title: [Unresolved problems and the prospects for research in area of the multiple sclerosis: virologic, immunologic and therapeutic aspects].
abstract: Multiple sclerosis--important and unsolved problem of modern neurology. Despite a great deal of publications, in the modern theory of multiple sclerosis there remain many unresolved problems, without solving of which no further advances in the diagnosis and treatment can be possible. The present work elucidates blind spots in pathogenesis of the disease to indicate the most perspective directions of research, the results of which would allow the optimization of existing diagnostic and therapeutic algorithms. Microbial triggers, immunopathological mechanisms, association with immunodeficiencies, efficacy of the immunotherapy and side effects of the immunosuppressants as well as additional antimicrobial treatment are discussed.
authors.forename: D V
authors.initials: DV
authors.lastname: Mal'tsev
mesh_terms: D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D000068717:Glatiramer Acetate; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000472:pathogenicity; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007167:Immunotherapy; D016899:Interferon-beta / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D010455:Peptides / Q000627:therapeutic use; D019349:Roseolovirus Infections / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000628:therapy*
chemical_list: D007166:Immunosuppressive Agents; D010455:Peptides; D000068717:Glatiramer Acetate; D016899:Interferon-beta