title: The history of childhood trauma is associated with lipid disturbances and blood pressure in adult first-episode schizophrenia patients.
abstract: OBJECTIVE
  It has repeatedly been found that early-life traumatic events may contribute to metabolic dysregulation. Therefore, the aim of this study was to investigate the association between the history of childhood trauma and cardiovascular risk factors in first-episode schizophrenia (FES) patients.
  
  
  METHODS
  The history of childhood trauma was assessed using the Early Trauma Inventory Self Report - Short Form (ETISR-SF) in 83 FES patients. Based on the ETISR-SF, patients were divided into those with positive and negative history of childhood trauma: FES(+) and FES(-) patients. Serum levels of fasting glucose lipids, homocysteine, vitamin B12 and folate, as well as anthropometric parameters and resting systolic and diastolic blood pressure (SBP and DBP) were measured.
  
  
  RESULTS
  The history of childhood trauma was associated with higher low-density lipoprotein (LDL) levels, SBP and DBP after covarying for age, gender, body mass index, education and chlorpromazine equivalent. There were significant correlations between scores of distinct ETISR-SF subscales and LDL, high-density lipoprotein, SBP, DBP and the number of metabolic syndrome criteria.
  
  
  CONCLUSIONS
  Results of this study indicate that traumatic events during childhood might be related to higher resting blood pressure and higher LDL levels in adult FES patients.
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367, Wroclaw, Poland; Department of Genetics, Wroclaw Medical University, 1 Marcinkowski Street, 50-368, Wroclaw, Poland. Electronic address: mblazej@interia.eu.
authors.forename: Błażej
authors.initials: B
authors.lastname: Misiak
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367, Wroclaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kiejna
authors.affiliation: Department of Psychiatry, Wroclaw Medical University, 10 Pasteur Street, 50-367, Wroclaw, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Frydecka
mesh_terms: D000328:Adult; D000069586:Adult Survivors of Child Adverse Events / Q000706:statistics & numerical data*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D002784:Cholesterol / Q000378:metabolism; D050171:Dyslipidemias / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D005492:Folic Acid / Q000378:metabolism; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008075:Lipoproteins, HDL / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism; D012559:Schizophrenia / Q000188:drug therapy / Q000453:epidemiology* / Q000378:metabolism; D014805:Vitamin B 12 / Q000378:metabolism; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D006710:Homocysteine; D005492:Folic Acid; D002784:Cholesterol; D014805:Vitamin B 12
keywords: Blood pressure; Childhood trauma; Early life stress; First-episode schizophrenia; Lipids