title: Long non-coding RNA functions in lung cancer.
abstract: Numerous long non-coding RNAs (lncRNAs) have been discovered as a result of advances in sequencing methods in genomic research. Recent evidence indicates that lncRNAs may serve as gene regulators via various mechanisms, such as translational control. Dysregulation of lncRNAs contributes to the development and progression of several human diseases, notably lung cancer, which is one of the leading causes of cancer-associated death. Recent studies have identified key roles for molecules such as p53 and polycomb repressive complex 2 (PRC2) in carcinogenesis and the anti-carcinogenic action of lncRNAs. These findings point to the potential of lncRNAs as prospective diagnostic and prognostic biomarkers in lung cancer. In this review, we consider the functions of lncRNAs in translational control and discuss their involvement in lung cancer via p53, PRC2, and other pathways. We also consider the effects of modulating the levels and functions of lncRNAs. Further characterization of these lung cancer-associated lncRNAs will provide a better understanding of their potential roles as therapeutic targets.
authors.affiliation: Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, Hubei, China.
authors.forename: Haiwei
authors.initials: H
authors.lastname: Sang
authors.forename: Haihong
authors.initials: H
authors.lastname: Liu
authors.forename: Peng
authors.initials: P
authors.lastname: Xiong
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
mesh_terms: D063646:Carcinogenesis / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D058990:Molecular Targeted Therapy; D063151:Polycomb Repressive Complex 2 / Q000235:genetics*; D014176:Protein Biosynthesis; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000627:therapeutic use; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D063151:Polycomb Repressive Complex 2