title: Neutrophilic-chronic myeloid leukemia: A case report.
abstract: Neutrophilic-chronic myelogenous leukemia (CML-N) is a rare chronic myelogenous leukemia (CML) variant characterized by BCR-ABL1 positive chronic neutrophilia. It has a BCR breakpoint on chromosome 22 between exons 17 and 20 in a region designated as micro-BCR. It is thought to have a more benign course than classical CML. This case report describes a 41-year-old Saudi woman diagnosed with CML-N. The peripheral blood and bone marrow picture for her were dominated by segmented neutrophils and fluorescent in situ hybridization was positive for BCR/ABL fusion of t(9;22). Our patient eventually required a stem cell transplant because of imatinib intolerance and bone marrow failure believed to be induced by nilotinib.
authors.affiliation: Pathology Department, College of Medicine, Qassim University, Qassim, Saudi Arabia.
authors.forename: Nahlah S
authors.initials: NS
authors.lastname: Al Ghasham
keywords: Chronic myeloid leukemia (CML); Neutrophilia; Neutrophilic-chronic myeloid leukemia (CML-N)