title: Perfusion MRI in the Evaluation of Suspected Glioblastoma Recurrence.
abstract: OBJECTIVE
  Treatment-related changes (TRC) often imitate tumor progression in glioblastomas. Increased regional cerebral blood volume (rCBV) can differentiate tumor progression from TRC after the standardized first-line radiochemotherapy, but information about diagnostic accuracy of rCBV for patients without any clinical selection criteria is limited. Therefore, we aimed to evaluate if rCBV can differentiate between TRC and tumor progression irrespective of preceding therapies and number of tumor progressions.
  
  
  METHODS
  We analyzed mean and maximum rCBV from the enhancing areas normalized to the contralateral white matter in 44 pretreated glioblastomas with MR-morphological tumor progression. The diagnosis (real progression vs. TRC) was determined by histopathology or by clinical/MRI-follow-up. We performed nonparametric tests, receiver operating characteristics (ROC), and Kaplan-Meier analysis.
  
  
  RESULTS
  Significant differences between tumor progression (N = 37) and TRC (N = 7) were found for rCBVmean (2.44 ± 1.05 vs. 1.69 ± .56, P < .03) and rCBVmax (3.40 ± 1.25 vs. 2.21 ± .62, P < .0007). A rCBVmax of 2.6 had 78% sensitivity and 86% specificity to detect tumor progression. Neither rCBVmean nor rCBVmax was predictive for the patient overall survival (OS). There were no statistically different rCBVmean and rCBVmax between the first and further tumor progressions.
  
  
  CONCLUSIONS
  The rCBVmax differentiates tumor progression from TRC in unselected recurrent glioblastomas, but it is not predictive for the OS.
authors.affiliation: Institute of Neuroradiology, Goethe-University Hospital Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany.
authors.forename: Stella
authors.initials: S
authors.lastname: Blasel
authors.affiliation: Institute of Neuroradiology, Goethe-University Hospital Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Zagorcic
authors.affiliation: Institute of Neuroradiology, Goethe-University Hospital Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany.
authors.forename: Alina
authors.initials: A
authors.lastname: Jurcoane
authors.affiliation: Dr. Senckenberg Institute of Neurooncology, Goethe-University Hospital Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Bähr
authors.affiliation: Institute of Neuroradiology, Goethe-University Hospital Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany.
authors.forename: Marlies
authors.initials: M
authors.lastname: Wagner
authors.affiliation: Edinger Institute, Institute of Neurology, Goethe-University Frankfurt, Heinrich Hoffmann Strasse 7, 60528, Frankfurt, Germany.
authors.forename: Patrick N
authors.initials: PN
authors.lastname: Harter
authors.affiliation: Institute of Neuroradiology, Goethe-University Hospital Frankfurt, Schleusenweg 2-16, 60528, Frankfurt, Germany.
authors.forename: Elke
authors.initials: E
authors.lastname: Hattingen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D011237:Predictive Value of Tests; D015996:Survival Rate
keywords: MR perfusion; glioblastoma; rCBV; treatment-related changes; tumor progression