title: Genome-wide QTL analysis of meat quality-related traits in a large F2 intercross between Landrace and Korean native pigs.
abstract: BACKGROUND
  We conducted a genome-wide linkage analysis to identify quantitative trait loci (QTL) that influence meat quality-related traits in a large F2 intercross between Landrace and Korean native pigs. Thirteen meat quality-related traits of the m. longissimus lumborum et thoracis were measured in more than 830 F2 progeny. All these animals were genotyped with 173 microsatellite markers located throughout the pig genome, and the GridQTL program based on the least squares regression model was used to perform the QTL analysis.
  
  
  RESULTS
  We identified 23 genome-wide significant QTL in eight chromosome regions (SSC1, 2, 6, 7, 9, 12, 13, and 16) (SSC for Sus Scrofa) and detected 51 suggestive QTL in the 17 chromosome regions. QTL that affect 10 meat quality traits were detected on SSC12 and were highly significant at the genome-wide level. In particular, the QTL with the largest effect affected crude fat percentage and explained 22.5% of the phenotypic variance (F-ratio = 278.0 under the additive model, nominal P = 5.5 × 10(-55)). Interestingly, the QTL on SSC12 that influenced meat quality traits showed an obvious trend for co-localization.
  
  
  CONCLUSIONS
  Our results confirm several previously reported QTL. In addition, we identified novel QTL for meat quality traits, which together with the associated positional candidate genes improve the knowledge on the genetic structure that underlies genetic variation for meat quality traits in pigs.
authors.affiliation: Subtropical Animal Experiment Station, National Institute of Animal Science, Rural Development Administration, Jeju, 690-150, Korea. choic4753@korea.kr.
authors.forename: In-Cheol
authors.initials: IC
authors.lastname: Cho
authors.affiliation: Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, 660-701, Korea. yck1985@gnu.ac.kr.|Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Korea. yck1985@gnu.ac.kr.
authors.forename: Chae-Kyoung
authors.initials: CK
authors.lastname: Yoo
authors.affiliation: Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, 660-701, Korea. bilf@gnu.ac.kr.|Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Korea. bilf@gnu.ac.kr.
authors.forename: Jae-Bong
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, 660-701, Korea. ejjung@gnu.ac.kr.|Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Korea. ejjung@gnu.ac.kr.
authors.forename: Eun-Ji
authors.initials: EJ
authors.lastname: Jung
authors.affiliation: Subtropical Animal Experiment Station, National Institute of Animal Science, Rural Development Administration, Jeju, 690-150, Korea. hansh04@naver.com.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Han
authors.affiliation: Subtropical Animal Experiment Station, National Institute of Animal Science, Rural Development Administration, Jeju, 690-150, Korea. lee6470@korea.kr.
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Lee
authors.affiliation: Subtropical Animal Experiment Station, National Institute of Animal Science, Rural Development Administration, Jeju, 690-150, Korea. koms21c@korea.kr.
authors.forename: Moon-Suck
authors.initials: MS
authors.lastname: Ko
authors.affiliation: Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, 660-701, Korea. s_htim@gnu.ac.kr.|Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Korea. s_htim@gnu.ac.kr.
authors.forename: Hyun-Tae
authors.initials: HT
authors.lastname: Lim
authors.affiliation: Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, 660-701, Korea. heebok.park@cnu.ac.kr.|Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Korea. heebok.park@cnu.ac.kr.|Department of Animal Science and Biotechnology (BK21 plus program), College of Agriculture and Life Sciences, Chungnam National University, Daejeon, 305-764, Korea. heebok.park@cnu.ac.kr.
authors.forename: Hee-Bok
authors.initials: HB
authors.lastname: Park
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D008040:Genetic Linkage; D014644:Genetic Variation / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D018895:Microsatellite Repeats / Q000235:genetics; D010641:Phenotype; D040641:Quantitative Trait Loci; D000069466:Red Meat; D034421:Sus scrofa / Q000145:classification / Q000235:genetics*