title: Immune Mechanisms Are Major Players in Cancer.
abstract: Vaccination with sipuleucel-T produced IgG antibodies to secondary prostatic carcinoma antigens and prolonged survival in some patients, and assaying for antibodies may provide prognostic information and identify new vaccine targets. Additional approaches to improve T-cell responses are needed to improve the clinical efficacy. See related article by GuhaThakurta et al., p. 3619.
authors.affiliation: Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington. hellsk@u.washington.edu.
authors.forename: Karl Erik
authors.initials: KE
authors.lastname: Hellstrom
authors.affiliation: Department of Pathology, Harborview Medical Center, University of Washington, Seattle, Washington.
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Hellstrom
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood*; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D064129:Prostatic Neoplasms, Castration-Resistant / Q000097:blood*
chemical_list: D000951:Antigens, Neoplasm; D007074:Immunoglobulin G