title: Medullary hemangioblastoma in a child with von Hippel-Lindau disease: vascular tumor perfusion depicted by arterial spin labeling and dynamic contrast-enhanced imaging.
abstract: Medullary hemangioblastoma is very rare in children. Based on small nodular enhancement with peritumoral edema and without dilated feeding arteries on conventional MRI, hemangioblastoma, pilocytic astrocytoma, oligodendroglioma, and ganglioglioma were included in the differential diagnosis of the medullary tumor. In this case report, the authors emphasize the diagnostic value of arterial spin labeling and dynamic contrast-enhanced MRI in demonstrating vascular tumor perfusion of hemangioblastoma in a 12-year-old boy who was later found to have von Hippel-Lindau disease.
authors.affiliation: Department of Radiology and Research Institute of Radiology, and.
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Goo
authors.affiliation: Department of Neurosurgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
authors.forename: Young-Shin
authors.initials: YS
authors.lastname: Ra
mesh_terms: D020295:Brain Stem Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002648:Child; D003287:Contrast Media; D018325:Hemangioblastoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology* / Q000601:surgery; D013113:Spin Labels; D006623:von Hippel-Lindau Disease / Q000150:complications*
chemical_list: D003287:Contrast Media; D013113:Spin Labels
keywords: ASL = arterial spin labeling; DCE = dynamic contrast-enhanced; DSC = dynamic susceptibility-weighted contrast-enhanced; EPI = echo-planar imaging; Kep = rate constant; Ktrans = transfer constant; VHL = von Hippel-Lindau; Ve = interstitial volume; Vp = blood plasma volume; arterial spin labeling; dynamic contrast-enhanced imaging; hemangioblastoma; medulla; oncology; perfusion MRI; rCBV = relative cerebral blood volume; rTBF = relative tumor blood flow; von Hippel-Lindau disease