title: A facile route for rapid synthesis of hollow mesoporous silica nanoparticles as pH-responsive delivery carrier.
abstract: In this paper, a facile and effective route has been developed for rapid synthesis of hollow mesoporous silica nanoparticles (HMSNs) by using tetradecyltrimethylammonium bromide (TTAB) as the porogen with the assistance of triethanolamine (TEA). The products were characterized by various techniques including TEM, SEM, BET, and FT-IR, etc. The HMSNs obtained possess spherical morphology, mesoporous channels and very high specific surface areas (1355m(2)g(-1)). According to the experimental results, a possible formation mechanism was discussed. Moreover, the ability of HMSNs as drug carrier was evaluated by selecting doxorubicin hydrochloride (DOX) as the model drug. The results indicated that HMSNs showed high loading capacity and controlled pH-responsive release behavior. Considering their unique nanostructures and porous properties, we expect the HMSNs prepared have more potential applications in various fields such as nanoreactors, cellular imaging, and biosensor.
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Xu
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China. Electronic address: hjzhang128@shu.edu.cn.
authors.forename: Haijiao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Donghai
authors.initials: D
authors.lastname: Wang
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wu
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Xingwen
authors.initials: X
authors.lastname: Liu
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China. Electronic address: zjiao@shu.edu.cn.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiao
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D050337:Trimethyl Ammonium Compounds / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D003692:Delayed-Action Preparations; D050337:Trimethyl Ammonium Compounds; D012822:Silicon Dioxide; D004317:Doxorubicin; C009410:tetradecyltrimethylammonium
keywords: Drug delivery; Hollow mesoporous silica nanoparticles (HMSNs); Self-assembly; Tetradecyltrimethylammonium bromide (TTAB)