title: SERS-active Au@Ag nanorod dimers for ultrasensitive dopamine detection.
abstract: Dopamine (DA) is a neurotransmitter which plays a key role in the life science. Self-assembled Au@Ag nanorod dimers based on aptamers were developed for ultrasensitive dopamine detection. The electronic field was significantly enhanced by the addition of silver shell coating on the surface of Au NR dimer. The results displayed that Au@Ag NR dimers were ideal building blocks for constructing the SERS substrates with prominent Raman enhancement effects. It was found that with using this Surface-enhanced Raman scattering (SERS)-encoded this sensing system, a limit of detection of 0.006 pM and a wide linear range of 0.01-10 pM for dopamine detection were obtained. Our work open up a new avenue for the diagnosis and drug-discovery programs.
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, PR China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Tang
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, PR China.
authors.forename: Si
authors.initials: S
authors.lastname: Li
authors.affiliation: Cereals & Oils Nutrition Research Group, Academy of Science & Technology of State Administration of Grain, Beijing 100037, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Han
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, PR China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Liu
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, PR China.
authors.forename: Liguang
authors.initials: L
authors.lastname: Xu
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ma
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: Kuang
authors.affiliation: Cereals & Oils Nutrition Research Group, Academy of Science & Technology of State Administration of Grain, Beijing 100037, PR China. Electronic address: lak@chinagrain.org.
authors.forename: Aike
authors.initials: A
authors.lastname: Li
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, PR China.
authors.forename: Libing
authors.initials: L
authors.lastname: Wang
authors.affiliation: State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, PR China. Electronic address: xcl@jiangnan.edu.cn.
authors.forename: Chuanlai
authors.initials: C
authors.lastname: Xu
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D015374:Biosensing Techniques / Q000379:methods; D019281:Dimerization; D004298:Dopamine / Q000032:analysis / Q000097:blood*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D057230:Limit of Detection; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D052157:Aptamers, Nucleotide; D012834:Silver; D006046:Gold; D004298:Dopamine
keywords: Au@Ag nanorod dimers; Detection; Dopamine; SERS