title: Chorioamnionitis in pregnancy: a comparative study of HIV-positive and HIV-negative parturients.
abstract: Chorioamnionitis is an important risk factor for vertical transmission of HIV/AIDS. We compared the prevalence and correlates of histologic chorioamnionitis (HCA) in HIV-positive and HIV-negative pregnant women. HIV-positive and -negative parturients were interviewed, examined and had their placentas examined histologically for chorioamnionitis. Data regarding HIV were also retrieved from their hospital records. A total of 298 parturients (150 HIV positive and 148 HIV negative) were enrolled. The two groups were similar in socio-demographic and obstetric parameters except for age. The prevalence of HCA was 57.1% in HIV-positive women and 61.6% in HIV-negative women (p = 0.43). HCA staging was associated with the number of intrapartum vaginal examinations in HIV-positive subjects and nulliparity in HIV-negative subjects. The number of intrapartum vaginal examinations and coitus in the week prior to delivery significantly affected the grade of HCA in HIV-negative subjects. The prevalence of HCA in both HIV-positive and HIV-negative is high. Most variables did not affect the occurrence of HCA in both groups studied except number of intrapartum examinations, coitus in the preceding one week and nulliparity, which were related to severity of the disease.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Jos/Jos University Teaching Hospital, Jos, Nigeria amakaocheke@yahoo.com.
authors.forename: Amaka N
authors.initials: AN
authors.lastname: Ocheke
authors.affiliation: Department of Family Medicine, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Agaba
authors.affiliation: Department of Obstetrics and Gynaecology, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: Godwin E
authors.initials: GE
authors.lastname: Imade
authors.affiliation: Department of Histopathology, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: Olugbenga A
authors.initials: OA
authors.lastname: Silas
authors.affiliation: Department of Histopathology, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: Olanrewaju I
authors.initials: OI
authors.lastname: Ajetunmobi
authors.affiliation: Department of Histopathology, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: Godwins
authors.initials: G
authors.lastname: Echejoh
authors.affiliation: Department of Obstetrics and Gynaecology, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: Clement
authors.initials: C
authors.lastname: Ekere
authors.affiliation: Department of Obstetrics and Gynaecology, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: Ayuba
authors.initials: A
authors.lastname: Sendht
authors.affiliation: Department of Obstetrics and Gynaecology, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: James
authors.initials: J
authors.lastname: Bitrus
authors.affiliation: Department of Medicine, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: Emmanuel I
authors.initials: EI
authors.lastname: Agaba
authors.affiliation: Department of Obstetrics and Gynaecology, University of Jos/Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: Atiene S
authors.initials: AS
authors.lastname: Sagay
mesh_terms: D002821:Chorioamnionitis / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications*; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D011256:Pregnancy Outcome
keywords: AIDS; HIV; chorioamnionitis; histologic chorioamnionitis; obstetric; parturients; placenta; women