title: Role of AGC1/aralar in the metabolic synergies between neuron and glia.
abstract: Brain energetic requirements are elevated due to the high cost of impulse transmission and information storage, and are met mainly by glucose oxidation. The energy needs are closely matched by metabolic regulation, which requires the close cooperation of neurons and astrocytes and involves highly regulated fluxes of metabolites between cells. The metabolism in each type of cell is determined in part by its proteomic profile, which has been regarded as complementary. This review will consider the cellular distribution of the mitochondrial aspartate-glutamate carrier, aralar/AGC1/SLC25A12, and its role in the synergic metabolism between neurons and astrocytes.
authors.affiliation: Centro de Biología Molecular Severo Ochoa CSIC-UAM, CIBER de Enfermedades Raras and Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid 28049, Spain. Electronic address: lcontreras@cbm.csic.es.
authors.forename: Laura
authors.initials: L
authors.lastname: Contreras
mesh_terms: D053674:Aggrecans / Q000502:physiology*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D033681:Mitochondrial Membrane Transport Proteins / Q000502:physiology*; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*
chemical_list: C508319:ACAN protein, human; D053674:Aggrecans; D033681:Mitochondrial Membrane Transport Proteins; C114606:SLC25A12 protein, human
keywords: Aralar; Aspartate; Astrocyte; Glutamine; Metabolism; Neuron