title: The role of death-associated protein 3 in apoptosis, anoikis and human cancer.
abstract: Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in response to irreparable damage to DNA, or in response to induction by inflammatory cells. Anoikis is subset of apoptosis which occurs in epithelial cells in response to detachment from the surrounding matrix. Both apoptosis and anoikis are of interest in the context of carcinogenesis. In this review, we shall discuss apoptosis and anoikis, and the recent literature regarding the role of DAP3 in both these pathways.
authors.affiliation: The London Breast Institute, Princess Grace Hospital, London, UK ; Department of Breast Surgery, St. George's Hospital and Medical School, University of London, London, UK.
authors.forename: Umar
authors.initials: U
authors.lastname: Wazir
authors.affiliation: Ayub Medical College, Abbottabad, Pakistan.
authors.forename: Mona Maw
authors.initials: MM
authors.lastname: Orakzai
authors.affiliation: Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff University School of Medicine, Cardiff University, Cardiff, Wales UK.
authors.forename: Zubair S
authors.initials: ZS
authors.lastname: Khanzada
authors.affiliation: Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff University School of Medicine, Cardiff University, Cardiff, Wales UK.
authors.forename: Wen G
authors.initials: WG
authors.lastname: Jiang
authors.affiliation: Department of Breast Surgery, St. George's Hospital and Medical School, University of London, London, UK.
authors.forename: Anup K
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: The London Breast Institute, Princess Grace Hospital, London, UK.
authors.forename: Abdul
authors.initials: A
authors.lastname: Kasem
authors.affiliation: The London Breast Institute, Princess Grace Hospital, London, UK ; Department of Breast Surgery, St. George's Hospital and Medical School, University of London, London, UK.
authors.forename: Kefah
authors.initials: K
authors.lastname: Mokbel
keywords: Anoikis; Apoptosis; Breast cancer; Cancer; Carcinogenesis; Death-associated protein 3; Oncogenesis; Review