title: Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease.
abstract: Genetic variants in pre-microRNA (miRNA) genes or the 3'UTR of miRNA target genes could influence miRNA-mediated regulation of gene expression and thus contribute to the susceptibility and prognosis of human diseases. This study aimed to investigate the effect of 6 miRNA-related polymorphisms (miR-149 rs71428439, miR-146a rs2910164, miR-499 rs3746444, miR-423 rs6505162, miR-4513 rs2168518, and FABP2 rs11724758) on prognosis in 1004 patients with angiographic coronary artery disease (CAD). We found that miR-4513 rs2168518 was associated with blood pressure, triglycerides, total cholesterol, and fasting glucose levels, and risk of diabetes mellitus. miR-499 rs3746444 and miR-423 rs6505162 were associated with blood pressure and HDL levels, respectively. Both miR-4513 rs2168518 and miR-499 rs3746444 had significant impact on even-free survival. Furthermore, miR-4513 rs2168518 was associated with higher morality in CAD patients. In conclusion, miR-4513 rs2168518 and miR-499 rs3746444 might be potential biomarkers for the clinical prognosis of CAD.
authors.affiliation: Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University Fujian 350001, China.
authors.forename: Qianzhen
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University Fujian 350001, China.
authors.forename: Liangwan
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University Fujian 350001, China.
authors.forename: Daozhong
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University Fujian 350001, China.
authors.forename: Xijie
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University Fujian 350001, China.
authors.forename: Meifang
authors.initials: M
authors.lastname: Chen
keywords: Coronary artery disease; cardiovascular event; lipid; microRNA; mortality; polymorphism