title: Evaluation of Oxidative Stress and hsCRP in Polycystic Ovarian Syndrome in a Tertiary Care Hospital.
abstract: PCOS is a heterogeneous endocrine disorder with diverse clinical presentation. Oxidative stress plays a key role in the pathophysiology of this disease. Serumhigh sensitive C-reactive protein (hsCRP), a marker of chronic low grade inflammation, is indicative of future development of cardiovascular disease. Our aim is to evaluate the oxidant status and hsCRP levels in PCOS. The study involved 61 cases and 61 controls in the age group of 18-40 years diagnosed with PCOS. Erythrocyte malondialdehyde (MDA), superoxide dismutase (SOD), serum hsCRP, gonadotrophins, thyroid stimulating hormone, prolactin, glycemic status and lipid profile were estimated. Erythrocyte MDA (p < 0.001), SOD (p = 0.007) and serum hsCRP (p < 0.001) were significantly elevated in PCOS patients than controls. Oxidative stress is present in women with PCOS along with elevated hsCRP.
authors.affiliation: Department of Biochemistry, Amrita School of Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwavidyapeetham, Ponekkara PO, Kochi, 682041 Kerala India.
authors.forename: N Unni C
authors.initials: NU
authors.lastname: Sumithra
authors.affiliation: Department of Obstetrics and Gynecology, Amrita School of Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwavidyapeetham, Ponekkara PO, Kochi, 682041 Kerala India.
authors.forename: R Lakshman
authors.initials: RL
authors.lastname: Lakshmi
authors.affiliation: Department of Biochemistry, Amrita School of Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwavidyapeetham, Ponekkara PO, Kochi, 682041 Kerala India.
authors.forename: N
authors.initials: N
authors.lastname: Leela Menon
authors.affiliation: Department of Biochemistry, Amrita School of Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwavidyapeetham, Ponekkara PO, Kochi, 682041 Kerala India.
authors.forename: K N
authors.initials: KN
authors.lastname: Subhakumari
authors.affiliation: Department of Biostatistics, Amrita School of Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwavidyapeetham, Ponekkara PO, Kochi, 682041 Kerala India.
authors.forename: V S
authors.initials: VS
authors.lastname: Sheejamol
keywords: Cardiovascular diseases; Free radicals; Oxidative stress; PCOS; Type 2 DM; hsCRP