title: Association of high-density lipoprotein with development of metabolic syndrome components: a five-year follow-up in adults.
abstract: BACKGROUND
  High-density lipoprotein (HDL) is associated with the incidence of metabolic syndrome (MetS). It is unclear whether subjects with different HDL levels develop different components of MetS over time. Our study aimed to determine what MetS components tend to emerge and change relative to different levels of HDL.
  
  
  METHODS
  During the period 2007 to 2012, 4,905 adults in Tongren and Xiaotangshan Hospitals in Beijing were included with no MetS, self-reported type 2 diabetes, or cardiovascular disease at baseline. An association rule was used to determine the changes of MetS components over time.
  
  
  RESULTS
  The incidence of MetS at follow-up was 3.40% for men and 1.50% for women in the high-normal HDL group; 6.65% and 4.55%, respectively, in the normal HDL group; and 11.05% and 6.45%, respectively, in the low HDL group. The most common transition was from healthy to healthy in normal-high or normal HDL groups (47.2% to 63.8%), whereas 11.7% to 39.9% of subjects with low HDL returned to healthy status or stayed unchanged in the low HDL group. The most common new-onset components were elevated blood pressure (9.2 to 10.0%), elevated high-density lipoprotein (5.5 to 11.0%), and raised fasting glucose (5.4 to 5.5%) in the groups with normal-high or normal HDL.
  
  
  CONCLUSIONS
  The incidence of MetS increased in parallel with the decrease in HDL. Adults with a low HDL level were more susceptible to developing MetS over time. Low HDL seemed to be a pre-existing phase of MetS and may be a crucial status for MetS prevention.
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. lxiangtong@163.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. lxiangtong@163.com.
authors.forename: Xiangtong
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. taolixin.2008@163.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. taolixin.2008@163.com.
authors.forename: Lixin
authors.initials: L
authors.lastname: Tao
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. anzhen602@163.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. anzhen602@163.com.
authors.forename: Kai
authors.initials: K
authors.lastname: Cao
authors.affiliation: Physical Examination Department, Beijing Tongren Hospital Affiliated to Capital Medical University, No.1 Dongjiao Minxiang, Dongcheng District, Beijing, 100730, China. wangzp@trhos.com.
authors.forename: Zhaoping
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Physical Examination Department, Beijing Tongren Hospital Affiliated to Capital Medical University, No.1 Dongjiao Minxiang, Dongcheng District, Beijing, 100730, China. chendn@trhos.com.
authors.forename: Dongning
authors.initials: D
authors.lastname: Chen
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. guojin5827501@163.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. guojin5827501@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Guo
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. zhuhuiping79@163.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. zhuhuiping79@163.com.
authors.forename: Huiping
authors.initials: H
authors.lastname: Zhu
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. xinghuay@263.net.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. xinghuay@263.net.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Yang
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. wangy@ccmu.edu.cn.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. wangy@ccmu.edu.cn.
authors.forename: Youxin
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. wjj00a@126.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. wjj00a@126.com.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. 13810147054@139.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. 13810147054@139.com.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. liulongbinzhou@126.com.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. liulongbinzhou@126.com.
authors.forename: Long
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, China. guoxiuh@ccmu.edu.cn.|Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China. guoxiuh@ccmu.edu.cn.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D000068476:Beijing; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology*; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D008075:Lipoproteins, HDL