title: Calciphylaxis of the temporal artery masquerading as temporal arteritis: a case presentation and review of the literature.
abstract: An 82-year-old woman came to consultation with sudden visual loss in her left eye. Fifteen days before, she complained of diplopia. She had doubtful symptoms of giant cell arteritis and showed a normal physical exam. Lab results showed erythrosedimentation rate (ESR) = 62 mm/1°h; uremia = 0.56 g/dl (normal <0.45); serum creatinine = 1.7 mg% (normal <1.4); low calcium and phosphorus; and normal urine calcium and serous PTH. Fundus exam and brain magnetic resonance imaging (MRI) showed normality of optic nerves, chiasma, retrochiasmatic area, ocular muscles, eyeballs, lacrimal glands, periorbital fat, cavernous sinuses, and occipital cortex. A temporal arteritis was suspected; therefore, a biopsy was carried on. It showed the presence of large calcium deposits in the artery's tunica media and internal elastic lamina, with narrowing of the lumen, with no inflammation and multinuclear giant cells. Histological diagnosis is calciphylaxis. Although calciphylaxis is a well-described entity that occurs in end-stage renal patients, many cases are due to non-uremic causes. To date, there are only six cases described in literature of calciphylaxis mimicking GCA.
authors.affiliation: Rheumatology Section, J.M. Cullen Hospital, Santa Fe, Argentina. susanarove@yahoo.com.ar.
authors.forename: Susana
authors.initials: S
authors.lastname: Roverano
authors.affiliation: Rheumatology Section, J.M. Cullen Hospital, Santa Fe, Argentina.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortiz
authors.affiliation: Pathology Section, J.M. Cullen Hospital, Santa Fe, Argentina.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Henares
authors.affiliation: Pathology Section, J.M. Cullen Hospital, Santa Fe, Argentina.
authors.forename: Mónica
authors.initials: M
authors.lastname: Eletti
authors.affiliation: Rheumatology Section, J.M. Cullen Hospital, Santa Fe, Argentina.
authors.forename: Sergio
authors.initials: S
authors.lastname: Paira
mesh_terms: D000369:Aged, 80 and over; D001167:Arteritis / Q000175:diagnosis / Q000473:pathology; D001706:Biopsy; D001766:Blindness / Q000209:etiology; D002115:Calciphylaxis / Q000175:diagnosis* / Q000473:pathology; D004172:Diplopia / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D013699:Temporal Arteries / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology*
keywords: Calciphylaxis; Giant cell arteritis; Pseudovasculitis; Vasculitis