title: Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer.
abstract: Myeloid zinc finger 1 (MZF1) belongs to the SCAN-Zinc Finger (SCAN-ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co-activators and co-repressors.
authors.affiliation: Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115.
authors.forename: Taka
authors.initials: T
authors.lastname: Eguchi
authors.affiliation: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892.
authors.forename: Thomas
authors.initials: T
authors.lastname: Prince
authors.affiliation: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115.
authors.forename: Barbara
authors.initials: B
authors.lastname: Wegiel
authors.affiliation: Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115.
authors.forename: Stuart K
authors.initials: SK
authors.lastname: Calderwood
mesh_terms: D002454:Cell Differentiation / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000096:biosynthesis / Q000235:genetics*; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D022423:Myeloid Cells / Q000378:metabolism* / Q000473:pathology; D010766:Phosphorylation; D011401:Promoter Regions, Genetic; D011499:Protein Processing, Post-Translational / Q000235:genetics; D058207:Sumoylation
chemical_list: D051741:Kruppel-Like Transcription Factors; C085969:MZF1 protein, human
keywords: CANCER; FINGER-1; INVASION; MYELOID; NUCLEAR BODY; SUMO; ZINC