title: Management of unbled brain arteriovenous malformation study.
abstract: In a recent trial limited to arteriovenous malformations discovered not to have bled, medical management was superior to medical management plus intervention. The trial was halted after 226 randomizations and a mean follow-up of 3.3 years owing to a disparity favoring the medical arm. Eligible patients were selected as suitable for lesion eradication. The initial sample size of 800 and follow-up plans for a mean of 7 years were lowered and shortened, respectively, by the outcome data. An application for extended follow-up was given poor priority scores owing to estimations that the disparities in outcomes would not change significantly.
authors.affiliation: Department of Neurology, Doris & Stanley Tananbaum Stroke Center, Neurological Institute, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA. Electronic address: jpm10@columbia.edu.
authors.forename: J P
authors.initials: JP
authors.lastname: Mohr
authors.affiliation: Department of Neurology, Doris & Stanley Tananbaum Stroke Center, Neurological Institute, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA.
authors.forename: Shadi
authors.initials: S
authors.lastname: Yaghi
mesh_terms: D057239:Early Termination of Clinical Trials; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic
keywords: Arteriovenous malformation; Interventional management; Medical management; Nonhemorrhagic presentation; Randomized clinical trial