title: The effects of different tensile parameters for the neurodynamic mobilization technique on tricipital muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury.
abstract: BACKGROUND
  After peripheral nerve injury, muscles without innervation begin to undergo atrophy. Research has suggested that MuRf-1 may play a role in muscle atrophy. The neurodynamic mobilization technique (NMT) is a manual therapy method used to elongate a nerve along its long axis, resulting in improved blood flow to the nerve. However, the nerve can be damaged if elongated too much. The purpose of this study is to observe the effect of NMT on muscle wet weight and MuRf-1 expression in rabbits with sciatic nerve injury.
  
  
  METHODS
  Six adult rabbits were measured to determine the relationship between the joint angle of the lower limb and percent of sciatic nerve elongation to define the tensile parameters of NMT; Thirty adult rabbits were randomly assigned into a sham, model, NMT-A, NMT-B, or NMT-C groups. Four weeks post-treatment, the wet mass of the tricipital muscles and MuRf-1 expression were observed.
  
  
  RESULTS
  The wet mass of the tricipital muscles in the NMT-B group was significantly greater than the NMT-A, NMT-C, and model groups. In addition, MuRf-1 expression was significantly reduced in the NMT-B group compared with the NMT-A, NMT-C, and model groups.
  
  
  CONCLUSIONS
  Elongating the nerve by NMT of 9% in rabbits decreased MuRf-1 expression and decelerated muscle atrophy in the subjects with sciatic nerve injury.
authors.affiliation: Rehabilitation medicine center of the second affiliated hospital of Heilongjiang university of Chinese medicine, Harbin, 150001, China. swallow-1113@163.com.|Rehabilitation medicine college of Heilongjiang university of Chinese medicine, Harbin, 150040, China. swallow-1113@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Rehabilitation medicine college of Heilongjiang university of Chinese medicine, Harbin, 150040, China. maming1987823@126.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Ma
authors.affiliation: Rehabilitation medicine center of the second affiliated hospital of Heilongjiang university of Chinese medicine, Harbin, 150001, China. tangqiang1963@163.com.|Rehabilitation medicine college of Heilongjiang university of Chinese medicine, Harbin, 150040, China. tangqiang1963@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Rehabilitation medicine center of the second affiliated hospital of Heilongjiang university of Chinese medicine, Harbin, 150001, China. zhuluwen1983@126.com.|Rehabilitation medicine college of Heilongjiang university of Chinese medicine, Harbin, 150040, China. zhuluwen1983@126.com.
authors.forename: Luwen
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, 63110, USA. koleinim@wusm.wustl.edu.
authors.forename: Melanie
authors.initials: M
authors.lastname: Koleini
authors.affiliation: Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, 63110, USA. zoud@wusm.wustl.edu.
authors.forename: Dequan
authors.initials: D
authors.lastname: Zou
mesh_terms: D000818:Animals; D001284:Atrophy / Q000517:prevention & control; D007596:Joints / Q000294:innervation / Q000503:physiopathology; D035002:Lower Extremity / Q000294:innervation / Q000503:physiopathology; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology*; D009929:Organ Size; D059348:Peripheral Nerve Injuries / Q000503:physiopathology / Q000534:rehabilitation*; D011817:Rabbits; D012584:Sciatic Nerve / Q000293:injuries*; D013718:Tensile Strength