title: Metformin as a potential combination therapy with existing front-line antibiotics for Tuberculosis.
abstract: Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb) remains a global health concern. The evolution of various multi-drug resistant strains through genetic mutations or drug tolerant strains through bacterial persistence renders existing antibiotics ineffective. Hence there is need for the development of either new antibiotics or rationalizing approved drugs that can be utilized in combination with existing antibiotics as a therapeutic strategy. A comprehensive systems level mapping of metabolic complexity in Mtb revels a putative role of NDH-I in the formation of bacterial persistence under the influence of front-line antibiotics. Possibilities of targeting bacterial NDH-I with existing FDA approved drug for type-II diabetes, Metformin, along with existing front-line antibiotics is discussed and proposed as a potential combination therapy for TB.
authors.affiliation: Academy of Scientific and Innovative Research, New Delhi, India. vashishtrv@gmail.com.|CSIR-OSDD Unit, CSIR-IGIB, New Delhi, India. vashishtrv@gmail.com.
authors.forename: Rohit
authors.initials: R
authors.lastname: Vashisht
authors.affiliation: Academy of Scientific and Innovative Research, New Delhi, India. skb@igib.res.in.|CSIR-OSDD Unit, CSIR-IGIB, New Delhi, India. skb@igib.res.in.|CSIR-Institute of Genomics and Integrative Biology, New Delhi, India. skb@igib.res.in.
authors.forename: Samir K
authors.initials: SK
authors.lastname: Brahmachari
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D008687:Metformin / Q000627:therapeutic use*; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D008687:Metformin