title: CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma.
abstract: BACKGROUND
  The objective of this study was to investigate the expression and clinical role of 14 genes previously shown to be associated with chemotherapy response and/or progression-free survival in a smaller series of ovarian serous carcinoma effusions.
  
  
  METHODS
  Advanced-stage serous ovarian carcinoma effusions (n = 150) were analyzed for mRNA expression of AKR1C1, ABCA4, ABCA13, ABCB10, BIRC6, CASP9, CIAPIN1, FAS, MGMT, MUTYH, POLH, SRC, TBRKB and XPA using quantitative real-time PCR. mRNA expression was studied for association with clinicopathologic parameters, including chemotherapy response and survival.
  
  
  RESULTS
  ABCA4 mRNA expression was significantly related to better (complete) chemotherapy response at diagnosis in the entire cohort (p = 0.018), whereas higher POLH mRNA levels were significantly related to better chemoresponse at diagnosis in analysis to 58 patients with pre-chemotherapy effusions treated with standard chemotherapy (carboplatin + paclitaxel; p = 0.023). In univariate survival analysis for patients with pre-chemotherapy effusions (n = 77), CIAPIN1 mRNA expression was significantly related to shorter overall (p = 0.007) and progression-free (p = 0.038) survival, whereas ABCA13 mRNA expression was significantly related to shorter OS (p = 0.024). Higher CIAPIN1 mRNA expression was an independent marker of poor overall survival in Cox multivariate analysis (p = 0.044).
  
  
  CONCLUSIONS
  Our data identify ABCA4 and POLH as markers of better chemotherapy response in metastatic serous carcinoma. CIAPIN1 and ABCA13 may be novel markers of poor outcome in pre-chemotherapy serous carcinoma effusions.
authors.affiliation: Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway. dnymoen@ous-hf.no.
authors.forename: Dag Andre
authors.initials: DA
authors.lastname: Nymoen
authors.affiliation: Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway. ARILH@ous-hf.no.
authors.forename: Arild
authors.initials: A
authors.lastname: Holth
authors.affiliation: Department of Oncology, Oslo University Hospital, Norwegian Radium Hospital, N-0310, Oslo, Norway. THEHET@ous-hf.no.
authors.forename: Thea E
authors.initials: TE
authors.lastname: Hetland Falkenthal
authors.affiliation: Department of Gynecologic Oncology, Oslo University Hospital, Norwegian Radium Hospital, N-0310, Oslo, Norway. c.g.trope@medisin.uio.no.|University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, N-0316, Oslo, Norway. c.g.trope@medisin.uio.no.
authors.forename: Claes G
authors.initials: CG
authors.lastname: Tropé
authors.affiliation: Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway. bend@medisin.uio.no.|University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, N-0316, Oslo, Norway. bend@medisin.uio.no.
authors.forename: Ben
authors.initials: B
authors.lastname: Davidson
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics*; D000077216:Carcinoma, Ovarian Epithelial; D018284:Cystadenocarcinoma, Serous / Q000235:genetics* / Q000401:mortality*; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics* / Q000401:mortality*; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000401:mortality*; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics
chemical_list: C473800:ABCA13 protein, human; D018528:ATP-Binding Cassette Transporters; D014408:Biomarkers, Tumor; C489114:CIAPIN1 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D012333:RNA, Messenger