title: Formation of controllable hydrophilic/hydrophobic drug delivery systems by electrospinning of vesicles.
abstract: Novel multifunctional poly(ethylene oxide) (PEO) nanofibrous membrane, which contains vesicles constructed by mixed surfactant cetyltrimethylammonium bromide (CTAB)/sodium dodecylbenzenesulfonate (SDBS), has been designed as dual drug-delivery system and fabricated via the electrospinning process. 5-FU and paeonolum, which are hydrophilic and hydrophobic anticancer model drugs, can be dissolved in vesicle solution's bond water and lipid bilayer membranes, respectively. The physicochemical properties of the electrospun nanofibrous membrane were systematically studied using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FTIR), and X-ray diffraction (XRD). Drug release behaviors of the electrospun nanofibrous membrane fabricated with different molar ratio of CTAB/SDBS vesicle solution were investigated. The result showed that the releasing amount of hydrophilic drug presented an ascending release manner, while the hydrophobic one showed a descending release behavior with increasing of the molar ratio of CTAB/SDBS. Moreover, the release amount of drugs from drug delivery system can be controlled by the molar ratio of CTAB/SDBS in the vesicle solution easily and conveniently. The distinct properties can be utilized to encapsulate environmental demanding and quantificational materials.
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100048, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100048, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Luo
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100048, China.
authors.forename: Yanjuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100048, China.
authors.forename: Xiuniang
authors.initials: X
authors.lastname: Tan
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing 100048, China.
authors.forename: Lifei
authors.initials: L
authors.lastname: Liu
mesh_terms: D001557:Benzenesulfonates / Q000737:chemistry; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D005472:Fluorouracil / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D011092:Polyethylene Glycols / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001557:Benzenesulfonates; D002593:Cetrimonium Compounds; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; C001114:dodecylbenzenesulfonic acid; D005472:Fluorouracil; D000077286:Cetrimonium