title: Medical consultant system for improving lung transplantation opportunities and outcomes in Japan.
abstract: Because the shortage of donor organs is especially serious in Japan, since 2002 a unique partnership between transplant consultant physicians and local physicians has been developed to maximize the organ utilization rate. Since 2011, more than 25 lung consultant physicians have been registered to specifically assess donor lungs and provide advice on intensive respiratory care to donors. In this study, we retrospectively reviewed the efficacy of this system for lung transplantation opportunities and outcomes. One hundred eighty-seven brain-dead lung donor candidates were chronologically divided into 3 phases: I (May 1998-November 2006) and II (December 2006-January 2011), before and after medical consultants requested that local physicians administer aggressive bronchial suctioning using bronchoscopy, respectively; and phase III (February 2011-January 2013), after the emergence of lung consultants. The lung utilization rate, Pao2/Fio2 ratio at the first and second brain death examinations and at the tertiary assessment before recovery, and graft survival were analyzed. The lung utilization rate was significantly higher in phases II and III than in phase I. In phases I and II, the Pao2/Fio2 ratio at the tertiary assessment was significantly lower than that at the first or the second brain death examination, whereas it did not worsen with time in phase III. Graft survival was significantly better in phases II and III than in phase I. Graft death due to primary graft dysfunction was significantly more frequent in phase I than in phases II and III. In conclusion, this system is effective in improving lung transplantation opportunities and outcomes.
authors.affiliation: Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan. Electronic address: hoshikawa@idac.tohoku.ac.jp.
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshikawa
authors.affiliation: Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.affiliation: Japan Organ Transplant Network, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Ashikari
authors.affiliation: Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
authors.affiliation: Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Niikawa
authors.affiliation: Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Noda
authors.affiliation: Department of Thoracic Surgery, Dokkyo Medical University, Mibu-machi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sado
authors.affiliation: Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Notsuda
authors.affiliation: Department of Thoracic Surgery, Kyoto University, Kyoto, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Miyoshi
authors.affiliation: Department of Thoracic Surgery, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shiraishi
authors.affiliation: Division of Surgical Oncology, Department of Translational Medical Science, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.affiliation: Department of Thoracic Surgery, Dokkyo Medical University, Mibu-machi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Chida
authors.affiliation: Department of Therapeutics for End-Stage Organ Dysfunction, Graduate School of Medicine, Suita, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Fukushima
authors.affiliation: Department of Thoracic Surgery, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kondo
mesh_terms: D000328:Adult; D001926:Brain Death; D005260:Female; D006085:Graft Survival; D006801:Humans; D007564:Japan; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D055031:Primary Graft Dysfunction / Q000453:epidemiology / Q000209:etiology; D012017:Referral and Consultation / Q000458:organization & administration*; D012189:Retrospective Studies; D014019:Tissue Donors / Q000600:supply & distribution*