title: Galacto configured N-aminoaziridines: a new type of irreversible inhibitor of β-galactosidases.
abstract: A new type of galactose mimetics has been synthesized following a straightforward synthetic approach based on cyclohexene olefin aziridination reactions directed by hydroxyl substituents. These enantiomerically pure galacto-configured N-aminoaziridines are potent irreversible inhibitors of Aspergillus oryzae and Escherichia coliβ-galactosidases.
authors.affiliation: Medicinal Chemistry Laboratory (MedChemLab), Departament de Química Biomèdica, Institut de Química Avançada de Catalunya (IQAC-CSIC), Jordi Girona 18-26, Barcelona, 08034, Spain. amadeu.llebaria@iqac.csic.es.
authors.forename: Anna
authors.initials: A
authors.lastname: Alcaide
authors.forename: Ana
authors.initials: A
authors.lastname: Trapero
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Pérez
authors.forename: Amadeu
authors.initials: A
authors.lastname: Llebaria
mesh_terms: D001236:Aspergillus oryzae / Q000187:drug effects / Q000201:enzymology*; D001388:Aziridines / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D005690:Galactose / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001388:Aziridines; D004791:Enzyme Inhibitors; D001616:beta-Galactosidase; D005690:Galactose