title: Parietal and intravascular innate mechanisms of vascular inflammation.
abstract: Sustained inflammation of the vessel walls occurs in a large number of systemic diseases (ranging from atherosclerosis to systemic vasculitides, thrombotic microangiopathies and connective tissue diseases), which are ultimately characterized by ischemia and end-organ failure. Cellular and humoral innate immunity contribute to a common pathogenic background and comprise several potential targets for therapeutic intervention. Here we discuss some recent advances in the effector and regulatory action of neutrophils and in the outcome of their interaction with circulating platelets. In parallel, we discuss novel insights into the role of humoral innate immunity in vascular inflammation. All these topics are discussed in light of potential clinical and therapeutic implications in the near future.
authors.affiliation: IRCCS Ospedale San Raffaele, via Olgettina 60, 20132, Milan, Italy. ramirez.giuseppealvise@hsr.it.|Università Vita Salute San Raffaele, via Olgettina 58, 20132, Milan, Italy. ramirez.giuseppealvise@hsr.it.
authors.forename: Giuseppe A
authors.initials: GA
authors.lastname: Ramirez
authors.affiliation: IRCCS Ospedale San Raffaele, via Olgettina 60, 20132, Milan, Italy. rovere.patrizia@hsr.it.|Università Vita Salute San Raffaele, via Olgettina 58, 20132, Milan, Italy. rovere.patrizia@hsr.it.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Rovere-Querini
authors.affiliation: IRCCS Ospedale San Raffaele, via Olgettina 60, 20132, Milan, Italy. sabbadini.mariagrazia@hsr.it.|Università Vita Salute San Raffaele, via Olgettina 58, 20132, Milan, Italy. sabbadini.mariagrazia@hsr.it.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Sabbadini
authors.affiliation: IRCCS Ospedale San Raffaele, via Olgettina 60, 20132, Milan, Italy. manfredi.angelo@hsr.it.|Università Vita Salute San Raffaele, via Olgettina 58, 20132, Milan, Italy. manfredi.angelo@hsr.it.
authors.forename: Angelo A
authors.initials: AA
authors.lastname: Manfredi
mesh_terms: D001792:Blood Platelets / Q000502:physiology; D006801:Humans; D056724:Immunity, Humoral / Q000502:physiology*; D007113:Immunity, Innate / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology; D014657:Vasculitis / Q000276:immunology* / Q000503:physiopathology