title: Effects of antibiotic treatment on the lactobacillus composition of vaginal microbiota.
abstract: We analyzed sensitivity of 123 vaginal lactobacillus strains to antibacterial substances. All lactobacillus strains were sensitive to ampicillin, cefazolin, cefotaxime, and vancomycin, and insensitive to metronidazole, trimethoprim/sulfamethoxazole, and levofloxacin. Lactobacillus strains demonstrated different sensitivity to gentamycin, clindamycin, erythromycin, ciprofloxacin, and tetracycline. The phenomenon of preferential selective influence of antibacterial drugs on the composition of lactobacilli of the vaginal microbiota, in which some lactobacilli survive as part of the vaginal microbiota and have a selective advantage over other types of lactobacilli, should be taken into account during treatment of vaginal infections and dysbiosis.
authors.affiliation: V. I. Kulakov Research Center for Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia, alinamelkumyan@yandex.ru.
authors.forename: A R
authors.initials: AR
authors.lastname: Melkumyan
authors.forename: T V
authors.initials: TV
authors.lastname: Priputnevich
authors.forename: A S
authors.initials: AS
authors.lastname: Ankirskaya
authors.forename: V V
authors.initials: VV
authors.lastname: Murav'eva
authors.forename: L A
authors.initials: LA
authors.lastname: Lubasovskaya
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D064307:Microbiota / Q000187:drug effects*; D011247:Pregnancy; D013752:Tetracycline / Q000494:pharmacology; D014621:Vagina / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002981:Clindamycin; D002939:Ciprofloxacin; D004917:Erythromycin; D013752:Tetracycline