title: Telaprevir-induced renal impairment: three clinical cases and a review of the literature.
abstract: Telaprevir (TPV) is one of the NS3/4A serine protease inhibitors on the market for the treatment of chronic hepatitis C genotype 1 in combination with peginterferon alpha and ribavirin. Well-documented potential adverse reactions of TPV are hematological, skin, and gastro-intestinal disorders. Until now, there were no conclusive data from clinical trials about renal adverse reactions of TPV. We report here three cases of renal impairment that occurred after a few days of TPV treatment and resolved in about 2 weeks after stopping the drug. Two of the patients were hospitalized because of this serious adverse drug reaction. Therefore, renal impairment seems to be a new adverse drug reaction of TPV and clinicians should be aware of this potentially serious complication of chronic hepatitis C therapy.
authors.affiliation: From the 1 Pharmacovigilance Center, Regional Hospital , Lugano , Switzerland.
authors.forename: Laura
authors.initials: L
authors.lastname: Andreocchi
authors.forename: Valeriu
authors.initials: V
authors.lastname: Toma
authors.forename: Aliza
authors.initials: A
authors.lastname: Canonica-Lepori
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Magenta
authors.forename: Sandor
authors.initials: S
authors.lastname: Györik
authors.forename: Lisa
authors.initials: L
authors.lastname: Pellegrini
authors.forename: Enos
authors.initials: E
authors.lastname: Bernasconi
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D019698:Hepatitis C, Chronic / Q000188:drug therapy; D006801:Humans; D008297:Male; D009842:Oligopeptides / Q000009:adverse effects* / Q000627:therapeutic use; D051437:Renal Insufficiency / Q000139:chemically induced*
chemical_list: D000998:Antiviral Agents; D009842:Oligopeptides; C486464:telaprevir; D003404:Creatinine
keywords: Telaprevir; adverse reaction; creatinine; renal impairment