title: The value of anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid PET/CT in the diagnosis of recurrent prostate carcinoma: a meta-analysis.
abstract: BACKGROUND
  Anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (anti-3-18F-FACBC) positron emission tomography/computed tomography (PET/CT), 11 C-choline PET/CT, 111In-capromab pendetide, and T2-weighted magnetic resonance imaging (MRI) have been used for detecting prostate carcinoma relapse.
  
  
  OBJECTIVE
  To systematically review and perform a meta-analysis of published data regarding the performance of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma.
  
  
  METHODS
  A comprehensive review of the literature regarding the role of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma was performed. Pooled sensitivity, specificity, and the area under the receiver-operating characteristic of 18F-FACBC PET/CT in the diagnosis of recurrent prostate carcinoma were calculated based on the included studies.
  
  
  RESULTS
  Six studies comprising 251 patients, suspicious of prostate carcinoma recurrence, were included in this meta-analysis. 18F-FACBC PET/CT had an 87% pooled sensitivity, 66% pooled specificity, 0.93 the area under the receiver-operating characteristic curve on a per patient-based analysis in detecting prostate carcinoma recurrence.
  
  
  CONCLUSIONS
  18F-FACBC PET/CT was a non-invasive, metabolic imaging technique in the diagnosis of prostate carcinoma relapse.
authors.affiliation: Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, PR China.
authors.forename: Jingyun
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, PR China.
authors.forename: Leilei
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of Nuclear Medcine, Jin Hua Municipal Central Hospital, Zhe Jiang, PR China 13681221974@163.com.
authors.forename: Guanghua
authors.initials: G
authors.lastname: Wen
authors.affiliation: Department of Nuclear Medicine, Beijing Friendship Hospital of Capital Medical University, Beijing, PR China helenscu@163.com.
authors.forename: Jigang
authors.initials: J
authors.lastname: Yang
mesh_terms: D002264:Carboxylic Acids; D003503:Cyclobutanes; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D011467:Prostate / Q000000981:diagnostic imaging; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D002264:Carboxylic Acids; D003503:Cyclobutanes; C117460:fluciclovine F-18
keywords: PET/CT; Prostate carcinoma; anti-1-amino-3-[18F]fluorocyclobutane-1-carboxylic acid (anti-3-18F-FACBC); recurrence