title: Tertiary amides of Salinomycin: A new group of antibacterial agents against Bacillus anthracis and methicillin-resistant Staphylococcus epidermidis.
abstract: For the first time, a series of tertiary amides of polyether antibiotic-Salinomycin have been obtained and screened for their antibacterial activity against different strains of bacteria, including Bacillus anthracis and clinical methicillin-resistant Staphylococcus epidermidis (MRSE). Moreover, biofilm inhibition of MRSE and genotoxicity tests against Bacillus subtilis have been performed. Our studies show that Salinomycin and its some derivatives are active against tested bacteria and exhibited definitely bacteriostatic, not bactericidal activity.
authors.affiliation: Medical University of Warsaw, Department of Pharmaceutical Microbiology, Oczki 3, 02-007 Warsaw, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Stefańska
authors.affiliation: Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Poznań, Poland. Electronic address: michant@amu.edu.pl.
authors.forename: Michał
authors.initials: M
authors.lastname: Antoszczak
authors.affiliation: Medical University of Warsaw, Department of Pharmaceutical Microbiology, Oczki 3, 02-007 Warsaw, Poland.
authors.forename: Karolina
authors.initials: K
authors.lastname: Stępień
authors.affiliation: Biological Threats Identification and Countermeasure Center, Military Institute of Hygiene and Epidemiology, Lubelska 2, 24-100 Puławy, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Bartoszcze
authors.affiliation: Biological Threats Identification and Countermeasure Center, Military Institute of Hygiene and Epidemiology, Lubelska 2, 24-100 Puławy, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Mirski
authors.affiliation: Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Poznań, Poland.
authors.forename: Adam
authors.initials: A
authors.lastname: Huczyński
mesh_terms: D000577:Amides / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001408:Bacillus anthracis / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects; D024881:Drug Resistance, Bacterial; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology*; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D000095662:Polyether Polyketides
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides
keywords: Anti-B. anthracis activity; Biofilm inhibition; Genotoxic activity; Ionophores; Salinomycin derivatives