title: Reduced default mode network connectivity in schizophrenia patients.
abstract: In the present study, we explored possible alterations in the default mode network (DMN) and its functional connectivity in 41 schizophrenia patients and 42 age-matched healthy controls. Schizophrenia patients displayed reduced activation in the ventromedial prefrontal cortex, left superior temporal gyrus including auditory cortex and temporal pole. Psychophysiological interaction analysis revealed reduced connectivity between left superior temporal gyrus including auditory cortex and the left temporal pole in schizophrenia patients compared to healthy subjects.
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany. Electronic address: anne.pankow@charite.de.
authors.forename: Anne
authors.initials: A
authors.lastname: Pankow
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany; Max Planck Fellow Group 'Cognitive and Affective Control of Behavioral Adaption', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Department of Neurology, Otto von Guericke University, Magdeburg, Germany.
authors.forename: Lorenz
authors.initials: L
authors.lastname: Deserno
authors.affiliation: Department of Neurology, Otto von Guericke University, Magdeburg, Germany; Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany; Leibniz Institute for Neurobioloy, Magdeburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Walter
authors.affiliation: Department of Psychology, Humboldt-Universität zu Berlin, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Fydrich
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Bermpohl
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany; Max Planck Fellow Group 'Cognitive and Affective Control of Behavioral Adaption', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Schlagenhauf
authors.affiliation: Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Heinz
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000098:blood supply / Q000473:pathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000098:blood supply / Q000503:physiopathology*; D009434:Neural Pathways / Q000098:blood supply / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D011601:Psychophysics; D012559:Schizophrenia / Q000188:drug therapy / Q000473:pathology*
chemical_list: D014150:Antipsychotic Agents; D010100:Oxygen
keywords: Default mode network; Functional imaging; Schizophrenia