title: Effect of Hashimoto thyroiditis on low-dose radioactive-iodine remnant ablation.
abstract: Radioactive-iodine remnant ablation is an integral part of the papillary thyroid carcinoma (PTC) treatment. Although a minimum dose is usually recommended, there is controversy as to whether the low-dose (1100 MBq) radioactive-iodine remnant ablation is adequate for selected patients.
  
  
  
  A retrospective cohort study was conducted on 691 patients. Patients with no remnant thyroid on the follow-up whole body scan and low stimulated thyroglobulin (sTg) level (<2.0 ng/mL) were deemed as successful treatment cases.
  
  
  
  Initial low-dose radioactive-iodine remnant ablation was successful in 431 patients (62.3%). Multivariate analysis demonstrated a negative correlation between successful radioactive-iodine remnant ablation and coexisting Hashimoto thyroiditis based on histopathology diagnosis (odds ratio [OR] = 3.23; p < .001) as well as elevated preablation sTg (OR = 1.24; p < .001).
  
  
  
  Our data suggest that coexisting Hashimoto thyroiditis and elevated sTg are negative predictive factors for successful low-dose radioactive-iodine remnant ablation treatment. An appropriate risk-adjusted approach may improve the efficacy of radioactive-iodine remnant ablation treatment. © 2015 Wiley Periodicals, Inc. Head Neck 38: E730-E735, 2016.
authors.affiliation: Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea.|Department of Surgery, Seoul National University Bundang Hospital and College of Medicine, Seongnam, Korea.
authors.forename: Hyungju
authors.initials: H
authors.lastname: Kwon
authors.affiliation: Department of Surgery, Seoul National University Bundang Hospital and College of Medicine, Seongnam, Korea.
authors.forename: June Young
authors.initials: JY
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Seoul National University Bundang Hospital and College of Medicine, Seongnam, Korea.
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Moon
authors.affiliation: Department of Pathology, Seoul National University Bundang Hospital and College of Medicine, Seongnam, Korea.
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Department of Nuclear Medicine, Seoul National University Bundang Hospital and College of Medicine, Seongnam, Korea.
authors.forename: Won Woo
authors.initials: WW
authors.lastname: Lee
authors.affiliation: Department of Surgery, Seoul National University Hospital and College of Medicine, Seoul, Korea.
authors.forename: Kyu Eun
authors.initials: KE
authors.lastname: Lee
mesh_terms: D000328:Adult; D005260:Female; D050031:Hashimoto Disease / Q000150:complications*; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000188:drug therapy*; D013965:Thyroidectomy; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes
keywords: Hashimoto thyroiditis; ablation; low dose; papillary thyroid carcinoma; radioiodine