title: [Synthesis and cytotoxicity of allobetulin derivatives].
abstract: The synthesis and screening of antitumor activity in vitro (cytotoxicity) of various oxygen, nitrogen, sulfur and platinum-containing derivatives of allobetulin, including different arrangements of the double bonds in the A and B rings, penta- and hexacyclic ring A, 21-acetyl-20,28-epoxy-18α,19βH-ursane-isomeric cycle E, was carry out. (3R,5R)-19β,28-Epoxy-4,5-seco-18α-olean-3(5)-ozonide and 2,3-indolo-21β-acetyl-20β,28-epoxy-18α, H-19β-ursane showed significant cytotoxic activity against melanoma MeWo and Leukemia SR cells, appropriately. (3S,5S)-Diastereomer of the first compound showed no cytotoxicity.
authors.forename: O B
authors.initials: OB
authors.lastname: Kazakova
authors.forename: I E
authors.initials: IE
authors.lastname: Smirnova
authors.forename: E F
authors.initials: EF
authors.lastname: Khusnutdinova
authors.forename: O S
authors.initials: OS
authors.lastname: Zhukova
authors.forename: L V
authors.initials: LV
authors.lastname: Fetisova
authors.forename: G N
authors.initials: GN
authors.lastname: Apryshko
authors.forename: N I
authors.initials: NI
authors.lastname: Medvedeva
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Iamansarov
authors.forename: I P
authors.initials: IP
authors.lastname: Baĭkova
authors.forename: Thanh Tra
authors.initials: TT
authors.lastname: Nguen
authors.forename: Do Thi  H
authors.initials: do T
authors.lastname: Thu
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000094062:Betulinic Acid
chemical_list: D014315:Triterpenes; C002503:betulin; D000094062:Betulinic Acid