title: MicroRNA-126 inhibits the proliferation of lung cancer cell line A549.
abstract: OBJECTIVE
  To study the role of microRNA-126 in the development of lung cancer.
  
  
  METHODS
  The biological function of microRNA-126 was detected using EdU assay and CCK-8 assay; the target gene of microRNA-126 was analyzed using real time RT-PCR and Western blot assay.
  
  
  RESULTS
  In A549 cell line, overexpression of microRNA-126 inhibits the proliferation rate; VEGF is the target gene of microRNA-126; microRNA-126 exerts its function via regulating VEGF protein level.
  
  
  CONCLUSIONS
  microRNA-126 inhibits the proliferation in A549 cell line.
authors.affiliation: Respiratory Department, Central Hospital of Wuhan, Wuhan 430014, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Yang
authors.affiliation: Respiratory Department, Central Hospital of Wuhan, Wuhan 430014, China.
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Chen
authors.affiliation: Respiratory Department, Central Hospital of Wuhan, Wuhan 430014, China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Zhang
authors.affiliation: Respiratory Department, Central Hospital of Wuhan, Wuhan 430014, China. Electronic address: 1844209009@qq.com.
authors.forename: Xin-Rong
authors.initials: XR
authors.lastname: Wang
keywords: Proliferation; VEGF; microRNA–126