title: Adhesion molecules in breast carcinoma: a challenge to the pathologist.
abstract: The role of adhesion molecules is very important both in the activation of carcinogenesis and in the differentiation of subtypes of breast carcinoma, aiding in diagnosis, prognosis and therapeutic choice in these tumors. Therefore, understanding the functions and interrelationships among these molecules is crucial to the pathologist, who often uses these factors as a resource to differentiate tumors and further classify them according to a molecular point of view. Our goal is to describe the applicability and the difficulties encountered by the pathologist in the diagnosis of breast carcinoma, discussing the most commonly used markers of adhesion in routine analyses.
authors.affiliation: Faculty of Medicine of ABC, Santo André, SP, Brazil.
authors.forename: Claudia
authors.initials: C
authors.lastname: Rossetti
authors.affiliation: FMABC, Santo André, SP, Brazil.
authors.forename: Beatriz da Costa Aguiar Alves
authors.initials: Bda C
authors.lastname: Reis
authors.affiliation: FMABC, Santo André, SP, Brazil.
authors.forename: Pamela de Oliveira
authors.initials: Pde O
authors.lastname: Delgado
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Ligia Ajaime
authors.initials: LA
authors.lastname: Azzalis
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Virginia B C
authors.initials: VB
authors.lastname: Junqueira
authors.affiliation: FMABC, Santo André, SP, Brazil.
authors.forename: David
authors.initials: D
authors.lastname: Feder
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Fonseca
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D015820:Cadherins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D057167:Claudins / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D045726:Metalloproteases / Q000378:metabolism; D009077:Mucins / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D015815:Cell Adhesion Molecules; D057167:Claudins; D009077:Mucins; D045726:Metalloproteases