title: Langerhans Cell Histiocytosis of the Temporal Bone.
abstract: Langerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features are exemplified in this sine qua non radiology-pathology correlation article.
authors.affiliation: Department of Radiology, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. dtg1@uchicago.edu.
authors.forename: Daniel Thomas
authors.initials: DT
authors.lastname: Ginat
authors.affiliation: Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Johnson
authors.affiliation: Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Cipriani
mesh_terms: D015415:Biomarkers / Q000032:analysis; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D013701:Temporal Bone / Q000473:pathology*
chemical_list: D015415:Biomarkers
keywords: CT; Cytology; Langerhans cell histiocytosis; MRI; Pathology; Temporal bone