Pulvinulin A, graminin C, and cis-gregatin B--new natural furanones from Pulvinula sp. 11120, a fungal endophyte of Cupressus arizonica.
Three new natural furanones, pulvinulin A (1), graminin C (2), and cis-gregatin B (3), together with the known fungal metabolites, graminin B (4) and 10-norparvulenone (5), were isolated from Pulvinula sp. 11120, an endophytic fungal strain occurring in healthy foliage of Cupressus arizonica (Arizona cypress). The structures of 1 and 2 were elucidated by the analysis of their spectroscopic data and chemical interconversions, and that of 3 was determined by comparison with data for synthetic cis-gregatin B. Comparison of spectroscopic data of 4 and 5 with those reported identified them as graminin B and 10-norparvulenone, respectively. Metabolites 1-4 exhibited antibacterial activity against E. coli.
E M Kithsiri
EM
Wijeratne
Yaming
Y
Xu
A Elizabeth
AE
Arnold
A A Leslie
AA
Gunatilaka
D001203:Ascomycota / Q000737:chemistry* / Q000302:isolation & purification; D029781:Cupressus / Q000382:microbiology*; D060026:Endophytes / Q000737:chemistry* / Q000302:isolation & purification; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests
D005663:Furans; C000599433:graminin C; C559559:gregatin B; C000599432:pulvinulin A