title: Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection.
abstract: Currently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reaches the infant's cerebrospinal fluid when used at the currently recommended dose for congenital cytomegalovirus infection.
authors.affiliation: Department of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. fab.natale@libero.it.|Neonatal Intensive Care Unit, Department of Pediatrics and Child Neuropsychiatry, "Sapienza" University of Rome, V.le Regina Elena 324, 00161, Rome, Italy. fab.natale@libero.it.
authors.forename: Fabio
authors.initials: F
authors.lastname: Natale
authors.affiliation: Department of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. bizzarribianca@gmail.com.
authors.forename: Bianca
authors.initials: B
authors.lastname: Bizzarri
authors.affiliation: Department of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. veronica.cardi@gmail.com.
authors.forename: Veronica
authors.initials: V
authors.lastname: Cardi
authors.affiliation: Laboratory of Virology, Department of Public Health and Infectious Diseases, "La Sapienza" University of Rome, Rome, Italy. aurelia.gaeta@uniroma1.it.
authors.forename: Aurelia
authors.initials: A
authors.lastname: Gaeta
authors.affiliation: Department of Pharmacology, IRCCS Policlinico S. Matteo, Pavia, Italy. paolavillani2003@libero.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Villani
authors.affiliation: I.N.M.I. Lazzaro Spallanzani, Rome, Italy. giuseppina.liuzzi@inmi.it.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Liuzzi
authors.affiliation: Department of Pediatrics and Child Neuropsychiatry, "La Sapienza" University of Rome, Rome, Italy. mario.decurtis@uniroma1.it.
authors.forename: Mario
authors.initials: M
authors.lastname: De Curtis
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D003586:Cytomegalovirus Infections / Q000134:cerebrospinal fluid* / Q000151:congenital*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D000077562:Valganciclovir
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D000077562:Valganciclovir; D015774:Ganciclovir