title: Nuclear Receptor Coregulators in Metabolism and Disease.
abstract: Within the past two decades, coregulators have emerged as essential chromatin components of metabolic signaling by nuclear receptors and additional metabolite-sensing transcription factors. Intriguingly, coregulators themselves are efficient sensors and effectors of metabolic stimuli that modulate gene expression at different levels, often via post-translational modifications of histones or other factors. There is already evidence that alterations of expression or function of coregulators contributes to metabolic disease by propagating disease-specific epigenomes linked to the dysregulation of transcription and downstream pathways. In this chapter we review the current progress made in understanding the role of coregulators in metabolic pathways, with a particular emphasis on their study in vivo and in the context of metabolic disease.
authors.affiliation: Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, S-14157, Sweden.
authors.forename: Marco
authors.initials: M
authors.lastname: Giudici
authors.affiliation: Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, S-14157, Sweden.
authors.forename: Saioa
authors.initials: S
authors.lastname: Goni
authors.affiliation: Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, S-14157, Sweden.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Fan
authors.affiliation: Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, S-14157, Sweden. eckardt.treuter@ki.se.
authors.forename: Eckardt
authors.initials: E
authors.lastname: Treuter
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D006801:Humans; D007333:Insulin Resistance; D008659:Metabolic Diseases / Q000209:etiology*; D018482:Muscle, Skeletal / Q000378:metabolism; D009928:Organ Specificity; D011499:Protein Processing, Post-Translational; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear
keywords: Coregulators; Inflammation; Metabolic disease; Metabolism; Nuclear receptors