title: Pharmacogenomic test that predicts response to inhaled corticosteroids in adults with asthma likely to be cost-saving.
abstract: OBJECTIVE
  To identify the clinical and economic circumstances under which a pharmacogenomic test that predicts response to inhaled corticosteroids might be a cost-effective option for individuals with asthma.
  
  
  METHODS
  We synthesized published data on clinical and economic outcomes to project 10-year costs, quality-adjusted life-years and cost-effectiveness of pharmacogenomic testing for inhaled corticosteroid response. We assumed the pharmacogenomic test cost was $500 with a sensitivity and specificity of 84 and 98%, respectively. These were varied in sensitivity analyses.
  
  
  RESULTS
  Both strategies, pharmacogenomic testing for inhaled corticosteroid response and no testing conferred 7.1 quality-adjusted life-years. Compared with no testing, pharmacogenomic testing costs less.
  
  
  CONCLUSIONS
  Pharmacogenomic testing for asthma is cost-saving and noninferior in improving health. Original submitted 19 November 2014; Revision submitted 23 February 2015.
authors.affiliation: Center for Child Health Care Studies, Department of Population Medicine, Harvard Medical School & Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, Boston, MA 02215-5301, USA.
authors.forename: Ann Chen
authors.initials: AC
authors.lastname: Wu
authors.forename: Charlene
authors.initials: C
authors.lastname: Gay
authors.forename: Melisa D
authors.initials: MD
authors.lastname: Rett
authors.forename: Natasha
authors.initials: N
authors.lastname: Stout
authors.forename: Scott T
authors.initials: ST
authors.lastname: Weiss
authors.forename: Anne L
authors.initials: AL
authors.lastname: Fuhlbrigge
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage* / Q000191:economics*; D001249:Asthma / Q000188:drug therapy* / Q000191:economics*; D017046:Cost Savings / Q000191:economics* / Q000379:methods; D003362:Cost-Benefit Analysis / Q000191:economics / Q000379:methods; D005544:Forecasting; D006801:Humans; D010597:Pharmacogenetics / Q000191:economics* / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones
keywords: asthma; cost–effectiveness; inhaled corticosteroids; pharmacogenomics; predictive test