title: Living-donor kidney transplant from hepatitis B surface antigen-positive donors to hepatitis B antibody-positive recipients without hepatitis B immunoglobulin prophylaxis in an endemic country.
abstract: OBJECTIVE
  Living-donor kidney transplant from donors who are chronically infected with hepatitis B virus can be considered as a possibility to compensate for insufficiency of organ transplants, particularly in a hepatitis B virus endemic country. In this study, the safety and efficacy were reviewed retrospectively in living-donor kidney transplant from donors who were chronically infected with hepatitis B virus.
  
  
  METHODS
  In the years between 2012 and 2013, we transplanted 4 renal grafts from hepatitis B surface antigen-positive living donors to antihepatitis B antibody-positive recipients. Lamivudine was prescribed for recipients after transplant without hepatitis B immunoglobulin.
  
  
  RESULTS
  In 1-year follow-up, there were no abnormal findings in the levels of renal and liver enzymes, and there was no unwanted seroconversion to positive hepatitis B surface antigen.
  
  
  CONCLUSIONS
  When combined with careful hepatitis B virus-monitoring, renal grafts from hepatitis B surface antigen-positive living donors can be transplanted to hepatitis B antibody-positive recipients, without the need for hepatitis B immunoglobulin prophylaxis, in a hepatitis B virus endemic country.
authors.affiliation: From the Department of Surgery, Korea University Anam Hospital, Seoul, Korea.
authors.forename: Heungman
authors.initials: H
authors.lastname: Jun
authors.forename: Myung Gyu
authors.initials: MG
authors.lastname: Kim
authors.forename: Kwan Tae
authors.initials: KT
authors.lastname: Park
authors.forename: Cheol Woong
authors.initials: CW
authors.lastname: Jung
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D019353:Endemic Diseases; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D066027:Transplant Recipients; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D007136:Immunoglobulins; C045213:hepatitis B hyperimmune globulin