title: Ring-closing enyne metathesis of terminal alkynes with propargylic hindrance.
abstract: The ring closing enyne metathesis of substrates with propargylic hindrance was investigated, revealing the successful combination of the Stewart-Grubbs catalysts and microwave heating sometimes up to 170 °C for oxacycles. Medium-sized rings were obtained from terminal alkynes previously reputed as reluctant substrates. This unmatched combination was applied to the synthesis of carbocycles and oxacycles. In addition, this is the first report on the use of the Stewart Grubbs catalyst in ring closing enyne metatheses.
authors.affiliation: †Unité Molécules de Communication et Adaptation des Micro-organismes, Sorbonne Universités, Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique (CNRS UMR 7245), 57 rue Cuvier (CP 54), 75005 Paris, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Laroche
authors.affiliation: †Unité Molécules de Communication et Adaptation des Micro-organismes, Sorbonne Universités, Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique (CNRS UMR 7245), 57 rue Cuvier (CP 54), 75005 Paris, France.
authors.forename: Morgane
authors.initials: M
authors.lastname: Detraz
authors.affiliation: †Unité Molécules de Communication et Adaptation des Micro-organismes, Sorbonne Universités, Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique (CNRS UMR 7245), 57 rue Cuvier (CP 54), 75005 Paris, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Blond
authors.affiliation: †Unité Molécules de Communication et Adaptation des Micro-organismes, Sorbonne Universités, Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique (CNRS UMR 7245), 57 rue Cuvier (CP 54), 75005 Paris, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Dubost
authors.affiliation: ‡Unité Structure et instabilité des génomes, Sorbonne Universités, Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique (CNRS UMR 7196), Institut National de la Santé et de la Recherche Médicale (INSERM U 1154), 57 rue Cuvier (CP 26), 75005 Paris, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Mailliet
authors.affiliation: †Unité Molécules de Communication et Adaptation des Micro-organismes, Sorbonne Universités, Muséum National d'Histoire Naturelle, Centre National de la Recherche Scientifique (CNRS UMR 7245), 57 rue Cuvier (CP 54), 75005 Paris, France.
authors.forename: Bastien
authors.initials: B
authors.lastname: Nay
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D056831:Coordination Complexes; D012428:Ruthenium