title: A new anthraquinone from seed of Cassia obtusifolia.
abstract: Seeds of Cassia obtusifolia L. are known as homology of medicine and food material, which is a commonly consumed beverage in China. One new compound, 8-hydroxy-1,7-dimethoxy-3-methylanthracene-9,10-dione-2-O-β-d-glucoside (1), together with 11 known compounds, including seven anthraquinones (2-8), was isolated from the seeds. The 2D NMR data of compound 2 are reported for the first time. The structures of the compounds were established on the basis of 1D and 2D NMR, IR and HR-ESI-MS spectra. The cytotoxic activities of all the compounds against five cell lines (LO2, HCT-116, A549, HepG2 and SGC7901) were evaluated by using CCK8 methods. Compounds 1, 3 and 7 show moderate cytotoxicity towards HCT-116 cells compared with oxaliplatin.
authors.affiliation: a Nanjing Institute for Comprehensive Utilization of Wild Plants , Nanjing 210042 , P.R. China.
authors.forename: Bao-jun
authors.initials: BJ
authors.lastname: Shi
authors.affiliation: c Department of Pharmacy , School of Stomatology, Fourth Military Medical University , Xi'an 710032 , P.R. China.
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Zhang
authors.affiliation: a Nanjing Institute for Comprehensive Utilization of Wild Plants , Nanjing 210042 , P.R. China.
authors.forename: Hong-fang
authors.initials: HF
authors.lastname: Jiang
authors.affiliation: a Nanjing Institute for Comprehensive Utilization of Wild Plants , Nanjing 210042 , P.R. China.
authors.forename: Yu-yao
authors.initials: YY
authors.lastname: Zhu
authors.affiliation: a Nanjing Institute for Comprehensive Utilization of Wild Plants , Nanjing 210042 , P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.affiliation: b College of Life Science and Technology, China Pharmaceutical University , Nanjing 210009 , P.R. China.
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Zha
authors.affiliation: b College of Life Science and Technology, China Pharmaceutical University , Nanjing 210009 , P.R. China.
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Lu
authors.affiliation: a Nanjing Institute for Comprehensive Utilization of Wild Plants , Nanjing 210042 , P.R. China.
authors.forename: Wei-ming
authors.initials: WM
authors.lastname: Zhang
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D002366:Cassia / Q000737:chemistry*; D045744:Cell Line, Tumor / Q000187:drug effects; D002681:China; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology; D045325:HCT116 Cells / Q000187:drug effects; D056945:Hep G2 Cells / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000494:pharmacology; D000077150:Oxaliplatin; D012639:Seeds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C000609423:8-hydroxy-1,7-dimethoxy-3-methylanthracene-9,10-dione-2-O-beta-D-glucoside; D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin
keywords: Cassia obtusifolia; anthraquinone; antineoplastic activity