title: Epidermal growth factor receptor gene mutations in patients with lung adenocarcinoma differ by frequency and type between Uighur and Han ethnic groups in Xinjiang Autonomous Region.
abstract: BACKGROUND
  This study was designed to investigate epidermal growth factor receptor (EGFR) mutation types affecting lung cancer treatment in patients in Xinjiang, China. We detected and analyzed differences in the EGFR mutation points of Uighur and Han patients with lung adenocarcinoma. We examined 181 specimens of lung adenocarcinoma tissue embedded with paraffin (76 Uighur and 105 Han patients) for mutations in the EGFR gene in exon 18-21 by the amplification refractory mutation system (ARMS) method. We used the chi-square statistical method to analyze the relationship between mutations and patients' clinical parameters.
  
  
  RESULTS
  EGFR somatic mutations were detected in 59 of 181 cases (32.6%). The mutation rate was higher in Han patients (45.7%) than in Uighur patients (15.8%) (P < 0.001). The main mutation types were the exon 19 deletion and the L858R point mutation in exon 21. In Han patients we found 21 (44.7%) cases of exon 19 deletion, 24 (51.1%) cases of L858R in exon 21, 1 case (2.1%) with mutations in both exon 19 and exon 21, and 1 case (2.1%) with T790 mutation in exon 20. In Uighur patients we found 8 (66.7%) cases of exon 19 deletion and 4 (33.3%) cases of L858R in exon 21.
  
  
  CONCLUSIONS
  In comparing these groups, the exon 19 deletion was more common than L858R in exon 21 in Uighur patients. In Han patients, EGFR-sensitive mutations occurred in female, never-smoking patients with well-differentiated tumors; but for Uighur patients only smoking history showed an obvious correlation.
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. Liudeyouxiang66@sina.com.
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. Wangxiulitongtong@163.com.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. 1056923979@qq.com.
authors.forename: Hongge
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. 1615369202@qq.com.
authors.forename: Chunling
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. 1518437725@qq.com.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. 819502412@qq.com.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. dhjhuihui@126.com.
authors.forename: Huijie
authors.initials: H
authors.lastname: Duan
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. zy_622@sina.com.
authors.forename: Jia
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. 2001xiaogu@163.com.
authors.forename: Guomin
authors.initials: G
authors.lastname: Gu
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. Yiyizhansci@163.com.
authors.forename: Yiyi
authors.initials: Y
authors.lastname: Zhan
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. Yiyizhansci@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. 1662192765@qq.com.
authors.forename: Kahaer
authors.initials: K
authors.lastname: Abuduwaili
authors.affiliation: Department of Pulmonary medicine, The Third Affiliated Hospital of Xinjiang Medical University, Wulumuqi, 830011, China. louis3.6@163.com.
authors.forename: Su
authors.initials: S
authors.lastname: Qionglu
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D002681:China / Q000208:ethnology; D005260:Female; D018773:Genes, erbB-1; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation