title: Synthesis and biological evaluation of pseudolaric acid B derivatives as potential immunosuppressive agents.
abstract: Pseudolaric acid B (PB) derivatives with immunosuppressive activity were found by our group. In order to find potential immunosuppressive agents with high efficacy and low toxicity, a series of novel PB derivatives were synthesized and evaluated on their immunosuppressive activities. Most of the synthesized compounds were tested in vitro on murine T and B proliferation. In particular, compound 11 exhibited excellent inhibitory activity toward murine T cells (up to 19-fold enhancement compared to that of mycophenolatemofetil) and little cytotoxicity toward normal murine spleen cells. These experimental data demonstrated that some of these PB derivatives have great potential for future immunosuppressive studies.
authors.affiliation: a Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University , Tianjin 300070 , China.
authors.forename: Shou-Qiang
authors.initials: SQ
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Chuan
authors.initials: C
authors.lastname: Zhao
authors.forename: Qiang-Wen
authors.initials: QW
authors.lastname: Sun
authors.forename: Yi-Teng
authors.initials: YT
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Ai
authors.forename: Tan
authors.initials: T
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.forename: Huo
authors.initials: H
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D004224:Diterpenes; D007166:Immunosuppressive Agents; C058391:pseudolaric acid B
keywords: cytotoxicity; immunosuppressive activity; pseudolaric acid B derivatives