title: State of the Art: Newer biomarkers in heart failure.
abstract: Since natriuretic peptides were successfully integrated into the clinical practice of heart failure (HF), the possibility of using new biomarkers to advance the management of affected patients has been explored. While a huge number of candidate HF biomarkers have been described recently, very few have made the difficult translation from initial promise to clinical application. These markers mirror the complex pathophysiology of heart failure at various levels: cell loss (troponin), fibrosis (ST2 and galectin-3), infection (procalcitonin), and renal disease (several renal markers). In this review, we examine the best emerging candidates for clinical assessment and management of patients with HF.
authors.affiliation: University of Groningen, University Medical Center, Department of Cardiology, Groningen, The Netherlands.
authors.forename: Rudolf A
authors.initials: RA
authors.lastname: de Boer
authors.affiliation: Division of Cardiology, University of California at San Diego, La Jolla, CA, USA.
authors.forename: Lori B
authors.initials: LB
authors.lastname: Daniels
authors.affiliation: Division of Cardiology, University of California at San Diego, La Jolla, CA, USA.|Division of Cardiology, Veterans Affairs San Diego Medical Center, La Jolla, CA, USA.
authors.forename: Alan S
authors.initials: AS
authors.lastname: Maisel
authors.affiliation: Cardiology Division of the Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Januzzi
mesh_terms: D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D037502:Galectin 3 / Q000097:blood*; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011498:Protein Precursors / Q000097:blood*; D011956:Receptors, Cell Surface / Q000097:blood*; D014336:Troponin / Q000097:blood*
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D037502:Galectin 3; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011498:Protein Precursors; D011956:Receptors, Cell Surface; D014336:Troponin; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide
keywords: Biomarkers; Diagnosis; Heart failure; Monitoring; Prognosis