title: Diastolic dysfunction in controlled hypertensive patients with mild-moderate obstructive sleep apnea.
abstract: BACKGROUND
  Hypertension and severe obstructive sleep apnea (OSA) may independently contribute to left ventricular diastolic dysfunction. However, scanty data is available on this issue in hypertensives with mild-moderate OSA.
  
  
  RESULTS
  We performed polysomnography, echocardiography and 24h ambulatory blood pressure monitoring in 115 treated essential hypertensives with suspicion of OSA. After exclusion of severe/treated OSA and/or cardiovascular disease patients, mild-moderate OSA (5 ≤ apnoea/hypopnoea index<30 events·h(-1)) was diagnosed in 47.3% of the remaining 91 patients, while 52.7% were free of OSA. Transmitral early (E) and late (A) peak flow velocities were assessed in 69 patients, and mitral annular velocity (E') in 53. Compared to non-OSA, mild-moderate OSA heart rate was higher (p=0.031) while E/A was lower (p<0.001) without differences in 24h mean systolic and diastolic blood pressures (125.36 ± 12.46/76.46 ± 6.97 vs 128.63 ± 11.50/77.70 ± 7.72 mmHg, respectively, NS). Patients with E'< 10 cm/s and E/A<0.8 showed a lower mean SpO2 than subjects with normal diastolic function (p=0.004; p<0.001). In a logistic regression model age, mean SpO2, daytime heart rate and nocturnal diastolic blood pressure fall were associated with altered relaxation pattern, independently from BMI and gender.
  
  
  CONCLUSIONS
  In controlled hypertensives mild-moderate OSA may be associated with early diastolic dysfunction, independently from age, gender and mean blood pressure and in the absence of concentric left ventricular hypertrophy. Moreover nocturnal hypoxia may be a key factor in determining early diastolic dysfunction, under the synergic effects of hypertension and mild-moderate OSA.
authors.affiliation: Dept. of Health Sciences, University of Milano-Bicocca, Milan, Italy; Dept. of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Lisi
authors.affiliation: Sleep Center, Dept. of Cardiovascular, Neural and Metabolic Diseases, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy; Dept. of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Faini
authors.affiliation: Dept. of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Bilo
authors.affiliation: Dept. of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy.
authors.forename: Laura Maria
authors.initials: LM
authors.lastname: Lonati
authors.affiliation: Dept. of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy.
authors.forename: Miriam
authors.initials: M
authors.lastname: Revera
authors.affiliation: Dept. of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Salerno
authors.affiliation: Dept. of Health Sciences, University of Milano-Bicocca, Milan, Italy; Dept. of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Giuli
authors.affiliation: Sleep Center, Dept. of Cardiovascular, Neural and Metabolic Diseases, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy.
authors.forename: Carolina
authors.initials: C
authors.lastname: Lombardi
authors.affiliation: Dept. of Health Sciences, University of Milano-Bicocca, Milan, Italy; Sleep Center, Dept. of Cardiovascular, Neural and Metabolic Diseases, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy; Dept. of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy. Electronic address: gianfranco.parati@unimib.it.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Parati
mesh_terms: D003971:Diastole; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications*; D018487:Ventricular Dysfunction, Left / Q000150:complications*
keywords: Hypertension; Left ventricular diastolic function; Obstructive sleep apnea