title: Does Montelukast Have an Effect on Post-tonsillectomy Pain Control in Children? A Randomized Trial Study.
abstract: OBJECTIVE
  Tonsillectomy surgery is associated with severe postoperative pain that usually requires analgesics including opioids. Pain control is still a big problem after tonsillectomy surgery. We aimed to evaluate the efficacy of preemptive analgesia using montelukast for pediatric post-tonsillectomy pain management. This is the first-time use of montelukast in post-tonsillectomy pain.
  
  
  METHODS
  Double-blind, controlled-randomized study.
  
  
  METHODS
  University teaching and research hospital.
  
  
  METHODS
  A total of 60 children, aged 5 to 15 years, American Society of Anesthesiologist class I-II, scheduled for elective tonsillectomy were enrolled in this clinical trial study. The patients were randomized into 2 groups: the montelukast group (group M, n = 30) and control group (group C, n = 30). Group M recieved an oral montelukast tablet and group C recieved placebo at 2400pm on the morning before surgery. Post-tonsillectomy pain was evaluated with the Wong-Baker FACES Scale during the 24 hours after surgery. Patients' intraoperative hemodynamic parameters and intraoperative and postoperative complications were recorded.
  
  
  RESULTS
  There were statistically significant differences between group C and group M for Wong-Baker FACES pain rating scale scores (P < .05). In the 24 hours after surgery, the total number of patients using rescue analgesics was higher in group C than in group M, and the difference was statistically significant (P < .001). There was no significant difference in demographic parameters (P > .05). There were no significant differences in postoperative nausea and vomiting, otalgia, trismus, fever, or halitosis between the groups (P > .05).
  
  
  CONCLUSIONS
  Preemptive montelukast can be used safely to reduce the serious pain caused by tonsillectomy in children.
authors.affiliation: Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey ilkerince1983@yahoo.com.
authors.forename: Ilker
authors.initials: I
authors.lastname: Ince
authors.affiliation: Department of Otorhinolaryngology, Ataturk University School of Medicine, Erzurum, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Yoruk
authors.affiliation: Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ahiskalioglu
authors.affiliation: Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aksoy
authors.affiliation: Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey.
authors.forename: Aysenur
authors.initials: A
authors.lastname: Dostbil
authors.affiliation: Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey.
authors.forename: Mine
authors.initials: M
authors.lastname: Celik
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000293:Adolescent; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003521:Cyclopropanes; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011804:Quinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D013440:Sulfides; D013607:Tablets; D014068:Tonsillectomy
chemical_list: D000085:Acetates; D000700:Analgesics; D003521:Cyclopropanes; D011804:Quinolines; D013440:Sulfides; D013607:Tablets; C093875:montelukast
keywords: montelukast; pediatrics; post-tonsillectomy analgesia; tonsillectomy