title: Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection.
abstract: The therapeutic efficacies of smallpox vaccine ACAM2000 and antiviral tecovirimat given alone or in combination starting on day 3 postinfection were compared in a cynomolgus macaque model of lethal monkeypox virus infection. Postexposure administration of ACAM2000 alone did not provide any protection against severe monkeypox disease or mortality. In contrast, postexposure treatment with tecovirimat alone or in combination with ACAM2000 provided full protection. Additionally, tecovirimat treatment delayed until day 4, 5, or 6 postinfection was 83% (days 4 and 5) or 50% (day 6) effective.
authors.affiliation: SIGA Technologies, Inc., Corvallis, Oregon, USA aberhanu@Siga.com.
authors.forename: Aklile
authors.initials: A
authors.lastname: Berhanu
authors.affiliation: Southern Research Institute, Frederick, Maryland, USA.
authors.forename: Jonathan T
authors.initials: JT
authors.lastname: Prigge
authors.affiliation: Southern Research Institute, Frederick, Maryland, USA.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Silvera
authors.affiliation: SIGA Technologies, Inc., Corvallis, Oregon, USA.
authors.forename: Kady M
authors.initials: KM
authors.lastname: Honeychurch
authors.affiliation: SIGA Technologies, Inc., Corvallis, Oregon, USA.
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Hruby
authors.affiliation: SIGA Technologies, Inc., Corvallis, Oregon, USA.
authors.forename: Douglas W
authors.initials: DW
authors.lastname: Grosenbach
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D003131:Combined Modality Therapy; D054833:Isoindoles / Q000627:therapeutic use*; D007958:Leukocyte Count; D008252:Macaca fascicularis; D045908:Mpox, Monkeypox / Q000188:drug therapy* / Q000401:mortality / Q000821:virology; D008993:Monkeypox virus / Q000276:immunology; D012899:Smallpox / Q000188:drug therapy*; D012900:Smallpox Vaccine / Q000627:therapeutic use*; D014611:Vaccination; D019562:Viral Load / Q000187:drug effects; D014765:Viral Vaccines / Q000627:therapeutic use*; D010797:Phthalimides
chemical_list: D000998:Antiviral Agents; D001549:Benzamides; D054833:Isoindoles; D012900:Smallpox Vaccine; D014765:Viral Vaccines; C000588544:ACAM2000; C505045:tecovirimat; D010797:Phthalimides