title: Natural environments, ancestral diets, and microbial ecology: is there a modern "paleo-deficit disorder"? Part II.
abstract: Famed microbiologist René J. Dubos (1901-1982) was an early pioneer in the developmental origins of health and disease (DOHaD) construct. In the 1960s, he conducted groundbreaking research concerning the ways in which early-life experience with nutrition, microbiota, stress, and other environmental variables could influence later-life health outcomes. He recognized the co-evolutionary relationship between microbiota and the human host. Almost 2 decades before the hygiene hypothesis, he suggested that children in developed nations were becoming too sanitized (vs. our ancestral past) and that scientists should determine whether the childhood environment should be "dirtied up in a controlled manner." He also argued that oft-celebrated growth chart increases via changes in the global food supply and dietary patterns should not be equated to quality of life and mental health. Here in the second part of our review, we reflect the words of Dubos off contemporary research findings in the areas of diet, the gut-brain-axis (microbiota and anxiety and depression) and microbial ecology. Finally, we argue, as Dubos did 40 years ago, that researchers should more closely examine the relevancy of silo-sequestered, reductionist findings in the larger picture of human quality of life. In the context of global climate change and the epidemiological transition, an allergy epidemic and psychosocial stress, our review suggests that discussions of natural environments, urbanization, biodiversity, microbiota, nutrition, and mental health, are often one in the same.
authors.affiliation: CAMNR, 23679 Calabasas Road Suite 542, Calabasas, CA, 91302, USA. aclnd@cfs-fm.org.
authors.forename: Alan C
authors.initials: AC
authors.lastname: Logan
authors.affiliation: Department of Psychiatry, Faculty of Medicine, University of Toronto, 250 College Street, 8th floor, Toronto, ON, M5T 1R8, Canada. mkatzman@startclinic.ca.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Katzman
authors.affiliation: Section of Psychiatry, Department of Medicine, University of Valencia Medical School, Avda. Blasco Ibáñez, 15. E46010, Valencia, Spain. Vicente.Balanza@uv.es.
authors.forename: Vicent
authors.initials: V
authors.lastname: Balanzá-Martínez
mesh_terms: D000203:Activities of Daily Living; D000885:Anthropology, Physical; D066046:Diet, Paleolithic; D004463:Ecology; D005247:Feeding Behavior; D006801:Humans; D064307:Microbiota; D019368:Nature; D052756:Nutritional Sciences; D019936:Probiotics; D011788:Quality of Life; D013315:Stress, Psychological