title: High Familial Correlation in Methylphenidate Response and Side Effect Profile.
abstract: To examine whether a familial tendency exists in clinical response to methylphenidate.
  
  
  
  Nineteen pairs of siblings or parent-child stimulant-naive individuals with ADHD were prescribed methylphenidate-immediate release, and were comprehensively evaluated at baseline, Week 2, and Week 4, using the ADHD Rating Scale IV, Clinical Global Impression Scale, and the Barkley Side Effects Rating Scale.
  
  
  
  We found significant intraclass correlations in family member response to methylphenidate-immediate release and side effect profile, including emotional symptoms and loss of appetite and weight.
  
  
  
  Family history of response to methylphenidate should be taken into account when treating ADHD.
authors.affiliation: 1 Tel Aviv University, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Gazer-Snitovsky
authors.affiliation: 1 Tel Aviv University, Israel.
authors.forename: Ayelet
authors.initials: A
authors.lastname: Brand-Gothelf
authors.affiliation: 1 Tel Aviv University, Israel.|2 The Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel.
authors.forename: Gal
authors.initials: G
authors.lastname: Dubnov-Raz
authors.affiliation: 1 Tel Aviv University, Israel.|3 Geha Mental Health Center & Felsenstein Medical Research Center, Petah Tikva, Israel.
authors.forename: Abraham
authors.initials: A
authors.lastname: Weizman
authors.affiliation: 1 Tel Aviv University, Israel.|2 The Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel.
authors.forename: Doron
authors.initials: D
authors.lastname: Gothelf
mesh_terms: D000293:Adolescent; D000328:Adult; D001066:Appetite / Q000187:drug effects; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics* / Q000523:psychology; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects / Q000627:therapeutic use*; D010290:Parents; D035781:Siblings; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate
keywords: ADHD; familial; methylphenidate; response; side effects