title: Genetic variants in AKR1B10 associate with human eating behavior.
abstract: BACKGROUND
  The human Aldoketoreductase 1B10 gene (AKR1B10) encodes one of the enzymes belonging to the family of aldoketoreductases and may be involved in detoxification of nutrients during digestion. Further, AKR1B10 mRNA (messenger ribonucleic acid) expression was diminished in brain regions potentially involved in the regulation of eating behavior in rats which are more sensitive to cocaine and alcohol. We hypothesized that the human AKR1B10 gene may also play a role in the regulation of human eating behavior.
  
  
  RESULTS
  We investigated the effects of 5 genetic variants of AKR1B10 on human eating behavior among 548 subjects from a German self-contained population, the Sorbs, and in 350 subjects from another independent German cohort. Among the Sorbs, we observed nominal associations with disinhibition at the 5' untranslated region (5' UTR) variant rs10232478 and the intragenic variants rs1834150 and rs782881 (all P ≤ 0.05). Further, we detected a relationship of rs1834150 and rs782881 with waist, smoking consumption (rs782881) and coffee consumption (rs1834150) (all P ≤ 0.05). Albeit non-significant, replication analyses revealed similar effect directions for disinhibition at rs1834150 (combined P = 0.0096). Moreover, in the replication cohort we found rs1834150 related to increased restraint scores with a similar direction as in the Sorbs (combined P = 0.0072).
  
  
  CONCLUSIONS
  Our data suggest that genetic variants in the AKR1B10 locus may influence human eating behavior.
authors.affiliation: IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany. Kerstin.Rohde@medizin.uni-leipzig.de.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Rohde
authors.affiliation: Max-Planck-Institute for Human Cognitive and Brain Sciences, Department of Neurology, Leipzig, Germany. federbusch@cbs.mpg.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Federbusch
authors.affiliation: IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany. horstmann@zimbra.cbs.mpg.de.|Max-Planck-Institute for Human Cognitive and Brain Sciences, Department of Neurology, Leipzig, Germany. horstmann@zimbra.cbs.mpg.de.
authors.forename: Annette
authors.initials: A
authors.lastname: Horstmann
authors.affiliation: IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany. Maria.Keller@medizin.uni-leipzig.de.
authors.forename: Maria
authors.initials: M
authors.lastname: Keller
authors.affiliation: IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany. Arno.Villringer@medizin.uni-leipzig.de.|Max-Planck-Institute for Human Cognitive and Brain Sciences, Department of Neurology, Leipzig, Germany. Arno.Villringer@medizin.uni-leipzig.de.|Clinic of Cognitive Neurology, University of Leipzig, Leipzig, Germany. Arno.Villringer@medizin.uni-leipzig.de.
authors.forename: Arno
authors.initials: A
authors.lastname: Villringer
authors.affiliation: IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany. Michael.Stumvoll@medizin.uni-leipzig.de.|Department of Medicine, University of Leipzig, Leipzig, Germany. Michael.Stumvoll@medizin.uni-leipzig.de.
authors.forename: Michael
authors.initials: M
authors.lastname: Stumvoll
authors.affiliation: Department of Medicine, University of Leipzig, Leipzig, Germany. Anke.Toenjes@medizin.uni-leipzig.de.
authors.forename: Anke
authors.initials: A
authors.lastname: Tönjes
authors.affiliation: IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany. Peter.Kovacs@medizin.uni-leipzig.de.
authors.forename: Peter
authors.initials: P
authors.lastname: Kovacs
authors.affiliation: IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany. Yvonne.Boettcher@medizin.uni-leipzig.de.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Böttcher
mesh_terms: D000328:Adult; D000449:Aldehyde Reductase / Q000235:genetics*; D000074408:Aldo-Keto Reductases; D000483:Alleles; D015331:Cohort Studies; D005247:Feeding Behavior; D056726:Genetic Association Studies; D014644:Genetic Variation; D005838:Genotype; D005858:Germany; D006801:Humans; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable
chemical_list: C120471:AKR1B10 protein, human; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase