title: The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States.
abstract: BACKGROUND
  The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management.
  
  
  METHODS
  We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma.
  
  
  RESULTS
  While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date.
  
  
  CONCLUSIONS
  It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.
authors.affiliation: Department of Pathology and Laboratory Medicine Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
authors.forename: Colleen S
authors.initials: CS
authors.lastname: Kraft
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine.
authors.forename: Angela L
authors.initials: AL
authors.lastname: Hewlett
authors.affiliation: Department of Pathology and Microbiology.
authors.forename: Scott
authors.initials: S
authors.lastname: Koepsell
authors.affiliation: Department of Pathology and Laboratory Medicine.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Winkler
authors.affiliation: Office of the Vice Chancellor for Research.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Kratochvil
authors.affiliation: Center for Clinical and Translational Research.
authors.forename: LuAnn
authors.initials: L
authors.lastname: Larson
authors.affiliation: Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
authors.forename: Jay B
authors.initials: JB
authors.lastname: Varkey
authors.affiliation: Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
authors.forename: Aneesh K
authors.initials: AK
authors.lastname: Mehta
authors.affiliation: Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
authors.forename: G Marshall
authors.initials: GM
authors.lastname: Lyon
authors.affiliation: Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
authors.forename: Rachel J
authors.initials: RJ
authors.lastname: Friedman-Moraco
authors.affiliation: Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
authors.forename: Vincent C
authors.initials: VC
authors.lastname: Marconi
authors.affiliation: Department of Pathology and Laboratory Medicine.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Hill
authors.affiliation: Division of Critical Care, Department of Anesthesiology, University of Nebraska Medical Center, Omaha.
authors.forename: James N
authors.initials: JN
authors.lastname: Sullivan
authors.affiliation: Division of Critical Care, Department of Anesthesiology, University of Nebraska Medical Center, Omaha.
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Johnson
authors.affiliation: Division of Critical Care, Department of Anesthesiology, University of Nebraska Medical Center, Omaha.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Lisco
authors.affiliation: Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mulligan
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Uyeki
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Anita K
authors.initials: AK
authors.lastname: McElroy
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Tara
authors.initials: T
authors.lastname: Sealy
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Shelley
authors.initials: S
authors.lastname: Campbell
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Christina
authors.initials: C
authors.lastname: Spiropoulou
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Ute
authors.initials: U
authors.lastname: Ströher
authors.affiliation: World Health Organization, Kenema Hospital, Sierra Leone.
authors.forename: Ian
authors.initials: I
authors.lastname: Crozier
authors.affiliation: University of Massachusetts Medical School, Worcester.
authors.forename: Richard
authors.initials: R
authors.lastname: Sacra
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Division of Renal Medicine, Department of Medicine, Emory University, Atlanta, Georgia.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Connor
authors.affiliation: Division of Pulmonary, Allergy and Critical Care.
authors.forename: Viranuj
authors.initials: V
authors.lastname: Sueblinvong
authors.affiliation: Division of Renal Medicine, Department of Medicine, Emory University, Atlanta, Georgia.
authors.forename: Harold A
authors.initials: HA
authors.lastname: Franch
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine.
authors.forename: Philip W
authors.initials: PW
authors.lastname: Smith
authors.affiliation: Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia.
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Ribner
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000627:therapeutic use*; D019142:Hemorrhagic Fever, Ebola / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D034741:RNA, Small Interfering / Q000627:therapeutic use*; D016896:Treatment Outcome; D014481:United States
chemical_list: D000914:Antibodies, Viral; D034741:RNA, Small Interfering
keywords: Ebola virus; Ebola virus disease; TKM-Ebola; convalescent plasma; convalescent serum