title: Oxidative stress as an indicator of the costs of reproduction among free-ranging rhesus macaques.
abstract: Sex differences in longevity may reflect sex-specific costs of intra-sexual competition and reproductive effort. As male rhesus macaques experience greater intrasexual competition and die younger, we predicted that males would experience greater oxidative stress than females and that oxidative stress would reflect sex-specific measures of reproductive effort. Males, relative to females, had higher concentrations of 8-OHdG and malondialdehyde, which are markers of DNA oxidative damage and lipid peroxidation, respectively. Older macaques had lower 8-OHdG levels than younger ones, suggesting that oxidative stress decreases in parallel with known age-related declines in reproductive investment. Among males, a recent period of social instability affected oxidative status: males who attacked others at higher rates had higher 8-OHdG levels. Multiparous lactating females with daughters had higher 8-OHdG levels than those with sons. No differences in antioxidant capacity were found. These results lend initial support for the use of oxidative stress markers to assess trade-offs between reproductive effort and somatic maintenance in primates.
authors.affiliation: Institute for Mind and Biology, The University of Chicago, 940 E 57th St, Chicago, IL 60637, USA georgiev@uchicago.edu.
authors.forename: Alexander V
authors.initials: AV
authors.lastname: Georgiev
authors.affiliation: Department of Anthropology, University of New Mexico, 500 University Blvd NE, Albuquerque, NM 87131, USA.
authors.forename: Melissa Emery
authors.initials: ME
authors.lastname: Thompson
authors.affiliation: Institute for Mind and Biology, The University of Chicago, 940 E 57th St, Chicago, IL 60637, USA Department of Psychology, New York University, 6 Washington Place, New York, NY 10003, USA.
authors.forename: Tara M
authors.initials: TM
authors.lastname: Mandalaywala
authors.affiliation: Institute for Mind and Biology, The University of Chicago, 940 E 57th St, Chicago, IL 60637, USA.
authors.forename: Dario
authors.initials: D
authors.lastname: Maestripieri
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D007774:Lactation; D015227:Lipid Peroxidation; D008253:Macaca mulatta / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology*; D012098:Reproduction; D012727:Sex Characteristics; D012919:Social Behavior
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
keywords: 8-OHdG; Antioxidant capacity; Maternal investment; Oxidative damage; Sex bias; TBARS