title: Ten-year stability of self-reported schizotypal personality features in patients with psychosis and their healthy siblings.
abstract: Schizotypal personality disorder (SPD) symptoms or features are common in patients with psychosis and their healthy relatives. However, the long-term stability of these SPD features and therefore their constituting enduring traits underlying vulnerability to psychosis remain to be clarified. Thirty-two patients with psychotic disorders and 29 of their healthy siblings were included from the long-term follow-up study of 89 nuclear families. Participants were clinically assessed by means of a semi-structured diagnostic interview, whereas the Schizotypal Personality Questionnaire-Brief (SPQ-B) was applied for the self-assessment of SPD symptoms. The assessments were carried out upon admission to the study and at follow-up, about 10 years later. The patients had higher scores than their siblings on the SPQ-B both at baseline and follow-up. In addition, self-reported SPD symptoms remained stable over time in total scores and in all the SPQ-B subscores, except for the SPQ-B Disorganization subscale. Self-reported SPD symptoms were stable over the long term among patients with psychotic disorders and their healthy siblings. This finding provides new support for including the SPD construct as a trait measure for studies addressing both vulnerability to psychosis in first-degree relatives of patients with psychosis and long-term persistence of symptoms in patients suffering from psychosis.
authors.affiliation: Psychiatric Unit B, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Moreno-Izco
authors.affiliation: Psychiatric Unit B, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Sánchez-Torres
authors.affiliation: Psychiatric Unit B, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: Ruth
authors.initials: R
authors.lastname: Lorente-Omeñaca
authors.affiliation: Unitat d'Antropologia, Departament Biologia Animal, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Universitat de Barcelona, Barcelona, Spain.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Fañanás
authors.affiliation: Unitat d'Antropologia, Departament Biologia Animal, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Universitat de Barcelona, Barcelona, Spain.
authors.forename: Araceli
authors.initials: A
authors.lastname: Rosa
authors.affiliation: International Consortium for Bipolar and Psychotic Disorders Research, Department of Psychiatry, McLean Hospital-Harvard Medical School, Belmont, MA, United States; Section of Psychiatry, Department of Neuroscience, University of Parma, Parma, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Salvatore
authors.affiliation: Psychiatric Unit B, Complejo Hospitalario de Navarra, Pamplona, Spain.
authors.forename: Victor
authors.initials: V
authors.lastname: Peralta
authors.affiliation: Psychiatric Unit B, Complejo Hospitalario de Navarra, Pamplona, Spain. Electronic address: mcuestaz@cfnavarra.es.
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Cuesta
mesh_terms: D000328:Adult; D010054:Brief Psychiatric Rating Scale / Q000592:standards; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology*; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000235:genetics / Q000523:psychology*; D057566:Self Report / Q000592:standards*; D012647:Self-Assessment; D035781:Siblings / Q000523:psychology*
keywords: Personality disorders; Psychosis; Relatives; Schizophrenia