title: The role of orexin in post-stroke inflammation, cognitive decline, and depression.
abstract: Ischemic stroke results in diverse pathophysiologies, including cerebral inflammation, neuronal loss, cognitive dysfunction, and depression. Studies aimed at identifying therapeutic solutions to alleviate these outcomes are important due to the increase in the number of stroke patients annually. Recently, many studies have reported that orexin, commonly known as a neuropeptide regulator of sleep/wakefulness and appetite, is associated with neuronal cell apoptosis, memory function, and depressive symptoms. Here, we briefly summarize recent studies regarding the role and future perspectives of orexin in post-ischemic stroke. This review advances our understanding of the role of orexin in post-stroke pathologies, focusing on its possible function as a therapeutic regulator in the post-ischemic brain. Ultimately, we suggest the clinical potential of orexin to regulate post-stroke pathologies.
authors.affiliation: Department of Anatomy, Yonsei University College of Medicine, Seoul, 120-752, South Korea. sjh1008@yuhs.ac.
authors.forename: Juhyun
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Pharmacology, Yonsei University College of Medicine, 120-752, Seoul, South Korea. KIMEOSU@yuhs.ac.
authors.forename: Eosu
authors.initials: E
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, Yonsei University College of Medicine, 120-752, Seoul, South Korea. KIMHOON@yuhs.ac.
authors.forename: Chul-Hoon
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Department of Diagnostic Radiology, Yonsei University College of Medicine, 120-752, Seoul, South Korea. HOTSONG@yuhs.ac.
authors.forename: Ho-Taek
authors.initials: HT
authors.lastname: Song
authors.affiliation: Department of Anatomy, Yonsei University College of Medicine, Seoul, 120-752, South Korea. jelee@yuhs.ac.|BK21 Plus Project for Medical Sciences, and Brain Research Institute, Yonsei University, College of Medicine, Seoul, 120-752, South Korea. jelee@yuhs.ac.
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Lee
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism; D003863:Depression / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism; D008954:Models, Biological; D000068797:Orexins / Q000378:metabolism*; D020521:Stroke / Q000150:complications* / Q000378:metabolism
chemical_list: D000068797:Orexins