title: Double blind randomized prospective trial of bethanechol in the prevention of radiation-induced salivary gland dysfunction in head and neck cancer patients.
abstract: This study assessed the prophylactic bethanechol use to prevent salivary gland dysfunction during radiotherapy. A total of 97 head and neck cancer patients were allocated into two groups: Bethanechol or Placebo. Bethanechol group presented significantly improve of salivary parameters. Bethanechol was effective in decreasing the salivary gland damage.
authors.affiliation: Stomatology Department, A.C. Camargo Cancer Center, São Paulo, Brazil.
authors.forename: Graziella Chagas
authors.initials: GC
authors.lastname: Jaguar
authors.affiliation: Nuclear Medicine Department, A.C. Camargo Cancer Center, São Paulo, Brazil.
authors.forename: Eduardo Nóbrega Pereira
authors.initials: EN
authors.lastname: Lima
authors.affiliation: Head and Neck Department, A.C. Camargo Cancer Center, São Paulo, Brazil.
authors.forename: Luiz Paulo
authors.initials: LP
authors.lastname: Kowalski
authors.affiliation: Radiotherapy Department, A.C. Camargo Cancer Center, São Paulo, Brazil.
authors.forename: Antônio Cássio
authors.initials: AC
authors.lastname: Pellizzon
authors.affiliation: Head and Neck Department, Hospital do Câncer de Barretos, São Paulo, Brazil.
authors.forename: André Lopes
authors.initials: AL
authors.lastname: Carvalho
authors.affiliation: Radiotherapy Department, A.C. Camargo Cancer Center, São Paulo, Brazil.
authors.forename: Karina Waiswol
authors.initials: KW
authors.lastname: Boccaletti
authors.affiliation: Stomatology Department, A.C. Camargo Cancer Center, São Paulo, Brazil. Electronic address: falves@accamargo.org.br.
authors.forename: Fabio Abreu
authors.initials: FA
authors.lastname: Alves
mesh_terms: D000328:Adult; D000368:Aged; D018723:Bethanechol / Q000627:therapeutic use*; D004307:Dose-Response Relationship, Radiation; D004311:Double-Blind Method; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011878:Radiotherapy / Q000009:adverse effects; D012469:Salivary Glands / Q000503:physiopathology*; D014987:Xerostomia / Q000503:physiopathology* / Q000517:prevention & control*
chemical_list: D018723:Bethanechol
keywords: Bethanechol; Intensity modulated radiation therapy; Salivary flow; Salivary glands scintigraphy; Three-dimensional radiotherapy; Xerostomia