title: Neurofilaments and traumatic brain injury.
abstract: Objective determination of the time of brain contusion is of key importance in medicolegal neurotraumatology. Currently, the progress of immunohistochemistry allows the study of structural elements of cells including neurofilaments, i.e. neuronal cytoskeletal proteins possessing properties that could be used for determining the age of brain injury in forensic medicine. The purpose of this study was to review recently published literature with a focus on studies investigating changes which occur in neurofilaments after brain trauma, both in animal models and in human biological material. The review has shown a lack of data on temporal changes in neurofilament expression after human brain trauma which could be used for determining the age of injuries in forensic medicine.
authors.affiliation: Mariusz Kobek, PhD, MD, Chair and Department of Forensic, Medicine and Medicolegal Toxicology, Medical University of Silesia in Katowice, Medyków 18, 40-752 Katowice, Poland, e-mail: mariusz.kobek@wp.pl.
authors.forename: M
authors.initials: M
authors.lastname: Kobek
authors.forename: R
authors.initials: R
authors.lastname: Skowronek
authors.forename: Z
authors.initials: Z
authors.lastname: Jankowski
authors.forename: A
authors.initials: A
authors.lastname: Pałasz
mesh_terms: D001921:Brain / Q000378:metabolism* / Q000473:pathology; D020833:Diffuse Axonal Injury / Q000378:metabolism* / Q000473:pathology; D005554:Forensic Medicine; D006801:Humans; D007150:Immunohistochemistry; D016900:Neurofilament Proteins / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D016900:Neurofilament Proteins