title: Forequarter amputation for recurrent breast cancer.
abstract: BACKGROUND
  Localized excision combined with radiation and chemotherapy represents the current standard of care for recurrent breast cancer. However, in certain conditions a forequarter amputation may be employed for these patients.
  
  
  METHODS
  We present a patient with recurrent breast cancer who had a complicated treatment history including multiple courses of chemotherapy, radiation, and local surgical excision. With diminishing treatment options, she opted for a forequarter amputation in an attempt to limit the spread of cancer.
  
  
  CONCLUSIONS
  In our patient the forequarter amputation was utilized as a last resort to slow disease progression after she had failed multiple rounds of chemotherapy and received maximal radiation. Unfortunately, while she had symptomatic relief in the short-term, she had cutaneous recurrence of metastatic adenocarcinoma within 2 months of the procedure. In comparing this case with other reported forequarter amputations, patients with non-metastatic disease showed a mean survival of approximately two years. Furthermore, among patients who had significant pain prior to surgery, all patients reported pain relief, indicating a significant palliative benefit. This seems to indicate that our patient's unfortunate outcome was anomalous compared to that of most patients undergoing forequarter amputation for recurrent breast cancer.
  
  
  CONCLUSIONS
  Forequarter amputation can be judiciously used for patients with recurrent or metastatic breast cancer. Patients with recurrent disease without evidence of distant metastases may be considered for curative amputation, while others may receive palliative benefit; disappointingly our patient achieved neither of these outcomes. In the long term, these patients may still have significant psychological problems.
authors.affiliation: Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, United States.
authors.forename: Krishna N
authors.initials: KN
authors.lastname: Pundi
authors.affiliation: Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, United States.
authors.forename: Yazan N
authors.initials: YN
authors.lastname: AlJamal
authors.affiliation: Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, United States.
authors.forename: Raaj K
authors.initials: RK
authors.lastname: Ruparel
authors.affiliation: Department of Surgery, Mayo Clinic College of Medicine, Rochester, MN, United States. Electronic address: farley.david@mayo.edu.
authors.forename: David R
authors.initials: DR
authors.lastname: Farley
keywords: Advanced cancer; Amputation; Breast; Forequarter; Metastatic; Recurrent cancer