title: Salivary biomarkers of oxidative stress: A critical review.
abstract: Human saliva is an increasingly attractive medium for biomarker discovery due to its amenability to noninvasive and repeated sampling, ease of collection and processing, and suitability for single analyte or metabolomic measurements. Salivary biomarkers of oxidative stress reflect local and systemic pathologies and may inform on the diagnosis, prognosis, and therapeutic responsiveness of numerous human diseases. However, for many of the disorders investigated, data reporting on alterations in salivary redox homeostasis are often highly conflicted across studies. We surveyed the available biomedical literature on this topic and noted significant discrepancies in the study designs, target populations, and operating procedures which likely contribute to the discordant data sets reported. Based on these observations, guidelines are provided to minimize interlaboratory variability in redox biomarker discovery based on human saliva.
authors.affiliation: Department of Dentistry, Jewish General Hospital, 3755 Cote-Ste-Catherine, A-024, Montreal, Quebec H3T1E2, Canada; Lady Davis Institute for Medical Research, 3755 Cote-Ste-Catherine, Montreal, QC, Canada.
authors.forename: Jessica
authors.initials: J
authors.lastname: Wang
authors.affiliation: Lady Davis Institute for Medical Research, 3755 Cote-Ste-Catherine, Montreal, QC, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
authors.forename: Hyman M
authors.initials: HM
authors.lastname: Schipper
authors.affiliation: Department of Dentistry, Jewish General Hospital, 3755 Cote-Ste-Catherine, A-024, Montreal, Quebec H3T1E2, Canada; Lady Davis Institute for Medical Research, 3755 Cote-Ste-Catherine, Montreal, QC, Canada; Centre for Clinical Epidemiology and Community Studies, 3755 Cote-Ste-Catherine, Montreal, QC, Canada; Faculty of Dentistry, McGill University, 2001 McGill College Avenue, Suite 500, Montreal, Quebec H3A 1G1.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Velly
authors.affiliation: Department of Dentistry, Jewish General Hospital, 3755 Cote-Ste-Catherine, A-024, Montreal, Quebec H3T1E2, Canada; Lady Davis Institute for Medical Research, 3755 Cote-Ste-Catherine, Montreal, QC, Canada.
authors.forename: Shrisha
authors.initials: S
authors.lastname: Mohit
authors.affiliation: Department of Dentistry, Jewish General Hospital, 3755 Cote-Ste-Catherine, A-024, Montreal, Quebec H3T1E2, Canada; Lady Davis Institute for Medical Research, 3755 Cote-Ste-Catherine, Montreal, QC, Canada; Faculty of Dentistry, McGill University, 2001 McGill College Avenue, Suite 500, Montreal, Quebec H3A 1G1. Electronic address: mgornits@jgh.mcgill.ca.
authors.forename: Mervyn
authors.initials: M
authors.lastname: Gornitsky
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D004194:Disease / Q000145:classification; D006801:Humans; D018384:Oxidative Stress; D012463:Saliva / Q000378:metabolism*
chemical_list: D015415:Biomarkers
keywords: Biomarker; Diagnosis; Guidelines; Oxidative stress; Saliva