title: Anisotropic encapsulation-induced synthesis of asymmetric single-hole mesoporous nanocages.
abstract: Asymmetric single-hole mesoporous silica nanocages, which are eccentric hollow structured spheres and consist of mesoporous shell with an open hole on their surface, with uniform particle size (100-240 nm), have successfully been synthesized via a novel anisotropic encapsulation of the mesoporous silica. In this unique nanocarrier, the eccentric hollow cavity and big hole (∼25 nm) can serve as a storage space and passage for large guest molecules. Meanwhile, the uniform mesopores (2-10 nm) with a high surface area (∼500 m(2)/g) in the silica shells of the nanocages can provide storage space for small guest molecules. The obtained single-hole mesoporous nanocages can be endowed upconversion luminescence. The obtained upconversion nanoparticles functionalized eccentric single-hole nanorattles were used to codeliver bovine serum albumin and doxorubicin dual-sized guests. The release of the dual-sized guests can be well controlled independently by heat and near-infrared (NIR) light with the assistance of NIR to ultraviolet/visible (UV/vis) optical properties of upconversion nanoparticles and heat-sensitive phase change materials.
authors.affiliation: †Laboratory of Advanced Materials, Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai 200433, P. R. China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Li
authors.affiliation: †Laboratory of Advanced Materials, Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai 200433, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhou
authors.affiliation: †Laboratory of Advanced Materials, Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai 200433, P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wei
authors.affiliation: ‡King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia.|§Central Metallurgical Research and Development Institute, CMRDI, Helwan 11421, Cairo, Egypt.
authors.forename: Ahmed Mohamed
authors.initials: AM
authors.lastname: El-Toni
authors.affiliation: †Laboratory of Advanced Materials, Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai 200433, P. R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: †Laboratory of Advanced Materials, Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai 200433, P. R. China.
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Zhao
mesh_terms: D016880:Anisotropy; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000138:chemical synthesis* / Q000737:chemistry; D013499:Surface Properties
chemical_list: D012822:Silicon Dioxide