title: Ratio of spleen diameter to red blood cell distribution width: a novel indicator for celiac disease.
abstract: Celiac disease (CD) is currently considerably underdiagnosed, setting the need for developing tools to select patients with probability of CD, who warrant further testing. Red blood cell distribution width (RDW) has been shown in previous studies to be a sensitive predictor for CD, but it lacks specificity. Splenic hypotrophy is also noted frequently in celiac patients. Our aim was to evaluate if spleen diameter to RDW ratio can be used as an indicator for CD. We evaluated 15 newly diagnosed CD patients, 52 patients with inflammatory bowel disease, and 35 patients with irritable bowel syndrome (IBS). We evaluated the differences in spleen diameter, RDW, and their ratio among the four groups. Two-thirds of the CD patients had elevated RDW, compared to 9% in the IBS group. A small spleen was seen in 80% of the celiacs, compared to 21.9% in the ulcerative colitis group, 10% in the Crohn disease group, and 9% in the IBS group. A spleen diameter to RDW ratio under 6 had a sensitivity of 73.3% and specificity of 88.5% in predicting CD, with an AUROC of 0.737. Spleen diameter to RDW ratio is a simple, widely available score, which can be used to select adult patients with probability of CD.
authors.affiliation: From the "Dr Carol Davila" Central Military Emergency University Hospital (BDV, LAM, CRS, JM); "Carol Davila" University of Medicine and Pharmacy (BDV, PA, CRS, AIA, JM); "Alfred Rusescu" Institute for Mother and Child Care (PA, AIA), Bucharest, Romania; and Tampere Center for Child Health Research (PA), University of Tampere and Tampere University Hospital, Finland.
authors.forename: Daniel Vasile
authors.initials: DV
authors.lastname: Balaban
authors.forename: Alina
authors.initials: A
authors.lastname: Popp
authors.forename: Andrei Marian
authors.initials: AM
authors.lastname: Lungu
authors.forename: Raluca Simona
authors.initials: RS
authors.lastname: Costache
authors.forename: Ioana Alina
authors.initials: IA
authors.lastname: Anca
authors.forename: Mariana
authors.initials: M
authors.lastname: Jinga
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000175:diagnosis* / Q000503:physiopathology*; D003937:Diagnosis, Differential; D004912:Erythrocytes / Q000166:cytology*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology; D043183:Irritable Bowel Syndrome / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013154:Spleen / Q000033:anatomy & histology*