title: Remodeling process in right and left ventricle after percutaneous atrial septal defect closure in adult patients.
abstract: OBJECTIVE
  The aim of this study was to evaluate acute cardiac remodeling after transcatheter closure of atrial septal defect (ASD) in adult patients.
  
  
  METHODS
  This study included 19 patients (40.0 ± 13.51 mean age) with secundum ASD who underwent successful transcatheter closure. All patients received routine transthoracic echocardiography, including tissue Doppler left ventricle (LV) and right ventricle (RV) myocardial performance indices (MPI), mitral annular plane systolic excursion (MAPSE) and tricuspid annular plane systolic excursion (TAPSE) before ASD closure, on first day, and at first and third months after closure.
  
  
  RESULTS
  Left ventricle end-diastolic diameter (LVEDD) increased (37 ± 4 mm to 44 ± 5 mm, p<0.001); RVEDD decreased markedly after closure (40 ± 4 mm to 32 ± 5 mm, p<0.001); and differences existed in LV and RV adaptation. While MAPSE (1.87 ± 0.22 cm to 2.01 ± 0.23 cm, p<0.001) and LVMPI improved soon after procedure (0.44 ± 0.04 to 0.36 ± 0.03, p<0.001), RVMPI worsened until the first month post-procedure (0.25 ± 0.02 to 0.31 ± 0.03, p<0.001), but recovered by the third month follow-up visit (0.31 ± 0.03 to 0.27 ± 0.02, p<0.001). TAPSE remained unchanged (2.49 ± 0.46 cm to 2.51 ± 0.32 cm, p=0.078).
  
  
  CONCLUSIONS
  Closure of ASD using the Amplatzer Septal Occluder device led to a decrease in RV size and an increase in LV size. In the early period, while LV function improved, RV function deteriorated, probably due to RV functional and anatomical differences.
authors.affiliation: Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Kevser Gülcihan
authors.initials: KG
authors.lastname: Balcı
authors.affiliation: Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa Mücahit
authors.initials: MM
authors.lastname: Balcı
authors.affiliation: Department of Cardiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: Muhammed Murat
authors.initials: MM
authors.lastname: Aksoy
authors.affiliation: Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.
authors.forename: Samet
authors.initials: S
authors.lastname: Yılmaz
authors.affiliation: Department of Cardiology, Keçiören Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aytürk
authors.affiliation: Department of Cardiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Doğan
authors.affiliation: Department of Cardiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Yeter
authors.affiliation: Department of Cardiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Akdemir
mesh_terms: D000328:Adult; D015331:Cohort Studies; D015150:Echocardiography, Doppler; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000379:methods*; D020257:Ventricular Remodeling