title: Pharmacokinetics of micafungin in patients with pre-existing liver dysfunction: A safe option for treating invasive fungal infections.
abstract: In this prospective observational study performed in 12 hospitalized patients with proven or suspected invasive fungal infection treated for a mean of 14 days with micafungin (MCF), 8 of whom with pre-existing liver function impairment, plasma levels of MCF at steady state were not correlated with liver function tests at the beginning of treatment. Liver function remained stable or even improved in all patients, except in one in which MCF was discontinued due to liver toxicity.
authors.affiliation: Pharmacy Department, Hospital-del-Mar, Parc de Salut Mar, Paseo Marítimo 25-29, 08003 Barcelona, Spain; Institut Hospital del Mar d' Investigacions Mèdiques (IMIM), Barcelona, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Luque
authors.affiliation: Pharmacy Department, Hospital-del-Mar, Parc de Salut Mar, Paseo Marítimo 25-29, 08003 Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Campillo
authors.affiliation: Intensive Care Medicine Department, Hospital-del-Mar, Parc de Salut Mar, Paseo Marítimo 25-29, 08003 Barcelona, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Álvarez-Lerma
authors.affiliation: Pharmacy Department, Hospital-del-Mar, Parc de Salut Mar, Paseo Marítimo 25-29, 08003 Barcelona, Spain.
authors.forename: Olivia
authors.initials: O
authors.lastname: Ferrández
authors.affiliation: Infectious Diseases Department, Hospital-del-Mar, Parc de Salut Mar, Paseo Marítimo 25-29, 08003 Barcelona, Spain.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Horcajada
authors.affiliation: Pharmacy Department, Hospital-del-Mar, Parc de Salut Mar, Paseo Marítimo 25-29, 08003 Barcelona, Spain; Institut Hospital del Mar d' Investigacions Mèdiques (IMIM), Barcelona, Spain; Universitat Autònoma de Barcelona (UAB), Barcelona, Spain. Electronic address: sgrau@parcdesalutmar.cat.
authors.forename: Santiago
authors.initials: S
authors.lastname: Grau
mesh_terms: D000935:Antifungal Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D054714:Echinocandins / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000072742:Invasive Fungal Infections / Q000188:drug therapy / Q000378:metabolism*; D055666:Lipopeptides / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D000077551:Micafungin; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin
keywords: Hepatotoxicidad; Hepatotoxicity; Micafungin; Micafungina; Monitorización farmacocinética; Therapeutic drug monitoring