title: Loss of e-cadherin and retinoblastoma genes in a case of urothelial carcinoma with scrotal metastasis.
abstract: Cutaneous metastases from urologic cancers are very uncommon, usually represent widespread metastatic disease and are associated with a very poor prognosis. They may occur in 1% of patients with urologic malignancies, most commonly from kidney, followed by bladder and prostate tumors. In this report, we describe a case of urothelial carcinoma with metastases to the scrotum treated with platinum based chemotherapy with a durable complete response lasting more than 14 months. Molecular profiling revealed deleterious mutations in e-cadherin and retinoblastoma genes, suggesting their possible role in the pathogenesis of cutaneous metastases. Further studies are needed to validate this observation.
authors.affiliation: Temple University Hospital, Philadelphia, Pennsylvania, USA.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Norberg
authors.forename: Michelle
authors.initials: M
authors.lastname: Oros
authors.forename: Varsha
authors.initials: V
authors.lastname: Manucha
authors.forename: Daniel
authors.initials: D
authors.lastname: Eun
authors.forename: Marijo
authors.initials: M
authors.lastname: Bilusic
mesh_terms: D000369:Aged, 80 and over; D015820:Cadherins / Q000235:genetics*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000235:genetics* / Q000556:secondary; D004358:Drug Therapy; D016161:Genes, Retinoblastoma / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D012611:Scrotum; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000556:secondary; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology
chemical_list: D015820:Cadherins