title: Cobalamin-dependent enzymatic O-, N-, and S-demethylation.
abstract: Cobalamine cofactors (vitamin B12) are complex organometallic molecules that are crucial for the activity of a variety of different interesting enzymes such as isomerases, methyltransferases, and dehalogenases. Developments in understanding the structure, mechanism, and role in nature of methylcobalamin-dependent methyltransferases make them excellent candidates for biotechnological applications such as biocatalytic dealkylation.
authors.affiliation: Austrian Centre of Industrial Biotechnology (ACIB) GmbH, c/o Department of Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria.
authors.forename: Nina
authors.initials: N
authors.lastname: Richter
authors.affiliation: Sandoz GmbH, Biocatalysis Laboratory, Biochemiestrasse 10, 6250 Kundl/Tirol, Austria.
authors.forename: Ferdinand
authors.initials: F
authors.lastname: Zepeck
authors.affiliation: Department of Chemistry, NAWI Graz, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria. Electronic address: wolfgang.kroutil@uni-graz.at.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kroutil
mesh_terms: D001709:Biotechnology; D008745:Methylation; D008780:Methyltransferases; D014805:Vitamin B 12
chemical_list: D008780:Methyltransferases; D014805:Vitamin B 12