title: Gender differences in cancer patients with acute venous thromboembolism.
abstract: BACKGROUND
  The outcome of cancer patients with acute venous thromboembolism (VTE) may differ according to gender.
  
  
  METHODS
  We used the RIETE database to compare the rate of VTE (pulmonary embolism [PE] or deep vein thrombosis [DVT]) recurrences), major bleeding and mortality during the course of anticoagulation, according to gender.
  
  
  RESULTS
  As of August 2014, 11,055 patients with active cancer were enrolled in RIETE, of whom 5,104 (46%) were women. During the course of anticoagulation (mean: 142 days), 505 patients developed recurrent VTE, 429 bled and 2730 died. Compared with men, women had a significantly lower rate of fatal bleeding (risk ratio [RR]: 0.69; 95% CI: 0.47-0.99) and death (RR: 0.90; 95% CI: 0.83-0.97), and a non-significantly lower rate of PE recurrences (RR 0.83; 95% CI: 0.65-1.06) and major bleeding (RR: 0.89; 95% CI: 0.74-1.08).
  
  
  CONCLUSIONS
  During the course of anticoagulation, cancer women with VTE had a better outcome than men.
authors.affiliation: Department of Internal Medicine, Hospital General Universitario Santa Lucía, Murcia, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Martín-Martos
authors.affiliation: Department of Internal Medicine, Hospital General Universitario Santa Lucía, Murcia, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Trujillo-Santos
authors.affiliation: Department of Pneumonology, Complejo Hospitalario San Pedro, La Rioja, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Barrón
authors.affiliation: Department of Internal Medicine, Hospital Universitario Miguel Servet, Zaragoza, Spain.
authors.forename: Jerónimo
authors.initials: J
authors.lastname: Vela
authors.affiliation: Department of Internal Medicine, Parc Sanitari Sant Joan de Deu-Hospital General, Barcelona, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Javier Marchena
authors.affiliation: Department of Haematology, Western Galilee Hospital, Nahariya, Israel.
authors.forename: Andrei
authors.initials: A
authors.lastname: Braester
authors.affiliation: Internal Medicine and Vascular Diseases Unit, Hôpital Saint-Louis, Paris, France.
authors.forename: Adrian
authors.initials: A
authors.lastname: Hij
authors.affiliation: Department of Pneumonology, Hospital General Universitario de Alicante, Alicante, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Hernández-Blasco
authors.affiliation: Department of Cardiovascular Science, Vascular Medicine and Haemostasis, University of Leuven, Leuven, Beigium.
authors.forename: Peter
authors.initials: P
authors.lastname: Verhamme
authors.affiliation: Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. Electronic address: mmonreal.germanstrias@gencat.cat.
authors.forename: Monreal
authors.initials: M
authors.lastname: Manuel
mesh_terms: D000208:Acute Disease; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D015897:Comorbidity; D005260:Female; D006470:Hemorrhage / Q000401:mortality*; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000401:mortality*; D012307:Risk Factors; D012727:Sex Characteristics; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D015996:Survival Rate; D016896:Treatment Outcome; D054556:Venous Thromboembolism / Q000188:drug therapy* / Q000401:mortality*
chemical_list: D000925:Anticoagulants
keywords: Anticoagulant drugs; Cancer; Gender; Hemorrhage; Mortality; Recurrence; Venous thromboembolism