title: Cytochalasin derivatives from a jellyfish-derived fungus Phoma sp.
abstract: Four new cytochalasin derivatives (1-4), together with proxiphomin (5), were isolated from a jellyfish-derived fungus Phoma sp. The planar structures and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed moderate cytotoxicity against a small panel of human solid tumor cell lines (A549, KB, and HCT116).
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Eun La
authors.initials: EL
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Ju Hee
authors.initials: JH
authors.lastname: Park
authors.affiliation: College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.affiliation: Department of Food Science and Nutrition, Pukyong National University, Busan 608-737, Republic of Korea.
authors.forename: Jae Sue
authors.initials: JS
authors.lastname: Choi
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Dong Soon
authors.initials: DS
authors.lastname: Im
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Chung
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: jhjung@pusan.ac.kr.
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification*; D005658:Fungi / Q000737:chemistry*; D015394:Molecular Structure; D037401:Scyphozoa / Q000382:microbiology*; D013237:Stereoisomerism
chemical_list: D003572:Cytochalasins
keywords: Cytochalasin; Cytotoxicity; Jellyfish-derived fungus; Nemopilema nomurai; Phoma sp.