title: Role of nutritional factors at the early life stages in the pathogenesis and clinical course of type 1 diabetes.
abstract: Nutrition has been suggested as an important environmental factor other than viruses and chemicals in the pathogenesis of type 1 diabetes (T1D). Whereas various maternal dietary nutritional elements have been suggested and examined in T1D of both humans and experimental animals, the results largely remain controversial. In a series of studies using T1D model nonobese diabetic (NOD) mice, maternal dietary n-6/n-3 essential fatty acid ratio during pregnancy and lactation period, that is, early life stages of the offspring, has been shown to affect pathogenesis of insulitis and strongly prevent overt T1D of the offspring, which is consistent with its preventive effects on other allergic diseases.
authors.affiliation: Department of Health and Nutrition, The University of Shimane, Matsue, Shimane 690-0044, Japan ; Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kagohashi
authors.affiliation: Department of Developmental Biology, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan.
authors.forename: Hiroki
authors.identifier: 0000-0002-0331-3008
authors.initials: H
authors.lastname: Otani
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001323:Autoantibodies / Q000737:chemistry; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D004032:Diet; D004195:Disease Models, Animal; D004777:Environment; D005227:Fatty Acids / Q000737:chemistry; D005228:Fatty Acids, Essential / Q000737:chemistry; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D039382:Maternal Nutritional Physiological Phenomena; D051379:Mice; D016688:Mice, Inbred NOD; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
chemical_list: D001323:Autoantibodies; D005227:Fatty Acids; D005228:Fatty Acids, Essential; D007328:Insulin