title: Double- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade.
abstract: Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative nosocomial pathogens commonly carry one carbapenemase gene conferring resistance to carbapenems and other beta-lactam antibiotics. However, increasing reports show that double-carbapenemase-producing (DCP) and even multi-carbapenemase-producing (MCP) bacteria are emerging in some parts of the world, diminishing further, in some cases, the already limited treatment options. In the present review, the up-to-date reports of DCP and MCP isolates are summarized and concerns regarding their emergence are discussed.
authors.affiliation: Labnet Laboratories, Agiou Dimitriou str. 161, 53337, Thessaloniki, Greece, meletisg@hotmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Meletis
authors.forename: D
authors.initials: D
authors.lastname: Chatzidimitriou
authors.forename: N
authors.initials: N
authors.lastname: Malisiovas
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D024901:Drug Resistance, Multiple, Bacterial; D014943:Global Health; D006090:Gram-Negative Bacteria / Q000201:enzymology* / Q000235:genetics; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase