title: Inferior mesenteric artery chemoembolization and chemotherapy for advanced rectal cancer: report of a clinical case.
abstract: Patients with advanced and incurable colorectal cancer have a very poor prognosis. Curative-intent resection was performed in 70%-90% of cases in reported series of colorectal cancer, sometimes after neoadjuvant chemotherapy and radiotherapy. The remaining 10%-30% of patients are treated with palliative intent, where treatment is aimed at relieving disease-related symptoms and improving quality of life. The provision of palliative care for these patients is complicated and outcomes are often disappointing. Although there are many available options including a variety of surgical and nonsurgical interventions, the best management remains controversial. Transarterial chemoembolization with irinotecan-loaded drug-eluting beads (DEBIRI) is an effective, minimally invasive procedure performed by interventional radiologists that allows intra-arterial drug delivery to stop vascular feeding and exert local cytotoxic effects. We here report on a patient treated with DEBIRI followed by systemic chemotherapy with the FOLFOX regimen for locally advanced, inoperable colorectal cancer.
authors.affiliation: 1 General Surgery Department, SG Bosco Hospital ASL To2, Turin - Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bini
authors.forename: Simone
authors.initials: S
authors.lastname: Comelli
authors.forename: Alfredo
authors.initials: A
authors.lastname: Addeo
authors.forename: Tiziana
authors.initials: T
authors.lastname: Viora
authors.forename: Federica
authors.initials: F
authors.lastname: Vana
authors.forename: Giacomo Paolo
authors.initials: GP
authors.lastname: Vaudano
authors.forename: Daniele
authors.initials: D
authors.lastname: Savio
authors.forename: Renzo
authors.initials: R
authors.lastname: Leli
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016461:Chemoembolization, Therapeutic / Q000379:methods; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D002955:Leucovorin / Q000008:administration & dosage; D017537:Mesenteric Artery, Inferior; D008863:Microspheres; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D009944:Organoplatinum Compounds; D000077146:Irinotecan; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin