title: Effects of sodium butyrate on aversive memory in rats submitted to sepsis.
abstract: Epigenetic mechanisms are involved in normal behavior and are implicated in several brain neurodegenerative conditions, psychiatric and inflammatory diseases as well. Moreover, it has been demonstrated that sepsis lead to an imbalance in acetylation of histones and that histone deacetylase inhibitors (HDACi) can reverse this condition. In the present study, we evaluated the effects of a microinjection of sodium butyrate (SB, HDACi) into cerebral ventricle on aversive memory in rats submitted to the sepsis. Rats were given a single intraventricular injection of artificial cerebrospinal fluid (ACSF) or SB and immediately after the stereotaxic surgery and the drug infusion, the animals were subjected to cecal ligation and perforation (CLP). The animals were killed twenty four hours or ten days after sepsis induction and the prefrontal cortex, hippocampus, striatum and cortex were obtained to the determination of histone deacetylase activity. In a separate cohort of animals 10 days after sepsis induction, it was performed the inhibitory avoidance task. SB administration was able to reverse the impairment in aversive memory and inhibited the HDAC activity in prefrontal cortex and hippocampus 10 days after CLP. These support a role for an epigenetic mechanism in the long-term cognitive impairments observed in sepsis survivors animals.
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors.forename: Amanda V
authors.initials: AV
authors.lastname: Steckert
authors.affiliation: Laboratory of Experimental Neurosciences, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil.
authors.forename: Clarissa M
authors.initials: CM
authors.lastname: Comim
authors.affiliation: Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors.forename: Dhébora M Dall
authors.initials: DM
authors.lastname: Igna
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors.forename: Diogo
authors.initials: D
authors.lastname: Dominguini
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors.forename: Bruna P
authors.initials: BP
authors.lastname: Mendonça
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
authors.forename: Felipe
authors.initials: F
authors.lastname: Ornell
authors.affiliation: Laboratory of Molecular Psychiatry and National Institute for Translational Medicine (INCT-TM), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Gabriela D
authors.initials: GD
authors.lastname: Colpo
authors.affiliation: Laboratory of Molecular Psychiatry and National Institute for Translational Medicine (INCT-TM), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Carolina
authors.initials: C
authors.lastname: Gubert
authors.affiliation: Laboratory of Molecular Psychiatry and National Institute for Translational Medicine (INCT-TM), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Flávio
authors.initials: F
authors.lastname: Kapczinski
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil; Center for Experimental Models in Psychiatry, Department of Psychiatry and Behavioral Sciences, Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Barichello
authors.affiliation: Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil; Center for Experimental Models in Psychiatry, Department of Psychiatry and Behavioral Sciences, Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
authors.affiliation: Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil. Electronic address: fdpizzol@gmail.com.
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
mesh_terms: D000818:Animals; D020148:Butyric Acid / Q000627:therapeutic use*; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use*; D006655:Histone Deacetylases / Q000378:metabolism; D007276:Injections, Intraventricular; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D008845:Microinjections; D017397:Prefrontal Cortex / Q000187:drug effects / Q000201:enzymology; D017208:Rats, Wistar; D018805:Sepsis / Q000150:complications* / Q000201:enzymology
chemical_list: D056572:Histone Deacetylase Inhibitors; D020148:Butyric Acid; D006655:Histone Deacetylases
keywords: Brain; Histone deacetylase; Memory; Sepsis; Sodium butyrate