title: G-Protein β3-Subunit Gene C825T Polymorphism and Cardiovascular Risk: An Updated Review.
abstract: Hypertension is a common disorder of multifactorial origin that constitutes a major risk factor for cardiovascular events such as stroke and myocardial infarction. The subunits of the heterotrimeric G proteins are attractive candidate gene products for susceptibility to hypertension, obesity and insulin resistance syndrome. A polymorphism (825C/T) in exon 10 of the GNB3 gene, encoding for the Gβ3 subunit, has been described. The 825T allele is associated with alternative splicing of the gene and formation of a truncated but functionally active β3 subunit. Many studies have investigated whether carriers of the 825T allele are at increased risk for hypertension, obesity, insulin-resistance and left ventricular hypertrophy with apparently conflicting results. The present review demonstrates that GNB3 825T allele is a useful genetic marker for better defining the risk profile of hypertensive patients, as it is associated with increased risk of stroke and myocardial infarction in longitudinal studies in Caucasians.
authors.affiliation: Department of Medicine, University of Padua, Padua, Italy, andrea.semplicini@unipd.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Semplicini
authors.forename: Tommaso
authors.initials: T
authors.lastname: Grandi
authors.forename: Chiara
authors.initials: C
authors.lastname: Sandonà
authors.forename: Arianna
authors.initials: A
authors.lastname: Cattelan
authors.forename: Giulio
authors.initials: G
authors.lastname: Ceolotto
mesh_terms: D000483:Alleles; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics*; D000075222:Essential Hypertension; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D017379:Hypertrophy, Left Ventricular / Q000235:genetics*; D024821:Metabolic Syndrome / Q000235:genetics; D009765:Obesity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000208:ethnology / Q000235:genetics*
chemical_list: C000595803:GNB3 protein, human; D020962:Heterotrimeric GTP-Binding Proteins