title: α-Synuclein pathology accumulates in sacral spinal visceral sensory pathways.
abstract: Urinary urgency and frequency are common in α-synucleinopathies such as Parkinson disease, Lewy body dementia, and multiple system atrophy. These symptoms cannot be managed with dopamine therapy, and their underlying pathophysiology is unclear. We show that in individuals with Parkinson disease, Lewy body dementia, or multiple system atrophy, α-synuclein pathology accumulates in the lateral collateral pathway, a region of the sacral spinal dorsal horn important for the relay of pelvic visceral afferents. Deposition of α-synuclein in this region may contribute to impaired micturition and/or constipation in Parkinson disease and other α-synucleinopathies.
authors.affiliation: Departments of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
authors.forename: Veronique G
authors.initials: VG
authors.lastname: VanderHorst
authors.affiliation: Departments of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
authors.forename: Tamara
authors.initials: T
authors.lastname: Samardzic
authors.affiliation: Departments of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
authors.forename: Clifford B
authors.initials: CB
authors.lastname: Saper
authors.affiliation: Departments of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.|Departments of Neurology Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Anderson
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.|Department of Pathology, Rush University Medical Center, Chicago, IL.
authors.forename: Sukriti
authors.initials: S
authors.lastname: Nag
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.|Department of Pathology, Rush University Medical Center, Chicago, IL.|Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Schneider
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.|Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
authors.forename: David A
authors.initials: DA
authors.lastname: Bennett
authors.affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.|Department of Neurological Sciences, Rush University Medical Center, Chicago, IL.
authors.forename: Aron S
authors.initials: AS
authors.lastname: Buchman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000378:metabolism / Q000473:pathology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020961:Lewy Body Disease / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D010300:Parkinson Disease / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D012447:Sacrum; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology; D066148:Spinal Cord Dorsal Horn / Q000378:metabolism* / Q000473:pathology; D013904:Thoracic Vertebrae; D014549:Urinary Incontinence / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D017833:Visceral Afferents / Q000378:metabolism* / Q000473:pathology; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein