title: To evaluate the damage of renal function in CIAKI rats at 3T: using ASL and BOLD MRI.
abstract: OBJECTIVE
  To investigate noninvasive arterial spin-labeling (ASL) and blood oxygen level-dependent imaging (BOLD) sequences for measuring renal hemodynamics and oxygenation in contrast induced acute kidney injury (CIAKI) rat.
  
  
  METHODS
  Thirteen SD rats were randomly grouped into CIAKI group and control group. Both ASL and BOLD sequences were performed at 24 h preinjection and at intervals of 0.5, 12, 24, 48, 72, and 96 h postinjection to assess renal blood flow (RBF) and relative spin-spin relaxation rate (R2(*)), respectively.
  
  
  RESULTS
  For the CIAKI group, the value of RBF in the cortex (CO) and outer medulla (OM) of the kidney was significantly decreased (P < 0.05) at 12-48 h and regressed to baseline level (P = NS) at 72-96 h. In OM, the value of R2(*) was increased at 0.5-48 h (P < 0.05) and not statistically significant (P = NS) at 72 and 96 h.
  
  
  CONCLUSIONS
  RBF in OM and CO and oxygen level in OM were decreased postinjection of CM. ASL combining BOLD can further identify the primary cause of the decrease of renal oxygenation in CIAKI. This approach provides means for noninvasive monitoring renal function during the first 4 days of CIAKI in clinical routine work.
authors.affiliation: Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China ; Department of Radiology, HuiZhou Municipal Central Hospital, No. 41 E Ling Bei Road, Huizhou, Guangdong Province 516008, China.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Chen
authors.affiliation: Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China ; Southern Medical University, No. 1838 Dadao Bei Road, Guangzhou, Guangdong Province 510515, China.
authors.forename: Long
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China ; Southern Medical University, No. 1838 Dadao Bei Road, Guangzhou, Guangdong Province 510515, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China.
authors.forename: Chun-Ling
authors.initials: CL
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China.
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Luo
authors.affiliation: Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China.
authors.forename: Qiong-Xin
authors.initials: QX
authors.lastname: Zeng
authors.affiliation: Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China.
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Liang
authors.affiliation: F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA ; The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Guan-Shu
authors.initials: GS
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, No. 106 Zhongshan Er Road, Guangzhou, Guangdong Province 510080, China ; Southern Medical University, No. 1838 Dadao Bei Road, Guangzhou, Guangdong Province 510515, China.
authors.forename: Shui-Xing
authors.initials: SX
authors.lastname: Zhang
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D000818:Animals; D007672:Kidney Cortex / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D011859:Radiography; D051381:Rats; D017207:Rats, Sprague-Dawley; D013113:Spin Labels
chemical_list: D013113:Spin Labels; D010100:Oxygen