title: Chromosome aberration model combining radiation tracks, chromatin structure, DSB repair and chromatin mobility.
abstract: The module that simulates the kinetics and yields of radiation-induced chromosome aberrations within the biophysical code PARTRAC is described. Radiation track structures simulated by Monte Carlo methods are overlapped with multi-scale models of DNA and chromatin to assess the resulting DNA damage. Spatial mobility of individual DNA ends from double-strand breaks is modelled simultaneously with their processing by the non-homologous end-joining enzymes. To score diverse types of chromosome aberrations, the joined ends are classified regarding their original chromosomal location, orientation and the involvement of centromeres. A comparison with experimental data on dicentrics induced by gamma and alpha particles shows that their relative dose dependence is predicted correctly, although the absolute yields are overestimated. The critical model assumptions on chromatin mobility and on the initial damage recognition and chromatin remodelling steps and their future refinements to solve this issue are discussed.
authors.affiliation: Institute of Radiation Protection, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Friedland
authors.affiliation: Institute of Radiation Protection, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany pavel.kundrat@helmholtz-muenchen.de.
authors.forename: P
authors.initials: P
authors.lastname: Kundrát
mesh_terms: D000512:Alpha Particles / Q000009:adverse effects*; D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics / Q000528:radiation effects; D002869:Chromosome Aberrations / Q000528:radiation effects*; D053903:DNA Breaks, Double-Stranded / Q000528:radiation effects*; D004260:DNA Repair / Q000528:radiation effects; D005720:Gamma Rays / Q000009:adverse effects*; D006801:Humans; D007700:Kinetics; D008962:Models, Theoretical; D009010:Monte Carlo Method
chemical_list: D002843:Chromatin