title: Working environment and myeloproliferative neoplasm: A population-based case-control study following a cluster investigation.
abstract: BACKGROUND
  Occupational exposures, including those to polycyclic aromatic hydrocarbons (PAH), are suspected risk factors for myeloproliferative neoplasms (MPN).
  
  
  METHODS
  We investigated occupational exposures and MPN risk (54 cases and 472 controls) in a population-based case-control study in three rural Pennsylvania counties. Occupational histories, coded to SIC/SOC 1980, were linked to a previously created PAH job-exposure matrix. Odds ratios for industry (17 categories), occupation (26 categories), and PAH exposure were adjusted using logistic regression.
  
  
  RESULTS
  No industries or occupations were strongly or consistently associated with increased MPN risk. Analysis of employment duration found that being employed for 5 or more years in transportation, communications, and other public utilities was associated with MPN risk. There was no indication of an association with cumulative PAH exposure.
  
  
  CONCLUSIONS
  These few associations did not appear to have a common exposure. This exploratory study does not support the hypothesis that occupational exposure, including PAH, are strong risk factors for MPNs.
authors.affiliation: Department of Environmental and Occupational Health, Drexel University, Philadelphia, Pennsylvania.
authors.forename: Karyn
authors.initials: K
authors.lastname: Heavner
authors.affiliation: Department of Environmental and Occupational Health, Drexel University, Philadelphia, Pennsylvania.|Environmental Protection Agency, Region 3, Philadelphia, Pennsylvania.
authors.forename: Carol Ann
authors.initials: CA
authors.lastname: Gross-Davis
authors.affiliation: Department of Environmental and Occupational Health, Drexel University, Philadelphia, Pennsylvania.
authors.forename: Arthur L
authors.initials: AL
authors.lastname: Frank
authors.affiliation: Drexel University, A.J. Drexel Autism Institute, Philadelphia, Pennsylvania.|Drexel University, Department of Epidemiology and Biostatistics, Philadelphia, Pennsylvania.
authors.forename: Craig
authors.initials: C
authors.lastname: Newschaffer
authors.affiliation: Department of Environmental and Occupational Health, Drexel University, Philadelphia, Pennsylvania.
authors.forename: Judith
authors.initials: J
authors.lastname: Klotz
authors.affiliation: Department of Environmental and Occupational Health, Drexel University, Philadelphia, Pennsylvania.|Drexel University, A.J. Drexel Autism Institute, Philadelphia, Pennsylvania.|Drexel University, Department of Epidemiology and Biostatistics, Philadelphia, Pennsylvania.
authors.forename: Igor
authors.initials: I
authors.lastname: Burstyn
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016000:Cluster Analysis; D004651:Employment; D005260:Female; D019337:Hematologic Neoplasms / Q000139:chemically induced*; D006801:Humans; D007221:Industry; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects; D009790:Occupations; D016017:Odds Ratio; D010414:Pennsylvania; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D012307:Risk Factors; D013997:Time Factors; D014186:Transportation; D017132:Workplace
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons
keywords: job-exposure matrix; myeloproliferative neoplasms; occupational exposure; polycyclic aromatic hydrocarbons; polycythemia vera