title: Generation of cycloheptynes and cyclooctynes via a sulfoxide-magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates.
abstract: Cycloheptynes and cyclooctynes were efficiently generated via a sulfoxide-magnesium exchange reaction of readily synthesized 2-sulfinylcycloalkenyl triflates. Cycloadditions between various ynophiles and the cycloalkynes generated by this method proceeded efficiently, providing an easy method to prepare a wide range of heterocycles fused with seven- or eight-membered carbocycles.
authors.affiliation: Laboratory of Chemical Bioscience, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. thosoya.cb@tmd.ac.jp.
authors.forename: Suguru
authors.initials: S
authors.lastname: Yoshida
authors.forename: Fumika
authors.initials: F
authors.lastname: Karaki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Uchida
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Hosoya
mesh_terms: D003500:Cyclization; D003516:Cycloparaffins / Q000138:chemical synthesis* / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D008698:Mesylates / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013454:Sulfoxides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D003516:Cycloparaffins; D008698:Mesylates; D013454:Sulfoxides; D008274:Magnesium