title: Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow-up analysis.
abstract: Oral lichen planus (OLP) carries an increased risk for malignant transformation with aneuploid cells (ACs) being found in brush samples of a quarter of patients with OLP.
  
  
  
  Patients with OLP were followed and repeated brush samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) using centromeric probes for chromosomes 2 and 8.
  
  
  
  Three patients with a high proportion of ACs developed oral cancer. Fifteen patients had ≥1% ACs (13 in affected sites and 2 in nonaffected sites), whereas only 2 of the 15 patients with <1% ACs in the first sample had ≥1% ACs in the second sample. A strong positive correlation between the results of the initial and repeated samples was found.
  
  
  
  High proportion of ACs in brush samples from patients with OLP may imply an impending malignant transformation. As FISH analysis is consistent over time, it can be used to identify a subgroup of patients who would require close follow-up. © 2015 Wiley Periodicals, Inc. Head Neck 38: E741-E746, 2016.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Ran
authors.initials: R
authors.lastname: Yahalom
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Chaim Sheba Medical Center, Tel Hashomer, Israel.|Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Noam
authors.initials: N
authors.lastname: Yarom
authors.affiliation: The Sackler Faculty of Medicine, and The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Tali
authors.initials: T
authors.lastname: Shani
authors.affiliation: Cancer Research Center, The Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Ninet
authors.initials: N
authors.lastname: Amariglio
authors.affiliation: Institute of Pathology, Rabin Medical Centre, Beilinson Campus, Petah-Tiqva, Israel.
authors.forename: Ilana
authors.initials: I
authors.lastname: Kaplan
authors.affiliation: Cancer Research Center, The Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Luba
authors.initials: L
authors.lastname: Trakhtenbrot
authors.affiliation: Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.|Cancer Research Center, The Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: Abraham
authors.initials: A
authors.lastname: Hirshberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002471:Cell Transformation, Neoplastic; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D017676:Lichen Planus, Oral / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics / Q000473:pathology*
keywords: aneuploidy; chromosomal instability; oral cancer; oral lichen planus