title: Autism Symptomatology in Boys with Fragile X Syndrome: A Cross Sectional Developmental Trajectories Comparison with Nonsyndromic Autism Spectrum Disorder.
abstract: Although males with fragile X syndrome (FXS) are frequently described as demonstrating autism symptomatology, there is much debate regarding whether the behavioral symptoms representing the core domains of autism are the result of the same or different underlying neurological/psychological mechanisms. The present study used a cross-sectional developmental trajectories approach to compare the profiles of autism symptomatology relative to chronological age (CA), nonverbal IQ, and expressive vocabulary ability between individuals with FXS and individuals with nonsyndromic ASD. Results suggest that the onset of autism symptoms and their developmental trajectories in males with FXS differ in important ways as a function of CA, nonverbal cognitive ability, and expressive vocabulary relative to males with nonsyndromic ASD. Theoretical and clinical implications are discussed.
authors.affiliation: MIND Institute, University of California Davis, 2825 50th Street, Room 2101, Sacramento, CA, 95817, USA, ajthurman@ucdavis.edu.
authors.forename: Angela John
authors.initials: AJ
authors.lastname: Thurman
authors.forename: Andrea
authors.initials: A
authors.lastname: McDuffie
authors.forename: Sara T
authors.initials: ST
authors.lastname: Kover
authors.forename: Randi J
authors.initials: RJ
authors.lastname: Hagerman
authors.forename: Leonard
authors.initials: L
authors.lastname: Abbeduto
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000150:complications / Q000175:diagnosis*; D005600:Fragile X Syndrome / Q000150:complications*; D006801:Humans; D007804:Language Development; D008297:Male