title: Changing the concepts of immune-mediated glomerular diseases through proteomics.
abstract: Standard classification of glomerular diseases is based on histopathologic abnormalities. The recent application of proteomic technologies has resulted in paradigm changes in the understanding and classification of idiopathic membranous nephropathy and membranoproliferative glomerulonephritis. Those examples provide evidence that proteomics will lead to advances in understanding of the molecular basis of other glomerular diseases, such as lupus nephritis. Proof of principle experiments show that proteomics can be applied to patient renal biopsy specimens. This viewpoint summarizes the advances in immune-mediated glomerular diseases that have relied on proteomics, and potential future applications are discussed.
authors.affiliation: Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.|Robley Rex VA Medical Center, Louisville, KY, USA.
authors.forename: Dawn J
authors.initials: DJ
authors.lastname: Caster
authors.affiliation: Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: Liliane
authors.initials: L
authors.lastname: Hobeika
authors.affiliation: Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.|Robley Rex VA Medical Center, Louisville, KY, USA.
authors.forename: Jon B
authors.initials: JB
authors.lastname: Klein
authors.affiliation: Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Powell
authors.affiliation: Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.|Robley Rex VA Medical Center, Louisville, KY, USA.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: McLeish
mesh_terms: D000818:Animals; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology* / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000276:immunology* / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*
keywords: Antigen identification; Autoimmunity; Glomerulonephritis; Immune complex