title: RAI thyroid bed uptake after total thyroidectomy: A novel SPECT-CT anatomic classification system.
abstract: OBJECTIVE
  Recent, more selective use of radioactive iodine (RAI) has led to reevaluation of the clinical importance of achieving complete total thyroidectomy with minimal residual normal thyroid tissue. We utilize the improved localization by post-RAI remnant ablation, single photon emission computerized tomography-computed tomography (SPECT-CT) to define specific anatomic sites of residual RAI-uptake foci after total thyroidectomy for differentiated thyroid cancer (DTC) and to provide a novel classification system relating uptake to thyroid anatomy and preservation of adjacent neural structures.
  
  
  METHODS
  Retrospective.
  
  
  METHODS
  Radioactive iodine-uptake foci in thyroid bed were localized by SPECT/CT imaging at the time of RAI remnant ablation in 141 DTC patients undergoing total thyroidectomy.
  
  
  RESULTS
  Minimal residual RAI uptake (median 0.32% at 24 hours) in the thyroid bed was detected by diagnostic planar whole body scans in 93% and by posttherapy SPECT/CT imaging in 99% of subjects. Discrete RAI uptake foci were identified on the SPECT/CT imaging at Berry's ligament (87%), at superior thyroid poles (79%), in paratracheal-lobar regions (67%), in isthmus-region (54%), and in pyramidal lobe (46%). Despite the residual foci, the nonstimulated thyroglobulin (Tg) prior to remnant ablation (with a median thyroid-stimulating hormone of 0.36 m IU/L) was < 0.6 ng/mL in 53% and < 1 ng/mL in 73% of cases.
  
  
  CONCLUSIONS
  After extracapsular total thyroidectomy, highly sensitive detection tools identify microscopic residual RAI avid foci in thyroid bed in the majority of patients. These foci can be classified as 1) neural-related and 2) capsule-related. These common residual foci have no relationship to postoperative Tg, suggesting that attempts at radical removal of thyroid tissue in these locations may not be warranted.
  
  
  METHODS
  4.
authors.affiliation: Department of Endocrinology Service, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Zeuren
authors.affiliation: Department of Endocrinology Service, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: Agnese
authors.initials: A
authors.lastname: Biagini
authors.affiliation: Department of Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: Ravinder K
authors.initials: RK
authors.lastname: Grewal
authors.affiliation: Division of Thyroid and Parathyroid Surgery, Otolaryngology, Massachusetts Eye and Ear Infirmary.|Department of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Randolph
authors.affiliation: Division of Thyroid and Parathyroid Surgery, Otolaryngology, Massachusetts Eye and Ear Infirmary.
authors.forename: Dipti
authors.initials: D
authors.lastname: Kamani
authors.affiliation: Department of Endocrinology Service, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: Mona M
authors.initials: MM
authors.lastname: Sabra
authors.affiliation: Department of Endocrinology Service, Memorial Sloan-Kettering Cancer Center, New York, New York.|Department of Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: Ashok R
authors.initials: AR
authors.lastname: Shaha
authors.affiliation: Department of Endocrinology Service, Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: R Michael
authors.initials: RM
authors.lastname: Tuttle
mesh_terms: D055011:Ablation Techniques; D000328:Adult; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013961:Thyroid Gland / Q000000981:diagnostic imaging* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D013965:Thyroidectomy; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D007457:Iodine Radioisotopes
keywords: RRA; postoperative Tg; radioactive iodine; remnant ablation; thyroid cancer; thyroidectomy