title: Tissue resident regulatory T cells: novel therapeutic targets for human disease.
abstract: Over the past decade, the ability of regulatory T cells (Tregs) to suppress multiple types of immune cells has received tremendous attention. Mounting evidence has revealed that tissue resident Tregs control non-immunological processes of their target tissues and contribute to a plethora of human diseases. The identification of novel tissue-specific Tregs has highlighted their heterogeneity and complexity. This review summarizes the recent findings for visceral adipose tissue CD4+Foxp3+ regulatory T cells (VAT Tregs), muscle Tregs, bone Tregs and skin memory Tregs, with a focus on their unique functions in local tissues. This interpretation of the roles of tissue-specific Tregs and of their involvement in disease progression provides new insight into the discovery of potential therapeutic targets of human diseases.
authors.affiliation: Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine.|Shanghai Heart Failure Research Center.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Heart Failure, Shanghai East Hospital, Tongji University School of Medicine.
authors.forename: Jiayou
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Heart Failure, Shanghai East Hospital, Tongji University School of Medicine.
authors.forename: Hao
authors.initials: H
authors.lastname: Cao
authors.affiliation: Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine.|Shanghai Heart Failure Research Center.|Department of Heart Failure, Shanghai East Hospital, Tongji University School of Medicine.
authors.forename: Huimin
authors.initials: H
authors.lastname: Fan
authors.affiliation: Key Laboratory of Molecular Virology & Immunology, Unit of Molecular Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Shanghai, 200120, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
mesh_terms: D004194:Disease; D006801:Humans; D007333:Insulin Resistance; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000276:immunology; D009765:Obesity / Q000276:immunology; D009928:Organ Specificity; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects* / Q000276:immunology*