title: Highly cross-linked polyethylene improves wear and mid-term failure rates for young total hip arthroplasty patients.
abstract: We compared clinical outcomes and polyethylene wear for 2 young primary THA patient cohorts (<50 years of age) at mid-term follow-up. In total, 72 patients (84 hips) received a coventional polyethylene liner (CPE) and 84 patients (89 hips) received a highly cross-linked polyethylene liner (HXLPE). Mean Harris Hip Score improved to 81 points for both groups. UCLA activity scores were higher for HXLPE patients (6.0 vs 5.3, p = 0.03), with lower mean linear wear (0.02 vs 0.13 mm/year, p<0.001) and lower mean volumetric wear (75.1 vs 229.8 mm3, p<0.001) at an average of 70 months follow-up. No HXLPE patient required revision for wear related concerns, compared to 5 CPE patients with revision for aseptic loosening or impending radiographic failure (0% vs 5.9%, p = 0.02). HXLPE is associated with reduced wear among young, active THA patients without increased risk of early mechanical failure.
authors.affiliation: Washington University School of Medicine, St Louis, Missouri - USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Keeney
authors.affiliation: University of Chicago, Chicago, Illinois - USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Martell
authors.affiliation: Washington University School of Medicine, St Louis, Missouri - USA.
authors.forename: Gail
authors.initials: G
authors.lastname: Pashos
authors.affiliation: Washington University School of Medicine, St Louis, Missouri - USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Nelson
authors.affiliation: Stanford University, Stanford, California - USA.
authors.forename: William J
authors.initials: WJ
authors.lastname: Maloney
authors.affiliation: Washington University School of Medicine, St Louis, Missouri - USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Clohisy
mesh_terms: D000328:Adult; D000367:Age Factors; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects* / Q000379:methods; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D020959:Polyethylene / Q000737:chemistry*; D011474:Prosthesis Design / Q000379:methods*; D011475:Prosthesis Failure; D012042:Registries; D012086:Reoperation / Q000379:methods; D012189:Retrospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric
chemical_list: D020959:Polyethylene