title: From worms to targeting virulence factors.
abstract: Rising antibiotic resistance means that alternative antibacterial strategies are sorely needed. In this issue, Zhu et al. (2015) report the use of a Caenorhabditis elegans model to validate the Pseudomonas aeruginosa virulence factor LasB as a potential therapeutic target and to identify a LasB inhibitor with in vivo efficacy.
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
authors.forename: Roberta J
authors.initials: RJ
authors.lastname: Melander
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: ccmeland@ncsu.edu.
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D017173:Caenorhabditis elegans / Q000382:microbiology*; D008666:Metalloendopeptidases / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors; D008666:Metalloendopeptidases