title: Biological Activities of QIAPI 1 as a Melanin Precursor and Its Therapeutic Effects in Wistar Rats Exposed to Arsenic Poisoning.
abstract: The chemical process initiated by QIAPI 1 has been deemed to be the most important biological reaction associated with human photosynthesis, and possibly neuroprotective effects under various inflammatory events. However, the detailed biological activities of QIAPI 1 as a melanin precursor are still unknown. In the present work, cytotoxicity test was done by MTT assay to determine cell viability of various cell lines (WI-38, A549, HS 683) like proliferation tests and its effect on cytokine production. Arsenic poisoning is an often-unrecognized cause of renal insufficiency. No prophylactic and/or therapeutic compounds have shown promising results against kidney diseases. The pathogenesis of Arsenic-induced nephropathy is not clear. Arsenic, as itself, does not degrade over time in the environment, and its accumulation may induce toxic effects. In this study, we also report the histological findings of the kidney in 3 groups of Wistar rats, a control group, a group exposed to arsenic in the water; and a group exposed to arsenic and treated with QIAPI 1 simultaneously. The findings of the current evidence indicates a potential therapeutic ability of QIAPI 1.
authors.forename: Arturo
authors.initials: A
authors.lastname: Solís-Herrera
authors.forename: Ghulam M
authors.initials: GM
authors.lastname: Ashraf
authors.forename: María
authors.initials: M
authors.lastname: del C A Esparza
authors.forename: Ruth I S
authors.initials: RI
authors.lastname: Arias
authors.forename: Sergei O
authors.initials: SO
authors.lastname: Bachurin
authors.forename: George E
authors.initials: GE
authors.lastname: Barreto
authors.affiliation: "GALLY" International Biomedical Research Consulting LLC, San Antonio, TX 78229, USA. aliev03@gmail.com.
authors.forename: Gjumrakch
authors.initials: G
authors.lastname: Aliev
mesh_terms: D000328:Adult; D000818:Animals; D020261:Arsenic Poisoning / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D002460:Cell Line; D016207:Cytokines / Q000096:biosynthesis; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008543:Melanins / Q000378:metabolism; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000627:therapeutic use*; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects; D055815:Young Adult
chemical_list: D016207:Cytokines; D008543:Melanins; D004366:Nonprescription Drugs