title: Dietary L-arginine supplementation protects weanling pigs from deoxynivalenol-induced toxicity.
abstract: This study was conducted to determine the positive effects of dietary supplementation with L-arginine (Arg) on piglets fed a deoxynivalenol (DON)-contaminated diet. A total of eighteen, 28-day-old healthy weanling pigs were randomly assigned into one of three groups: uncontaminated basal diet (control group), 6 mg/kg DON-contaminated diet (DON group) and 6 mg/kg DON + 1% L-arginine (DON + ARG group). After 21 days of Arg supplementation, piglets in the DON and DON + ARG groups were challenged by feeding 6 mg/kg DON-contaminated diet for seven days. The results showed that DON resulted in damage to piglets. However, clinical parameters, including jejunal morphology, amino acid concentrations in the serum, jejunum and ileum, were improved by Arg (p < 0.05). Furthermore, the mRNA levels for sodium-glucose transporter-1 (SGLT-1), glucose transporter type-2 (GLUT-2) and y(+)L-type amino acid transporter-1 (y(+)LAT-1) were downregulated in the DON group, but the values were increased in the DON + ARG group (p < 0.05). Collectively, these results indicate that dietary supplementation with Arg exerts a protective role in pigs fed DON-contaminated diets.
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China. adonis5@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China. liaopeng@isa.ac.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Liao
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China. hlq285687180@126.com.
authors.forename: Liuqin
authors.initials: L
authors.lastname: He
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China. zemengfeng2006@163.com.
authors.forename: Zemeng
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China. renwenkai19@126.com.
authors.forename: Wenkai
authors.initials: W
authors.lastname: Ren
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China. yinjie2014@126.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Yin
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China. djielin119@163.com.
authors.forename: Jielin
authors.initials: J
authors.lastname: Duan
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China. tjli@isa.ac.cn.
authors.forename: Tiejun
authors.initials: T
authors.lastname: Li
authors.affiliation: Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China. yinyulong@isa.ac.cn.
authors.forename: Yulong
authors.initials: Y
authors.lastname: Yin
mesh_terms: D000596:Amino Acids / Q000097:blood / Q000378:metabolism; D000821:Animal Feed / Q000382:microbiology; D000818:Animals; D000831:Animals, Newborn; D001120:Arginine / Q000494:pharmacology*; D019587:Dietary Supplements; D005260:Female; D005506:Food Contamination; D005670:Fusarium; D051273:Glucose Transporter Type 2 / Q000235:genetics; D007082:Ileum / Q000378:metabolism; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D027283:Large Neutral Amino Acid-Transporter 1 / Q000235:genetics; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051269:Sodium-Glucose Transporter 1 / Q000235:genetics; D013552:Swine; D014255:Trichothecenes / Q000633:toxicity*; D003313:Zea mays / Q000382:microbiology
chemical_list: D000596:Amino Acids; D051273:Glucose Transporter Type 2; D027283:Large Neutral Amino Acid-Transporter 1; D012333:RNA, Messenger; D051269:Sodium-Glucose Transporter 1; D014255:Trichothecenes; D001120:Arginine; C007262:deoxynivalenol