title: Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment.
abstract: Proinflammatory cytokines are key inflammatory mediators in periodontitis. This study aimed to investigate the relationship between proinflammatory cytokines in saliva and periodontal status. To investigate the usefulness of cytokines in the therapeutic approach for periodontal disease, the relationship between stimulated cytokine changes and the periodontitis treatment outcome was investigated in this study. Saliva was obtained from 22 patients diagnosed by dentists as having chronic periodontitis. The proinflammatory cytokine (interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), and tumor necrosis factor β (TNF-β)) levels were determined using a commercially available kit. The IL-1β and IL-6 levels increased, whereas the TNF-β levels decreased with the severity of periodontitis (4 mm pocket percentage). Poststimulation IL-1α, IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome. The differences of IL-6 levels (cut point: 0.05 μg/g) yielded a sensitivity and specificity of 90.0% and 81.82%, respectively, for predicting the periodontitis treatment outcome. Among the proinflammatory cytokines, stimulated IL-6 was an excellent marker for predicting the periodontitis treatment outcome.
authors.affiliation: Division of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan ; Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Kou-Gi
authors.initials: KG
authors.lastname: Shyu
authors.affiliation: Department of Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan ; Department of Emergency, Min-Sheng General Hospital, Taoyuan 330, Taiwan.
authors.forename: Cheuk-Sing
authors.initials: CS
authors.lastname: Choy
authors.affiliation: Department of Obstetrics and Gynecology, Min-Sheng General Hospital, Taoyuan 330, Taiwan.
authors.forename: Daniel Chung-Lang
authors.initials: DC
authors.lastname: Wang
authors.affiliation: Dental Department, Cathay General Hospital, Taipei 106, Taiwan.
authors.forename: Wei-Chen
authors.initials: WC
authors.lastname: Huang
authors.affiliation: Dental Department, Cathay General Hospital, Taipei 106, Taiwan.
authors.forename: Shyuan-Yow
authors.identifier: 0000-0002-1841-1049
authors.initials: SY
authors.lastname: Chen
authors.affiliation: Dental Department, Cathay General Hospital, Taipei 106, Taiwan.
authors.forename: Chien-Hsun
authors.initials: CH
authors.lastname: Chen
authors.affiliation: School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Che-Tong
authors.initials: CT
authors.lastname: Lin
authors.affiliation: Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan ; Department of Cardiology, Cathay General Hospital, Taipei 106, Taiwan.
authors.forename: Chao-Chien
authors.initials: CC
authors.lastname: Chang
authors.affiliation: School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan.
authors.forename: Yung-Kai
authors.identifier: 0000-0002-4467-0300
authors.initials: YK
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D016207:Cytokines / Q000378:metabolism*; D003710:Demography; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000378:metabolism* / Q000628:therapy*; D012372:ROC Curve; D012307:Risk Factors; D012463:Saliva / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators