title: MIDA: A Multimodal Imaging-Based Detailed Anatomical Model of the Human Head and Neck.
abstract: Computational modeling and simulations are increasingly being used to complement experimental testing for analysis of safety and efficacy of medical devices. Multiple voxel- and surface-based whole- and partial-body models have been proposed in the literature, typically with spatial resolution in the range of 1-2 mm and with 10-50 different tissue types resolved. We have developed a multimodal imaging-based detailed anatomical model of the human head and neck, named "MIDA". The model was obtained by integrating three different magnetic resonance imaging (MRI) modalities, the parameters of which were tailored to enhance the signals of specific tissues: i) structural T1- and T2-weighted MRIs; a specific heavily T2-weighted MRI slab with high nerve contrast optimized to enhance the structures of the ear and eye; ii) magnetic resonance angiography (MRA) data to image the vasculature, and iii) diffusion tensor imaging (DTI) to obtain information on anisotropy and fiber orientation. The unique multimodal high-resolution approach allowed resolving 153 structures, including several distinct muscles, bones and skull layers, arteries and veins, nerves, as well as salivary glands. The model offers also a detailed characterization of eyes, ears, and deep brain structures. A special automatic atlas-based segmentation procedure was adopted to include a detailed map of the nuclei of the thalamus and midbrain into the head model. The suitability of the model to simulations involving different numerical methods, discretization approaches, as well as DTI-based tensorial electrical conductivity, was examined in a case-study, in which the electric field was generated by transcranial alternating current stimulation. The voxel- and the surface-based versions of the models are freely available to the scientific community.
authors.affiliation: Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America.
authors.forename: Maria Ida
authors.initials: MI
authors.lastname: Iacono
authors.affiliation: IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland.
authors.forename: Esra
authors.initials: E
authors.lastname: Neufeld
authors.affiliation: Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America.
authors.forename: Esther
authors.initials: E
authors.lastname: Akinnagbe
authors.affiliation: Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America.
authors.forename: Kelsey
authors.initials: K
authors.lastname: Bower
authors.affiliation: IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland; Swiss Federal Institute of Technology (ETH) Zurich, 8092 Zurich, Switzerland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Wolf
authors.affiliation: IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland; Swiss Federal Institute of Technology (ETH) Zurich, 8092 Zurich, Switzerland.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vogiatzis Oikonomidis
authors.affiliation: IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland; Swiss Federal Institute of Technology (ETH) Zurich, 8092 Zurich, Switzerland.
authors.forename: Deepika
authors.initials: D
authors.lastname: Sharma
authors.affiliation: IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland.
authors.forename: Bryn
authors.initials: B
authors.lastname: Lloyd
authors.affiliation: Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
authors.forename: Bertram J
authors.initials: BJ
authors.lastname: Wilm
authors.affiliation: Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Wyss
authors.affiliation: Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland.
authors.forename: Klaas P
authors.initials: KP
authors.lastname: Pruessmann
authors.affiliation: Computational Imaging Research Laboratory, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria; Computer Vision Laboratory, ETH Zurich, Zurich, Switzerland.
authors.forename: Andras
authors.initials: A
authors.lastname: Jakab
authors.affiliation: Athinoula A. Martinos Center For Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, 02129, United States of America; Center for Morphometric Analysis, Department of Psychiatry and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, 02129, United States of America.
authors.forename: Nikos
authors.initials: N
authors.lastname: Makris
authors.affiliation: Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America.
authors.forename: Ethan D
authors.initials: ED
authors.lastname: Cohen
authors.affiliation: IT'IS Foundation for Research on Information Technologies in Society, Zurich, Switzerland; Swiss Federal Institute of Technology (ETH) Zurich, 8092 Zurich, Switzerland.
authors.forename: Niels
authors.initials: N
authors.lastname: Kuster
authors.affiliation: Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kainz
authors.affiliation: Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, 20993, United States of America.
authors.forename: Leonardo M
authors.initials: LM
authors.lastname: Angelone
mesh_terms: D016880:Anisotropy; D001931:Brain Mapping; D003198:Computer Simulation; D056324:Diffusion Tensor Imaging; D006257:Head / Q000033:anatomy & histology* / Q000098:blood supply; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008636:Mesencephalon / Q000033:anatomy & histology / Q000098:blood supply; D020644:Midline Thalamic Nuclei / Q000033:anatomy & histology / Q000098:blood supply; D008953:Models, Anatomic; D064847:Multimodal Imaging; D009333:Neck / Q000033:anatomy & histology* / Q000098:blood supply / Q000294:innervation