title: Inflammatory pseudotumor around metal-on-polyethylene total hip arthroplasty in patients with ankylosing spondylitis: description of two cases and review of literature.
abstract: Inflammatory pseudotumor has been commonly reported in patients undertaking total hip replacement (THR) for different reasons. The precise etiology of this biological reaction and whether the primary disease has an influence on pseudotumor formation remain unclear. There seems to be a consensus that metal ions and debris do play an important role during this process. Recently, however, compared to metal particles along, immune response induced by metal particles attracts more attention. We present two cases of pseudotumor who have accepted THR for ankylosing spondylitis (AS) and later required revision surgery and hindquarter amputation, respectively. By thorough literature review, we tried to investigate the association between inflammatory pseudotumors and immunology.
authors.affiliation: Department of Orthopaedics, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China. shenanfangfudong@126.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Fu
authors.affiliation: Department of Orthopaedics, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China. li_guo_dong2004@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Orthopaedics, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China. Shenjiakang86@126.com.
authors.forename: Jiakang
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Orthopaedics, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China. fufufudongdongdong@126.com.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Orthopaedics, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China. tutumi89@126.com.
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Cai
authors.affiliation: Department of Orthopaedics, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China. tutumi89@126.com.
authors.forename: Yingqi
authors.initials: Y
authors.lastname: Hua
mesh_terms: D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D006104:Granuloma, Plasma Cell / Q000209:etiology*; D006801:Humans; D008297:Male; D008670:Metals / Q000009:adverse effects*; D008875:Middle Aged; D020959:Polyethylene / Q000009:adverse effects*; D011379:Prognosis; D013167:Spondylitis, Ankylosing / Q000601:surgery*
chemical_list: D008670:Metals; D020959:Polyethylene