Translational research will fail without surgical leadership: SCOTRRCC a successful surgeon-led Nationwide translational research infrastructure in renal cancer.
BACKGROUND
High quality human biosamples with associated high quality clinical data are essential for successful translational research. Despite this, the traditional approach is for the surgeon to act as a technician in the tissue collection act. Biomarker research presents multiple challenges and the field is littered with failures. Tissue quality, poor clinical information, small sample numbers and lack of validation cohorts are just a few reasons for failure. It is clear that the surgeon involved in tissue acquisition must be fully engaged in the process of biosampling for a specific condition, as this will negate many of the issues for translational research failure due to an inadequate bioresource.


METHODS
In this Matter for Debate paper, the Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC) is discussed as an example of a urological surgery lead bioresource which has resulted in a National collection of renal cancer tissue and blood (from over 900 patients to date), negating all of the traditional issues with biobanks because of close enagagement and acknowledgement of urologists and uropathologists from seven centres around Scotland. SCOTRRCC has leveraged renal cancer research in Scotland resulting in several high impact publications and providing a springboard for future research in this disease in Scotland and beyond.


CONCLUSIONS
The SCOTRRCC model presented here can be transferred to other surgical disciplines for success in translational research.
Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK. Electronic address: grant.stewart@ed.ac.uk.
Grant D
GD
Stewart
Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK.
Antony C P
AC
Riddick
NHS Lothian, UK.
Frances
F
Rae
NHS Lothian, UK.
Craig
C
Marshall
NHS Lothian, UK.
Linda
L
MacLeod
Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK.
Fiach C
FC
O'Mahony
Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK.
Alexander
A
Laird
Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK.
S
S
Alan McNeill
Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK.
Kevin M
KM
O'Connor
Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK.
Marie
M
O'Donnell
NHS Lothian, UK.
Paul
P
Fineron
NHS Lothian, UK.
Duncan B
DB
McLaren
NHS Greater Glasgow and Clyde, UK.
Michael
M
Aitchison
NHS Greater Glasgow and Clyde, UK.
Grenville
G
Oades
NHS Greater Glasgow and Clyde, UK.
Jane
J
Hair
NHS Greater Glasgow and Clyde, UK.
Morag
M
Seywright
NHS Ayrshire and Arran, UK.
Brian
B
Little
NHS Ayrshire and Arran, UK.
Robert
R
Nairn
NHS Forth Valley, UK.
Gavin
G
Lamb
NHS Forth Valley, UK.
Torquil
T
Macleod
NHS Lanarkshire, UK.
Ian
I
Dunn
NHS Lanarkshire, UK.
Alison
A
Ramsey
NHS Lanarkshire, UK.
Roderick
R
Campbell
NHS Fife, UK.
Steve
S
Leung
NHS Fife, UK.
Liza
L
McLornan
NHS Fife, UK.
Maeve
M
Rahilly
NHS Highland, UK.
Ian
I
Wilson
NHS Highland, UK.
Anne-Marie
AM
Pollock
Edinburgh Urological Cancer Group, University of Edinburgh, Edinburgh, UK; NHS Lothian, UK; School of Medicine, St. Andrews University, St. Andrews, UK.
David J
DJ
Harrison
D014408:Biomarkers, Tumor; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000601:surgery; D002986:Clinical Trials as Topic; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000601:surgery; D007857:Leadership; D012606:Scotland; D013048:Specimen Handling / Q000592:standards*; D014015:Tissue Banks / Q000592:standards; D057170:Translational Research, Biomedical / Q000458:organization & administration / Q000592:standards*
D014408:Biomarkers, Tumor
Nationwide; Renal Cancer; Surgeon-led; Translational research