title: [A multicenter study of correlation between peripheral lymphocyte counts and CD(+)4T cell counts in HIV/AIDS patients].
abstract: OBJECTIVE
  To evaluate the accuracy of lymphocyte count as a surrogate for CD(+)4T cell count in treatment-naїve HIV-infected adults.
  
  
  METHODS
  A total of 2 013 HIV-infected patients were screened at 23 sites in China. CD(+)4T cell counts were measured by flow cytometry. Correlation between CD(+)4T cell count and peripheral lymphocyte count were analyzed by spearman coefficient. AUCROC were used to evaluate the performance of lymphocyte count as a surrogate for CD(+)4T cell count.
  
  
  RESULTS
  The lymphocyte count and CD(+)4T cell count of these 2 013 patients were (1 600 ± 670) × 10(6)/L and (244 ± 148) × 10(6)/L respectively. CD(+)4T cell count were positively correlated with lymphocyte count (r = 0.482, P < 0.000 1). AUCROC of lymphocyte count as a surrogate for CD(+)4T cell counts of <100×10(6)/L, <200×10(6)/L and <350×10(6)/L were 0.790 (95%CI 0.761-0.818, P < 0.000 1), 0.733 (95%CI 0.710-0.755, P < 0.000 1) and 0.732 (95%CI 0.706-0.758, P < 0.000 1) respectively.
  
  
  CONCLUSIONS
  Lymphocyte count could be considerad as a potential surrogate marker for CD(+)4T cell count in HIV/AIDS patients not having access to T cell subset test by flowcytometry.
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Qiu
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.forename: Yanling
authors.initials: Y
authors.lastname: Li
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Song
authors.affiliation: Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. Email: litsh@263.net.
authors.forename: Taisheng
authors.initials: T
authors.lastname: Li
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology*; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002681:China; D005260:Female; D005434:Flow Cytometry; D015658:HIV Infections / Q000097:blood / Q000276:immunology*; D006801:Humans; D018655:Lymphocyte Count / Q000379:methods*; D008297:Male; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers