title: Static and dynamic posterior cingulate cortex nodal topology of default mode network predicts attention task performance.
abstract: Characterization of the default mode network (DMN) as a complex network of functionally interacting dynamic systems has received great interest for the study of DMN neural mechanisms. In particular, understanding the relationship of intrinsic resting-state DMN brain network with cognitive behaviors is an important issue in healthy cognition and mental disorders. However, it is still unclear how DMN functional connectivity links to cognitive behaviors during resting-state. In this study, we hypothesize that static and dynamic DMN nodal topology is associated with upcoming cognitive task performance. We used graph theory analysis in order to understand better the relationship between the DMN functional connectivity and cognitive behavior during resting-state and task performance. Nodal degree of the DMN was calculated as a metric of network topology. We found that the static and dynamic posterior cingulate cortex (PCC) nodal degree within the DMN was associated with task performance (Reaction Time). Our results show that the core node PCC nodal degree within the DMN was significantly correlated with reaction time, which suggests that the PCC plays a key role in supporting cognitive function.
authors.affiliation: Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an, 710049, China. linpan@mail.xjtu.edu.cn.|Center for Mind/Brain Sciences, University of Trento, Mattarello, 38100, Italy. linpan@mail.xjtu.edu.cn.|Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA. linpan@mail.xjtu.edu.cn.
authors.forename: Pan
authors.initials: P
authors.lastname: Lin
authors.affiliation: School of Information Technology, Jiangxi University of Finance and Economics, Nanchang, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Center for Mind/Brain Sciences, University of Trento, Mattarello, 38100, Italy.|Department of Cognitive and Education Sciences, University of Trento, Rovereto, 38068, Italy.
authors.forename: Jorge
authors.initials: J
authors.lastname: Jovicich
authors.affiliation: Center for Mind/Brain Sciences, University of Trento, Mattarello, 38100, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: De Pisapia
authors.affiliation: Medical Psychological Institute of Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA.
authors.forename: Chun S
authors.initials: CS
authors.lastname: Zuo
authors.affiliation: Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, VA, Boston Healthcare System, Brockton Division, Harvard Medical School, Boston, MA, 02301, USA.|Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.
authors.forename: James Jonathan
authors.initials: JJ
authors.lastname: Levitt
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009434:Neural Pathways / Q000502:physiology; D009483:Neuropsychological Tests; D011930:Reaction Time; D012146:Rest; D055815:Young Adult
keywords: Default mode network (DMN); Degree; Functional connectivity (FC); Posterior cingulate cortex (PCC); Task performance