title: Association of the rs1801133 variant in the MTHFR gene and sporadic Parkinson's disease.
abstract: The MTHFR gene has been reported as a susceptibility locus for sporadic Parkinson's disease (sPD). The functional variant rs1801133 has been linked to hyperhomocysteinemia and dopaminergic cell death. Among different populations, Mexican-Mestizos (most present-day Mexicans) have the highest frequency of this variant. Therefore, we sought to determine a possible association of rs1801133 with SPD. In total, 356 individuals were included: 140 patients with PD, diagnosed according to the Queen Square Brain Bank criteria, and 216 neurologically healthy controls. Genotyping was performed using TaqMan probes for rs1801133 and real-time PCR. Logistic regression analysis with adjustment for smoking and gender was used to test for an association between genotype and SPD. The CC genotype was associated with SPD; exp() = 2.06; 95% CI: 1.101-3.873, p = 0.024. No association with age at onset, cognitive impairment or gender was found in our study group. Our data suggest an important role of MTHFR gene variants in SPD.
authors.forename: S
authors.initials: S
authors.lastname: García
authors.forename: Rm
authors.initials: R
authors.lastname: Coral-Vázquez
authors.forename: M P
authors.initials: MP
authors.lastname: Gallegos-Arreola
authors.forename: L A
authors.initials: LA
authors.lastname: Montes-Almanza
authors.forename: P
authors.initials: P
authors.lastname: Canto
authors.forename: F A
authors.initials: FA
authors.lastname: García-Martínez
authors.forename: G
authors.initials: G
authors.lastname: Chavira-Hernández
authors.forename: C
authors.initials: C
authors.lastname: Palma-Flores
authors.forename: L
authors.initials: L
authors.lastname: Dávila-Maldonado
authors.forename: C F
authors.initials: CF
authors.lastname: Cuevas-García
authors.affiliation: Luz Berenice López Hernández, PhD, Subdirección de Enseñanza e Investigación, Centro Médico Nacional 20 de Noviembre, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, San Lorenzo 502, C.P. 03100, México, D.F., México, phone: 01 52 55 52 00 50 03, fax: 01 52 33 36 32 62 00, e-mail: lblhmedgen@gmail.com.
authors.forename: L B
authors.initials: LB
authors.lastname: López Hernández
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)