title: Synthesis, characterization, and tyrosinase inhibitory properties of benzimidazole derivatives.
abstract: 1-Alkylbenzimidazole and 1,3-dialkyl benzimidazolium salts were synthesized and characterized by the data of IR, 1H NMR, 13C NMR spectra and elemental analyses. These compounds were investigated as tyrosinase inhibitors. Tyrosinase has been purified from banana by affinity chromatography on a Sepharose 4B gel conjugated with L-tyrosine-p-aminobenzoic acid. All the synthesized compounds inhibited the tyrosinase activity. Among the compounds studied, 1,4-di(1H-benzo[d]imidazol-1-yl)butane was found to be the most active tyrosinase inhibitor (IC50 0.31 mM).
authors.forename: Mert Olgun
authors.initials: MO
authors.lastname: Karatas
authors.forename: Bulent
authors.initials: B
authors.lastname: Alici
authors.forename: Engin
authors.initials: E
authors.lastname: Cetinkaya
authors.forename: Ciğdem
authors.initials: C
authors.lastname: Bilen
authors.forename: Nahit
authors.initials: N
authors.lastname: Gençer
authors.forename: Oktay
authors.initials: O
authors.lastname: Arslan
mesh_terms: D010129:4-Aminobenzoic Acid; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014443:Tyrosine / Q000737:chemistry / Q000378:metabolism
chemical_list: D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D014443:Tyrosine; C031000:benzimidazole; D014442:Monophenol Monooxygenase; D010129:4-Aminobenzoic Acid