title: Type 2 diabetes mellitus and microvascular complications 1 year after Roux-en-Y gastric bypass: a case-control study.
abstract: OBJECTIVE
  We aimed to examine the effects of bariatric surgery on microvascular complications in patients with type 2 diabetes using objective measures.
  
  
  METHODS
  Prospective case-control study of 70 obese surgical patients with type 2 diabetes undergoing gastric bypass surgery matched for age, sex and duration of diabetes to 25 medical patients treated using international guidelines. Microvascular complications were assessed before and 12-18 months after intervention using urine albumin creatinine ratio (ACR) measurements, two-field digital retinal images and peripheral nerve conduction studies (in the surgical group only).
  
  
  RESULTS
  Urine ACR decreased significantly in the surgical group but increased in the medical group. There were no significant differences between the surgical and medical groups in the changes in retinopathy. There were no changes in the nerve conduction variables in the surgical group.
  
  
  CONCLUSIONS
  In the short term, bariatric surgery may be superior to medical care in the treatment of diabetic nephropathy, but not retinopathy or neuropathy.
authors.affiliation: Investigative Medicine, Division of Diabetes, Endocrinology & Metabolism, Imperial College London, London, UK.
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Miras
authors.forename: Ling Ling
authors.initials: LL
authors.lastname: Chuah
authors.forename: Nofal
authors.initials: N
authors.lastname: Khalil
authors.forename: Alessia
authors.initials: A
authors.lastname: Nicotra
authors.forename: Amoolya
authors.initials: A
authors.lastname: Vusirikala
authors.forename: Najah
authors.initials: N
authors.lastname: Baqai
authors.forename: Christopher
authors.initials: C
authors.lastname: Graham
authors.forename: Saranya
authors.initials: S
authors.lastname: Ravindra
authors.forename: Gerassimos
authors.initials: G
authors.lastname: Lascaratos
authors.forename: Nick
authors.initials: N
authors.lastname: Oliver
authors.forename: Carel W
authors.initials: CW
authors.lastname: le Roux
mesh_terms: D000419:Albuminuria / Q000652:urine; D000713:Anastomosis, Roux-en-Y; D015992:Body Mass Index; D002196:Capillaries / Q000473:pathology*; D016022:Case-Control Studies; D003404:Creatinine / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control / Q000601:surgery*; D003925:Diabetic Angiopathies / Q000473:pathology / Q000517:prevention & control / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000517:prevention & control / Q000601:surgery; D003929:Diabetic Neuropathies / Q000517:prevention & control / Q000601:surgery; D003930:Diabetic Retinopathy / Q000517:prevention & control / Q000601:surgery; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D009765:Obesity / Q000601:surgery; D011446:Prospective Studies; D012171:Retinal Vessels / Q000473:pathology
chemical_list: D003404:Creatinine; D006442:Glycated Hemoglobin