title: The clinical significance of preoperative plasma fibrinogen level and platelet count in resectable esophageal squamous cell carcinoma.
abstract: BACKGROUND
  Patients with malignant disease frequently present with activated coagulation pathways, which are potentially associated with tumor progression and prognosis. The aims of the study were to investigate the clinical significance of preoperative plasma fibrinogen level and platelet count in esophageal squamous cell carcinoma (ESCC) treated by curative surgery.
  
  
  METHODS
  A total of 119 patients with ESCC treated by curative surgery in Qilu Hospital of Shandong University were included in the study.
  
  
  RESULTS
  The preoperative plasma fibrinogen levels in the patients with ESCC ranged from 2.2 to 6.91 g/L (mean ± SD, 3.85 ± 0.95 g/L). The incidence of hyperfibrinogenemia was 43.7% (52/119, cut-off value 4.0 g/L). Hyperfibrinogenemia was found to be positively correlated with increased tumor length (P = 0.027), increased depth of invasion (P = 0.013), advanced pathological stages (P = 0.011), and disease recurrence (P = 0.026). The platelet counts ranged from 78 × 10(9)/L to 936 × 10(9)/L (mean ± SD, 254.51 ± 89.26 × 10(9)/L). The incidence of thrombocytosis was 20.2% (24/119, cut-off value 300 × 10(9)/L). Thrombocytosis was more frequently seen in male gender (P = 0.029) and non-smokers (P = 0.008). Plasma fibrinogen levels were significantly correlated with platelet counts (r = 0.018, P = 0.048). Hyperfibrinogenemia was significantly associated with poor disease-free (P = 0.009, hazard ratio (HR) = 1.784, 95% confidence interval (CI) = 1.153 to 2.761) and overall (P = 0.003, HR = 1.992, 95% CI = 1.259 to 3.152) survivals in univariate analysis, but not an independent prognostic indicator in multivariate analysis. Thrombocytosis was not significantly associated with disease-free (P = 0.765, HR = 0.918, 95% CI = 0.524 to 1.608) or overall (P = 0.809, HR = 1.072, 95% CI = 0.618 to 1.891) survivals in univariate analysis.
  
  
  CONCLUSIONS
  The study suggested that hyperfibrinogenemia is a valuable predictor for disease progression in ESCC. Anticoagulation therapy might be considered to control cancer progression in future studies.
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, People's Republic of China. qlwjb2008@163.com.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, People's Republic of China. liuhongy67@sina.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Departments of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwu Weiqi Road, Jinan, People's Republic of China. shaona786@163.com.
authors.forename: Na
authors.initials: N
authors.lastname: Shao
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, People's Republic of China. tan-bx@163.com.
authors.forename: Bingxu
authors.initials: B
authors.lastname: Tan
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, People's Republic of China. sqxsdu@163.com.
authors.forename: Qingxu
authors.initials: Q
authors.lastname: Song
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, People's Republic of China. jiayibin2011@126.com.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Radiation, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, People's Republic of China. qlcyf1965@163.com.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D010976:Platelet Count; D011300:Preoperative Care; D011379:Prognosis; D015996:Survival Rate
chemical_list: D005340:Fibrinogen