title: [Antioxidant properties of conjugates of polyethylene glycols, having a terpenophenolic fragments].
abstract: A series of water-soluble conjugates has been synthesized from polyethylene glycols of various lengths and 4-bromomethyl-2,6-diisobornylphenol. Evaluation of membrane protective and antioxidant activity of synthesized products on the model of H2O2-induced hemolysis of blood erythrocytes showed that conjugates have considerable antioxidant activity. A significant membrane protective effect was showed in conjugates with 0.2 and 0.8 mass. % of 2,6-diisobornyl-4-methylene fragments.
authors.forename: I Yu
authors.initials: IY
authors.lastname: Chukicheva
authors.forename: M A
authors.initials: MA
authors.lastname: Torlopov
authors.forename: E V
authors.initials: EV
authors.lastname: Buravlev
authors.forename: O G
authors.initials: OG
authors.lastname: Shevchenko
authors.forename: A V
authors.initials: AV
authors.lastname: Kuchin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D010636:Phenols / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry; D014867:Water
chemical_list: D000975:Antioxidants; D010636:Phenols; D013729:Terpenes; D014867:Water; D011092:Polyethylene Glycols; D006861:Hydrogen Peroxide