title: Neuronal Circuits for Fear Expression and Recovery: Recent Advances and Potential Therapeutic Strategies.
abstract: Recent technological developments, such as single unit recordings coupled to optogenetic approaches, have provided unprecedented knowledge about the precise neuronal circuits contributing to the expression and recovery of conditioned fear behavior. These data have provided an understanding of the contributions of distinct brain regions such as the amygdala, prefrontal cortex, hippocampus, and periaqueductal gray matter to the control of conditioned fear behavior. Notably, the precise manipulation and identification of specific cell types by optogenetic techniques have provided novel avenues to establish causal links between changes in neuronal activity that develop in dedicated neuronal structures and the short and long-lasting expression of conditioned fear memories. In this review, we provide an update on the key neuronal circuits and cell types mediating conditioned fear expression and recovery and how these new discoveries might refine therapeutic approaches for psychiatric conditions such as anxiety disorders and posttraumatic stress disorder.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U862, Neurocenter Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Dejean
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U862, Neurocenter Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Courtin
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U862, Neurocenter Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Rozeske
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U862, Neurocenter Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.; Universitaire de Bordeaux, Institut de Bio-imagerie de Bordeaux, Bordeaux, France.
authors.forename: Mélissa C
authors.initials: MC
authors.lastname: Bonnet
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U862, Neurocenter Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.; Universitaire de Bordeaux, Institut de Bio-imagerie de Bordeaux, Bordeaux, France.; Centre Hospitalier Universitaire de Bordeaux, Service de NeuroImagerie Diagnostique et Thérapeutique, Bordeaux, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Dousset
authors.affiliation: Unite Mixte de Recherche Centre National de la Recherche Scientifique 5293, Institut des maladies Neurodégénératives, Bordeaux, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Michelet
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U862, Neurocenter Magendie, Physiopathologie de la Plasticité Neuronale, Bordeaux, France.. Electronic address: cyril.herry@inserm.fr.
authors.forename: Cyril
authors.initials: C
authors.lastname: Herry
mesh_terms: D000818:Animals; D001007:Anxiety / Q000473:pathology / Q000628:therapy; D001921:Brain / Q000473:pathology* / Q000502:physiology*; D005239:Fear; D006801:Humans; D009434:Neural Pathways / Q000502:physiology*; D062308:Optogenetics; D020127:Recovery of Function / Q000502:physiology*
keywords: Amygdala; Anxiety disorders; Fear expression; Neuronal circuits; Prefrontal cortex; Single unit recordings