title: Cardiovascular and All-Cause Mortality Over a 23-Year Period Among Chinese With Newly Diagnosed Diabetes in the Da Qing IGT and Diabetes Study.
abstract: OBJECTIVE
  Despite its growing prevalence in China, the extent to which diabetes leads to excess cardiovascular disease (CVD) mortality and all-cause mortality is unclear.
  
  
  METHODS
  We compared death rates and causes of death among 630 people with newly diagnosed diabetes (NDD) and 519 with normal glucose tolerance (NGT) who, in 1986, were identified as a result of screening 110,660 adults aged 25-74 years for diabetes in Da Qing, China.
  
  
  RESULTS
  During 23 years of follow-up, 338 (56.5%) participants with NDD and 100 (20.3%) with NGT died. CVD was the predominant cause of death in those with diabetes (47.5% in men and 49.7% in women), almost half of which was due to stroke (52.3% in men and 42.3% in women). The age-standardized incidence of all-cause death was three times as high in those with NDD as in those with NGT with incidences (per 1,000 person-years) of 36.9 (95% CI 31.5-42.3) vs. 13.3 (10.2-16.5) in men (P < 0.0001) and 27.1 (22.9-31.4) vs. 9.2 (7.8-10.6) in women (P < 0.0001). The incidence of CVD deaths in men and women with NDD (17.5 [13.8-21.2] vs. 13.5 [10.5-16.5]) did not differ significantly. Significantly higher death rates attributable to renal disease and infection were also found in the NDD group.
  
  
  CONCLUSIONS
  Diabetes is associated with a substantially increased risk of death in Chinese adults, especially from CVD, almost half of which is due to stroke.
authors.affiliation: Department of Endocrinology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yali
authors.initials: Y
authors.lastname: An
authors.affiliation: Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA guangwei_li@medmail.com.cn pzhang@cdc.gov.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, Da Qing First Hospital, Da Qing, China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA.
authors.forename: Edward W
authors.initials: EW
authors.lastname: Gregg
authors.affiliation: Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Wenying
authors.initials: W
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Da Qing First Hospital, Da Qing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shuai
authors.affiliation: Department of Endocrinology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, Bethesda, MD.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Engelgau
authors.affiliation: Division of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA.
authors.forename: Yiling
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Cardiology, Da Qing First Hospital, Da Qing, China.
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Bennett
authors.affiliation: Department of Endocrinology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Beijing, China Department of Endocrinology, China-Japan Friendship Hospital, Beijing, China guangwei_li@medmail.com.cn pzhang@cdc.gov.
authors.forename: Guangwei
authors.initials: G
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D002318:Cardiovascular Diseases / Q000208:ethnology / Q000401:mortality*; D002423:Cause of Death; D002681:China / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000208:ethnology / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000208:ethnology / Q000401:mortality; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence