title: Neural regulation of hematopoiesis, inflammation, and cancer.
abstract: Although the function of the autonomic nervous system (ANS) in mediating the flight-or-fight response was recognized decades ago, the crucial role of peripheral innervation in regulating cell behavior and response to the microenvironment has only recently emerged. In the hematopoietic system, the ANS regulates stem cell niche homeostasis and regeneration and fine-tunes the inflammatory response. Additionally, emerging data suggest that cancer cells take advantage of innervating neural circuitry to promote their progression. These new discoveries outline the need to redesign therapeutic strategies to target this underappreciated stromal constituent. Here, we review the importance of neural signaling in hematopoietic homeostasis, inflammation, and cancer.
authors.affiliation: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Maher
authors.initials: M
authors.lastname: Hanoun
authors.affiliation: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Maryanovich
authors.affiliation: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Arnal-Estapé
authors.affiliation: Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: paul.frenette@einstein.yu.edu.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Frenette
mesh_terms: D001341:Autonomic Nervous System / Q000502:physiology* / Q000503:physiopathology*; D001342:Autonomic Nervous System Diseases / Q000453:epidemiology*; D001853:Bone Marrow / Q000294:innervation; D015897:Comorbidity; D003863:Depression / Q000453:epidemiology; D006410:Hematopoiesis / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000453:epidemiology / Q000503:physiopathology*; D007951:Leukemia, Myeloid / Q000453:epidemiology / Q000503:physiopathology; D009369:Neoplasms / Q000453:epidemiology* / Q000503:physiopathology*; D009479:Neuropeptides / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D013315:Stress, Psychological / Q000453:epidemiology; D015996:Survival Rate
chemical_list: D009479:Neuropeptides; D018377:Neurotransmitter Agents