title: Genetic variants in interleukin 7 receptor α chain (IL-7Ra) are associated with multiple sclerosis risk and disability progression in Central European Slovak population.
abstract: In this study, we determined the association between rs6897932 in interleukin 7 receptor α (IL7Ra) gene and the risk and disability progression of multiple sclerosis (MS) in 270 MS patients and 303 controls. We found allele C to be associated with the risk of MS and minor allele T to be protective against MS development. Moreover, we revealed for the first time that rs6897932 in IL7Ra gene is associated with the progression of MS, evaluated by MSSS scores. The minor allele T and genotype TT are protective against a rapid disability progression in MS in the Central European Slovak population.
authors.affiliation: Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Malá Hora 4, 036 01 Martin, Slovak Republic. Electronic address: dacierny@gmail.com.
authors.forename: Daniel
authors.initials: D
authors.lastname: Čierny
authors.affiliation: Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Malá Hora 4, 036 01 Martin, Slovak Republic. Electronic address: hanysova@jfmed.uniba.sk.
authors.forename: Sandra
authors.initials: S
authors.lastname: Hányšová
authors.affiliation: Department of Neurology, Jessenius Faculty of Medicine in Martin and Martin University Hospital, Comenius University in Bratislava, Kollárova 2, 036 59 Martin, Slovak Republic. Electronic address: michalik@unm.sk.
authors.forename: Jozef
authors.initials: J
authors.lastname: Michalik
authors.affiliation: Department of Neurology, Jessenius Faculty of Medicine in Martin and Martin University Hospital, Comenius University in Bratislava, Kollárova 2, 036 59 Martin, Slovak Republic. Electronic address: ema.kantorova@gmail.com.
authors.forename: Ema
authors.initials: E
authors.lastname: Kantorová
authors.affiliation: Department of Neurology, Jessenius Faculty of Medicine in Martin and Martin University Hospital, Comenius University in Bratislava, Kollárova 2, 036 59 Martin, Slovak Republic. Electronic address: egonkurca@gmail.com.
authors.forename: Egon
authors.initials: E
authors.lastname: Kurča
authors.affiliation: Department of Clinical Biochemistry, Jessenius Faculty of Medicine in Martin and Martin University Hospital, Comenius University in Bratislava, Kollárova 2, 036 59 Martin, Slovak Republic. Electronic address: molbiol@mfn.sk.
authors.forename: Mária
authors.initials: M
authors.lastname: Škereňová
authors.affiliation: Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Malá Hora 4, 036 01 Martin, Slovak Republic. Electronic address: lehotsky@jfmed.uniba.sk.
authors.forename: Ján
authors.initials: J
authors.lastname: Lehotský
mesh_terms: D000328:Adult; D006233:Persons with Disabilities; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D053699:Interleukin-7 Receptor alpha Subunit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000503:physiopathology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D018154:Slovakia
chemical_list: D053699:Interleukin-7 Receptor alpha Subunit
keywords: Disability progression; Gene polymorphism; IL7 receptor alpha gene; MSSS; Multiple sclerosis; rs6897932