title: Changing paradigms in the management of deep vein thrombosis.
abstract: In adults diagnosed with deep vein thrombosis (DVT), challenges remain in the management of the acute event whilst remaining alert to long-term morbidity. The addition of non-vitamin K antagonist oral anticoagulants (NOACs) to the pharmacopoeia represents the first of a number of recent advancements in the management of DVT. Worldwide, uptake of these agents has been avid, although drug selection, reversal and chronic treatment effects continue to be controversial areas. Multi-centre studies to evaluate the impact of NOACs on long-term outcomes, including thrombosis recurrence and post-thrombotic syndrome (PTS), are ongoing. Validation of tools capable of predicting PTS would enable patient selection for early aggressive intervention, such as local thrombolysis. Such interventional strategies are gaining momentum as initial approaches and would benefit from large randomized controlled trials.
authors.affiliation: King's Thrombosis Centre, King's College Hospital NHS Foundation Trust, London, UK.
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Lang
authors.affiliation: Guy's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
authors.forename: Prakash
authors.initials: P
authors.lastname: Saha
authors.affiliation: King's Thrombosis Centre, King's College Hospital NHS Foundation Trust, London, UK.
authors.forename: Lara N
authors.initials: LN
authors.lastname: Roberts
authors.affiliation: King's Thrombosis Centre, King's College Hospital NHS Foundation Trust, London, UK.
authors.forename: Roopen
authors.initials: R
authors.lastname: Arya
mesh_terms: D000465:Algorithms; D003952:Diagnostic Imaging / Q000379:methods; D019468:Disease Management; D006801:Humans; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000628:therapy*
keywords: anticoagulation; deep vein thrombosis; non-vitamin K antagonist oral anticoagulant(s); post-thrombotic syndrome; thrombolysis