title: A cohort study of incident microalbuminuria in relation to HOMA-IR in Korean men.
abstract: BACKGROUND
  Despite the previous studies showing the relationship between microalbuminuria and insulin resistance, longitudinal effect of insulin resistance on development of microalbuminuria is not clearly identified in non-diabetic population.
  
  
  METHODS
  One thousand six hundred three non-diabetic Korean men without microalbuminuria in 2005 had been followed up for the development of microalbuminuria until 2010. Microalbuminuria was evaluated by urine-albumin creatinine ration, and insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Cox proportional hazards model was used to estimate the risk for microalbuminuria according to the tertile of HOMA-IR.
  
  
  RESULTS
  During 5465.8 person-y of average follow-up, microalbuminuria developed in 76 (4.7%) participants. Incidence of microalbuminuria increased in proportion to the level of HOMA-IR (tertile 1: 3.0%, tertile 2: 4.1%, tertile 3: 7.1%, P<0.001). When the 1st tertile of HOMA-IR was set as reference, hazard ratios and 95% confidence interval were 1.15 (0.56-2.35) and 2.07 (1.05-4.09) for those in the 2nd and 3rd tertiles of HOMA-IR, even after adjusting multiple covariates, respectively (P for linear trend=0.054).
  
  
  CONCLUSIONS
  Increased insulin resistance was a predictor of microalbuminuria in Korean men.
authors.affiliation: Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Sung Keun
authors.initials: SK
authors.lastname: Park
authors.affiliation: Health Promotion Center, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
authors.forename: Hyejin
authors.initials: H
authors.lastname: Chun
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. Electronic address: armani131@naver.com.
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Ryoo
authors.affiliation: Department of Family Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
authors.forename: Sang Wha
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
authors.forename: Hong Soo
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
authors.forename: Kyung Won
authors.initials: KW
authors.lastname: Shim
authors.affiliation: Department of Family Medicine, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
authors.forename: Choo Yon
authors.initials: CY
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
authors.forename: Dong-Ryeol
authors.initials: DR
authors.lastname: Ryu
authors.affiliation: Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors.forename: Taeg Su
authors.initials: TS
authors.lastname: Ko
authors.affiliation: Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors.forename: Eugene
authors.initials: E
authors.lastname: Kim
authors.affiliation: Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors.forename: Se-Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors.forename: Jai Hyung
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
authors.forename: Seok Jin
authors.initials: SJ
authors.lastname: Hong
authors.affiliation: Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Republic of Korea.
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Hong
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000175:diagnosis* / Q000208:ethnology* / Q000652:urine; D044466:Asian People / Q000208:ethnology*; D015331:Cohort Studies; D005500:Follow-Up Studies; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
keywords: HOMA-IR; Insulin resistance; Microalbuminuria