title: Acute kidney injury after cardiac arrest.
abstract: BACKGROUND
  The aim of this study was to evaluate the incidence and determinants of AKI in a large cohort of cardiac arrest patients.
  
  
  METHODS
  We reviewed all patients admitted, for at least 48 hours, to our Dept. of Intensive Care after CA between January 2008 and October 2012. AKI was defined as oligo-anuria (daily urine output <0.5 ml/kg/h) and/or an increase in serum creatinine (≥0.3 mg/dl from admission value within 48 hours or a 1.5 time from baseline level). Demographics, comorbidities, CA details, and ICU interventions were recorded. Neurological outcome was assessed at 3 months using the Cerebral Performance Category scale (CPC 1-2 = favorable outcome; 3-5 = poor outcome).
  
  
  RESULTS
  A total of 199 patients were included, 85 (43%) of whom developed AKI during the ICU stay. Independent predictors of AKI development were older age, chronic renal disease, higher dose of epinephrine, in-hospital CA, presence of shock during the ICU stay, a low creatinine clearance (CrCl) on admission and a high cumulative fluid balance at 48 hours. Patients with AKI had higher hospital mortality (55/85 vs. 57/114, p = 0.04), but AKI was not an independent predictor of poor 3-month neurological outcome.
  
  
  CONCLUSIONS
  AKI occurred in more than 40% of patients after CA. These patients had more severe hemodynamic impairment and needed more aggressive ICU therapy; however the development of AKI did not influence neurological recovery.
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. omartujjar@hotmail.com.
authors.forename: Omar
authors.initials: O
authors.lastname: Tujjar
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. giuliamineo@hotmail.it.
authors.forename: Giulia
authors.initials: G
authors.lastname: Mineo
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. anthosdel@yahoo.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Dell'Anna
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. bpoyatosrobles83@gmail.com.
authors.forename: Belen
authors.initials: B
authors.lastname: Poyatos-Robles
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. katia_doc@yahoo.it.
authors.forename: Katia
authors.initials: K
authors.lastname: Donadello
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. scolletta@unisit.it.
authors.forename: Sabino
authors.initials: S
authors.lastname: Scolletta
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. jlvincen@ulb.ac.be.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Vincent
authors.affiliation: Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. ftaccone@ulb.ac.be.
authors.forename: Fabio Silvio
authors.initials: FS
authors.lastname: Taccone
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D001002:Anuria / Q000175:diagnosis; D006323:Heart Arrest / Q000150:complications* / Q000453:epidemiology / Q000401:mortality / Q000628:therapy; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D009846:Oliguria / Q000175:diagnosis; D012189:Retrospective Studies