title: The Neuroprotective Mechanism of Low-Frequency rTMS on Nigral Dopaminergic Neurons of Parkinson's Disease Model Mice.
abstract: Background. Parkinson's disease is a neurodegenerative disease in elder people, pathophysiologic basis of which is the severe deficiency of dopamine in the striatum. The purpose of the present study was to evaluate the neuroprotective effect of low-frequency rTMS on Parkinson's disease in model mice. Methods. The effects of low-frequency rTMS on the motor function, cortex excitability, neurochemistry, and neurohistopathology of MPTP-induced Parkinson's disease mice were investigated through behavioral detection, electrophysiologic technique, high performance liquid chromatography-electrochemical detection, immunohistochemical staining, and western blot. Results. Low-frequency rTMS could improve the motor coordination impairment of Parkinson's disease mice: the resting motor threshold significantly decreased in the Parkinson's disease mice; the degeneration of nigral dopaminergic neuron and the expression of tyrosine hydroxylase were significantly improved by low-frequency rTMS; moreover, the expressions of brain derived neurotrophic factor and glial cell line derived neurotrophic factor were also improved by low-frequency rTMS. Conclusions. Low-frequency rTMS had a neuroprotective effect on the nigral dopaminergic neuron which might be due to the improved expressions of brain derived neurotrophic factor and glial cell line-derived neurotrophic factor. The present study provided a theoretical basis for the application of low-frequency rTMS in the clinical treatment and recovery of Parkinson's disease.
authors.affiliation: Fifth Department of Neurology, Cangzhou Central Hospital, No. 16 Xinhua Western Road, Cangzhou, Hebei 061000, China.
authors.forename: Qiaoyun
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Hebei Province Key Laboratory of Brain Aging and Cognitive Neuroscience, No. 16 Xinhua Western Road, Cangzhou, Hebei 061000, China.
authors.forename: Yanyong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Hebei Province Key Laboratory of Brain Aging and Cognitive Neuroscience, No. 16 Xinhua Western Road, Cangzhou, Hebei 061000, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Gu
authors.affiliation: Fifth Department of Neurology, Cangzhou Central Hospital, No. 16 Xinhua Western Road, Cangzhou, Hebei 061000, China.
authors.forename: Rusheng
authors.initials: R
authors.lastname: Shao
authors.affiliation: Fifth Department of Neurology, Cangzhou Central Hospital, No. 16 Xinhua Western Road, Cangzhou, Hebei 061000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Fifth Department of Neurology, Cangzhou Central Hospital, No. 16 Xinhua Western Road, Cangzhou, Hebei 061000, China.
authors.forename: Xiqi
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurology, Cangzhou Central Hospital, No. 16 Xinhua Western Road, Cangzhou, Hebei 061000, China.
authors.forename: Zhanqiang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Hebei Province Key Laboratory of Brain Aging and Cognitive Neuroscience, No. 16 Xinhua Western Road, Cangzhou, Hebei 061000, China.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Wang