title: [Fast treatment of septic shock saves lives. Although "early goal-directed therapy"-protocol does not show any effect in new studies].
abstract: Three recent randomised trials have shown a lack of effect of EGDT for the treatment of severe sepsis and septic shock. Notably, control group care was excellent in all trials, including early recognition, early and aggressive fluid resuscitation and prompt administration of antibiotics, and was reflected in a lower than expected mortality.The discussion emphasizes the need for continued vigilance and early aggressive management.
authors.affiliation: Lund University - Department of Anaesthesia and Intensive Care and Institute of Clinical Sciences Malmö Malmö, Sweden Lund University - Department of Anaesthesia and Intensive Care and Institute of Clinical Sciences Malmö Malmö, Sweden.
authors.forename: Michelle
authors.initials: M
authors.lastname: Chew
authors.affiliation: Karolinska Institutet - ANOPIVA Stockholm, Sweden Karolinska Institutet - ANOPIVA Stockholm, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Oldner
mesh_terms: D002985:Clinical Protocols; D061345:Early Medical Intervention; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012772:Shock, Septic / Q000401:mortality / Q000628:therapy*