title: miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases.
abstract: MicroRNAs are involved in the initiation and progression of pancreatic cancer. In this study, we showed that miR-221/222 is overexpressed in pancreatic cancer. MiR-221/222 overexpression significantly promoted pancreatic cancer cell proliferation and invasion while inhibiting apoptosis. The expression of the matrix metalloproteinases (MMPs) MMP-2 and MMP-9 was increased in miR-221/222 mimic-transfected pancreatic cancer cells. Validation experiments identified TIMP-2 as a direct target of miR-221/222. These data indicate that overexpressed miR-221/222 may play an oncogenic role in pancreatic cancer by inducing the expression of MMP-2 and MMP-9, thus leading to cancer cell invasion.
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Qinhong
authors.initials: Q
authors.lastname: Xu
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.|Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zong
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Ligang
authors.initials: L
authors.lastname: Nan
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Lei
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Wanxing
authors.initials: W
authors.lastname: Duan
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Xuqi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Huanchen
authors.initials: H
authors.lastname: Sha
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Qingyong
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D018450:Disease Progression; D057809:HEK293 Cells; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D035683:MicroRNAs / Q000096:biosynthesis / Q000235:genetics*; D009857:Oncogenes; D010190:Pancreatic Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D014162:Transfection; D015854:Up-Regulation
chemical_list: D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D020782:Matrix Metalloproteinases; D035683:MicroRNAs; C525709:MIR221, human; C525710:MIR222, human; C522361:MMP2 protein, human; C579270:MMP9 protein, human
keywords: matrix metalloproteinases; miR-221/222; pancreatic cancer