title: Polymorphisms in the inflammatory pathway genes and the risk of preeclampsia in Sinhalese women.
abstract: OBJECTIVE
  Elevated pro-inflammatory cytokines play an important role in the pathogenesis of preeclampsia. We investigated the prevalence of functional polymorphisms in genes regulating inflammation in preeclamptic women.
  
  
  METHODS
  One hundred seventy-five nulliparous Sinhalese women with preeclampsia (cases) and 171 normotensive women matched for age, ethnicity, parity and body mass index (BMI) (controls) were recruited. Preeclampsia was diagnosed using international guidelines. Genotyping was performed on DNA extracted from peripheral blood using the Sequenom MassARRAY system.
  
  
  RESULTS
  The prevalence of the CT genotype of IL1A rs17561 polymorphism was increased in preeclamptic women compared with controls {p = 0.04, odds ratio (OR) [95% class interval (CI)] = 1.6 (1.0-2.5)}. The prevalence of the CT genotype [p = 0.01, OR (95% CI) = 1.8 (1.1-2.8)] and the dominant model (CT + TT) [p = 0.03, OR (95% CI) = 1.6 (1.1-2.5)] of the IL1A rs1800587 polymorphism were increased in preeclamptic women compared with controls. The prevalence of the GA genotype [p = 0.04, OR (95% CI) = 0.6 (0.4-0.9)] and the dominant model (GA + AA) [p = 0.03, OR (95% CI) = 0.6 (0.4-0.9)] of the MBL1 rs1800450 polymorphism were reduced in preeclamptic women compared to controls.
  
  
  CONCLUSIONS
  Genotypes conferring a pro-inflammatory phenotype are increased in preeclamptic women.
authors.affiliation: a Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide , Adelaide , Australia .
authors.forename: Prabha H
authors.initials: PH
authors.lastname: Andraweera
authors.affiliation: a Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide , Adelaide , Australia .|b Women's and Children's Division, Lyell McEwin Hospital , Elizabeth Vale , South Australia , and.
authors.forename: Gustaaf A
authors.initials: GA
authors.lastname: Dekker
authors.affiliation: c Human Genetics Unit, Faculty of Medicine, University of Colombo , Colombo , Sri Lanka.
authors.forename: Rohan W
authors.initials: RW
authors.lastname: Jayasekara
authors.affiliation: c Human Genetics Unit, Faculty of Medicine, University of Colombo , Colombo , Sri Lanka.
authors.forename: Vajira H W
authors.initials: VH
authors.lastname: Dissanayake
authors.affiliation: a Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, Robinson Research Institute, University of Adelaide , Adelaide , Australia .
authors.forename: Claire T
authors.initials: CT
authors.lastname: Roberts
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy; D012307:Risk Factors; D015398:Signal Transduction / Q000235:genetics; D013188:Sri Lanka / Q000208:ethnology; D055815:Young Adult
chemical_list: C508584:IL1A protein, human; D018836:Inflammation Mediators; D053582:Interleukin-1alpha; D037601:Mannose-Binding Lectin
keywords: Inflammation; interleukin; polymorphism; preeclampsia