title: Nanoparticle coating on the silane-modified surface of magnesium for local drug delivery and controlled corrosion.
abstract: In this study, we proposed a potential method for the preparation of a magnesium-based medical device for local drug delivery and controlled corrosion. A magnesium surface was modified with 3-aminopropyltrimethoxy silane, and the resulting surface was then coated with drug-loaded nanoparticles made of poly (lactic-co-glycolic acid) via electrophoretic deposition. The drug-loaded nanoparticles (i.e., Tr_NP) exhibited a size of 250 ± 67 nm and a negative zeta potential of -20.9 ± 2.75 mV. The drug was released from the nanoparticles in a sustained manner for 21 days, and this did not change after their coating on the silane-modified magnesium. The silane-modified surface suppressed magnesium corrosion. When immersed in phosphate buffered saline at pH 7.4, the average rate of hydrogen gas generation was 0.41-0.45 ml/cm(2)/day, compared to 0.58-0.6 ml/cm(2)/day from a bare magnesium surface. This corrosion profile was not significantly changed after nanoparticle coating under the conditions employed in this work. The in vitro cell test revealed that the drug released from the coating was effective during the whole release period of 21 days, and both the silane-modified surface and carrier nanoparticles herein were not cytotoxic.
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, Republic of Korea.
authors.forename: Won Seok
authors.initials: WS
authors.lastname: Lee
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, Republic of Korea.
authors.forename: Min
authors.initials: M
authors.lastname: Park
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, Republic of Korea.
authors.forename: Myung Hun
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, Republic of Korea.
authors.forename: Chun Gwon
authors.initials: CG
authors.lastname: Park
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, Republic of Korea.
authors.forename: Beom Kang
authors.initials: BK
authors.lastname: Huh
authors.affiliation: Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul, Republic of Korea.
authors.forename: Hyun Kwang
authors.initials: HK
authors.lastname: Seok
authors.affiliation: Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, Republic of Korea Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, Republic of Korea Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Republic of Korea ybchoy@snu.ac.kr.
authors.forename: Young Bin
authors.initials: YB
authors.lastname: Choy
mesh_terms: D001826:Body Fluids / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis; D003343:Corrosion; D004058:Diffusion; D004343:Drug Implants / Q000008:administration & dosage* / Q000138:chemical synthesis*; D004595:Electroplating / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D019736:Prostheses and Implants; D012821:Silanes / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D053769:Nanocapsules; D012821:Silanes; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D008274:Magnesium
keywords: Coating; corrosion; drug delivery; electrophoretic deposition; magnesium; nanoparticles; silane