title: Evaluation of serum vitamin B12 levels and its correlation with anti-thyroperoxidase antibody in patients with autoimmune thyroid disorders.
abstract: Vitamin B12 deficiency has been reported in patients with Autoimmune thyroid disorders. However there is limited data on exact prevalence of low B12 and its correlation with anti-thyroperoxidase antibody (anti-TPO) levels in these patients. The aim of our study was to estimate serum vitamin B12 levels in autoimmune thyroid disorders and to correlate B12 levels with anti-TPO. 350 patients were selected by convenient sampling. Vitamin B12 levels and thyroid parameters were estimated using fully automated chemiluminescence method on Access 2. Results of our study shows that using the manufacturer's cut-off of 145 pg/mL, the prevalence of low serum vitamin B12 was found to be 45.50 %. Higher prevalence (55 %) was seen based on the published cut-off of 200 pg/mL The study however did not demonstrate any significant correlation between vitamin B12 levels and anti-TPO (r = -0.11 and p value of 0.30).
authors.affiliation: Department of Biochemistry, St John's Medical College and Hospital, Bangalore, India.
authors.forename: S
authors.initials: S
authors.lastname: Jaya Kumari
authors.affiliation: Department of Endocrinology, St John's Medical College and Hospital, Bangalore, India.
authors.forename: Ganapathy
authors.initials: G
authors.lastname: Bantwal
authors.affiliation: Department of Biochemistry, St John's Medical College and Hospital, Bangalore, India.
authors.forename: Anitha
authors.initials: A
authors.lastname: Devanath
authors.affiliation: Department of Endocrinology, St John's Medical College and Hospital, Bangalore, India.
authors.forename: Vageesh
authors.initials: V
authors.lastname: Aiyyar
authors.affiliation: Department of Endocrinology, St John's Medical College and Hospital, Bangalore, India.
authors.forename: Madhuri
authors.initials: M
authors.lastname: Patil
keywords: Anti-thyroperoxidase (anti-TPO); Auto antibodies; Autoimmune thyroid disorders (AITD); Autoimmunity; Vitamin B12