title: The non-coding RNAs of the H19-IGF2 imprinted loci: a focus on biological roles and therapeutic potential in Lung Cancer.
abstract: Since it was first described, the imprinted cluster 11p15.5 has been reported to be deregulated in a variety of pediatric and adult cancers including that of the lung. Both protein coding and non-coding genes functioning as oncogenes or as tumor suppressor genes reside within this cluster. Oncomirs that can function as oncogenes or as tumor suppressors have also been reported. While a complete account of the role played by the 11p15.5 imprinted cluster in lung cancer is beyond the scope of this review, we will focus on the role of the non-coding RNAs processed from the H19-IGF2 loci. A special emphasis will be given to the H19/miR-675 gene locus. Their potential diagnostic and therapeutic use in lung cancer will be described.
authors.affiliation: Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel. imad.matouq@mail.huji.ac.il.
authors.forename: Imad J
authors.initials: IJ
authors.lastname: Matouk
authors.affiliation: Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel. halledavid57@gmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Halle
authors.affiliation: Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel. michal.gilon@biocancell.com.
authors.forename: Michal
authors.initials: M
authors.lastname: Gilon
authors.affiliation: Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel. avraham.hochberg@biocancell.com.
authors.forename: Abraham
authors.initials: A
authors.lastname: Hochberg
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000473:pathology; D056426:Genetic Loci; D018392:Genomic Imprinting; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D035683:MicroRNAs / Q000378:metabolism; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding