title: Topiramate in Alcohol Use Disorders: Review and Update.
abstract: To date, a limited number of pharmacological agents exist to treat alcohol use disorders (AUDs), and there is growing interest in new therapeutic tools. In this framework, topiramate may represent a useful treatment option, although its use is not yet approved for AUDs. The main focus of this review is to discuss all the existing data supporting the use of topiramate in AUDs, with an emphasis on the most recent and relevant clinical implications. In addition, the profile of the alcoholic patient who may benefit more from the use of topiramate is outlined. In this regard, the authors conducted a PubMed search of clinical human studies published in English using the following key words: topiramate alcohol dependence, topiramate alcohol withdrawal and topiramate alcoholism. The evidence suggests that topiramate could be an effective treatment option for the management of AUDs, while there are limited results for its use to treat alcohol withdrawal syndrome. In particular, topiramate shows a greater beneficial effect in subjects with a typology of craving characterised by drinking obsessions and automaticity of drinking. Topiramate, within the dosage range of 75-300 mg/day, could be considered as a first-line treatment option for the management of AUDs. Its use appears to be safe and well-tolerated, especially in light of very recent findings.
authors.affiliation: Department of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry, Catholic University Medical School of Rome, Rome, Italy. ricguglielmo@gmail.com.|, Via Padre Pio, 16, 81042, Calvi Risorta, Italy. ricguglielmo@gmail.com.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Guglielmo
authors.affiliation: Department of Neuroscience and Imaging, University "G. D'Annunzio", Chieti, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinotti
authors.affiliation: Department of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry, Catholic University Medical School of Rome, Rome, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Quatrale
authors.affiliation: Department of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry, Catholic University Medical School of Rome, Rome, Italy.|Department of Human Science, Lumsa University of Rome, Rome, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Ioime
authors.affiliation: Department of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry, Catholic University Medical School of Rome, Rome, Italy.
authors.forename: Irket
authors.initials: I
authors.lastname: Kadilli
authors.affiliation: Department of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry, Catholic University Medical School of Rome, Rome, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Di Nicola
authors.affiliation: Department of Geriatrics, Neuroscience and Orthopedics, Institute of Psychiatry, Catholic University Medical School of Rome, Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Janiri
mesh_terms: D000427:Alcohol Deterrents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D019973:Alcohol-Related Disorders / Q000188:drug therapy*; D005632:Fructose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy; D000077236:Topiramate
chemical_list: D000427:Alcohol Deterrents; D000077236:Topiramate; D005632:Fructose