title: The role of chemokines in adjusting the balance between CD4+ effector T cell subsets and FOXp3-negative regulatory T cells.
abstract: Chemokines are small (~8-14 kDa) structurally-related chemotactic cytokines that regulate cell trafficking through interactions with specific seven-trans membrane, G protein-coupled receptors (GPCRs). One of the important features of G protein-coupled receptors (GPCRs) is their ability to transmit diverse signaling cascades upon binding different ligands. The current review focuses on the interplay between three ligands: CXCL9, CXCL10 and CXCL11 binding the same receptor (CXCR3) on CD4+ T cells, yet direct different signaling cascades to shape T cell mediated immunity. The review brings about a new concept regarding the biological activities of chemokines in shaping CD4+ T cell immunity, and also a new approach for applying chemokine based therapy of autoimmune diseases.
authors.affiliation: Department of Immunology & Rappaport Family Institute for Research in the Medical Sciences Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 1 Efron St., P.O.B. 9649, Bat-Galim, Haifa 32000, Israel. Electronic address: nkarin10@gmail.com.
authors.forename: Nathan
authors.initials: N
authors.lastname: Karin
authors.affiliation: Department of Immunology & Rappaport Family Institute for Research in the Medical Sciences Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 1 Efron St., P.O.B. 9649, Bat-Galim, Haifa 32000, Israel.
authors.forename: Gizi
authors.initials: G
authors.lastname: Wildbaum
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors
keywords: CXCL10; CXCL11; CXCR3; Chemokines; Cytokines; EAE; T cell subsets