title: Primary intracranial angiomatoid fibrous histiocytoma presenting with anaemia and migraine-like headaches and aura as early clinical features.
abstract: A 17-year-old female with migraine with aura complained of fatigue and was diagnosed with anemia. Three years later, changes in her headache pattern prompted hospital referral. Brain MRI showed a bi-lobed extra-axial intracerebral tumor encroaching both parieto-occipital regions. The resection specimen yielded a rare diagnosis of primary intracranial angiomatoid fibrous histiocytoma (AFH). Tumor removal resulted in cessation of her migraine and anemia. AFH may cause systemic symptoms--in this case fatigue and anemia--long before focal neurological symptoms are present. This is the first report of an intracranial AFH presenting as migraine with visual aura and anemia.
authors.affiliation: Danish Headache Centre, Department of Neurology, Rigshospitalet, Glostrup, Faculty of Health Sciences University of Copenhagen, Denmark Department of Neurosurgery, Rigshospitalet, Faculty of Health Sciences University of Copenhagen, Denmark jmh@dadlnet.dk.
authors.forename: Jakob Møller
authors.initials: JM
authors.lastname: Hansen
authors.affiliation: Department of Neuro-Radiology, Rigshospitalet, Faculty of Health Sciences University of Copenhagen, Denmark.
authors.forename: Vibeke Andrée
authors.initials: VA
authors.lastname: Larsen
authors.affiliation: Department of Neuro-pathology, Rigshospitalet, Faculty of Health Sciences University of Copenhagen, Denmark.
authors.forename: David
authors.initials: D
authors.lastname: Scheie
authors.affiliation: Departments of Pathology and Neurological Surgery, University of California San Francisco (UCSF), USA.
authors.forename: Arie
authors.initials: A
authors.lastname: Perry
authors.affiliation: Department of Neurosurgery, Rigshospitalet, Faculty of Health Sciences University of Copenhagen, Denmark.
authors.forename: Jane
authors.initials: J
authors.lastname: Skjøth-Rasmussen
mesh_terms: D000293:Adolescent; D000740:Anemia / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D020325:Migraine with Aura / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery
keywords: Angiomatoid fibrous histiocytoma; migraine; migraine aura; rare tumor