title: Chlamydia (uncomplicated, genital).
abstract: BACKGROUND
  Genital chlamydia is the most commonly reported bacterial sexually transmitted infection in developed countries. The majority of infections affect young adults under the age of 25 years.
  
  
  METHODS
  We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of antibiotic treatment for men and non-pregnant women with uncomplicated genital chlamydial infection? What are the effects of antibiotic treatment for pregnant women with uncomplicated genital chlamydial infection? We searched: Medline, Embase, The Cochrane Library, and other important databases up to February 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
  
  
  RESULTS
  We found 26 studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
  
  
  CONCLUSIONS
  In this systematic review we present information relating to the effectiveness and safety of the following interventions - for men and non-pregnant women: antibiotics (single-dose) and antibiotics (multiple-dose regimens); for pregnant women: antibiotics (single-dose), erythromycin or amoxicillin (multiple-dose regimens), and clindamycin (multiple-dose regimens).
authors.affiliation: Bristol Sexual Health Service, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
authors.forename: Megan
authors.initials: M
authors.lastname: Crofts
authors.forename: Paddy
authors.initials: P
authors.lastname: Horner
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002689:Chlamydia; D002690:Chlamydia Infections / Q000188:drug therapy*; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D005832:Genital Diseases, Male / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011247:Pregnancy
chemical_list: D000900:Anti-Bacterial Agents