title: Serum prolidase levels in Graves' disease without ophthalmopathy and its association with oxidative status.
abstract: OBJECTIVE
  The aim of this study was to evaluate serum prolidase levels and its association with oxidative stress in autoimmune thyroid disease (AITD).
  
  
  METHODS
  25 with Hashimoto thyroiditis (HT) and 25 patients Graves' disease (GD), and 27 healthy controls were enrolled in the study. The patients with signs of Graves' ophthalmopathy were excluded from the study. Serum samples were obtained in euthyroid period at the third month of treatment. Serum prolidase, total antioxidant status (TAS), total oxidative stress (TOS), and total free sulfhydryl (-SH) levels were measured.
  
  
  RESULTS
  Serum prolidase levels were significantly higher in the patients with GD compared to the HT and the healthy control group. Oxidative stress index (OSI) and TOS levels of the patients with both GD and HT were significantly higher compared to those of the control group (p < 0.001, for each), while -SH levels were significantly lower (p < 0.001, for each). There was no significant difference between the patients with HT and healthy control group in terms of prolidase levels (p = 0.580). Prolidase levels were positively correlated with TOS and OSI and negatively correlated with -SH (r = 0.565, p = 0.003; r = 0.604, p = 0.001; r = -0.532, p = 0.006).
  
  
  CONCLUSIONS
  Serum prolidase activity is increased in GD patients without signs of ophthalmopathy, and showed a positive correlation with oxidative stress parameters.
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey. drhkorkmaz@yahoo.com.tr.
authors.forename: H
authors.initials: H
authors.lastname: Korkmaz
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Tabur
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Ozkaya
authors.affiliation: Department of Medical Pharmacology, Faculty of Medicine, Harran University, 63300, Sanliurfa, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Oguz
authors.affiliation: Department of Clinical Biochemistry, Faculty of Medicine, Harran University, 63300, Sanliurfa, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Aksoy
authors.affiliation: Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27100, Sahinbey, Gaziantep, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Akarsu
mesh_terms: D000328:Adult; D004150:Dipeptidases / Q000097:blood*; D005260:Female; D006111:Graves Disease / Q000097:blood*; D050031:Hashimoto Disease / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D013438:Sulfhydryl Compounds / Q000097:blood
chemical_list: D013438:Sulfhydryl Compounds; D004150:Dipeptidases; C022449:proline dipeptidase
keywords: Graves’ disease; Hashimoto’s thyroiditis; Oxidative status; Prolidase