title: Summary of the UPICT Protocol for 18F-FDG PET/CT Imaging in Oncology Clinical Trials.
abstract: The Uniform Protocols for Imaging in Clinical Trials (UPICT) (18)F-FDG PET/CT protocol is intended to guide the performance of whole-body FDG PET/CT studies within the context of single- and multiple-center clinical trials of oncologic therapies by providing acceptable (minimum), target, and ideal standards for all phases of imaging. The aim is to minimize variability in intra- and intersubject, intra- and interplatform, interexamination, and interinstitutional primary or derived data. The goal of this condensed version of the much larger document is to make readers aware of the general content and subject area. The document has several main subjects: context of the imaging protocol within the clinical trial; site selection, qualification, and training; subject scheduling; subject preparation; imaging-related substance preparation and administration; imaging procedure; image postprocessing; image analysis; image interpretation; archiving and distribution of data; quality control; and imaging-associated risks and risk management.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa michael-graham@uiowa.edu.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Graham
authors.affiliation: Department of Radiology, Washington University School of Medicine, St. Louis, Missouri.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Wahl
authors.affiliation: Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
authors.forename: John M
authors.initials: JM
authors.lastname: Hoffman
authors.affiliation: Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Yap
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
authors.forename: John J
authors.initials: JJ
authors.lastname: Sunderland
authors.affiliation: Department of Radiology and Nuclear Medicine, VU University Medical Centre, Amsterdam, The Netherlands.
authors.forename: Ronald
authors.initials: R
authors.lastname: Boellaard
authors.affiliation: Perlman Advisory Group, LLC, Hillsdale, New York.
authors.forename: Eric S
authors.initials: ES
authors.lastname: Perlman
authors.affiliation: Department of Radiology, University of Washington, Seattle, Washington; and.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Kinahan
authors.affiliation: Center for Quantitative Cancer Imaging, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Christian
authors.affiliation: Department of Radiology and Nuclear Medicine, VU University Medical Centre, Amsterdam, The Netherlands.
authors.forename: Otto S
authors.initials: OS
authors.lastname: Hoekstra
authors.affiliation: Department of Radiology, Weill Cornell Medical College, New York, New York.
authors.forename: Gary S
authors.initials: GS
authors.lastname: Dorfman
mesh_terms: D002986:Clinical Trials as Topic; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008495:Medical Oncology / Q000592:standards; D009038:Motion; D064847:Multimodal Imaging / Q000379:methods* / Q000592:standards; D009369:Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods* / Q000592:standards; D011786:Quality Control; D015203:Reproducibility of Results; D012107:Research Design; D012119:Respiration; D012308:Risk Management; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards; D016896:Treatment Outcome
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: PET CT; fluorodeoxyglucose; guideline; protocol