title: Molecular Targets of Omega-3 Fatty Acids for Cancer Therapy.
abstract: Nowadays, dietary guidelines acknowledge the therapeutic role of omega-3 polyunsaturated fatty acids, as the most important class of fatty acids, against different human diseases. During the last two decades, the average level of consumption of omega-3 polyunsaturated fatty acids has increased from 0.1 to 0.2 g per day. Omega-3 polyunsaturated fatty acids are a group of long-chain polyunsaturated fatty acids which are identified in different foods such as fatty fish, shellfish, and vegetable oils. A growing body of epidemiological and experimental evidence supports the anticancer effects of omega-3 polyunsaturated fatty acids, which led to the identification of their molecular targets in several cancer models. The present review focuses on the basic evidence supporting the potential applications of omega-3 polyunsaturated fatty acids in cancer therapy.
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi-630 004, Tamil Nadu, India. devikasi@yahoo.com.
authors.forename: K Pandima
authors.initials: KP
authors.lastname: Devi
authors.forename: T
authors.initials: T
authors.lastname: Rajavel
authors.forename: G L
authors.initials: GL
authors.lastname: Russo
authors.forename: M
authors.initials: M
authors.lastname: Daglia
authors.forename: S F
authors.initials: SF
authors.lastname: Nabavi
authors.affiliation: Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487, Iran. Nabavi208@gmail.com.
authors.forename: S M
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D014157:Transcription Factors / Q000037:antagonists & inhibitors
chemical_list: D016588:Anticarcinogenic Agents; D000970:Antineoplastic Agents; D015525:Fatty Acids, Omega-3; D014157:Transcription Factors