title: Silver(I) complexes of 2,4-dihydroxybenzaldehyde-amino acid Schiff bases-Novel noncompetitive α-glucosidase inhibitors.
abstract: A series of silver(I) complexes of 2,4-dihydroxybenzaldehyde-amino acid Schiff bases were designed and tested for α-glucosidase inhibition. Our results indicate that all the silver complexes (4a-18a) possessed strong inhibitory activity at μmolL(-1) level, especially glutamine (12a) and histidine (18a) Schiff base silver(I) complexes exhibited an IC50 value of less than 0.01μmolL(-1). This series of compounds exhibited noncompetitive inhibition characteristics in kinetic studies. In addition, we investigated the mechanism of inhibition and the structure-activity relationships of the amino acid Schiff base silver complexes. Our results reveal that Schiff base silver complexes may be explored for their therapeutic potential as alternatives of α-glucosidase inhibitors.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, PR China. Electronic address: zhengjnw@mail2.sysu.edu.cn.
authors.forename: Jingwei
authors.initials: J
authors.lastname: Zheng
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D001547:Benzaldehydes; D065089:Glycoside Hydrolase Inhibitors; D012545:Schiff Bases; D012834:Silver; C032175:benzaldehyde
keywords: Amino acid Schiff bases; Noncompetitive inhibitors; Silver(I) complexes; α-Glucosidase