title: Intracellular angiotensin II disrupts chemical communication and impairs metabolic cooperation between cardiac myocytes.
abstract: The influence of intracellular angiotensin II (Ang II) on the process of chemical communication and metabolic cooperation between cardiac cells is discussed. Emphasis is given to the influence of pathological conditions like heart failure, myocardial ischemia or hyperglycemia on the activation of the intracrine renin angiotensin aldosterone system (RAAS) and its consequence for the metabolic cooperation between heart cells. Furthermore, the influence of high glucose on the process of chemical communication was described as well as its implication for the failing and diabetic heart. The major conclusion is that the activation of the intracrine renin angiotensin induced by heart failure, hyperglycemia, aldosterone or myocardial ischemia generates metabolic imbalance in the heart with serious consequences for the cardiac function.
authors.affiliation: School of Medicine, Medical Sciences Campus, UPR, San Juan, PR 00936, USA. Electronic address: walmor.de-mello@upr.edu.
authors.forename: Walmor C
authors.initials: WC
authors.lastname: De Mello
mesh_terms: D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D002450:Cell Communication; D006333:Heart Failure / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism* / Q000473:pathology; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D012084:Renin-Angiotensin System
chemical_list: D000804:Angiotensin II
keywords: Chemical communication; Heart cells; Intracellular angiotensin