title: PEDF and its roles in physiological and pathological conditions: implication in diabetic and hypoxia-induced angiogenic diseases.
abstract: Pigment epithelium-derived factor (PEDF) is a broadly expressed multifunctional member of the serine proteinase inhibitor (serpin) family. This widely studied protein plays critical roles in many physiological and pathophysiological processes, including neuroprotection, angiogenesis, fibrogenesis and inflammation. The present review summarizes the temporal and spatial distribution patterns of PEDF in a variety of developing and adult organs, and discusses its functions in maintaining physiological homoeostasis. The major focus of the present review is to discuss the implication of PEDF in diabetic and hypoxia-induced angiogenesis, and the pathways mediating PEDF's effects under these conditions. Furthermore, the regulatory mechanisms of PEDF expression, function and degradation are also reviewed. Finally, the therapeutic potential of PEDF as an anti-angiogenic drug is briefly summarized.
authors.affiliation: *Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Xuemin
authors.initials: X
authors.lastname: He
authors.affiliation: *Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Rui
authors.initials: R
authors.lastname: Cheng
authors.affiliation: *Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Siribhinya
authors.initials: S
authors.lastname: Benyajati
authors.affiliation: *Department of Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Jian-xing
authors.initials: JX
authors.lastname: Ma
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000235:genetics / Q000503:physiopathology*; D005136:Eye Proteins / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D020869:Gene Expression Profiling; D006801:Humans; D000860:Hypoxia; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000235:genetics / Q000502:physiology*; D009414:Nerve Growth Factors / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D015843:Serpins / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D020533:Angiogenesis Inhibitors; D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor