title: In vivo and in vitro testing for selenium and selenium compounds bioavailability assessment in foodstuff.
abstract: The assessment of selenium and selenium species bioavailability in foodstuff is of special concern on the context of human nutrition. In vivo (human and animal), and in vitro tests are important approaches for estimating the bioavailability of toxic and essential compounds to humans. An overview on in vivo and in vitro bioavailability assays for releasing selenium and selenium species in foodstuffs is summarized. Se and Se species content in a foodstuff critically influence Se bioavailability and bioactivity to humans and animals. Se bioavailability is affected by foodstuff-matrix major composition and minor components. Foodstuffs processing and/or treatments could enhancement or decrease Se bioavailability. Experimental conditions such as the selection of healthy status of examined people (in in vivo humans approaches), the selection of animal model (in vivo animals approaches), or the selection of GI conditions (in in vitro tests) could determines the results. Thus, international standardized protocol for in vivo and in vitro approaches assessment is mandatory.
authors.affiliation: a Grupo Química Analítica Aplicada (QANAP) , University Institute of Research in Environmental Studies (IUMA) , Department of Analytical Chemistry , Faculty of Sciences, University of A Coruña, Campus de A Coruña, A Coruña , Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Moreda-Piñeiro
authors.affiliation: b Department of Analytical Chemistry , Nutrition and Bromatology, Faculty of Chemistry, University of Santiago de Compostela , Santiago de Compostela , Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Moreda-Piñeiro
authors.affiliation: b Department of Analytical Chemistry , Nutrition and Bromatology, Faculty of Chemistry, University of Santiago de Compostela , Santiago de Compostela , Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Bermejo-Barrera
mesh_terms: D000818:Animals; D001681:Biological Assay; D001682:Biological Availability; D005504:Food Analysis; D006801:Humans; D012643:Selenium / Q000737:chemistry* / Q000493:pharmacokinetics*
chemical_list: D012643:Selenium
keywords: Foodstuff; bioaccessibility; bioactivity; bioavailability; food processing; in vivo and in vitro tests; nutrient content