title: The mitochondrial unselective channel in Saccharomyces cerevisiae.
abstract: Opening of the mitochondrial permeability transition (MPT) pore mediates the increase in the unselective permeability to ions and small molecules across the inner mitochondrial membrane. MPT results from the opening of channels of unknown identity in mitochondria from plants, animals and yeast. However, the effectors and conditions required for MPT to occur in different species are remarkably disparate. Here we critically review previous and recent findings concerning the mitochondrial unselective channel of the yeast Saccharomyces cerevisiae to determine if it can be considered a counterpart of the mammalian MPT pore.
authors.affiliation: Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO 65211, USA. Electronic address: manu@unam.mx.
authors.forename: Manuel
authors.initials: M
authors.lastname: Gutiérrez-Aguilar
authors.affiliation: Molecular Genetics Department, Instituto de Fisiología Celular, UNAM, Mexico City, Mexico.
authors.forename: Salvador
authors.initials: S
authors.lastname: Uribe-Carvajal
mesh_terms: D007473:Ion Channels / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000201:enzymology* / Q000378:metabolism*; D000083162:Mitochondrial Permeability Transition Pore; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore
keywords: Bioenergetics; Cell death; Mitochondrial evolution; Mitochondrial unselective channel; Permeability transition pore; Yeast mitochondria