title: Association of plasma and synovial fluid periostin with radiographic knee osteoarthritis: Cross-sectional study.
abstract: OBJECTIVE
  To investigate plasma and synovial fluid (SF) periostin of knee osteoarthritis (OA) patients and to determine the relationship between periostin levels and the radiographic severity.
  
  
  METHODS
  A total of 110 subjects (90 knee OA patients and 20 healthy controls) were enrolled in this study. Plasma and SF periostin were examined using an enzyme-linked immunosorbent assay. OA grading was performed using the Kellgren-Lawrence classification.
  
  
  RESULTS
  Although plasma periostin was greater in OA patients than in controls, the difference was not significant. Additionally, SF periostin was significantly higher with respect to paired plasma (P<0.001). Moreover, plasma and SF periostin demonstrated significantly positive correlation with the radiographic severity of knee OA (r=0.537, P<0.001 and r=0.427, P<0.001, respectively). Subsequent analysis revealed that there was a positive correlation between plasma and SF periostin (r=0.368, P<0.001).
  
  
  CONCLUSIONS
  Plasma and SF periostin levels were positively correlated with the radiographic severity of knee OA.
authors.affiliation: Department of Biochemistry and Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873, Rama IV road, Patumwan, 10330 Bangkok, Thailand; Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 10330 Bangkok, Thailand. Electronic address: Sittisak.H@chula.ac.th.
authors.forename: Sittisak
authors.initials: S
authors.lastname: Honsawek
authors.affiliation: Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 10330 Bangkok, Thailand.
authors.forename: Vajara
authors.initials: V
authors.lastname: Wilairatana
authors.affiliation: Department of Biochemistry and Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873, Rama IV road, Patumwan, 10330 Bangkok, Thailand.
authors.forename: Wanvisa
authors.initials: W
authors.lastname: Udomsinprasert
authors.affiliation: Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 10330 Bangkok, Thailand.
authors.forename: Peerasit
authors.initials: P
authors.lastname: Sinlapavilawan
authors.affiliation: Department of Biochemistry and Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873, Rama IV road, Patumwan, 10330 Bangkok, Thailand.
authors.forename: Napaphat
authors.initials: N
authors.lastname: Jirathanathornnukul
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging* / Q000378:metabolism; D011859:Radiography; D012720:Severity of Illness Index; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C512835:POSTN protein, human
keywords: Osteoarthritis; Periostin; Plasma; Radiographic severity; Synovial fluid