title: Specific brainstem and cortico-spinal reflex abnormalities in coexisting essential tremor and Parkinson's disease (ET-PD).
abstract: OBJECTIVE
  We aimed to analyze functional changes at brainstem and spinal levels in essential tremor (ET), Parkinson's disease (PD) and coexisting essential tremor and Parkinson's disease (ET-PD).
  
  
  METHODS
  Age- and gender-matched patients with tremor (15 ET, 7 ET with resting tremor, 25 ET-PD and 10 PD) and 12 healthy subjects were enrolled in the study. Diagnosis was established according to standardized clinical criteria. Electrophysiological studies included blink reflex (BR), auditory startle reaction (ASR) and long latency reflex (LLR).
  
  
  RESULTS
  Blink reflex was normal and similar in all groups. Probability of ASR was significantly lower in ET-PD group whereas it was similar to healthy subjects in ET and PD (P<0.001). LLR was recorded during voluntary activity in all three groups. LLR II was more common in ET, PD and ET-PD groups. LLR III was far more common in the PD group (n=3, 13.6% in ET; n=4, 16.0% in ET-PD and n=7, 46.7% in PD; p=0.037).
  
  
  CONCLUSIONS
  Despite the integrity of BR pathways, ASR and LLR show distinctive abnormalities in ET-PD. In our opinion, our electrophysiological findings support the hypothesis that ET-PD is a distinct entity.
authors.affiliation: Istanbul University, Cerrahpasa School of Medicine, Department of Neurology, 34098 K.M.Pasa, Istanbul, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Yavuz
authors.affiliation: Istanbul University, Cerrahpasa School of Medicine, Department of Neurology, 34098 K.M.Pasa, Istanbul, Turkey. Electronic address: draysegulgunduz@yahoo.com.
authors.forename: A
authors.initials: A
authors.lastname: Gündüz
authors.affiliation: Istanbul University, Cerrahpasa School of Medicine, Department of Neurology, 34098 K.M.Pasa, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ertan
authors.affiliation: Istanbul University, Cerrahpasa School of Medicine, Department of Neurology, 34098 K.M.Pasa, Istanbul, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Apaydın
authors.affiliation: Istanbul University, Cerrahpasa School of Medicine, Department of Neurology, 34098 K.M.Pasa, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Şifoğlu
authors.affiliation: Istanbul University, Cerrahpasa School of Medicine, Department of Neurology, 34098 K.M.Pasa, Istanbul, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Kiziltan
authors.affiliation: Istanbul University, Cerrahpasa School of Medicine, Department of Neurology, 34098 K.M.Pasa, Istanbul, Turkey.
authors.forename: M E
authors.initials: ME
authors.lastname: Kiziltan
mesh_terms: D000368:Aged; D001767:Blinking / Q000502:physiology; D001933:Brain Stem / Q000503:physiopathology*; D020329:Essential Tremor / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D011712:Pyramidal Tracts / Q000503:physiopathology*; D012021:Reflex, Abnormal; D013216:Reflex, Startle / Q000502:physiology
keywords: Auditory startle reflex; Blink reflex; Essential tremor; Essential tremor-Parkinson's disease; Long-latency reflex; Maladie de Parkinson; Parkinson's disease; Réaction de sursaut auditive; Réflexe de clignement; Réflexes de longue latence; Tremblement essentiel; Tremblement essentiel associé à la maladie de Parkinson