Protein S deficiency present in a pregnant woman with dyspnea, abdominal pains, restlessness, agitation and hypofibrinogenemia.
Hypofibrinogenemia is rare in pulmonary thromboembolism. A pregnant woman with dyspnea, abdominal pain, restlessness, agitation and protein S deficiency exhibited normal blood oxygenation and high D-dimer (370 μg/mL) and undetectable fibrinogen levels in the blood. The pathogenesis responsible for present findings may have some features similar to amniotic fluid embolism.
Department of Obstetrics, Hokkaido University Graduate School of Medicine Sapporo, 060-8638, Japan.
Takeshi
T
Umazume
Department of Obstetrics, Hokkaido University Graduate School of Medicine Sapporo, 060-8638, Japan.
Mamoru
M
Morikawa
Department of Obstetrics, Hokkaido University Graduate School of Medicine Sapporo, 060-8638, Japan.
Takahiro
T
Yamada
Department of Obstetrics, Hokkaido University Graduate School of Medicine Sapporo, 060-8638, Japan.
Rina
R
Akaishi
Department of Obstetrics, Hokkaido University Graduate School of Medicine Sapporo, 060-8638, Japan.
Takahiro
T
Koyama
Department of Obstetrics, Hokkaido University Graduate School of Medicine Sapporo, 060-8638, Japan.
Hisanori
H
Minakami
Amniotic fluid embolism; coagulopathy; maternal complication; protein S deficiency; pulmonary thromboembolism; twin pregnancy