title: Maternal and fetal outcomes in pregnant women with acute promyelocytic leukemia.
abstract: The management of pregnant women with acute promyelocytic leukemia (APL) is a challenge with limited evidence-based information available. We are reporting a series of 14 consecutive pregnant women with APL who were registered in the PETHEMA Data Centre between 1996 and 2012. APL was diagnosed during early pregnancy in five women, late pregnancy in seven, and two additional patients after delivery in an extremely poor clinical condition (pulmonary and cerebral hemorrhage). Eleven of the 12 patients eligible for induction therapy with all-trans retinoic acid and idarubicin achieved complete remission (CR 92 %) and are still in the first CR. All early pregnancies ended in abortion (four induced and one spontaneous), with four of them achieving CR. Eight of nine women in late pregnancy delivered a healthy infant (six cesarean section and two vaginal delivery). All eight babies developed normally. Our results confirm a high cure rate for pregnant women with APL who received all-trans retinoic acid and idarubicin for induction therapy, and an excellent outcome for babies when the disease is diagnosed during late pregnancy.
authors.affiliation: Department of Haematology, University Hospital La Fe, Avinguda Fernando Abril Martorell, 106, 46026, Valencia, Spain, msanz@uv.es.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sanz
authors.forename: Pau
authors.initials: P
authors.lastname: Montesinos
authors.forename: María F
authors.initials: MF
authors.lastname: Casale
authors.forename: Joaquín
authors.initials: J
authors.lastname: Díaz-Mediavilla
authors.forename: Santiago
authors.initials: S
authors.lastname: Jiménez
authors.forename: Isolda
authors.initials: I
authors.lastname: Fernández
authors.forename: Pascual
authors.initials: P
authors.lastname: Fernández
authors.forename: José
authors.initials: J
authors.lastname: González-Campos
authors.forename: José D
authors.initials: JD
authors.lastname: González
authors.forename: Pilar
authors.initials: P
authors.lastname: Herrera
authors.forename: Elena
authors.initials: E
authors.lastname: de Lisa
authors.forename: Teresa
authors.initials: T
authors.lastname: Olave
authors.forename: Rafael
authors.initials: R
authors.lastname: Rojas
authors.forename: Olga
authors.initials: O
authors.lastname: Salamero
authors.forename: María J
authors.initials: MJ
authors.lastname: Sayas
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellicer
authors.forename: Alfredo
authors.initials: A
authors.lastname: Perales
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016208:Databases, Factual / Q000639:trends; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis* / Q000188:drug therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000188:drug therapy*; D011256:Pregnancy Outcome; D012074:Remission Induction / Q000379:methods; D014212:Tretinoin / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D014212:Tretinoin; D015255:Idarubicin