title: Histrelin for central precocious puberty-a single surgeon experience.
abstract: BACKGROUND
  The most common cause of precocious puberty is idiopathic central precocious puberty (CPP), which is usually treated with monthly injections. An alternative treatment of precious puberty is a subcutaneous implant that contains histrelin acetate, which is continuously released for more than 1 y and then removed or replaced with a new implant.
  
  
  METHODS
  The aim of this study was to conduct a retrospective review of one surgeon's experience with the histrelin implant and to examine patient satisfaction. After obtaining institutional review board approval, the charts of all children who had undergone at least one implant were reviewed.
  
  
  RESULTS
  Fifty-eight children, average age 8.4 y old (range 7-14), underwent at least one histrelin implant insertion for treatment of CPP. Parents of 44 patients were able to be reached by telephone for this study and rated the histrelin implant treatment highly. All implants were placed, replaced, or removed without significant difficulty, and there were no complications.
  
  
  CONCLUSIONS
  This study suggests that the use of a histrelin subcutaneous implant for control of CPP is a safe and effective method for the treatment of this condition.
authors.affiliation: Virginia Commonwealth University Health System, Division of Pediatric Surgery, Department of General Surgery, Children's Hospital of Richmond, Richmond, Virginia.
authors.forename: Shannon
authors.initials: S
authors.lastname: Rosati
authors.affiliation: Virginia Commonwealth University Health System, Division of Pediatric Surgery, Department of General Surgery, Children's Hospital of Richmond, Richmond, Virginia.
authors.forename: Rami
authors.initials: R
authors.lastname: Maarouf
authors.affiliation: Virginia Commonwealth University School of Medicine, Richmond, Virginia.
authors.forename: Karen
authors.initials: K
authors.lastname: Brown
authors.affiliation: Virginia Commonwealth University School of Medicine, Richmond, Virginia.
authors.forename: Michael
authors.initials: M
authors.lastname: Poppe
authors.affiliation: Virginia Commonwealth University Health System, Division of Pediatric Surgery, Department of General Surgery, Children's Hospital of Richmond, Richmond, Virginia.
authors.forename: Dan
authors.initials: D
authors.lastname: Parrish
authors.affiliation: Virginia Commonwealth University Health System, Division of Pediatric Surgery, Department of General Surgery, Children's Hospital of Richmond, Richmond, Virginia.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Haynes
authors.affiliation: Virginia Commonwealth University Health System, Division of Pediatric Surgery, Department of General Surgery, Children's Hospital of Richmond, Richmond, Virginia. Electronic address: dalanning@vcu.edu.
authors.forename: David
authors.initials: D
authors.lastname: Lanning
mesh_terms: D000293:Adolescent; D002648:Child; D016292:Procedural Sedation; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D017060:Patient Satisfaction; D011629:Puberty, Precocious / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D007987:Gonadotropin-Releasing Hormone; C029256:histrelin
keywords: Central precocious puberty; Histrelin implant