title: Cortical Morphology in Patients with Orthostatic Intolerance.
abstract: BACKGROUND
  We evaluated the cortical morphology in patients with orthostatic intolerance.
  
  
  METHODS
  Thirty patients with orthostatic intolerance, as well as age- and sex-matched normal controls, were enrolled in this study. We divided the patients into orthostatic hypotension (n = 22) and postural tachycardia syndrome (n = 8) groups based on their response to a head-up tilt table test. We analyzed whole-brain T1-weighted MRI images using FreeSurfer 5.1. The measures of cortical morphology were compared between the groups.
  
  
  RESULTS
  The cortical thickness in the right hemisphere, including the medial orbitofrontal, peri-calcarine, post-central, inferior temporal, and lateral occipital cortex, and in the peri-calcarine cortex of the left hemisphere was thinned in patients with orthostatic hypotension compared to normal controls. The other measures of cortical morphology, including the surface area, volume, and curvatures, did not differ between patients with orthostatic hypotension and normal controls. However, none of the measures of cortical morphology differed between patients with postural tachycardia syndrome and normal controls.
  
  
  CONCLUSIONS
  We demonstrated that the cortical morphology significantly changed in patients with orthostatic hypotension but not in patients with postural tachycardia syndrome compared to normal controls. These findings support the hypothesis that orthostatic intolerance is a heterogeneous syndrome.
authors.affiliation: Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
authors.forename: Kyong Jin
authors.initials: KJ
authors.lastname: Shin
authors.forename: Tae Hyung
authors.initials: TH
authors.lastname: Kim
authors.forename: Yong Hee
authors.initials: YH
authors.lastname: Han
authors.forename: Chi Woong
authors.initials: CW
authors.lastname: Mun
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Sam Yeol
authors.initials: SY
authors.lastname: Ha
authors.forename: Jin Se
authors.initials: JS
authors.lastname: Park
authors.forename: Kang Min
authors.initials: KM
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D054971:Orthostatic Intolerance / Q000473:pathology*; D011187:Posture / Q000502:physiology; D018667:Tilt-Table Test