title: Metaplastic breast cancer in a patient with neurofibromatosis.
abstract: Metaplastic breast cancer is a rare malignancy in the breast. Neurofibromatosis Type 1 is an autosomal dominant multisystem disorder associated with multiple neoplasms such as optic gliomas and peripheral nerve sheath tumors. The association of breast cancer with neurofibromatosis is very rare. We present a case of a metaplastic breast cancer in a patient with Type 1 neurofibromatosis. The patient presented with a palpable mass in her left breast with suspicious findings on mammogram and ultrasound. Ultrasound-guided percutaneous biopsy showed metaplastic breast carcinoma with metastasis to an axillary lymph node. This is the third case report in the English literature to show metaplastic breast carcinoma in a patient with Type 1 neurofibromatosis. In this report we review recent literature and discuss the association between these two entities.
authors.affiliation: Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
authors.forename: Umar Shafique
authors.initials: US
authors.lastname: Chaudhry
authors.affiliation: Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
authors.forename: Limin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Pathology, Sanford School of Medicine, The University of South Dakota, Sioux Falls, South Dakota, USA.
authors.forename: Ryan W
authors.initials: RW
authors.lastname: Askeland
authors.affiliation: Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
authors.forename: Laurie L
authors.initials: LL
authors.lastname: Fajardo
keywords: Breast imaging; metaplastic breast carcinoma; neurofibromatosis