title: Prognosis of atypical teratoid rhabdoid tumors (AT/RT) treated with multimodal therapy protocols. Report of our series.
abstract: OBJECTIVE
  Atypical teratoid rhabdoid tumors (AT/RT) of the central nervous system are rare, very aggressive embryological tumors, typically diagnosed in young patients and having a low survival rate after diagnosis. The aim of this study was to emphasize, based on the latest results in the literature, the need for protocols for multidisciplinary treatment in these patients.
  
  
  METHODS
  We report our series of 3 cases treated, diagnosed and followed up between 2009 and 2014. They were treated with multimodal therapy protocols (Rhabdoid SIOP-2007 and European Rhabdoid Registry EU-RHAB-2010). In addition, we carried out a literature review.
  
  
  RESULTS
  Two of our 3 cases (supratentorial and spinal tumors) did not show any progression of the disease after long follow-up, in contrast with most of the cases available in the literature. The second patient had a shorter survival.
  
  
  CONCLUSIONS
  Patient age at the time of diagnosis, supratentorial location of the mass and fewer complications with adjuvant treatments seem to be factors yielding good prognosis for AT/RT tumors. In agreement with the latest international protocols, multidisciplinary treatment is the ideal treatment, consisting of radiotherapy and chemotherapy after complete tumor resection.
authors.affiliation: Neurosurgery Department, Gómez Ulla Hospital, Madrid, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Valencia-Moya
authors.affiliation: Neurosurgery Department, Carlos Haya University Hospital, Málaga, Spain. Electronic address: gonzalezgarcialaura@hotmail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: González-García
authors.affiliation: Neurosurgery Department, Carlos Haya University Hospital, Málaga, Spain.
authors.forename: Bienvenido
authors.initials: B
authors.lastname: Ros-López
authors.affiliation: Oncology Department, Carlos Haya University Hospital, Málaga, Spain.
authors.forename: Tomás
authors.initials: T
authors.lastname: Acha-García
authors.affiliation: Pathology Department, Carlos Haya University Hospital, Málaga, Spain.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Weil-Lara
authors.affiliation: Oncology Department, Carlos Haya University Hospital, Málaga, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Obando-Pacheco
authors.affiliation: Neurosurgery Department, Carlos Haya University Hospital, Málaga, Spain.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Arráez-Sánchez
mesh_terms: D016543:Central Nervous System Neoplasms / Q000628:therapy*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D011379:Prognosis; D018335:Rhabdoid Tumor / Q000628:therapy*; D013724:Teratoma / Q000628:therapy*
keywords: AT/RT; Atypical teratoid rhabdoid tumor; Brain tumor; Multidisciplinary treatment; Pacientes pediátricos; Pediatric patients; TT/RA; Tratamiento multidisciplinar; Tumor cerebral; Tumor teratoide rabdoide atípico