title: Molecular Basis of Resistance to Selected Antimicrobial Agents in the Emerging Zoonotic Pathogen Streptococcus suis.
abstract: Characterization of 227 Streptococcus suis strains isolated from pigs during 2010 to 2013 showed high levels of resistance to clindamycin (95.6%), tilmicosin (94.7%), tylosin (93.8%), oxytetracycline (89.4%), chlortetracycline (86.8%), tiamulin (72.7%), neomycin (70.0%), enrofloxacin (56.4%), penicillin (56.4%), ceftiofur (55.9%), and gentamicin (55.1%). Resistance to tetracyclines, macrolides, aminoglycosides, and fluoroquinolone was attributed to the tet gene, erm(B), erm(C), mph(C), and mef(A) and/or mef(E) genes, aph(3')-IIIa and aac(6')-Ie-aph(2″)-Ia genes, and single point mutations in the quinolone resistance-determining region of ParC and GyrA, respectively.
authors.affiliation: Bacterial Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, Republic of Korea.
authors.forename: Mamata
authors.initials: M
authors.lastname: Gurung
authors.affiliation: Bacterial Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, Republic of Korea.
authors.forename: Migma Dorji
authors.initials: MD
authors.lastname: Tamang
authors.affiliation: Bacterial Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, Republic of Korea.
authors.forename: Dong Chan
authors.initials: DC
authors.lastname: Moon
authors.affiliation: Bacterial Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, Republic of Korea.
authors.forename: Su-Ran
authors.initials: SR
authors.lastname: Kim
authors.affiliation: Bacterial Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, Republic of Korea.
authors.forename: Jin-Ha
authors.initials: JH
authors.lastname: Jeong
authors.affiliation: Bacterial Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, Republic of Korea.
authors.forename: Geum-Chan
authors.initials: GC
authors.lastname: Jang
authors.affiliation: Bacterial Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, Republic of Korea.
authors.forename: Suk-Chan
authors.initials: SC
authors.lastname: Jung
authors.affiliation: Department of Microbiology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
authors.forename: Yong-Ho
authors.initials: YH
authors.lastname: Park
authors.affiliation: Bacterial Disease Division, Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, Republic of Korea imsk0049@korea.kr.
authors.forename: Suk-Kyung
authors.initials: SK
authors.lastname: Lim
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial; D008826:Microbial Sensitivity Tests; D017422:Sequence Analysis, DNA; D013290:Streptococcal Infections / Q000662:veterinary; D017011:Streptococcus suis / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D013552:Swine
chemical_list: D000890:Anti-Infective Agents; D001426:Bacterial Proteins