title: ﻿﻿﻿﻿Microbial cellulose wound dressing in the treatment of nonhealing lower extremity ulcers.
abstract: ﻿﻿﻿﻿﻿﻿﻿﻿﻿Following standard care, nonhealing lower extremity (LE) ulcers were managed with a bacterial cellulose (BC) wound dressing, Dermafill™, (AMD/Ritmed, Tonawanda, NY), derived from Acetobacter xylinum. The time to 75% reduction in wound size was compared in 11 chronic wounds before and after the application of BC. The mean period of observation before the application of BC was 315 days; (95% CI: 239-392 days). With the application of BC to these chronic wounds, the mean time to 75% epithelization was reduced to 81 days (95% CI: 50-111 days) with a median of 79 days. The rate of wound closure with BC was significantly faster than with standard care (P < 0.001). When applied to nonhealing LE ulcers, a BC wound dressing shortens the time to wound closure over standard care.
authors.forename: Orlando
authors.initials: O
authors.lastname: Portal
authors.forename: William A
authors.initials: WA
authors.lastname: Clark
authors.affiliation: Department of Medicine, Michael Reese Hospital, Chicago, Illinois; Email: djlevins@uic.edu.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Levinson