title: Revisiting pulmonary acinar particle transport: convection, sedimentation,  diffusion, and their interplay.
abstract: It is largely acknowledged that inhaled particles ranging from 0.001 to 10 m are able to reach and deposit in the alveolated regions of the lungs. To date, however, the bulk of numerical studies have focused mainly on micrometer sized particles whose transport kinematics are governed by convection and sedimentation, thereby capturing only a small fraction of the wider range of aerosols leading to acinar deposition. Too little is still known about the local acinar transport dynamics of inhaled (ultra)fine particles affected by diffusion and convection. Our study aims to fill this gap by numerically simulating the transport characteristics of particle sizes spanning three orders of magnitude (0.01-5 m) covering diffusive, convective, and gravitational aerosol motion across a multigenerational acinar network. By characterizing the deposition patterns as a function of particle size, we find that submicrometer particles [formulae see text (0.1 m)] reach deep into the acinar structure and are prone to deposit near alveolar openings; meanwhile, other particle sizes are restricted to accessing alveolar cavities in proximal generations. Our findings underline that a precise understanding of acinar aerosol transport, and ultrafine particles in particular, is contingent upon resolving the complex convective-diffusive interplay in determining their irreversible kinematics and local deposition sites.
authors.forename: Philipp
authors.initials: P
authors.lastname: Hofemeier
authors.forename: Josué
authors.initials: J
authors.lastname: Sznitman
mesh_terms: D061354:Acinar Cells / Q000378:metabolism*; D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D001692:Biological Transport; D003198:Computer Simulation; D004058:Diffusion; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D009038:Motion; D009716:Numerical Analysis, Computer-Assisted; D010316:Particle Size; D011650:Pulmonary Alveoli / Q000166:cytology / Q000378:metabolism*
chemical_list: D000336:Aerosols