title: Proteus mirabilis: The Enemy Within.
abstract: The organism needs to tailor the intestinal inflammatory response to pathogenic bacteria and to pathobionts that are only occasionally pathogenic. In this issue of Immunity, Seo et al. (2015) show that the pathobiont Proteus mirabilis induces NLRP3 inflammasome-dependent interleukin-1β (IL-1β) release from CCR2(+) Ly6C(high) inflammatory monocytes.
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA; Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.
authors.forename: Amiran
authors.initials: A
authors.lastname: Dzutsev
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: trinchig@mail.nih.gov.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Trinchieri
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology*; D053583:Interleukin-1beta / Q000276:immunology*; D064307:Microbiota / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D013559:Symbiosis / Q000276:immunology*
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D053583:Interleukin-1beta