title: Electrochemical sensor for paracetamol recognition and detection based on catalytic and imprinted composite film.
abstract: A new strategy for a composite film based electrochemical sensor was developed in this work. A layer of conductive film of poly(p-aminobenzene sulfonic acid) (pABSA) was electropolymerized onto glassy carbon electrode surface and exhibited a high electrocatalytic active for paracetamol (PR) redox. The subsequent formation of a layer of molecular imprinted polymer (MIP) film on pABSA modified electrode endowed the sensor with plentiful imprinted cavities for PR specific adsorption. The advantages of the composite film made the prepared sensor display high sensitivity and good selectivity for PR detection and recognition. Under the optimal conditions, the sensor could recognize PR from its interferents. A linear ranging from 5.0 × 10(-8) to 1.0 × 10(-4)mol/L for PR detection was obtained with a detection limit of 4.3 × 10(-8)mol/L. The sensor has been applied to analyze PR in tablets and human urine samples with satisfactory results. The simple, low cost, and efficient strategy reported here can be further used to prepare electrochemical sensors for other compounds recognition and detection.
authors.affiliation: College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China; The Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, Anhui Key Laboratory of Chemo-Biosensing, Anhui Key Laboratory of Functional Molecular Solids, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Teng
authors.affiliation: College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China; The Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, Anhui Key Laboratory of Chemo-Biosensing, Anhui Key Laboratory of Functional Molecular Solids, PR China.
authors.forename: Limei
authors.initials: L
authors.lastname: Fan
authors.affiliation: College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China; The Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, Anhui Key Laboratory of Chemo-Biosensing, Anhui Key Laboratory of Functional Molecular Solids, PR China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Dai
authors.affiliation: College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China; The Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, Anhui Key Laboratory of Chemo-Biosensing, Anhui Key Laboratory of Functional Molecular Solids, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhong
authors.affiliation: College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China; The Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, Anhui Key Laboratory of Chemo-Biosensing, Anhui Key Laboratory of Functional Molecular Solids, PR China.
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Lu
authors.affiliation: College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China; The Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, Anhui Key Laboratory of Chemo-Biosensing, Anhui Key Laboratory of Functional Molecular Solids, PR China. Electronic address: kanxw@mail.ahnu.edu.cn.
authors.forename: Xianwen
authors.initials: X
authors.lastname: Kan
mesh_terms: D000082:Acetaminophen / Q000032:analysis* / Q000652:urine*; D000327:Adsorption; D018712:Analgesics, Non-Narcotic / Q000032:analysis* / Q000652:urine*; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D006801:Humans; D057230:Limit of Detection; D054802:Molecular Imprinting / Q000379:methods; D010655:Phenylenediamines / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry; D013607:Tablets
chemical_list: D018712:Analgesics, Non-Narcotic; D010655:Phenylenediamines; D013451:Sulfonic Acids; D013607:Tablets; C453960:poly-(1,2-diaminobenzene); D000082:Acetaminophen
keywords: Conductive polymer; Electrocatalysis; Electrochemical sensor; Molecular imprinted polymer; Paracetamol