title: A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction.
abstract: In this report, we designed a histone deacetylase-targeted phosphorescent Re(I) complex ReLMito. Colocalization studies suggested that ReLMito could specially localize to mitochondria. We also demonstrated that ReLMito could induce paraptosis in cancer cells. These features endowed the complex with potential to induce and monitor mitochondrial morphological changes during the paraptosis simultaneously.
authors.affiliation: MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P. R. China. cesmzw@mail.sysu.edu.cn tancaip@mail.sysu.edu.cn.
authors.forename: Rui-Rong
authors.initials: RR
authors.lastname: Ye
authors.forename: Cai-Ping
authors.initials: CP
authors.lastname: Tan
authors.forename: Yan-Nan
authors.initials: YN
authors.lastname: Lin
authors.forename: Liang-Nian
authors.initials: LN
authors.lastname: Ji
authors.forename: Zong-Wan
authors.initials: ZW
authors.lastname: Mao
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D056572:Histone Deacetylase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D012211:Rhenium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000577:Amides; D056831:Coordination Complexes; D056572:Histone Deacetylase Inhibitors; D006657:Histones; D011725:Pyridines; D012211:Rhenium; D006655:Histone Deacetylases