title: Serum posaconazole levels during acute myeloid leukaemia induction therapy: correlations with breakthrough invasive fungal infections.
abstract: The usefulness of posaconazole therapeutic drug monitoring (TDM) is still a matter of debate. A correlation between posaconazole serum levels and breakthrough invasive fungal infections (IFI) has not been clearly demonstrated so far. We analysed posaconazole serum levels in patients with acute myeloid leukaemia (AML) during induction therapy and correlated them with the incidence of breakthrough IFI and the need of systemic antifungal therapy. Overall, 77 AML patients receiving posaconazole were evaluated for serum levels; breakthrough IFI were observed in five with at least one posaconazole TDM (6.5%). Median serum level was 534 ng ml(-1) (IQ range: 298.5-750.5 ng ml(-1) ) and did not change significantly over time. Four of the 40 patients with median posaconazole levels <500 ng ml(-1) developed IFI, as compared with only 1 of the 37 patients with median levels ≥500 (10% vs. 2.7%, P = 0.19). Median posaconazole levels on day 7 were 384.5 ng ml(-1) (IQ range: 207-659 ng ml(-1) ) and 560.5 ng ml(-1) (IQ range: 395-756 ng ml(-1) ) in patients requiring or not systemic antifungal treatment respectively (P = 0.067). These results seem to confirm that higher median serum levels of posaconazole correlate with higher prophylactic efficacy against proven/probable IFI and with lesser need of systemic antifungal therapy.
authors.affiliation: Hematology, Spedali Civili, Brescia, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Cattaneo
authors.affiliation: Laboratory of Hormonology and Toxicology, Spedali Civili, Brescia, Italy.
authors.forename: Annafranca
authors.initials: A
authors.lastname: Panzali
authors.affiliation: Hematology, Spedali Civili, Brescia, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Passi
authors.affiliation: Hematology, Spedali Civili, Brescia, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Borlenghi
authors.affiliation: Hematology, Spedali Civili, Brescia, Italy.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Lamorgese
authors.affiliation: Hematology, Spedali Civili, Brescia, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Petullà
authors.affiliation: Hematology, Spedali Civili, Brescia, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Re
authors.affiliation: Laboratory of Hormonology and Toxicology, Spedali Civili, Brescia, Italy.|Clinical Biochemistry, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Caimi
authors.affiliation: Hematology, Spedali Civili, Brescia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rossi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D016469:Fungemia / Q000453:epidemiology* / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D060828:Induction Chemotherapy; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000737:chemistry; D014230:Triazoles / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D014230:Triazoles; C101425:posaconazole
keywords: Acute leukaemia; invasive fungal infections; posaconazole prophylaxis; therapeutic drug monitoring