title: Ischemia in pelvic organs as an independent pathogenic factor in the development of benign prostatic hyperplasia and urinary bladder dysfunction.
abstract: Blood supply to the pelvic organs of outbred male rats was diminished by graduated constriction of the distal part of the inferior vena cava. Deficiency of intramural blood supply in prostate and urinary bladder was revealed by bioimpedance harmonic analysis according to the magnitude of first cardiac peak in the bioimpedance spectrogram. In 1-1.5 months, the histological examination revealed the glandular-stromal form of progressive benign prostatic hyperplasia in all ischemic rats. The development of hyperplasia was not accompanied by the changes in testosterone, dihydrotestosterone, or estradiol in blood and prostatic tissue. Assessment of vesical functional status by recording the intravesical pressure during infusion cystometry revealed an increase in the amplitude of spontaneous fluctuations of detrusor tone and intravesical pressure during bladder filling, which can be considered as indicator of detrusor hyperactivity. The data conclude that chronic ischemia of pelvic organs is an individual pathogenic factor in the development of benign prostatic hyperplasia and associated urinary disorders.
authors.affiliation: Department of Experimental Modeling of Urological Diseases, Research Institute of Urology, Russian Ministry of Health, Moscow, Russia, vladkirp@yandex.ru.
authors.forename: V I
authors.initials: VI
authors.lastname: Kirpatovskii
authors.forename: I S
authors.initials: IS
authors.lastname: Mudraya
authors.forename: K G
authors.initials: KG
authors.lastname: Mkrtchyan
authors.forename: S V
authors.initials: SV
authors.lastname: Revenko
authors.forename: G D
authors.initials: GD
authors.lastname: Efremov
authors.forename: O N
authors.initials: ON
authors.lastname: Nadtochii
authors.forename: I V
authors.initials: IV
authors.lastname: Kabanova
mesh_terms: D000818:Animals; D013196:Dihydrotestosterone / Q000097:blood / Q000378:metabolism; D004958:Estradiol / Q000097:blood / Q000378:metabolism; D007511:Ischemia / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D008297:Male; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000097:blood / Q000209:etiology / Q000473:pathology*; D051381:Rats; D013739:Testosterone / Q000097:blood / Q000378:metabolism; D001743:Urinary Bladder / Q000473:pathology*; D014682:Vena Cava, Inferior / Q000378:metabolism / Q000473:pathology
chemical_list: D013196:Dihydrotestosterone; D013739:Testosterone; D004958:Estradiol