title: Risk Factors for Recurrence of Periprosthetic Knee Infection.
abstract: We retrospectively reviewed 110 patients who underwent two-stage revision surgery in order to identify potential risk factors for recurrence of periprosthetic infection. We found that patients with inflammatory arthritis (P=0.0125), perioperative hematoma formation (P=0.0422), wound dehiscence (P=0.042), and those who are chronic Staphylococcus carriers (P=0.0177) were associated with an increased incidence of re-infection. The duration of intravenous antibiotic therapy less than 6 weeks was associated with a reduced risk of reinfection to greater than 6 weeks (P=0.03). Multivariate analysis indicated that wound dehiscence (odds ratio [OR], 5.119; 95% confidence interval [CI], 1.367-19.17), and Staphylococcus carriers (OR, 11.419; 95% CI, 1.376-94.727) are significant predictors of recurrence (P=0.0153 and 0.0241, respectively).
authors.affiliation: Department of Orthopedic Surgery, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York.
authors.forename: Vasileios I
authors.initials: VI
authors.lastname: Sakellariou
authors.affiliation: Department of Orthopedic Surgery, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York.
authors.forename: Lazaros A
authors.initials: LA
authors.lastname: Poultsides
authors.affiliation: Department of Orthopedic Surgery, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York.
authors.forename: Theofanis
authors.initials: T
authors.lastname: Vasilakakos
authors.affiliation: Department of Orthopedic Surgery, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York.
authors.forename: Peter
authors.initials: P
authors.lastname: Sculco
authors.affiliation: Department of Orthopedic Surgery, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Orthopedic Surgery, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Sculco
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007719:Knee Joint; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000209:etiology*; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000175:diagnosis*
keywords: infection; knee; periprosthetic; recurrence; two-stage