title: New beam monitoring tool for radiobiology experiments at the cyclotron ARRONAX.
abstract: The ARRONAX cyclotron is able to deliver alpha particles at 68 MeV. In the frame of radiological research, a new method is studied to infer in situ the deposited dose: it is based on the online measurement of the bremsstrahlung (>1 keV) produced by the interaction of the incident particle with the medium. Experiments are made using bombarded poly(methyl methacrylate) (PMMA)-equivalent water targets in order to characterise this continuous X-ray spectrum. The intensity of the bremsstrahlung spectrum allows for the beam monitoring. A simulation code of the bremsstrahlung has been built, and a good agreement is found with the experimental spectra. With this simulation, it is possible to predict the sensibility of this method: it varies with the target thickness, showing a good sensibility for thin target (<1000 µm) and saturation for thicker ones. Bremsstrahlung spectrum also shows a sensibility on the target's chemical composition.
authors.affiliation: GIP ARRONAX, Saint Herblain, France.
authors.forename: L
authors.initials: L
authors.lastname: Schwob
authors.affiliation: GIP ARRONAX, Saint Herblain, France SUBATECH, Ecole des Mines de Nantes, CNRS/IN2P3, Université de Nantes, Nantes charbel.koumeir@subatech.in2p3.fr.
authors.forename: C
authors.initials: C
authors.lastname: Koumeir
authors.affiliation: SUBATECH, Ecole des Mines de Nantes, CNRS/IN2P3, Université de Nantes, Nantes.
authors.forename: N
authors.initials: N
authors.lastname: Servagent
authors.affiliation: INSERM, CRCNA, Nantes, France.
authors.forename: M
authors.initials: M
authors.lastname: Cherel
authors.affiliation: SUBATECH, Ecole des Mines de Nantes, CNRS/IN2P3, Université de Nantes, Nantes.
authors.forename: A
authors.initials: A
authors.lastname: Guertin
authors.affiliation: GIP ARRONAX, Saint Herblain, France SUBATECH, Ecole des Mines de Nantes, CNRS/IN2P3, Université de Nantes, Nantes.
authors.forename: F
authors.initials: F
authors.lastname: Haddad
authors.affiliation: SUBATECH, Ecole des Mines de Nantes, CNRS/IN2P3, Université de Nantes, Nantes.
authors.forename: V
authors.initials: V
authors.lastname: Métivier
authors.affiliation: GIP ARRONAX, Saint Herblain, France SUBATECH, Ecole des Mines de Nantes, CNRS/IN2P3, Université de Nantes, Nantes.
authors.forename: N
authors.initials: N
authors.lastname: Michel
authors.affiliation: GIP ARRONAX, Saint Herblain, France SUBATECH, Ecole des Mines de Nantes, CNRS/IN2P3, Université de Nantes, Nantes.
authors.forename: F
authors.initials: F
authors.lastname: Poirier
authors.affiliation: SUBATECH, Ecole des Mines de Nantes, CNRS/IN2P3, Université de Nantes, Nantes.
authors.forename: A
authors.initials: A
authors.lastname: Rahmani
authors.affiliation: GIP ARRONAX, Saint Herblain, France Institut de Cancérologie de L'Ouest (ICO-R. Gauducheau), Saint Herblain, France.
authors.forename: N
authors.initials: N
authors.lastname: Varmenot
mesh_terms: D000512:Alpha Particles; D003198:Computer Simulation; D017357:Cyclotrons / Q000295:instrumentation*; D008962:Models, Theoretical; D009010:Monte Carlo Method; D017785:Photons; D019904:Polymethyl Methacrylate / Q000737:chemistry / Q000528:radiation effects*; D011853:Radiobiology; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation*; D014965:X-Rays
chemical_list: D019904:Polymethyl Methacrylate