title: A decline of LAMP- 2 predicts ursodeoxycholic acid response in primary biliary cirrhosis.
abstract: Biochemical response to ursodeoxycholic acid (UDCA) in patients with primary biliary cirrhosis (PBC) is variable. We have previously reported that augmented expression of lysosome-associated membrane protein 2 (LAMP-2) was correlated with the severity of PBC. This study aimed to determine whether serum LAMP-2 could serve as a predictor of biochemical response to UDCA. The efficiency of serum LAMP-2 to predict biochemical response was assessed after 1 year of UDCA treatment in PBC patients by a retrospective analysis. We found that the basal serum LAMP-2 level was increased in PBC, especially in patients with stage III-IV (p = 0.010) or TBIL > 1 mg/dL (p = 0.014). Baseline serum LAMP-2 was higher in non-responders than that in responders, but the difference was statistically insignificant. However, after UDCA treatment, serum LAMP-2 level decreased prominently in the first 3 months, which was more obvious in responders. Further studies showed that the 35% decline of LAMP-2 after treatment for 3 months could be stated as an indicator of UDCA response with the sensitivity of 62.9% and specificity of 75.0% by Paris criteria. Meanwhile the specificity and sensitivity were identified as 63.5% and 64.1% by Barcelona criteria. Together, a decline in LAMP-2 might help to predict the response to UDCA.
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Guan-ya
authors.initials: GY
authors.lastname: Guo
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Jing-bo
authors.initials: JB
authors.lastname: Wang
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Xin-min
authors.initials: XM
authors.lastname: Zhou
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Zhe-yi
authors.initials: ZY
authors.lastname: Han
authors.affiliation: Department of Digestive Disease, 153 Central Hospital of PLA, Zhengzhou 450042, Henan Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Jing-wen
authors.initials: JW
authors.lastname: Zhang
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Cai
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Ren
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Chen
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Yong-quan
authors.initials: YQ
authors.lastname: Shi
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: Division of Hepatology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xian, 710032, Shaanxi Province, China.
authors.forename: Dai-ming
authors.initials: DM
authors.lastname: Fan
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D003710:Demography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D052119:Lysosomal-Associated Membrane Protein 2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: C497811:LAMP2 protein, human; D052119:Lysosomal-Associated Membrane Protein 2; D014580:Ursodeoxycholic Acid