title: Myoepithelial carcinoma of the stomach: a diagnostic pitfall.
abstract: Myoepithelioma/myoepithelial carcinomas are not commonly found in soft tissues and are especially rare at visceral sites. This report describes a case of a rare low-grade myoepithelial carcinoma of the stomach. A 61-year-old female patient presented with postprandial abdominal discomfort. Endoscopy revealed a 1.1 cm submucosal lesion. Local excision was performed after malignancy was confirmed by biopsy. The resection margin is free of tumor and she received no adjuvant therapy. The tumor was characterized by multinodular growth with biphasic epithelioid and spindle components. Infiltrative margin and nuclear pleomorphism are seen. Tumor cells were positive for both epithelial and myoepithelial markers. Evidence of epithelial differentiation was confirmed by electron microscopy. No EWSR1 rearrangement was detected. The final diagnosis was low-grade myoepithelial gastric carcinoma. The patient is currently well, and no evidence of recurrence or metastasis was found after ten-month of follow-up. Myoepithelial carcinoma should be considered in the differential diagnosis of a biphasic gastric tumor.
authors.affiliation: Chih-En Tseng, Chen-Lin Chi, Department of Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi 62247, Taiwan.
authors.forename: Chih-En
authors.initials: CE
authors.lastname: Tseng
authors.affiliation: Chih-En Tseng, Chen-Lin Chi, Department of Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi 62247, Taiwan.
authors.forename: Yu-Hsi
authors.initials: YH
authors.lastname: Hsieh
authors.affiliation: Chih-En Tseng, Chen-Lin Chi, Department of Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi 62247, Taiwan.
authors.forename: Chang-Kuo
authors.initials: CK
authors.lastname: Wei
authors.affiliation: Chih-En Tseng, Chen-Lin Chi, Department of Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi 62247, Taiwan.
authors.forename: Hsuan-Ying
authors.initials: HY
authors.lastname: Huang
authors.affiliation: Chih-En Tseng, Chen-Lin Chi, Department of Pathology, Buddhist Dalin Tzu Chi Hospital, Chiayi 62247, Taiwan.
authors.forename: Chen-Lin
authors.initials: CL
authors.lastname: Chi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009208:Myoepithelioma / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
keywords: Myoepithelial carcinoma; Myoepithelioma; Stomach