title: Antenatal magnesium sulfate and neurodevelopmental outcome of preterm infants born to preeclamptic mothers.
abstract: OBJECTIVE
  Previous studies demonstrated that magnesium sulfate is associated with better neurological outcome and decreased cerebral palsy rates in preterm newborns. The aim of this study is to assess the effects of antenatal magnesium sulfate on neurodevelopmental outcomes of preterm infants.
  
  
  METHODS
  Preterm newborns with a gestational age of <32 weeks whose mothers were diagnosed with preeclampsia were extracted from the hospital records and files retrospectively. The neurodevelopmental assessment was performed at 2 years of age by developmental pediatrician. The results of the infants exposed to antenatal magnesium sulfate were compared with the control group.
  
  
  RESULTS
  Between the years 2010 and 2012, 387 preterm babies were born to preeclamptic mothers. Fifty-nine (15.2%) of them were exposed to antenatal magnesium sulfate. The main clinical characteristics did not differ between the groups. On the other hand, cerebral palsy was significantly lower in preterm infants exposed to magnesium sulfate compared to the control group (3.3% and 12.2%, respectively, p = 0.004). On multinominal logistic regression analysis, magnesium sulfate was not an independent significant factor to reduce CP on its own.
  
  
  CONCLUSIONS
  Antenatal magnesium sulfate can be used as a neuroprotective strategy especially for the prevention of cerebral palsy in preterm infants. Future studies should be designed to support the positive effect of antenatal magnesium sulfate on neurologic development.
authors.affiliation: a Department of Neonatology and.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Bozkurt
authors.affiliation: b Department of Developmental Behavioral Pediatrics , Zekai Tahir Burak Maternity Teahing Hospital , Ankara , Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Eras
authors.affiliation: a Department of Neonatology and.
authors.forename: Fuat Emre
authors.initials: FE
authors.lastname: Canpolat
authors.affiliation: a Department of Neonatology and.
authors.forename: Serife Suna
authors.initials: SS
authors.lastname: Oguz
authors.affiliation: a Department of Neonatology and.
authors.forename: Nurdan
authors.initials: N
authors.lastname: Uras
authors.affiliation: a Department of Neonatology and.
authors.forename: Ugur
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D000328:Adult; D001921:Brain / Q000187:drug effects* / Q000254:growth & development*; D002657:Child Development / Q000187:drug effects; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development / Q000523:psychology; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008297:Male; D011225:Pre-Eclampsia / Q000188:drug therapy* / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D047928:Premature Birth / Q000453:epidemiology; D011295:Prenatal Care / Q000379:methods; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000523:psychology; D012189:Retrospective Studies
chemical_list: D008278:Magnesium Sulfate
keywords: Antenatal; magnesium sulfate; neurodevelopment; preeclampsia; preterm