title: Macrophage activation: on par with LPS.
abstract: The inflammatory response is a critical component of the immune system that is activated by stimuli such as cytokines, foreign DNA, RNA, or other harmful substances. Krukenberg et al. (2015) identify poly(ADP-ribose) as a new signaling molecule that activates inflammation, thus providing yet another mechanism by which PARPs are involved in cellular stress responses.
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA.
authors.forename: Florian J
authors.initials: FJ
authors.lastname: Bock
authors.affiliation: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. Electronic address: pchang2@mit.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Chang
mesh_terms: D000818:Animals; D006801:Humans; D011064:Poly Adenosine Diphosphate Ribose / Q000494:pharmacology*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D011064:Poly Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases