title: The RAISE Connection Program for Early Psychosis: Secondary Outcomes and Mediators and Moderators of Improvement.
abstract: The aims of this study were to explore secondary outcomes of a coordinated specialty care program for persons with early psychosis, including quality of life and recovery, as well as to explore mediators and moderators of improvement in occupational and social functioning and symptoms. Sixty-five individuals across two sites were enrolled and received services for up to 2 years. Trajectories for individuals' outcomes over time were examined using linear and quadratic mixed-effects models with repeated measures. In addition, baseline prognostic factors of participant improvement in social and occupational functioning were explored based on previous literature and expert opinion of the analytic team. Results demonstrate that the program was effective in improving quality of life and recovery over time. Furthermore, processing speed was identified as a significant moderator of improvement in occupational Global Assessment of Function, and treatment fidelity, engagement, and family involvement were identified as mediators of improvement in social and occupational functioning.
authors.affiliation: *Department of Psychiatry, Columbia University/New York State Psychiatric Institute;†Departments of Psychiatry and Biobehavioral Sciences and of Psychology, University of California, Los Angeles; and ‡Department of Psychiatry, University of Maryland School of Medicine, Baltimore.
authors.forename: Leslie
authors.initials: L
authors.lastname: Marino
authors.forename: Ilana
authors.initials: I
authors.lastname: Nossel
authors.forename: Jean C
authors.initials: JC
authors.lastname: Choi
authors.forename: Keith
authors.initials: K
authors.lastname: Nuechterlein
authors.forename: Yuanjia
authors.initials: Y
authors.lastname: Wang
authors.forename: Susan
authors.initials: S
authors.lastname: Essock
authors.forename: Melanie
authors.initials: M
authors.lastname: Bennett
authors.forename: Karen
authors.initials: K
authors.lastname: McNamara
authors.forename: Sapna
authors.initials: S
authors.lastname: Mendon
authors.forename: Lisa
authors.initials: L
authors.lastname: Dixon
mesh_terms: D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003299:Cooperative Behavior; D042241:Early Diagnosis; D061345:Early Medical Intervention; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D033183:Interdisciplinary Communication; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D017063:Outcome Assessment, Health Care; D010348:Patient Care Team; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000523:psychology / Q000534:rehabilitation*; D011788:Quality of Life / Q000523:psychology*; D012050:Rehabilitation, Vocational; D012559:Schizophrenia / Q000175:diagnosis / Q000534:rehabilitation*; D012565:Schizophrenic Psychology; D012917:Social Adjustment