title: Assessing the level of chromosome aberrations in peripheral blood lymphocytes in long-term resident children under conditions of high exposure to radon and its decay products.
abstract: In this study, the frequency and spectrum of chromosomal aberrations were analysed in samples of peripheral blood from 372 (mean age = 12.24 ± 2.60 years old) long-term resident children in a boarding school (Tashtagol city, Kemerovo Region, Russian Federation) under conditions of high exposure to radon and its decay products. As a control group, we used blood samples from people living in Zarubino village (Kemerovo Region, Russian Federation). We discovered that the average frequencies of single and double fragments, chromosomal exchanges, total number of aberrations, chromatid type, chromosome type and all types of aberrations were significantly increased in the exposed group. This is evidence of considerable genotoxicity to children living under conditions of high exposure to radon compared to children living under ecological conditions without increased radon radiation.
authors.affiliation: Department of Genetics, Biology Faculty, Kemerovo State University, Krasnaya St. 6, Kemerovo 650043, Russian Federation and Institute of Human Ecology of SB RAS, Leningradsky Ave 10, Kemerovo 650065, Russian Federation.
authors.forename: Vladimir G
authors.initials: VG
authors.lastname: Druzhinin
authors.affiliation: Department of Genetics, Biology Faculty, Kemerovo State University, Krasnaya St. 6, Kemerovo 650043, Russian Federation and sinitsky.maxim@gmail.com.
authors.forename: Maxim Yu
authors.initials: MY
authors.lastname: Sinitsky
authors.affiliation: Department of Genetics, Biology Faculty, Kemerovo State University, Krasnaya St. 6, Kemerovo 650043, Russian Federation and.
authors.forename: Aleksey V
authors.initials: AV
authors.lastname: Larionov
authors.affiliation: Department of Genetics, Biology Faculty, Kemerovo State University, Krasnaya St. 6, Kemerovo 650043, Russian Federation and.
authors.forename: Valentin P
authors.initials: VP
authors.lastname: Volobaev
authors.affiliation: Institute of Human Ecology of SB RAS, Leningradsky Ave 10, Kemerovo 650065, Russian Federation.
authors.forename: Varvara I
authors.initials: VI
authors.lastname: Minina
authors.affiliation: Department of Genetics, Biology Faculty, Kemerovo State University, Krasnaya St. 6, Kemerovo 650043, Russian Federation and.
authors.forename: Tatiana A
authors.initials: TA
authors.lastname: Golovina
mesh_terms: D000293:Adolescent; D002648:Child; D002869:Chromosome Aberrations / Q000528:radiation effects*; D004247:DNA / Q000528:radiation effects; D004249:DNA Damage; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D000069079:Radiation Exposure; D011851:Radioactivity; D011886:Radon / Q000633:toxicity*; D012426:Russia; D055815:Young Adult
chemical_list: D004247:DNA; D011886:Radon