title: Mechanical properties study of SW480 cells based on AFM.
abstract: Since the invention of the atomic force microscope (AFM), it has been widely applied in biomedicine. One of the most important applications is used as an indenter tool to do the indentation experiment in order to get the mechanical properties of cells. In this paper, SW480 cells were used as the test subjects. Through the analysis of the contact and indentation, Young's modulus (E), which is an important parameter of cancer cells, has been estimated. Experimental results show that different mechanical models should be chosen to calculate the E in different indentation depths. Here, the E of SW480 cells was (2.5 ± 0.8) KPa at the indentation depth of 99 nm.
authors.affiliation: International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, 7089 Weixing Road, Changchun, 130022, P. R. China.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Liu
authors.affiliation: International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, 7089 Weixing Road, Changchun, 130022, P. R. China.
authors.forename: Zhengxun
authors.initials: Z
authors.lastname: Song
authors.affiliation: International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, 7089 Weixing Road, Changchun, 130022, P. R. China.
authors.forename: Yingmin
authors.initials: Y
authors.lastname: Qu
authors.affiliation: International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, 7089 Weixing Road, Changchun, 130022, P. R. China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Wang
authors.affiliation: International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, 7089 Weixing Road, Changchun, 130022, P. R. China.
authors.forename: Zuobin
authors.initials: Z
authors.lastname: Wang
mesh_terms: D001696:Biomechanical Phenomena; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000473:pathology*; D055119:Elastic Modulus; D004548:Elasticity; D006801:Humans; D018625:Microscopy, Atomic Force / Q000379:methods*; D008962:Models, Theoretical
keywords: Atomic Force Microscope; Indentation Depth; Mechanical Models; Probe Morphology; SW480 Cell; Young's Modulus