title: Hypersomnolence in Wilson Disease.
abstract: Wilson disease (WD) is an autosomal recessive disorder of copper metabolism resulting in copper accumulation in a number of organs including the liver, brain, and cornea, predominantly leading to hepatic, neurologic, and psychiatric manifestations. An association between WD and sleep problems is not commonly recognized, and sleep complaints are often overlooked. Daytime hypersomnolence is even more rarely reported in this population. We report a case of WD and hypersomnolence objectively confirmed by a multiple sleep latency test (MSLT). Consequently, we suggest that increased awareness, assessment, and treatment of sleep disorders, including daytime sleepiness, may help improve patients' quality of life.
authors.affiliation: George Washington University, Washington, DC.|Department of Dermatology, University Hospital Zurich, Zürich, Switzerland.
authors.forename: Valerie C
authors.initials: VC
authors.lastname: Amann
authors.affiliation: Integrated Neurology Services, Alexandria, VA.
authors.forename: Neal K
authors.initials: NK
authors.lastname: Maru
authors.affiliation: George Washington University, Pulmonary and Critical Care Medicine, Washington, DC.
authors.forename: Vivek
authors.initials: V
authors.lastname: Jain
mesh_terms: D000328:Adult; D006970:Disorders of Excessive Somnolence / Q000209:etiology*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D017286:Polysomnography; D015032:Zinc / Q000627:therapeutic use
chemical_list: D015032:Zinc
keywords: Wilson disease; excessive daytime sleepiness; hypersomnolence; sleep disturbance