title: Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction.
abstract: BACKGROUND
  The metalloproteinase family of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) degrades extracellular matrix. However, the relevance of the ADAMTS family to cardiovascular diseases remains largely unknown. The study aimed to examine plasma ADAMTS-7 levels in patients with acute myocardial infarction (AMI) and the relationship between plasma ADAMTS-7 levels and heart function.
  
  
  METHODS
  This was a prospective study performed in 84 patients with ST-elevation myocardial infarction (STEMI), 70 patients with non-STEMI (NSTEMI), and 38 controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma ADAMTS-7 levels. Cardiac structure and function were assessed using two-dimensional transthoracic echocardiography. Patients were stratified according to left ventricular ejection fraction (LVEF) ≤ 35% or >35%.
  
  
  RESULTS
  Plasma ADAMTS-7 levels were higher in patients with LVEF ≤ 35% compared with those with LVEF >35% (6.73 ± 2.47 vs. 3.22 ± 2.05 ng/ml, P < 0.05). Plasma ADAMTS-7 levels were positively correlated with brain natriuretic peptide (BNP), left ventricular mass index (LVMI), left ventricular end-diastolic diameter (LVEDD), and left ventricular end-systolic diameter (LVESD) and negatively correlated with the 6-min walk test (P < 0.05). According to the receiver operating characteristic (ROC) curve, using a cutoff value of plasma ADAMTS-7 of 5.69 ng/ml was associated with a specificity of 61.0% and a sensitivity of 87.6% for the diagnosis of heart failure after AMI. Logistic regression analysis indicated that the association between ADAMTS-7 and heart failure after AMI was independent from traditional cardiovascular risk factors and other biomarkers (odds ratio = 1.236, 95% confidence interval: 1.023 to 1.378, P = 0.021).
  
  
  CONCLUSIONS
  Elevated ADAMTS-7 level may be involved in ventricular remodeling after AMI.
authors.affiliation: Department of Cardiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China. bjwwj2006@163.com.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Cardiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China. yifeng18@163.com.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Gynaecology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, China. liyiyang1980@163.com.
authors.forename: Yiyang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Cardiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China. veighlee@hotmail.com.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Cardiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China. keyuannan6666@aliyun.com.
authors.forename: Yuannan
authors.initials: Y
authors.lastname: Ke
authors.affiliation: Department of Cardiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China. wangyong1239117@sina.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, China-Japan Friendship Hospital, 2 Yinghua Dongjie, Beijing, 100029, China. victorzheng@sina.com.
authors.forename: Jingang
authors.initials: J
authors.lastname: Zheng
mesh_terms: D051722:ADAM Proteins / Q000097:blood*; D000071118:ADAMTS7 Protein; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology; D011446:Prospective Studies; D020257:Ventricular Remodeling
chemical_list: D015415:Biomarkers; D051722:ADAM Proteins; D000071118:ADAMTS7 Protein; C121534:ADAMTS7 protein, human