title: Effective healing of endoscopic submucosal dissection-induced ulcers by a single week of proton pump inhibitor treatment: a retrospective study.
abstract: BACKGROUND
  Although artificial ulcers generally heal faster than Helicobacter pylori-related or nonsteroidal anti-inflammatory drug-related peptic ulcers, endoscopic submucosal dissection (ESD)-induced gastric ulcers are usually treated with a proton pump inhibitor (PPI) for 4-8 weeks. The effect of oral administration of a PPI for 1 week on ESD-induced gastric ulcers has not yet been evaluated. In the present study, we evaluated the efficacy of oral PPI for 1 week in patients with ESD-induced ulcers.
  
  
  METHODS
  We selected 45 patients who underwent ESD for gastric mucosal tumors between June 2005 and July 2006 at Toyama University Hospital, and who met our inclusion criteria. All patients received omeprazole intravenously for 2 days after ESD and then orally for 1 week to prevent bleeding. Twenty two patients received no further omeprazole therapy (1-week group) and the rest received omeprazole orally for 7 more weeks (8-week group). Follow-up endoscopy was performed at 1 day, 4 weeks, and 8 weeks after ESD. We compared the ulcer healing rates between both groups.
  
  
  RESULTS
  There were no significant differences between the groups in the ulcer-healing rate, because ulcers healed in 22 (96%) and 20 (91%) patients from the 8-week and 1-week groups, respectively.
  
  
  CONCLUSIONS
  In our study, oral administration of omeprazole for 1 week was sufficient to achieve healing of ESD-induced artificial gastric ulcers. A larger prospective trial will be required to confirm these findings.
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. shin-ya@nsknet.or.jp.|Department of Medical Oncology, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. shin-ya@nsknet.or.jp.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kajiura
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. ayhosoka@med.u-toyama.ac.jp.
authors.forename: Ayumu
authors.initials: A
authors.lastname: Hosokawa
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. uakira@med.u-toyama.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Ueda
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. m164-tym@umin.net.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mihara
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. takayuki@med.u-toyama.ac.jp.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ando
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. haruka52@med.u-toyama.ac.jp.
authors.forename: Haruka
authors.initials: H
authors.lastname: Fujinami
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. junnishi@med.u-toyama.ac.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Nishikawa
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. kogawa@fuga.ocn.ne.jp.
authors.forename: Kohei
authors.initials: K
authors.lastname: Ogawa
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. minemura@med.u-toyama.ac.jp.
authors.forename: Masami
authors.initials: M
authors.lastname: Minemura
authors.affiliation: Department of Gastroenterology and Hematology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama-ken, 930-0194, Japan. tsugi@med.u-toyama.ac.jp.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000236:Adenoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery; D005773:Gastroscopy / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D009853:Omeprazole