title: Predictors for diagnosis of tick-borne encephalitis infection in Poland, 2009-2010.
abstract: BACKGROUND
  Tick-borne encephalitis (TBE) is a viral infection with no available treatment. Due to its non-specific symptoms, TBE tends to be under-diagnosed and under-reported. We aimed to identify factors predicting TBE diagnosis to develop a diagnostic algorithm for use by physicians.
  
  
  METHODS
  We conducted a case-control study using data routinely collected in Poland during 2009-2010. We included patients admitted to hospitals, who were assigned an International Classification of Disease (ICD) code indicating aseptic meningo-encephalitis. Cases were confirmed by detection of specific IgG and IgM antibodies. Patients that tested negative for TBE were included as controls. We used logistic regression to determine associations and recursive partitioning to build a diagnostic algorithm based on 70% of the dataset, and validated the algorithm using the remaining 30%.
  
  
  RESULTS
  Of 774 patients, 273 (35%) were TBE-positive. Cerebrospinal fluid protein levels and presence of a tick bite were key decision points in the algorithm, while living in a TBE endemic area was not important. Application of the algorithm to the validation dataset yielded a sensitivity of 89% and specificity of 37%.
  
  
  CONCLUSIONS
  TBE should be included in routine diagnostic protocols for all cases admitted to hospitals with meningitis or encephalitis. However, in resource-limited settings and in regions with unknown TBE endemicity status, our algorithm could indicate which cases should be tested for TBE.
authors.affiliation: From the 1 European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control (ECDC) , Stockholm , Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Zielicka-Hardy
authors.forename: Magdalena
authors.initials: M
authors.lastname: Rosińska
authors.forename: Maciej
authors.initials: M
authors.lastname: Kondrusik
authors.forename: Maria
authors.initials: M
authors.lastname: Hlebowicz
authors.forename: Ryszard
authors.initials: R
authors.lastname: Konior
authors.forename: Paweł
authors.initials: P
authors.lastname: Stefanoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004675:Encephalitis, Tick-Borne / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies; D055815:Young Adult
keywords: Poland; Tick-borne encephalitis; algorithm; diagnosis; recursive partitioning