title: [Congenital bilateral absence of vas deferens: From diagnosis to assisted reproductive techniques - the experience of three centers].
abstract: OBJECTIVE
  To review the management with assisted reproductive technologies (ART) of men with congenital bilateral absence of vas deferens (CBAVD), associated with cystic fibrosis or not, after surgical retrieval [epididymal aspiration (MESA) or testicular biopsy (TESE)].
  
  
  METHODS
  Multicenter retrospective study made of 2 groups: CBAVD and cystic fibrosis (CF) or CBAVD only (CF-RD). Two centers performed MESA (Brest and Nantes) and one TESE (Rennes). Sperm numeration, motility, vitality, morphology and nuclear maturity were measured in both centers performing MESA. Fertilization rate (TF) and cumulated progressive pregnancy rate by retrieved oocyte (TGC) were compared between centers following ART.
  
  
  RESULTS
  Ninety patients underwent surgical retrieval between January 1996 and March 2013, 30 in the CF group and 60 in the CF-RD group. Semen parameters were comparable between groups and centers. Fifty-eight (22 in the CF group and 36 in the CF-RD group) patients received ART between April 1996 and October 2014. TF was 50% and 52% and TGC 26% and 32% in the CF group and CF-RD groups, respectively. The results did not differ between groups but TGC was higher in Rennes than in the other two centers.
  
  
  CONCLUSIONS
  Both semen parameters and ART results are comparable and similar to those reported in the literature. As shown by the results obtained in Rennes, TESE seems to be more effective.
authors.affiliation: Faculté de médecine et des sciences de la santé, université de Brest, 22, rue Camille-Desmoulins, 29200 Brest, France; Service de cytogénétique et de biologie de la reproduction, hôpital Morvan, CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France. Electronic address: damien.beauvillard@chu-brest.fr.
authors.forename: D
authors.initials: D
authors.lastname: Beauvillard
authors.affiliation: Faculté de médecine et des sciences de la santé, université de Brest, 22, rue Camille-Desmoulins, 29200 Brest, France; Service de cytogénétique et de biologie de la reproduction, hôpital Morvan, CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France; Institut national de la santé et de la recherche médicale (Inserm), U1078, 46, rue Félix-Le-Dantec, CS51819 Brest cedex 2, France.
authors.forename: A
authors.initials: A
authors.lastname: Perrin
authors.affiliation: Service de biologie de la reproduction-CECOS, hôpital Sud, CHU de Rennes, 2, boulevard de Bulgarie, 35200 Rennes, France.
authors.forename: H
authors.initials: H
authors.lastname: Drapier
authors.affiliation: Service de biologie de la reproduction-CECOS, hôpital Sud, CHU de Rennes, 2, boulevard de Bulgarie, 35200 Rennes, France.
authors.forename: C
authors.initials: C
authors.lastname: Ravel
authors.affiliation: Service de biologie de la reproduction-CECOS, hôpital Mère-Enfant, CHU de Nantes, 7, quai Montcousu, 44093 Nantes, France.
authors.forename: T
authors.initials: T
authors.lastname: Fréour
authors.affiliation: Faculté de médecine et des sciences de la santé, université de Brest, 22, rue Camille-Desmoulins, 29200 Brest, France; Institut national de la santé et de la recherche médicale (Inserm), U1078, 46, rue Félix-Le-Dantec, CS51819 Brest cedex 2, France; Laboratoire de génétique moléculaire et histocompatibilité, hôpital Morvan, CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Férec
authors.affiliation: Faculté de médecine et des sciences de la santé, université de Brest, 22, rue Camille-Desmoulins, 29200 Brest, France; Service de cytogénétique et de biologie de la reproduction, hôpital Morvan, CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France; Institut national de la santé et de la recherche médicale (Inserm), U1078, 46, rue Félix-Le-Dantec, CS51819 Brest cedex 2, France.
authors.forename: M
authors.initials: M
authors.lastname: De Braekeleer
authors.affiliation: Service de cytogénétique et de biologie de la reproduction, hôpital Morvan, CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Amice
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000628:therapy; D008297:Male; D052801:Male Urogenital Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D055101:Semen Analysis; D014649:Vas Deferens / Q000002:abnormalities*
keywords: Absence bilatérale des canaux déférents; Aspiration épididymaire; Assistance médicale à la procréation; Assisted reproductive technologies; Biopsie testiculaire; Congenital bilateral absence of vas deferens; Cystic fibrosis; Epididymal aspiration; Mucoviscidose; Testicular biopsy