title: [Optimize extraction technology of Fufang Bajitian Shenggu Particles by central composite design and response surface method].
abstract: OBJECTIVE
  To optimize extraction process of Fufang Bajitian Shenggu Particles by central composite design and response surface method.
  
  
  METHODS
  The preparation of Fufang Bajitian Shenggu Particles was designed according to the test. With the overall desirability (OD) of Icariin content and the dry extract yield in medicinal materials extract concentrate as examining indexes, immersion time, material liquid ratio, extraction time and stress concentration temperature were investigated. Based on the single factor tests, material liquid ratio, extraction time and stress concentration temperature which impacted response values significantly were investigated by three factors and five levels of central composite design.
  
  
  RESULTS
  Optimum extraction technology of Fufang Bajitian Shenggu Particles were as follows: material liquid ratio was 1:11.33, extraction time was 39 min, and stress concentration temperature was 66 °C. Bias of the lcariin content and the dry extract yield between observed and predicted values were 1.60% and 1.55% ,respectively.
  
  
  CONCLUSIONS
  Using central composite design and response surface method to optimize extraction of Fufang Bajitian Shenggu particles has a good prediction.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Sha
authors.initials: S
authors.lastname: Ji
authors.forename: Jin-juan
authors.initials: JJ
authors.lastname: Gao
authors.forename: Jin-xian
authors.initials: JX
authors.lastname: Yan
authors.forename: He-ming
authors.initials: HM
authors.lastname: Wang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000737:chemistry*; D013678:Technology, Pharmaceutical; D013696:Temperature
chemical_list: D005419:Flavonoids; C056599:icariin