title: Inflammation and congenital heart disease associated pulmonary hypertension.
abstract: BACKGROUND
  Increased blood flow may trigger pulmonary arterial wall inflammation, which may influence progression of pulmonary artery hypertension in patients with congenital heart disease. In this study, we aimed to investigate the correlation between preoperative inflammation markers and pulmonary arterial hypertension.
  
  
  METHODS
  A total of 201 patients with pulmonary hypertension were enrolled in this study retrospectively; they had undergone open heart surgery between January 2012 and December 2013. Patients' preoperative C-reactive protein (CRP), neutrophil to lymphocyte ratio, red blood cell distribution width, pulmonary pressures, and postoperative outcomes were evaluated.
  
  
  RESULTS
  Patient age, neutrophil to lymphocyte ratio, red blood cell distribution width, and CRP were found to be significantly correlated with both preoperative peak and mean pulmonary artery pressures. These data were entered into a linear logistic regression analysis. Patient age, neutrophil to lymphocyte ratio, and CRP were found to be independently correlated with peak pulmonary pressure (P &lt; .001, P &lt; .001, and P = .004) and mean pulmonary artery pressure (P &lt; .001, P &lt; .001, and P = .001), whereas preoperative mean pulmonary artery pressure was found to be independently correlated with intensive care unit stay (P &lt; .001). No parameter was found to be significantly correlated with extubation time and mortality. Eighteen patients had experienced pulmonary hypertensive crisis; in this subgroup, patients' mean pulmonary artery pressure and neutrophil to lymphocyte ratio were found to be significant (P = .047, P = .003).
  
  
  CONCLUSIONS
  Preoperative inflammation markers may be correlated with the progression of pulmonary hypertensive disease, but further studies with larger sample size are needed to determine the predictive role of these markers for postoperative outcomes.
authors.affiliation: Department of Cardiovascular Surgery, Acibadem International Hospital, Istanbul, Turkey. Email:metegursoy35@gmail.com.
authors.forename: Mete
authors.initials: M
authors.lastname: Gursoy
authors.affiliation: Department of Pediatric Cardiovascular Surgery Istanbul Medipol University, Istanbul, Turkey.
authors.forename: Ece
authors.initials: E
authors.lastname: Salihoglu
authors.affiliation: Department of Pediatric Cardiovascular Surgery, Kartal Kosuyolu Yüksek Ihtisas Training and Research Hospital, Istanbul, Turkey.|Department of Cardiovascular Surgery, Istanbul University Institute of Cardiology, Istanbul, Turkey.
authors.forename: Ali Can
authors.initials: AC
authors.lastname: Hatemi
authors.affiliation: Department of Cardiovascular Surgery, Acibadem International Hospital, Istanbul, Turkey. Email:metegursoy35@gmail.com.
authors.forename: A Faruk
authors.initials: AF
authors.lastname: Hokenek
authors.affiliation: Department of Pediatric Cardiovascular Surgery, Gaziosmanpasa Hospital, Istanbul, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Ozkan
authors.affiliation: Department of Pediatric Cardiovascular Surgery, Kartal Kosuyolu Yüksek Ihtisas Training and Research Hospital, Istanbul, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Ceyran
mesh_terms: D000293:Adolescent; D001167:Arteritis / Q000097:blood* / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D015984:Causality; D015897:Comorbidity; D016207:Cytokines / Q000097:blood; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000453:epidemiology*; D008297:Male; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D016207:Cytokines