title: Optical coherence tomography predicts visual outcome for pituitary tumors.
abstract: We evaluate if the relationship between optical coherence tomography (OCT) of the retinal nerve fibre layer (RNFL) and visual outcome continued over long-term visual recovery in 107 patients undergoing pituitary decompression. Recently, it has been recognized that OCT of the RNFL has prognostic value in predicting visual outcomes after surgery for chiasmal compression caused by pituitary tumours. Patients were followed up at three time points: pre-operative (visit 1), 6-10 weeks post-operative (visit 2) and 9-15 months follow-up (visit 3). We found that patients with thin pre-operative RNFL had more severe visual field defects (mean deviation [MD] -9.22 versus -3.96 decibels [dB]; p = 0.001), but pre-operative visual acuity (VA) was good in both normal and thin RNFL groups (Snellen VA 6/5 and 6/4; p = 0.039). For those with thin RNFL the greatest improvement was between visit 2 and 3 (MD -7.1 dB versus -3.4 dB, respectively; p < 0.001) compared with pre-operative -9.8 dB. Normal RNFL patients showed greatest improvement between visits 1 and 2 (pre-operative -4.8 dB, visit 2 -2.0 dB, visit 3 -0.9 dB; p = 0.001). For long-term follow-up, 81.0% of eyes with normal RNFL, compared to 37.1% with thin RNFL (p < 0.001), achieved an MD of -2.00 dB (final visit). At final follow-up, 97.5% of normal RNFL eyes achieved VA of 6/12 or better compared with 88.2% with thin RNFL (p = 0.034). Our results indicate that long-term visual recovery after surgical decompression of pituitary lesions is predicted by pre-operative OCT RNFL. Patients with normal RNFL thickness show an increased propensity for visual recovery. This effect continues after long-term follow-up, however, most visual recovery occurs within the first 6-10 weeks.
authors.affiliation: Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC, Australia. Electronic address: h.daneshmeyer@auckland.ac.nz.
authors.forename: Helen V
authors.initials: HV
authors.lastname: Danesh-Meyer
authors.affiliation: Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
authors.forename: Aaron
authors.initials: A
authors.lastname: Wong
authors.affiliation: Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
authors.forename: Taras
authors.initials: T
authors.lastname: Papchenko
authors.affiliation: Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
authors.forename: Kaliopy
authors.initials: K
authors.lastname: Matheos
authors.affiliation: Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia; Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC, Australia.
authors.forename: Stanley
authors.initials: S
authors.lastname: Stylli
authors.affiliation: Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia; Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Nichols
authors.affiliation: Department of Ophthalmology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
authors.forename: Chris
authors.initials: C
authors.lastname: Frampton
authors.affiliation: Center For Eye Research Australia, East Melbourne, VIC, Australia.
authors.forename: Mark
authors.initials: M
authors.lastname: Daniell
authors.affiliation: Shiley Eye Centre, University of California San Diego, La Jolla, CA, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Savino
authors.affiliation: Department of Neurosurgery, The Royal Melbourne Hospital, Parkville, VIC, Australia; Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, VIC, Australia.
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Kaye
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019299:Decompression, Surgical / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008266:Macula Lutea / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers; D019635:Neurosurgical Procedures / Q000009:adverse effects / Q000379:methods*; D009900:Optic Nerve / Q000601:surgery; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D020127:Recovery of Function; D041623:Tomography, Optical Coherence / Q000379:methods*; D016896:Treatment Outcome; D014786:Vision Disorders / Q000209:etiology; D014787:Vision Tests; D014794:Visual Fields; D055815:Young Adult
keywords: Optical coherence tomography; Pituitary tumor; Predictive outcome; Recovery; Vision