title: Preventive and therapeutic effect of treadmill running on chronic stress-induced memory deficit in rats.
abstract: Previous results indicated that stress impairs learning and memory. In this research, the effects of preventive, therapeutic and regular continually running activity on chronic stress-induced memory deficit in rats were investigated. 70 male rats were randomly divided into seven groups as follows: Control, Sham, Stress-Rest, Rest-Stress, Stress-Exercise, Exercise-Stress and Exercise-Stress & Exercise groups. Chronic restraint stress was applied 6 h/day for 21days and treadmill running 1 h/day. Memory function was evaluated by the passive avoidance test. The results revealed that running activities had therapeutic effect on mid and long-term memory deficit and preventive effects on short and mid-term memory deficit in stressed rats. Regular continually running activity improved mid and long-term memory compared to Exercise-Stress group. The beneficial effects of exercise were time-dependent in stress conditions. Finally, data corresponded to the possibility that treadmill running had a more important role on treatment rather than on prevention on memory impairment induced by stress.
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Radahmadi
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: alaei@med.mui.ac.ir.
authors.forename: Hojjatallah
authors.initials: H
authors.lastname: Alaei
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Sharifi
authors.affiliation: Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Hosseini
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005081:Exercise Therapy / Q000379:methods*; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000534:rehabilitation*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012420:Running; D013315:Stress, Psychological / Q000150:complications / Q000534:rehabilitation*
keywords: Chronic stress; Exercise; Memory; Passive avoidance; Rat