title: Effects of flavone on the contractile activity of the circular smooth muscle of the rabbit middle colon in vitro.
abstract: The circular smooth muscles of the middle colon of the rabbit generate giant contractions of high amplitude and low frequency. Flavone, at various concentrations, reduces the giant contractions and the tonic contraction induced by 10 µM carbachol and 80 mM KCl. The contractions induced by dequalinium and tetraethylammonium are reduced by flavone (30 µM). At 100 µM, flavone decreases the contraction induced by 100 µM methylene blue and 1mM orthovanadate. These results suggest that flavone inhibit the giant contractions by (1) inhibition of voltage-dependent Ca(2+) channels, (2) activation of guanyl cyclase, (3) opening of K(+) channels and (4) inhibition of tyrosines kinases.
authors.affiliation: Department of Microbiology and Biochemistry, Faculty of Sciences, University Mohamed Boudiaf of M׳sila, Algeria. Electronic address: benabdallahhassiba@yahoo.com.
authors.forename: Hassiba
authors.initials: H
authors.lastname: Benabdallah
authors.affiliation: Department of Animal physiology, Faculty of Nature and Life Sciences, University Ferhat Abbes of Setif, Algeria.
authors.forename: Kamel
authors.initials: K
authors.lastname: Gharzouli
mesh_terms: D000818:Animals; D003106:Colon / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D047309:Flavones / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009924:Organ Culture Techniques; D011817:Rabbits
chemical_list: D047309:Flavones; C043562:flavone
keywords: Carbamylcholine chloride (PubChem CID: 5831); Circular smooth muscle; Colon; Dequalinium chloride (PubChem CID: 10649); Flavone; Giant contractions; Methylene blue trihydrate (PubChem CID: 104827); Nitrergic transmission; Potassium channels; Sodium orthovanadate (PubChem CID: 61671); Tetraethylammonium chloride (PubChem CID: 5946)