title: Effects of administration of omega-3 fatty acids with or without vitamin E supplementation on adiponectin gene expression in PBMCs and serum adiponectin and adipocyte fatty acid-binding protein levels in male patients with CAD.
abstract: OBJECTIVE
  Adiponectin is a unique anti-atherogenic adipocytokine. Regulation of adiponectin secretion is dysfunctional in cardiovascular diseases. The current trial study assessed the effects of omega-3 fatty acids with or without vitamin E on adiponectin gene expression in peripheral blood mononuclear cells and serum adiponectin and adipocyte fatty acid-binding protein (A-FABP; also called ap2 and FABP4) levels in patients with coronary artery disease (CAD).
  
  
  METHODS
  This randomized, double-blind, placebo-controlled trial included 67 male patients with CAD. First of the four group of participants received 4 g/day omega-3 fatty acids plus 400 IU/day vitamin E (OE), second group 4 g/day omega-3 fatty acids plus vitamin E placebo (OP), or both omega-3 fatty acid and vitamin E placebos (PP) for 8 weeks. Adiponectin gene expression and serum adiponectin and FABP4 levels were evaluated.
  
  
  RESULTS
  The combination of omega-3 fatty acids and vitamin E in patients with CAD affected their serum adiponectin and FABP4 levels and the adiponectin/FABP4 ratio significantly. In the OP group, serum adiponectin levels did not change significantly. Consumption of omega-3 fatty acids with and without vitamin E had no significant effect on adiponectin gene expression.
  
  
  CONCLUSIONS
  Omega-3 fatty acids with or without vitamin E improve adiponectin levels in patients, without any significant changes in adiponectin gene expression. This nutritional intervention may prevent complications in patients with CAD because of increased adiponectin levels.
authors.affiliation: Department of Molecular and Cellular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences; Tehran-Iran; Department of Basic sciences and Nutrition, Faculty of Health, Mazandaran University of Medical Sciences; Sari-Iran. mjalali87@yahoo.com.
authors.forename: Atena
authors.initials: A
authors.lastname: Ramezani
authors.forename: Fariba
authors.initials: F
authors.lastname: Koohdani
authors.forename: Abolghasem
authors.initials: A
authors.lastname: Djazayeri
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Nematipour
authors.forename: Seyed Ali
authors.initials: SA
authors.lastname: Keshavarz
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Saboor Yaraghi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Eshraghian
authors.forename: Abbas
authors.initials: A
authors.lastname: Yousefinejad
authors.forename: Hassan
authors.initials: H
authors.lastname: Javanbakht
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Zarei
authors.forename: Sanaz
authors.initials: S
authors.lastname: Gholamhosseini
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Djalali
mesh_terms: D052242:Adiponectin / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy*; D019587:Dietary Supplements; D004311:Double-Blind Method; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015525:Fatty Acids, Omega-3; D014810:Vitamin E