title: Chronic stress, inflammation, and glucose regulation in U.S. Hispanics from the HCHS/SOL Sociocultural Ancillary Study.
abstract: Diabetes prevalence is rising rapidly, and diabetes disproportionately affects Hispanics and other underserved groups. Chronic stress may contribute to diabetes risk, but few studies have examined this relationship in U.S. Hispanics. We examined associations of chronic stress with fasting glucose, glucose tolerance, and glycosylated hemoglobin (HbA1c) in Hispanics without diabetes, and also assessed indirect effects of stress through inflammation (CRP). Participants were 3,923 men and women, aged 18-74, without diabetes, from the four U.S. field centers (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA) of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary study. Participants completed a measure of chronic life stress and a physical exam with oral glucose tolerance test. In a multivariate regression analysis with adjustment for demographic and health covariates, higher chronic stress was related to higher fasting glucose (standardized regression coefficient: β = .09, p < .01), postload glucose (β = .07, p < .05), and HbA1c levels (β = .08, p < .01). However, there was no indirect effect of stress through inflammation. Findings suggest that higher chronic stress is associated with poorer glucose regulation in Hispanics, prior to the onset of a clinical diabetes diagnosis.
authors.affiliation: SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, California, USA.
authors.forename: Jessica L
authors.initials: JL
authors.lastname: McCurley
authors.affiliation: Department of Psychiatry, University of California, San Diego, San Diego, California, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Mills
authors.affiliation: Department of Psychology, San Diego State University, San Diego, California, USA.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Roesch
authors.affiliation: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Carnethon
authors.affiliation: SDSU/UCSD Joint Doctoral Program in Global Health, San Diego, California, USA.
authors.forename: Rebeca E
authors.initials: RE
authors.lastname: Giacinto
authors.affiliation: Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA.
authors.forename: Carmen R
authors.initials: CR
authors.lastname: Isasi
authors.affiliation: Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Teng
authors.affiliation: Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Sotres-Alvarez
authors.affiliation: Department of Psychology, University of Miami, Coral Gables, Florida, USA.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Llabre
authors.affiliation: Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Penedo
authors.affiliation: Department of Psychology, University of Miami, Coral Gables, Florida, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Schneiderman
authors.affiliation: Department of Psychology, San Diego State University, San Diego, California, USA.
authors.forename: Linda C
authors.initials: LC
authors.lastname: Gallo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D018149:Glucose Intolerance / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006306:Health Surveys; D006630:Hispanic or Latino; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013315:Stress, Psychological / Q000378:metabolism*; D014481:United States; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Glucose; Hispanic; Inflammation; Insulin; Stress