title: Progress and controversies in unraveling the glomerular filtration mechanism.
abstract: OBJECTIVE
  At first sight, the glomerular filter appears like a problem that should be easily solved. The majority of researchers view the filter like an impermeable wall perforated by specialized and size-selective pores (pore model). However, the fact that this model is in conflict with many of the experimental findings suggests that it may not yet be complete.
  
  
  RESULTS
  In the more recent electrokinetic model, we have proposed including electrical effects (streaming potentials). The present review investigates how this can provide a relatively simple mechanistic explanation for the great majority of the so far unexplained characteristics of the filter, for example why the filter never clogs.
  
  
  CONCLUSIONS
  Understanding how the glomerular filter functions is a prerequisite to investigate the pathogenesis of proteinuric glomerular diseases and the link between glomerular proteinuria and cardiovascular disease.
authors.affiliation: Division of Nephrology and Immunology, RWTH Aachen University, Aachen, Germany *Turgay Saritas and Christoph Kuppe contributed equally to the writing of this article.
authors.forename: Turgay
authors.initials: T
authors.lastname: Saritas
authors.forename: Christoph
authors.initials: C
authors.lastname: Kuppe
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Moeller
mesh_terms: D000818:Animals; D004727:Endothelium / Q000378:metabolism; D060730:Glomerular Filtration Barrier / Q000502:physiology*; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000473:pathology / Q000502:physiology*; D011507:Proteinuria / Q000378:metabolism*