title: Use of functional near-infrared spectroscopy to evaluate the effects of anodal transcranial direct current stimulation on brain connectivity in motor-related cortex.
abstract: Transcranial direct current stimulation (tDCS) is a noninvasive, safe and convenient neuro-modulatory technique in neurological rehabilitation, treatment, and other aspects of brain disorders. However, evaluating the effects of tDCS is still difficult. We aimed to evaluate the effects of tDCS using hemodynamic changes using functional near-infrared spectroscopy (fNIRS). Five healthy participants were employed and anodal tDCS was applied to the left motor-related cortex, with cathodes positioned on the right dorsolateral supraorbital area. fNIRS data were collected from the right motor-related area at the same time. Functional connectivity (FC)between intracortical regions was calculated between fNIRS channels using a minimum variance distortion-less response magnitude squared coherence (MVDR-MSC) method. The levels of Oxy-HbO change and the FC between channels during the prestimulation, stimulation, and poststimulation stages were compared. Results showed no significant level difference, but the FC measured by MVDR-MSC significantly decreased during tDCS compared with pre-tDCS and post-tDCS, although the FC difference between pre-tDCS and post-tDCS was not significant. We conclude that coherence calculated from resting state fNIRS may be a useful tool for evaluating the effects of anodal tDCS and optimizing parameters for tDCS application.
authors.affiliation: Yanshan University, Institute of Electrical Engineering, No. 438, Hebei Street, Haigang District, Qinhuangdao 066004, China.
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Yan
authors.affiliation: Yanshan University, Institute of Electrical Engineering, No. 438, Hebei Street, Haigang District, Qinhuangdao 066004, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, No. 19, XinJieKouWai Street, HaiDian District, Beijing 100875, ChinacBeijing Normal University, Center for Collaboration an.
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, No. 19, XinJieKouWai Street, HaiDian District, Beijing 100875, ChinacBeijing Normal University, Center for Collaboration an.
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.affiliation: Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, No. 19, XinJieKouWai Street, HaiDian District, Beijing 100875, ChinacBeijing Normal University, Center for Collaboration an.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Beijing Normal University, State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, No. 19, XinJieKouWai Street, HaiDian District, Beijing 100875, ChinacBeijing Normal University, Center for Collaboration an.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Li
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D065908:Transcranial Direct Current Stimulation; D055815:Young Adult