title: Acute lymphoblastic leukemia in a 2-year-old girl whose mother was previously diagnosed with antiphospholipid syndrome: a case report.
abstract: BACKGROUND
  The role of maternal exposures and conditions in the origin of childhood cancer has been a subject of growing interest, but current evidence is inconclusive.
  
  
  METHODS
  We present a case detected in a multicenter case-control study evaluating the association between parental risk factors and childhood acute lymphoblastic leukemia (ALL). The patient is a Colombian girl who was diagnosed with ALL-L1 when she was 2 years old. Her mother had been diagnosed with antiphospholipid syndrome before pregnancy and had also been treated with subcutaneous injections of heparin. Other potentially relevant maternal and patient exposures are also reported in this paper.
  
  
  CONCLUSIONS
  We hypothesize that the maternal autoimmune disease could be a contributor in the causality network of the daughter's leukemia. However, the role of other exposures cannot be excluded.
authors.affiliation: Grupo Colombiano de Estudios Alfa en Epidemiología, Salud Poblacional, Estadística Aplicada y Ciencias Aliadas. Magna Science Corporation, Bogotá, D.C., Colombia. mcastro2505@yahoo.es.|Grupo de Investigación Epidemiológica del Cáncer, Instituto Nacional de Cancerología, Avenida Calle 1 No. 9-85, Bogotá, D.C., Colombia. mcastro2505@yahoo.es.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Castro-Jiménez
authors.affiliation: Postgrado en Salud Ocupacional. Universidad El Bosque, Avenida Carrera 9 No. 131 A - 02, Edificio Fundadores, Bogotá, D.C., Colombia. cefcortes@gmail.com.
authors.forename: Carlos Efraín
authors.initials: CE
authors.lastname: Cortés-Sánchez
authors.affiliation: Departamento de Pediatría, Facultad de Salud. Universidad Industrial de Santander - Hospital Universitario de Santander, Carrera 33 No. 20-126., Bucaramanga, (Santander), Colombia. ruedaernesto34@gmail.com.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Rueda-Arenas
authors.affiliation: Grupo Colombiano de Estudios Alfa en Epidemiología, Salud Poblacional, Estadística Aplicada y Ciencias Aliadas. Magna Science Corporation, Bogotá, D.C., Colombia. lucytiba@yahoo.com.
authors.forename: Lucy Adela
authors.initials: LA
authors.lastname: Tibaduiza-Buitrago
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D002675:Child, Preschool; D000068456:Clinical Studies as Topic; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D018811:Maternal Exposure / Q000009:adverse effects; D009035:Mothers; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D011247:Pregnancy; D012307:Risk Factors
chemical_list: D000925:Anticoagulants; D006493:Heparin