title: The burden of nosocomial staphylococcus aureus bloodstream infection in South Korea: a prospective hospital-based nationwide study.
abstract: BACKGROUND
  We estimated the nationwide burden of nosocomial S. aureus bloodstream infection (SA-BSI), a major cause of nosocomial infection, in South Korea.
  
  
  METHODS
  To evaluate the nationwide incidence of nosocomial SA-BSI, cases of SA-BSI were prospectively collected from 22 hospitals with over 500 beds over 4?months. Data on patient-days were obtained from a national health insurance database containing the claims data for all healthcare facilities in South Korea. The additional cost of SA-BSI was estimated through a matched case?control study. The economic burden was calculated from the sum of the medical costs, the costs of caregiving and loss of productivity.
  
  
  RESULTS
  Three hundred and thirty nine cases of nosocomial SA-BSI were included in the study: 254 cases of methicillin-resistant SA-BSI (MRSA-BSI) and 85 cases of methicillin-susceptible SA-BSI (MSSA-BSI). Death related to BSI occurred in 81 cases (31.9%) of MRSA-BSI and 12 cases (14.1%) of MSSA-BSI. The estimated incidence of nosocomial MRSA-BSI was 0.12/1,000 patient-days and that of nosocomial MSSA-BSI, 0.04/1,000 patient-days. The estimated annual cases of nosocomial BSI were 2,946 for MRSA and 986 for MSSA in South Korea. The additional economic burden per case of nosocomial SA-BSI was US $20,494 for MRSA-BSI and $6,914 for MSSA-BSI. Total additional annual cost of nosocomial SA-BSI was $67,192,559.
  
  
  CONCLUSIONS
  In view of the burden of nosocomial SA-BSI, a national strategy for reducing nosocomial SA-BSI is urgently needed in South Korea.
authors.forename: Chung-Jong
authors.initials: CJ
authors.lastname: Kim
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Kim
authors.forename: Myoung-don
authors.initials: MD
authors.lastname: Oh
authors.forename: Yunhee
authors.initials: Y
authors.lastname: Kim
authors.forename: Arim
authors.initials: A
authors.lastname: Kim
authors.forename: Sung-Hee
authors.initials: SH
authors.lastname: Oh
authors.forename: Kyoung-Ho
authors.initials: KH
authors.lastname: Song
authors.forename: Eu
authors.initials: E
authors.lastname: Kim
authors.forename: Yong
authors.initials: Y
authors.lastname: Cho
authors.forename: Young
authors.initials: Y
authors.lastname: Choi
authors.forename: Jinyong
authors.initials: J
authors.lastname: Park
authors.forename: Baek-Nam
authors.initials: BN
authors.lastname: Kim
authors.forename: Nam-Joong
authors.initials: NJ
authors.lastname: Kim
authors.forename: Kye-Hyung
authors.initials: KH
authors.lastname: Kim
authors.forename: Eun
authors.initials: E
authors.lastname: Lee
authors.forename: Jae-Bum
authors.initials: JB
authors.lastname: Jun
authors.forename: Young
authors.initials: Y
authors.lastname: Kim
authors.forename: Sung
authors.initials: S
authors.lastname: Kiem
authors.forename: Hee
authors.initials: H
authors.lastname: Choi
authors.forename: Eun
authors.initials: E
authors.lastname: Choo
authors.forename: Kyung-Mok
authors.initials: KM
authors.lastname: Sohn
authors.forename: Shinwon
authors.initials: S
authors.lastname: Lee
authors.forename: Hyun
authors.initials: H
authors.lastname: Chang
authors.forename: Ji
authors.initials: J
authors.lastname: Bang
authors.forename: Su
authors.initials: S
authors.lastname: Lee
authors.forename: Jae
authors.initials: J
authors.lastname: Lee
authors.forename: Seong
authors.initials: S
authors.lastname: Park
authors.forename: Min
authors.initials: M
authors.lastname: Jeon
authors.forename: Na
authors.initials: N
authors.lastname: Yun
mesh_terms: D000368:Aged; D016470:Bacteremia / Q000453:epidemiology*; D016022:Case-Control Studies; D017281:Cost of Illness; D003428:Cross Infection / Q000453:epidemiology*; D016208:Databases, Factual; D005260:Female; D006761:Hospitals; D006801:Humans; D015994:Incidence; D008297:Male; D016106:Methicillin Resistance; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*