title: Paclitaxel or 5-fluorouracil/esophageal stent combinations as a novel approach for the treatment of esophageal cancer.
abstract: Currently, esophageal cancer is rarely curable, and herein, a paclitaxel or 5-fluorouracil/esophageal stent combination (PTX or 5-FU/stent) was used to provide a new approach to treat this cancer. The PTX or 5-FU/stent was prepared by covering a nitinol stent with a bilayered polymer film that consisted of a layer of 50% PTX or 5-FU and a layer of drug-free backing. These treatment modalities were evaluated in vivo after implantation into the porcine esophagus. The percentages of the drugs that permeated from the backing layer over a period of 95 days were very small (0.61% for 5-FU), and an overwhelming majority of the PTX and the 5-FU was released from the other side of the film. During the follow-up period (120 days), the drug/stent was always maintained in the porcine esophagus, and did not show any obvious systemic or local toxicities. In contrast, this treatment had an effect on the inhibition of tissue proliferation and ulceration. In addition, the drug concentrations were highest in the esophagus compared with in the heart, liver, spleen, lung, kidney and blood (81500.0 ± 9475.2 ng/g vs. 3.9 ± 0.3 ng/mL of PTX in the plasma at 13 days). The PTX/stent and the 5-FU/stent have a dual function as both a stent and a local drug delivery device, which provides a potential treatment modality with high efficacy and non systematic toxicity for esophageal cancer.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Jieying
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Interventional Radiology, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Wang
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Keqin
authors.initials: K
authors.lastname: Wu
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 200240 Shanghai, China.
authors.forename: Weiluan
authors.initials: W
authors.lastname: Chen
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 200240 Shanghai, China. Electronic address: shenyuanyuan@sjtu.edu.cn.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 200240 Shanghai, China; School of Chemistry, University of Leeds, Leeds LS2 9JT, UK. Electronic address: srguo@sjtu.edu.cn.
authors.forename: Shengrong
authors.initials: S
authors.lastname: Guo
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage; D015607:Stents; D013552:Swine; D014018:Tissue Distribution
chemical_list: D017239:Paclitaxel; D005472:Fluorouracil
keywords: 5-Fluorouracil; Esophageal stent; In vivo evaluation; Paclitaxel