title: [Study on molecular mechanism of Euodiae Fructus on liver toxicity in MICE].
abstract: OBJECTIVE
  To study the molecular mechanism of extracts from Euodia rutaecarpa on hepatotoxicity in mice.
  
  
  METHODS
  Totally 30 KM mice were divided into 3 groups and orally administrated extracts from E. rutaecarpa for consecutively 15 days. The expressions of Erkl/2, CDK8, CK1e, Stat3 and Src were detected by Western blotting method.
  
  
  RESULTS
  The extracts from E. rutaecarpa could up-regulated Erkl/2, CDK8 and CK1e expressions (P <0.01) and down-regulate Stat3 and Src (P <0.01).
  
  
  CONCLUSIONS
  The molecular mechanism of E. rutaecarpa on hepatotoxicity may be correlated with Erkl/2, CDK8, CKle, Stat3 and Src signal molecules.
authors.forename: Wen-qiang
authors.initials: WQ
authors.lastname: Liao
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Jun-ning
authors.initials: JN
authors.lastname: Zhao
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015536:Down-Regulation; D004365:Drugs, Chinese Herbal / Q000633:toxicity*; D032086:Evodia / Q000737:chemistry*; D005260:Female; D005638:Fruit / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D010946:Plants, Medicinal; D015398:Signal Transduction / Q000187:drug effects*; D013047:Specific Pathogen-Free Organisms; D014280:Triglycerides / Q000097:blood; D015854:Up-Regulation
chemical_list: D004365:Drugs, Chinese Herbal; D014280:Triglycerides; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase