title: Association between serum bicarbonate and pH with depression, cognition and sleep quality in hemodialysis patients.
abstract: Metabolic acidosis is a common feature in chronic renal failure patients, worsening progressively as renal function declines. There are conflicting data in hemodialysis (HD) patients with regard to acidosis, alkalosis and mortality. In HD patients, cognitive impairment, depression, sleep disorders and impaired quality of life are very common. Besides, these conditions are related with increased morbidity and mortality. However, no previous study investigated the relationship between pH, venous bicarbonate and anion gap with depression, sleep problems and cognitive function in HD patients. In this study we investigated these relationships. In total, 65 HD patients were included. The demographic parameters and laboratory parameters including bicarbonate, pH and anion gap was measured for all patients. Depressive symptoms, sleep quality and cognitive function, were measured by Beck depression inventory, The Pittsburgh Sleep Quality Index and by Mini Mental State Examination, respectively. We found that, sleep quality but not cognitive function or depression was independently related with venous pH and bicarbonate. Anion gap has no independent relationship with sleep quality, cognitive function and depression. In conclusion, metabolic acidosis and bicarbonate levels were independently related with sleep quality in HD patients. However, there was no association between metabolic acidosis and bicarbonate levels with cognitive function and depression.
authors.affiliation: a Department of Nephrology , Konya Numune Hospital , Konya , Turkey and.
authors.forename: Baris
authors.initials: B
authors.lastname: Afsar
authors.affiliation: b Department of Nephrology , Selcuk University Faculty of Medicine , Konya , Turkey.
authors.forename: Rengin
authors.initials: R
authors.lastname: Elsurer
mesh_terms: D000138:Acidosis / Q000175:diagnosis / Q000453:epidemiology*; D017677:Age Distribution; D000704:Analysis of Variance; D001639:Bicarbonates / Q000097:blood; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000097:blood / Q000453:epidemiology / Q000628:therapy*; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D017286:Polysomnography / Q000379:methods; D006435:Renal Dialysis / Q000009:adverse effects / Q000523:psychology*; D012720:Severity of Illness Index; D017678:Sex Distribution; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000453:epidemiology*; D018709:Statistics, Nonparametric; D015996:Survival Rate
chemical_list: D001639:Bicarbonates
keywords: Acidosis; bicarbonate; cognitive; depression; dialysis; sleep