title: Asymmetry of cerebral blood flow measured with three-dimensional pseudocontinuous arterial spin-labeling mr imaging in temporal lobe epilepsy with and without mesial temporal sclerosis.
abstract: BACKGROUND
  To investigate the asymmetry of quantitative cerebral blood flow (CBF) values in interictal temporal lobe epilepsy (TLE) patients with (TLE-MTS) and without (TLE-no) mesial temporal sclerosis.
  
  
  METHODS
  Twenty-six TLE patients (14 TLE-MTS/12 TLE-no) and 22 controls were studied with a three-dimensional whole-brain pseudocontinuous arterial spin-labeling technique at 3.0 Tesla. Regions of interest were placed at the bilateral hippocampal heads, amygdalas and temporal lobes to get the average regional cerebral blood flow (rCBF) and calculate asymmetry indices (AIs). Statistical parametric mapping detected the whole-brain CBF changes of the two subgroups (right-sided).
  
  
  RESULTS
  AIs of the hippocampus and amygdala in TLE-MTS and AIs of hippocampus in TLE-no were significantly different versus controls (P < 0.001, P = 0.001, and P = 0.013). The lateralizing sensitivity increased to 96.154% by combining structural MRI and AIs of rCBF with optimal cutoff values. Hypoperfusion regions in the right TLE-MTS mainly clustered in the bilateral temporal lobes, frontal lobes, insular lobes, and left caudate nucleus. The right TLE-no showed hypoperfusion in the bilateral temporal lobes, frontal lobes, right insular lobe, parietal lobe, occipital lobe, and caudate nucleus.
  
  
  CONCLUSIONS
  Asymmetry of CBF in the TLE-MTS and TLE-no is different and improves MRI performance in lateralizing the TLE.
authors.affiliation: Shandong Medical Imaging Research Institute, Shandong University, Jinan, People's Republic of China.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital, Jinan, People's Republic of China.
authors.forename: Shangchen
authors.initials: S
authors.lastname: Xu
authors.affiliation: Shandong Medical Imaging Research Institute, Shandong University, Jinan, People's Republic of China.
authors.forename: Guangbin
authors.initials: G
authors.lastname: Wang
authors.affiliation: Shandong Medical Imaging Research Institute, Shandong University, Jinan, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Shandong Medical Imaging Research Institute, Shandong University, Jinan, People's Republic of China.
authors.forename: Lingfei
authors.initials: L
authors.lastname: Guo
authors.affiliation: Shandong Medical Imaging Research Institute, Shandong University, Jinan, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012598:Sclerosis / Q000473:pathology / Q000503:physiopathology; D012720:Severity of Illness Index; D013113:Spin Labels; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult
chemical_list: D013113:Spin Labels
keywords: ASL; CBF; amygdala; hippocampus; mesial temporal sclerosis; temporal lobe epilepsy