title: Serum and Saliva MMP-3 in Patients with OLP and Oral SCC.
abstract: Matrix metalloproteinase-3 (MMP-3) plays a key role in development of cancer. The purpose of this study was to assess MMP-3 in the serum and saliva of patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC).
  
  
  
  Thirty patients with OLP (8 reticular and 22 erosive forms), and 20 patients with OSCC (6 in low stage and 14 in advanced stage), were enrolled in this study, conducted at the Cancer Department, Clinic of Oral Medicine, Tehran University of Medical Sciences. The serum and saliva MMP-3 was assayed by ELISA method. Statistical analysis of the Student's t-test, ANOVA and Pearson correlation coefficient was performed. The mean saliva and serum levels of MMP-3 were significantly higher in patients with OSCC compared with OLP.
  
  
  
  The serum and saliva MMP-3 concentrations increased from reticular form of OLP to erosive form of OLP, and increased further to low stage of OSCC and advanced stage of OSCC. Serum MMP-3 correlated significantly with unstimulated (r = 0.310, p = 0.038) and stimulated (r = 0.365, p < 0.026) saliva MMP-3.
  
  
  
  Serum and saliva MMP-3 levels appear associated with OLP and OSCC.
authors.affiliation: Department of Oral Medicine/Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran, Phone: +98-21-66402095, e-mail: aghahose@sina.tums.ac.ir.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Agha-Hosseini
authors.affiliation: Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Mirzaii-Dizgah
authors.affiliation: Department of Oral Medicine/Dental Research Center School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Nima
authors.initials: N
authors.lastname: Mahboobi
authors.affiliation: Department of Oral Medicine/Dental Research Center School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Shiva
authors.initials: S
authors.lastname: Shirazian
authors.affiliation: Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Iraj
authors.initials: I
authors.lastname: Harirchi
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000201:enzymology*; D005260:Female; D005882:Gingival Diseases / Q000097:blood / Q000201:enzymology; D006801:Humans; D017676:Lichen Planus, Oral / Q000097:blood / Q000201:enzymology*; D008048:Lip Neoplasms / Q000097:blood / Q000201:enzymology; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000032:analysis / Q000097:blood*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood / Q000201:enzymology*; D009367:Neoplasm Staging; D012463:Saliva / Q000201:enzymology*; D014060:Tongue Diseases / Q000097:blood / Q000201:enzymology; D014062:Tongue Neoplasms / Q000097:blood / Q000201:enzymology
chemical_list: C511768:MMP3 protein, human; D019278:Matrix Metalloproteinase 3
keywords: MMP-3; Oral lichen planus; Squamous cell carcinoma; Saliva