title: Calibration-quality cancer nanotherapeutics.
abstract: Nanoparticle properties such as size, shape, deformability, and surface chemistry all play a role in nanomedicine drug delivery in cancer. While many studies address the behavior of particle systems in a biological setting, revealing how these properties work together presents unique challenges on the nanoscale. "Calibration-quality" control over such properties is needed to draw adequate conclusions that are independent of parameter variability. Furthermore, active targeting and drug loading strategies introduce even greater complexities via their potential to alter particle pharmacokinetics. Ultimately, the investigation and optimization of particle properties should be carried out in the appropriate preclinical tumor model. In doing so, translational efficacy improves as clinical tumor properties increase. Looking forward, the field of nanomedicine will continue to have significant clinical impacts as the capabilities of nanoparticulate drug delivery are further enhanced.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA, perryjl@email.unc.edu.
authors.forename: Jillian L
authors.initials: JL
authors.lastname: Perry
authors.forename: Marc P
authors.initials: MP
authors.lastname: Kai
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Reuter
authors.forename: Charles
authors.initials: C
authors.lastname: Bowerman
authors.forename: J
authors.initials: J
authors.lastname: Christopher Luft
authors.forename: Joseph M
authors.initials: JM
authors.lastname: DeSimone
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002138:Calibration; D016503:Drug Delivery Systems; D006801:Humans; D058726:Nanoconjugates / Q000737:chemistry* / Q000627:therapeutic use; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D058726:Nanoconjugates