title: Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR.
abstract: Hiromi Kubagawa and John E. Coligan coordinated an online meeting to define an appropriate nomenclature for the cell surface glycoprotein presently designated by different names: Toso, Fas apoptosis inhibitory molecule 3 (FAIM3), and IgM FcR (FcμR). FAIM3 and Faim3 are the currently approved symbols for the human and mouse genes, respectively, in the National Center for Biotechnology Information, Ensembl, and other databases. However, recent functional results reported by several groups of investigators strongly support a recommendation for renaming FAIM3/Faim3 as FCMR/Fcmr, a name better reflecting its physiological function as the FcR for IgM. Participants included 12 investigators involved in studying Toso/FAIM3(Faim3)/FμR, representatives from the Human Genome Nomenclature Committee (Ruth Seal) and the Mouse Genome Nomenclature Committee (Monica McAndrews), and an observer from the IgM research field (Michael Carroll). In this article, we provide a brief background of the key research on the Toso/FAIM3(Faim3)/FcμR proteins, focusing on the ligand specificity and functional activity, followed by a brief summary of discussion about adopting a single name for this molecule and its gene and a resulting recommendation for genome nomenclature committees.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294; hiromi.kubagawa@drfz.de JCOLIGAN@niaid.nih.gov.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kubagawa
authors.affiliation: Department of Pediatrics, Harvard Medical School, Boston, MA 02115;
authors.forename: Michael C
authors.initials: MC
authors.lastname: Carroll
authors.affiliation: Department of Medicine, University of Southern California School of Medicine, Los Angeles, CA 90033;
authors.forename: Chaim O
authors.initials: CO
authors.lastname: Jacob
authors.affiliation: Institute for Immunology, University of Duisburg-Essen, Essen 45147, Germany;
authors.forename: Karl S
authors.initials: KS
authors.lastname: Lang
authors.affiliation: Institute for Clinical Chemistry, Hannover Medical School, Hannover 30625, Germany;
authors.forename: Kyeong-Hee
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario M5T 2M9, Canada;
authors.forename: Tak
authors.initials: T
authors.lastname: Mak
authors.affiliation: Mouse Genome Informatics, Jackson Laboratory, Bar Harbor, ME 04609;
authors.forename: Monica
authors.initials: M
authors.lastname: McAndrews
authors.affiliation: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;
authors.forename: Herbert C
authors.initials: HC
authors.lastname: Morse
authors.affiliation: Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305;
authors.forename: Garry P
authors.initials: GP
authors.lastname: Nolan
authors.affiliation: Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan;
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohno
authors.affiliation: Kinderklinik, Klinikum Rechts der Isar, Technische Universität München, Munich 81664, Germany;
authors.forename: Günther H
authors.initials: GH
authors.lastname: Richter
authors.affiliation: Human Genome Organisation Gene Nomenclature Committee, European Bioinformatics Institute, Wellcome Trust Genome Campus Hinxton, Cambridgeshire CB10 1SD, United Kingdom;
authors.forename: Ruth
authors.initials: R
authors.lastname: Seal
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; and.
authors.forename: Ji-Yang
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: Adrian
authors.initials: A
authors.lastname: Wiestner
authors.affiliation: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852; hiromi.kubagawa@drfz.de JCOLIGAN@niaid.nih.gov.
authors.forename: John E
authors.initials: JE
authors.lastname: Coligan
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D006801:Humans; D007075:Immunoglobulin M; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D011961:Receptors, Fc / Q000145:classification; D009626:Terminology as Topic
chemical_list: D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; C112037:FCMR protein, human; C499656:Fcmr protein, mouse; D007075:Immunoglobulin M; D008565:Membrane Proteins; D011961:Receptors, Fc