title: Synthesis and anticancer properties of fucoidan-mimetic glycopolymer coated gold nanoparticles.
abstract: Gold nanoparticles coated with fucoidan-mimetic glycopolymers were synthesized that displayed good colloidal stability and promising anti-cancer properties. Fucoidan mimetic glycopolymers on their own were nontoxic, while glycopolymer coated gold nanoparticles displayed selective cytotoxicity to human colon cancer cell lines (HCT116) while it was non-toxic to mouse fibroblast cells (NIH3T3).
authors.affiliation: Division of Organic Chemistry, Linköping University, SE-581 83, Linköping, Sweden.
authors.forename: Mattias
authors.initials: M
authors.lastname: Tengdelius
authors.forename: Deepanjali
authors.initials: D
authors.lastname: Gurav
authors.forename: Peter
authors.initials: P
authors.lastname: Konradsson
authors.forename: Peter
authors.initials: P
authors.lastname: Påhlsson
authors.forename: May
authors.initials: M
authors.lastname: Griffith
authors.forename: Oommen P
authors.initials: OP
authors.lastname: Oommen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D002809:Chondroitin Sulfates / Q000737:chemistry; D005347:Fibroblasts / Q000187:drug effects; D006046:Gold / Q000008:administration & dosage / Q000737:chemistry; D045325:HCT116 Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D051379:Mice; D041681:NIH 3T3 Cells; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D011108:Polymers; D011134:Polysaccharides; D006046:Gold; D002809:Chondroitin Sulfates; C007789:fucoidan