title: Changes of TIZ expression in epithelial ovarian cancer cells.
abstract: OBJECTIVE
  To study the change of TIZ expression in epithelial ovarian cancer cells.
  
  
  METHODS
  HO8910 cells were transinfected with siRNA to inhibit the expression of TIZ. pcDNA3.1-TIZ vectors were combined to increase the TIZ expression level. The cell viability, colony forming efficiency and cycle distribution of HO8910, HO8910/NC, HO8910/pcDNA3.1-NC, HO8910/TIZ-573 and H08910/pcDNA3.1-TIZ were compared, and the invasion rate, migration rate and adhesion rate between 5 groups of cells were compared.
  
  
  RESULTS
  Compared with those of HO8910, HO8910/NC and HO8910/pcDNA3.1-NC, the cell viability, colony forming efficiency and cell cycle distribution of HO8910/TIZ-573 were increased, while the indexes of H08910/pcDNA3.1-NC were decreased with statistical significant difference (P<0.05). There was no statistical significant difference in the invasion rate, migration rate and adhesion rate between 5 groups of cells (P>0.05).
  
  
  CONCLUSIONS
  The expression of TIZ can inhibit the proliferation of epithelial ovarian cancer cells.
authors.affiliation: Department of Obstetrics & Gynecology, Affiliated Tangshan Workers Hospital of Hebei Medical University, Tangshan, Hebei 063000, China.
authors.forename: Huan-Yu
authors.initials: HY
authors.lastname: Zheng
authors.affiliation: Department of Pharmacy, Tangshan People's Hospital, Tangshan, Hebei 063000, China.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Zheng
authors.affiliation: Central Laboratory, Affiliated Tangshan Workers Hospital of Hebei Medical University, Tangshan, Hebei 063000, China.
authors.forename: Yun-Tao
authors.initials: YT
authors.lastname: Zhou
authors.affiliation: Department of Obstetrics & Gynecology, Affiliated Tangshan Workers Hospital of Hebei Medical University, Tangshan, Hebei 063000, China. Electronic address: luienlin669@126.com.
authors.forename: En-Ling
authors.initials: EL
authors.lastname: Liu
authors.affiliation: Department of Obstetrics & Gynecology, Affiliated Tangshan Workers Hospital of Hebei Medical University, Tangshan, Hebei 063000, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Obstetrics & Gynecology, Affiliated Tangshan Workers Hospital of Hebei Medical University, Tangshan, Hebei 063000, China.
authors.forename: Yan-Mei
authors.initials: YM
authors.lastname: Zhang
keywords: Cell proliferation; Epithelial ovarian cancer cells; Invasion ability; TIZ expression