title: Development of insecticide resistance in malaria vector Anopheles sinensis populations from Shandong province in China.
abstract: BACKGROUND
  Anopheles sinensis is a major vector of malaria and among the dominant species in Shandong province of China. Insecticide resistance is an important threat to vector-borne disease control. However, there are only few reports about insecticide resistance of An. sinensis populations from Shandong province.
  
  
  METHODS
  From 2003 to 2012, six districts in Shandong province were selected as the study areas. Insecticide susceptibility bioassay were tested on F1 progeny of An. sinensis to 4% DDT, 0.05% deltamethrin, 0.15% cyfluthrin, and 5% malathion, using the standard WHO resistance tube assay.
  
  
  RESULTS
  The resistance status of An. sinensis showed a significant decrease in the mortality rates in DDT, deltamethrin and cyfluthrin during the past ten years. Whereas obvious increase of mortality to malathion was observed throughout the assay, ranging from 47.37% to 86.62%.
authors.affiliation: Department of Medical Entomology, Shandong Institute of Parasitic Diseases, 11 Taibai Middle Road, Jining, 272033, Shandong Province, P.R. China. daiyuhua2014@126.com.|Henan Entry-exit Inspection and Quarantine Bureau of P.R.C, 269 Jinshui Road, Zhengzhou, 450003, Henan Province, P.R. China. daiyuhua2014@126.com.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Medical Entomology, Shandong Institute of Parasitic Diseases, 11 Taibai Middle Road, Jining, 272033, Shandong Province, P.R. China. hd19840502@126.com.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Huang
authors.affiliation: Department of Medical Entomology, Shandong Institute of Parasitic Diseases, 11 Taibai Middle Road, Jining, 272033, Shandong Province, P.R. China. cpzuye@aliyun.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Cheng
authors.affiliation: Department of Medical Entomology, Shandong Institute of Parasitic Diseases, 11 Taibai Middle Road, Jining, 272033, Shandong Province, P.R. China. jj8liu@sina.com.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Medical Entomology, Shandong Institute of Parasitic Diseases, 11 Taibai Middle Road, Jining, 272033, Shandong Province, P.R. China. whf9721@163.com.
authors.forename: Haifang
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Medical Entomology, Shandong Institute of Parasitic Diseases, 11 Taibai Middle Road, Jining, 272033, Shandong Province, P.R. China. whw2138@126.com.
authors.forename: Huaiwei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Medical Entomology, Shandong Institute of Parasitic Diseases, 11 Taibai Middle Road, Jining, 272033, Shandong Province, P.R. China. koujx123@163.com.
authors.forename: Jingxuan
authors.initials: J
authors.lastname: Kou
mesh_terms: D000818:Animals; D000852:Anopheles / Q000187:drug effects*; D002681:China / Q000453:epidemiology; D003634:DDT / Q000494:pharmacology; D005260:Female; D007303:Insect Vectors / Q000187:drug effects*; D007305:Insecticide Resistance; D007306:Insecticides / Q000494:pharmacology*; D008288:Malaria / Q000635:transmission*; D008294:Malathion / Q000494:pharmacology; D009570:Nitriles / Q000494:pharmacology; D011722:Pyrethrins / Q000494:pharmacology
chemical_list: D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; D003634:DDT; C052570:cyfluthrin; D008294:Malathion