title: Bilateral endogenous endophthalmitis caused by vancomycin-resistant Staphylococcus epidermidis in a neonate.
abstract: BACKGROUND
  Neonatal bilateral endogenous endophthalmitis is rare and often results in devastating visual outcome.
  
  
  RESULTS
  An 18-day-old neonate presented with whitening of the cornea in the left eye. The child was examined under anesthesia, and a diagnosis of bilateral endogenous endophthalmitis was made. Vitreous biopsy from the left eye showed no growth. Blood samples showed growth of Staphylococcus epidermidis which was multidrug resistant (including vancomycin) but sensitive to piperacillin-tazobactam. The patient was managed with bilateral intravitreal injections of piperacillin-tazobactam and systemic cefpodoxime. Systemic and topical antibiotics were given for 3 and 8 weeks, respectively, and infection was controlled. At 2-year follow-up, the right eye is fixing and following to light with clear view of the fundus and the left eye has a clear cornea with red glow of the fundus.
  
  
  CONCLUSIONS
  Vancomycin-resistant S. epidermidis may be a cause of endogenous endophthalmitis. Intravitreal piperacillin-tazobactam and systemic cefpodoxime were used to eliminate the infection in this neonate.
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136 USA ; Kode Venkatadri Chowdry Campus, Tadigadapa, Vijayawada, 521137 Andhra Pradesh India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Relhan
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136 USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Albini
authors.affiliation: Kode Venkatadri Chowdry Campus, Tadigadapa, Vijayawada, 521137 Andhra Pradesh India ; Retina and Uveitis Department, L V Prasad Eye Institute, GMR Varalakshmi Campus, Visakhapatnam, 530040 India.
authors.forename: Avinash
authors.initials: A
authors.lastname: Pathengay
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136 USA.
authors.forename: Harry W
authors.initials: HW
authors.lastname: Flynn
keywords: Endogenous endophthalmitis; Neonatal endophthalmitis; Vancomycin resistance