title: In vivo biocompatibility of Mg implants surface modified by nanostructured merwinite/PEO.
abstract: Magnesium (Mg) alloys have been suggested as biodegradable bone implant materials due to their good intrinsic biocompatibility and great mechanical properties. Although magnesium has attractive properties as an orthopedic implant material, its quick degradation and low bioactivity may lead to the loss of mechanical integrity of the implant during the bone healing process. In this paper, we endeavor to surmount the abovementioned defects using the surface coating technique. We have recently coated AZ91 magnesium implants with merwinite (Ca3MgSi2O8) through the coupling of plasma electrolytic oxidation (PEO) and electrophoretic deposition method. In this work, we are specifically focused on the in vivo examinations of the coated implants in comparison with the uncoated one. For the in vivo experiment, the rod samples, including the uncoated and merwinite/PEO coated implants, were imbedded into the greater trochanter of rabbits. The results of the in vivo animal test indicated an improvement in biodegradability including slower implant weight loss, reduction in Mg ion released from the coated implants in the blood plasma, lesser release of hydrogen bubbles and an improvement in biocompatibility including an increase in the amount of bone formation and ultimately a mild bone inflammation after the surgery according to the histological images. In summary, proper surface treatment of magnesium implants such as silicate bioactive ceramics may improve their biocompatibility under physiological conditions to making them suitable and applicable for future clinical applications.
authors.affiliation: Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, 84156-83111, Isfahan, Iran, mrazavi2659@gmail.com.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Razavi
authors.forename: Mohammadhossein
authors.initials: M
authors.lastname: Fathi
authors.forename: Omid
authors.initials: O
authors.lastname: Savabi
authors.forename: Daryoosh
authors.initials: D
authors.lastname: Vashaee
authors.forename: Lobat
authors.initials: L
authors.lastname: Tayebi
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000627:therapeutic use; D000069343:Bone-Implant Interface; D002516:Ceramics / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000627:therapeutic use; D004595:Electroplating; D019544:Equipment Failure Analysis; D005264:Femoral Fractures / Q000473:pathology / Q000628:therapy*; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use / Q000648:ultrastructure; D058626:Plasma Gases / Q000737:chemistry; D019736:Prostheses and Implants; D011474:Prosthesis Design; D011817:Rabbits; D013499:Surface Properties; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D058626:Plasma Gases; D008274:Magnesium