title: Arterial stiffness is increased in young normotensive subjects with high central blood pressure.
abstract: Information on high central blood pressure (CBP; HCP) in normotensive subjects (NT) and its relation to target organ damage (TOD) is not well established in young subjects. This study aimed to elucidate determinants of HCP and its relation with TOD. Anthropometrics, lab, brachial, and CBP were obtained on 430 normotensive subjects (NT; 16-24 years, 34% male, 44% Caucasian, 27% type 2 diabetes). HCP was defined as elevated CBP, with normal brachial BP. Subjects with HCP (prevalence, 16%) were more frequently female and African American, and had a higher prevalence of obesity and diabetes, a more adverse metabolic profile, higher levels of inflammation, brachial BP, central pulse pressure, and heart rate compared with NT. HCP also had evidence for TOD with a significant higher carotid intima media thickness, left ventricular mass, augmentation index, pulse wave velocity, and lower brachial distensibility than NT. HCP is related to early cardiac and vascular dysfunction and remain an independent predictor of TOD even after adjusting for cardiovascular risk factors.
authors.affiliation: Division of Internal Medicine and Hypertension Unit, Department of Medical Sciences, University of Turin, Turin, Italy. Electronic address: s.totaro84@gmail.com.
authors.forename: Silvia
authors.initials: S
authors.lastname: Totaro
authors.affiliation: Department of Pediatric Cardiology, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH.
authors.forename: Philip R
authors.initials: PR
authors.lastname: Khoury
authors.affiliation: Department of Pediatric Cardiology, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Kimball
authors.affiliation: Department of Pediatric Cardiology, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH.
authors.forename: Lawrence M
authors.initials: LM
authors.lastname: Dolan
authors.affiliation: Department of Pediatric Cardiology, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH.
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Urbina
mesh_terms: D000293:Adolescent; D000328:Adult; D044383:Black People / Q000706:statistics & numerical data; D001794:Blood Pressure / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology; D059168:Carotid Intima-Media Thickness; D002648:Child; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000503:physiopathology; D063177:Pulse Wave Analysis; D012737:Sex Factors; D013599:Systole / Q000502:physiology; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult; D001741:Black or African American
keywords: Central hypertension; pulse wave velocity