title: Does vitamin D play a significant role in type 2 diabetes?
abstract: BACKGROUND
  Vitamin D deficiency reportedly is associated with type 2 diabetes (T2DM). We aim to examine whether 25-hydroxyvitamin D (25OHD) has clinically significant influence on hemoglobin glycation (HbA1c) and insulin resistance (HOMA-IR) in T2DM subjects.
  
  
  METHODS
  Present study was carried out in 912 subjects (429 T2DM cases and 483 non-diabetic controls) from Western India. The enrolled study subjects were investigated for biochemical parameters like FBS, PPBS, HbA1c, FI, HOMA-IR and 25OHD levels in blood.
  
  
  RESULTS
  Vitamin D deficiency was seen in 91.4% and 93.0% of T2DM cases and control subjects respectively. There was no association of serum 25OHD deficiency on HbA1c or HOMA-IR in T2DM cases (p = 0.057 & p = 0.257 respectively) and in control subjects (p = 0.675 & p = 0.647 respectively).
  
  
  CONCLUSIONS
  Our findings suggests that though vitamin D deficiency is prevalent in T2DM and non-diabetic subjects, its role in hemoglobin glycation and insulin resistance could not be established.
authors.affiliation: Department of Biochemistry and Molecular Genetics, FRIGE's Institute of Human Genetics, FRIGE House, Jodhpur Gam Road, Satellite, Ahmedabad, 380015, India. jshethad1@gmail.com.
authors.forename: Jayesh J
authors.initials: JJ
authors.lastname: Sheth
authors.affiliation: Department of Biochemistry and Molecular Genetics, FRIGE's Institute of Human Genetics, FRIGE House, Jodhpur Gam Road, Satellite, Ahmedabad, 380015, India. anknashah@yahoo.co.in.
authors.forename: Ankna
authors.initials: A
authors.lastname: Shah
authors.affiliation: Department of Biochemistry and Molecular Genetics, FRIGE's Institute of Human Genetics, FRIGE House, Jodhpur Gam Road, Satellite, Ahmedabad, 380015, India. fshethad1@googlemail.com.
authors.forename: Frenny J
authors.initials: FJ
authors.lastname: Sheth
authors.affiliation: Department of Biochemistry and Molecular Genetics, FRIGE's Institute of Human Genetics, FRIGE House, Jodhpur Gam Road, Satellite, Ahmedabad, 380015, India. drsuniltrivedi@hotmail.com.
authors.forename: Sunil
authors.initials: S
authors.lastname: Trivedi
authors.affiliation: Unit of Endocrine and Metabolic Disorders, Kasturba Health Society, Medical Research Centre, Mumbai, 400056, India. mamtalele@gmail.com.
authors.forename: Mamta
authors.initials: M
authors.lastname: Lele
authors.affiliation: Department of Diabetes and Endocrinology, Sterling Hospital, Ahmedabad, 380052, India. navneetnshah2000@gmail.com.
authors.forename: Navneet
authors.initials: N
authors.lastname: Shah
authors.affiliation: Gujarat Diabetic Association, Ahmedabad, 380007, India. pbthakor36@yahoo.co.uk.
authors.forename: Premal
authors.initials: P
authors.lastname: Thakor
authors.affiliation: Unit of Endocrine and Metabolic Disorders, Kasturba Health Society, Medical Research Centre, Mumbai, 400056, India. rama.vaidya@gmail.com.
authors.forename: Rama
authors.initials: R
authors.lastname: Vaidya
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications* / Q000453:epidemiology
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D