title: Mild Cognitive Impairment is Associated With White Matter Integrity Changes in Late-Myelinating Regions Within the Corpus Callosum.
abstract: Degenerative brain changes in Alzheimer's disease may occur in reverse order of normal brain development based on the retrogenesis model. This study tested whether evidence of reverse myelination was observed in mild cognitive impairment (MCI) using a data-driven analytic approach based on life span developmental data. Whole-brain high-resolution diffusion tensor imaging scans were obtained for 31 patients with MCI and 79 demographically matched healthy older adults. Comparisons across corpus callosum (CC) regions of interest (ROIs) showed decreased fractional anisotropy (FA) in the body but not in the genu or splenium; early-, middle-, and late-myelinating ROIs restricted to the CC revealed decreased FA in late- but not early- or middle-myelinating ROIs. Voxelwise group differences revealed areas of lower FA in MCI, but whole-brain differences were equally distributed across early-, middle-, and late-myelinating regions. Overall, results within the CC support the retrogenesis model, although caution is needed when generalizing these results beyond the CC.
authors.affiliation: Psychology Service, VA Boston Healthcare System, Boston, MA, USA Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA nikki.stricker@va.gov.
authors.forename: Nikki H
authors.initials: NH
authors.lastname: Stricker
authors.affiliation: Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA Department of Radiology, Harvard Medical School, Boston, MA, USA Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: David H
authors.initials: DH
authors.lastname: Salat
authors.affiliation: Psychology Service, VA Boston Healthcare System, Boston, MA, USA.
authors.forename: Taylor P
authors.initials: TP
authors.lastname: Kuhn
authors.affiliation: Psychology Service, VA Boston Healthcare System, Boston, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Foley
authors.affiliation: Department of Psychiatry, Harvard Medical School, Boston, MA, USA McLean Hospital, Belmont, MA, USA.
authors.forename: Jenessa S
authors.initials: JS
authors.lastname: Price
authors.affiliation: Division of Mental Health and Addiction, KG Jebsen Centre for Psychosis Research, Norwegian Centre for Mental Disorder Research (NORMENT), Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway Department of Psychology, University of Oslo, Oslo, Norway.
authors.forename: Lars T
authors.initials: LT
authors.lastname: Westlye
authors.affiliation: Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Esterman
authors.affiliation: Department of Psychiatry, Harvard Medical School, Boston, MA, USA Geriatric Research, Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA.
authors.forename: Regina E
authors.initials: RE
authors.lastname: McGlinchey
authors.affiliation: Department of Psychiatry, Harvard Medical School, Boston, MA, USA Geriatric Research, Education and Clinical Center (GRECC), VA Boston Healthcare System, Boston, MA, USA.
authors.forename: William P
authors.initials: WP
authors.lastname: Milberg
authors.affiliation: Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA Department of Medicine, Harvard Medical School, Boston, MA, USA.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Leritz
mesh_terms: D000328:Adult; D000368:Aged; D016880:Anisotropy; D001921:Brain / Q000473:pathology; D060825:Cognitive Dysfunction / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000473:pathology; D009483:Neuropsychological Tests; D066127:White Matter / Q000473:pathology*
keywords: Alzheimer’s disease; corpus callosum; diffusion tensor imaging; magnetic resonance imaging; mild cognitive impairment