title: Is Seprafilm valuable in infant cardiac redo procedures?
abstract: BACKGROUND
  Morbidity and mortality are higher for cardiac reoperations than first operation due to the presence of post-operative adhesions. We retrospectively evaluated the efficacy of the bioresorbable membrane Seprafilm to prevent pericardial adhesions after cardiac surgery in a paediatric congenital heart disease population.
  
  
  METHODS
  Seventy-one children undergoing reoperations with sternotomy redo and cardiopulmonary bypass for congenital malformations were included. Twenty-nine of these patients were reoperated after previous application of Seprafilm (treatment group). The duration of dissection, aortic cross clamping and total surgery were recorded. A tenacity score was established for each intervention from the surgeon's description in the operating report.
  
  
  RESULTS
  In multivariate analysis, the duration of dissection and the tenacity score were lower in the treatment than control group (p < 0.01), independent of age and interval since preceding surgery.
  
  
  CONCLUSIONS
  Our results suggest that Seprafilm is effective in reducing the post-operative adhesions associated with infant cardiac surgery. We recommend the use of Seprafilm in paediatric cardiac surgery when staged surgical interventions are necessary.
authors.affiliation: Children Hospital Gatien de Clocheville, Tours, France. bruno.lefort@univ-tours.fr.|University François Rabelais, Tours, France. bruno.lefort@univ-tours.fr.
authors.forename: Bruno
authors.initials: B
authors.lastname: Lefort
authors.affiliation: Children Hospital Gatien de Clocheville, Tours, France. jeanmarcelarid@hotmail.com.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: El Arid
authors.affiliation: Children Hospital Gatien de Clocheville, Tours, France. anne_lorrainebouquiaux@hotmail.com.
authors.forename: Anne-Lorraine
authors.initials: AL
authors.lastname: Bouquiaux
authors.affiliation: Children Hospital Gatien de Clocheville, Tours, France. n.soule@chu-tours.fr.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Soulé
authors.affiliation: Children Hospital Gatien de Clocheville, Tours, France. j.chantreuil@chu-tours.fr.
authors.forename: Julie
authors.initials: J
authors.lastname: Chantreuil
authors.affiliation: Children Hospital Gatien de Clocheville, Tours, France. elsa.tavernier@univ-tours.f.|INSERM, CIC 202, Tours, France. elsa.tavernier@univ-tours.f.
authors.forename: Elsa
authors.initials: E
authors.lastname: Tavernier
authors.affiliation: Children Hospital Gatien de Clocheville, Tours, France. chantepie@med.univ-tours.fr.|University François Rabelais, Tours, France. chantepie@med.univ-tours.fr.
authors.forename: Alain
authors.initials: A
authors.lastname: Chantepie
authors.affiliation: Children Hospital Gatien de Clocheville, Tours, France. p.neville@chu-tours.fr.
authors.forename: Paul
authors.initials: P
authors.lastname: Neville
mesh_terms: D002315:Cardiopulmonary Bypass; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D006820:Hyaluronic Acid; D007223:Infant; D008297:Male; D015999:Multivariate Analysis; D010496:Pericardium / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*; D012086:Reoperation; D012189:Retrospective Studies; D056346:Sternotomy; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*
chemical_list: C118198:Seprafilm; D006820:Hyaluronic Acid