title: Pupil function as an indicator of being under the influence of central nervous system-acting substances from a traffic-medicine perspective - Part II.
abstract: In order to evaluate driving abilities of each traffic participant, standardised and objective measurement methods are needed. The applicability and value of infrared pupillography as an objective measurement method to indicate possible influence of central nervous acting substances has been demonstrated in former publications. Healthy test subjects (n = 41), as well as persons who were under the influence of drugs and/or medication (n = 105), were exposed to different light stimuli using infrared technology in order to demonstrate the relevance of specific parameters of the pupillary light reflex (PLR) in the field of traffic medicine. Based on former reported results, the statistical examination was extended to further parameters of the PLR, which again confirmed the high value of infrared pupillography as a reliable indicator of previous consumption of drugs and/or medication.
authors.affiliation: Institute of Forensic Medicine, Paris Lodron University Salzburg, Austria fabio.monticelli@sbg.ac.at.
authors.forename: Fabio
authors.initials: F
authors.lastname: Monticelli
authors.affiliation: Forensic Medicine, Laboratoire national de Santé, Luxembourg.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Preiss
authors.affiliation: Biostatistics, Paracelsus Medical University, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hitzl
authors.affiliation: Institute of Forensic Medicine, Paris Lodron University Salzburg, Austria.
authors.forename: Thomas
authors.initials: T
authors.lastname: Keller
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002491:Central Nervous System Agents / Q000097:blood / Q000494:pharmacology*; D000066448:Driving Under the Influence; D053593:Forensic Toxicology; D006801:Humans; D007259:Infrared Rays; D015233:Models, Statistical; D012025:Reflex, Pupillary; D015813:Substance Abuse Detection / Q000295:instrumentation / Q000379:methods*
chemical_list: D002491:Central Nervous System Agents
keywords: expert witness; forensic medicine; forensic pathology; medical; toxicology