title: Familial liability to schizophrenia and mood disorders and cognitive impairment in psychosis.
abstract: Schizophrenia and other psychoses are complex disorders with high rates of cognitive impairment and a considerable degree of genetic and environmental influence on its etiology. Whether cognitive impairment is related to dimensional scores of familial liability is still matter of debate. We conducted a cross-sectional study including 169 patients with psychotic disorders and 26 healthy controls. Attention, memory and executive functions were assessed, and familial loading scores for schizophrenia and mood disorders were calculated. The relationships between familial liability and neuropsychological performance were examined with Spearman׳s correlation coefficients. In addition, patients were classified into three groups by family loading tertiles, and comparisons were performed between the patients in the top and bottom tertiles. Low familial loading scores for schizophrenia showed a significant association with poor executive functioning and delayed visual memory. And these results were also achieved when the subset of psychotic patients in the two extreme tertiles of family loadings of schizophrenia and mood disorders were compared. Low familial liability to schizophrenia seems to be a contributing factor for the severity of cognitive impairment in patients with a broad putative schizophrenia spectrum diagnosis.
authors.affiliation: Psychiatric Department, Complejo Hospitalario de Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Spain. Electronic address: mcuestaz@cfnavarra.es.
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Cuesta
authors.affiliation: Psychiatric Department, Complejo Hospitalario de Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Spain. Electronic address: amalia.zarzuela.ituarte@cfnavarra.es.
authors.forename: Amalia
authors.initials: A
authors.lastname: Zarzuela
authors.affiliation: Psychiatric Department, Complejo Hospitalario de Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Spain; Department of Basic Psychology I, Faculty of Psychology, National Distance Education University (UNED), Madrid, Spain. Electronic address: am.sanchez.torres@navarra.es.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Sánchez-Torres
authors.affiliation: Psychiatric Department, Complejo Hospitalario de Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Spain; Department of Basic Psychology I, Faculty of Psychology, National Distance Education University (UNED), Madrid, Spain. Electronic address: rlorente_omenaca@hotmail.com.
authors.forename: Ruth
authors.initials: R
authors.lastname: Lorente-Omeñaca
authors.affiliation: Psychiatric Department, Complejo Hospitalario de Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Spain. Electronic address: lucia.moreno.izco@navarra.es.
authors.forename: Lucía
authors.initials: L
authors.lastname: Moreno-Izco
authors.affiliation: Spanish Mental Health Network (CIBERSAM), University of Valencia, Valencia, Spain; Clinic Hospital (INCLIVA), Valencia, Spain. Electronic address: julio.sanjuan@uv.es.
authors.forename: Julio
authors.initials: J
authors.lastname: Sanjuán
authors.affiliation: Psychiatric Department, Complejo Hospitalario de Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Spain. Electronic address: victor.peralta.martin@cfnavarra.es.
authors.forename: Victor
authors.initials: V
authors.lastname: Peralta
mesh_terms: D000328:Adult; D001288:Attention; D003072:Cognition Disorders / Q000235:genetics*; D003430:Cross-Sectional Studies; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008568:Memory; D019964:Mood Disorders / Q000235:genetics*; D011618:Psychotic Disorders / Q000150:complications / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D012720:Severity of Illness Index
keywords: Bipolar disorder; Cognitive functioning; Psychosis; Relatives; Schizophrenia