title: Identification of cancerous gastric cells based on common features extracted from hyperspectral microscopic images.
abstract: We construct a microscopic hyperspectral imaging system to distinguish between normal and cancerous gastric cells. We study common transmission-spectra features that only emerge when the samples are dyed with hematoxylin and eosin (H&E) stain. Subsequently, we classify the obtained visible-range transmission spectra of the samples into three zones. Distinct features are observed in the spectral responses between the normal and cancerous cell nuclei in each zone, which depend on the pH level of the cell nucleus. Cancerous gastric cells are precisely identified according to these features. The average cancer-cell identification accuracy obtained with a backpropagation algorithm program trained with these features is 95%.
authors.affiliation: Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, Guangzhou, Guangdong 510632, China ; Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
authors.forename: Siqi
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, Guangzhou, Guangdong 510632, China ; Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Su
authors.affiliation: Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, Guangzhou, Guangdong 510632, China ; Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
authors.forename: Yumeng
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, Guangzhou, Guangdong 510632, China ; Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yin
authors.affiliation: Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, Guangzhou, Guangdong 510632, China ; Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.affiliation: Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, Guangzhou, Guangdong 510632, China ; Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
authors.forename: Furong
authors.initials: F
authors.lastname: Huang
authors.affiliation: Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, Guangzhou, Guangdong 510632, China ; Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong 510632, China.
authors.forename: Zhenqiang
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Chen
authors.affiliation: Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, Guangzhou, Guangdong 510632, China ; Department of Optoelectronic Engineering, Jinan University, Guangzhou, Guangdong 510632, China ; Guangzhou Ante Laser Technology Co. Ltd, Guangzhou, Guangdong 510663, China.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Chen
keywords: (110.4234) Multispectral and hyperspectral imaging; (170.0170) Medical optics and biotechnology; (170.6935) Tissue characterization