title: Motor neuron transduction after intracisternal delivery of AAV9 in a cynomolgus macaque.
abstract: The image shows a section of the lumbar spinal cord from a cynomolgus macaque that had received AAV9.CB.EGFP via the cisterna magna. Expression of GFP in multiple motor neurons is visible. Injection into the cerebrospinal fluid has been shown to be an effective route of vector administration for neuron transduction.
authors.affiliation: 1 Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine , Philadelphia, PA 19104.
authors.forename: Peter
authors.initials: P
authors.lastname: Bell
authors.forename: Christian
authors.initials: C
authors.lastname: Hinderer
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Louboutin
authors.forename: Hongwei
authors.initials: H
authors.lastname: Yu
authors.forename: Rebecca
authors.initials: R
authors.lastname: Grant
authors.forename: Erin
authors.initials: E
authors.lastname: Bote
authors.forename: James M
authors.initials: JM
authors.lastname: Wilson
mesh_terms: D000818:Animals; D002946:Cisterna Magna / Q000378:metabolism; D000229:Dependovirus / Q000235:genetics*; D005822:Genetic Vectors; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D007278:Injections, Spinal; D008159:Lumbar Vertebrae / Q000033:anatomy & histology; D008252:Macaca fascicularis; D009046:Motor Neurons / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D013116:Spinal Cord / Q000033:anatomy & histology; D014161:Transduction, Genetic
chemical_list: D049452:Green Fluorescent Proteins