title: Two new conjugated ketonic fatty acids from the stem bark of Juglans mandshurica.
abstract: The present study was designed to isolate and characterize novel chemical constituents of the stem bark of Juglans mandshurica Maxim. (Juglandaceae). The chemical constituents were isolated and purified by various chromatographic techniques. The structures of the compounds were elucidated on the basis of spectral data (1D and 2D NMR, HR-ESI-MS, CD, UV, and IR) and by the comparisons of spectroscopic data with the reported values in the literatures. Two long chain polyunsaturated fatty acids (1 and 2) were obtained and identified as (S)-(8E,10E)-12-hydroxy-7-oxo-8,10-octadecadienoic acid (1) and (S)-(8E, 10E)-12-hydroxy-7-oxo-8,10-octadecadienoic acid methyl ester (2). To the best of our knowledge, this is the first report on the isolation and structural elucidation of the two new conjugated ketonic fatty acids from this genus.
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
authors.forename: Da-Lei
authors.initials: DL
authors.lastname: Yao
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
authors.forename: Chang-Hao
authors.initials: CH
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, Yanbian University Hospital, Yanji 133000, China.
authors.forename: Ren
authors.initials: R
authors.lastname: Li
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China; Department of Pharmacy, Yanbian University Hospital, Yanji 133000, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Piao
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
authors.forename: Ming-Shan
authors.initials: MS
authors.lastname: Zheng
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.
authors.forename: Jiong-Mo
authors.initials: JM
authors.lastname: Cui
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan 712-749, Korea.
authors.forename: Jong Keun
authors.initials: JK
authors.lastname: Son
authors.affiliation: Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China. Electronic address: gli@ybu.edu.cn.
authors.forename: Gao
authors.initials: G
authors.lastname: Li
mesh_terms: D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification*; D031324:Juglans / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: C000604046:(S)-(8E,10E)-12-hydroxy-7-oxo-8,10-octadecadienoic acid; C000604048:(S)-(8E,10E)-12-hydroxy-7-oxo-8,10-octadecadienoic acid methyl ester; D005231:Fatty Acids, Unsaturated
keywords: Conjugated ketonic fatty acid; Juglandaceae; Juglans mandshurica