title: Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography.
abstract: Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is thus demonstrated in vivo.
authors.affiliation: Nizhny Novgorod State Medical Academy, 603000, Minin Square, 10/1, Nizhny Novgorod, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Kiseleva
authors.affiliation: Institute of Applied Physics RAS, 603950, Ulyanov Street, 46, Nizhny Novgorod, Russia ; N.I. Lobachevsky State University of Nizhny Novgorod, 603950, 23 Gagarin St., Nizhny Novgorod, Russia.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Kirillin
authors.affiliation: Nizhny Novgorod State Medical Academy, 603000, Minin Square, 10/1, Nizhny Novgorod, Russia.
authors.forename: Felix
authors.initials: F
authors.lastname: Feldchtein
authors.affiliation: Nizhny Novgorod State Medical Academy, 603000, Minin Square, 10/1, Nizhny Novgorod, Russia ; Department of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario M5G 2M9, Canada ; Ontario Cancer Institute, University Health Network, Toronto, Ontario M5G 2M9, Canada.
authors.forename: Alex
authors.initials: A
authors.lastname: Vitkin
authors.affiliation: Institute of Applied Physics RAS, 603950, Ulyanov Street, 46, Nizhny Novgorod, Russia ; N.I. Lobachevsky State University of Nizhny Novgorod, 603950, 23 Gagarin St., Nizhny Novgorod, Russia.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Sergeeva
authors.affiliation: Nizhny Novgorod State Medical Academy, 603000, Minin Square, 10/1, Nizhny Novgorod, Russia.
authors.forename: Elena
authors.initials: E
authors.lastname: Zagaynova
authors.affiliation: Nizhny Novgorod State Medical Academy, 603000, Minin Square, 10/1, Nizhny Novgorod, Russia.
authors.forename: Olga
authors.initials: O
authors.lastname: Streltzova
authors.affiliation: Nizhny Novgorod State Medical Academy, 603000, Minin Square, 10/1, Nizhny Novgorod, Russia.
authors.forename: Boris
authors.initials: B
authors.lastname: Shakhov
authors.affiliation: Nizhny Novgorod State Medical Academy, 603000, Minin Square, 10/1, Nizhny Novgorod, Russia.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Gubarkova
authors.affiliation: Nizhny Novgorod State Medical Academy, 603000, Minin Square, 10/1, Nizhny Novgorod, Russia.
authors.forename: Natalia
authors.initials: N
authors.lastname: Gladkova
keywords: (100.2960) Image analysis; (110.4500) Optical coherence tomography; (170.1610) Clinical applications; (170.7230) Urology; (230.5440) Polarization-selective devices; (290.5855) Scattering, polarization