title: Synthesis and anti-mycobacterial activity of 2-chloronicotinaldehydes based novel 1H-1,2,3-triazolylbenzohydrazides.
abstract: 1H-1,2,3-Triazolylbenzohydrazides (6a-h and 11a-l) were synthesized from 2-chloronicotinaldehydes and evaluated for anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv strain (ATCC-27294). Seven compounds 6b, 6e,f, 11d, 11h, 11j and 11l displayed potent anti-mycobacterial activity (MIC 2.8-6.2 μM). Potent anti-mycobacterial compounds were chosen for cytotoxicity studies by MTT protein assay against normal cell lines (PBMC and Raw 264.7) and shown low cytotoxicity. This is the first Letter assigning anti-mycobacterial activity, cytotoxicity and structure activity relationship for 1H-1,2,3-triazolylbenzohydrazides.
authors.affiliation: Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Pathi
authors.initials: P
authors.lastname: Suman
authors.affiliation: Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Cherupally
authors.initials: C
authors.lastname: Dayakar
authors.affiliation: Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Kommera
authors.initials: K
authors.lastname: Rajkumar
authors.affiliation: Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Bomma
authors.initials: B
authors.lastname: Yashwanth
authors.affiliation: Birla Institute of Technology & Science-Pilani, Hyderabad 500 078, India.
authors.forename: Perumal
authors.initials: P
authors.lastname: Yogeeswari
authors.affiliation: Birla Institute of Technology & Science-Pilani, Hyderabad 500 078, India.
authors.forename: Dharmarajan
authors.initials: D
authors.lastname: Sriram
authors.affiliation: Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Janapala Venkateswara
authors.initials: JV
authors.lastname: Rao
authors.affiliation: Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. Electronic address: chinaraju@iict.res.in.
authors.forename: Bhimapaka China
authors.initials: BC
authors.lastname: Raju
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D006834:Hydrazines / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
chemical_list: D000447:Aldehydes; D000995:Antitubercular Agents; D006834:Hydrazines
keywords: 1H-1,2,3-Triazolylbenzohydrazides; 2-Chloronicotinaldehydes; Anti-mycobacterial activity; Click chemistry; Cytotoxicity