title: Cytoprotective and anti-inflammatory effects of kernel extract from Adenanthera pavonina on lipopolysaccharide-stimulated rat peritoneal macrophages.
abstract: OBJECTIVE
  To investigate mechanism of anti-inflammatory activity of Adenanthera pavonina (A. pavonina) extracts.
  
  
  METHODS
  Rat peritoneal macrophages were treated with different concentrations of lipopolysaccharide and H2O2 in the presence and absence of kernel extract from A. pavonina. Nitric oxide, Superoxide anion generation, cell viability and nuclear fragmentation were investigated.
  
  
  RESULTS
  The pre-treatment of kernel extract from A. pavonina suppressed nitric oxide, superoxide anion, cell death, nuclear fragmentation in lipopolysaccharide and H2O2 stimulated or induced macrophages, respectively.
  
  
  CONCLUSIONS
  These results suggest that A. pavonina extract suppresses the intra cellular peroxide production.
authors.affiliation: Department of Biotechnology, Sri Sankara Arts and Science College, Enathur, Kanchipuram-631 561, Tamilnadu, India. Electronic address: akoodalingam@gmail.com.
authors.forename: Arunagirinathan
authors.initials: A
authors.lastname: Koodalingam
authors.affiliation: Department of Animal Health and Management, Alagappa University, Karaikudi-630 003, Tamilnadu, India.
authors.forename: Ramar
authors.initials: R
authors.lastname: Manikandan
authors.affiliation: Department of Biotechnology, Sri Sankara Arts and Science College, Enathur, Kanchipuram-631 561, Tamilnadu, India.
authors.forename: Munisamy
authors.initials: M
authors.lastname: Indhumathi
authors.affiliation: Department of Biotechnology, Sri Sankara Arts and Science College, Enathur, Kanchipuram-631 561, Tamilnadu, India.
authors.forename: Ethala Subramani
authors.initials: ES
authors.lastname: Kaviya
keywords: Cytoprotective effect; Cytotoxicity; Inflammation; Macrophage; Nitric oxide