title: Extracorporeal photopheresis performed on the CELLEX® compared with the UVAR-XTS® instrument is more efficient and better tolerated in children with steroid-refractory graft-versus-host disease.
abstract: Extracorporeal photopheresis (ECP) is an effective therapy in children with refractory graft-versus-host disease (GVHD). The two most frequently used instruments are UVAR-XTS® and CELLEX®. We performed a retrospective chart review of ten patients who underwent ECP with both UVAR-XTS® and CELLEX® instruments for steroid-refractory acute or chronic GVHD to compare instrument run times, percentages of cells treated, and complication rates. We found that compared to the UVAR-XTS® instrument, use of the CELLEX® instrument resulted in shorter run times, increased percentage of mononuclear cells treated, reduced incidence of line occlusions requiring TPA treatment, and decreased incidence of patient-related complications.
authors.affiliation: Department of Hematology/Oncology/BMT, Children's National Health System, Washington DC.
authors.forename: Ekta
authors.initials: E
authors.lastname: Kapadia
authors.affiliation: Department of Transfusion Medicine, Children's National Health System, Washington DC.
authors.forename: Edward
authors.initials: E
authors.lastname: Wong
authors.affiliation: Department of Hematology/Oncology/BMT, Children's National Health System, Washington DC.
authors.forename: Evelio
authors.initials: E
authors.lastname: Perez-Albuerne
authors.affiliation: Department of Hematology/Oncology/BMT, Children's National Health System, Washington DC.
authors.forename: David
authors.initials: D
authors.lastname: Jacobsohn
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D006086:Graft vs Host Disease / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D017893:Photopheresis / Q000295:instrumentation* / Q000379:methods; D012189:Retrospective Studies; D013256:Steroids / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D013256:Steroids
keywords: allogeneic transplantation; extracorporeal photopheresis; graft-versus-host-disease