title: Regulation of IL-17 in atherosclerosis and related autoimmunity.
abstract: Patients with systemic autoimmune diseases exhibit a higher incidence of atherosclerosis. Conversely, hyperlipidemia has been known to accelerate autoimmune diseases in humans as well as in experimental animal. How atherosclerosis impacts autoimmunity remains poorly understood. Importantly, recent studies showed that several pro-atherogenic factors including cholesterol, oxidized low-density lipoprotein and fatty acids regulate the production of IL-17 and IL-17-promoting cytokines from innate and adaptive immune cells. Given that IL-17 is associated with a number of autoimmune diseases in humans, dissecting the mechanisms beyond the mutual regulation of pro-atherogenic factors and IL-17 might provide a novel pathophysiology between atherosclerosis and autoimmune diseases. In this review, we discuss our current understanding related to the role of pro-atherogenic factors in IL-17 production and autoimmune diseases.
authors.affiliation: Laboratory of Immune Regulation, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea.
authors.forename: Heeju
authors.initials: H
authors.lastname: Ryu
authors.affiliation: Laboratory of Immune Regulation, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address: yeonseok@snu.ac.kr.
authors.forename: Yeonseok
authors.initials: Y
authors.lastname: Chung
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000276:immunology* / Q000473:pathology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D002784:Cholesterol / Q000276:immunology*; D005227:Fatty Acids / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D008077:Lipoproteins, LDL / Q000276:immunology*
chemical_list: D005227:Fatty Acids; D020381:Interleukin-17; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D002784:Cholesterol
keywords: Autoimmunity; Hyperlipidemia; IL-17; Low-density lipoprotein; Th17 cell