title: Childhood temporal lobe epilepsy: correlation between electroencephalography and magnetic resonance spectroscopy: a case-control study.
abstract: BACKGROUND
  The diagnosis of epilepsy should be made as early as possible to give a child the best chance for treatment success and also to decrease complications such as learning difficulties and social and behavioral problems. In this study, we aimed to assess the ability of magnetic resonance spectroscopy (MRS) in detecting the lateralization side in patients with Temporal lobe epilepsy (TLE) in correlation with EEG and MRI findings.
  
  
  METHODS
  This was a case-control study including 40 patients diagnosed (clinically and by EEG) as having temporal lobe epilepsy aged 8 to 14 years (mean, 10.4 years) and 20 healthy children with comparable age and gender as the control group. All patients were subjected to clinical examination, interictal electroencephalography and magnetic resonance imaging (MRI). Proton magnetic resonance spectroscopic examination (MRS) was performed to the patients and the controls.
  
  
  RESULTS
  According to the findings of electroencephalography, our patients were classified to three groups: Group 1 included 20 patients with unitemporal (lateralized) epileptic focus, group 2 included 12 patients with bitemporal (non-lateralized) epileptic focus and group 3 included 8 patients with normal electroencephalography. Magnetic resonance spectroscopy could lateralize the epileptic focus in 19 patients in group 1, nine patients in group2 and five patients in group 3 with overall lateralization of (82.5%), while electroencephalography was able to lateralize the focus in (50%) of patients and magnetic resonance imaging detected lateralization of mesial temporal sclerosis in (57.5%) of patients.
  
  
  CONCLUSIONS
  Magnetic resonance spectroscopy is a promising tool in evaluating patients with epilepsy and offers increased sensitivity to detect temporal pathology that is not obvious on structural MRI imaging.
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. Seham_Azab@yahoo.com.
authors.forename: Seham Fa
authors.initials: SF
authors.lastname: Azab
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. lamesh25@yahoo.com.
authors.forename: Laila M
authors.initials: LM
authors.lastname: Sherief
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. safaahamdy11@yahoo.com.
authors.forename: Safaa H
authors.initials: SH
authors.lastname: Saleh
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. mona1234455@hotmail.com.
authors.forename: Mona M
authors.initials: MM
authors.lastname: Elshafeiy
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. agsiam@hotmail.com.
authors.forename: Ahmed G
authors.initials: AG
authors.lastname: Siam
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. dr.wafaaelsaeed@live.com.
authors.forename: Wafaa F
authors.initials: WF
authors.lastname: Elsaeed
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. Moharafaped@gmail.com.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Arafa
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. em_ben2010@yahoo.com.
authors.forename: Eman A
authors.initials: EA
authors.lastname: Bendary
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. h_sherbiny@zu.edu.eg.
authors.forename: Hanan S
authors.initials: HS
authors.lastname: Sherbiny
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. elbehedyr@yahoo.com.
authors.forename: Rabab M
authors.initials: RM
authors.lastname: Elbehedy
authors.affiliation: Faculty of Medicine, Zagazig University, 18 Omar Bin Elkhattab St, Al Qawmia, Zagazig City, Sharkia Governorate, Egypt. sonoscan9001@yahoo.com.
authors.forename: Khalid A
authors.initials: KA
authors.lastname: Aziz
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male