title: Sickle cell disease and venous thromboembolism in pregnancy and the puerperium.
abstract: Recent data strongly suggest an increased risk of venous thromboembolism in subjects with sickle cell disease and to a lesser extent, sickle cell trait. However, most studies have been retrospective, case-control or cross-sectional based on data obtained from administrative databases. More data from adequately powered prospective studies that include matched controls are needed to definitely establish the link between venous thromboembolism during pregnancy and sickle hemoglobin disorders. Similarly, there remains a need for properly designed randomized control trials to establish the safety of various hormonal contraceptive methods in women with sickle cell disorders.
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, NC, USA.
authors.forename: Denis
authors.initials: D
authors.lastname: Noubouossie
authors.affiliation: Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, NC, USA. Electronic address: nigel_key@med.unc.edu.
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Key
mesh_terms: D000755:Anemia, Sickle Cell / Q000175:diagnosis* / Q000453:epidemiology*; D015984:Causality; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D049590:Postpartum Period; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000453:epidemiology*; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000175:diagnosis* / Q000453:epidemiology*
keywords: Contraception; Pregnancy; Sickle cell disease; Sickle cell trait; Venous thromboembolism