title: Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology.
abstract: Sirtuins are evolutionarily conserved class III histone deacetylases that have been the focus of intense scrutiny and interest since the discovery of Sir2 as a yeast longevity factor. Early reports demonstrated an important role of Sirt1 in aging and metabolism, but its critical regulatory role in the immune system has only been unveiled in recent years. In this review we discuss the latest advances in understanding the regulatory role of Sirt1 in immune responses as well as how Sirt1 translates metabolic cues to immune signals, which would bring new insights into both pathogenesis and potential therapeutic strategies of a variety of immune-related diseases, such as cancer, microbial infection, autoimmune diseases and transplantation.
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Centre and Institute of Immunobiology, Fudan University, Shanghai, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Centre and Institute of Immunobiology, Fudan University, Shanghai, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Centre and Institute of Immunobiology, Fudan University, Shanghai, China.
authors.forename: Zhengguo
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Centre and Institute of Immunobiology, Fudan University, Shanghai, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Centre and Institute of Immunobiology, Fudan University, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.|Biotherapy Research Centre and Institute of Immunobiology, Fudan University, Shanghai, China.
authors.forename: Guangwei
authors.initials: G
authors.lastname: Liu
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007239:Infections / Q000276:immunology / Q000378:metabolism; D008136:Longevity / Q000276:immunology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000378:metabolism; D056564:Sirtuin 1 / Q000276:immunology* / Q000378:metabolism*; D056565:Sirtuin 2 / Q000378:metabolism; D014181:Transplantation Immunology
chemical_list: D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; C087778:SIR2 protein, S cerevisiae; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D056565:Sirtuin 2
keywords: Sirt1; T-cell activation; immune diseases; innate immune cells; metabolism; myeloid-derived suppressor cells; regulatory T cells