title: Chitosan-gum arabic polyelectrolyte complex films: physicochemical, mechanical and mucoadhesive properties.
abstract: By blending chitosan (CS) and gum arabic (GA), a powerful biomaterial complex might be obtained due to the unique properties of CS and the low viscosity and good emulsifying properties of GA. The objectives of this study were to prepare and examine the properties of dispersions and films of CS and GA as a function of the mixing weight ratio, pH value and molecular weight of CS. The dispersions were characterized by turbidity, zeta potential and cytotoxicity and then the dispersions were cast into films. Physicochemical properties of the film were performed. CS-GA dispersions exhibited higher turbidity and a lower zeta potential with an increase in the GA ratio. Continuous films of the CS-GA could be formed at all ratios. CS and GA could molecularly interact via electrostatic forces and intermolecular hydrogen bonding. The CS-GA (1:0.5) films exhibited relatively low water uptake, erosion, water vapor permeability and puncture strength compared to the CS films. Furthermore, the CS-GA films demonstrated good mucoadhesive properties, allowing for adhesion to the mucosal membrane. Based on these results, it could be advantageous to use CS-GA films as film formers for the formulation of coatings and drug delivery systems.
authors.affiliation: a Division of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences , Khon Kaen University , Khon Kaen , Thailand and.
authors.forename: Duangkamon
authors.initials: D
authors.lastname: Sakloetsakun
authors.affiliation: a Division of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences , Khon Kaen University , Khon Kaen , Thailand and.
authors.forename: Detpon
authors.initials: D
authors.lastname: Preechagoon
authors.affiliation: b Center for Molecular Biosciences Innsbruck, Department of Pharmaceutical Technology , Institute of Pharmacy, Leopold-Franzens-University of Innsbruck , Innsbruck , Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Bernkop-Schnürch
authors.affiliation: a Division of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences , Khon Kaen University , Khon Kaen , Thailand and.
authors.forename: Thaned
authors.initials: T
authors.lastname: Pongjanyakul
mesh_terms: D000269:Adhesives / Q000737:chemistry* / Q000378:metabolism; D001696:Biomechanical Phenomena; D018938:Caco-2 Cells; D055598:Chemical Phenomena; D048271:Chitosan / Q000737:chemistry* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D006170:Gum Arabic / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D000071228:Polyelectrolytes / Q000737:chemistry* / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013499:Surface Properties
chemical_list: D000269:Adhesives; D004337:Drug Carriers; D000071228:Polyelectrolytes; D006170:Gum Arabic; D048271:Chitosan
keywords: Chitosan; films; gum arabic; mechanical properties; mucoadhesive properties; polyelectrolyte complex