title: [Calpains and their endo- and exogenous regulators in various neurodegeneration models].
abstract: On the basis of experimental series with murine models there was obtained the evidence on calcium-dependent protease activity changes in rat brain at induced neurodegeneration. The properties of the proteolytic and regulatory components of calpain system under the effect of neurotoxic stimuli--amyloid beta-peptide or glutamate--were characterized; the basic endogenous regulatory mechanisms of calcium-dependent proteolysis modulation were determined as well. Neuroprotective properties of exogenous calpain regulators differing in the mechanisms of action (sex steroids, calcium regulators) were tested on studied neurodegeneration models.
authors.forename: L A
authors.initials: LA
authors.lastname: Lysenko
authors.forename: N P
authors.initials: NP
authors.lastname: Kantserova
authors.forename: N L
authors.initials: NL
authors.lastname: Rendakov
authors.forename: N N
authors.initials: NN
authors.lastname: Nemova
mesh_terms: D016229:Amyloid beta-Peptides / Q000008:administration & dosage; D000818:Animals; D001931:Brain Mapping; D002118:Calcium / Q000378:metabolism; D002154:Calpain / Q000096:biosynthesis* / Q000378:metabolism; D018698:Glutamic Acid / Q000008:administration & dosage; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D023421:Models, Animal; D009410:Nerve Degeneration / Q000378:metabolism* / Q000473:pathology; D051381:Rats
chemical_list: D016229:Amyloid beta-Peptides; D012739:Gonadal Steroid Hormones; D018698:Glutamic Acid; D002154:Calpain; D002118:Calcium