title: Synthesis and Biological Activities of Organotin(IV) Complexes as Antitumoral and Antimicrobial Agents. A Review.
abstract: Advances in the use of organotin(IV) compounds have gained relevant interest in both the chemical and pharmaceutical industry. Tin(IV) form stable complexes with a unique structure and physicochemical properties that are used in organic synthesis as heat stabilizers and catalysts, in drug development as biologically active agents, and in other areas. This review focuses on recent progress in the classical and convenient synthesis procedure, on their mechanism of action, and biological activities as antitumoral and antimicrobial agents.
authors.forename: Syed Shoaib Ahmad
authors.initials: SS
authors.lastname: Shah
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashfaq
authors.forename: Amir
authors.initials: A
authors.lastname: Waseem
authors.forename: M Mehboob
authors.initials: MM
authors.lastname: Ahmed
authors.forename: Tayyaba
authors.initials: T
authors.lastname: Najam
authors.forename: Salma
authors.initials: S
authors.lastname: Shaheen
authors.affiliation: Centro de Biotecnologia Genomica, Instituto Politecnico Nacional, Boulevard del Maestro, s/n, Esq. Elías Pina, Reynosa, 88710, Mexico. gildardors@hotmail.com.
authors.forename: Gildardo
authors.initials: G
authors.lastname: Rivera
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D009947:Organotin Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D009947:Organotin Compounds