title: Treatment of Oral Mucosal Lesions by Scalpel Excision and Platelet-Rich Fibrin Membrane Grafting: A Review of 26 Sites.
abstract: OBJECTIVE
  One of the preferred treatment options for oral mucosal lesions (eg, leukoplakia and lichen planus) is excision, with or without the use of a coverage agent. Platelet-rich fibrin (PRF) membranes are popular fibrin scaffolds with entrapped platelets that release various growth factors and cytokines to support and enhance wound healing. The aim of the present report was to describe the technique, postoperative wound care, and clinical results of PRF membrane grafting after excision of superficial potentially malignant oral lesions.
  
  
  METHODS
  Autologous PRF membrane was fabricated and grafted over 26 wounds created by excision of small, superficial, potentially malignant lesions of oral mucosa (or fiberotomy in cases of oral submucous fibrosis) and assessed clinically at 7, 15, 30, and 60 days.
  
  
  RESULTS
  Healing was satisfactory in all cases, with minimal and manageable complication at 1 site.
  
  
  CONCLUSIONS
  The results of the present study suggest that PRF membrane is a successful coverage agent that aids in the healing of superficial oral mucosal wounds. Additional comparative studies are required to establish its efficacy compared with that of other agents.
authors.affiliation: Postgraduate Third-year Student, Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India. Electronic address: drhimanipathak@gmail.com.
authors.forename: Himani
authors.initials: H
authors.lastname: Pathak
authors.affiliation: Professor and Head, Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India.
authors.forename: Sujata
authors.initials: S
authors.lastname: Mohanty
authors.affiliation: Professor and Head, Department of Oral Pathology and Microbiology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
authors.forename: Aadithya B
authors.initials: AB
authors.lastname: Urs
authors.affiliation: Senior Resident, Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, New Delhi, India.
authors.forename: Jitender
authors.initials: J
authors.lastname: Dabas
mesh_terms: D000328:Adult; D005260:Female; D005337:Fibrin; D006801:Humans; D007972:Leukoplakia, Oral / Q000601:surgery*; D017676:Lichen Planus, Oral / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000601:surgery*; D011446:Prospective Studies; D054457:Tissue Scaffolds; D055815:Young Adult
chemical_list: D005337:Fibrin