title: A newborn with teratogenic effect of imatinib mesylate: a very rare case report.
abstract: OBJECTIVE
  To report a case of teratogenic effect of imatinib mesylate (IM) in a newborn, whose mother was suffering from chronic myelogenous leukemia and was treated with IM for 4 years, including during her pregnancy.
  
  
  METHODS
  The newborn was diagnosed with microtia of the right ear, preauricular tag on the left side, absence of right depressor angular oris muscle, and imperforate anus. Infantogram showed dextrocardia, hemivertebrae in the thoracic region and cervical spina bifida occulta. The newborn was operated on for the imperforate anus and was discharged in good condition.
  
  
  CONCLUSIONS
  This case revealed that IM is not safe for the fetus and leads to teratogenicity. Hence, we recommend that pregnant women should not be treated with IM.
authors.affiliation: J.C.D. Dental College, Sirsa, India.
authors.forename: Namita
authors.initials: N
authors.lastname: Jain
authors.forename: Deepak
authors.initials: D
authors.lastname: Sharma
authors.forename: Renu
authors.initials: R
authors.lastname: Agrawal
authors.forename: Adeesh
authors.initials: A
authors.lastname: Jain
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000503:physiopathology*; D000970:Antineoplastic Agents / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate / Q000627:therapeutic use / Q000633:toxicity*; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy; D008297:Male; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D000068877:Imatinib Mesylate