title: A Review: The Pharmacology of Isoliquiritigenin.
abstract: Isoliquiritigenin (ISL) is one of the bioactive ingredients isolated from the roots of plants belonging to licorice, including Glycyrrhiza uralensis, Mongolian glycyrrhiza, Glycyrrhiza glabra, and so forth. Liquiritigenin is available in common foods and alternative medicine, and its derivative-ISL is applied into food additives and disease treatment like cancer therapy, antibiotic therapy, and so on. This review aims at providing a comprehensive summary of the pharmacological activities of ISL. The information published between 1972 and 2014 from a number of reliable sources including PubMed, ScienceDirect, Springer, and Wiley-Blackwell. The practical application of ISL on the various disease prevention and treatments may stem from its numerous pharmacological properties such as antiinflammatory, anti-microbial, anti-oxidative, anticancer activities, immunoregulatory, hepatoprotective, and cardioprotective effects. However, further studies are needed to verify the target-organ toxicity or side effects investigation.
authors.affiliation: School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong.|Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.|State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu, 610075, China.
authors.forename: Fu
authors.initials: F
authors.lastname: Peng
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.|State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu, 610075, China.
authors.forename: Qiaohui
authors.initials: Q
authors.lastname: Du
authors.affiliation: Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.|State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu, 610075, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong.
authors.forename: Neng
authors.initials: N
authors.lastname: Wang
authors.affiliation: School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong.|Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.
authors.forename: Hailin
authors.initials: H
authors.lastname: Tang
authors.affiliation: Department of Breast Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Xie
authors.affiliation: School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong.
authors.forename: Jiangang
authors.initials: J
authors.lastname: Shen
authors.affiliation: School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong.|Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.|State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu, 610075, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Chen
mesh_terms: D047188:Chalcones / Q000494:pharmacology*; D044950:Flavanones / Q000494:pharmacology; D029882:Glycyrrhiza uralensis / Q000737:chemistry; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
chemical_list: D047188:Chalcones; D044950:Flavanones; D010936:Plant Extracts; C040920:isoliquiritigenin; C083152:liquiritigenin
keywords: isoliquiritigenin; natural medicine; pharmacological properties