title: Effect of desmopressin administration on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery: a randomized, clinical trial.
abstract: BACKGROUND
  Bleeding during functional endoscopic sinus surgery is a challenge for the quality of the surgical field for surgeons. This study aimed to evaluate the effect of desmopressin premedication on blood loss and the quality of the surgical field in endoscopic sinus surgery.
  
  
  METHODS
  A total of 90 American Society of Anesthesiologists physical status I-II patients underwent endoscopic sinus surgery for chronic sinusitis. They were randomly allocated to receive either desmopressin 0.3 μg/kg or saline before the operation. Management of anesthesia was achieved with propofol and remifentanil infusions, with moderate, controlled hypotension. Blood loss and quality of the surgical field were assessed after surgery. Effects of desmopressin on anesthetic requirements and hemodynamic variables were analyzed.
  
  
  RESULTS
  Blood loss was significantly less in the desmopressin group (mean ± SD, 42 ± 8.7 ml) than in the control group (70 ± 9.2 ml, P < 0.001). Surgeons were more satisfied with the surgical field in the desmopressin group than in the control group (median score, 4 [3-5] vs. 7 [6-9], P < 0.001). Requirements for remifentanil and esmolol were lower in the desmopressin group than in the control group.
  
  
  CONCLUSIONS
  Premedication with desmopressin 0.3 μg/kg can effectively reduce bleeding during endoscopic sinus surgery.
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. 13580482938@139.com.|Department of Anesthesiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. 13580482938@139.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Shao
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. 369512714@qq.com.
authors.forename: Li-Ting
authors.initials: LT
authors.lastname: Kuang
authors.affiliation: Otorhinolaryngology Hospital, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China. 13600083975@139.com.
authors.forename: Wei-Jian
authors.initials: WJ
authors.lastname: Hou
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. 11139398@qq.com.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006490:Hemostatics / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage; D015742:Propofol / Q000008:administration & dosage; D011446:Prospective Studies; D000077208:Remifentanil; D016037:Single-Blind Method; D012852:Sinusitis / Q000601:surgery*; D055815:Young Adult
chemical_list: D006490:Hemostatics; D010880:Piperidines; D003894:Deamino Arginine Vasopressin; D000077208:Remifentanil; D015742:Propofol