title: Maternal and neonatal outcomes in labor and at delivery when long QT syndrome is present.
abstract: OBJECTIVE
  Women during labor may be susceptible to torsades de pointes (TdP), which may cause the fetal condition to deteriorate. The aim of the present investigation was to analyze maternal and fetal outcomes during labor when long QT syndrome (LQTS) was present.
  
  
  METHODS
  We examined the maternal and neonatal outcomes of 25 pregnancies (18 women) with LQT between 1995 and 2012 at the Department of Perinatology, National Cardiovascular Center, Japan. Maternal and neonatal outcomes including cardiovascular events, cardiovascular events within a week after delivery, caesarean delivery rate, still births, preterm births, and non-reassuring fetal heart rate pattern (NRFHR) during labor were investigated.
  
  
  RESULTS
  All the mothers survived, and no cardiovascular events occurred in labor or postpartum due to LQTS in either vaginal delivery or caesarean delivery. A total of 23 women (92%) had used beta blockers in this study. Caesarean delivery was performed due to NRFHR during labor in 5 pregnancies (20%).
  
  
  CONCLUSIONS
  Delivery when LQTS is present has a low likelihood of cardiovascular events, but pregnancy with LQTS had a higher caesarean delivery rate due to NRFHR in labor. Most women used beta blockers in this study, and it is possible that beta blocker use prevents cardiovascular events during labor. NRFHR during labor may be related with inherited LQT through the mother.
authors.affiliation: a Department of Perinatology , National Cerebral and Cardiovascular Center , Suita , Osaka , Japan and.|b Department of Obstetrics and Gynecology , Mie University Faculty Medicine , Tsu , Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: a Department of Perinatology , National Cerebral and Cardiovascular Center , Suita , Osaka , Japan and.
authors.forename: Shinji
authors.initials: S
authors.lastname: Katsuragi
authors.affiliation: a Department of Perinatology , National Cerebral and Cardiovascular Center , Suita , Osaka , Japan and.
authors.forename: Kayo
authors.initials: K
authors.lastname: Tanaka
authors.affiliation: a Department of Perinatology , National Cerebral and Cardiovascular Center , Suita , Osaka , Japan and.
authors.forename: Masami
authors.initials: M
authors.lastname: Sawada
authors.affiliation: a Department of Perinatology , National Cerebral and Cardiovascular Center , Suita , Osaka , Japan and.
authors.forename: Naoko
authors.initials: N
authors.lastname: Iwanaga
authors.affiliation: a Department of Perinatology , National Cerebral and Cardiovascular Center , Suita , Osaka , Japan and.
authors.forename: Jun
authors.initials: J
authors.lastname: Yoshimatsu
authors.affiliation: b Department of Obstetrics and Gynecology , Mie University Faculty Medicine , Tsu , Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D036861:Delivery, Obstetric / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D005316:Fetal Distress / Q000453:epidemiology; D006340:Heart Rate, Fetal; D006801:Humans; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D007743:Labor, Obstetric / Q000187:drug effects / Q000502:physiology; D008133:Long QT Syndrome / Q000453:epidemiology* / Q000628:therapy*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000319:Adrenergic beta-Antagonists
keywords: Delivery mode; long QT syndrome; pregnancy