title: Invasive Group B Streptococcal Disease in Non-pregnant Adults, Réunion Island, 2011.
abstract: OBJECTIVE
  While the prevalence of Group B streptococcus (GBS) colonization is important, little is known about invasive GBS (iGBS) disease in tropical areas. Our objective was to assess the burden of iGBS disease among non-pregnant adults.
  
  
  METHODS
  A prospective hospital-based study of all non-pregnant adult patients with iGBS disease was conducted between January and December 2011 in Saint Pierre, Réunion Island, to assess its cumulative incidence rate (CIR). Capsular serotyping and multilocus sequence typing were performed to characterize GBS isolates. Case-control study was done to identify risk factors.
  
  
  RESULTS
  The overall CIR of iGBS disease was 10.1 per 100,000. The CIR in elderly patients (≥ 65 yrs) was estimated at 40.6 per 100.000, and that of adults (15-64 years) at 6.7 per 100.000. Aboriginal origin in the Indian Ocean and overweight were both associated with iGBS disease. The most prominent clinical forms were osteo-articular and skin/soft tissue infections, as a consequence of diabetic foot. The serotypes were classic, type-Ia being the most prevalent. The hyper virulent ST-17 (CC17) was associated with type-III.
  
  
  CONCLUSIONS
  The incidence of iGBS disease found in Réunion island is twofold that usually reported. This burden is linked to overweight in aboriginal people from the Indian Ocean.
authors.affiliation: Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France. Electronic address: guillaume.camuset@chu-reunion.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Camuset
authors.affiliation: Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Picot
authors.affiliation: Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Jaubert
authors.affiliation: Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France.
authors.forename: Gianandrea
authors.initials: G
authors.lastname: Borgherini
authors.affiliation: Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Ferdynus
authors.affiliation: Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Foucher
authors.affiliation: Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France.
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Maïza
authors.affiliation: Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Fels
authors.affiliation: Centre National de Référence des Streptocoques, Groupe Hospitalier Cochin-Saint Vincent de Paul, Assistance Publique-Hôpitaux de Paris, F- 75679 Paris, France; Institut Cochin-Inserm; U567-UMR CNRS 10, Université Paris Descartes, F-75014 Paris, France; Unité Biologie des Bactéries Pathogènes à Gram-Positif-URA CNRS 2172, Institut Pasteur, F-75724 Paris, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Poyart
authors.affiliation: Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Poubeau
authors.affiliation: Centre Hospitalier Universitaire (CHU), F-97400, SaintPierre/Saint-Denis, La Réunion, France; Centre d'Investigation Clinique 1410 (Inserm/CHU/Université de La Réunion/Union Régionale des Médecins Libéraux de l'Océan Indien), F-97410, Saint Pierre, La Réunion; UMR PIMIT "Processus Infectieux en Milieu Insulaire Tropical" (Inserm 1187, CNRS 9192, IRD 249, Université de La Réunion), plateforme technologique CYROI, F-97490, Sainte Clotilde, La Réunion.
authors.forename: Patrick
authors.initials: P
authors.lastname: Gérardin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D017719:Diabetic Foot / Q000150:complications; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000150:complications; D011446:Prospective Studies; D017508:Reunion / Q000453:epidemiology; D012307:Risk Factors; D017192:Skin Diseases, Bacterial / Q000150:complications / Q000453:epidemiology; D018461:Soft Tissue Infections / Q000453:epidemiology; D013290:Streptococcal Infections / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000145:classification; D055815:Young Adult
keywords: Diabetes mellitus; Group B streptococcus; Incidence; Invasive disease; Tropical area