title: Subversion of the B-cell compartment during parasitic, bacterial, and viral infections.
abstract: Recent studies on HIV infection have identified new human B-cell subsets with a potentially important impact on anti-viral immunity. Current work highlights the occurrence of similar B-cell alterations in other viral, bacterial, and parasitic infections, suggesting that common strategies have been developed by pathogens to counteract protective immunity. For this review, we have selected key examples of human infections for which B-cell alterations have been described, to highlight the similarities and differences in the immune responses to a variety of pathogens. We believe that further comparisons between these models will lead to critical progress in the understanding of B-cell mechanisms and will open new target avenues for therapeutic interventions.
authors.affiliation: INSERM u1016, Cochin Institute, Department of Infection, Immunity and Inflammation, 27 rue du Faubourg St-Jacques, Roussy Bldg., Paris, 75014, France. gwenoline.borhis@inserm.fr.|CNRS, Paris, UMR8104, France. gwenoline.borhis@inserm.fr.|Université Paris Descartes, Sorbonne Paris Cité, Paris, 75014, France. gwenoline.borhis@inserm.fr.
authors.forename: Gwenoline
authors.initials: G
authors.lastname: Borhis
authors.affiliation: INSERM u1016, Cochin Institute, Department of Infection, Immunity and Inflammation, 27 rue du Faubourg St-Jacques, Roussy Bldg., Paris, 75014, France. yolande.richard@inserm.fr.|CNRS, Paris, UMR8104, France. yolande.richard@inserm.fr.|Université Paris Descartes, Sorbonne Paris Cité, Paris, 75014, France. yolande.richard@inserm.fr.
authors.forename: Yolande
authors.initials: Y
authors.lastname: Richard
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D001402:B-Lymphocytes / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology / Q000821:virology; D001691:Biological Therapy; D006790:Host-Parasite Interactions; D006801:Humans; D057131:Immune Evasion; D007239:Infections / Q000276:immunology* / Q000628:therapy