title: [Synthesis and cytotoxicity of triterpenoid seven members cyclic amines].
abstract: Synthesis of 3-deoxy-3a-homo-3a-aza-derivatives of betulin and erythrodiol from betulonic and oleanonic acids was carried out. The most antineoplastic activity with a wide range of action at in vitro testing showed 3-deoxy-3a-homo-3a-aza-28-hydroxy-12(13)-oleanene, which by results of profound studying could be recommended for in vivo investigation. Its modification in the C28 position by introduction of amethoxycinnamoyl fragment led to a loss of antineoplastic activity. 3-Deoxy-3a-homo-3a-aza-derivatives of betulin (3-(aminopropyl)-, 28-(2-carboxyethyl)carboxy-, and 28-cinnamoyloxy-) showed moderate antineoplastic activity in the case of Colon Cancer, Breast Cancer and Leukemia cell lines.
authors.forename: O B
authors.initials: OB
authors.lastname: Kazakova
authors.forename: G V
authors.initials: GV
authors.lastname: Giniiatullina
authors.forename: N I
authors.initials: NI
authors.lastname: Medvedeva
authors.forename: T V
authors.initials: TV
authors.lastname: Lopatina
authors.forename: I P
authors.initials: IP
authors.lastname: Baĭkova
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
authors.forename: G N
authors.initials: GN
authors.lastname: Apryshko
mesh_terms: D000218:Adamantane / Q000138:chemical synthesis / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D000094062:Betulinic Acid
chemical_list: D000218:Adamantane; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D009828:Oleanolic Acid; D014315:Triterpenes; C450739:oleanonic acid; C077953:erythrodiol; C002503:betulin; D000094062:Betulinic Acid