title: Time-dependent periimplant bone reaction of acidic monomer-treated injection molded zirconia implants in rabbit tibiae.
abstract: OBJECTIVE
  The aim of this study was to evaluate and compare the osseointegration of zirconia implants in rabbit tibiae with and without 10-methacryloyloxydecyl dihydrogen phosphate (MDP) treatment.
  
  
  METHODS
  Twenty-eight rabbits received a total of 112 external hex-type implants made by the powder injection molding technique with and without MDP treatment before installation in the tibiae. The contact angles on the zirconia implants and zirconia discs before and after MDP application were evaluated. Removal torque (RT) and bone-implant contact (BIC) ratios were measured.
  
  
  RESULTS
  The MDP treatment markedly enhanced the hydrophilicity and seemed to alter the topography and chemical composition of the implant and disc surface. As the healing time increases, the BIC and RT were increased in both groups. The MDP-treated implants exhibited higher BIC values than the control implants after 2 and 4 weeks of healing. The RT was higher in MDP-treated implants after 2 weeks of healing but not after 4 weeks of healing.
  
  
  CONCLUSIONS
  The 10-MDP treatments made the surface more hydrophilic and enhanced the osseointegration of the implants in the early healing phase.
authors.affiliation: *Associate Professor, Department of Conservative Dentistry, Dental Research Institute and School of Dentistry, Seoul National University, Seoul, Korea. †Professor, Department of Dental Pharmacology and Therapeutics, Dental Research Institute and School of Dentistry, Seoul National University, Seoul, Korea. ‡Graduate Student, Department of Oral Anatomy, Dental Research Institute and School of Dentistry, Seoul National University, Seoul, Korea. §Associate Professor, Department of Prosthodontics, Dental Research Institute and School of Dentistry, Seoul National University, Seoul, Korea. ‖Associate Professor, Department of Periodontology, School of Dentistry, Kyung Hee University, Seoul, Korea. ¶Assistant Professor, Department of Oral Anatomy, Dental Research Institute and School of Dentistry, Seoul National University, Seoul, Korea.
authors.forename: Won-Jun
authors.initials: WJ
authors.lastname: Shon
authors.forename: Kyung Mi
authors.initials: KM
authors.lastname: Woo
authors.forename: Hong-Kyun
authors.initials: HK
authors.lastname: Kim
authors.forename: Ho Beom
authors.initials: HB
authors.lastname: Kwon
authors.forename: Seung-Yun
authors.initials: SY
authors.lastname: Shin
authors.forename: Young-Seok
authors.initials: YS
authors.lastname: Park
mesh_terms: D000818:Animals; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D003799:Dental Stress Analysis; D008297:Male; D008689:Methacrylates / Q000627:therapeutic use*; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D011817:Rabbits; D013977:Tibia / Q000601:surgery*; D013997:Time Factors; D015040:Zirconium
chemical_list: D015921:Dental Implants; D008689:Methacrylates; C069749:methacryloyloxydecyl dihydrogen phosphate; D015040:Zirconium; C028541:zirconium oxide