title: It's Never over until It's over: How Can Age and Ovarian Reserve Be Mathematically Bound through the Measurement of Serum AMH-A Study of 5069 Romanian Women.
abstract: Wide regional differences in the age-related Anti Mullerian hormone (AMH) regression patterns or age at onset of natural menopause have been reported, possibly reflecting genetic, socioeconomic, environmental, racial or ethnic peculiarities. Moreover, adaptation of AMH levels from different assays using regression functions may lack accuracy and externally defined references for AMH levels may not fully comply with a specific geographical area. The current study aimed to establish an accurate mathematical relationship between AMH serum values and age in a large group of women from Romania, as any consistent difference from previously reported regression models may aid in building specific profiles for the AMH decline with age in this geographical region. Our study pointed out to the quadratic regression as the most fitted pattern of correlation for all the age groups between 24 and 45. To our knowledge the current manuscript is based on the singular study carried out in this geographical region, generating a particular age-related pattern of association between age and serum AMH levels in women, regardless of their subjacent pathologies.
authors.affiliation: Obstetrics and Gynecology Department, Gr. T. Popa University of Medicine and Pharmacy, Iasi, Romania; Origyn Fertility Center, Iasi, Romania.
authors.forename: Bogdan
authors.initials: B
authors.lastname: Doroftei
authors.affiliation: Synevo Central Laboratory-Medicover Group, Bucuresti, Romania.
authors.forename: Cristina
authors.initials: C
authors.lastname: Mambet
authors.affiliation: Origyn Fertility Center, Iasi, Romania; Laboratory of Molecular Biology, Regional Institute of Oncology, Iasi, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Zlei
mesh_terms: D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D006801:Humans; D008593:Menopause / Q000097:blood / Q000502:physiology; D008875:Middle Aged; D065851:Ovarian Reserve / Q000502:physiology*; D012383:Romania; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone