title: Examining the relationship between obesity and cognitive function: a systematic literature review.
abstract: The increasing prevalence of both obesity and dementia is a significant public health concern, especially as recent research demonstrates a significant relationship between these conditions. However, while there is evidence of an obesity-dementia relationship, the effect of obesity on cognitive function in adults, independent of obesity related comorbidities, remains ambiguous. Furthermore, research is yet to systematically compare evidence for domain specific cognitive deficits in obese adults. A systematic literature review was conducted to assess evidence for domain specific cognitive deficits in obese (BMI>30 kg/m(2)) adults (18-65 years of age) and whether these studies have been able to determine an independent relationship between obesity and cognition over and above relevant comorbidities. Seventeen articles were identified. The literature revealed impairments in obese adults across almost all cognitive domains investigated (e.g. complex attention, verbal and visual memory, decision making). However, numerous methodological limitations were identified which need to be considered in interpretations and conclusions regarding an independent effect. While cognitive impairments in obese adults are evident, as a result of these methodological limitations there is currently insufficient evidence to indicate a reliable and valid independent association between obesity and cognitive impairment in mid-life adults. Further research addressing key methodological limitations (e.g. application of relevant exclusions and control variables, use of appropriate comparison groups and measures) is recommended in order to improve understanding of the relationship between mid-life obesity and cognition. Such research will inform the development of appropriate approaches to identification, prevention and treatment of cognitive decline in obese adults.
authors.affiliation: School of Psychological Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Australia; Centre for Obesity Research and Education, Faculty of Medicine, Nursing & Health Sciences, Monash University, Australia.
authors.forename: Christina
authors.initials: C
authors.lastname: Prickett
authors.affiliation: School of Psychology, Faculty of Arts and Sciences, Australian Catholic University, Australia; Centre for Obesity Research and Education, Faculty of Medicine, Nursing & Health Sciences, Monash University, Australia. Electronic address: leah.brennan@acu.edu.au.
authors.forename: Leah
authors.initials: L
authors.lastname: Brennan
authors.affiliation: School of Psychological Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Australia.
authors.forename: Rene
authors.initials: R
authors.lastname: Stolwyk
mesh_terms: D015992:Body Mass Index; D003071:Cognition; D003072:Cognition Disorders / Q000150:complications*; D006801:Humans; D009765:Obesity / Q000150:complications*
keywords: Body mass index; Cognition; Obesity; Systematic review