title: Breast carcinoma originating from a silicone granuloma: a case report.
abstract: Breast carcinoma rarely occurs in cases of foreign body granulomas following liquid silicone injection. Although the Food and Drug Administration (FDA) banned the use of all silicone injection products in 1992, liquid silicone injection for breast augmentation continues to be performed illegally. We herein report a case of breast carcinoma following liquid silicone injection in a 67-year-old female.A total of 45 years after liquid silicone injection, the patient had felt a breast mass in the right breast. Mammography showed a smooth mass that retracted the right nipple. Due to the presence of a marked acoustic shadow caused by the granulomas, evaluating the mass on ultrasonography was difficult. However, magnetic resonance imaging (MRI) showed a lobulated mass under the right nipple. The mass exhibited low signal intensity (SI) on T1-weighted images and intermingled high and low SI on T2-weighted images. Heterogeneous early enhancement with central low intensity was noted on dynamic contrast-enhanced MRI. Several oval-shaped low SI structures in the adipose tissue and disruption of the pectoralis major muscle were also observed. We diagnosed the patient with invasive ductal carcinoma based on a stereotactic-guided Mammotome® (a vacuum-assisted biopsy system manufactured by DEVICOR MEDICAL JAPAN, Tokyo, Japan) biopsy and subsequently performed mastectomy and axillary lymph node dissection (with a positive result for the sentinel node biopsy). Histologically, invasive ductal carcinoma was observed in the silicone granuloma.The development of foreign body granulomas following breast augmentation usually makes it difficult to detect breast cancer; thus, various devices are required to confirm the histological diagnosis of breast lesions. The stereotactic-guided Mammotome® biopsy system may be an effective device for diagnosing breast cancer developing in the augmented breast.
authors.affiliation: Department of Breast Care Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuou-ku, Fukuoka, Japan. nakahori@kyumed.jp.|Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Chigyouhama, Chuou-ku, Fukuoka, Japan. nakahori@kyumed.jp.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Nakahori
authors.affiliation: Department of Breast Care Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuou-ku, Fukuoka, Japan. ryuji@kyumed.jp.|Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Chigyouhama, Chuou-ku, Fukuoka, Japan. ryuji@kyumed.jp.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Takahashi
authors.affiliation: Department of Breast Care Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuou-ku, Fukuoka, Japan. momokoakashi@kyumed.jp.|Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Chigyouhama, Chuou-ku, Fukuoka, Japan. momokoakashi@kyumed.jp.
authors.forename: Momoko
authors.initials: M
authors.lastname: Akashi
authors.affiliation: Department of Breast Care Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuou-ku, Fukuoka, Japan. kanak@qmed.hosp.go.jp.|Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Chigyouhama, Chuou-ku, Fukuoka, Japan. kanak@qmed.hosp.go.jp.
authors.forename: Kana
authors.initials: K
authors.lastname: Tsutsui
authors.affiliation: Department of Breast Care Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuou-ku, Fukuoka, Japan. s-harada@kyumed.jp.|Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Chigyouhama, Chuou-ku, Fukuoka, Japan. s-harada@kyumed.jp.
authors.forename: Shino
authors.initials: S
authors.lastname: Harada
authors.affiliation: Department of Breast Care Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuou-ku, Fukuoka, Japan. rokan@kyumed.jp.|Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Chigyouhama, Chuou-ku, Fukuoka, Japan. rokan@kyumed.jp.
authors.forename: Roka Namoto
authors.initials: RN
authors.lastname: Matsubayashi
authors.affiliation: Department of Breast Care Center, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama, Chuou-ku, Fukuoka, Japan. shino220@kyumed.jp.|Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Chigyouhama, Chuou-ku, Fukuoka, Japan. shino220@kyumed.jp.
authors.forename: Shino
authors.initials: S
authors.lastname: Nakagawa
authors.affiliation: Clinical Research Institute, National Hospital Organization Kyushu Medical Center, 1-8-1 Chigyouhama, Chuou-ku, Fukuoka, Japan. momos5@kyumed.jp.|Department of Pathology, National Hospital Organization Kyushu Medical Center, 1-8-1 Chigyouhama, Chuou-ku, Fukuoka, Japan. momos5@kyumed.jp.
authors.forename: Seiya
authors.initials: S
authors.lastname: Momosaki
authors.affiliation: Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Kurume, Japan. yoshisg@med.kurume-u.ac.jp.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Akagi
mesh_terms: D000368:Aged; D018427:Breast Implants / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000209:etiology* / Q000473:pathology; D005260:Female; D015745:Granuloma, Foreign-Body / Q000209:etiology*; D006801:Humans; D011379:Prognosis; D012828:Silicones / Q000009:adverse effects*
chemical_list: D012828:Silicones