title: Natural evolution of broadly neutralizing antibodies.
abstract: Wu et al. couple next-generation sequencing with structural analysis to illuminate the key processes that enable the natural evolution and selection of broadly neutralizing antibodies to HIV-1, providing a potential roadmap for the development of HIV-1 vaccine strategies to accelerate the induction of protective antibodies.
authors.affiliation: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02138, USA.
authors.forename: Galit
authors.initials: G
authors.lastname: Alter
authors.affiliation: Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02138, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Electronic address: dbarouch@bidmc.harvard.edu.
authors.forename: Dan H
authors.initials: DH
authors.lastname: Barouch
mesh_terms: D057134:Antibodies, Neutralizing / Q000235:genetics*; D001402:B-Lymphocytes / Q000276:immunology*; D019143:Evolution, Molecular; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans
chemical_list: D057134:Antibodies, Neutralizing