title: [Expression and clinical significance of Ki67 and calcitonin in medullary thyroid carcinoma].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of Ki67 and calcitonin in medullary thyroid carcinoma(MTC).
  
  
  METHODS
  The expression level of Ki67 and calcitonin was studied in 44 cases of medullary thyroid carcinoma tissue and 20 cases of adjacent nontumor tissue by SP immunohistochemistry.
  
  
  RESULTS
  The positive expression of Ki67 and calcitonin in medullary thyroid carcinoma tissue were 86.36% (38/44) and 100.00% (44/44) respectively. There was a significant difference between carcinoma and normal thyroid tissue (P<0.01). The overexpression of Ki67 and calcitonin in medullary thyroid carcinoma had no relationship with gender and age of patients,but had relationship with size of tumor,clinical staging and lymph node metastasis (P<0.05). Meanwhile, Ki67 and calcitonon had no significant correlation with each other.
  
  
  CONCLUSIONS
  The overexpression of Ki67 and calcitonin may play important role in occurrence, development and metastasis of medullary thyroid carcinoma. It may be used as an important judgement for the biological behavior of medullary thyroid carcinoma.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Feng
authors.forename: Jiadong
authors.initials: J
authors.lastname: Wang
mesh_terms: D002116:Calcitonin / Q000096:biosynthesis*; D018278:Carcinoma, Neuroendocrine; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008207:Lymphatic Metastasis; D013964:Thyroid Neoplasms / Q000378:metabolism*
chemical_list: D019394:Ki-67 Antigen; D002116:Calcitonin