title: A green synthetic approach to the synthesis of Schiff bases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile as potential anti-inflammatory agents.
abstract: A green, novel, rapid, and efficient protocol is developed for the synthesis of various Schiffbases from 4-amino-2-thioxo-1,3-diazaspiro[5.5]undec-4-ene-5-carbonitrile using ammonium chloride as a very inexpensive and readily available reagent in refluxing ethanol. High yields, easy work-up, and short reaction times are advantages of this environmentally benign procedure. The prepared compounds were screened for their anti-inflammatory activity "at a dose of 10 mg/kg body weight", which revealed promising activities relative to indomethacin used as a reference standard in this study.
authors.forename: Sh A
authors.initials: ShA
authors.lastname: Abdel-Mohsen
authors.forename: E M
authors.initials: EM
authors.lastname: Hussein
mesh_terms: D000643:Ammonium Chloride / Q000737:chemistry; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D001372:Aza Compounds; D009570:Nitriles; D012545:Schiff Bases; D000643:Ammonium Chloride