title: Association between the CX3CR1 gene V249I polymorphism and delayed kidney allograft function.
abstract: BACKGROUND
  Fractalkine is a member of the chemokine family that acts as an adhesion molecule and as an extracellular chemoattractant promoting cellular migration. In this study, we analysed the association between the CX3CR1 gene V249I (rs3732379) SNP and renal allograft function.
  
  
  METHODS
  The study enrolled 270 Caucasian kidney allograft recipients. The following parameters were recorded in each case: the recipient's age and gender, delayed graft function (DGF) defined as the need for dialysis in the first 7 days after transplantation, occurrence and number of episodes of acute rejection (AR), and chronic allograft dysfunction (CAD).
  
  
  RESULTS
  Delayed graft function was diagnosed in 39.2% of individuals with the CC genotype, 22.7% with CT and 23.5% of those with the TT genotype. The differences were statistically significant (CC vs. TT+CT: OR = 2.17; 95% CI = 1.28-3.70, p = 0.0042). In multivariate analysis the CC genotype was an independent and significant predictor of higher risk of DGF. The distribution of genotypes and alleles of the CX3CR1 gene polymorphism among patients with and without AR as well as CAD did not differ significantly.
  
  
  CONCLUSIONS
  The results of this study suggest that the CX3CR1 gene V249I (rs3732379) SNP CC genotype is associated with increased risk of DGF.
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Dabrowska-Zamojcin
authors.affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
authors.forename: Violetta
authors.initials: V
authors.lastname: Dziedziejko
authors.affiliation: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Safranow
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Kurzawski
authors.affiliation: Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
authors.forename: Leszek
authors.initials: L
authors.lastname: Domanski
authors.affiliation: Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland. Electronic address: pawand@poczta.onet.pl.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
mesh_terms: D000208:Acute Disease; D000328:Adult; D064591:Allografts / Q000276:immunology / Q000378:metabolism*; D000073883:CX3C Chemokine Receptor 1; D002448:Cell Adhesion / Q000235:genetics; D004252:DNA Mutational Analysis; D051799:Delayed Graft Function / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006084:Graft Rejection / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide; D019707:Receptors, Chemokine / Q000235:genetics*; D012306:Risk
chemical_list: D000073883:CX3C Chemokine Receptor 1; C095235:CX3CR1 protein, human; D019707:Receptors, Chemokine
keywords: Delayed graft function; Fractalkine; Graft; Kidney