title: Occupational contact dermatitis caused by aniline epoxy resins in the aircraft industry.
abstract: BACKGROUND
  Tetraglycidyl-4,4'-methylenedianiline (TGMDA) is an aniline epoxy resin used in, for example, resin systems of pre-impregnated composite materials (prepregs) of the aircraft industry. Allergic contact dermatitis caused by TGMDA in prepregs has been described previously.
  
  
  OBJECTIVE
  To report on 9 patients with occupational allergic contact dermatitis caused by TGMDA in epoxy glues used in helicopter assembly.
  
  
  METHODS
  The patients were examined with patch testing at the Finnish Institute of Occupational Health in 2004-2009. The first patient was diagnosed by testing both components of two epoxy glues from the workplace, and was also tested with glue ingredients, including TGMDA. The following patients were tested with the glues and TGMDA. The resin parts of the glues were analysed for their epoxy compounds, including TGMDA.
  
  
  RESULTS
  All of the patients had a patch test reaction to one or both of the resin parts of the TGMDA-containing glues. Eight of them had a strong allergic reaction to TGMDA, and one had a doubtful reaction to TGMDA. Two of the patients also had an allergic reaction to triglycidyl-p-aminophenol (TGPAP), another aniline epoxy resin, which was not present in the TGMDA-containing glues.
  
  
  CONCLUSIONS
  In aircraft industry workers with suspected occupational dermatitis, aniline epoxy resins should be considered and patch tested as possible contact allergens.
authors.affiliation: Occupational Medicine, Finnish Institute of Occupational Health (FIOH), 00250, Helsinki, Finland.
authors.forename: Maria
authors.initials: M
authors.lastname: Pesonen
authors.affiliation: Occupational Medicine, Finnish Institute of Occupational Health (FIOH), 00250, Helsinki, Finland.
authors.forename: Katri
authors.initials: K
authors.lastname: Suuronen
authors.affiliation: Occupational Medicine, Finnish Institute of Occupational Health (FIOH), 00250, Helsinki, Finland.
authors.forename: Riitta
authors.initials: R
authors.lastname: Jolanki
authors.affiliation: Occupational Medicine, Finnish Institute of Occupational Health (FIOH), 00250, Helsinki, Finland.
authors.forename: Kristiina
authors.initials: K
authors.lastname: Aalto-Korte
authors.affiliation: Occupational Medicine, Finnish Institute of Occupational Health (FIOH), 00250, Helsinki, Finland.
authors.forename: Outi
authors.initials: O
authors.lastname: Kuuliala
authors.affiliation: Work Environment Development, FIOH, 20520, Turku, Finland.
authors.forename: Maj-Len
authors.initials: ML
authors.lastname: Henriks-Eckerman
authors.affiliation: Tampere Occupational Health Organization, 35800, Mänttä, Finland.
authors.forename: Ilona
authors.initials: I
authors.lastname: Valtanen
authors.affiliation: Occupational Medicine, Finnish Institute of Occupational Health (FIOH), 00250, Helsinki, Finland.
authors.forename: Kristiina
authors.initials: K
authors.lastname: Alanko
mesh_terms: D000401:Aircraft; D000627:Aminophenols / Q000009:adverse effects; D000814:Aniline Compounds / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology*; D004852:Epoxy Compounds / Q000009:adverse effects*; D004853:Epoxy Resins / Q000009:adverse effects; D005148:Facial Dermatoses / Q000209:etiology*; D005387:Finland; D006801:Humans; D008297:Male; D066192:Manufacturing Industry; D010328:Patch Tests
chemical_list: D000627:Aminophenols; D000814:Aniline Compounds; D004852:Epoxy Compounds; D004853:Epoxy Resins; C414224:triglycidyl-p-aminophenol; C042844:diglycidylaniline; C042840:tetraglycidyl-4,4'-methylene dianiline
keywords: N,N′-diglycidyl-4-glycidyloxyaniline; allergic contact dermatitis; glues; helicopter assembly; tetraglycidyl-4,4′-methylenedianiline