title: Cholinesterase-inhibitory diterpenoids and chemical constituents from aerial parts of Caryopteris mongolica.
abstract: A diterpenoid diglucoside (12,19-di-O-β-D-glucopyranosyl-11-hydroxyabieta-8,11,13-triene-19-one), isoscutellarein 7-O-[β-D-xylopyranosyl-(1→2)]-β-D-glucopyranoside, isoscutellarein 7-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside, hypolaetin 7-O-[6″-O-(p-E-coumaroyl)]-β-D-glucopyranoside, hypolaetin 7-O-[6″-O-(E-caffeoyl)]-β-D-glucopyranoside, and 15 known compounds were isolated from aerial parts of the Mongolian medicinal plant Caryopteris mongolica. The cholinesterase-inhibitory activities of the constituents were estimated. The abietane diterpenoids (12-O-demethylcryptojaponol and 6α-hydroxydemethylcryptojaponol) showed potent inhibitory activity against acetylcholinesterase from human erythrocytes and electric eel, and against butyrylcholinesterase from horse serum.
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai, 981-8558, Japan, murata-t@tohoku-pharm.ac.jp.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Murata
authors.forename: Erdenechimeg
authors.initials: E
authors.lastname: Selenge
authors.forename: Saki
authors.initials: S
authors.lastname: Oikawa
authors.forename: Keita
authors.initials: K
authors.lastname: Ageishi
authors.forename: Javzan
authors.initials: J
authors.lastname: Batkhuu
authors.forename: Kenroh
authors.initials: K
authors.lastname: Sasaki
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
mesh_terms: D004224:Diterpenes / Q000378:metabolism*; D019686:Lamiaceae / Q000737:chemistry* / Q000378:metabolism; D035261:Plant Components, Aerial / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D004224:Diterpenes