title: Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma.
abstract: OBJECTIVE
  To study the relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma.
  
  
  METHODS
  A total of 297 patients from July 2009 to May 2013 were chosen as objects. EGFR gene mutation were detected with fluorescence quantitative PCR. Relevance of EGFR gene mutation with clinical and pathological features was analyzed, and the prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was compared.
  
  
  RESULTS
  In 297 patients, 136 (45.79%) showed EGFR gene mutation. EGFR gene mutation had no significant relevance with age, gender, smoking history, family history of cancer and clinical stage (P>0.05); there was significant relevance between EGFR gene mutation and blood type, pathologic types, differentiation and diameter of cancer (P<0.05). The difference between prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was statistical significance (P<0.05).
  
  
  CONCLUSIONS
  EGFR gene mutation has significant relevance with pathological features, the prognosis of EGFR-mutant-patients is better than that of EGFR- wide type-patients.
authors.affiliation: Department of Thoracic Surgery, Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University, Yantai, Shandong Province, China.
authors.forename: Cheng-De
authors.initials: CD
authors.lastname: Wang
authors.affiliation: Department of Reproductive Medicine, Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University, Yantai, Shandong Province, China.
authors.forename: Xin-Rong
authors.initials: XR
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University, Yantai, Shandong Province, China.
authors.forename: Chao-Yang
authors.initials: CY
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University, Yantai, Shandong Province, China.
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Tang
authors.affiliation: Department of Thoracic Surgery, Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University, Yantai, Shandong Province, China. Electronic address: haowenmin126@126.com.
authors.forename: Ming-Wen
authors.initials: MW
authors.lastname: Hao
keywords: Epidermal growth factor receptor; Fluorescence quantitative PCR; Non–small–cell lung carcinoma; Pathological features; Prognosis