title: Mutual interdependence of splicing and transcription elongation.
abstract: Transcription and splicing are intrinsically linked, as splicing needs a pre-mRNA substrate to commence. The more nuanced view is that the rate of transcription contributes to splicing regulation. On the other hand there is accumulating evidence that splicing has an active role in controlling transcription elongation by DNA-dependent RNA polymerase II (RNAP II). We briefly review those mechanisms and propose a unifying model where splicing controls transcription elongation to provide an optimal timing for successive rounds of splicing.
authors.affiliation: a Institute of Biochemistry and Biophysics; Polish Academy of Sciences ; Warsaw , Poland.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Brzyżek
authors.forename: Szymon
authors.initials: S
authors.lastname: Świeżewski
mesh_terms: D002843:Chromatin / Q000235:genetics; D006801:Humans; D012319:RNA Polymerase II / Q000235:genetics*; D012326:RNA Splicing / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D012319:RNA Polymerase II
keywords: Eukaryotic transcription; PolII; chromatin and transcription; chromatin marks; co-trancriptional splicing; splicing; transcription and RNA processing; transcription elongation