title: Evaluation of regional cerebral blood flow in Alzheimer's disease patients with subclinical hypothyroidism.
abstract: BACKGROUND
  This study examined regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients with and without subclinical hypothyroidism (SCH).
  
  
  METHODS
  Eleven AD patients with SCH and 141 AD patients without SCH underwent brain perfusion single photon emission computed tomography (SPECT). The SPECT data were analyzed by statistical parametric mapping (SPM8) and FineSRT.
  
  
  RESULTS
  AD patients with SCH showed a significantly decreased rCBF mainly in the temporal lobe and thalamus, whereas those without SCH showed a significantly decreased rCBF in the parietotemporal lobe and cingulate gyrus as well as the frontal lobe.
  
  
  CONCLUSIONS
  Our findings suggest that SCH may affect cerebral perfusion in regions associated with the memory function.
authors.affiliation: Department of Neurology, Faculty of Medicine, Oita University, Oita, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Haji
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kimura
authors.forename: Takuya
authors.initials: T
authors.lastname: Hanaoka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Aso
authors.forename: Makoto
authors.initials: M
authors.lastname: Takemaru
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Hirano
authors.forename: Etsuro
authors.initials: E
authors.lastname: Matsubara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging; D001931:Brain Mapping / Q000379:methods; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications*; D008297:Male; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods