title: Intraoral sebaceous carcinoma metastatic to the lung and subcutis: Case report and discussion of the literature.
abstract: BACKGROUND
  Intraoral sebaceous carcinoma is a rare form of sebaceous carcinoma with only 9 published cases in the world literature to date. We present a 10th case of intraoral sebaceous carcinoma located in the anterior maxillary gingiva with metastases to the lung and subcutis and discuss 3 possible etiologies for this unique presentation.
  
  
  METHODS
  We analyze the clinical presentation, pathology, histology, and genetic testing for a single case study and review relevant literature.
  
  
  RESULTS
  The histologic findings of the lung tumor and surgical excisions of the tumors in the gingiva and subcutis suggest the gingiva is the primary site. There is no evidence for the genetic abnormalities consistent with Muir-Torre syndrome.
  
  
  CONCLUSIONS
  The histologic findings suggest the oral cavity is the most likely site of tumor origin. This is the first case of intraoral sebaceous carcinoma reported to arise in the gingiva as well as to spread to cutaneous sites.
authors.affiliation: Department of Otolaryngology, Mount Sinai Beth Israel, New York, New York.|Thyroid, Head, and Neck Cancer (THANC) Foundation, New York, New York.
authors.forename: Meghan E
authors.initials: ME
authors.lastname: Rowe
authors.affiliation: Department of Radiology, Mount Sinai Beth Israel, New York, New York.
authors.forename: Azita S
authors.initials: AS
authors.lastname: Khorsandi
authors.affiliation: Thyroid, Head, and Neck Cancer (THANC) Foundation, New York, New York.
authors.forename: Grant R
authors.initials: GR
authors.lastname: Urken
authors.affiliation: Department of Pathology, Mount Sinai Beth Israel, New York, New York.|Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Wenig
mesh_terms: D018266:Adenocarcinoma, Sebaceous / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D000368:Aged; D001706:Biopsy; D002081:Buttocks / Q000473:pathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008297:Male; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D009361:Neoplasm Invasiveness; D012307:Risk Factors; D012626:Sebaceous Gland Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D012878:Skin Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery; D013848:Thigh / Q000473:pathology; D016896:Treatment Outcome
keywords: Fordyce granules; Muir-Torre syndrome; intraoral; oral metastases; sebaceous carcinoma