title: Oxime ligation on the surface of mesoporous silica nanoparticles.
abstract: A versatile surface-functionalization strategy applicable to mesoporous silica nanoparticles, which could potentially serve as drug delivery vehicles, is described that makes use of alkoxyamine tethers on the surface of the nanoparticles. A wide variety of carbonyl compounds can be attached readily to these tethers under the mild conditions of oxime ether formation, simply by incubating the chemically modified mesoporous silica nanoparticles with aldehydes or ketones in water.
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Ferris
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Paul R
authors.initials: PR
authors.lastname: McGonigal
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Leah S
authors.initials: LS
authors.lastname: Witus
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.|‡Department of Materials Science, National Institute of Technology, Wakayama College, Nada, Gobo, Wakayama 644-0023, Japan.
authors.forename: Takatoshi
authors.initials: T
authors.lastname: Kawaji
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Mohammed M
authors.initials: MM
authors.lastname: Algaradah
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Ahmed R
authors.initials: AR
authors.lastname: Alnajadah
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: Majed S
authors.initials: MS
authors.lastname: Nassar
authors.affiliation: †Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States.
authors.forename: J Fraser
authors.initials: JF
authors.lastname: Stoddart
mesh_terms: D016503:Drug Delivery Systems; D008026:Ligation; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D010091:Oximes; D012822:Silicon Dioxide