title: Hysteroscopic polypectomy decreases NF-κB1 expression in the mid-secretory endometrium of women with endometrial polyp.
abstract: OBJECTIVE
  Endometrial polyps have been identified as a possible factor for sub-fertility, their implication on endometrial NF-κB1 activity; the central regulator of the immune system gene expression involved in implantation has yet been little studied. We evaluated the NF-κB1 level and NF-κB p65 expression in the endometrium before and after hysteroscopic removal of the endometrial polyp during the mid-secretory phase.
  
  
  METHODS
  Infertile women with polyp (n=15) were enrolled. Unexplained infertile patients with normal endometrium (n=5) and healthy fertile women (n=5) were recruited as controls. Endometrial samples were obtained before and 4 months after the hysteroscopic polypectomy. NF-κB1 levels were analyzed by ELISA in the endometrium of all groups before and after polypectomy. The H-Score method was used to evaluate immunohistochemical NF-κB p65 expression in the endometrium.
  
  
  RESULTS
  NF-κB1 expression and NF-κB p65 immunoreactivity in the endometrium were significantly higher in women with polyp compared to unexplained infertile and fertile controls. Hysteroscopic polypectomy resulted in a significant decrease in endometrium NF-κB1 and NF-κB p65 activity.
  
  
  CONCLUSIONS
  Endometrium of women with endometrial polyp has abnormalities in expression of NF-κB1 and NF-κB p65 which may contribute to endometrial receptivity and so polyp related sub-fertility. Hysteroscopic polypectomy may help to the normalization of endometrial NF-κB concentrations.
authors.affiliation: Kafkas University School of Medicine, Department of Obstetrics and Gynecology, Kars, Turkey. Electronic address: jindrmb@yahoo.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Bozkurt
authors.affiliation: Kafkas University School of Medicine, Department of Obstetrics and Gynecology, Kars, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Şahin
authors.affiliation: Fırat University School of Medicine, Department of Physiology, Elazığ, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ulaş
mesh_terms: D000328:Adult; D004717:Endometrium / Q000737:chemistry*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D007247:Infertility, Female / Q000150:complications; D008183:Luteal Phase; D016328:NF-kappa B / Q000032:analysis*; D011127:Polyps / Q000150:complications / Q000601:surgery*; D014591:Uterine Diseases / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D055815:Young Adult
chemical_list: D016328:NF-kappa B
keywords: Endometrial polyps; Hysteroscopic polypectomy; NF-κB1