title: Evaluation of an open access software for calculating glucose variability parameters of a continuous glucose monitoring system applied at pediatric intensive care unit.
abstract: BACKGROUND
  Continuous Glucose Monitoring (CGM) has become an increasingly investigated tool, especially with regards to monitoring of diabetic and critical care patients. The continuous glucose data allows the calculation of several glucose variability parameters, however, without specific application the interpretation of the results is time-consuming, utilizing extreme efforts. Our aim was to create an open access software [Glycemic Variability Analyzer Program (GVAP)], readily available to calculate the most common parameters of the glucose variability and to test its usability.
  
  
  METHODS
  The GVAP was developed in MATLAB® 2010b environment. The calculated parameters were the following: average area above/below the target range (Avg. AUC-H/L); Percentage Spent Above/Below the Target Range (PATR/PBTR); Continuous Overall Net Glycemic Action (CONGA); Mean of Daily Differences (MODD); Mean Amplitude of Glycemic Excursions (MAGE). For verification purposes we selected 14 CGM curves of pediatric critical care patients. Medtronic® Guardian® Real-Time with Enlite® sensor was used. The reference values were obtained from Medtronic®(')s own software for Avg. AUC-H/L and PATR/PBTR, from GlyCulator for MODD and CONGA, and using manual calculation for MAGE.
  
  
  RESULTS
  The Pearson and Spearman correlation coefficients were above 0.99 for all parameters. The initial execution took 30 minutes, for further analysis with the Windows® Standalone Application approximately 1 minute was needed.
  
  
  CONCLUSIONS
  The GVAP is a reliable open access program for analyzing different glycemic variability parameters, hence it could be a useful tool for the study of glycemic control among critically ill patients.
authors.affiliation: First Department of Pediatrics, Semmelweis University, Bókay u. 53-54, Budapest, 1083, Hungary. marics.gabor@gmail.com.
authors.forename: Gábor
authors.initials: G
authors.lastname: Marics
authors.affiliation: First Department of Pediatrics, Semmelweis University, Bókay u. 53-54, Budapest, 1083, Hungary. zoisamail@gmail.com.
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Lendvai
authors.affiliation: First Department of Pediatrics, Semmelweis University, Bókay u. 53-54, Budapest, 1083, Hungary. lodi.csaba@med.semmelweis-univ.hu.
authors.forename: Csaba
authors.initials: C
authors.lastname: Lódi
authors.affiliation: MRE Bethesda Children's Hospital, Bethesda u. 3, Budapest, 1146, Hungary. matyasszajko@gmail.com.
authors.forename: Levente
authors.initials: L
authors.lastname: Koncz
authors.affiliation: First Department of Pediatrics, Semmelweis University, Bókay u. 53-54, Budapest, 1083, Hungary. david.zakarias@yahoo.com.
authors.forename: Dávid
authors.initials: D
authors.lastname: Zakariás
authors.affiliation: Department of Measurement and Automation, Kálmán Kandó Faculty of Electrical Engineering, Óbuda University, Bécsi út 96/B, Budapest, 1034, Hungary. schuster.gyorgy@kvk.uni-obuda.hu.
authors.forename: György
authors.initials: G
authors.lastname: Schuster
authors.affiliation: MRE Bethesda Children's Hospital, Bethesda u. 3, Budapest, 1146, Hungary. borbala.mikos@gmail.com.
authors.forename: Borbála
authors.initials: B
authors.lastname: Mikos
authors.affiliation: Department of Anesthesia and Intensive Care, Semmelweis University, Kútvölgyi út 4, Budapest, 1125, Hungary. indrhecs@gmail.com.
authors.forename: Csaba
authors.initials: C
authors.lastname: Hermann
authors.affiliation: First Department of Pediatrics, Semmelweis University, Bókay u. 53-54, Budapest, 1083, Hungary. szabo.attila@med.semmelweis-univ.hu.|MTA-SE Pediatrics and Nephrology Research Group, Bókay u. 53, Budapest, 1083, Hungary. szabo.attila@med.semmelweis-univ.hu.
authors.forename: Attila J
authors.initials: AJ
authors.lastname: Szabó
authors.affiliation: First Department of Pediatrics, Semmelweis University, Bókay u. 53-54, Budapest, 1083, Hungary. toth-heyn.peter@med.semmelweis-univ.hu.
authors.forename: Péter
authors.initials: P
authors.lastname: Tóth-Heyn
mesh_terms: D000465:Algorithms; D001774:Blood Chemical Analysis / Q000295:instrumentation; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D003199:Computer Systems; D016638:Critical Illness; D004377:Dumping Syndrome / Q000097:blood / Q000150:complications; D004867:Equipment Design; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D007003:Hypoglycemia / Q000097:blood* / Q000209:etiology; D015278:Intensive Care Units, Pediatric; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D066295:Open Access Publishing
chemical_list: D001786:Blood Glucose