title: Endovascular treatment of acute ischemic stroke.
abstract: Endovascular therapy for acute stroke has evolved with the use of intra-arterial thrombolytics, intravenous/intra-arterial bridging strategies, and mechanical thrombectomy/aspiration devices. Despite widespread use in clinical practice, randomized trials of first-generation devices failed to demonstrate improved outcomes compared with standard care. New-generation stent retriever devices demonstrate higher rates of revascularization and clinical outcomes compared with first-generation devices. Additional randomized trials are underway and have the potential to confirm clinical efficacy of new-generation devices compared with standard care. The role of additional advanced imaging for patient selection remains unclear, and further trials are needed to demonstrate the role of these techniques for patient selection.
authors.affiliation: Department of Neurology, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724-5023, USA. Electronic address: ckidwell@email.arizona.edu.
authors.forename: Chelsea S
authors.initials: CS
authors.lastname: Kidwell
authors.affiliation: Division of Interventional Neuroradiology, Department of Radiology, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Suite 2129, Los Angeles, CA 90095-7437, USA.
authors.forename: Reza
authors.initials: R
authors.lastname: Jahan
mesh_terms: D057510:Endovascular Procedures / Q000379:methods*; D006801:Humans; D059906:Neuroimaging / Q000379:methods; D020521:Stroke / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000379:methods*
keywords: Acute ischemic stroke; Computed tomography; Endovascular; MRI; Neuroimaging; Penumbra; Thrombolysis