title: Lactobacillus fermentum 3872 genome sequencing reveals plasmid and chromosomal genes potentially involved in a probiotic activity.
abstract: In this report we describe a Lactobacillus fermentum 3872 plasmid (pLF3872) not previously found in any other strain of this species. The analysis of the complete sequence of this plasmid revealed the presence of a gene encoding a large collagen-binding protein (CBP), as well as the genes responsible for plasmid maintenance and conjugation. Potential roles of CBP and a chromosomally encoded fibronectin-binding protein (FbpA) in probiotic activity are discussed.
authors.affiliation: School of Life Sciences, SEC Faculty, Kingston University, Kingston upon Thames KT1 2EE, UK.
authors.forename: B
authors.initials: B
authors.lastname: Lehri
authors.affiliation: School of Life Sciences, SEC Faculty, Kingston University, Kingston upon Thames KT1 2EE, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Seddon
authors.affiliation: School of Life Sciences, SEC Faculty, Kingston University, Kingston upon Thames KT1 2EE, UK a.karlyshev@kingston.ac.uk.
authors.forename: A V
authors.initials: AV
authors.lastname: Karlyshev
mesh_terms: D018829:Adhesins, Bacterial / Q000235:genetics; D001422:Bacterial Adhesion / Q000235:genetics; D002876:Chromosomes, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D052197:Limosilactobacillus fermentum / Q000235:genetics*; D008969:Molecular Sequence Data; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000235:genetics; D010957:Plasmids / Q000235:genetics*; D019936:Probiotics; D017422:Sequence Analysis, DNA
chemical_list: D018829:Adhesins, Bacterial; C078635:fibronectin-binding proteins, bacterial; D009238:N-Acetylmuramoyl-L-alanine Amidase
keywords: Lactobacillus fermentum; adhesion; collagen binding protein; conjugative plasmid; host cell receptors; peptidoglycan hydrolase; probiotics