Clinical characteristics of hepatitis B and C virus infections in HIV-infected patients.
BACKGROUND
Hepatitis B virus (HBV) and hepatitis C virus (HCV) share a common route of transmission with human immunodeficiency virus (HIV). HIV co-infected with HBV or HCV was associated with a progression to severe liver disease, increased risk of hepatotoxicity from antiretroviral therapy and reduced survival. Data regarding HBV and HCV infection in HIV-positive individuals in Thailand is limited.


OBJECTIVE
To investigate the prevalence and clinical characteristics of HBV and HCV infection in HIV-infected patients in Siriraj Hospital.


METHODS
A retrospective study was conducted in adult HIV-positive followed up at the Infectious Disease Clinic, Siriraj Hospital. Prevalence of HBV and HCV infections and clinical characteristics were analyzed.


RESULTS
250 HIV-positive patients were enrolled, mean age was 38.8 years and 57.2% were male. HBV infection was found in 6.5% (15/231), and HCV infection was 7.7% (17/222). One patient had both HBV and HCV infections. In multivariate analysis, factors associated with either HBV or HCV co-infection included male gender (77.4% vs. 55%; p 0.008), history of salmonellosis (9.7% vs. 2.5%; p 0.042) or elevated serum alanine aminotransferase (ALT) level (34 U/L vs. 25 U/L; p 0.018). Factors associated with HBV infection, compared with those without hepatitis virus infection, included male gender (86.7% vs. 56%; p 0.038), history of salmonellosis (20% vs. 2.3%; p 0.005), elevated serum ALT level (42 U/L vs. 25 U/L; p 0.012) and low CD4 percent (1.05% vs. 5.02%; p 0.04). In this study, we did not find any factor associated with HCV infection in HIV patients.


CONCLUSIONS
The prevalence of HBV and HCV infection in HIV-infected Thai patients is significant. Male gender, history of salmonellosis, elevated serum ALT levels, and low CD4 percent are associated with HBV co-infection.
Prapinpa
P
Phuangchoei
Watcharasak
W
Chotiyaputta
Methee
M
Chayakulkeeree
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D060085:Coinfection / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013785:Thailand / Q000453:epidemiology
D000410:Alanine Transaminase