Use of rhBMP-2/β-TCP for Interpositional Vertical Grafting Augmentation: 5.5-Year Follow-up Clinically and Histologically.
OBJECTIVE
This case report documented long-term results using rh-BMP-2/β-tricalcium phosphate (TCP) for vertical grafting augmentation.


METHODS
A 58-year-old patient with extreme atrophy of the left posterior mandible was treated with rh-BMP-2/β-TCP for vertical bone augmentation. At the time of implant placement, bone biopsy was performed for histological evaluation.


RESULTS
Seven months after surgery, CT scan demonstrated approximately 8 mm of bone gain height. The histological results revealed a newly formed vital bone tissue, predominantly lamellar with variable density. Remaining bone ceramic surrounded by newly formed bone tissue or connective tissue was observed. The bone levels remained unchanged during the entire period treatment (5.5 years).


CONCLUSIONS
This technique has demonstrated a potential for reconstruction of atrophic sites when vertical bone gain is desirable. Moreover, the bone gain has shown long-term maintenance without resorption. Future long-term prospective clinical trials are needed to confirm these findings.
*Private Practice, Department of Oral Implantology and Periodontics, Curitiba, Brazil. †Resident, Department of Implantology, São Leopoldo Mandic School of Dentistry, Curitiba, Brazil. ‡Director, Department of Oral Implantology and Periodontics, Master's Program in Implantology, São Leopoldo Mandic School of Dentistry, Curitiba, Brazil.
André
A
Zétola
Marisa
M
do Valle
Sahara
S
Littieri
Dieter
D
Baumgart
Ricardo
R
Gapski
D000539:Alveolar Process / Q000000981:diagnostic imaging / Q000187:drug effects; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011861:Radiography, Dental; D014057:Tomography, X-Ray Computed
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate