title: The importance of being dead: cell death mechanisms assessment in anti-sarcoma therapy.
abstract: Cell death can occur through different mechanisms, defined by their nature and physiological implications. Correct assessment of cell death is crucial for cancer therapy success. Sarcomas are a large and diverse group of neoplasias from mesenchymal origin. Among cell death types, apoptosis is by far the most studied in sarcomas. Albeit very promising in other fields, regulated necrosis and other cell death circumstances (as so-called "autophagic cell death" or "mitotic catastrophe") have not been yet properly addressed in sarcomas. Cell death is usually quantified in sarcomas by unspecific assays and in most cases the precise sequence of events remains poorly characterized. In this review, our main objective is to put into context the most recent sarcoma cell death findings in the more general landscape of different cell death modalities.
authors.affiliation: Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona , Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Rello-Varona
authors.affiliation: Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona , Spain.
authors.forename: David
authors.initials: D
authors.lastname: Herrero-Martín
authors.affiliation: Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona , Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Lagares-Tena
authors.affiliation: Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona , Spain.
authors.forename: Roser
authors.initials: R
authors.lastname: López-Alemany
authors.affiliation: Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona , Spain.
authors.forename: Núria
authors.initials: N
authors.lastname: Mulet-Margalef
authors.affiliation: Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona , Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Huertas-Martínez
authors.affiliation: Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona , Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Garcia-Monclús
authors.affiliation: Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona , Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: García Del Muro
authors.affiliation: Cell Death Regulation Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona , Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Muñoz-Pinedo
authors.affiliation: Sarcoma Research Group, Molecular Oncology Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona , Spain.
authors.forename: Oscar Martínez
authors.initials: OM
authors.lastname: Tirado
keywords: apoptosis; autophagic cell death; cell death mechanisms; mitotic catastrophe; necrosis; sarcoma; translocation-bearing sarcomas