title: A unified model for bone-renal mineral and energy metabolism.
abstract: The beginning of the millennium saw the discovery of a new bone-matrix protein, Matrix Extracellular PhosphoglycoprotEin (MEPE) and an associated C-terminal motif called ASARM. This motif and other distinguishing features occur in a group of proteins called SIBLINGs. These proteins include dentin matrix protein 1 (DMP1), osteopontin, dentin-sialophosphoprotein (DSPP), statherin, bone sialoprotein (BSP) and MEPE. MEPE, DMP1 and ASARM-motifs regulate expression of a phosphate regulating cytokine FGF23. Further, a trimeric interaction between phosphate regulating endopeptidase homolog X-linked (PHEX), DMP1, and α5β3-integrin that occurs on the plasma-membrane of the osteocyte mediates FGF23 regulation (FAP pathway). ASARM-peptides competitively inhibit the trimeric complex and increase FGF23. A second pathway involves specialized structures, matrix vesicles pathway (MVP). This review will discuss the FAP and MVP pathways and present a unified model for mineral and energy metabolism.
authors.affiliation: Department of Internal Medicine, The Kidney Institute & Division of Nephrology, MS 3018, University of Kansas Medical Center, 3901 Rainbow Boulevard, 6020(B) Wahl Hall East, Kansas City, KS 66160, USA. Electronic address: prowe@kumc.edu.
authors.forename: Peter S
authors.initials: PS
authors.lastname: Rowe
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002113:Calcification, Physiologic / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D000089703:Fibroblast Growth Factor-23; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism
chemical_list: D016326:Extracellular Matrix Proteins; C000717427:FGF23 protein, human; D006023:Glycoproteins; C486579:MEPE protein, human; D010750:Phosphoproteins; D000089703:Fibroblast Growth Factor-23