title: Q-r curve of thermal tomography and its clinical application on breast tumor diagnosis.
abstract: Heat is the product following the metabolism of cells, and the metabolism is closely related with the pathological information of living organism. So, there are strong ties between the heat distribution and the pathological state in living organism. In this paper, the mathematical function δ is introduced in the classical Pennes bio-heat transfer equation as the point heat source. By simplifying the boundary conditions, a novel bio-heat transfer model is established and solved in a spherical coordinate system. Based on the temperature distribution of human body surface, the information of heat source is mined layer by layer, and the corresponding q-r curve of heat intensity varying with depth is acquired combining the fitting method of Lorentz curve. According to a large number of clinical confirmed cases and statistics, the diagnostic criteria judging diseases by q-r curve are proposed. Five typical clinical practices are performed and four of the diagnosis results are very consistent with those of molybdenum target (MT) X-ray, B-ultrasonic images and pathological examination, one gives the result of early stage malignant tumor that MT X-ray and B-ultrasonic can't check out. It is a radiation-free green method with noninvasive diagnostic procedure and accurate diagnosis result.
authors.affiliation: Department of Electronic Science and Technology, School of Physics and Technology, Wuhan University, Wuhan 430072, China ; School of Biomedical Engineering, Hubei University of Science and Technology, Xianning 437100, China.
authors.forename: Guilian
authors.initials: G
authors.lastname: Shi
authors.affiliation: Department of Electronic Science and Technology, School of Physics and Technology, Wuhan University, Wuhan 430072, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Han
authors.affiliation: Department of Electronic Science and Technology, School of Physics and Technology, Wuhan University, Wuhan 430072, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Electronic Science and Technology, School of Physics and Technology, Wuhan University, Wuhan 430072, China.
authors.forename: Chengwen
authors.initials: C
authors.lastname: Liang
authors.affiliation: Department of Electronic Science and Technology, School of Physics and Technology, Wuhan University, Wuhan 430072, China.
authors.forename: Kaiyang
authors.initials: K
authors.lastname: Li
keywords: (170.3660) Light propagation in tissues; (170.4580) Optical diagnostics for medicine; (170.6510) Spectroscopy, tissue diagnostics