title: [Synthesis, isomery, and hypotensive activity of thiethane-containing ylidenehydrazides of uracilylacetic acid].
abstract: Using reaction of hydrazide 2-[6-methyl-1-(thiethane3-yl)uracil-3-yl]acetic acid with arylaldehydes and acetophenone derivatives were obtained acylhydrazones, which exist in DMSO solution as a mixture of two stereoisomers of a E(C=N)-isomer for due to hindered internal rotation around the hydrazide bond. It was revealed that the synthesized compounds exhibit antihypertensive activity.
authors.forename: S A
authors.initials: SA
authors.lastname: Meshcheriakova
authors.forename: V A
authors.initials: VA
authors.lastname: Kataev
authors.forename: K V
authors.initials: KV
authors.lastname: Nikolaeva
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: D D
authors.initials: DD
authors.lastname: Borodin
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000473:pathology; D007536:Isomerism; D051381:Rats; D013329:Structure-Activity Relationship; D014498:Uracil / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000959:Antihypertensive Agents; D014498:Uracil