title: Regioselective metal-free one-pot synthesis of functionalized 2-aminothiophene derivatives.
abstract: A facile metal-free synthesis of 2-aminothiophene derivatives by the reaction of 2-ynals with thioamides in alcohols has been developed. This transformation allows the assembly of 2-aminothienyl ether derivatives via a well-designed aldol condensation/regioselective intramolecular cyclization/conjugate addition cascade reaction and provides a straightforward synthetic protocol for constructing 2,3,5-trisubstituted 2-aminothiophenes.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Luo
authors.forename: Li-Shi
authors.initials: LS
authors.lastname: Ge
authors.forename: Xing-Lan
authors.initials: XL
authors.lastname: An
authors.forename: Jing-Hai
authors.initials: JH
authors.lastname: Jin
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Sun
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Deng
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013854:Thioamides / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D013854:Thioamides; D013876:Thiophenes