title: Synthesis and cytotoxicity of longistylin C derivatives.
abstract: The present study was designed to identify potent anti-tumor compounds from a series of new longistylin C derivatives. Ten longistylin C derivatives were synthesized and their structures were confirmed by (1)H NMR, MS, and elemental analyses. Their cytotoxicity in vitro against three human cancer cell lines (A549, HepG2, and MCF-7) were evaluated by the MTT assay. Among these compounds, DT-6 and DT-9 displayed much better cytotoxicity against A549, HepG2, and MCF-7 cells, DT-1 exhibited selective cytotoxicity against HepG2, and the structure-activity relationships were investigated. In conclusion, Compounds DT-6 and DT-9 may serve as potential lead compounds for the discovery of new anti-cancer drugs.
authors.affiliation: Sino-German Joint Research Institute, Nanchang University, Nanchang 330047, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Shan
authors.affiliation: Sino-German Joint Research Institute, Nanchang University, Nanchang 330047, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Hong
authors.affiliation: Sino-German Joint Research Institute, Nanchang University, Nanchang 330047, China.
authors.forename: Yan-Fei
authors.initials: YF
authors.lastname: Wang
authors.affiliation: South China Botanical Garden, the Chinese Academy of Science, Guangzhou 510560, China.
authors.forename: Nen-Ling
authors.initials: NL
authors.lastname: Zhang
authors.affiliation: Sino-German Joint Research Institute, Nanchang University, Nanchang 330047, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.affiliation: Sino-German Joint Research Institute, Nanchang University, Nanchang 330047, China. Electronic address: luyzsu@hotmail.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lu
authors.affiliation: South China Botanical Garden, the Chinese Academy of Science, Guangzhou 510560, China. Electronic address: sxqiu@scbg.ac.cn.
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Qiu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents
keywords: Cytotoxicity; LongistylinC derivatives; Synthesis