title: Body composition in chronic kidney disease.
abstract: OBJECTIVE
  To summarize the latest information on body composition among patients with chronic kidney disease and its association with outcomes.
  
  
  RESULTS
  Obesity is increasing among patients with end-stage renal disease and is more prevalent when direct measures of adiposity are used rather than BMI. High BMI is not associated with better survival among patients with earlier chronic kidney disease or after kidney transplantation, suggesting that excess fat is most protective among the sickest patients. Despite the positive association between BMI and survival among patients with end-stage renal disease, visceral fat is associated with coronary artery calcification and adverse cardiovascular events. Muscle wasting is prominent among patients with chronic kidney disease, sometimes even in the setting of obesity. Obesity and muscle wasting are associated with worse physical functioning. Indicators of low muscle size and strength are associated with higher mortality. Some interventions can affect body composition, but whether they affect survival has not been determined.
  
  
  CONCLUSIONS
  Recent studies show that a high BMI is not protective for all patients with chronic kidney disease and is associated with poor physical functioning and frailty. Visceral adiposity is associated with adverse cardiovascular outcomes. Sarcopenia is common among patients with end-stage renal disease and is associated with worse physical performance and higher mortality.
authors.affiliation: Division of Nephrology, University of California, San Francisco, California, USA.
authors.forename: Kirsten L
authors.initials: KL
authors.lastname: Johansen
authors.forename: Carol
authors.initials: C
authors.lastname: Lee
mesh_terms: D050154:Adiposity / Q000502:physiology*; D001823:Body Composition / Q000502:physiology*; D015992:Body Mass Index; D006801:Humans; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D006435:Renal Dialysis / Q000379:methods; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*