Nedaplatin salvage chemotherapy for cervical cancer.
OBJECTIVE
This systematic analysis was conducted to evaluate the efficacy and safety of nedaplatin based salvage chemotherapy for treatment of patients with advanced cervical cancer.


METHODS
Clinical studies evaluating the efficacy and safety of nedaplatin based regimens on response and safety for patients with cervical cancer were identified using a predefined search strategy. Pooled response rates (RRs) were calculated.


RESULTS
For nedaplatin based regimens, 5 clinical studies including 264 patients with advanced cervical cancer were considered eligible for inclusion. The analysis showed that, in all patients, pooled RR was 74.6% (197/264). Major adverse effects were leukopenia, thrombocytopenia and nausea/vomiting. No treatment related death occurred with nedaplatin based treatment.


CONCLUSIONS
This systematic analysis suggests that nedaplatin based regimens are associated with good activity with acceptable tolerability in treating patients with advanced cervical cancer.
Department of Obstetrics and Gynecology, Ankang Hospital of Traditional Chinese Medicine, Shanxi, China E-mail : wuju0998@163.com.
Wu-Ju
WJ
Li
Jia-Ying
JY
Jiang
Xian-Lian
XL
Wang
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D015201:Meta-Analysis as Topic; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D011379:Prognosis; D016879:Salvage Therapy; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C053989:nedaplatin