title: Interleukin-17 in systemic lupus erythematosus: A comprehensive review.
abstract: Systemic lupus erythematosus (SLE) is a complicated autoimmune disease of multifactorial pathoaetiology. One of the most serious manifestations is lupus nephritis. The pathogenesis of SLE has not been well elucidated, but it has been reported that interleukin-17 (IL-17) and Th17 cells play important roles in the pathogenesis of SLE. IL-17A, a member of IL-17 family, amplifies the immune response by inducing the local production of chemokines and cytokines, recruiting neutrophils and monocytes, augmenting the production of autoantibodies, and aggravating the inflammation and damage of target organs such as the kidney in SLE. In recent years, several IL-17A pathway inhibitors have advanced into clinical trials, including the anti-IL-17A monoclonal antibody and the anti-17RA monoclonal antibody. Several agents have shown great success in Phase II trials in multiple autoimmune diseases such as psoriasis, rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, and non-infectious uveitis, which has sparked the urgent need of anti-IL-17A as innovative therapeutic option in controlling disease activity of moderate-to-severe SLE. Here, we review and summarize current progress in IL-17A and SLE from in vitro studies, human expression studies, and animal models, providing novel insight into its therapeutic potential.
authors.affiliation: a Department of Dermatology , Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics , Changsha , China .
authors.forename: Duo
authors.initials: D
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Guo
authors.forename: Haijing
authors.initials: H
authors.lastname: Wu
authors.forename: Lina
authors.initials: L
authors.lastname: Tan
authors.forename: Christopher
authors.initials: C
authors.lastname: Chang
authors.forename: Qianjin
authors.initials: Q
authors.lastname: Lu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D002450:Cell Communication; D002454:Cell Differentiation; D044127:Epigenesis, Genetic; D015870:Gene Expression; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use; D056747:Immunomodulation; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D015398:Signal Transduction / Q000187:drug effects; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D007155:Immunologic Factors; D020381:Interleukin-17
keywords: Anti-IL17 agents; Th17 cell; immune tolerance; interleukin-17; lupus nephritis; systemic lupus erythematosus