title: Prognostic factors of lymphoma patients after autologous stem cell transplantation.
abstract: BacKGROUND: Hematopoietic stem cell transplantation (HSCT) is considered to be a cure for lymphoma. However, factors related to its prognosis remain unclear.
  
  
  METHODS
  Eighty patients diagnosed with lymphoma and treated with autologous HSCT (Auto HSCT) were recruited. The primary endpoints included overall survival (OS) and progression-free survival (PFS).
  
  
  RESULTS
  After a median follow-up of 37.9 months, the 3-year OS was 75%. Univariate analysis showed age (P=0.020), elevated lactate dehydrogenase (LDH) (P=0.031), international prognostic index (IPI) (P=0.015), Eastern Cooperative Oncology Group (ECOG) (P=0.048), bone marrow involvement (P=0.038), and time to neutrophil recovery (P=0.043) were prognostic factors of lymphoma. Multivariate analysis revealed IPI (hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.09-2.34, P=0.016) and time to neutrophil recovery (HR 2.69, 95% CI 1.02-7.07, P=0.045) were independent factors correlated with OS.
  
  
  CONCLUSIONS
  IPI and neutrophil recovery are recommendatory predictors for lymphoma patients after Auto HSCT.
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Fenghua
authors.initials: F
authors.lastname: Qian
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Wenxia
authors.initials: W
authors.lastname: Fan
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Xia
authors.initials: X
authors.lastname: Wei
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Gang
authors.initials: G
authors.lastname: Fu
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Dabing
authors.initials: D
authors.lastname: Qin
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Li
authors.initials: L
authors.lastname: Pei
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Shuangnian
authors.initials: S
authors.lastname: Xu
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Jieping
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Hematology, Southwestern Hospital, Third Military Medical University, Chongqing, China (mainland).
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008223:Lymphoma / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult