title: Clinical application of ultrasound-guided core needle biopsy with multiple punches in the diagnosis of lymphoma.
abstract: BACKGROUND
  The purpose of this study is to investigate the feasibility, accuracy, and limitations of ultrasound (US)-guided core needle biopsy (CNB) with multiple punches in the diagnosis of lymphoma in the whole body.
  
  
  METHODS
  From March 2007 to October 2013, US-guided CNB with multiple punches was performed by well-experienced radiologists in 110 patients (CNB group), and surgical biopsy was carried out in 95 patients (surgical group). The differences of accuracy rate between the two groups in the diagnosis of lymphoma and its subtypes were examined with Fisher's exact test.
  
  
  RESULTS
  There were no statistical differences between the CNB group and the surgical group in the diagnostic accuracy rate of lymphoma, as well as its subtypes in superficial and deep masses. In addition, in the CNB group, there were no statistical differences between different lengths of lesions in the diagnosis accuracy rate of lymphoma and its subtypes.
  
  
  CONCLUSIONS
  US-guided CNB with no less than three punches is an accurate, safe, minimally invasive, non-radiological, fast, and cost-effective method in the evaluation of lymphoma and its subtypes as compared with surgical approach. It should be considered as the acceptable alternative to surgical biopsy to obtain histopathological samples in the patients with suspected lymphoma.
authors.affiliation: Department of Ultrasound, The Cancer Hospital of Nantong University, No. 30 Tongyang North Road, Pingchao Town, Tongzhou District, Nantong, 226361, China. heying0520@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Ultrasound, The Cancer Hospital of Nantong University, No. 30 Tongyang North Road, Pingchao Town, Tongzhou District, Nantong, 226361, China. jixiuzhen123@163.com.
authors.forename: Xiuzhen
authors.initials: X
authors.lastname: Ji
authors.affiliation: Department of Ultrasound, The First Affiliated Hospital of Nantong University, No. 20 Xisi Road, Nantong, 226001, China. xieyanggui@yeah.net.
authors.forename: Yanggui
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Radiology, The Second Affiliated Hospital of Nantong University, No.6 Hai Er Xiang North Road, Nantong, Jiangsu, 226001, P.R. China. hebosheng@126.com.
authors.forename: Bosheng
authors.initials: B
authors.lastname: He
authors.affiliation: Department of Oncology, The Cancer Hospital of Nantong University, No. 30 Tongyang North Road, Pingchao Town, Tongzhou District, Nantong, 226361, China. xuxiaohong001@yeah.net.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Pathology, The Cancer Hospital of Nantong University, No. 30 Tongyang North Road, Pingchao Town, Tongzhou District, Nantong, 226361, China. xuxudong001@126.com.
authors.forename: Xudong
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Ultrasound, The Cancer Hospital of Nantong University, No. 30 Tongyang North Road, Pingchao Town, Tongzhou District, Nantong, 226361, China. zhangqin0520@yeah.net.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D062005:Biopsy, Large-Core Needle / Q000295:instrumentation / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D061705:Image-Guided Biopsy; D008223:Lymphoma / Q000145:classification / Q000175:diagnosis* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D014463:Ultrasonography / Q000379:methods*