title: Synthesis of a new class of furo[3,2-c]coumarins and its anticancer activity.
abstract: A series of furo[3,2-c]coumarin derivatives 1a-d were synthesized and evaluated for their antiproliferative activity against MCF-7 breast and HCT-15 colon cancer cell lines using Sulfo-rhodamine B (SRB) assay. Compounds 1b and 1d showed higher antiproliferative activity than 1a and 1c. UV-Vis spectroscopy was used for DNA and BSA-binding affinity of the compounds 1b and 1d and gave overall affinity constants of K1b-DNA=8.1×10(3) M(-1), K1d-DNA=1.1×10(4) M(-1), K1b-BSA=5.1×10(4) M(-1), and K1d-BSA=7.6×10(4) M(-1). Our findings could provide new evidence showing the relationship between the chemical structure and anticancer activity of these new coumarin analogs.
authors.affiliation: The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Rajabi
authors.affiliation: Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
authors.forename: Zinatossadat
authors.initials: Z
authors.lastname: Hossaini
authors.affiliation: Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Khalilzadeh
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
authors.forename: Shubhashis
authors.initials: S
authors.lastname: Datta
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
authors.forename: Mintu
authors.initials: M
authors.lastname: Halder
authors.affiliation: The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA. Electronic address: shaker.mousa@acphs.edu.
authors.forename: Shaker A
authors.initials: SA
authors.lastname: Mousa
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D001665:Binding Sites; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D061986:MCF-7 Cells; D062105:Molecular Docking Simulation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D012710:Serum Albumin, Bovine; D004247:DNA; C030123:coumarin