title: Sensitivity of the Giant LOop Binary LEsion (GLOBLE) cell survival model on parameters characterising dose rate effects.
abstract: The sensitivity of the Giant LOop Binary LEsion model for cell survival probabilities after arbitrary photon irradiation schedules on its parameters is presented. Since these parameters are closely linked to observable features of cell repair, the modelled influence of the parameters on cell survival gives indications about the relation between cell line-specific repair characteristics and the radiation response. To visualise the general findings about the impact of parameter changes on cell survival probabilities, survival curves for an exemplary cell line are shown. Furthermore, the relative change in the effect of radiation after a change in parameter values is investigated over the range of doses and dose rates usually applied in cell survival experiments.
authors.affiliation: Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung (GSI), Darmstadt, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Herr
authors.affiliation: Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung (GSI), Darmstadt, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Friedrich
authors.affiliation: Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung (GSI), Darmstadt, Germany Technische Universität Darmstadt, Institut für Festkörperphysik, Darmstadt, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Durante
authors.affiliation: Department of Biophysics, GSI Helmholtzzentrum für Schwerionenforschung (GSI), Darmstadt, Germany m.scholz@gsi.de.
authors.forename: M
authors.initials: M
authors.lastname: Scholz
mesh_terms: D000465:Algorithms; D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D018499:Linear Energy Transfer; D008546:Melanoma, Experimental / Q000473:pathology* / Q000532:radiotherapy*; D051379:Mice; D008954:Models, Biological; D008962:Models, Theoretical; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D012062:Relative Biological Effectiveness; D014407:Tumor Cells, Cultured