title: [Synthetic lethal genes to mutant p53].
abstract: Targeted therapy has become a powerful approach for cancer treatment. Better understanding of oncogenes as well as synthetic lethal interactions with oncogenes will lead to new strategies for tumor-specific treatment. It is well known that mutant p53 plays an important role in tumorigenesis and tumor development. Thus, understanding the synthetic lethal relationship between p53 mutations and interacting genes in tumor is critical for the personalized treatments of p53 mutant tumors. Synthetic lethal genes to mutant p53 can be divided into cell cycle regulators and non-cell cycle regulators. This paper review show these two types of target genes contribute to synthetic lethal interactions with p53 mutations and potential applications of these interactions in anticancer therapy.
authors.affiliation: 1.School of Life Science and Biotechnology, Kunming University of Science and Technology, Kunming 650500, China.|2.Laboratory of Molecular Genetics of Aging and Tumor, Medical College of Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Tong-Yang
authors.initials: TY
authors.lastname: Liu
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Medical College of Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Hai-Qiang
authors.initials: HQ
authors.lastname: Guo
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Medical College of Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Mei-Yan
authors.initials: MY
authors.lastname: Zhu
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Medical College of Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Ying-Ze
authors.initials: YZ
authors.lastname: Huang
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Medical College of Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Shu-Ting
authors.initials: ST
authors.lastname: Jia
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Medical College of Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Medical College of Kunming University of Science and Technology, Kunming 650500, China.
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005804:Genes, Lethal; D005813:Genes, Synthetic; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000628:therapy; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53