title: Does Topical Application of Placental Extract Gel on Postoperative Fibrotomy Wound Improve Mouth Opening and Wound Healing in Patients With Oral Submucous Fibrosis?
abstract: OBJECTIVE
  Placental extract has been used as a therapeutic agent with application in various fields of medicine. Placental extract is well known for its effects on wound healing with anti-inflammatory, antiplatelet, and angiogenic effects and is also a biogenic modulator. The present study evaluated the effect of placental extract on wound healing, mouth opening, and postoperative patient discomfort in patients with oral submucous fibrosis treated with fibrotomy with buccal fat pad coverage and coronoidectomy.
  
  
  METHODS
  Ten subjects with oral submucous fibrosis who presented with mouth opening less than 20 mm were enrolled in the present prospective randomized controlled trial to assess the effects of placental extract on the fibrotomy wound covered with a pedicled buccal pad fat (5 patients allocated to the study group, group S and 5 to the control group, group C). The following criteria were used to analyze the postoperative effect of placental extract on fibrotomy wounds compared with that of the controls: subjective assessment of the wound, postoperative discomfort, and postoperative mouth opening assessed at 1, 2, and 4 weeks postoperatively.
  
  
  RESULTS
  The average difference in the preoperative and fourth week postoperative mouth opening for group C was 13.8 ± 2.68 mm and was 21.20 ± 2.77 mm in group S. The median calculated for group C was a 15.0-mm increase in mouth opening and was 20.0 mm in group S.
  
  
  CONCLUSIONS
  The results obtained with topical application of placental extract on fibrotomy wound healing and postoperative mouth opening were superior to those of the control group in whom placental extract was not used.
authors.affiliation: Reader, Department of Oral and Maxillofacial Surgery, People's College of Dental Sciences and Research Center, Bhopal, India.
authors.forename: Gagan
authors.initials: G
authors.lastname: Thakur
authors.affiliation: Professor and Head, Department of Oral and Maxillofacial Surgery, People's College of Dental Sciences and Research Center, Bhopal, India.
authors.forename: Shaji
authors.initials: S
authors.lastname: Thomas
authors.affiliation: Senior Lecturer, Department of Oral and Maxillofacial Surgery, People's College of Dental Sciences and Research Center, Bhopal, India. Electronic address: emaildarpan@gmail.com.
authors.forename: Darpan
authors.initials: D
authors.lastname: Bhargava
authors.affiliation: Postgraduate Student, Department of Oral and Maxillofacial Surgery, People's College of Dental Sciences and Research Center, Bhopal, India.
authors.forename: Ankit
authors.initials: A
authors.lastname: Pandey
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation; D058956:Administration, Mucosal; D000328:Adult; D064592:Autografts / Q000637:transplantation; D003238:Connective Tissue / Q000187:drug effects / Q000601:surgery; D004848:Epithelium / Q000473:pathology; D005500:Follow-Up Studies; D005782:Gels; D006097:Granulation Tissue / Q000473:pathology; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery; D009061:Mouth Mucosa / Q000187:drug effects* / Q000601:surgery; D009914:Oral Submucous Fibrosis / Q000601:surgery*; D010147:Pain Measurement / Q000379:methods; D010149:Postoperative Pain / Q000517:prevention & control*; D026741:Physical Therapy Modalities; D010924:Placental Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D014313:Trismus / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D005782:Gels; D010924:Placental Extracts