title: CCR5 Expression Levels in HIV-Uninfected Women Receiving Hormonal Contraception.
abstract: Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4(+) and CD8(+) T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P < .01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.
authors.affiliation: Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts.
authors.forename: Gaia
authors.initials: G
authors.lastname: Sciaranghella
authors.affiliation: Georgetown University Medical Center, Washington D.C.
authors.forename: Cuiwei
authors.initials: C
authors.lastname: Wang
authors.affiliation: Georgetown University Medical Center, Washington D.C.
authors.forename: Haihong
authors.initials: H
authors.lastname: Hu
authors.affiliation: Department of Medicine, Albert Einstein College of Medicine, Bronx Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Biology, New York University School of Medicine, New York.
authors.forename: Zaher
authors.initials: Z
authors.lastname: Merhi
authors.affiliation: Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles.
authors.forename: Marek
authors.initials: M
authors.lastname: Nowicki
authors.affiliation: Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles.
authors.forename: Frank Z
authors.initials: FZ
authors.lastname: Stanczyk
authors.affiliation: Department of Clinical Pharmacy, University of California, San Francisco Department of Medicine, University of California, San Francisco Department of Biostatistics, University of California, San Francisco Department of Epidemiology, University of California, San Francisco.
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Greenblatt
authors.affiliation: Department of Medicine, Stroger Hospital Department of Medicine, Rush University CORE Center, Chicago, Illinois.
authors.forename: Mardge
authors.initials: M
authors.lastname: Cohen
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore.
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Golub
authors.affiliation: The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
authors.forename: D Heather
authors.initials: DH
authors.lastname: Watts
authors.affiliation: Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts.
authors.forename: Galit
authors.initials: G
authors.lastname: Alter
authors.affiliation: Georgetown University Medical Center, Washington D.C.
authors.forename: Mary A
authors.initials: MA
authors.lastname: Young
authors.affiliation: Brigham and Women's Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts.
authors.forename: Athe M N
authors.initials: AM
authors.lastname: Tsibris
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D003267:Contraception; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage*; D004522:Educational Status; D005260:Female; D018023:HIV Seronegativity; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage*; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage*; D019713:Receptors, CCR5 / Q000235:genetics / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000235:genetics / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000378:metabolism
chemical_list: C584933:CCR5 protein, human; C527276:CXCR4 protein, human; D003277:Contraceptives, Oral, Combined; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D016912:Levonorgestrel; D017258:Medroxyprogesterone Acetate
keywords: CCR5; CD4; CXCR4; HIV-1; hormonal contraception; levonorgestrel; medroxyprogesterone acetate; oral contraceptive pills; peripheral blood mononuclear cells