title: Effect of inhaled fluticasone propionate on retinal nerve fiber layer thickness in asthmatic children.
abstract: OBJECTIVE
  Corticosteroids are under suspicion of playing an important role in the development of retinopathy. We aimed to determine peripapillary retinal nerve fiber layer (RNFL) thinning by spectral-domain optical coherence tomography (OCT) in children being treated with inhaled fluticasone propionate due to asthma.
  
  
  METHODS
  Thirty-eight children diagnosed with allergic asthma (mean age 9.8 ± 2.8 years, age range 6-13 years) and 40 age-similar controls were enrolled in this study. All children with asthma were taking inhaled fluticasone propionate at a dosage of 250 µg or more per day for at least 1 year. The RNFL thickness measurements were performed using Cirrus HD spectral-domain OCT 400. Central subfield thickness, cube average thickness, and cube volume were also measured.
  
  
  RESULTS
  Among the 38 children with asthma and 40 healthy subjects who completed follow-up, children with asthma had similar mean peripapillary RNFL thicknesses compared with control children. The mean central subfield thickness was significantly higher than that of controls (248.8 ± 23.4 vs 237.5 ± 23.5, p&lt;0.037). There was a positive linear relationship between cube average thickness and eosinophil count with a Pearson correlation coefficient of 0.336 (p&lt;0.039) and a negative correlation was found between central subfield thickness and disease duration (r = -0.385, p = 0.017) in children with asthma.
  
  
  CONCLUSIONS
  Asthmatic children have similar peripapillary RNFL measurements compared to controls on spectral-domain OCT. Raised eosinophil counts in asthmatic children were found to be significantly associated with cube average thickness.
authors.affiliation: Department of Pediatrics, S. Demirel University, Faculty of Medicine, Isparta - Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Dereci
authors.affiliation: Department of Pediatrics, S. Demirel University, Faculty of Medicine, Isparta - Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Pirgon
authors.affiliation: Department of Pediatrics, S. Demirel University, Faculty of Medicine, Isparta - Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Akcam
authors.affiliation: Department of Ophthalmology, R.T. Erdogan University, Faculty of Medicine, Rize - Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Turkyilmaz
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Katip Celebi University, Izmir - Turkey.
authors.forename: Bumin
authors.initials: B
authors.lastname: Dundar
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D018926:Anti-Allergic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D004804:Eosinophils / Q000166:cytology; D005260:Female; D000068298:Fluticasone / Q000008:administration & dosage*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology; D012160:Retina / Q000187:drug effects; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods
chemical_list: D018926:Anti-Allergic Agents; D007073:Immunoglobulin E; D000068298:Fluticasone