title: Associations of ABHD2 genetic variations with risks for chronic obstructive pulmonary disease in a Chinese Han population.
abstract: The human α/β hydrolase domain-containing protein 2 gene (ABHD2) plays a critical role in pulmonary emphysema, a major subset of the clinical entity known as chronic obstructive pulmonary disease (COPD). Here, we evaluated genetic variation in the ABHD2 gene in a Chinese Han population of 286 COPD patients and 326 control subjects. The rs12442260 CT/CC genotype was associated with COPD (P < 0.001) under a dominant model. In the former-smoker group, the rs12442260 TT genotype was associated with a decreased risk of developing COPD after adjusting for age, gender and pack-years (P = 0.012). Rs12442260 was also associated with pre-FEV1 (the predicted bronchodilator forced expiratory volume in the first second) in controls (P = 0.027), but with FEV1/ forced vital capacity (FVC) ratios only in COPD patients (P = 0.012) under a dominant model. Results from the current study suggest that ABHD2 gene polymorphisms contribute to COPD susceptibility in the Chinese Han population.
authors.affiliation: Department of Histology and Embryology, Harbin Medical University, Harbin, Heilongjiang Province, 150018, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Division of Respiratory Disease, The Fourth Hospital of Harbin Medical University, Harbin, Harbin, Heilongjiang Province, 150001, China.
authors.forename: Xiangshun
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Histology and Embryology, Harbin Medical University, Harbin, Heilongjiang Province, 150018, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Yuan
authors.affiliation: Department of Histology and Embryology, Harbin Medical University, Harbin, Heilongjiang Province, 150018, China.
authors.forename: Honghong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Division of Respiratory Disease, The Fourth Hospital of Harbin Medical University, Harbin, Harbin, Heilongjiang Province, 150001, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Qiang
authors.affiliation: Department of Histology and Embryology, Harbin Medical University, Harbin, Heilongjiang Province, 150018, China.
authors.forename: Jingling
authors.initials: J
authors.lastname: Shen
authors.affiliation: Division of Respiratory Disease, The Fourth Hospital of Harbin Medical University, Harbin, Harbin, Heilongjiang Province, 150001, China.
authors.forename: Shoude
authors.initials: S
authors.lastname: Jin
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005541:Forced Expiratory Volume / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D006867:Hydrolases / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*
chemical_list: D006867:Hydrolases; C525115:ABHD2 protein, human