title: Papillary thyroid carcinoma and multiple endocrine neoplasia type 2.
abstract: BACKGROUND
  Papillary thyroid carcinoma (PTC) is exceptional in MEN 2.
  
  
  RESULTS
  The analysis in 135 patients revealed two PTC, without C-cell pathology; both being positive for V804M mutation (RET proto-oncogene).
  
  
  CONCLUSIONS
  Few data are available about PTC in MEN 2, and without C-cell pathology is even less common. More studies are needed to correlate genetics and histology, and even for assessing PTC as only manifestation of MEN 2.
authors.affiliation: Service of General Surgery, Unit of Endocrine Surgery, Instituto Murciano de Investigaciones Biomédicas (IMIB), Virgen de la Arrixaca Clinical Universitary Hospital, Crta./Madrid-Cartagena, s/n. El Palmar, 30120, Murcia, Spain. beatrizfebrero@hotmail.com.
authors.forename: B
authors.initials: B
authors.lastname: Febrero
authors.affiliation: Service of General Surgery, Unit of Endocrine Surgery, Instituto Murciano de Investigaciones Biomédicas (IMIB), Virgen de la Arrixaca Clinical Universitary Hospital, Crta./Madrid-Cartagena, s/n. El Palmar, 30120, Murcia, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Rodríguez
authors.affiliation: Service of General Surgery, Unit of Endocrine Surgery, Instituto Murciano de Investigaciones Biomédicas (IMIB), Virgen de la Arrixaca Clinical Universitary Hospital, Crta./Madrid-Cartagena, s/n. El Palmar, 30120, Murcia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Ríos
authors.affiliation: Service of Endocrinology, Virgen de la Arrixaca Clinical Universitary Hospital, Crta./Madrid-Cartagena, s/n. El Palmar, 30120, Murcia, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Portillo
authors.affiliation: Service of General Surgery, Unit of Endocrine Surgery, Instituto Murciano de Investigaciones Biomédicas (IMIB), Virgen de la Arrixaca Clinical Universitary Hospital, Crta./Madrid-Cartagena, s/n. El Palmar, 30120, Murcia, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Parrilla
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000453:epidemiology / Q000235:genetics*; D018276:Carcinoma, Medullary / Q000453:epidemiology / Q000235:genetics*; D002291:Carcinoma, Papillary; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D018813:Multiple Endocrine Neoplasia Type 2a / Q000453:epidemiology / Q000235:genetics*; D009154:Mutation; D000090063:Proto-Oncogene Mas; D051096:Proto-Oncogene Proteins c-ret / Q000235:genetics*; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics*
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D051096:Proto-Oncogene Proteins c-ret; C099282:RET protein, human
keywords: Medullary carcinoma; Multiple endocrine neoplasia type 2; Papillary carcinoma; RET mutation; Thyroid carcinoma