title: The Potential for Plant Derivatives against Acrylamide Neurotoxicity.
abstract: Certain industrial chemicals and food contaminants have been demonstrated to possess neurotoxic activity and have been suspected to cause brain-related disorders in humans. Acrylamide (ACR), a confirmed neurotoxicant, can be found in trace amount in commonly consumed human aliments as a result of food processing or cooking. This discovery aroused a great concern in the public, and increasing efforts are continuously geared towards the resolution of this serious threat. The broad chemical diversity of plants may offer the resources for novel antidotes against neurotoxicants. With the goal of attenuating neurotoxicity of ACR, several plants extracts or derivatives have been employed. This review presents the plants and their derivatives that have been shown most active against ACR-induced neurotoxicity, with a focus on their origin, pharmacological activity, and antidote effects.
authors.affiliation: Cancer Research and Molecular Biology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.|Department of Chemical Sciences, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria.|Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
authors.forename: O O
authors.initials: OO
authors.lastname: Adewale
authors.affiliation: Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
authors.forename: J M
authors.initials: JM
authors.lastname: Brimson
authors.affiliation: Cancer Research and Molecular Biology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: O A
authors.initials: OA
authors.lastname: Odunola
authors.affiliation: Cancer Research and Molecular Biology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: M A
authors.initials: MA
authors.lastname: Gbadegesin
authors.affiliation: Cancer Research and Molecular Biology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: S E
authors.initials: SE
authors.lastname: Owumi
authors.affiliation: Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', Novara, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Isidoro
authors.affiliation: Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Tencomnao
mesh_terms: D029023:Acorus / Q000737:chemistry; D020106:Acrylamide / Q000633:toxicity*; D000080462:Acyclic Monoterpenes; D030024:Curcuma / Q000737:chemistry; D004220:Disulfides; D005419:Flavonoids / Q000494:pharmacology; D020939:Zingiber officinale / Q000737:chemistry; D006801:Humans; D039821:Monoterpenes / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D020258:Neurotoxicity Syndromes / Q000188:drug therapy*; D005894:Panax / Q000737:chemistry; D064209:Phytochemicals / Q000494:pharmacology*; D008517:Phytotherapy; D027542:Rosmarinus / Q000737:chemistry; D012431:Rutin / Q000494:pharmacology; D045730:Soy Foods; D013441:Sulfinic Acids / Q000494:pharmacology
chemical_list: D000080462:Acyclic Monoterpenes; D004220:Disulfides; D005419:Flavonoids; D039821:Monoterpenes; D018696:Neuroprotective Agents; D064209:Phytochemicals; D013441:Sulfinic Acids; D020106:Acrylamide; C006452:allicin; C043561:chrysin; D012431:Rutin; C018584:linalool
keywords: medicinal plants; neuroprotection; oxidative stress; plant products; reactive oxygen species