title: Alternative Splicing, DNA Damage and Modulating Drugs in Radiation Therapy for Cancer.
abstract: Radiotherapy effectively destroys cancer cells in many sites of the body, but several limitations remain. This study investigated alternative splicing, which is a common mechanism of increased diversity in mRNAs and proteins. The relationships of alternative splicing to DNA damage and radiation such as UV and ionizing radiation were analyzed. The DNA damage responses of many genes involved in alternative splicing were compared between non-radiation and radiation treatments. Drugs that affect radioresistence or radiosensitization by modulating the effects of alternative splicing and radiation were also reviewed.
authors.forename: Jen-Yang
authors.initials: JY
authors.lastname: Tang
authors.forename: Ruei-Nian
authors.initials: RN
authors.lastname: Li
authors.forename: Ping-Ho
authors.initials: PH
authors.lastname: Chen
authors.forename: Hurng-Wern
authors.initials: HW
authors.lastname: Huang
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Hou
authors.affiliation: Cancer Center, Kaohsiung Medical University Hospital; Kaohsiung Medical University, Kaohsiung, Taiwan. mifeho@kmu.edu.tw.
authors.forename: Hsueh-Wei
authors.initials: HW
authors.lastname: Chang
mesh_terms: D017398:Alternative Splicing / Q000187:drug effects*; D004249:DNA Damage / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012333:RNA, Messenger / Q000235:genetics; D011836:Radiation Tolerance / Q000235:genetics
chemical_list: D004364:Pharmaceutical Preparations; D012333:RNA, Messenger