title: NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma with late distant metastases.
abstract: We present two cases of meningeal solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) with immunohistochemistry of STAT6 and analysis of NAB2-STAT6 fusion genes. Case 1 was a 37-year-old male with a left middle fossa tumor; case 2 was a 68-year-old female with a cerebellar tumor. They showed late metastasis to the lung or bone 8 or 13 years, respectively, after the first surgery. Histology of both primary and metastatic tumors showed a cellular hemangiopericytomatous pattern with nuclear atypia. The primary tumors showed nuclear staining of STAT6, but both metastatic tumors showed nuclear and cytoplasmic STAT6. DNA sequencing revealed two kinds of NAB2-STAT6 fusion genes. One consisted of exon 6 of NAB2, intron 6 of NAB2, and the middle of exon 17 of STAT6 (observed in the primary and metastatic tumors of case 1); the other consisted of exon 6 of NAB2 and the beginning of exon 17 of STAT6 (observed in the metastatic tumor of case 2). The primary tumor of case 2 had both fusion genes. To the best of our knowledge, we are the first to report NAB2-STAT6 fusion gene analysis in primary and metastatic meningeal SFT/HPCs and a case showed different fusion gene status in the metastatic tumor.
authors.affiliation: Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Uchinada, Kanazawa, Ishikawa, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Nakada
authors.affiliation: Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Uchinada, Kanazawa, Ishikawa, Japan. hminato@kanazawa-med.ac.jp.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Minato
authors.affiliation: Department of Life Science, Medical Research Institute, Kanazawa Medical University, Kanazawa, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takegami
authors.affiliation: Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Uchinada, Kanazawa, Ishikawa, Japan.
authors.forename: Nozomu
authors.initials: N
authors.lastname: Kurose
authors.affiliation: Section of Diagnostic Pathology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ikeda
authors.affiliation: Department of Pathology, Kanazawa Municipal Hospital, Kanazawa, Ishikawa, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Department of Neurosurgery, Kanazawa Medical University, Kanazawa, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sasagawa
authors.affiliation: Department of Neurosurgery, Kanazawa Medical University, Kanazawa, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Akai
authors.affiliation: Department of Orthopedics, Kanazawa University Hospital, Kanazawa, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kato
authors.affiliation: Department of Orthopedics, Kanazawa University Hospital, Kanazawa, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Yamamoto
authors.affiliation: Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Uchinada, Kanazawa, Ishikawa, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nojima
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000235:genetics / Q000556:secondary; D002528:Cerebellar Neoplasms / Q000235:genetics* / Q000473:pathology*; D035301:Cranial Fossa, Middle; D005091:Exons; D005260:Female; D050939:Gene Fusion; D006393:Hemangiopericytoma / Q000235:genetics* / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary; D008297:Male; D012097:Repressor Proteins / Q000032:analysis / Q000235:genetics*; D050800:STAT6 Transcription Factor / Q000032:analysis / Q000235:genetics*; D019292:Skull Base Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: C491000:NAB2 protein, human; D012097:Repressor Proteins; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human
keywords: Hemangiopericytoma; Immunohistochemistry; Meningeal tumor; NAB2–STAT6 fusion gene; Solitary fibrous tumor