title: Neointimal coverage and late apposition of everolimus-eluting bioresorbable scaffolds implanted in the acute phase of myocardial infarction: OCT data from the PRAGUE-19 study.
abstract: Incomplete stent apposition and uncovered struts are associated with a higher risk of stent thrombosis. No data exist on the process of neointimal coverage and late apposition status of the bioresorbable vascular scaffold (BVS) when implanted in the highly thrombogenic setting of ST-segment elevation acute myocardial infarction (STEMI). The aim of this study was to assess the serial changes in strut apposition and early neointimal coverage of the BVS using optical coherence tomography (OCT) in selected patients enrolled in the PRAGUE-19 study. Intracoronary OCT was performed in 50 patients at the end of primary percutaneous coronary intervention for acute STEMI. Repeated OCT of the implanted BVS was performed in 10 patients. Scaffold area, scaffold mean diameter and incomplete strut apposition (ISA) were compared between baseline and control OCT. Furthermore, strut neointimal coverage was assessed during the control OCT. Mean scaffold area and diameter did not change between the baseline and control OCT (8.59 vs. 9.06 mm(2); p = 0.129 and 3.31 vs. 3.37 mm; p = 0.202, respectively). Differences were observed in ISA between the baseline and control OCT (0.63 vs. 1.47 %; p < 0.05). We observed 83.1 % covered struts in eight patients in whom the control OCT was performed 4-6 weeks after BVS implantation, and 100 % covered struts in two patients 6 months after BVS implantation. Persistent strut apposition and early neointimal coverage were observed after biodegradable vascular scaffold implantation in patients with acute ST-segment elevation myocardial infarction.
authors.affiliation: Third Faculty of Medicine, Cardiocenter, Charles University in Prague, University Hospital Kralovske Vinohrady, Ruska 87, 100 00, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Toušek
authors.affiliation: Third Faculty of Medicine, Cardiocenter, Charles University in Prague, University Hospital Kralovske Vinohrady, Ruska 87, 100 00, Prague, Czech Republic. viktor.kocka@fnkv.cz.
authors.forename: Viktor
authors.initials: V
authors.lastname: Kočka
authors.affiliation: First Faculty of Medicine, Cardiovascular Center, Charles University in Prague, Central Military Hospital Prague, Prague, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Malý
authors.affiliation: Third Faculty of Medicine, Cardiocenter, Charles University in Prague, University Hospital Kralovske Vinohrady, Ruska 87, 100 00, Prague, Czech Republic.
authors.forename: Libor
authors.initials: L
authors.lastname: Lisa
authors.affiliation: Third Faculty of Medicine, Cardiocenter, Charles University in Prague, University Hospital Kralovske Vinohrady, Ruska 87, 100 00, Prague, Czech Republic.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Buděšínský
authors.affiliation: Third Faculty of Medicine, Cardiocenter, Charles University in Prague, University Hospital Kralovske Vinohrady, Ruska 87, 100 00, Prague, Czech Republic.
authors.forename: Petr
authors.initials: P
authors.lastname: Widimský
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D002317:Cardiovascular Agents / Q000008:administration & dosage* / Q000009:adverse effects; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects*; D018153:Czech Republic; D000068338:Everolimus / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D058426:Neointima; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects / Q000295:instrumentation*; D011446:Prospective Studies; D011474:Prosthesis Design; D000072657:ST Elevation Myocardial Infarction / Q000000981:diagnostic imaging / Q000628:therapy*; D013997:Time Factors; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome
chemical_list: D002317:Cardiovascular Agents; D020099:Coated Materials, Biocompatible; D000068338:Everolimus
keywords: Acute myocardial infarction; Biodegradable vascular scaffold; Late apposition; Neointimal coverage