title: Nicotinamide adenine dinucleotide: An essential factor in preserving hearing in cisplatin-induced ototoxicity.
abstract: Ototoxicity is an important issue in patients receiving cisplatin chemotherapy. Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage, and inflammatory responses, are closely associated with cisplatin-induced ototoxicity. Although much attention has been directed at identifying ways to protect the inner ear from cisplatin-induced damage, the precise underlying mechanisms have not yet been elucidated. The cofactor nicotinamide adenine dinucleotide (NAD(+)) has emerged as an important regulator of cellular energy metabolism and homeostasis. NAD(+) acts as a cofactor for various enzymes including sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), and therefore, maintaining adequate NAD(+) levels has therapeutic benefits because of its effect on NAD(+)-dependent enzymes. Recent studies demonstrated that disturbance in intracellular NAD(+) levels is critically involved in cisplatin-induced cochlear damage associated with oxidative stress, DNA damage, and inflammatory responses. In this review, we describe the importance of NAD(+) in cisplatin-induced ototoxicity and discuss potential strategies for the prevention or treatment of cisplatin-induced ototoxicity with a particular focus on NAD(+)-dependent cellular pathways.
authors.affiliation: Center for Metabolic Function Regulation & Department of Microbiology, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Hyung-Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Center for Metabolic Function Regulation & Department of Microbiology, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Gi-Su
authors.initials: GS
authors.lastname: Oh
authors.affiliation: Center for Metabolic Function Regulation & Department of Microbiology, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: AiHua
authors.initials: A
authors.lastname: Shen
authors.affiliation: Center for Metabolic Function Regulation & Department of Microbiology, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Su-Bin
authors.initials: SB
authors.lastname: Lee
authors.affiliation: Center for Metabolic Function Regulation & Department of Microbiology, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Dipendra
authors.initials: D
authors.lastname: Khadka
authors.affiliation: Center for Metabolic Function Regulation & Department of Microbiology, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Arpana
authors.initials: A
authors.lastname: Pandit
authors.affiliation: Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Hyeok
authors.initials: H
authors.lastname: Shim
authors.affiliation: Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Sei-Hoon
authors.initials: SH
authors.lastname: Yang
authors.affiliation: Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Cho
authors.affiliation: Department of Sports Industry and Welfare, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Jeho
authors.initials: J
authors.lastname: Song
authors.affiliation: PAEAN Biotechnology, 160 Techno-2 Street, Yuseong-gu, Daejeon, 305-500, Republic of Korea.
authors.forename: Tae Hwan
authors.initials: TH
authors.lastname: Kwak
authors.affiliation: Center for Metabolic Function Regulation & Department of Microbiology, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Seong-Kyu
authors.initials: SK
authors.lastname: Choe
authors.affiliation: Center for Metabolic Function Regulation & Department of Microbiology, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
authors.forename: Raekil
authors.initials: R
authors.lastname: Park
authors.affiliation: Center for Metabolic Function Regulation & Department of Microbiology, School of Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea. Electronic address: jeanso@wku.ac.kr.
authors.forename: Hong-Seob
authors.initials: HS
authors.lastname: So
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D002945:Cisplatin / Q000009:adverse effects*; D004249:DNA Damage; D006309:Hearing / Q000187:drug effects / Q000502:physiology; D034381:Hearing Loss / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D009243:NAD / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D017382:Reactive Oxygen Species; D009243:NAD; D002945:Cisplatin