title: Influence of Exercise on Inflammation in Cancer: Direct Effect or Innocent Bystander?
abstract: We propose the hypothesis that the benefits of exercise on inflammation in cancer are a result of a direct effect on inflammatory cytokines, including interleukin-6, tumor necrosis factor-α, and monocyte chemoattractant protein 1, that are critical for cancer growth as well as a bystander effect of the established relationship between exercise and cancer.
authors.affiliation: Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, SC.
authors.forename: E Angela
authors.initials: EA
authors.lastname: Murphy
authors.forename: Reilly T
authors.initials: RT
authors.lastname: Enos
authors.forename: Kandy T
authors.initials: KT
authors.lastname: Velázquez
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000503:physiopathology; D018932:Chemokine CCL2 / Q000378:metabolism; D003110:Colonic Neoplasms / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D015850:Interleukin-6 / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018932:Chemokine CCL2; D016207:Cytokines; C508600:IL6 protein, human; D015850:Interleukin-6; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha