title: Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study.
abstract: It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.
authors.affiliation: *Department of Psychiatry, University of Cambridge, National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre and NIHR Collaboration for Leadership in Applied Health Research & Care, Cambridge, UK; †Centre for Epidemiology and Public Health, Health Service and Population Research Department, Institute of Psychiatry, King's College, London, UK; ‡Department of Psychiatry and Psychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands; §Department of Psychological Medicine, Institute of Psychiatry, King's College, London, UK; ∥Department of Psychiatry, Trinity College, Dublin, Ireland; ¶NIHR Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College, London, UK; #Psychosis Studies Department, Institute of Psychiatry, King's College, London, UK; **Division of Psychiatry and Applied Psychology, University of Nottingham, Nottingham, UK; ††Department of Nursing and Midwifery, University of Dundee, Dundee, UK; ‡‡Centre for Economics of Mental and Physical Health, Health Service and Population Research Department, Institute of Psychiatry, King's College, London, UK; §§Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience at King's College, London, UK; ∥∥Institute of Psychiatry, Psychology & Neuroscience at King's College, London, UK; ¶¶Department of Psychiatry, University of New South Wales, Sydney, NSW, Australia; ##Division of Psychiatry, University College London, London, UK; and ***Addictions Department, Institute of Psychiatry, King's College, London, UK.
authors.forename: Camice J
authors.initials: CJ
authors.lastname: Revier
authors.forename: Ulrich
authors.initials: U
authors.lastname: Reininghaus
authors.forename: Rina
authors.initials: R
authors.lastname: Dutta
authors.forename: Paul
authors.initials: P
authors.lastname: Fearon
authors.forename: Robin M
authors.initials: RM
authors.lastname: Murray
authors.forename: Gillian A
authors.initials: GA
authors.lastname: Doody
authors.forename: Tim
authors.initials: T
authors.lastname: Croudace
authors.forename: Paola
authors.initials: P
authors.lastname: Dazzan
authors.forename: Margaret
authors.initials: M
authors.lastname: Heslin
authors.forename: Adanna
authors.initials: A
authors.lastname: Onyejiaka
authors.forename: Eugenia
authors.initials: E
authors.lastname: Kravariti
authors.forename: Julia
authors.initials: J
authors.lastname: Lappin
authors.forename: Ben
authors.initials: B
authors.lastname: Lomas
authors.forename: James B
authors.initials: JB
authors.lastname: Kirkbride
authors.forename: Kim
authors.initials: K
authors.lastname: Donoghue
authors.forename: Craig
authors.initials: C
authors.lastname: Morgan
authors.forename: Peter B
authors.initials: PB
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D017028:Caregivers / Q000523:psychology; D002423:Cause of Death; D015331:Cohort Studies; D004739:England; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011618:Psychotic Disorders / Q000175:diagnosis / Q000401:mortality / Q000523:psychology* / Q000628:therapy*; D012559:Schizophrenia / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D012565:Schizophrenic Psychology; D012917:Social Adjustment; D016019:Survival Analysis; D055815:Young Adult