title: Augmentation of Evidence-Based Psychotherapy for PTSD With Cognitive Enhancers.
abstract: Exposure-based therapy has proven to be useful to treat various anxiety disorders as well as post-traumatic stress disorder (PTSD). Despite its efficacy, a fair proportion of patients remain symptomatic after treatment. Different lines of research have put considerable efforts to investigate ways to enhance the efficacy of exposure-based therapy, which could ultimately lead to better clinical outcomes for patients. Given that this type of therapy relies on extinction learning principles, neuroscience research has tested different adjuncts that could be used as cognitive enhancers through their impact on extinction learning and its consolidation. The current review will summarize some of the latest compounds that have received attention and show some promise to be used in clinical settings to improve the efficacy of exposure-based therapy.
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Charlestown, MA, 02129, USA.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Marin
authors.forename: Sylwia Fowler
authors.initials: SF
authors.lastname: Lonak
authors.forename: Mohammed R
authors.initials: MR
authors.lastname: Milad
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000818:Animals; D001008:Anxiety Disorders / Q000628:therapy; D003523:Cycloserine / Q000627:therapeutic use; D063388:Endocannabinoids / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use; D006801:Humans; D008751:Methylene Blue / Q000627:therapeutic use; D018697:Nootropic Agents / Q000627:therapeutic use*; D011613:Psychotherapy; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy* / Q000523:psychology / Q000628:therapy
chemical_list: D000319:Adrenergic beta-Antagonists; D063388:Endocannabinoids; D004967:Estrogens; D056572:Histone Deacetylase Inhibitors; D018697:Nootropic Agents; D003523:Cycloserine; D008751:Methylene Blue