Fractional epidermal grafting in combination with laser therapy as a novel approach in treating radiation dermatitis.
Radiation injury to the skin is a major source of dysfunction, disfigurement, and complications for thousands of patients undergoing adjunctive treatment for internal cancers. Despite the great potential for affecting quality of life, radiation injury has received little attention from dermatologists and is primarily being managed by radiation oncologists. During our volunteer work in Vietnam, we encountered numerous children with significant scarring and depigmentation of skin from the outdated use of radioactive phosphorus P32 in the treatment of hemangiomas. This dangerous practice has left thousands of children with significant fibrosis and disfigurement. Currently, there is no treatment for radiation dermatitis. Here, we report a case series using the combination of laser treatment, including pulsed-dye laser, fractional CO2 laser, and epidermal grafting to improve the appearance and function of the radiation scars in these young patients. We hope that by improving the appearance and function of these scars, we can improve the quality of life for these young patients and potentially open up a new avenue of treatment for cancer patients affected with chronic radiation dermatitis, potentially improving their range of motion, cosmesis, and reducing their risk of secondary skin malignancies.
Cutaneous Biology Research Center, Boston, Massachusetts, USA. ttran2@partners.org.
Thanh-Nga Trinh
TN
Tran
University of Medicine and Pharmacy, Ho Chi Minh City, Virtnam.
Minh Van
MV
Hoang
University of Medicine and Pharmacy, Ho Chi Minh City, Virtnam.
Quynh-Anh Ngoc
QA
Phan
Department of Pathology, Texas Children's Hospital, Houston, Texas, USA.
Thuy L
TL
Phung
Wellman Center for Photomedicine, Boston, Massachusetts, USA.
Martin
M
Purschke
Wellman Center for Photomedicine, Boston, Massachusetts, USA.
William A
WA
Ferinelli
SevenOaks Biosystems, Cambridge, Massachusetts, USA.
Sameer
S
Sabir
Catapult Product Development, Waltham, Massachusetts, USA.
Andrew
A
Ziegler
Beckman Laser Institute and Medical Clinic, Irvine, California, USA.
Stuart
S
Nelson
Wellman Center for Photomedicine, Boston, Massachusetts, USA.
R Rox
RR
Anderson
fractional CO2 laser; fractional epidermal grafting; pulsed-dye laser; radiation dermatitis; radiation fibrosis