title: Efficacy and safety of creatine supplementation in juvenile dermatomyositis: A randomized, double-blind, placebo-controlled crossover trial.
abstract: BACKGROUND
  It has been suggested that creatine supplementation is safe and effective for treating idiopathic inflammatory myopathies, but no pediatric study has been conducted to date. The objective of this study was to examine the efficacy and safety of creatine supplementation in juvenile dermatomyositis (JDM) patients.
  
  
  METHODS
  In this study, JDM patients received placebo or creatine supplementation (0.1 g/kg/day) in a randomized, crossover, double-blind design. Subjects were assessed at baseline and after 12 weeks. The primary outcome was muscle function. Secondary outcomes included body composition, aerobic conditioning, health-related quality of life, and muscle phosphocreatine (PCr) content. Safety was assessed by laboratory parameters and kidney function measurements.
  
  
  RESULTS
  Creatine supplementation did not affect muscle function, intramuscular PCr content, or any other secondary outcome. Kidney function was not affected, and no side effects were reported.
  
  
  CONCLUSIONS
  Twelve weeks of creatine supplementation in JDM patients were well-tolerated and free of adverse effects, but treatment did not affect muscle function, intramuscular PCr, or any other parameter.
authors.affiliation: School of Medicine, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Marina Yazigi
authors.initials: MY
authors.lastname: Solis
authors.affiliation: School of Medicine, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Hayashi
authors.affiliation: School of Physical Education and Sport, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Guilherme Giannini
authors.initials: GG
authors.lastname: Artioli
authors.affiliation: School of Physical Education and Sport, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Hamilton
authors.initials: H
authors.lastname: Roschel
authors.affiliation: School of Medicine, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Marcelo Tatit
authors.initials: MT
authors.lastname: Sapienza
authors.affiliation: School of Medicine, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Maria Concepción
authors.initials: MC
authors.lastname: Otaduy
authors.affiliation: School of Medicine, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Ana Lucia
authors.initials: AL
authors.lastname: De Sã Pinto
authors.affiliation: School of Medicine, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Clovis Artur
authors.initials: CA
authors.lastname: Silva
authors.affiliation: School of Medicine, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Adriana Maluf Elias
authors.initials: AM
authors.lastname: Sallum
authors.affiliation: School of Medicine, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Rosa Maria R
authors.initials: RM
authors.lastname: Pereira
authors.affiliation: School of Physical Education and Sport, University of São Paulo, Sao Paulo, Brazil.
authors.forename: Bruno
authors.initials: B
authors.lastname: Gualano
mesh_terms: D000293:Adolescent; D001823:Body Composition; D015519:Bone Density; D002648:Child; D003401:Creatine / Q000627:therapeutic use*; D018592:Cross-Over Studies; D016207:Cytokines / Q000097:blood; D003882:Dermatomyositis / Q000178:diet therapy* / Q000473:pathology; D019587:Dietary Supplements; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology; D015444:Exercise; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D011788:Quality of Life; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D064232:Visual Analog Scale; D055815:Young Adult
chemical_list: D016207:Cytokines; D010725:Phosphocreatine; D003401:Creatine
keywords: creatine supplementation; juvenile dermatomyositis; muscle metabolism; phosphocreatine; physical function