title: Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients.
abstract: In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan ; Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Naganawa
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Takayama
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan ; Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Adachi
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Mitsudo
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Iida
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Kamiya-Mizuno
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan.
authors.forename: Harumi
authors.initials: H
authors.lastname: Kawaki
authors.affiliation: Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Ichinose
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Motohashi
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Muramatsu
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Yokohama, Kanagawa 236-0004, Japan.
authors.forename: Iwai
authors.initials: I
authors.lastname: Tohnai
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan.
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Sumitomo
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Shikimori
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kondoh
keywords: Cytokine-producing capability; Oral squamous cell carcinoma; interferon-gamma (IFN-γ); peripheral blood; tumor immunology