title: Breast cancer associated with neurofibromatosis type 1: a case series and review of the literature.
abstract: BACKGROUND
  Neurofibromatosis type 1, also known as Von Recklinghausen's disease, is a rare neuroectodermal disease that mainly affects the skin and the nervous system. Patients with neurofibromatosis type 1 have a higher risk of developing various types of cancers, especially tumors derived from the embryogenic neural crest. However, its association with breast cancer has seldom been reported.
  
  
  METHODS
  We report the cases of three white Arabic women diagnosed with neurofibromatosis type 1, with a median age of 40-years-old (range: 39 to 43), who sought treatment at our centre for breast cancer.
  
  
  CONCLUSIONS
  The association between neurofibromatosis type 1 and breast cancer is uncommon. In our case series we readdress this association through a literature review.
authors.affiliation: Radiation Therapy Department, National Cancer Institute, Rabat, Morocco. Jihane.khalil@gmail.com.
authors.forename: Jihane
authors.initials: J
authors.lastname: Khalil
authors.affiliation: Radiation Therapy Department, National Cancer Institute, Rabat, Morocco. afifmed@hotmail.com.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Afif
authors.affiliation: Radiation Therapy Department, National Cancer Institute, Rabat, Morocco. elkacemihanan@yahoo.fr.
authors.forename: Hanan
authors.initials: H
authors.lastname: Elkacemi
authors.affiliation: Radiation Therapy Department, National Cancer Institute, Rabat, Morocco. mery-ben23@hotmail.com.
authors.forename: Meryem
authors.initials: M
authors.lastname: Benoulaid
authors.affiliation: Radiation Therapy Department, National Cancer Institute, Rabat, Morocco. kebdani2000@yahoo.fr.
authors.forename: Tayeb
authors.initials: T
authors.lastname: Kebdani
authors.affiliation: Radiation Therapy Department, National Cancer Institute, Rabat, Morocco. n.benjaafar@um5s.net.ma.
authors.forename: Noureddine
authors.initials: N
authors.lastname: Benjaafar
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000209:etiology* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000150:complications*