title: Exploring the genetic signature of body size in Yucatan miniature pig.
abstract: Since being domesticated about 10,000-12,000 years ago, domestic pigs (Sus scrofa domesticus) have been selected for traits of economic importance, in particular large body size. However, Yucatan miniature pigs have been selected for small body size to withstand high temperature environment and for laboratory use. This renders the Yucatan miniature pig a valuable model for understanding the evolution of body size. We investigate the genetic signature for selection of body size in the Yucatan miniature pig. Phylogenetic distance of Yucatan miniature pig was compared to other large swine breeds (Yorkshire, Landrace, Duroc and wild boar). By estimating the XP-EHH statistic using re-sequencing data derived from 70 pigs, we were able to unravel the signatures of selection of body size. We found that both selections at the level of organism, and at the cellular level have occurred. Selection at the higher levels include feed intake, regulation of body weight and increase in mass while selection at the molecular level includes cell cycle and cell proliferation. Positively selected genes probed by XP-EHH may provide insight into the docile character and innate immunity as well as body size of Yucatan miniature pig.
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
authors.forename: Hyeongmin
authors.initials: H
authors.lastname: Kim
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong, 456-749, Republic of Korea.
authors.forename: Ki Duk
authors.initials: KD
authors.lastname: Song
authors.affiliation: CHO & KIM Genomics, Seoul National University Research Park, Seoul, 151-919, Republic of Korea.
authors.forename: Hyeon Jeong
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
authors.forename: WonCheoul
authors.initials: W
authors.lastname: Park
authors.affiliation: Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, 151-742, Republic of Korea.
authors.forename: Jaemin
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
authors.forename: Taeheon
authors.initials: T
authors.lastname: Lee
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Shin
authors.affiliation: Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, 151-742, Republic of Korea.
authors.forename: Woori
authors.initials: W
authors.lastname: Kwak
authors.affiliation: Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, 151-742, Republic of Korea.
authors.forename: Young-jun
authors.initials: YJ
authors.lastname: Kwon
authors.affiliation: CHO & KIM Genomics, Seoul National University Research Park, Seoul, 151-919, Republic of Korea.
authors.forename: Samsun
authors.initials: S
authors.lastname: Sung
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
authors.forename: Sunjin
authors.initials: S
authors.lastname: Moon
authors.affiliation: National Institute of Animal Science, RDA, Suwon, 441-706, Republic of Korea.
authors.forename: Kyung-Tai
authors.initials: KT
authors.lastname: Lee
authors.affiliation: Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-806, Republic of Korea.
authors.forename: Namshin
authors.initials: N
authors.lastname: Kim
authors.affiliation: Swine Science Division, National Institute of Animal Science, RDA, Cheonan, 331-801, Republic of Korea.
authors.forename: Joon Ki
authors.initials: JK
authors.lastname: Hong
authors.affiliation: Animal Research Division, Seoul Zoo, Seoul, 427-702, Republic of Korea.
authors.forename: Kyung Yeon
authors.initials: KY
authors.lastname: Eo
authors.affiliation: Department of Animal Science and Technology, College of Life Science and Natural Resources, Sunchon National University, Suncheon, 540-950, Republic of Korea.
authors.forename: Kang Seok
authors.initials: KS
authors.lastname: Seo
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
authors.forename: Girak
authors.initials: G
authors.lastname: Kim
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
authors.forename: Sungmoo
authors.initials: S
authors.lastname: Park
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea.
authors.forename: Cheol-Heui
authors.initials: CH
authors.lastname: Yun
authors.affiliation: Optipharm, Inc., 63, Osongsangmyeong 6-ro, Osong-eup, Chengwon-gun, Chungcheongbuk-do, 363-954, Republic of Korea.
authors.forename: Hyunil
authors.initials: H
authors.lastname: Kim
authors.affiliation: Optipharm, Inc., 63, Osongsangmyeong 6-ro, Osong-eup, Chengwon-gun, Chungcheongbuk-do, 363-954, Republic of Korea.
authors.forename: Kimyung
authors.initials: K
authors.lastname: Choi
authors.affiliation: Optipharm, Inc., 63, Osongsangmyeong 6-ro, Osong-eup, Chengwon-gun, Chungcheongbuk-do, 363-954, Republic of Korea.
authors.forename: Jiho
authors.initials: J
authors.lastname: Kim
authors.affiliation: Laboratory of Developmental Genetics, College of Medicine, Inha University, Incheon, 400-103, Republic of Korea.
authors.forename: Woon Kyu
authors.initials: WK
authors.lastname: Lee
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong, 456-749, Republic of Korea.
authors.forename: Duk-Kyung
authors.initials: DK
authors.lastname: Kim
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong, 456-749, Republic of Korea.
authors.forename: Jae-Don
authors.initials: JD
authors.lastname: Oh
authors.affiliation: Department of Animal Sciencs, Iowa State University, Ames, Iowa, 50011, United States of America.
authors.forename: Eui-Soo
authors.initials: ES
authors.lastname: Kim
authors.affiliation: CHO & KIM Genomics, Seoul National University Research Park, Seoul, 151-919, Republic of Korea.
authors.forename: Seoae
authors.initials: S
authors.lastname: Cho
authors.affiliation: Genomic Informatics Center, Hankyong National University, Anseong, 456-749, Republic of Korea.
authors.forename: Hak-Kyo
authors.initials: HK
authors.lastname: Lee
authors.affiliation: National Institute of Animal Science, RDA, Suwon, 441-706, Republic of Korea.
authors.forename: Tae-Hun
authors.initials: TH
authors.lastname: Kim
authors.affiliation: Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Republic of Korea; CHO & KIM Genomics, Seoul National University Research Park, Seoul, 151-919, Republic of Korea.
authors.forename: Heebal
authors.initials: H
authors.lastname: Kim
mesh_terms: D000818:Animals; D005075:Biological Evolution; D049628:Body Size / Q000235:genetics*; D016678:Genome; D059014:High-Throughput Nucleotide Sequencing; D007113:Immunity, Innate; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D025341:Principal Component Analysis; D017422:Sequence Analysis, DNA; D013552:Swine; D013556:Swine, Miniature / Q000033:anatomy & histology* / Q000145:classification / Q000235:genetics* / Q000378:metabolism