title: Co₉ Se₈ nanoplates as a new theranostic platform for photoacoustic/magnetic resonance dual-modal-imaging-guided chemo-photothermal combination therapy.
abstract: A new theranostic platform is developed based on biocompatible poly(acrylic acid) (PAA)-Co9 Se8 nanoplates. These PAA-Co9 Se8 nanoplates are successfully utilized for photoacoustic imaging (PAI)/magnetic resonance imaging (MRI) dual-modal imaging. Moreover, the PAA-Co9 Se8 -DOX shows pH-responsive chemotherapy and enables the combination of photothermal therapy and chemotherapy to receive superior antitumor efficacy. This work promises further exploration of 2D nanoplatforms for theranostic applications.
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry Fuzhou University, Fuzhou, 350108, PR China.
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Song
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University, Xiamen, 361005, PR China.
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Wang
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry Fuzhou University, Fuzhou, 350108, PR China.
authors.forename: Shu-Xian
authors.initials: SX
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University, Xiamen, 361005, PR China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Cao
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry Fuzhou University, Fuzhou, 350108, PR China.
authors.forename: Shi-Hua
authors.initials: SH
authors.lastname: Li
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry Fuzhou University, Fuzhou, 350108, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine School of Public Health, Xiamen University, Xiamen, 361005, PR China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: The Key Lab of Analysis and Detection Technology for Food Safety of the MOE State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry Fuzhou University, Fuzhou, 350108, PR China.
authors.forename: Huang-Hao
authors.initials: HH
authors.lastname: Yang
authors.affiliation: Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), MD, 20892, USA.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003035:Cobalt / Q000737:chemistry; D003131:Combined Modality Therapy / Q000295:instrumentation / Q000379:methods; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D008422:Materials Testing; D064847:Multimodal Imaging / Q000295:instrumentation / Q000379:methods; D049329:Nanostructures / Q000737:chemistry; D009368:Neoplasm Transplantation; D061088:Photoacoustic Techniques / Q000295:instrumentation* / Q000379:methods; D010789:Phototherapy / Q000295:instrumentation / Q000379:methods; D018036:Selenium Compounds / Q000138:chemical synthesis / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000295:instrumentation* / Q000379:methods
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003287:Contrast Media; D018036:Selenium Compounds; D003035:Cobalt; C006903:carbopol 940
keywords: chemotherapy; magnetic resonance imaging; nanoplates; photoacoustic imaging; photothermal therapy