title: Association of insulin resistance with adipocytokine levels in patients with metabolic syndrome.
abstract: Metabolic syndrome (MetS) results from the derangement of adipocyte physiology and carbohydrate metabolism. Obesity and insulin resistance (IR) are integral features of MetS. The adipokine alterations in MetS often correlate with IR and body fat content. High adipose tissue content is associated with a decreased production of adiponectin and excessive production of tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6), all of which induce IR. The present study evaluated the adipokine alterations in MetS and their association with IR. The findings of the current study indicate that MetS is associated with significant decrease in adiponectin and increase in TNF-α and IL-6. The present study also found that the adipocyte derived inflammatory adipokines, TNF-α and IL-6 correlate with IR while the anti-inflammatory adipokines, adiponectin does not correlate with the degree and severity of IR.
authors.affiliation: Dianova Laboratories, Gandhinagar, Kottayam, Kerala 686 008 India.
authors.forename: Sajimon
authors.initials: S
authors.lastname: Thomas
authors.affiliation: Department of Biochemistry, School of Medical Education, Mahatma Gandhi University, Gandhinagar, Kottayam, Kerala 686 008 India.
authors.forename: S
authors.initials: S
authors.lastname: Suresh
authors.affiliation: Dianova Laboratories, Gandhinagar, Kottayam, Kerala 686 008 India.
authors.forename: M
authors.initials: M
authors.lastname: Sudheesh
authors.affiliation: Department of Basic Medical Sciences, Educare Institute of Dental Sciences, Malappuram, Kerala India.
authors.forename: T
authors.initials: T
authors.lastname: Vijayakumar
keywords: Adiponectin; Insulin resistance; Interleukin-6; Metabolic syndrome; Tumor necrosis factor alpha