title: [Prophylactic antibiotics: a necessity in totally percutaneous thoracic endovascular aortic repair?].
abstract: OBJECTIVE
  To study the benefit of prophylactic antibiotics (PA) in totally percutaneous aortic endovascular repair (PEVAR) in the catheterization laboratory for reducing stent-graft infection and postimplantation syndrome (PIS).
  
  
  METHODS
  The clinical data were analyzed of patients undergoing thoracic endovascular aortic repairs. The patients were divided into non-PA group and PA group according to the use of prophylactic antibiotics before PEVAR. The diagnosis of infection was made by two senior physicians with reference to Hospital Acquired Infection Diagnostic Criteria Assessment released by the Ministry of Health of China.
  
  
  RESULTS
  The 95 enrolled patients included 35 with PA and 60 without PA group, who were comparable for baseline characteristics. Infection-related deaths occurred in 1 case in non-PA group and retrograde Stanford type A dissection and death occurred in 1 case in PA group (1.67% vs 2.85%, P=1.00). The PA and non-PA groups showed no significant difference in the incidence of postoperative infection (5% vs 2.86%, P=1.000), hospital stay (9.30±7.21 vs 10.06±5.69, P=0.094), infection-related mortality (1.67% vs 0%, P=1.00), or postoperative fever (70.90% vs 91.43%, P=0.20). The body temperature showed significant variations at different time points after procedure (F=19.831, P<0.001) irrelevant to the use of prophylactic antibiotics (F=0.978, P=0.326).
  
  
  CONCLUSIONS
  The current data do not support the benefit of PA in reducing postoperative infection and PIS in patients undergoing PEVAR, but the patients without PA may have worse clinical outcomes in the event of postoperative infections.
authors.affiliation: Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Acedamy of Medical Sciences, Guangzhou 510100, China. E-mail: xnj-mm@163.com.
authors.forename: Nian-Jin
authors.initials: NJ
authors.lastname: Xie
authors.forename: Song-Yuan
authors.initials: SY
authors.lastname: Luo
authors.forename: Ling
authors.initials: L
authors.lastname: Xue
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Meng-Nan
authors.initials: MN
authors.lastname: Gu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Huang
authors.forename: Rui-Xin
authors.initials: RX
authors.lastname: Fan
authors.forename: Ji-Yan
authors.initials: JY
authors.lastname: Hen
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Luo
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis; D001013:Aorta, Thoracic / Q000601:surgery*; D002681:China; D057510:Endovascular Procedures; D006801:Humans; D007902:Length of Stay; D011183:Postoperative Complications / Q000517:prevention & control*; D015607:Stents; D014656:Vascular Surgical Procedures
chemical_list: D000900:Anti-Bacterial Agents