title: Effects of aluminum chloride on serum proteins, bilirubin, and hepatic trace elements in chickens.
abstract: The aim of this study was to reveal the effects of aluminum chloride (AlCl3) on the hepatic metabolism function and trace elements' distribution. Two hundred healthy male chickens (1 day old) were intraperitoneally administered with AlCl3 (0, 18.31, 27.47, and 36.62 mg kg(-1) day(-1) of Al(3+)) consecutively for 3 days. Then the chickens were allowed to rest for 1 day. The cycle lasted four days. The cycle was repeated 15 times (60 days). The contents of serum total protein (TP), albumin (ALB), total bilirubin (TBI), direct bilirubin (DBI), hepatic aluminum (Al), copper (Cu), iron (Fe), and zinc (Zn) were examined. The results showed that the contents of serum TP and ALB and hepatic Fe and Zn decreased and the contents of serum TBI and DBI and hepatic Al and Cu increased in the chickens with AlCl3 This indicates that chronic administration of AlCl3 impairs the hepatic metabolism function and disorders the hepatic trace elements' distribution.
authors.affiliation: College of Veterinary Medicine, Jilin Science and Technology Vocational College, Jilin, China.
authors.forename: Ben
authors.initials: B
authors.lastname: Wang
authors.affiliation: Institute of Special Animal and Plant Sciences of Chinese Academy of Agricultural Sciences, Changchun, China.
authors.forename: Yanzhu
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: College of Veterinary Medicine, Jilin Science and Technology Vocational College, Jilin, China.
authors.forename: Hongling
authors.initials: H
authors.lastname: Zhang
authors.affiliation: College of Veterinary Medicine, Jilin Science and Technology Vocational College, Jilin, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Liu
authors.affiliation: College of Veterinary Medicine, Jilin Science and Technology Vocational College, Jilin, China.
authors.forename: Guojiang
authors.initials: G
authors.lastname: Li
authors.affiliation: College of Veterinary Medicine, Jilin Science and Technology Vocational College, Jilin, China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Song
authors.affiliation: College of Veterinary Medicine, Northeast Agricultural University, Harbin, China yanfeili200@126.com.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Li
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D002645:Chickens / Q000254:growth & development; D002712:Chlorides / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D011897:Random Allocation; D012709:Serum Albumin / Q000032:analysis; D014018:Tissue Distribution / Q000187:drug effects; D036401:Toxicity Tests, Chronic; D066007:Toxicokinetics; D014131:Trace Elements / Q000378:metabolism*
chemical_list: D017607:Aluminum Compounds; D001798:Blood Proteins; D002712:Chlorides; D004785:Environmental Pollutants; D012709:Serum Albumin; D014131:Trace Elements; D000077410:Aluminum Chloride; D001663:Bilirubin
keywords: Al; bilirubin; chickens; liver; protein; trace elements