title: Optimizing research animal necropsy and histology practices.
abstract: Reduction in animal numbers is an important tenet of laboratory animal research. Research animals should undergo complete necropsy at the close of a study to yield valuable information about the effects and safety of experimental manipulations. Proper and thorough tissue collection, storage and assessment are paramount in attaining the most efficient use of animals in research.
authors.affiliation: US Food and Drug Administration, Silver Spring, MD.
authors.forename: Victoria
authors.initials: V
authors.lastname: Hampshire
authors.forename: Marian
authors.initials: M
authors.lastname: Rippy
mesh_terms: D032761:Animal Experimentation / Q000592:standards*; D000818:Animals; D000830:Animals, Laboratory; D001344:Autopsy / Q000592:standards / Q000662:veterinary*; D006652:Histological Techniques / Q000592:standards / Q000662:veterinary*