title: Laboratory alcohol self-administration experiments do not increase subsequent real-life drinking in young adult social drinkers.
abstract: BACKGROUND
  While the utility of experimental free-access alcohol self-administration paradigms is well established, little data exist addressing the question of whether study participation influences subsequent natural alcohol consumption. We here present drinking reports of young adults before and after participation in intravenous alcohol self-administration studies.
  
  
  METHODS
  Timeline Follow-back drinking reports for the 6 weeks immediately preceding the first, and the 6 weeks after the last experimental alcohol challenge were examined from subjects completing 1 of 2 similar alcohol self-administration paradigms. In study 1, 18 social drinkers (9 females, mean age 24.1 years) participated in 3 alcohol self-infusion sessions up to a maximum blood alcohol concentration (BAC) of 160 mg%. Study 2 involved 60 participants (30 females, mean age 18.3 years) of the Dresden Longitudinal Study on Alcohol Use in Young Adults (D-LAYA), who participated in 2 sessions of alcohol self-infusion up to a maximum BAC of 120 mg%, and a nonexposed age-matched control group of 42 (28 females, mean age 18.4 years) subjects.
  
  
  RESULTS
  In study 1, participants reported (3.7%) fewer heavy drinking days as well as a decrease of 2.5 drinks per drinking day after study participation compared to prestudy levels (p < 0.05, respectively). In study 2, alcohol-exposed participants reported 7.1% and non-alcohol-exposed controls 6.5% fewer drinking days at poststudy measurement (p < 0.001), while percent heavy drinking days and drinks per drinking day did not differ.
  
  
  CONCLUSIONS
  These data suggest that participation in intravenous alcohol self-administration experiments does not increase subsequent real-life drinking of young adults.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Sommer
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Seipt
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: Maik
authors.initials: M
authors.lastname: Spreer
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: Toni
authors.initials: T
authors.lastname: Blümke
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Markovic
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Jünger
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Martin H
authors.initials: MH
authors.lastname: Plawecki
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
authors.forename: Ulrich S
authors.initials: US
authors.lastname: Zimmermann
mesh_terms: D061605:Administration, Intravenous; D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking; D000431:Ethanol / Q000008:administration & dosage* / Q000009:adverse effects*; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D012646:Self Administration; D012737:Sex Factors; D012907:Smoking; D055815:Young Adult
chemical_list: D000431:Ethanol
keywords: Alcohol Self-Infusion; Computer-Assisted Infusion System; Ethics; Family History of Alcoholism; Timeline Follow-Back