title: Itch, eosinophils, and autoimmunity: a novel murine model of bullous pemphigoid.
abstract: Mice carrying a deletion in the NC14A domain of murine type XVII collagen begin scratching at age 2 months and then develop erosions, subepidermal vesicles, eosinophil-rich skin infiltrates, and autoantibodies directed against a 180 kDa skin protein that appears to be type XVII collagen. These mice represent a bullous pemphigoid animal model featuring pruritus in immunocompetent, mature, and largely unmanipulated animals.
authors.affiliation: Department of Dermatology, University of Texas Southwestern Medical Center in Dallas, Dallas, Texas, USA. Electronic address: kim.yancey@utsouthwestern.edu.
authors.forename: Kim B
authors.initials: KB
authors.lastname: Yancey
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000235:genetics*; D015551:Autoimmunity / Q000235:genetics*; D001768:Blister / Q000235:genetics*; D000939:Epitopes / Q000235:genetics*; D017353:Gene Deletion; D024041:Non-Fibrillar Collagens / Q000235:genetics*; D010391:Pemphigoid, Bullous / Q000235:genetics*; D011537:Pruritus / Q000235:genetics*
chemical_list: D001324:Autoantigens; D000939:Epitopes; D024041:Non-Fibrillar Collagens