title: Arachidonic acid diet attenuates brain Aβ deposition in Tg2576 mice.
abstract: The amyloid β-protein (Aβ) is believed to play a causative role in the development of Alzheimer's disease (AD). Because the amyloid precursor protein (APP), a substrate of Aβ, and β-secretase and γ-secretase complex proteins, which process APP to generate Aβ, are all membrane proteins, it is possible to assume that alterations in brain lipid metabolism modulate APP and/or Aβ metabolism. However, the role of polyunsaturated fatty acids in Aβ metabolism remains unknown. We report here that 9 months-treatment of Tg2576 mice with arachidonic acid (ARA)-containing (ARA+) diet prevented brain Aβ deposition in 17-month-old Tg2576 mice. APP processing to generate soluble APPα, CTF-β, and Aβ synthesis was attenuated in Tg2576 mice fed with the ARA+ diet. These findings suggest that ARA+ diet could prevent Aβ deposition through the alteration of APP processing in Tg2576 mice.
authors.affiliation: Department of Alzheimer׳s Disease Research, National Center for Geriatrics and Gerontology (NCGG), 35, Morioka, Obu, Aichi 474-8522, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Hosono
authors.affiliation: Department of Alzheimer׳s Disease Research, National Center for Geriatrics and Gerontology (NCGG), 35, Morioka, Obu, Aichi 474-8522, Japan.
authors.forename: Kazuchika
authors.initials: K
authors.lastname: Nishitsuji
authors.affiliation: Department of Alzheimer׳s Disease Research, National Center for Geriatrics and Gerontology (NCGG), 35, Morioka, Obu, Aichi 474-8522, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Alzheimer׳s Disease Research, National Center for Geriatrics and Gerontology (NCGG), 35, Morioka, Obu, Aichi 474-8522, Japan.
authors.forename: Cha-Gyun
authors.initials: CG
authors.lastname: Jung
authors.affiliation: Institute for Health Care Science, Suntory Wellness Ltd., Osaka, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Kontani
authors.affiliation: Institute for Health Care Science, Suntory Wellness Ltd., Osaka, Japan.
authors.forename: Hisanori
authors.initials: H
authors.lastname: Tokuda
authors.affiliation: Institute for Health Care Science, Suntory Wellness Ltd., Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawashima
authors.affiliation: Institute for Health Care Science, Suntory Wellness Ltd., Osaka, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kiso
authors.affiliation: Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Alzheimer׳s Disease Research, National Center for Geriatrics and Gerontology (NCGG), 35, Morioka, Obu, Aichi 474-8522, Japan; Department of Biochemistry, Nagoya City University, School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan. Electronic address: michi@med.nagoya-cu.ac.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Michikawa
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000517:prevention & control; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid / Q000008:administration & dosage*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D004032:Diet; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids / Q000008:administration & dosage; D005260:Female; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid
keywords: APP-Tg mouse; Alzheimer׳s disease; Arachidonic acid; Aβ deposition; PUFA