title: High Viral Load and Respiratory Failure in Adults Hospitalized for Respiratory Syncytial Virus Infections.
abstract: A prospective study among adults hospitalized for polymerase chain reaction-confirmed respiratory syncytial virus infections (n = 123) showed frequent occurrence of lower respiratory-tract complications causing respiratory insufficiency (52.8%), requirement for assisted ventilation (16.3%), and intensive care unit admission/death (12.2%). High viral RNA concentration was detected at time of hospitalization, including in patients who presented later than 2 days of illness (day 1-2, 7.29 ± 1.47; day 3-4, 7.28 ± 1.41; day 5-8, 6.66 ± 1.87 log10 copies/mL). RNA concentration was independently associated with risk of complications and respiratory insufficiency (adjusted odds ratio 1.40 per log10 copies/mL increase, 95% confidence interval, 1.03-1.90; P = .034). Our data indicate the need and provide a basis for clinical research on antiviral therapy in this population.
authors.affiliation: Department of Medicine and Therapeutics Stanley Ho Centre for Emerging Infectious Diseases.
authors.forename: Nelson
authors.initials: N
authors.lastname: Lee
authors.affiliation: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR PRC.
authors.forename: Martin C W
authors.initials: MC
authors.lastname: Chan
authors.affiliation: Department of Medicine and Therapeutics.
authors.forename: Grace C Y
authors.initials: GC
authors.lastname: Lui
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Medicine and Therapeutics.
authors.forename: Rity Y K
authors.initials: RY
authors.lastname: Wong
authors.affiliation: Department of Medicine and Therapeutics.
authors.forename: Irene M H
authors.initials: IM
authors.lastname: Yung
authors.affiliation: Department of Medicine and Therapeutics.
authors.forename: Catherine S K
authors.initials: CS
authors.lastname: Cheung
authors.affiliation: Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR PRC.
authors.forename: Eugenia C Y
authors.initials: EC
authors.lastname: Chan
authors.affiliation: Department of Medicine and Therapeutics Stanley Ho Centre for Emerging Infectious Diseases.
authors.forename: David S C
authors.initials: DS
authors.lastname: Hui
authors.affiliation: Stanley Ho Centre for Emerging Infectious Diseases Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR PRC.
authors.forename: Paul K S
authors.initials: PK
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004196:Disease Outbreaks; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000453:epidemiology / Q000821:virology*; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000235:genetics / Q000302:isolation & purification*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000821:virology*; D012621:Seasons; D019562:Viral Load; D055815:Young Adult
chemical_list: D012367:RNA, Viral
keywords: RSV; respiratory failure; viral load