title: Going retro: ancient viral origins of cognition.
abstract: In this issue of Neuron, Zhang et al. (2015) provide the first crystal structure of a domain Arc. These results confirm prior computational approaches that suggested Arc, a master regulator of vertebrate synaptic plasticity, was "domesticated" from Ty3/Gypsy retrotransposons.
authors.affiliation: Gladstone Institutes of Neurological Disease, San Francisco, CA 94158, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Campioni
authors.affiliation: Gladstone Institutes of Neurological Disease, San Francisco, CA 94158, USA; Neuroscience Graduate Program, University of California, San Francisco, CA 94158, USA; Biomedical Science Graduate Program, University of California, San Francisco, CA 94143, USA; Taube-Koret Center for Neurodegenerative Disease, Gladstone Institutes, San Francisco, CA 94158, USA; Hellman Family Foundation Program in Alzheimer's Disease Research, Gladstone Institutes, San Francisco, CA 94158, USA; Department of Neurology, University of California, San Francisco, CA 94158, USA; Department of Physiology, University of California, San Francisco, CA 94158, USA. Electronic address: sfinkbeiner@gladstone.ucsf.edu.
authors.forename: Steven
authors.initials: S
authors.lastname: Finkbeiner
mesh_terms: D000818:Animals; D003072:Cognition Disorders / Q000378:metabolism*; D017781:Genes, Immediate-Early / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D018626:Retroelements / Q000502:physiology*; D013569:Synapses / Q000378:metabolism*
chemical_list: D018626:Retroelements