title: [Clinical evaluation of ocriplasmin as a vitreolytic agent].
abstract: Incomplete perifoveal posterior vitreous detachment (PVD) associated with abnormal vitreomacular adhesion (VMA) can cause vitreomacular traction (VMT) and macular hole (MH) formation, which require vitrectomy treatment. Pharmacologic vitreolysis, which is intravitreal injection with vitreolytic enzymes to resolve VMA, may be used as an alternative therapy.Ocriplasmin, formerly known as microplasmin, is a recombinant truncated form of plasmin with proteolytic activity against fibronectin and laminin.It was recently approved for VMA treatment in the European Union and USA. Phase III studies indicated that ocriplasmin injection was a safe and effective treatment for selected cases of symptomatic VMA and MH. VMA release was achieved in 26.5% of ocriplasmin-injected eyes versus 10.1% of the placebo group. MH closure was achieved in 40.6% as compared with 10.6% of the placebo group.In comparison with the outcome after vitrectomy, the success rate of ocriplasmin was still far below expectation. Ocular adverse events included vitreous floaters, photopsia and profound visual decline. Its efficacy and safety need to be further evaluated in more clinical trials.
authors.affiliation: Department of Ophthalmology, Xijing Hospital, The Fourth Military Medical University, The Eye Institute of PLA, Xi'an 710032, China.
authors.forename: Luxi
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Xijing Hospital, The Fourth Military Medical University, The Eye Institute of PLA, Xi'an 710032, China. Email: dhj2020@fmmu.edu.cn.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Du
authors.affiliation: Department of Ophthalmology, Xijing Hospital, The Fourth Military Medical University, The Eye Institute of PLA, Xi'an 710032, China.
authors.forename: Manhong
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, Xijing Hospital, The Fourth Military Medical University, The Eye Institute of PLA, Xi'an 710032, China.
authors.forename: Yannian
authors.initials: Y
authors.lastname: Hui
mesh_terms: D017326:Clinical Trials, Phase III as Topic; D005128:Eye Diseases / Q000188:drug therapy*; D005341:Fibrinolysin / Q000009:adverse effects / Q000627:therapeutic use*; D005353:Fibronectins / Q000187:drug effects; D006801:Humans; D058449:Intravitreal Injections; D007797:Laminin / Q000187:drug effects; D010446:Peptide Fragments / Q000009:adverse effects / Q000627:therapeutic use*; D012167:Retinal Perforations / Q000188:drug therapy* / Q000209:etiology; D000267:Tissue Adhesions / Q000188:drug therapy; D016896:Treatment Outcome; D014821:Vitrectomy; D014822:Vitreous Body; D020255:Vitreous Detachment / Q000150:complications*
chemical_list: D005353:Fibronectins; D007797:Laminin; D010446:Peptide Fragments; C054561:microplasmin; D005341:Fibrinolysin