title: Chromosomal aberration leads to recurrent pregnancy loss and partial trisomy of 5p12-15.3 in the offspring: report of a Syrian couple and review of the literature .
abstract: Here we describe a Syrian couple having recurrent pregnancy loss in the first trimester, fetal malformations, and/or neonatal death. The father had a balanced chromosomal translocation t(5;15), an sY125 microdeletion of locus b in the azoospermia factor (AZF) gene, and an MTHFR C677T homozygous polymorphism with normal phenotype. Interestingly, his healthy wife had another MTHFR A1298C homozygous polymorphism. The couple experienced two pregnancy losses and had two stillborn children with severe malformations due to partial trisomy of the short arm of chromosome 5. The couple does not have any living offspring after 10 years of marriage.
authors.forename: Walid
authors.initials: W
authors.lastname: Al-Achkar
authors.forename: Faten
authors.initials: F
authors.lastname: Moassass
authors.forename: Ayman
authors.initials: A
authors.lastname: Al-Ablog
authors.forename: Thomas
authors.initials: T
authors.lastname: Liehr
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Fan
authors.forename: Abdulsamad
authors.initials: A
authors.lastname: Wafa
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D053713:Azoospermia / Q000235:genetics; D002869:Chromosome Aberrations; D002895:Chromosomes, Human, Pair 5; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006720:Homozygote; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D014178:Translocation, Genetic; D014314:Trisomy
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)