title: Association of intracranial aneurysms and meningiomas: a case-control study.
abstract: OBJECTIVE
  The authors aimed to assess whether the prevalence of intracranial aneurysms in patients with intracranial meningiomas was higher than that in a healthy population.
  
  
  METHODS
  The authors performed a hospital-based case-control study of 300 patients with newly diagnosed intracranial meningiomas and 900 age- and sex-matched controls without a history of brain tumors to evaluate any associations between intracranial aneurysms and intracranial meningiomas. Unconditional multivariate logistic regression models were used for case-control comparisons.
  
  
  RESULTS
  Intracranial aneurysms were identified in 23 patients (7.7%) and 24 controls (2.7%; p < 0.001). There was a significant association between intracranial aneurysms and intracranial meningiomas (OR 2.913, 95% CI 1.613-5.261) and hypertension (OR 1.905, 95% CI 1.053-3.446). In a subgroup analysis of the patients with newly diagnosed intracranial meningiomas, there was a significant association between intracranial aneurysms and hypertension (OR 2.876, 95% CI 1.125-7.352) and tumor volume (OR 1.012, 95% CI 1.001-1.024). These patients were also more likely than controls to have other intracranial vascular diseases (p < 0.001), such as isolated occlusion of the intracranial vessels, excluding intracranial aneurysms.
  
  
  CONCLUSIONS
  The prevalence of intracranial aneurysms was higher in patients with intracranial meningiomas. Hypertension and tumor volume appear to be associated with the formation of intracranial aneurysms in these patients.
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do, Korea;|Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea;
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Cerebrovascular Center, Pohang Stroke and Spine Hospital, Pohang, Korea;
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do, Korea;|Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea;
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Han
authors.affiliation: Medical Research Collaborating Center and.
authors.forename: Soyeon
authors.initials: S
authors.lastname: Ahn
authors.affiliation: Medical Research Collaborating Center and.
authors.forename: Jaebong
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.
authors.forename: Jae Hyoung
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.
authors.forename: Byung Se
authors.initials: BS
authors.lastname: Choi
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do, Korea;|Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea;
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Bang
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do, Korea;|Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea;
authors.forename: Chae-Yong
authors.initials: CY
authors.lastname: Kim
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do, Korea;
authors.forename: Gyojun
authors.initials: G
authors.lastname: Hwang
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do, Korea;|Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea;
authors.forename: O-Ki
authors.initials: OK
authors.lastname: Kwon
authors.affiliation: Department of Neurosurgery, Seoul National University Bundang Hospital, Gyeonggi-do, Korea;|Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea;
authors.forename: Chang Wan
authors.initials: CW
authors.lastname: Oh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D002532:Intracranial Aneurysm / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged
keywords: DSA = digital subtraction angiography; MRA = MR angiography; hypertension; intracranial aneurysm; meningioma; oncology; prevalence; tumor volume