title: Alpha-melanocyte stimulating hormone inhibits monocytes adhesion to vascular endothelium.
abstract: Inflammation and its subsequent endothelial dysfunction have been reported to play a pivotal role in the initiation and progression of chronic vascular diseases. Inhibiting the attachment of monocytes to endothelium is a potential therapeutic strategy for vascular diseases treatment. α-Melanocyte stimulating hormone is generated from a precursor hormone called proopiomelanocortin by post-translational processing. However, whether α-melanocyte stimulating hormone plays a role in regulating endothelial inflammation is still unknown. In this study, the effects of α-melanocyte stimulating hormone on endothelial inflammation in human umbilical vein endothelial cell lines were investigated. And the result indicated that α-melanocyte stimulating hormone inhibits the expression of endothelial adhesion molecules, including vascular adhesion molecule-1 and E-selectin, thereby attenuating the adhesion of THP-1 cells to the surface of endothelial cells. Mechanistically, α-melanocyte stimulating hormone was found to inhibit NF-κB transcriptional activity. Finally, we found that the effect of α-melanocyte stimulating hormone on endothelial inflammation is dependent on its receptor melanocortin receptor 1.
authors.affiliation: Department of Cardiology, The First Bethune Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Cardiology, The First Bethune Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, The First Bethune Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Meng
authors.affiliation: Department of Cardiology, The First Bethune Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Cardiology, The First Bethune Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Na
authors.initials: N
authors.lastname: Lu
authors.affiliation: Department of Cardiology, The First Bethune Hospital of Jilin University, Changchun, 130021, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Fu
authors.affiliation: Department of Cardiology, The First Bethune Hospital of Jilin University, Changchun, 130021, China yangzheng325@yeah.net.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D002448:Cell Adhesion; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D019040:E-Selectin / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry; D007249:Inflammation; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D009000:Monocytes / Q000166:cytology / Q000187:drug effects*; D052002:NF-kappa B p50 Subunit / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism; D000521:alpha-MSH / Q000737:chemistry*
chemical_list: D016207:Cytokines; D019040:E-Selectin; D007166:Immunosuppressive Agents; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; C546936:SELE protein, human; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D000521:alpha-MSH
keywords: NF-κB; VCAM-1; endothelial inflammation; α-Melanocyte stimulating hormone