title: Early screening for critical congenital heart defects in asymptomatic newborns in Bursa province.
abstract: OBJECTIVE
  In this study, pulse oximetry screening results in the early diagnosis of critical congenital heart diseases (CCHD) will be evaluated.
  
  
  METHODS
  Eight-thousand two-hundred and eight of 10,200 newborns born between January 2014 and December 2014 were screened using pulse oximetry for the diagnosis of CCHD. Screening test was considered to be positive in the newborns whose saturation after 24 h from the birth with pulse oximetry was ≤ 95% and/or in the newborns who had a difference of ≥ 3% between the lower and right upper extremity.
  
  
  RESULTS
  Incidence of CCHD was 1 per 1000 live births. Coarctation of the aorta was the most commonly determined CCHD. Sensitivity, specificity, false negative rate and false positive rate of pulse oximetry in the diagnosis of CCHD were 60%, 99.8%, 40% and 0.12%, respectively. Seventy-five percent of the newborns who had a false negative diagnosis with pulse oximetry had coarctation of the aorta. Coarctation of the aorta was determined at a rate of 20% using CCHD screening.
  
  
  CONCLUSIONS
  The diagnosis of coarctation of the aorta is missed in the newborns screened with pulse oximetry in the first 24-48 h after birth. Screening with pulse oximetry should be repeated for early diagnosis of coarctation of the aorta.
authors.affiliation: a Neonatal Intensive Care Unit, Zeynep Kamil Maternity and Children Training and Research Hospital , Istanbul , Turkey and.
authors.forename: Elif
authors.initials: E
authors.lastname: Özalkaya
authors.affiliation: b Neonatal Intensive Care Unit, Bursa Şevket Yılmaz Training and Research Hospital , Yıldırım/Bursa , Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Akdağ
authors.affiliation: b Neonatal Intensive Care Unit, Bursa Şevket Yılmaz Training and Research Hospital , Yıldırım/Bursa , Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Şen
authors.affiliation: b Neonatal Intensive Care Unit, Bursa Şevket Yılmaz Training and Research Hospital , Yıldırım/Bursa , Turkey.
authors.forename: Erol
authors.initials: E
authors.lastname: Cömert
authors.affiliation: b Neonatal Intensive Care Unit, Bursa Şevket Yılmaz Training and Research Hospital , Yıldırım/Bursa , Turkey.
authors.forename: Hamide
authors.initials: H
authors.lastname: Melek Yaren
mesh_terms: D058070:Asymptomatic Diseases; D042241:Early Diagnosis; D005188:False Negative Reactions; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening / Q000379:methods*; D010092:Oximetry / Q000379:methods; D012680:Sensitivity and Specificity; D014421:Turkey / Q000453:epidemiology
keywords: Asymptomatic newborns; critical congenital heart disease; pulse oximetry