title: Direct Aromatic C-H Trifluoromethylation via an Electron-Donor-Acceptor Complex.
abstract: A novel electron-donor-acceptor (EDA) complex-mediated direct C-H trifluoromethylation of arenes with Umemoto's reagent has been developed. This transformation has been enabled by an unprecedented EDA complex formed by Umemoto's reagent and an amine, which was supported by experiments and theoretical calculations. The radical-based methodology presented here allows to access highly-functionalized trifluoromethyl arenes in up to 81 % chemical yield.
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China).
authors.forename: Yuanzheng
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Institute of Theoretical and Computational Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China).
authors.forename: Xiangai
authors.initials: X
authors.lastname: Yuan
authors.affiliation: Institute of Theoretical and Computational Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China). majing@nju.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.affiliation: State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China). yushouyun@nju.edu.cn.
authors.forename: Shouyun
authors.initials: S
authors.lastname: Yu
keywords: CH functionalization; arenes; donor-acceptor systems; electron transfer; trifluoromethylation