title: The impact of diet on asthma and allergic diseases.
abstract: The incidence of allergic diseases is increasing, both in developed and developing countries, concomitantly with the rise in living standards and the adoption of a 'western lifestyle'. For two decades, the hygiene hypothesis - which proposes that the lack of early childhood exposure to infectious agents increases susceptibility to allergic diseases in later life - provided the conceptual framework for unravelling the mechanisms that could account for the increased incidence of allergic diseases. In this Review, we discuss recent evidence that highlights the role of diet as a key factor influencing immune homeostasis and the development of allergic diseases through a complex interplay between nutrients, their metabolites and immune cell populations. Although further investigations are still required to understand these complex relationships, recent data have established a possible connection between metabolic homeostasis and allergic diseases.
authors.affiliation: 1] Centre Nationale de la Recherche Scientifique (CNRS) Unité mixte de Recherche 7275, 06560 Valbonne, France. [2] Institut National de la santé et de la recherche médicale (Inserm) U1080, France. [3] University of Nice Sophia-Antipolis, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Julia
authors.affiliation: Department of Immunology, Monash University, Clayton, Victoria 3800, Australia.
authors.forename: Laurence
authors.initials: L
authors.lastname: Macia
authors.affiliation: 1] Inserm U1011, France. [2] Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019 Lille cedex, France. [3] Lille 2 University, Lille, France. [4] European Genomic Institute for Diabetes, Lille, France.
authors.forename: David
authors.initials: D
authors.lastname: Dombrowicz
mesh_terms: D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000276:immunology*; D001942:Breast Feeding; D004032:Diet; D005502:Food; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D061148:Hygiene Hypothesis; D006967:Hypersensitivity / Q000276:immunology*; D007107:Immune System / Q000276:immunology*; D009765:Obesity / Q000276:immunology
chemical_list: D000485:Allergens