title: Bone regeneration of macropore octacalcium phosphate-coated deproteinized bovine bone materials in sinus augmentation: a prospective pilot study.
abstract: OBJECTIVE
  To investigate the osteogenic potential of macropore octacalcium phosphate (OCP)-coated deproteinized bovine bone materials (DBBMs) in sinus augmentation.
  
  
  METHODS
  Macropore OCP-coated DBBM was manufactured from bovine bone by thermal and chemical processing. Sinus grafts of a lateral window approach with experimental bone were conducted in 10 patients. At 6 months after surgery, a total of 10 specimens were obtained from 10 patients. But, 4 of them were excluded because the amount of specimens was not enough for evaluation. Morphological investigation under scanning electron microscopy and histological evaluation were performed.
  
  
  RESULTS
  OCP was evenly attached to the surface of the experimental graft and showed a relatively large pore size (300-400 μm) compared with Bio-Oss (100-200 μm). New bone comprised 23.49% (± 0.10), and residual graft material comprised 15.39% (± 0.06) in bone specimens.
  
  
  CONCLUSIONS
  A macropore-sized design and OCP coating could present a favorable environment for new bone formation in maxillary sinus grafts.
authors.affiliation: *Clinical Assistant Professor, Department of Oral and Maxillofacial Surgery, Asan Medical Center, Seoul, Korea. †Resident, Department of Oral and Maxillofacial Surgery, Seoul Asan Medical Center, Seoul, Korea. ‡Professor, Department of Oral and Maxillofacial Surgery, Asan Medical Center, Seoul, Korea.
authors.forename: Jee-Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Jin-Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Ju-Hong
authors.initials: JH
authors.lastname: Jeon
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D002417:Cattle; D003758:Dental Implantation, Endosseous / Q000379:methods*; D006801:Humans; D010865:Pilot Projects; D011446:Prospective Studies; D059546:Sinus Floor Augmentation / Q000379:methods*
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C022045:octacalcium phosphate