title: [Role of polymorphism NO-synthase gene in the pathogenesis of multifactorial diseases].
abstract: The review of the literature about the results of the study of the role of 4a/b VNTR-polymorphism of eNOS in pathophysiology of various states of the body. It is shown that the data are ambiguous and sometimes contradictory. The study of the contribution of candidate genes to the implementation of multifactorial diseases can increase the accuracy of prediction of the set of risk factors, early diagnosis facilitate and sufficient therapy of multifactorial diseases.
authors.forename: E I
authors.initials: EI
authors.lastname: Stepanova
authors.forename: E A
authors.initials: EA
authors.lastname: Skvarskaia
mesh_terms: D000483:Alleles; D001249:Asthma / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D003920:Diabetes Mellitus / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D015870:Gene Expression; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D024821:Metabolic Syndrome / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D018598:Minisatellite Repeats; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D052250:Nitric Oxide Synthase Type III / Q000235:genetics* / Q000378:metabolism; D010807:Physical Endurance / Q000235:genetics; D011110:Polymorphism, Genetic; D012307:Risk Factors; D018805:Sepsis / Q000201:enzymology / Q000235:genetics / Q000473:pathology
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III