title: Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study.
abstract: BACKGROUND
  Factors associated with survival in pemphigus have not yet been thoroughly addressed. Therefore, in the present study, risk factors for overall mortality in a large group of patients with pemphigus vulgaris and foliaceus were investigated.
  
  
  METHODS
  A retrospective hospital-based cohort study was carried out, between October 1998 and November 2012, in the Department of Dermatology of the University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania. The investigated prognostic endpoint was the overall survival of the patients.
  
  
  RESULTS
  A total of 130 patients were studied (108 with pemphigus vulgaris and 22 with pemphigus foliaceus). In pemphigus vulgaris group, univariate analysis found a statistically significant association between the age of onset ≥ 65 years (p < 0.001), presence of coronary heart disease (p = 0.006), presence of cardiac arrhythmia (p = 0.004), level of anti-desmoglein1 autoantibodies ≥ 100 U/mL (p = 0.047) at diagnosis and the survival of the patients. An age-adjusted analysis showed significant results for coronary heart disease. Multivariate analysis identified the age of onset ≥ 65 years and the presence of coronary heart disease at diagnosis as independent risk factors associated with overall mortality. In patients with pemphigus foliaceus, age of onset ≥ 65 years (p = 0.021) was associated with poor survival.
  
  
  CONCLUSIONS
  In addition to common prognostic factors, including older age and cardiovascular comorbidities, level of autoantibodies was found to be a disease-specific factor associated with overall mortality in pemphigus vulgaris. The newly identified factors have major implications for the stratification of patients and should greatly facilitate further epidemiological studies in pemphigus. In addition, they provide useful information for the design of personalized therapeutic plans in the clinical setting.
authors.affiliation: Department of Dermatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. adrianbaican@yahoo.com.
authors.forename: Adrian
authors.initials: A
authors.lastname: Baican
authors.affiliation: Department of Dermatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. roxana.chiorean@uniklinik-freiburg.de.|Department of Dermatology, University Medical Center Freiburg, Hauptstrasse 7, 79104, Freiburg, Germany. roxana.chiorean@uniklinik-freiburg.de.
authors.forename: Roxana
authors.initials: R
authors.lastname: Chiorean
authors.affiliation: Department of Medical Informatics and Biostatistics, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. dleucuta@umfcluj.ro.
authors.forename: Daniel Corneliu
authors.initials: DC
authors.lastname: Leucuta
authors.affiliation: Department of Dermatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. cibaican@yahoo.com.
authors.forename: Corina
authors.initials: C
authors.lastname: Baican
authors.affiliation: Department of Dermatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. sorinadanescu@yahoo.com.
authors.forename: Sorina
authors.initials: S
authors.lastname: Danescu
authors.affiliation: Department of Dermatology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. dciuce@yahoo.co.uk.
authors.forename: Dorina
authors.initials: D
authors.lastname: Ciuce
authors.affiliation: Department of Dermatology, University Medical Center Freiburg, Hauptstrasse 7, 79104, Freiburg, Germany. cassian@mail.sitaru.eu.|Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg, Germany. cassian@mail.sitaru.eu.
authors.forename: Cassian
authors.initials: C
authors.lastname: Sitaru
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D012189:Retrospective Studies; D015996:Survival Rate