title: A comparison of pre and post-operative vedaprofen with ketoprofen for pain control in dogs.
abstract: BACKGROUND
  This prospective randomized blinded clinical study aimed to investigate the potential of vedaprofen for preventive analgesia, comparing its analgesic effects with ketoprofen administered post-operatively in dogs undergoing maxillectomy or mandibulectomy.
  
  
  RESULTS
  Pain control was effective and rescue analgesia was not necessary in any group. Pain scores were not significantly different between groups. The respiratory rate and rectal temperature were decreased in all groups at extubation until 6 hours post-extubation compared to baseline. Cortisol and epinephrine levels were increased only at 0.5 hours after extubation in all groups compared to baseline.
  
  
  CONCLUSIONS
  Vedaprofen did not present any preventive analgesic effect. Pre- and postoperative vedaprofen were as effective as ketoprofen for postoperative pain control.
authors.affiliation: Laboratório de Investigação Médica 8, Anestesiologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Av. Doutor Arnaldo, 455, 2° andar, sala 2120, Cerqueira César, 01246-903, São Paulo, SP, Brazil. dfantoni@usp.br.|Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil, Avenida Prof. Orlando Marques Paiva, 87 Cidade Universitária, 05508-270, São Paulo, SP, Brazil. dfantoni@usp.br.
authors.forename: Denise Tabacchi
authors.initials: DT
authors.lastname: Fantoni
authors.affiliation: Laboratório de Investigação Médica 8, Anestesiologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Av. Doutor Arnaldo, 455, 2° andar, sala 2120, Cerqueira César, 01246-903, São Paulo, SP, Brazil. keilaida@usp.br.
authors.forename: Keila Kazue
authors.initials: KK
authors.lastname: Ida
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil, Avenida Prof. Orlando Marques Paiva, 87 Cidade Universitária, 05508-270, São Paulo, SP, Brazil. keilaida@gmail.com.
authors.forename: Thais Ingles
authors.initials: TI
authors.lastname: de Almeida
authors.affiliation: Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil, Avenida Prof. Orlando Marques Paiva, 87 Cidade Universitária, 05508-270, São Paulo, SP, Brazil. alinema10@usp.br.
authors.forename: Aline Magalhães
authors.initials: AM
authors.lastname: Ambrósio
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D006854:Hydrocortisone / Q000097:blood; D007660:Ketoprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D019647:Oral Surgical Procedures / Q000009:adverse effects / Q000662:veterinary*; D010149:Postoperative Pain / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D011422:Propionates / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009281:Naphthalenes; D011422:Propionates; D007660:Ketoprofen; C121784:2-(4-cyclohexyl-1-naphthalenyl)propanoic acid; D006854:Hydrocortisone