title: Calcium phosphate scaffolds combined with bone morphogenetic proteins or mesenchymal stem cells in bone tissue engineering.
abstract: OBJECTIVE
  The purpose of this study was to review the current status of calcium phosphate (CaP) scaffolds combined with bone morphogenetic proteins (BMPs) or mesenchymal stem cells (MSCs) in the field of bone tissue engineering (BTE).
  
  
  METHODS
  Data cited in this review were obtained primarily from PubMed and Medline in publications from 1979 to 2014, with highly regarded older publications also included. The terms BTE, CaP, BMPs, and MSC were used for the literature search.
  
  
  METHODS
  Reviews focused on relevant aspects and original articles reporting in vitro and/or in vivo results concerning the efficiency of CaP/BMPs or CaP/MSCs composites were retrieved, reviewed, analyzed, and summarized.
  
  
  RESULTS
  An ideal BTE product contains three elements: Scaffold, growth factors, and stem cells. CaP-based scaffolds are popular because of their outstanding biocompatibility, bioactivity, and osteoconductivity. However, they lack stiffness and osteoinductivity. To solve this problem, composite scaffolds of CaP with BMPs have been developed. New bone formation by CaP/BMP composites can reach levels similar to those of autografts. CaP scaffolds are compatible with MSCs and CaP/MSC composites exhibit excellent osteogenesis and stiffness. In addition, a CaP/MSC/BMP scaffold can repair bone defects more effectively than an autograft.
  
  
  CONCLUSIONS
  Novel BTE products possess remarkable osteoconduction and osteoinduction capacities, and exhibit balanced degradation with osteogenesis. Further work should yield safe, viable, and efficient materials for the repair of bone lesions.
authors.forename: Han
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of Orthopedics, First Affiliated Hospital of Soochow University, Jiangsu 215006, China.
authors.forename: Hui-Lin
authors.initials: HL
authors.lastname: Yang
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000737:chemistry*; D001842:Bone and Bones / Q000166:cytology; D002130:Calcium Phosphates / Q000737:chemistry*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D019485:Bone Morphogenetic Proteins; D002130:Calcium Phosphates; C020243:calcium phosphate