title: Health risks from computed tomographic screening.
abstract: Results of the recent National Lung Cancer Screening Trial show a significant survival benefit for annual screening with a low-dose computed tomographic (CT) scan in high-risk individuals. This result has led the US Preventive Services Task Force to recommend annual low-dose CT scans for this at-risk population. Less well characterized are the risks from screening. The primary risks from screening are radiation exposure, false-positive results and unnecessary diagnostic and therapeutic procedures, overdiagnosis and overtreatment, and increased psychological distress. This article reviews these risks, which must be considered and weighed against the benefits when discussing enrollment with patients.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box: 8234, St Louis, MO 63110, USA. Electronic address: krantzs@wudosis.wustl.edu.
authors.forename: Seth B
authors.initials: SB
authors.lastname: Krantz
authors.affiliation: Section of Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box: 8234, St Louis, MO 63110, USA.
authors.forename: Bryan F
authors.initials: BF
authors.lastname: Meyers
mesh_terms: D055088:Early Detection of Cancer / Q000379:methods*; D005189:False Positive Reactions; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D000069342:Medical Overuse; D011829:Radiation Dosage; D000069079:Radiation Exposure / Q000009:adverse effects*; D012306:Risk; D012907:Smoking / Q000009:adverse effects; D014057:Tomography, X-Ray Computed / Q000009:adverse effects*; D019564:Unnecessary Procedures / Q000009:adverse effects
keywords: Lung cancer; Overdiagnosis; Risks; Screening