title: Exploring the molecular and chemical-physical aspects of low-dose irradiation using radio-tolerant plant cells.
abstract: Animals and plants show different levels of radio-sensitivity, with safe dose values in the 0.001-1 and 1-100 Gy range, respectively. The increased radio-tolerance observed in plant cells might represent a valuable tool to investigate the events underlying the low dose (LD) response in the highly radio-sensitive animal cells. The use of radio-resistant plant systems would allow investigation of the LD effects using irradiation conditions that can be easily managed, without the technical constrains currently encountered with animal systems. The basal knowledge on the molecular mechanisms involved in the DNA damage response in plants is rapidly expanding, revealing common features with animal cells at the level of DNA damage sensing/repair, transduction pathways and antioxidant response. The present work provides a short update of the current literature dealing with the DNA damage response in animal and plant cells exposed to LD treatments (ionising radiation, particularly gamma ray) combined with the more recent advances in free radical research.
authors.affiliation: Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, via Ferrata 1, Pavia 27100, Italy alma.balestrazzi@unipv.it.
authors.forename: Alma
authors.initials: A
authors.lastname: Balestrazzi
authors.affiliation: Consiglio per la Ricerca e la Sperimentazione in Agricoltura, Unità di Ricerca per la Floricoltura e le Specie Ornamentali (CRA-FSO), Corso Inglesi, Sanremo 508-18038, IM, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Giovannini
authors.affiliation: Department of Chemistry, viale Taramelli 16-I, Pavia 27100, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Dondi
authors.affiliation: Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, via Ferrata 1, Pavia 27100, Italy.
authors.forename: Maria Elisa
authors.initials: ME
authors.lastname: Sabatini
authors.affiliation: Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, via Ferrata 1, Pavia 27100, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Carbonera
authors.affiliation: Department of Chemistry, viale Taramelli 16-I, Pavia 27100, Italy.
authors.forename: Armando
authors.initials: A
authors.lastname: Buttafava
mesh_terms: D000818:Animals; D004249:DNA Damage / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects*; D059828:Plant Cells / Q000528:radiation effects*; D011836:Radiation Tolerance; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species