title: Soy β-conglycinin improves obesity-induced metabolic abnormalities in a rat model of nonalcoholic fatty liver disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) has a variety of causes including calorie over-intake, an unbalanced diet, and/or genetic dysfunction of lipid metabolism. We hypothesized that NAFLD symptoms could be mitigated by specific nutritional factors. Here, we show that the potential for soy β-conglycinin (βCG) to improve obesity-induced metabolic abnormalities in the Otsuka Long Evans Tokushima fatty (OLETF) rat model of NAFLD. Long Evans Tokushima Otsuka (i.e., wild-type) and OLETF rats were provided a normal diet containing 20% casein for 4 weeks as a control. In a third (βCG) group, OLETF rats were fed a diet in which half of the casein was replaced by βCG. There was no difference in food intake between groups. Rats in the βCG group had decreased liver weight and lipid content (triglycerides, cholesterol, and phospholipids) compared to controls. In addition, βCG consumption decreased fatty acid synthase gene expression and enzymatic activity. These findings indicate that dietary intake of βCG can improve obesity-induced metabolic dysfunction, possibly via suppression of de novo fatty acid synthesis.
authors.affiliation: Basic Research Institute, R&D, Fuji Oil Co., Ltd., 4-3 Kinunodai, Tsukubamirai-shi, Ibaraki 300-2497, Japan. Electronic address: wanezaki.satoshi@so.fujioil.co.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Wanezaki
authors.affiliation: Basic Research Institute, R&D, Fuji Oil Co., Ltd., 1 Sumiyoshi-cho, Izumisano, Osaka 598-8540, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Tachibana
authors.affiliation: Basic Research Institute, R&D, Fuji Oil Co., Ltd., 1 Sumiyoshi-cho, Izumisano, Osaka 598-8540, Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Nagata
authors.affiliation: Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Saito
authors.affiliation: Department of Applied Biochemistry and Food Science, Saga University, Saga 840-8502, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Nagao
authors.affiliation: Department of Health and Nutrition Sciences, Faculty of Health and Social Welfare Sciences, Nishikyushu University, 4490-9 Ozaki, Kanzaki, Saga 842-8585, Japan.
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Yanagita
authors.affiliation: Basic Research Institute, R&D, Fuji Oil Co., Ltd., 4-3 Kinunodai, Tsukubamirai-shi, Ibaraki 300-2497, Japan.
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Kohno
mesh_terms: D000818:Animals; D052179:Antigens, Plant / Q000494:pharmacology / Q000627:therapeutic use*; D004044:Dietary Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D015870:Gene Expression / Q000187:drug effects; D005916:Globulins / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D050155:Lipogenesis / Q000187:drug effects* / Q000235:genetics; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000178:diet therapy* / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D020334:Rats, Inbred OLETF; D055314:Seed Storage Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D030262:Soybean Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D013025:Glycine max / Q000737:chemistry*
chemical_list: D052179:Antigens, Plant; D004044:Dietary Proteins; D005916:Globulins; D008055:Lipids; D010936:Plant Extracts; D055314:Seed Storage Proteins; D030262:Soybean Proteins; C013894:beta-conglycinin protein, Glycine max
keywords: Fatty acid synthase; NAFLD; OLETF; βCG