title: Differential roles of antimicrobials in the acquisition of drug resistance through activation of the SOS response in Acinetobacter baumannii.
abstract: The effect of antimicrobials on SOS-mediated mutagenesis induction depends on the bacterial species and the antimicrobial group. In this work, we studied the effect of different families of antimicrobial agents used in clinical therapy against Acinetobacter baumannii in the induction of mutagenesis in this multiresistant Gram-negative pathogen. The data showed that ciprofloxacin and tetracycline induce SOS-mediated mutagenesis, whereas colistin and meropenem, which are extensively used in clinical therapy, do not.
authors.affiliation: Departament de Genètica i Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.
authors.forename: Luis M
authors.initials: LM
authors.lastname: Jara
authors.affiliation: Departament de Genètica i Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Cortés
authors.affiliation: Servizo de Microbioloxía-INIBIC, Complexo Hospitalario Universitario A Coruña (CHUAC), A Coruña, Spain.
authors.forename: Germán
authors.initials: G
authors.lastname: Bou
authors.affiliation: Departament de Genètica i Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Barbé
authors.affiliation: Departament de Genètica i Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain jesus.aranda.rodriguez@gmail.com.
authors.forename: Jesús
authors.initials: J
authors.lastname: Aranda
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D003091:Colistin / Q000494:pharmacology; D015169:Colony Count, Microbial; D024881:Drug Resistance, Bacterial / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D016296:Mutagenesis / Q000187:drug effects; D012293:Rifampin / Q000494:pharmacology; D013014:SOS Response, Genetics / Q000187:drug effects*; D013754:Tetracyclines / Q000494:pharmacology; D013845:Thienamycins / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013754:Tetracyclines; D013845:Thienamycins; D002939:Ciprofloxacin; D000077731:Meropenem; D012293:Rifampin; D003091:Colistin