title: A comparison of an antibacterial sandwich dressing vs dressing containing silver.
abstract: The purpose of this study was to compare the efficacy of dressings containing octenidine vs. dressings containing silver in the wound healing in the course of a chronic venous disease. There were two groups of 40 patients who met the inclusion criteria and who did not meet the exclusion criteria. The patients were randomly assigned into the groups (envelope method). The first, "O group" was treated with octenidine-based dressings. The second, "S group" was treated with silver dressings. The study lasted for 56 days. All patients in the research were treated with medical compression stockings with cotton understockings. Microbiological eradication was observed on the 28th day of the study among 33% of patients in the treatment group vs. 6% in control group. On the 56th day of the treatment, these percentages equalled 72% and 35%. The rate of healing was faster in the 0 group than in the S group. In the wounds <10 cm(2) it was faster by 1.35 cm(2)/week and in wounds >10 cm(2) it equalled 3.44 cm(2). The reduction of pain level was 37.5% higher in the O group, in contrast with the S group. One change of a dressing in the O group led to a 0.06 cm(2) greater wound size reduction and in the case of wounds >10 cm(2) to 0.29 cm(2) reduction compared with the S group. The presented results indicate that the efficacy of dressings containing octenidine is higher compared to silver dressings.
authors.affiliation: Nutrikon, KCZ Surgical Ward, Krapkowice.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Krasowski
authors.affiliation: Department of Vascular Surgery and Angiology Collegium Medium in Bydgoszcz, University Hospital nr 1 Bydgoszcz.
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Jawień
authors.affiliation: Epidemiology Department, Oncology Center Institute Gliwice.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Tukiendorf
authors.affiliation: Department of Experimental Surgery and Biomaterials Research.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Rybak
authors.affiliation: Department of Pharmaceutical Microbiology and Parasitology, Wrocław Medical University, Wroclaw.
authors.forename: Adam
authors.initials: A
authors.lastname: Junka
authors.affiliation: Department of Public Health; Silesian Medical University, Bytom.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Olejniczak-Nowakowska
authors.affiliation: Department of Pharmaceutical Microbiology and Parasitology.
authors.forename: Marzenna
authors.initials: M
authors.lastname: Bartoszewicz
authors.affiliation: Pharmaceutical Microbiology and Parasitology, Wrocław Medical University, Wroclaw, Poland.
authors.forename: Danuta
authors.initials: D
authors.lastname: Smutnicka
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007097:Imines; D007871:Leg Ulcer / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011725:Pyridines / Q000008:administration & dosage*; D012834:Silver / Q000008:administration & dosage*; D053828:Stockings, Compression; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D007097:Imines; D011725:Pyridines; D012834:Silver; C034213:octenidine