title: Persistent Bordetella bronchiseptica infection in a child with cystic fibrosis: Relationship to bacterial phenotype.
abstract: Bordetella bronchiseptica is an opportunistic bacteria infecting the respiratory tract of patients with cystic fibrosis. We present a case of B. bronchiseptica chronic pulmonary infection and documentation of some phenotypic attributes of the clinical isolates allowing the microorganism to induce progressive respiratory degradation and chronic sputum colonization. We recommend implementing adequate treatment aiming eradication from the first isolation of this bacterium. We advise for practices that minimize opportunities for zoonotic transmission of B. bronchiseptica from family pets.
authors.affiliation: Centre de Ressources et de Compétences de la Mucoviscidose, Service de Pneumologie et d'allergologie de l'Enfant, Hôpital Necker-Enfants malades, Paris, France.
authors.forename: Nevine
authors.initials: N
authors.lastname: El Khatib
authors.affiliation: Laboratoire de Microbiologie, Hôpital Necker-Enfants malades, Paris, France.
authors.forename: Agnes
authors.initials: A
authors.lastname: Ferroni
authors.affiliation: Centre de Ressources et de Compétences de la Mucoviscidose, Service de Pneumologie et d'allergologie de l'Enfant, Hôpital Necker-Enfants malades, Paris, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: Le Bourgeois
authors.affiliation: Centre de Ressources et de Compétences de la Mucoviscidose, Service de Pneumologie et d'allergologie de l'Enfant, Hôpital Necker-Enfants malades, Paris, France.
authors.forename: Frederique
authors.initials: F
authors.lastname: Chedevergne
authors.affiliation: Centre de Ressources et de Compétences de la Mucoviscidose, Service de Pneumologie et d'allergologie de l'Enfant, Hôpital Necker-Enfants malades, Paris, France.
authors.forename: Marlene
authors.initials: M
authors.lastname: Clairicia
authors.affiliation: Centre de Ressources et de Compétences de la Mucoviscidose, Service de Pneumologie et d'allergologie de l'Enfant, Hôpital Necker-Enfants malades, Paris, France.
authors.forename: Helene
authors.initials: H
authors.lastname: Avril
authors.affiliation: National Centre of Reference of Pertussis and other Bordetelloses, Institut Pasteur., Paris, France.
authors.forename: Nicole
authors.initials: N
authors.lastname: Guiso
authors.affiliation: Centre de Ressources et de Compétences de la Mucoviscidose, Service de Pneumologie et d'allergologie de l'Enfant, Hôpital Necker-Enfants malades, Paris, France; Université Paris-Sorbonne, Paris, France; INSERM U 1151, Paris, France. Electronic address: isabelle.sermet@nck.aphp.fr.
authors.forename: I
authors.initials: I
authors.lastname: Sermet-Gaudelus
mesh_terms: D015153:Blotting, Western; D001885:Bordetella Infections / Q000175:diagnosis / Q000382:microbiology*; D016950:Bordetella bronchiseptica / Q000235:genetics / Q000302:isolation & purification*; D002648:Child; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000382:microbiology*; D004269:DNA, Bacterial / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010641:Phenotype; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000382:microbiology*; D013183:Sputum / Q000382:microbiology*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D004269:DNA, Bacterial
keywords: Bordetella bronchiseptica; Chronic infection; Cystic fibrosis