title: Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.
abstract: The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans.
authors.affiliation: Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA Clinical Microbiology Laboratory, Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lamoth
authors.affiliation: Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA Clinical Microbiology Laboratory, Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA alexa011@mc.duke.edu.
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Alexander
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology; D012189:Retrospective Studies; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D006027:Glycosides; D014315:Triterpenes; D000666:Amphotericin B; C569338:ibrexafungerp; D005964:Glucosyltransferases; C040232:glucan synthase