title: Transcatheter Closure of Perimembranous Ventricular Septal Defects with Left Ventricular to Right Atrial Shunt.
abstract: During the development of so-called aneurysmal transformation of perimembranous ventricular septal defects (pmVSD), tricuspid valve (TV) morphology and function may be altered resulting in left ventricular (LV) to right atrial (RA) shunting. The feasibility and outcome of interventional closure of these pmVSD has not been investigated so far. Interventional closure of pmVSD associated with mild to moderate LV-to-RA shunt was performed in four patients (aged 6.5-12.5 years). pmVSD were closed under fluoroscopic guidance by establishing an arteriovenous wire loop via a femoral artery and advancing the delivery sheath from a femoral vein. Before device release (or withdrawal if necessary), residual shunting across the device and TV valve function was investigated by transthoracic echocardiography and LV angiography. pmVSD sizes of 4, 5.5, 8 and 8.5 mm were closed with a 4/4 and 6/6 Amplatzer duct occluder II and an 8- and 10-mm Amplatzer muscular VSD occluder device, respectively. There were no or only minor residual postinterventional LV-to-RA shunts. No atrioventricular blocks were observed during a mean follow-up of 12.5 months (range 6.5-17 months). Transthoracic echocardiography indicated that the elimination of the VSD jet pushing the antero-superior TV leaflet open is the key mechanism for LV-to-RA shunt reduction after transcatheter pmVSD closure. Interventional closure in pmVSD associated with mild to moderate indirect LV-to-RA shunting is feasible and results in significant reduction in or elimination of LV-to-RA shunting.
authors.affiliation: Department of Pediatric Cardiology, Pediatric Heart Center Giessen, University Children's Hospital, Feulgenstr. 10-12, 35392, Giessen, Germany. gunter.kerst@paediat.med.uni-giessen.de.
authors.forename: Gunter
authors.initials: G
authors.lastname: Kerst
authors.affiliation: Department of Pediatric Cardiology, Pediatric Heart Center Giessen, University Children's Hospital, Feulgenstr. 10-12, 35392, Giessen, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Moysich
authors.affiliation: Cardiac Morphology Unit, Royal Brompton Hospital, Imperial College London, London, UK.
authors.forename: Siew Yen
authors.initials: SY
authors.lastname: Ho
authors.affiliation: Department of Pediatric Cardiology, Pediatric Heart Center Giessen, University Children's Hospital, Feulgenstr. 10-12, 35392, Giessen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Apitz
authors.affiliation: Department of Pediatric Cardiology, Pediatric Heart Center Giessen, University Children's Hospital, Feulgenstr. 10-12, 35392, Giessen, Germany.
authors.forename: Heiner
authors.initials: H
authors.lastname: Latus
authors.affiliation: Department of Pediatric Cardiology, Pediatric Heart Center Giessen, University Children's Hospital, Feulgenstr. 10-12, 35392, Giessen, Germany.
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schranz
mesh_terms: D020517:Atrial Appendage / Q000000981:diagnostic imaging*; D006328:Cardiac Catheterization / Q000379:methods*; D002648:Child; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging* / Q000601:surgery*; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D011474:Prosthesis Design; D055989:Septal Occluder Device; D016896:Treatment Outcome
keywords: Congenital heart disease; Gerbode defect; Interventional cardiology; Perimembranous ventricular septal defect