title: ALPPS and simultaneous right hemicolectomy - step one and resection of the primary colon cancer.
abstract: BACKGROUND
  Resection of the liver is often limited due to the volume of the parenchyma. To address this problem, several approaches to induce hypertrophy were developed. Recently, the 'associating liver partition and portal vein ligation for staged hepatectomy' (ALPPS) procedure was introduced and led to rapid hypertrophy in a short interval. Additionally to the portal vein occlusion, the parenchyma is transected, which disrupts the inter-parenchymal vascular connections. Since the first description of the ALPPS procedure, various reports around the world were published. In some cases, due to the high morbidity and mortality, a decent oncologic algorithm is not deliverable in a timely manner. If a patient is to be treated with a liver-first approach, the resection of the primary could sometimes be severely protracted. To overcome the problem, a simultaneous resection of the primary tumor and step one of ALPPS were performed.
  
  
  METHODS
  A 73-year-old male patient underwent portal vein embolization (PVE) after suffering from a synchronous hepatic metastasized carcinoma of the right colic flexure in order to perform a right trisectionectomy. Sufficient hypertrophy could not be obtained by PVE. Thus a 'Rescue-ALPPS' was undertaken. During step one of ALPPS, we simultaneously performed a right hemicolectomy. The postoperative course after the first step was uneventful, and sufficient hypertrophy was achieved.
  
  
  CONCLUSIONS
  In order to achieve a macroscopic disease-free state and lead the patient as soon as possible to the oncologic path (with, for example, chemotherapy), sometimes a simultaneous resection of the primary with step one of the ALPPS procedure seems justified. A resection of the primary with step two is not advisable, due to the high morbidity and mortality after this step. This case shows that a simultaneous resection is feasible and safe. Whether other locations of the primary should be treated this way must be part of further investigations.
authors.affiliation: Department of General and Abdominal Surgery, Asklepios Hospital Barmbek, Ruebenkamp 220, 22291, Hamburg, Germany. M.fard@asklepios.com.
authors.forename: Mohammad H
authors.initials: MH
authors.lastname: Fard-Aghaie
authors.affiliation: Department of General and Abdominal Surgery, Asklepios Hospital Barmbek, Ruebenkamp 220, 22291, Hamburg, Germany. g.stavrou@asklepios.com.|Semmelweis University, Asklepios Campus Hamburg, Lohmuehlenstrasse 5, 20099, Hamburg, Germany. g.stavrou@asklepios.com.
authors.forename: Gregor A
authors.initials: GA
authors.lastname: Stavrou
authors.affiliation: Department of General and Abdominal Surgery, Asklepios Hospital Barmbek, Ruebenkamp 220, 22291, Hamburg, Germany. k.schuetze@asklepios.com.
authors.forename: Kim C
authors.initials: KC
authors.lastname: Schuetze
authors.affiliation: Department of General and Abdominal Surgery, Asklepios Hospital Barmbek, Ruebenkamp 220, 22291, Hamburg, Germany. a.papalampros@asklepios.com.
authors.forename: Alexandros
authors.initials: A
authors.lastname: Papalampros
authors.affiliation: Department of General and Abdominal Surgery, Asklepios Hospital Barmbek, Ruebenkamp 220, 22291, Hamburg, Germany. m.donati@asklepios.com.
authors.forename: Marcello
authors.initials: M
authors.lastname: Donati
authors.affiliation: Department of General and Abdominal Surgery, Asklepios Hospital Barmbek, Ruebenkamp 220, 22291, Hamburg, Germany. k.oldhafer@asklepios.com.|Semmelweis University, Asklepios Campus Hamburg, Lohmuehlenstrasse 5, 20099, Hamburg, Germany. k.oldhafer@asklepios.com.
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Oldhafer
mesh_terms: D000368:Aged; D003082:Colectomy; D003110:Colonic Neoplasms / Q000473:pathology / Q000601:surgery*; D004621:Embolization, Therapeutic; D006498:Hepatectomy; D006801:Humans; D008026:Ligation; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008297:Male; D011169:Portal Vein / Q000473:pathology*