title: Effects of Schisandra chinensis Turcz. fruit on contact dermatitis induced by dinitrofluorobenzene in mice.
abstract: Schisandra chinensis Turcz. fruit is widely used to treat skin diseases. The aim of this study was to determine the anti-inflammatory effects of the methanol extract of S. chinensis (MESC) on 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) in mice. The effects of MESC on ear thickness and weight, histopathological changes, immune cell filtration and cytokine production were investigated in DNFB-induced CD mice. Topical application of MESC effectively inhibited ear swelling (30 or 300 μg on the left ear, P<0.001; 30 μg on the right ear, P<0.001). MESC also inhibited hyperplasia, spongiosis (100 μg/ear, P<0.05 and 300 μg/ear, P<0.001, respectively) and immune cell infiltration (100 μg/ear, P<0.05; 300 μg/ear, P<0.001) induced by DNFB. In addition, MESC suppressed increases in tumor necrosis factor (TNF)-α levels (100 or 300 μg/ear, P<0.05), interferon (INF)-γ (30 μg/ear, P<0.05; 100 μg/ear, P<0.01; 300 μg/ear, P<0.001), interleukin (IL)-6 (300 μg/ear, P<0.05) and monocyte chemoattractant protein (MCP)-1 (30 μg/ear, P<0.05; 100 μg/ear, P<0.01; 300 μg/ear, P<0.001). These results suggest that the anti-inflammatory effects of MESC are mediated by the reduced production of TNF-α, IFN-γ, IL-6 and MCP-1, and that MESC has potential use for the treatment of inflammatory skin diseases.
authors.affiliation: Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Gyeongsangnam-do 626‑870, Republic of Korea.
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Division of Pharmacology, Pusan National University School of Korean Medicine, Yangsan, Gyeongsangnam-do 626‑870, Republic of Korea.
authors.forename: Suzy
authors.initials: S
authors.lastname: Jo
authors.affiliation: Division of Pharmacology, Pusan National University School of Korean Medicine, Yangsan, Gyeongsangnam-do 626‑870, Republic of Korea.
authors.forename: Jeonghyun
authors.initials: J
authors.lastname: Ryu
authors.affiliation: Division of Applied Medicine, Pusan National University School of Korean Medicine, Yangsan, Gyeongsangnam-do 626‑870, Republic of Korea.
authors.forename: Han-Sol
authors.initials: HS
authors.lastname: Jeong
authors.affiliation: Department of Herbology, Wonkwang University College of Medicine, Iksan, North Jeolla 570‑749, Republic of Korea.
authors.forename: Guemsan
authors.initials: G
authors.lastname: Lee
authors.affiliation: Department of Oral Pathology, Pusan National University School of Dentistry, Yangsan, Gyeongsangnam-do 626‑870, Republic of Korea.
authors.forename: Mi Heon
authors.initials: MH
authors.lastname: Ryu
authors.affiliation: Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Gyeongsangnam-do 626‑870, Republic of Korea.
authors.forename: Myeong Ho
authors.initials: MH
authors.lastname: Jung
authors.affiliation: Division of Pharmacology, Pusan National University School of Korean Medicine, Yangsan, Gyeongsangnam-do 626‑870, Republic of Korea.
authors.forename: Hyungwoo
authors.initials: H
authors.lastname: Kim
authors.affiliation: Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Gyeongsangnam-do 626‑870, Republic of Korea.
authors.forename: Byung Joo
authors.initials: BJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use*; D018932:Chemokine CCL2 / Q000032:analysis / Q000276:immunology; D003877:Dermatitis, Contact / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D004139:Dinitrofluorobenzene; D004423:Ear / Q000473:pathology; D005638:Fruit / Q000737:chemistry; D006965:Hyperplasia / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000517:prevention & control; D007371:Interferon-gamma / Q000032:analysis / Q000276:immunology; D015850:Interleukin-6 / Q000032:analysis / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D032141:Schisandra / Q000737:chemistry*; D012867:Skin / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; C491768:Ccl2 protein, mouse; D018932:Chemokine CCL2; D015850:Interleukin-6; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D004139:Dinitrofluorobenzene