title: Effect of the -148C/T, 448G/A, and -854G/A Polymorphisms of the β-Fibrinogen Gene on the Risk of Ischemic Stroke in Chinese Population.
abstract: BACKGROUND
  Several investigations have been performed to examine the influence of the β-fibrinogen (FGβ) gene polymorphisms on the risk of ischemic stroke, but the results of these studies are controversial. Our study aimed at investigating whether the FGβ gene (-148 C/T, 448 G/A, and -854 G/A) polymorphisms were associated with susceptibility to ischemic stroke by conducting meta-analysis.
  
  
  METHODS
  Relevant studies were identified from 4 Chinese databases, PUBMED and EMBASE before May 30, 2014. The strength of association was evaluated by the odds ratio with 95% confidence interval. Inconsistency index and the Cochran's Q statistic were used to check heterogeneity. Publication bias was tested using funnel plots and Egger's regression test.
  
  
  RESULTS
  Thirty-two independent studies with 4311 cases and 4124 controls were included. Significant association between -148 C/T polymorphism and the risk of ischemic stroke was found in overall analysis and middle-age, but not in young adults and elderly people. Similarly, association was also observed for -854 G/A polymorphism, especially in cerebral arterial main trunk infarction (MCI) and cerebral penetrating arterial infarction (PCI). However, no significance was found between 448 G/A polymorphism and ischemic stroke in Chinese people; likewise, no evidence of a significant association was observed when stratified according to the subtype of ischemic stroke (MCI and PCI).
  
  
  CONCLUSIONS
  These results suggest that -148 C/T and -854 G/A polymorphisms probably contribute to susceptibility of ischemic stroke.
authors.affiliation: Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Wu
authors.affiliation: Guangxi University of Chinese Medicine, Nanning, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Cai
authors.affiliation: Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Haobin
authors.initials: H
authors.lastname: Cai
authors.affiliation: Guangxi University of Chinese Medicine, Nanning, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Guangxi University of Chinese Medicine, Nanning, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tan
authors.affiliation: Zhuhai Hospital of Guangdong Provincial Traditional Chinese Medical Hospital, Guangzhou University of Chinese Medicine, Zhuhai, China.
authors.forename: Huitao
authors.initials: H
authors.lastname: Qi
authors.affiliation: Department of Internal Neurology, Guangdong Provincial Traditional Chinese Medicine Hospital, Guangzhou, China. Electronic address: caiyfengtg@163.com.
authors.forename: Yefeng
authors.initials: Y
authors.lastname: Cai
mesh_terms: D044466:Asian People / Q000235:genetics*; D002545:Brain Ischemia / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005340:Fibrinogen / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*
chemical_list: C000592498:FGB protein, human; D005340:Fibrinogen
keywords: -148C/T; -854G/A; 448G/A; ischemic stroke; polymorphism; β-Fibrinogen