title: Consensus document on the approach to children with allergic reactions after vaccination or allergy to vaccine components.
abstract: Vaccinations are one of the main public health tools for the control of vaccine-preventable diseases. If a child is identified as having had an allergic reaction to a vaccine, subsequent immunisations will probably be suspended - with the risks such a decision implies. The incidence of severe allergic reactions is very low, ranging between 0.5 and 1 cases/100,000 doses. Rather than the vaccine antigens as such, the causes of allergic reactions to vaccines are often residual protein components of the manufacturing process such as gelatine or egg, and less commonly yeasts or latex. Most vaccine reactions are mild and circumscribed to the injection site; although in some cases severe anaphylactic reactions can be observed. If an immediate-type allergic reaction is suspected at vaccination, or if a child with allergy to some of the vaccine components is scheduled for vaccination, a correct diagnosis of the possible allergic process must be made. The usual vaccine components must be known in order to determine whether vaccination can be safely performed.
authors.affiliation: Unidad de Alergia y Neumología Pediátrica, Servicio de Pediatría, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain. Electronic address: lecheverria3@gmail.com.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Echeverría-Zudaire
authors.affiliation: Servicio de Pediatría, Hospital Universitario Ntra. Sra. de Candelaria (HUNSC), Santa Cruz de Tenerife, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Ortigosa-del Castillo
authors.affiliation: Servicio de Alergia, Hospital Materno-Infantil Gregorio Marañón, Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Alonso-Lebrero
authors.affiliation: Centro de Salud de Llanera, Llanera, Asturias, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Álvarez-García
authors.affiliation: Unidad de Alergia Infantil, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Cortés-Álvarez
authors.affiliation: Centro de Salud "Delicias Sur", Zaragoza, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: García-Sánchez
authors.affiliation: Unidad de Alergología, Hospital General Universitario, Valencia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Martorell-Aragonés
mesh_terms: D002648:Child; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis*; D006969:Hypersensitivity, Immediate / Q000175:diagnosis*; D007073:Immunoglobulin E / Q000097:blood; D013030:Spain; D014611:Vaccination; D014612:Vaccines / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014612:Vaccines; D007073:Immunoglobulin E
keywords: Anaphylaxis; Child; Delayed reactions; Gelatin; Immunization; Vaccination; Vaccines; Vaccines allergy