title: The role of clinically significant portal hypertension in hepatic resection for hepatocellular carcinoma patients: a propensity score matching analysis.
abstract: BACKGROUND
  Whether portal hypertension (PHT) is an appropriate contraindication for hepatic resection (HR) in hepatocellular carcinoma (HCC) patient is still under debate.
  
  
  OBJECTIVE
  Our aim was to assess the impact of clinically significant PHT on postoperative complication and prognosis in HCC patients who undergo HR.
  
  
  METHODS
  Two hundred and nine HCC patients who underwent HR as the initial treatment were divided into two groups according to the presence (n = 102) or absence (n = 107) of clinically significant PHT. Propensity score matching (PSM) analysis was used to compare postoperative outcomes and survival.
  
  
  RESULTS
  Before PSM, PHT patients had higher rates of postoperative complication (43.1% vs. 23.4%; P = 0.002) and liver decompensation (37.3% vs. 17.8%; P = 0.002) with similar rates of recurrence-free survival (RFS; P = 0.369) and overall survival (OS; P = 0.205) compared with that of non-PHT patients. However, repeat analysis following PSM revealed similar rates of postoperative complication (32.2% vs. 39.0%; P = 0.442), liver decompensation (25.4% vs. 32.2%; P = 0.416), RFS (P = 0.481) and OS (P = 0.417; 59 patients in each group). Presence of PHT was not associated with complication by logistic regression analysis, or with overall survival by Cox regression analysis.
  
  
  CONCLUSIONS
  The presence of clinically significant PHT had no impact on postoperative complication and prognosis, and should not be regarded as a contraindication for HR in HCC patients.
authors.affiliation: State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. hewei@sysucc.org.cn.|Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. hewei@sysucc.org.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Surgery, People's Hospital of Jiangxi Province, Nanchang, China. qlzkz@163.com.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. zhengyun@sysucc.org.cn.|Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. zhengyun@sysucc.org.cn.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. chenmeix@sysucc.org.cn.
authors.forename: Meixian
authors.initials: M
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. shenjx@sysucc.org.cn.|Department of Medical Imaging and Interventional Center, Sun Yat-Sen University Cancer Center, Guangzhou, China. shenjx@sysucc.org.cn.
authors.forename: Jingxian
authors.initials: J
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. qiujl@sysucc.org.cn.|Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. qiujl@sysucc.org.cn.
authors.forename: Jiliang
authors.initials: J
authors.lastname: Qiu
authors.affiliation: Department of Surgery, People's Hospital of Jiangxi Province, Nanchang, China. chen2yangwei@126.com.
authors.forename: Miao
authors.initials: M
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. zourh@sysucc.org.cn.|Department of Ultrasound, Sun Yat-Sen University Cancer Center, Guangzhou, China. zourh@sysucc.org.cn.
authors.forename: Ruhai
authors.initials: R
authors.lastname: Zou
authors.affiliation: State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. liaoyd@sysucc.org.cn.|Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. liaoyd@sysucc.org.cn.
authors.forename: Yadi
authors.initials: Y
authors.lastname: Liao
authors.affiliation: State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. liqj@sysucc.org.cn.|Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. liqj@sysucc.org.cn.
authors.forename: Qijiong
authors.initials: Q
authors.lastname: Li
authors.affiliation: State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. wuxianq@sysucc.org.cn.|Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. wuxianq@sysucc.org.cn.
authors.forename: Xianqiu
authors.initials: X
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. libinkui@mail.sysu.edu.cn.|Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. libinkui@mail.sysu.edu.cn.
authors.forename: Binkui
authors.initials: B
authors.lastname: Li
authors.affiliation: State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. yuanyf@mail.sysu.edu.cn.|Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. yuanyf@mail.sysu.edu.cn.
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000473:pathology / Q000601:surgery*; D008099:Liver / Q000473:pathology / Q000601:surgery; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies