title: Mitochondrial epigenetics: an overlooked layer of regulation?
abstract: Despite decades of research, mitochondrial epigenetics remains a controversial notion. Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) methylation could underlie aging and disease. Unraveling such a level of regulation will be essential in the understanding of and in interfering with the role of mitochondria in many physiological and pathophysiological processes.
authors.affiliation: Epigenetic Editing, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen (UMCG), Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
authors.forename: Monique G P
authors.initials: MG
authors.lastname: van der Wijst
authors.affiliation: Epigenetic Editing, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen (UMCG), Hanzeplein 1, 9713 GZ Groningen, The Netherlands. Electronic address: m.g.rots@umcg.nl.
authors.forename: Marianne G
authors.initials: MG
authors.lastname: Rots
mesh_terms: D000818:Animals; D019175:DNA Methylation; D004272:DNA, Mitochondrial / Q000235:genetics; D044127:Epigenesis, Genetic; D050259:Genes, Mitochondrial; D006801:Humans; D008928:Mitochondria / Q000201:enzymology / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial
keywords: DNA hydroxymethylation; DNA methylation; mitochondrial epigenetics; mitoepigenetics; mtDNA; mtDNMT1