title: Extracellular matrix-inspired growth factor delivery systems for bone regeneration.
abstract: Growth factors are very promising molecules to enhance bone regeneration. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems derive from the vastly supra-physiological doses of growth factor used without optimized delivery systems. Therefore, these issues have motivated the development of new delivery systems allowing better control of the spatiotemporal release and signaling of growth factors. Because the extracellular matrix (ECM) naturally plays a fundamental role in coordinating growth factor activity in vivo, a number of novel delivery systems have been inspired by the growth factor regulatory function of the ECM. After introducing the role of growth factors during the bone regeneration process, this review exposes different issues that growth factor-based therapies have encountered in the clinic and highlights recent delivery approaches based on the natural interaction between growth factor and the ECM.
authors.affiliation: Immunology Frontier Research Center, Osaka University, Osaka, Japan. Electronic address: mmartino@ifrec.osaka-u.ac.jp.
authors.forename: Mikaël M
authors.initials: MM
authors.lastname: Martino
authors.affiliation: Institute of Bioengineering, School of Life Sciences and School of Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
authors.forename: Priscilla S
authors.initials: PS
authors.lastname: Briquez
authors.affiliation: Immunology Frontier Research Center, Osaka University, Osaka, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Maruyama
authors.affiliation: Institute of Bioengineering, School of Life Sciences and School of Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Institute for Molecular Engineering, University of Chicago, Chicago, IL, USA; Materials Science Division, Argonne National Laboratory, Argonne, IL, USA. Electronic address: jhubbell@uchicago.edu.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Hubbell
mesh_terms: D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D001861:Bone Regeneration / Q000502:physiology*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D005109:Extracellular Matrix / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D016023:Integrins / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage / Q000494:pharmacology; D042461:Vascular Endothelial Growth Factor A / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D019485:Bone Morphogenetic Proteins; D003692:Delayed-Action Preparations; D016023:Integrins; D036341:Intercellular Signaling Peptides and Proteins; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors
keywords: Bone morphogenetic protein; Clinical translation; Controlled delivery; Extracellular matrix; Fibroblast growth factor; Integrins; Platelet-derived growth factor; Vascular endothelial growth factor