title: Structured Medication Review to Improve Pharmacotherapy in People with Intellectual Disability and Behavioural Problems.
abstract: BACKGROUND
  Polypharmacy and chronic drug use are common in people with intellectual disability and behavioural problems, although evidence of effectiveness and safety in this population is lacking. This study examined the effects of a structured medication review and aimed to improve pharmacotherapy in inpatients with intellectual disability.
  
  
  METHODS
  In a treatment facility for people with mild to borderline intellectual disability and severe behavioural problems, a structured medication review was performed. Prevalence and type of drug-related problems (DRPs) and of the recommended and executed actions were calculated.
  
  
  RESULTS
  In a total of 55 patients with intellectual disability and behavioural problems, 284 medications were prescribed, in which a DRP was seen in 106 (34%). No indication/unclear indication was the most prevalent DRP (70). Almost 60% of the recommended actions were also executed.
  
  
  CONCLUSIONS
  This high prevalence of DRPs is worrying. The structured medication review is a valuable instrument to optimize pharmacotherapy and to support psychiatrists in adequate prescribing of both psychotropic and somatic drugs.
authors.affiliation: Department of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands.|Altrecht Institute for Mental Health Care, Den Dolder, The Netherlands.
authors.forename: Arlette
authors.initials: A
authors.lastname: Scheifes
authors.affiliation: Department of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands.|Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Toine C G
authors.initials: TC
authors.lastname: Egberts
authors.affiliation: Department of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands.|Licht-Zorg, Psychiatric Care, Maarssen, The Netherlands.
authors.forename: Joost Jan
authors.initials: JJ
authors.lastname: Stolker
authors.affiliation: Altrecht Institute for Mental Health Care, Den Dolder, The Netherlands.|Faculty of Social Sciences, Behavioural Science Institute (BSI), Radboud University Nijmegen, Nijmegen, The Netherlands.
authors.forename: Henk L I
authors.initials: HL
authors.lastname: Nijman
authors.affiliation: Department of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, The Netherlands.|Altrecht Institute for Mental Health Care, Den Dolder, The Netherlands.|Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands.
authors.forename: Eibert R
authors.initials: ER
authors.lastname: Heerdink
mesh_terms: D000293:Adolescent; D000328:Adult; D011307:Drug Prescriptions / Q000592:standards / Q000706:statistics & numerical data*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D019338:Polypharmacy; D000066553:Problem Behavior; D011619:Psychotropic Drugs / Q000008:administration & dosage* / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D011619:Psychotropic Drugs
keywords: drug-related problems; intellectual disability; psychotropic drugs; structured medication review