title: Self-assembled nanoparticle of common food constituents that carries a sparingly soluble small molecule.
abstract: A previously reported nanoparticle formed through the self-assembly of common food constituents (amylose, protein, and fatty acids) was shown to have the capacity to carry a sparingly soluble small molecule (1-naphthol) in a dispersed system. Potentiometric titration showed that 1-naphthol locates in the lumen of the amylose helix of the nanoparticle. This finding was further supported by calorimetric measurements, showing higher enthalpies of dissociation and reassociation in the presence of 1-naphthol. Visually, the 1-naphthol-loaded nanoparticle appeared to be well-dispersed in aqueous solution. Molecular dynamics simulation showed that the self-assembly was favorable, and at 500 ns, the 1-naphthol molecule resided in the helix of the amylose lumen in proximity to the hydrophobic tail of the fatty acid. Thus, sparingly soluble small molecules, such as some nutraceuticals or drugs, could be incorporated and delivered by this soft nanoparticle carrier.
authors.affiliation: †Whistler Center for Carbohydrate Research, Purdue University, 745 Agriculture Mall Drive, West Lafayette, Indiana 47907-2009, United States.
authors.forename: Deepak
authors.initials: D
authors.lastname: Bhopatkar
authors.affiliation: †Whistler Center for Carbohydrate Research, Purdue University, 745 Agriculture Mall Drive, West Lafayette, Indiana 47907-2009, United States.|‡School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Haiquan Road, Shanghai 201418, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.affiliation: §Rosen Center for Advanced Computing, Information Technology at Purdue (ITaP), Purdue University, 155 South Grant Street, West Lafayette, Indiana 47907-2108, United States.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.affiliation: ∥School of Food Science and Technology, Jiangnan University, Wuxi, Jiansu 21422, People's Republic of China.
authors.forename: Genyi
authors.initials: G
authors.lastname: Zhang
authors.affiliation: #Qatar Environment and Energy Research Institute, P.O. Box 5825, Doha, Qatar.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Carignano
authors.affiliation: ⊥Biomedical Engineering Department and Chemistry of Life Processes Institute, Northwestern University, 2170 Campus Drive, Evanston, Illinois 60208, United States.
authors.forename: Sung Hyun
authors.initials: SH
authors.lastname: Park
authors.affiliation: †Whistler Center for Carbohydrate Research, Purdue University, 745 Agriculture Mall Drive, West Lafayette, Indiana 47907-2009, United States.
authors.forename: Haining
authors.initials: H
authors.lastname: Zhuang
authors.affiliation: †Whistler Center for Carbohydrate Research, Purdue University, 745 Agriculture Mall Drive, West Lafayette, Indiana 47907-2009, United States.
authors.forename: Osvaldo H
authors.initials: OH
authors.lastname: Campanella
authors.affiliation: †Whistler Center for Carbohydrate Research, Purdue University, 745 Agriculture Mall Drive, West Lafayette, Indiana 47907-2009, United States.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Hamaker
mesh_terms: D000688:Amylose / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D005504:Food Analysis; D057927:Hydrophobic and Hydrophilic Interactions; D056004:Molecular Dynamics Simulation; D053758:Nanoparticles / Q000737:chemistry*; D009284:Naphthols / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D005227:Fatty Acids; D009284:Naphthols; D011506:Proteins; C029350:1-naphthol; D000688:Amylose
keywords: hydrophobic; molecular dynamics simulation; molecular inclusion; small molecules; soft nanoparticles