title: Diagnostic algorithm for unilateral sinus disease: a 15-year retrospective review.
abstract: BACKGROUND
  Patients presenting with unilateral sinus symptoms or nasal polyps raise concerns about sinister pathology. Yet despite the relatively common occurrence of this presentation, and its potential severity, an organized diagnostic approach to unilateral sinus disease (USD) has never been defined. The purpose of this work was to propose a diagnostic algorithm for managing patients with USD based on prior experience.
  
  
  METHODS
  We performed a retrospective review of the medical records of all patients with USD who underwent surgical intervention and had pathological specimens during a 15-year period at an urban academic center. Nasal endoscopy and computed tomography (CT) scan findings, demographic characteristics, presenting symptoms, medical histories, and previous treatments were analyzed.
  
  
  RESULTS
  A total of 191 patients met the inclusion criteria, 153 of whom were initially diagnosed at our center. Among the latter group, 51 (33%) presented with a nasal mass or polyp observed by endoscopy. Inverted papilloma was present in 16% of those cases, and malignant tumors comprised 14%. In contrast, of patients without an obvious nasal polyp (n = 102), 2% had inverted papilloma and 3% had malignancies. Overall, chronic rhinosinusitis was the most common diagnosis both in patients with polyps (67%) and those without nasal polyps (69%).
  
  
  CONCLUSIONS
  Although USD is most likely to represent chronic inflammation, there exists a fair likelihood of finding malignant pathology, particularly in cases where patients have a unilateral polyp. Based on this review, we propose a strategy for the management of new presentations of USD.
authors.affiliation: Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.
authors.forename: Marianella
authors.initials: M
authors.lastname: Paz Silva
authors.affiliation: Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.
authors.forename: Jayant M
authors.initials: JM
authors.lastname: Pinto
authors.affiliation: Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.
authors.forename: Jacquelynne P
authors.initials: JP
authors.lastname: Corey
authors.affiliation: Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.
authors.forename: Ernest E
authors.initials: EE
authors.lastname: Mhoon
authors.affiliation: Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.
authors.forename: Fuad M
authors.initials: FM
authors.lastname: Baroody
authors.affiliation: Section of Otolaryngology-Head and Neck Surgery, The University of Chicago Medicine and Biological Sciences, Chicago, IL.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Naclerio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000000981:diagnostic imaging* / Q000473:pathology; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods; D018308:Papilloma, Inverted / Q000000981:diagnostic imaging* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D012189:Retrospective Studies; D012220:Rhinitis / Q000000981:diagnostic imaging* / Q000473:pathology; D012852:Sinusitis / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: CT; chronic; endoscopy; fungus; inverted papilloma; sinusitis; unilateral