title: Meta-analysis of comparison between self-expandable and balloon-expandable valves for patients having transcatheter aortic valve implantation.
abstract: Two different devices, 1 self-expanding and 1 balloon-expandable, have been developed for patients who underwent transcatheter aortic valve implantation with contrasting data about efficacy and safety. Pubmed, Medline, and Google Scholar were systematically searched for studies of these different devices, with data derived from randomized controlled trial or registries with multivariate analysis. All-cause death at 30 days and at follow-up were the primary end points, whereas postprocedural moderate or severe aortic regurgitation (AR), stroke, major vascular complications, bleedings, and pacemaker implantation the secondary ones. Six studies with 957 self-expanding and 947 balloon-expandable valves were included: 1 randomized controlled trial and 5 observational studies. At 30 days follow-up, rates of death did not differ between self-expanding and balloon-expandable valves (odds ratio [OR] 0.74, 95% confidence interval [CI] 0.47 to 1.17), whereas balloon expandable reduced rates of moderate or severe AR (OR 0.51, 95% CI 0.27 to 0.99) and of pacemaker implantation (OR 0.28, 95% CI 0.17 to 0.47). After a follow-up of 360 days (300 to 390), rates of all-cause death did not differ between the 2 groups. In conclusion, risks of moderate or severe AR and pacemaker implantation were lower with the balloon-expandable devices without an impact on 30 days and midterm mortality.
authors.affiliation: Division of Cardiology 1, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Moretti
authors.affiliation: Division of Cardiology 1, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: D'Ascenzo
authors.affiliation: Division of Cardiology, Istituto Humanitas, Milan, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Mennuni
authors.affiliation: Division of Cardiology 1, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy; Department of Cardiology, Assuit University Hospital, Assuit, Egypt. Electronic address: meshmeshaya11@yahoo.com.
authors.forename: Salma
authors.initials: S
authors.lastname: Taha
authors.affiliation: Department of Interventional Cardiology, Istituto Clinico S. Ambrogio, Milan, Italy.
authors.forename: Nedy
authors.initials: N
authors.lastname: Brambilla
authors.affiliation: Cardiology Department, University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Freek
authors.initials: F
authors.lastname: Nijhoff
authors.affiliation: Division of Cardiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Fraccaro
authors.affiliation: Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Barbanti
authors.affiliation: Cardiology Department, Ferrarotto Hospital, University of Catania, Catania, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Tamburino
authors.affiliation: Division of Cardiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tarantini
authors.affiliation: Division of Cardiology, Istituto Humanitas, Milan, Italy.
authors.forename: Marco L
authors.initials: ML
authors.lastname: Rossi
authors.affiliation: Division of Cardiology, Istituto Humanitas, Milan, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Presbitero
authors.affiliation: Division of Cardiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Napodanno
authors.affiliation: Cardiology Department, University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Pieter
authors.initials: P
authors.lastname: Stella
authors.affiliation: Department of Interventional Cardiology, Istituto Clinico S. Ambrogio, Milan, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Bedogni
authors.affiliation: Division of Cardiology 1, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Omedè
authors.affiliation: Division of Cardiology 2, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Conrotto
authors.affiliation: Division of Cardiology 1, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Montefusco
authors.affiliation: Division of Cardiology 1, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Giordana
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Biondi Zoccai
authors.affiliation: Cardiology Department, University Medical Center Utrecht, Utrecht, Netherlands.
authors.forename: Piefrancesco
authors.initials: P
authors.lastname: Agostoni
authors.affiliation: Division of Cardiology 2, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: D'Amico
authors.affiliation: Division of Cardiac Surgery, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Rinaldi
authors.affiliation: Division of Cardiology 2, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Marra
authors.affiliation: Division of Cardiology 1, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Gaita
mesh_terms: D001021:Aortic Valve / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D011474:Prosthesis Design; D065467:Transcatheter Aortic Valve Replacement / Q000295:instrumentation*