title: Effect of the CCND1 A870G polymorphism on prostate cancer risk: a meta-analysis of 3,820 cases and 3,825 controls.
abstract: BACKGROUND
  Cyclin D1 (CCND1) is critical in the transition of the cell cycle from the G1 to S phases, and unbalanced cell cycle regulation is a hallmark of carcinogenesis. Numerous epidemiological studies have evaluated the association between the CCND1 A870G polymorphism and the risk of prostate cancer (PCa). However, these studies have yielded conflicting results.
  
  
  METHODS
  In the present study, the possible association above was assessed by a meta-analysis. Eligible articles were identified for the period up to July 2014. Pooled odds ratios (ORs) with 95% confidence intervals (95% CI) were appropriately derived from fixed effects or random effects models.
  
  
  RESULTS
  A total of ten case-control studies, which included 3,820 cases and 3,825 controls, were identified. Overall, the allelic/genotypic association between the G870A polymorphism and prostate cancer was nonsignificant (OR = 1.045, 95% CI = 0.947 to 1.153 for A versus G, P = 0.380; OR = 1.088, 95% CI = 0.896 to 1.321 for AA versus GG, P = 0.393; OR = 1.044, 95% CI = 0.941 to 1.158 for GA versus GG, P = 0.414; OR = 1.053, 95% CI = 0.955 to 1.161 for the dominant model AA + GA versus GG, P = 0.303; OR = 1.072, 95% CI = 0.881 to 1.306 for the recessive model AA versus AA + GA, P = 0.486). Moreover, subgroup analyses according to ethnicity failed to demonstrate a significant association between this polymorphism and prostate cancer. In addition, we also performed a stratified analysis of cases with PCa metastasis, and the results supported the findings of no significant association between CCND1 A870G polymorphism and metastasis risk of PCa.
  
  
  CONCLUSIONS
  Our results suggest that the CCND1 A870G polymorphism might not be a potential candidate for predicting prostate cancer risk, including metastasis risk.
authors.affiliation: Department of Urology, Zhejiang Provincial People's Hospital, No.158 Shangtang Road, Hangzhou, Zhejiang, 310014, China. zhengminzj@163.com.
authors.forename: Min
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Department of Urology, Quzhou People's Hospital, No. 2 Zhongloudi Street, Quzhou, 310014, China. quzhouwanlijun@163.com.
authors.forename: Lijun
authors.initials: L
authors.lastname: Wan
authors.affiliation: Department of Urology, Zhejiang Provincial People's Hospital, No.158 Shangtang Road, Hangzhou, Zhejiang, 310014, China. wangyuanyuzj@163.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Urology, Zhejiang Provincial People's Hospital, No.158 Shangtang Road, Hangzhou, Zhejiang, 310014, China. Lililizj@126.com.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Urology, Zhejiang Provincial People's Hospital, No.158 Shangtang Road, Hangzhou, Zhejiang, 310014, China. Hexujunzj@126.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Urology, Zhejiang Provincial People's Hospital, No.158 Shangtang Road, Hangzhou, Zhejiang, 310014, China. urology@zju.edu.cn.
authors.forename: Da-Hong
authors.initials: DH
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D019938:Cyclin D1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1