title: [Stable analogues of coenzyme-substrate complex of spermidine/spermine-N1-acetyltransferase reaction. synthesis, interaction with the enzyme].
abstract: Convenient two-step synthesis of conjugates of HS-CoA and D-pantetheine with aminooxy analogues of Spm, Spd and Put was suggested. The use of acetone linker provided target conjugates with quantitative yields. The activity of CoA-derived "bisubstrate" inhibitors being active at microM concentrations was at least 100 times better than that of corresponding derivatives of D-pantetheine.
authors.forename: T A
authors.initials: TA
authors.lastname: Keĭnanen
authors.forename: T
authors.initials: T
authors.lastname: Khivonen
authors.forename: Ĭ
authors.initials: Ĭ
authors.lastname: Vepsalajnen
authors.forename: L
authors.initials: L
authors.lastname: Alhonen
authors.forename: A R
authors.initials: AR
authors.lastname: Homutov
authors.forename: Iu
authors.initials: Iu
authors.lastname: Ianne
mesh_terms: D000105:Acetyl Coenzyme A / Q000737:chemistry; D000123:Acetyltransferases / Q000138:chemical synthesis* / Q000737:chemistry; D001419:Bacteria / Q000737:chemistry / Q000378:metabolism / Q000472:pathogenicity; D007700:Kinetics; D010204:Pantetheine / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry / Q000378:metabolism*; D013095:Spermidine / Q000138:chemical synthesis* / Q000737:chemistry; D013096:Spermine / Q000138:chemical synthesis* / Q000737:chemistry; D000099228:Diamine N-Acetyltransferase
chemical_list: D000105:Acetyl Coenzyme A; D000123:Acetyltransferases; D010204:Pantetheine; D011073:Polyamines; D013095:Spermidine; D013096:Spermine; D000099228:Diamine N-Acetyltransferase