title: Therapeutics and vaccines against chikungunya virus.
abstract: Currently, there are no licensed vaccines or therapies available against chikungunya virus (CHIKV), and these were subjects discussed during a CHIKV meeting recently organized in Langkawi, Malaysia. In this review, we chart the approaches taken in both areas. Because of a sharp increase in new data in these fields, the present paper is complementary to previous reviews by Weaver et al. in 2012 and Kaur and Chu in 2013 . The most promising antivirals so far discovered are reviewed, with a special focus on the virus-encoded replication proteins as potential targets. Within the vaccines in development, our review emphasizes the various strategies in parallel development that are unique in the vaccine field against a single disease.
authors.affiliation: 1 Department of Food and Environmental Sciences, University of Helsinki , Helsinki, Finland .
authors.forename: Tero
authors.initials: T
authors.lastname: Ahola
authors.forename: Therese
authors.initials: T
authors.lastname: Couderc
authors.forename: Therese
authors.initials: T
authors.lastname: Courderc
authors.forename: Lisa F P
authors.initials: LF
authors.lastname: Ng
authors.forename: David
authors.initials: D
authors.lastname: Hallengärd
authors.forename: Ann
authors.initials: A
authors.lastname: Powers
authors.forename: Marc
authors.initials: M
authors.lastname: Lecuit
authors.forename: Mariano
authors.initials: M
authors.lastname: Esteban
authors.forename: Andres
authors.initials: A
authors.lastname: Merits
authors.forename: Pierre
authors.initials: P
authors.lastname: Roques
authors.forename: Peter
authors.initials: P
authors.lastname: Liljeström
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000998:Antiviral Agents / Q000627:therapeutic use*; D065632:Chikungunya Fever / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control*; D002646:Chikungunya virus / Q000276:immunology*; D008296:Malaysia; D014764:Viral Proteins / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D014764:Viral Proteins; D014765:Viral Vaccines
keywords: Antibodies; Antiviral; Attenuated virus; Chikungunya; DNA chimeric viruses; Polymerase; Protease; Vaccine; Virus-like particles