title: Postprandial triglyceride response in normolipidemic, hyperlipidemic and obese subjects - the influence of polydextrose, a non-digestible carbohydrate.
abstract: BACKGROUND
  Three independent trials were conducted to evaluate postprandial triglyceride (TG) responses in subjects with different lipid metabolism. The effect of polydextrose (PDX), a soluble non-digestible carbohydrate, on postprandial response was also studied using practically relevant, high fat meal interventions.
  
  
  METHODS
  A total of 19 normolipidemic (average BMI 24.1 kg/m(2)), 21 overweight/hyperlipidemic (average BMI 29.6 kg/m(2)) and 18 obese/non-diabetic subjects (average BMI 33.6 kg/m(2)) were included in the study. On two separate occasions all subjects ate two high-fat meals (4293 kJ, 36% from fat), one with PDX (either 12.5 g or 15 g) and one without PDX during placebo-controlled, double-blind, crossover and randomized trials. To obtain the triglyceride measurements venous blood samples were taken before the consumption of the test meal and five times afterwards, up to 6 h post-test meal. The triglyceride responses were modeled using a mixed-effects linear model.
  
  
  RESULTS
  The key variables that explain the variation of the postprandial triglyceride response in the different subject groups were: baseline triglyceride concentration, time point, and PDX vs. placebo treatment (p < 0.05). The maximum postprandial TG concentration was more pronounced in hyperlipidemic group compared to normolipidemic (p < 0.001) or obese groups (p < 0.01). The modeled TG response analysis showed that irrespective of the study population PDX supplementation was one of the factors significantly reducing triglyceride response compared to the placebo treatment (p < 0.05).
  
  
  CONCLUSIONS
  Subjects with elevated fasting triglyceride levels display exaggerated and prolonged postprandial triglyceride responses. PDX, a soluble non-digestible carbohydrate, may offer a dietary concept for reducing the postprandial triglyceride response after the consumption of a meal containing a high concentration of fat.
authors.affiliation: DuPont Nutrition and Health, Active Nutrition, Sokeritehtaantie 20, FI-02460, Kantvik, Finland. kirsti.tiihonen@dupont.com.
authors.forename: Kirsti
authors.initials: K
authors.lastname: Tiihonen
authors.affiliation: Danisco Health and Nutrition, Kantvik, Finland. nrautonen@gmail.com.
authors.forename: Nina
authors.initials: N
authors.lastname: Rautonen
authors.affiliation: Avoltus Oy, Turku, Finland. esa.alhoniemi@avoltus.com.
authors.forename: Esa
authors.initials: E
authors.lastname: Alhoniemi
authors.affiliation: MCA Research Laboratory, University of Turku, Turku, Finland. res.lab@mca.inet.fi.
authors.forename: Markku
authors.initials: M
authors.lastname: Ahotupa
authors.affiliation: DuPont Nutrition and Health, Reigate, UK. julian.stowell@dupont.com.
authors.forename: Julian
authors.initials: J
authors.lastname: Stowell
authors.affiliation: UKK Institute for Health Promotion Research, Tampere, Finland. tommi.vasankari@uta.fi.
authors.forename: Tommi
authors.initials: T
authors.lastname: Vasankari
mesh_terms: D000328:Adult; D015992:Body Mass Index; D018592:Cross-Over Studies; D059305:Diet, High-Fat / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D005503:Food Additives / Q000008:administration & dosage / Q000494:pharmacology; D005936:Glucans / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism; D019518:Postprandial Period / Q000187:drug effects; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D005503:Food Additives; D005936:Glucans; D014280:Triglycerides; C033375:polydextrose