title: A randomized, crossover trial to evaluate the effect of two mouthrinses on plaque regrowth in the absence of brushing.
abstract: This study assessed the effects on plaque in the absence of brushing of two twice-daily mouthrinses, one with an enzymatic-based formulation (Biotène) and one with an antimicrobial chlorhexidine-based formulation (Peridex), and sterile water. Plaque levels were assessed in 23 participants using a 4-day, nonbrushing plaque regrowth model after twice-daily rinsing with sterile water (negative control), the enzyme-based mouthrinse, or the chlorhexidine-based mouthrinse (positive control). Peridex showed significantly greater prevention of plaque regrowth when compared with water and the enzyme-based Biotène mouthrinse. After 4 days, the enzyme-based mouthrinse was associated with a small but nonsignificant reduction in plaque regrowth compared with water. This study confirmed that Peridex is effective at prevention of plaque regrowth. Twice-daily rinsing with a Biotène formula that contained enzymes showed a small but nonsignificant trend toward prevention of plaque regrowth versus rinsing with water.
authors.forename: Marc
authors.initials: M
authors.lastname: Nehme
authors.forename: Katy
authors.initials: K
authors.lastname: Malpass
authors.forename: Andrew
authors.initials: A
authors.lastname: Butler
authors.forename: Stephen
authors.initials: S
authors.lastname: Mason
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Kleber
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Milleman
authors.forename: Kimberly R
authors.initials: KR
authors.lastname: Milleman
mesh_terms: D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004338:Drug Combinations; D005260:Female; D005949:Glucose Oxidase / Q000627:therapeutic use*; D006801:Humans; D007784:Lactoperoxidase / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000627:therapeutic use*; D014099:Toothbrushing
chemical_list: D000891:Anti-Infective Agents, Local; C111669:Biotene; D004338:Drug Combinations; D005949:Glucose Oxidase; D007784:Lactoperoxidase; D009113:Muramidase; C010882:chlorhexidine gluconate; D002710:Chlorhexidine