title: Development of a risk management tool for prioritizing chemical hazard-food pairs and demonstration for selected mycotoxins.
abstract: We developed a simple tool for ranking chemical hazard-food pairs to assist policy makers and risk managers selecting the hazard-food pairs that deserve more attention and need to be monitored during food safety inspections. The tool is based on the derivation of a "Priority Index" (PI) that results from the ratio of the potency of the hazard and the consumer exposure. The potency corresponds to a toxicity reference value of the hazard, whereas the exposure results from the combination of the concentration of the hazard in the food, and the food consumption. Tool's assumptions and limitations are demonstrated and discussed by ranking a dataset of 13 mycotoxins in 26 food items routinely analyzed in Switzerland. The presented ranking of mycotoxin-food pairs has to be considered as relative due to scarce exposure data availability, and uncertainties in toxicity reference values. However, this representative example allows demonstrating the simplicity and the ability of the PI tool to prioritize chemical hazard-food pairs.
authors.affiliation: ETH Zürich, Department of Health Sciences and Technology, Schmelzbergstrasse 9, 8092 Zürich, Switzerland. Electronic address: alessia.stornetta@hest.ethz.ch.
authors.forename: Alessia
authors.initials: A
authors.lastname: Stornetta
authors.affiliation: Federal Food Safety and Veterinary Office FSVO, 8004 Zürich, Switzerland. Electronic address: barbara.engeli@blv.admin.ch.
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Engeli
authors.affiliation: Federal Food Safety and Veterinary Office FSVO, 8004 Zürich, Switzerland. Electronic address: juerg.zarn@blv.admin.ch.
authors.forename: Jürg A
authors.initials: JA
authors.lastname: Zarn
authors.affiliation: Federal Food Safety and Veterinary Office FSVO, 3097 Liebefeld, Switzerland. Electronic address: gerard.gremaud@blv.admin.ch.
authors.forename: Gérard
authors.initials: G
authors.lastname: Gremaud
authors.affiliation: ETH Zürich, Department of Health Sciences and Technology, Schmelzbergstrasse 9, 8092 Zürich, Switzerland. Electronic address: sturlas@ethz.ch.
authors.forename: Shana J
authors.initials: SJ
authors.lastname: Sturla
mesh_terms: D000818:Animals; D004781:Environmental Exposure; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D009183:Mycotoxins / Q000032:analysis* / Q000145:classification / Q000633:toxicity; D019055:No-Observed-Adverse-Effect Level; D018570:Risk Assessment / Q000379:methods*
chemical_list: D009183:Mycotoxins
keywords: Food safety; Hazard; Mycotoxin; Prioritization; Ranking; Risk management; Tool