title: Serum omentin, resistin and tumour necrosis factor-α levels in Behcet patients with and without ocular involvement.
abstract: OBJECTIVE
  The objective of this study was to evaluate serum omentin, resistin and tumour necrosis factor-α (TNF-α) levels in Behcet disease (BD) patients with and without ocular involvement, as well as control subjects.
  
  
  METHODS
  Omentin, resistin and TNF-α levels were assessed in the plasma of 51 BD patients and compared with those of 24 control subjects.
  
  
  RESULTS
  The plasma resistin and TNF-α levels were significantly higher in the BD patients than in the control group (p = 0.028 and p = 0.011, respectively), whereas the plasma omentin level was significantly lower in BD patients than in the control group (p = 0.035). In the ocular BD, non-ocular BD and control groups, the omentin levels were 8.9 ± 4.65, 8.6 ± 3.61, and 12.4 ± 6.24 ng/mL; resistin levels were 0.29 ± 0.21, 0.24 ± 0.2 and 0.15 ± 0.45 ng/mL; and TNF-α levels were 25.45 ± 3.65, 24.03 ± 2.49 and 21.93 ± 4.86 ng/mL, respectively. Omentin/resistin and TNF-α/omentin ratios were more significant parameters in the demonstration of the differences in the groups; the former was lower and the latter was higher in the patient groups (p = 0.001 and p = 0.002, respectively).
  
  
  CONCLUSIONS
  We demonstrated that the plasma omentin level and omentin/resistin ratio were decreased, whereas the resistin and TNF-α levels and TNF-α/omentin ratio were increased in BD patients. These ratios may be used in the presentation of deviation in the inflammatory and anti-inflammatory balance in BD.
authors.affiliation: Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakir, Turkey, turkcufm@gmail.com.
authors.forename: Fatih Mehmet
authors.initials: FM
authors.lastname: Türkcü
authors.forename: Alparslan
authors.initials: A
authors.lastname: Şahin
authors.forename: Abdullah Kürşat
authors.initials: AK
authors.lastname: Cingü
authors.forename: Savaş
authors.initials: S
authors.lastname: Kaya
authors.forename: Hatice
authors.initials: H
authors.lastname: Yüksel
authors.forename: Yasin
authors.initials: Y
authors.lastname: Cinar
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Batmaz
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000097:blood* / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D052243:Resistin / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D014605:Uveitis / Q000097:blood* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; C499624:RETN protein, human; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha