title: [Experimental comparative pharmacokinetics of levofloxacin, triazavirin, and related conjugate].
abstract: A comparative study of the pharmacokinetics of levofloxacin and triazavirine as well as 2-methylthio-6-nitro-1,2,4-triazolo[5,1-ñ]-1,2,4-triazine-7(4Í)-ide (3S)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-7H-pyrido[1,2,3-d,e]-1,4-benzoxazine-6-carboxylic acid (conjugate 2) obtained by conjugation of triazavirine and levofloxacin, representing a new class of pharmacological agents, was carried out in experiments on rats. It is established that conjugate 2 in comparison to individual levofloxacin and triazavirine has a higher relative bioavailability and lower rate of elimination, which can lead to improved effectiveness of therapy at reduced dose and frequency of drug administration.
authors.forename: I V
authors.initials: IV
authors.lastname: Blazhennikova
authors.forename: A F
authors.initials: AF
authors.lastname: Kurliakova
authors.forename: V N
authors.initials: VN
authors.lastname: Bykov
authors.forename: D S
authors.initials: DS
authors.lastname: Geĭbo
authors.forename: A S
authors.initials: AS
authors.lastname: Nikiforov
authors.forename: A V
authors.initials: AV
authors.lastname: Stepanov
authors.forename: V N
authors.initials: VN
authors.lastname: Charushin
authors.forename: O N
authors.initials: ON
authors.lastname: Chupakhin
authors.forename: S K
authors.initials: SK
authors.lastname: Kotovskaia
authors.forename: V L
authors.initials: VL
authors.lastname: Rusinov
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D001393:Azoles / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D002264:Carboxylic Acids / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D006207:Half-Life; D007273:Injections, Intramuscular; D064704:Levofloxacin / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D014227:Triazines / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D014230:Triazoles
chemical_list: D000890:Anti-Infective Agents; D001393:Azoles; D002264:Carboxylic Acids; D014227:Triazines; D014230:Triazoles; D064704:Levofloxacin; C539416:riamilovir