title: A comparative study of variants of pegylated interferon alpha in treatment of chronic HCV patients.
abstract: HCV infection presents a vast burden in the regions of high prevalence such as Egypt, where most HCV isolates are genotype 4b. Combined treatment of three variants of pegylated interferon and ribavirin is still the standard of care in Egypt. However, no conclusive data confirming their efficacy are available. Here, 60 chronic HCV patients were randomized for ribavirin plus Peg Intron (PEG-IFNα-2b), Pegasys (PEG-IFNα-2a) or Reiveron Retard (PEG-IFNα-2a). Serum interferon and antibody (Ab) levels were measured, and responses and costs were compared. Serum interferon levels were higher in Pegasys group (1625.1 ng/mL) followed by Reiveron Retard (1076.5 ng/mL), and Peg Intron group (857.72 ng/mL). Moreover, Ab levels were the lowest in Reiveron Retard group (318.4 ng/mL), followed by Peg Intron (439.93 ng/mL), and Pegasys cases (610.83 ng/mL). The best 24-week response rates were detected in the Pegasys group (73.3%), followed by Peg Intron (66.67%), and Reiveron Retard (40%). Treatment with both Pegasys and Peg Intron were most cost-effective. Furthermore, Pegasys was superior in both 6-month response and serum interferon, despite having higher Ab levels (more antigenicity). Our data have notable clinical implications and suggest that Pegasys may be a superior choice of interferon therapy for chronic HCV under low socioeconomic conditions.
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, Egypt.|Department of Pharmacy, National Liver Institute, Menofiya University, Menofiya, Egypt.
authors.forename: Dalia
authors.initials: D
authors.lastname: El Sabaawy
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
authors.forename: Sahar
authors.initials: S
authors.lastname: El-Haggar
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
authors.forename: Hoda
authors.initials: H
authors.lastname: El-Bahrawy
authors.affiliation: Department of Hepatology, National Liver Institute, Menofiya University, Menofiya, Egypt.
authors.forename: Imam
authors.initials: I
authors.lastname: Waked
authors.affiliation: Department of Biochemistry, National Liver Institute, Menofiya University, Menofiya, Egypt.
authors.forename: Hala
authors.initials: H
authors.lastname: El-Said
mesh_terms: D000328:Adult; D057134:Antibodies, Neutralizing / Q000097:blood; D003362:Cost-Benefit Analysis; D004338:Drug Combinations; D004534:Egypt; D005260:Female; D005838:Genotype; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000494:pharmacology*; D015995:Prevalence; D011994:Recombinant Proteins / Q000097:blood / Q000494:pharmacology; D012254:Ribavirin / Q000494:pharmacology; D055815:Young Adult
chemical_list: D057134:Antibodies, Neutralizing; D004338:Drug Combinations; D018937:Hepatitis C Antibodies; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C417083:peginterferon alfa-2b; C100416:peginterferon alfa-2a
keywords: Chronic HCV; Serum interferon; antibodies; pegylated interferon