title: Fas and FasL expression in placentas complicated with intrauterine growth retardation with and without preeclampsia.
abstract: OBJECTIVE
  To compare the level of Fas and FasL immunohistochemical expression in villous trophoblast (VT), extravillous trophoblast (EVT) cells, decidual cells (DC), endothelial cells (EC) of villous blood vessels and spiral arteries between the study groups of intrauterine growth retardation (IUGR) placentas with and without preeclampsia (PE).
  
  
  METHODS
  The study included 17 placentas from pregnancies complicated by IUGR + PE and 17 placentas from pregnancies complicated by idiopathic IUGR (I-IUGR). Seventeen placentas from normal pregnancies served as a control group. CD31 was used to detect endothelial cells (EC). Immunohistochemical expression of Fas and FasL was assessed in all examined parts of placenta using the semi-quantitative HSCORE method.
  
  
  RESULTS
  FasL expression was significantly higher in all examined parts of placenta in I-IUGR as compared to IUGR + PE and control group. Placentas with IUGR + PE had the significantly lowest expression of FasL in VT and EC of villi vessels. Expression of Fas did not differ significantly between the study groups.
  
  
  CONCLUSIONS
  Different expression of FasL in placentas from I-IUGR and IUGR + PE suggests that FasL probably has a different role in the etiology of these two syndromes.
authors.affiliation: a Clinical Department of Gynecology and Obstetrics and.
authors.forename: Jasminka
authors.initials: J
authors.lastname: Rešić Karara
authors.affiliation: b Clinical Department of Pathology , Split University Hospital Center , Split , Croatia.
authors.forename: Sandra
authors.initials: S
authors.lastname: Zekić Tomas
authors.affiliation: a Clinical Department of Gynecology and Obstetrics and.
authors.forename: Jelena
authors.initials: J
authors.lastname: Marušić
authors.affiliation: a Clinical Department of Gynecology and Obstetrics and.
authors.forename: Damir
authors.initials: D
authors.lastname: Roje
authors.affiliation: b Clinical Department of Pathology , Split University Hospital Center , Split , Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Kuzmić Prusac
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D053222:Fas Ligand Protein / Q000378:metabolism*; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011225:Pre-Eclampsia / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D014327:Trophoblasts / Q000378:metabolism; D055815:Young Adult; D019014:fas Receptor / Q000378:metabolism*
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D019014:fas Receptor
keywords: Fas; Fas ligand; intrauterine growth retardation; preeclampsia