title: Influence of backbone conformational rigidity in temperature-sensitive amphiphilic supramolecular assemblies.
abstract: Molecular design features that endow amphiphilic supramolecular assemblies with a unique temperature-sensitive transition have been investigated. We find that conformational rigidity in the backbone is an important feature for eliciting this feature. We also find that intramolecular hydrogen-bonding can induce such rigidity in amphiphile backbone. Guest encapsulation stability of these assemblies was found to be significantly altered within a narrow temperature window, which correlates with the temperature-sensitive size transition of the molecular assembly. Molecular design principles demonstrated here could have broad implications in developing future temperature-responsive systems.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.
authors.forename: Krishna R
authors.initials: KR
authors.lastname: Raghupathi
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.
authors.forename: Uma
authors.initials: U
authors.lastname: Sridhar
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.
authors.forename: Kevin
authors.initials: K
authors.lastname: Byrne
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.
authors.forename: Kishore
authors.initials: K
authors.lastname: Raghupathi
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.
authors.forename: S
authors.initials: S
authors.lastname: Thayumanavan
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry*; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D013501:Surface-Active Agents / Q000737:chemistry*; D013696:Temperature; D044366:Transition Temperature
chemical_list: D003692:Delayed-Action Preparations; D013501:Surface-Active Agents