title: Magnetization transfer MRI in dementia disorders, Huntington's disease and parkinsonism.
abstract: Magnetic resonance imaging is the most used technique of neuroimaging. Using recent advances in magnetic resonance application it is possible to investigate several changes in neurodegenerative disease. Among different techniques, magnetization-transfer imaging (MTI), a magnetic resonance acquisition protocol assessing the magnetization exchange between protons bound to water and those bound to macromolecules, is able to identify microstructural brain tissue changes peculiar of neurodegenerative diseases. This review provides a report on the MTI technique and its use in the dementia disorders, Huntington's disease and parkinsonisms, comprehensive of the predictive values of MTI in the identification of early-phase disease.
authors.affiliation: Clinica Neurologica, Azienda Ospedaliera-Università di Perugia, Perugia, Italy. Electronic address: n.tambasco@libero.it.
authors.forename: Nicola
authors.initials: N
authors.lastname: Tambasco
authors.affiliation: Clinica Neurologica, Azienda Ospedaliera-Università di Perugia, Perugia, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Nigro
authors.affiliation: Clinica Neurologica, Azienda Ospedaliera-Università di Perugia, Perugia, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Romoli
authors.affiliation: Clinica Neurologica, Azienda Ospedaliera-Università di Perugia, Perugia, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Simoni
authors.affiliation: Clinica Neurologica, Azienda Ospedaliera-Università di Perugia, Perugia, Italy.
authors.forename: Lucilla
authors.initials: L
authors.lastname: Parnetti
authors.affiliation: Clinica Neurologica, Azienda Ospedaliera-Università di Perugia, Perugia, Italy; IRCCS Fondazione Santa Lucia, Roma, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabresi
mesh_terms: D003704:Dementia / Q000473:pathology*; D006801:Humans; D006816:Huntington Disease / Q000473:pathology*; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D020734:Parkinsonian Disorders / Q000473:pathology*
keywords: Dementia; Huntington's disease; MRI; Magnetic resonance imaging; Magnetization transfer; Parkinson's disease