title: Successful Treatment of Macroglossia Due to Lymphatic Malformation With Sirolimus.
abstract: OBJECTIVE
  To evaluate the effectiveness and safety of sirolimus therapy in a child with macroglossia due to lymphatic malformation.
  
  
  METHODS
  Sirolimus treatment was applied to the patient with an initial dosing of 0.8 mg/m2 per dose, administered orally, twice daily at approximately 12-hour intervals.
  
  
  RESULTS
  After 9 months of sirolimus therapy, there was a nearly complete resolution of lymphatic malformation. The last evaluation was performed 6 months after withdrawal of treatment, and the lesion had almost completely resolved.
  
  
  CONCLUSIONS
  This article presents a novel approach to the treatment of lymphatic malformation of the tongue using sirolimus, which appears to be safe and effective for the management of complex cases.
authors.affiliation: Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey syesil2003@yahoo.com.
authors.forename: Sule
authors.initials: S
authors.lastname: Yesil
authors.affiliation: Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Bozkurt
authors.affiliation: Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors.forename: Hikmet Gülsah
authors.initials: HG
authors.lastname: Tanyildiz
authors.affiliation: Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors.forename: Sibel Akpinar
authors.initials: SA
authors.lastname: Tekgunduz
authors.affiliation: Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors.forename: Mehmet Onur
authors.initials: MO
authors.lastname: Candir
authors.affiliation: Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Toprak
authors.affiliation: Dr Sami Ulus Maternity and Children Research and Training Hospital, Ankara, Turkey.
authors.forename: Gurses
authors.initials: G
authors.lastname: Sahin
mesh_terms: D000284:Administration, Oral; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007223:Infant; D044148:Lymphatic Abnormalities / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D008260:Macroglossia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D020123:Sirolimus / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D020123:Sirolimus
keywords: lymphatic malformation; macroglossia; sirolimus