title: Genotoxicity of single-walled carbon nanotubes: in vitro study on human embryonic fibroblast cells.
abstract: The effects of single-walled carbon nanotubes on the levels of DNA aberrations, chromosome and genome disorders were studied on human embryonic fibroblasts, their karyotype was analyzed by the spectral karyotyping method. The level of DNA aberrations increased after 3-h exposure to the nanotubes. No appreciable increase in the incidence of aberrant metaphases, micronuclei, and chromosome 1, 6, 8, 11, X, and Y aneuploidy after 24- and 48-h incubation with the nanotubes were detected.
authors.affiliation: Medical Genetic Research Center, Russian Academy of Medical Sciences, Moscow, Russia, nikitinava@yandex.ru.
authors.forename: V A
authors.initials: VA
authors.lastname: Nikitina
authors.forename: A I
authors.initials: AI
authors.lastname: Chausheva
authors.forename: I A
authors.initials: IA
authors.lastname: Suetina
authors.forename: L D
authors.initials: LD
authors.lastname: Katosova
authors.forename: D G
authors.initials: DG
authors.lastname: Zheglo
authors.forename: M V
authors.initials: MV
authors.lastname: Mezentseva
authors.forename: V I
authors.initials: VI
authors.lastname: Platonova
authors.forename: Yu A
authors.initials: YA
authors.lastname: Revazova
authors.forename: S I
authors.initials: SI
authors.lastname: Kutsev
mesh_terms: D002460:Cell Line; D004249:DNA Damage / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D009152:Mutagenicity Tests; D037742:Nanotubes, Carbon / Q000633:toxicity*
chemical_list: D037742:Nanotubes, Carbon