title: Horizontal-guided Bone Regeneration using a Titanium Mesh and an Equine Bone Graft.
abstract: The present work describes a horizontal ridge augmentation in which a titanium mesh was preshaped by adapting it to a stereolithographic model of the patient's jaw that was fabricated from CT scans.
  
  
  
  Guided bone regeneration (GBR) involves covering the augmentation site with a long-lasting barrier to protect it from the invasion of surrounding soft tissues. Among barriers, titanium meshes may provide a successful outcome, but the intraoperatory time needed to shape them is a disadvantage.
  
  
  
  The 54-year-old patient, missing the right mandibular second bicuspid, first molar, and second molar, had her atrophic ridge augmented with a 30:70 mixture of autogenous bone and equine, enzyme-deantigenic collagen-preserved bone substitute. Two conical implants were inserted concomitantly in the second bicuspid and first molar positions, and the site was protected with the preshaped mesh. Four months later, the titanium mesh was retrieved, a bone sample was collected, and histological and histomorphometric analyses were performed. Provisional and definitive prostheses were then delivered, and follow-up controls were performed for up to 24 months.
  
  
  
  Preshaping the mesh on a model of the patient's mandible shortened the surgical time and enabled faster mesh placement. Two years after surgery, the implants were perfectly functional, and the bone width was stable over time as shown by radiographic controls. Histological analysis of the bone sample showed the heterologous biomaterial to be biocompatible and undergoing advanced remodeling and replacement with newly formed bone.
  
  
  
  Preshaping a titanium mesh over a stereolithographic model of the patient's jaw allowed for a significant reduction of the intraoperative time and may be therefore, advisable in routine practice.
authors.affiliation: Professor, Department of Dentistry, Vita e Salute San Raffaele University, Milan, Italy, Phone: 390248705703, e-mail: distefano@centrocivitali.it.
authors.forename: Danilo Alessio
authors.initials: DA
authors.lastname: Di Stefano
authors.affiliation: Private Practice, Trezzano sul Naviglio, Milan, Italy.
authors.forename: Gian Battista
authors.initials: GB
authors.lastname: Greco
authors.affiliation: Department of Neuroscience, Psychology, Drug Research and Child Health (Neurofarba), Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cinci
authors.affiliation: Department of Health Sciences, Interdepartmental Forensic Medicine Section, University of Florence, Florence, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Pieri
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000295:instrumentation*; D000818:Animals; D064592:Autografts / Q000473:pathology / Q000637:transplantation; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods*; D003094:Collagen / Q000627:therapeutic use; D017076:Computer-Aided Design; D054893:Cone-Beam Computed Tomography / Q000379:methods; D003758:Dental Implantation, Endosseous / Q000379:methods; D019094:Dental Prosthesis, Implant-Supported; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation*; D064593:Heterografts / Q000473:pathology / Q000637:transplantation*; D006736:Horses; D006801:Humans; D007576:Jaw, Edentulous, Partially / Q000534:rehabilitation / Q000601:surgery; D008336:Mandibular Diseases / Q000601:surgery*; D008875:Middle Aged; D008953:Models, Anatomic; D013526:Surgical Mesh; D014025:Titanium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D003094:Collagen; D014025:Titanium
keywords: Case report; Guided bone regeneration; Horizontal bone augmentation; Titanium mesh; Xenografts