title: Analysis of functional variants reveals new candidate genes associated with alexithymia.
abstract: In this study we explored the possible association between 36,915 functional variants and alexithymia, a personality trait characterized by the inability to identify and describe emotions and feelings. From our analysis, variants in the genes ABCB4, TP53AIP1, ARHGAP32 and TMEM88B were identified linked to the alexithymia phenotype.
authors.affiliation: Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" - Trieste, Italy; Department of Medical Sciences, University of Trieste, Piazza dell׳Ospitale, 1, 34125 Trieste, Italy. Electronic address: massimo.mezzavilla@burlo.trieste.it.
authors.forename: Massimo
authors.initials: M
authors.lastname: Mezzavilla
authors.affiliation: Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" - Trieste, Italy.
authors.forename: Sheila
authors.initials: S
authors.lastname: Ulivi
authors.affiliation: Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" - Trieste, Italy.
authors.forename: Martina La
authors.initials: ML
authors.lastname: Bianca
authors.affiliation: Sanatorio Triestino, via Rossetti 63, Trieste, Italy. Electronic address: davide.carlino@tiscali.it.
authors.forename: Davide
authors.initials: D
authors.lastname: Carlino
authors.affiliation: Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" - Trieste, Italy; Department of Medical Sciences, University of Trieste, Piazza dell׳Ospitale, 1, 34125 Trieste, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Gasparini
authors.affiliation: Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" - Trieste, Italy.
authors.forename: Antonietta
authors.initials: A
authors.lastname: Robino
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D000368:Aged; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D004644:Emotions; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D010555:Personality Inventory; D010641:Phenotype; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D055815:Young Adult
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; C477325:TMEM8B protein, human; C114495:TP53TG1 protein, human; D025521:Tumor Suppressor Proteins; C095122:multidrug resistance protein 3
keywords: ABCB4; Alexithymia; Functional variants