title: A mathematical model of radiation-induced responses in a cellular population including cell-to-cell communications.
abstract: Cell-to-cell communication is an important factor for understanding the mechanisms of radiation-induced responses such as bystander effects. In this study, a new mathematical model of intercellular signalling between individual cells in a cellular population is proposed. The authors considered two types of transmission of signals: via culture medium and via gap junction. They focus on the effects that radiation and intercellular signalling have on cell-cycle modification. The cell cycle is represented as a virtual clock that includes several checkpoint pathways within a cyclic process. They also develop a grid model and set up diffusion equations to model the propagation of signals to and from spatially located cells. The authors have also considered the role that DNA damage plays in the cycle of cells which can progress through the cell cycle or stop at the G1, S, G2 or M-phase checkpoints. Results of testing show that the proposed model can simulate intercellular signalling and cell-cycle progression in individual cells during and after irradiation.
authors.affiliation: Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, Ibaraki, Japan hattori.yuya@jaea.go.jp.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Hattori
authors.affiliation: Microbeam Radiation Biology Group, Japan Atomic Energy Agency, Gunma, Japan.
authors.forename: Michiyo
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Microbeam Radiation Biology Group, Japan Atomic Energy Agency, Gunma, Japan.
authors.forename: Tomoo
authors.initials: T
authors.lastname: Funayama
authors.affiliation: Microbeam Radiation Biology Group, Japan Atomic Energy Agency, Gunma, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, Ibaraki, Japan Research Group for Radiation and Biomolecular Science, Japan Atomic Energy Agency, Ibaraki, Japan.
authors.forename: Akinari
authors.initials: A
authors.lastname: Yokoya
authors.affiliation: Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, Ibaraki, Japan.
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Watanabe
mesh_terms: D017209:Apoptosis / Q000528:radiation effects; D024201:Bystander Effect / Q000528:radiation effects*; D002450:Cell Communication / Q000528:radiation effects*; D002453:Cell Cycle / Q000528:radiation effects*; D002468:Cell Physiological Phenomena / Q000528:radiation effects*; D004249:DNA Damage / Q000528:radiation effects*; D006801:Humans; D008962:Models, Theoretical; D000069079:Radiation Exposure / Q000009:adverse effects*