title: Flavonoids from Salvia chloroleuca with α-Amylsae and α-Glucosidase Inhibitory Effect.
abstract: It is believed that the inhibition of carbohydrate hydrolyzing enzymes including α-amylase and α-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. Medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. In our study four flavonoids, namely luteolin 7-O-glucoside (1), luteolin 7-O-glucuronide (2), diosmetin 7-O-glucuronide (3) and salvigenin (4) were isolated from aerial parts of Salvia chloroleuca. The inhibitory activity of these compounds against α-amylase and α-glucosidase were evaluated. Compounds 1, 2 and 3 showed potent α-glucosidase inhibitory effect with IC50 values of 18.3, 14.7, and 17.1 µM, respectively. Also these compounds exhibited moderate α-amylase activity with IC50 values 81.7, 61.5, and 76.3 µM, respectively.
authors.affiliation: Department of Plant Production and Breeding, Faculty of Engineering and Technology, Imam Khomeini International University, Qazvin, Iran. ; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Tehran, Iran.
authors.forename: Behvar
authors.initials: B
authors.lastname: Asghari
authors.affiliation: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Tehran, Iran.
authors.forename: Peyman
authors.initials: P
authors.lastname: Salehi
authors.affiliation: Department of Biology , Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Sonboli
authors.affiliation: Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Tehran, Iran. ; Division of Pharmaceutical Biology, University of Basel, Klingelberg Strasse 50, 4056 Basel, Switzerland.
authors.forename: Samad
authors.initials: S
authors.lastname: Nejad Ebrahimi
keywords: Enzyme inhibition; Flavonoids; Salvia chloroleuca; α-amylase; α-glucosidase