title: [The search of novel inhibitors of HIV-1 integrase among 5-(4-halogenophenyl)-5-oxopentyl derivatives of nucleic bases].
abstract: By alkylation of uracil, thymine, cytosine, adenine, 6-chloropurine, and 2-amino-6-chloropurine with 5-chloro-1-(4-halogenophenyl)-1-pentanones novel derivatives of nucleic bases were obtained, their physicochemical properties were studied. The influence of synthesized compounds on HIV-1 integrase was investigated.
authors.forename: V V
authors.initials: VV
authors.lastname: Komissarov
authors.forename: E S
authors.initials: ES
authors.lastname: Kniazhanskaia
authors.forename: A V
authors.initials: AV
authors.lastname: Atrokhova
authors.forename: M B
authors.initials: MB
authors.lastname: Gottikh
authors.forename: A M
authors.initials: AM
authors.lastname: Kritsyn
mesh_terms: D000225:Adenine / Q000737:chemistry; D000478:Alkylation; D003596:Cytosine / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006678:HIV / Q000187:drug effects / Q000201:enzymology; D015658:HIV Infections / Q000188:drug therapy* / Q000201:enzymology / Q000821:virology; D019427:HIV Integrase / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D011687:Purines / Q000737:chemistry; D013329:Structure-Activity Relationship; D013941:Thymine / Q000737:chemistry; D014498:Uracil / Q000737:chemistry
chemical_list: D004791:Enzyme Inhibitors; D011687:Purines; D014498:Uracil; D003596:Cytosine; D019427:HIV Integrase; D000225:Adenine; C079308:6-chloropurine; D013941:Thymine; C514801:p31 integrase protein, Human immunodeficiency virus 1