title: Orchestration of membrane receptor signaling by membrane lipids.
abstract: Receptors on cell membrane bind to their respective ligands and transduce intracellular signals resulting in variety of effector functions. Membrane lipid composition determines the receptor signaling behavior, as the receptors assume different conformation to suit the biochemical milieu in its immediate vicinity in the membrane. Accordingly, these accommodate different signaling intermediates that dictate the course of intracellular signaling and the resulting effectors functions. In this review we provide an overview of how membrane lipids modulate membrane-properties, membrane-receptor functions and their significance in the host-pathogen interaction.
authors.affiliation: Infection and Immunity Lab, Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi, 110025, India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Arish
authors.affiliation: Infection and Immunity Lab, Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi, 110025, India.
authors.forename: Atahar
authors.initials: A
authors.lastname: Husein
authors.affiliation: Infection and Immunity Lab, Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi, 110025, India.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kashif
authors.affiliation: School of Life Sciences, Central University of Himachal Pradesh, Post Box - 21, Dharamshala, Distt. - Kangra, H.P., 176215, India.
authors.forename: Padmani
authors.initials: P
authors.lastname: Sandhu
authors.affiliation: Kusuma School of Biological Sciences, Indian Institute of Technology (IIT), Hauz Khas, New Delhi, 110 016, India.
authors.forename: Seyed E
authors.initials: SE
authors.lastname: Hasnain
authors.affiliation: School of Life Sciences, Central University of Himachal Pradesh, Post Box - 21, Dharamshala, Distt. - Kangra, H.P., 176215, India.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Akhter
authors.affiliation: Infection and Immunity Lab, Department of Biotechnology, Jamia Millia Islamia (A Central University), New Delhi, 110025, India. Electronic address: abdurrub81@gmail.com.
authors.forename: Abdur
authors.initials: A
authors.lastname: Rub
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D008563:Membrane Lipids; D011956:Receptors, Cell Surface
keywords: Host–pathogen; Lipid; Membrane; Membrane properties; Receptor; Signaling