title: TNF-α -308 G>A polymorphism and risk of bone marrow failure syndrome: A meta-analysis.
abstract: The influence of the TNF-α -308 G>A polymorphism on bone marrow failure syndrome susceptibility is unclear. We have conducted a meta-analysis of all relevant published studies. We searched PubMed, Chinese Biomedical Literature and China National Knowledge Infrastructure databases up to February 2015. Odds ratios (ORs) with 95% confidence intervals (CIs) were applied to assess the strength of associations. Eleven case-control studies with a total sample size of 909 cases and 1803 controls were eligible to assess the association between the TNF-α -308 G>A polymorphism and susceptibility to bone marrow failure syndrome. Overall, the TNF-α -308 G>A polymorphism was significantly associated with an increased risk of bone marrow failure syndrome in any genetic model. In stratified analysis by disease type, there was a significant association between the TNF-α -308 G>A polymorphism and increased risk of aplastic anemia but no significant association with myelodysplastic syndrome (AA vs. GG: OR=2.23, 95% CI=1.23-4.05, P=0.006; recessive model: OR=3.52, 95% CI=1.30-9.53, P=0.010). In subgroup analysis by ethnicity, there were significant associations between the TNF-α -308 G>A polymorphism and increased risk of bone marrow failure syndrome for Caucasians in two models, but not in Asian populations (AA vs. GG: OR=2.66, 95% CI=1.36-5.21, P=0.003; recessive model: OR=2.68, 95% CI=1.37-5.24, P=0.002). In conclusion, our meta-analysis suggests that the TNF-α -308 G>A polymorphism may contribute to the risk of bone marrow failure syndrome, particularly among Caucasian and aplastic anemia patients. Further investigations are needed to clarify the role of the TNF-α -308 G>A polymorphism in bone marrow failure syndrome.
authors.affiliation: Department of Hematology, First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors.forename: Wancheng
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
authors.forename: Haili
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Cancer Research Institute, Southern Medical University, Guangzhou 510515, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Hematology, First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Ziyuan
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Hematology, First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors.forename: Zhuoxin
authors.initials: Z
authors.lastname: Yao
authors.affiliation: Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China. Electronic address: jdxiao111@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D000741:Anemia, Aplastic / Q000208:ethnology / Q000235:genetics*; D001855:Bone Marrow Diseases; D000080983:Bone Marrow Failure Disorders; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006457:Hemoglobinuria, Paroxysmal / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha
keywords: Bone marrow failure syndrome; Meta-analysis; Polymorphism; TNF-α