title: Modeling of an optimized electrostimulative hip revision system under consideration of uncertainty in the conductivity of bone tissue.
abstract: Since several years, the number of total hip arthroplasty revision surgeries is substantially growing. One of the main reasons for this procedure to become necessary is the loosening or damage of the prothesis, which is facilitated by bone necrosis at the implant-bone interface. Electrostimulation is one promising technique, which can accelerate the growth of bone cells and, therefore, enhance the anchorage of the implant to the bone. We present computational models of an electrostimulative total hip revision system to enhance bone regeneration. In this study, the influence of uncertainty in the conductivity of bone tissue on the electric field strength and the beneficial stimulation volume for an optimized electrode geometry and arrangement is investigated. The generalized polynomial chaos technique is used to quantify the uncertainty in the stimulation volumes with respect to the uncertain conductivity of cancellous bone, bone marrow, and bone substitute, which is used to fill defective areas. The results suggest that the overall beneficial stimulation areas are only slightly sensitive to the uncertainty in conductivity of bone tissue. However, in the proximity of tissue boundaries, larger uncertainties, especially in the transition between beneficial and understimulation areas, can be expected.
authors.forename: Christian
authors.initials: C
authors.lastname: Schmidt
authors.forename: Ulf
authors.initials: U
authors.lastname: Zimmermann
authors.forename: Ursula
authors.initials: U
authors.lastname: van Rienen
mesh_terms: D000818:Animals; D019644:Arthroplasty, Replacement, Hip; D004553:Electric Conductivity; D004558:Electric Stimulation; D005269:Femur / Q000502:physiology*; D020342:Finite Element Analysis; D006622:Hip Prosthesis; D006801:Humans; D008954:Models, Biological; D012086:Reoperation; D013552:Swine