title: A modularly designed fluorescence molecular tomography system for multi-modality imaging.
abstract: Nowadays multi-modality imaging has gained great interest in biology research by offering complementary information. In this paper, a modularly designed fluorescence molecular tomography (FMT) system has been developed, which can be not only used as a standalone imaging device, but also feasibly integrated with other imaging modalities, such as X-ray computed tomography (X-CT), single photon emission computed tomography (SPECT) and positron emission tomography (PET), to perform multi-modality imaging in a sequential manner. The system rotates the CCD camera and the excitation light source in the vertical plane, while the animal is stationed on a horizontally moveable transparent animal holder at its natural prone position. FMT and other imaging modalities are co-registered automatically. Phantom and animal experiments have been carried out to demonstrate the performance of the system. The accurate results show that this innovative flexible FMT system has a great potential to be a powerful tool for the study of small animal disease models.
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, China.
authors.forename: Guohe
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, China.
authors.forename: Yichen
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Jingsong
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, China.
authors.forename: Yanye
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, China.
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Shi
authors.affiliation: Department of Biomedical Engineering, Tsinghua University, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, China.
authors.forename: Qiushi
authors.initials: Q
authors.lastname: Ren
authors.affiliation: Department of Biomedical Engineering, Peking University, Beijing, China.
authors.forename: Changhui
authors.initials: C
authors.lastname: Li
mesh_terms: D000465:Algorithms; D000818:Animals; D005456:Fluorescent Dyes / Q000737:chemistry; D007091:Image Processing, Computer-Assisted; D007208:Indocyanine Green / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D064847:Multimodal Imaging / Q000379:methods*; D061848:Optical Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D005456:Fluorescent Dyes; D007208:Indocyanine Green
keywords: Fluorescence molecular tomography; fluorescence imaging; multi-modality imaging