title: Characteristics of participants in peripartum interventional research.
abstract: OBJECTIVE
  To identify characteristics of pregnant women potentially influencing the decision to participate in peripartum interventional research.
  
  
  METHODS
  Women screened as eligible to participate in two prospective interventional trials conducted in the labor and delivery unit at a single center were included. Characteristics of eligible women were compared based on their decision whether to participate or not. The best predictors of research participation were identified using multivariable logistic regression analyses.
  
  
  RESULTS
  Of the 605 subjects who screened as eligible to participate, 363 (60%) agreed to participate and 242 (40%) declined. Women using a private obstetric provider or who had prior obstetrical complications were less likely to participate [aOR 0.6 (95% CI: 0.4-0.8)] and [aOR 0.6 (95% CI: 0.4-0.9)], respectively. A history of a mental health condition and a higher body mass index (BMI) were marginally more likely to participate [aOR 1.5 (95% CI: 1.0-2.3)] and [aOR 1.03 (95% CI: 1.0-1.1)], respectively. Overall logistic regression model R(2) was 0.23.
  
  
  CONCLUSIONS
  There are differences between eligible subjects who decide to participate or not participate in prospective peripartum interventional research. There is a need to better understand non-participation in order to improve recruitment of representative populations that allow more generalizable research results.
authors.affiliation: a Department of Obstetrics and Gynecology, Lehigh Valley Health Network , Allentown , PA , USA and.|b University of South Florida-Morsani College of Medicine , Tampa , FL , USA.
authors.forename: Hai-Yen
authors.initials: HY
authors.lastname: Nguyen
authors.affiliation: a Department of Obstetrics and Gynecology, Lehigh Valley Health Network , Allentown , PA , USA and.
authors.forename: Anita
authors.initials: A
authors.lastname: Kurt
authors.affiliation: a Department of Obstetrics and Gynecology, Lehigh Valley Health Network , Allentown , PA , USA and.|b University of South Florida-Morsani College of Medicine , Tampa , FL , USA.
authors.forename: Joanne N
authors.initials: JN
authors.lastname: Quiñones
authors.affiliation: a Department of Obstetrics and Gynecology, Lehigh Valley Health Network , Allentown , PA , USA and.|b University of South Florida-Morsani College of Medicine , Tampa , FL , USA.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Kiefer
authors.affiliation: a Department of Obstetrics and Gynecology, Lehigh Valley Health Network , Allentown , PA , USA and.|b University of South Florida-Morsani College of Medicine , Tampa , FL , USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Smulian
mesh_terms: D000328:Adult; D035843:Biomedical Research; D003657:Decision Making; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D010298:Parity; D010358:Patient Participation / Q000523:psychology / Q000706:statistics & numerical data; D018579:Patient Selection; D058725:Peripartum Period; D011247:Pregnancy; D037841:Pregnant People / Q000523:psychology; D016032:Randomized Controlled Trials as Topic / Q000523:psychology / Q000706:statistics & numerical data; D055815:Young Adult
keywords: Informed consent; perinatal research; pregnancy; randomized controlled trial; research participation