title: Heart rate variability and arterial oxygen saturation response during extreme normobaric hypoxia.
abstract: The primary purpose of this study was to assess the response of autonomic cardiac activity and changes in the arterial oxygen saturation (SpO2) during normobaric hypoxia and subsequent recovery. Heart rate variability (HRV) and SpO2 were monitored in a supine position during hypoxia (FiO2=9.6%) for 10min, and normoxic recovery in 29 subjects. Spectral analysis of HRV quantified the autonomic cardiac activity by means of low frequency (LF) (0.05-0.15Hz) and high frequency (HF) (0.15-0.50Hz) power transformed by natural logarithm (Ln). Based on the SpO2 response to hypoxia, the subjects were divided into Resistant (RG, SpO2=80.8±7.0%) or Sensitive (SG, SpO2=67.2±2.9%) group. The SpO2 and vagal activity (LnHF) significantly decreased during hypoxia in both groups. A withdrawal in vagal activity was significantly greater in SG compared to RG. Moreover, only in SG, a relative increase in sympathetic modulation (Ln LF/HF) during hypoxia occurred. Correlations (r=-0.461, and r=0.595, both P<0.05) between ΔSpO2 (delta) and ΔLn LF/HF, and ΔLnHF were found. Based on results, it seems that SpO2 level could be an important factor that influences the autonomic cardiac response in hypoxia.
authors.affiliation: Department of Natural Sciences in Kinanthropology, Faculty of Physical Culture, Palacký University Olomouc, Olomouc, Czech Republic.
authors.forename: Michal
authors.initials: M
authors.lastname: Botek
authors.affiliation: Department of Natural Sciences in Kinanthropology, Faculty of Physical Culture, Palacký University Olomouc, Olomouc, Czech Republic. Electronic address: jakub.krejci@upol.cz.
authors.forename: Jakub
authors.initials: J
authors.lastname: Krejčí
authors.affiliation: Exercise Physiology Research Group, Department of Kinesiology, KU Leuven, Leuven, Belgium.
authors.forename: Stefan
authors.initials: S
authors.lastname: De Smet
authors.affiliation: Department of Natural Sciences in Kinanthropology, Faculty of Physical Culture, Palacký University Olomouc, Olomouc, Czech Republic.
authors.forename: Aleš
authors.initials: A
authors.lastname: Gába
authors.affiliation: Discipline of Sport and Exercise Science, Faculty of Health, UC-Research Institute for Sport and Exercise, University of Canberra, ACT, Australia; Discipline of Biokinetics, Exercise and Leisure Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: McKune
mesh_terms: D000328:Adult; D001158:Arteries / Q000378:metabolism*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000097:blood*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014630:Vagus Nerve / Q000503:physiopathology
chemical_list: D010100:Oxygen
keywords: Autonomic cardiac regulation; Desaturation; Simulated altitude; Sympathovagal balance; Vagal activity