title: Changes in MMP-9 and TIMP-1 Concentrations in Cerebrospinal Fluid after 1 Week of Treatment of Childhood Bacterial Meningitis.
abstract: We explored the changes of the initially highly upgraded cerebrospinal fluid matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of MMP 1 (TIMP-1) response during recovery of childhood bacterial meningitis and their association with outcome. The sizes of these changes varied substantially, but a steeper decrease in the MMP-9 and an increase of the TIMP-1 concentrations augured a better outcome.
authors.affiliation: Faculty of Medicine, Universidad Diego Portales, Santiago, Chile irmeli.roine@gmail.com.
authors.forename: Irmeli
authors.identifier: http://orcid.org/0000-0003-0020-361X
authors.initials: I
authors.lastname: Roine
authors.affiliation: Hospital Pediátrico David Bernardino, Luanda, Angola Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
authors.forename: Tuula
authors.initials: T
authors.lastname: Pelkonen
authors.affiliation: Infectious Diseases, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
authors.forename: Anneli
authors.initials: A
authors.lastname: Lauhio
authors.affiliation: Virology and Immunology, Laboratory Services (HUSLAB), Helsinki University Hospital, Helsinki, Finland.
authors.forename: Maija
authors.initials: M
authors.lastname: Lappalainen
authors.affiliation: Hospital Pediátrico David Bernardino, Luanda, Angola.
authors.forename: Manuel Leite
authors.initials: ML
authors.lastname: Cruzeiro
authors.affiliation: Hospital Pediátrico David Bernardino, Luanda, Angola.
authors.forename: Luis
authors.initials: L
authors.lastname: Bernardino
authors.affiliation: Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
authors.forename: Taina
authors.initials: T
authors.lastname: Tervahartiala
authors.affiliation: Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
authors.forename: Timo
authors.initials: T
authors.lastname: Sorsa
authors.affiliation: Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
authors.forename: Heikki
authors.initials: H
authors.lastname: Peltola
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D002675:Child, Preschool; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000134:cerebrospinal fluid*; D016920:Meningitis, Bacterial / Q000188:drug therapy* / Q000473:pathology*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000134:cerebrospinal fluid*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; C560822:TIMP1 protein, human; D019715:Tissue Inhibitor of Metalloproteinase-1; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9