title: Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing.
abstract: The first event in the initiation of eukaryotic DNA replication is the recruitment of the MCM2-7 ATPase, the core of the replicative DNA helicase, to origins. Ticau et al. use single-molecule imaging to reveal how ORC, Cdc6, and Cdt1 cooperate to load MCM2-7 onto DNA, enabling bidirectional replication.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Chistol
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Howard Hughes Medical Institute. Electronic address: johannes_walter@hms.harvard.edu.
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Walter
mesh_terms: D004261:DNA Replication; D064110:Minichromosome Maintenance Proteins / Q000378:metabolism*; D051738:Origin Recognition Complex / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism*
chemical_list: D051738:Origin Recognition Complex; D064110:Minichromosome Maintenance Proteins