title: Fatty liver disease might increase the risk of abdominal operation in patients with fatty liver and the prevalence of cancer in first-degree relatives.
abstract: OBJECTIVE
  We investigated the risk of abdominal operation in patients with fatty liver and the risk of any cancer in first-degree relatives of patients with fatty liver.
  
  
  METHODS
  We evaluated 105 patients with nonalcoholic fatty liver disease (NAFLD), 121 patients with biopsy-proven hepatitis C (61 patients with fatty liver and 60 patients without fatty liver), 50 patients with inflammatory bowel disease (IBD), and 109 patients with dyspepsia.
  
  
  RESULTS
  There was no difference in sex, mean age, and marital status among the groups except that patients with IBD were younger than the others (p<0.001). The frequency of cancer among family members was 18% in IBD, 9% in dyspepsia, 28% in hepatitis C with steatosis, 21.5% in hepatitis C without steatosis, and 27% in NAFLD (p=0.006). Then, we divided the study group into two groups as follows: group 1: (IBD+dyspepsia+hepatitis C without steatosis) and group 2: (hepatitis C with steatosis+NAFLD). We found that the frequency of cancer was 16% in group 1 versus 24.4 % in group 2 (p=0.037). We also investigated the risk of abdominal operation in patients with fatty liver. The results were as follows: 33% in group without fatty liver versus 43% in group with fatty liver (p=0.043).
  
  
  CONCLUSIONS
  Understanding the underlying causes of fatty liver forms might decrease the cancer frequency in the population and number of operations in patients with fatty liver.
authors.affiliation: Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey. drhakansenturk@yahoo.com.
authors.forename: Metin
authors.initials: M
authors.lastname: Başaranoğlu
authors.forename: Billur
authors.initials: B
authors.lastname: Canbakan
authors.forename: Kemal
authors.initials: K
authors.lastname: Yıldız
authors.forename: Bahadır
authors.initials: B
authors.lastname: Ceylan
authors.forename: Birol
authors.initials: B
authors.lastname: Baysal
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Uysal
authors.forename: Hakan
authors.initials: H
authors.lastname: Şentürk
mesh_terms: D000005:Abdomen / Q000601:surgery; D004415:Dyspepsia / Q000150:complications; D005260:Female; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications; D008297:Male; D009369:Neoplasms / Q000150:complications* / Q000453:epidemiology*; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000235:genetics / Q000601:surgery*; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment