title: Monitoring coagulation proteins during progression of liver disease.
abstract: This work was designated to monitor the coagulation abnormalities associated with the gradual progression of liver diseases. The study included fifty patients; forty were diagnosed with liver cirrhosis with different stages categorized according to the Childs-Pugh classification and another ten patients were diagnosed with hepatocellular carcinoma (HCC). Haemostatic variables including fibrinogen (FI), calcium (FIV), transglutaminase (FXIII), prothrombin time (PT) and platelet count were estimated in patients and compared with the baseline levels of healthy subjects (n = 10). The results demonstrated that the fibrinogen level was progressively decreased, whereas PT was progressively prolonged in Child A, Child B and Child C groups. The maximum deterioration was observed in HCC patients. Calcium significantly increased in mild (Child A) and moderate (Child B) but not in Child C cirrhosis and HCC patients. FXIII level did not show any significant changes in cirrhotic patients compared to healthy group. Some of the haemostatic variables we investigated were correlated with serum albumin and bilirubin but not with aminotransferases (ALT and AST). The results indicated that the haemostatic abnormalities in fibrinogen, calcium and PT (but not FXIII) were deteriorated in parallel with the gradual regression of the constitutional function of liver.
authors.affiliation: Department of Chemistry, Division of Biochemistry, Faculty of Science, Tanta University, Tanta, Egypt ; Department of Clinical Biochemistry, College of Medicine, KKU, Abha, Kingdom of Saudi Arabia.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hessien
authors.affiliation: Department of Chemistry, Division of Biochemistry, Faculty of Science, Tanta University, Tanta, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ayad
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt.
authors.forename: Wafaa M
authors.initials: WM
authors.lastname: Ibrahim
authors.affiliation: Department of Chemistry, Division of Biochemistry, Faculty of Science, Tanta University, Tanta, Egypt.
authors.forename: Batoul Izz
authors.initials: BI
authors.lastname: ulArab
keywords: Coagulation factors; FIV; FXIII; Fibrinogen; HCC; Liver cirrhosis; Prothrombin time