title: Progesterone support for frozen embryo transfer: intramuscular versus vaginal suppository demonstrates no difference in a cohort.
abstract: OBJECTIVE
  To evaluate pregnancy rates based on the route of progesterone replacement in frozen embryo transfer (FET) cycles.
  
  
  METHODS
  A randomized controlled trial and retrospective analysis. In the randomized group 76 FET cycles were randomized. In the retrospective group 508 FET cycles were reviewed. Intramuscular (IM) proges-erone in oil 100 mg daily or oral micronized progesterone prior to transfer followed by compounded vaginal proges-erone 200 mg 3 times daily (OV). The main outcome measure was the clinical pregnancy rate (CPR).
  
  
  RESULTS
  Baseline characteristics did not vary be-ween groups in either cohort. In the randomized group there were no significant differences in CPR (31.43% vs. 21.05%) or live birth rate (LBR) (31.43% vs. 18.92%) for IM and OV progesterone replacement, respectively. In the retrospective cohort patients there wore also no significant differences in CPR (35.56% vs. 32.35%) or LBR (32.23% vs. 28.51%)f or the IM and OVp rogester-ne replacement groups, respectively.
  
  
  CONCLUSIONS
  This study demonstrates that either OV or IM progesterone is effective for luteal phase support for FETs.
authors.forename: Phoebe H
authors.initials: PH
authors.lastname: Leonard
authors.forename: Alexis N
authors.initials: AN
authors.lastname: Hokenstad
authors.forename: Zaraq
authors.initials: Z
authors.lastname: Khan
authors.forename: Jani R
authors.initials: JR
authors.lastname: Jensen
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Stewart
authors.forename: Charles C
authors.initials: CC
authors.lastname: Coddington
mesh_terms: D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D015925:Cryopreservation; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D050498:Live Birth; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage*; D011372:Progestins / Q000008:administration & dosage*; D012189:Retrospective Studies; D013488:Suppositories
chemical_list: D011372:Progestins; D013488:Suppositories; D011374:Progesterone