title: Leishmaniasis and its relevance to UK Armed Forces.
abstract: Leishmaniasis is an infectious disease caused by Leishmania protozoa, transmitted by the bite of phlebotomine sandflies. It causes a spectrum of clinical syndromes, of which the most common are cutaneous and visceral leishmaniasis. Clinical presentation is highly variable and is dependent on multiple factors, such as Leishmania species and patient characteristics (including immune competence). The relationship between these variables is poorly understood, and there is no single, evidence-based treatment for the disease. Currently management focuses on identification of the species, but this requires specialist tests which are often unavailable, particularly on military operations. Leishmaniasis is of particular relevance to military medical personnel as it is endemic in many tropical and sub-tropical regions of the world, including Belize, Iraq and Afghanistan where UK Armed Forces may be deployed. It can present a potentially serious threat to military personnel deployed in endemic areas due to the possibility of long-term sequelae of infection.
authors.forename: H C
authors.initials: HC
authors.lastname: Preedy
authors.forename: M S
authors.initials: MS
authors.lastname: Bailey
mesh_terms: D000967:Antimony Sodium Gluconate / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D019353:Endemic Diseases; D006801:Humans; D057148:Insecticide-Treated Bednets; D007896:Leishmaniasis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D008887:Military Medicine; D009784:Occupational Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D006113:United Kingdom
chemical_list: D000981:Antiprotozoal Agents; D000967:Antimony Sodium Gluconate