title: Therapeutic applications of spherical nucleic acids.
abstract: Spherical nucleic acids (SNAs) represent an emerging class of nanoparticle-based therapeutics. SNAs consist of densely functionalized and highly oriented oligonucleotides on the surface of a nanoparticle which can either be inorganic (such as gold or platinum) or hollow (such as liposomal or silica-based). The spherical architecture of the oligonucleotide shell confers unique advantages over traditional nucleic acid delivery methods, including entry into nearly all cells independent of transfection agents and resistance to nuclease degradation. Furthermore, SNAs can penetrate biological barriers, including the blood-brain and blood-tumor barriers as well as the epidermis, and have demonstrated efficacy in several murine disease models in the absence of significant adverse side effects. In this chapter, we will focus on the applications of SNAs in cancer therapy as well as discuss multimodal SNAs for drug delivery and imaging.
authors.affiliation: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
authors.forename: Stacey N
authors.initials: SN
authors.lastname: Barnaby
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Sita
authors.forename: Sarah Hurst
authors.initials: SH
authors.lastname: Petrosko
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Stegh
authors.forename: Chad A
authors.initials: CA
authors.lastname: Mirkin
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D061925:Immobilized Nucleic Acids / Q000627:therapeutic use*; D058726:Nanoconjugates / Q000627:therapeutic use*; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*
chemical_list: D061925:Immobilized Nucleic Acids; D058726:Nanoconjugates; D016376:Oligonucleotides, Antisense