title: Tailoring highly branched poly(β-amino ester)s: a synthetic platform for epidermal gene therapy.
abstract: Highly branched poly(β-amino ester)s (HPAEs) were designed and synthesised for safe and efficient gene delivery to human keratinocytes. HPAEs outperformed commercial transfection reagents: PEI and SuperFect®, for both transfection efficiency and biocompatibility. A 22 and 3.4 fold enhancement of gene transfection was seen coupled with superior biocompatibility.
authors.affiliation: Charles Institute of Dermatology, University College Dublin, Dublin 4, Ireland. dezhong.zhou@ucd.ie wenxin.wang@ucd.ie.
authors.forename: Jian-Yuan
authors.initials: JY
authors.lastname: Huang
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Gao
authors.forename: Lara
authors.initials: L
authors.lastname: Cutlar
authors.forename: Jonathan
authors.initials: J
authors.lastname: O'Keeffe-Ahern
authors.forename: Tianyu
authors.initials: T
authors.lastname: Zhao
authors.forename: Feng-Huei
authors.initials: FH
authors.lastname: Lin
authors.forename: Dezhong
authors.initials: D
authors.lastname: Zhou
authors.forename: Sean
authors.initials: S
authors.lastname: McMahon
authors.forename: Udo
authors.initials: U
authors.lastname: Greiser
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Wenxin
authors.initials: W
authors.lastname: Wang
mesh_terms: D002470:Cell Survival; D004952:Esters; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D008156:Luciferases / Q000235:genetics; D011108:Polymers / Q000737:chemistry
chemical_list: D004952:Esters; D011108:Polymers; D008156:Luciferases