title: Itaya virus, a Novel Orthobunyavirus Associated with Human Febrile Illness, Peru.
abstract: Our genetic analyses of uncharacterized bunyaviruses isolated in Peru identified a possible reassortant virus containing small and large gene segment sequences closely related to the Caraparu virus and a medium gene segment sequence potentially derived from an unidentified group C orthobunyavirus. Neutralization tests confirmed serologic distinction among the newly identified virus and the prototype and Caraparu strains. This virus, named Itaya, was isolated in 1999 and 2006 from febrile patients in the cities of Iquitos and Yurimaguas in Peru. The geographic distance between the 2 cases suggests that the Itaya virus could be widely distributed throughout the Amazon basin in northeastern Peru. Identification of a new Orthobunyavirus species that causes febrile disease in humans reinforces the need to expand viral disease surveillance in tropical regions of South America.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Hontz
authors.forename: Carolina
authors.initials: C
authors.lastname: Guevara
authors.forename: Eric S
authors.initials: ES
authors.lastname: Halsey
authors.forename: Jesus
authors.initials: J
authors.lastname: Silvas
authors.forename: Felix W
authors.initials: FW
authors.lastname: Santiago
authors.forename: Steven G
authors.initials: SG
authors.lastname: Widen
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Wood
authors.forename: Wilma
authors.initials: W
authors.lastname: Casanova
authors.forename: Nikos
authors.initials: N
authors.lastname: Vasilakis
authors.forename: Douglas M
authors.initials: DM
authors.lastname: Watts
authors.forename: Tadeusz J
authors.initials: TJ
authors.lastname: Kochel
authors.forename: Hideki
authors.initials: H
authors.lastname: Ebihara
authors.forename: Patricia V
authors.initials: PV
authors.lastname: Aguilar
mesh_terms: D000328:Adult; D000818:Animals; D002044:Bunyaviridae Infections / Q000453:epidemiology* / Q000821:virology*; D002460:Cell Line; D005334:Fever / Q000453:epidemiology* / Q000821:virology*; D005843:Geography; D006801:Humans; D008297:Male; D009500:Neutralization Tests; D016851:Orthobunyavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D010568:Peru / Q000453:epidemiology; D010802:Phylogeny; D011159:Population Surveillance; D012367:RNA, Viral; D016865:Reassortant Viruses; D012703:Serotyping
chemical_list: D012367:RNA, Viral
keywords: Amazon; Caraparu virus; Itaya; Orthobunyavirus; Peru; arboviruses; bunyavirus; febrile surveillance; human pathogen; vector-borne infections; viruses