title: White matter perivascular spaces on magnetic resonance imaging: marker of cerebrovascular amyloid burden?
abstract: OBJECTIVE
  We investigated the relationship between magnetic resonance imaging-visible centrum semiovale perivascular spaces (CSO-PVS), a biomarker of impaired interstitial fluid drainage, and positron emission tomography-based amyloid-β burden across a wide range of cerebrovascular amyloid deposition.
  
  
  METHODS
  Thirty-one nondemented subjects (11 probable cerebral amyloid angiopathy patients and 10 healthy subjects≥60 years; 10 older individuals, <60 years) had brain magnetic resonance imaging and Pittsburgh compound B-positron emission tomography. CSO-PVS was evaluated on T2-magnetic resonance imaging using a 4-point scale. The association between Pittsburgh compound B and CSO-PVS was assessed in linear regression.
  
  
  RESULTS
  In multivariable analyses adjusted for age, microbleeds and white matter hyperintensities, whole cortex Pittsburgh compound B binding was associated with CSO-PVS degree both as continuous (coefficient, 0.11; 95% confidence interval, 0.01-0.22; P=0.040) and as dichotomous variable (coefficient, 0.27; 95% confidence interval, 0.11-0.44; P=0.002). The median Pittsburgh compound B retention was higher in high versus low CSO-PVS degree (P=0.0007).
  
  
  CONCLUSIONS
  This pilot study suggests a possible association between cerebrovascular amyloid deposition and CSO-PVS, with potential pathophysiological implications.
authors.affiliation: From the UCL Institute of Neurology, Queen Square, London, United Kingdom (A.C., H.R.J., Z.F., D.J.W.); Wolfson Brain Imaging Centre (Y.T.H., F.I.A., T.D.F.), Division of Anaesthesia (D.K.M.), and Stroke Research Group, Department of Clinical Neurosciences (E.A.W., J.-C.B.), University of Cambridge, Cambridge, United Kingdom; and INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.). andreas.charidimou.09@ucl.ac.uk.
authors.forename: Andreas
authors.initials: A
authors.lastname: Charidimou
authors.affiliation: From the UCL Institute of Neurology, Queen Square, London, United Kingdom (A.C., H.R.J., Z.F., D.J.W.); Wolfson Brain Imaging Centre (Y.T.H., F.I.A., T.D.F.), Division of Anaesthesia (D.K.M.), and Stroke Research Group, Department of Clinical Neurosciences (E.A.W., J.-C.B.), University of Cambridge, Cambridge, United Kingdom; and INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.).
authors.forename: Young T
authors.initials: YT
authors.lastname: Hong
authors.affiliation: From the UCL Institute of Neurology, Queen Square, London, United Kingdom (A.C., H.R.J., Z.F., D.J.W.); Wolfson Brain Imaging Centre (Y.T.H., F.I.A., T.D.F.), Division of Anaesthesia (D.K.M.), and Stroke Research Group, Department of Clinical Neurosciences (E.A.W., J.-C.B.), University of Cambridge, Cambridge, United Kingdom; and INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.).
authors.forename: Hans R
authors.initials: HR
authors.lastname: Jäger
authors.affiliation: From the UCL Institute of Neurology, Queen Square, London, United Kingdom (A.C., H.R.J., Z.F., D.J.W.); Wolfson Brain Imaging Centre (Y.T.H., F.I.A., T.D.F.), Division of Anaesthesia (D.K.M.), and Stroke Research Group, Department of Clinical Neurosciences (E.A.W., J.-C.B.), University of Cambridge, Cambridge, United Kingdom; and INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.).
authors.forename: Zoe
authors.initials: Z
authors.lastname: Fox
authors.affiliation: From the UCL Institute of Neurology, Queen Square, London, United Kingdom (A.C., H.R.J., Z.F., D.J.W.); Wolfson Brain Imaging Centre (Y.T.H., F.I.A., T.D.F.), Division of Anaesthesia (D.K.M.), and Stroke Research Group, Department of Clinical Neurosciences (E.A.W., J.-C.B.), University of Cambridge, Cambridge, United Kingdom; and INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.).
authors.forename: Franklin I
authors.initials: FI
authors.lastname: Aigbirhio
authors.affiliation: From the UCL Institute of Neurology, Queen Square, London, United Kingdom (A.C., H.R.J., Z.F., D.J.W.); Wolfson Brain Imaging Centre (Y.T.H., F.I.A., T.D.F.), Division of Anaesthesia (D.K.M.), and Stroke Research Group, Department of Clinical Neurosciences (E.A.W., J.-C.B.), University of Cambridge, Cambridge, United Kingdom; and INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.).
authors.forename: Tim D
authors.initials: TD
authors.lastname: Fryer
authors.affiliation: From the UCL Institute of Neurology, Queen Square, London, United Kingdom (A.C., H.R.J., Z.F., D.J.W.); Wolfson Brain Imaging Centre (Y.T.H., F.I.A., T.D.F.), Division of Anaesthesia (D.K.M.), and Stroke Research Group, Department of Clinical Neurosciences (E.A.W., J.-C.B.), University of Cambridge, Cambridge, United Kingdom; and INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.).
authors.forename: David K
authors.initials: DK
authors.lastname: Menon
authors.affiliation: From the UCL Institute of Neurology, Queen Square, London, United Kingdom (A.C., H.R.J., Z.F., D.J.W.); Wolfson Brain Imaging Centre (Y.T.H., F.I.A., T.D.F.), Division of Anaesthesia (D.K.M.), and Stroke Research Group, Department of Clinical Neurosciences (E.A.W., J.-C.B.), University of Cambridge, Cambridge, United Kingdom; and INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.).
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Warburton
authors.affiliation: From the UCL Institute of Neurology, Queen Square, London, United Kingdom (A.C., H.R.J., Z.F., D.J.W.); Wolfson Brain Imaging Centre (Y.T.H., F.I.A., T.D.F.), Division of Anaesthesia (D.K.M.), and Stroke Research Group, Department of Clinical Neurosciences (E.A.W., J.-C.B.), University of Cambridge, Cambridge, United Kingdom; and INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.).
authors.forename: David J
authors.initials: DJ
authors.lastname: Werring
authors.affiliation: From the UCL Institute of Neurology, Queen Square, London, United Kingdom (A.C., H.R.J., Z.F., D.J.W.); Wolfson Brain Imaging Centre (Y.T.H., F.I.A., T.D.F.), Division of Anaesthesia (D.K.M.), and Stroke Research Group, Department of Clinical Neurosciences (E.A.W., J.-C.B.), University of Cambridge, Cambridge, United Kingdom; and INSERM U894, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cité, Paris, France (J.-C.B.).
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Baron
mesh_terms: D000328:Adult; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds / Q000008:administration & dosage; D015415:Biomarkers / Q000378:metabolism; D016657:Cerebral Amyloid Angiopathy / Q000000981:diagnostic imaging / Q000378:metabolism; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D013844:Thiazoles / Q000008:administration & dosage; D066127:White Matter / Q000000981:diagnostic imaging / Q000378:metabolism
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D015415:Biomarkers; D013844:Thiazoles
keywords: cerebral amyloid angiopathy