title: A luminescent cyclometalated gold(iii)-avidin conjugate with a long-lived emissive excited state that binds to proteins and DNA and possesses anti-proliferation capacity.
abstract: Here we describe a luminescent cyclometalated Au(iii)-avidin conjugate that exhibits a 520 nm emission with a lifetime of 1.8 μs in PBS solution in open air. The conjugate stains proteins and DNA and can inhibit cancer cell proliferation.
authors.affiliation: State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Center and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China. cmche@hku.hk.
authors.forename: Johnson Lui-Lui
authors.initials: JL
authors.lastname: Tsai
authors.forename: Anna On-Yee
authors.initials: AO
authors.lastname: Chan
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001360:Avidin / Q000737:chemistry* / Q000494:pharmacology; D001710:Biotin / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001360:Avidin; D012710:Serum Albumin, Bovine; D001710:Biotin; D006046:Gold; D004247:DNA