title: A comparative study of 18F-fluorodeoxyglucose positron emission tomography/computed tomography and (99m)Tc-MDP whole-body bone scanning for imaging osteolytic bone metastases.
abstract: BACKGROUND
  The objective of this study was to evaluate the feasibility and diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and (99m)Tc-methylenediphosphonate (MDP) whole-body bone scanning (BS) for the detection of osteolytic bone metastases.
  
  
  METHODS
  Thirty-four patients with pathologically confirmed malignancies and suspected osteolytic bone metastases underwent 18F-FDG PET/CT and (99m)Tc-MDP whole-body BS within 30 days. The sensitivity, specificity, and accuracy with respect to the diagnosis of osteolytic bone metastases and bone lesions were compared between the two imaging methods.
  
  
  RESULTS
  The sensitivity, specificity, and accuracy of 18F-FDG PET/CT for the diagnosis of osteolytic bone metastases were 94.3% (95% confidence interval [CI], 91.6-96.2%), 83.3% (95% CI, 43.6-96.9%), and 94.2% (95% CI, 91.5-96.1%), respectively. It was found that (99m)Tc-MDP whole-body BS could discriminate between patients with 50.2% (95% CI, 45.4-55.1%) sensitivity, 50.0% (95% CI, 18.8-81.2%) specificity, and 50.2% (95% CI, 45.5-55.1%) accuracy. 18F-FDG PET/CT achieved higher sensitivity, specificity, and accuracy in detecting osteolytic bone metastases than 99mTc-MDP whole-body BS (p<0.001).
  
  
  CONCLUSIONS
  F-FDG PET/CT has a higher diagnostic value than (99m)Tc-MDP whole-body BS in the detection of osteolytic bone metastases, especially in the vertebra.
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. linzhangswh@yahoo.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. clhaaa2002@163.com.|Department of Radiology, Taihu Hospital, Jiangsu Province, Wuxi, 214044, China. clhaaa2002@163.com.
authors.forename: Lihua
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. 847179451@qq.com.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Xie
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. xray_zhang@126.com.
authors.forename: Yongke
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. chenglin_0916@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. haitaoli@gmail.com.
authors.forename: Haitao
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China. wangjian_811@yahoo.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000556:secondary*; D005240:Feasibility Studies; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000175:diagnosis* / Q000209:etiology; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed / Q000379:methods; D051598:Whole Body Imaging / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D013669:Technetium Tc 99m Medronate