title: [Effect of anti-tuberculosis treatment in tuberculosis patients co-infected with human immunodeficiency virus in seven counties,Yunnan].
abstract: OBJECTIVE
  To understand the potential risk factors influencing the effect of standard anti-tuberculosis (TB) treatment for TB patients co-infected with human immunodeficiency virus (HIV) and provide evidence for the improvement of anti TB therapy.
  
  
  METHODS
  A retrospective study was conducted among 445 TB/HIV patients diagnosed and registered in 7 counties in Yunnan province from January 2010 to June 2012. A structured questionnaire was used to collect the patients' demographic characteristics, diagnosis and treatment information after informed consent. Chi-square test was conducted to compare successful rate of anti TB treatment among the patients with different demographic characteristics. Multivariate logistic regression analysis was conducted to identify risk factors influencing the effect of anti TB treatment. Adjusted OR>1 means the risk factor of treatment failure. P value less than 0.05 was set as significant level.
  
  
  RESULTS
  After standard anti TB treatment, 397 patients were cured. The five risk factors influencing treatment effect were the existing of 4 suspected TB symptoms when seeking medical care for the first time (adjusted OR = 2.208), TB/HIV patients detected in HIV/AIDS screening (adjusted OR = 5.856), severe case (adjusted OR = 4.607), non-full-course supervision during treatment (in intensive phase adjusted OR = 4.129, full-course management adjusted OR = 8.090) and interruption of therapy (adjusted OR = 21.517).
  
  
  CONCLUSIONS
  Early detection of TB/HIV patients and conducting full course supervision during treatment can improve the effect of anti TB treatment. It is necessary to strengthen the early detection of TB/HIV patients and standarded treatment in Yunnan province.
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.affiliation: School of Public Health, Kunming Medical University.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Gao
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China. Email: fafafa3936@126.com.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D002681:China; D060085:Coinfection; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D012189:Retrospective Studies; D012307:Risk Factors; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents