title: Nanosized ZSM-5 will improve photodynamic therapy using Methylene blue.
abstract: Nowadays, nanotechnology is growing to improve Photodynamic Therapy and reduce its side effects. In this research, the synthesized co-polymeric Zeolite Secony Mobile-5 (ZSM-5) was employed to modify Methylene Blue (MB) for these reasons. UV-Visible, FTIR, XRD analysis and SEM images were used to investigate obtained nanostructure. The crystal size for these nanostructures were determined 75 nm and maximum adsorption capacity of MB in the nanostructure was estimated 111 (mg g(-1)). Also, the role of Polyethylene Glycol (PEG) was studied as a capable non-toxic polymeric coating to overcome biological barriers. Moreover, potential of singlet oxygen production of the synthesized nanostructure was compared with MB and ZSM-5 nanoparticles control samples. Synthesized nanodrugs show impressive light induced singlet oxygen production efficiency.
authors.affiliation: Department of Physics, Basic Science Faculty, Babol University of Technology, P.O. Box 47148-71167, Babol, Iran. Electronic address: kariminezhad@nit.ac.ir.
authors.forename: H
authors.initials: H
authors.lastname: Kariminezhad
authors.affiliation: Department of Physics, Basic Science Faculty, Babol University of Technology, P.O. Box 47148-71167, Babol, Iran; Mohammadreza Harriri Science Foundation, Modarres Av., Babol, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Habibi
authors.affiliation: Department of Chemical Engineering, Babol University of Technology, Babol, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Mirzababayi
mesh_terms: D008027:Light; D008751:Methylene Blue / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D026082:Singlet Oxygen / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D017641:Zeolites / Q000737:chemistry*
chemical_list: C570564:ZSM-5 zeolite; D017641:Zeolites; D026082:Singlet Oxygen; D011092:Polyethylene Glycols; D008751:Methylene Blue