title: Glioblastoma multiforme and papillary thyroid carcinoma - A rare combination of multiple primary malignancies.
abstract: We are describing a 19-year-old white woman who presented with two synchronous primary cancers, namely glioblastoma multiforme and papillary thyroid cancer. The patient was admitted with dizziness, headache, and vomiting. CT head revealed acute intraparenchymal hematoma in the right cingulate gyrus and the splenium of the corpus callosum. Carotid and cerebral angiogram were unremarkable. MRI of the brain demonstrated a non-enhancing and non-hemorrhagic component of the lesion along the lateral margin of the hemorrhage just medial to the atrium of the right lateral ventricle that was suspicious for a tumor or metastasis. Brain biopsy confirmed it as glioblastoma mutiforme. CT chest was done to rule out primary cancer that revealed a 11 mm hypodense lesion in the left lobe of the thyroid and ultrasound-guided fine-needle aspiration biopsy confirmed it as papillary thyroid carcinoma. We should evaluate for multiple primary malignancies in young patients who are found to have primary index cancer.
authors.affiliation: Department of Research, Health East Care System, Saint Paul, Minnesota, USA.
authors.forename: Swaroopa
authors.initials: S
authors.lastname: Pulivarthi
authors.affiliation: Department of Endocrinology, Health East Care System, Saint Paul, Minnesota, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Haglind
authors.affiliation: Department of Pathology, Health East Care System, Saint Paul, Minnesota, USA.
authors.forename: Carl T
authors.initials: CT
authors.lastname: McGary
authors.affiliation: Department of Internal Medicine, Health East Care System, Saint Paul, Minnesota, USA.
authors.forename: Murali Krishna
authors.initials: MK
authors.lastname: Gurram
keywords: Glioblastoma multiforme; multiple primary malignancies; papillary thyroid cancer