title: Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation.
abstract: The interleukin-17 (IL-17) family of cytokines has emerged as a critical player in inflammatory diseases. Among them, IL-25 has been shown to be important in allergic inflammation and protection against parasitic infection. Here we have demonstrated that IL-17B, a poorly understood cytokine, functions to inhibit IL-25-driven inflammation. IL-17B and IL-25, both binding to the interleukin-17 receptor B (IL-17RB), were upregulated in their expression after acute colonic inflammation. Individual inhibition of these cytokines revealed opposing functions in colon inflammation: IL-25 was pathogenic but IL-17B was protective. Similarly opposing phenotypes were observed in Citrobacter rodentium infection and allergic asthma. Moreover, IL-25 was found to promote IL-6 production from colon epithelial cells, which was inhibited by IL-17B. Therefore, our data demonstrate that IL-17B is an anti-inflammatory cytokine in the IL-17 family.
authors.affiliation: Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Reynolds
authors.affiliation: Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Institute for Immunology, Tsinghua University, Beijing 100084, China.
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumthani 12120, Thailand.
authors.forename: Pornpimon
authors.initials: P
authors.lastname: Angkasekwinai
authors.affiliation: Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Kalyan C
authors.initials: KC
authors.lastname: Nallaparaju
authors.affiliation: Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Flaherty
authors.affiliation: Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054, USA.
authors.forename: Seon Hee
authors.initials: SH
authors.lastname: Chang
authors.affiliation: Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), 7, Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watarai
authors.affiliation: Institute for Immunology, Tsinghua University, Beijing 100084, China. Electronic address: chendong@tsinghua.edu.cn.
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D001249:Asthma / Q000139:chemically induced / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D002460:Cell Line; D044082:Citrobacter rodentium / Q000276:immunology; D003092:Colitis / Q000139:chemically induced / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D064806:Dysbiosis / Q000139:chemically induced / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D004756:Enterobacteriaceae Infections / Q000235:genetics / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D004847:Epithelial Cells / Q000276:immunology / Q000473:pathology; D005786:Gene Expression Regulation; D020381:Interleukin-17 / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology; D007378:Interleukins / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010047:Ovalbumin; D011485:Protein Binding; D053722:Receptors, Interleukin-17 / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D012967:Sodium Dodecyl Sulfate
chemical_list: D000900:Anti-Bacterial Agents; C515929:Il17b protein, mouse; D020381:Interleukin-17; D015850:Interleukin-6; D007378:Interleukins; C442281:Mydgf protein, mouse; D053722:Receptors, Interleukin-17; D012967:Sodium Dodecyl Sulfate; D010047:Ovalbumin