title: Changes in Peripheral Blood Monocytes and Liver Macrophages in Male Rats after Benzo(a)pyrene Injection.
abstract: Intraperitoneal injections of benzo(a)pyrene to male rats in a total dose of 60 mg/kg modified the production of ROS and the phagocytic potential of blood monocytes by modulating their potential bactericidal activity. The lysosomal system (particularly the secondary lysosomes) of liver macrophages was activated, which promoted fusion of the hydrolytic potentials of macrophages and monocytes. These results indicated that the toxin modulated the cellular immune homeostasis and the level of general nonspecific resistance.
authors.affiliation: Research Center of Family Health Problems and Human Reproduction, Irkutsk, Russia, sikolesnikov2012@gmail.com.
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
authors.forename: S V
authors.initials: SV
authors.lastname: Michurina
authors.forename: S A
authors.initials: SA
authors.lastname: Arkhipov
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000494:pharmacology*; D007155:Immunologic Factors / Q000494:pharmacology*; D007728:Kupffer Cells / Q000187:drug effects; D008099:Liver / Q000166:cytology*; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D009000:Monocytes / Q000187:drug effects*; D051381:Rats
chemical_list: D007155:Immunologic Factors; D001564:Benzo(a)pyrene