title: A cytoarchitecture-driven myelin model reveals area-specific signatures in human primary and secondary areas using ultra-high resolution in-vivo brain MRI.
abstract: This work presents a novel approach for modelling laminar myelin patterns in the human cortex in brain MR images on the basis of known cytoarchitecture. For the first time, it is possible to estimate intracortical contrast visible in quantitative ultra-high resolution MR images in specific primary and secondary cytoarchitectonic areas. The presented technique reveals different area-specific signatures which may help to study the spatial distribution of cortical T1 values and the distribution of cortical myelin in general. It may lead to a new discussion on the concordance of cyto- and myeloarchitectonic boundaries, given the absence of such concordance atlases. The modelled myelin patterns are quantitatively compared with data from human ultra-high resolution in-vivo 7T brain MR images (9 subjects). In the validation, the results are compared to one post-mortem brain sample and its ex-vivo MRI and histological data. Details of the analysis pipeline are provided. In the context of the increasing interest in advanced methods in brain segmentation and cortical architectural studies, the presented model helps to bridge the gap between the microanatomy revealed by classical histology and the macroanatomy visible in MRI.
authors.affiliation: Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany; Faculty of Computer Science, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany. Electronic address: dinse@cbs.mpg.de.
authors.forename: J
authors.initials: J
authors.lastname: Dinse
authors.affiliation: Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Härtwich
authors.affiliation: Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany.
authors.forename: M D
authors.initials: MD
authors.lastname: Waehnert
authors.affiliation: Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany.
authors.forename: C L
authors.initials: CL
authors.lastname: Tardif
authors.affiliation: Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Schäfer
authors.affiliation: Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Geyer
authors.affiliation: Faculty of Computer Science, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Preim
authors.affiliation: Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Turner
authors.affiliation: Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany; Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraß e 1a, 04103 Leipzig, Germany.
authors.forename: P-L
authors.initials: PL
authors.lastname: Bazin
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000166:cytology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009044:Motor Cortex / Q000166:cytology; D009186:Myelin Sheath; D013003:Somatosensory Cortex / Q000166:cytology; D055815:Young Adult
keywords: Cortical areas; Cortical profiles; Cytoarchitecture; Modelling ultra-high resolution; Myeloarchitecture; Quantitative MRI