title: Simulation of DSB yield for high LET radiation.
abstract: A simulation approach for the calculation of the LET-dependent yield of double-strand breaks (DSB) is presented. The model considers DSB formed as two close-lying single-strand breaks (SSB), whose formation is mediated by both intra-track processes (single electrons) or at local doses larger than about 1000 Gy in particle tracks also by electron inter-track processes (two independent electron tracks). A Monte Carlo algorithm and an analytical formula for the DSB yield are presented. The approach predicts that the DSB yield is enhanced after charged particle irradiation of high LET compared with X-ray or gamma radiation. It is used as an inherent part of the local effect model, which is applied to estimate the relative biological effectiveness of high LET radiation.
authors.affiliation: Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany t.friedrich@gsi.de.
authors.forename: T
authors.initials: T
authors.lastname: Friedrich
authors.affiliation: Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany Institut für Festkörperphysik, Technische Universität Darmstadt, Darmstadt, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Durante
authors.affiliation: Biophysics Department, GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Scholz
mesh_terms: D003198:Computer Simulation; D053903:DNA Breaks, Double-Stranded / Q000528:radiation effects*; D004583:Electrons; D005720:Gamma Rays; D018499:Linear Energy Transfer / Q000528:radiation effects*; D009010:Monte Carlo Method; D012062:Relative Biological Effectiveness; D014965:X-Rays