title: Complement and platelets: Mutual interference in the immune network.
abstract: In recent years, the view of platelets has changed from mere elements of hemostasis to immunological multitaskers. They are connected in manifold ways to other cellular and humoral components of the immune network, one of which is the complement system, a potent player in soluble innate immunity. Our article reviews the crucial and complex interplay between platelets and complement, focusing on mutual regulation of these two interaction partners by their respective molecular mechanisms. Furthermore, the putative relevance of these processes to infectious diseases, inflammatory conditions, and autoimmune disorders, as well as the treatment of patients with biomaterials is highlighted.
authors.affiliation: Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Speth
authors.affiliation: Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: guenter.rambach@i-med.ac.at.
authors.forename: Günter
authors.initials: G
authors.lastname: Rambach
authors.affiliation: Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Würzner
authors.affiliation: Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Lass-Flörl
authors.affiliation: Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
authors.forename: Huda
authors.initials: H
authors.lastname: Kozarcanin
authors.affiliation: Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
authors.forename: Osama A
authors.initials: OA
authors.lastname: Hamad
authors.affiliation: Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
authors.forename: Bo
authors.initials: B
authors.lastname: Nilsson
authors.affiliation: Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Linnæus Center of Biomaterials Chemistry, Linnæus University, SE-391 82 Kalmar, Sweden.
authors.forename: Kristina N
authors.initials: KN
authors.lastname: Ekdahl
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D001792:Blood Platelets / Q000276:immunology* / Q000473:pathology; D003167:Complement Activation; D003180:Complement C3b Inactivator Proteins / Q000235:genetics / Q000276:immunology; D003165:Complement System Proteins / Q000235:genetics / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D009181:Mycoses / Q000235:genetics / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D011951:Receptors, Complement / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000821:virology
chemical_list: D003180:Complement C3b Inactivator Proteins; D011951:Receptors, Complement; D003165:Complement System Proteins
keywords: Autoimmunity and inflammatory disorders; Biomaterials; Complement; Immune network; Infectious diseases; Innate immunity; Platelets