title: Characterization of the roles of suppressor of cytokine signaling-3 in prostate cancer development and progression.
abstract: As negative feedback regulators of cytokine signaling, suppressor of cytokine signaling proteins are induced by interleukins and various peptide hormones and may prevent sustained activation of signaling pathways. In particular, suppressor of cytokine signaling-3 (SOCS-3) plays pivotal roles in the development and progression of various cancers and exerts pleiotropic effects on cell proliferation and apoptosis. In recent years, abnormal expression of SOCS-3 and its multiple functions have been extensively investigated in human carcinomas, particularly in prostate cancer. SOCS-3 can act as an oncogene or a tumor suppressor depending on the cellular context. In this review, we focus on the role of SOCS-3 in prostate cancer development and prognosis, as well as the potential of SOCS-3 as a therapeutic target and diagnostic marker.
authors.affiliation: Department of Urology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
authors.forename: Xian
authors.initials: X
authors.lastname: Fu
authors.forename: Ligang
authors.initials: L
authors.lastname: Ren
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Kaisen
authors.initials: K
authors.lastname: Liao
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Qian
authors.forename: Jiaquan
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000728:Androgens; D017209:Apoptosis; D018450:Disease Progression; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008745:Methylation; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism*
chemical_list: D000728:Androgens; D015850:Interleukin-6; D050826:Suppressor of Cytokine Signaling Proteins
keywords: androgen; interleukin-6; methylation; prostate cancer; suppressor of cytokine signaling-3