title: Predicting 5- and 10-year survival in older women with early-stage breast cancer: self-rated health and walking ability.
abstract: OBJECTIVE
  To determine life expectancy for older women with breast cancer.
  
  
  METHODS
  Prospective longitudinal study with 10 years of follow-up data.
  
  
  METHODS
  Hospitals or collaborating tumor registries in four geographic regions (Los Angeles, California; Minnesota; North Carolina; Rhode Island).
  
  
  METHODS
  Women aged 65 and older at time of breast cancer diagnosis with Stage I to IIIA disease with measures of self-rated health (SRH) and walking ability at baseline (N = 615; 17% aged ≥80, 52% Stage I, 58% with ≥2 comorbidities).
  
  
  METHODS
  Baseline SRH, baseline self-reported walking ability, all-cause and breast cancer-specific estimated probability of 5- and 10-year survival.
  
  
  RESULTS
  At the time of breast cancer diagnosis, 39% of women reported poor SRH, and 28% reported limited ability to walk several blocks. The all-cause survival curves appear to separate after approximately 3 years, and the difference in survival probability between those with low SRH and limited walking ability and those with high SRH and no walking ability limitation was significant (0.708 vs 0.855 at 5 years, P ≤ .001; 0.300 vs 0.648 at 10 years, P < .001). There were no differences between the groups in breast cancer-specific survival at 5 and 10 years (P = .66 at 5 years, P = .16 at 10 years).
  
  
  CONCLUSIONS
  The combination of low SRH and limited ability to walk several blocks at diagnosis is an important predictor of worse all-cause survival at 5 and 10 years. These self-report measures easily assessed in clinical practice may be an effective strategy to improve treatment decision-making in older adults with cancer.
authors.affiliation: Division of Geriatrics, University of California at San Francisco, San Francisco, California; San Francisco Veterans Affairs Medical Center, San Francisco, California.
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Eng
authors.forename: Kerri
authors.initials: K
authors.lastname: Clough-Gorr
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Cabral
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Silliman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality*; D005260:Female; D005544:Forecasting; D006304:Health Status; D006801:Humans; D008137:Longitudinal Studies; D015141:Los Angeles / Q000453:epidemiology; D008910:Minnesota / Q000453:epidemiology; D009367:Neoplasm Staging; D009657:North Carolina / Q000453:epidemiology; D011336:Probability; D011446:Prospective Studies; D012042:Registries; D012237:Rhode Island / Q000453:epidemiology; D016138:Walking
keywords: breast cancer; physical function; self-rated health