title: Psoriasis Phenotype in Inflammatory Bowel Disease: A Case-Control Prospective Study.
abstract: OBJECTIVE
  Whether inflammatory bowel disease [IBD] is associated with specific psoriasis phenotypes is undefined. In a case-control prospective study, we aimed to assess the severity and phenotype of psoriasis in IBD vs matched non-IBD controls with psoriasis [non-IBD].
  
  
  METHODS
  From 2011 to 2013, dermatological assessment was performed in all IBD patients showing lesions requiring characterisation. In patients with psoriasis, assessment included: presence, characteristics, and severity. Each IBD patient with psoriasis was matched [gender, ethnicity, age ± 5 years] with one non-IBD patient with psoriasis.
  
  
  METHODS
  data were expressed as median [range], chi-square, Student's t test.
  
  
  RESULTS
  Dermatological assessment was performed in 251 IBD patients [115 females, age 47 [16-85]; IBD duration 9 years [1-46]]: 158 Crohn's disease [CD] [63%], 93 ulcerative colitis [UC] [37%]. Psoriasis was detected in 62 [25%] IBD patients: 36 [58%] CD, 26 UC [42%; p = 0.44]. Clinical characteristics were comparable between IBD patients with or without psoriasis: age 50 [23-72] vs 47 [16-85]; IBD duration 9.5 [1-46] vs 9 [1-41]; p = non-significant]. The non-IBD group included 62 patients with psoriasis: 35 male; age 47 [18-75]. Mild psoriasis was more frequent in IBD vs non-IBD [87% vs 53%; p < 0.0001], whereas moderate and severe psoriasis were more frequent in non-IBD vs IBD [37% vs 13%, p = 0.004; 10% vs 0%; p = 0.036]. Plaque-type psoriasis was the most common phenotype in both IBD and non-IBD [p < 0.0001 vs others phenotypes].The frequency of plaque-type, nail psoriasis and psoriatic arthritis was lower in IBD vs non-IBD [p = 0.008; p < 0.0001; p = 0.006]. Psoriasis occurred after anti-tumour necrosis factor [TNF]α treatment in six CD patients [7%].
  
  
  CONCLUSIONS
  Severity and phenotypes of psoriasis may differ between patients with IBD and their matched non-IBD controls.
authors.affiliation: GI Unit, Department of Systems Medicine, University Tor Vergata of Rome, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Lolli
authors.affiliation: Department of Dermatology, University of Rome Tor Vergata, Italy.
authors.forename: Rosita
authors.initials: R
authors.lastname: Saraceno
authors.affiliation: GI Unit, Department of Systems Medicine, University Tor Vergata of Rome, Italy.
authors.forename: Emma
authors.initials: E
authors.lastname: Calabrese
authors.affiliation: GI Unit, Department of Systems Medicine, University Tor Vergata of Rome, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Ascolani
authors.affiliation: GI Unit, Department of Systems Medicine, University Tor Vergata of Rome, Italy.
authors.forename: Patrizio
authors.initials: P
authors.lastname: Scarozza
authors.affiliation: Department of Dermatology, University of Rome Tor Vergata, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Chiricozzi
authors.affiliation: GI Unit, Department of Systems Medicine, University Tor Vergata of Rome, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Onali
authors.affiliation: GI Unit, Department of Systems Medicine, University Tor Vergata of Rome, Italy.
authors.forename: Carmelina
authors.initials: C
authors.lastname: Petruzziello
authors.affiliation: Department of Dermatology, University of Rome Tor Vergata, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Chimenti
authors.affiliation: GI Unit, Department of Systems Medicine, University Tor Vergata of Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pallone
authors.affiliation: GI Unit, Department of Systems Medicine, University Tor Vergata of Rome, Italy biancone@med.uniroma2.it.
authors.forename: Livia
authors.initials: L
authors.lastname: Biancone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011446:Prospective Studies; D011565:Psoriasis / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Crohn’s disease; phenotype; psoriasis; severity; ulcerative colitis