title: The characteristics and health needs of pregnant women with schizophrenia compared with bipolar disorder and affective psychoses.
abstract: BACKGROUND
  Most women with psychotic disorders and bipolar disorders have children but their pregnancies are at risk of adverse psychiatric and fetal outcome. The extent of modifiable risk factors - both clinical and socio-demographic - is unclear as most studies have used administrative data or recruited from specialist tertiary referral clinics. We therefore aimed to investigate the socio-demographic and clinical characteristics of an epidemiologically representative cohort of pregnant women with affective and non-affective severe mental illness.
  
  
  METHODS
  Women with severe mental illness were identified from a large electronic mental health case register in south London, and a data linkage with national maternity Hospital Episode Statistics identified pregnancies in 2007-2011. Data were extracted using structured fields, text searching and natural language processing applications.
  
  
  RESULTS
  Of 456 pregnant women identified, 236 (51.7%) had schizophrenia and related disorders, 220 (48.3%) had affective psychosis or bipolar disorder. Women with schizophrenia and related disorders were younger, less likely to have a partner in pregnancy, more likely to be black, to smoke or misuse substances and had significantly more time in the two years before pregnancy in acute care (inpatient or intensive home treatment) compared with women with affective disorders. Both groups had high levels of domestic abuse in pregnancy (recorded in 18.9%), were from relatively deprived backgrounds and had impaired functioning measured by the Health of the Nation Outcome Scale. Women in the affective group were more likely to stop medication in the first trimester (39% versus 25%) whereas women with non-affective psychoses were more likely to switch medication.
  
  
  CONCLUSIONS
  A significant proportion of women, particularly those with non-affective psychoses, have modifiable risk factors requiring tailored care to optimize pregnancy outcomes. Mental health professionals need to be mindful of the possibility of pregnancy in women of childbearing age and prescribe and address modifiable risk factors accordingly.
authors.affiliation: Section of Women's Mental Health/Women's Health Academic Centre, Department of Health Service and Population Research, King's College London, Institute of Psychiatry, London, UK. clare.l.taylor@kcl.ac.uk.
authors.forename: Clare L
authors.initials: CL
authors.lastname: Taylor
authors.affiliation: Department of Psychological Medicine, King's College London, Institute of Psychiatry, London, UK. Robert.stewart@kcl.ac.uk.
authors.forename: Robert
authors.initials: R
authors.lastname: Stewart
authors.affiliation: Section of Women's Mental Health/Women's Health Academic Centre, Department of Health Service and Population Research, King's College London, Institute of Psychiatry, London, UK. jack.odgen@kcl.ac.uk.
authors.forename: Jack
authors.initials: J
authors.lastname: Ogden
authors.affiliation: South London and Maudsley NHS Foundation Trust, London, UK. matthew.broadbent@slam.nhs.uk.
authors.forename: Matthew
authors.initials: M
authors.lastname: Broadbent
authors.affiliation: Women's Health Academic Centre, King's College London, London, UK. dharmintra.pasupathy@kcl.ac.uk.
authors.forename: Dharmintra
authors.initials: D
authors.lastname: Pasupathy
authors.affiliation: Section of Women's Mental Health/Women's Health Academic Centre, Department of Health Service and Population Research, King's College London, Institute of Psychiatry, London, UK. louise.howard@kcl.ac.uk.
authors.forename: Louise M
authors.initials: LM
authors.lastname: Howard
mesh_terms: D000328:Adult; D000341:Affective Disorders, Psychotic / Q000453:epidemiology*; D001714:Bipolar Disorder / Q000453:epidemiology*; D005260:Female; D006301:Health Services Needs and Demand / Q000706:statistics & numerical data*; D006801:Humans; D008131:London / Q000453:epidemiology; D011247:Pregnancy; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology*; D013179:Spouse Abuse / Q000706:statistics & numerical data