title: Therapeutic effect of Agaricus brasiliensis on phenylhydrazine-induced neonatal jaundice in rats.
abstract: The present study was designed to investigate the effect of Agaricus brasiliensis extract (ABE) on phenylhydrazine-induced neonatal jaundice in rats. Administration of ABE dose-dependently reduced the elevated bilirubin level induced by phenylhydrazine. It can be somewhat supported from the results of in vitro bilirubin degradation experiment. ABE treatment also reduced the total antioxidant status (TAOS), cascade O2(-)/SOD, level of NF-κB protein, and adrenomedullin (AM). Overall, the results of this study demonstrated that Agaricus brasiliensis extract may be beneficial to reducing bilirubin level without causing hepatotoxicity in neonatal jaundice.
authors.affiliation: Department of Pediatrics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Xi'an Central Hospital, Xi'an 710003, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yuan
authors.affiliation: Department of Pediatrics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: HuiPing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Gao
mesh_terms: D053607:Adrenomedullin / Q000378:metabolism; D000364:Agaricus; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D045424:Complex Mixtures / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D007567:Jaundice, Neonatal / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D010659:Phenylhydrazines / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D045424:Complex Mixtures; D016328:NF-kappa B; D010659:Phenylhydrazines; C030299:phenylhydrazine; D013481:Superoxides; D053607:Adrenomedullin; D013482:Superoxide Dismutase