title: Prosomeric organization of the hypothalamus in an elasmobranch, the catshark Scyliorhinus canicula.
abstract: The hypothalamus has been a central topic in neuroanatomy because of its important physiological functions, but its mature organization remains elusive. Deciphering its embryonic and adult organization is crucial in an evolutionary approach of the organization of the vertebrate forebrain. Here we studied the molecular organization of the hypothalamus and neighboring telencephalic domains in a cartilaginous fish, the catshark, Scyliorhinus canicula, focusing on ScFoxg1a, ScShh, ScNkx2.1, ScDlx2/5, ScOtp, and ScTbr1 expression profiles and on the identification α-acetylated-tubulin-immunoreactive (ir), TH-ir, 5-HT-ir, and GFAP-ir structures by means of immunohistochemistry. Analysis of the results within the updated prosomeric model framework support the existence of alar and basal histogenetic compartments in the hypothalamus similar to those described in the mouse, suggesting the ancestrality of these subdivisions in jawed vertebrates. These data provide new insights into hypothalamic organization in cartilaginous fishes and highlight the generality of key features of the prosomeric model in jawed vertebrates.
authors.affiliation: Centro de Investigaciones Biológicas, Department of Cell Biology and Ecology, University of Santiago de Compostela Santiago de Compostela, Spain.
authors.forename: Gabriel N
authors.initials: GN
authors.lastname: Santos-Durán
authors.affiliation: Centre National de la Recherche Scientifique, Experimental and Molecular Immunology and Neurogenetics, University of Orleans UMR7355, Orleans, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Menuet
authors.affiliation: Centre National de la Recherche Scientifique, FR2424, Development and Evolution of Vertebrates Group, Sorbonne Universités - Université Pierre et Marie Curie Roscoff, France.
authors.forename: Ronan
authors.initials: R
authors.lastname: Lagadec
authors.affiliation: Centre National de la Recherche Scientifique, FR2424, Development and Evolution of Vertebrates Group, Sorbonne Universités - Université Pierre et Marie Curie Roscoff, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Mayeur
authors.affiliation: Centre National de la Recherche Scientifique, FR2424, Development and Evolution of Vertebrates Group, Sorbonne Universités - Université Pierre et Marie Curie Roscoff, France.
authors.forename: Susana
authors.initials: S
authors.lastname: Ferreiro-Galve
authors.affiliation: Centre National de la Recherche Scientifique, FR2424, Development and Evolution of Vertebrates Group, Sorbonne Universités - Université Pierre et Marie Curie Roscoff, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Mazan
authors.affiliation: Centro de Investigaciones Biológicas, Department of Cell Biology and Ecology, University of Santiago de Compostela Santiago de Compostela, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Rodríguez-Moldes
authors.affiliation: Centro de Investigaciones Biológicas, Department of Cell Biology and Ecology, University of Santiago de Compostela Santiago de Compostela, Spain.
authors.forename: Eva
authors.initials: E
authors.lastname: Candal
keywords: Nkx2.1; Otp; Shh; chondrichthyan; development; evolution; forebrain patterning; prosomeric model