title: Extracorporeal photopheresis for the treatment of autoimmune diseases.
abstract: The immune system is tasked with the unique challenge of recognizing foreign pathogens and damaged cells while at the same time preserving and protecting the integrity of "self". When this process fails, severe consequences including cancer and autoimmunity are the end result. Current therapies aimed at treating autoimmune disorders result in generalized immunosuppression and place the patient at increased risk for infection and malignancy. ECP is a potential therapeutic intervention that recapitulates natural physiologic processes of tolerance induction to restore immune homeostasis. Several clinical trials suggest that ECP may be used to treat a broad spectrum of autoimmune diseases.
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ, USA. Electronic address: Adamski.Jill@mayo.edu.
authors.forename: Jill
authors.initials: J
authors.lastname: Adamski
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ, USA.
authors.forename: Theresa
authors.initials: T
authors.lastname: Kinard
authors.affiliation: Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
authors.forename: Tina
authors.initials: T
authors.lastname: Ipe
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Cooling
mesh_terms: D000818:Animals; D017209:Apoptosis; D001172:Arthritis, Rheumatoid / Q000628:therapy; D001327:Autoimmune Diseases / Q000628:therapy*; D002986:Clinical Trials as Topic; D003424:Crohn Disease / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy; D004802:Eosinophilia / Q000628:therapy; D016107:Epidermolysis Bullosa Acquisita / Q000628:therapy; D005208:Fasciitis / Q000628:therapy; D006706:Homeostasis; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008010:Lichen Planus / Q000628:therapy; D008180:Lupus Erythematosus, Systemic / Q000628:therapy; D009103:Multiple Sclerosis / Q000628:therapy; D010392:Pemphigus / Q000628:therapy; D017893:Photopheresis / Q000379:methods*; D011565:Psoriasis / Q000628:therapy; D012595:Scleroderma, Systemic / Q000628:therapy; D053718:Scleromyxedema / Q000628:therapy; D013167:Spondylitis, Ankylosing / Q000628:therapy; D050378:T-Lymphocytes, Regulatory / Q000166:cytology
chemical_list: D007166:Immunosuppressive Agents
keywords: Autoimmune; ECP; Photopheresis