title: Strong nucleosomes of yeasts.
abstract: Yeast genome lacks visibly periodic sequences characteristic of strong nucleosomes (SNs) originally discovered in A. thaliana, C. elegans, and H. sapiens. Yet, the sequences with good match to the (RRRRRYYYYY)n consensus of the SNs do show preference to centromere regions of Schizosaccharomyces pombe, Saccharomyces cerevisiae, and Cryptococcus neoformans - property characteristic of SNs of higher eukaryotes. Candida albicans is the first exception detected so far, where their SNs do not have any affinity to the centromeres, nor pericentromeric regions. Three of the four yeast genomes analyzed possess unique repeating centromere-specific SN sequences (C. albicans, again, is an exception). The results firmly indicate that centromeres of plants, animals, and yeasts in general have special chromatin structure, favoring SNs.
authors.affiliation: a Genome Diversity Center, Institute of Evolution , University of Haifa , Mount Carmel, Haifa 3498838 , Israel.
authors.forename: Edward N
authors.initials: EN
authors.lastname: Trifonov
authors.affiliation: a Genome Diversity Center, Institute of Evolution , University of Haifa , Mount Carmel, Haifa 3498838 , Israel.
authors.forename: Vijay
authors.initials: V
authors.lastname: Tripathi
mesh_terms: D001483:Base Sequence; D002503:Centromere / Q000378:metabolism; D015825:Chromosomes, Fungal / Q000235:genetics; D017124:Conserved Sequence; D004271:DNA, Fungal / Q000235:genetics; D008969:Molecular Sequence Data; D009707:Nucleosomes / Q000378:metabolism*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D015003:Yeasts / Q000235:genetics*
chemical_list: D004271:DNA, Fungal; D009707:Nucleosomes
keywords: 601-like nucleosomes; C. albicans; C. neoformans; S. cerevisiae; S. pombe; centromere; strong nucleosomes; yeast genomes