title: AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?
abstract: Intracellular pathogens are known to manipulate host cell regulatory pathways to establish an optimal environment for their growth and survival. Pathogens employ active mechanisms to hijack host cell metabolism and acquire existing nutrient and energy store. The role of the cellular energy sensor AMP-activated protein kinase (AMPK) in the regulation of cellular energy homeostasis is well documented. Here, we highlight recent advances showing the importance of AMPK signaling in pathogen-host interactions. Pathogens interact with AMPK by a variety of mechanisms aimed at reprogramming host cell metabolism to their own benefit. Stimulation of AMPK activity provides an efficient process to rapidly adapt pathogen metabolism to the major nutritional changes often encountered during the different phases of infection. However, inhibition of AMPK is also used by pathogens to manipulate innate host response, indicating that AMPK appears relevant to restriction of pathogen infection. We also document the effects of pharmacological AMPK modulators on pathogen proliferation and survival. This review illustrates intricate pathogen-AMPK interactions that may be exploited to the development of novel anti-pathogen therapies.
authors.forename: Diana
authors.initials: D
authors.lastname: Moreira
authors.forename: Ricardo
authors.initials: R
authors.lastname: Silvestre
authors.forename: Anabela
authors.initials: A
authors.lastname: Cordeiro-da-Silva
authors.forename: Jérôme
authors.initials: J
authors.lastname: Estaquier
authors.forename: Marc
authors.initials: M
authors.lastname: Foretz
authors.affiliation: Institut Cochin, Inserm U1016, CNRS UMR8104, Université Paris Descartes, 24 rue du faubourg Saint Jacques 75014 Paris, France. benoit.viollet@inserm.fr.
authors.forename: Benoit
authors.initials: B
authors.lastname: Viollet
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D018407:Bacterial Physiological Phenomena / Q000187:drug effects; D003141:Communicable Diseases / Q000201:enzymology* / Q000382:microbiology / Q000469:parasitology; D004734:Energy Metabolism; D004789:Enzyme Activation; D006706:Homeostasis; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D010271:Parasites / Q000187:drug effects / Q000502:physiology*; D010766:Phosphorylation; D060066:Protein Interaction Maps; D015398:Signal Transduction; D018406:Virus Physiological Phenomena / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D055372:AMP-Activated Protein Kinases