title: A case of transfusion independence in a patient with myelodysplastic syndrome using deferasirox, sustained for two years after stopping therapy.
abstract: Patients with myelodysplastic syndrome (mds) experience clinical complications related to progressive marrow failure and have an increased risk of developing acute myeloid leukemia. Frequent red blood cell transfusion can lead to clinical iron overload and is associated with decreased survival in mds patients. Iron chelation therapy reduces markers of iron overload and prevents end-organ damage. Here, we present the case of a patient with low-risk mds with transfusional iron overload. He was treated for 2 years with an oral iron chelator, deferasirox, and after 12 months of treatment, he experienced a hemoglobin increase of more than 50 g/L, becoming transfusion-independent. He has remained transfusion-independent, with a normal hemoglobin level, for more than 2 years since stopping chelation therapy. Hematologic and erythroid responses have previously been reported in mds patients treated with iron chelation. The durability of our patient's response suggests that iron chelation might alter the natural history of mds in some patients.
authors.affiliation: Department of Medicine, Division of Hematology, London Health Sciences Centre, University of Western Ontario, London, ON.
authors.forename: D
authors.initials: D
authors.lastname: Sanford
authors.affiliation: Department of Medicine, Division of Hematology, London Health Sciences Centre, University of Western Ontario, London, ON.
authors.forename: C C
authors.initials: CC
authors.lastname: Hsia
keywords: Myelodysplastic syndrome; iron chelation; iron overload