title: Physicochemical properties and responses in microcirculation of native tapioca starch-based plasma expander.
abstract: Plasma expanders (PEs) such as hydroxyethyl strach are widely used for volume replacement. The plantation and production of tapioca in Thailand is abundant which may provide a new source for PEs starch with novel properties. This work investigated the properties and circulatory effects of native tapioca starch-based PE (TPE). Various formulations of mixture between native tapioca starch and 0.9% sodium chloride solution were prepared and characterized in order to obtain the proper physicochemical and rheological properties. About 1% concentration by weight per volume of TPE was compared with 6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride (HES130/0.4) using an acute hemodilution by 40% of blood volume in an animal protocol. TPE had higher turbidity and viscosity but lower colloid osmotic pressure compared with HES 130/0.4. The in vivo study demonstrated that Golden Syrian hamsters hemodiluted with TPE maintained a mean arterial blood pressure and no significant difference compared to HES 130/0.4. The arterial vasodilation and functional capillary density in the animals hemodiluted with TPE had higher values than in the animals hemodiluted with HES 130/0.4. Although the in vivo study reported positive results using this native tapioca starch-based PE, the product needs work to improve some of its physiochemical properties.
authors.affiliation: Institute of Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.|Biological Materials for Medicine Research Unit, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
authors.forename: Surapong
authors.initials: S
authors.lastname: Chatpun
authors.affiliation: Institute of Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.|Biological Materials for Medicine Research Unit, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
authors.forename: Jirut
authors.initials: J
authors.lastname: Meesane
authors.affiliation: Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
authors.forename: Pairaya
authors.initials: P
authors.lastname: Rujirojindakul
mesh_terms: D000818:Animals; D006224:Cricetinae; D006438:Hemodilution; D018056:Hemorheology; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology; D002365:Manihot / Q000737:chemistry*; D008647:Mesocricetus; D008833:Microcirculation / Q000187:drug effects*; D010952:Plasma Substitutes / Q000737:chemistry / Q000494:pharmacology; D013213:Starch / Q000737:chemistry / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
chemical_list: C485123:HES 130-0.4; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D013213:Starch
keywords: microcirculation; physicochemical properties; plasma expander; tapioca starch