title: Epidemiology of vancomycin-resistant enterococci in Canadian hospitals (CANWARD study, 2007 to 2013).
abstract: Of 1,927 Enterococcus species isolates collected across Canada from 2007 to 2013, 80 (4.2%) were identified as vancomycin-resistant enterococci (VRE). VRE infections during this time tripled in Canadian hospitals, from 1.8% to 6.0% (P = 0.03). All VRE were Enterococcus faecium, with 90% possessing vanA. The prevalence of vanB decreased from 37.5% in 2007 to 0% in 2013 (P < 0.05). The VRE were multidrug resistant, but 70.6%, 86.3%, and 100% were susceptible to doxycycline, linezolid, and daptomycin, respectively.
authors.affiliation: Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada psimner1@jhmi.edu.
authors.forename: P J
authors.initials: PJ
authors.lastname: Simner
authors.affiliation: Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Adam
authors.affiliation: University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Baxter
authors.affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
authors.forename: M
authors.initials: M
authors.lastname: McCracken
authors.affiliation: University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Golding
authors.affiliation: Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada.
authors.forename: J A
authors.initials: JA
authors.lastname: Karlowsky
authors.affiliation: Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Nichol
authors.affiliation: Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Lagacé-Wiens
authors.affiliation: Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada.
authors.forename: M W
authors.initials: MW
authors.lastname: Gilmour
authors.affiliation: Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada.
authors.forename: D J
authors.initials: DJ
authors.lastname: Hoban
authors.affiliation: Diagnostic Services Manitoba, Winnipeg, Manitoba, Canada University of Manitoba, Department of Medical Microbiology and Infectious Diseases, Winnipeg, Manitoba, Canada.
authors.forename: G G
authors.initials: GG
authors.lastname: Zhanel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D002170:Canada / Q000453:epidemiology; D019729:Carbon-Oxygen Ligases / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D016983:Enterococcus / Q000187:drug effects*; D016984:Enterococcus faecium / Q000187:drug effects; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology*; D006761:Hospitals; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015995:Prevalence; D062486:Public Health Surveillance; D014640:Vancomycin / Q000494:pharmacology; D020713:Vancomycin Resistance; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C071437:VanA ligase, Bacteria; C079913:VanB protein, Enterococcus; D014640:Vancomycin; D019729:Carbon-Oxygen Ligases