title: Association between chemotactic chemokine ligand 5 -403G/A polymorphism and risk of human immunodeficiency virus-1 infection: a meta-analysis.
abstract: BACKGROUND
  The association between chemotactic chemokine ligand 5 (CCL5) -403G/A gene polymorphism and human immunodeficiency virus-1 (HIV-1) infection has been illustrated among several case-control studies, but the conclusions are still inconsistent. Here we performed a meta-analysis to estimate the association.
  
  
  METHODS
  The published studies based upon the association between CCL5 -403G/A polymorphism and HIV-1 infection were retrieved from PubMed, Embase, and China National Knowledge Infrastructure database. Quantitative synthesis, including pooled odds ratios (ORs) and 95% confidence intervals (CIs), was performed for all genetic models.
  
  
  RESULTS
  A total of ten studies consisting of 5,127 subjects were included for this meta-analysis. There was no association found between -403G/A polymorphism and HIV-1 infection in the overall analysis under any genetic models. Further stratified by ethnicity, our analysis showed that -403A/A polymorphism significantly decreased the susceptibility to HIV-1 infection in three models: the dominant model (AA+AG vs GG: OR =0.44, 95% CI =0.21-0.94) among Africans, the homozygous model (AA vs GG: OR =0.62, 95% CI =0.242-0.90), and the recessive model (AA vs GG+AG: OR =0.62, 95% CI =0.45-0.93) among Asians.
  
  
  CONCLUSIONS
  We found that only Asians and Africans with CCL5 -403A/A polymorphism could be resistant to HIV-1 infection. However, further studies should be performed to evaluate this association on ethnic basis against control groups consisting of individuals who have once been exposed to HIV-1 but are seronegative.
authors.affiliation: Department of Infectious Disease, the First Affiliated Hospital of Nanchang University, Nanchang, People's Republic of China.
authors.forename: Jianglong
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Pediatrics, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China.
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Public Health, Center for Disease Control and Prevention, Jiangxi Province, Nanchang, People's Republic of China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Public Health, Center for Disease Control and Prevention, Jiangxi Province, Nanchang, People's Republic of China.
authors.forename: Tinli
authors.initials: T
authors.lastname: Jin
authors.affiliation: Department of Public Health, Center for Disease Control and Prevention, Jiangxi Province, Nanchang, People's Republic of China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Liao
authors.affiliation: Department of Public Health, Center for Disease Control and Prevention, Jiangxi Province, Nanchang, People's Republic of China.
authors.forename: Guoliang
authors.initials: G
authors.lastname: Hu
keywords: CCL5; HIV-1; meta-analysis; polymorphism; susceptibility