title: Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors.
abstract: Rosacea is a chronic inflammatory skin condition that affects approximately 16 million Americans. Four distinct subtypes of rosacea have been recognized, with transient and nontransient facial flushing, telangiectasia, and inflammatory papules and pustules being among the more commonly recognized features. Although the exact pathogenesis of rosacea is unknown, dysregulation of the innate immune system, overgrowth of commensal skin organisms, and aberrant neurovascular signaling may all have a role in promoting the clinical features of rosacea.
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California.
authors.forename: Aimee M
authors.initials: AM
authors.lastname: Two
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California.
authors.forename: Wiggin
authors.initials: W
authors.lastname: Wu
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Gallo
authors.affiliation: Division of Dermatology, University of California San Diego, San Diego, California. Electronic address: thata@mail.ucsd.edu.
authors.forename: Tissa R
authors.initials: TR
authors.lastname: Hata
mesh_terms: D006801:Humans; D007107:Immune System / Q000382:microbiology / Q000503:physiopathology; D009420:Nervous System / Q000503:physiopathology; D012307:Risk Factors; D012393:Rosacea / Q000145:classification / Q000209:etiology / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D012867:Skin / Q000503:physiopathology; D014466:Ultraviolet Rays
keywords: cathelicidin; mast cells; matrix metalloproteinases; microbiome; rosacea; serine proteases; transient receptor potential channels; ultraviolet radiation