title: Life after MOMP.
abstract: In this and a recent issue of Molecular Cell, Liu et al. (2015) and Ichim et al. (2015) report that low levels of caspase activity triggered by limited mitochondrial outer membrane permeabilization (MOMP) promote genomic instability that drives tumorigenesis, providing a novel and unexpected link between these effectors of apoptosis and cancer initiation.
authors.affiliation: Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Vivian
authors.initials: V
authors.lastname: Gama
authors.affiliation: Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: mohanish@med.unc.edu.
authors.forename: Mohanish
authors.initials: M
authors.lastname: Deshmukh
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D004249:DNA Damage; D042822:Genomic Instability; D006801:Humans; D051336:Mitochondrial Membranes / Q000502:physiology*