title: Correlation of the hypotonic shock response and extent of shape change with the new ThromboLUX ™.
abstract: ThromboLUX (TLX)-Score was compared with hypotonic shock response (HSR) and extent of shape change (ESC) in 99 samples from 42 platelet concentrates. Tests were performed in parallel and duplicate. Mean values for TLX Score, HSR and ESC were 30.3 ± 3.8%, 69.0 ± 12.2% and 23.2 ± 4.9%, respectively. We found no significant correlation between TLX Score and HSR or ESC (r = -0.158, P = 0.118 and r = -115, P = 0.255, respectively), whereas HSR and ESC correlated significantly (r = 0.351, P < 0.001). As TLX Score did not show significant correlation with HSR and ESC, the value of TLX for platelet quality testing remains unclear. Studies comparing these parameters with transfusion outcome are needed.
authors.affiliation: Department of Transfusion Medicine and Haemostaseology, University Hospital of Erlangen, Erlangen, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Kraemer
authors.affiliation: Department of Transfusion Medicine and Haemostaseology, University Hospital of Erlangen, Erlangen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Raczat
authors.affiliation: Department of Transfusion Medicine and Haemostaseology, University Hospital of Erlangen, Erlangen, Germany.
authors.forename: D R
authors.initials: DR
authors.lastname: Weiss
authors.affiliation: Department of Transfusion Medicine and Haemostaseology, University Hospital of Erlangen, Erlangen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Strobel
authors.affiliation: Department of Transfusion Medicine and Haemostaseology, University Hospital of Erlangen, Erlangen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Eckstein
authors.affiliation: Department of Transfusion Medicine and Haemostaseology, University Hospital of Erlangen, Erlangen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Ringwald
mesh_terms: D001792:Blood Platelets / Q000166:cytology / Q000502:physiology*; D001793:Blood Preservation / Q000009:adverse effects / Q000379:methods*; D048430:Cell Shape; D006801:Humans; D009997:Osmotic Pressure; D013312:Stress, Physiological
keywords: ThromboLUX; dynamic light scattering; extent of shape change; hypotonic shock response; platelet quality testing