title: The PLORAS Database: A data repository for Predicting Language Outcome and Recovery After Stroke.
abstract: The PLORAS Database is a relational repository of anatomical and functional imaging data that has primarily been acquired from stroke survivors, along with standardized scores on a wide range of sensory, motor and cognitive abilities, demographic details and medical history. As of January 2015, we have data from 750 patients with an expected accrual rate of 200 patients per year. Expansion will accelerate as we extend our collaborations. The main aim of the database is to Predict Language Outcome and Recovery After Stroke (PLORAS) on the basis of a single structural (anatomical) brain scan that indexes the stereotactic location and extent of brain damage. Predictions are made for individual patients by indicating how other patients with the most similar brain damage, cognitive abilities and demographic details recovered their language skills over time. Predictions are validated by longitudinal follow-ups of patients who initially presented with speech and language difficulties. The PLORAS Database can also be used to predict recovery of other cognitive abilities on the basis of anatomical brain scans. The functional imaging data can be used to understand the neural mechanisms that support recovery from brain damage; and all the data can be used to understand the main sources of inter-subject variability in structure-function mappings in the human brain. Data will be made available for sharing, subject to: funding, ethical approval and patient consent.
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Mohamed L
authors.initials: ML
authors.lastname: Seghier
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Elnas
authors.initials: E
authors.lastname: Patel
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Susan
authors.initials: S
authors.lastname: Prejawa
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Sue
authors.initials: S
authors.lastname: Ramsden
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Andre
authors.initials: A
authors.lastname: Selmer
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Louise
authors.initials: L
authors.lastname: Lim
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Browne
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Johanna
authors.initials: J
authors.lastname: Rae
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Zula
authors.initials: Z
authors.lastname: Haigh
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Deborah
authors.initials: D
authors.lastname: Ezekiel
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Thomas M H
authors.initials: TMH
authors.lastname: Hope
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK.
authors.forename: Alex P
authors.initials: AP
authors.lastname: Leff
authors.affiliation: Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK. Electronic address: c.j.price@ucl.ac.uk.
authors.forename: Cathy J
authors.initials: CJ
authors.lastname: Price
mesh_terms: D001921:Brain / Q000473:pathology; D003071:Cognition; D016208:Databases, Factual; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007806:Language Disorders / Q000209:etiology / Q000534:rehabilitation*; D008279:Magnetic Resonance Imaging; D011379:Prognosis; D011786:Quality Control; D020127:Recovery of Function; D013064:Speech Disorders / Q000209:etiology / Q000534:rehabilitation; D020521:Stroke / Q000473:pathology / Q000523:psychology*; D000071939:Stroke Rehabilitation; D016896:Treatment Outcome