title: Jumping translocations, a novel finding in chronic lymphocytic leukaemia.
abstract: A jumping translocation (JT) is a rare cytogenetic aberration that can occur in haematological malignancy. It involves the translocation of the same fragment of donor chromosome onto two or more recipient chromosomes, typically in different cells. In this study, we describe the first series of chronic lymphocytic leukaemia (CLL) patients with JTs reported to date. Following a review of 878 CLL patient karyotypes, we identified 26 patients (3%) with 97 JTs. The most commonly occurring breakpoint in these translocations was 17p11.2. Loss of TP53 was identified prior to or at the same time as JT in 23 of 26 patients (88%). All patients eventually developed a complex karyotype. All but one patient has required treatment for CLL, with estimated median time to treatment of 11·5 months. This study establishes JTs as a recurrent abnormality found in CLL patients with aggressive disease. JTs contribute to complex karyotypes and, in many cases, are involved in chromosomal rearrangements that result in loss of the tumour suppressor gene TP53.
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.|Division of Medical Laboratory Science, School of Health and Rehabilitation, The Ohio State University, Columbus, OH, USA.
authors.forename: Cecelia R
authors.initials: CR
authors.lastname: Miller
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Deborah
authors.initials: D
authors.lastname: Stephens
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Ruppert
authors.affiliation: Department of Pathology, The Ohio State University, Columbus, OH, USA.
authors.forename: Frederick
authors.initials: F
authors.lastname: Racke
authors.affiliation: Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: McFaddin
authors.affiliation: Department of Pathology, The Ohio State University, Columbus, OH, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Breidenbach
authors.affiliation: Division of Medical Laboratory Science, School of Health and Rehabilitation, The Ohio State University, Columbus, OH, USA.
authors.forename: Huey-Jen
authors.initials: HJ
authors.lastname: Lin
authors.affiliation: Division of Medical Laboratory Science, School of Health and Rehabilitation, The Ohio State University, Columbus, OH, USA.
authors.forename: Kathy
authors.initials: K
authors.lastname: Waller
authors.affiliation: Division of Medical Laboratory Science, School of Health and Rehabilitation, The Ohio State University, Columbus, OH, USA.
authors.forename: Tammy
authors.initials: T
authors.lastname: Bannerman
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Jones
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Woyach
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Andritsos
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Kami
authors.initials: K
authors.lastname: Maddocks
authors.affiliation: Department of Pathology, The Ohio State University, Columbus, OH, USA.
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Department of Pathology, The Ohio State University, Columbus, OH, USA.
authors.forename: Gerard
authors.initials: G
authors.lastname: Lozanski
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Flynn
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Grever
authors.affiliation: Division of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.|Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.|Division of Medicinal Chemistry, College of Pharmacy, The Ohio State University, Columbus, OH, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Byrd
authors.affiliation: Department of Pathology, The Ohio State University, Columbus, OH, USA.
authors.forename: Nyla A
authors.initials: NA
authors.lastname: Heerema
mesh_terms: D000328:Adult; D000368:Aged; D056905:Chromosome Breakpoints; D002886:Chromosomes, Human, Pair 17; D005260:Female; D016158:Genes, p53; D006801:Humans; D059785:Karyotype; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014178:Translocation, Genetic
keywords: TP53; cancer cytogenetics; chromosomal rearrangement; chronic lymphocytic leukaemia; complex karyotype