title: Global feasibility assessment of interrupting the transmission of soil-transmitted helminths: a statistical modelling study.
abstract: BACKGROUND
  Emphasis is being given to the control of neglected tropical diseases, including the possibility of interrupting the transmission of soil-transmitted helminths (STH). We evaluated the feasibility by country of achieving interruption of the transmission of STH.
  
  
  METHODS
  Based on a conceptual framework for the identification of the characteristics of a successful STH control programme, we assembled spatial data for a range of epidemiological, institutional, economic, and political factors. Using four different statistical methods, we developed a composite score of the feasibility of interrupting STH transmission and undertook a sensitivity analysis of the data and methods.
  
  
  RESULTS
  The most important determining factors in the analysis were underlying intensity of STH transmission, current implementation of control programmes for neglected tropical diseases, and whether countries receive large-scale external funding and have strong health systems. The composite scores suggested that interrupting STH transmission is most feasible in countries in the Americas and parts of Asia (eg, Argentina [range of composite feasibility scores, depending on scoring method, 9·4-10·0], Brazil [8·7- 9·7], Chile [8·84-10·0], and Thailand [9·1-10·0]; there was perfect agreement between the four methods), and least feasible in countries in sub-Saharan Africa (eg, Congo [0·4-2·7] and Guinea [2·0-5·6]; there was full agreement between methods), but there were important exceptions to these trends (eg, Ghana [7·4-10·0]; there was agreement between three methods). Agreement was highest between the scores derived with the expert opinion and principal component analysis weighting schemes (Pearson correlation coefficient, r=0·98). The largest disagreement was between benefit-of-the-doubt-derived and principal-component-analysis-derived weighting schemes (r=0·74).
  
  
  CONCLUSIONS
  The interruption of STH transmission is feasible, especially in countries with low intensity of transmission, supportive household environments, strong health systems, and the availability of suitable delivery platforms and in-country funds, but to achieve local elimination of STH an intersectoral approach to STH control will be needed.
  
  
  BACKGROUND
  Bill & Melinda Gates Foundation and Wellcome Trust.
authors.affiliation: Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: simon.brooker@lshtm.ac.uk.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Brooker
authors.affiliation: Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: Birgit
authors.initials: B
authors.lastname: Nikolay
authors.affiliation: Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: Dina
authors.initials: D
authors.lastname: Balabanova
authors.affiliation: Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Pullan
mesh_terms: D000818:Animals; D006373:Helminthiasis / Q000453:epidemiology* / Q000469:parasitology / Q000517:prevention & control*; D006376:Helminths; D006801:Humans; D015233:Models, Statistical; D058069:Neglected Diseases / Q000453:epidemiology / Q000469:parasitology; D012987:Soil / Q000469:parasitology*
chemical_list: D012987:Soil