title: Simvastatin improves hematopoietic stem cell engraftment by preventing irradiation-induced marrow adipogenesis and radio-protecting the niche cells.
authors.affiliation: Stem Cell Lab, National Centre for Cell Science, Pune, India.
authors.forename: Manmohan S
authors.initials: MS
authors.lastname: Bajaj
authors.affiliation: Stem Cell Lab, National Centre for Cell Science, Pune, India.
authors.forename: Suprita S
authors.initials: SS
authors.lastname: Ghode
authors.affiliation: Stem Cell Lab, National Centre for Cell Science, Pune, India.
authors.forename: Rohan S
authors.initials: RS
authors.lastname: Kulkarni
authors.affiliation: Stem Cell Lab, National Centre for Cell Science, Pune, India.
authors.forename: Lalita S
authors.initials: LS
authors.lastname: Limaye
authors.affiliation: Stem Cell Lab, National Centre for Cell Science, Pune, India vpkale@nccs.res.in vaijayanti.kale@gmail.com.
authors.forename: Vaijayanti P
authors.initials: VP
authors.lastname: Kale
mesh_terms: D050156:Adipogenesis / Q000187:drug effects* / Q000528:radiation effects; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D006085:Graft Survival / Q000187:drug effects* / Q000528:radiation effects; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D019821:Simvastatin / Q000494:pharmacology*; D055153:Stem Cell Niche / Q000187:drug effects* / Q000528:radiation effects; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods
chemical_list: D011837:Radiation-Protective Agents; D019821:Simvastatin
keywords: HSC engraftment; HSC-Niche; marrow adipogenesis; radioprotection; simvastatin