title: Practical Iron- and Cobalt-Catalyzed Cross-Coupling Reactions between N-Heterocyclic Halides and Aryl or Heteroaryl Magnesium Reagents.
abstract: The reaction scope of iron- and cobalt-catalyzed cross-coupling reactions in the presence of isoquinoline (quinoline) in the solvent mixture tBuOMe/THF has been further investigated. Various 2-halogenated pyridine, pyrimidine, and triazine derivatives were arylated under these mild conditions in excellent yields. The presence of isoquinoline allows us to perform Fe-catalyzed cross-coupling reactions between 6-chloroquinoline and aryl magnesium reagents. Furthermore, it was found that the use of 10% N,N-dimethylquinoline-8-amine increases the yields of some Co-catalyzed cross-coupling reactions with chloropyridines bearing electron-withdrawing substituents.
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich (Germany).
authors.forename: Olesya M
authors.initials: OM
authors.lastname: Kuzmina
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich (Germany).
authors.forename: Andreas K
authors.initials: AK
authors.lastname: Steib
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich (Germany).
authors.forename: Sarah
authors.initials: S
authors.lastname: Fernandez
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich (Germany).
authors.forename: Willy
authors.initials: W
authors.lastname: Boudot
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich (Germany).
authors.forename: John T
authors.initials: JT
authors.lastname: Markiewicz
authors.affiliation: Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 Munich (Germany). paul.knochel@cup.uni-muenchen.de.
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
keywords: Grignard reagents; N-heterocycles; cobalt; cross-coupling; iron