title: Brains, Blood, and Guts: MeCP2 Regulates Microglia, Monocytes, and Peripheral Macrophages.
abstract: Mutations in methyl-CpG-binding protein 2 (MECP2) underlie most cases of Rett Syndrome, a neurodevelopmental disorder with neurological and somatic impairments. In this issue of Immunity, Cronk et al. (2015) find that macrophages in MeCP2-deficient mice are abnormal in number, as well as in glucocorticoid, hypoxia, and inflammatory responses.
authors.affiliation: Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: dorothy.schafer@umassmed.edu.
authors.forename: Dorothy P
authors.initials: DP
authors.lastname: Schafer
authors.affiliation: Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.
authors.forename: Beth
authors.initials: B
authors.lastname: Stevens
mesh_terms: D000818:Animals; D018899:CpG Islands / Q000276:immunology*; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D017737:Macrophages, Peritoneal / Q000276:immunology*; D008297:Male; D051783:Methyl-CpG-Binding Protein 2 / Q000276:immunology*; D017628:Microglia / Q000276:immunology*; D015518:Rett Syndrome / Q000276:immunology*
chemical_list: D051783:Methyl-CpG-Binding Protein 2