title: Intervention effect of traditional Chinese medicine Yi Tang Kang on metabolic syndrome of spleen deficiency.
abstract: OBJECTIVE
  To investigate effects of herbal compound Yi Tang Kang on the spleen deficiency metabolic syndrome.
  
  
  METHODS
  Forty male Wistar rats were randomly divided into two groups: the normal control group and the MS spleen deficiency syndrome group. The control group rats were fed with standard diet and water, while MS spleen deficiency syndrome group with high fat diet and low dose intraperitoneal injection of streptozocin, which swam to the endurance limit. After 12 weeks, the MS spleen deficiency syndrome group was randomly divided into two groups, with 13 rats in each group. Rats in model group were fed with high fat diet and continuouly administered with daily saline, and rats in intervention group with high fat diet were trated with traditional Chinese medicines Yi Tang Kang by gavage, 2 mL/200 g at the same time every day. 10 weeks later, the expression of serum proteomics was investigated through abdominal aortic puncture and separation of serum, using isotope labeling technique, high performance liquid chromatography and four bar-Orbitrap mass spectrometer.
  
  
  RESULTS
  After treatment with traditional Chinese medicine yitangkang, in the model group, important carboxylesterase and retinal guanylate cyclase 2 precursor were upregulated. As for intervention group, these indesxes were raised, but immunoglobulin IgG, carnitine acetyltransferase, tubulin beta -5, and Gan Lu sugar binding protein C were down-regulated. At the same time, some new biological active substances, such as protein tyrosine kinase, beta glucosidase were also found.
  
  
  CONCLUSIONS
  Traditional Chinese medicines Yi Tang Kang could regulate glucose and lipid metabolism in rats with spleen deficiency syndrome.
authors.affiliation: Department of endocrinology, Affiliated Hospital of Liaoning University of TMC, Shenyang 110032, China.
authors.forename: Xiao-Xi
authors.initials: XX
authors.lastname: Liu
authors.affiliation: Department of endocrinology, Affiliated Hospital of Liaoning University of TMC, Shenyang 110032, China. Electronic address: shiyan@lnutcm.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
keywords: Proteomics; Spleen deficiency syndrome; Yi Tang Kang