title: Microwave-assisted efficient conjugation of nanodiamond and paclitaxel.
abstract: Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond.
authors.affiliation: Department of Chemistry, National Dong Hwa University, Soufeng, Hualien 974, Taiwan.
authors.forename: Yi-Han
authors.initials: YH
authors.lastname: Hsieh
authors.affiliation: Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30068, Taiwan.
authors.forename: Kuang-Kai
authors.initials: KK
authors.lastname: Liu
authors.affiliation: Department of Chemistry, National Dong Hwa University, Soufeng, Hualien 974, Taiwan.
authors.forename: Rohidas S
authors.initials: RS
authors.lastname: Sulake
authors.affiliation: Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30068, Taiwan. Electronic address: jichao@faculty.nctu.edu.tw.
authors.forename: Jui-I
authors.initials: JI
authors.lastname: Chao
authors.affiliation: Department of Chemistry, National Dong Hwa University, Soufeng, Hualien 974, Taiwan. Electronic address: chinpiao@mail.ndhu.edu.tw.
authors.forename: Chinpiao
authors.initials: C
authors.lastname: Chen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D018130:Diamond; D008872:Microwaves; D049329:Nanostructures; D017239:Paclitaxel / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D018130:Diamond; D017239:Paclitaxel
keywords: Deaggregation; Lung cancer; Microwave irradiating; Nanodiamond; Paclitaxel