title: Nonuniform sampling of hypercomplex multidimensional NMR experiments: Dimensionality, quadrature phase and randomization.
abstract: Nonuniform sampling (NUS) in multidimensional NMR permits the exploration of higher dimensional experiments and longer evolution times than the Nyquist Theorem practically allows for uniformly sampled experiments. However, the spectra of NUS data include sampling-induced artifacts and may be subject to distortions imposed by sparse data reconstruction techniques, issues not encountered with the discrete Fourier transform (DFT) applied to uniformly sampled data. The characterization of these NUS-induced artifacts allows for more informed sample schedule design and improved spectral quality. The DFT-Convolution Theorem, via the point-spread function (PSF) for a given sampling scheme, provides a useful framework for exploring the nature of NUS sampling artifacts. In this work, we analyze the PSFs for a set of specially constructed NUS schemes to quantify the interplay between randomization and dimensionality for reducing artifacts relative to uniformly undersampled controls. In particular, we find a synergistic relationship between the indirect time dimensions and the "quadrature phase dimension" (i.e. the hypercomplex components collected for quadrature detection). The quadrature phase dimension provides additional degrees of freedom that enable partial-component NUS (collecting a subset of quadrature components) to further reduce sampling-induced aliases relative to traditional full-component NUS (collecting all quadrature components). The efficacy of artifact reduction is exponentially related to the dimensionality of the sample space. Our results quantify the utility of partial-component NUS as an additional means for introducing decoherence into sampling schemes and reducing sampling artifacts in high dimensional experiments.
authors.affiliation: Department of Molecular Biology and Biophysics, UConn Health, 263 Farmington Avenue, Farmington, CT 06030-3305, USA. Electronic address: schuyler@uchc.edu.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Schuyler
authors.affiliation: Department of Molecular Biology and Biophysics, UConn Health, 263 Farmington Avenue, Farmington, CT 06030-3305, USA.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Maciejewski
authors.affiliation: Rowland Institute at Harvard, 100 Edwin H. Land Boulevard, Cambridge, MA 02142, USA.
authors.forename: Alan S
authors.initials: AS
authors.lastname: Stern
authors.affiliation: Department of Molecular Biology and Biophysics, UConn Health, 263 Farmington Avenue, Farmington, CT 06030-3305, USA. Electronic address: hoch@uchc.edu.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Hoch
mesh_terms: D000465:Algorithms; D016477:Artifacts; D005583:Fourier Analysis; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*
keywords: Aliasing; Compressed sensing; Discrete Fourier transform (DFT); Partial-component NUS; Point-spread function (PSF)