title: Efficacy of statin monotherapy or in combination with coenzyme a capsule in patients with metabolic syndrome and mixed dyslipidemia.
abstract: BACKGROUND
  Patients with metabolic syndrome are at increased risk for cardiovascular disease. Combination lipid-lowering therapy is often needed in patients with metabolic syndrome and mixed dyslipidemia. The aim of this study was to compare the effect of statin combined with a new hypolipidemic agent, coenzyme A (CoA) with moderate-dose statin monotherapy in subjects with metabolic syndrome and mixed dyslipidemia by evaluating data from a subgroup of patients with metabolic syndrome and mixed dyslipidemia from a previously conducted randomized study.
  
  
  METHODS
  In the present post hoc analysis, 212 patients were included, receiving statin monotherapy (n = 94) or statin combined with CoA 400 U/day (n = 118) for 8 weeks. The lipoprotein profile was determined at baseline and week 8 visits. Attainment of low-density lipoprotein-cholesterol (LDL-C) < 100 mg/dL, non-high-density lipoprotein-cholesterol (HDL-C) < 130 mg/dL, and the combined goal of these two parameters was also evaluated.
  
  
  RESULTS
  The mean percent change was more prominent with CoA plus statin compared with placebo plus statin in triglyceride (TG) (-32.5% vs. -8.7%, respectively; P = 0.0002), total cholesterol (-9.6% vs. -3.6%, P = 0.013), LDL-C (-7.5% vs. 2.1%, P = 0.033), and non-HDL-C (-14.3% vs. -6.4%, P = 0.011). Treatment with CoA plus statin resulted in larger percentages of participants attaining lipid goals for LDL-C (70.3% vs. 56.4%, P = 0.044), non-HDL-C (60.2% vs. 45.7%, P = 0.039), and the combined goal of LDL-C and non-HDL-C (57.6% vs. 42.6%, P = 0.038) than statin monotherapy.
  
  
  CONCLUSIONS
  These results demonstrate that CoA plus statin therapy was more effective in improving lipoprotein parameters than statin alone in patients with metabolic syndrome and mixed hyperlipidemia.
authors.affiliation: Department of Cardiology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Lai
authors.affiliation: Department of Cardiology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Bifeng
authors.initials: B
authors.lastname: Wu
authors.affiliation: Department of Cardiology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Tianming
authors.initials: T
authors.lastname: Xuan
authors.affiliation: Department of Cardiology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Shudong
authors.initials: S
authors.lastname: Xia
authors.affiliation: Department of Cardiology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Cardiology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Junzhu
authors.initials: J
authors.lastname: Chen
keywords: Coenzyme A; Combination therapy; Dyslipidemia; Hypertriglyceridemia; Metabolic syndrome