title: VSTM-v1, a potential myeloid differentiation antigen that is downregulated in bone marrow cells from myeloid leukemia patients.
abstract: Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. Herein, we report a potential leukocyte differentiation antigen gene VSTM1 (V-set and transmembrane domain-containing 1) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation. The expression level of its predominant encoded product, VSTM1-v1, was positively correlated with myeloid cell maturation state. Restoration of VSTM1-v1 expression inhibited myeloid leukemia cells' growth. Therefore, VSTM1-v1 might represent an important myeloid leukocyte differentiation antigen and provide a potential target for the diagnosis and treatment of leukemia.
authors.affiliation: Peking University People's Hospital and Institute of Hematology, 11 Xi-Zhi-Men South Street, Beijing, 100044, China. xiemin@bjmu.edu.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Xie
authors.affiliation: Peking University Center for Human Disease Genomics, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. tingfanta@163.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: Peking University People's Hospital and Institute of Hematology, 11 Xi-Zhi-Men South Street, Beijing, 100044, China. 15010367083@163.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Peking University People's Hospital and Institute of Hematology, 11 Xi-Zhi-Men South Street, Beijing, 100044, China. jinlanli698@aliyun.com.
authors.forename: Jinlan
authors.initials: J
authors.lastname: Li
authors.affiliation: Peking University People's Hospital and Institute of Hematology, 11 Xi-Zhi-Men South Street, Beijing, 100044, China. yaoqiumei1991@163.com.
authors.forename: Qiumei
authors.initials: Q
authors.lastname: Yao
authors.affiliation: Peking University Center for Human Disease Genomics, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. hanwl@bjmu.edu.cn.
authors.forename: Wenling
authors.initials: W
authors.lastname: Han
authors.affiliation: Peking University People's Hospital and Institute of Hematology, 11 Xi-Zhi-Men South Street, Beijing, 100044, China. ruanguorui@pkuph.edu.cn.
authors.forename: Guorui
authors.initials: G
authors.lastname: Ruan
mesh_terms: D000943:Antigens, Differentiation / Q000096:biosynthesis; D015153:Blotting, Western; D001854:Bone Marrow Cells / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D015536:Down-Regulation; D006801:Humans; D007951:Leukemia, Myeloid / Q000378:metabolism* / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011971:Receptors, Immunologic / Q000096:biosynthesis*
chemical_list: D000943:Antigens, Differentiation; D011971:Receptors, Immunologic; C550469:VSTM1 protein, human