title: An unusual case of heterozygous hemoglobin S/hemoglobin Fannin-Lubbock misidentified by capillary hemoglobin electrophoresis.
abstract: A 58-year-old Hispanic man under treatment for a gangrenous toe was found to have chronic microcytic anemia and a positive sickle cell screen. High-performance liquid chromatography and isoelectric focusing electrophoresis showed that the patient is double heterozygous for hemoglobin S and hemoglobin Fannin-Lubbock. The patient does not have any manifestations of a sickling disorder. Capillary hemoglobin electrophoresis initially misclassified this unusual combination of hemoglobin variants.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas at Houston, Houston, TX, USA.
authors.forename: Kerry J
authors.initials: KJ
authors.lastname: Welsh
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Texas at Houston, Houston, TX, USA Yu.Bai@uth.tmc.edu.
authors.forename: Yu
authors.initials: Y
authors.lastname: Bai
mesh_terms: D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary / Q000379:methods*; D006451:Hemoglobin, Sickle / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D050505:Mutant Proteins / Q000235:genetics
chemical_list: D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; D050505:Mutant Proteins; C032030:hemoglobin Fannin-Lubbock