title: [The becoming of biological function of endoecology in phylogenesis. The support of "purity" of inter-cellular medium in paracrin cenosises of cells, organs and organism (a lecture)].
abstract: The decentralized system of resident macrophages phylogenetically is earlier and complement-depending one in every paracrin regulated cenosis of cells, intima of elastic type arteries. This system primarily utilizes protein macromolecules implementing biological reaction of transcytosis. The anatomically and functionally more perfect system of insulin-depended Kupffer macrophages in liver is centralized at the level of organism and is also intended to collect and utilize minor and protein biological "garbage". The various peptides, humoral active mediators, fragments of plasmatic membranes, integral proteins of micro RNA in hydrophilic medium of blood plasma are forming under their physical chemical interaction micro-particles, micro-vesicles and exosomes. All of them, under effect of IgG, absorb phylogenetically late Kupffer macrophages. The consequent system of implementation of biologic function of endoecology includes biologic reaction of exocytosis at autocrin level; complement-depended macrophages in paracrin cenosises of cells; resident macrophages in intima of elastic type arteries with reaction of transcytosis; centralized Kupffer macrophages in liver in sinusoidal capillaries and Disse spaces without reaction of transcytosis. The difference of function of systems makes it possible to make a conception of the role of biologic function of endoecology in pathological processes. Therefore, an opportunity appears to evaluate diagnostic value of methods based on detection of amount and quality composition of micro particles of blood plasma. This can be useful in differential diagnostic of metabolic pandemics.
authors.forename: V N
authors.initials: VN
authors.lastname: Titov
mesh_terms: D000818:Animals; D019898:Autocrine Communication / Q000502:physiology*; D055252:Cell-Derived Microparticles / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D007728:Kupffer Cells / Q000276:immunology*; D008099:Liver / Q000276:immunology*; D019899:Paracrine Communication / Q000502:physiology*; D010802:Phylogeny; D057900:Transcytosis / Q000502:physiology