title: The nuclear IκB family of proteins controls gene regulation and immune homeostasis.
abstract: The inhibitory IκB family of proteins is subdivided into two groups based on protein localization in the cytoplasm or in the nucleus. These proteins interact with NF-κB, a major transcription factor regulating the expression of many inflammatory cytokines, by modulating its transcriptional activity. However, nuclear IκB family proteins not only interact with NF-κB to change its transcriptional activity, but they also bind to chromatin and control gene expression. This review provides an overview of nuclear IκB family proteins and their role in immune homeostasis.
authors.affiliation: Laboratory of Cell Recognition and Response, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan; School of Medicine Gifu University, Gifu 501-1194, Japan. Electronic address: ta-maru@umin.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: MaruYama
mesh_terms: D000818:Animals; D000081242:B-Cell Lymphoma 3 Protein; D005786:Gene Expression Regulation / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D020672:I-kappa B Proteins / Q000235:genetics* / Q000276:immunology*; D011518:Proto-Oncogene Proteins / Q000276:immunology; D014157:Transcription Factors / Q000276:immunology
chemical_list: D000081242:B-Cell Lymphoma 3 Protein; C000631344:BCL3 protein, human; D020672:I-kappa B Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors
keywords: Gene regulation; Immune homeostasis; NF-κB; Nuclear IκB family proteins; Transcriptional factor