title: Aggressive multimodality treatment for advanced rectal cancer.
abstract: A case of advanced rectal cancer treated by aggressive local and systemic treatment who has survived more than 7 years from initial recurrence is presented. A 55-year-old woman was diagnosed with advanced lower rectal cancer and underwent a low anterior resection with complete removal of all regional lymph nodes and total mesorectal excision. The tumor was diagnosed as a moderately differentiated adenocarcinoma, pStage IIIB (T3, N2a, M0). Twenty-six months after the initial surgery, local recurrence in the pelvis was detected by computed tomography, and total pelvic exenteration with distal sacrectomy (TPES) was performed after systemic chemotherapy with a molecular-targeted drug. Six months after the TPES, multiple lung metastases were detected. Consequently, the patient underwent radiofrequency ablation (RFA) and chemotherapy. The disease has since been controlled for 38 months. As volume control is essential for cancer treatment, it may be important to combine appropriate local therapy with systemic therapy to metastatic or recurrent sites in order to achieve much longer disease control.
authors.affiliation: Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Inada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Toshima
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Mori
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kondo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kishimoto
authors.forename: Takao
authors.initials: T
authors.lastname: Hiraki
authors.forename: Taihei
authors.initials: T
authors.lastname: Oshiro
authors.forename: Yukihide
authors.initials: Y
authors.lastname: Kanemitsu
authors.forename: Toshiyoshi
authors.initials: T
authors.lastname: Fujiwara
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D017115:Catheter Ablation; D003107:Colorectal Surgery; D003131:Combined Modality Therapy; D004358:Drug Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome