title: [Efficiency of meldonium in the complex therapy of acute coronary syndrome].
abstract: We examined 140 patients (mean age 54.8±3.1 years) with ST elevation acute coronary syndrome resulting in Q-wave myocardial infarction of the left ventricle. From the first hours complex therapy of these patients comprised meldonium (1 g/day intravenously for 2 weeks then orally until 1.5 months). Therapy with meldonium accelerated restoration of left ventricular diastolic function what was in agreement with lowering of NT-proBNT concentration in blood. It was established that administration of meldonium led to reduction of number of high grade ventricular extrasystoles during first 6 hours after thrombolysis, to lowering of blood concentration of lipoperoxide degradation products. Early use of meldonium decreases probability of emergence of fatal arrhythmias and improves prognosis of hospital stage of rehabilitation of patients with acute coronary syndrome resulting in Q-wave myocardial infarction.
authors.forename: V P
authors.initials: VP
authors.lastname: Mikhin
authors.forename: M A
authors.initials: MA
authors.lastname: Cherniatina
authors.forename: G V
authors.initials: GV
authors.lastname: Panchenko
authors.forename: A V
authors.initials: AV
authors.lastname: Kharchenko
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Tsukanova
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000009:adverse effects; D017023:Coronary Angiography / Q000379:methods; D003971:Diastole / Q000187:drug effects*; D004333:Drug Administration Routes; D016903:Drug Monitoring; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008763:Methylhydrazines / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D002317:Cardiovascular Agents; D008763:Methylhydrazines; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; C050147:3-(2,2,2-trimethylhydrazine)propionate