title: First report of linezolid dependence in methicillin-resistant Staphylococcus aureus.
abstract: Linezolid is used to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA). We describe the first report of linezolid dependence in MRSA. The strain was isolated from a respiratory sample of a cystic fibrosis patient, and it showed a thymidine-dependent small-colony variant phenotype. The effect was not related to any known mechanisms implicated in S. aureus resistance to linezolid. The clinical significance of this phenomenon needs further investigation.
authors.affiliation: Unidad de Enfermedades Infecciosas y Microbiología Clínica, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Seville, Spain. Electronic address: inlopezh@us.es.
authors.forename: I
authors.initials: I
authors.lastname: López-Hernández
authors.affiliation: Unidad de Enfermedades Infecciosas y Microbiología Clínica, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Seville, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Delgado Valverde
authors.affiliation: Unidad de Enfermedades Infecciosas y Microbiología Clínica, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Seville, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Batista Díaz
authors.affiliation: Unidad de Enfermedades Infecciosas y Microbiología Clínica, Hospitales Universitarios Virgen Macarena y Virgen del Rocío, Seville, Spain; Departamento de Microbiología, Universidad de Sevilla, Sevilla, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Pascual
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000150:complications; D006801:Humans; D000069349:Linezolid / Q000378:metabolism*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development* / Q000302:isolation & purification / Q000378:metabolism; D013203:Staphylococcal Infections / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000069349:Linezolid
keywords: Cystic fibrosis; MRSA; dependence; linezolid; small-colony variant