title: Long-term health-related quality of life in drug-resistant temporal lobe epilepsy after anterior temporal lobectomy.
abstract: Epilepsy surgery is beneficial to patients suffering from drug-resistant temporal lobe epilepsy in the short term, but fewer reports of long-term outcomes have been published. To clarify the long-term outcomes of seizure control and health-related quality of life after epilepsy surgery, we enrolled 48 patients suffering from drug-resistant temporal lobe epilepsy. All of the patients received comprehensive presurgical evaluations, including the Quality of Life in Epilepsy Inventory-89 (QOLIE-89) questionnaire to measure their health-related quality of life. Among the patients, 28 patients received surgery (surgical group) and 20 patients remained under medication (medical group). Eight years later, the seizure frequency and QOLIE-89 were evaluated. The seizure-free rate was much higher in the surgical group (53.6%) than in the medical group (5%), eight years after the initial evaluation. The follow-up QOLIE-89 score was significantly higher in the surgical group than in the medical group. Moreover, the seizure frequency inversely correlated to the QOLIE-89 score, regardless of the treatment group. Our results provide evidence that epilepsy surgery confers benefits with respect to seizure control and health-related quality of life for drug-resistant temporal lobe epilepsy patients based on long-term follow-up.
authors.affiliation: Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Department of Neurology, School of Medicine, National Yang-Ming University.
authors.forename: Chien-Chen
authors.initials: CC
authors.lastname: Chou
authors.affiliation: Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Department of Neurosurgery, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Yang-Hsin
authors.initials: YH
authors.lastname: Shih
authors.affiliation: Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Department of Neurology, School of Medicine, National Yang-Ming University.
authors.forename: Der-Jen
authors.initials: DJ
authors.lastname: Yen
authors.affiliation: Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Department of Neurology, School of Medicine, National Yang-Ming University.
authors.forename: Shang-Yeong
authors.initials: SY
authors.lastname: Kwan
authors.affiliation: Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Department of Neurology, School of Medicine, National Yang-Ming University.
authors.forename: Hsiang-Yu
authors.initials: HY
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D038481:Anterior Temporal Lobectomy / Q000379:methods*; D004351:Drug Resistance; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D011788:Quality of Life; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: anterior temporal lobectomy; drug-resistant epilepsy; epilepsy surgery; quality of life; seizure outcome; temporal lobe epilepsy