title: [Plaque-like leiomyomas on a chemical burn: First case report].
abstract: BACKGROUND
  Cutaneous leiomyomas are uncommon benign smooth muscle neoplasms of skin of unknown pathogenesis. We report a sporadic case of multiple cutaneous leiomyomas at the site of a chemical burn.
  
  
  METHODS
  A 47-year-old male presented with multiple grouped red nodules on the right calf painful to cold and to touch. The lesions were located on the site of a chemical wound that had occurred 5 years earlier. Histopathological examination revealed a proliferation of smooth muscle fibres, leading to diagnosis of leiomyoma.
  
  
  CONCLUSIONS
  To our knowledge, the literature contains no previous reports of sporadic multiple cutaneous leiomyomas occurring at a chemical burn site. While a chance association cannot be ruled out, there is also the possibility of a physiopathological mechanism similar to that of vascular tumours following exposure to 4-hydrazinobenzoic acid. This compound, a hydrazine derivative of the fungus Agaricus bisporus, can cause smooth-muscle tumours in the aorta and large vessels with morphological characteristics similar to those seen in vascular leiomyomas.
authors.affiliation: Service de dermatologie, hôpital Nord, chemin des Bourrely, 13015 Marseille, France. Electronic address: ltroin@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Troin
authors.affiliation: Service de dermatologie, hôpital Nord, chemin des Bourrely, 13015 Marseille, France.
authors.forename: D
authors.initials: D
authors.lastname: Brajon
authors.affiliation: Service de dermatologie, hôpital Nord, chemin des Bourrely, 13015 Marseille, France.
authors.forename: E
authors.initials: E
authors.lastname: Combes
authors.affiliation: Service de dermatologie, hôpital Nord, chemin des Bourrely, 13015 Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Horreau
authors.affiliation: Service d'anatomopathologie, hôpital Nord, chemin des Bourrely, 13015 Marseille, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Dales
authors.affiliation: Service de dermatologie, hôpital Nord, chemin des Bourrely, 13015 Marseille, France.
authors.forename: M-C
authors.initials: MC
authors.lastname: Koeppel
authors.affiliation: Service de dermatologie, hôpital Nord, chemin des Bourrely, 13015 Marseille, France.
authors.forename: P
authors.initials: P
authors.lastname: Berbis
mesh_terms: D019342:Acetic Acid; D002057:Burns, Chemical / Q000150:complications* / Q000503:physiopathology; D002471:Cell Transformation, Neoplastic; D006201:Hair Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D018859:Hair Follicle / Q000473:pathology*; D006801:Humans; D006858:Hydrofluoric Acid; D007249:Inflammation; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D007869:Leg Injuries / Q000150:complications* / Q000503:physiopathology; D007889:Leiomyoma / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D017942:Nitric Acid; D060051:Occupational Injuries / Q000150:complications* / Q000503:physiopathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D014945:Wound Healing
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D017942:Nitric Acid; D019342:Acetic Acid; D006858:Hydrofluoric Acid
keywords: Brûlure chimique; Chemical burn; Cutaneous leiomyomas; Léiomyomes cutanés; Trauma; Traumatisme