title: Access to Substituted Dihydrothiopyrano[2,3-b]indoles via Sequential Rearrangements During S-Alkylation and Au-Catalyzed Hydroarylation on Indoline-2-thiones.
abstract: An efficient methodology for the synthesis of indole-fused dihydrothiopyrans has been developed from indoline-2-thiones. The protocol involves the synthesis of conjugated ene-yne-substituted indole-sulfides, a gold(III)-catalyzed rearrangement of the ene-yne side chain followed by intramolecular hydroarylation via C3-H functionalization of the indole core. This new synthesis of functionalized tricyclic indole derivatives through sequential rearrangements is quite general in nature.
authors.affiliation: †Department of Biology and Chemistry, Nipissing University, North Bay, ON P1B 8L7, Canada.
authors.forename: Mukund
authors.initials: M
authors.lastname: Jha
authors.affiliation: †Department of Biology and Chemistry, Nipissing University, North Bay, ON P1B 8L7, Canada.|‡Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India.
authors.forename: Ganesh M
authors.initials: GM
authors.lastname: Shelke
authors.affiliation: §Department of Chemistry, Dalhousie University, Halifax, NS B3H 4J3, Canada.
authors.forename: T Stanley
authors.initials: TS
authors.lastname: Cameron
authors.affiliation: ‡Department of Chemistry, Birla Institute of Technology and Science, Pilani, Rajasthan 333031, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar