title: Periorbital Necrotizing Fasciitis Secondary to Candida parapsilosis and Streptococcus pyogenes.
abstract: Necrotizing fasciitis is most often caused by either polymicrobial bacterial infections or by Gram-positive organisms, such as Streptococcus or Staphylococcus; however, rare cases of fungal necrotizing fasciitis have been reported. Candida parapsilosis is an emerging fungal pathogen. This fungus grows in either a yeast or pseudohyphal form. C. parapsilosis has been reported to cause keratitis, intraocular infection, and seeding of frontalis slings. C. parapsilosis is a commensal of human skin and can be acquired by nosocomial spread. Necrotizing fasciitis due to Candida has rarely been reported, but to date C. parapsilosis has not been identified as the causative organism in necrotizing fasciitis. This is the first documented case of human periocular soft tissue infection by C. parapsilosis, and also the first report providing evidence of mycotic infection in a necrotizing fasciitis concurrently infected by Streptococcus pyogenes.
authors.affiliation: Vanderbilt Eye Institute, Vanderbilt University School of Medicine, Nashville, Tennessee, U.S.A.
authors.forename: Matthew
authors.initials: M
authors.lastname: Zhang
authors.forename: James
authors.initials: J
authors.lastname: Chelnis
authors.forename: Louise A
authors.initials: LA
authors.lastname: Mawn
mesh_terms: D002175:Candida / Q000302:isolation & purification*; D002179:Candidiasis, Cutaneous / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D003428:Cross Infection; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D019115:Fasciitis, Necrotizing / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009916:Orbital Diseases / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D013290:Streptococcal Infections / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000302:isolation & purification*; D014057:Tomography, X-Ray Computed