title: Cerebral perfusion and glucose metabolism in Alzheimer's disease and frontotemporal dementia: two sides of the same coin?
abstract: OBJECTIVE
  Alzheimer's disease (AD) and frontotemporal (FTD) dementia can be differentiated using [(18)F]-2-deoxy-2-fluoro-D-glucose (FDG)-PET. Since cerebral blood flow (CBF) is related to glucose metabolism, our aim was to investigate the extent of overlap of abnormalities between AD and FTD.
  
  
  METHODS
  Normalized FDG-PET and arterial spin labelling (ASL-MRI)-derived CBF was measured in 18 AD patients (age, 64 ± 8), 12 FTD patients (age, 61 ± 8), and 10 controls (age, 56 ± 10). Voxel-wise comparisons, region-of-interest (ROI), correlation, and ROC curve analyses were performed.
  
  
  RESULTS
  Voxel-wise comparisons showed decreased CBF and FDG uptake in AD compared with controls and FTD in both precuneus and inferior parietal lobule (IPL). Compared with controls and AD, FTD patients showed both hypometabolism and hypoperfusion in medial prefrontal cortex (mPFC). ASL and FDG were related in precuneus (r = 0.62, p < 0.001), IPL (r = 0.61, p < 0.001), and mPFC across groups (r = 0.74, p < 001). ROC analyses indicated comparable performance of perfusion and metabolism in the precuneus (AUC, 0.72 and 0.74), IPL (0.85 and 0.94) for AD relative to FTD, and in the mPFC in FTD relative to AD (both 0.68).
  
  
  CONCLUSIONS
  Similar patterns of hypoperfusion and hypometabolism were observed in regions typically associated with AD and FTD, suggesting that ASL-MRI provides information comparable to FDG-PET.
  
  
  CONCLUSIONS
  • Similar patterns of hypoperfusion and hypometabolism were observed in patients with dementia. • For both imaging modalities, parietal abnormalities were found in Alzheimer's disease. • For both imaging modalities, prefrontal abnormalities were found in frontotemporal dementia.
authors.affiliation: Department of Radiology & Nuclear Medicine, VU University Medical Centre, Amsterdam, The Netherlands, s.verfaillie@vumc.nl.
authors.forename: Sander C J
authors.initials: SC
authors.lastname: Verfaillie
authors.forename: Sofie M
authors.initials: SM
authors.lastname: Adriaanse
authors.forename: Maja A A
authors.initials: MA
authors.lastname: Binnewijzend
authors.forename: Marije R
authors.initials: MR
authors.lastname: Benedictus
authors.forename: Rik
authors.initials: R
authors.lastname: Ossenkoppele
authors.forename: Mike P
authors.initials: MP
authors.lastname: Wattjes
authors.forename: Yolande A L
authors.initials: YA
authors.lastname: Pijnenburg
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
authors.forename: Adriaan A
authors.initials: AA
authors.lastname: Lammertsma
authors.forename: Joost P A
authors.initials: JP
authors.lastname: Kuijer
authors.forename: Ronald
authors.initials: R
authors.lastname: Boellaard
authors.forename: Philip
authors.initials: P
authors.lastname: Scheltens
authors.forename: Bart N M
authors.initials: BN
authors.lastname: van Berckel
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology*; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D019788:Fluorodeoxyglucose F18; D057180:Frontotemporal Dementia / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012372:ROC Curve; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013113:Spin Labels
chemical_list: D001786:Blood Glucose; D019275:Radiopharmaceuticals; D013113:Spin Labels; D019788:Fluorodeoxyglucose F18