title: Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory.
abstract: The relationship between biological scaffold interconnectivity and cell migration is an important but poorly understood factor in tissue regeneration. Here a scale-independent technique for characterization of collagen scaffold interconnectivity is presented, using a combination of X-ray microcomputed tomography and percolation theory. Confocal microscopy of connective tissue cells reveals this technique as highly relevant for determining the extent of cell invasion.
authors.affiliation: Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Ashworth
authors.affiliation: Geistlich Pharma AG, Core Technologies, Bahnhofstrasse 40, CH-6110, Wolhusen, Switzerland.
authors.forename: Marco
authors.initials: M
authors.lastname: Mehr
authors.affiliation: Geistlich Pharma AG, Core Technologies, Bahnhofstrasse 40, CH-6110, Wolhusen, Switzerland.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Buxton
authors.affiliation: Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK.
authors.forename: Serena M
authors.initials: SM
authors.lastname: Best
authors.affiliation: Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK.
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Cameron
mesh_terms: D002465:Cell Movement; D002478:Cells, Cultured; D003094:Collagen / Q000737:chemistry*; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D054457:Tissue Scaffolds / Q000737:chemistry*; D055114:X-Ray Microtomography
chemical_list: D003094:Collagen
keywords: cell invasion; collagen scaffolds; interconnectivity; percolation; scaffold characterization