title: Postoperative recurrence of desmoid tumors: clinical and pathological perspectives.
abstract: BACKGROUND
  The clinical features and the pathological changes of desmoid tumors were studied to point out the key factors affecting the recurrence.
  
  
  METHODS
  The clinical data and specimens of 56 patients who underwent desmoid tumor resection from 2003 to 2008 were reviewed. Possible clinical factors related to the postoperative recurrence were analyzed statistically. The specimens round the lesions were studied histopathologically.
  
  
  RESULTS
  The overall recurrence rate was 39.3%. The postoperative recurrence rate of the patients with negative surgical margins and no tumor invasion of the major vessels and nerves was low (P < 0.05). However, the desmoid tumors could destroy the cortical bone and invade the medullary cavity.
  
  
  CONCLUSIONS
  Desmoid tumors were pathologically benign, which could extensively invade tissues around the lesions. The invasion of major vessels and nerves and quality of surgical margins are the key factors for the high postoperative recurrence rate.
authors.affiliation: Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, P.R. China. yfwangpeking@gmail.com.
authors.forename: Yi-fei
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, P.R. China. guowpeking@gmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.affiliation: Department of Pathology, Peking University People's Hospital, Beijing, 100044, P.R. China. kksunpeking@gmail.com.
authors.forename: Kun-kun
authors.initials: KK
authors.lastname: Sun
authors.affiliation: Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, P.R. China. rlyangpeking@gmail.com.
authors.forename: Rong-li
authors.initials: RL
authors.lastname: Yang
authors.affiliation: Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, P.R. China. xdtangpeking@gmail.com.
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Tang
authors.affiliation: Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, P.R. China. tjipeking@gmail.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Ji
authors.affiliation: Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, 100044, P.R. China. stangpeking@gmail.com.
authors.forename: Shun
authors.initials: S
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D018222:Desmoid Tumors / Q000150:complications* / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000453:epidemiology*; D009367:Neoplasm Staging; D011183:Postoperative Complications; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult