title: Diterpenes Synthesized from the Natural Serrulatane Leubethanol and Their in Vitro Activities against Mycobacterium tuberculosis.
abstract: Seventeen new derivatives of the natural diterpene leubethanol, including some potential pro-drugs, with changes in the functionality of the aliphatic chain or modifications of aromatic ring and the phenolic group, were synthesized and tested in vitro by the MABA technique for their activity against the H37Rv strain of Mycobacterium tuberculosis. Some compounds showed antimycobacterial selectivity indices higher than leubethanol.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain. ricar@usal.es.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Escarcena
authors.affiliation: Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Perez-Meseguer
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, CIETUS, IBSAL, Universidad de Salamanca, 37007-Salamanca, Spain. ricar@usal.es.
authors.forename: Esther
authors.initials: E
authors.lastname: Del Olmo
authors.affiliation: Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico.
authors.forename: Blanca
authors.initials: B
authors.lastname: Alanis-Garza
authors.affiliation: Servicio de Gastroenterología y Departamento de Patología Clínica, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo Leon, Av. Madero y Gonzalitos S/N, Mitras Centro, Monterrey, NL 64220, Mexico. elvira_garza_gzz@yahoo.com.
authors.forename: Elvira
authors.initials: E
authors.lastname: Garza-González
authors.affiliation: Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Salazar-Aranda
authors.affiliation: Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo Leon, PO Box 2316, Sucursal Tecnológico, Monterrey, NL 64841, Mexico. nwaksman@gmail.com.
authors.forename: Noemí
authors.initials: N
authors.lastname: Waksman de Torres
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011355:Prodrugs
chemical_list: D000995:Antitubercular Agents; D004224:Diterpenes; D011355:Prodrugs; C562290:leubethanol