title: Comparison of digital breast tomosynthesis and 2D digital mammography using a hybrid performance test.
abstract: This paper introduces a hybrid method for performing detection studies in projection image based modalities, based on image acquisitions of target objects and patients. The method was used to compare 2D mammography and digital breast tomosynthesis (DBT) in terms of the detection performance of spherical densities and microcalcifications. The method starts with the acquisition of spheres of different glandular equivalent densities and microcalcifications of different sizes immersed in a homogeneous breast tissue simulating medium. These target objects are then segmented and the subsequent templates are fused in projection images of patients and processed or reconstructed. This results in hybrid images with true mammographic anatomy and clinically relevant target objects, ready for use in observer studies. The detection study of spherical densities used 108 normal and 178 hybrid 2D and DBT images; 156 normal and 321 hybrid images were used for the microcalcifications. Seven observers scored the presence/absence of the spheres/microcalcifications in a square region via a 5-point confidence rating scale. Detection performance in 2D and DBT was compared via ROC analysis with sub-analyses for the density of the spheres, microcalcification size, breast thickness and z-position. The study was performed on a Siemens Inspiration tomosynthesis system using patient acquisitions with an average age of 58 years and an average breast thickness of 53 mm providing mean glandular doses of 1.06 mGy (2D) and 2.39 mGy (DBT). Study results showed that breast tomosynthesis (AUC = 0.973) outperformed 2D (AUC = 0.831) for the detection of spheres (p  <  0.0001) and this applied for all spherical densities and breast thicknesses. By way of contrast, DBT was worse than 2D for microcalcification detection (AUC2D = 0.974, AUCDBT = 0.838, p  <  0.0001), with significant differences found for all sizes (150-354 µm), for breast thicknesses above 40 mm and for heights above the detector of 20 mm and above. In conclusion, the hybrid method was successfully used to produce images for a detection study; results showed breast tomosynthesis outperformed 2D for spherical densities while further optimization of DBT for microcalcifications is suggested.
authors.affiliation: Department of Imaging and Pathology, Division of Medical Physics & Quality Assessment, KU Leuven, Herestraat 49 Box 7003, 3000 Leuven, Belgium. Department of Radiology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
authors.forename: Lesley
authors.initials: L
authors.lastname: Cockmartin
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Marshall
authors.forename: Chantal
authors.initials: C
authors.lastname: Van Ongeval
authors.forename: Gwen
authors.initials: G
authors.lastname: Aerts
authors.forename: Davina
authors.initials: D
authors.lastname: Stalmans
authors.forename: Federica
authors.initials: F
authors.lastname: Zanca
authors.forename: Eman
authors.initials: E
authors.lastname: Shaheen
authors.forename: Frederik
authors.initials: F
authors.lastname: De Keyzer
authors.forename: David R
authors.initials: DR
authors.lastname: Dance
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Young
authors.forename: Hilde
authors.initials: H
authors.lastname: Bosmans
mesh_terms: D001941:Breast Diseases / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D012372:ROC Curve; D011856:Radiographic Image Enhancement / Q000379:methods*; D014056:Tomography, X-Ray / Q000379:methods*