title: Trivalent Chromium has no Effect on Delaying Azoxymethane-Induced Colorectal Cancer in FVB/NJ Mice.
abstract: As Cr(III) compounds have been shown to increase insulin sensitivity and decrease plasma cholesterol and triglycerides in rodent models of diabetes and insulin resistance and as colorectal cancer risk has been associated with insulin resistance and diabetes, the effects of the Cr(III) compound Cr3 ([Cr3O(O2CCH2CH3)6(H2O)3](+)) were investigated in male and female FVB/NJ mice with azoxymethane-induced colorectal cancer. In contrast to a previous study on the effects of Cr3 on 1,2-dimethylhydrazine-induced colorectal cancer in Sprague Dawley rats, no effects of Cr3 at daily doses of 1 and 10 mg Cr/kg body mass were observed, leaving in question whether administration of Cr(III) compounds can delay or prevent the onset of colorectal cancer.
authors.affiliation: Department of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
authors.forename: Pandora E
authors.initials: PE
authors.lastname: White
authors.affiliation: Department of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
authors.forename: Ge
authors.initials: G
authors.lastname: Deng
authors.affiliation: Department of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
authors.forename: M Kaitlyn
authors.initials: MK
authors.lastname: Kuykendall
authors.affiliation: Department of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
authors.forename: Abbey M
authors.initials: AM
authors.lastname: Tadros
authors.affiliation: Department of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
authors.forename: Samantha L
authors.initials: SL
authors.lastname: Dyroff
authors.affiliation: Department of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Honan
authors.affiliation: Department of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA.
authors.forename: Preshus M
authors.initials: PM
authors.lastname: Robertson
authors.affiliation: Department of Chemistry, The University of Alabama, Tuscaloosa, AL, 35487-0336, USA. jvincent@bama.ua.edu.
authors.forename: John B
authors.initials: JB
authors.lastname: Vincent
authors.affiliation: Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL, 35487-0344, USA.
authors.forename: Jane F
authors.initials: JF
authors.lastname: Rasco
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001397:Azoxymethane / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D017608:Chromium Compounds / Q000494:pharmacology*; D015179:Colorectal Neoplasms / Q000139:chemically induced* / Q000517:prevention & control*; D005260:Female; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D016588:Anticarcinogenic Agents; D002273:Carcinogens; D017608:Chromium Compounds; D001397:Azoxymethane
keywords: Azoxymethane; Chromium; Colorectal cancer; Insulin resistance; Mice