title: Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens.
abstract: In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.
authors.affiliation: Department of Biotechnology, Middle East Technical University, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kavruk
authors.forename: O
authors.initials: O
authors.lastname: Celikbicak
authors.forename: V C
authors.initials: VC
authors.lastname: Ozalp
authors.forename: B A
authors.initials: BA
authors.lastname: Borsa
authors.forename: F J
authors.initials: FJ
authors.lastname: Hernandez
authors.forename: G
authors.initials: G
authors.lastname: Bayramoglu
authors.forename: B
authors.initials: B
authors.lastname: Salih
authors.forename: M Y
authors.initials: MY
authors.lastname: Arica
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development; D014640:Vancomycin / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D052157:Aptamers, Nucleotide; D053769:Nanocapsules; D014640:Vancomycin