title: Multifaceted prospects of nanocomposites for cardiovascular grafts and stents.
abstract: Cardiovascular disease is the leading cause of death across the globe. The use of synthetic materials is indispensable in the treatment of cardiovascular disease. Major drawbacks related to the use of biomaterials are their mechanical properties and biocompatibility, and these have to be circumvented before promoting the material to the market or clinical setting. Revolutionary advancements in nanotechnology have introduced a novel class of materials called nanocomposites which have superior properties for biomedical applications. Recently, there has been a widespread recognition of the nanocomposites utilizing polyhedral oligomeric silsesquioxane, bacterial cellulose, silk fibroin, iron oxide magnetic nanoparticles, and carbon nanotubes in cardiovascular grafts and stents. The unique characteristics of these nanocomposites have led to the development of a wide range of nanostructured copolymers with appreciably enhanced properties, such as improved mechanical, chemical, and physical characteristics suitable for cardiovascular implants. The incorporation of advanced nanocomposite materials in cardiovascular grafts and stents improves hemocompatibility, enhances antithrombogenicity, improves mechanical and surface properties, and decreases the microbial response to the cardiovascular implants. A thorough attempt is made to summarize the various applications of nanocomposites for cardiovascular graft and stent applications. This review will highlight the recent advances in nanocomposites and also address the need of future research in promoting nanocomposites as plausible candidates in a campaign against cardiovascular disease.
authors.affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
authors.forename: Muthu Vignesh
authors.initials: MV
authors.lastname: Vellayappan
authors.affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
authors.forename: Arunpandian
authors.initials: A
authors.lastname: Balaji
authors.affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
authors.forename: Aruna Priyadarshini
authors.initials: AP
authors.lastname: Subramanian
authors.affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
authors.forename: Agnes Aruna
authors.initials: AA
authors.lastname: John
authors.affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
authors.forename: Saravana Kumar
authors.initials: SK
authors.lastname: Jaganathan
authors.affiliation: Rubber Technology Center, Indian Institute of Technology, Kharagpur, India.
authors.forename: Selvakumar
authors.initials: S
authors.lastname: Murugesan
authors.affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
authors.forename: Eko
authors.initials: E
authors.lastname: Supriyanto
authors.affiliation: IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yusof
mesh_terms: D001807:Blood Vessel Prosthesis; D002318:Cardiovascular Diseases / Q000628:therapy*; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry*; D015607:Stents
keywords: cardiovascular biomaterials; hemocompatibility; nanocomposites; nanoparticles; stents; vascular grafts