title: Gender differences in the hepatic elimination and pharmacokinetics of lobeglitazone in rats.
abstract: The pharmacokinetics of lobeglitazone (LB) was studied after intravenous administration at a dose of 1 mg/kg and oral administration at doses of 0.1, 1 and 10 mg/kg in male and female rats. The area under the plasma concentration-time curve from time zero to infinity (AUCinf) after intravenous administration was approximately 7.1 times higher in female rats than in male rats. In addition, the AUCinfin the case of oral administration was at least 4.4 times higher in female rats and appeared to increase in proportion to the dose in both genders. The in vitro half-lives were 18.8 ± 4.45 min and 60.7 ± 11.2 min, as evidenced by incubating liver microsomes obtained from male and female rats, respectively. As a result, the estimated CLintfor LB for male rat liver microsomes (0.0779 ± 0.0233 ml/min/mg protein) was much higher than that for female rat liver microsomes (0.0233 ± 0.0039 ml/min/mg protein, p < 0.05). These observations suggest that there are gender differences in the pharmacokinetics and hepatic metabolism for LB in rats. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea.|Korea Institute of Toxicology, 141 Gajeong-ro, Yuseong-gu, Daejeon, 305-343, Republic of Korea.
authors.forename: Jong-Hwa
authors.initials: JH
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea.
authors.forename: Jun-Hyeng
authors.initials: JH
authors.lastname: Son
authors.affiliation: Chong Kun Dang Research Institute, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si, Gyeonggi-do, 446-916, Republic of Korea.
authors.forename: Yoon-Jee
authors.initials: YJ
authors.lastname: Chae
authors.affiliation: College of Pharmacy, Kangwon National University, 1 Kangwondaehak-ro, Chuncheon, Kangwon-do, 200-701, Republic of Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Ahn
authors.affiliation: College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea.
authors.forename: Wooin
authors.initials: W
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea.
authors.forename: Dae-Duk
authors.initials: DD
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea.
authors.forename: Suk-Jae
authors.initials: SJ
authors.lastname: Chung
keywords: gender difference; hepatic elimination; lobeglitazone; pharmacokinetics; rats