title: Effect of Diprotin A, an Inhibitor of Dipeptidyl Peptidase IV, on Immunological Parameters of Lymphocytes in Intact Animals and Animals with Experimental Autoimmune Process.
abstract: We found the peculiarities of the effects of dipeptidyl peptidase IV inhibitor diprotin A on immunological parameters of lymphocytes in lymphoid organs in intact animals and in animals with experimental autoimmune process. In intact animals, diprotin A increased cellularity of the thymus and spleen, number of CD4+, CD8+, and CD4+8+ thymocytes and CD3+ splenocytes and reduced cellularity of lymph nodes and the number of antibody-forming cells in the spleen. Diprotin A administered against the background of autoimmune process, reduced thymus cellularity, number of antibody-forming cells in the spleen, and number of CD4 and CD4+8+ thymocytes in comparison with the corresponding parameters of autoimmune process.
authors.affiliation: Research Institute of Clinical and Experimental Lymphology, Siberian, Russia, robin@physiol.ru.
authors.forename: M V
authors.initials: MV
authors.lastname: Robinson
authors.forename: E V
authors.initials: EV
authors.lastname: Mel'nikova
authors.forename: V A
authors.initials: VA
authors.lastname: Trufakin
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000187:drug effects*; D017252:CD3 Complex / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology
chemical_list: D017252:CD3 Complex; D054873:Dipeptidyl-Peptidase IV Inhibitors; D009842:Oligopeptides; C041445:diprotin A