title: [Leukocyte chemotactic factor 2 associated renal amyloidosis: one case report].
abstract: Here we report a case of leukocyte chemotactic factor 2 (LECT2)-associated renal amyloidosis (ALect2) in our hospital. A 68-year-old male presented with massive proteinuria, hematuria, and hypertension. The renal function was normal. Light microscopy of the renal biopsy revealed glomeruli ,interstitium and arteriole with amorphous pink acellular deposits on hematoxylin and eosin stain. The deposits were strongly stained for Congo red and presented apple green birefringence viewed with polarized light. Ultrastructural examination revealed nonbranching fibrils (diameters ranging from 8 nm to 12 nm) distributed in glomerular mesangium, subendothelia and renal interstitium. Immunohistochemistry and immunoelectron microscopy using a polyclonal anti-LECT2 antibody showed that the amyloid deposits and the fibrils were stained positively. ALect2 presented proteinuria,with or without acute/chronic renal dysfunction clinically and all compartments of the kidney were involved.
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing 100034, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing 100034, China.
authors.forename: S X
authors.initials: SX
authors.lastname: Wang
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education of China, Beijing 100034, China.
authors.forename: Y K
authors.initials: YK
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000686:Amyloidosis; D001706:Biopsy; D005920:Glomerular Mesangium; D006417:Hematuria; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases; D007678:Kidney Glomerulus; D007962:Leukocytes; D008297:Male; D009392:Nephrectomy; D011507:Proteinuria; D013194:Staining and Labeling
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; C103468:LECT2 protein, human