title: Molecular deregulation of signaling in lymphoid tumors.
abstract: Genomic studies have led to a significant impact both on the pace and the nature of understanding the molecular and biological bases of a variety of lymphoid tumors. An increasingly emerging aspect from genomic studies is that malignant lymphoid cells manipulate signaling pathways that are central to the homeostasis of their normal counterpart, including B- and T-cell receptor signaling, NF-κB signaling, Toll-like receptor signaling, cytokine signaling, MAP kinase signaling, and NOTCH signaling. This review aims at covering the signaling pathways that are affected by mutations in lymphoid tumors, and how genetic alteration of these pathways may contribute to disease pathogenesis and management.
authors.affiliation: Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Spina
authors.affiliation: Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
authors.forename: Lavinia
authors.initials: L
authors.lastname: Martuscelli
authors.affiliation: Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Rossi
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D008223:Lymphoma / Q000235:genetics / Q000378:metabolism* / Q000628:therapy; D020935:MAP Kinase Signaling System; D016328:NF-kappa B / Q000378:metabolism; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D051880:Receptors, Notch; D051193:Toll-Like Receptors
keywords: B-cell receptor; MAP kinase; NF-κB; NOTCH; T-cell receptor; Toll-like receptor; chronic lymphocytic leukemia; lymphoma; mutation; signaling