title: Effective anthelmintic therapy of residents living in endemic area of high prevalence for Hookworm and Schistosoma mansoni infections enhances the levels of allergy risk factor anti-Der p1 IgE.
abstract: In this work were investigated the relationship between Hookworm/Schistosoma mansoni infections and allergy related risk factors in two endemic areas with distinct prevalence of infections and co-infection. The intensity of infections, eosinophilia, allergy risk factors, infections status and anti-Der p1 IgE levels before and 2 years (population 1) and 3 years (population 2) after anthelmintic treatment, were evaluated. It was observed that the population with lower prevalence and intensity of infection (population 2) had lower eosinophils counts (>600/mm(3)) and higher animal contact than the population with higher parasites intensity (population 1). After anthelmintic treatment the intensity of S. mansoni single infection decreased, but no changes were observed in Hookworm and co-infected individuals. The anthelmintic treatment also enhanced anti-Der p1 IgE optical density in ELISA on the subgroups that became negative for helminth infection regardless of their previous infection condition in population 1. Facing that, we evaluated the anti-Der p1 IgE reactivity index, and the ratio (after/before treatment) was significantly higher in patients co-infected before treatment. On the other hand, no association between anti-Der p1 IgE reactivity index and the intensity of infections were observed. In conclusion, effective anthelmintic therapy of subjects from endemic areas with high prevalence of Hookworm and S. mansoni infections enhances anti-Der p1 IgE levels.
authors.affiliation: Laboratório de Imunologia Celular e Molecular, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Sabrina S
authors.initials: SS
authors.lastname: Campolina
authors.affiliation: Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Marcio S S
authors.initials: MS
authors.lastname: Araujo
authors.affiliation: Faculdade de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Tércia M R L
authors.initials: TM
authors.lastname: Rezende
authors.affiliation: Laboratório de Imunologia Celular e Molecular, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Matoso
authors.affiliation: Faculdade de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Humberto F O
authors.initials: HF
authors.lastname: Quites
authors.affiliation: Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Andréa
authors.initials: A
authors.lastname: Teixeira-Carvalho
authors.affiliation: Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Olindo A
authors.initials: OA
authors.lastname: Martins-Filho
authors.affiliation: Faculdade de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil ; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Andrea
authors.initials: A
authors.lastname: Gazzinelli
authors.affiliation: Laboratório de Imunologia Celular e Molecular, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil ; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Belo Horizonte, Minas Gerais, Brazil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Correa-Oliveira
keywords: Allergic disorders; Allergy risk factors; Anti-Der p1 IgE