title: Chlorhexidine-releasing orthodontic elastomerics.
abstract: The aim of this study was to identify the best combination of chlorhexidine (CHX) with orthodontic elastomerics for prevention of oral disease in orthodontic patients. We used ethyl cellulose (EC) as the polymer, and experimental groups were divided into five groups according to differences in solvent (i.e., ethanol; EtOH, dichloromethane; DCM). CHX release from the coated elastomerics was evaluated with a UV spectrophotometer and observed by scanning electron microscope (SEM). The antimicrobial release increased over time for 48 h in Group 3 (CDA+EC+30% EtOH/70% DCM), exhibiting the longest sustained-release characteristics (p<0.001). It also showed the highest antimicrobial properties, which was confirmed by inhibition zone testing using S. mutans (p<0.05). All groups were not affected when tensile force was tested in the coated elastomerics. We conclude that the antibacterial effect of CHX can be adjusted according to combinations of polymers and solvents. Group 3 exhibited the best substantivity and antimicrobial properties.
authors.affiliation: Department of Preventive Dentistry and Public Oral Health, Yonsei University College of Dentistry.
authors.forename: Hyun-Sun
authors.initials: HS
authors.lastname: Jeon
authors.forename: Choong-Ho
authors.initials: CH
authors.lastname: Choi
authors.forename: Si-Mook
authors.initials: SM
authors.lastname: Kang
authors.forename: Ho-Keun
authors.initials: HK
authors.lastname: Kwon
authors.forename: Baek-Il
authors.initials: BI
authors.lastname: Kim
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000494:pharmacology*; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D020724:Elastomers; D008422:Materials Testing; D009970:Orthodontics / Q000295:instrumentation*; D011108:Polymers / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013053:Spectrophotometry; D013295:Streptococcus mutans / Q000187:drug effects; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D000891:Anti-Infective Agents, Local; D003692:Delayed-Action Preparations; D020724:Elastomers; D011108:Polymers; D012997:Solvents; C036925:elastomeric polymer; D002710:Chlorhexidine