title: Pharmaceutical spray freeze drying.
abstract: Pharmaceutical spray-freeze drying (SFD) includes a heterogeneous set of technologies with primary applications in apparent solubility enhancement, pulmonary drug delivery, intradermal ballistic administration and delivery of vaccines to the nasal mucosa. The methods comprise of three steps: droplet generation, freezing and sublimation drying, which can be matched to the requirements given by the dosage form and route of administration. The objectives, various methods and physicochemical and pharmacological outcomes have been reviewed with a scope including related fields of science and technology.
authors.affiliation: Laboratory of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Wanning
authors.affiliation: Laboratory of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany.
authors.forename: Richard
authors.initials: R
authors.lastname: Süverkrüp
authors.affiliation: Laboratory of Pharmaceutical Technology and Biopharmaceutics, Institute of Pharmacy, University of Bonn, Bonn, Germany; Laboratory of Pharmaceutical Engineering (EA4267), University of Franche-Comté, Besançon, France. Electronic address: alf.lamprecht@uni-bonn.de.
authors.forename: Alf
authors.initials: A
authors.lastname: Lamprecht
mesh_terms: D000336:Aerosols / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D005079:Excipients / Q000737:chemistry; D005612:Freeze Drying / Q000379:methods*; D007328:Insulin / Q000008:administration & dosage; D010316:Particle Size; D011208:Powders / Q000737:chemistry; D011994:Recombinant Proteins; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*; D014612:Vaccines / Q000008:administration & dosage; D042461:Vascular Endothelial Growth Factor A / Q000008:administration & dosage
chemical_list: D000336:Aerosols; D005079:Excipients; D007328:Insulin; D011208:Powders; D011994:Recombinant Proteins; D012997:Solvents; D014612:Vaccines; D042461:Vascular Endothelial Growth Factor A
keywords: Lyophilisation; Porous particles; Protein formulations; Pulmonary application; Spray freeze drying; Vaccination