title: Hypertension and its correlation with renal lesions in dogs with leishmaniosis.
abstract: To evaluate the prevalence of hypertension and its correlation with the severity of renal injury and proteinuria in dogs with leishmaniosis, sixty-six dogs were divided into two groups. Group 1 (G1) was composed of 54 dogs included in stage 1 of chronic kidney disease (CKD), and group 2 (G2) of twelve dogs in stages 2 and 3 of CKD. Prevalence of hypertension was 28.8%, comprising 22.2% of the dogs from G1 and 58.3% from G2 (P=0.011). The mean arterial blood pressure (BP) of dogs from G1 (135.7 ± 20.5) was lower than from G2 (170.0 ± 26.3) (P <0.001). Urine protein-creatinine ratio (UP/C) revealed values above 0.5 in 75.7% of the dogs, with 34% presenting hypertension. All dogs with hypertension had histopathological and laboratory evidence of glomerular disease. Although there was no statistically significant correlation between elevated BP and the severity of glomerular lesions (P=0.408), there was a statistically significant correlation between elevated BP and increased UP/C in the studied population (P=0.002). Thus, dogs with leishmaniosis and renal disease must be screened for the presence of hypertension so that treatment may be instituted as early as possible, in countries where treatment is allowed, to prevent the progression of renal damage.
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
authors.forename: Eveline Tozzi
authors.initials: ET
authors.lastname: Braga
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
authors.forename: João Henrique Artero de Carvalho
authors.initials: JH
authors.lastname: Leite
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
authors.forename: Fernando Azadinho
authors.initials: FA
authors.lastname: Rosa
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Tivelli
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
authors.forename: Amanda Mariano
authors.initials: AM
authors.lastname: Araújo
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
authors.forename: Breno Fernando Martins
authors.initials: BF
authors.lastname: de Almeida
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
authors.forename: Heitor Flávio
authors.initials: HF
authors.lastname: Ferrari
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
authors.forename: Paulo César
authors.initials: PC
authors.lastname: Ciarlini
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
authors.forename: Gisele Fabrino
authors.initials: GF
authors.lastname: Machado
authors.affiliation: Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Universidade Estadual Paulista, Araçatuba, SP, Brasil.
authors.forename: Mary
authors.initials: M
authors.lastname: Marcondes
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000469:parasitology*; D004285:Dogs; D005260:Female; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D007674:Kidney Diseases / Q000209:etiology / Q000662:veterinary*; D007896:Leishmaniasis / Q000150:complications / Q000662:veterinary*; D008297:Male; D015995:Prevalence; D011507:Proteinuria / Q000209:etiology / Q000662:veterinary; D012720:Severity of Illness Index