title: Sorafenib in the treatment of recurrent hepatocellular carcinoma after liver transplantation: a report of four cases.
abstract: With an increasing number of patients with hepatocellular carcinoma (HCC) undergoing liver transplantation (LT), tumor recurrence remains the main limiting factor for long-term survival. Although sorafenib is available for advanced HCC, there is still a lack of data on the use of sorafenib for treatment of recurrent HCC after LT. Here, we report on four cases of the use of sorafenib for treatment of recurrent HCC after LT. The median time of recurrence from LT was 4 months (range, 1-16 months). Two of the four evaluated patients showed stable disease, which was the best response and the duration of stabilization was 11 months and 5 months, respectively. One patient also experienced stable disease and remained in stable disease without sorafenib therapy for 29 months and the total duration of stabilization was 38 months. The remaining patient showed partial response but stopped treatment due to radiological tumor progression during treatment. Although all cases were high risk group for recurrence such as above Milan criteria, vascular invasion and tumor biology, clinical outcomes showed some good results. Therefore, sorafenib may be an acceptable treatment option for recurrent HCC after LT.
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Hong
authors.forename: Ki Tae
authors.initials: KT
authors.lastname: Yoon
authors.forename: Mong
authors.initials: M
authors.lastname: Cho
authors.forename: Dae Hwan
authors.initials: DH
authors.lastname: Kang
authors.forename: Hyung Wook
authors.initials: HW
authors.lastname: Kim
authors.forename: Cheol Woong
authors.initials: CW
authors.lastname: Choi
authors.forename: Su Bum
authors.initials: SB
authors.lastname: Park
authors.forename: Jeong
authors.initials: J
authors.lastname: Heo
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Woo
authors.forename: Won
authors.initials: W
authors.lastname: Lim
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010671:Phenylurea Compounds / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D000077157:Sorafenib; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D009536:Niacinamide; D000077157:Sorafenib
keywords: Hepatocellular carcinoma; Liver transplantation; Recurrence; Sorafenib