title: A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.
abstract: The dominant model for eukaryotic cell cycle control proposes that cell cycle progression is driven by a succession of CDK complexes with different substrate specificities. However, in fission yeast it has been shown that a single CDK complex generated by the fusion of the Cdc13 cyclin with the CDK protein Cdc2 can drive the mitotic cell cycle. Meiosis is a modified cell cycle programme in which a single S-phase is followed by two consecutive rounds of chromosome segregation. Here we systematically analyse the requirements of the different fission yeast cyclins for meiotic cell cycle progression. We also show that a single Cdc13-Cdc2 complex, in the absence of the other cyclins, can drive the meiotic cell cycle. We propose that qualitatively different CDK complexes are not absolutely required for cell cycle progression either during mitosis or meiosis, and that a single CDK complex can drive both cell cycle programmes.
authors.affiliation: Cell Cycle Laboratory Cancer Research UK London Research Institute, London WC2A 3LY, UK.
authors.forename: Pilar
authors.initials: P
authors.lastname: Gutiérrez-Escribano
authors.affiliation: 1] Cell Cycle Laboratory Cancer Research UK London Research Institute, London WC2A 3LY, UK [2] Laboratory of Yeast Genetics and Cell Biology, Rockefeller University, New York, New York 10065, USA [3] The Francis Crick Institute, London NW1 2BE, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Nurse
mesh_terms: D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism*; D016213:Cyclins / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal / Q000502:physiology; D008540:Meiosis / Q000502:physiology*; D008938:Mitosis / Q000502:physiology*; D012568:Schizosaccharomyces / Q000502:physiology*; D013172:Spores, Fungal
chemical_list: D016213:Cyclins; D005656:Fungal Proteins; D018844:Cyclin-Dependent Kinases