title: Present and future contraception: does discovery of targets lead to new contraceptives?
abstract: Although many highly effective methods of reversible contraception are available, high rates of unintended pregnancy and abortion provide evidence that current methods do not meet the needs of all couples. In recent years, a number of highly specific targets have been identified in key pathways that regulate the development of male and female gametes. Support for development of novel approaches has moved from industry to governmental and foundation funders. Continued public funding will be needed to move promising leads into clinical trials.
authors.affiliation: a 1 Oregon National Primate Research Center, Division of Reproductive and Developmental Science , Beaverton, OR 97006, USA.|b 2 Oregon Health and Science University, Women's Health Research Unit, Department of Obstetrics and Gynecology , mail code UHN-70, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA +1 503 418 4500, +1 503 494 5113, +1 503 533 2445 ; +1 503 494 3130 ; jensenje@ohsu.edu.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Jensen
mesh_terms: D000818:Animals; D003267:Contraception / Q000379:methods*; D003270:Contraceptive Agents / Q000008:administration & dosage*; D015195:Drug Design; D005260:Female; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D011247:Pregnancy; D011275:Pregnancy, Unwanted
chemical_list: D003270:Contraceptive Agents
keywords: contraception; female; male; targets