title: Quantitative EEG Applying the Statistical Recognition Pattern Method: A Useful Tool in Dementia Diagnostic Workup.
abstract: OBJECTIVE
  The aim of this study was to examine the discriminatory power of quantitative EEG (qEEG) applying the statistical pattern recognition (SPR) method to separate Alzheimer's disease (AD) patients from elderly individuals without dementia and from other dementia patients.
  
  
  METHODS
  The participants were recruited from 6 Nordic memory clinics: 372 unselected patients [mean age 71.7 years (SD 8.6), 54% women] and 146 healthy elderly individuals [mean age 66.5 years (SD 7.7), 60% women]. After a standardized and comprehensive assessment, clinical diagnoses were made according to internationally accepted criteria by at least 2 clinicians. EEGs were recorded in a standardized way and analyzed independently of the clinical diagnoses, using the SPR method.
  
  
  RESULTS
  In receiver operating characteristic curve analyses, the qEEGs separated AD patients from healthy elderly individuals with an area under the curve (AUC) of 0.90, representing a sensitivity of 84% and a specificity of 81%. The qEEGs further separated patients with Lewy body dementia or Parkinson's disease dementia from AD patients with an AUC of 0.9, a sensitivity of 85% and a specificity of 87%.
  
  
  CONCLUSIONS
  qEEG using the SPR method could be a useful tool in dementia diagnostic workup.
authors.affiliation: Norwegian Advisory Unit for Ageing and Health, Vestfold Health Trust, Toensberg, Norway.
authors.forename: Knut
authors.initials: K
authors.lastname: Engedal
authors.forename: Jon
authors.initials: J
authors.lastname: Snaedal
authors.forename: Peter
authors.initials: P
authors.lastname: Hoegh
authors.forename: Vesna
authors.initials: V
authors.lastname: Jelic
authors.forename: Birgitte
authors.initials: B
authors.lastname: Bo Andersen
authors.forename: Mala
authors.initials: M
authors.lastname: Naik
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Wahlund
authors.forename: Anne-Rita
authors.initials: AR
authors.lastname: Oeksengaard
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000145:classification / Q000175:diagnosis*; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012372:ROC Curve