title: Effect of lycopene against gastroesophageal reflux disease in experimental animals.
abstract: BACKGROUND
  Lycopene is a robust antioxidant with significant antiulcer activity. Henceforth, the present study was ventured to elucidate the effect of lycopene on experimental esophagitis.
  
  
  METHODS
  Groups of rats were subjected to forestomach and pylorus ligation with subsequent treatment with lycopene (50 and 100 mg/kg, po) and pantoprazole (30 mg/kg, po).
  
  
  RESULTS
  Treatment with lycopene evidenced sententious physiological protection when scrutinized for pH, acidity (total and free), volume of gastric juices and esophagitis index. Lycopene further embarked diminishing effect on oxidative stress through synchronising lipid and protein peroxidation along with regulating the enzymatic activity of SOD and catalase. Lycopene also modified the levels of immunoregulatory cytokines (IL- 1β and IL-6) favourably. The dose dependent efficacy of lycopene in the current experimental condition was also attested when exemplified morphologically through scanning electron microscopy.
  
  
  CONCLUSIONS
  From the current line of evidences, it was concluded that lycopene can impart momentous protection against experimental esophagitis by wrapping up the reactive oxygen species and through dual inhibition of the arachidonic acid pathway.
authors.affiliation: Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Lucknow, 226 025, UP, India. arvind.mankapur@gmail.com.
authors.forename: Arvind Kumar
authors.initials: AK
authors.lastname: Giri
authors.affiliation: Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Lucknow, 226 025, UP, India. rawat350@gmail.com.
authors.forename: Jitendra Kumar
authors.initials: JK
authors.lastname: Rawat
authors.affiliation: Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Lucknow, 226 025, UP, India. manjari.leo3@gmail.com.
authors.forename: Manjari
authors.initials: M
authors.lastname: Singh
authors.affiliation: Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Lucknow, 226 025, UP, India. swetlana.09@gmail.com.
authors.forename: Swetlana
authors.initials: S
authors.lastname: Gautam
authors.affiliation: Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University, Raebareli Road, Lucknow, 226 025, UP, India. gauravpharm@hotmail.com.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kaithwas
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D002338:Carotenoids / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism; D004941:Esophagitis / Q000378:metabolism / Q000517:prevention & control*; D005750:Gastric Juice / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D000077276:Lycopene; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D000077402:Pantoprazole; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D017208:Rats, Wistar
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000975:Antioxidants; D053583:Interleukin-1beta; D015850:Interleukin-6; D010936:Plant Extracts; D054328:Proton Pump Inhibitors; D002338:Carotenoids; D000077402:Pantoprazole; D002374:Catalase; D000077276:Lycopene