Matrix metalloproteinase 2 (MMP2) protein expression and laryngeal cancer prognosis: a meta analysis.
OBJECTIVE
To investigate the protein expression of matrix metalloproteinase 2 (MMP2) and its clinical significance in laryngeal cancer.


METHODS
A comprehensive search for the related literature published in China and other countries was conducted in a variety of databases, including MEDLINE, Embase, China Academic Journals Full-text Database, Wanfang Data and VIP Database. A total of seven case-control studies were included in the final systematic assessment. A meta-analysis software program was used to statistically analyze the raw data from each study for the calculation of the pooled odds ratio (OR) and 95% confidence interval (95% CI).


RESULTS
The meta-analysis indicated that, compared with normal laryngeal tissue, the MMP2 protein was highly expressed in the laryngeal cancer tissue [OR=21.67; 95% CI: 11.61-40.43; P<0.001]. Compared with highly differentiated laryngeal cancer, the MMP2 protein expression level was higher in the moderately and poorly differentiated laryngeal cancers [OR=0.25; 95% CI: 0.13-0.46; P<0.001]. Compared with laryngeal cancers without lymph node metastasis, the laryngeal cancers with lymph node metastasis exhibited a greatly elevated MMP2 protein expression [OR=0.25; 95% CI: 0.14-0.46; P<0.001].


CONCLUSIONS
High protein expression levels of MMP2 may play an important role in the tumorigenesis, progression and prognosis of laryngeal cancer.
Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
Rong-Rong
RR
Liu
Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
Ming-Dong
MD
Li
Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
Te
T
Li
Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
Yun
Y
Tan
Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
Min
M
Zhang
Department of Otolaryngology Head and Neck Surgery, Institute of Surgery Research & Daping Hospital, Third Military Medical University Chongqing 400042, China.
Ji-Chuan
JC
Chen
Laryngeal cancer; matrix metalloproteinase 2 (MMP2); meta-analysis