title: New strategies for rapid (18)F-radiolabeling of biomolecules for radionuclide-based in vivo imaging.
abstract: The increasing availability of highly active no-carrier-added [(18)F]-fluoride makes its use in radiolabeling biomolecules attractive. By incorporating "fluorophilic" elements (Si, B, and Al) into biomolecules, recent advances offer mild and rapid (18)F-labeling approaches without HPLC purification at the radiosynthetic stage while maintaining sufficient specific activity. In this Topical Review, we will discuss the most recent strides in the field.
authors.affiliation: †Department of Chemistry, Key Laboratory of Systems Bioengineering (the Ministry of Education), Tianjin University, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, P. R. China.
authors.forename: Jun-Liang
authors.initials: JL
authors.lastname: Zeng
authors.affiliation: ‡Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, P. R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: †Department of Chemistry, Key Laboratory of Systems Bioengineering (the Ministry of Education), Tianjin University, and Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300072, P. R. China.
authors.forename: Jun-An
authors.initials: JA
authors.lastname: Ma
mesh_terms: D000535:Aluminum / Q000737:chemistry; D000818:Animals; D001895:Boron / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005459:Fluorides / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D006801:Humans; D007553:Isotope Labeling / Q000191:economics / Q000379:methods*; D049268:Positron-Emission Tomography / Q000191:economics / Q000379:methods*; D012825:Silicon / Q000737:chemistry; D013997:Time Factors
chemical_list: D005462:Fluorine Radioisotopes; D000535:Aluminum; D001895:Boron; D005459:Fluorides; D012825:Silicon