title: Features of the Structure of the Circadian Rhythm of Blood Pressure and Heart Rate under Genetically Determined Hypertension in the Experiment.
abstract: In SHR rats of different ages (22, 26, 30, 34, and 38 weeks), continuous 24-h telemetric monitoring of BP and HR was performed. The amplitude and power of oscillations of diastolic BP significantly decreased at the later stages of arterial hypertension (38 weeks), which was considered as a poor prognostic marker. We also observed a significant decrease in the mean daytime, nighttime, and maximum HR and mesor on weeks 30 and 34, but not on week 38, which can reflect triggering of the adaptive response followed by its exhaustion.
authors.affiliation: Department of General Pathology and Pathophysiology, Medical Faculty, People's Friendship University of Russia, Moscow, Russia, blagonravovm@mail.ru.
authors.forename: M L
authors.initials: ML
authors.lastname: Blagonravov
authors.forename: V A
authors.initials: VA
authors.lastname: Frolov
authors.forename: V A
authors.initials: VA
authors.lastname: Goryachev
authors.forename: M M
authors.initials: MM
authors.lastname: Azova
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar