title: Gastric wall perforation secondary to presumed aspergillosis in a pediatric patient with aplastic anemia: A case report.
abstract: Aspergillosis is an opportunistic fungal infection that may develop in immunocompromised patients with conditions such as leukemia or aplastic anemia. A rare case of stomach perforation following acute fungal gastritis in a 13-year-old female patient with aplastic anemia is reported herein. The patient had developed aplastic anemia without bone marrow fibrosis secondary to acute lymphoblastic leukemia and chemotherapy. The pathological examination revealed a large ischemic transmural perforation (9.5 × 9 cm) associated with fungal septic emboli. Fungal hyphae characteristics were compatible with those of Aspergillus spp. There are few reports identifying fungi as agents associated with gastric perforation. There is a need for early identification of the infectious agent.
authors.affiliation: Central South Hospital from Petroleos Mexicanos, Mexico. jesusreynaf@gmail.com.
authors.forename: Jesus
authors.initials: J
authors.lastname: Reyna-Figueroa
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Luna-Aguilar
authors.forename: Gabriela
authors.initials: G
authors.lastname: Cardoso-Yah
authors.forename: Maria Irene
authors.initials: MI
authors.lastname: Rivera-Salgado
authors.forename: Ana Elena
authors.initials: AE
authors.lastname: Limon-Rojas
authors.forename: Patricia
authors.initials: P
authors.lastname: Galindo-Delgado
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000175:diagnosis*; D001230:Aspergillus / Q000302:isolation & purification*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D016867:Immunocompromised Host; D008853:Microscopy; D010372:Pediatrics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy; D013272:Stomach Diseases / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents