title: Signaling mechanism of the netrin-1 receptor DCC in axon guidance.
abstract: DCC (Deleted in Colorectal Cancer) is a single-pass transmembrane protein that belongs to the immunoglobulin superfamily. It was originally identified as a prognostic tumor marker and then subsequently found to be a receptor for netrin-1. DCC plays a key role in axon guidance and also in a number of other important cellular processes. This review describes the current progress of the structural biology of DCC with an emphasis on how DCC is involved in the dual functionality of netrin-1 as a chemo-attractant as well as a repellent in axon guidance, referred to as bi-functionality. A perspective about other DCC ligands and the signaling mechanism of the cytoplasmic tail of DCC is also recapitulated.
authors.affiliation: State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, 100871, China; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
authors.forename: L
authors.initials: L
authors.lastname: Finci
authors.affiliation: State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, 100871, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: European Molecular Biology Laboratory (EMBL), Hamburg Outstation, Notkestrasse 85, 22607, Hamburg, Germany. Electronic address: r.meijers@embl-hamburg.de.
authors.forename: R
authors.initials: R
authors.lastname: Meijers
authors.affiliation: State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, 100871, China; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address: jwang@crystal.harvard.edu.
authors.forename: J-H
authors.initials: JH
authors.lastname: Wang
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D000075389:DCC Receptor; D006801:Humans; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000075389:DCC Receptor; C501909:DCC protein, human; D011956:Receptors, Cell Surface; D025521:Tumor Suppressor Proteins
keywords: Axon guidance; DCC; Netrin-1; Structure; UNC5