title: Hippocampal subfield surface deformity in non-semantic primary progressive aphasia.
abstract: BACKGROUND
  Alzheimer neuropathology (AD) is found in almost half of patients with non-semantic primary progressive aphasia (PPA). This study examined hippocampal abnormalities in PPA to determine similarities to those described in amnestic AD.
  
  
  METHODS
  In 37 PPA patients and 32 healthy controls, we generated hippocampal subfield surface maps from structural MRIs and administered a face memory test. We analyzed group and hemisphere differences for surface shape measures and their relationship with test scores and ApoE genotype.
  
  
  RESULTS
  The hippocampus in PPA showed inward deformity (CA1 and subiculum subfields) and outward deformity (CA2-4+DG subfield) and smaller left than right volumes. Memory performance was related to hippocampal shape abnormalities in PPA patients, but not controls, even in the absence of memory impairments.
  
  
  CONCLUSIONS
  Hippocampal deformity in PPA is related to memory test scores. This may reflect a combination of intrinsic degenerative phenomena with transsynaptic or Wallerian effects of neocortical neuronal loss.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Division of Clinical Psychology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: Adam
authors.initials: A
authors.lastname: Christensen
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Division of Clinical Psychology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Alpert
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: Emily
authors.initials: E
authors.lastname: Rogalski
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Division of Clinical Psychology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: Derin
authors.initials: D
authors.lastname: Cobia
authors.affiliation: Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: Julia
authors.initials: J
authors.lastname: Rao
authors.affiliation: Biomedical Engineering, Simon Fraser University, BC, Canada.
authors.forename: Mirza Faisal
authors.initials: MF
authors.lastname: Beg
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Division of Clinical Psychology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 ; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 ; Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: Sandra
authors.initials: S
authors.lastname: Weintraub
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Division of Clinical Psychology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 ; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 ; Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: M-Marsel
authors.initials: MM
authors.lastname: Mesulam
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Division of Clinical Psychology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 ; Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
keywords: Alzheimer’s disease (AD); frontotemporal dementia; lobar degeneration; memory; multi-atlas mapping; neuroanatomy; primary progressive aphasia (PPA); structural magnetic resonance imaging (MRI)