title: Nonalcoholic fatty liver disease induced by 13-week oral administration of 1,3-dichloro-2-propanol in C57BL/6J mice.
abstract: 1,3-Dichloro-2-propanol (1,3-DCP) is a food born chloropropanol contaminant that has been detected during the production process of a wide range of foods. In this study, we investigated the effect of 1,3-DCP on lipid metabolism of mice after 13-week subchronic exposure. The data showed that 1,3-DCP (0.05-0.5mg/kg/day) could induce nonalcoholic fatty liver disease (NAFLD) in C57BL/6J mice and the NOAEL was 0.01mg/kg/day. In addition, we studied the signaling pathway to see how 1,3-DCP worked. The data showed that NAFLD induced by 1,3-DCP was due to the dysregulation of AMPK signaling pathway. As far as we are aware, this is the first study to use 13-week subchronic toxicology to investigate the effect of 1,3-DCP on the development of NAFLD in mice. Our study provided evidence for diet contaminants in the development of NAFLD and furthered the safety evaluation of 1,3-DCP through subchronic exposure.
authors.affiliation: Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China; Key Laboratory of Zoonosis Research Ministry of Education, Jilin University, Changchun, Jilin 130062, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.affiliation: Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
authors.forename: Baochen
authors.initials: B
authors.lastname: Fang
authors.affiliation: Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
authors.forename: Mengrou
authors.initials: M
authors.lastname: Ren
authors.affiliation: Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
authors.forename: Guoren
authors.initials: G
authors.lastname: Huang
authors.affiliation: Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Key Laboratory of Zoonosis Research Ministry of Education, Jilin University, Changchun, Jilin 130062, People's Republic of China. Electronic address: xumingdeng@jluhp.edu.cn.
authors.forename: Xuming
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Food Quality and Safety, Jilin University, Changchun, Jilin 130062, People's Republic of China; Key Laboratory of Zoonosis Research Ministry of Education, Jilin University, Changchun, Jilin 130062, People's Republic of China. Electronic address: gshuang1973@126.com.
authors.forename: Shuang
authors.initials: S
authors.lastname: Guan
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism*; D000284:Administration, Oral; D000818:Animals; D050356:Lipid Metabolism / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D065626:Non-alcoholic Fatty Liver Disease / Q000139:chemically induced* / Q000201:enzymology; D015398:Signal Transduction / Q000187:drug effects; D059550:Toxicity Tests, Subchronic; D000517:alpha-Chlorohydrin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity
chemical_list: C033489:1,3-dichloro-2-propanol; D000517:alpha-Chlorohydrin; D000263:Adenylate Kinase
keywords: 1,3-DCP; AMPK; NAFLD; Subchronic toxicity