title: A review paper on biomimetic calcium phosphate coatings.
abstract: Biomimetic calcium phosphate coatings have been developed for bone regeneration and repair because of their biocompatibility, osteoconductivity, and easy preparation. They can be rendered osteoinductive by incorporating an osteogenic agent, such as bone morphogenetic protein 2 (BMP-2), into the crystalline lattice work in physiological situations. The biomimetic calcium phosphate coating enables a controlled, slow and local release of BMP-2 when it undergoes cell mediated coating degradation induced by multinuclear cells, such as osteoclasts and foreign body giant cells, which mimics a physiologically similar release mode, to achieve sustained ectopic or orthotopic bone formation. Therefore, biomimetic calcium phosphate coatings are considered to be a promising delivery vehicle for osteogenic agents. In this review, we present an overview of biomimetic calcium phosphate coatings including their preparation techniques, physico-chemical properties, potential as drug carrier, and their pre-clinical application both in ectopic and orthotopic animal models. We briefly review some features of hydroxyapatite coatings and their clinical applications to gain insight into the clinical applications of biomimetic calcium phosphate coatings in the near future.
authors.affiliation: Department of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands ; Department of Orthodontics, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China.
authors.forename: X
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: de Groot
authors.affiliation: Department of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Medical School, Nanjing University, Nanjing, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Department of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Wismeijer
authors.affiliation: Department of Oral Implantology, Academic Centre of Dentistry Amsterdam (ACTA), VU University and University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
keywords: Animal model; biomimetic; calcium phosphate coating; clinical application; drug delivery; hydroxyapatite; osseoconduction; osseoinduction; pre-clinical study