title: Xylariphilone: a new azaphilone derivative from the seagrass-derived fungus Xylariales sp. PSU-ES163.
abstract: One new azaphilone derivative, named xylariphilone (1), along with 10 known compounds was isolated from the seagrass-derived fungus Xylariales sp. PSU-ES163. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute and relative configurations of 1 were determined by circular dichroism spectroscopy and NOEDIFF data. The antimicrobial and cytotoxic activities of the isolated compounds were evaluated.
authors.affiliation: a Department of Chemistry and Center of Excellence for Innovation in Chemistry , Faculty of Science, Prince of Songkla University, Hat Yai , Songkhla 90112 , Thailand.
authors.forename: Jiraporn
authors.initials: J
authors.lastname: Arunpanichlert
authors.affiliation: a Department of Chemistry and Center of Excellence for Innovation in Chemistry , Faculty of Science, Prince of Songkla University, Hat Yai , Songkhla 90112 , Thailand.
authors.forename: Vatcharin
authors.initials: V
authors.lastname: Rukachaisirikul
authors.affiliation: b Natural Products Research Center of Excellence and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai , Songkhla 90112 , Thailand.
authors.forename: Souwalak
authors.initials: S
authors.lastname: Phongpaichit
authors.affiliation: b Natural Products Research Center of Excellence and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai , Songkhla 90112 , Thailand.
authors.forename: Orathai
authors.initials: O
authors.lastname: Supaphon
authors.affiliation: c National Center for Genetic Engineering and Biotechnology (BIOTEC) , Thailand Science Park, Klong Luang, Pathumthani 12120 , Thailand.
authors.forename: Jariya
authors.initials: J
authors.lastname: Sakayaroj
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D061986:MCF-7 Cells / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010860:Pigments, Biological / Q000737:chemistry; D014709:Vero Cells / Q000187:drug effects; D013098:Xylariales / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001578:Benzopyrans; D010860:Pigments, Biological; C494154:azaphilone; C000609425:xylariphilone
keywords: Xylariales sp; antimicrobial activity; azaphilone derivative; cytotoxic activity; seagrass-derived fungus