title: Insights into protein interaction networks reveal non-receptor kinases as significant druggable targets for psoriasis.
abstract: Psoriasis is a chronic disease of the skin characterized by hyper proliferation and inflammation of the epidermis and dermal components of the skin. T-cell-dependent inflammatory process in skin governs the pathogenesis of psoriasis. An in-silico search strategy was utilized to identify psoriatic therapeutic drug targets. The gene expression profiling of psoriatic skin identified a total of 427 differentially expressed genes (DEGs). Gene ontology investigation of DEGs identified genes involved in calcium binding, apoptosis, keratinisation, lipid transportation and homeostasis apart from immune mediated processes. The protein interaction networks identified proteins involved in various signaling mechanisms with high degree of interconnections. The gene modules derived from the main network were enriched with rich kinome. These sub-networks were dominated by the presence of non-receptor kinase family members which are major signal transmitters in immune response. The computational approach has aided in the identification of non-receptor kinases as potential targets for psoriasis drug development.
authors.affiliation: Bioinformatics Division, School of Biosciences and Technology, Vellore Institute of Technology University, India.
authors.forename: Sudharsana
authors.initials: S
authors.lastname: Sundarrajan
authors.affiliation: Bioinformatics Division, School of Biosciences and Technology, Vellore Institute of Technology University, India.
authors.forename: Sajitha
authors.initials: S
authors.lastname: Lulu
authors.affiliation: Bioinformatics Division, School of Biosciences and Technology, Vellore Institute of Technology University, India. Electronic address: mohanapriyaa@vit.ac.in.
authors.forename: Mohanapriya
authors.initials: M
authors.lastname: Arumugam
mesh_terms: D006801:Humans; D060066:Protein Interaction Maps; D011494:Protein Kinases / Q000187:drug effects* / Q000378:metabolism; D011565:Psoriasis / Q000188:drug therapy* / Q000201:enzymology
chemical_list: D011494:Protein Kinases
keywords: Gene expression profiling; Gene modules; Gene ontology; Protein interaction network; Psoriasis