title: Limited value of long-term biochemical follow-up in patients with adrenal incidentalomas-a retrospective cohort study.
abstract: BACKGROUND
  The prevailing view that advocates long-term hormonal follow-up of adrenal incidentalomas is currently under debate. The purpose of the present study was to examine all adrenal incidentalomas presented during five years to a single centre. We hypothesized that 24-month biochemical follow-up in patients with an initial normal screening would fail to increase the sensitivity in finding hormone producing tumours.
  
  
  METHODS
  The present study is a retrospective register based cohort study of 194 patients referred to the Department of Endocrinology at Södersjukhuset between the years 2006-2010. Computerized medical records were used to find and extract information on patients with newly discovered adrenal incidentalomas. The sensitivity, specificity, positive predictive value and negative predictive value were calculated to evaluate the validity of an initial normal screening when used to identify individuals with hormone producing tumours.
  
  
  RESULTS
  Of the incidentalomas 94% consisted of benign, non-functioning tumours. Three patients were diagnosed with cortisol hypersecretion and one with pheochromocytoma. The sensitivity, specificity, positive predictive value and negative predictive value of an initial complete negative screening to predict a hormone producing tumour were 100%, 63%, 12% and 100%, respectively.
  
  
  CONCLUSIONS
  Patients with an initially normal hormonal screening may not need further biochemical follow-up.
authors.affiliation: Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, SE 118 82, Stockholm, Sweden. hannah.yeomans@gmail.com.
authors.forename: Hannah
authors.initials: H
authors.lastname: Yeomans
authors.affiliation: Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, SE 118 82, Stockholm, Sweden. jan.calissendorff@sodersjukhuset.se.
authors.forename: Jan
authors.initials: J
authors.lastname: Calissendorff
authors.affiliation: Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, SE 118 82, Stockholm, Sweden. cristina.dahlqvist-volpe@sodersjukhuset.se.
authors.forename: Cristina
authors.initials: C
authors.lastname: Volpe
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, SE 171 76, Stockholm, Sweden. henrik.falhammar@ki.se.|Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, D2:04, SE 171 76, Stockholm, Sweden. henrik.falhammar@ki.se.
authors.forename: Henrik
authors.initials: H
authors.lastname: Falhammar
authors.affiliation: Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, SE 118 82, Stockholm, Sweden. buster.mannheimer@sodersjukhuset.se.
authors.forename: Buster
authors.initials: B
authors.lastname: Mannheimer
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D000368:Aged; D015415:Biomarkers / Q000032:analysis* / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D018447:Medical Futility; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D010673:Pheochromocytoma / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers