title: Acute Interstitial Nephritis and Membranous Nephropathy in the Context of IgG4-Related Disease.
abstract: We present the case of a patient with IgG4-related disease, which manifested in an asynchronous manner as vitiligo, cholecystitis, sialadenitis, lymphadenopathy, facial palsy and kidney dysfunction. The patient underwent a renal biopsy, and a presumptive diagnosis of lupus nephritis was made due to compatible clinical and immunological findings. The biopsy revealed IgG4-related kidney disease with severe interstitial nephritis and membranous nephropathy. Corticosteroids treatment restored all disease manifestations. We bring this case to the attention of the nephrologists because of the protean, asynchronous, multisystemic nature of the disease that necessitates a multidisciplinary approach, a low threshold for kidney biopsy and a high index of suspicion for making the correct diagnosis and treatment.
authors: Nephrology Department, University Hospital of Heraklion, Heraklion, Greece.
authors: Kostas
authors: K
authors: Stylianou
authors: Nephrology Department, University Hospital of Heraklion, Heraklion, Greece.
authors: Eleftheria
authors: E
authors: Maragkaki
authors: Nephrology Department, University Hospital of Heraklion, Heraklion, Greece.
authors: Michael
authors: M
authors: Tzanakakis
authors: Nephrology Department, University Hospital of Heraklion, Heraklion, Greece.
authors: Stavros
authors: S
authors: Stratakis
authors: Pathology Department, National and Kapodistrian University of Athens, Athens, Greece.
authors: Hariklia
authors: H
authors: Gakiopoulou
authors: Nephrology Department, University Hospital of Heraklion, Heraklion, Greece.
authors: Eugene
authors: E
authors: Daphnis
keywords: IgG4-related disease; Interstitial nephritis; Membranous nephropathy