title: Fabrication and spectroscopic studies of folic acid-conjugated Fe3O4@Au core-shell for targeted drug delivery application.
abstract: Gold coated magnetite core shell is a kind of nanoparticle that include magnetic iron oxide core with a thin layer nanogold. Fe3O4-gold core-shell nanostructure can be used in biomedical applications such as magnetic bioseparation, bioimaging, targeting drug delivery and cancer treatment. In this study, the synthesis and characterization of gold coated magnetite nanoparticles were discussed. Magnetite nanoparticles with an average size of 6 nm in diameter were synthesized by the chemical co-precipitation method and gold-coated Fe3O4 core-shell nanostructures were produced with an average size of 11.5 nm in diameter by reduction of Au(3+) with citrate ion in the presence of Fe3O4. Folate-conjugated gold coated magnetite nanoparticles were synthesized to targeting folate receptor that is overexpressed on the surface of cancerous cells. For this purpose, we used l-cysteine, as a bi-functional linker for attachment to gold surface and it was linked to the gold nanoparticles surface through its thiol group. Then, we conjugated amino-terminated nanoparticles to folic acid with an amide-linkage formation. These gold magnetic nanoparticles were characterized by various techniques such as X-ray powder diffraction (XRD) analysis, Fourier transform infrared spectrometer (FT-IR), UV-visible spectroscopy, transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), dispersive analysis of X-ray (EDAX) and vibrating sample magnetometer (VSM) analysis. The magnetic and optical properties of Fe3O4 nanostructure were changed by gold coating and attachment of l-cysteine and folic acid to Fe3O4@Au nanoparticles.
authors.affiliation: Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Karamipour
authors.affiliation: Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran. Electronic address: m.s.sadjad@gmail.com.
authors.forename: M S
authors.initials: MS
authors.lastname: Sadjadi
authors.affiliation: Department of Chemistry, Islamic Azad University, Varamin-Pishva Branch, Varamin, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Farhadyar
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D003545:Cysteine / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005492:Folic Acid / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy; D033362:Powder Diffraction; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D006046:Gold; D005492:Folic Acid; D003545:Cysteine
keywords: Cysteine; Folic acid conjugated; Gold coated magnetite