title: [Changes in serum level of carboxy-terminal telopeptide of type I collagen in patients with coronary heart disease].
abstract: OBJECTIVE
  To investigate the serum level of carboxy-terminal telopeptide of type I collagen (ICTP) and explore its correlation with MMP-2 and MMP-9 in patients with coronary artery disease (CHD).
  
  
  METHODS
  A total of 103 CHD patients treated in our hospital between October, 2013 and May, 2014 were enrolled, including 39 with stable angina pectoris (SAP), 39 with unstable angina (UA), and 25 with acute myocardial infarction (AMI), with 38 non-CHD volunteers as the control group. The serum levels of ICTP, MMP-2, and MMP-9 were detected in all the subjects using enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  No significant difference in serum levels of MMP-2, MMP-9, or ICTP was found between the control and SAP groups or between UA and AMI groups (P>0.05), but the latter two groups had significantly higher serum levels of MMP-2, MMP-9, and ICTP than the former two groups (P<0.05). Serum ICTP level was found to negatively correlated with the fibrotic area and positively with the lipid component in the plaques (P<0.05). Regression analysis revealed significant positive correlations of serum ICTP with MMP-2 and MMP-9 (P<0.05).
  
  
  CONCLUSIONS
  An elevated serum ICTP level is indicative of the presence of unstable plaques in CHD patients. Serum ICTP is more strongly correlated with MMP-2 than with MMP-9, and can be used as a non-invasive marker for assessing vulnerable plaques in patients with acute coronary syndrome.
authors.affiliation: Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangdong, Guangzhou 510280. E-mail: dengyierik@yahoo.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Deng
authors.forename: Li-Heng
authors.initials: LH
authors.lastname: Chen
authors.forename: Xian-Bao
authors.initials: XB
authors.lastname: Wang
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Song
authors.forename: Yuan-Na
authors.initials: YN
authors.lastname: Ling
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Chen
authors.forename: Ping-Zhen
authors.initials: PZ
authors.lastname: Yang
authors.forename: Jing-Bin
authors.initials: JB
authors.lastname: Guo
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Que
authors.forename: Gui-Ming
authors.initials: GM
authors.lastname: Chen
mesh_terms: D054058:Acute Coronary Syndrome; D000787:Angina Pectoris; D000789:Angina, Unstable; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D024042:Collagen Type I / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D009203:Myocardial Infarction
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9