title: Effects of diesel exhaust particles on microRNA-21 in human bronchial epithelial cells and potential carcinogenic mechanisms.
abstract: Air pollution plays a role in cancer risk, particularly in lung cancer, which is the leading cause of cancer-related mortality worldwide. Diesel exhaust particles (DEPs), a component of diesel exhaust products, is a complex mixture of particle compounds that include a large number of known and suspected human carcinogens. Historically, lung cancer, which is associated with DEPs, has been the focus of attention as a health risk in human and animal studies. However, the mechanism by which DEPs cause lung cancer remains unclear. The present study reports that DEPs increased miR-21 expression and then activated the PTEN/PI3K/AKT pathway in human bronchial epithelial (HBE) cells, which may serve as an important carcinogenic mechanism. However, the data revealed that short-term exposure to a high DEP concentration did not cause evident cell carcinogenesis in HBE cells.
authors.affiliation: Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhou
authors.affiliation: Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors.forename: Suli
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors.forename: Wenliang
authors.initials: W
authors.lastname: Jia
authors.affiliation: State Key Laboratory of Internal Combustion Engine Fuel Science of Tianjin University, Tianjin 300072, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Lv
authors.affiliation: State Key Laboratory of Internal Combustion Engine Fuel Science of Tianjin University, Tianjin 300072, P.R. China.
authors.forename: Chonglin
authors.initials: C
authors.lastname: Song
authors.affiliation: Department of Neurosurgery, Tianjin Medical University General Hospital and Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin 300052, P.R. China.
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Kang
authors.affiliation: Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China.
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002273:Carcinogens / Q000633:toxicity*; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D003094:Collagen / Q000737:chemistry; D004338:Drug Combinations; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D007797:Laminin / Q000737:chemistry; D035683:MicroRNAs / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D052638:Particulate Matter / Q000633:toxicity*; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D011509:Proteoglycans / Q000737:chemistry; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D004338:Drug Combinations; D007797:Laminin; C524940:MIRN21 microRNA, human; D035683:MicroRNAs; D052638:Particulate Matter; D011509:Proteoglycans; D001335:Vehicle Emissions; C059485:matrigel; D003094:Collagen; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human