title: Potent inhibitory effects of D-tagatose on the acid production and water-insoluble glucan synthesis of Streptococcus mutans GS5 in the presence of sucrose.
abstract: We examined and compared the inhibitory effects of D-tagatose on the growth, acid production, and water-insoluble glucan synthesis of GS5, a bacterial strain of Streptococcus mutans, with those of xylitol, D-psicose, L-psicose and L-tagatose. GS5 was cultured for 12h in a medium containing 10% (w/v) of xylitol, D-psicose, L-psicose, D-tagatose or L-tagatose, and the inhibitory effect of GS5 growth was assessed. Each sugar showed different inhibitory effects on GS5. Both D-tagatose and xylitol significantly inhibited the acid production and water-insoluble glucan synthesis of GS5 in the presence of 1% (w/v) sucrose. However, the inhibitory effect of acid production by D-tagatose was significantly stronger than that of xylitol in presence of sucrose.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kagawa University, Miki, Kagawa 761-0793, Japan.daijo.sawada@gmail.com.
authors.forename: Daijo
authors.initials: D
authors.lastname: Sawada
authors.forename: Takaaki
authors.initials: T
authors.lastname: Ogawa
authors.forename: Minoru
authors.initials: M
authors.lastname: Miyake
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Hasui
authors.forename: Fuminori
authors.initials: F
authors.lastname: Yamaguchi
authors.forename: Ken
authors.initials: K
authors.lastname: Izumori
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tokuda
mesh_terms: D000143:Acids / Q000378:metabolism*; D005632:Fructose / Q000494:pharmacology; D005936:Glucans / Q000378:metabolism*; D006601:Hexoses / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007502:Iron Chelating Agents / Q000494:pharmacology; D008828:Microbiological Techniques; D013295:Streptococcus mutans / Q000145:classification* / Q000254:growth & development / Q000378:metabolism*; D013395:Sucrose / Q000494:pharmacology*; D014993:Xylitol / Q000494:pharmacology
chemical_list: D000143:Acids; D005936:Glucans; D006601:Hexoses; D007502:Iron Chelating Agents; C003243:psicose; D005632:Fructose; D013395:Sucrose; C030192:tagatose; D014993:Xylitol