title: Improved prophylaxis of postoperative nausea vomiting: Palonosetron a novel antiemetic.
abstract: Many anti-emetics are used in clinical practice. Palonosetron hydrochloride is one of them. It is a novel, centrally acting antiemetic, and anti-nausea agent. This drug is an antagonist of serotonin receptor subtype 3 (5-HT3). This drug has longer duration of action which makes it useful in the prevention and treatment of acute and delayed onset of nausea and vomiting. This drug was initially used for chemotherapy induced nausea and vomiting. Federal drug agency (FDA) has approved it for prevention and treatment of post-operative nausea and vomiting. The literature search for this article was done using Google scholar and Pubmed using the terms "Palonosetron," "longer duration of action," "nausea," "vomiting," and "postoperative".
authors.affiliation: Department of Anaesthesiology and Critical Care, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.
authors.forename: Akshaya N
authors.initials: AN
authors.lastname: Shetti
authors.affiliation: Department of Anaesthesiology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.
authors.forename: Dewan Roshan
authors.initials: DR
authors.lastname: Singh
authors.affiliation: Department of Anaesthesiology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.
authors.forename: Kusha
authors.initials: K
authors.lastname: Nag
authors.affiliation: Department of Paedodontics and Preventive Dentistry, School of Dental Sciences, Karad, Maharashtra, India.
authors.forename: Rachita A
authors.initials: RA
authors.lastname: Shetti
authors.affiliation: Department of Anaesthesiology, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India.
authors.forename: V R Hemanth
authors.initials: VR
authors.lastname: Kumar
keywords: 5-HT3; Antiemetics; anesthesia; nausea; palonosetron; post-operative; vomiting