title: [The up-to-date methods of management of NSAIDs-induced injuries of small intestine].
abstract: In the article the incidence, pathogenesis, clinical featuries, diagnostic, prevention and treatment of NSAIDs-induced injuries of small intestine are presented. The different strategies of management of NSAID-induced enteropathy, such as use of PPI, COX-2-inhibitors, prostaglandins, antibiotics and probiotics, new combination of NSAIDs with phosphatidylcholine, NO or H2S, food supplements and other drugs are discussed.
authors.forename: S M
authors.initials: SM
authors.lastname: Tkach
authors.forename: H P
authors.initials: HP
authors.lastname: Balabantseva
authors.forename: A R
authors.initials: AR
authors.lastname: Levchenko
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D005759:Gastroenteritis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D006862:Hydrogen Sulfide / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology; D008795:Metronidazole / Q000627:therapeutic use; D020030:Nitric Oxide Donors / Q000627:therapeutic use; D010713:Phosphatidylcholines / Q000627:therapeutic use; D019936:Probiotics / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D015363:Quinolones / Q000627:therapeutic use; D012460:Sulfasalazine / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D005765:Gastrointestinal Agents; D020030:Nitric Oxide Donors; D010713:Phosphatidylcholines; D054328:Proton Pump Inhibitors; D015363:Quinolones; D008795:Metronidazole; D012460:Sulfasalazine; C052785:rebamipide; D000409:Alanine; D006862:Hydrogen Sulfide