title: Analysis of the origin and importance of acetone and isopropanol levels in the blood of the deceased for medico-legal testimony.
abstract: The aim of the study was to analyze the incidence of acetone and isopropanol in the blood of the deceased, and to assess cases in which the compounds have been detected with a focus on their origin and usefulness for medico-legal testimony.
  
  
  METHODS
  The study material consisted of results of tests detecting ethyl alcohol and reports of autopsies performed at the Department of Forensic Medicine, Medical University of Warsaw, from January 2008 to April 2009 - a total of 2,475 cases. The test group proper (group B) comprised only those cases in which acetone was detected in blood, either with or without isopropanol [n = 202 (8.2%)]. The blood levels of isopropanol varied depending on the cause of death. The need for differentiating the origin of isopropanol in the case of its presence in the blood of the deceased was pointed out.
  
  
  RESULTS
  The results of the present study show that the differentiation should be based on the isopropanol and acetone concentration ratio, as isopropanol concentration alone is not sufficient for preparing expert opinions. Even high concentrations of isopropanol, when accompanied by even higher concentrations of acetone, imply that isopropanol could have been formed as a result of acetone transformations. Isopropanol concentrations exceeding acetone levels strongly point to the exogenous origin of isopropanol, particularly when high levels of ethanol are concurrently detected.
authors.affiliation: Aleksandra Borowska-Solonynko, Forensic Medicine Department, Medical University of Warsaw, Oczki 1, 02-007 Warsaw, Poland, tel. +48 22 628 89 75, e-mail: brunka-80@o2.pl.
authors.forename: A
authors.initials: A
authors.lastname: Borowska-Solonynko
authors.forename: A
authors.initials: A
authors.lastname: Siwińska-Ziółkowska
authors.forename: M
authors.initials: M
authors.lastname: Piotrkowicz
authors.forename: M
authors.initials: M
authors.lastname: Wysmołek
authors.forename: M
authors.initials: M
authors.lastname: Demkow
mesh_terms: D019840:2-Propanol / Q000032:analysis* / Q000378:metabolism; D000096:Acetone / Q000032:analysis* / Q000378:metabolism; D000328:Adult; D000368:Aged; D000435:Alcoholic Intoxication / Q000378:metabolism*; D003334:Coroners and Medical Examiners; D000431:Ethanol / Q000032:analysis; D005260:Female; D053593:Forensic Toxicology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D011180:Postmortem Changes; D012997:Solvents / Q000032:analysis* / Q000378:metabolism; D013048:Specimen Handling; D055815:Young Adult
chemical_list: D012997:Solvents; D000096:Acetone; D000431:Ethanol; D019840:2-Propanol