title: Regioselectivity of the C-metalation of 6-furylpurine: importance of directing effects.
abstract: We report the C-metalation of 6-furylpurine with Pt(2+), Pd(2+), and Hg(2+). The ligand binds the metal ions in a bidentate fashion, involving the N7 purine atom and one of the furyl carbon atoms. The regioselectivity is determined by the metal ion. Pt(2+) and Pd(2+) coordinate the furyl moiety in its β position and Hg(2+) in its electronically preferred α position.
authors.forename: Indranil
authors.initials: I
authors.lastname: Sinha
authors.forename: Alexander
authors.initials: A
authors.lastname: Hepp
authors.affiliation: §Organisch-Chemisches Institut and Center for Multiscale Theory and Computation, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: Birgitta
authors.initials: B
authors.lastname: Schirmer
authors.forename: Jutta
authors.initials: J
authors.lastname: Kösters
authors.affiliation: §Organisch-Chemisches Institut and Center for Multiscale Theory and Computation, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Neugebauer
authors.forename: Jens
authors.initials: J
authors.lastname: Müller