title: Effect of long-term pulsed electromagnetic field exposure on hepatic and immunologic functions of rats.
abstract: BACKGROUND
  In this report, the effects of long-term pulsed electromagnetic field (PEMF) exposure on hepatic and immunologic functions were examined.
  
  
  METHODS
  Male rats were randomly divided into four groups: a control group and three experimental groups exposed to a 50-Hz PEMF at 5, 10, or 20 mT for 10 weeks.
  
  
  RESULTS
  Compared with the control group, activities of serum alanine aminotransferase and aspartate aminotransferase and concentrations of serum, liver, and spleen Metabolism of lipid peroxidation (MDA) in the 10- and 20-mT PEMF groups were significantly increased. The activities of Glutathione peroxidase (GSH-Px) and Superoxide Dismutase (SOD) in the serum, liver, and spleen and concentrations of serum immunoglobulins were significantly decreased.
  
  
  CONCLUSIONS
  These results demonstrate that long-term exposure to PEMF can lead to oxidative damage of the liver and spleen.
authors.affiliation: Department of Orthopaedic Surgery, The First Hospital of Harbin City, Harbin Medical University, No. 149, Mai Mai Street, Dao Li District, 150001, Harbin, Heilongjiang Province, China.
authors.forename: Bao-lin
authors.initials: BL
authors.lastname: Li
authors.affiliation: Department of Orthopaedic Surgery, The First Hospital of Harbin City, Harbin Medical University, No. 149, Mai Mai Street, Dao Li District, 150001, Harbin, Heilongjiang Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Orthopaedic Surgery, The First Hospital of Harbin City, Harbin Medical University, No. 149, Mai Mai Street, Dao Li District, 150001, Harbin, Heilongjiang Province, China.
authors.forename: Jia-Qi
authors.initials: JQ
authors.lastname: Bi
authors.affiliation: Department of Orthopaedic Surgery, The First Hospital of Harbin City, Harbin Medical University, No. 149, Mai Mai Street, Dao Li District, 150001, Harbin, Heilongjiang Province, China.
authors.forename: Jian-gang
authors.initials: JG
authors.lastname: Zhao
authors.affiliation: Department of Orthopaedic Surgery, The First Hospital of Harbin City, Harbin Medical University, No. 149, Mai Mai Street, Dao Li District, 150001, Harbin, Heilongjiang Province, China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Qu
authors.affiliation: Department of Orthopaedic Surgery, The First Hospital of Harbin City, Harbin Medical University, No. 149, Mai Mai Street, Dao Li District, 150001, Harbin, Heilongjiang Province, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Lin
authors.affiliation: Department of Surgery, Harbin Medical University, No. 23, You Zheng Street, Nan Gang District, 150001, Harbin, Heilongjiang Province, China.
authors.forename: Song-Lin
authors.initials: SL
authors.lastname: Yang
authors.affiliation: Department of Orthopaedic Surgery, The First Hospital of Harbin City, Harbin Medical University, No. 149, Mai Mai Street, Dao Li District, 150001, Harbin, Heilongjiang Province, China. doctorbaolin@163.com.
authors.forename: Qing-gang
authors.initials: QG
authors.lastname: Meng
authors.affiliation: Department of Surgery, Harbin Medical University, No. 23, You Zheng Street, Nan Gang District, 150001, Harbin, Heilongjiang Province, China. libaolin0609@163.com.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yue
mesh_terms: D065638:Absorption, Radiation; D000818:Animals; D016207:Cytokines / Q000276:immunology; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D004781:Environmental Exposure; D007113:Immunity, Innate / Q000276:immunology* / Q000528:radiation effects; D008099:Liver / Q000276:immunology* / Q000528:radiation effects; D008137:Longitudinal Studies; D008297:Male; D018384:Oxidative Stress / Q000276:immunology* / Q000528:radiation effects; D011829:Radiation Dosage; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology* / Q000528:radiation effects; D014916:Whole-Body Irradiation / Q000379:methods
chemical_list: D016207:Cytokines
keywords: Immune system; Liver; Pulsed electromagnetic fields; Rat; Spleen