title: Imaging of Tumor Angiogenesis for Radiologists--Part 1: Biological and Technical Basis.
abstract: Angiogenesis is a key cancer hallmark involved in tumor growth and metastasis development. Tumor angiogenesis is the process whereby new blood vessels are formed to supply nutrients and oxygen to support the growth of tumors. This article reviews the biological basis behind imaging features and the different imaging modalities used to assess the status of tumor neovasculature in vivo at different scales: structural, functional, and molecular.
authors.affiliation: Department of Radiology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. Electronic address: roberto.garcia.figueiras@sergas.es.
authors.forename: Roberto
authors.initials: R
authors.lastname: García-Figueiras
authors.affiliation: Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, England, UK.
authors.forename: Anwar R
authors.initials: AR
authors.lastname: Padhani
authors.affiliation: Klinik für Nuklearmedizin, Universitätsklinikum Ulm, Ulm, Germany.
authors.forename: Ambros J
authors.initials: AJ
authors.lastname: Beer
authors.affiliation: Department of Radiology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Baleato-González
authors.affiliation: Department of Radiology, Clínica Girona, IDI. University of Girona, Girona, Spain.
authors.forename: Joan C
authors.initials: JC
authors.lastname: Vilanova
authors.affiliation: Clinica Las Nieves SERCOSA, Health Time, Jaén, Spain, Department of Radiology, Case Western Reserve University. Cleveland, OH.
authors.forename: Antonio
authors.initials: A
authors.lastname: Luna
authors.affiliation: Department of Radiology, Hospital Clínic Barcelona, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Oleaga
authors.affiliation: Department of Radiotherapy, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gómez-Caamaño
authors.affiliation: Functional Imaging, Royal Marsden Hospital, Surrey, UK.
authors.forename: Dow-Mu
authors.initials: DM
authors.lastname: Koh
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D057054:Molecular Imaging; D009369:Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000000981:diagnostic imaging; D061088:Photoacoustic Techniques; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed / Q000379:methods; D014463:Ultrasonography