title: Distinctive striatal dopamine signaling after dieting and gastric bypass.
abstract: Highly palatable and/or calorically dense foods, such as those rich in fat, engage the striatum to govern and set complex behaviors. Striatal dopamine signaling has been implicated in hedonic feeding and the development of obesity. Dieting and bariatric surgery have markedly different outcomes on weight loss, yet how these interventions affect central homeostatic and food reward processing remains poorly understood. Here, we propose that dieting and gastric bypass produce distinct changes in peripheral factors with known roles in regulating energy homeostasis, resulting in differential modulation of nigrostriatal and mesolimbic dopaminergic reward circuits. Enhancement of intestinal fat metabolism after gastric bypass may also modify striatal dopamine signaling contributing to its unique long-term effects on feeding behavior and body weight in obese individuals.
authors.affiliation: Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany.
authors.forename: Mohammed K
authors.initials: MK
authors.lastname: Hankir
authors.affiliation: Department of Surgery & Cancer, Imperial College London, London, UK. Electronic address: h.ashrafian@imperial.ac.uk.
authors.forename: Hutan
authors.initials: H
authors.lastname: Ashrafian
authors.affiliation: Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany; Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany.
authors.forename: Swen
authors.initials: S
authors.lastname: Hesse
authors.affiliation: Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany; Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Annette
authors.initials: A
authors.lastname: Horstmann
authors.affiliation: Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany.
authors.forename: Wiebke K
authors.initials: WK
authors.lastname: Fenske
mesh_terms: D000818:Animals; D001835:Body Weight; D003342:Corpus Striatum / Q000502:physiology*; D004038:Diet, Reducing; D004041:Dietary Fats; D004298:Dopamine / Q000502:physiology*; D004734:Energy Metabolism; D005247:Feeding Behavior / Q000502:physiology; D005518:Food Preferences; D015390:Gastric Bypass; D006706:Homeostasis; D006801:Humans; D009490:Neurosecretory Systems / Q000502:physiology; D009765:Obesity / Q000178:diet therapy / Q000601:surgery; D015398:Signal Transduction / Q000502:physiology*; D015430:Weight Gain
chemical_list: D004041:Dietary Fats; D004298:Dopamine
keywords: dieting; dopamine; gastric bypass; obesity; reward; striatum