title: Control of lymphocyte homeostasis and effector function by the aryl hydrocarbon receptor.
abstract: The adaptive immune system, composed of lymphocytes, recognizes diversified antigens and generates immunological memory. According to the canonical model, it is the innate immune system that captures pathogens and senses environment to activate adaptive lymphocytes through antigen presentation, costimulatory signals and cytokine milieu. Emerging evidence indicates that environmental cues can be directly conveyed to lymphocytes by the aryl hydrocarbon receptor (AhR). AhR is a ligand-activated transcription factor that widely expresses in many immune cell lineages and recognizes a broad range of ligands including endogenous and dietary metabolites, microbial derivatives and xenobiotics. This review will focus on the regulatory role of AhR in not only adaptive but also innate lymphocytes including recently discovered innate lymphoid cells.
authors.affiliation: Molecular Immunomodulation Laboratory, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, Shandong 250014, China.
authors.forename: Yunbo
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Molecular Immunomodulation Laboratory, School of Biomedical Sciences, Monash University, Victoria 3800, Australia; Laboratory of Immunology for Environment and Health, Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan, Shandong 250014, China. Electronic address: Di.Yu@monash.edu.
authors.forename: Di
authors.initials: D
authors.lastname: Yu
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D006706:Homeostasis; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000276:immunology*; D018336:Receptors, Aryl Hydrocarbon / Q000276:immunology*
chemical_list: D018336:Receptors, Aryl Hydrocarbon
keywords: Adaptive lymphocyte; AhR; Innate lymphocyte; Ligand