title: [Analysis of vertebrobasilar dolichoectasia based on computational fluid dynamics].
abstract: OBJECTIVE
  To analyze the hemodynamic states of vertebrobasilar dolichoectasia based on computational fluid dynamics technique.
  
  
  METHODS
  The original DICOM format image data from a patient with vertebrobasilar dolichoectasia (VBD), were imported by the Mimics software directly,and the 3D Objects were constructed.The simulation of model was made with Ansys software, the hemodynamic parameters such as streamlines, wall shear stress (WSS) and wall pressure were described.
  
  
  RESULTS
  There was stable laminar flow in proximal basilar artery and was no blood flow mixed by bilateral vertebral artery.However, Spiral flows were appeared in distal tortuous basilar artery. The low WSS regions in the vertebrabasilar junction section and inferior segment of basilar artery were coincide with the high wall pressure regions.It could be speculated the initial growth regions might be located in the vertebrabasilar junction section and inferior segment of basilar artery.Local regions with low WSS and high wall pressure might be associated with the occurrence and development of VBD.
  
  
  CONCLUSIONS
  CFD numerical simulation maybe can provide a theoretical basis for the role of hemodynamic factors in occurrence and development of VBD.
authors.affiliation: Interventional Radiology and Vascular Surgery Department, Peking University Third Hospital, Beijing 100191, China.
authors.forename: J T
authors.initials: JT
authors.lastname: Han
authors.affiliation: Biological and Medical Engineering, Beijing University of Aeronautics and Astronautics,Beijing 100191, China.
authors.forename: H T
authors.initials: HT
authors.lastname: Qiao
authors.affiliation: China Nuclear Power Engineering Co.Ltd,Beijing 100840, China.
authors.forename: X
authors.initials: X
authors.lastname: Han
authors.affiliation: Interventional Radiology and Vascular Surgery Department, Peking University Third Hospital, Beijing 100191, China.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Radiology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: He
authors.affiliation: Department of Neurology,Peking University Third Hospital, Beijing 100191, China.
authors.forename: S
authors.initials: S
authors.lastname: Ye
authors.affiliation: Interventional Radiology and Vascular Surgery Department, Peking University Third Hospital, Beijing 100191, China.
authors.forename: J Y
authors.initials: JY
authors.lastname: Luan
authors.affiliation: Interventional Radiology and Vascular Surgery Department, Peking University Third Hospital, Beijing 100191, China.
authors.forename: C M
authors.initials: CM
authors.lastname: Wang
authors.affiliation: Interventional Radiology and Vascular Surgery Department, Peking University Third Hospital, Beijing 100191, China.
authors.forename: G X
authors.initials: GX
authors.lastname: Dong
mesh_terms: D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011312:Pressure; D012984:Software; D013314:Stress, Mechanical; D014715:Vertebrobasilar Insufficiency / Q000503:physiopathology*