title: Customizing vaccines for melanoma.
abstract: A proof-of-principle study of three patients with advanced melanoma shows that personalized vaccines designed to target neoantigens unique to each patient's tumor provoke strong, diverse T-cell responses and are well tolerated.
mesh_terms: D019496:Cancer Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D017321:Clinical Trials, Phase I as Topic; D006801:Humans; D008545:Melanoma / Q000276:immunology* / Q000628:therapy*
chemical_list: D019496:Cancer Vaccines