title: Effectiveness of prolonged clopidogrel-based dual antiplatelet therapy after drug-eluting stent implantation: Evidence-based meta-analysis.
abstract: The use of drug-eluting stents (DESs) for patients with coronary artery disease is widespread. DESs have been associated with a lower rate of repeat revascularization, death, and myocardial infarction compared with bare metal stents. However, DESs can lead to a prothrombotic environment in the coronary arteries, resulting in a higher rate of thrombotic events. To counteract this, dual-antiplatelet therapy (DAPT) consisting of aspirin and clopidogrel is recommended. Currently, there are no clear guidelines on the duration of DAPT. We therefore conducted a meta-analysis to assess the effectiveness of prolonged DAPT after DES implantation.
authors.affiliation: Department of Critical Care Medicine, The First Peoples Hospital of Shunde, No.1 Penglai Rd. Foshan, 528300, Foshan, P.R. China.
authors.forename: Changzhi
authors.initials: C
authors.lastname: Liu
authors.forename: Mao
authors.initials: M
authors.lastname: Liu
authors.forename: Dezhu
authors.initials: D
authors.lastname: Chen
authors.forename: Haifeng
authors.initials: H
authors.lastname: Liu
authors.forename: Qianhua
authors.initials: Q
authors.lastname: Jiang
authors.forename: Jianhai
authors.initials: J
authors.lastname: Lu
authors.forename: Liuer
authors.initials: L
authors.lastname: Zuo
mesh_terms: D000368:Aged; D001241:Aspirin / Q000008:administration & dosage; D000077144:Clopidogrel; D023903:Coronary Restenosis / Q000401:mortality* / Q000517:prevention & control*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D054855:Drug-Eluting Stents / Q000706:statistics & numerical data*; D019317:Evidence-Based Medicine; D005260:Female; D006083:Graft Occlusion, Vascular / Q000401:mortality* / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D015995:Prevalence; D012307:Risk Factors; D015996:Survival Rate; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin