title: Accuracy of administrative claims data to identify dose specific rotavirus vaccination information: Implications for studies of vaccine safety.
abstract: BACKGROUND
  The accuracy of vaccine administration information recorded in administrative claims databases is uncertain.
  
  
  METHODS
  We conducted a retrospective cohort study using the HealthCore Integrated Research Database(SM) among infants who received at least 1 RotaTeq (RV5) dose during the first year of life between February 1, 2006 and November 30, 2012 and were enrolled in the health plan at birth. We reviewed medical records for a sample of infants to validate vaccine administration information.
  
  
  RESULTS
  We identified 169,560 infants who received at least 1 RV5 dose. Medical records were obtained for 85 infants, of which 74 (PPV1 87.1%; 95% CI 78.0-93.4%) had a corresponding first RV5 vaccination in the medical record with the same or similar administration date.
  
  
  CONCLUSIONS
  Administrative claims contained inaccuracies in dose number or administration date for 13% of RV5 first doses identified.
authors.affiliation: HealthCore, Inc., 800 Delaware Avenue, Fifth Floor, Wilmington, DE 19801, United States. Electronic address: squinlan@healthcore.com.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Quinlan
authors.affiliation: HealthCore, Inc., 800 Delaware Avenue, Fifth Floor, Wilmington, DE 19801, United States.
authors.forename: Stephan
authors.initials: S
authors.lastname: Lanes
authors.affiliation: HealthCore, Inc., 800 Delaware Avenue, Fifth Floor, Wilmington, DE 19801, United States.
authors.forename: Crystal N
authors.initials: CN
authors.lastname: Holick
authors.affiliation: Department of Epidemiology, Merck Research Laboratories, 351 N. Sumneytown Pike, North Wales, PA 19454, United States.
authors.forename: T Christopher
authors.initials: TC
authors.lastname: Mast
mesh_terms: D015331:Cohort Studies; D000068598:Data Accuracy; D016208:Databases, Factual / Q000592:standards*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008499:Medical Records / Q000592:standards*; D012189:Retrospective Studies; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D013997:Time Factors; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000008:administration & dosage
chemical_list: C492535:RotaTeq; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated
keywords: Administrative claims; Positive predictive value; Rotavirus vaccination; Safety; Validation