title: F-18 fluorodeoxyglucose positron emission tomography for differential diagnosis of pancreatic tumors.
abstract: Positron emission tomography with 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG-PET) has been proven useful for differentiating pancreatic ductal cancer from mass-forming chronic pancreatitis. However, there are particular pancreatic tumors having various grades of malignancy such as intraductal papillary mucinous neoplasm (IPMN) or pancreatic neuroendocrine tumor. We examined whether the cut-off value of maximum standardized uptake value (SUVmax) determined by pancreatic ductal cancers is also applicable for other pancreatic tumors. One hundred thirty six patients with pancreatic tumors underwent FDG-PET imaging. We first analyzed the cut-off value to differentiate pancreatic ductal cancers from mass-forming chronic pancreatitis. Secondly, we determined the cut-off value between malignant IPMN and benign IPMN. Thirdly, we computed a cut-off value between malignant pancreatic tumors and benign tumors irrespective of tumor type. The optimal cut-off value to differentiate ductal cancers from mass-forming chronic pancreatitis was 2.5. The optimal cut-off value for differentiating malignant IPMN from benign IPMN was also 2.5, similar to that of reported studies. In all types of pancreatic tumors, the cut-off value was also 2.5. The accuracy for detecting malignancy was 93.4% for all tumors. In the FDG-PET study for pancreatic tumors, an SUVmax of 2.5 would be justified as a cut-off value to differentiate malignant lesions.
authors.affiliation: Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543 Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Yoshioka
authors.affiliation: Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543 Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uchinami
authors.affiliation: Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543 Japan.
authors.forename: Go
authors.initials: G
authors.lastname: Watanabe
authors.affiliation: Department of Surgery, Akita City Hospital, Akita, 010-0933 Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Sato
authors.affiliation: Department of Surgery, Honjo Daiichi Hospital, Honjo, Akita, 015-8567 Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Shibata
authors.affiliation: Department of Surgery, Murakami Memorial Hospital, Asahi University, Gifu, 500-8523 Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kume
authors.affiliation: Department of Radiology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543 Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Ishiyama
authors.affiliation: Department of Radiology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543 Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Department of Radiology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543 Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hashimoto
authors.affiliation: Department of Gastroenterological Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543 Japan.
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Yamamoto
keywords: Cut-off; FDG-PET; IPMN; Non-ductal pancreatic cancer; SUV