title: Runx2: Structure, function, and phosphorylation in osteoblast differentiation.
abstract: Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to various stimuli, the domains in Runx2 interact with several proteins and regulate a number of cellular events via posttranslational modifications. Hence, in this review we summarized the structural integrity of Runx2 and its posttranslational modifications, especially the phosphorylation responsible for either stimulation or inhibition of its regulatory role in osteogenesis.
authors.affiliation: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu -603 203, India.
authors.forename: S
authors.initials: S
authors.lastname: Vimalraj
authors.affiliation: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu -603 203, India.
authors.forename: B
authors.initials: B
authors.lastname: Arumugam
authors.affiliation: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu -603 203, India.
authors.forename: P J
authors.initials: PJ
authors.lastname: Miranda
authors.affiliation: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu -603 203, India. Electronic address: selvamurugan.n@ktr.srmuniv.ac.in.
authors.forename: N
authors.initials: N
authors.lastname: Selvamurugan
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D050659:Core Binding Factor Alpha 1 Subunit / Q000737:chemistry* / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism*; D010766:Phosphorylation; D013329:Structure-Activity Relationship
chemical_list: D050659:Core Binding Factor Alpha 1 Subunit
keywords: Bone; Osteoblast; Phosphorylation; Runx2