title: The MSL complex: juggling RNA-protein interactions for dosage compensation and beyond.
abstract: The Male Specific Lethal (MSL) complex provides an exquisite example of an epigenetic modulator that is involved in chromosome-wide as well as individual gene regulation in flies and mammals. In this review, we discuss the recent advances in biochemical and structural understanding of the MSL complex modules and how they function in X chromosome regulation in flies. Moreover, we describe possible conserved and dosage compensation-independent functions of the MSL complex with a particular focus on mammalian systems.
authors.affiliation: Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg im Breisgau, Germany.
authors.forename: Claudia Isabelle
authors.initials: CI
authors.lastname: Keller
authors.affiliation: Max Planck Institute of Immunobiology and Epigenetics, Stübeweg 51, 79108 Freiburg im Breisgau, Germany. Electronic address: akhtar@ie-freiburg.mpg.de.
authors.forename: Asifa
authors.initials: A
authors.lastname: Akhtar
mesh_terms: D000818:Animals; D004303:Dosage Compensation, Genetic; D004330:Drosophila; D044127:Epigenesis, Genetic; D005260:Female; D051548:Histone Acetyltransferases / Q000378:metabolism*; D006801:Humans; D008297:Male; D009687:Nuclear Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; D012313:RNA; D051548:Histone Acetyltransferases