title: Circadian actigraphic rest-activity rhythms following surgery for endometrial cancer: A prospective, longitudinal study.
abstract: OBJECTIVE
  To investigate (1) circadian rest-activity rhythm disturbances among endometrial cancer patients as they recover from surgery in comparison to a historical reference group of women with no cancer history and (2) health- and treatment-related predictors of dysregulated rest-activity rhythms in endometrial cancer patients.
  
  
  METHODS
  60 endometrial cancer patients participated in a prospective, longitudinal study with actigraphic assessment at 1week, 1month, and 4months post-surgery. 60 women without cancer from an epidemiological sample completed one actigraphic assessment, acting as a reference group.
  
  
  RESULTS
  On average, results revealed initial significant rest-activity dysregulation at 1week and 1month post-surgery for the endometrial cancer group and then significant recovery in rest-activity patterns at 4months post-surgery. Similarly, the cancer group had significantly more impaired rhythms than the reference group at 1week post-surgery, but demonstrated comparable rhythms by 4months post-surgery. Among the health- and treatment-related variables examined, obesity and receipt of more invasive surgery were found to predict more impaired rhythms at all time points.
  
  
  CONCLUSIONS
  The current study highlights significant disturbances in rest-activity patterns for endometrial cancer patients initially during surgical recovery followed by improvement in these patterns by 4months post-surgery; however, obese patients and those having more invasive surgery demonstrated more impaired rest-activity patterns throughout the 4-month recovery period. Further research is warranted to understand how more impaired rest-activity patterns relate to health and quality of life outcomes.
authors.affiliation: Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. Electronic address: rumble@wisc.edu.
authors.forename: Meredith E
authors.initials: ME
authors.lastname: Rumble
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Rose
authors.affiliation: Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: Kaitlin Hanley
authors.initials: KH
authors.lastname: White
authors.affiliation: Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: A Holliston
authors.initials: AH
authors.lastname: Moore
authors.affiliation: Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Philip
authors.initials: P
authors.lastname: Gehrman
authors.affiliation: Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Benca
authors.affiliation: Department of Psychiatry, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
authors.forename: Erin S
authors.initials: ES
authors.lastname: Costanzo
mesh_terms: D056044:Actigraphy / Q000379:methods; D002940:Circadian Rhythm / Q000502:physiology*; D016889:Endometrial Neoplasms / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D011446:Prospective Studies
keywords: Actigraphy; Circadian activity rhythm; Endometrial cancer; Laparoscopic; Laparotomy; Obesity