title: [Synthesis of a fluorescent analog of methotrexate lipophilic prodrug].
abstract: A fluorescent analog of the lipophilic prodrug of antitumor agent methotrexate has been synthesized. The conjugate consists of a residue of rac-1-[13-(Me4-BODIPY-8)tridecanoyl]-2-oleoylglycerol connected to methotrexate by ester bond via β-Ala-N-carbonylmethylene linker (Me4-BODIPY-8,4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacen-8-yl). The probe is designed for incorporation in the membrane of liposomal vehicle to study a mechanism of interaction with tumor cells and an intracellular traffic.
authors.forename: Yu V
authors.initials: YV
authors.lastname: Ylasenko
authors.forename: A S
authors.initials: AS
authors.lastname: Alekseeva
authors.forename: E L
authors.initials: EL
authors.lastname: Vodovozova
mesh_terms: D001896:Boron Compounds / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D005456:Fluorescent Dyes / Q000138:chemical synthesis; D005989:Glycerides / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008727:Methotrexate / Q000138:chemical synthesis / Q000737:chemistry*; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D005989:Glycerides; D008081:Liposomes; D011355:Prodrugs; C505247:2-oleoylglycerol; D008727:Methotrexate