title: Moderating Effects of Genetic Polymorphisms on Improvements in Cognitive Impairment in Breast Cancer Survivors Participating in a 6-Week Mindfulness-Based Stress Reduction Program.
abstract: Breast cancer (BC) survivors often report cognitive impairment, which may be influenced by single-nucleotide polymorphisms (SNPs). The purpose of this study was to test whether particular SNPs were associated with changes in cognitive function in BC survivors and whether these polymorphisms moderated cognitive improvement resulting from the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program. BC survivors recruited from Moffitt Cancer Center and the University of South Florida's Breast Health Program, who had completed adjuvant radiation and/or chemotherapy treatment, were randomized to either the 6-week MBSR(BC) program (n = 37) or usual care (UC; n = 35) group. Measures of cognitive function and demographic and clinical history data were attained at baseline and at 6 and 12 weeks. A total of 10 SNPs from eight genes known to be related to cognitive function were analyzed using blood samples. Results showed that SNPs in four genes (ankyrin repeat and kinase domain containing 1 [ANKK1], apolipoprotein E [APOE], methylenetetrahydrofolate reductase [MTHFR], and solute carrier family 6 member 4 [SLC6A4]) were associated with cognitive impairment. Further, rs1800497 in ANKK1 was significantly associated with improvements in cognitive impairment in response to MBSR(BC). These results may help to identify individuals who would be better served by MBSR(BC) or other interventions.
authors.affiliation: College of Nursing, University of South Florida, Tampa, FL, USA Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA clengach@health.usf.edu.
authors.forename: Cecile A
authors.initials: CA
authors.lastname: Lengacher
authors.affiliation: College of Arts and Sciences, University of South Florida Sarasota-Manatee, Sarasota, FL, USA Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Richard R
authors.initials: RR
authors.lastname: Reich
authors.affiliation: College of Nursing, University of South Florida, Tampa, FL, USA.
authors.forename: Kevin E
authors.initials: KE
authors.lastname: Kip
authors.affiliation: College of Nursing, University of South Florida, Tampa, FL, USA.
authors.forename: Carly L
authors.initials: CL
authors.lastname: Paterson
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Hyun Y
authors.initials: HY
authors.lastname: Park
authors.affiliation: College of Nursing, University of South Florida, Tampa, FL, USA.
authors.forename: Sophia
authors.initials: S
authors.lastname: Ramesar
authors.affiliation: Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Heather S L
authors.initials: HS
authors.lastname: Jim
authors.affiliation: College of Nursing, University of South Florida, Tampa, FL, USA.
authors.forename: Carissa B
authors.initials: CB
authors.lastname: Alinat
authors.affiliation: Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
authors.forename: Jong Y
authors.initials: JY
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000235:genetics / Q000523:psychology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D064866:Mindfulness; D011110:Polymorphism, Genetic; D013315:Stress, Psychological / Q000235:genetics / Q000523:psychology*; D017741:Survivors / Q000523:psychology*; D016896:Treatment Outcome
keywords: MBSR(BC); breast cancer; cognitive function; genetic polymorphism; genetics; mindfulness-based stress reduction