title: Cyclophilin A is associated with peripheral artery disease and chronic kidney disease in geriatrics: The Tianliao Old People (TOP) study.
abstract: Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population and its association with CyPA and renal function. Residents of Tianliao District, a rural community in southern Taiwan, were surveyed. An ankle-brachial index (ABI) < 0.91 was defined as PAOD. Chronic kidney disease (CKD) was defined based on eGFR levels < 60 mL/min/1.73 m(2). Serum CyPA was measured. Of the 473 participants, 68 (14.4%) had PAOD. Multiple logistic regression analysis showed PAOD was significantly associated with lower eGFR, lower BMI, higher glycated hemoglobin and higher pulse pressure. Serum CyPA levels in participants with PAOD were significantly higher than those with normal ABI values (47.3 ± 0.4 vs. 25.5 ± 0.2 ng/mL, p < 0.001). Moreover, eGFR inversely correlated with serum CyPA level (p < 0.05) in participants with CKD, but not in participants with normal renal function. In conclusion, with a prevalence of PAOD as high as 14.4% in an elderly community, CyPA might be the link between PAOD and advanced impaired renal function.
authors.affiliation: School of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Meng-Chuan
authors.initials: MC
authors.lastname: Liu
authors.affiliation: School of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yen-Wei
authors.initials: YW
authors.lastname: Lee
authors.affiliation: 1] Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan [2] Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Po-Tseng
authors.initials: PT
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Chin-Sung
authors.initials: CS
authors.lastname: Chang
authors.affiliation: 1] Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan [2] Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Tai
authors.affiliation: Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Yu
authors.affiliation: Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Su
authors.affiliation: Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Ling-Wei
authors.initials: LW
authors.lastname: Hsu
authors.affiliation: Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Sheng-Hsiang
authors.initials: SH
authors.lastname: Lin
authors.affiliation: Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Chi-Hsing
authors.initials: CH
authors.lastname: Wu
authors.affiliation: 1] School of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan [2] Division of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan [3] Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Ping-Yen
authors.initials: PY
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D021984:Cyclophilin A / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000378:metabolism / Q000473:pathology*; D051436:Renal Insufficiency, Chronic / Q000378:metabolism / Q000473:pathology*; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking
chemical_list: D015415:Biomarkers; D021984:Cyclophilin A; D006442:Glycated Hemoglobin