title: Superparamagnetic iron oxide nanoparticles for in vivo molecular and cellular imaging.
abstract: In the last decade, the biomedical applications of nanoparticles (NPs) (e.g. cell tracking, biosensing, magnetic resonance imaging (MRI), targeted drug delivery, and tissue engineering) have been increasingly developed. Among the various NP types, superparamagnetic iron oxide NPs (SPIONs) have attracted considerable attention for early detection of diseases due to their specific physicochemical properties and their molecular imaging capabilities. A comprehensive review is presented on the recent advances in the development of in vitro and in vivo SPION applications for molecular imaging, along with opportunities and challenges.
authors.affiliation: Department of Biomaterials Science and Technology, University of Twente, The Netherlands.
authors.forename: Shahriar
authors.initials: S
authors.lastname: Sharifi
authors.affiliation: Department of Bioengineering, Rice University, Houston, TX, 77005, USA.
authors.forename: Hajar
authors.initials: H
authors.lastname: Seyednejad
authors.affiliation: Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau 19, B-7000, Mons, Belgium.|CMMI - Center for Microscopy and Molecular Imaging, Rue Adrienne Bolland 8, B-6041, Gosselies, Belgium.
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.affiliation: Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Atyabi
authors.affiliation: Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.|Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Amir Ata
authors.initials: AA
authors.lastname: Saei
authors.affiliation: Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.|Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.|Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
authors.forename: Morteza
authors.initials: M
authors.lastname: Mahmoudi
mesh_terms: D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide
keywords: MRI; SPIONs; cellular imaging; iron oxide; molecular imaging; superparamagnetic nanoparticles