title: Response to Moras et al.
abstract: We recently reviewed full-length nuclear receptor (NR) structures in an Opinion article wherein we carefully evaluated a large body of literature. As heads of three separate laboratories working on NR architectures, we expressed our shared insights and critical comments. One group (Moras et al.) has declined to accept our strong concerns about several of their published reports. We comment on their letter.
authors.affiliation: Sanford-Burnham Medical Research Institute, Metabolic Disease Program, 6400 Sanger Road, Lake Nona, FL 32827, USA. Electronic address: frastinejad@sanfordburnham.org.
authors.forename: Fraydoon
authors.initials: F
authors.lastname: Rastinejad
authors.affiliation: Institut National de la Recherche Agronomique (INRA), Unité Mixte de Recherche 866 Dynamique Musculaire et Métabolisme, Université Montpellier 1, 34000 Montpellier, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Ollendorff
authors.affiliation: Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), Avenida Trabalhador São-Carlense 400, São Carlos, SP, 13560-970 Brazil.
authors.forename: Igor
authors.initials: I
authors.lastname: Polikarpov
mesh_terms: D004268:DNA-Binding Proteins / Q000737:chemistry*; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry*
chemical_list: D004268:DNA-Binding Proteins; D018160:Receptors, Cytoplasmic and Nuclear