title: Synthesis of somenew hybride molecules containing several azole moieties and investigation of their biological activities.
abstract: 1,2,4-Triazole-3-one prepared from tryptamine was converted to the corresponding carbotioamides by several steps. Their treatment with ethyl bromoacetate or 4-chlorophenacyl bromide produced the corresponding 5-oxo-1,3-thiazolidine or 3-(4-chlorophenyl)-1,3-thiazole derivatives. Acetohydrazide derivative that was obtained starting from tryptamine, was converted to the corresponding Schiff basis and sulfonamide by the treatment with suitable aldehydes and benzensulphonyl chloride, respectively. 2-[(4-Amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-3-yl)methyl]-4-[2-(1H-indole-3-yl)ethyl]-5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-one was synthesized starting from hydrazide via the formation of the corresponding 1,3,4-oxadiazole compound, while the other bitriazole compounds were obtained by intramolecular cyclisation of carbothioamides in basic media. The treatment of 1,2,4-triazole or 1,3,4-oxadiazole compound with several amines generated the corresponding Mannich bases. Ethyl (2-amino-1,3-thiazole-4-yl)acetate was converted to the corresponding 1,3,4-oxadiazole derivative, arylidenehydrazides, 1,2,4-triazole-3-one and 5-oxo-1,3-oxazolidine derivatives by several steps. The structural assignments of new compounds were based on their elemental analysis and spectral (FT IR, 1H NMR, 13C NMR and LC-MS) data. The antimicrobial, antilipase and antiurease activity studies revealed that some of the synthesized compounds showed antimicrobial, antilipase and/or antiurease activity.
authors.forename: Sule
authors.initials: S
authors.lastname: Ceylan
authors.forename: Hacer
authors.initials: H
authors.lastname: Bayrak
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirbas
authors.forename: Serdar
authors.initials: S
authors.lastname: Ulker
authors.forename: Sengul
authors.initials: S
authors.lastname: Alpay-Karaoglu
authors.forename: Neslihan
authors.initials: N
authors.lastname: Demirbas
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D008049:Lipase / Q000037:antagonists & inhibitors; D008352:Mannich Bases / Q000138:chemical synthesis / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014510:Urease / Q000037:antagonists & inhibitors
chemical_list: D000890:Anti-Infective Agents; D008352:Mannich Bases; D010069:Oxadiazoles; D014230:Triazoles; C583463:1,3,4-oxadiazole; C045575:1,2,4-triazole; D008049:Lipase; D014510:Urease