title: How nanoparticles interact with cancer cells.
abstract: There are currently no nanoparticle formulations that optimally target diseased cells in the body. A small percentage of nanoparticles reach these cells and most accumulate in cells of the mononuclear phagocytic system. This chapter explores the interactions between nanoparticles and cells that may explain the causes for off-target accumulation of nanoparticles. A greater understanding of the nanoparticle-cellular interactions will lead to improvements in particle design for improved therapeutic outcome.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College St., 407, Toronto, ON, M5S 3G9, Canada.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Syed
authors.forename: Warren C W
authors.initials: WC
authors.lastname: Chan
mesh_terms: D000818:Animals; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D058726:Nanoconjugates / Q000737:chemistry* / Q000627:therapeutic use*; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D058726:Nanoconjugates