title: Targeting the Gremlin-VEGFR2 axis - a promising strategy for multiple diseases?
abstract: Published recently in the Journal of Pathology, Lavoz et al. show that Gremlin promotes renal inflammation directly via VEGFR2. As Gremlin has been implicated in many other diseases, such as heart, lung and liver fibrosis, osteogenesis, angiogenesis and cancer, the new findings provide a rationale for novel concepts to investigate and potentially treat several pathologies.
authors: Department of Haematology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Centre Hamburg, University Medical Centre Hamburg-Eppendorf, Germany.
authors: Robert
authors: R
authors: Erdmann
authors: Institute of Pathology, University Medical Centre Hamburg-Eppendorf, Germany.
authors: Cansu
authors: C
authors: Ozden
authors: Department of Haematology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Centre Hamburg, University Medical Centre Hamburg-Eppendorf, Germany.
authors: Jens
authors: J
authors: Weidmann
authors: Department of Haematology, Hubertus Wald Tumorzentrum, University Comprehensive Cancer Centre Hamburg, University Medical Centre Hamburg-Eppendorf, Germany.
authors: Alexander
authors: A
authors: Schultze
mesh_terms: D000818:Animals; D016207:Cytokines; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009393:Nephritis / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D036341:Intercellular Signaling Peptides and Proteins; D040301:Vascular Endothelial Growth Factor Receptor-2; C113178:Grem1 protein, mouse; C486399:GREM1 protein, human; C000588866:KDR protein, human; C000592875:Kdr protein, mouse
keywords: Gremlin; VEGFR2; cancer; fibrosis; renal inflammation