title: Large cell differentiation of metastatic prostate cancer after androgen deprivation therapy.
abstract: We present a case of a 75-year-old male with a history of high risk prostate cancer who underwent androgen deprivation therapy and palliative radiation treatments for his disease. Subsequently, he presented with gross hematuria and severe lower urinary tract symptoms. A palliative transurethral resection of the prostate (TURP) at that time, demonstrated large cell differentiated neuroendocrine carcinoma with metastasis to the lung. We review the limited literature on this rare form of disease and present current treatment strategies.
authors.affiliation: Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
authors.forename: Rutveej
authors.initials: R
authors.lastname: Patel
authors.forename: Izak
authors.initials: I
authors.lastname: Faiena
authors.forename: Jules
authors.initials: J
authors.lastname: Geltzeiler
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000728:Androgens / Q000172:deficiency; D018278:Carcinoma, Neuroendocrine / Q000556:secondary*; D002454:Cell Differentiation; D003131:Combined Modality Therapy; D004358:Drug Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000628:therapy*; D011878:Radiotherapy; D020728:Transurethral Resection of Prostate; D016896:Treatment Outcome
chemical_list: D000726:Androgen Antagonists; D000728:Androgens