title: Successful treatment of disseminated adenovirus infection with ribavirin and intravenous immunoglobulin in an adult renal transplant recipient: a case report.
abstract: Disseminated adenovirus infection in recipients of renal transplants is a rare but often fatal complication. We present a case of a 32-year-old woman who underwent renal transplantation from a deceased donor. Ten months after transplantation, she presented with dysuria, hematuria, and febrile illness. Despite the use of antibiotics, the patient's symptoms continued and worsened and the serum creatinine level was increased. The results of urine and serum polymerase chain reaction were positive for adenovirus. Renal biopsy revealed viral interstitial nephritis. The patient was treated with ribavirin, intravenous immunoglobulin, and reduction in immunosuppression. Her symptoms progressively improved from 7 days after the treatment. Serum and urine polymerase chain reaction for adenovirus became negative 10 and 21 days after the treatment, respectively. She remained in good health with excellent allograft function 6 months later.
authors.affiliation: Division of Vascular and Transplantation Surgery, Keimyung University, Dongsan Medical Center, Daegu, Korea. Electronic address: parkuijun@gmail.com.
authors.forename: U J
authors.initials: UJ
authors.lastname: Park
authors.affiliation: Division of Vascular and Transplantation Surgery, Keimyung University, Dongsan Medical Center, Daegu, Korea.
authors.forename: S K
authors.initials: SK
authors.lastname: Hyun
authors.affiliation: Division of Vascular and Transplantation Surgery, Keimyung University, Dongsan Medical Center, Daegu, Korea.
authors.forename: H T
authors.initials: HT
authors.lastname: Kim
authors.affiliation: Division of Vascular and Transplantation Surgery, Keimyung University, Dongsan Medical Center, Daegu, Korea.
authors.forename: W H
authors.initials: WH
authors.lastname: Cho
authors.affiliation: Division of Nephrology, Keimyung University, Dongsan Medical Center, Daegu, Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Han
mesh_terms: D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use; D016030:Kidney Transplantation; D009395:Nephritis, Interstitial / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy*; D012254:Ribavirin / Q000627:therapeutic use*
chemical_list: D000998:Antiviral Agents; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D012254:Ribavirin