title: Simple access to β-trifluoromethyl-substituted ketones via copper-catalyzed ring-opening trifluoromethylation of substituted cyclopropanols.
abstract: Tertiary cyclopropanols react rapidly with Togni reagent in methanol at room temperature in the presence of catalytic amounts (3 mol%) of CuCl affording β-trifluoromethyl ketones in 65-73% isolated yields. Ring opening in 1,2-dialkylsubstituted cyclopropanols gives a mixture of isomeric β-trifluoromethyl ketones in about 50% combined yield.
authors.affiliation: Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia. dzmitry.kananovich@ttu.ee margus.lopp@ttu.ee.
authors.forename: Dzmitry G
authors.initials: DG
authors.lastname: Kananovich
authors.forename: Yulia A
authors.initials: YA
authors.lastname: Konik
authors.forename: Dzmitry M
authors.initials: DM
authors.lastname: Zubrytski
authors.forename: Ivar
authors.initials: I
authors.lastname: Järving
authors.forename: Margus
authors.initials: M
authors.lastname: Lopp
mesh_terms: D000478:Alkylation; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*
chemical_list: D004988:Ethers, Cyclic; D007659:Ketones; C043657:cyclopropanol; D003300:Copper