title: Anterior segment morphologic changes related to α-1 adrenergic receptor antagonists use.
abstract: OBJECTIVE
  To investigate possible changes in anterior segment parameters with the Pentacam in patients taking tamsulosin or doxazosin for benign prostatic hyperplasia.
  
  
  METHODS
  This prospective, cross-sectional study was conducted at Necip Fazil City Hospital, Kahramanmaras, Turkey. Patients included in the study were grouped as follows: 29 patients treated with tamsulosin (group 1), 27 patients treated with doxazosin (group 2), and 40 untreated controls (group 3). Right eyes of each patient were included in the study. All patients underwent examination with the Pentacam under standard dim light conditions and with undilated pupils. Anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) width, central corneal thickness (CCT), corneal volume (CV), and pupil diameter (PD) were recorded.
  
  
  RESULTS
  Mean duration of treatments was 2.7 ± 1.2 (1-5) and 2.4 ± 0.9 (1-5) years in groups 1 and 2 (p = 0.276). The ACD, ACV, ACA width, and PD were statistically significantly decreased in groups 1 and 2 when compared to group 3 (p&lt;0.05). There were no statistically significant differences among the groups in mean values of CCT and CV.
  
  
  CONCLUSIONS
  In this study, decreased ACD, ACV, ACA width, and PD values were detected in tamsulosin and doxazosin groups when compared to controls. These findings should be considered during anterior segment examinations and surgeries.
authors.affiliation: Department of Ophthalmology, Ataturk Training and Research Hospital, Ankara - Turkey.
authors.forename: Nilay
authors.initials: N
authors.lastname: Yuksel
authors.affiliation: Department of Ophthalmology, Kahramanmaras Necip Fazil City Hospital, Kahramanmaras - Turkey.
authors.forename: Mediha Dilek
authors.initials: MD
authors.lastname: Ozer
authors.affiliation: Department of Ophthalmology, Ataturk Training and Research Hospital, Ankara - Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Takmaz
authors.affiliation: Department of Ophthalmology, Ataturk Training and Research Hospital, Ankara - Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Ozen
authors.affiliation: Department of Urology, Kahramanmaras Necip Fazil City Hospital, Kahramanmaras - Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Metin
authors.affiliation: Department of Ophthalmology, Ataturk Training and Research Hospital, Ankara - Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Akcay
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000009:adverse effects*; D000368:Aged; D000869:Anterior Eye Segment / Q000187:drug effects* / Q000473:pathology; D003430:Cross-Sectional Studies; D017292:Doxazosin / Q000009:adverse effects*; D005128:Eye Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D010781:Photography; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000188:drug therapy; D013449:Sulfonamides / Q000009:adverse effects*; D000077409:Tamsulosin
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin; D017292:Doxazosin