title: PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases.
abstract: DNA damage is the prime activator of the enzyme poly(ADP-ribose)polymerase1 (PARP-1) whose overactivation has been proven to be associated with the pathogenesis of numerous central nervous system disorders, such as ischemia, neuroinflammation, and neurodegenerative diseases. Under oxidative stress conditions PARP-1 activity increases, leading to an accumulation of ADP-ribose polymers and NAD(+) depletion, that induces energy crisis and finally cell death. This review aims to explain the contribution of PARP-1 in neurodegenerative diseases, focusing on Alzheimer's and Parkinson's disease, to stimulate further studies on this issue and thereby engage a new perspective regarding the design of possible therapeutic agents or the identification of biomarkers.
authors.affiliation: Department of Biochemical Sciences, Sapienza University of Roma, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Martire
authors.affiliation: Department of Biochemical Sciences, Sapienza University of Roma, Italy.
authors.forename: Luciana
authors.initials: L
authors.lastname: Mosca
authors.affiliation: Department of Biochemical Sciences, Sapienza University of Roma, Italy. Electronic address: maria.derme@uniroma1.it.
authors.forename: Maria
authors.initials: M
authors.lastname: d'Erme
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D000818:Animals; D004734:Energy Metabolism; D006801:Humans; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000378:metabolism*
chemical_list: C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases
keywords: Alzheimer’s disease; Mitochondria; Parkinson’s disease; Poly(ADP-ribose)polymerase