title: Cardiac aging - Getting to the stem of the problem.
abstract: Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. This review summarizes findings in support of the "stem cell hypothesis of aging" and discusses the impact of age on cardiac stem cells and the niche. This article is part of a Special Issue entitled 'CV Aging'.
authors.affiliation: Department of Biology, San Diego State University Heart Institute, San Diego State University, San Diego, CA 92182, USA. Electronic address: nirmala.hariharan@gmail.com.
authors.forename: Nirmala
authors.initials: N
authors.lastname: Hariharan
authors.affiliation: Department of Biology, San Diego State University Heart Institute, San Diego State University, San Diego, CA 92182, USA. Electronic address: heartman4ever@icloud.com.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Sussman
mesh_terms: D000375:Aging / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D009202:Cardiomyopathies / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D051379:Mice; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D013045:Species Specificity; D055153:Stem Cell Niche / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000378:metabolism / Q000473:pathology*
keywords: Aging; Cardiac stem/progenitor cells; Heart