title: Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.
abstract: Titanium dioxide (TiO2) nanoparticles are used in many applications. Due to their small size, easy body penetration and toxicological adverse effects have been suspected. Numerous studies have tried to characterize TiO2 translocation after oral, dermal or respiratory exposure. In this study, we focused on TiO2 nanoparticle biodistribution, clearance and toxicological effects after intravenous injection, considering TiO2 translocation in the blood occurs. Using ICP-OES, transmission electron microscopy, and histological methods, we found TiO2 accumulation in liver, lungs and spleen. We estimated TiO2 nanoparticles' half life in the body to about 10 days. Clinical biomarkers were also quantified for 56 days to identify potential toxicological impact on lungs, blood, liver, spleen and kidneys. Results showed absence of toxicological effects after TiO2 intravenous injection at concentrations of 7.7 to 9.4 mg/kg.
authors.affiliation: Institut National de l'Environnement Industriel et des Risques (INERIS), Parc technologique Alata, Verneuil en Halatte, France; Laboratoire Matières et systèmes complexes, UMR7057 CNRS/Université paris Diderot, Paris, France.
authors.forename: Dan
authors.initials: D
authors.lastname: Elgrabli
authors.affiliation: Institut National de l'Environnement Industriel et des Risques (INERIS), Parc technologique Alata, Verneuil en Halatte, France.
authors.forename: Remy
authors.initials: R
authors.lastname: Beaudouin
authors.affiliation: Institut National de l'Environnement Industriel et des Risques (INERIS), Parc technologique Alata, Verneuil en Halatte, France.
authors.forename: Nawel
authors.initials: N
authors.lastname: Jbilou
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire Cadarache (IRSN), Saint Paul les Durance, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Floriani
authors.affiliation: Institut National de l'Environnement Industriel et des Risques (INERIS), Parc technologique Alata, Verneuil en Halatte, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Pery
authors.affiliation: Institut National de l'Environnement Industriel et des Risques (INERIS), Parc technologique Alata, Verneuil en Halatte, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Rogerieux
authors.affiliation: Institut National de l'Environnement Industriel et des Risques (INERIS), Parc technologique Alata, Verneuil en Halatte, France.
authors.forename: Ghislaine
authors.initials: G
authors.lastname: Lacroix
mesh_terms: D000818:Animals; D004577:Electron Probe Microanalysis; D006207:Half-Life; D007275:Injections, Intravenous; D008297:Male; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000633:toxicity / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D008954:Models, Biological; D010316:Particle Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D014025:Titanium / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: C009495:titanium dioxide; D014025:Titanium