title: The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining Linker for Activation of T Cells (LAT) Activation via TRAF6 Protein.
abstract: Herpes simplex virus 1 (HSV-1) is the most prevalent human virus and causes global morbidity because the virus is able to infect multiple cell types. Remarkably, HSV infection switches between lytic and latent cycles, where T cells play a critical role. However, the precise way of virus-host interactions is incompletely understood. Here we report that HSV-1 productively infected Jurkat T-cells and inhibited antigen-induced T cell receptor activation. We discovered that HSV-1-encoded Us3 protein interrupted TCR signaling and interleukin-2 production by inactivation of the linker for activation of T cells. This study unveils a mechanism by which HSV-1 intrudes into early events of TCR-mediated cell signaling and may provide novel insights into HSV infection, during which the virus escapes from host immune surveillance.
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Songfang
authors.initials: S
authors.lastname: Wu
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Pan
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Bei
authors.initials: B
authors.lastname: Lan
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Yaohui
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Qianli
authors.initials: Q
authors.lastname: Leng
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China.
authors.forename: Da
authors.initials: D
authors.lastname: Chen
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China. Electronic address: czz912@aliyun.com.
authors.forename: Cuizhu
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612. Electronic address: tshuo@uic.edu.
authors.forename: Bin
authors.initials: B
authors.lastname: He
authors.affiliation: Key laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China. Electronic address: caoyj@nankai.edu.cn.
authors.forename: Youjia
authors.initials: Y
authors.lastname: Cao
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000276:immunology*; D006561:Herpes Simplex / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology; D019169:Jurkat Cells; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000821:virology; D048029:TNF Receptor-Associated Factor 6 / Q000235:genetics / Q000276:immunology*; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C508594:IL2 protein, human; D007376:Interleukin-2; C110810:LAT protein, human; D008565:Membrane Proteins; D011948:Receptors, Antigen, T-Cell; D048029:TNF Receptor-Associated Factor 6; D014764:Viral Proteins; D017346:Protein Serine-Threonine Kinases; C095207:US3 protein, Human herpesvirus 1
keywords: HSV-1; LAT; TCR; TRAF6; Us3; interleukin; signaling; ubiquitination