title: Graft function 1 year after pregnancy in an islet-transplanted patient.
abstract: Pancreatic islet transplantation is a treatment option for patients with type 1 diabetes (T1D), but pregnancy has generally not been advised for women after receiving an islet allograft. We hereby describe what is to our knowledge the first successful pregnancy and persistent graft function in a woman 4 years after her initial islet transplantation. A 37-year-old woman with brittle type 1 diabetes was transplanted with two separate islet graft infusions, eventually becoming insulin independent. Ten months after her second transplantation, her immunosuppression was switched from tacrolimus and sirolimus to tacrolimus, azathioprine, and prednisolone, due to her wish to become pregnant. She became pregnant one year later, and after 38 weeks of uncomplicated pregnancy, she gave birth to a healthy child by C-section. The current report suggests that pregnancy and childbirth can be accomplished after islet transplantation without loss of islet graft function.
authors.affiliation: Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway.|Institute for Surgical Research, Oslo University Hospital, Oslo, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Simen W
authors.initials: SW
authors.lastname: Schive
authors.affiliation: Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway.|Institute for Surgical Research, Oslo University Hospital, Oslo, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Hanne
authors.initials: H
authors.lastname: Scholz
authors.affiliation: Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway.|Institute for Surgical Research, Oslo University Hospital, Oslo, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Afaf
authors.initials: A
authors.lastname: Sahraoui
authors.affiliation: Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway.|Institute for Surgical Research, Oslo University Hospital, Oslo, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Kristine
authors.initials: K
authors.lastname: Kloster-Jensen
authors.affiliation: Department of Radiology, Oslo University Hospital, Oslo, Norway.
authors.forename: Geir
authors.initials: G
authors.lastname: Hafsahl
authors.affiliation: Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
authors.forename: Olle
authors.initials: O
authors.lastname: Korsgren
authors.affiliation: Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway.|Institute for Surgical Research, Oslo University Hospital, Oslo, Norway.|Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Aksel
authors.initials: A
authors.lastname: Foss
authors.affiliation: Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway.|Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
authors.forename: Trond G
authors.initials: TG
authors.lastname: Jenssen
mesh_terms: D000328:Adult; D002096:C-Peptide / Q000097:blood; D002585:Cesarean Section; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D057915:Drug Substitution; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007231:Infant, Newborn; D007515:Islets of Langerhans / Q000502:physiology*; D016381:Islets of Langerhans Transplantation; D011247:Pregnancy; D011248:Pregnancy Complications; D012086:Reoperation; D019737:Transplants / Q000502:physiology
chemical_list: D002096:C-Peptide; D007166:Immunosuppressive Agents
keywords: glucocorticoids; islet transplantation; pregnancy; type 1 diabetes