title: Approaching 'Kit-Type' Labelling with (68)Ga: The DATA Chelators.
abstract: The DATA chelators are a novel class of tri-anionic ligands based on 6-amino-1,4-diazepine-triacetic acid, which have been introduced recently for the chelation of (68)Ga. Compared with macrocyclic chelators based on the cyclen scaffold (i.e., DOTA, DO3A, and DO2A derivatives), DATA chelators undergo quantitative radiolabelling more rapidly and under milder conditions. In this study, a systematic evaluation of the labelling of four DATA chelators--DATA(M), DATA(P), DATA(Ph), and DATA(PPh)--with (68)Ga is presented. The results highlight the extraordinary potential of this new class of chelators for application in molecular imaging using (68)Ga positron emission tomography (PET).
authors.affiliation: Institute of Nuclear Chemistry, Johannes Gutenberg University, Fritz-Strassmann-Weg 2, 55128 Mainz (Germany). Johanna.Seemann@uni-mainz.de.
authors.forename: Johanna
authors.initials: J
authors.lastname: Seemann
authors.affiliation: Institute of Nuclear Chemistry, Johannes Gutenberg University, Fritz-Strassmann-Weg 2, 55128 Mainz (Germany).|Department of Chemistry, Durham University, South Road, Durham, DH1 3LE (UK).
authors.forename: Bradley P
authors.initials: BP
authors.lastname: Waldron
authors.affiliation: Institute of Nuclear Chemistry, Johannes Gutenberg University, Fritz-Strassmann-Weg 2, 55128 Mainz (Germany).
authors.forename: Frank
authors.initials: F
authors.lastname: Roesch
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, DH1 3LE (UK).
authors.forename: David
authors.initials: D
authors.lastname: Parker
mesh_terms: D002614:Chelating Agents / Q000737:chemistry*; D005710:Gallium Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling; D007700:Kinetics
chemical_list: D002614:Chelating Agents; D005710:Gallium Radioisotopes
keywords: chelates; gallium-68; ligand design; macrocyclic ligands; radiopharmaceuticals