title: Amyloid beta-42 (Aβ-42), neprilysin and cytokine levels. A pilot study in patients with HIV related cognitive impairments.
abstract: HIV-associated dementia (HAD) is associated with amyloid-beta (Aβ) deposition. This study measured CSF and plasma amyloid beta-42 (Aβ-42), neprilysin (NEP) and cytokine levels in HIV-related cognitive impairments (HCI), HIV normal cognitive functioning (NF) and non-HIV controls. Our data showed a trend towards detectable plasma Aβ-42 levels more frequently in HCI (67%), when compared to NF (29%) and controls (10%). We showed elevated IL-8 levels in CSF of HCI compared to NF, although not significant values. The data from this pilot study indicates that CSF IL-8 and plasma Aβ-42 may be interesting biomarkers for the presence of HCI.
authors.affiliation: Department of Internal Medicine and Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Center, The Netherlands. Electronic address: Khutso.Mothapo@radboudumc.nl.
authors.forename: K M
authors.initials: KM
authors.lastname: Mothapo
authors.affiliation: Department of Virology, Radboud University Nijmegen Medical Center, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Stelma
authors.affiliation: Department of Medical Psychology, Radboud University Nijmegen Medical Center, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Janssen
authors.affiliation: Department of Medical Psychology, Radboud University Nijmegen Medical Center, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Kessels
authors.affiliation: Dementia Research Group, University of Bristol, Institute of Clinical Neurosciences, Level 1, Learning and Research, Southmead Hospital, Bristol, UK.
authors.forename: S
authors.initials: S
authors.lastname: Miners
authors.affiliation: Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
authors.forename: M M
authors.initials: MM
authors.lastname: Verbeek
authors.affiliation: Department of Internal Medicine and Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Center, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Koopmans
authors.affiliation: Department of Internal Medicine and Nijmegen Institute for Infection, Inflammation and Immunity, Radboud University Medical Center, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: van der Ven
mesh_terms: D000328:Adult; D016229:Amyloid beta-Peptides / Q000097:blood* / Q000134:cerebrospinal fluid; D003072:Cognition Disorders / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology; D016207:Cytokines / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000097:blood* / Q000134:cerebrospinal fluid; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000097:blood* / Q000134:cerebrospinal fluid; D010865:Pilot Projects; D019562:Viral Load; D055815:Young Adult
chemical_list: D016229:Amyloid beta-Peptides; D016207:Cytokines; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D015260:Neprilysin
keywords: Amyloid beta-42; Anti-inflammatory cytokines; HIV associated neurocognitive disorders; HIV related cognitive impairments; Neprilysin; Pro-inflammatory cytokines