title: Promotion of wound healing by Plantago major L. leaf extracts--ex-vivo experiments confirm experiences from traditional medicine.
abstract: The wound-healing properties of Plantago major L. (plantain) were evaluated using an ex-vivo porcine wound-healing model. Ethanol- and water-based extracts were prepared from greenhouse-grown and freeze-dried leaves of P. major. Both types of extracts stimulated wound healing in porcine skin, but the ethanol-based extracts had a somewhat stronger effect. A concentration of 1.0 mg/mL (on dry weight basis) produced the best results for both types of extracts.
authors.affiliation: a Department of Plant Breeding - Balsgård , Swedish University of Agricultural Sciences , Fjälkestadsvägen 459, 291 94 Kristianstad , Sweden.|b Department of Bioinformatics and Biotechnology , Government College University (GCU) , Faisalabad , Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zubair
authors.affiliation: a Department of Plant Breeding - Balsgård , Swedish University of Agricultural Sciences , Fjälkestadsvägen 459, 291 94 Kristianstad , Sweden.
authors.forename: Hilde
authors.initials: H
authors.lastname: Nybom
authors.affiliation: c Sophiahemmet University College , Box 5605, 11486 Stockholm , Sweden.
authors.forename: Christina
authors.initials: C
authors.lastname: Lindholm
authors.affiliation: d Department of Dermatology and Venerology , University Hospital Hamburg-Eppendorf , Martinistrasse 52, 20246 Hamburg , Germany.
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Brandner
authors.affiliation: a Department of Plant Breeding - Balsgård , Swedish University of Agricultural Sciences , Fjälkestadsvägen 459, 291 94 Kristianstad , Sweden.
authors.forename: Kimmo
authors.initials: K
authors.lastname: Rumpunen
mesh_terms: D000818:Animals; D000431:Ethanol; D005612:Freeze Drying; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010943:Plantago / Q000737:chemistry*; D059808:Polyphenols / Q000737:chemistry / Q000494:pharmacology; D012867:Skin / Q000473:pathology; D012997:Solvents; D013552:Swine; D014867:Water; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D059808:Polyphenols; D012997:Solvents; D014867:Water; D000431:Ethanol
keywords: Plantaginaceae; Plantamajoside; Polyphenols; common plantain