title: (68)Ga-DOTANOC PET/CT detection of multiple extracranial localizations in a patient with anaplastic meningioma.
abstract: We report herein a case of a 65-year-old male with intracranial recurrence of atypical meningioma initially treated with a combination of surgical resection and gamma knife radiotherapy. Afterwards, he underwent a (68)Ga-DOTANOC PET/CT scan in order to evaluate the feasibility of peptide receptor radionuclide therapy (PRRT). The scan identified multiple pulmonary, pleural and lymph node localizations. Histological diagnosis was consistent with intracranial atypical meningioma with diffuse metastatic spread. In our case, we have shown that meningioma with extracranial locations may present high uptake of somatostatin receptor analogues. Among other radionuclides, we believe that (68)Ga-DOTANOC PET/CT may be particularly useful for staging, detection of recurrence, evaluation of disease extension and alternative therapeutic approaches.
authors.affiliation: Division of Nuclear Medicine, Central Hospital, Bolzano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Golemi
authors.affiliation: Division of Pathology, Central Hospital, Bolzano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ambrosini
authors.affiliation: Division of Neurosurgery, Central Hospital, Bolzano, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Cecchi
authors.affiliation: Division of Radiology, Central Hospital, Bolzano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ruiu
authors.affiliation: Department of Nuclear Medicine & PET/CT Centre, Santa Maria della Misericordia Hospital, Rovigo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Chondrogiannis
authors.affiliation: Division of Nuclear Medicine, Central Hospital, Bolzano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Farsad
authors.affiliation: Department of Nuclear Medicine & PET/CT Centre, Santa Maria della Misericordia Hospital, Rovigo, Italy. Electronic address: rubello.domenico@azisanrovigo.it.
authors.forename: D
authors.initials: D
authors.lastname: Rubello
mesh_terms: D000368:Aged; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging* / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D009363:Neoplasm Proteins / Q000032:analysis*; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D009367:Neoplasm Staging / Q000379:methods; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging*; D000072078:Positron Emission Tomography Computed Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D016634:Radiosurgery; D017481:Receptors, Somatostatin / Q000032:analysis*
chemical_list: C504894:68Ga-DOTANOC; D005710:Gallium Radioisotopes; D009363:Neoplasm Proteins; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D017481:Receptors, Somatostatin
keywords: (68)Ga-DOTANOC PET/CT; (68)Ga-DOTANOC PET/TC; Atypical meningioma; Distant localizations; Localizaciones distantes; Meningioma atípico