title: Neurochemical, structural and neurobehavioral evidence of neuronal protection by whey proteins in diabetic albino mice.
abstract: BACKGROUND
  Diabetes Mellitus (DM) is associated with pathological changes in the central nervous system (CNS) and alterations in oxidative stress. The aim of this study was to determine whether dietary supplement with whey protein (WP) could improve neurobehavior, oxidative stress and neuronal structure in the CNS.
  
  
  METHODS
  Animals were distributed in three groups, a control group (N), a diabetic mellitus group (DM) and a DM group orally supplemented with WP (WP).
  
  
  RESULTS
  The DM group of animals receiving WP had reduced blood glucose, significantly decreased free radical Diphenyl-picrylhydrazyl (DPPH) and lower lipid peroxidation in brain tissue. The WP group of animals showed improvement in balancing, coordination and fore-limb strength, oxidative stress and neuronal structure.
  
  
  CONCLUSIONS
  The results of this study show that dietary supplementation with WP reduced oxidative stress, protected CNS neurons and improved the neurobehavior of diabetic mice.
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. jajarem@ksu.edu.sa.
authors.forename: Jamaan
authors.initials: J
authors.lastname: Ajarem
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. aallam@ksu.edu.sa.|Department of Zoology, Faculty of Science, Beni-suef University, Beni-Suef, Egypt. aallam@ksu.edu.sa.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Allam
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. hossamebaid@yahoo.com.|Department of Zoology, Faculty of Science, Menia University, Minya, Egypt. hossamebaid@yahoo.com.
authors.forename: Hossam
authors.initials: H
authors.lastname: Ebaid
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. maodaa_28@yahoo.com.
authors.forename: Saleh N
authors.initials: SN
authors.lastname: Maodaa
authors.affiliation: Shaqra University Sajir College of Arts & Science, Shaqra, Saudi Arabia. sanadm555@gmail.com.
authors.forename: Sanad M
authors.initials: SM
authors.lastname: Al-Sobeai
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. rady_gad1983@yahoo.com.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Rady
authors.affiliation: Department of Food Science, College of Agriculture and Food Science, King Saud University, Riyadh, Saudi Arabia. ametwalli@ksu.edu.sa.|Department of Dairy, Faculty of Agriculture, El-Minia University, El-Minia, Egypt. ametwalli@ksu.edu.sa.
authors.forename: Ali
authors.initials: A
authors.lastname: Metwalli
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. naifaltoom@hotmail.com.
authors.forename: Naif G
authors.initials: NG
authors.lastname: Altoom
authors.affiliation: Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. kibrahim@ksu.edu.sa.
authors.forename: Khaled Elfakki
authors.initials: KE
authors.lastname: Ibrahim
authors.affiliation: Oregon Health & Science University, Portland, OR, USA. sabri@ohsu.edu.
authors.forename: Mohammad I
authors.initials: MI
authors.lastname: Sabri
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001713:Biphenyl Compounds / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry / Q000187:drug effects*; D002162:Camelus; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000523:psychology*; D018737:Hand Strength; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010851:Picrates / Q000378:metabolism; D000067816:Whey Proteins / Q000494:pharmacology*
chemical_list: D001713:Biphenyl Compounds; D001786:Blood Glucose; D018696:Neuroprotective Agents; D010851:Picrates; D000067816:Whey Proteins; C004931:1,1-diphenyl-2-picrylhydrazyl