title: Global spectrum of copy number variations reveals genome organizational plasticity and proposes new migration routes.
abstract: Global spectrum of CNVs is required to catalog variations to provide a high-resolution on the dynamics of genome-organization and human migration. In this study, we performed genome-wide genotyping using high-resolution arrays and identified 44,109 CNVs from 1,715 genomes across 12 populations. The study unraveled the force of independent evolutionary dynamics on genome-organizational plasticity across populations. We demonstrated the use of CNV tool to study human migration and identified a second major settlement establishing new migration routes in addition to existing ones.
authors.affiliation: Genetics and Genomics Lab, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-06, Karnataka, India.
authors.forename: Avinash M
authors.initials: AM
authors.lastname: Veerappa
authors.affiliation: Genetics and Genomics Lab, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-06, Karnataka, India.
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Vishweswaraiah
authors.affiliation: Genetics and Genomics Lab, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-06, Karnataka, India.
authors.forename: Kusuma
authors.initials: K
authors.lastname: Lingaiah
authors.affiliation: Genetics and Genomics Lab, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-06, Karnataka, India.
authors.forename: Megha
authors.initials: M
authors.lastname: Murthy
authors.affiliation: Genetics and Genomics Lab, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-06, Karnataka, India.
authors.forename: Raviraj V
authors.initials: RV
authors.lastname: Suresh
authors.affiliation: NUCSER, KS Hegde Medical Academy, Nitte University, Mangalore-18, Karnataka, India.
authors.forename: Dinesh S
authors.initials: DS
authors.lastname: Manjegowda
authors.affiliation: Genetics and Genomics Lab, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-06, Karnataka, India.
authors.forename: Nallur B
authors.initials: NB
authors.lastname: Ramachandra
mesh_terms: D000483:Alleles; D056905:Chromosome Breakpoints; D002872:Chromosome Deletion; D058674:Chromosome Duplication; D019295:Computational Biology / Q000379:methods; D056915:DNA Copy Number Variations; D019143:Evolution, Molecular; D005787:Gene Frequency; D005828:Genetics, Population; D015894:Genome, Human; D055106:Genome-Wide Association Study; D023281:Genomics; D063426:Human Migration; D006801:Humans; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D015203:Reproducibility of Results