title: Muscle extracellular matrix scaffold is a multipotent environment.
abstract: The multipotency of scaffolds is a new concept. Skeletal muscle acellular scaffolds (MAS) implanted at the interface of Tibialis Anterior/tibial bone and masseter muscle/mandible bone in a murine model were colonized by muscle cells near the host muscle and by bone-cartilaginous tissues near the host bone, thus highlighting the importance of the environment in directing cell homing and differentiation. These results unveil the multipotency of MAS and point to the potential of this new technique as a valuable tool in musculo-skeletal tissue regeneration.
authors.affiliation: 1. Section of Histology and Medical Embryology, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy ; 2. Calabrodental clinic, Biomedical Section, Maxillofacial Surgery Unit, Crotone, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Aulino
authors.affiliation: 1. Section of Histology and Medical Embryology, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy ; 3. Fondazione San Raffaele, Ceglie Messapica, Italy ; 4. Department of Surgery, McGowan Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Costa
authors.affiliation: 2. Calabrodental clinic, Biomedical Section, Maxillofacial Surgery Unit, Crotone, Italy.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Chiaravalloti
authors.affiliation: 2. Calabrodental clinic, Biomedical Section, Maxillofacial Surgery Unit, Crotone, Italy ; 5. UMR 8256 CNRS Biology of Adaptation and Aging, University Pierre et Marie Curie Paris 06, Paris, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Perniconi
authors.affiliation: 1. Section of Histology and Medical Embryology, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Adamo
authors.affiliation: 2. Calabrodental clinic, Biomedical Section, Maxillofacial Surgery Unit, Crotone, Italy ; 5. UMR 8256 CNRS Biology of Adaptation and Aging, University Pierre et Marie Curie Paris 06, Paris, France.
authors.forename: Dario
authors.initials: D
authors.lastname: Coletti
authors.affiliation: 2. Calabrodental clinic, Biomedical Section, Maxillofacial Surgery Unit, Crotone, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Marrelli
authors.affiliation: 2. Calabrodental clinic, Biomedical Section, Maxillofacial Surgery Unit, Crotone, Italy ; 6. Tecnologica Research Institute, Biomedical Section, Crotone, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Tatullo
authors.affiliation: 3. Fondazione San Raffaele, Ceglie Messapica, Italy ; 7. UTAPRAD-DIM, ENEA Frascati, Rome, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Teodori
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D005109:Extracellular Matrix / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D023421:Models, Animal; D039902:Multipotent Stem Cells / Q000166:cytology; D018482:Muscle, Skeletal / Q000166:cytology / Q000502:physiology*; D032448:Myoblasts, Skeletal / Q000166:cytology; D012038:Regeneration; D055153:Stem Cell Niche; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*
keywords: ECM scaffold; bone; cartilage; skeletal muscle; tissue engineering