title: Increased natural killer cell chemotaxis to CXCL12 in patients with multiple sclerosis.
abstract: Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease characterized by leukocyte infiltration into the central nervous system (CNS). Migration of lymphocyte subpopulations towards CXCL12 was analyzed coupled to six-color flow cytometry in untreated patients in the remitting phase, during relapse, in patients with clinically isolated syndrome (CIS), and in healthy volunteers. Significantly higher migration rates of natural killer cells (CD45+CD3-CD16/56+) were observed in patients in remission and CIS patients than in patients during relapse and in controls. Moreover, the frequency of CD3-CD16/56+CXCR4+ cells is higher in patients in remission and in CIS patients, but not during relapse.
authors.affiliation: Immunology Department, Hospital Universitario Central de Asturias, Oviedo 33011, Spain; Neurology Department, Hospital Universitario Central de Asturias, Oviedo 33011, Spain. Electronic address: e.serrano@ficyt.es.
authors.forename: Esther
authors.initials: E
authors.lastname: Serrano-Pertierra
authors.affiliation: Hospital Universitario Central de Asturias, OIB, Oviedo 33011, Spain. Electronic address: mabgelaz@gmail.com.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Blanco-Gelaz
authors.affiliation: Neurology Department, Hospital Universitario Central de Asturias, Oviedo 33011, Spain. Electronic address: pedro.oliva@sen.es.
authors.forename: Pedro
authors.initials: P
authors.lastname: Oliva-Nacarino
authors.affiliation: Oficina de Investigación Sanitaria, Asturias, Spain; Universidad Autónoma de Chile, Chile. Electronic address: pablomc@ficyt.es.
authors.forename: Pablo
authors.initials: P
authors.lastname: Martínez-Camblor
authors.affiliation: Neurology Department, Hospital Universitario Central de Asturias, Oviedo 33011, Spain. Electronic address: jvillafani@yahoo.com.
authors.forename: Javier
authors.initials: J
authors.lastname: Villafani
authors.affiliation: Immunology Department, Hospital Universitario Central de Asturias, Oviedo 33011, Spain; Fundación Renal Íñigo Álvarez de Toledo, Madrid 28003, Spain. Electronic address: inmuno@hca.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: López-Larrea
authors.affiliation: Neurology Department, Hospital Universitario Central de Asturias, Oviedo 33011, Spain. Electronic address: evacm@ficyt.es.
authors.forename: Eva
authors.initials: E
authors.lastname: Cernuda-Morollón
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002490:Central Nervous System / Q000473:pathology*; D054377:Chemokine CXCL12 / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects* / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D019718:Receptors, CXCR4 / Q000378:metabolism*; D055815:Young Adult
chemical_list: C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; D016207:Cytokines; D019718:Receptors, CXCR4
keywords: CXCL12; CXCR4; Chemotaxis; Multiple sclerosis; NK