title: Vitamin D and the risk of preeclampsia--a nested case-control study.
abstract: We aimed to determine the relation between vitamin D deficiency in early pregnancy and preeclampsia. In a nested case-control study of 2496 pregnant women, we identified 39 women who developed preeclampsia and 120 non-preeclamptic controls. Blood was sampled in 12th gestational week and analyzed for serum vitamin D. Vitamin D levels were similar in women who developed preeclampsia, 52.2 ± 20.5 nmol/L, and controls, 48.6 ± 20.5 nmol/L, p = 0.3. In addition, vitamin D deficiency (<50 nmol/L) was found in a similar proportion of control group (51.7%) as those with severe preeclampsia (41.2%). Women with vitamin D deficiency were 3 cm shorter than those with normal vitamin D levels (p = 0.002). Our data do not support the hypothesis that vitamin D deficiency in early pregnancy is associated with preeclampsia, but we cannot rule out a relation later in gestation.
authors.affiliation: Department of Women's and Childen's Health, Karolinska Institute, Stockholm, Sweden.|Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.|Depatrment of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Gidlöf
authors.affiliation: Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
authors.forename: Aldo T
authors.initials: AT
authors.lastname: Silva
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
authors.forename: Sven
authors.initials: S
authors.lastname: Gustafsson
authors.affiliation: Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.|Depatrment of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Pelle G
authors.initials: PG
authors.lastname: Lindqvist
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012307:Risk Factors; D013548:Sweden; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications*
chemical_list: D014807:Vitamin D
keywords: Preeclampsia; height; nested case-control studies; seasonal variation; vitamin D