title: Secretion, blood levels and cutaneous expression of TL1A in psoriasis patients.
abstract: TL1A is a TNF-like cytokine which has been shown to co-stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is known about expression and induction in psoriasis. Indeed, the pathogenesis in psoriasis is still not fully understood and it is speculated that cytokines other than TNF-α are important in subsets of patients. Also, for patients with severe disease that are treated with systemic anti-TNF-α blockade, novel candidates to be used as disease and response biomarkers are of high interest. Here, we demonstrate TL1A expression in biopsies from psoriatic lesions. Also, we investigated spontaneous and induced TL1A secretion from PBMCs and blood levels from a cohort of psoriasis patients. Here, increased spontaneous secretion from PBMCs was observed as compared to healthy controls and a small subset of patients had highly elevated TL1A in the blood. Interestingly, activation of PBMCs with various cytokines showed a decreased sensitivity for TL1A activation in psoriasis patients compared to healthy controls.TL1A levels in blood and biopsies could not be correlated with disease activity with this patient cohort. Thus, additional large-scale studies are warranted to investigate TL1A as a biomarker.
authors.affiliation: Faculty of Health and Medical Sciences, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Anders Elm
authors.initials: AE
authors.lastname: Pedersen
authors.affiliation: Faculty of Health and Medical Sciences, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Esben Gjerløff Wedebye
authors.initials: EG
authors.lastname: Schmidt
authors.affiliation: Faculty of Health and Medical Sciences, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jesper Freddie
authors.initials: JF
authors.lastname: Sørensen
authors.affiliation: Faculty of Health and Medical Sciences, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Carsten
authors.initials: C
authors.lastname: Faber
authors.affiliation: Bioneer A/S, Hørsholm, Denmark.
authors.forename: Boye Schnack
authors.initials: BS
authors.lastname: Nielsen
authors.affiliation: Bioneer A/S, Hørsholm, Denmark.
authors.forename: Kim
authors.initials: K
authors.lastname: Holmstrøm
authors.affiliation: Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Silje Haukali
authors.initials: SH
authors.lastname: Omland
authors.affiliation: Faculty of Health and Medical Sciences, Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Tougaard
authors.affiliation: Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Søren
authors.initials: S
authors.lastname: Skov
authors.affiliation: Department of Dermatology, Bispebjerg University Hospital, Copenhagen, Denmark.
authors.forename: Bo
authors.initials: B
authors.lastname: Bang
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007150:Immunohistochemistry; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011565:Psoriasis / Q000097:blood*; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15 / Q000097:blood* / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; C117026:TNFSF15 protein, human; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15
keywords: LL37; TL1A; monocytes; psoriasis