title: A review of fluorescent ligands for studying 5-HT3 receptors.
abstract: The use of fluorescence is a valuable and increasingly accessible means of probing the pharmacology and physiology of cells and their receptors. To date, the use of fluorescence-based methods for 5-HT3 receptor research has been quite limited and, although a variety of approaches have been described, these are broadly distributed throughout the literature. In this review we condense these findings into a single, accessible source of reference with the hope of promoting the use of these valuable molecular probes. This article is part of the Special Issue entitled 'Fluorescent Tools in Neuropharmacology'.
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Bern, Switzerland. Electronic address: martin.lochner@dcb.unibe.ch.
authors.forename: Martin
authors.initials: M
authors.lastname: Lochner
authors.affiliation: Department of Pharmacology, Tennis Court Road, Cambridge, CB2 1PD, UK. Electronic address: ajt44@cam.ac.uk.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Thompson
mesh_terms: D000818:Animals; D005434:Flow Cytometry; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D006801:Humans; D008024:Ligands; D044406:Receptors, Serotonin, 5-HT3 / Q000378:metabolism*
chemical_list: D005456:Fluorescent Dyes; D008024:Ligands; D044406:Receptors, Serotonin, 5-HT3
keywords: 5-HT(3) receptor; Flow cytometry; Fluorescence polarisation; Fluorescent ligand; Imaging; Synthesis