title: [Experience of Pneumo 23 vaccine in patients with combination of COLD with pneumoconiosis].
abstract: The most well-studied, but not single factor of COLD development is smoking. Occupational hazards as organic and inorganic dust are underevaluated risk factor of COLD. Smoking increased unfavorable effects of occupational hazards. Interesting for the study are the patients with combination of pneumoconiosis and COLD, severe concomitant diseases and decompensated complications--chronic cardiac failure and chronic lung failure. These patients have lower life quality, more frequent infectious exacerbations of COLD and pneumonias--that remains a significant medical and social problem. At present, pneumonia occupies 4-5th place in lethal outcomes structure. Pneumo 23--polysaccharide 23-valent vaccine--covers main serotypes of pneumococcus causing diseases of severe clinical course. In the study, the patients were injected with Pneumo 23 along with basic COLD therapy, were observed over 5 years and demonstrated reliable decrease of acute respiratory infections, COLD exacerbations and pneumonias. Those exacerbations and pneumonias had less severe course. Number of the exacerbations requiring hospitalization also decreased.
authors.forename: O V
authors.initials: OV
authors.lastname: Rodionova
authors.forename: G L
authors.initials: GL
authors.lastname: Ignatova
authors.forename: E V
authors.initials: EV
authors.lastname: Blinova
authors.forename: I V
authors.initials: IV
authors.lastname: Grebneva
authors.forename: V N
authors.initials: VN
authors.lastname: Antonov
mesh_terms: D000368:Aged; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000494:pharmacology*; D011009:Pneumoconiosis / Q000453:epidemiology / Q000628:therapy*; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology / Q000628:therapy*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: C414006:23-valent pneumococcal capsular polysaccharide vaccine; D022242:Pneumococcal Vaccines