title: [Effect of microneedle combined with Lauromacrogol on skin capillary network: experimental study].
abstract: OBJECTIVE
  To explore the effect of microneedle combined with Lauromacrogol on skin capillary network.
  
  
  METHODS
  24 male Leghone (1.5-2.0 kg in weight) were randomly divided into three groups as group A (microneedle combined with Lauromacrogol), B (microneedle combined with physiological saline) , and C(control). The cockscombs were treated. The specimens were taken on the 7th, 14th, 21th , and 28th day postoperatively. HE staining, immunohistochemical staining and special staining were performed for study of the number of capillary and collagen I/III , as well as elastic fibers.
  
  
  RESULTS
  The color of cockscombs in group A became lightening after treatment. The number of capillary decreased as showing by HE staining. The collagen I and III in group B was significantly different from that in group A and C (P < 0.05). Special staining showed proliferation of elastic fibers in group B.
  
  
  CONCLUSIONS
  It indicates that microneedle combined with Lauromacrogol could effectively reduce the capillary in cockscomb without any tissue fibrosis. Microneedle can stimulate the proliferation of elastic fiber, so as to improve the skin ageing process.
authors.forename: Sida
authors.initials: S
authors.lastname: Xu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.forename: Youfen
authors.initials: Y
authors.lastname: Fan
authors.forename: Shihai
authors.initials: S
authors.lastname: Chen
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Liu
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yin
authors.forename: Mingde
authors.initials: M
authors.lastname: Liao
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000818:Animals; D002196:Capillaries / Q000033:anatomy & histology*; D002645:Chickens; D003129:Comb and Wattles / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D009339:Needles; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011677:Punctures / Q000295:instrumentation / Q000379:methods*; D011897:Random Allocation; D015595:Skin Aging
chemical_list: D011092:Polyethylene Glycols