title: [Treatment of adenomyosis (excluding pregnancy project)].
abstract: In this review we aimed to update the possibilities of adenomyosis treatment in women excluding those with a desire for pregnancy. Adenomyosis is defined as the presence of endometrial tissue within the myometrium and frequently underestimated. Over the last decades, its pathophysiology has been better known. The diagnosis is essentially based on clinical symptoms like menorrhagia and dysmenorrhea. Transvaginal ultrasound and magnetic resonance imaging are the main tools of the radiologic diagnosis. However, the definitive diagnosis is histological. The most effective treatment remains hysterectomy; however it is expensive, radical and at risk of morbidity compared with medical or surgical conservative management. The literature has reported several series of patients undergoing various treatments, thus allowing different therapeutic options. The levonorgestrel-releasing intrauterine device showed its efficacy alone or in combination with hysteroscopic treatment. Oral progestins, GnRH agonists are useful at short term or in preoperative condition. Some conservative treatments like focused ultrasound therapies or uterus-sparing operative treatment stay under evaluation and seems to be effective. Embolization has been the subject of several studies and must be outlined. Furthermore, several molecules, such as modulators of progesterone receptors and the aromatase inhibitors have been recently studied and are perhaps future treatments.
authors.affiliation: Service de gynécologie-obstétrique, hôpital Kremlin-Bicêtre, AP-HP, 78, avenue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France. Electronic address: lpelage@gmail.com.
authors.forename: L
authors.initials: L
authors.lastname: Pelage
authors.affiliation: Pôle obstétrique gynécologie reproduction, centre Aliénor-d'Aquitaine, hôpital Pellegrin, 33076 Bordeaux, France.
authors.forename: S
authors.initials: S
authors.lastname: Fenomanana
authors.affiliation: Pôle obstétrique gynécologie reproduction, centre Aliénor-d'Aquitaine, hôpital Pellegrin, 33076 Bordeaux, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Brun
authors.affiliation: Service de gynécologie-obstétrique, hôpital Kremlin-Bicêtre, AP-HP, 78, avenue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Levaillant
authors.affiliation: Service de gynécologie-obstétrique, hôpital Kremlin-Bicêtre, AP-HP, 78, avenue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France; CESP-Inserm U1018, « reproduction et développement de l'enfant », 82, rue du Général-Leclerc, 94276 Le Kremlin-Bicêtre cedex, France; Université Paris-Sud, 63, rue Gabriel-Péri, 94276 Le Kremlin-Bicêtre cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Fernandez
mesh_terms: D062788:Adenomyosis / Q000628:therapy*; D005260:Female; D006801:Humans
keywords: Adenomyomectomy; Adenomyosis; Adénomyomectomie; Adénomyose; Dispositif intra-utérin au lévonorgestrel; Embolisation; Embolization; Focalisées de haute intensité; High; Hysterectomy; Hysteroscopy; Hystérectomie; Hystéroscopie; Levonorgestrel-releasing intrauterine device; Ultrasons; Ultrasound focalized therapy