title: [Expression of helicase DDX41 in human dental pulp tissues and cells].
abstract: OBJECTIVE
  To detect the expression of D-E-A-D-box polypeptide 41 (DDX41) in human dental pulp tissues and cells.
  
  
  METHODS
  The mRNA and protein expressions of DDX41 in human dental pulp cells were detected by RT-PCR and immunocytochemistry, and the expression of DDX41 in human dental pulp tissues was investigated by immunohistochemistry.
  
  
  RESULTS
  Strong expressions of DDX41 mRNA and protein were detected in dental pulp cells. In dental pulp tissues, DDX41 was expressed in the cytoplasm and nucleus of odontoblasts.
  
  
  CONCLUSIONS
  DDX41/STING-dependent TBK1-IRF3-IFN-β signaling pathway may play a role in innate immune responses of the dental pulp to caries and pulpitis.
authors.affiliation: Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail: yxj_den@163.com.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Hou
authors.forename: Xin-Zhu
authors.initials: XZ
authors.lastname: Li
authors.forename: Jiao
authors.initials: J
authors.lastname: Hu
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured; D003593:Cytoplasm / Q000378:metabolism; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D003782:Dental Pulp / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009804:Odontoblasts / Q000378:metabolism*; D012333:RNA, Messenger; D015398:Signal Transduction
chemical_list: D012333:RNA, Messenger; C501226:DDX41 protein, human; D053487:DEAD-box RNA Helicases