title: Surgical experience of adult primary hepatic sarcomas.
abstract: BACKGROUND
  Primary hepatic sarcoma (PHS) is a rare primary liver malignancy. The histological types of PHS are diverse, and the clinical outcomes and management mainly depend on the histopathology. This study aims to evaluate the results of surgical intervention.
  
  
  METHODS
  Between January 2003 and June 2009, 13 adult patients with pathologically proven PHS were identified by record review. The patients' demographic profile, tumor characteristics, treatment modalities, and outcomes were reviewed and analyzed. The end of follow-up was December 2014.
  
  
  RESULTS
  Nine (69%) underwent curative liver resection and two underwent liver transplantation; the others received non-operative treatments. The pathologic findings were six (46%) angiosarcomas, four (30.7%) undifferentiated sarcomas, one (7.6%) leiomyosarcoma, one (7.6%) malignant mesenchymoma, and one (7.6%) hepatic epithelioid hemangioendothelioma. The median follow-up was 31.4 (2.8 ~ 142.5) months. The 1-, 2-, and 5-year survival of surgical patients were 72.7%, 63.6%, and 36.4%, respectively. Importantly, the 1-, 2-, and 5-year survival rates of non-angiosarcoma patients were superior to those of angiosarcoma (85.7% vs. 33.3%, 71.4% vs. 16.7%, and 57.1% vs. 0%, respectively, P = 0.023).
  
  
  CONCLUSIONS
  Surgical intervention provides the possibility of long-term survival from PHS. Angiosarcoma is associated with a more dismal outcome than non-angiosarcoma.
authors.affiliation: Department of Surgery of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung, Kaohsiung, 83301, Taiwan. adrianlin107@gmail.com.
authors.forename: Yu-Hung
authors.initials: YH
authors.lastname: Lin
authors.affiliation: Department of Surgery of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung, Kaohsiung, 83301, Taiwan. immunologylin@gmail.com.
authors.forename: Chih-Che
authors.initials: CC
authors.lastname: Lin
authors.affiliation: Department of Surgery of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung, Kaohsiung, 83301, Taiwan. allanc_md@yahoo.com.
authors.forename: Allan M
authors.initials: AM
authors.lastname: Concejero
authors.affiliation: Department of Surgery of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung, Kaohsiung, 83301, Taiwan. yong3980@hotmail.com.
authors.forename: Chee-Chien
authors.initials: CC
authors.lastname: Yong
authors.affiliation: Department of Pathology of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, 83301, Taiwan. kuofy@cgmh.org.tw.
authors.forename: Fang-Ying
authors.initials: FY
authors.lastname: Kuo
authors.affiliation: Department of Surgery of Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Da-Pei Road, Niao-Sung, Kaohsiung, 83301, Taiwan. ufel4996@gmail.com.
authors.forename: Chih-Chi
authors.initials: CC
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006394:Hemangiosarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007890:Leiomyosarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008637:Mesenchymoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult