title: The Effects of Hemodynamic Alterations on Lung Volumes in Fetuses with Tetralogy of Fallot: An MRI Study.
abstract: This study assessed whether the presence of tetralogy of Fallot (TOF) affects fetal lung development and whether these fetuses are at risk of pulmonary hypoplasia (PH). Furthermore, we investigated whether the degree of the concomitant pulmonary valve (PV) stenosis or a stenosis in the branch pulmonary arteries correlates with the fetal lung volume. Lung volumetry was performed in 16 fetuses with TOF who underwent MRI between gestational weeks 21 and 35 and in 22 controls. Fetal biometric data and the diameters of the PVs were evaluated by ultrasound. PV and branch pulmonary artery diameters were standardized (z-scores), and fetal lung volume/fetal body weight (FLV/FBW) ratios (ml/g) were calculated. The mean FLV/FBW ratio (0.031 ± 0.009 ml/g) in the TOF group was statistically significantly lower than in the control group (0.041 ± 0.009 ml/g; P = 0.003). None of the fetuses with TOF met the criterion for PH. FLV did not correlate with the degree of PV stenosis, but rather with the presence of a significant stenosis in at least one branch pulmonary artery. The presence of TOF moderately affects fetal lung growth, which is apparently not dependent on the degree of the PV stenosis. However, only an additional stenosis in at least one branch pulmonary artery was associated with a small FLV, but not with PH. Thus, reduced pulmonary blood flow may be offset by additional factors, such as the ability to establish a sufficient collateral system and to alter structural vascular size and, thus, pulmonary vascular resistance.
authors.affiliation: Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, AKH, Waehringer Guertel 18-20, 1090, Vienna, Austria, vanessa.berger-kulemann@meduniwien.ac.at.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Berger-Kulemann
authors.forename: Rudolf
authors.initials: R
authors.lastname: Berger
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Mlczoch
authors.forename: Daniel
authors.initials: D
authors.lastname: Sternal
authors.forename: Mariella
authors.initials: M
authors.lastname: Mailath-Pokorny
authors.forename: Nilouparak
authors.initials: N
authors.lastname: Hachemian
authors.forename: Daniela
authors.initials: D
authors.lastname: Prayer
authors.forename: Michael
authors.initials: M
authors.lastname: Weber
authors.forename: Ulrike
authors.initials: U
authors.lastname: Salzer-Muhar
mesh_terms: D005260:Female; D020567:Fetal Weight; D005333:Fetus / Q000002:abnormalities*; D005865:Gestational Age; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D011247:Pregnancy; D011651:Pulmonary Artery / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology; D011666:Pulmonary Valve Stenosis / Q000000981:diagnostic imaging / Q000473:pathology; D013771:Tetralogy of Fallot / Q000000981:diagnostic imaging / Q000473:pathology*; D016216:Ultrasonography, Prenatal