title: Trophic effect of a methanol yeast extract on 3T3 fibroblast cells.
abstract: With regard to the increase of human life expectancy, interest for topical treatments aimed to counteract skin aging is still growing. Hence, research for bioactive compounds able to stimulate skin fibroblast activity is an attractive topic. Having previously described the effects of a new methanol yeast extract on growth and metabolic activity of Saccharomyces cerevisiae, we studied its effects on 3T3 fibroblasts to evaluate its potential antiaging property. This investigation demonstrates that this extract increases proliferation as well as migration of 3T3 cells and decreases their entrance in senescence and apoptosis phases. Altogether, these results open new perspectives for the formulation of innovative antiaging topical treatments.
authors.forename: Dominique
authors.initials: D
authors.lastname: Gallo
authors.forename: Monique
authors.initials: M
authors.lastname: Dillemans
authors.forename: David
authors.initials: D
authors.lastname: Allardin
authors.forename: Fabian
authors.initials: F
authors.lastname: Priem
authors.forename: Laurence
authors.initials: L
authors.lastname: Van Nedervelde
mesh_terms: D016475:3T3 Cells; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects*; D000432:Methanol; D051379:Mice; D012441:Saccharomyces cerevisiae / Q000737:chemistry* / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D000432:Methanol