title: Epidemiological profile of Dupuytren's disease in Taiwan (Ethnic Chinese): a nationwide population-based study.
abstract: BACKGROUND
  The epidemiologic profile of ethnic Chinese patients with Dupuytren's disease is unknown. We therefore investigated the epidemiology of Dupuytren's disease using Taiwan's National Health Insurance Research Database.
  
  
  METHODS
  Patients who filed claims for treatment for Dupuytren's disease between January 2000 and December 2011 were identified in the database. Age- and gender-specific incidences were estimated by dividing the incidence number by population data.
  
  
  RESULTS
  We identified 1,078 patients with Dupuytren's disease (681 men, 397 women; male/female ratio: 1:1.72). The annual incidence rate ranged from 0.39-0.63/10(5) for men and 0.14-0.44/10(5) for women. A trend analysis revealed a rising trend in the annual incidence from 2001 to 2011 (p = 0.0199). The prevalence rate increased steadily from 0.46/10(5) in 2000 to 4.52/10(5) in 2011 (p = 0.0186). The mean age at onset was significantly higher in men than in women (60.7 ± 18.4 vs. 53.7 ± 15.5 years). Peak age at onset for men was 70-79 (28.1%) and for women was 50-59 (33.5%). Men > 60 years old had higher incidence rates than did women (incidence rate ratios: 2.0, 4.5, and 6.6 for those 60-69, 70-79, and ≥ 80, respectively). Hypertension (29.6%), diabetes mellitus (21.9%), hyperlipidemia (14.8%), ischemic heart disease (10.5%), and chronic obstructive pulmonary disease (8.0%) were the most common comorbidities.
  
  
  CONCLUSIONS
  The incidence and prevalence of Dupuytren's disease and the male/female ratio were significantly lower in ethnic Chinese than in Western ethnic groups. Moreover, the age at onset was significantly lower in ethnic Chinese women. However, the incidences of three comorbidities (hypertension, diabetes mellitus, and hyperlipidemia) were similar to those in other ethnicities.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, Chi-Mei Medical Center, Yong-Kang, Tainan, Taiwan. frankyeh1977@gmail.com.
authors.forename: Chin-Choon
authors.initials: CC
authors.lastname: Yeh
authors.affiliation: Division of Plastic Surgery, Department of Surgery, Chi-Mei Medical Center, Yong-Kang, Tainan, Taiwan. d881101@mail.chimei.org.tw.
authors.forename: Kuo-Feng
authors.initials: KF
authors.lastname: Huang
authors.affiliation: Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan. ho.c.hank@gmail.com.|Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan. ho.c.hank@gmail.com.
authors.forename: Chung-Han
authors.initials: CH
authors.lastname: Ho
authors.affiliation: Department of Anesthesiology, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang District, Tainan, 71004, Taiwan. chengt890219@gmail.com.
authors.forename: Kuan-Ting
authors.initials: KT
authors.lastname: Chen
authors.affiliation: Division of Plastic Surgery, Department of Surgery, Chi-Mei Medical Center, Yong-Kang, Tainan, Taiwan. orangeliu@gmail.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan. 400002@mail.chimei.org.tw.|Department of Anesthesiology, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang District, Tainan, 71004, Taiwan. 400002@mail.chimei.org.tw.
authors.forename: Jhi-Joung
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang District, Tainan, 71004, Taiwan. chinchen.chu@gmail.com.|Department of Recreation and Health-Care Management, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan. chinchen.chu@gmail.com.
authors.forename: Chin-Chen
authors.initials: CC
authors.lastname: Chu
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D015897:Comorbidity; D004387:Dupuytren Contracture / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology; D014505:Urban Population / Q000706:statistics & numerical data