title: A case of acute fibrinous and organizing pneumonia during early postoperative period after lung transplantation.
abstract: Acute fibrinous and organizing pneumonia (AFOP) is a distinct histologic pattern usually classified under the term chronic lung allograft dysfunction. We present a 48-year-old female patient who experienced AFOP during the 2nd week of double lung transplantation for pulmonary Langerhans cell histiocytosis and secondary pulmonary hypertension. During the 8th day after transplantation, fever and neutrophilia developed together with bilateral consolidation. Infection markers were elevated. Despite coverage of a full antimicrobial spectrum, the situation progressed. The patient was diagnosed with AFOP with transbronchial biopsy. The infiltration resolved and the patient improved dramatically with the initiation of pulse corticosteroid treatment. AFOP should be suspected when there is a pulmonary consolidation after lung transplantation, even in the very early post-transplantation period. Several causes, such as alveolar damage and drug reactions, should be considered in the differential diagnosis.
authors.affiliation: Thoracic Surgery and Lung Transplantation Center, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey. Electronic address: ioalici@hotmail.com.
authors.forename: I O
authors.initials: IO
authors.lastname: Alici
authors.affiliation: Thoracic Surgery and Lung Transplantation Center, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Yekeler
authors.affiliation: Thoracic Surgery and Lung Transplantation Center, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Yazicioglu
authors.affiliation: Thoracic Surgery and Lung Transplantation Center, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Turan
authors.affiliation: Thoracic Surgery and Lung Transplantation Center, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Tezer-Tekce
authors.affiliation: Department of Pathology, Ataturk Chest Diseases and Thoracic Surgery Education and Research Hospital, Ankara, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Demirag
authors.affiliation: Thoracic Surgery and Lung Transplantation Center, Turkiye Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Karaoglanoglu
mesh_terms: D018450:Disease Progression; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D005355:Fibrosis; D006084:Graft Rejection; D006801:Humans; D008168:Lung / Q000473:pathology; D016040:Lung Transplantation / Q000009:adverse effects; D008875:Middle Aged; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D011184:Postoperative Period; D020551:Pulse Therapy, Drug; D011859:Radiography