title: Analysis of age, refractive error and gender related changes of the cornea and the anterior segment of the eye with Scheimpflug imaging.
abstract: OBJECTIVE
  To assess age, refractive error and gender related changes occurring in the cornea and the anterior segment of the eye using a Scheimpflug system.
  
  
  METHODS
  The study included 666 healthy eyed subjects with a mean age of 39.3±19.7 years (range: 3-85 years). All analyses were based on the right eyes of the patients as all measured parameters correlated well between the right and left eyes. Each parameter was correlated with age and the right eye's spherical equivalent (SE) using Pearson correlations. Univariate linear regression models were constructed for analyses of parameters.
  
  
  RESULTS
  The anterior corneal surface asphericity showed significant positive correlations whereas posterior corneal surface asphericity showed significant negative correlations with age. Anterior chamber depth (ACD), volume (ACV) and angle (ACA) showed significant negative correlations with age and SE. Age explained 25% of the variance in anterior corneal surface asphericity, 22% of variance in posterior corneal surface asphericity, 26% of variance in ACV, 27% of variance in ACD, and 19% of variance in ACA. In the SE model SE was identified to account for 25% of variance in ACV, 22% of variance in ACD, each, and 17% of variance in ACA. Significant differences were detected in anterior and posterior keratometry values, ACV, ACD and ACA among gender groups (p<0.01).
  
  
  CONCLUSIONS
  The cornea shows a tendency for a decrease in anterior corneal surface asphericity and an increase in posterior corneal surface asphericity with advancing age. Men have flatter corneas and women have shallower anterior chambers and narrower anterior chamber angles.
authors.affiliation: Birinci Eye Hospital, Istanbul, Turkey. Electronic address: faikorucov@yahoo.co.uk.
authors.forename: Faik
authors.initials: F
authors.lastname: Orucoglu
authors.affiliation: Marmara University, School of Medicine, Department of Family Medicine, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akman
authors.affiliation: Koc University, School of Medicine, Department of Ophthalmology, Istanbul, Turkey; V.K. Foundation, American Hospital, Department of Ophthalmology, Istanbul, Turkey.
authors.forename: Sumru
authors.initials: S
authors.lastname: Onal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000869:Anterior Eye Segment / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000503:physiopathology*; D063171:Corneal Pachymetry / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012029:Refraction, Ocular; D012030:Refractive Errors / Q000175:diagnosis / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012727:Sex Characteristics; D055815:Young Adult
keywords: Aging; Anterior chamber; Cornea; Gender; Pentacam; Refraction