title: Comparison of pathological data between prostate biopsy and radical prostatectomy specimen in patients with low to very low risk prostate cancer.
abstract: OBJECTIVE
  To analyze the correlation between pathological data found in radical prostatectomy and previously performed biopsy in patients at low risk prostate cancer.
  
  
  METHODS
  A descriptive, cross-sectional study was conducted to assess the characteristics of radical prostatectomies performed in our center from January 2012 to November 2014. The inclusion criteria were patients with low-risk disease (cT1c-T2a, PSA≤10ng/mL and Gleason score≤6). We excluded patients who had fewer than 8 cores in the biopsy, an unspecified number of affected cores, rectal examinations not reported in the medical history or biopsies performed in another center.
  
  
  RESULTS
  Of the 184 patients who underwent prostatectomy during this period, 87 met the inclusion criteria, and 26 of these had<3 affected cores and PSA density≤.15 (very low risk). In the entire sample, the percentage of undergrading (Gleason score≥7) and extracapsular invasion (pT3) was 18.4% (95% CI 10.3-27.6) and 10.35% (95% CI 4.6-17.2), respectively. The percentage of positive margins was 21.8% (95% CI 12.6-29.9). In the very low-risk group, we found no cases of extracapsular invasion and only 1 case of undergrading (Gleason 7 [3+4]), representing 3.8% of the total (95% CI 0-12.5). Predictors of no correlation (stage≥pT3a or undergrading) were the initial risk group, volume, PSA density and affected cores.
  
  
  CONCLUSIONS
  Prostate volume, PSA density, the number of affected cores and the patient's initial risk group influence the poor pathological prognosis in the radical prostatectomy specimen (extracapsular invasion and Gleason score≥7).
authors.affiliation: Servicio de Urología, Consorcio Sanitario Público Aljarafe, Hospital San Juan de Dios del Aljarafe, Bormujos, Sevilla, España. Electronic address: glendinez@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Lendínez-Cano
authors.affiliation: Servicio de Urología, Consorcio Sanitario Público Aljarafe, Hospital San Juan de Dios del Aljarafe, Bormujos, Sevilla, España.
authors.forename: J
authors.initials: J
authors.lastname: Alonso-Flores
authors.affiliation: Servicio de Urología, Consorcio Sanitario Público Aljarafe, Hospital San Juan de Dios del Aljarafe, Bormujos, Sevilla, España.
authors.forename: V
authors.initials: V
authors.lastname: Beltrán-Aguilar
authors.affiliation: Servicio de Atención al Usuario y Calidad, Consorcio Sanitario Público Aljarafe, Hospital San Juan de Dios del Aljarafe, Sevilla, España; Unidad de Salud Pública, Área Sur de Sevilla, Hospital de Valme , Sevilla, España.
authors.forename: A
authors.initials: A
authors.lastname: Cayuela
authors.affiliation: Servicio de Urología, Consorcio Sanitario Público Aljarafe, Hospital San Juan de Dios del Aljarafe, Bormujos, Sevilla, España.
authors.forename: S
authors.initials: S
authors.lastname: Salazar-Otero
authors.affiliation: Servicio de Urología, Consorcio Sanitario Público Aljarafe, Hospital San Juan de Dios del Aljarafe, Bormujos, Sevilla, España.
authors.forename: J
authors.initials: J
authors.lastname: Bachiller-Burgos
mesh_terms: D001706:Biopsy; D003430:Cross-Sectional Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology*; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D018570:Risk Assessment
keywords: Bajo riesgo; Biopsia; Biopsy; Cáncer de próstata; Low risk; Muy bajo riesgo; Prostate cancer; Prostatectomía radical; Radical prostatectomy; Very Low risk