title: Engineering the nanoparticle-protein interface for cancer therapeutics.
abstract: Intracellular delivery of functional proteins using nanoparticles can be a game-changing approach for cancer therapy. However, cytosolic release of functional protein is still a major challenge. In addition, formation of protein corona on the surface of the nanoparticles can also alter the behavior of the nanoparticles. Here, we will review recent strategies for protein delivery into the cell. Finally we will discuss the issue of protein corona formation in light of nanoparticle-protein interactions.
authors.affiliation: Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Amir Ata
authors.initials: AA
authors.lastname: Saie
authors.forename: Moumita
authors.initials: M
authors.lastname: Ray
authors.forename: Morteza
authors.initials: M
authors.lastname: Mahmoudi
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D058726:Nanoconjugates / Q000627:therapeutic use*; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D058726:Nanoconjugates