title: mRNA expression of somatostatin receptor subtypes SSTR-2, SSTR-3, and SSTR-5 and its significance in pancreatic cancer.
abstract: BACKGROUND
  The aim of this study is to investigate the expressions of somatostatin receptor (SSTR), SSTR-2, SSTR-3, and SSTR-5, in pancreatic tissue and non-cancerous tissue and elucidate their clinical significance.
  
  
  METHODS
  The expression of somatostatin receptor subtypes SSTR-2, SSTR-3, and SSTR-5 messenger RNA (mRNA) in 108 cases of cancer tissue and adjacent tissue in patients with pancreatic cancer was detected by reverse transcriptase polymerase chain reaction (RT-PCR). Expression of SSTR-2, SSTR-3, and SSTR-5 mRNA was evaluated after specimens were taken from selected patients who underwent surgical resection by Whipple's operation. We speculated the clinical significance of the expression of somatostatin receptor (SSTR) subtype genes SSTR-2, SSTR-3, and SSTR-5 in pancreatic tissue and non-cancerous tissue and further elucidated their clinical significance.
  
  
  RESULTS
  The expression rates of SSTR-2 mRNA in cancer and adjacent tissue of 108 patients with pancreatic cancer were 81.5% (88/108) and 97.2% (105/108), respectively; SSTR-3 mRNA expression rates were 69.4% (75/108) and 55.6% (60/108). SSTR-5 mRNA expression rates were 13.0% (14/108) and 18.5% (20/108).
  
  
  CONCLUSIONS
  We propose that SSTR-2 plays an important role in clinical implications for patients with pancreatic cancer undergoing somatostatin or its analog therapy.
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Wenhua west Road #44, Jinan, 250012, China. apexshahbaz@gmail.com.|Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, 250012, Shandong, People's Republic of China. apexshahbaz@gmail.com.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Shahbaz
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Wenhua west Road #44, Jinan, 250012, China. fangruliang@126.com.|Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, 250012, Shandong, People's Republic of China. fangruliang@126.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Ruliang
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Wenhua west Road #44, Jinan, 250012, China. 850897415@qq.com.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xu
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Wenhua west Road #44, Jinan, 250012, China. liangbj127@hotmail.com.|Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, 250012, Shandong, People's Republic of China. liangbj127@hotmail.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Benjia
authors.affiliation: Department of Radiation Oncology, Qilu Hospital, Shandong University, Jinan, 250012, China. wangcong9090@163.com.
authors.forename: Wang
authors.initials: W
authors.lastname: Cong
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Wenhua west Road #44, Jinan, 250012, China. hzbinfo@163.com.
authors.forename: He
authors.initials: H
authors.lastname: Zhaobin
authors.affiliation: Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Wenhua west Road #44, Jinan, 250012, China. sdusurg@gmail.com.
authors.forename: Niu
authors.initials: N
authors.lastname: Jun
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics*; D017481:Receptors, Somatostatin / Q000235:genetics*; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate
chemical_list: D012333:RNA, Messenger; D017481:Receptors, Somatostatin; C574734:SSTR2 protein, human; C103631:somatostatin receptor 3; C094573:somatostatin receptor 5