title: Adherence to Infliximab Treatment in a Pediatric Inflammatory Bowel Disease Cohort.
abstract: The aims of the study were to describe infliximab adherence in a pediatric inflammatory bowel disease cohort, to identify demographic and disease factors associated with adherence, and to examine differences in acute care use among adherent and nonadherent patients. Charts of patients who received infliximab at the Children's Hospital of Wisconsin (CHW) between October 2010 and October 2012 were retrospectively reviewed. A total of 151 patients met the inclusion criteria; 91.4% of the patients were adherent. Nonadherent patients had more emergency room visits and hospitalizations than adherent patients. The study is the first to show high adherence rates to infliximab in a pediatric cohort.
authors.affiliation: *Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI †Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago, IL.
authors.forename: David S
authors.initials: DS
authors.lastname: Vitale
authors.forename: Rachel N
authors.initials: RN
authors.lastname: Greenley
authors.forename: Diana G
authors.initials: DG
authors.lastname: Lerner
authors.forename: Alisha M
authors.initials: AM
authors.lastname: Mavis
authors.forename: Steven L
authors.initials: SL
authors.lastname: Werlin
mesh_terms: D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy; D003424:Crohn Disease / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy; D004636:Emergency Service, Hospital; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006760:Hospitalization; D006776:Hospitals, Pediatric; D006801:Humans; D000069285:Infliximab / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D060046:Maintenance Chemotherapy; D008297:Male; D008499:Medical Records; D055118:Medication Adherence; D012189:Retrospective Studies; D000067251:Symptom Flare Up; D014922:Wisconsin
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005765:Gastrointestinal Agents; D000069285:Infliximab