title: Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.
abstract: Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 in the polyploidization of decidual cells in mice. E2F8 is highly expressed in decidual cells and regulated by progesterone through HB-EGF/EGFR/ERK/STAT3 signaling pathway. E2F8 transcriptionally suppresses CDK1, thus triggering the polyploidization of decidual cells. E2F8-mediated polyploidization is a response to stresses which are accompanied by decidualization. Interestingly, polyploidization is not detected during human decidualization with the down-regulation of E2F8, indicating differential expression of E2F8 may lead to the difference of decidual cell polyploidization between mice and humans.
authors.affiliation: a College of Veterinary Medicine; South China Agricultural University ; Guangzhou , China.
authors.forename: Qian-Rong
authors.initials: QR
authors.lastname: Qi
authors.forename: Xu-Yu
authors.initials: XY
authors.lastname: Zhao
authors.forename: Ru-Juan
authors.initials: RJ
authors.lastname: Zuo
authors.forename: Tong-Song
authors.initials: TS
authors.lastname: Wang
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Gu
authors.forename: Ji-Long
authors.initials: JL
authors.lastname: Liu
authors.forename: Zeng-Ming
authors.initials: ZM
authors.lastname: Yang
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D002460:Cell Line; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004249:DNA Damage; D003656:Decidua / Q000502:physiology*; D005260:Female; D005434:Flow Cytometry; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D051379:Mice; D008856:Microscopy, Fluorescence; D010053:Ovary / Q000378:metabolism; D011123:Polyploidy; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000378:metabolism; D012097:Repressor Proteins / Q000502:physiology*; D015398:Signal Transduction; D013482:Superoxide Dismutase / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
chemical_list: C504723:E2F8 protein, human; C504722:E2F8 protein, mouse; D012097:Repressor Proteins; D011374:Progesterone; D013482:Superoxide Dismutase; D016203:CDC2 Protein Kinase; C528899:CDK1 protein, human; D018844:Cyclin-Dependent Kinases
keywords: CDK1, cyclin-dependent kinase 1; CPT, Camptothecin; E2, estrogen; E2F8; MKC, megakaryocyte; P4, progesterone; PA, Purvalanol A; TGC, Trophoblast giant cell.; decidualization; polyploidization