title: The association of perioperative autologous blood transfusion with the early postoperative cognitive dysfunction in aged patients following lumbar surgery.
abstract: OBJECTIVE
  Intraoperation autologous blood transfusion is an effective method that is used in surgeries with an important blood loss. Several studies suggest that massive blood transfusion is one of the independent risks for postoperative cognitive dysfunction (POCD). Whether the autologous blood is one of the risk factor for POCD or not, we retrospectively examined the incidence of POCD and the probable risk factors in patients undergoing lumbar surgery in our hospital, with the same aged non-POCD patients as controls.
  
  
  METHODS
  Eighty-one patients who underwent lumbar surgery were included. Perioperative data were examined for association with POCD on the 7 postoperative days by a Mini-Mental State Test. Multivariable logistic regression analysis was conducted to determine the probable risks associated with POCD.
  
  
  RESULTS
  POCD was found in 21 patients. Participants who developed POCD were more likely to had a lower eduction level, more likely to had more blood loss, higher incidence of preoperative anemia, and perioperative allogeneic blood transfusion of more than 3 units as independent risk factors for POCD 7 d postoperatively (P < 0.05). Otherwise, there is no significant difference of the patients received autologous blood or not (P > 0.05).
  
  
  CONCLUSIONS
  Autologous blood transfusion is not a risk factor for POCD in aged patients following lumbar surgery. Autologous blood is likely to be a better method of intraoperative blood transfusion during lumbar spine surgery.
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Yanna
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Na
authors.initials: N
authors.lastname: Xing
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Zhisong
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Jinhu
authors.initials: J
authors.lastname: Xue
authors.affiliation: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Henan, China. Electronic address: zhangw571012@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001804:Blood Transfusion, Autologous; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D019990:Perioperative Care; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology*; D012307:Risk Factors
keywords: Autologous blood transfusion; Lumbar surgery; Postoperative cognitive dysfunction