title: Nanosilver based anionic linear globular dendrimer with a special significant antiretroviral activity.
abstract: HIV is commonly caused to a very complicated disease which has not any recognized vaccine, so designing and development of novel antiretroviral agents with specific application of nanomedicine is a globally interested research subject worldwide. In the current study, a novel structure of silver complexes with anionic linear globular dendrimer was synthesized, characterized and then assessed against HIV replication pathway in vitro as well. The results showed a very good yield of synthesis (up to 70%) for the nano-complex as well as a very potent significant (P < 0.05) antiretroviral activity with non-severe toxic effects in comparison with the Nevirapine as standard drug in positive control group. According to the present data, silver anionic linear globular dendrimers complex may have a promising future to inhibit replication of HIV viruse in clinical practice.
authors.affiliation: Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehdi Shafiee
authors.initials: MS
authors.lastname: Ardestani
authors.forename: Alireza Salehi
authors.initials: AS
authors.lastname: Fordoei
authors.forename: Asghar
authors.initials: A
authors.lastname: Abdoli
authors.forename: Reza
authors.initials: R
authors.lastname: Ahangari Cohan
authors.forename: Golnaz
authors.initials: G
authors.lastname: Bahramali
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Sadat
authors.forename: Seyed Davar
authors.initials: SD
authors.lastname: Siadat
authors.forename: Hamid
authors.initials: H
authors.lastname: Moloudian
authors.forename: Nasser
authors.initials: N
authors.lastname: Nassiri Koopaei
authors.forename: Azam
authors.initials: A
authors.lastname: Bolhasani
authors.forename: Pooneh
authors.initials: P
authors.lastname: Rahimi
authors.forename: Soheila
authors.initials: S
authors.lastname: Hekmat
authors.forename: Mehdi
authors.initials: M
authors.lastname: Davari
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Aghasadeghi
mesh_terms: D000838:Anions; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D050091:Dendrimers / Q000737:chemistry / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry*; D010316:Particle Size; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects / Q000502:physiology*
chemical_list: D000838:Anions; D000998:Antiviral Agents; D050091:Dendrimers; D012834:Silver