title: Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation.
abstract: In the absence of a steric directing group, iridium-catalyzed C-H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions. The functional group tolerance of the iridium-catalyzed C-H borylation reaction enables simple and efficient multidirectional syntheses of substituted indazoles to be realized.
authors.affiliation: †Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Sadler
authors.affiliation: †Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Hones
authors.affiliation: ‡Astra Zeneca, Alderley Park, Macclesfield SK10 4TF, U.K.
authors.forename: Bryan
authors.initials: B
authors.lastname: Roberts
authors.affiliation: §Pfizer-Neusentis, The Portway Building, Granta Park, Cambridge, CB21 6GS, U.K.
authors.forename: David
authors.initials: D
authors.lastname: Blakemore
authors.affiliation: †Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.|∥Institut für Anorganische Chemie, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany.
authors.forename: Todd B
authors.initials: TB
authors.lastname: Marder
authors.affiliation: †Department of Chemistry, Durham University, South Road, Durham DH1 3LE, U.K.
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Steel
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D006860:Hydrogen Bonding; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007495:Iridium / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001896:Boron Compounds; D007191:Indazoles; D007495:Iridium