title: SNP-SNP interactions of immunity related genes involved in the CD28/B7 pathway with susceptibility to invasive ductal carcinoma of the breast.
abstract: To explore the interactions among immunity related genes and the risk of breast cancer (BC), 376 invasive ductal carcinoma (IDC) of the breast cases and 366 healthy controls were selected into our study. Twenty single nucleotide polymorphisms (SNPs) of five immunological genes in the CD28/B7 pathway were genotyped. Overall, five SNPs filtered by the Relief F algorithm were rs733618, rs11889031, rs4553808, rs4675374 and rs10754339. The best model of multifactor dimensionality reduction (MDR) contained rs733618 and rs11889031. The high risk genotype combination contributed to increasing risk of breast cancer (odds ratio (OR), 4.36; 95% confidence interval (CI); 3.15-6.02). The information gain (IG) value of these two SNPs was 8.07%, presented the strongest interaction effect. Five significant multiplicative interactions and seven significant combining effects were found among the filtered SNPs. Moreover, the filtered SNPs were still stable in the groups of ER(+), PR(+), CerbB2(-) and lymph node (LN) involvement positive with the best models including rs733618 and rs11889031. The most frequent haplotype was TACC which significantly increased breast cancer risk (OR, 1.80; 95% CI, 1.43-2.25). These results suggested that interactions among cytotoxic T lymphocyte antigen-4 (CTLA4), inducible co-stimulator (ICOS) and B7H4 might play critical roles on the risk of breast cancer.
authors.affiliation: Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhifu
authors.affiliation: Health Management College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, PR China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Mingli
authors.affiliation: Department of Immunology, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Shuang
authors.affiliation: Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, PR China.
authors.forename: Wang
authors.initials: W
authors.lastname: Fan
authors.affiliation: Department of Immunology, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, PR China.
authors.forename: Fu
authors.initials: F
authors.lastname: Zhenkun
authors.affiliation: Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, PR China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wangyang
authors.affiliation: Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, PR China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Guangxiao
authors.affiliation: Department of Epidemiology, Public Health College, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, PR China. Electronic address: zhao_yashuang@263.net.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yashuang
authors.affiliation: Department of Immunology, Harbin Medical University, 157, Baojian Street, Nangang District, Harbin, Heilongjiang Province, PR China. Electronic address: dianjunli@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Dianjun
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000235:genetics / Q000276:immunology*; D018106:CD28 Antigens / Q000276:immunology*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000276:immunology*; D018592:Cross-Over Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007109:Immunity / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D018106:CD28 Antigens
keywords: Breast cancer; CD28/B7 pathway; Interaction; MDR; SNP