title: Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye.
abstract: Retinal vascular diseases are important causes of vision loss. A detailed evaluation of the vascular abnormalities facilitates diagnosis and treatment in these diseases. Optical coherence tomography (OCT) angiography using the highly efficient split-spectrum amplitude decorrelation angiography algorithm offers an alternative to conventional dye-based retinal angiography. OCT angiography has several advantages, including 3D visualization of retinal and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related complications. Results from six illustrative cases are reported. In diabetic retinopathy, OCT angiography can detect neovascularization and quantify ischemia. In age-related macular degeneration, choroidal neovascularization can be observed without the obscuration of details caused by dye leakage in conventional angiography. Choriocapillaris dysfunction can be detected in the nonneovascular form of the disease, furthering our understanding of pathogenesis. In choroideremia, OCT's ability to show choroidal and retinal vascular dysfunction separately may be valuable in predicting progression and assessing treatment response. OCT angiography shows promise as a noninvasive alternative to dye-based angiography for highly detailed, in vivo, 3D, quantitative evaluation of retinal vascular abnormalities.
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239;
authors.forename: Yali
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239;
authors.forename: Steven T
authors.initials: ST
authors.lastname: Bailey
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239;
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Hwang
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239;
authors.forename: Scott M
authors.initials: SM
authors.lastname: McClintic
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239;
authors.forename: Simon S
authors.identifier: http://orcid.org/0000-0002-7020-037X
authors.initials: SS
authors.lastname: Gao
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239;
authors.forename: Mark E
authors.initials: ME
authors.lastname: Pennesi
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239;
authors.forename: Christina J
authors.initials: CJ
authors.lastname: Flaxel
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239;
authors.forename: Andreas K
authors.initials: AK
authors.lastname: Lauer
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239;
authors.forename: David J
authors.initials: DJ
authors.lastname: Wilson
authors.affiliation: Pattern Recognition Lab and School of Advanced Optical Technologies, University Erlangen-Nuremberg, D-91058 Erlangen, Germany; and.
authors.forename: Joachim
authors.initials: J
authors.lastname: Hornegger
authors.affiliation: Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139.
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
authors.affiliation: Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239; huangd@ohsu.edu.
authors.forename: David
authors.initials: D
authors.lastname: Huang
mesh_terms: D000465:Algorithms; D049109:Cell Proliferation; D002829:Choroid / Q000098:blood supply; D020256:Choroidal Neovascularization / Q000473:pathology; D015794:Choroideremia / Q000473:pathology; D003930:Diabetic Retinopathy / Q000473:pathology; D005128:Eye Diseases / Q000175:diagnosis* / Q000503:physiopathology; D005451:Fluorescein Angiography / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry; D005654:Fundus Oculi; D006801:Humans; D008268:Macular Degeneration / Q000473:pathology; D010477:Perfusion; D012171:Retinal Vessels / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods*; D014652:Vascular Diseases / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D005456:Fluorescent Dyes
keywords: ocular circulation; ophthalmic imaging; optical coherence tomography angiography