title: Ultrasound-Guided Diffuse Optical Tomography for Predicting and Monitoring Neoadjuvant Chemotherapy of Breast Cancers: Recent Progress.
abstract: In this manuscript, we review the current progress of utilizing ultrasound-guided diffuse optical tomography (US-guided DOT) for predicting and monitoring neoadjuvant chemotherapy (NAC) outcomes of breast cancer patients. We also report the recent advance on optical tomography systems toward portable and robust clinical use at multiple clinical sites. The first patient who has been closely monitored before NAC, at day 2, day 8, end of first three cycles of NAC, and before surgery is given as an example to demonstrate the potential of US-guided DOT technique.
authors.affiliation: Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, USA Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
authors.forename: Chen
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
authors.forename: Hamed
authors.initials: H
authors.lastname: Vavadi
authors.affiliation: University of Connecticut Health Center, Farmington, CT, USA.
authors.forename: Alex
authors.initials: A
authors.lastname: Merkulov
authors.affiliation: Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, USA.
authors.forename: Hai
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Erfanzadeh
authors.affiliation: Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, USA.
authors.forename: Atahar
authors.initials: A
authors.lastname: Mostafa
authors.affiliation: Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, USA.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Gong
authors.affiliation: Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, USA.
authors.forename: Hassan
authors.initials: H
authors.lastname: Salehi
authors.affiliation: University of Connecticut Health Center, Farmington, CT, USA.
authors.forename: Susan
authors.initials: S
authors.lastname: Tannenbaum
authors.affiliation: Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, USA Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA zhu@engr.uconn.edu.
authors.forename: Quing
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy; D041622:Tomography, Optical / Q000379:methods*; D016896:Treatment Outcome; D016217:Ultrasonography, Mammary / Q000379:methods*
keywords: breast cancer treatment monitoring; dual-modalities; near infrared imaging; ultrasound; ultrasound-guided optical imaging