title: Relationship between neurocognition and functional recovery in first-episode schizophrenia: Results from the second year of the Oslo multi-follow-up study.
abstract: Lack of control of confounding variables, high attrition rate, and too few neurocognitive domains completed at each assessment point are some of the limitations identified in studies of the relationship between cognition and functional outcome in schizophrenia. In the ongoing Oslo multi-follow-up study 28 first episode schizophrenia patients and a pairwise matched control group (N=28) are assessed with the MATRICS Consensus Cognitive Battery (MCCB), a clinical interview, an inventory on social and role functioning and criteria of remission and recovery at several follow-up points. The current paper describes the rate of remission and full recovery, and investigates the relationship between neurocognition and functional outcome. At 2-year follow-up, 80.0% of the patients were in remission and 16.0% of them fulfilled the criteria for full recovery. The attrition rate was very low. In the follow-up period, there was a statistically significant decline in Verbal Learning and a significant improvement on Reasoning/Problem Solving and Social Cognition in the schizophrenia group, but not in the control group. This indicates a differentiated neurocognitive course. In the schizophrenia group, Attention/Vigilance and years of education at baseline were significant predictors of social and role functioning 2 years later.
authors.affiliation: Department of Psychology, University of Oslo, Norway. Electronic address: a.k.torgalsboen@psykologi.uio.no.
authors.forename: Anne-Kari
authors.initials: AK
authors.lastname: Torgalsbøen
authors.affiliation: Vestre Viken Hospital Trust, 3004 Drammen, Norway.
authors.forename: Christine
authors.initials: C
authors.lastname: Mohn
authors.affiliation: Department of Psychology, University of Oslo, Norway; Division of Mental Health, Norwegian Institute of Public Health, Postbox 4404, Nydalen N-0403 Oslo, Norway.
authors.forename: Nikolai
authors.initials: N
authors.lastname: Czajkowski
authors.affiliation: Department of Psychology, University of Oslo, Norway; Vestre Viken Hospital Trust, 3004 Drammen, Norway.
authors.forename: Bjørn Rishovd
authors.initials: BR
authors.lastname: Rund
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011340:Problem Solving / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012919:Social Behavior; D014706:Verbal Learning / Q000502:physiology; D055815:Young Adult
keywords: Cognition; First-episode psychosis; Functional recovery; Longitudinal