title: Clinical significance of serum triglyceride elevation at early stage of acute biliary pancreatitis.
abstract: BACKGROUND
  Pancreatitis induced by hypertriglyceridemia (HTG) has gained much attention. However, very limited numbers of studies have focused on the clinical significance of TG elevation in non-HTG induced pancreatitis, such as acute biliary pancreatitis (ABP). This study aimed to study the clinical significances of triglyceride (TG) elevation in patients with ABP.
  
  
  METHODS
  We retrospectively analyzed a total of 426 ABP cases in our research center. According to the highest TG level within 72 h of disease onset, the patients were divided into a normal TG group and an elevated TG group. We analyzed the differences between the two groups of patients in aspects such as general information, disease severity, APACHE II (acute physiology and chronic health evaluation II) and Ranson scores, inflammatory cytokines, complications and prognosis.
  
  
  RESULTS
  Compared with the normal TG group, patients in the elevated TG group showed a significantly higher body mass index and were significantly younger. TG elevation at the early stage of ABP was associated with higher risk of severe pancreatitis and organ failures, especially respiratory failure. For patients with severe pancreatitis, those with elevated TG levels were more likely to have a larger area of necrosis, and higher incidence of pancreatic abscess as well as higher mortality (17.78% versus 9.80%, P < 0.05).
  
  
  CONCLUSIONS
  In ABP patients, TG elevation might participate in the aggravation of pancreatitis and the occurrence of systemic or local complications. Thus, the TG level may serve as an important indicator to determine the prognosis of patients with ABP.
authors.affiliation: Department of General Surgery, Chengdu Military General Hospital, Jinniu District, Chengdu, Sichuan Province, PR China, 610083. tmmulong@163.com.
authors.forename: Long
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of General Surgery, Chengdu Military General Hospital, Jinniu District, Chengdu, Sichuan Province, PR China, 610083. lzl810130@163.com.
authors.forename: Zhulin
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Department of General Surgery, Chengdu Military General Hospital, Jinniu District, Chengdu, Sichuan Province, PR China, 610083. 18148914@qq.com.
authors.forename: Ke
authors.initials: K
authors.lastname: Xiang
authors.affiliation: Department of Pharmacy, Chengdu Military General Hospital, Chengdu, Sichuan Province, People's Republic of China. keanrjd@126.com.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of General Surgery, Chengdu Military General Hospital, Jinniu District, Chengdu, Sichuan Province, PR China, 610083. 63135482@qq.com.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of General Surgery, Chengdu Military General Hospital, Jinniu District, Chengdu, Sichuan Province, PR China, 610083. whjtlj1251@163.com.
authors.forename: Lijun
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of General Surgery, Chengdu Military General Hospital, Jinniu District, Chengdu, Sichuan Province, PR China, 610083. tfz3006101@163.com.
authors.forename: Fuzhou
authors.initials: F
authors.lastname: Tian
mesh_terms: D018806:APACHE; D018784:Abdominal Abscess / Q000097:blood*; D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D001646:Bile; D015992:Body Mass Index; D005260:Female; D042882:Gallstones / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000097:blood; D010179:Pancreas / Q000473:pathology*; D010195:Pancreatitis / Q000097:blood* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D012131:Respiratory Insufficiency / Q000097:blood; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides