title: Pregabalin premedication - A new treatment option for hemodynamic stability during general anesthesia: A prospective study.
abstract: BACKGROUND
  Hemodynamic responses of laryngoscopy, intubation, and pain are powerful noxious stimulus which should be attenuated by the appropriate premedication, smooth induction, and rapid intubation.
  
  
  BACKGROUND
  The oral pregabalin may attenuate the hemodynamic pressor response with intraoperative hemodynamic stability.
  
  
  OBJECTIVE
  The present study was designed to evaluate the clinical efficacy and safety of oral pregabalin for hemodynamic stability.
  
  
  METHODS
  This is a prospective blind randomized controlled cohort observation study.
  
  
  METHODS
  The 80 adult consented patients of ASA grade I and II of either gender aged 24-54 years who met the inclusion criteria were randomized to receive oral pregabalin 150 mg or placebo capsule, given 60-75 min before surgery. Patients were premedicated with metoclopramide (10 mg), glycopyrrolate (0.2 mg), and fentanyl (1 μg/kg). Anesthesia was induced with propofol and rocuronium and maintained with isoflurane, nitrous oxide, and oxygen. Both groups were assessed for preoperative sedation and changes in heart rate and mean arterial blood pressure before and after the induction and 1, 3, 5, and 10 min after laryngoscopy and intubation, then at 5 min intervals till end of surgery along with postoperative complications.
  
  
  METHODS
  The hemodynamic variables were analyzed by using analysis of variance (ANOVA), Student's t test, and chi square test as appropriate.
  
  
  RESULTS
  Preoperative sedation was higher with pregabalin with no significant change in heart rate. The mean arterial pressure was attenuated with oral pregabalin to statistically significant value (P<0.007). The requirement of analgesic drug was reduced with no postoperative respiratory depression, nausea, or vomiting and hemodynamic parameters remained stabilized perioperatively.
  
  
  CONCLUSIONS
  Oral pregabalin premedication effectively leads to sedation and analgesia with successful attenuation of the adverse and deleterious hemodynamic pressor response.
authors.affiliation: Department of Anaesthesiology & Critical Care, N.S.C.B. Subharti Medical College, Subhartipuram, Meerut, Uttar Pradesh, India.
authors.forename: Kumkum
authors.initials: K
authors.lastname: Gupta
authors.affiliation: Department of Anaesthesiology & Critical Care, N.S.C.B. Subharti Medical College, Subhartipuram, Meerut, Uttar Pradesh, India.
authors.forename: Pranav
authors.initials: P
authors.lastname: Bansal
authors.affiliation: Department of Radio-Diagnosis, Imaging & Interventional Radiology, N.S.C.B. Subharti Medical College, Subhartipuram, Meerut, Uttar Pradesh, India.
authors.forename: Prashant K
authors.initials: PK
authors.lastname: Gupta
authors.affiliation: Department of Anaesthesiology & Critical Care, N.S.C.B. Subharti Medical College, Subhartipuram, Meerut, Uttar Pradesh, India.
authors.forename: Y P
authors.initials: YP
authors.lastname: Singh
keywords: Heart rate; hemodynamic response; laryngoscopy; mean arterial blood pressure; pregabalin; sedation