title: [Gonadal function after treatment for a childhood or adolescent cancer].
abstract: Due to high cure rate in childhood and adolescent cancer, fertility preservation is a major concern. Chemotherapy, radiotherapy and surgery may alter gonadal function, and uterine cavity in women. In women, combined toxicity affecting both endocrine function and ovulation are observed leading to premature ovarian insufficiency. In men, spermatogenesis is frequently affected whereas endocrine function is almost always preserved. The current article focuses on investigations concerning gonadal function after treatment for a cancer during childhood or adolescence and treatment of subsequent infertility or hypogonadism. Nevertheless, those therapeutic are still limited and pretherapeutic preservation of fertility is preferred when possible.
authors.affiliation: Centre Léon-Bérard, département de chirurgie, 69008 Lyon, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Rousset-Jablonski
authors.affiliation: Centre d'étude et de conservation des œufs et du sperme humain (CECOS), hôpital femme-mère-enfant, 69500 Bron, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Giscard d'Estaing
authors.affiliation: Institut de cancérologie de Lorraine, département de radiothérapie, 54500 Vandœuvre-lès-Nancy, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Bernier
authors.affiliation: Hôpital Femme-Mère-Enfant, service de médecine de la reproduction, 69500 Bron, France.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Lornage
authors.affiliation: AP-HP, site de Bicêtre, service d'endocrinologie et de diabétologie pédiatrique, 94270 Le Kremlin-Bicêtre, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Thomas-Teinturier
authors.affiliation: Hôpital d'enfants, 95580 Margency, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Aubier
authors.affiliation: Institut d'hématologie et d'oncologie pédiatrique (IHOP), département d'oncologie pédiatrique, 69008 Lyon, France. Electronic address: cecile.conter@lyon.unicancer.fr.
authors.forename: Cécile
authors.initials: C
authors.lastname: Faure-Conter
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D059247:Fertility Preservation; D006801:Humans; D007246:Infertility / Q000209:etiology / Q000628:therapy*; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D065851:Ovarian Reserve / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D012737:Sex Factors; D017741:Survivors; D013737:Testis / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects
keywords: Cancer; Fertility; Fertilité; Insuffisance ovarienne; Ovarian failure; Spermatogenesis; Spermatogenèse; Traitement; Treatment