title: Our own worst enemy: pharmacologic mechanisms of hypertension.
abstract: Drug-induced hypertension is often an unrecognized cause of resistant or secondary hypertension. It is defined as hypertension resulting from the unintended effect of a drug or from a drug's antagonistic effect on antihypertensive medications. The main mechanisms of drug-induced hypertension, when categorized broadly, include volume retention and sympathomimetic effects. These mechanisms along with management strategies will be further discussed in this article.
authors.affiliation: School of Pharmacy, University of Missouri-Kansas City and Department of Pharmacy, University of Missouri Health Care, Columbia, MO; School of Pharmacy, University of Missouri-Kansas City and Department of Pharmacy, Harry S. Truman VA, Columbia, MO.
authors.forename: Lynn E
authors.initials: LE
authors.lastname: Kassel
authors.affiliation: School of Pharmacy, University of Missouri-Kansas City and Department of Pharmacy, University of Missouri Health Care, Columbia, MO; School of Pharmacy, University of Missouri-Kansas City and Department of Pharmacy, Harry S. Truman VA, Columbia, MO. Electronic address: oduml@umkc.edu.
authors.forename: Lauren E
authors.initials: LE
authors.lastname: Odum
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D065095:Calcineurin Inhibitors / Q000009:adverse effects*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D006397:Hematinics / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D020533:Angiogenesis Inhibitors; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D065095:Calcineurin Inhibitors; D003278:Contraceptives, Oral, Hormonal; D006397:Hematinics
keywords: Blood pressure; Drug induced; Hypertension; Resistant hypertension; Secondary hypertension