title: [Study of the effect of colloidal solution of silver nanoparticles on parameters of cardio- and hemo-dynamics in rabbits].
abstract: Metal nanoparticles and silver nanoparticles in particular are extensively studied recently considering their prominent antimicrobial properties. Nevertheless, their toxicity aspects and probable side effects remain not well studied. In this article the results of study of the influence of silver nanoparticles onto a cardiovascular system in an in vivo experiment were provided, changes in parameters of cardio- and hemodynamics were defined, and the principles of such influence were identified. Dose-dependent effect of these nanoparticles was established when administered in dose of 4.3 mg/kg three times and 20 mg/kg once.
authors.forename: A O
authors.initials: AO
authors.lastname: Pryskoka
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003102:Colloids; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects*; D007275:Injections, Intravenous; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D010316:Particle Size; D011673:Pulsatile Flow / Q000187:drug effects; D011817:Rabbits; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects
chemical_list: D003102:Colloids; D012834:Silver