title: Diagnostic value of coagulation factor and intracranial pressure monitoring in acute liver failure from heat stroke: case report and review of the literature.
abstract: BACKGROUND
  Exertional heat stroke (HS) with resultant acute liver failure (ALF) is a rare condition with high mortality. Diagnosis of ALF in the context of HS is confounded by numerous laboratory abnormalities related to multisystem organ dysfunction.
  
  
  METHODS
  We present the case of a 20-year-old male athlete with exertional HS who developed ALF and was treated successfully with orthotopic liver transplantation. He remained well after 1 year with normal liver function and no permanent neurologic impairment. Diagnosis and treatment was guided by serial monitoring of coagulation factors and intracranial pressure (ICP).
  
  
  CONCLUSIONS
  Currently, there are no well validated prognostic tools that predict the need for or survival with orthotopic liver transplantation for HS. We propose that serial monitoring of coagulation factors and, when safe and feasible, ICP monitoring may help to guide clinical decision making in this context.
authors.affiliation: Department of Internal Medicine, Banner Good Samaritan Medical Center, Phoenix, Arizona. Electronic address: mlramanathan@gmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Ramanathan
authors.affiliation: Department of Internal Medicine, Banner Good Samaritan Medical Center, Phoenix, Arizona.
authors.forename: M
authors.initials: M
authors.lastname: Pedersen
authors.affiliation: Department of Pathology, Banner Good Samaritan Medical Center, Phoenix, Arizona.
authors.forename: R
authors.initials: R
authors.lastname: Ramsey
authors.affiliation: Transplant and Advanced Liver Diseases, Banner Good Samaritan Medical Center, Phoenix, Arizona; University of Arizona College of Medicine, Phoenix, Arizona.
authors.forename: A
authors.initials: A
authors.lastname: Seetharam
mesh_terms: D001779:Blood Coagulation Factors / Q000502:physiology*; D001780:Blood Coagulation Tests; D018883:Heat Stroke / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007427:Intracranial Pressure; D017114:Liver Failure, Acute / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D018670:Monitoring, Ambulatory; D011379:Prognosis; D055815:Young Adult
chemical_list: D001779:Blood Coagulation Factors