title: Evaluation of immunity status to routine vaccination in pediatric liver transplant candidates.
abstract: OBJECTIVE
  Generally, prevention of infections by vaccination is the least invasive and most cost-effective approach to reduce the incidence of infections and the morbidity and mortality in transplant recipients. Genetic diversity and different liver disease among patients contributes to variability in immune responses to vaccines and pathogens. The aim of this study was to evaluate immunity status to different vaccinated organisms in pediatric liver-transplant candidates.
  
  
  METHODS
  The vaccination charts of 90 patients who were referred to Organ Transplant Center of Shiraz University of Medical Sciences were reviewed and compare with National Immunization Program recommendation, after that 10 mL blood was drawn from these patients for serologic studies by ELISA.
  
  
  RESULTS
  Eighty percent of the patients had protective antibody titers for poliomyelitis, 65.6% for rubella, 62.3% for diphtheria, 60% for tetanus, 57.7% for pertussis, 55.5% for measles, 42.2% for hepatitis B and 36.7% for mumps.
  
  
  CONCLUSIONS
  Overall seroconversion rates were not satisfactory for many infections that may be due to lower rate of vaccination or even the underlying liver disease that interfere with optimal immunogenecity of vaccination. Therefore, vaccination charts should be periodically reviewed and updated, also repeated measurements of serum antibodies and appropriate revaccination if titers decline is recommended to prevent the vaccine-preventable disease in liver transplant candidates after transplant.
authors.affiliation: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran; Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran. dehghanism@sums.ac.ir.
authors.forename: Seyed Mohsen
authors.initials: SM
authors.lastname: Dehghani
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Shakiba
authors.forename: Maziyar
authors.initials: M
authors.lastname: Ziaeyan
authors.forename: Mohammad Hadi
authors.initials: MH
authors.lastname: Imanieh
authors.forename: Mahmood
authors.initials: M
authors.lastname: Haghighat
authors.forename: Majid
authors.initials: M
authors.lastname: Sedaghat
authors.forename: Abdolvahab
authors.initials: A
authors.lastname: Alborzi
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Malek-Hosseini
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D001886:Bordetella pertussis / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003017:Clostridium tetani / Q000276:immunology; D003353:Corynebacterium diphtheriae / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007115:Immunization Schedule; D007121:Immunocompetence; D007223:Infant; D008107:Liver Diseases / Q000276:immunology*; D016031:Liver Transplantation; D008297:Male; D008459:Measles virus / Q000276:immunology; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology; D017955:Poliovirus / Q000276:immunology; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage / Q000276:immunology*; D011300:Preoperative Care; D012412:Rubella virus / Q000276:immunology; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D017325:Hepatitis B Vaccines; D022542:Measles-Mumps-Rubella Vaccine; D011055:Poliovirus Vaccine, Oral