title: Analysis of 65 pregnancies in 34 women with five different forms of inherited platelet function disorders.
abstract: This study evaluated 65 pregnancies in 34 women with five different inherited platelet function disorders. Gestation was similar to that of the general population. Severe bleeds requiring blood transfusions were observed in 50% of deliveries in Glanzmann thrombasthenia (GT), but not in the patients with delta storage pool disease, Hermansky-Pudlak syndrome, P2Y12 defect or defect of thromboxane A2 receptor. Of note, severe haemorrhage also occurred in women with GT who had received prophylactic platelet transfusions, suggesting that better preventive treatments are required. Diagnosis and degree of spontaneous bleeding tendency before pregnancy were reliable parameters to predict the delivery-related bleeding risk.
authors.affiliation: Department of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
authors.forename: Elisa
authors.initials: E
authors.lastname: Civaschi
authors.affiliation: Service of Biometry & Statistics, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.affiliation: Department of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Melazzini
authors.affiliation: Universitat Autònoma de Barcelona & Institut de Recerca Biomèdica Sant Pau, Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Pujol-Moix
authors.affiliation: Ematologia, Policlinico Umberto 1, Università Sapienza, Rome, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Santoro
authors.affiliation: Dipartimento di Scienze della Salute, Medicina III, Ospedale San Paolo, Università degli Studi di Milano, Milano, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Cattaneo
authors.affiliation: AP-HP, Hôpital Bicêtre, Hématologie Biologique/Centre de Référence Pathologies Plaquettaires, Le Kremlin Bicêtre, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Lavenu-Bombled
authors.affiliation: Department of Medicine, University of Perugia, Perugia, Italy.
authors.forename: Loredana
authors.initials: L
authors.lastname: Bury
authors.affiliation: Department of Medicine, University of Verona, Verona, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Minuz
authors.affiliation: Plateforme Technologique et d'Innovation Biomédicale, Hôpital Xavier Arnozan, Pessac, France.
authors.forename: Paquita
authors.initials: P
authors.lastname: Nurden
authors.affiliation: Unidad de Hemostasia y Trombosis, La Fe University Hospital, Valencia, Spain.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Cid
authors.affiliation: Department of Medicine and Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Cuker
authors.affiliation: Centre de Compétence Nord-Est des Pathologies Plaquettaires from the Frame of the Reference French Centre and Service d'Hématologie Biologique, Centre Hospitalo-Universitaire, Nancy, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Latger-Cannard
authors.affiliation: Haematological Laboratory, AP-HP, Armand Trousseau Children Hospital, French Reference Centre for Inherited Platelet Disorders, Paris, France.|Inserm U1170, Villejuif, France.
authors.forename: Remi
authors.initials: R
authors.lastname: Favier
authors.affiliation: Department of Cell Therapy and Haematology, San Bortolo Hospital, Vicenza, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Nichele
authors.affiliation: Department of Internal Medicine, University of Pavia-IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Noris
mesh_terms: D000293:Adolescent; D000328:Adult; D001791:Blood Platelet Disorders / Q000628:therapy*; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D008875:Middle Aged; D017713:Platelet Transfusion; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*
keywords: bleeding diathesis; bleeding risk; inherited platelet disorders; perinatal haemostasis; pregnancy