title: Angiomyomatous hamartoma in an inguinal lymph node with proliferating pericytes/smooth muscle cells, plexiform vessel tangles, and ectopic calcification.
abstract: Angiomyomatous hamartoma (AMH) is a rare benign lesion, which occurs almost exclusively in the inguinal lymph nodes. We herein report a case of a female elder who presented with a long-standing inguinal mass. Microscopically, the mass showed a zonal distribution, characterized by thick-walled muscular vessels, fibrosis, and calcification in the hilum and proliferating spindle cells around thin-walled vessels and plexiform vessel tangles at the periphery. The spindle cells show positive immunoreactivity of smooth muscle actin and CD34 with a heterogeneous expression of desmin and CD44. Although the pathogenesis of AMH remains uncertain, the histological features and immunohistochemical findings of this case imply a disordered or exuberant angiogenic process.
authors.affiliation: Department of Pathology, Taipei Medical University, Taipei, Taiwan.
authors.forename: Chii-Hong
authors.initials: CH
authors.lastname: Lee
authors.forename: Tung-Cheng
authors.initials: TC
authors.lastname: Chang
authors.forename: Jan-Wen
authors.initials: JW
authors.lastname: Ku
mesh_terms: D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002114:Calcinosis; D003893:Desmin / Q000032:analysis; D005260:Female; D005355:Fibrosis; D006222:Hamartoma / Q000175:diagnosis* / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D008853:Microscopy; D032342:Muscle Cells / Q000473:pathology; D020286:Pericytes / Q000473:pathology
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; C497483:CD44 protein, human; D003893:Desmin; D018960:Hyaluronan Receptors