title: Tet2: breaking down barriers to T cell cytokine expression.
abstract: It has been unclear whether alteration in DNA methylation at cytokine genes during T helper (Th) cell differentiation is a cause or consequence of gene expression. In this issue of Immunity, Ichiyama et al. (2015) show that oxidation of 5-methylcytosine by the methylcytosine dioxygenase Tet2 regulates cytokine production in Th cells.
authors.affiliation: Molecular and Cellular Immunoregulation Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhong
authors.affiliation: Molecular and Cellular Immunoregulation Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: jfzhu@niaid.nih.gov.
authors.forename: Jinfang
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis*; D004268:DNA-Binding Proteins / Q000276:immunology*; D044127:Epigenesis, Genetic / Q000276:immunology*; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D016207:Cytokines; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins