title: Bioresorbable Electronic Stent Integrated with Therapeutic Nanoparticles for Endovascular Diseases.
abstract: Implantable endovascular devices such as bare metal, drug eluting, and bioresorbable stents have transformed interventional care by providing continuous structural and mechanical support to many peripheral, neural, and coronary arteries affected by blockage. Although effective in achieving immediate restoration of blood flow, the long-term re-endothelialization and inflammation induced by mechanical stents are difficult to diagnose or treat. Here we present nanomaterial designs and integration strategies for the bioresorbable electronic stent with drug-infused functionalized nanoparticles to enable flow sensing, temperature monitoring, data storage, wireless power/data transmission, inflammation suppression, localized drug delivery, and hyperthermia therapy. In vivo and ex vivo animal experiments as well as in vitro cell studies demonstrate the previously unrecognized potential for bioresorbable electronic implants coupled with bioinert therapeutic nanoparticles in the endovascular system.
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Donghee
authors.initials: D
authors.lastname: Son
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Jongha
authors.initials: J
authors.lastname: Lee
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Dong Jun
authors.initials: DJ
authors.lastname: Lee
authors.affiliation: §MC10 Inc., 9 Camp Street, Cambridge, Massachusetts 02140, United States.
authors.forename: Roozbeh
authors.initials: R
authors.lastname: Ghaffari
authors.affiliation: ∥School of Electrical and Computer Engineering and INMC, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Sumin
authors.initials: S
authors.lastname: Yun
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Seok Joo
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Lee
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|⊥Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
authors.forename: Hye Rim
authors.initials: HR
authors.lastname: Cho
authors.affiliation: ⊥Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
authors.forename: Soonho
authors.initials: S
authors.lastname: Yoon
authors.affiliation: #Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, Texas Materials Institute, University of Texas at Austin, 210 E. 24th Street, Austin, Texas 78712, United States.
authors.forename: Shixuan
authors.initials: S
authors.lastname: Yang
authors.affiliation: ⊥Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
authors.forename: Seunghyun
authors.initials: S
authors.lastname: Lee
authors.affiliation: #Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, Texas Materials Institute, University of Texas at Austin, 210 E. 24th Street, Austin, Texas 78712, United States.
authors.forename: Shutao
authors.initials: S
authors.lastname: Qiao
authors.affiliation: ∇Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.
authors.forename: Daishun
authors.initials: D
authors.lastname: Ling
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Sanghun
authors.initials: S
authors.lastname: Shin
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Jun-Kyul
authors.initials: JK
authors.lastname: Song
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Jaemin
authors.initials: J
authors.lastname: Kim
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Taeho
authors.initials: T
authors.lastname: Kim
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Hakyong
authors.initials: H
authors.lastname: Lee
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Jonghoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Min
authors.initials: M
authors.lastname: Soh
authors.affiliation: ¶School of Advanced Materials Engineering, Kookmin University, Seoul 136-702, Republic of Korea.
authors.forename: Nohyun
authors.initials: N
authors.lastname: Lee
authors.affiliation: □Department of Materials Science and Engineering and Inter-university Semiconductor Research Center, Seoul National University, Seoul 151-744, Republic of Korea.
authors.forename: Cheol Seong
authors.initials: CS
authors.lastname: Hwang
authors.affiliation: ∥School of Electrical and Computer Engineering and INMC, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Sangwook
authors.initials: S
authors.lastname: Nam
authors.affiliation: #Center for Mechanics of Solids, Structures and Materials, Department of Aerospace Engineering and Engineering Mechanics, Texas Materials Institute, University of Texas at Austin, 210 E. 24th Street, Austin, Texas 78712, United States.
authors.forename: Nanshu
authors.initials: N
authors.lastname: Lu
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Taeghwan
authors.initials: T
authors.lastname: Hyeon
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|⊥Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
authors.forename: Seung Hong
authors.initials: SH
authors.lastname: Choi
authors.affiliation: †Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 151-742, Republic of Korea.|‡School of Chemical and Biological Engineering and Institute of Chemical Processes, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Dae-Hyeong
authors.initials: DH
authors.lastname: Kim
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D004581:Electronics; D004583:Electrons; D057510:Endovascular Procedures; D051379:Mice; D053758:Nanoparticles / Q000627:therapeutic use*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015607:Stents; D014652:Vascular Diseases / Q000628:therapy*
chemical_list: D017382:Reactive Oxygen Species
keywords: bioresorbable; flexible electronics; nanomedicine; stent; transient electronics