title: Synthetic high-density lipoprotein-like nanoparticles as cancer therapy.
abstract: High-density lipoproteins (HDL) are diverse natural nanoparticles that carry cholesterol and are best known for the role that they play in cardiovascular disease. However, due to their unique targeting capabilities, diverse molecular cargo, and natural functions beyond cholesterol transport, it is becoming increasingly appreciated that HDLs are critical to cancer development and progression. Accordingly, this chapter highlights ongoing research focused on the connections between HDL and cancer in order to design new drugs and targeted drug delivery vehicles. Research is focused on synthesizing biomimetic HDL-like nanoparticles (NP) that can be loaded with diverse therapeutic cargo (e.g., chemotherapies, nucleic acids, proteins) and specifically targeted to cancer cells. Beyond drug delivery, new data is emerging that HDL-like NPs may be therapeutically active in certain tumor types, for example, B cell lymphoma. Overall, HDL-like NPs are becoming increasingly appreciated as targeted, biocompatible, and efficient therapies for cancer, and may soon become indispensable agents in the cancer therapeutic armamentarium.
authors.affiliation: Feinberg School of Medicine, Department of Urology, Northwestern University, Tarry 16-703, 303 E. Chicago Ave, Chicago, IL, 60611, USA.
authors.forename: Kaylin M
authors.initials: KM
authors.lastname: McMahon
authors.forename: Linda
authors.initials: L
authors.lastname: Foit
authors.forename: Nicholas L
authors.initials: NL
authors.lastname: Angeloni
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Giles
authors.forename: Leo I
authors.initials: LI
authors.lastname: Gordon
authors.forename: C Shad
authors.initials: CS
authors.lastname: Thaxton
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008075:Lipoproteins, HDL / Q000737:chemistry / Q000627:therapeutic use*; D058726:Nanoconjugates / Q000627:therapeutic use*; D050997:Nanomedicine / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D008075:Lipoproteins, HDL; D058726:Nanoconjugates