title: Transition-Metal-Free C-3 Arylation of Quinoline-4-ones with Arylhydrazines.
abstract: A transition-metal-free C-3-arylation of quinolin-4-ones in the presence of base has been achieved by using arylhydrazines as aryl radical source and air as oxidant. The reaction proceeds smoothly at room temperature and does not require any prefunctionalization and N-protection of quinoline-4-ones. The utility of this methodology is further demonstrated in synthesis of quinoline-quinolone hybrid as well as 6-aryl-benzofuro[3,2-c]quinoline scaffold.
authors.affiliation: †Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Makthala
authors.initials: M
authors.lastname: Ravi
authors.affiliation: †Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Parul
authors.initials: P
authors.lastname: Chauhan
authors.affiliation: ‡Division of Molecular and Structural Biology, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Ruchir
authors.initials: R
authors.lastname: Kant
authors.affiliation: ∥Sophisticated Analytical Instrument Facility, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Sanjeev K
authors.initials: SK
authors.lastname: Shukla
authors.affiliation: †Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India.
authors.forename: Prem P
authors.initials: PP
authors.lastname: Yadav
mesh_terms: D002384:Catalysis; D006834:Hydrazines / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D006834:Hydrazines; D008670:Metals; D015363:Quinolones; D028561:Transition Elements