title: Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations.
abstract: We analyzed for associations between a variable number of tandem repeat (VNTR) polymorphism in the Family with sequence similarity 46, member A (FAM46A) gene and a single nucleotide polymorphism (rs3117582) in the BCL2-Associated Athanogene 6 (BAG6) with non small cell lung cancer in Croatian and Norwegian subjects. A total of 503 (262 Croatian and 241Norwegian) non small cell lung cancer patients and 897 controls (568 Croatian and 329 Norwegian) were analyzed. We found that the frequency of allele b (three VNTR repeats) of FAM46A gene was significantly increased in the patients compared to the healthy controls in the Croatian and the combined Croatian and Norwegian subjects. Genotype frequencies of cd (four and five VNTR repeats) and cc (four VNTR repeats homozygote) of the FAM46A gene were significantly decreased in the patients compared to the healthy controls in the Croatian and Norwegian subjects, respectively. Logistic regression analyses revealed FAM46A genotype cc to be an independent predictive factor for non small cell lung cancer risk in the Norwegian subjects after adjustment for age, gender and smoking status. This is the first study to suggest an association between the FAM46A gene VNTR polymorphisms and non small cell lung cancer. We found also that BAG6 rs3117582 SNP was associated with non small cell lung cancer in the Norwegian subjects and the combined Croatian-Norwegian subjects corroborating the earlier finding that BAG6 rs3117582 SNP was associated with lung cancer in Europeans. Logistic regression analyses revealed that genotypes and alleles of BAG6 were independent predictive factor for non small cell lung cancer risk in the Norwegian and combined Croatian-Norwegian subjects, after adjustment for age and gender.
authors.affiliation: Institute for Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
authors.forename: Godfrey Essien
authors.initials: GE
authors.lastname: Etokebe
authors.affiliation: Department of Chemical and Biological Working Environment, National Institute of Occupational Health, Oslo, Norway.
authors.forename: Shanbeh
authors.initials: S
authors.lastname: Zienolddiny
authors.affiliation: Institute for Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway; Section of Pulmology, Department of Internal Medicine, Clinical Hospital Center, University of Rijeka, Rijeka, Croatia.
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Kupanovac
authors.affiliation: Institute for Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
authors.forename: Morten
authors.initials: M
authors.lastname: Enersen
authors.affiliation: Institute for Transfusion Medicine, Clinical Hospital Center, University of Rijeka, Rijeka, Croatia.
authors.forename: Sanja
authors.initials: S
authors.lastname: Balen
authors.affiliation: Section of Pulmology, Department of Internal Medicine, Clinical Hospital Center, University of Rijeka, Rijeka, Croatia.
authors.forename: Veljko
authors.initials: V
authors.lastname: Flego
authors.affiliation: Section of Pulmology, Department of Internal Medicine, Clinical Hospital Center, University of Rijeka, Rijeka, Croatia.
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Bulat-Kardum
authors.affiliation: Department for Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
authors.forename: Anđelka
authors.initials: A
authors.lastname: Radojčić-Badovinac
authors.affiliation: Department of Chemical and Biological Working Environment, National Institute of Occupational Health, Oslo, Norway.
authors.forename: Vidar
authors.initials: V
authors.lastname: Skaug
authors.affiliation: Department of Clinical Sciences, University of Bergen, Bergen, Norway.
authors.forename: Per
authors.initials: P
authors.lastname: Bakke
authors.affiliation: Department of Chemical and Biological Working Environment, National Institute of Occupational Health, Oslo, Norway.
authors.forename: Aage
authors.initials: A
authors.lastname: Haugen
authors.affiliation: Institute for Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Dembic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D017523:Croatia; D004247:DNA / Q000032:analysis; D019075:Electrophoresis, Capillary; D005260:Female; D005787:Gene Frequency; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics; D018832:Molecular Chaperones / Q000235:genetics*; D009664:Norway; D020641:Polymorphism, Single Nucleotide; D011062:Polynucleotide Adenylyltransferase; D011506:Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012907:Smoking; D044465:White People / Q000235:genetics*
chemical_list: C092009:BAG6 protein, human; D018832:Molecular Chaperones; D011506:Proteins; D004247:DNA; D011062:Polynucleotide Adenylyltransferase; C466099:TENT5A protein, human