Health Risk Management, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Perm, Russia.
authors: P V
authors: PV
authors: Ulitina
authors: Acad. E.A. Wagner Perm State Medical Academy, Ministry of Health of Russia, Perm, Russia, Federal Research Center for Medical Prevention Technologies of Human Health Risk Management, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Perm, Russia.
authors: A V
authors: AV
authors: Krivtsov
authors: Acad. E.A. Wagner Perm State Medical Academy, Ministry of Health of Russia, Perm, Russia, Federal Research Center for Medical Prevention Technologies of Human Health Risk Management, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Perm, Russia.
authors: O Yu
authors: OY
authors: Nenasheva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002374:Catalase / Q000097:blood / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D019698:Hepatitis C, Chronic / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000235:genetics* / Q000502:physiology; D011110:Polymorphism, Genetic; D012800:Siberia; D055815:Young Adult
chemical_list: D002374:Catalase; D005979:Glutathione Peroxidase