title: Association between low ankle-brachial index and accelerometer-derived sedentary and exercise time in the asymptomatic general population.
abstract: Sedentary behavior is an adverse health risk factor that is independent of physical activity. The relationship between sedentary behavior, exercise activity and the ankle-brachial index (ABI) is not well understood. We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004. Accelerometer data were used to quantify exercise and sedentary time for each participant. A low ABI was defined as a value <1.0 (including borderline values). Multi-variable adjusted logistic regression analyses were performed with sedentary and exercise times as independent variables, adjusting for important confounders. There were 1443 asymptomatic participants (mean age 61 years, 49% female, 55% current/prior smokers) with mean daily sedentary and exercise times of 454 ± 144 and 18 ± 20 minutes, respectively. Of the participants, 23% had an ABI <1.0 (8.7% with ABI <0.9). Sedentary time was positively associated with a low ABI (odds ratio [OR] 1.22 per 1 standard deviation [SD], [95% confidence interval (CI), 1.03-1.43]; p=0.02) while exercise time was inversely associated with a low ABI (OR 0.71 per 1 SD, [95% CI, 0.57-0.89]; p=0.003). Sedentary time is associated with low ABI values in the asymptomatic population. This association appears to be independent of exercise time and warrants further investigation.
authors.affiliation: Department of Internal Medicine, Division of Cardiovascular Medicine, Medical College of Wisconsin, USA.
authors.forename: Jacquelyn P
authors.initials: JP
authors.lastname: Kulinski
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, USA.
authors.forename: Monika
authors.initials: M
authors.lastname: Sanghavi
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, USA.
authors.forename: Colby R
authors.initials: CR
authors.lastname: Ayers
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, USA.
authors.forename: Sandeep R
authors.initials: SR
authors.lastname: Das
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, USA.
authors.forename: Subhash
authors.initials: S
authors.lastname: Banerjee
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, USA.
authors.forename: Jarett D
authors.initials: JD
authors.lastname: Berry
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, USA.
authors.forename: Tayo
authors.initials: T
authors.lastname: Addo
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: De Lemos
authors.affiliation: Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, USA dharam@post.harvard.edu.
authors.forename: Dharam J
authors.initials: DJ
authors.lastname: Kumbhani
mesh_terms: D056044:Actigraphy / Q000295:instrumentation*; D000368:Aged; D055109:Ankle Brachial Index; D058070:Asymptomatic Diseases; D016009:Chi-Square Distribution; D015444:Exercise; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D015999:Multivariate Analysis; D009749:Nutrition Surveys; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D011237:Predictive Value of Tests; D012307:Risk Factors; D057185:Sedentary Behavior; D013997:Time Factors; D014481:United States / Q000453:epidemiology
keywords: National Health and Nutrition Examination Survey (NHANES); accelerometer; ankle-brachial index; peripheral arterial disease; physical activity; sedentary