title: Serotonin transporter gene polymorphisms: Relation with platelet serotonin level in patients with primary Sjogren's syndrome.
abstract: Significantly lower platelet serotonin level (PSL) in patients with primary Sjogren's syndrome (pSS) than in healthy controls has been reported in our prior studies. In the present report, we demonstrated effect of functional polymorphisms in the serotonin transporter gene (5-HTT) on PSL. We describe a group of 61 pSS patients and 100 healthy individuals subjects, who received PSL measurement in our prior study. All subjects were genotyped for the promoter 5-HTTLPR (L/S), rs25531 (A/G) and intronic 5-HTTVNTRin2 (l/s) polymorphisms. Overall, the presence of 5-HTTVNTRin2 ss genotype was associated with significantly lower PSL in pSS patients, not in healthy controls. Reduced PSL in pSS patients is in line with hypothesis of association between chronic immunoinflammation and 5-HT system dysregulation, identifying additional mechanisms such as altered 5-HT transport as potential genetic factor contributing to PSL depletion.
authors.affiliation: Medical School University of Zagreb, Department of Internal Medicine, University Hospital Sestre milosrdnice, HR-Vinogradska cesta 29, 10000 Zagreb, Croatia.
authors.forename: J
authors.initials: J
authors.lastname: Markeljevic
authors.affiliation: Department of Neurology, University Clinical Hospital Centre Zagreb, HR-Kispaticeva 12, 10000 Zagreb, Croatia; Croatian Institute for Brain Research, Medical School University of Zagreb, HR-Salata 12, 10000 Zagreb, Croatia. Electronic address: helenasarac57@gmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Sarac
authors.affiliation: Medical School University of Zagreb, University Hospital Zagreb, Department of Laboratory Diagnostic, HR-Kispaticeva 12, 10000 Zagreb, Croatia.
authors.forename: N
authors.initials: N
authors.lastname: Bozina
authors.affiliation: Croatian Institute for Brain Research, Medical School University of Zagreb, HR-Salata 12, 10000 Zagreb, Croatia.
authors.forename: N
authors.initials: N
authors.lastname: Henigsberg
authors.affiliation: Institute of Immunology, HR-Rockefellerova 2, HR-10000 Zagreb, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Simic
authors.affiliation: Rudjer Boskovic Institute, Laboratory for Neurochemistry and Molecular Neurobiology, Department of Molecular Biology, HR-Bijenicka 54, 10000 Zagreb, Croatia.
authors.forename: L
authors.initials: L
authors.lastname: Cicin Sain
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012189:Retrospective Studies; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012859:Sjogren's Syndrome / Q000097:blood* / Q000235:genetics*; D055815:Young Adult
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin
keywords: 5-HTTLPR/rs25531; 5-HTTVNTRin2; Platelet serotonin; Serotonin transporter polymorphism; Sjogren syndrome