title: The effect of bipolar electrocoagulation during ovarian cystectomy on ovarian reserve: a systematic review.
abstract: The aim of the present systematic review was to study the effect of bipolar electrocoagulation during ovarian cystectomy on ovarian reserve. We searched Medline (1966-2015), Scopus (2004-2015), ClinicalTrials.gov (2008-2015), and Cochrane Central Register (CENTRAL) databases along with reference lists of electronically retrieved studies. The levels of antimullerian hormone (AMH) and antral follicle count (AFC) at 1, 3, 6, and 12 months following the excision of the benign ovarian cyst were defined as primary outcomes. Eight studies were finally included in our systematic review, which recruited 545 women. A metaanalysis was precluded because of significant heterogeneity in the methodological characteristics of the included studies. Data from the included studies suggest that the use of bipolar coagulation compared with ovarian sutures seems to result in significantly lower AMH and AFC during the first 3 months following the excision of the ovarian cyst. Two studies reported that this effect seems to persist at 6 and 12 months postoperatively. Bipolar electrodiathermy seems to be accompanied by increased damage to ovarian reserve, which is indicated by the lower levels of AMH and AFC. However, definitive results are precluded because of the significant heterogeneity of included studies and the potential bias.
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research N. S. Christeas. Electronic address: pergialiotis@hotmail.com.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Pergialiotis
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research N. S. Christeas.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Prodromidou
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research N. S. Christeas.
authors.forename: Maximos
authors.initials: M
authors.lastname: Frountzas
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research N. S. Christeas.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Bitos
authors.affiliation: Laboratory of Experimental Surgery and Surgical Research N. S. Christeas.
authors.forename: Despina
authors.initials: D
authors.lastname: Perrea
authors.affiliation: Department of Obstetrics and Gynaecology, St George's Healthcare National Health Service Trust/St George's University of London.
authors.forename: Stergios K
authors.initials: SK
authors.lastname: Doumouchtsis
mesh_terms: D054304:Anti-Mullerian Hormone / Q000032:analysis; D002452:Cell Count; D004564:Electrocoagulation; D005260:Female; D006801:Humans; D010048:Ovarian Cysts / Q000601:surgery*; D006080:Ovarian Follicle / Q000166:cytology; D065851:Ovarian Reserve
chemical_list: D054304:Anti-Mullerian Hormone
keywords: antimullerian hormone; antral follicle count; bipolar; cystectomy; follicle-stimulating hormone