title: Iron Oxide@PEDOT-Based Recyclable Photothermal Nanoparticles with Poly(vinylpyrrolidone) Sulfobetaines for Rapid and Effective Antibacterial Activity.
abstract: Growing microbial resistance that renders antibiotic treatment vulnerable has emerged, attracting a great deal of interest in the need to develop alternative antimicrobial treatments. To contribute to this effort, we report magnetic iron oxide (Fe3O4) nanoparticles (NPs) coated with catechol-conjugated poly(vinylpyrrolidone) sulfobetaines (C-PVPS). This negatively charged Fe3O4@C-PVPS is subsequently encapsulated by poly(3,4-ethylenedioxythiophene) (PEDOT) following a layer-by-layer (LBL) self-assembly method. The obtained Fe3O4@C-PVPS:PEDOT nanoparticles appear to be novel NIR-irradiated photothermal agents that can achieve effective bacterial killing and are reusable after isolation of the used particles using external magnetic fields. The recyclable Fe3O4@C-PVPS:PEDOT NPs exhibit a high efficiency in converting photothermal heat for rapid antibacterial effects against Staphylococcus aureus and Escherichia coli. In this study, antibacterial tests for repeated uses maintained almost 100% antibacterial efficiency during three cycles and provided rapid and effective killing of 99% Gram-positive and -negative bacteria within 5 min of near-infrared (NIR) light exposure. The core-shell nanoparticles (Fe3O4@C-PVPS:PEDOT) exhibit the required stability, and their paramagnetic nature means that they rapidly convert photothermal heat sufficient for use as NIR-irradiated antibacterial photothermal sterilizing agents.
authors.forename: Chan Jin
authors.initials: CJ
authors.lastname: Jeong
authors.affiliation: ‡Department of Chemistry, KAIST, Daejeon 305-701, Republic of Korea.
authors.forename: Shazid Md
authors.initials: SM
authors.lastname: Sharker
authors.forename: Insik
authors.initials: I
authors.lastname: In
authors.forename: Sung Young
authors.initials: SY
authors.lastname: Park
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001622:Betaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005290:Ferric Compounds / Q000737:chemistry*; D007259:Infrared Rays; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D055668:Photochemical Processes; D056951:Photoelectron Spectroscopy; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D011205:Povidone / Q000494:pharmacology*; D059027:Recycling; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects; D013696:Temperature; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005290:Ferric Compounds; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene); C000499:ferric oxide; D001622:Betaine; C483727:sulfobetaine; D011205:Povidone
keywords: PEDOT; antibacterial activity; iron oxide; near-infrared; photothermal; recyclable