title: Fate determination in mesenchymal stem cells: a perspective from histone-modifying enzymes.
abstract: Mesenchymal stem cells (MSCs) hold great promise for therapeutic use in regenerative medicine and tissue engineering. A detailed understanding of the molecular processes governing MSC fate determination will be instrumental in the application of MSCs. Much progress has been made in recent years in defining the epigenetic events that control the differentiation of MSCs into different lineages. A complex network of transcription factors and histone modifiers, in concert with specific transcriptional co-activators and co-repressors, activates or represses MSC differentiation. In this review, we summarize recent progress in determining the effects of histone-modifying enzymes on the multilineage differentiation of MSCs. In addition, we propose that the manipulation of histone signatures associated with lineage-specific differentiation by small molecules has immense potential for the advancement of MSC-based regenerative medicine.
authors.affiliation: Key Laboratory for Regenerative Medicine, Ministry of Education, Epithelial Cell Biology Research Centre, School of Biomedical Sciences, Lo Kwee-Seong Integrated Biomedical Sciences Building, Shatin, New Territories, Hong Kong, PR China. biaohb5568376@gmail.com.
authors.forename: Biao
authors.initials: B
authors.lastname: Huang
authors.affiliation: Department of Orthopaedics & Traumatology, Li Ka Shing Institute of Health Science, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, New Territories, Hong Kong, PR China. gangli@cuhk.edu.hk.|Lui Che Woo Institute of Innovative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China. gangli@cuhk.edu.hk.|School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, 518057, China. gangli@cuhk.edu.hk.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: Key Laboratory for Regenerative Medicine, Ministry of Education, Epithelial Cell Biology Research Centre, School of Biomedical Sciences, Lo Kwee-Seong Integrated Biomedical Sciences Building, Shatin, New Territories, Hong Kong, PR China. xjiang@cuhk.edu.hk.|Lui Che Woo Institute of Innovative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, SAR, China. xjiang@cuhk.edu.hk.|School of Biomedical Sciences Core Laboratory, The Chinese University of Hong Kong Shenzhen Research Institute, Shenzhen, 518057, China. xjiang@cuhk.edu.hk.
authors.forename: Xiao Hua
authors.initials: XH
authors.lastname: Jiang
mesh_terms: D002454:Cell Differentiation; D019070:Cell Lineage; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D048091:Guided Tissue Regeneration / Q000379:methods; D042421:Histone Code / Q000502:physiology*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D044968:Regenerative Medicine; D023822:Tissue Engineering / Q000379:methods*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D006657:Histones; D036341:Intercellular Signaling Peptides and Proteins; D014157:Transcription Factors