title: [Information processing and brain metabolic characteristics in patients at ultra-high risk for endogenous psychosis].
abstract: OBJECTIVE
  Functional and structural brain abnormalities in people at high risk for psychosis is a subject of intensive studies in biological psychiatry over the last decades. We studied correlations between neurophysiological and neuroimaging parameters in ultra-high risk patients.
  
  
  METHODS
  Fifty-six patients, aged 17-25 years, with nonpsychotic mental disorders were examined. The control group included 30 age- and sex-matched healthy people. Neurophysiological study measured sensory gating. Proton MR-spectroscopy was used to study metabolic processes in the brain (index for glutamate/glutamine, N-acetylaspartate and choline containing compounds in the dorsolateral prefrontal cortex and thalamus of both hemispheres as well as in the genu and splenium of the corpus callosum).
  
  
  CONCLUSIONS
  We found the abnormality of sensory gating in patients at ultra-high risk for endogenous psychosis that was not correlated with the metabolic parameters. The latter were normal or were normalized during treatment.
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: M V
authors.initials: MV
authors.lastname: Shendyapina
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: M A
authors.initials: MA
authors.lastname: Omelchenko
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: I S
authors.initials: IS
authors.lastname: Lebedeva
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: P S
authors.initials: PS
authors.lastname: Kanonovich
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: N A
authors.initials: NA
authors.lastname: Semenova
authors.affiliation: NII INDKhiT DZ of Moscow, Moscow.
authors.forename: M V
authors.initials: MV
authors.lastname: Ublinsky
authors.affiliation: NII INDKhiT DZ of Moscow, Moscow.
authors.forename: D M
authors.initials: DM
authors.lastname: Dmitrienko
authors.affiliation: NII INDKhiT DZ of Moscow, Moscow.
authors.forename: T A
authors.initials: TA
authors.lastname: Akhadov
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: O A
authors.initials: OA
authors.lastname: Simonova
authors.affiliation: Mental Health Research Center, Moscow.
authors.forename: V G
authors.initials: VG
authors.lastname: Kaleda
mesh_terms: D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D002794:Choline / Q000378:metabolism; D005071:Evoked Potentials; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D008297:Male; D008606:Mental Processes; D059906:Neuroimaging; D066244:Proton Magnetic Resonance Spectroscopy; D011618:Psychotic Disorders / Q000453:epidemiology*; D012306:Risk; D013788:Thalamus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult
chemical_list: D005973:Glutamine; D001224:Aspartic Acid; D018698:Glutamic Acid; C000179:N-acetylaspartate; D002794:Choline