title: Spontaneous intracranial hypotension presenting as thunderclap headache: a case report.
abstract: BACKGROUND
  Spontaneous intracranial hypotension is a rare but treatable cause of a disabling headache syndrome. It is characterized by positional orthostatic headache, pachymeningeal enhancement and low cerebrospinal fluid pressure. However, the spectrum of clinical and radiographic manifestations is varied and misdiagnosis is common even in the modern era of magnetic resonance imaging. Spontaneous intracranial hypotension presenting as thunderclap headache is recognized but rare.
  
  
  METHODS
  A 41-year-old Sri Lankan female presented with thunderclap headache associated with nausea and vomiting, but the headache was characterized by positional variation with aggravation in the upright posture and relief in the supine posture. Gadolinium-enhanced cranial magnetic resonance imaging demonstrated generalized meningeal enhancement and normal magnetic resonance angiography while lumbar puncture revealed a cerebrospinal fluid opening pressure of less than 30 millimetres of water. Magnetic resonance myelography failed to identify the site of cerebrospinal fluid leak. The patient was managed conservatively with bed-rest, intravenous hydration, analgesics and an increased intake of oral coffee which led to a gradual relief of headaches in the upright posture.
  
  
  CONCLUSIONS
  Spontaneous intracranial hypotension can rarely present as thunderclap headache. Awareness of its varied spectrum of presentations would avoid inappropriate investigations, misinterpretation of imaging results and ineffective treatment.
authors.affiliation: Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 08, Sri Lanka. thashichang@gmail.com.|University Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka. thashichang@gmail.com.
authors.forename: Thashi
authors.initials: T
authors.lastname: Chang
authors.affiliation: Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 08, Sri Lanka. chaturaka.rodrigo@gmail.com.|University Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka. chaturaka.rodrigo@gmail.com.
authors.forename: Chaturaka
authors.initials: C
authors.lastname: Rodrigo
authors.affiliation: University Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka. lasithamfc@gmail.com.
authors.forename: Lasitha
authors.initials: L
authors.lastname: Samarakoon
mesh_terms: D000328:Adult; D005260:Female; D051270:Headache Disorders, Primary / Q000209:etiology*; D006801:Humans; D019585:Intracranial Hypotension / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging