title: A sexually transmitted infection screening algorithm based on semiparametric regression models.
abstract: Sexually transmitted infections (STIs) with Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis are among the most common infectious diseases in the United States, disproportionately affecting young women. Because a significant portion of the infections present no symptoms, infection control relies primarily on disease screening. However, universal STI screening in a large population can be expensive. In this paper, we propose a semiparametric model-based screening algorithm. The model quantifies organism-specific infection risks in individual subjects and accounts for the within-subject interdependence of the infection outcomes of different organisms and the serial correlations among the repeated assessments of the same organism. Bivariate thin-plate regression spline surfaces are incorporated to depict the concurrent influences of age and sexual partners on infection acquisition. Model parameters are estimated by using a penalized likelihood method. For inference, we develop a likelihood-based resampling procedure to compare the bivariate effect surfaces across outcomes. Simulation studies are conducted to evaluate the model fitting performance. A screening algorithm is developed using data collected from an epidemiological study of young women at increased risk of STIs. We present evidence that the three organisms have distinct age and partner effect patterns; for C. trachomatis, the partner effect is more pronounced in younger adolescents. Predictive performance of the proposed screening algorithm is assessed through a receiver operating characteristic analysis. We show that the model-based screening algorithm has excellent accuracy in identifying individuals at increased risk, and thus can be used to assist STI screening in clinical practice.
authors.affiliation: Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, U.S.A.
authors.forename: Zhuokai
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Biostatistics, Indiana University Schools of Medicine and Public Health, 410 West 10th Street, Indianapolis, IN 46202, U.S.A.
authors.forename: Hai
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Biostatistics, Indiana University Schools of Medicine and Public Health, 410 West 10th Street, Indianapolis, IN 46202, U.S.A.
authors.forename: Wanzhu
authors.initials: W
authors.lastname: Tu
mesh_terms: D000293:Adolescent; D000465:Algorithms; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000706:statistics & numerical data; D012372:ROC Curve; D012044:Regression Analysis; D012749:Sexually Transmitted Diseases / Q000175:diagnosis*
keywords: bivariate surfaces; multiple binary outcomes; penalized likelihood; resampling; splines