title: Recipient factors associated with having a potential living donor for liver transplantation.
abstract: Because of a persistent discrepancy between the demand for liver transplantation (LT) and the supply of deceased donor organs, there is an interest in increasing living donation rates at centers trained in this method of transplantation. We examined a large socioeconomically heterogeneous cohort of patients listed for LT to identify recipient factors associated with living donation. We retrospectively reviewed 491 consecutive patients who were listed for LT at our center over a 24-month period. Demographic, medical, and socioeconomic data were extracted from electronic records and compared between those who had a potential living donor (LD) volunteer for assessment and those who did not; 245 patients (50%) had at least 1 potential LD volunteer for assessment. Multivariate logistic regression analysis identified that patients with a LD were more likely to have Child-Pugh C disease (odds ratio [OR], 2.44; P = 0.02), and less likely to be older (OR, 0.96; P = 0.002), single (OR, 0.34; P = 0.006), divorced (OR, 0.53; P = 0.03), immigrants (OR, 0.38; P = 0.049), or from the lowest income quintile (OR, 0.44; P = 0.02). In conclusion, this analysis has identified several factors associated with access to living donation. More research is warranted to define and overcome barriers to living donor liver transplantation through targeted interventions in underrepresented populations.
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Adam
authors.initials: A
authors.lastname: Doyle
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.|Department of Medicine, Southlake Regional Health Centre, Newmarket, ON, Canada.
authors.forename: Rania N
authors.initials: RN
authors.lastname: Rabie
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Arastoo
authors.initials: A
authors.lastname: Mokhtari
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Cattral
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Anand
authors.initials: A
authors.lastname: Ghanekar
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Grant
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Greig
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Gary
authors.initials: G
authors.lastname: Levy
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Leslie
authors.initials: L
authors.lastname: Lilly
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Ian
authors.initials: I
authors.lastname: McGilvray
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Markus
authors.initials: M
authors.lastname: Selzner
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Nazia
authors.initials: N
authors.lastname: Selzner
authors.affiliation: Liver Transplant Program/Multi-Organ Transplant Program, University Health Network, Toronto General Hospital, Toronto, ON, Canada.
authors.forename: Eberhard L
authors.initials: EL
authors.lastname: Renner
mesh_terms: D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000601:surgery; D002779:Cholestasis / Q000601:surgery; D003625:Data Collection; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000601:surgery; D017093:Liver Failure / Q000191:economics / Q000453:epidemiology / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009656:North America; D016017:Odds Ratio; D018579:Patient Selection; D012189:Retrospective Studies; D012923:Social Class; D011795:Surveys and Questionnaires