Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging.
To develop carriers for anti-cancer drug delivery, this study reports a biocompatible and thermal responsive controlled drug delivery system based on hollow magnetic nanoparticles (HMNPs). The system is constructed simply by filling the hollow interiors of HMNPs with a phase-change material (PCM), namely, 1-tetradecanol, which has a melting point of 38 °C. The system achieves near "zero release" of both hydrophobic paclitaxel (PTX) and hydrophilic doxorubicin hydrochloride (DOX) and precise "on" or "off" drug delivery in vitro to efficiently induce cell apoptosis. Furthermore, the system displays both infrared thermal imaging and magnetic resonance imaging properties. More importantly, the system demonstrates great potential for thermo-chemo combination cancer therapy in vivo when an alternating magnetic field is applied.
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, PR China. kaiyong_cai@cqu.edu.cn.
Jinghua
J
Li
Yan
Y
Hu
Yanhua
Y
Hou
Xinkun
X
Shen
Gaoqiang
G
Xu
Liangliang
L
Dai
Jun
J
Zhou
Yun
Y
Liu
Kaiyong
K
Cai
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D056945:Hep G2 Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D018625:Microscopy, Atomic Force; D018613:Microscopy, Confocal; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000401:mortality; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D011859:Radiography; D015996:Survival Rate; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D004317:Doxorubicin; D017239:Paclitaxel