title: Landscape of post-transcriptional gene regulation during hepatitis C virus infection.
abstract: Post-transcriptional regulation of gene expression plays a pivotal role in various gene regulatory networks including, but not limited to metabolism, embryogenesis and immune responses. Different mechanisms of post-transcriptional regulation, which can act individually, synergistically, or even in an antagonistic manner have been described. Hepatitis C virus (HCV) is notorious for subverting host immune responses and indeed exploits several components of the host's post-transcriptional regulatory machinery for its own benefit. At the same time, HCV replication is post-transcriptionally targeted by host cell components to blunt viral propagation. This review discusses the interplay of post-transcriptional mechanisms that affect host immune responses in the setting of HCV infection and highlights the sophisticated mechanisms both host and virus have evolved in the race for superiority.
authors.affiliation: Department of Immunology, University of Washington, Seattle, WA 98109, USA.
authors.forename: Johannes
authors.initials: J
authors.lastname: Schwerk
authors.affiliation: Department of Immunology, University of Washington, Seattle, WA 98109, USA.
authors.forename: Abigail P
authors.initials: AP
authors.lastname: Jarret
authors.affiliation: Department of Immunology, University of Washington, Seattle, WA 98109, USA.
authors.forename: Rochelle C
authors.initials: RC
authors.lastname: Joslyn
authors.affiliation: Department of Immunology, University of Washington, Seattle, WA 98109, USA. Electronic address: savanram@uw.edu.
authors.forename: Ram
authors.initials: R
authors.lastname: Savan
mesh_terms: D005786:Gene Expression Regulation; D016174:Hepacivirus / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D006526:Hepatitis C / Q000235:genetics* / Q000276:immunology / Q000821:virology; D054884:Host-Pathogen Interactions; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008957:Models, Genetic; D012323:RNA Processing, Post-Transcriptional; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding; D016601:RNA-Binding Proteins