title: Intravenous Acetaminophen in Orbital Surgery.
abstract: OBJECTIVE
  To assess the role of intravenous acetaminophen (IVA) in orbital surgery.
  
  
  METHODS
  Fifty control patients underwent orbital surgery without IVA. Fifty patients received 1 g of IVA within 30 minutes of surgery, and 50 patients received 1 g of IVA immediately preoperatively. Postoperative requirements for analgesic and anti-emetic medications and standardized pain scores were recorded.
  
  
  RESULTS
  44 patients (88%) in the control group and 57 patients (57%) that received IVA preoperatively required analgesic medications (p = 0.0023). 31 patients (62%) that received the medication within 30 minutes of surgery and 26 patients (52%) that received IVA immediately preoperatively required analgesic medications (p = 0.77). The control group had a greater requirement for analgesic medications than patients that received IVA within 30 minutes of orbital surgery (p = 0.0076) and those that received IVA immediately preoperatively (p = 0.032). Twelve patients in the control group (24%) and 4 patients (4%) in the group that received IVA preoperatively received anti-emetic medications (p = 0.0078). Mean pain scores for all patients that received IVA, patients that received IVA within 30 minutes of surgery, and patients that received IVA at the time of surgery were 3.68 (standard deviation = 3.24), 3.12 (standard deviation = 3.05) and 4.39 (standard deviation = 3.37), respectively, as compared to a mean control group score of 7.92 (standard deviation = 3.36), (p = 8.30x10).
  
  
  CONCLUSIONS
  When administered prior to orbital surgery, IVA significantly reduced pain scores and postoperative requirements for analgesic and anti-nausea medications.
authors.affiliation: *Ophthalmic Plastic Surgery, Lions Eye Institute, Department of Ophthalmology, and †Department of Anesthesiology, Albany Medical College, Albany, New York, U.S.A.
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Wladis
authors.forename: Dino F
authors.initials: DF
authors.lastname: Kattato
authors.forename: Arup
authors.initials: A
authors.lastname: De
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D009916:Orbital Diseases / Q000601:surgery*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy*; D011182:Postoperative Care / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen