title: A bio-inspired stimulator to desynchronize epileptic cortical population models: A digital implementation framework.
abstract: Pathophysiologic neural synchronization is a hallmark of several neurological disorders such as epilepsy. In addition, based on established neurophysiologic findings, astrocytes dynamically regulate the synaptic transmission and have key roles in stabilizing neural synchronization. Therefore, in the present study, based on the dynamic model of astrocyte, a digital bio-inspired stimulator is proposed to avoid the hyper-synchronous seizure-like activities in a cortical population model. The complete digital circuit of the close loop system that is the bio-inspired stimulator and the cortical population model are implemented in hardware on the ZedBoard development kit. Based on the results of MATLAB simulations, hardware synthesis and FPGA implementation, it is demonstrated that the digital bio-inspired stimulator can effectively prevent the occurrence of spontaneous paroxysmal episodes with a demand-controlled characteristic. In this way, the designed digital stimulator successfully maintains the normal ongoing activity.
authors.affiliation: Department of Electronic, College of Engineering, Kermanshah Science and Research Branch, Islamic Azad University, Kermanshah, Iran; Department of Electronic, College of Engineering, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Piri
authors.affiliation: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Amiri
authors.affiliation: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: ma.amiri@ece.ut.ac.ir.
authors.forename: Mahmood
authors.initials: M
authors.lastname: Amiri
mesh_terms: D001253:Astrocytes / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000503:physiopathology*; D003198:Computer Simulation; D003201:Computers; D004827:Epilepsy / Q000503:physiopathology*; D004867:Equipment Design; D006801:Humans; D008564:Membrane Potentials; D008959:Models, Neurological; D009434:Neural Pathways / Q000503:physiopathology; D009474:Neurons; D017966:Pyramidal Cells; D009435:Synaptic Transmission; D013788:Thalamus / Q000503:physiopathology
keywords: DBS; Epilepsy; Hardware implementation; Neural population model; Synchronization