title: Editor's Choice-Chest pain relief in patients with acute myocardial infarction.
abstract: Chest pain is the prevalent symptom at presentation in patients with acute myocardial infarction (AMI). Despite the complete absence of rigorous studies designed to assess the impact of morphine administration in patients with AMI, clinical practice guidelines strongly recommend morphine for analgesia. However, when using morphine to relieve chest pain in AMI patients, physicians must be aware that hypotension, respiratory depression, vomiting, and delayed onset of action of antiplatelet agents are potential unwanted side effects of the drug. The purpose of this report is to review morphine's clinical and side effects and to propose strategies able to reduce chest pain in AMI patients.
authors.affiliation: The Cardiovascular and Thoracic Department, Careggi Hospital, Florence, Italy The Post-graduate School in Cardiology, University of Florence, Italy parodiguido@gmail.com.
authors.forename: Guido
authors.initials: G
authors.lastname: Parodi
mesh_terms: D000700:Analgesics / Q000008:administration & dosage* / Q000627:therapeutic use; D002637:Chest Pain / Q000188:drug therapy*; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications*; D059408:Pain Management; D017410:Practice Guidelines as Topic
chemical_list: D000700:Analgesics
keywords: STEMI; antiplatelets; chest pain; morphine; myocardial infarction; prasugrel; ticagrelor