title: Inferior peduncle lesion presenting with bilaterally impaired vestibular responses to horizontal and posterior head impulses.
abstract: Differentiating central from peripheral origins of vestibulo-ocular reflex (VOR) lesions can be challenging. A 36-year old man presented with a 1-year history of progressive unsteadiness. The video-Head Impulse Test revealed a significantly reduced VOR gain in both horizontal and posterior canals (0.49 ± 0.05 and 0.38 ± 0.06) but normal VOR responses in both anterior canals (0.89 ± 0.08 and 1.04 ± 0.15). No plausible combination of end-organ lesion should be responsible for these observations. A brain magnetic resonance imaging disclosed a left inferior cerebellar peduncle lesion suggestive of a glioma.
authors.affiliation: Clínica Maia, Canoas-RS.
authors.forename: Francisco
authors.initials: F
authors.lastname: Zuma e Maia
authors.affiliation: Health Sciences Institute, Portuguese Catholic University.|Translational Clinical Physiology Unit, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon.|Department of Otolaryngology, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.
authors.forename: Leonel
authors.initials: L
authors.lastname: Luis
mesh_terms: D000328:Adult; D002528:Cerebellar Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D005910:Glioma / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*
keywords: cerebellar lesion; vestibular; vestibulo-ocular reflex (VOR)