title: [Treatment of hypertensive emergencies and malignant hypertension: the possibility of using urapidil].
abstract: The review considers the possibility of using parenteral urapidil for treatment of hypertensive crises. The drug having a dual mechanism of action and properties of combining α-blocker and a centrally acting drug, has a high efficiency, comparable to that of the other groups of drugs, and a good tolerability. In a review of the features of the mechanism of action of the drug, its pharmacokinetics and pharmacodynamics. The data key studies demonstrating the features of the antihypertensive action of parenteral urapidil. Detailed proof of the effectiveness of urapidil in complicated and uncomplicated hypertensive crisis, the treatment of perioperative hypertension, treatment of hypertension in patients with pheochromocytoma and in pregnant women with preeclampsia.
authors.forename: L O
authors.initials: LO
authors.lastname: Minushkina
mesh_terms: D000959:Antihypertensive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D004638:Emergency Treatment / Q000379:methods; D005260:Female; D006801:Humans; D006974:Hypertension, Malignant / Q000188:drug therapy / Q000209:etiology; D010879:Piperazines / Q000493:pharmacokinetics / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; C015568:urapidil