title: Solitary lung metastasis from intracranial hemangiopericytoma 18 years after initial resection.
abstract: We report a 29-year-old woman who presented with severe headache, nausea and vomiting. A lesion was found in the left petrous ridge and near-total resection was performed. Pathologic examination showed anaplastic hemangiopericytoma (World Health Organization Grade III). Hemangiopericytoma is an uncommon mesenchymal tumor that rarely occurs in an intracranial location. Prior studies have reported a surprisingly high rate of late recurrence and extracranial metastases from intracranial hemangiopericytomas, including metastases to the lungs. Resection was followed by external beam radiation. The tumor recurred intracranially 6 and 13 years later and was treated with gamma knife stereotactic radiosurgery. At year 14, she noticed a lump in her neck and underwent parotidectomy for a mucoepidermoid carcinoma. This new diagnosis prompted a staging chest CT scan which showed a 4mm right upper lobe lung nodule along with additional < 5 mm indeterminate nodules. Over the next 3 years, the nodule increased to 8mm. Wedge biopsy of the lung nodule showed metastatic hemangiopericytoma, histologically similar to the intracranial hemangiopericytoma. Both the primary and the lung metastasis were positive for CD34 and STAT-6. To the best of our knowledge, this is the longest reported interval between a resected intracranial hemangiopericytoma and a histologically confirmed solitary metastasis to the lung.
authors.affiliation: Department of Pathology, Cleveland Clinic, Level 25, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Erika E
authors.initials: EE
authors.lastname: Doxtader
authors.affiliation: Department of Pathology, Cleveland Clinic, Level 25, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Mukhopadhyay
authors.affiliation: Department of Pathology, Cleveland Clinic, Level 25, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: praysor@ccf.org.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Prayson
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D001706:Biopsy; D001932:Brain Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D006393:Hemangiopericytoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D009364:Neoplasm Recurrence, Local; D019635:Neurosurgical Procedures / Q000379:methods*; D010307:Parotid Neoplasms / Q000556:secondary / Q000601:surgery / Q000628:therapy; D016634:Radiosurgery; D050800:STAT6 Transcription Factor / Q000032:analysis; D014057:Tomography, X-Ray Computed
chemical_list: D018952:Antigens, CD34; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human
keywords: Hemangiopericytoma; Lung; Metastasis