title: NLRP3, a Double-edged Sword in Lung Injury Diseases.
abstract: Nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) plays a key role in lung injury diseases regulation, and its expression is increased in lung injury diseases. NLRP3 may be a good therapeutic target for lung injury diseases. The molecular mechanisms of NLRP3 in lung injury diseases remain unclear. It is a key to study the potential mechanism of NLRP3 during lung injury diseases, so that to exploit it as a good target for lung injury diseases therapy.
authors.affiliation: Department of Cardiothoracic Surgery, The Second Hospital of Anhui Medical University, Fu Rong Road, Hefei, Anhui Province, China, 230601.
authors.forename: Jun-Xu
authors.initials: JX
authors.lastname: Wu
authors.forename: Kai-Hu
authors.initials: KH
authors.lastname: Shi
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D006801:Humans; D055370:Lung Injury / Q000175:diagnosis / Q000378:metabolism*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein
chemical_list: D002352:Carrier Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human