title: Genetics and hepatitis C: it's good to be 'CC'.
abstract: The interleukin-28B (IL28B) gene contains a single-nucleotide polymorphism at location rs12979860 that affects both the natural history of hepatitis C virus infection and the patient's response to treatment, particularly interferon-based regimens with or without protease inhibitors.
authors.affiliation: Department of Gastroenterology, Providence Hospital and Medical Centers, Southfield, MI, USA.
authors.forename: Jose Mari
authors.initials: JM
authors.lastname: Parungao
authors.affiliation: Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic.|Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Ibrahim A
authors.initials: IA
authors.lastname: Hanouneh
authors.affiliation: Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic.|Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Binu
authors.initials: B
authors.lastname: John
authors.affiliation: Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Naim
authors.initials: N
authors.lastname: Alkhouri
authors.affiliation: Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic.|Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA. E-mail: zeinn@ccf.org.
authors.forename: Nizar N
authors.initials: NN
authors.lastname: Zein
mesh_terms: D004247:DNA / Q000235:genetics*; D005819:Genetic Markers; D019698:Hepatitis C, Chronic / Q000235:genetics / Q000378:metabolism / Q000821:virology; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D000095022:Interferon Lambda
chemical_list: D004247:DNA; D005819:Genetic Markers; D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda