title: CNTNAP3 associated ATG16L1 expression and Crohn's disease.
abstract: Autophagy is a common physiological process in cell homeostasis and regulation. Autophagy-related gene mutations and autophagy disorders are important in Crohn's disease (CD). The nucleotide oligomerization domain 2-autophagy genes autophagy 16-like 1 (NOD2-ATG16L1) signaling axis disorder contributes to the dysfunction of autophagy. This paper is focused on the relationship between contactin associated protein-like 3 (CNTNAP3) and ATG16L1 expression in Crohn's disease. The results indicated that the expression of ATG16L1 is higher in some CD patients compared to normal controls. ATG16L1 was well correlated with the C-reactive protein (CRP) in some CD patients. In vitro study revealed that CNTNAP3 could upregulate the expression of ATG16L1 and increase autophagy vacuoles.
authors.affiliation: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China ; Shanghai Institute of Digestive Disease, Shanghai 200127, China ; Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China ; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiao Tong University), Shanghai 200127, China.
authors.forename: Yu Qi
authors.identifier: 0000-0002-0374-5089
authors.initials: YQ
authors.lastname: Qiao
authors.affiliation: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China ; Shanghai Institute of Digestive Disease, Shanghai 200127, China ; Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China ; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiao Tong University), Shanghai 200127, China.
authors.forename: Mei Lan
authors.initials: ML
authors.lastname: Huang
authors.affiliation: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China ; Shanghai Institute of Digestive Disease, Shanghai 200127, China ; Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China ; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiao Tong University), Shanghai 200127, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zheng
authors.affiliation: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China ; Shanghai Institute of Digestive Disease, Shanghai 200127, China ; Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China ; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiao Tong University), Shanghai 200127, China.
authors.forename: Tian Rong
authors.initials: TR
authors.lastname: Wang
authors.affiliation: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China ; Shanghai Institute of Digestive Disease, Shanghai 200127, China ; Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China ; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiao Tong University), Shanghai 200127, China.
authors.forename: An Tao
authors.initials: AT
authors.lastname: Xu
authors.affiliation: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China ; Shanghai Institute of Digestive Disease, Shanghai 200127, China ; Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China ; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiao Tong University), Shanghai 200127, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China ; Shanghai Institute of Digestive Disease, Shanghai 200127, China ; Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China ; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiao Tong University), Shanghai 200127, China.
authors.forename: Di
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China ; Shanghai Institute of Digestive Disease, Shanghai 200127, China ; Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China ; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiao Tong University), Shanghai 200127, China.
authors.forename: Zhi Hua
authors.initials: ZH
authors.lastname: Ran
authors.affiliation: Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China ; Shanghai Institute of Digestive Disease, Shanghai 200127, China ; Shanghai Inflammatory Bowel Disease Research Center, Shanghai 200127, China ; Key Laboratory of Gastroenterology & Hepatology, Ministry of Health (Shanghai Jiao Tong University), Shanghai 200127, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Shen
mesh_terms: D000328:Adult; D001343:Autophagy; D000071183:Autophagy-Related Proteins; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D002097:C-Reactive Protein / Q000378:metabolism; D002103:Cadaverine / Q000031:analogs & derivatives / Q000737:chemistry; D002352:Carrier Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D003424:Crohn Disease / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000378:metabolism; D012307:Risk Factors
chemical_list: C518959:ATG16L1 protein, human; D000071183:Autophagy-Related Proteins; D015415:Biomarkers; C464567:CNTNAP3 protein, human; D002352:Carrier Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D002097:C-Reactive Protein; C008542:monodansylcadaverine; D002103:Cadaverine