title: Heat shock factor 1 is a potent therapeutic target for enhancing the efficacy of treatments for multiple myeloma with adverse prognosis.
abstract: Deregulated expression of heat shock proteins (HSPs) encoding genes is frequent in multiple myeloma. HSPs, which are molecular chaperones involved in protein homeostasis pathways, have emerged recently as promising therapeutic targets. Using human myeloma cell lines and primary myeloma cells belonging to various molecular groups, we tested the efficacy of HSP90, HSP70, and heat shock factor 1 (HSF1) inhibitors alone or associated with current antimyeloma drugs. We report here that KNK-437 (an inhibitor of HSF1) and bortezomib have additive effects on apoptosis induction in cells belonging to groups with bad prognosis.
authors.affiliation: Normandie Univ, UNICAEN, EA4652, Caen, France. sophie.bustany@ch-flers.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Bustany
authors.affiliation: Normandie Univ, UNICAEN, EA4652, Caen, France. julie.cahu@gmail.com.
authors.forename: Julie
authors.initials: J
authors.lastname: Cahu
authors.affiliation: CRCNA, INSERM U892, CNRS UMR6299, Université de Nantes, Nantes, France. geraldine.descamps@univ-nantes.fr.
authors.forename: Géraldine
authors.initials: G
authors.lastname: Descamps
authors.affiliation: CRCNA, INSERM U892, CNRS UMR6299, Université de Nantes, Nantes, France. catherine.pellat-deceunynck@inserm.fr.
authors.forename: Catherine
authors.initials: C
authors.lastname: Pellat-Deceunynck
authors.affiliation: Normandie Univ, UNICAEN, EA4652, Caen, France. brigitte.sola@unicaen.fr.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Sola
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D001559:Benzhydryl Compounds / Q000008:administration & dosage; D015153:Blotting, Western; D000069286:Bortezomib / Q000008:administration & dosage; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D000076249:Heat Shock Transcription Factors; D006801:Humans; D009101:Multiple Myeloma / Q000378:metabolism / Q000473:pathology*; D011760:Pyrrolidinones / Q000008:administration & dosage; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
chemical_list: D001559:Benzhydryl Compounds; D004268:DNA-Binding Proteins; C000619706:HSF1 protein, human; D000076249:Heat Shock Transcription Factors; C410027:KNK 437; D011760:Pyrrolidinones; D014157:Transcription Factors; D000069286:Bortezomib