title: Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association.
abstract: The field of genetics and genomics has advanced considerably with the achievement of recent milestones encompassing the identification of many loci for cardiovascular disease and variable drug responses. Despite this achievement, a gap exists in the understanding and advancement to meaningful translation that directly affects disease prevention and clinical care. The purpose of this scientific statement is to address the gap between genetic discoveries and their practical application to cardiovascular clinical care. In brief, this scientific statement assesses the current timeline for effective translation of basic discoveries to clinical advances, highlighting past successes. Current discoveries in the area of genetics and genomics are covered next, followed by future expectations, tools, and competencies for achieving the goal of improving clinical care.
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Fox
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Hall
authors.forename: Donna K
authors.initials: DK
authors.lastname: Arnett
authors.forename: Euan A
authors.initials: EA
authors.lastname: Ashley
authors.forename: Christian
authors.initials: C
authors.lastname: Delles
authors.forename: Mary B
authors.initials: MB
authors.lastname: Engler
authors.forename: Mason W
authors.initials: MW
authors.lastname: Freeman
authors.forename: Julie A
authors.initials: JA
authors.lastname: Johnson
authors.forename: David E
authors.initials: DE
authors.lastname: Lanfear
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Liggett
authors.forename: Aldons J
authors.initials: AJ
authors.lastname: Lusis
authors.forename: Joseph
authors.initials: J
authors.lastname: Loscalzo
authors.forename: Calum A
authors.initials: CA
authors.lastname: MacRae
authors.forename: Kiran
authors.initials: K
authors.lastname: Musunuru
authors.forename: L Kristin
authors.initials: LK
authors.lastname: Newby
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: O'Donnell
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Rich
authors.forename: Andre
authors.initials: A
authors.lastname: Terzic
mesh_terms: D000572:American Heart Association; D000818:Animals; D001711:Biotransformation / Q000235:genetics; D002317:Cardiovascular Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000235:genetics*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005544:Forecasting; D014644:Genetic Variation; D023281:Genomics; D016045:Human Genome Project; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy; D057026:Induced Pluripotent Stem Cells; D051379:Mice; D058990:Molecular Targeted Therapy; D057170:Translational Research, Biomedical / Q000191:economics / Q000458:organization & administration / Q000639:trends*; D014481:United States
chemical_list: D002317:Cardiovascular Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: AHA Scientific Statements; DNA; HapMap Project; Human Genome Project; PCSK9 protein, mouse; adrenergic beta-antagonists; genetics; genome-wide association study; polymorphism, single nucleotide