title: The association between triglyceride/high-density lipoprotein cholesterol ratio and all-cause mortality in acute coronary syndrome after coronary revascularization.
abstract: OBJECTIVE
  High triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) are cardiovascular risk factors. A positive correlation between elevated TG/HDL-C ratio and all-cause mortality and cardiovascular events exists in women. However, utility of TG to HDL-C ratio for prediction is unknown among acute coronary syndrome (ACS).
  
  
  METHODS
  Fasting lipid profiles, detailed demographic data, and clinical data were obtained at baseline from 416 patients with ACS after coronary revascularization. Subjects were stratified into three levels of TG/HDL-C. We constructed multivariate Cox-proportional hazard models for all-cause mortality over a median follow-up of 3 years using log TG to HDL-C ratio as a predictor variable and analyzing traditional cardiovascular risk factors. We constructed a logistic regression model for major adverse cardiovascular events (MACEs) to prove that the TG/HDL-C ratio is a risk factor.
  
  
  RESULTS
  The subject's mean age was 64 ± 11 years; 54.5% were hypertensive, 21.8% diabetic, and 61.0% current or prior smokers. TG/HDL-C ratio ranged from 0.27 to 14.33. During the follow-up period, there were 43 deaths. In multivariate Cox models after adjusting for age, smoking, hypertension, diabetes, and severity of angiographic coronary disease, patients in the highest tertile of ACS had a 5.32-fold increased risk of mortality compared with the lowest tertile. After adjusting for conventional coronary heart disease risk factors by the logistic regression model, the TG/HDL-C ratio was associated with MACEs.
  
  
  CONCLUSIONS
  The TG to HDL-C ratio is a powerful independent predictor of all-cause mortality and is a risk factor of cardiovascular events.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P. R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Wan
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P. R. China.
authors.forename: Jianxun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Division of Cardiology, the People's Hospital of Sichuan Province, Chengdu, Sichuan, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P. R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P. R. China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P. R. China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, P. R. China.
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Chen
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000401:mortality*; D000368:Aged; D002681:China / Q000453:epidemiology; D008076:Cholesterol, HDL / Q000097:blood*; D017023:Coronary Angiography; D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides