title: New biomolecular approaches to the treatment of glioblastoma multiforme.
abstract: The mechanisms of therapeutic resistance of human glioblastoma multiforme are analyzed. The authors make an attempt at systematization and scientific theoretical validation of new approaches to creation of biomedical cellular preparations, based on the oncoproteomic technologies, for personified therapy of the glial tumors. A new approach to the treatment of glioblastoma multiforme with due consideration for the molecular biological characteristics of the tumor stem cells is suggested. It is shown that the tumor stem cell proteome can be regarded as the main target for cell therapy.
authors.affiliation: School of Biomedicine, Far-Eastern Federal University, Vladivostok, Russia, bruhovetsky@mail.ru.
authors.forename: I S
authors.initials: IS
authors.lastname: Bryukhovetskii
authors.forename: A S
authors.initials: AS
authors.lastname: Bryukhovetskii
authors.forename: Yu S
authors.initials: YS
authors.lastname: Khotimchenko
mesh_terms: D023281:Genomics; D005909:Glioblastoma / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000378:metabolism; D040901:Proteomics; D059467:Transcriptome / Q000235:genetics