title: Prediction of elevated left ventricular filling pressures in patients with preserved ejection fraction using longitudinal deformation indices of the left ventricle.
abstract: OBJECTIVE
  Estimation of left ventricular (LV) filling pressures is a clinical challenge in patients with preserved ejection fraction (EF). In the present study, we investigated whether LV and atrial longitudinal strain and strain rate (SR) parameters derived by speckle tracking echocardiography (STE) could be used to predict invasively measured LV end-diastolic pressure (LVEDP) in this patient population.
  
  
  RESULTS
  LVEDP was measured before coronary angiography was performed in 65 patients with preserved EF (≥50%) referred to elective cardiac catheterization; besides, patients enrolled underwent comprehensive echocardiographic examination before the procedure. In addition to conventional echocardiographic parameters used to evaluate diastolic function LV longitudinal strain and SR, as well as peak atrial longitudinal strain during LV systole, measurements were performed using STE. Only log-diastolic blood pressure, systolic SR, early diastolic SR, SR during isovolumetric relaxation (SRIVR), and mitral early diastolic flow velocity/SRIVR significantly correlated with LVEDP. When age-adjusted stepwise linear regression analysis was performed, SRIVRT values (β= -20.682, t = -3.292; P = 0.002) and log-diastolic blood pressure levels (β= 21.118, t = 3.784; P < 0.001) were independently correlated with LVEDP.
  
  
  CONCLUSIONS
  When compared with conventional echocardiographic parameters, other longitudinal strain, and SR indices, SRIVRT independently predicted LVEDP in conjunction with log diastolic blood pressure. We suggest that SRIVRT is a valuable parameter to evaluate diastolic function in patients with preserved EF.
authors.affiliation: Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Denizer Caddesi, Kartal/Istanbul 34846, Turkey suzan_hatipoglu@hotmail.com.
authors.forename: Suzan
authors.initials: S
authors.lastname: Hatipoğlu
authors.affiliation: Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Denizer Caddesi, Kartal/Istanbul 34846, Turkey.
authors.forename: Nihal
authors.initials: N
authors.lastname: Özdemir
authors.affiliation: Medipol University Hospital, Istanbul, Turkey.
authors.forename: Gamze
authors.initials: G
authors.lastname: Babür Güler
authors.affiliation: Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Denizer Caddesi, Kartal/Istanbul 34846, Turkey.
authors.forename: Ruken Bengi
authors.initials: RB
authors.lastname: Bakal
authors.affiliation: Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Denizer Caddesi, Kartal/Istanbul 34846, Turkey.
authors.forename: Cetin
authors.initials: C
authors.lastname: Geçmen
authors.affiliation: Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Denizer Caddesi, Kartal/Istanbul 34846, Turkey.
authors.forename: Özkan
authors.initials: Ö
authors.lastname: Candan
authors.affiliation: Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Denizer Caddesi, Kartal/Istanbul 34846, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Doğan
authors.affiliation: Department of Cardiology, Kartal Kosuyolu Heart Training and Research Hospital, Denizer Caddesi, Kartal/Istanbul 34846, Turkey.
authors.forename: Tuba
authors.initials: T
authors.lastname: Unkun
mesh_terms: D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*; D017725:Ventricular Pressure / Q000502:physiology*
keywords: Diastolic dysfunction; Left ventricular end-diastolic pressure; Left ventricular longitudinal strain; Speckle tracking echocardiography