title: Progressive subacute Miller-Fisher syndrome successfully treated with plasmapheresis.
abstract: BACKGROUND
  Miller-Fisher Syndrome (MFS) is a rare acute polyneuropathy composed of the clinical triad of ataxia, areflexia and ophthalmoplegia, with a monophasic, self-limited course and spontaneous improvement.
  
  
  METHODS
  The authors present a 65-year-old man with Miller-Fisher syndrome consisting of bilateral ophthalmoplegia, trigeminal and facial nerve palsy, mild ataxia and peripheral neuropathy. The disease had a progressive, subacute course within 3 months. A high titer of anti-GQ1b antibodies was detected. As a result of plasmapheresis, complete recovery was achieved.
  
  
  CONCLUSIONS
  The presented case was atypical in its clinical course and treatment. It could support the theory of the continuity between MFS, Bickerstaff brainstem encephalitis (BBE), and Guillain-Barré syndrome (GBS).
authors.affiliation: Department of Neurology, Wrocław Medical University, Wrocław, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Ejma
authors.affiliation: Department of Neurology, Wrocław Medical University, Wrocław, Poland. Electronic address: marta.waliszewska@gmail.com.
authors.forename: Marta
authors.initials: M
authors.lastname: Waliszewska-Prosół
authors.affiliation: Department of Neurology, Wrocław Medical University, Wrocław, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Hofman
authors.affiliation: Department of Neurology, Wrocław Medical University, Wrocław, Poland.
authors.forename: Sławomir
authors.initials: S
authors.lastname: Budrewicz
authors.affiliation: Department of Neurology, Wrocław Medical University, Wrocław, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Podemski
authors.affiliation: Department of Neurology, Wrocław Medical University, Wrocław, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Bilińska
authors.affiliation: Department of Neurology, Wrocław Medical University, Wrocław, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Koszewicz
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000276:immunology / Q000302:isolation & purification; D005732:Gangliosides / Q000276:immunology; D006801:Humans; D008297:Male; D019846:Miller Fisher Syndrome / Q000628:therapy*; D010951:Plasma Exchange; D010956:Plasmapheresis / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; C039129:GQ1b ganglioside
keywords: Anti-GQ1b antibody; Miller-Fisher syndrome; Plasmapheresis