title: [Objective evaluation of CO2 laser in the treatment of Tis--T glottic carcinoma after operation for voice rehabilitation].
abstract: OBJECTIVE
  To objectively evaluate the voice rehabilitation status in different period after treatment of Tis--T1 glottic carcinoma by CO2 laser with voice parameters.
  
  
  METHODS
  A retrospective review of 41 cases with Tis--T1 glottic carcinoma treated by CO2 laser was performed, 23 cases were stage Tis (Tis group) and 18 cases with stage T1N0M0 (T1 group). The range of excision of the lesion by CO2 laser was according to the different stages of the tumor, and ensured theoperation negative margin was by intraoperative frozen pathological examination. We tested and compared the actual voice (coritaine F0, Jitter, Shimmer, NNE and MPT) of 30 cases of healthy middle-aged and old male(normal group) and all the patients at one day prior to operation, three months, six months and one year after operation respectively, which was to evaluate the voice rehabilitation status in different period after operation objectively.
  
  
  RESULTS
  Postoperative pathological examination revealed, 23 cases were squamous epithelium severe atypical hyperplasia, 16 cases were well differentiated squamous cell carcinoma, and 2 cases were moderately differentiated squamous cell carcinoma. Palatoglossal arch mucosal tear occurred in 3 patients. Respiratory difficulties were not seen in all cases, and normal oral feeding was obtained in all cases in postoperative three days. All patients were followed up for one year. There was statistical significance in F0, Jitter, Shimmer of both Tis group and T1 group after operation in different periods(P<0.05). But there was no statistical significance in NNE and MPT between six months and one years after operation in the two groups(P>0.05).
  
  
  CONCLUSIONS
  CO2 laser surgery is an effective treatment for early glottic carcinoma. Postoperative vocal function was improved in varying degrees, and voice quality gradually improved with the rehabilitation time. Partly objective parameters reflecting the vocal function gradually stabilized after half a year after operation.
authors.forename: Huizhong
authors.initials: H
authors.lastname: Wang
authors.forename: Fenglin
authors.initials: F
authors.lastname: Sun
authors.forename: Rongjun
authors.initials: R
authors.lastname: Man
authors.forename: Yang
authors.initials: Y
authors.lastname: Geng
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: Haipeng
authors.initials: H
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Gao
authors.forename: Rong
authors.initials: R
authors.lastname: Xu
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Xia
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000628:therapy*; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications / Q000628:therapy*; D053685:Laser Therapy; D054020:Lasers, Gas; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014833:Voice Quality