title: Chemical proteomics of host-pathogen interaction.
abstract: In less than two decades, activity-based protein profiling (ABPP) has expanded to become the de facto tool for the study of small molecule-protein interactions in a proteomic environment. In this issue, Na et al. (2015) present another ABPP method, which they called reactive probe-based chemical proteomics, to study host-pathogen interaction and subsequently identify the protein PheA as a potential key effector during the pathogen infection process.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
authors.forename: Jingyan
authors.initials: J
authors.lastname: Ge
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore. Electronic address: chmyaosq@nus.edu.sg.
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D011302:Prephenate Dehydratase / Q000378:metabolism*; D040901:Proteomics; D012480:Salmonella Infections / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D011302:Prephenate Dehydratase