title: Pathways Mediating Activity-Induced Enhancement of Recovery From Peripheral Nerve Injury.
abstract: This article outlines the novel hypothesis that exercise promotes axon regeneration after peripheral nerve injury through neuronal brain-derived neurotrophic factor (BDNF), and there are three required means of promoting BDNF expression: 1) increased signaling through androgen receptors, 2) increased cAMP-responsive element-binding protein expression, and 3) increased expression of the transcription factor SRY-box containing gene 11.
authors.affiliation: 1Departments of Rehabilitation Medicine and 2Cell Biology, Emory University School of Medicine, Atlanta, GA.
authors.forename: Manning J
authors.initials: MJ
authors.lastname: Sabatier
authors.forename: Arthur W
authors.initials: AW
authors.lastname: English
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D059348:Peripheral Nerve Injuries / Q000503:physiopathology*; D011944:Receptors, Androgen / Q000378:metabolism; D055751:SOXC Transcription Factors / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D017362:Cyclic AMP Response Element-Binding Protein; D011944:Receptors, Androgen; D055751:SOXC Transcription Factors; C490793:Sox11 protein, mouse; C579455:BDNF protein, human