title: Effect of different doses of transmitters on the mechanisms of adaptation.
abstract: We studied the responses of the organism to administration of autonomic transmitters in different doses: epinephrine (from 0.0000001 to 300 μg per 100 g body weight), serotonin (25, 50, 250, and 500 μg), and their combinations. The concentrations of biogenic amines in the blood and hypothalamus and parameters of oxidative and antioxidant systems, immune status, and blood coagulation and anticoagulation systems were analyzed. Cyclic dose-dependent variations in the levels of transmitters were revealed that dynamically changed their properties of syntoxins and catatoxins.
authors.affiliation: I. M. Sechenov First Moscow State Medical University, Moscow, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Zilov
authors.forename: A A
authors.initials: AA
authors.lastname: Khadartsev
authors.forename: V N
authors.initials: VN
authors.lastname: Morozov
authors.forename: K A
authors.initials: KA
authors.lastname: Khadartseva
mesh_terms: D000109:Acetylcholine / Q000097:blood; D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001679:Biogenic Amines / Q000097:blood*; D004334:Drug Administration Schedule; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D051381:Rats; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D001679:Biogenic Amines; D012701:Serotonin; D019344:Lactic Acid; D000109:Acetylcholine; D004837:Epinephrine