title: Disabling the platelet's brakes to promote thrombosis.
abstract: In this issue of Blood, Magwenzi et al from the University of Hull report a novel mechanistic connection between oxidized low-density lipoprotein (oxLDL)-induced prothrombotic platelet signaling and the inhibition of endogenous platelet anti-activating signaling mediated by the nitric oxide (NO)/guanosine 3′,5′-cyclic monophosphate (cGMP)/protein kinase G (PKG) pathway.
authors.affiliation: MEDICAL COLLEGE OF WISCONSIN.
authors.forename: Roy L
authors.identifier: http://orcid.org/0000-0001-7859-9154
authors.initials: RL
authors.lastname: Silverstein
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology*; D018955:CD36 Antigens / Q000378:metabolism*; D017869:Cyclic GMP-Dependent Protein Kinases / Q000378:metabolism*; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D019255:NADPH Oxidases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D018955:CD36 Antigens; D008077:Lipoproteins, LDL; D008562:Membrane Glycoproteins; D019255:NADPH Oxidases; D017869:Cyclic GMP-Dependent Protein Kinases