title: Heteroatom-substituted tetra(3,4-pyrido)porphyrazines: a stride toward near-infrared-absorbing macrocycles.
abstract: A synthesis procedure for heteroatom-substituted tetra(3,4-pyrido)porphyrazines that absorb light near 800 nm was developed. Based on the observed relationships between the structure and photophysical parameters, a novel highly photodynamically active (IC50 = 0.26 μM) compound was synthesized and biologically characterized.
authors.affiliation: Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05, Hradec Kralove, Czech Republic. petr.zimcik@faf.cuni.cz.
authors.forename: Lenka
authors.initials: L
authors.lastname: Vachova
authors.forename: Miloslav
authors.initials: M
authors.lastname: Machacek
authors.forename: Radim
authors.initials: R
authors.lastname: Kučera
authors.forename: Jiri
authors.initials: J
authors.lastname: Demuth
authors.forename: Pavel
authors.initials: P
authors.lastname: Cermak
authors.forename: Kamil
authors.initials: K
authors.lastname: Kopecky
authors.forename: Miroslav
authors.initials: M
authors.lastname: Miletin
authors.forename: Adela
authors.initials: A
authors.lastname: Jedlickova
authors.forename: Tomas
authors.initials: T
authors.lastname: Simunek
authors.forename: Veronika
authors.initials: V
authors.lastname: Novakova
authors.forename: Petr
authors.initials: P
authors.lastname: Zimcik
mesh_terms: D008027:Light; D047028:Macrocyclic Compounds / Q000737:chemistry*; D015394:Molecular Structure; D010777:Photochemistry; D011166:Porphyrins / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared; D013329:Structure-Activity Relationship
chemical_list: D047028:Macrocyclic Compounds; D011166:Porphyrins