title: Serum cystatin C and microalbuminuria in burn patients with acute kidney injury.
abstract: BACKGROUND
  This study was aimed at evaluating the effectiveness of serum cystatin C and microalbuminuria as diagnostic markers for acute kidney injury (AKI) in major burn patients.
  
  
  METHODS
  Major burn adult patients admitted to the burn intensive care unit within 24 h from the onset of injury were enrolled. Serum cystatin C and microalbuminuria (albumin-creatinine ratio, ACR) were obtained at postburn days 1, 3, 7, 14, 21 and 28. The patients were divided into two groups of the AKI group and the nonacute kidney injury group.
  
  
  RESULTS
  A total of 97 patients were enrolled in this study. Acute kidney injury was diagnosed in 40 patients (41.2%) at postburn day 17.3 ± 7.9. The area under the curve of the receiver operating characteristic curve for serum cystatin C was 0.808 (95% CI, 0.711-0.905, P < 0.001) at postburn day 7 and 0.908 (95% CI, 0.843-0.973, P < 0.001) at postburn day 14. The results were 0.610 (95% CI, 0.497-0.724, P = 0.069) for ACR at postburn day 7 and 0.694 (95% CI, 0.589-0.798, P = 0.001) at postburn day 14. The optimal cut-off value of serum cystatin C at postburn day 14 and ACR at postburn day 14 were 0.85 mg/L (sensitivity, 89.5%; specificity, 82.5%) and 41.51 mg/g cre (sensitivity, 60.5%; specificity, 61.4%), respectively. Serum cystatin C at postburn day 14 was the only significant factor in relation to AKI.
  
  
  CONCLUSIONS
  Serum cystatin C is a valuable diagnostic marker, whereas microalbuminuria is a relatively less significant marker for AKI in major burn patients.
authors.affiliation: Department of Burn Surgery and Critical Care, Burn Center, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Haejun
authors.initials: H
authors.lastname: Yim
authors.affiliation: Department of Burn Surgery and Critical Care, Burn Center, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Dohern
authors.initials: D
authors.lastname: Kym
authors.affiliation: Department of Plastic & Reconstructive Surgery, Burn Center, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Dong Kook
authors.initials: DK
authors.lastname: Seo
authors.affiliation: Department of Burn Surgery and Critical Care, Burn Center, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Jaechul
authors.initials: J
authors.lastname: Yoon
authors.affiliation: Department of Burn Surgery and Critical Care, Burn Center, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Hyeong-Tae
authors.initials: HT
authors.lastname: Yang
authors.affiliation: Department of Nephrology, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Jeonghwan
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Burn Surgery and Critical Care, Burn Center, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Yong-Suk
authors.initials: YS
authors.lastname: Cho
authors.affiliation: Department of Burn Surgery and Critical Care, Burn Center, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Jun
authors.initials: J
authors.lastname: Hur
authors.affiliation: Department of Burn Surgery and Critical Care, Burn Center, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Wook
authors.initials: W
authors.lastname: Chun
authors.affiliation: Department of Cardiology, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Han
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology; D000419:Albuminuria / Q000097:blood / Q000209:etiology*; D015415:Biomarkers / Q000378:metabolism; D002056:Burns / Q000097:blood / Q000150:complications / Q000652:urine; D003404:Creatinine / Q000378:metabolism; D055316:Cystatin C / Q000378:metabolism*; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D003404:Creatinine
keywords: Acute kidney injury; cystatin C; major burn; microalbuminuria