title: Molybdopterin biosynthesis-Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP.
abstract: The first step in the biosynthesis of the molybdopterin cofactor involves an unprecedented insertion of the purine C8 carbon between the C2' and C3' carbons of the ribose moiety of GTP. Here we review mechanistic studies on this remarkable transformation. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications.
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, TX 77843, United States.
authors.forename: Angad P
authors.initials: AP
authors.lastname: Mehta
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, TX 77843, United States; Therapeutical Chemistry Department, National Research Center, Dokki, Cairo, Egypt.
authors.forename: Sameh H
authors.initials: SH
authors.lastname: Abdelwahed
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, TX 77843, United States. Electronic address: begley@chem.tamu.edu.
authors.forename: Tadhg P
authors.initials: TP
authors.lastname: Begley
mesh_terms: D055162:Biocatalysis; D002244:Carbon; D003067:Coenzymes / Q000096:biosynthesis*; D029968:Escherichia coli Proteins / Q000502:physiology*; D006160:Guanosine Triphosphate / Q000737:chemistry*; D006801:Humans; D007535:Isomerases / Q000502:physiology*; D008667:Metalloproteins / Q000096:biosynthesis*; D000090006:Molybdenum Cofactors; D011621:Pteridines; D011687:Purines / Q000737:chemistry*; D012266:Ribose / Q000737:chemistry*
chemical_list: D002244:Carbon; D003067:Coenzymes; D029968:Escherichia coli Proteins; D006160:Guanosine Triphosphate; D007535:Isomerases; D008667:Metalloproteins; D000090006:Molybdenum Cofactors; D011621:Pteridines; D011687:Purines; D012266:Ribose; C022261:molybdopterin; C000597949:MoaA protein, E coli; C030985:purine
keywords: Intermediate trapping; Mechanism; MoaA; Molybtopterin; Substrate analog