title: AI-2 to the rescue against antibiotic-induced intestinal dysbiosis?
abstract: The downside of antibiotic treatment of infectious diseases is a disturbed intestinal microbiota leading to reduced resistance against pathogen colonization. Work by Thompson et al. now suggests that antibiotic-induced intestinal dysbiosis can partially be counterbalanced by artificially increasing the levels of autoinducer-2 (AI-2), a well-known bacterial communication molecule.
authors.affiliation: Institute of Microbiology and Biotechnology, University of Ulm, 89068 Ulm, Germany; College of Life Sciences and Agriculture, Zhoukou Normal University, 466001, Zhoukou, China.
authors.forename: Zhongke
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Institute of Microbiology and Biotechnology, University of Ulm, 89068 Ulm, Germany.
authors.forename: Verena
authors.initials: V
authors.lastname: Grimm
authors.affiliation: Institute of Microbiology and Biotechnology, University of Ulm, 89068 Ulm, Germany. Electronic address: christian.riedel@uni-ulm.de.
authors.forename: Christian U
authors.initials: CU
authors.lastname: Riedel
mesh_terms: D000818:Animals; D006714:Homoserine / Q000031:analogs & derivatives*; D007422:Intestines / Q000382:microbiology*; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D064307:Microbiota / Q000187:drug effects*; D053038:Quorum Sensing
chemical_list: D007783:Lactones; D006714:Homoserine
keywords: antibiotics; autoinducer-2; dysbiosis; microbiota