title: Copper-Catalyzed [4 + 1] Annulation between α-Hydroxy Ketones and Nitriles: An Approach to Highly Substituted 3(2H)-Furanones.
abstract: A copper-catalyzed [4 + 1] annulation between α-hydroxy ketones and nitriles has been developed. The reaction provides a facile and efficient method for the construction of a wide range of highly substituted 3(2H)-furanones, a class of important compounds known to be associated with several biological activities.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China.
authors.forename: Haitao
authors.initials: H
authors.lastname: He
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China.
authors.forename: Chaorong
authors.initials: C
authors.lastname: Qi
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Hu
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Ouyang
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China.
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xiong
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Lab of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China.
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
mesh_terms: D015107:4-Butyrolactone / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*
chemical_list: D007659:Ketones; D009570:Nitriles; D003300:Copper; D015107:4-Butyrolactone