title: Pain and Interoception Imaging Network (PAIN): A multimodal, multisite, brain-imaging repository for chronic somatic and visceral pain disorders.
abstract: The Pain and Interoception Imaging Network (PAIN) repository (painrepository.org) is a newly created NIH (NIDA/NCCAM) funded neuroimaging data repository that aims to accelerate scientific discovery regarding brain mechanisms in pain and to provide more rapid benefits to pain patients through the harmonization of efforts and data sharing. The PAIN Repository consists of two components, an Archived Repository and a Standardized Repository. Similar to other 'open' imaging repositories, neuroimaging researchers can deposit any dataset of chronic pain patients and healthy controls into the Archived Repository. Scans in the Archived Repository can be very diverse in terms of scanning procedures and clinical metadata, complicating the merging of datasets for analyses. The Standardized Repository overcomes these limitations through the use of standardized scanning protocols along with a standardized set of clinical metadata, allowing an unprecedented ability to perform pooled analyses. The Archived Repository currently includes 741 scans and is rapidly growing. The Standardized Repository currently includes 433 scans. Pain conditions currently represented in the PAIN repository include: irritable bowel syndrome, vulvodynia, migraine, chronic back pain, and inflammatory bowel disease. Both the PAIN Archived and Standardized Repositories promise to be important resources in the field of chronic pain research. The enhanced ability of the Standardized Repository to combine imaging, clinical and other biological datasets from multiple sites in particular make it a unique resource for significant scientific discoveries.
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Department of Medicine at UCLA, Los Angeles, CA, USA; Department of Physiology at UCLA, Los Angeles, CA, USA; Department of Psychiatry at UCLA, Los Angeles, CA, USA; Pain and Interoception Network (PAIN) at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Labus
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Department of Medicine at UCLA, Los Angeles, CA, USA; Department of Physiology at UCLA, Los Angeles, CA, USA; Department of Psychiatry at UCLA, Los Angeles, CA, USA; Pain and Interoception Network (PAIN) at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Bruce
authors.initials: B
authors.lastname: Naliboff
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Department of Medicine at UCLA, Los Angeles, CA, USA; Pain and Interoception Network (PAIN) at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Kilpatrick
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Department of Medicine at UCLA, Los Angeles, CA, USA; Pain and Interoception Network (PAIN) at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Cathy
authors.initials: C
authors.lastname: Liu
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Department of Medicine at UCLA, Los Angeles, CA, USA; Pain and Interoception Network (PAIN) at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Cody
authors.initials: C
authors.lastname: Ashe-McNalley
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Department of Medicine at UCLA, Los Angeles, CA, USA; Pain and Interoception Network (PAIN) at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Ivani R
authors.initials: IR
authors.lastname: Dos Santos
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA.
authors.forename: Mher
authors.initials: M
authors.lastname: Alaverdyan
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Davis
authors.initials: D
authors.lastname: Woodworth
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Department of Medicine at UCLA, Los Angeles, CA, USA; Pain and Interoception Network (PAIN) at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Arpana
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Ellingson
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Department of Medicine at UCLA, Los Angeles, CA, USA; Department of Physiology at UCLA, Los Angeles, CA, USA; Department of Psychiatry at UCLA, Los Angeles, CA, USA; VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Pain and Interoception Network (PAIN) at UCLA, Los Angeles, CA 90095, USA.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Tillisch
authors.affiliation: Oppenheimer Family Center for the Neurobiology of Stress at UCLA, Los Angeles, CA, USA; Department of Medicine at UCLA, Los Angeles, CA, USA; Department of Physiology at UCLA, Los Angeles, CA, USA; Department of Psychiatry at UCLA, Los Angeles, CA, USA; Pain and Interoception Network (PAIN) at UCLA, Los Angeles, CA 90095, USA. Electronic address: emayer@ucla.edu.
authors.forename: Emeran A
authors.initials: EA
authors.lastname: Mayer
mesh_terms: D022126:Access to Information; D059350:Chronic Pain / Q000175:diagnosis* / Q000473:pathology*; D003628:Database Management Systems; D016208:Databases, Factual; D006801:Humans; D033181:Information Dissemination; D059906:Neuroimaging; D059408:Pain Management; D059265:Visceral Pain
keywords: Archived repository; Chronic pain; Large biological datasets; Multiple sites; Neuroimaging data repository; Standardized repository