title: Electrophysiological endophenotypes in rodent models of schizophrenia and psychosis.
abstract: Schizophrenia is caused by a diverse array of risk factors and results in a similarly diverse set of symptoms. Electrophysiological endophenotypes lie between risks and symptoms and have the potential to link the two. Electrophysiological studies in rodent models, described here, demonstrate that widely differing risk factors result in a similar set of core electrophysiological endophenotypes, suggesting the possibility of a shared neurobiological substrate.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Rosen
authors.affiliation: Department of Physiology, College of Physicians and Surgeons, Columbia University, New York, New York.
authors.forename: Timothy
authors.initials: T
authors.lastname: Spellman
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York; Division of Integrative Neuroscience, New York State Psychiatric Institute, New York, New York.. Electronic address: jg343@columbia.edu.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Gordon
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal; D058068:Endophenotypes; D020022:Genetic Predisposition to Disease; D006801:Humans; D009433:Neural Inhibition; D011618:Psychotic Disorders / Q000235:genetics* / Q000503:physiopathology*; D051381:Rats; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology*; D012565:Schizophrenic Psychology
keywords: EEG; Excitation/inhibition balance; Local field potentials; Oscillations; Schizophrenia; Synaptic plasticity