title: Femtosecond laser-assisted cataract surgery in Alport syndrome with anterior lenticonus.
abstract: OBJECTIVE
  To report the surgical treatment of 3 eyes of 2 patients with bilateral anterior lenticonus due to Alport syndrome using femtosecond laser-assisted cataract surgery (FLACS).
  
  
  METHODS
  Two patients with Alport syndrome presented to our department due to anterior lenticonus in both eyes. We performed FLACS with posterior chamber lens implantation in both eyes of one patient and in one eye of the other patient. Anterior segment morphologic changes were visualized with a Scheimpflug camera, and anterior segment optical coherence tomography preoperatively and 3 months after surgery. Ultrastructure of the cut capsule edges was observed with scanning electron microscopy and compared to the edge of femtosecond laser capsulotomy performed on an otherwise healthy patient with cataract (control).
  
  
  RESULTS
  The intraocular lens (IOL) postoperative positioning parameters met the international requirements of aspherical and wavefront customized IOLs (tilt &lt;10 degree, decentration &lt;800 µm). Scanning electron microscopy revealed the same characteristics of the cut capsule edges in the Alport and in the control eyes.
  
  
  CONCLUSIONS
  Femtosecond laser cataract surgery can be a safe and successful method for optical rehabilitation of anterior lenticonus in patients with Alport syndrome.
authors.affiliation: Department of Ophthalmology, Semmelweis University, Budapest - Hungary.
authors.forename: Mónika
authors.initials: M
authors.lastname: Ecsedy
authors.affiliation: Department of Ophthalmology, Semmelweis University, Budapest - Hungary.
authors.forename: Gúbor L
authors.initials: GL
authors.lastname: Súndor
authors.affiliation: Department of Ophthalmology, Semmelweis University, Budapest - Hungary.
authors.forename: Úgnes I
authors.initials: ÚI
authors.lastname: Takúcs
authors.affiliation: Department of Ophthalmology, Semmelweis University, Budapest - Hungary.
authors.forename: Kinga
authors.initials: K
authors.lastname: Krúnitz
authors.affiliation: Department of Polymer Engineering, Faculty of Mechanical Engineering, University of Technology and Economics, Budapest - Hungary.
authors.forename: Zoltún
authors.initials: Z
authors.lastname: Kiss
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Semmelweis University, Budapest - Hungary.
authors.forename: Krasimir
authors.initials: K
authors.lastname: Kolev
authors.affiliation: Department of Ophthalmology, Semmelweis University, Budapest - Hungary.
authors.forename: Zoltún Z
authors.initials: ZZ
authors.lastname: Nagy
mesh_terms: D000328:Adult; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D007903:Lens Capsule, Crystalline / Q000648:ultrastructure; D007905:Lens Diseases / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D019654:Lens Implantation, Intraocular; D008297:Male; D008855:Microscopy, Electron, Scanning; D009394:Nephritis, Hereditary / Q000150:complications* / Q000503:physiopathology; D018918:Phacoemulsification / Q000379:methods*; D019591:Pseudophakia / Q000209:etiology; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000209:etiology / Q000503:physiopathology / Q000534:rehabilitation; D014792:Visual Acuity / Q000502:physiology