title: Development of a photolabile protecting group for phosphodiesters in oligonucleotides.
abstract: A photolabile protecting group, consisting of an o-nitrobenzyl group and a 3-(2'-hydroxy-3',6'-dimethylphenyl)-2,2-dimethylpropyl moiety, was developed for phosphodiesters in oligodeoxyribonucleotides. Deprotection was triggered by photoirradiation and subsequent spontaneous cyclization to release the naked oligonucleotide.
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan. Electronic address: saneyoshih@kanagawa-u.ac.jp.
authors.forename: Hisao
authors.initials: H
authors.lastname: Saneyoshi
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
authors.forename: Kanami
authors.initials: K
authors.lastname: Shimamura
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Sagawa
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ando
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
authors.forename: Takahito
authors.initials: T
authors.lastname: Tomori
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Okamoto
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan. Electronic address: akiraono@kanagawa-u.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Ono
mesh_terms: D003500:Cyclization; D009841:Oligonucleotides / Q000737:chemistry*; D010777:Photochemistry
chemical_list: D009841:Oligonucleotides
keywords: Nucleic acid-based therapeutics; Prodrug; Protecting group