title: A genetically informed study of the longitudinal relation between irritability and anxious/depressed symptoms.
abstract: OBJECTIVE
  Little is known about the longitudinal genetic and environmental association between juvenile irritability and symptoms of anxiety and depression. This study's goal was to assess the relationship between these constructs across a critical developmental period spanning childhood to young adulthood.
  
  
  METHODS
  Parents (n = 1,348 twin pairs) from the Swedish Twin Study of Child and Adolescent Development completed the Child/Adult Behavior Checklist (CBCL/ABCL) about their twin children. Data were collected during a prospective, 4-wave study starting in childhood (ages 8-9 years) and ending in young adulthood (ages 19-20 years). An irritability score and an anxious/depressed score were computed from CBCL/ABCL item endorsements. Genetically informative cross-lagged models were used to estimate the genetic and environmental relationship between these 2 constructs across time.
  
  
  RESULTS
  Our models suggested that irritability more strongly predicted anxious/depressed symptoms than vice versa, consistent with a causal role of irritability on anxiety/depression at older ages. This relationship was significant only in late childhood/early adolescence. Additive genetic and unique environmental factors were significant contributors to both irritability and anxious/depressed symptoms and were both specific to and shared between these 2 constructs. The same common environmental factors influenced both constructs, although these factors accounted for a smaller amount of variance than genetic or unique environmental factors.
  
  
  CONCLUSIONS
  This study adds to our understanding of the developmental relationship between irritability and anxious/depressed symptoms and the contribution of genes and environmental factors to their association across development. Findings suggest the need to monitor for emergence of internalizing symptoms in irritable children and their potential need for therapeutic intervention.
authors.affiliation: Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Savage
authors.affiliation: Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA.
authors.forename: Brad
authors.initials: B
authors.lastname: Verhulst
authors.affiliation: Duke University Medical Center, Center for Developmental Epidemiology, Durham, NC.
authors.forename: William
authors.initials: W
authors.lastname: Copeland
authors.affiliation: University of Vermont, Burlington, VT.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Althoff
authors.affiliation: Karolinska Institutet, Stockholm.
authors.forename: Paul
authors.initials: P
authors.lastname: Lichtenstein
authors.affiliation: Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA. Electronic address: rrobersonnay@vcu.edu.
authors.forename: Roxann
authors.initials: R
authors.lastname: Roberson-Nay
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001007:Anxiety / Q000175:diagnosis / Q000235:genetics*; D000067290:Behavior Rating Scale; D002648:Child; D003863:Depression / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D007508:Irritable Mood; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D013548:Sweden; D014430:Twins, Monozygotic; D055815:Young Adult
keywords: anxiety; depression; genetic; irritability; twins