title: A vaccine against Ebola: Problems and opportunities.
abstract: The unprecedented dimensions of the 2014 Ebola epidemic which ravaged 3 West African countries have challenged public health response capacity and urged the availability of safe and effective vaccines. In this context, vectored vaccines already tested in animal models have undergone phase 1 studies in human beings and are now ready for efficacy evaluation in large scale trials. Health care workers and other frontline caregivers are likely to be the target population for both vaccine trials and vaccination campaigns. However, methodological and ethical issues should be considered in plans concerning the conduction of clinical trials and the possible use of licensed vaccines against Ebola.
authors.affiliation: a Department of Infectious, Parasitic, and Immunomediated Diseases; Istituto Superiore di Sanità ; Roma , Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Rezza
mesh_terms: D000354:Africa, Western / Q000453:epidemiology; D017321:Clinical Trials, Phase I as Topic; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D046129:Ebola Vaccines / Q000009:adverse effects / Q000276:immunology*; D019142:Hemorrhagic Fever, Ebola / Q000517:prevention & control*; D006801:Humans
chemical_list: D046129:Ebola Vaccines
keywords: Ebola; epidemiology; ethics; study design; vectored vaccine