title: Tumor-targeted Delivery of Anti-microRNA for Cancer Therapy: pHLIP is Key.
abstract: pHLIP opens the door to the cell: An improved cytosolic transfer of anti-microRNAs (anti-miRs) against onco-miRs paves the way for future cancer therapies. The employed anti-miR-peptide conjugates are based on peptide nucleic acids (PNAs), which are connected with the membrane translocation peptide pHLIP through a disulfide bond. The PNAs are thus transferred into the cell and released by the cleavage of the S-S bond.
authors.affiliation: Department for Pharmacy and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstrasse 5-13, 81377 Munich (Germany); Nanosystems Initiative Munich (NIM), Schellingstrasse 4, 80799 Munich (Germany). ernst.wagner@cup.uni-muenchen.de.
authors.forename: Ernst
authors.initials: E
authors.lastname: Wagner
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D020135:Peptide Nucleic Acids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry*
chemical_list: D035683:MicroRNAs; D020135:Peptide Nucleic Acids; D010455:Peptides
keywords: RNA; membranes; microRNA; peptide nucleic acids; targeted delivery