title: Responsive inverse opal hydrogels for the sensing of macromolecules.
abstract: Dual responsive inverse opal hydrogels were designed as autonomous sensor systems for (bio)macromolecules, exploiting the analyte-induced modulation of the opal's structural color. The systems that are based on oligo(ethylene glycol) macromonomers additionally incorporate comonomers with various recognition units. They combine a coil-to-globule collapse transition of the LCST type with sensitivity of the transition temperature toward molecular recognition processes. This enables the specific detection of macromolecular analytes, such as glycopolymers and proteins, by simple optical methods. While the inverse opal structure assists the effective diffusion even of large analytes into the photonic crystal, the stimulus responsiveness gives rise to strong shifts of the optical Bragg peak of more than 100 nm upon analyte binding at a given temperature. The systems' design provides a versatile platform for the development of easy-to-use, fast, and low-cost sensors for pathogens.
authors.affiliation: Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam-Golm (Germany) http://www.chem.uni-potsdam.de/groups/apc/
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Couturier
authors.affiliation: Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam-Golm (Germany) http://www.chem.uni-potsdam.de/groups/apc/
authors.forename: Martin
authors.initials: M
authors.lastname: Sütterlin
authors.affiliation: Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam-Golm (Germany) http://www.chem.uni-potsdam.de/groups/apc/. laschews@uni-potsdam.de.
authors.forename: André
authors.initials: A
authors.lastname: Laschewsky
authors.affiliation: Fraunhofer-Institut für Zelltherapie und Immunologie, Institutsteil Bioanalytik und Bioprozesse IZI-BB, Am Mühlenberg 13, 14476 Potsdam-Golm (Germany).
authors.forename: Cornelia
authors.initials: C
authors.lastname: Hettrich
authors.affiliation: Fraunhofer Institut für Angewandte Polymerforschung IAP, Geiselbergstr. 69, 14476 Potsdam-Golm (Germany) http://www.iap.fraunhofer.de/en.html. erik.wischerhoff@iap.fraunhofer.de.
authors.forename: Erik
authors.initials: E
authors.lastname: Wischerhoff
mesh_terms: D020100:Hydrogels / Q000737:chemistry*; D044367:Phase Transition; D011108:Polymers / Q000032:analysis* / Q000737:chemistry; D011506:Proteins / Q000032:analysis / Q000737:chemistry; D013053:Spectrophotometry; D044366:Transition Temperature; D014867:Water / Q000737:chemistry
chemical_list: D020100:Hydrogels; D011108:Polymers; D011506:Proteins; D014867:Water
keywords: hydrogels; photonic crystals; polymers; responsive materials; sensors