title: TIF-IA and Ebp1 regulate RNA synthesis in T cells.
abstract: In this issue of Blood, Nguyen et al show that mycophenolic acid (MPA) induces GTP depletion, which inhibits the function of transcription initiation factor I (TIF-IA) and impacts the interaction of TIF-IA with ErbB3-binding protein 1 (Ebp1), a key in regulating proliferating cell nuclear antigen (PCNA) expression and ribosomal RNA (rRNA) synthesis in T cells during activation.
authors.affiliation: ANTHONY NOLAN RESEARCH INSTITUTE; UNIVERSITY COLLEGE LONDON.
authors.forename: Aurore
authors.identifier: http://orcid.org/0000-0002-9376-8339
authors.initials: A
authors.lastname: Saudemont
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D006160:Guanosine Triphosphate / Q000378:metabolism*; D006801:Humans; D012335:RNA, Ribosomal / Q000096:biosynthesis*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D012335:RNA, Ribosomal; D016601:RNA-Binding Proteins; D006160:Guanosine Triphosphate