title: CCL19/CCL21-Dependent Chemotaxis of Dendritic Cells in Healthy Individuals and Patients with Brain Tumors.
abstract: We compared migration activities of IFN-α- and IL-4-induced dendritic cells (IFN-DC and IL4-DC) generated from blood monocytes of healthy donors and analyzed migration activity of IFN-DC from patients with brain tumors. In the presence of CCL19 chemokine, donor IFN-DC exhibited higher migration activity than IL4-DC, the expression of chemokine CCR7-receptor being similar in the two cell types. IFN-DC of patients with malignant gliomas were characterized by low chemotaxis in response to CCL19 and CCL21 stimulation despite a trend to higher expression of CCR7 in comparison with donor IFN-DC.
authors.affiliation: Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, ct_lab@mail.ru.
authors.forename: T V
authors.initials: TV
authors.lastname: Tyrinova
authors.forename: O Yu
authors.initials: OY
authors.lastname: Leplina
authors.forename: M A
authors.initials: MA
authors.lastname: Tikhonova
authors.forename: S V
authors.initials: SV
authors.lastname: Mishinov
authors.forename: V V
authors.initials: VV
authors.lastname: Stupak
authors.forename: A A
authors.initials: AA
authors.lastname: Ostanin
authors.forename: E R
authors.initials: ER
authors.lastname: Chernykh
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism*; D002478:Cells, Cultured; D054415:Chemokine CCL19 / Q000235:genetics / Q000378:metabolism*; D054421:Chemokine CCL21 / Q000235:genetics / Q000378:metabolism*; D002633:Chemotaxis / Q000235:genetics / Q000502:physiology; D003713:Dendritic Cells / Q000378:metabolism*; D005260:Female; D005910:Glioma / Q000378:metabolism; D006801:Humans; D008297:Male; D054400:Receptors, CCR7 / Q000378:metabolism
chemical_list: C515370:CCR7 protein, human; D054415:Chemokine CCL19; D054421:Chemokine CCL21; D054400:Receptors, CCR7