Mussel-inspired nanofibrous sheet for suture-less stomach incision surgery.
We report a dopamine-based crosslinker-conjugated gelatin/polycaprolactone nanofibrous sheet. The nanosheet was then employed to treat stomach incisions without sutures during surgery. The mussel-inspired nanosheets, combining the advantages adhesion and tissue repair, show promise for use in treatments of fragile tissues and to avoid suture-caused stress concentration.
Department of Mechanical Engineering, University of Manitoba, Winnipeg MB, R3T 2N2, Canada. Malcolm.xing@umanitoba.ca.
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D000818:Animals; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000494:pharmacology*; D004298:Dopamine / Q000737:chemistry; D005780:Gelatin / Q000737:chemistry; D051379:Mice; D015394:Molecular Structure; D057139:Nanofibers / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D013270:Stomach / Q000187:drug effects* / Q000601:surgery*; D013537:Sutures; D014945:Wound Healing / Q000187:drug effects
D003432:Cross-Linking Reagents; D011091:Polyesters; C016240:polycaprolactone; D005780:Gelatin; D004298:Dopamine