title: Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders.
abstract: Previously we designed a series of pyridinic anticholinesterasic compounds based on molecular hybridization between tacrine and the natural piperidine alkaloid (-)-3-O-acetylspectaline isolated from Senna spectabilis. Based on the information that the cholinergic system has an important role in the treatment of schizophrenia and depression, we herein report the evaluation of a series of pyridinic compounds in animal models for antipsychotic and antidepressant-like activities. Compound 2 decreased the immobility time of mice in the forced swimming test (5 and 10mg/kg p.o.) and prevented the climbing behavior induced by apomorphine (10mg/kg, p.o.), without impairing animals locomotor activity.
authors.affiliation: Departamento de Química Orgânica, Núcleo de Biossíntese, Bioensaios e Ecofisiologia de Produtos Naturais (NuBBE), Instituto de Química, Universidade Estadual Paulista, Araraquara, Brazil.
authors.forename: Marilia
authors.initials: M
authors.lastname: Valli
authors.affiliation: Laboratório de Psicofarmacologia Experimental, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Andresa Heemann
authors.initials: AH
authors.lastname: Betti
authors.affiliation: Departamento de Química, Instituto de Ciências Exatas, Naturais e Educação, Universidade Federal do Triângulo Mineiro, Uberaba, Brazil.
authors.forename: Amanda
authors.initials: A
authors.lastname: Danuello
authors.affiliation: Instituto de Química, Universidade Federal de Uberlândia, Uberlândia, Brazil.
authors.forename: Marcos
authors.initials: M
authors.lastname: Pivatto
authors.affiliation: Laboratório de Psicofarmacologia Experimental, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Centurião
authors.affiliation: Laboratório de Psicofarmacologia Experimental, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Camila Boque
authors.initials: CB
authors.lastname: Antonio
authors.affiliation: Laboratório de Psicofarmacologia Experimental, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Stela Maris Kuze
authors.initials: SM
authors.lastname: Rates
authors.affiliation: Departamento de Química Orgânica, Núcleo de Biossíntese, Bioensaios e Ecofisiologia de Produtos Naturais (NuBBE), Instituto de Química, Universidade Estadual Paulista, Araraquara, Brazil. Electronic address: bolzaniv@iq.unesp.br.
authors.forename: Vanderlan da Silva
authors.initials: Vda S
authors.lastname: Bolzani
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D002493:Central Nervous System Diseases / Q000188:drug therapy*; D004195:Disease Models, Animal; D051379:Mice; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012559:Schizophrenia / Q000188:drug therapy
chemical_list: D000928:Antidepressive Agents; D010880:Piperidines; D011725:Pyridines; C480880:spectaline
keywords: Antidepressant-like activity; Antipsychotic; Apomorphine-induced climbing; Forced swimming test; Pyridinic alkaloid analogs