title: Hyper-reactive malarial splenomegaly (HMS) in a patient with β thalassaemia syndrome.
abstract: This report describes a case of hyper-reactive malarial splenomegaly in a patient with a thalassaemia syndrome. Increased haemoglobin A2 is valuable for the diagnosis of common forms of β-thalassemia, while haemoglobin F (HbF) helps in diagnosis of the rarer δβ- forms. Thalassemia is characterised by splenomegaly and is common in malaria endemic areas. Hyper-reactive malarial splenomegaly is also a common cause of massive splenomegaly in malaria endemic areas. Splenic enlargement regresses with prolonged antimalarial therapy.
authors.affiliation: Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
authors.forename: Yaw Ampem
authors.initials: YA
authors.lastname: Amoako
authors.affiliation: Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana ; School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: George
authors.initials: G
authors.lastname: Bedu-Addo
mesh_terms: D000293:Adolescent; D000962:Antimalarials / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008288:Malaria / Q000150:complications* / Q000188:drug therapy; D013163:Splenomegaly / Q000188:drug therapy / Q000469:parasitology*; D017086:beta-Thalassemia / Q000503:physiopathology*
chemical_list: D000962:Antimalarials
keywords: Ghana; Hyper-reactive malarial splenomegaly; Massive splenomegaly; Proguanil; béta thalassemia syndrome