title: Systemic impact molds mesenchymal stromal/stem cell aging.
abstract: Aging is associated with an accruing emergence of non-functional tissues. Mesenchymal stem cells (MSC) bring forth progenitors with multi-lineage differentiation potential, yet, they also exhibit anti-inflammatory and tissue-protective properties. Due to aging, altered tissue microenvironments constrict controlled stem cell proliferation and progenitor differentiation, thus diminishing the fitness of MSC. Therefore, deepening our understanding of metabolic, molecular and environmental factors impacting on MSC during human aging as well as providing new vistas on their role in promoting healthy aging and preventing age-associated disease is pivot. It is anticipated that integrative quantification of systemic parameters dominantly impacting on MSC will also enable effective personalized prognosis and provision of effective early medical interventions. Working along this line, it can be envisaged that standards in medical therapies can be individually adjusted by accounting not solely for the patient's chronological age or other physical parameters rather than specific physiological parameters which are believed to functionally shape stem cell niches within the bone marrow.
authors.affiliation: Institute for Biomedical Aging Research, University Innsbruck, Rennweg 10, Innsbruck A-6020, Austria.
authors.forename: Stephan
authors.initials: S
authors.lastname: Reitinger
authors.affiliation: Institute for Biomedical Aging Research, University Innsbruck, Rennweg 10, Innsbruck A-6020, Austria.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Schimke
authors.affiliation: Institute for Biomedical Aging Research, University Innsbruck, Rennweg 10, Innsbruck A-6020, Austria.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Klepsch
authors.affiliation: Institute for Biomedical Aging Research, University Innsbruck, Rennweg 10, Innsbruck A-6020, Austria.
authors.forename: Snezana
authors.initials: S
authors.lastname: de Sneeuw
authors.affiliation: Institute for Biomedical Aging Research, University Innsbruck, Rennweg 10, Innsbruck A-6020, Austria.
authors.forename: Stella Lukas
authors.initials: SL
authors.lastname: Yani
authors.affiliation: University Clinic for Maxillofacial Surgery Innsbruck, Anichstr. 35, Innsbruck A-6020, Austria.
authors.forename: Robert
authors.initials: R
authors.lastname: Gaßner
authors.affiliation: Austrian Institute for Technology, Muthgasse 11, Wien A-1190, Austria.
authors.forename: Peter
authors.initials: P
authors.lastname: Ertl
authors.affiliation: Institute for Biomedical Aging Research, University Innsbruck, Rennweg 10, Innsbruck A-6020, Austria; Department of Cell Biology and Genetics, University Salzburg, Hellbrunnerstr. 34, Salzburg 5020, Austria. Electronic address: guenter.lepperdinger@uibk.ac.at.
authors.forename: Günter
authors.initials: G
authors.lastname: Lepperdinger
mesh_terms: D000368:Aged; D001851:Bone Diseases, Metabolic / Q000235:genetics; D001853:Bone Marrow / Q000473:pathology; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D016922:Cellular Senescence; D006801:Humans; D007249:Inflammation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010010:Osteoclasts / Q000166:cytology; D012307:Risk Factors; D055153:Stem Cell Niche; D013234:Stem Cells / Q000166:cytology
keywords: Fitness; Mesenchymal stem cell; Niche; Osteopenia; Somatic maintenance