title: Multimarker Analysis for New Biomarkers in Relation to Central Arterial Stiffness and Hemodynamics in a Chinese Community-Dwelling Population.
abstract: Central arterial stiffness and hemodynamics independently reflect the risk of cardiovascular events. This Chinese community-based analysis was performed to evaluate the relationships of new biomarkers with central arterial stiffness and hemodynamics by a multimarker method. This analysis consisted of 1540 participants who were fully tested for the new biomarkers including N-terminal prohormone of brain natriuretic peptide, lipid accumulation product, triglyceride-high-density lipoprotein cholesterol (TG-HDL-c) ratio, uric acid, high-sensitivity C-reactive protein, and homocysteine. Carotid-femoral pulse wave velocity (cfPWV), central pulse pressure (cPP), and central augmentation index (cAIx) were measured. The median (range) age of entire cohort was 62 years (21-96 years), and 40.5% were males. The median (interquartile range) of cfPWV, cPP, and cAIx was 11.0 m/s (9.6-13.0 m/s), 42 mm Hg (35-52 mm Hg), and 28% (21%-33%), respectively. In multivariate analysis, participants with higher cfPWV had significantly higher age, peripheral pulse pressure, TG, TG-HDL-c ratio, and homocysteine levels compared with others (P < .05 for all). Multimarker analysis in a Chinese community-dwelling population reinforced the potential clinical value of plasma TG-HDL-c ratio and homocysteine levels as the biomarkers of increased arterial stiffness.
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China Department of Cardiology and Hainan Branch, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Shihui
authors.initials: S
authors.lastname: Fu
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China lleim@sina.com yeping301@sina.com.
authors.forename: Leiming
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China lleim@sina.com yeping301@sina.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
authors.forename: Wenkai
authors.initials: W
authors.lastname: Xiao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology / Q000503:physiopathology; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006439:Hemodynamics; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D057187:Independent Living; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D063177:Pulse Wave Analysis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D059289:Vascular Stiffness; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D014280:Triglycerides; D006710:Homocysteine
keywords: central arterial stiffness; central hemodynamics; new biomarkers