title: The sterilizing effect of pyriproxyfen on the malaria vector Anopheles gambiae: physiological impact on ovaries development.
abstract: Adult females An. gambiae were exposed in 3 min cone test to treated nets with PPF before or after they were blood fed. The effects of PPF on ovaries development, females oviposition and eggs hatching were assessed. Both unfed and fed mosquitoes exposed to PPF exhibited nearly complete inhibition of fecundity (70-100%) and fertility (90-100%). After females have been exposed once to PPF, the sterilizing effect on their fecundity was observed over 3 consecutive blood meals suggesting that PPF might have an irreversible sterilizing effect. Observation of the ovaries of exposed females to PPF under microscope revealed that the ovaries failed to develop even after several blood meals. The combination of PPF to pyrethroids on bednets could provide better malaria control tool and prevent the further development and spread of pyrethroid resistance in malaria vectors.
authors.affiliation: Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Ouagadougou, Burkina Faso. kwamajacques@yahoo.fr.
authors.forename: Bayili
authors.initials: B
authors.lastname: Koama
authors.affiliation: Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Ouagadougou, Burkina Faso. namountougou_d@yahoo.fr.|Universite Polytechnique de Bobo, Bobo-Dioulasso, Ouagadougou, Burkina Faso. namountougou_d@yahoo.fr.
authors.forename: Moussa
authors.initials: M
authors.lastname: Namountougou
authors.affiliation: Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Ouagadougou, Burkina Faso. sanourog@yahoo.fr.
authors.forename: Roger
authors.initials: R
authors.lastname: Sanou
authors.affiliation: Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Ouagadougou, Burkina Faso. severin.ndo@gmail.com.
authors.forename: Sévérin
authors.initials: S
authors.lastname: Ndo
authors.affiliation: Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Ouagadougou, Burkina Faso. ouattabcm@yahoo.fr.
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Ouattara
authors.affiliation: Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Ouagadougou, Burkina Faso. dabire_roch@hotmail.com.
authors.forename: Roch K
authors.initials: RK
authors.lastname: Dabiré
authors.affiliation: Innovative Vector Control Consortium, Liverpool, UK. David.Malone@liverpool.ac.uk.
authors.forename: David
authors.initials: D
authors.lastname: Malone
authors.affiliation: Institut de Recherche en Sciences de la Santé/Centre Muraz, Bobo-Dioulasso, Ouagadougou, Burkina Faso. a_diabate@hotmail.com.
authors.forename: Abdoulaye
authors.initials: A
authors.lastname: Diabaté
mesh_terms: D000818:Animals; D000852:Anopheles / Q000187:drug effects*; D005260:Female; D007303:Insect Vectors / Q000187:drug effects*; D057148:Insecticide-Treated Bednets; D007306:Insecticides / Q000494:pharmacology*; D008288:Malaria / Q000517:prevention & control / Q000635:transmission; D008297:Male; D009032:Mosquito Control / Q000379:methods*; D010053:Ovary / Q000187:drug effects*; D010058:Oviposition / Q000187:drug effects; D011725:Pyridines / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D011725:Pyridines; C055613:pyriproxyfen