title: Preparation of porous PLA/DBM composite biomaterials and experimental research of repair rabbit radius segmental bone defect.
abstract: Bone substitutes are used in wide range of orthopaedic application. An ideal bone substitute should exhibit superior osteoinductive and osteoconductive properties. Neither bio-derived materials nor synthetic materials can meet the needs of an ideal bone substitute. Preparation of composite materials is a promising way to improve properties of biomaterial. In this study, the porous poly lactic acid (PLA)/demineralized bone matrix (DBM) composite biomaterials prepared by supercritical CO2 technique were implanted to repair rabbit radius segmental bone defect. By comparing with PLA and bone autograft, the X-ray result and histological analysis showed the repair effect of PLA/DBM porous composite materials is significantly better than that of the PLA group and the blank control group, and is similar to autologous bone. The PLA/DBM can promote the healing of bone defects and can be used as a kind of ideal alternative materials to repair bone defects.
authors.affiliation: Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China. 9985855@qq.com.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Shanxi Medical University, Taiyuan, Shanxi, China.
authors.forename: Jianru
authors.initials: J
authors.lastname: Wang
authors.affiliation: Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China.
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.affiliation: Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Niu
authors.affiliation: Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China.
authors.forename: Jianchun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Gao
authors.affiliation: Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhai
authors.affiliation: Shanxi University of Traditional Chinese Medcine, Taiyuan, Shanxi, China.
authors.forename: Kaibo
authors.initials: K
authors.lastname: Chu
mesh_terms: D000818:Animals; D018775:Bone Demineralization Technique; D001857:Bone Matrix / Q000737:chemistry*; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000627:therapeutic use*; D017102:Fracture Healing; D019344:Lactic Acid / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D008422:Materials Testing; D011091:Polyesters; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use*; D016062:Porosity; D011817:Rabbits; D011859:Radiography; D011885:Radius Fractures / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)
keywords: Bone allograft; Composite biomaterials; Poly lactic acid; Supercritical CO2