title: Drug encapsulated polymeric microspheres for intracranial tumor therapy: A review of the literature.
abstract: Despite intensive surgical excision, radiation therapy, and chemotherapy, the current life expectancy for patients diagnosed with glioblastoma multiforme is only 12 to 15months. One of the approaches being explored to increase chemotherapeutic efficacy is to locally deliver chemotherapeutics encapsulated within degradable, polymeric microspheres. This review describes the techniques used to formulate drug encapsulated microspheres targeted for intracranial tumor therapy and how microsphere characteristics such as drug loading and encapsulation efficiency can be tuned based on formulation parameters. Further, the results of in vitro studies are discussed, detailing the varied drug release profiles obtained and validation of drug efficacy. Finally, in vivo results are summarized, highlighting the study design and the effectiveness of the drug encapsulated microspheres applied intracranially.
authors.affiliation: University of WA, Department of Chemical Engineering, Seattle, USA.
authors.forename: J Alaina
authors.initials: JA
authors.lastname: Floyd
authors.affiliation: University of WA, Department of Bioengineering, Seattle, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Galperin
authors.affiliation: University of WA, Department of Chemical Engineering, Seattle, USA; University of WA, Department of Bioengineering, Seattle, USA. Electronic address: ratner@uweb.engr.washington.edu.
authors.forename: Buddy D
authors.initials: BD
authors.lastname: Ratner
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D015195:Drug Design; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008863:Microspheres; D011108:Polymers / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers
keywords: 5-Fluorouracil; Chemotherapeutics; Drug delivery; Emulsion; Gliomas; Localized therapy; Microspheres; Paclitaxel