title: [Fatigue in patients with multiple sclerosis--pathogenesis, clinical picture, diagnosis and treatment].
abstract: Fatigue is a frequent and restricting symptom of multiple sclerosis (MS). Starting from its pathogenetic mechanisms, the article develops an approach to the differential diagnosis of fatigue in MS patients. Over the past years, the use of functional imaging techniques has given important information on the mechanisms of this highly variable clinical picture. Considering our improved understanding of the interdependency of immune pathology and the clinical presentation of neuropsychological disorders, the relationship between immunomodulatory treatments and fatigue is receiving increased attention. Therefore, this article not only reports on the most recent data on pharmacological, physical and psychological interventions in the symptomatic treatment of fatigue, but also puts a special accent on data concerning the interactions between the rapidly growing number of immunomodulatory treatments in MS.
authors.affiliation: Institut für Physiologie, Universitätsmedizin Rostock.
authors.forename: R
authors.initials: R
authors.lastname: Patejdl
authors.affiliation: Kognitive Psychologie und Methodologie, Universität Basel.
authors.forename: I K
authors.initials: IK
authors.lastname: Penner
authors.affiliation: Institut für Physiologie, Universitätsmedizin Rostock.
authors.forename: T K
authors.initials: TK
authors.lastname: Noack
authors.affiliation: Klinik für Neurologie und Poliklinik, Universitätsmedizin Rostock.
authors.forename: U K
authors.initials: UK
authors.lastname: Zettl
mesh_terms: D005221:Fatigue / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy
chemical_list: D007155:Immunologic Factors