title: Rapid lung MRI - paradigm shift in evaluation of febrile neutropenia in children with leukemia: a pilot study.
abstract: Immunocompromised children with hematological malignancies are at increased risk of developing potentially fatal pulmonary infections. Early detection and prompt treatment is critical to combat morbidity and mortality in these children. Twenty-six children with leukemia (age range: 5-13years) presenting with fever and neutropenia were included in this prospective study, which was approved by the institutional ethics committee. All patients underwent HRCT and MRI of the chest on the same day. The findings of HRCT and MRI were compared, with HRCT as the standard of reference. There was perfect agreement between MRI and CT examinations findings by kappa test (κ = 1). No significant difference was observed between the two modalities by the McNemar test (p > 0.05). Rapid lung MRI is technically feasible; has a high correlation, sensitivity and specificity to CT scan; and can emerge as the first line modality for the detection of pulmonary nodules in children with leukemia and persistent febrile neutropenia.
authors.affiliation: a Department of Radio Diagnosis and Imaging , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Kushaljit Singh
authors.initials: KS
authors.lastname: Sodhi
authors.affiliation: a Department of Radio Diagnosis and Imaging , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Khandelwal
authors.affiliation: a Department of Radio Diagnosis and Imaging , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Akshay Kumar
authors.initials: AK
authors.lastname: Saxena
authors.affiliation: a Department of Radio Diagnosis and Imaging , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Anmol
authors.initials: A
authors.lastname: Bhatia
authors.affiliation: b Department of Paediatrics , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Bansal
authors.affiliation: b Department of Paediatrics , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Amita
authors.initials: A
authors.lastname: Trehan
authors.affiliation: b Department of Paediatrics , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Meenu
authors.initials: M
authors.lastname: Singh
authors.affiliation: c Department of Pulmonary Medicine , Post Graduate Institute of Medical Education and Research , Chandigarh , India.
authors.forename: Ritesh
authors.initials: R
authors.lastname: Agarwal
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D064147:Febrile Neutropenia / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008168:Lung / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D015203:Reproducibility of Results; D003074:Solitary Pulmonary Nodule / Q000473:pathology; D014057:Tomography, X-Ray Computed
keywords: CT scan; MRI; Pediatrics; imaging; leukemia; lung