title: Common adverse events associated with ribavirin therapy for Severe Fever with Thrombocytopenia Syndrome.
abstract: Severe Fever with Thrombocytopenia Syndrome (SFTS) is associated with high mortality rate, for which antiviral therapy with ribavirin was recommended. Based on our previous study, no visible effect of ribavirin therapy in improving clinical outcome was observed. Here we have accumulated the sample size to 634, and by performing prospective observation on the clinical progress and laboratory parameters, we found a significantly higher incidence of anemia and hyperamylasemia in patients who received ribavirin therapy in comparison with those who received no therapy. Generalized estimating equation model disclosed a significant effect on hemoglobin reduction and blood amylase augmentation from ribavirin administration. The occurrence of anemia and hyperamylasemia was associated with SFTS patients receiving ribavirin therapy, which might be adverse event of this drug administration. The recommendation of ribavirin for treating SFTS should be applied with caution.
authors.affiliation: School of Public Health, Peking University, Beijing 100191, PR China. Electronic address: qingbinlu@bjmu.edu.cn.
authors.forename: Qing-Bin
authors.initials: QB
authors.lastname: Lu
authors.affiliation: Department of Clinical Laboratory, General Hospital of Beijing Military Region, Beijing 100700, PR China. Electronic address: zhangshuyan0719@163.com.
authors.forename: Shu-Yan
authors.initials: SY
authors.lastname: Zhang
authors.affiliation: The 154 Hospital, People's Liberation Army, Xinyang 464000, PR China. Electronic address: cnblcc@sohu.com.
authors.forename: Ning
authors.initials: N
authors.lastname: Cui
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China. Electronic address: hujiangong110@126.com.
authors.forename: Jian-Gong
authors.initials: JG
authors.lastname: Hu
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China. Electronic address: 415529141@qq.com.
authors.forename: Ya-Di
authors.initials: YD
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China; Graduate School of Anhui Medical University, Hefei 230032, PR China. Electronic address: gctedison@163.com.
authors.forename: Chen-Tao
authors.initials: CT
authors.lastname: Guo
authors.affiliation: The 154 Hospital, People's Liberation Army, Xinyang 464000, PR China. Electronic address: qinshuli154@126.com.
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Qin
authors.affiliation: The 154 Hospital, People's Liberation Army, Xinyang 464000, PR China. Electronic address: yzd57906@shan.com.
authors.forename: Zhen-Dong
authors.initials: ZD
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China; Graduate School of Anhui Medical University, Hefei 230032, PR China. Electronic address: 1045643573@qq.com.
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China; Graduate School of Anhui Medical University, Hefei 230032, PR China. Electronic address: 117935354@qq.com.
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China. Electronic address: babylovehopi@163.com.
authors.forename: Xiao-Ai
authors.initials: XA
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China. Electronic address: lwbime@163.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, PR China. Electronic address: caowc@bmi.ac.cn.
authors.forename: Wu-Chun
authors.initials: WC
authors.lastname: Cao
mesh_terms: D000740:Anemia / Q000209:etiology; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D034321:Hyperamylasemia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010217:Phlebotomus Fever / Q000188:drug therapy* / Q000821:virology; D016856:Phlebovirus / Q000187:drug effects; D011446:Prospective Studies; D012254:Ribavirin / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D006454:Hemoglobins; D012254:Ribavirin
keywords: Adverse event; Hyperamylasemia; Ribavirin; Severe Fever with Thrombocytopenia Syndrome