title: Gemin5: A Multitasking RNA-Binding Protein Involved in Translation Control.
abstract: Gemin5 is a RNA-binding protein (RBP) that was first identified as a peripheral component of the survival of motor neurons (SMN) complex. This predominantly cytoplasmic protein recognises the small nuclear RNAs (snRNAs) through its WD repeat domains, allowing assembly of the SMN complex into small nuclear ribonucleoproteins (snRNPs). Additionally, the amino-terminal end of the protein has been reported to possess cap-binding capacity and to interact with the eukaryotic initiation factor 4E (eIF4E). Gemin5 was also shown to downregulate translation, to be a substrate of the picornavirus L protease and to interact with viral internal ribosome entry site (IRES) elements via a bipartite non-canonical RNA-binding site located at its carboxy-terminal end. These features link Gemin5 with translation control events. Thus, beyond its role in snRNPs biogenesis, Gemin5 appears to be a multitasking protein cooperating in various RNA-guided processes. In this review, we will summarise current knowledge of Gemin5 functions. We will discuss the involvement of the protein on translation control and propose a model to explain how the proteolysis fragments of this RBP in picornavirus-infected cells could modulate protein synthesis.
authors.affiliation: Medical Research Council Toxicology Unit, Lancaster Rd, Leicester LE1 9HN, UK. dpdr1@leicester.ac.uk.
authors.forename: David
authors.initials: D
authors.lastname: Piñeiro
authors.affiliation: Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Nicolas Cabrera 1, Madrid 28049, Spain. j.fernandez@csic.es.
authors.forename: Javier
authors.initials: J
authors.lastname: Fernandez-Chamorro
authors.affiliation: Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Nicolas Cabrera 1, Madrid 28049, Spain. rfrancisco@cbm.csic.es.
authors.forename: Rosario
authors.initials: R
authors.lastname: Francisco-Velilla
authors.affiliation: Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Nicolas Cabrera 1, Madrid 28049, Spain. emartinez@cbm.csic.es.
authors.forename: Encarna
authors.initials: E
authors.lastname: Martinez-Salas
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D010850:Picornaviridae Infections / Q000378:metabolism; D014176:Protein Biosynthesis; D055532:SMN Complex Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D055532:SMN Complex Proteins