title: [Impact of obesity on pathologic outcomes and biochemical reccurence after radical prostatectomy].
abstract: OBJECTIVE
  To determine whether obesity is associated with adverse pathologic characteristics, positive surgical margins and the biochemical recurrence free survival (bRFS) after primary treatment with radical prostatectomy (RP).
  
  
  METHODS
  Medical charts of patients managed with RP between 1999 and 2011 for localized prostate cancer (PCa) were retrospectively reviewed. Population study was split into two groups according to the body mass index (BMI): non obese (BMI< 30 kg/m(2)) and obese (BMI ≥ 30 kg/m(2)). Correlations between obesity and adverse pathological features or bRFS were assessed using univariable and multivariable analyses.
  
  
  RESULTS
  Overall, 328 patients were included in the present study: 278 (84.8%) obese and 50 (15.2%) non obese. In multivariable analysis, obesity was associated with positive surgical margins (P=0.014), extracapsular extension (P=0.004) and pathologic Gleason score ≥ 7 (P=0.048). Obesity was not associated with seminal vesicle invasion (P=0.636) and lymph node metastasis (P=0.132). After a mean follow-up of 60.51 ± 28.82 months, no statistical difference in terms of bRFS was observed between the two groups (P=0.186). Furthermore, obesity was not an independent predictor of bFS in multivariable analysis.
  
  
  CONCLUSIONS
  Obesity was associated with adverse pathologic characteristics and positive surgical margins but no statistical correlation was found with bRFS.
  
  
  METHODS
  5.
authors.affiliation: Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France; Université de Franche-Comté, 25000 Besançon, France.
authors.forename: L
authors.initials: L
authors.lastname: Balssa
authors.affiliation: Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France; Université de Franche-Comté, 25000 Besançon, France.
authors.forename: J
authors.initials: J
authors.lastname: Pastori
authors.affiliation: Service d'urologie, CHI de Haute-Saône, 25000 Vesoul, France.
authors.forename: J
authors.initials: J
authors.lastname: Lillaz
authors.affiliation: Université de Franche-Comté, 25000 Besançon, France; Service de chirurgie plastique, CHRU de Besançon, 25000 Besançon, France.
authors.forename: M
authors.initials: M
authors.lastname: Panouillères
authors.affiliation: Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France.
authors.forename: G
authors.initials: G
authors.lastname: Guichard
authors.affiliation: Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France.
authors.forename: S
authors.initials: S
authors.lastname: Bernardini
authors.affiliation: Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France.
authors.forename: E
authors.initials: E
authors.lastname: Chabannes
authors.affiliation: Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France; Université de Franche-Comté, 25000 Besançon, France.
authors.forename: H
authors.initials: H
authors.lastname: Bittard
authors.affiliation: Université de Franche-Comté, 25000 Besançon, France; Service d'oncologie médicale, CHRU de Besançon, 25000 Besançon, France; Inserm UMR 1098, 25000 Besançon, France.
authors.forename: A
authors.initials: A
authors.lastname: Thiery-Vuillemin
authors.affiliation: Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France; Université de Franche-Comté, 25000 Besançon, France; Inserm UMR 1098, 25000 Besançon, France. Electronic address: francois.kleinclauss@univ-fcomte.fr.
authors.forename: F
authors.initials: F
authors.lastname: Kleinclauss
mesh_terms: D000368:Aged; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D009765:Obesity / Q000150:complications*; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Cancer de la prostate; Obesity; Obésité; Oncological outcomes; Prostate cancer; Prostatectomie totale; Radical prostatectomy; Survie