title: Alternative mechanisms for O2 release and O-O bond formation in the oxygen evolving complex of photosystem II.
abstract: In a previous detailed study of all the steps of water oxidation in photosystem II, it was surprisingly found that O2 release is as critical for the rate as O-O bond formation. A new mechanism for O2 release has now been found, which can be described as an opening followed by a closing of the interior of the oxygen evolving complex. A transition state for peroxide rotation forming a superoxide radical, missed in the previous study, and a structural change around the outside manganese are two key steps in the new mechanism. However, O2 release may still remain rate-limiting. Additionally, for the step forming the O-O bond, an alternative, experimentally suggested, mechanism was investigated. The new model calculations can rule out the precise use of that mechanism. However, a variant with a rotation of the ligands around the outer manganese by about 30° will give a low barrier, competitive with the old DFT mechanism. Both these mechanisms use an oxyl-oxo mechanism for O-O bond formation involving the same two manganese atoms and the central oxo group (O5).
authors.affiliation: College of Chemistry, Beijing Normal University, 100875, Beijing, China.
authors.forename: Xichen
authors.initials: X
authors.lastname: Li
authors.forename: Per E M
authors.initials: PE
authors.lastname: Siegbahn
mesh_terms: D008345:Manganese / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism*; D045332:Photosystem II Protein Complex / Q000737:chemistry / Q000378:metabolism*; D011789:Quantum Theory; D013816:Thermodynamics; D014867:Water / Q000378:metabolism*
chemical_list: D045332:Photosystem II Protein Complex; D014867:Water; D008345:Manganese; D010100:Oxygen