title: Glatiramer acetate-induced hepatitis in a young female patient with multiple sclerosis.
abstract: We report the first Italian case of glatiramer acetate-related acute hepatotoxicity. A 25-years-old woman suffering from multiple sclerosis presented acute hepatitis after eight months of treatment. Neither infective, nor autoimmune markers were detected. Liver biopsy histology was consistent with drug-induced acute injury. Liver function tests became normal after eight weeks of treatment discontinuation. This report points out the importance of monitoring liver function during the first year of treatment with glatiramer acetate.
authors.affiliation: Department of Neuroscience, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy. Electronic address: saralagioia@yahoo.it.
authors.forename: Sara
authors.initials: S
authors.lastname: La Gioia
authors.affiliation: Antivenom Center, Clinical Toxicology Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bacis
authors.affiliation: Department of Pathology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Aurelio
authors.initials: A
authors.lastname: Sonzogni
authors.affiliation: Department of Neuroscience, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Frigeni
authors.affiliation: Department of Neuroscience, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Marta Zaffira
authors.initials: MZ
authors.lastname: Conti
authors.affiliation: Department of Neuroscience, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Marcella
authors.initials: M
authors.lastname: Vedovello
authors.affiliation: Department of Neuroscience, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Mariarosa
authors.initials: M
authors.lastname: Rottoli
mesh_terms: D000276:Adjuvants, Immunologic / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D005260:Female; D000068717:Glatiramer Acetate; D006505:Hepatitis / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007558:Italy; D008099:Liver / Q000473:pathology / Q000503:physiopathology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications / Q000188:drug therapy*; D010455:Peptides / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D010455:Peptides; D000068717:Glatiramer Acetate
keywords: Glatiramer acetate; Hepatitis; Multiple sclerosis; Toxicity