title: Chikungunya virus pathogenesis and immunity.
abstract: Chikungunya virus (CHIKV) is an arbovirus associated with acute and chronic arthralgia that re-emerged in the Indian Ocean islands in 2005-2006 and is currently responsible for the ongoing outbreaks in the Caribbean islands and the Americas. We describe here the acute and chronic clinical manifestations of CHIKV in patients that define the disease. We also review the various animal models that have been developed to study CHIKV infection and pathology and further strengthened the understanding of the cellular and molecular mechanisms of CHIKV infection and immunity. A complete understanding of the immunopathogenesis of CHIKV infection will help develop the needed preventive and therapeutic approaches to combat this arbovirosis.
authors.affiliation: 1 University of La Reunion , GRI/IRG EA4517, and Centre Hospitalier Universitaire (CHU North Felix-Guyon), Saint-Denis, La Reunion, France .
authors.forename: Philippe
authors.initials: P
authors.lastname: Gasque
authors.forename: Therese
authors.initials: T
authors.lastname: Couderc
authors.forename: Marc
authors.initials: M
authors.lastname: Lecuit
authors.forename: Pierre
authors.initials: P
authors.lastname: Roques
authors.forename: Lisa F P
authors.initials: LF
authors.lastname: Ng
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D018925:Chemokines / Q000276:immunology*; D065632:Chikungunya Fever / Q000276:immunology* / Q000473:pathology / Q000635:transmission; D002646:Chikungunya virus / Q000276:immunology* / Q000502:physiology; D016207:Cytokines / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D015047:Zoonoses
chemical_list: D018925:Chemokines; D016207:Cytokines
keywords: Adaptive immunity; Chikungunya; Cytokines and chemokines; Inflammation; Innate immunity; Target cells