title: Oxidative stress, neurotoxicity, and non-specific immune responses in juvenile red sea bream, Pagrus major, exposed to different waterborne selenium concentrations.
abstract: Juvenile Pagrus major (mean length 15.8±1.6 cm, and mean weight 90.4±4.7 g) were exposed for 4 weeks with waterborne selenium concentration (0, 50, 100, 200, and 400 μg L(-1)). In oxidative stress indicators, liver and gill superoxide dismutase (SOD) activity and glutathione S-transferase (GST) activity were markedly elevated after 4 weeks exposure. Similarly, glutathione (GSH) level in liver and gill was also increased in response to the highest Se exposure after 4 weeks exposure. In neurotoxicity, AChE activity was inhibited in brain and muscle tissues by waterborne Se exposure. In the non-specific immune responses, lysozyme activity of plasma and kidney was significantly increased by waterborne Se exposure. Peroxidase activity and anti-protease activity were decreased at high Se concentration. The results suggest that waterborne Se exposure can induce significant oxidative stress, inhibition of AChE activity, and immunological alterations.
authors.affiliation: Department of Aquatic Life Medicine, Pukyong National University, Busan 608-737, Republic of Korea.
authors.forename: Jun-Hwan
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Aquatic Life Medicine, Pukyong National University, Busan 608-737, Republic of Korea. Electronic address: jckang@pknu.ac.kr.
authors.forename: Ju-Chan
authors.initials: JC
authors.lastname: Kang
mesh_terms: D000818:Animals; D005880:Gills / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009420:Nervous System / Q000187:drug effects*; D018384:Oxidative Stress; D021541:Sea Bream / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D012643:Selenium / Q000633:toxicity*; D018036:Selenium Compounds / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D018036:Selenium Compounds; D014874:Water Pollutants, Chemical; D005982:Glutathione Transferase; D005978:Glutathione; D012643:Selenium
keywords: Neurotoxicity; Non-specific immune response; Oxidative stress; Pagrus major; Selenium