title: Presentation and outcome of a cluster of patients with endogenous endophthalmitis: a case series.
abstract: BACKGROUND
  The aim of this study was to investigate the clinical features and visual acuity outcomes associated with endogenous endophthalmitis.
  
  
  METHODS
  Seven eyes of 6 patients treated at Epsom and St Helier University Hospitals between 2010 and 2013 were reviewed for endogenous endophthalmitis.
  
  
  RESULTS
  Patients were followed for a mean of 7 months (range 1 to 13). Positive blood cultures were obtained in 5 patients (83%), including 1 patient with fungal isolates (17%), two patients with Gram-positive isolates and another two with Gram-negative isolates. Five patients (83%) were hospitalized at the time of diagnosis and 2 patients (33%) died within 6 months of diagnosis. Initial treatment included vitreous tap and injection of intravitreal antibiotics. Only in one eye (14%) were positive results from the biopsy obtained. Four eyes (57%) achieved a final visual acuity of >6/60. Patients with a Klebsiella endophthalmitis had worse visual outcome.
  
  
  CONCLUSIONS
  Endogenous endophthalmitis is generally associated with high mortality and poor visual acuity outcomes. Gram-negative species are associated with poorer visual acuity. Vitreous biopsy has a weak diagnostic relevance as is it often negative.
authors.affiliation: Sutton Eye Unit, Epsom and St. Helier University Hospitals, NHS Trust (Lead Clinician: Miss Jane Leitch), London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Guber
authors.affiliation: Sutton Eye Unit, Epsom and St. Helier University Hospitals, NHS Trust (Lead Clinician: Miss Jane Leitch), London, UK.
authors.forename: M U
authors.initials: MU
authors.lastname: Saeed
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000627:therapeutic use; D009877:Endophthalmitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D015817:Eye Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D014792:Visual Acuity
chemical_list: D000890:Anti-Infective Agents