title: [Dynamic changes of sciatic nerve conduction velocity in rats infected with Toxoplasma gondii].
abstract: OBJECTIVE
  To observe the dynamic changes of sciatic nerve conduction velocity of Toxoplasma gondii-infected rats at different time points.
  
  
  METHODS
  Twenty SD rats were randomly divided into control group and Toxoplasma gondii infection group. Rats in T. gondii infection group were intraperitoneal injected with 4x10(7) T. gondii tachyzoites, while those in control group were given equivalent normal saline. Motor and sensory nerve conduction velocities (MNCV, SNCV) in sciatic nerve were measured by Medtronic Keypoint4 Workstation electromyography at pre-infection, and 2, 4, 8, 12 months post-infection.
  
  
  RESULTS
  Within two months after infection, there was no difference in SNCV and MNCV between control group and infection group (P>0.05). From 4 months after T. gondii injection, infected rats began to show the slowness of SNCV and MNCV, which progressed with the course of infection. At 4, 8, and 12 months after infection, SNCV and MNCV of infection group were (35.26±3.02) and (25.94±3.20) m/s, (33.57±2.27) and (22.75±2.31) m/s, and (32.38±2.38) and (22.03±2.08) m/s, respectively. Compared with control group, SNCV and MNCV of infection group reduced by (7.47±2.11)% and (12.57±1.89)%, (8.92±2.64)% and (13.72±2.65)%, and (12.18±1.94)% and (15.46±2.37)%, respectively (P<0.05).
  
  
  CONCLUSIONS
  From 4 months after infection, Toxoplasma gondii-infected rats show a slowness of motor and sensory nerve conduction velocities in sciatic nerve.
authors.forename: Yong-hua
authors.initials: YH
authors.lastname: Zhou
authors.forename: Jun-feng
authors.initials: JF
authors.lastname: Yang
authors.forename: Yong-liang
authors.initials: YL
authors.lastname: Xu
authors.forename: Yu-han
authors.initials: YH
authors.lastname: Yin
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiao-lin
authors.initials: XL
authors.lastname: Gu
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D009431:Neural Conduction; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve; D014122:Toxoplasma; D014123:Toxoplasmosis