title: Role of directional vacuum assisted breast biopsy in previously equivocal biopsies for breast masses suspicious for malignancy.
abstract: Among percutaneous biopsy techniques, the vacuum assisted breast biopsy (VAB) obtains large tissue samples to alleviate some of the limitations associated with conventional percutaneous biopsy techniques. We aimed to determine the efficacy of VAB in previous equivocal biopsies using the mammotome device.
  
  
  METHODS
  A prospective non-randomized efficacy study was planned and executed on 43 patients (42 women, 1 man) whose previous FNAC and/or CNB of breast masses yielded inconclusive results or were suspicious for cancer.
  
  
  RESULTS
  VAB revealed malignancy in 31 (72%) of the 43 patients. Among them, 23 were diagnosed as infiltrative ductal carcinoma (IDC) on VAB, 20 underwent surgery and the final histopathological diagnosis was the same in 19 of them. One patient showed ductal carcinoma-in-situ (DCIS) only in the surgical specimen. Other malignancies included infiltrating lobular carcinoma (ILC) in 5 patients and one each of DCIS, non- Hodgkin lymphoma (NHL) and metastasis from lung cancer. Benign lesions were detected in 12 (28%) patients. These included 8 fibroadenomas, 2 fibrocystic disease and 1 each of mastitis and breast abscess. Four patients with fibroadenoma underwent surgical excision.
authors.affiliation: Postgraduate Institute of Medical Education and Research, Department of Superspeciality of Gastroenterology, Division of GE Radiology, Chandigarh (UT) -160 012 India. debi_uma@yahoo.co.in.
authors.forename: U
authors.initials: U
authors.lastname: Debi
authors.forename: S
authors.initials: S
authors.lastname: Thulkar
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: M C
authors.initials: MC
authors.lastname: Sharma
authors.forename: V
authors.initials: V
authors.lastname: Seenu
authors.forename: S V S
authors.initials: SV
authors.lastname: Deo
authors.forename: S
authors.initials: S
authors.lastname: Agarwal
authors.forename: S
authors.initials: S
authors.lastname: Hari
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D062005:Biopsy, Large-Core Needle / Q000379:methods*; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D018567:Breast Neoplasms, Male / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D014618:Vacuum
chemical_list: D014408:Biomarkers, Tumor