title: Association of VEGF genetic polymorphisms with recurrent spontaneous abortion risk: a systematic review and meta-analysis.
abstract: BACKGROUND
  Studies of the associations between the genetic polymorphisms of the vascular endothelial growth factor (VEGF) gene and recurrent spontaneous abortion (RSA) have revealed conflicting results. The present meta-analysis was performed to provide a more precise estimation of these relationships and to explore potential sources of heterogeneity that may have influenced the reported disparities.
  
  
  METHODS
  An extensive literature search for relevant studies was conducted on PubMed, Embase, and The Cochrane Library through June 6, 2014. Crude odds ratio (OR) with 95% confidence intervals were calculated.
  
  
  RESULTS
  10 case-control studies including 1,832 RSA patients and 2,271 healthy controls were identified. Meta-analysis indicated that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms in the VEGF gene correlated with elevated RSA risk. The rs1570360 variant was statistically significantly relevant to RSA risk among non-Asian populations. Interestingly, the rs3025039 variant was statistically significantly relevant to RSA risk among Asian populations.
  
  
  CONCLUSIONS
  The current meta-analysis indicates that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms increase RSA susceptibility. Moreover, rs1570360 and rs3025039 polymorphisms may play various roles in RSA susceptibility in various geographic groups.
authors.affiliation: Department of Gynecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, 252000, China; Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250021, China; The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, 250021, China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, 252000, China.
authors.forename: Chigang
authors.initials: C
authors.lastname: Du
authors.affiliation: Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200127, China.
authors.forename: Huihui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Gynecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, 252000, China; Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250021, China; The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, 250021, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Gynecology and Obstetrics, Tianjin third central hospital, Tianjin, 300170, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yan
authors.affiliation: Department of Gynecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, 252000, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Peng
authors.affiliation: Department of Hematology, Liaocheng People's Hospital, Liaocheng, 252000, China.
authors.forename: Guangyao
authors.initials: G
authors.lastname: Li
authors.affiliation: Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250021, China; The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, 250021, China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200127, China.
authors.forename: Zi-Jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D017594:Publication Bias; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A