title: Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case report.
abstract: BACKGROUND
  Malignant migrating partial seizures in infancy is a devastating pharmacoresistent epileptic encephalopathy of unknown etiology characterized by onset in the first 6 months of life, continuous migrating focal seizures with corresponding multifocal electroencephalographic discharges, developmental deterioration, and early mortality. Recent widespread interest in the nonpsychoactive component of the cannabis plant, cannabidiol, as a potential treatment for refractory devastating epilepsies has led to individual trials initiated by families or physicians in states that have legalized medical marijuana with anecdotal success.
  
  
  METHODS
  We describe a now 10-month-old boy with malignant migrating partial seizures in infancy who made developmental gains and demonstrated sustained seizure reduction with the addition of cannabidiol to his antiepileptic regimen.
  
  
  CONCLUSIONS
  This report supports a role for cannabidiol in the treatment of malignant migrating partial seizures in infancy.
authors.affiliation: Division of Pediatric Neurology, University of Iowa Children's Hospital, Iowa City, Iowa. Electronic address: dimah-saade@uiowa.edu.
authors.forename: Dimah
authors.initials: D
authors.lastname: Saade
authors.affiliation: Division of Pediatric Neurology, University of Iowa Children's Hospital, Iowa City, Iowa.
authors.forename: Charuta
authors.initials: C
authors.lastname: Joshi
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D002185:Cannabidiol / Q000627:therapeutic use*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D000927:Anticonvulsants; D002185:Cannabidiol
keywords: CBD; cannabidiol; ketogenic diet; malignant migrating partial epilepsy; migrating partial seizures