title: Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase.
abstract: An artificial metathesase results from incorporation of an Hoveyda-Grubbs catalyst bearing an arylsulfonamide anchor within human carbonic anhydrase II. The optimization of the catalytic performance is achieved upon combining both chemical and genetic means. Up to 28 TONs were obtained within four hours under aerobic physiological conditions.
authors.affiliation: Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland. thomas.ward@unibas.ch.
authors.forename: Jingming
authors.initials: J
authors.lastname: Zhao
authors.forename: Anna
authors.initials: A
authors.lastname: Kajetanowicz
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Ward
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D024402:Carbonic Anhydrase II / Q000737:chemistry* / Q000378:metabolism*; D002384:Catalysis; D006801:Humans; D007700:Kinetics; D062105:Molecular Docking Simulation; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D013449:Sulfonamides; D024402:Carbonic Anhydrase II