title: HIV-associated memory B cell perturbations.
abstract: Memory B-cell depletion, hyperimmunoglobulinemia, and impaired vaccine responses are the hallmark of B cell perturbations inhuman immunodeficiency virus (HIV) disease. Although B cells are not the targets for HIV infection, there is evidence for B cell, especially memory B cell dysfunction in HIV disease mediated by other cells or HIV itself. This review will focus on HIV-associated phenotypic and functional alterations in memory B cells. Additionally, we will discuss the mechanism underlying these perturbations and the effect of anti-retroviral therapy (ART) on these perturbations.
authors.affiliation: Department of Infectious Disease, the Second Affiliated Hospital of the Southeast University, Nanjing 210003, China; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Zhenwu
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Wan
authors.affiliation: Beijing You'an Hospital, Capital Medical University, No. 8 Xitoutiao, You'an men wai, Fengtai District, Beijing 100069, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Beijing You'an Hospital, Capital Medical University, No. 8 Xitoutiao, You'an men wai, Fengtai District, Beijing 100069, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Beijing You'an Hospital, Capital Medical University, No. 8 Xitoutiao, You'an men wai, Fengtai District, Beijing 100069, China. Electronic address: drtong.zhang@gmail.com.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA; Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address: jianw@musc.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000473:pathology; D002470:Cell Survival; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D014612:Vaccines / Q000276:immunology
chemical_list: D014612:Vaccines
keywords: Anti-retroviral therapy; HIV; Memory B cells; Vaccination