title: [The association between angiogenin gene variations and familial amyotrophic lateral sclerosis in Chinese Han patients].
abstract: OBJECTIVE
  To investigate effect of genetic variants in angiogenin (ANG) on the susceptibility of familial amyotrophic lateral sclerosis (FALS) in Han Chinese.
  
  
  METHODS
  Thirty-one FALS families from 2009 to 2012 were collected and ANG gene was screened in the probands using PCR and direct sequencing.
  
  
  RESULTS
  All 31 ALS families were autosomal dominant inheritance. No mutations and single nucleotide polymorphism were detectable in ANG gene in the 31 probands.
  
  
  CONCLUSIONS
  Our study suggests that ANG gene variations may be rare in Chinese Han FALS.
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Huagang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Yingshuang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China. Email: dsfan@sina.com.
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Fan
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000208:ethnology* / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002681:China; D006801:Humans; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D012259:Ribonuclease, Pancreatic / Q000235:genetics*
chemical_list: C046366:angiogenin; D012259:Ribonuclease, Pancreatic