title: [Correlation analysis of efficacy of yiqi chutan recipe in treating NSCLC and P4HB expression].
abstract: OBJECTIVE
  To study the predicting effect of proly 4-hydroxylase beta polypeptide (P4HB) in treating non-small cell lung cancer (NSCLC) patients by Yiqi Chutan Recipe (YCR).
  
  
  METHODS
  Totally 46 stage III and IV NSCLC patients were treated by YCR for 4 therapeutic courses. Effect was assessed by RECIST of solid tumor. P4HB expression was detected in the lung cancer tissue by immunohistochemical assay. Factors affecting disease control rates (DCR) of YCR were analyzed by Logistic regression analysis. The correlation between P4HB expression and the effect of YCR was analyzed.
  
  
  RESULTS
  The DCR of advanced NSCLC treated by YCR was 36.96% (17/46 cases). P4HB was high expressed in advanced lung cancer tissue (6/15 cases). Gender, initial treatment, and retreatment are independent factors for affecting DCR of treating lung cancer by YCR.
  
  
  CONCLUSIONS
  P4HB might be taken as a factor for predicting the effect of YCR in treating NSCLC.
authors.forename: Ling-ling
authors.initials: LL
authors.lastname: Sun
authors.forename: Li-zhu
authors.initials: LZ
authors.lastname: Lin
authors.forename: Jing-xu
authors.initials: JX
authors.lastname: Zhou
authors.forename: Zhuang-zhong
authors.initials: ZZ
authors.lastname: Chen
authors.forename: Wen-hui
authors.initials: WH
authors.lastname: Tao
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D008168:Lung; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D019704:Protein Disulfide-Isomerases / Q000378:metabolism*
chemical_list: D004365:Drugs, Chinese Herbal; D011393:Procollagen-Proline Dioxygenase; C526497:P4HB protein, human; D019704:Protein Disulfide-Isomerases