title: Epilepsy of infancy with migrating focal seizures: three patients treated with the ketogenic diet.
abstract: We present three patients with epilepsy of infancy with migrating focal seizures treated with the ketogenic diet. Between February 1, 2012 and January 31, 2014, three patients who met the diagnostic criteria for migrating focal seizures in infancy at our department were placed on the ketogenic diet and followed for a minimum of seven months. Two of the three children responded well to the ketogenic diet. One of these patients became seizure-free and his neuropsychological performance also significantly improved. The other child had a seizure reduction of 75% to 99% with only weekly seizures and moderate psychomotor improvement. For these two patients who responded well to the ketogenic diet, hospital admission was not required. The remaining patient had a seizure reduction of less than 50%. Tolerability of the diet was good in all three patients. Early treatment with the ketogenic diet should be considered for epilepsy of infancy with migrating focal seizures to control seizures and status epilepticus, and avoid progressive cognitive impairment.
authors.affiliation: Neurology Department, Pediatric Hospital "Prof. Dr. Juan P. Garrahan", Buenos Aires.
authors.forename: Roberto
authors.initials: R
authors.lastname: Caraballo
authors.affiliation: Neurology Department, Pediatric Hospital "Humberto Notti", Mendoza.
authors.forename: Daniel
authors.initials: D
authors.lastname: Noli
authors.affiliation: Neurology Department, Pediatric Hospital "Victor J Vilela", Rosario, Argentina.
authors.forename: Pedro
authors.initials: P
authors.lastname: Cachia
mesh_terms: D002675:Child, Preschool; D055423:Diet, Ketogenic / Q000379:methods*; D004351:Drug Resistance; D004828:Epilepsies, Partial / Q000178:diet therapy*; D020936:Epilepsy, Benign Neonatal / Q000178:diet therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016896:Treatment Outcome
keywords: epileptic encephalopathy; infant; ketogenic diet; migrating seizure; refractory epilepsy