title: Association between CC motif chemokine ligand 5 (CCL5) polymorphisms and asthma risk: an updated meta-analysis.
abstract: BACKGROUND
  Findings regarding the associations between the CC motif chemokine ligand 5 (CCL5) -403G/A and -28C/G polymorphisms and asthma risk are controversial.We performed a meta-analysis to determine whether CCL5 polymorphisms are associated with asthma risk.
  
  
  METHODS
  We searched the Pubmed, Embase, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies published before June 2013. The strength of associations was calculated using ORs with 95% CIs.
  
  
  RESULTS
  Twenty case-control studies were included in this meta-analysis. We did not observe a significant association between the CCL5 -403G/A polymorphism and asthma risk (OR, 1.10; 95% CI, 0.93-1.30; P = .25). The CCL5 - 28C/G polymorphism, however, was associated with a significantly elevated asthma risk (OR, 1.17; 95% CI, 1.02-1.33; P = .02). Subgroup analyses found that the CCL5 -28C/G polymorphism was significantly associated with asthma risk in Asians (OR, 1.16; 95% CI, 1.01-1.33; P = .04) and children (OR, 1.29; 95% CI, 1.03-1.63; P = .03).
  
  
  CONCLUSIONS
  This meta-analysis suggests that the CCL5 -28C/G polymorphism is a risk factor for asthma.
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.forename: W
authors.initials: W
authors.lastname: Nie
authors.forename: Y
authors.initials: Y
authors.lastname: Zang
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Xiu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics*; D002648:Child; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C483024:CCL5 protein, human; D018946:Chemokine CCL5