title: A platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics for drug activation monitoring and combinatorial photodynamic-chemotherapy against cisplatin resistant cancer cells.
abstract: A targeted and image-guided platinum prodrug conjugated with a photosensitizer with aggregation-induced emission (AIE) characteristics was designed for real-time and in situ drug activation monitoring in cancer cells as well as combinational photodynamic-chemotherapy against cisplatin resistant cancer cells.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore117585. cheliub@nus.edu.sg.
authors.forename: Youyong
authors.initials: Y
authors.lastname: Yuan
authors.forename: Chong-Jing
authors.initials: CJ
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D057809:HEK293 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000494:pharmacology*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D009944:Organoplatinum Compounds; D017319:Photosensitizing Agents; D011355:Prodrugs; D002945:Cisplatin