title: Characterization of retinal structure and diagnosis of peripheral acquired retinoschisis using high-resolution ultrasound B-scan.
abstract: OBJECTIVE
  The purpose of the study was to report the ability of high-resolution ultrasonography (USG) B-Scan in differentiating between acquired retinoschisis (RS) and retinal detachment (RD), and to compare the findings with spectral-domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  Patients with acquired peripheral RS and RD undergoing imaging with high-resolution B-scan USG and SD-OCT were included in the study. Descriptive analysis was performed on the images obtained by high-resolution B-scan USG to identify various retinal interfaces. The findings were correlated with those obtained using the SD-OCT images.
  
  
  RESULTS
  Six eyes of five patients (two males) with RS and seven eyes of four patients (three males) with RD were included in the study. In all eyes of patients with RS, the outer retina demonstrated the presence of two hyper-reflective lines corresponding to the interfaces of the outer plexiform layer (OPL) and the retinal pigment epithelium (OPL). Eyes diagnosed with RD demonstrated two hyper-reflective lines in the detached portion, corresponding to the nerve fiber layer and OPL interfaces, whereas the attached portion demonstrated the presence of the third hyper-reflective interface, i.e., RPE. These findings correlated well with SD-OCT.
  
  
  CONCLUSIONS
  Analysis of retinal interfaces on high-resolution USG B-scan may allow precise differentiation of acquired RS from RD by identification of various retinal layers. These findings correlate well with SD-OCT.
authors.affiliation: Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA.|Department of Ophthalmology and Visual Sciences, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA.
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: Department of Ophthalmology and Visual Sciences, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA.
authors.forename: Shan
authors.initials: S
authors.lastname: Fan
authors.affiliation: Eye Clinic - Department of Biomedical and Clinical Science, Luigi Sacco Hospital -University of Milan, Milano, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Invernizzi
authors.affiliation: Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA.|Department of Ophthalmology and Visual Sciences, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Do
authors.affiliation: Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA.|Department of Ophthalmology and Visual Sciences, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA.
authors.forename: Quan Dong
authors.initials: QD
authors.lastname: Nguyen
authors.affiliation: Department of Ophthalmology and Visual Sciences, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA.
authors.forename: Nathan V
authors.initials: NV
authors.lastname: Harms
authors.affiliation: Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA. yasir.sepah@unmc.edu.|Department of Ophthalmology and Visual Sciences, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center, Omaha, USA. yasir.sepah@unmc.edu.
authors.forename: Yasir J
authors.initials: YJ
authors.lastname: Sepah
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D012160:Retina / Q000000981:diagnostic imaging*; D012163:Retinal Detachment / Q000000981:diagnostic imaging*; D055213:Retinal Pigment Epithelium / Q000648:ultrastructure; D041441:Retinoschisis / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence; D014463:Ultrasonography
keywords: High-resolution ultrasound; Multimodal imaging; Optical coherence tomography; Retinal detachment; Retinoschisis; Wide-field fundus photography