title: Aflatoxin levels in chronic hepatitis B patients with cirrhosis or hepatocellular carcinoma in Balıkesir, Turkey.
abstract: Aflatoxins, the secondary metabolites produced by species of naturally occurring Aspergilli, are commonly found in food such as cereals, dried fruits and juice, wine, beer and spices. They are hepatotoxic and are well known human carcinogens based on evidence from human studies. Aflatoxins are an environmental risk factor for the development of hepatocellular carcinoma (HCC). Chronic hepatitis B-infected patients are at increased risk of cirrhosis, hepatic failure and liver cancer. This study was designed to determine the serum aflatoxin B1 (AFB1 ), aflatoxin B2 (AFB2 ), aflatoxin G1 (AFG1 ) and aflatoxin G2 (AFG2 ) concentrations using high-pressure liquid chromatography (HPLC) in hepatitis B-infected patients with or without cirrhosis and liver cancer, alongside healthy controls in Balıkesir, Turkey. The mean AFB1 and total AF levels in patients without liver cancer and cirrhosis were significantly higher than healthy controls. The mean AFB1 and total AF levels in patients with chronic hepatitis B and HCC were significantly higher than infected patients with or without cirrhosis. These results suggest that patients with chronic hepatitis B who are exposed to AFs are at increased risk for developing HCC, which might be prevented by reducing consumption of contaminated foods.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Istanbul Hospital of Başkent University, Istanbul, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Aydın
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Aydın
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Bacanlı
authors.affiliation: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Başaran
mesh_terms: D000328:Adult; D000348:Aflatoxins / Q000097:blood*; D000368:Aged; D002273:Carcinogens / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000150:complications*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D064368:Healthy Volunteers; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014421:Turkey
chemical_list: D000348:Aflatoxins; D002273:Carcinogens
keywords: Turkey; aflatoxins; chronic hepatitis B; cirrhosis; hepatocellular carcinoma