title: Target Acquired: Progress and Promise of Targeted Therapeutics in the Treatment of Prostate Cancer.
abstract: Cancer is fundamentally a genomic disease caused by mutations or rearrangements in the DNA or epigenetic machinery of a patient. An emerging field in cancer treatment targets key aberrations arising from the mutational landscape of an individual patient's disease rather than employing a cancer-wide cytotoxic therapy approach. In prostate cancer in particular, where there is an observed variation in response to standard treatments between patients with disease of a similar pathological stage and grade, mutationdirected treatment may grow to be a viable tool for clinicians to tailor more effective treatments. This review will describe a number of mutations across multiple forms of cancer that have been successfully antagonised by targeted therapeutics including their identification, the development of targeted compounds to combat them and the development of resistance to these therapies. This review will continue to examine these same mutations in the treatment and management of prostate cancer; the prevalence of targetable mutations in prostate cancer, recent clinical trials of targeted-agents and the potential or limitations for their use.
authors.forename: Ryan
authors.initials: R
authors.lastname: Stuchbery
authors.forename: Natalie J
authors.initials: NJ
authors.lastname: Kurganovs
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: McCoy
authors.forename: Colleen C
authors.initials: CC
authors.lastname: Nelson
authors.forename: Vanessa M
authors.initials: VM
authors.lastname: Hayes
authors.forename: Niall M
authors.initials: NM
authors.lastname: Corcoran
authors.affiliation: Department of Surgery, The University of Melbourne, 5th Floor Clinical Sciences Building, Royal Melbourne Hospital, Grattan Street, Parkville, Victoria, Australia. chovens@unimelb.edu.au.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Hovens
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D018390:Gene Targeting / Q000379:methods / Q000639:trends*; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents