title: Effect of 10-Week Supervised Moderate-Intensity Intermittent vs. Continuous Aerobic Exercise Programs on Vascular Adhesion Molecules in Patients with Heart Failure.
abstract: OBJECTIVE
  Abnormal expression of cellular adhesion molecules may be related to endothelial dysfunction, a key feature in chronic heart failure. This study compares the effects of 10-wk supervised moderate-intensity continuous aerobic exercise (CAE) and intermittent aerobic exercise (IAE) programs on markers of endothelial damage, disease severity, functional and metabolic status, and quality-of-life in chronic heart failure patients.
  
  
  METHODS
  Fifty-seven patients between 41 and 81 yrs with New York Heart Association class II-III chronic heart failure and with a left ventricular ejection fraction of 35%-55% were randomized into three groups: nonexercising control, CAE, and IAE, which exercised three times a week for 10 wks. Endothelial damage was assessed by serum markers of vascular cell adhesion molecule-1, serum intercellular adhesion molecule-1, and nitric oxide; disease severity was measured by left ventricular ejection fraction and N-terminal probrain natriuretic peptide; metabolic status was evaluated by body composition analysis and lipid profile levels; functional status was evaluated by cardiorespiratory exercise stress test and 6-min walking distance; quality-of-life was assessed with Left Ventricular Dysfunction-36 and Short-Form 36 questionnaires at the baseline and at the end of the 10th week.
  
  
  RESULTS
  Significant decreases in serum vascular cell adhesion molecule-1 or serum intercellular adhesion molecule-1 in IAE and CAE groups after training were found, respectively. Resting systolic and diastolic blood pressure, peak systolic and diastolic blood pressure, 6-min walking distance, and the mental health and vitality components of Short-Form 36 improved in the CAE group, whereas left ventricular ejection fraction and 6-min walking distance improved in the IAE group compared with the control group.
  
  
  CONCLUSIONS
  Both moderate-intensity CAE and IAE programs significantly reduced serum markers of adhesion molecules and prevented the change in VO2 in patients with chronic heart failure.
authors.affiliation: From the Departments of Physical Medicine and Rehabilitation (SA, GF, FA), Biochemistry (SR), and Cardiology (DD), Faculty of Medicine, University of Pamukkale, Denizli, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Aksoy
authors.forename: Gulin
authors.initials: G
authors.lastname: Findikoglu
authors.forename: Fusun
authors.initials: F
authors.lastname: Ardic
authors.forename: Simin
authors.initials: S
authors.lastname: Rota
authors.forename: Dursun
authors.initials: D
authors.lastname: Dursunoglu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D015815:Cell Adhesion Molecules / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology / Q000534:rehabilitation*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011446:Prospective Studies; D011788:Quality of Life; D013318:Stroke Volume / Q000502:physiology; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D015815:Cell Adhesion Molecules; D010446:Peptide Fragments; D019010:Vascular Cell Adhesion Molecule-1; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D018799:Intercellular Adhesion Molecule-1; D009569:Nitric Oxide