title: Cell and Tissue Imaging with Molecularly Imprinted Polymers as Plastic Antibody Mimics.
abstract: Molecularly imprinted polymers can be used as "plastic antibodies" for cell and tissue imaging, as demonstrated using hyaluronan on cell surfaces as a model target. Fluorescent nanoparticles binding a hyaluronan substructure, glucuronic acid, are used to image fixated and living cells and tissues. Plastic antibodies can be tailored to specific targets and easily labeled, and are physically and chemically stable.
authors.affiliation: Sorbonne Universités, Université de Technologie de, Compiègne, CNRS Institute for Enzyme and Cell Engineering, CS30319, 60203, Compiègne, France.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Kunath
authors.affiliation: Sorbonne Universités, Université de Technologie de, Compiègne, CNRS Institute for Enzyme and Cell Engineering, CS30319, 60203, Compiègne, France.
authors.forename: Maria
authors.initials: M
authors.lastname: Panagiotopoulou
authors.affiliation: Sorbonne Universités, Université de Technologie de, Compiègne, CNRS Institute for Enzyme and Cell Engineering, CS30319, 60203, Compiègne, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Maximilien
authors.affiliation: Sorbonne Universités, Université de Technologie de, Compiègne, CNRS Institute for Enzyme and Cell Engineering, CS30319, 60203, Compiègne, France.
authors.forename: Nataliya
authors.initials: N
authors.lastname: Marchyk
authors.affiliation: Institute of Pathology Bad Berka, Robert-Koch-Allee 9, 99438, Bad Berka, Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Sänger
authors.affiliation: Sorbonne Universités, Université de Technologie de, Compiègne, CNRS Institute for Enzyme and Cell Engineering, CS30319, 60203, Compiègne, France.
authors.forename: Karsten
authors.initials: K
authors.lastname: Haupt
mesh_terms: D000906:Antibodies / Q000737:chemistry*; D063566:Biodegradable Plastics / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry*; D002478:Cells, Cultured; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism*; D008856:Microscopy, Fluorescence / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D012867:Skin / Q000166:cytology / Q000378:metabolism*
chemical_list: D000906:Antibodies; D063566:Biodegradable Plastics; D005456:Fluorescent Dyes
keywords: bioimaging; molecular imprinting; synthetic receptors