title: Short-Term Variation of the Fetal Heart Rate for Predicting Neonatal Acidosis in Preeclampsia.
abstract: BACKGROUND
  The aim of this study was to measure the performance of short-term variation (STV) in predicting the onset of neonatal acidosis in fetuses at risk due to maternal preeclampsia.
  
  
  METHODS
  This retrospective study examined data from a series of 159 women with singleton pregnancies, hospitalized for preeclampsia in a level 3 reference maternity hospital in northern France, with an STV measurement in the 24 h preceding cesarean delivery and a measurement of the newborn's arterial cord pH at birth. The main outcome was determined by a correlation between STV and neonatal pH.
  
  
  RESULTS
  The last computerized fetal heart rate analysis took place a mean of 7.9 ± 6.3 h before birth, and neonatal acidosis was diagnosed in 38 newborns (23.9%). Although STV and umbilical artery pH at birth were significantly correlated (x03C1; = 0.16, p < 0.05), the performance of STV in predicting neonatal acidosis was poor, with an area under the ROC curve of 0.63. The sensitivity reached only 50.0% and the specificity 71.9% at the best STV threshold for predicting acidosis.
  
  
  CONCLUSIONS
  The performance of STV for screening for neonatal acidosis is poor in women with preeclampsia. The divergent results between studies are probably due to the variable intervals between STV measurement and birth.
authors.affiliation: Px00F4;le Femme Mx00E8;re Nouveau-nx00E9;, Hx00F4;pital Jeanne de Flandre, Lille, France.
authors.forename: Eva Marie
authors.initials: EM
authors.lastname: Aernout
authors.forename: Patrick
authors.initials: P
authors.lastname: Devos
authors.forename: Philippe
authors.initials: P
authors.lastname: Deruelle
authors.forename: Véronique
authors.initials: V
authors.lastname: Houfflin-Debarge
authors.forename: Damien
authors.initials: D
authors.lastname: Subtil
mesh_terms: D000138:Acidosis / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D005312:Fetal Blood; D005865:Gestational Age; D006340:Heart Rate, Fetal / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D008297:Male; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D012189:Retrospective Studies; D012680:Sensitivity and Specificity