title: [A Japanese case of neuroborreliosis with papillitis].
abstract: A 53-year-old Japanese female developed a fever about two months after a tick bite. She also exhibited blurred vision, central scotoma in the left eye, left facial paresis and mild ataxia. A fundus examination revealed left disc swelling in the left eye. An ophthalmological examination showed decreased visual acuity with central scotoma in the left eye. We suspected neuroborreliosis because of the presence of pleocytosis and an elevated level of IL-6 in the cerebrospinal fluid (CSF), in addition to the characteristic neurological findings. She was positive for serum IgG antibodies against Borrelia by a Western blot of her serum. Therefore, we diagnosed her to have neuroborreliosis with papillitis. After the combined administration of antibiotics and steroids, her symptoms gradually improved, but not all of her eye manifestations resolved. Although ocular involvement is rare in neuroborreliosis, this case highlights the fact that neuroborreliosis shoud be considered as a differential diagnosis for patients presenting with papillitis. The diagnosis of neuroborreliosis is important since improvement of the visual acuity is possible with specific antibiotheraphy. In cases with papillitis of unknown etiology, it might be better to consider the possibility of neuroborreliosis should be considered when there are signs of Lyme borreliosis, such as facial nerve palsy, arthritis or radiculoneuritis.
authors.affiliation: Department of Neurology, National Hospital Organization Beppu Medical Center.
authors.forename: Junpei
authors.initials: J
authors.lastname: Kouge
authors.forename: Shotaro
authors.initials: S
authors.lastname: Hayashida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Imaki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Mitsuo
mesh_terms: D044466:Asian People; D015415:Biomarkers / Q000097:blood; D025065:Borrelia burgdorferi / Q000276:immunology; D002443:Ceftriaxone / Q000008:administration & dosage; D004318:Doxycycline / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D020852:Lyme Neuroborreliosis; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D010211:Papilledema / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D011239:Prednisolone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug; D064927:Tick Bites / Q000150:complications; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D007074:Immunoglobulin G; D002443:Ceftriaxone; D011239:Prednisolone; D004318:Doxycycline; D008775:Methylprednisolone