title: Influence of simvastatin-loaded implants on osseointegration in an ovariectomized animal model.
abstract: The success of bone implants in the presence of osteoporosis is limited by lack of osseointegration between the implant and the natural bone. This study applied an electrochemical process to deposit simvastatin-nanohydroxyapatite (HA) coatings on porous implant surfaces and investigated the effects of these simvastatin-HA coatings on implant surfaces in an animal model of osteoporosis. In this study, simvastatin-HA coated implants were inserted into the tibia of osteoporotic rats. After 2, 4, and 12 weeks, tissue was retrieved for histomorphometric evaluation. The results indicated that the simvastatin-HA coatings increased bone-implant contact and new bone formation around implant surfaces. In conclusion, implants loaded with simvastatin by an electrochemical process improved implant osseointegration in osteoporotic rats. Furthermore, the increased concentration of simvastatin could affect the osseointegration, but the dose-effects also need further investigation.
authors.affiliation: School of Medicine, Zhejiang University, Yan'an Road, Hangzhou 310000, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Fang
authors.affiliation: Department of Implantology, Stomatology Hospital, School of Medicine, Zhejiang University, Yan'an Road, Hangzhou 310000, China.
authors.forename: Shifang
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of Implantology, Stomatology Hospital, School of Medicine, Zhejiang University, Yan'an Road, Hangzhou 310000, China.
authors.forename: Fuming
authors.initials: F
authors.lastname: He
authors.affiliation: Department of Prosthodontics, Stomatology Hospital, School of Medicine, Zhejiang University, Yan'an Road, Hangzhou 310000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Implantology, Stomatology Hospital, School of Medicine, Zhejiang University, Yan'an Road, Hangzhou 310000, China.
authors.forename: Guoli
authors.initials: G
authors.lastname: Yang
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D017886:Durapatite / Q000494:pharmacology; D005260:Female; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D020007:Implants, Experimental; D016348:Osseointegration / Q000187:drug effects*; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D019821:Simvastatin / Q000494:pharmacology*
chemical_list: D020099:Coated Materials, Biocompatible; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017886:Durapatite; D019821:Simvastatin