title: Detection of the plasmid-mediated quinolone resistance determinants in clinical isolates of Acinetobacter baumannii in China.
abstract: We examined the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants among Acinetobacter baumannii in Anhui, China. And β-lactamase genes and mutations in quinolone resistance-determining regions (QRDRs) were also investigated among the PMQR-positive isolates. Among the 39 A. baumannii isolates, 3 (7.7%) isolates harbored qnrB and 1 (2.6%) harbored qnrS. Mutations in the QRDRs of gyrA were identified in 2 isolates amongst the 4 PMQR-positive isolates. Quinolone resistance could be transferred by conjugation from all 4 PMQR-positive donors. In conclusion, more attention should be taken to prevent the transmission of PMQR genes among A. baumannii.
authors.affiliation: a Department of Infectious Disease , the First Affiliated Hospital of Anhui Medical University , Hefei , China.
authors.forename: Haifei
authors.initials: H
authors.lastname: Yang
authors.affiliation: b Institute of Bacterium Resistance , Anhui Medical University , Hefei , China.
authors.forename: Lifen
authors.initials: L
authors.lastname: Hu
authors.affiliation: b Institute of Bacterium Resistance , Anhui Medical University , Hefei , China.|c Anhui Center for Surveillance of Bacterial Resistance , Hefei , China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: a Department of Infectious Disease , the First Affiliated Hospital of Anhui Medical University , Hefei , China.|b Institute of Bacterium Resistance , Anhui Medical University , Hefei , China.|c Anhui Center for Surveillance of Bacterial Resistance , Hefei , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ye
authors.affiliation: a Department of Infectious Disease , the First Affiliated Hospital of Anhui Medical University , Hefei , China.|b Institute of Bacterium Resistance , Anhui Medical University , Hefei , China.|c Anhui Center for Surveillance of Bacterial Resistance , Hefei , China.|d Department of Infectious Disease , Chaohu Hospital of Anhui Medical University , Hefei , China.
authors.forename: Jiabin
authors.initials: J
authors.lastname: Li
mesh_terms: D000151:Acinetobacter Infections; D040981:Acinetobacter baumannii / Q000235:genetics*; D002681:China; D003227:Conjugation, Genetic; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D015363:Quinolones; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D015363:Quinolones; D001618:beta-Lactamases; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase
keywords: Acinetobacter baumannii; PMQR; QRDRs; QnrB; QnrS