title: MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?
abstract: Despite advances in resuscitation medicine, including target temperature management as part of post-cardiac arrest care, many patients will have a poor neurological outcome, most often resulting in death. It is a commonly held belief that the ability to prognosticate outcome at an early stage after cardiac arrest would allow subsequent health care delivery to be tailored to individual patients. However, currently available predictive methods and biomarkers lack sufficient accuracy and therefore cannot be generally recommended in clinical practice. MicroRNAs have recently emerged as potential biomarkers of cardiovascular diseases. While the biomarker value of microRNAs for myocardial infarction or heart failure has been extensively studied, less attention has been devoted to their prognostic value after cardiac arrest. This review highlights the recent discoveries suggesting that microRNAs may be useful both to predict outcome and to treat patients after cardiac arrest.
authors.affiliation: Laboratory of Cardiovascular Research, Luxembourg Institute of Health, L-1526, Luxembourg, Luxembourg. yvan.devaux@crp-sante.lu.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Devaux
authors.affiliation: Department of Anaesthesia and Intensive Care Medicine, Centre Hospitalier, L-1445, Luxembourg, Luxembourg. Stammet.Pascal@chl.lu.
authors.forename: Pascal
authors.initials: P
authors.lastname: Stammet
authors.affiliation: Skane University Hospital, Lund University, SE-205 02, Malmo, Sweden. hans.friberg@skane.se.
authors.forename: Hans
authors.initials: H
authors.lastname: Friberg
authors.affiliation: Department of Cardiology, The Heart Center, Rigshospitalet, DK - 2100, Copenhagen, Denmark. Christian.hassager@rh.regionh.dk.
authors.forename: Christian
authors.initials: C
authors.lastname: Hassager
authors.affiliation: Department of Intensive Care Medicine, Medical Center Leeuwarden, 8934 AD, Leeuwarden, The Netherlands. m.kuiper@hccg-online.eu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kuiper
authors.affiliation: Adult Critical Care, University Hospital of Wales, Cardiff, CF14 4XW, UK. mattwise@doctors.org.uk.
authors.forename: Matt P
authors.initials: MP
authors.lastname: Wise
authors.affiliation: Helsingborg Hospital, Lund University, S-251 87, Helsingborg, Sweden. niklas.nielsen@telia.com.
authors.forename: Niklas
authors.initials: N
authors.lastname: Nielsen
mesh_terms: D015415:Biomarkers / Q000097:blood*; D016887:Cardiopulmonary Resuscitation; D003422:Critical Care; D006323:Heart Arrest / Q000097:blood* / Q000628:therapy; D006801:Humans; D007036:Hypothermia, Induced; D035683:MicroRNAs / Q000097:blood*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D035683:MicroRNAs