title: Treatment of atopic dermatitis with KAM-3008, a barrier-based, non-steroidal topical cream.
abstract: BACKGROUND
  Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyper-reactivity to environmental triggers, and is characterized by pruritic eczematous skin lesions. Recent insights into the pathophysiology of AD point to the important role that abnormal barrier permeability plays, which leads to compromised hydration, common micro-organismal colonization and immune dysregulation. Current treatment strategies for AD, such as topical corticosteroids and moisturizers, control the disease symptom's severity and duration. KAM-3008 is a novel, barrier-based, steroid-free, topical cream indicated for the relief of symptoms associated with AD. In addition to moisturizing and emollient ingredients, several herbal extracts have been incorporated into the formulation to enhance its anti-allergic and anti-inflammatory properties.
  
  
  METHODS
  In this study, the safety and efficacy of KAM-3008 body cream in relieving the symptoms of AD in adult subjects after 7, 14 and 21 days of treatment were investigated using the transepidermal water loss (TEWL), skin hydration and scoring atopic dermatitis (SCORAD) measurements.
  
  
  CONCLUSIONS
  Based on both the quantitative TEWL and qualitative SCORAD assessments, we found that KAM-3008 body cream is a safe, well-tolerated and efficacious stand-alone treatment for the relief of AD symptoms.
authors.affiliation: a Kamedis Ltd. , Tel Aviv , Israel.
authors.forename: Yonit
authors.initials: Y
authors.lastname: Bomstein
authors.affiliation: a Kamedis Ltd. , Tel Aviv , Israel.
authors.forename: Sharon
authors.initials: S
authors.lastname: Rozenblat
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D000975:Antioxidants; D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004485:Eczema / Q000188:drug therapy; D004643:Emollients / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy; D013256:Steroids; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D003879:Dermatologic Agents; D004643:Emollients; D010936:Plant Extracts; D013256:Steroids
keywords: Anti-allergic; SCORAD; anti-oxidant; atopic dermatitis; eczema; herbal extracts; transepidermal water loss