title: [Incorporation of TV regularization in deconvolution for partial volume correction in PET imaging].
abstract: We propose a method using total variation (TV) regularization in deconvolution for partial volume correction in PET imaging. In the degraded image model, we used TV regularization procedure in Van Cittert (VC) and Richardson-Lucy (RL) deconvolution algorithms. These methods were tested in simulated NCAT images and images of NEMA NU4-2008 IQ phantom and tumor-bearing mouse scanned by Simens Invoen microPET. The simulated experiment and tumor-bearing mouse experiment showed that the algorithms using TV regularization provided superior qualitative and quantitative appearance compared with traditional VC and RL algorithms. When the mean intensity of the tumor increased by (10±1.8)%, the SD increase percentage was decreased from 49.98% to 14.26% and from 42.76% to 4.70%, suggesting the efficiency of the proposed algorithms for reducing PVEs in PET.
authors.affiliation: School of Biomedical Engineering1, Department of PET Center, Nanfang Hospital2, Southern Medical University, Guangzhou 510515, China. E-mail: 347828770@qq.com.
authors.forename: De-Bin
authors.initials: DB
authors.lastname: Hu
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Lu
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Gao
authors.forename: Hou-Jin
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Yan-Jiang
authors.initials: YJ
authors.lastname: Han
authors.forename: Cheng-Wei
authors.initials: CW
authors.lastname: Gu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Ma
mesh_terms: D000465:Algorithms; D000818:Animals; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D051379:Mice; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography