title: Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population.
abstract: BACKGROUND
  Overexpression of SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. In this study our primary objective is to explore the role of SLMAP gene polymorphisms in the susceptibility of type 2 diabetes (T2DM) with or without diabetic retinopathy (DR) in the Qatari population.
  
  
  METHODS
  A total of 342 Qatari subjects (non-diabetic controls and T2DM patients with or without DR) were genotyped for SLMAP gene polymorphisms (rs17058639 C > T; rs1043045 C > T and rs1057719 A > G) using Taqman SNP genotyping assay.
  
  
  RESULTS
  SLMAP rs17058639 C > T polymorphism was associated with the presence of DR among Qataris with T2DM. One-way ANOVA and multiple logistic regression analysis showed SLMAP SNP rs17058639 C > T as an independent risk factor for DR development. SLMAP rs17058639 C > T polymorphism also had a predictive role for the severity of DR. Haplotype Crs17058639Trs1043045Ars1057719 was associated with the increased risk for DR among Qataris with T2DM.
  
  
  CONCLUSIONS
  The data suggests the potential role of SLMAP SNPs as a risk factor for the susceptibility of DR among T2DM patients in the Qatari population.
authors.affiliation: Departments of Pharmacology, Weill Cornell Medical College-Qatar, Doha, Qatar. rohitupa@gmail.com.
authors.forename: Rohit
authors.initials: R
authors.lastname: Upadhyay
authors.affiliation: Departments of Genetic Medicine, Weill Cornell Medical College-Qatar, Doha, Qatar. amr2018@qatar-med.cornell.edu.
authors.forename: Amal
authors.initials: A
authors.lastname: Robay
authors.affiliation: Departments of Genetic Medicine, Weill Cornell Medical College-Qatar, Doha, Qatar. khf2002@qatar-med.cornell.edu.
authors.forename: Khalid
authors.initials: K
authors.lastname: Fakhro
authors.affiliation: Departments of Genetic Medicine, Weill Cornell Medical College-Qatar, Doha, Qatar. cha2022@qatar-med.cornell.edu.
authors.forename: Charbel
authors.initials: C
authors.lastname: Abi Khalil
authors.affiliation: Departments of Medicine, Hamad Medical Corporation, Doha, Qatar. maz2005@qatar-med.cornell.edu.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Zirie
authors.affiliation: Departments of Medicine, Hamad Medical Corporation, Doha, Qatar. aaj2004@qatar-med.cornell.edu.
authors.forename: Amin
authors.initials: A
authors.lastname: Jayyousi
authors.affiliation: Departments of Ophthalmology, Hamad Medical Corporation, Doha, Qatar. mahavr@hotmail.com.
authors.forename: Maha
authors.initials: M
authors.lastname: El-Shafei
authors.affiliation: Departments of Ophthalmology, Weill Cornell Medical College, New York, NY, USA. szk7001@med.cornell.edu.
authors.forename: Szilard
authors.initials: S
authors.lastname: Kiss
authors.affiliation: Departments of Ophthalmology, Weill Cornell Medical College, New York, NY, USA. djd2003@med.cornell.edu.
authors.forename: Donald J
authors.initials: DJ
authors.lastname: D'Amico
authors.affiliation: Departments of Genetic Medicine, Weill Cornell Medical College, New York, NY, USA. jas2038@med.cornell.edu.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Salit
authors.affiliation: Departments of Genetic Medicine, Weill Cornell Medical College, New York, NY, USA. mis2054@med.cornell.edu.
authors.forename: Michelle R
authors.initials: MR
authors.lastname: Staudt
authors.affiliation: Departments of Genetic Medicine, Weill Cornell Medical College, New York, NY, USA. sao9016@nyp.org.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: O'Beirne
authors.affiliation: Department of Cadre & Cardiology, The affiliated hospital of Hangzhou Normal University, Hangzhou, China. c5191@126.com.
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. btuana@uottawa.ca.
authors.forename: Balwant
authors.initials: B
authors.lastname: Tuana
authors.affiliation: Departments of Genetic Medicine, Weill Cornell Medical College, New York, NY, USA. rgcryst@med.cornell.edu.
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Crystal
authors.affiliation: Departments of Pharmacology, Weill Cornell Medical College-Qatar, Doha, Qatar. hod2005@qatar-med.cornell.edu.
authors.forename: Hong
authors.initials: H
authors.lastname: Ding
mesh_terms: D003710:Demography; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics*; D003930:Diabetic Retinopathy / Q000150:complications* / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011780:Qatar; D012044:Regression Analysis
chemical_list: D008565:Membrane Proteins; C109742:SLMAP protein, human