Emerging properties of nuclear RNP biogenesis and export.
RNA biology has recently seen an explosion of data due to advances in RNA sequencing, proteomic, and RNA imaging technologies. In this review, we highlight progress that has been made using these approaches in the area of nuclear RNP biogenesis and export. Excitingly, the ability to collect quantitative data at the 'omics' scale combined with measurements of transcription, decay, and transport kinetics is providing the information needed to address RNP biogenesis at a systems level. We believe this to be a necessary and critical next step that will lead to a better understanding of how RNP quality, diversity, and fate emerge from a defined set of nuclear RNP assembly and maturation steps.
Institut de recherches cliniques de Montréal, 110 Avenue des Pins Ouest, Montréal, Québec, Canada H2W 1R7; Département de biochimie et médicine moléculaire, Université de Montréal, Montréal, Québec, Canada H3T 1J4; Faculty of Medicine, Division of Experimental Medicine, McGill University, Montréal, Québec, Canada H3A 1A3. Electronic address: marlene.oeffinger@ircm.qc.ca.
Marlene
M
Oeffinger
Department of Cell Biology, University of Alberta, 5-14 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7. Electronic address: ben.montpetit@ualberta.ca.
Ben
B
Montpetit
D000818:Animals; D006801:Humans; D021381:Protein Transport; D012313:RNA / Q000235:genetics; D016601:RNA-Binding Proteins / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism*
D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; D012313:RNA