title: Unnatural agrochemical ligands for engineered abscisic acid receptors.
abstract: Existing agrochemicals can be endowed with new applications through protein engineering of plant receptors. A recent study shows an engineered PYR1 ABA receptor can be activated by mandipropamid. Plants engineered with such PYR1 variant are responsive to this agrochemical, which confers protection against drought through activation of ABA signaling.
authors.affiliation: Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universidad Politécnica de Valencia, 46022 Valencia, Spain. Electronic address: prodriguez@ibmcp.upv.es.
authors.forename: Pedro L
authors.initials: PL
authors.lastname: Rodriguez
authors.affiliation: Department of Botany and Plant Sciences, Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521, USA.
authors.forename: Jorge
authors.initials: J
authors.lastname: Lozano-Juste
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism*; D016573:Agrochemicals / Q000494:pharmacology*; D000577:Amides / Q000494:pharmacology*; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism*; D002264:Carboxylic Acids / Q000494:pharmacology*; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism*; D010944:Plants / Q000187:drug effects* / Q000378:metabolism*; D014867:Water / Q000378:metabolism*
chemical_list: D016573:Agrochemicals; D000577:Amides; D029681:Arabidopsis Proteins; D002264:Carboxylic Acids; D026901:Membrane Transport Proteins; D014867:Water; D000040:Abscisic Acid
keywords: agrochemical; engineered ABA receptor; orthogonal ligand-receptor; unnatural ligand