title: Inflammation in HFpEF: Key or circumstantial?
abstract: Heart failure (HF) can be split into HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Currently the pathophysiologic mechanisms involved in HFpEF remain largely unknown. The neurohumoral and sympathetic nervous systems seem not to play a crucial role in HFpEF, as treatments targeting these pathways do not show beneficial effects in HFpEF patients, in contrast to HFrEF patients. A better understanding of the pathophysiological processes involved in HFpEF is needed, as there is no proven treatment for this disease at the moment. Recent data have yielded growing attention to the role of inflammation in HFpEF. In this review we discuss increased inflammation in HFpEF as demonstrated in translational animal models and human studies. This review evaluates whether inflammation plays a key role in HFpEF or is just a by-product of various comorbidities. Additionally, we analyze the involvement of oxidative stress and endothelial dysfunction and lastly we outline potential therapeutic targets.
authors.affiliation: Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands. Electronic address: Vanessa.Van.Empel@mumc.nl.
authors.forename: Vanessa
authors.initials: V
authors.lastname: van Empel
authors.affiliation: Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Brunner-La Rocca
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002303:Cardiac Output, Low / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008297:Male; D018384:Oxidative Stress; D011379:Prognosis; D013318:Stroke Volume / Q000502:physiology*; D020257:Ventricular Remodeling / Q000502:physiology
chemical_list: D015415:Biomarkers
keywords: Endothelial dysfunction; Heart failure; Heart failure with preserved ejection fraction; Heart failure with reduced ejection fraction; Inflammation; Oxidative stress