title: Exendin-4 improves thermogenic capacity by regulating fat metabolism on brown adipose tissue in mice with diet-induced obesity.
abstract: OBJECTIVE
  This study aimed to investigate the benefits of exendin-4 treatment on brown adipose tissue (BAT) in C57BL/6J mice with high-fat diet (HFD)-induced obesity.
  
  
  METHODS
  We examined the effects of exendin-4 on body adiposity and the level of genes associated with adipogenesis, glucose/lipid uptake, lipolysis, and thermogenesis in mice with diet-induced obesity.
  
  
  RESULTS
  Exendin-4 treatment deceased body weight, serum-free fatty acid, and triglyceride levels in HFD-induced obese C57BL/6J mice. Exendin-4 treatment increased the expression of genes associated with adipogenesis, glucose/lipid uptake, lipolysis, and thermogenesis in BAT. Compared with HFD-fed mice, exendin-4 treatment also exhibited elevated energy expenditure and reduced respiratory quotient, but showed similar food intake and locomotor activity.
  
  
  CONCLUSIONS
  Exendin-4 treatment reduced high-fat-induced obesity by decreasing adiposity and increasing thermogenesis. This result suggests that GLP-1 agonist may be a new approach to combat obesity by shifting the energy balance from obesogenesis to thermogenesis.
authors.affiliation: Department of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Environmental Hygiene, College of Military Preventive Medicine, Third Military Medical University, Chongqing, China.
authors.forename: Ji-an
authors.initials: JA
authors.lastname: Chen
authors.affiliation: Department of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing.
authors.forename: Shao-hua
authors.initials: SH
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Affiliated ZhongDa Hospital of Southeast University, Nanjing zilinsun@yahoo.com.
authors.forename: Zi-lin
authors.initials: ZL
authors.lastname: Sun
mesh_terms: D050156:Adipogenesis / Q000187:drug effects / Q000235:genetics; D052242:Adiponectin / Q000097:blood; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects*; D004734:Energy Metabolism / Q000187:drug effects; D000077270:Exenatide; D005215:Fasting / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D005247:Feeding Behavior / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D005947:Glucose / Q000378:metabolism; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects* / Q000235:genetics; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009765:Obesity / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D010455:Peptides / Q000494:pharmacology*; D022722:Thermogenesis / Q000187:drug effects* / Q000235:genetics; D014280:Triglycerides / Q000097:blood; D014688:Venoms / Q000494:pharmacology*
chemical_list: D052242:Adiponectin; D005227:Fatty Acids; D020738:Leptin; D010455:Peptides; D014280:Triglycerides; D014688:Venoms; D000077270:Exenatide; D005947:Glucose
keywords: Glucagon-like Peptide-1 Receptor Agonist; Thermogenesis; obesity