title: Systems medicine: evolution of systems biology from bench to bedside.
abstract: High-throughput experimental techniques for generating genomes, transcriptomes, proteomes, metabolomes, and interactomes have provided unprecedented opportunities to interrogate biological systems and human diseases on a global level. Systems biology integrates the mass of heterogeneous high-throughput data and predictive computational modeling to understand biological functions as system-level properties. Most human diseases are biological states caused by multiple components of perturbed pathways and regulatory networks rather than individual failing components. Systems biology not only facilitates basic biological research but also provides new avenues through which to understand human diseases, identify diagnostic biomarkers, and develop disease treatments. At the same time, systems biology seeks to assist in drug discovery, drug optimization, drug combinations, and drug repositioning by investigating the molecular mechanisms of action of drugs at a system's level. Indeed, systems biology is evolving to systems medicine as a new discipline that aims to offer new approaches for addressing the diagnosis and treatment of major human diseases uniquely, effectively, and with personalized precision.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Rui-Sheng
authors.initials: RS
authors.lastname: Wang
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.|Department of Cardiology, Veterans Affairs Boston Healthcare System, West Roxbury, MA, USA.
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Maron
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Loscalzo
mesh_terms: D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology; D004066:Digestive System Diseases / Q000378:metabolism / Q000473:pathology; D016678:Genome; D057166:High-Throughput Screening Assays; D006801:Humans; D008171:Lung Diseases / Q000378:metabolism / Q000473:pathology; D055442:Metabolome; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D057285:Precision Medicine; D020543:Proteome / Q000032:analysis; D049490:Systems Biology
chemical_list: D020543:Proteome