title: [Pancreatic cancer- a curable disease].
abstract: Pancreatic cancer is the seventh most common cancer in Switzerland associated with a dismal prognosis. Its natural course is fatal with a 3-year survival rate below 3%. Advances in diagnostic tools, tumor staging and multimodal treatment strategies resulted in an improved 5-year survival rate of over 20%. Patients presenting with pancreatic cancer significantly benefit from a multi-disciplinary treatment strategy in an experienced hepato-pancreato-biliary center. Following a comprehensive tumor staging, surgical resection associated with adjuvant chemotherapy is still the only curative therapy option. The role of neoadjuvant chemotherapy is currently investigated in clinical trials. Patients presenting with advanced pancreatic cancer not eligible for curative treatment might benefit from inclusion into innovative clinical trials with novel treatment concepts.
authors.affiliation: Schweizerisches Hepato-Pancreato-Biliäres Zentrum und Departement Chirurgie, Universitätsspital Zürich.
authors.forename: Perparim
authors.initials: P
authors.lastname: Limani
authors.affiliation: Schweizerisches Hepato-Pancreato-Biliäres Zentrum und Klinik für Onkologie, Universitätsspital Zürich.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Samaras
authors.affiliation: Schweizerisches Hepato-Pancreato-Biliäres Zentrum und Departement Chirurgie, Universitätsspital Zürich.
authors.forename: Mickael
authors.initials: M
authors.lastname: Lesurtel
authors.affiliation: Schweizerisches Hepato-Pancreato-Biliäres Zentrum und Departement Chirurgie, Universitätsspital Zürich.
authors.forename: Rolf
authors.initials: R
authors.lastname: Graf
authors.affiliation: Schweizerisches Hepato-Pancreato-Biliäres Zentrum und Departement Chirurgie, Universitätsspital Zürich.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: DeOliveira
authors.affiliation: Schweizerisches Hepato-Pancreato-Biliäres Zentrum und Departement Chirurgie, Universitätsspital Zürich.
authors.forename: Henrik
authors.initials: H
authors.lastname: Petrowsky
authors.affiliation: Schweizerisches Hepato-Pancreato-Biliäres Zentrum und Departement Chirurgie, Universitätsspital Zürich.
authors.forename: Pierre-Alain
authors.initials: PA
authors.lastname: Clavien
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D003299:Cooperative Behavior; D018572:Disease-Free Survival; D006801:Humans; D033183:Interdisciplinary Communication; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate
keywords: Pankreas-Chirurgie; Pankreaskarzinom; Pankreatoduodenektomie; Whipple Operation; cancer du pancréas; chirurgie pancréatique; duodenopancréatectomie; multimodal treatment; multimodale Therapie; neoadjuvant and adjuvant chemotherapies; neoadjuvante und adjuvante Chemotherapie; néoadjuvante et adjuvante chimiothérapies; pancreatic cancer; pancreatic resection; pancreaticoduodenectomy; traitement multimodal