title: [Preliminary investigation on the safety and efficacy of Trabectome].
abstract: OBJECTIVE
  To evaluate the safety and efficacy of ab interno trabeculectomy (Trabectome) surgery in Chinese open angle glaucoma patients.
  
  
  METHODS
  Prospective non-comparative case series study. A total of 41 cases (34 primary open angle glaucoma patients, 3 developmental glaucoma patients and 4 pigmentary glaucoma patients) were included in the study. All the cases underwent Trabectome, including 9 cases combined with phacoemulsification cataract extraction. Major outcomes include intraocular pressure (IOP), number of glaucoma medications, secondary glaucoma surgery and postoperative complications. Criteria for successful operation were defined as IOP ≤ 21 mmHg (1 mmHg = 0.133 kPa), at least 20% IOP reduction in any two consecutive visits after 3 months with or without IOP-lowering drugs and no additional glaucoma surgery. IOP and number of glaucoma medications were compared to baseline using Wilcoxon signed-rank test with Bonferroni correction. Kaplan-Meier analysis was performed to analyze the success rate of surgery.
  
  
  RESULTS
  In the all 41 patients, 21 cases (51.2%) were followed up for up to 12 months. IOP was reduced from (22.5 ± 8.1) mmHg to (17.6 ± 6.4) mmHg (P = 0.02), meanwhile number of glaucoma medications was reduced from 2.0 ± 0.9 to 1.2 ± 0.9 (P = 0.02) at 12 months. The success rate at one year was 85% and 4 cases required additional glaucoma surgery.
  
  
  CONCLUSIONS
  Trabectome has many advantages, such as shorter surgery time, simple post-operative care, less intraoperative and postoperative complications and clear IOP-lowering effect. But it slong-term efficacy is still need a large sample, long-term follow-up to verify.
authors.affiliation: Department of Ophthalmology, Peking University Third Hospital, Key Laboratory of Vision Loss and Restoration,Ministry of Education, Beijing 100191, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Huang
authors.forename: Huaizhou
authors.initials: H
authors.lastname: Wang
authors.forename: Huijuan
authors.initials: H
authors.lastname: Wu
authors.forename: Yanran
authors.initials: Y
authors.lastname: Sun
authors.forename: Minshu
authors.initials: M
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Cui
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Qiu
authors.forename: Yiquan
authors.initials: Y
authors.lastname: Yang
authors.forename: Zeqin
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Email: zhangc1@yahoo.com.
authors.forename: Chun
authors.initials: C
authors.lastname: Zhang
authors.forename: Ningli
authors.initials: N
authors.lastname: Wang
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005901:Glaucoma / Q000628:therapy*; D005902:Glaucoma, Open-Angle / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D018918:Phacoemulsification; D011183:Postoperative Complications; D011446:Prospective Studies; D012449:Safety; D014130:Trabeculectomy / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome