title: [The effect of long-chain polyunsaturated ω-3 fatty acids on the arterial stiffness parameters in patients with diabetes mellitus type 2 and cardiovascular autonomic neuropathy].
abstract: OBJECTIVE
  To analyze the effect of long-chain (LC) polyunsaturated w-3 fatty acids (PUFAs) on the daily arterial stiffness parameters in patients with type 2 diabetes (DM2) and cardiovascular autonomic neuropathy (CAN).
  
  
  METHODS
  The study involved 39 patients with DM2 and verified functional stage of CAN. Patients were divided into 2 groups: therapy group (n=21) and control group (n=18). Patients of the control group received traditional hypoglycemic therapy; patients of the therapy group additionally received 1 capsule/day of the ω-3 PUFAs for three months.
  
  
  RESULTS
  The use of the ω-3 PUFAs resulted in a statistically significant decrease in aortic augmentation index (AAI) and pulse wave velocity in the aorta (PWV) during the active period. There was a decrease in AAI in the aorta and the brachial artery and in PWV in the aorta during the night.
  
  
  CONCLUSIONS
  The efficacy of ω-3-PUFAs is a result of a direct effect of the pharmacological agent on the circadian arterial stiffness parameters.
authors.affiliation: Danylo Halytsky National Medical University, Lviv, Ukraine.
authors.forename: V A
authors.initials: VA
authors.lastname: Serhiyenko
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness / Q000187:drug effects*
chemical_list: D015525:Fatty Acids, Omega-3