title: De novo malignancy after pancreas transplantation in Japan.
abstract: BACKGROUND
  Long-term immunosuppression is associated with an increased risk of cancer. Especially, the immunosuppression in pancreas transplantation is more intensive than that in other organ transplantation because of its strong immunogenicity. Therefore, it suggests that the risk of post-transplant de novo malignancy might increase in pancreas transplantation. However, there have been few studies of de novo malignancy after pancreas transplantation. The aim of this study was to analyze the incidence of de novo malignancy after pancreas transplantation in Japan.
  
  
  METHODS
  Post-transplant patients with de novo malignancy were surveyed and characterized in Japan.
  
  
  RESULTS
  Among 107 cases receiving pancreas transplantation in Japan between 2001 and 2010, de novo malignancy developed in 9 cases (8.4%): post-transplant lymphoproliferative disorders in 6 cases, colon cancer in 1 case, renal cancer in 1 case, and brain tumor in 1 case.
  
  
  CONCLUSIONS
  We clarified the incidence of de novo malignancy after pancreas transplantation in Japan.
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tomimaru
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan; Department of Complementary and Alternative Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan; The Japan Registry of Pancreas Transplantation, The Japan Society for Pancreas and Islet Transplantation, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan; The Japan Registry of Pancreas Transplantation, The Japan Society for Pancreas and Islet Transplantation, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Marubashi
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kawamoto
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tomokuni
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Asaoka
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Wada
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Eguchi
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Doki
authors.affiliation: Department of Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan. Electronic address: hnagano@gesurg.med.osaka-u.ac.jp.
authors.forename: H
authors.initials: H
authors.lastname: Nagano
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D007564:Japan; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D016035:Pancreas Transplantation; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology; D012306:Risk