title: Cerebral glucose metabolism in the striate cortex positively correlates with fractional anisotropy values of the optic radiation in patients with glaucoma.
abstract: BACKGROUND
  It has recently become clear that glaucoma is not only an ocular disease, but involves central visual pathways as well. The purpose of this study was to examine functional and structural alterations in the brains of glaucoma patients.
  
  
  METHODS
  Case-control study in a hospital.
  
  
  METHODS
  A total of 32 glaucoma patients and 19 healthy controls.
  
  
  METHODS
  All participants underwent positron emission tomography with (18)F-fluorodeoxyglucose, diffusion-tensor magnetic resonance imaging, and the 30-2 program of the Humphrey Visual Field Analyzer.
  
  
  METHODS
  Fractional anisotropy values of the optic radiation were compared between the two groups by defining regions of interests. Cerebral glucose metabolism was compared using statistical parametric mapping software. The correlation coefficients were calculated between the average of the total deviation of hemivisual fields of both eyes, fractional anisotropy values of the contralateral optic radiation and glucose metabolism in the contralateral striate cortex.
  
  
  RESULTS
  Fractional anisotropy values in the bilateral optic radiations were significantly lower in patients with glaucoma. A significant glucose hypometabolism in the bilateral striate cortex was also observed in the glaucoma group. Regression analyses for glaucoma patients demonstrated that the average of the total deviation of hemivisual fields significantly correlated with both fractional anisotropy value of the contralateral optic radiation and glucose metabolism in the contralateral striate cortex. Moreover, there were significant correlations between fractional anisotropy values of the optic radiation and ipsilateral striatal glucose metabolism.
  
  
  CONCLUSIONS
  We observed structural alterations in the bilateral optic radiations and glucose hypometabolism in the bilateral striate cortex of glaucoma patients.
authors.affiliation: Department of Ophthalmology and Visual Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.|Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Murai
authors.affiliation: Department of Ophthalmology and Visual Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.|Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Ophthalmology and Visual Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.|Kiyosawa Eye Clinic, Tokyo, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Kiyosawa
authors.affiliation: Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan.
authors.forename: Aya M
authors.initials: AM
authors.lastname: Tokumaru
authors.affiliation: Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors.forename: Kiichi
authors.initials: K
authors.lastname: Ishiwata
authors.affiliation: Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016880:Anisotropy; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage; D005901:Glaucoma / Q000000981:diagnostic imaging / Q000378:metabolism*; D044882:Glucose Metabolism Disorders / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000000981:diagnostic imaging / Q000378:metabolism*; D049268:Positron-Emission Tomography; D011446:Prospective Studies; D014786:Vision Disorders / Q000000981:diagnostic imaging / Q000378:metabolism*; D014793:Visual Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D058609:Visual Field Tests; D014794:Visual Fields
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18
keywords: cerebral glucose metabolism; diffusion-tensor magnetic resonance imaging; glaucoma; optic radiation