title: Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958.
abstract: Two new hydroxycitric acid lactone derivatives named cinatrins D (1) and E (2), and a new γ-lactam, virgaricin B (3), along with a known similar compound, virgaricin (4), were isolated from a fermentation broth of the fungus Virgaria boninensis FKI-4958. The absolute stereo structures of the new compounds were established by a combination of spectroscopic methods and chemical modifications. All three newly discovered compounds possessed weak antibacterial activity.
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ishii
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nonaka
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sugawara
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Iwatsuki
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Rokuro
authors.initials: R
authors.lastname: Masuma
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Hirose
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sunazuka
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ōmura
authors.affiliation: Kitasato Institute for Life Sciences, Kitasato University, Minato-ku, Tokyo, Japan.|Graduate School of Infection Control Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Kazuro
authors.initials: K
authors.lastname: Shiomi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D002951:Citrates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D012988:Soil Microbiology
chemical_list: D000900:Anti-Bacterial Agents; D002951:Citrates; D007769:Lactams; D007783:Lactones; C000604594:cinatrin D; C000604595:cinatrin E; C000604596:virgaricin B