title: Warfarin resistance due to VKORC1 gene mutation in a patient following mechanical aortic valve replacement with an ON-X valve.
authors.affiliation: Mater Misericordiae University Hospital, and Mater Private Hospital, Eccles St., Dublin 7, Ireland. Electronic address: kaosulli@tcd.ie.
authors.forename: Katie E
authors.initials: KE
authors.lastname: O' Sullivan
authors.affiliation: University Hospital Limerick, Limerick, Ireland.
authors.forename: Brendan
authors.initials: B
authors.lastname: Meany
authors.affiliation: Mater Misericordiae University Hospital, and Mater Private Hospital, Eccles St., Dublin 7, Ireland.
authors.forename: John P
authors.initials: JP
authors.lastname: Hurley
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000601:surgery; D000082882:Bicuspid Aortic Valve Disease; D001705:Bioprosthesis; D004351:Drug Resistance / Q000235:genetics*; D015150:Echocardiography, Doppler / Q000379:methods; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008297:Male; D009154:Mutation; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011182:Postoperative Care / Q000379:methods; D019233:Retreatment; D000069552:Rivaroxaban / Q000008:administration & dosage; D012720:Severity of Illness Index; D016896:Treatment Outcome; D064417:Vitamin K Epoxide Reductases / Q000235:genetics*; D014859:Warfarin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D014859:Warfarin; D000069552:Rivaroxaban; C578523:VKORC1 protein, human; D064417:Vitamin K Epoxide Reductases
keywords: Mutation; ON-X valve; VKORC1; Warfarin