title: L-Type amino acid transporter 1 (LAT1) expression in lymph node metastasis of gastric carcinoma: Its correlation with size of metastatic lesion and Ki-67 labeling.
abstract: L-Type amino acid transporter 1 (LAT1) is one of the major amino acid transporters. High levels of LAT1 expression have been reported in various tumors, which can act as a novel prognostic marker. Previously, we demonstrated that LAT1 is highly expressed in advanced gastric carcinoma with lymph node metastasis, and proposed that LAT1 is an independent prognostic factor in non-scirrhous gastric carcinoma. The aim of the present study was to investigate the relationship between LAT1 expression and the size of lymph node metastatic lesions in gastric carcinoma. LAT1 and Ki-67 expression was immunohistochemically analyzed in 64 cases of advanced gastric carcinoma with lymph node metastasis. LAT1 expression in the metastatic lymph nodes was correlated with that in the primary lesions. The high LAT1 expression group showed a larger size of metastatic lesion and a higher Ki-67 labeling index than the low LAT1 expression group. LAT1 expression had a weak association with Ki-67 labeling index and tumor diameter of lymph nodes. These results suggest that LAT1 expression is associated with disease progression in gastric carcinoma. We proposed that LAT1 could be a potential therapeutic target for gastric carcinoma cases with large lymph node metastasis.
authors.affiliation: Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan; Department of Pathology and Biological Responses, Kitasato University Graduate School of Medical Science, Sagamihara, Japan. Electronic address: hanabi@med.kitasato-u.ac.jp.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ichinoe
authors.affiliation: Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan; Department of Pathology and Biological Responses, Kitasato University Graduate School of Medical Science, Sagamihara, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Yanagisawa
authors.affiliation: Department of Pathology, Toho University School of Medicine, Tokyo, Japan.
authors.forename: Tetuo
authors.initials: T
authors.lastname: Mikami
authors.affiliation: J-Pharma, Co. Ltd., Yokohama, Japan.
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Hana
authors.affiliation: Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan; Department of Pathology and Biological Responses, Kitasato University Graduate School of Medical Science, Sagamihara, Japan.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Nakada
authors.affiliation: J-Pharma, Co. Ltd., Yokohama, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Endou
authors.affiliation: Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Okayasu
authors.affiliation: Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan; Department of Pathology and Biological Responses, Kitasato University Graduate School of Medical Science, Sagamihara, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Murakumo
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D027283:Large Neutral Amino Acid-Transporter 1 / Q000032:analysis / Q000096:biosynthesis*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D027283:Large Neutral Amino Acid-Transporter 1
keywords: Gastric carcinoma; L-type amino acid transporter 1; Lymph node metastasis