title: Detection of a 640-bp deletion in the Aggregatibacter actinomycetemcomitans leukotoxin promoter region in isolates from an adolescent of Ethiopian origin.
abstract: The expression of the leukotoxin of Aggregatibacter actinomycetemcomitans is regulated by the leukotoxin promoter. A 530-bp deletion or an 886-bp insertion sequence (IS) element in this region has earlier been described in highly leukotoxic isolates. Here, we report on highly leukotoxic isolate with a 640-bp deletion, which was detected in an adolescent of Ethiopian origin.
authors.affiliation: Division of Oral Microbiology, Department of Odontology, Umeå University, Umeå, Sweden; rolf.claesson@odont.umu.se.
authors.forename: Rolf
authors.initials: R
authors.lastname: Claesson
authors.affiliation: Periodontology Specialist Clinic, Östersunds Hospital, Östersund, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Gudmundson
authors.affiliation: Division of Molecular Periodontology, Department of Odontology, Umeå University, Umeå, Sweden.
authors.forename: Carola Höglund
authors.initials: CH
authors.lastname: Åberg
authors.affiliation: Section for Pediatric Dentistry, Department of Dentistry, Health, Aarhus University, Aarhus, Denmark.
authors.forename: Dorte
authors.initials: D
authors.lastname: Haubek
authors.affiliation: Division of Molecular Periodontology, Department of Odontology, Umeå University, Umeå, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Johansson
keywords: Africa; JP2; aggressive periodontitis; deletion; geographic spreading; leukotoxicity