title: Assessment of seizure risk in pre-clinical studies: Strengths and limitations of the electroencephalogram (EEG).
authors.affiliation: Smithers Viscient Laboratories, United States. Electronic address: mmetea@smithers.com.
authors.forename: Monica
authors.initials: M
authors.lastname: Metea
authors.affiliation: Department of Neuroscience, Albert Einstein College of Medicine, United States.
authors.forename: Mona
authors.initials: M
authors.lastname: Litwak
authors.affiliation: Department of Neuroscience, Albert Einstein College of Medicine, United States; Department of Neurology, Albert Einstein College of Medicine, United States.
authors.forename: Joseph
authors.initials: J
authors.lastname: Arezzo
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000175:diagnosis / Q000503:physiopathology; D004569:Electroencephalography / Q000379:methods*; D006801:Humans; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis; D013686:Telemetry / Q000379:methods
keywords: Convulsions; EEG spectral analysis; Electromyography/EMG; Preclinical seizure risk assessment; Premonitory signs; Regulatory drug development; Safety pharmacology; Seizure; Sharp waves; Telemetry; Tremors; Video-EEG