title: The TL1A/DR3/DcR3 pathway in autoimmune rheumatic diseases.
abstract: OBJECTIVE
  TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. They constitute a cytokine system that actively interferes with the regulation of immune responses and may participate in the pathogenesis of autoimmune diseases.
  
  
  OBJECTIVE
  This review aims to present the current knowledge on the role of the TL1A/DR3/DcR3 system in the pathophysiology of autoimmune rheumatic diseases, with a focus on rheumatoid arthritis (RA).
  
  
  METHODS
  An extensive literature search was performed in the PubMed database using the following keywords: TL1A, death receptor 3, DR3, decoy receptor 3, DcR3, TNFSF15, TNFRSF25, and TNFSF6B. Studies were assessed and selected in view of their relevance to autoimmune rheumatic diseases.
  
  
  CONCLUSIONS
  The TL1A/DR3/DcR3 axis is a novel immune pathway that participates in the pathogenesis of a variety of autoimmune rheumatic diseases. These molecules may be promising therapeutic targets for inflammatory arthritis.
authors.affiliation: Academic Department of Gastroenterology, Laikon Hospital, Kapodistrian University of Athens, 17 Agiou Thoma St, Athens 11527, Greece.
authors.forename: Spyros I
authors.initials: SI
authors.lastname: Siakavellas
authors.affiliation: First Department of Propaedeutic and Internal Medicine, Laikon Hospital, Kapodistrian University of Athens, Athens, Greece.
authors.forename: Petros P
authors.initials: PP
authors.lastname: Sfikakis
authors.affiliation: Academic Department of Gastroenterology, Laikon Hospital, Kapodistrian University of Athens, 17 Agiou Thoma St, Athens 11527, Greece. Electronic address: gbamias@gmail.com.
authors.forename: Giorgos
authors.initials: G
authors.lastname: Bamias
mesh_terms: D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D053219:Receptors, Tumor Necrosis Factor, Member 25 / Q000378:metabolism*; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000378:metabolism*; D012216:Rheumatic Diseases / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15 / Q000378:metabolism*
chemical_list: D053219:Receptors, Tumor Necrosis Factor, Member 25; D053323:Receptors, Tumor Necrosis Factor, Member 6b; C506033:TNFRSF25 protein, human; C117026:TNFSF15 protein, human; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15
keywords: Autoimmune disease; DR3; DcR3; Rheumatic disease; TL1A