title: Behavioral effects of neonatal lesions on the cerebellar system.
abstract: Several rodent models with spontaneous mutations causing cerebellar pathology are impaired in motor functions during the neonatal period, including Grid2(Lc), Rora(sg), Dab1(scm), Girk2(Wv), Lmx1a(dr-sst), Myo5a(dn), Inpp4a(wbl), and Cacna1a(rol) mice as well as shaker and dystonic rats. Deficits are also evident in murine null mutants such as Zic1, Fgfr1/FgFr2, and Xpa/Ercc8. Behavioral deficits are time-dependent following X-irradiated- or aspiration-induced lesions of the cerebellum in rats. In addition, motor functions are deficient after lesions in cerebellar-related pathways. As in animal subjects, sensorimotor disturbances have been described in children with cerebellar lesions. These results underline the importance of the cerebellum and its connections in the development of motor functions.
authors.affiliation: Université de Rouen, Département Psychologie, Laboratoire ICONES EA 4699, 76821 Mont-Saint-Aignan Cedex, France. Electronic address: robert.lalonde@univ-rouen.fr.
authors.forename: Robert
authors.initials: R
authors.lastname: Lalonde
authors.affiliation: Université de Lorraine, Laboratoire "Stress, Immunité, Pathogènes" EA 7300, and Service de Microscopie Electronique, Faculté de Médecine, 9 avenue de la Forêt de Haye, and CHU de Nancy, 54500 Vandoeuvre-les-Nancy, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Strazielle
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001240:Aspirations, Psychological; D002526:Cerebellar Diseases / Q000150:complications / Q000209:etiology / Q000235:genetics; D002531:Cerebellum / Q000473:pathology; D002658:Developmental Disabilities / Q000209:etiology*; D001523:Mental Disorders / Q000209:etiology*; D051379:Mice; D008817:Mice, Mutant Strains; D009043:Motor Activity / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D009474:Neurons / Q000473:pathology; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000235:genetics; D011832:Radiation Injuries / Q000150:complications; D051381:Rats; D011922:Rats, Mutant Strains; D013997:Time Factors
chemical_list: D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; C539739:Rora protein, mouse
keywords: Body righting; Cerebellar mutants; Cerebellum; Granule cells; Motor coordination; Paw-clasping; Purkinje cells; Rotorod; SHIRPA; Stationary beam; Wire suspension; X-Irradiation