title: The course and outcome of pregnancy in women with nondystrophic myotonias.
abstract: BACKGROUND
  Nondystrophic myotonias (NDM) are muscle channelopathies characterized by clinical and electrical myotonia. Little is known about pregnancy in NDM. The aim of this work was to assess pregnancy outcomes in women with NDM.
  
  
  METHODS
  In this investigation, we utilized a cross-sectional approach and obtained questionnaire data and medical record review information. Pregnancy outcomes were compared with U.S. national data.
  
  
  RESULTS
  Twenty-five women completed the study. There were 63 pregnancies with 53 live births, 8 miscarriages, 4 terminations, and 1 stillbirth. The infertility rate was 28% (above the U.S. average). Fetal distress was reported in 11.7% (U.S. average 3.6%) of the patients. NDM symptoms worsened in 62% of pregnancies. In those who worsened, symptoms usually resolved completely (66%) or partially (32%) after delivery in 2 days to 12 months, the majority (76%) within 3 months.
  
  
  CONCLUSIONS
  Most pregnancy outcomes were favorable. NDM worsened in nearly two-thirds of pregnancies, but usually improved shortly after delivery. Incidences of infertility and fetal distress were higher than overall U.S. rates.
authors.affiliation: Department of Neurology, University of Rochester Medical Center, 607 Elmwood Avenue, Rochester, P.O. Box 673, Rochester, New York, 14642, USA.
authors.forename: Yuliya
authors.initials: Y
authors.lastname: Snyder
authors.affiliation: Department of Neurology, University of Rochester Medical Center, 607 Elmwood Avenue, Rochester, P.O. Box 673, Rochester, New York, 14642, USA.
authors.forename: Colleen
authors.initials: C
authors.lastname: Donlin-Smith
authors.affiliation: Department of Neurology, University of Rochester Medical Center, 607 Elmwood Avenue, Rochester, P.O. Box 673, Rochester, New York, 14642, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Snyder
authors.affiliation: Department of Obstetrics and Gynecology, University of Rochester Medical Center, 607 Elmwood Avenue, Rochester, P.O. Box 673, Rochester, New York, 14642, USA.
authors.forename: Eva
authors.initials: E
authors.lastname: Pressman
authors.affiliation: Department of Neurology, University of Rochester Medical Center, 607 Elmwood Avenue, Rochester, P.O. Box 673, Rochester, New York, 14642, USA.
authors.forename: Emma
authors.initials: E
authors.lastname: Ciafaloni
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D009222:Myotonia / Q000503:physiopathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000209:etiology*; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: channelopathy; myotonia; myotonia congenital; nondystrophic myotonia; pregnancy