title: Changes in blood CD4+T and CD8+T lymphocytes in stressed rats pretreated chronically with desipramine are more pronounced after chronic open field stress challenge.
abstract: The present study examines the influence of a chronic (14 consecutive days) desipramine (10mg/kg i.p.) pretreatment by itself vs. after chronic (7 consecutive day) open-field (OF) on immune system alterations in response to acute (30 min) OF in Wistar rats (n=60). Opposing to the effect of desipramine injected alone, the combined pretreatment after chronic OF challenge exerts suppressive effects on peripheral blood T/B, CD4(+)T-helper/inducer and CD8(+)T-cytotoxic/suppressor but not NK cell number, decreased interferon-γ/interleukin-10 ratio and thymus weight in the stressed rats. It suggests that chronic stress exposure is important for the immunomodulatory effects of pretreatment with antidepressants.
authors.affiliation: Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Listowska
authors.affiliation: Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Glac
authors.affiliation: Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland.
authors.forename: Beata
authors.initials: B
authors.lastname: Grembecka
authors.affiliation: Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Grzybowska
authors.affiliation: Department of Animal and Human Physiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland. Electronic address: wronada3@o2.pl.
authors.forename: Danuta
authors.initials: D
authors.lastname: Wrona
mesh_terms: D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood; D003891:Desipramine / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005106:Exploratory Behavior; D005434:Flow Cytometry; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D007962:Leukocytes / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000929:Antidepressive Agents, Tricyclic; D016753:Interleukin-10; D007371:Interferon-gamma; D003891:Desipramine; D003345:Corticosterone
keywords: Antidepressants; CD4(+)/CD8(+)T cell ratio; Desipramine; IFN-γ/IL-10 ratio; Open field stress; Rat