title: Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer.
abstract: BACKGROUND
  Aberrant expression of serine threonine tyrosine kinase 1 (STYK1) has been reported in several human malignancies including colorectal cancer (CRC). However, the prognostic significance of STYK1 expression in CRC remains unknown.
  
  
  METHODS
  STYK1 protein expression in paraffin-embedded CRC specimens was determined immunohistochemically. The correlation of STYK1 expression with clinicopathologic features was assessed in a cohort containing 353 patients with primary CRC. Kaplan-Meier and Cox proportional regression analyses were used to evaluate the association between STYK1 expression and patients' survival.
  
  
  RESULTS
  STYK1 expression was frequently up-regulated in CRC clinical samples at the protein levels and was significantly associated with tumor differentiation grade (p = 0.030), lymph node metastasis (p = 0.004), TNM stage (p = 0.007) and patient death (p < 0.001). Kaplan-Meier analysis indicated that patients with high intratumoral STYK1 expression had a significantly shorter disease-specific survival (DSS) than those with low expression (p < 0.001). Importantly, high levels of STYK1 protein predicted poor DSS for both stage II (p < 0.001) and stage III (p = 0.004) patients. Furthermore, multivariate analyses revealed that STYK1 protein expression was an independent prognostic indicator for both stage II (hazard ratio [HR], 2.472; p = 0.001) and stage III (HR, 2.001; p = 0.004) patients.
  
  
  CONCLUSIONS
  Our results suggest that increased STYK1 protein expression correlates with disease progression and metastasis and may serve as a predictor of poor survival in CRC.
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China. lianghudoc@163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Oncology, 150th Hospital of PLA, Luoyang, China. chenocean@163.com.
authors.forename: Hai-Yang
authors.initials: HY
authors.lastname: Chen
authors.affiliation: Department of Colorectal Surgery, 150th Hospital of PLA, Luoyang, China. jiancai150@yeah.net.
authors.forename: Jian
authors.initials: J
authors.lastname: Cai
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China. yuzhang150@126.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China. chenye_qi@163.com.
authors.forename: Chen-Ye
authors.initials: CY
authors.lastname: Qi
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China. hui_gong@yeah.net.
authors.forename: Hui
authors.initials: H
authors.lastname: Gong
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China. yanxiazai@163.com.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Zhai
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China. fuhao_150@163.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Fu
authors.affiliation: Department of Clinical Laboratory, 150th Hospital of PLA, Luoyang, China. guangzyang@163.com.
authors.forename: Guang-Zhen
authors.initials: GZ
authors.lastname: Yang
authors.affiliation: Anal-Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China. chunfgao@163.com.
authors.forename: Chun-Fang
authors.initials: CF
authors.lastname: Gao
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000401:mortality*; D018450:Disease Progression; D005260:Female; D015870:Gene Expression; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; D020794:Receptor Protein-Tyrosine Kinases; C482299:STYK1 protein, human