title: Hypolipidaemic and anti-oxidative potential of encapsulated herb (Terminalia arjuna) added vanilla chocolate milk in high cholesterol fed rats.
abstract: BACKGROUND
  Atherosclerosis is associated with coronary artery disease and occurs in developing as well as developed countries. In the present investigation, hypolipidaemic and anti-oxidative properties of encapsulated herb (Terminalia arjuna, 1.8%) added vanilla chocolate dairy drink was evaluated in high cholesterol fed Wistar rats for 60 days.
  
  
  RESULTS
  At the end of the experimental period, a significant decrease in the body weight gain by rats receiving the encapsulated herb extract was noted as compared to high cholesterol fed rats. Administration of microencapsulated herb showed a statistically significant decrease in organ weights (epididymal fat and liver). Moreover, a significant decrease in serum lipids such as triglycerides, total cholesterol, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol and atherogenic index was observed with encapsulated Terminalia arjuna extract in high cholesterol fed group. Increases in reduced glutathione and decreases in TBARS levels were also reported in both liver and red blood cell lysates with encapsulated herb supplementation.
  
  
  CONCLUSIONS
  The results demonstrated that the bioactive components (phytosterols, flavanoids, saponins and tannins etc.) which are present in the encapsulated T. arjuna not only withstand the processing conditions but also are effectively released in the intestine and show their effects, such as hypolipidaemic and antioxidant activities, for better treating cardiovascular disease.
authors.affiliation: Dairy Technology Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.
authors.forename: Pravin Digambar
authors.initials: PD
authors.lastname: Sawale
authors.affiliation: Animal Biochemistry Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Pothuraju
authors.affiliation: Dairy Technology Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.
authors.forename: Shaik
authors.initials: S
authors.lastname: Abdul Hussain
authors.affiliation: Dairy Technology Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.
authors.forename: Anuj
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Animal Biochemistry Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.
authors.forename: Suman
authors.initials: S
authors.lastname: Kapila
authors.affiliation: Dairy Technology Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.
authors.forename: Girdhari Ramdas
authors.initials: GR
authors.lastname: Patil
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D059305:Diet, High-Fat; D005419:Flavonoids / Q000008:administration & dosage; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000209:etiology; D000960:Hypolipidemic Agents / Q000008:administration & dosage*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000473:pathology; D008297:Male; D008892:Milk; D009929:Organ Size / Q000187:drug effects; D010840:Phytosterols / Q000008:administration & dosage; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D029766:Terminalia / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D005419:Flavonoids; D000960:Hypolipidemic Agents; D008055:Lipids; D010840:Phytosterols; D010936:Plant Extracts
keywords: Terminalia arjuna; anti-oxidant; cardiovascular disease; high cholesterol diet; hyperlipidaemia