title: A concise formal total synthesis of lactimidomycin.
abstract: A formal total synthesis of the cytotoxic natural product lactimidomycin has been achieved in nine steps from (E)-2-methyl-2-pentenoic acid. The 12-membered lactone was efficiently formed via a copper-catalyzed ene-yne coupling/alkyne reduction tandem reaction.
authors.affiliation: Department of Chemistry, Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, MN 55414, USA. Georg@umn.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Gunda I
authors.initials: GI
authors.lastname: Georg
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D010881:Piperidones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D018942:Macrolides; D010881:Piperidones; C077633:lactimidomycin