title: Herbal medicine treatment for drug-induced parkinsonism.
abstract: OBJECTIVE
  To evaluate the role of herbal medicine in drug-induced parkinsonism (DIP) and identify an optimal treatment approach.
  
  
  METHODS
  Retrospective review of DIP cases treated with herbal medicine.
  
  
  METHODS
  The Parkinson's clinic at Kyung Hee Traditional Korean Medicine Hospital, Korea.
  
  
  METHODS
  Twenty-one patients whose clinical outcome and offending drug could be identified.
  
  
  METHODS
  Clinical features, treatments, and outcomes and summarized the clinical course and treatment in each case.
  
  
  RESULTS
  Twelve patients had levosulpiride-induced parkinsonism and 9 had parkinsonism induced by another drug. The offending drugs were discontinued in all patients, and all patients received herbal medications during treatment. Nine of 12 patients with parkinsonism from levosulpiride and 4 of 9 patients with parkinsonism from other drugs had complete reversal of symptoms. The most frequently used herbal formula was Ukgansan (Yigansan). DIP in the levosulpiride group tended to improve faster with herbal medicine, and the percentage of improvement was higher.
  
  
  CONCLUSIONS
  Optimal herbal medicine treatments chosen after a careful history and evaluation for risk factors may be helpful in reversing DIP.
authors.affiliation: 1 Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University , Seoul, Korea.
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Shim
authors.forename: Joo-Young
authors.initials: JY
authors.lastname: Park
authors.forename: Won-Woo
authors.initials: WW
authors.lastname: Choi
authors.forename: In-Kyu
authors.initials: IK
authors.lastname: Min
authors.forename: Seong-Uk
authors.initials: SU
authors.lastname: Park
authors.forename: Woo-Sang
authors.initials: WS
authors.lastname: Jung
authors.forename: Sang-Kwan
authors.initials: SK
authors.lastname: Moon
authors.forename: Jung-Mi
authors.initials: JM
authors.lastname: Park
authors.forename: Chang-Nam
authors.initials: CN
authors.lastname: Ko
authors.forename: Ki-Ho
authors.initials: KH
authors.lastname: Cho
authors.forename: Seung-Yeon
authors.initials: SY
authors.lastname: Cho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000188:drug therapy*; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000008:administration & dosage*; D056910:Republic of Korea; D012189:Retrospective Studies
chemical_list: D010936:Plant Extracts