title: Cutaneous reactions to vaccinations.
abstract: Vaccinations are important for infectious disease prevention; however, there are adverse effects of vaccines, many of which are cutaneous. Some of these reactions are due to nonspecific inflammation and irritation at the injection site, whereas other reactions are directly related to the live attenuated virus. Rarely, vaccinations have been associated with generalized hypersensitivity reactions, such as erythema multiforme, Stevens-Johnson syndrome, urticaria, acute generalized exanthematous pustulosis, and drug hypersensitivity syndrome. The onset of certain inflammatory dermatologic conditions, such as lichen planus, granuloma annulare, and pemphigoid, were reported to occur shortly after vaccine administration. Allergic contact dermatitis can develop at the injection site, typically due to adjuvant ingredients in the vaccine, such as thimerosal and aluminum. Vaccinations are important to promote development of both individual and herd immunity. Although most vaccinations are considered relatively safe, there may be adverse effects associated with any vaccine. Cutaneous manifestations make up a large portion of the types of reactions associated with vaccines. There are many different reasons for the development of a cutaneous reaction to a vaccination. Some are directly related to the injection of a live attenuated virus, such as varicella or vaccinia (for immunity to smallpox), whereas others cause more nonspecific erythema and swelling at the injection site, as a result of local inflammation or irritation. Vaccinations have also been associated in rare reports with generalized hypersensitivity reactions, such as erythema multiforme, Stevens-Johnson syndrome, urticaria, acute generalized exanthematous pustulosis, and drug hypersensitivity syndrome. There have been case reports associating the administration of a vaccine with the new onset of a dermatologic condition, such as lichen planus, granuloma annulare, and Sweet syndrome. Finally, allergic contact dermatitis can develop at the injection site, typically due to adjuvant ingredients in the vaccine, such as thimerosal and aluminum.
authors.affiliation: Department of Medicine, Section of Dermatology, University of Chicago, Pritzker School of Medicine, 5841 S. Maryland Ave MC 5067, Chicago, IL 60637. Electronic address: adena.rosenblatt@uchospitals.edu.
authors.forename: Adena E
authors.initials: AE
authors.lastname: Rosenblatt
authors.affiliation: Department of Medicine, Section of Dermatology, University of Chicago, Pritzker School of Medicine, 5841 S. Maryland Ave MC 5067, Chicago, IL 60637; Department of Pediatrics, University of Chicago Pritzker School of Medicine, 5841 S. Maryland Ave MC, 5067 Chicago, IL 60637.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Stein
mesh_terms: D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D012900:Smallpox Vaccine / Q000009:adverse effects; D014612:Vaccines / Q000009:adverse effects*
chemical_list: D012900:Smallpox Vaccine; D014612:Vaccines