title: Tolerance of Lung Allografts Achieved in Nonhuman Primates via Mixed Hematopoietic Chimerism.
abstract: While the induction of transient mixed chimerism has tolerized MHC-mismatched renal grafts in nonhuman primates and patients, this approach has not been successful for more immunogenic organs. Here, we describe a modified delayed-tolerance-induction protocol resulting in three out of four monkeys achieving long-term lung allograft survival without ongoing immunosuppression. Two of the tolerant monkeys displayed stable mixed lymphoid chimerism, and the other showed transient chimerism. Serial biopsies and post-mortem specimens from the tolerant monkeys revealed no signs of chronic rejection. The tolerant recipients also exhibited T cell unresponsiveness and a lack of alloantibody. This is the first report of durable mixed chimerism and successful tolerance induction of MHC-mismatched lungs in primates.
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: M
authors.initials: M
authors.lastname: Tonsho
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: A
authors.initials: A
authors.lastname: Aoyama
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: S
authors.initials: S
authors.lastname: Boskovic
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: O
authors.initials: O
authors.lastname: Nadazdin
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: K
authors.initials: K
authors.lastname: Capetta
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: R-N
authors.initials: RN
authors.lastname: Smith
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: R B
authors.initials: RB
authors.lastname: Colvin
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: D H
authors.initials: DH
authors.lastname: Sachs
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: A B
authors.initials: AB
authors.lastname: Cosimi
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: J C
authors.initials: JC
authors.lastname: Madsen
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: G
authors.initials: G
authors.lastname: Benichou
authors.affiliation: MGH Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: J S
authors.initials: JS
authors.lastname: Allan
mesh_terms: D000818:Animals; D046528:Chimerism; D006410:Hematopoiesis; D016040:Lung Transplantation; D008252:Macaca fascicularis; D014184:Transplantation, Homologous
keywords: Animal models; basic (laboratory) research/science; lung transplantation/pulmonology; nonhuman primate; tolerance; translational research/science