title: Clinical significance of melanoma-associated antigen A1-6 expression in sputum of patients with squamous cell carcinoma of the larynx and hypopharynx.
abstract: Several studies have reported the expression of the melanoma-associated antigen (MAGE) gene in head and neck squamous cell carcinoma (HNSCC). In this study, we evaluated the correlations between MAGE expression in sputum and the clinical features and oncologic outcomes of SCC of the larynx and hypopharynx.
  
  
  
  We performed a retrospective review of 119 patients treated for SCC of the larynx and hypopharynx and analysis of their induced sputum by nested reverse transcription-polymerase chain reaction (RT-PCR) to detect the MAGE-A1-6 gene. The associations between MAGE expression and clinical characteristics were analyzed.
  
  
  
  Expression of MAGE-A1-6 in sputum was identified in 57 of 119 patients (47.9%), and was independently correlated to double primary cancer (p = .024; odds ratio [OR] = 4.135). Expression of MAGE-A1-6 in sputum was correlated to poor survival.
  
  
  
  Expression of MAGE-A1-6 in sputum predicts poor oncologic outcome in patients with SCC of the larynx and hypopharynx. © 2015 Wiley Periodicals, Inc. Head Neck 38: E736-E740, 2016.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Republic of South Korea.
authors.forename: Kang Dae
authors.initials: KD
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Republic of South Korea.
authors.forename: Hyoung Shin
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Republic of South Korea.
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Republic of South Korea.
authors.forename: Taejung
authors.initials: T
authors.lastname: Park
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Dong-A University College of Medicine, Busan, Republic of South Korea.
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Hong
authors.affiliation: Department of Pathology, Kosin University College of Medicine, Busan, Republic of South Korea.
authors.forename: Hee Kyung
authors.initials: HK
authors.lastname: Chang
authors.affiliation: Department of Clinical Pathology, Gimhae College, Busan, Republic of South Korea.
authors.forename: Sang Bong
authors.initials: SB
authors.lastname: Jung
authors.affiliation: Department of Laboratory Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of South Korea.
authors.forename: Chang-Ho
authors.initials: CH
authors.lastname: Jeon
authors.affiliation: Department of Immunology, School of Medicine, Keimyung University, Daegu, Republic of South Korea.
authors.forename: Jong Wook
authors.initials: JW
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D058950:Melanoma-Specific Antigens / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013183:Sputum
chemical_list: C072011:MAGEA1 protein, human; D058950:Melanoma-Specific Antigens
keywords: head and neck cancer; hypopharynx; larynx; melanoma-associated antigen (MAGE); squamous cell carcinoma