title: Long-term atorvastatin-ezetimibe-probucol triple therapy for homozygous familial hypercholesterolaemia from early childhood.
abstract: In this observational case report, we share our experience of achieving >40% LDL cholesterol reduction in four Chinese homozygous familial hypercholesterolaemia children below 8 years of age with a triple combination of atorvastatin, probucol, and ezetimibe for >6 years. Within a follow-up duration of 6-13 years, this triple therapy achieved significant reduction of LDL cholesterol as well as an impressive regression of xanthomas in all paediatric cases. All the children remained free from treatment-related adverse responses and cardiovascular events throughout follow-up.
authors.affiliation: 1Department of Cardiology,Second Xiangya Hospital,Central South University,Changsha,PR China.
authors.forename: Minjie
authors.initials: M
authors.lastname: Lin
authors.affiliation: 2Department of Urological Organ Transplantation,Center of Organ Transplantation,Second Xiangya Hospital,Central South University,Changsha,PR China.
authors.forename: Helong
authors.initials: H
authors.lastname: Dai
authors.affiliation: 1Department of Cardiology,Second Xiangya Hospital,Central South University,Changsha,PR China.
authors.forename: Shuiping
authors.initials: S
authors.lastname: Zhao
mesh_terms: D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D000069059:Atorvastatin / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D000069438:Ezetimibe / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006720:Homozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D011341:Probucol / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D000924:Anticholesteremic Agents; D000069059:Atorvastatin; D000069438:Ezetimibe; D011341:Probucol
keywords: Homozygous familial hypercholesterolaemia; LDL cholesterol; atherosclerotic cardiovascular disease; xanthoma