title: Assessing breast tumor margin by multispectral photoacoustic tomography.
abstract: An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin assessment using fat and hemoglobin as contrasts. This system provides ~3 mm tissue depth and ~125 μm axial resolution. The results agreed with the histological findings. A high sensitivity in margin assessment was accomplished, which opens a compelling way to intraoperative margin assessment.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Drive., West Lafayette, Indiana, 47907, USA ; Authors contributed equally.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Drive., West Lafayette, Indiana, 47907, USA ; Authors contributed equally.
authors.forename: Pu
authors.initials: P
authors.lastname: Wang
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Drive., West Lafayette, Indiana, 47907, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Lan
authors.affiliation: Surgical Oncology- Cascade Metrix/Putman County Hospital, 1542 S Bloomington Street, Greencastle, Indiana, 46135, USA.
authors.forename: Frank P
authors.initials: FP
authors.lastname: Lloyd
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Drive., West Lafayette, Indiana, 47907, USA ; Purdue University Center for Cancer Research, 201 S. University Street, West Lafayette, Indiana, 47906, USA.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Goergen
authors.affiliation: Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, Indiana, 46202, USA.
authors.forename: Shaoxiong
authors.initials: S
authors.lastname: Chen
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Drive., West Lafayette, Indiana, 47907, USA ; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana, 47907, USA ; Purdue University Center for Cancer Research, 201 S. University Street, West Lafayette, Indiana, 47906, USA.
authors.forename: Ji-Xin
authors.initials: JX
authors.lastname: Cheng
keywords: (000.2700) General science; (110.5120) Photoacoustic imaging