title: The ABC of Phytohormone Translocation.
abstract: ATP-driven transport across biological membranes is a key process to translocate solutes from the interior of the cell to the extracellular environment. In humans, ATP-binding cassette transporters are involved in absorption, distribution, metabolism, excretion, and toxicity, and also play a major role in anticancer drug resistance. Analogous transporters are also known to be involved in phytohormone translocation. These include, e.g., the transport of auxin by ABCB1/19 in Arabidopsis thaliana, the transport of abscisic acid by AtABCG25, and the transport of strigolactone by the Petunia hybrida ABC transporter PDR1. Within this article, we outline the current knowledge about plant ABC transporters with respect to their structure and function, and provide, for the first time, a protein homology model of the strigolactone transporter PDR1 from P. hybrida.
authors.affiliation: University of Vienna, Department of Pharmaceutical Chemistry, Vienna, Austria.
authors.forename: Eva
authors.initials: E
authors.lastname: Hellsberg
authors.affiliation: University of Vienna, Department of Pharmaceutical Chemistry, Vienna, Austria.
authors.forename: Floriane
authors.initials: F
authors.lastname: Montanari
authors.affiliation: University of Vienna, Department of Pharmaceutical Chemistry, Vienna, Austria.
authors.forename: Gerhard F
authors.initials: GF
authors.lastname: Ecker
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000378:metabolism*; D001692:Biological Transport; D008958:Models, Molecular; D010937:Plant Growth Regulators / Q000378:metabolism*; D011487:Protein Conformation
chemical_list: D018528:ATP-Binding Cassette Transporters; D010937:Plant Growth Regulators