title: Synthesis and evaluation of in vitro antioxidant properties of novel 2,5-disubstituted 1,3,4-oxadiazoles.
abstract: 2,5-Disubstituted 1,3,4-oxadiazole compounds are one of the most attractive heterocyclic compounds for researchers due to their biological activities. In the undertaken research, a number of potential 2,5-disubstituted 1,3,4-oxadiazole analogues were synthesized through multi step reaction and characterized by FT-IR, 1H NMR, mass spectra, and also by elemental analysis. Further benzophenone tagged indole acetohydrazides and 2,5-disubstituted 1,3,4-oxadiazoles were evaluated for antioxidant potential, through different in vitro models such as DPPH, nitric oxide and hydrogen peroxide methods. In the series of compounds some of them had shown good to moderate in vitro antioxidant potential compare to the standard drug ascorbic acid in all the above three methods.
authors.forename: V
authors.initials: V
authors.lastname: Lakshmi Ranganatha
authors.forename: Shaukath Ara
authors.initials: SA
authors.lastname: Khanum
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D001713:Biphenyl Compounds / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010851:Picrates / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D007211:Indoles; D010069:Oxadiazoles; D010851:Picrates; C583463:1,3,4-oxadiazole; D009569:Nitric Oxide; C030374:indole; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl