title: Management of egfr tki-induced dermatologic adverse events.
abstract: Targeting the epidermal growth factor receptor (egfr) pathway has become standard practice for the treatment of advanced non-small-cell lung cancer. Compared with chemotherapy, egfr tyrosine kinase inhibitors (tkis) have been associated with improved efficacy in patients with an EGFR mutation. Together with the increase in efficacy comes an adverse event (ae) profile different from that of chemotherapy. That profile includes three of the most commonly occurring dermatologic aes: acneiform rash, stomatitis, and paronychia. Currently, no randomized clinical trials have evaluated the treatments for the dermatologic aes that patients experience when taking egfr tkis. Based on the expert opinion of the authors, some basic strategies have been developed to manage those key dermatologic aes. Those strategies have the potential to improve patient quality of life and compliance and to prevent inappropriate dose reductions.
authors.affiliation: BC Cancer Agency, Vancouver, BC.
authors.forename: B
authors.initials: B
authors.lastname: Melosky
authors.affiliation: Princess Margaret Cancer Centre, University Health Network, Toronto, ON.
authors.forename: N B
authors.initials: NB
authors.lastname: Leighl
authors.affiliation: R.S. McLaughlin Durham Regional Cancer Centre, Lakeridge Health, Oshawa, and Department of Oncology, Queen's University, Kingston, ON.
authors.forename: J
authors.initials: J
authors.lastname: Rothenstein
authors.affiliation: Cross Cancer Institute, Edmonton, AB.
authors.forename: R
authors.initials: R
authors.lastname: Sangha
authors.affiliation: The Ottawa Hospital and University of Ottawa, Ottawa, ON.
authors.forename: D
authors.initials: D
authors.lastname: Stewart
authors.affiliation: Probity Medical Research, Waterloo, ON.
authors.forename: K
authors.initials: K
authors.lastname: Papp
keywords: Non-small-cell lung cancer; acneiform rash; adverse events; egfr tkis; paronychia; stomatitis