title: Modern radiation therapy and potential fertility preservation strategies in patients with cervical cancer undergoing chemoradiation.
abstract: Young patients with cervical cancer who undergo chemoradiation might be interested in fertility preservation, not only dependent upon the use of a gestational carrier as maybe achieved by the use of ovarian transposition and cryo-conservation of oocytes or ovarian tissue, but may prefer to carry pregnancy to term after cancer treatment. The latter approach is a non-established concept needing both modern radiation therapy approaches as well as modifications -if at all possible- in current recommendations for target volume delineation to spare dose to the unaffected uterus. Future strategies to serve selected patients in this respect should only be conducted in prospective clinical evaluations and are critically discussed in this article.
authors.affiliation: Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. pirus.ghadjar@charite.de.
authors.forename: Pirus
authors.initials: P
authors.lastname: Ghadjar
authors.affiliation: Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. volker.budach@charite.de.
authors.forename: Volker
authors.initials: V
authors.lastname: Budach
authors.affiliation: Department of Gynecology, Charité Universitätsmedizin Berlin, Berlin, Germany. ch.koehler@asklepios.com.
authors.forename: Christhardt
authors.initials: C
authors.lastname: Köhler
authors.affiliation: Department of Gynecology, Charité Universitätsmedizin Berlin, Berlin, Germany. Dr.jantke@fera-berlin.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Jantke
authors.affiliation: Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. simone.marnitz@charite.de.
authors.forename: Simone
authors.initials: S
authors.lastname: Marnitz
mesh_terms: D059248:Chemoradiotherapy / Q000009:adverse effects*; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000628:therapy*