title: Optimization of irradiance for photodynamic therapy of port-wine stain.
abstract: Controllable and effective irradiation of lesions is among the key factors that affect the potency of photodynamic therapy (PDT). An optimization method for the irradiance distribution of treatment was proposed which can be used to improve the efficacy of PDT and allow more lesions to receive the desired irradiance level in a single therapy session. With the proposed digital illumination binocular treatment system, the preferred surface normal vectors, irradiation angles, as well as area and weight coefficients of lesions can be achieved and used as characteristic parameters to optimize the irradiation direction. Two port-wine stain phantom experiments were performed. The comparison of the illumination area between preoptimization and postoptimization showed that the proposed method can effectively guide the light source control, improve the distribution of light dose, and increase the effective treatment area.
authors.affiliation: Beijing Institute of Technology, School of Life Science, Beijing 100081, China.
authors.forename: Feng-juan
authors.initials: FJ
authors.lastname: Zhang
authors.affiliation: Beijing Institute of Technology, School of Life Science, Beijing 100081, China.
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Hu
authors.affiliation: Beijing Institute of Technology, School of Optoelectronics, Beijing 100081, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Beijing Institute of Technology, School of Life Science, Beijing 100081, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
mesh_terms: D003198:Computer Simulation; D046169:Dermoscopy / Q000379:methods; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008027:Light; D008029:Lighting / Q000379:methods*; D008954:Models, Biological; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D019339:Port-Wine Stain / Q000188:drug therapy* / Q000473:pathology*; D011829:Radiation Dosage; D013813:Therapy, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents