title: [Extract of Hirudo medicinalis leeches: biogenic substance for the creation of effective drugs].
abstract: Investigations of the extract of medicinal leech Girulux established parameters that enable one to verify the authenticity of related drugs using the characteristics of their UV spectra the and anticoagulant and antithrombin activity. The limits of pH must range from 5.5 to 7.5. Pilot-scale series of medical leech extract are in compliance with terms of "microbiological purity" quality characteristics. The natural storage has been used to assess the temporal stability of leech extract. The obtained characteristics showed that the activity of extract was retained after 3-year storage.
authors.forename: G I
authors.initials: GI
authors.lastname: Nikonov
authors.forename: E A
authors.initials: EA
authors.lastname: Titova
authors.forename: A O
authors.initials: AO
authors.lastname: Lebedeva
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000032:analysis* / Q000737:chemistry; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D045424:Complex Mixtures / Q000032:analysis* / Q000737:chemistry; D004355:Drug Stability; D057075:Enzyme Assays; D004791:Enzyme Inhibitors / Q000032:analysis* / Q000737:chemistry; D005343:Fibrinolytic Agents / Q000032:analysis* / Q000737:chemistry; D047709:Hirudo medicinalis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D012996:Solutions; D013917:Thrombin / Q000037:antagonists & inhibitors; D014357:Trypsin / Q000737:chemistry
chemical_list: D000925:Anticoagulants; D045424:Complex Mixtures; D004791:Enzyme Inhibitors; D005343:Fibrinolytic Agents; D012996:Solutions; D002918:Chymotrypsin; D014357:Trypsin; D013917:Thrombin