title: Validation of the Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition Recommendations for Caloric Provision to Critically Ill Obese Patients: A Pilot Study.
abstract: The Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (ASPEN) recommend that obese, critically ill patients receive 11-14 kcal/kg/d using actual body weight (ABW) or 22-25 kcal/kg/d using ideal body weight (IBW), because feeding these patients 50%-70% maintenance needs while administering high protein may improve outcomes. It is unknown whether these equations achieve this target when validated against indirect calorimetry, perform equally across all degrees of obesity, or compare well with other equations.
  
  
  
  Measured resting energy expenditure (MREE) was determined in obese (body mass index [BMI] ≥30 kg/m(2)), critically ill patients. Resting energy expenditure was predicted (PREE) using several equations: 12.5 kcal/kg ABW (ASPEN-Actual BW), 23.5 kcal/kg IBW (ASPEN-Ideal BW), Harris-Benedict (adjusted-weight and 1.5 stress-factor), and Ireton-Jones for obesity. Correlation of PREE to 65% MREE, predictive accuracy, precision, bias, and large error incidence were calculated.
  
  
  
  All equations were significantly correlated with 65% MREE but had poor predictive accuracy, had excessive large error incidence, were imprecise, and were biased in the entire cohort (N = 31). In the obesity cohort (n = 20, BMI 30-50 kg/m(2)), ASPEN-Actual BW had acceptable predictive accuracy and large error incidence, was unbiased, and was nearly precise. In super obesity (n = 11, BMI >50 kg/m(2)), ASPEN-Ideal BW had acceptable predictive accuracy and large error incidence and was precise and unbiased.
  
  
  
  SCCM/ASPEN-recommended body weight equations are reasonable predictors of 65% MREE depending on the equation and degree of obesity. Assuming that feeding 65% MREE is appropriate, this study suggests that patients with a BMI 30-50 kg/m(2) should receive 11-14 kcal/kg/d using ABW and those with a BMI >50 kg/m(2) should receive 22-25 kcal/kg/d using IBW.
authors.affiliation: Department of Nutrition, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Kris M
authors.initials: KM
authors.lastname: Mogensen
authors.affiliation: Department of Nutrition, Brigham and Women's Hospital, Boston, Massachusetts Duke University School of Medicine, Durham, North Carolina.
authors.forename: Benjamin Y
authors.initials: BY
authors.lastname: Andrew
authors.affiliation: Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Jasmine C
authors.initials: JC
authors.lastname: Corona
authors.affiliation: Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts Department of Surgery, Harvard Medical School, Boston, Massachusetts mkrobinson@partners.org.
authors.forename: Malcolm K
authors.initials: MK
authors.lastname: Robinson
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002153:Calorimetry, Indirect; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy; D002149:Energy Intake; D004734:Energy Metabolism; D004750:Enteral Nutrition / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009751:Nutritional Requirements; D009765:Obesity / Q000628:therapy*; D010288:Parenteral Nutrition / Q000379:methods*; D011237:Predictive Value of Tests; D064167:Recommended Dietary Allowances; D012146:Rest; D012680:Sensitivity and Specificity; D012955:Societies, Medical; D014481:United States
keywords: critical care; energy expenditure; indirect calorimetry; obesity; predictive equations; underfeeding