title: The role of interleukin-1 gene polymorphisms and Helicobacter pylori in gastroesophageal reflux disease.
abstract: OBJECTIVE
  Our aim is to assess the relationship between interleukin 1β (IL-1 β), (-511,-31 alleles), interleukin 1RN (IL-RN), Helicobacter pylori (HP) status and gastroesophageal reflux disease (GERD) diagnosed by pH monitoring in the Turkish population.
  
  
  METHODS
  A Total of 100 consecutive patients with GERD were enrolled in the study. Genotypes of IL-1β (-511,-31), IL-1RN gene polymorphisms and HP status of the patients were analyzed.
  
  
  RESULTS
  While thirty-two patients were diagnosed as esophagitis with varying severity the remaining patients had no esophagitis. Seventy six participants were positive for HP and the remaining patients were negative. The difference between erosive and non-erosive groups was statistically significant when we compared IL-1β (-511) but no difference regarding IL-1β (-31) and IL-1RN variations. We also analyzed T/T, C/T and C/C alleles and the difference was significant statistically in T/T allele between patients with and without erosive GERD 1 (3.1%) vs. 12 (17.9%), respectively with a p value<0.05. But C/C, C/T alleles of (-511), (-31) and IL-1RN polymorphisms were not statistically significant between the groups.
  
  
  CONCLUSIONS
  IL-1β genetic polymorphisms may take part in the pathophysiology of gastroesophageal reflux disease.
authors.affiliation: Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey. drmustafacen@gmail.com.
authors.forename: Gülhan
authors.initials: G
authors.lastname: Akçil
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Doğan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cengiz
authors.forename: Evren Doruk
authors.initials: ED
authors.lastname: Engin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Doğan
authors.forename: Selahattin
authors.initials: S
authors.lastname: Ünal
authors.forename: Meltem Yalınay
authors.initials: MY
authors.lastname: Çırak
authors.forename: Ayşe
authors.initials: A
authors.lastname: Dursun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D004941:Esophagitis / Q000209:etiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000235:genetics* / Q000382:microbiology* / Q000473:pathology; D005838:Genotype; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta