title: Connectivity analysis of normal and mild cognitive impairment patients based on FDG and PiB-PET images.
abstract: Connectivity analysis allows researchers to explore interregional correlations, and thus is well suited for analysis of complex networks such as the brain. We applied whole brain connectivity analysis to assess the progression of Alzheimer's disease (AD). To detect early AD progression, we focused on distinguishing between normal control (NC) subjects and subjects with mild cognitive impairment (MCI). Fludeoxyglucose (FDG) and Pittsburgh compound B (PiB)-positron emission tomography (PET) were acquired for 75 participants. A graph network was implemented using correlation matrices. Correlation matrices of FDG and PiB-PET were combined into one matrix using a novel method. Group-wise differences between NC and MCI patients were assessed using clustering coefficients, characteristic path lengths, and betweenness centrality using various correlation matrices. Using connectivity analysis, this study identified important regions differentially affected by AD progression.
authors.affiliation: Department of Electronic Electrical and Computer Engineering, Sungkyunkwan University, Republic of Korea.
authors.forename: Seong-Jin
authors.initials: SJ
authors.lastname: Son
authors.affiliation: Department of Electronic Electrical and Computer Engineering, Sungkyunkwan University, Republic of Korea.
authors.forename: Jonghoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Yonsei University, Republic of Korea.
authors.forename: Jongbum
authors.initials: J
authors.lastname: Seo
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Republic of Korea.
authors.forename: Jong-min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: School of Electronic and Electrical Engineering, Sungkyunkwan University, Republic of Korea. Electronic address: hyunjinp@skku.edu.
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Park
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000523:psychology; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D019275:Radiopharmaceuticals; D013844:Thiazoles; D019788:Fluorodeoxyglucose F18
keywords: Connectivity analysis; FDG-PET; Mild cognitive impairment; PiB-PET