title: A new triterpenoid compound from stems and leaves of American ginseng.
abstract: A new dammarane-type triterpenoid compound was isolated from stems and leaves of American ginseng. The structure of the new sapogenin was elucidated by the combined analysis of NMR and HR-ESI-MS as dammar-20S, 25S-epoxy-3β, 12β, 26-triol (1). Compound 1 showed cytotoxic effect on human SM7721 and human Hela cells in vitro.
authors.affiliation: a Institute of Frontier Medical Science, Jilin University , Changchun 130021 , P.R. China.
authors.forename: Liu
authors.initials: L
authors.lastname: Han
authors.affiliation: a Institute of Frontier Medical Science, Jilin University , Changchun 130021 , P.R. China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Li
authors.affiliation: a Institute of Frontier Medical Science, Jilin University , Changchun 130021 , P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: a Institute of Frontier Medical Science, Jilin University , Changchun 130021 , P.R. China.
authors.forename: Jin-Ping
authors.initials: JP
authors.lastname: Liu
authors.affiliation: a Institute of Frontier Medical Science, Jilin University , Changchun 130021 , P.R. China.
authors.forename: Ping-Ya
authors.initials: PY
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D005894:Panax / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000097669:Dammaranes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; D000097669:Dammaranes; C000609407:dammar-20S, 25S-epoxy-3beta, 12beta, 26-triol
keywords: 12β; 25S-epoxy-3β; 26-triol; cytotoxic effect; dammar-20S; dammarane-type triterpene; stems and leaves of American ginseng