title: PVT1: a rising star among oncogenic long noncoding RNAs.
abstract: It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function. However, while the functional characterization of short non-coding RNAs has been reaching maturity, there is still a paucity of well characterized long noncoding RNAs, even though large studies in recent years are rapidly increasing the number of annotated ones. The long noncoding RNA PVT1 is encoded by a gene that has been long known since it resides in the well-known cancer risk region 8q24. However, a couple of accidental concurrent conditions have slowed down the study of this gene, that is, a preconception on the primacy of the protein-coding over noncoding RNAs and the prevalent interest in its neighbor MYC oncogene. Recent studies have brought PVT1 under the spotlight suggesting interesting models of functioning, such as competing endogenous RNA activity and regulation of protein stability of important oncogenes, primarily of the MYC oncogene. Despite some advancements in modelling the PVT1 role in cancer, there are many questions that remain unanswered concerning the precise molecular mechanisms underlying its functioning.
authors.affiliation: Institute for Computing Applications "Mauro Picone", National Research Council, Via dei Taurini 19, 00185 Rome, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Colombo
authors.affiliation: Department of Computer, Control and Management Engineering, Sapienza University of Rome, Via Ariosto 25, 00185 Rome, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Farina
authors.affiliation: Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Macino
authors.affiliation: Institute for System Analysis and Computer Science "Antonio Ruberti", National Research Council, Via dei Taurini 19, 00185 Rome, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Paci
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D056915:DNA Copy Number Variations; D004195:Disease Models, Animal; D005784:Gene Amplification; D018628:Gene Dosage; D015972:Gene Expression Regulation, Neoplastic; D023281:Genomics; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: C521123:PVT1 long-non-coding RNA, human; D062085:RNA, Long Noncoding