title: Impact of the C1431T Polymorphism of the Peroxisome Proliferator Activated Receptor-Gamma (PPAR-γ) Gene on Fasted Serum Lipid Levels in Patients with Coronary Artery Disease.
abstract: OBJECTIVE
  The C1431T polymorphism of peroxisome proliferator activated receptor-γ (PPAR-γ) gene is related to diabetes and metabolic-syndrome. However, studies have been inconclusive about its association with coronary artery disease (CAD) and there have been no studies analyzing the association of this polymorphism with fasted-serum-lipid levels in Iranian-individuals with CAD. We investigated the association of PPAR-γ C1431T-polymorphism with CAD and dyslipidaemia in 787 individuals.
  
  
  METHODS
  Anthropometric-parameters and biochemical-measurements were evaluated, followed by genotyping. The association of the genetic-polymorphisms with CAD and lipid-profile was determined by univariate/multivariate-analyses.
  
  
  RESULTS
  Patients with CT or CT+TT genotype were at an increased-risk of CAD relative to CC-carriers (adjusted odds ratio: 2.03; 95% confidence interval, 1.01-4.09; p = 0.046). However, in the larger population, CT genotype was present at a higher frequency in the group with a positive angiogram. Furthermore, CT+TT genotypes were associated with an altered fasted-lipid-profile in the initial population sample of patients with a positive angiogram, compared to the group with a negative-angiogram. The angiogram-positive patients carrying the T allele had a significantly higher triglyceride, serum C-reactive protein and fasting-blood-glucose.
  
  
  CONCLUSIONS
  We have found the PPAR-γ C1431T polymorphism was significantly associated with fasted serum lipid profile in individuals with angiographically defined CAD. Since accumulating data support the role of PPAR-γ polymorphisms in CAD, further studies are required to investigate the association of this polymorphism with coronary artery disease.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Oladi
authors.forename: Mahdi
authors.initials: M
authors.lastname: Nohtani
authors.forename: Amir
authors.initials: A
authors.lastname: Avan
authors.forename: Seyed Reza
authors.initials: SR
authors.lastname: Mirhafez
authors.forename: Amir
authors.initials: A
authors.lastname: Tajbakhsh
authors.forename: Faezeh
authors.initials: F
authors.lastname: Ghasemi
authors.forename: Asadollah
authors.initials: A
authors.lastname: Asadi
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Elahdadi Salmani
authors.forename: Akram
authors.initials: A
authors.lastname: Mohammadi
authors.forename: Leila
authors.initials: L
authors.lastname: Hoseinzadeh
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour Mobarhan
mesh_terms: D000328:Adult; D003327:Coronary Disease / Q000097:blood* / Q000235:genetics*; D003430:Cross-Sectional Studies; D005215:Fasting; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D008055:Lipids; D047495:PPAR gamma