title: Potential role for targeted therapy in muscle-invasive bladder cancer: lessons from the cancer genome atlas and beyond.
abstract: The Cancer Genome Atlas project has identified and confirmed several important molecular alterations that form the basis for tumorigenesis and disease progression in muscle-invasive bladder cancer. Profiling studies also have reported on validated biomarker panels that predict prognosis and may be used to identify patients who require more aggressive therapy. This article describes the major molecular alterations in muscle-invasive urothelial carcinoma, and how several of these are being investigated as targets for novel therapeutics. It also highlights studies that identify biomarkers for platinum sensitivity, and efforts to integrate targeted therapeutics and companion theranostics for personalized treatment of muscle-invasive bladder cancer.
authors.affiliation: Department of Pathology and Center for Personalized Medicine, University of Southern California, 4650 Sunset Boulevard, SRT 1014, MS 103, Los Angeles, CA 90027, USA.
authors.forename: Anirban P
authors.initials: AP
authors.lastname: Mitra
authors.affiliation: Translational Biology and Molecular Medicine Program, Scott Department of Urology, Dan L. Duncan Cancer Center, Baylor College of Medicine Medical Center, 7200 Cambridge, MC BCM380, A10.107, Houston, TX 77030, USA. Electronic address: slerner@bcm.edu.
authors.forename: Seth P
authors.initials: SP
authors.lastname: Lerner
mesh_terms: D001271:Atlases as Topic; D015894:Genome, Human; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*
chemical_list: D007155:Immunologic Factors; D047428:Protein Kinase Inhibitors
keywords: Clinical trials; Mutation analysis; Prognosis; Targeted therapy; Urothelial carcinoma; Whole-genome sequencing