title: Functions of thymic stromal lymphopoietin in non-allergic diseases.
abstract: Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine produced mainly by epithelial cells. Many studies indicate that TSLP contributes to promote T helper (Th) 2 immune responses which are associated with the pathogenesis of allergic inflammatory diseases. Base on the cross-talk between Th2 inflammation and cancers, we will highlight the role of TSLP in the progression of cancers in this review. TSLP is involved in the increasing prevalence of Tregs in the cancer microenvironment. Besides, TSLP has an important role in promoting the growth of vascular endothelial cells and angiogenesis, which could further promote the development and progression of cervical cancer. It gives the evidence that TSLP could induce EMT to promote cancer metastasis. In addition, TSLP could be detected in some fibroblasts and may play a role in the pathogenesis of non-allergic diseases characterized by a type 2 immune response and organ fibrosis.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China; College of Pharmaceutical Science, Zhejiang University, Hangzhou 310028, China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Ying
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Yanlu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Tang
authors.affiliation: College of Pharmaceutical Science, Zhejiang University, Hangzhou 310028, China. Electronic address: tgq1990414@163.com.
authors.forename: Shuqing
authors.initials: S
authors.lastname: Chen
mesh_terms: D000818:Animals; D016207:Cytokines / Q000276:immunology*; D058750:Epithelial-Mesenchymal Transition / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D016207:Cytokines; D000094632:Thymic Stromal Lymphopoietin
keywords: Cancer; Fibrosys; Metastasis; TSLP; Tregs