title: Balancing the interests of patient data protection and medication safety monitoring in a public-private partnership.
abstract: Obtaining data without the intervention of a health care provider represents an opportunity to expand understanding of the safety of medications used in difficult-to-study situations, like the first trimester of pregnancy when women may not present for medical care. While it is widely agreed that personal data, and in particular medical data, needs to be protected from unauthorized use, data protection requirements for population-based studies vary substantially by country. For public-private partnerships, the complexities are enhanced. The objective of this viewpoint paper is to illustrate the challenges related to data protection based on our experiences when performing relatively straightforward direct-to-patient noninterventional research via the Internet or telephone in four European countries. Pregnant women were invited to participate via the Internet or using an automated telephone response system in Denmark, the Netherlands, Poland, and the United Kingdom. Information was sought on medications, other factors that may cause birth defects, and pregnancy outcome. Issues relating to legal controllership of data were most problematic; assuring compliance with data protection requirements took about two years. There were also inconsistencies in the willingness to accept nonwritten informed consent. Nonetheless, enrollment and data collection have been completed, and analysis is in progress. Using direct reporting from consumers to study the safety of medicinal products allows researchers to address a myriad of research questions relating to everyday clinical practice, including treatment heterogeneity in population subgroups not traditionally included in clinical trials, like pregnant women, children, and the elderly. Nonetheless, there are a variety of administrative barriers relating to data protection and informed consent, particularly within the structure of a public-private partnership.
authors.affiliation: Quintiles Real-World & Late-Phase Research, Scientific Affairs, Cambridge, MA, United States. nancy.dreyer@quintiles.com.
authors.forename: Nancy A
authors.identifier: http://orcid.org/0000-0003-0153-8286
authors.initials: NA
authors.lastname: Dreyer
authors.forename: Stella
authors.identifier: http://orcid.org/0000-0001-5937-1277
authors.initials: S
authors.lastname: Blackburn
authors.forename: Valerie
authors.identifier: http://orcid.org/0000-0002-1252-0033
authors.initials: V
authors.lastname: Hliva
authors.forename: Shahrul
authors.identifier: http://orcid.org/0000-0002-7163-8402
authors.initials: S
authors.lastname: Mt-Isa
authors.forename: Jonathan
authors.identifier: http://orcid.org/0000-0003-3494-9559
authors.initials: J
authors.lastname: Richardson
authors.forename: Anna
authors.identifier: http://orcid.org/0000-0001-6102-4274
authors.initials: A
authors.lastname: Jamry-Dziurla
authors.forename: Alison
authors.identifier: http://orcid.org/0000-0002-0005-9016
authors.initials: A
authors.lastname: Bourke
authors.forename: Rebecca
authors.identifier: http://orcid.org/0000-0002-2510-9796
authors.initials: R
authors.lastname: Johnson
keywords: Internet; data protection; ethics; pharmacovgilance; pregnancy; public-private partnerships