title: Differential patterns of prenatal ipsilateral and contralateral lung growth in cases of isolated left-sided congenital diaphragmatic hernia.
abstract: OBJECTIVE
  The aim of this research was to compare the impact of varying degrees of visceral herniation on the growth rates of the contralateral and ipsilateral fetal lungs in cases of isolated left-sided congenital diaphragmatic hernia (CDH).
  
  
  METHODS
  Data were retrieved from 58 fetuses with isolated left-sided CDH undergoing magnetic resonance imaging studies at both mid-gestation (20-30 weeks) and late-gestation (>30 weeks) time points. The growth of the right and left lungs (ΔLV-R and ΔLV-L) was calculated. The impact of the degree of visceral herniation on the growth disparity between the right and left lungs was then compared.
  
  
  RESULTS
  Measurable growth occurred in both lungs between the mid-gestation and late-gestation time points in each group. The ΔLV-R exhibited a strong correlation with ΔLV-L. However, the right lung grew significantly faster than the left lung (ΔLV-R = 1.36 vs ΔLV-L = 0.17 mL/week, P < 0.001). A higher degree of visceral herniation appeared to decrease the growth rate disparity by progressive limitation of the growth of the right lung.
  
  
  CONCLUSIONS
  The contralateral lung retains the potential to grow faster than the ipsilateral lung during the third trimester. A higher degree of visceral herniation places progressive limitations on contralateral lung growth thereby diminishing the growth rate disparity between the right and left lungs.
authors.affiliation: Cincinnati Fetal Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
authors.forename: Nisarat
authors.initials: N
authors.lastname: Phithakwatchara
authors.affiliation: Cincinnati Fetal Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Alan
authors.identifier: http://orcid.org/0000-0002-8373-8355
authors.initials: A
authors.lastname: Coleman
authors.affiliation: Cincinnati Fetal Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Jose L
authors.initials: JL
authors.lastname: Peiro
authors.affiliation: Cincinnati Fetal Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Lee
authors.affiliation: Cincinnati Fetal Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Sundeep G
authors.initials: SG
authors.lastname: Keswani
authors.affiliation: Cincinnati Fetal Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Division of Pediatric Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Beth
authors.initials: B
authors.lastname: Kline-Fath
authors.affiliation: Cincinnati Fetal Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Foong-Yen
authors.initials: FY
authors.lastname: Lim
authors.affiliation: Cincinnati Fetal Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Aimen F
authors.initials: AF
authors.lastname: Shaaban
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000196:embryology* / Q000209:etiology; D000328:Adult; D005260:Female; D065630:Hernias, Diaphragmatic, Congenital / Q000150:complications / Q000175:diagnosis / Q000196:embryology*; D006801:Humans; D008137:Longitudinal Studies; D008168:Lung / Q000002:abnormalities* / Q000196:embryology*; D008171:Lung Diseases / Q000175:diagnosis / Q000196:embryology* / Q000209:etiology; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis; D012189:Retrospective Studies