title: Studies on the alkaloids of the calycanthaceae and their syntheses.
abstract: Plants of the Calycanthaceae family, which possesses four genera and about 15 species, are mainly distributed in China, North America and Australia. Chemical studies on the Calycanthaceae have led to the discovery of about 14 alkaloids of different skeletons, including dimeric piperidinoquinoline, dimeric pyrrolidinoindoline and/or trimeric pyrrolidinoindolines, which exhibit significant anti-convulsant, anti-fungal, anti-viral analgesic, anti-tumor, and anti-melanogenesis activities. As some of complex tryptamine-derived alkaloids exhibit promising biological activities, the syntheses of these alkaloids have also been a topic of interest in synthetic chemistry during the last decades. This review will focus on the structures and total syntheses of these alkaloids.
authors.affiliation: Chemical Biology Center, Lishui Institute of Agricultural Sciences, 827 Liyang Street, Lishui 323000, Zhejiang, China. xujinbiao2015@126.com.
authors.forename: Jin-Biao
authors.initials: JB
authors.lastname: Xu
authors.affiliation: Chemical Biology Center, Lishui Institute of Agricultural Sciences, 827 Liyang Street, Lishui 323000, Zhejiang, China. chengkejun@gmail.com.
authors.forename: Ke-Jun
authors.initials: KJ
authors.lastname: Cheng
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis* / Q000737:chemistry*; D053898:Biosynthetic Pathways; D031237:Calycanthaceae / Q000737:chemistry* / Q000378:metabolism*; D015394:Molecular Structure
chemical_list: D000470:Alkaloids