title: Iodine-Mediated C-H Functionalization of sp, sp(2), and sp(3) Carbon: A Unified Multisubstrate Domino Approach for Isatin Synthesis.
abstract: Molecular iodine-promoted efficient construction of isatins from 2'-aminophenylacetylenes, 2'-aminostyrenes, and 2'-amino-β-ketoesters is developed via oxidative amidation of sp, sp(2), and sp(3) C-H bonds. The reaction involves consecutive iodination, Kornblum oxidation, and intramolecular amidation in a single reactor. The present method meets all of the atom and redox economy principles.
authors.affiliation: †School of Chemistry, Bharathidasan University, Tiruchirappalli 620024, India.
authors.forename: Gandhesiri
authors.initials: G
authors.lastname: Satish
authors.affiliation: †School of Chemistry, Bharathidasan University, Tiruchirappalli 620024, India.
authors.forename: Ashok
authors.initials: A
authors.lastname: Polu
authors.affiliation: †School of Chemistry, Bharathidasan University, Tiruchirappalli 620024, India.|‡Syngene International Limited, Bangalore 560 099, India.
authors.forename: Thangeswaran
authors.initials: T
authors.lastname: Ramar
authors.affiliation: †School of Chemistry, Bharathidasan University, Tiruchirappalli 620024, India.
authors.forename: Andivelu
authors.initials: A
authors.lastname: Ilangovan
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007455:Iodine / Q000737:chemistry*; D007510:Isatin / Q000138:chemical synthesis* / Q000737:chemistry; D007651:Keto Acids / Q000737:chemistry; D015394:Molecular Structure; D013343:Styrenes / Q000737:chemistry*
chemical_list: D000588:Amines; D007651:Keto Acids; D013343:Styrenes; C044736:phenylacetylene; D002244:Carbon; D007510:Isatin; D007455:Iodine; D000114:Acetylene