title: MicroRNAs as biomarkers for graft-versus-host disease following allogeneic stem cell transplantation.
abstract: Allogeneic hematopoietic stem cell transplantation (HCT) is a well-established treatment for many malignant and non-malignant hematological disorders. As frequent complication in up to 50 % of all patients, graft-versus-host disease (GVHD) is still the main cause for morbidity and non-relapse mortality. Diagnosis of GVHD is usually done clinically, even though confirmation by pathology is often used to support the clinical findings. Effective treatment requires intensified immunosuppression as early as possible. Although several promising biomarkers have been proposed for an early diagnosis, no internationally recognized consensus has yet been established. Here, microRNAs (miRs) represent an interesting tool since miRs have been recently reported to be an important regulator of various cells, including immune cells such as T cells. Therefore, we could assume that miRs play a key role in the pathogenesis of acute GVHD, and their detection might be an interesting possibility in the early diagnosis and monitoring of acute GVHD. Recent studies additionally demonstrated the implication of miRs in the pathogenesis of acute GVHD. In this review, we aim to summarize the previous reports of miRs, focusing on the pathogenesis of acute GVHD and possible implications in diagnostic approaches.
authors.affiliation: Iuliu Hatieganu University of Medicine and Pharmacy, Bulevardul 21 Decembrie 1918 Nr. 73, 400124, Cluj Napoca, Romania, ciprian.tomuleasa@umfcluj.ro.
authors.forename: Ciprian
authors.initials: C
authors.lastname: Tomuleasa
authors.forename: Shigeo
authors.initials: S
authors.lastname: Fuji
authors.forename: Andrei
authors.initials: A
authors.lastname: Cucuianu
authors.forename: Markus
authors.initials: M
authors.lastname: Kapp
authors.forename: Valentina
authors.initials: V
authors.lastname: Pileczki
authors.forename: Bobe
authors.initials: B
authors.lastname: Petrushev
authors.forename: Sonia
authors.initials: S
authors.lastname: Selicean
authors.forename: Alina
authors.initials: A
authors.lastname: Tanase
authors.forename: Delia
authors.initials: D
authors.lastname: Dima
authors.forename: Ioana
authors.initials: I
authors.lastname: Berindan-Neagoe
authors.forename: Alexandru
authors.initials: A
authors.lastname: Irimie
authors.forename: Hermann
authors.initials: H
authors.lastname: Einsele
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D033581:Stem Cell Transplantation / Q000009:adverse effects* / Q000639:trends; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000639:trends
chemical_list: D015415:Biomarkers; D035683:MicroRNAs