title: Genetic polymorphisms associated with breast cancer in malaysian cohort.
abstract: Genome-wide association studies have discovered multiple single nucleotide polymorphisms (SNPs) associated with the risk of common diseases. The objective of this study was to demonstrate the replication of previously published SNPs that showed statistical significance for breast cancer in the Malaysian population. In this case-control study, 80 subjects for each group were recruited from various hospitals in Malaysia. A total of 768 SNPs were genotyped and analyzed to distinguish risk and protective alleles. A total of three SNPs were found to be associated with increased risk of breast cancer while six SNPs showed protective effect. All nine were statistically significant SNPs (p ≤ 0.01), five SNPs from previous studies were successfully replicated in our study. Significant modifiable (diet) and non-modifiable (family history of breast cancer in first degree relative) risk factors were also observed. We identified nine SNPs from this study to be either conferring susceptibility or protection to breast cancer which may serve as potential markers in risk prediction.
authors.affiliation: Molecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
authors.forename: Jagdish Kaur
authors.initials: JK
authors.lastname: Chahil
authors.affiliation: Molecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
authors.forename: Khamsigan
authors.initials: K
authors.lastname: Munretnam
authors.affiliation: Molecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
authors.forename: Nurulhafizah
authors.initials: N
authors.lastname: Samsudin
authors.affiliation: Molecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
authors.forename: Say Hean
authors.initials: SH
authors.lastname: Lye
authors.affiliation: Molecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
authors.forename: Nikman Adli Nor
authors.initials: NA
authors.lastname: Hashim
authors.affiliation: Molecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
authors.forename: Nurul Hanis
authors.initials: NH
authors.lastname: Ramzi
authors.affiliation: Molecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
authors.forename: Sharmila
authors.initials: S
authors.lastname: Velapasamy
authors.affiliation: Molecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
authors.forename: Ler Lian
authors.initials: LL
authors.lastname: Wee
authors.affiliation: Molecular Research and Services Laboratory, INFOVALLEY® Life Sciences Sdn. Bhd., Unit 101, Level 1, Block B, Mines Waterfront Business Park, No. 3, Jalan Tasik, 43300 MINES Resort City, Selangor Malaysia.
authors.forename: Livy
authors.initials: L
authors.lastname: Alex
keywords: Association; Breast cancer; Case–control study; Risk prediction model; SNP