title: Drug-coated balloon and stent therapies for endovascular treatment of atherosclerotic superficial femoral artery disease.
abstract: Endovascular management of superficial femoral artery disease has historically been limited to percutaneous balloon angioplasty, atherectomy, and bare-metal stents. However, these therapies have been plagued by high restenosis and target lesion revascularization rates. More recent technologies such as drug-coated stents and balloons are designed to combat restenosis by locally delivering antiproliferative drugs. Several randomized controlled trials have directly compared these antiproliferative drug-delivering devices to their non-drug-coated counterparts. Additionally, trials are currently ongoing to compare use of drug-coated technologies in combination with traditional therapies in hope of synergistic effects. This review gathers data from currently published clinical trials, provides an overview of upcoming clinical studies utilizing drug-coated technology, and explores the possible impact these devices may have on clinical practice.
authors.affiliation: Veteran Affairs North Texas Healthcare System, 4500 S Lancaster Road (111A), Dallas, TX, 75216, USA, subhash.banerjee@va.gov.
authors.forename: Subhash
authors.initials: S
authors.lastname: Banerjee
authors.forename: Karan
authors.initials: K
authors.lastname: Sarode
authors.forename: Atif
authors.initials: A
authors.lastname: Mohammad
authors.forename: Emmanouil S
authors.initials: ES
authors.lastname: Brilakis
mesh_terms: D000800:Angioplasty, Balloon; D002317:Cardiovascular Agents / Q000008:administration & dosage* / Q000145:classification; D054855:Drug-Eluting Stents; D005263:Femoral Artery / Q000601:surgery*; D006801:Humans; D035002:Lower Extremity; D058729:Peripheral Arterial Disease / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic
chemical_list: D002317:Cardiovascular Agents