title: Effect of conjugated linoleic acid on blood pressure: a meta-analysis of randomized, double-blind placebo-controlled trials.
abstract: BACKGROUND
  Numerous studies on animals evidenced that conjugated linoleic acid (CLA) could decrease blood pressure (BP) in several rat models. However, such beneficial effect is not completely supported by studies on humans.
  
  
  METHODS
  We searched the Pubmed, Cochrane Library, and the ClinicalTrials.gov databases for relevant randomized, double-blind placebo-controlled trials up to August 2014 to perform a meta-analysis. A random-effects model was used to calculate the combined treatment effects.
  
  
  RESULTS
  Eight studies with nine trials, which involved 638 participants with CLA supplementation ranging from 2.0 g/day to 6.8 g/day, were included in this meta-analysis. Compared with placebo, the pooled estimate of change was -0.03 mm Hg (95% CI: -2.29, 2.24, P=0.98) and 0.69 mm Hg (95% CI: -1.41, 2.80, P=0.52) in systolic and diastolic BPs, respectively. No significant heterogeneity across studies for systolic BP; however, substantial heterogeneity for diastolic BP was identified. Publication bias was not found for both systolic and diastolic BPs.
  
  
  CONCLUSIONS
  The findings of this meta-analysis did not support the overall favorable effect of CLA supplementation on BP regulation.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Dushu Lake Higher Education Town, Suzhou, 215123, China. 82056512@qq.com.|Department of Clinical Nutrition, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China. 82056512@qq.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China. 14535251@qq.com.
authors.forename: Hai-Peng
authors.initials: HP
authors.lastname: Wang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Dushu Lake Higher Education Town, Suzhou, 215123, China. 1179617770@qq.com.
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Zhou
authors.affiliation: Department of Clinical Nutrition, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China. szzl_p@126.com.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China. chentan1234@sina.com.
authors.forename: Tan
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Dushu Lake Higher Education Town, Suzhou, 215123, China. qinliqiang@suda.edu.cn.
authors.forename: Li-Qiang
authors.initials: LQ
authors.lastname: Qin
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D044243:Linoleic Acids, Conjugated / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
chemical_list: D000959:Antihypertensive Agents; D044243:Linoleic Acids, Conjugated