title: Visuoperceptual assessments for differentiating dementia with Lewy bodies and Alzheimer's disease: illusory contours and other neuropsychological examinations.
abstract: We examined the utility of illusory contours (ICs) for the differentiation of dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). Thirty-five probable DLB patients, 35 probable AD patients controlled by age, years of education, and Mini-Mental State Examination (MMSE) score, and 30 cognitively normal subjects controlled by age and years of education underwent visuoperceptual examinations including ICs, pentagon copying in MMSE, overlapping figures, clock drawing test, cube copying, and line orientation. Four items in ICs (ICs-4) were found to be significantly impaired in DLB compared with AD, and a sensitivity and a specificity of total score of ICs-4 were 88.6% and 37.1%, respectively. When a score of ICs-4 is combined with a 10-point scaled score of pentagon copying in MMSE, a sensitivity and a specificity were 77.1% and 82.9%, respectively. The present study suggests that ICs-4 can be included in neuropsychological examinations to assess visuoperceptual impairment in DLB.
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo 136-0075, Japan.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Ota
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo 136-0075, Japan Department of Health Science, School of Allied Health Sciences, Kitasato University, Kanagawa 252-0373, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Murayama
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo 136-0075, Japan Department of Psychiatry, Juntendo University School of Medicine, Tokyo 113-8431, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Kasanuki
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo 136-0075, Japan.
authors.forename: Daizo
authors.initials: D
authors.lastname: Kondo
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo 136-0075, Japan.
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Fujishiro
authors.affiliation: Department of Psychiatry, Juntendo University School of Medicine, Tokyo 113-8431, Japan.
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo 136-0075, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sato
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo 136-0075, Japan Department of Psychiatry, Juntendo University School of Medicine, Tokyo 113-8431, Japan iseki@juntendo.gmc.ac.jp.
authors.forename: Eizo
authors.initials: E
authors.lastname: Iseki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007088:Illusions / Q000523:psychology*; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000523:psychology; D008297:Male; D009483:Neuropsychological Tests; D012680:Sensitivity and Specificity; D014796:Visual Perception / Q000502:physiology*
keywords: Alzheimer's disease; Dementia with Lewy bodies; Illusory contours; Visuoperceptual examinations; Visuoperceptual impairment