title: Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus.
abstract: Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.
authors.affiliation: AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA; Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Shuya
authors.initials: S
authors.lastname: Yano
authors.affiliation: AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA.
authors.forename: Shinji
authors.initials: S
authors.lastname: Miwa
authors.affiliation: Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kishimoto
authors.affiliation: AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA.
authors.forename: Makoto
authors.initials: M
authors.lastname: Toneri
authors.affiliation: AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA.
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Hiroshima
authors.affiliation: AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA.
authors.forename: Mako
authors.initials: M
authors.lastname: Yamamoto
authors.affiliation: Department of Surgery, University of California San Diego, San Diego, California, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Bouvet
authors.affiliation: Oncolys BioPharm Inc., Tokyo, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Urata
authors.affiliation: Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tazawa
authors.affiliation: Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kagawa
authors.affiliation: Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Toshiyoshi
authors.initials: T
authors.lastname: Fujiwara
authors.affiliation: AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA. Electronic address: all@anticancer.com.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Hoffman
mesh_terms: D000256:Adenoviridae; D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D018572:Disease-Free Survival; D005453:Fluorescence; D005909:Glioblastoma / Q000473:pathology / Q000601:surgery*; D049452:Green Fluorescent Proteins / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D061848:Optical Imaging
chemical_list: D049452:Green Fluorescent Proteins