title: Molecular heterogeneity characterizes glioblastoma with lipoblast/adipocyte-like cytology.
abstract: Glioblastoma, the most common primary brain tumor in adults, may rarely show among unusual histological patterns lipoblast/adipocyte-like features. The genetic features of such cases are not yet well characterized, and molecular data are available for only few cases. In order to further expand our knowledge about their molecular profile, we analyzed four cases of glioblastoma with adipocyte-like features. Multiplex ligation-dependent probe amplification (MLPA) revealed loss of PTEN and MDM2 amplification in two cases while another case was characterized by CDKN2A deletion. Conversely, we did not find any evidence of EGFR amplification, BRAF (V600E) or IDH1/2 mutations. Our results, along with data published in previous studies, showed that glioblastoma with lipoblast/adipocyte-like cytology present a heterogeneous genetic background and therefore seem to represent more a rare phenotypic variant than a specific tumor subtype.
authors.affiliation: Institute of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Straße 25, 53127, Bonn, Germany, mgessimd@yahoo.com.
authors.forename: Marco
authors.initials: M
authors.lastname: Gessi
authors.forename: Gerrit H
authors.initials: GH
authors.lastname: Gielen
authors.forename: Dorota
authors.initials: D
authors.lastname: Denkhaus
authors.forename: Manila
authors.initials: M
authors.lastname: Antonelli
authors.forename: Felice
authors.initials: F
authors.lastname: Giangaspero
authors.forename: Anja
authors.initials: A
authors.lastname: Zur Mühlen
authors.forename: Anna Sophia
authors.initials: AS
authors.lastname: Japp
authors.forename: Torsten
authors.initials: T
authors.lastname: Pietsch
mesh_terms: D017667:Adipocytes / Q000473:pathology*; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005909:Glioblastoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008869:Microtubule-Associated Proteins / Q000032:analysis; D051059:PTEN Phosphohydrolase / Q000235:genetics; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics
chemical_list: D005904:Glial Fibrillary Acidic Protein; C489788:MAP2 protein, human; D008869:Microtubule-Associated Proteins; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human