title: Long-term outcome after pregnancy-related venous thrombosis.
abstract: There is limited knowledge of the long-term outcomes after pregnancy-related venous thrombosis (VT). Cohort studies monitoring long-term complications have never been conducted in this population, and the present evidence is based on data from a few observational studies. The risk of post-thrombotic syndrome (PTS) as a long-term complication after deep vein thrombosis (DVT) in pregnancy is considerable. It is most pronounced in women with a proximal DVT occurring postpartum. Quality of life (QOL) is reduced, but limited to women who develop PTS. Mortality is higher than in the general population during the first year after acute thrombosis, but not thereafter, and the long-term risk of cancer does not seem to be increased. The long-term risk of recurrent VT, subsequent arterial thrombosis, or chronic thromboembolic pulmonary hypertension is unknown and more research is highly warranted.
authors.affiliation: Department of Haematology, Oslo University Hospital, Oslo, Norway.
authors.forename: Hilde
authors.initials: H
authors.lastname: Skuterud Wik
authors.affiliation: Department of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
authors.forename: Anne
authors.initials: A
authors.lastname: Flem Jacobsen
authors.affiliation: Department of Haematology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: p.m.sandset@medisin.uio.no.
authors.forename: Per
authors.initials: P
authors.lastname: Morten Sandset
mesh_terms: D000293:Adolescent; D000328:Adult; D015897:Comorbidity; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000401:mortality*; D008137:Longitudinal Studies; D008875:Middle Aged; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000401:mortality* / Q000628:therapy*; D015995:Prevalence; D011379:Prognosis; D011788:Quality of Life; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000401:mortality* / Q000628:therapy*; D016387:Women's Health / Q000706:statistics & numerical data; D055815:Young Adult
keywords: Post-thrombotic syndrome; Pregnancy; Quality of life; Venous thrombosis