title: [A case of gynandroblastoma in a 16-year old girl and review of literature].
abstract: An ovarian tumor (gynandroblastoma) in a 16-year old girl is reported. Clinical presentation include abdominal pain, signs of virilization and irregular menstrual cycles. Ultrasound scan examination reveals a cystic mass in a left ovary. The patient underwent a left ovariosalpingectomy. Grossly, a cystic mass (73 x 42 x 36 mm) with smooth outer surface and with many cysts was found in the left ovary. The intraoperative diagnosis was ovarian adenocarcinoma. Postoperative histological examination reveals that the tumor was presented by two patterns- nodules and nests of juvenile granulose cell pattern admixed with Sertoli-Leydig pattern as tubules and cyst and scanty Sertoli cells. On immunohistochemical staining the Granulosa cells were negative for cytokeratin AE1-AE3 and positive for Vimentin. The Sertoli cells were androgen receptor positive. A year after operation the patient had no abdominal pain, the menstrual cycles are regular but the virilization persist. Histogenesis and differential diagnosis are discussed.
authors.forename: P
authors.initials: P
authors.lastname: Marinova
authors.forename: R
authors.initials: R
authors.lastname: Ivanova
authors.forename: T
authors.initials: T
authors.lastname: Veselinova
authors.forename: B
authors.initials: B
authors.lastname: Jordanova
mesh_terms: D000293:Adolescent; D003560:Cysts / Q000473:pathology / Q000601:surgery; D005260:Female; D006107:Granulosa Cells / Q000473:pathology; D006801:Humans; D008297:Male; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D010053:Ovary / Q000473:pathology* / Q000601:surgery; D012708:Sertoli Cells / Q000473:pathology; D018312:Sex Cord-Gonadal Stromal Tumors / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin