title: High leptospiremia is associated with low gamma-delta T cell counts.
abstract: The role of innate immune cells either to mount appropriate defense mechanisms or to drive uncontrolled tissue injuries during acute leptospirosis is poorly understood. This study aimed at characterizing the selective mobilization of innate immune cells and the level of target organ injuries in response to leptospiremia. We focused on gamma-delta (γ-δ) T cells. Patients were prospectively assessed for cell count by cytometry, for bacterial load by PCR in plasma samples and for levels of soluble acute phase tissue enzymes. We found that the level of γ-δ T cells was low and inversely correlated to liver injuries and leptospiremia.
authors.affiliation: Immunopathology and Infection Research Grouping (IRG), EA4517, UMR PIMIT, Université de la Réunion, Processus Infectieux en Milieu Insulaire Tropical, INSERM 1187, CNRS 9192, IRD 249, 97405 St Denis Cedex, La Réunion, France; Internal Medicine and Dermatology Unit, CHU Félix Guyon, St Denis, 97400 La Reunion, France. Electronic address: loic.raffray@chu-reunion.fr.
authors.forename: Loic
authors.initials: L
authors.lastname: Raffray
authors.affiliation: Immunopathology and Infection Research Grouping (IRG), EA4517, UMR PIMIT, Université de la Réunion, Processus Infectieux en Milieu Insulaire Tropical, INSERM 1187, CNRS 9192, IRD 249, 97405 St Denis Cedex, La Réunion, France; Microbiology/Virology Laboratory, Félix Guyon University Hospital of La Reunion, 97400 St Denis, La Reunion, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Giry
authors.affiliation: Internal Medicine Unit, GHER Hospital, 97470 St Benoit, La Reunion, France.
authors.forename: Yoga
authors.initials: Y
authors.lastname: Thirapathi
authors.affiliation: Internal Medicine Unit, GHER Hospital, 97470 St Benoit, La Reunion, France.
authors.forename: François
authors.initials: F
authors.lastname: Binois
authors.affiliation: Infectious Disease Unit, CHU Félix Guyon, 97400 St Denis, La Reunion, France.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Moiton
authors.affiliation: Infectious Disease Unit, CHU Félix Guyon, 97400 St Denis, La Reunion, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Lagrange-Xelot
authors.affiliation: Internal Medicine and Dermatology Unit, CHU Félix Guyon, St Denis, 97400 La Reunion, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Ferrandiz
authors.affiliation: Immunopathology and Infection Research Grouping (IRG), EA4517, UMR PIMIT, Université de la Réunion, Processus Infectieux en Milieu Insulaire Tropical, INSERM 1187, CNRS 9192, IRD 249, 97405 St Denis Cedex, La Réunion, France; Microbiology/Virology Laboratory, Félix Guyon University Hospital of La Reunion, 97400 St Denis, La Reunion, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Jaffar-Bandjee
authors.affiliation: Immunopathology and Infection Research Grouping (IRG), EA4517, UMR PIMIT, Université de la Réunion, Processus Infectieux en Milieu Insulaire Tropical, INSERM 1187, CNRS 9192, IRD 249, 97405 St Denis Cedex, La Réunion, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gasque
mesh_terms: D016470:Bacteremia / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007919:Leptospira; D007922:Leptospirosis / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: Bacteremia; Gamma–delta T cells antigen receptors; Innate immunity; Leptospirosis; Liver