title: Effects of High-Intensity Intermittent Exercise Training on Appetite Regulation.
abstract: OBJECTIVE
  An acute bout of high-intensity intermittent exercise suppresses ad libitum energy intake at the postexercise meal. The present study examined the effects of 12 wk of high-intensity intermittent exercise training (HIIT) compared with moderate-intensity continuous exercise training (MICT) on appetite regulation.
  
  
  METHODS
  Thirty overweight inactive men (body mass index, 27.2 ± 1.3 kg·m(-2); V˙O2peak, 35.3 ± 5.3 mL·kg(-1)·min(-1) were randomized to either HIIT or MICT (involving 12 wk of training, three sessions per week) or a control group (CON) (n = 10 per group). Ad libitum energy intake from a laboratory test meal was assessed after both a low-energy (847 kJ) and a high-energy preload (2438 kJ) before and after the intervention. Perceived appetite and appetite-related blood variables were also measured.
  
  
  RESULTS
  There was no significant effect of the intervention period on energy intake at the test meal after the two different preloads (P ≥ 0.05). However, the 95% confidence interval indicated a clinically meaningful decrease in energy intake after the high-energy preload compared with the low-energy preload in response to HIIT (516 ± 395 kJ decrease), but not for MICT or CON, suggesting improved appetite regulation. This was not associated with alterations in the perception of appetite or the circulating concentration of a number of appetite-related peptides or metabolites, although insulin sensitivity was enhanced with HIIT only (P = 0.003).
  
  
  CONCLUSIONS
  HIIT seems to benefit appetite regulation in overweight men. The mechanisms for this remain to be elucidated.
authors.affiliation: 1School of Sport Science, Exercise and Health, University of Western Australia, Perth, Western Australia, AUSTRALIA; and 2School of Psychology and Exercise Science, Murdoch University, Perth, Western Australia, AUSTRALIA.
authors.forename: Aaron Y
authors.initials: AY
authors.lastname: Sim
authors.forename: Karen E
authors.initials: KE
authors.lastname: Wallman
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Fairchild
authors.forename: Kym J
authors.initials: KJ
authors.lastname: Guelfi
mesh_terms: D001069:Appetite Regulation / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D004151:Dipeptides / Q000097:blood; D002149:Energy Intake; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods; D054439:Ghrelin / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D050177:Overweight / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D010191:Pancreatic Polypeptide / Q000097:blood; D010806:Physical Education and Training / Q000379:methods*
chemical_list: D001786:Blood Glucose; D004151:Dipeptides; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; C042696:tyrosyltyrosine; D010191:Pancreatic Polypeptide