title: Diet-based strategies for cancer chemoprevention: the role of combination regimens using dietary bioactive components.
abstract: Chemopreventive agents that the general population can consume for prolonged periods of time with minimal risk of any side effects are of great interest to all in search of a solution to the pervasive incidence of cancer. Dietary bioactive components have been found to modulate many deregulated molecular pathways associated with the initiation and progression of different types of cancer. Combination regimens with dietary bioactive components are a promising strategy for cancer chemoprevention because they may offer enhanced protective effects against cancer development but cause little or no adverse effects. This article provides an overview of studies examining the combination of dietary bioactive components for the chemoprevention of major types of cancer. A better understanding of existing research on the combination of dietary bioactive components will provide an important basis for the rational design of future combination studies and the successful development of cancer chemoprevention strategies.
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, Massachusetts 01003; email: hangxiao@foodsci.umass.edu.
authors.forename: Christina
authors.initials: C
authors.lastname: DiMarco-Crook
authors.forename: Hang
authors.initials: H
authors.lastname: Xiao
mesh_terms: D018890:Chemoprevention; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000145:classification / Q000178:diet therapy* / Q000517:prevention & control
keywords: breast cancer; cancer chemoprevention; colorectal cancer; combination; dietary bioactive components; lung cancer; prostate cancer; synergy; whole foods