No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370.



Centralized genotyping and analysis were performed for 140,012 women enrolled in the Ovarian Cancer Association Consortium (15,357 ovarian cancer patients; 30,816 controls), the Breast Cancer Association Consortium (33,530 breast cancer patients; 37,640 controls), and the Consortium of Modifiers of BRCA1 and BRCA2 (14,765 BRCA1 and 7904 BRCA2 mutation carriers).



We found no association with risk of ovarian cancer (OR=0.99, 95% CI 0.94-1.04, p=0.74) or breast cancer (OR=0.98, 95% CI 0.94-1.01, p=0.19) and results were consistent among mutation carriers (BRCA1, ovarian cancer HR=1.09, 95% CI 0.97-1.23, p=0.14, breast cancer HR=1.04, 95% CI 0.97-1.12, p=0.27; BRCA2, ovarian cancer HR=0.89, 95% CI 0.71-1.13, p=0.34, breast cancer HR=1.06, 95% CI 0.94-1.19, p=0.35). Null results were also obtained for associations with overall survival following ovarian cancer (HR=0.94, 95% CI 0.83-1.07, p=0.38), breast cancer (HR=0.96, 95% CI 0.87-1.06, p=0.38), and all other previously-reported associations.



rs61764370 is not associated with risk of ovarian or breast cancer nor with clinical outcome for patients with these cancers. Therefore, genotyping this variant has no clinical utility related to the prediction or management of these cancers.
Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Antoinette
A
Hollestelle
Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Frederieke H
FH
van der Baan
Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA. Electronic address: berch001@mc.duke.edu.
Andrew
A
Berchuck
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Sharon E
SE
Johnatty
Comprehensive Cancer Center The Netherlands, Utrecht, The Netherlands; Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands.
Katja K
KK
Aben
Landspitali University Hospital, Reykjavik, Iceland; University of Iceland, School of Medicine, Reykjavik, Iceland.
Bjarni A
BA
Agnarsson
Department of Clinical Genetics, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Kristiina
K
Aittomäki
Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Elisa
E
Alducci
Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Irene L
IL
Andrulis
Department of Epidemiology, University of California Irvine, Irvine, CA, USA.
Hoda
H
Anton-Culver
N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
Natalia N
NN
Antonenkova
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Antonis C
AC
Antoniou
Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
Carmel
C
Apicella
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
Volker
V
Arndt
Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein, University Kiel, Kiel, Germany.
Norbert
N
Arnold
Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Banu K
BK
Arun
Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
Brita
B
Arver
Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
Alan
A
Ashworth
Cancer Division, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia; Peter MacCallum Cancer Institute, Melbourne, VIC, Australia; Center for Cancer Research, University of Sydney at Westmead Millennium Institute, Sydney, Australia.
Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Laura
L
Baglietto
Western Sydney and Nepean Blue Mountains Local Health Districts, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.
Rosemary
R
Balleine
Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Elisa V
EV
Bandera
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Daniel
D
Barrowdale
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
Yukie T
YT
Bean
Institute for Quality and Efficiency in Health Care (IQWiG), Cologne, Germany.
Lars
L
Beckmann
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany.
Matthias W
MW
Beckmann
Centro Nacional de Genotipación, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain; University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
Javier
J
Benitez
Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Andreas
A
Berger
Sheba Medical Center, Tel Aviv, Israel.
Raanan
R
Berger
Multidisciplinary Breast Center, University Hospital Leuven, University of Leuven, Belgium.
Benoit
B
Beuselinck
Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Maria
M
Bisogna
Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.
Line
L
Bjorge
Department of Oncology, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland.
Carl
C
Blomqvist
Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany; Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
Natalia V
NV
Bogdanova
Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
Anders
A
Bojesen
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Stig E
SE
Bojesen
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Manjeet K
MK
Bolla
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
Bernardo
B
Bonanni
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Judith S
JS
Brand
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; Cancer Research Center (DKFZ), Heidelberg, Germany.
Hiltrud
H
Brauch
Department of Epidemiology, Cancer Prevention Institute of California, Fremont, CA, USA.
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
Hermann
H
Brenner
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Louise
L
Brinton
Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Angela
A
Brooks-Wilson
Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Fiona
F
Bruinsma
Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI-Catalan Institute of Oncology, Girona, Spain.
Joan
J
Brunet
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany.
Thomas
T
Brüning
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Agnieszka
A
Budzilowska
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Clareann H
CH
Bunker
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Barbara
B
Burwinkel
Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland; Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Ralf
R
Butzow
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA.
Saundra S
SS
Buys
Section of Genetic Oncology, Department of Laboratory Medicine, University Hospital of Pisa, University of Pisa, Pisa, Italy.
Maria A
MA
Caligo
Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Australia; Department of Pathology, University of Melbourne, Melbourne, VIC, Australia.
Ian
I
Campbell
Gynaecological Oncology, The Chris O'Brien Lifehouse and The University of Sydney, Sydney, Australia.
Jonathan
J
Carter
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jenny
J
Chang-Claude
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Stephen J
SJ
Chanock
Center for Medical Genetics, Ghent University, Ghent, Belgium.
Kathleen B M
KBM
Claes
Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
J Margriet
JM
Collée
Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque, NM, USA.
Linda S
LS
Cook
Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA; Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.
Fergus J
FJ
Couch
Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK.
Angela
A
Cox
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Daniel
D
Cramer
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.
Simon S
SS
Cross
Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA.
Julie M
JM
Cunningham
International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical Academy, Szczecin, Poland.
Cezary
C
Cybulski
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kamila
K
Czene
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Francesca
F
Damiola
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Agnieszka
A
Dansonka-Mieszkowska
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hatef
H
Darabi
Molecular Oncology Laboratory, Hospital Clinico San Carlos, Madrid, Spain.
Miguel
M
de la Hoya
Center for Cancer Research, University of Sydney at Westmead Millennium Institute, Sydney, Australia; Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia.
Anna
A
deFazio
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Joseph
J
Dennis
Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Peter
P
Devilee
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Ed M
EM
Dicks
Oncogenetics Laboratory, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Orland
O
Diez
Section of Biostatistics and Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Jennifer A
JA
Doherty
Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Basser Research Centre, Abramson Cancer Center, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Susan M
SM
Domchek
Department of Genetics, University of Pretoria, Pretoria, South Africa.
Cecilia M
CM
Dorfling
Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Thilo
T
Dörk
Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Isabel Dos Santos
IDS
Silva
Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, Wiesbaden, Germany; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.
Andreas
A
du Bois
Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec, Canada.
Martine
M
Dumont
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Alison M
AM
Dunning
Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain.
Mercedes
M
Duran
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Douglas F
DF
Easton
Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, UK.
Diana
D
Eccles
Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Robert P
RP
Edwards
Department of Clinical Genetics, Lund University, Lund, Sweden.
Hans
H
Ehrencrona
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Bent
B
Ejlertsen
Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Arif B
AB
Ekici
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Steve D
SD
Ellis
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Christoph
C
Engel
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mikael
M
Eriksson
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany; David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, CA, USA.
Peter A
PA
Fasching
Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
Lidia
L
Feliubadalo
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jonine
J
Figueroa
Department of Cancer Epidemiology/Clinical Cancer Registry, Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Dieter
D
Flesch-Janys
Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
Olivia
O
Fletcher
Clinical Cancer Genetics, City of Hope, Duarte, CA, USA; New Mexico Cancer Center, Albuquerque, NM, USA.
Annette
A
Fontaine
Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Milan, Italy; Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
Stefano
S
Fortuzzi
Molecular Diagnostics Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece.
Florentia
F
Fostira
Kansas IDeA Network of Biomedical Research Excellence Bioinformatics Core, The University of Kansas Cancer Center, Kansas City, KS, USA.
Brooke L
BL
Fridley
University of Pennsylvania, Philadelphia, PA, USA.
Tara
T
Friebel
The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel; Institute of Oncology, Sheba Medical Center, Tel-Hashomer, Israel.
Eitan
E
Friedman
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Grace
G
Friel
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Debra
D
Frost
Center for Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, MA, USA.
Judy
J
Garber
Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
Montserrat
M
García-Closas
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Simon A
SA
Gayther
GEMO Study: National Cancer Genetics Network, UNICANCER Genetic Group, France.
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany; Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany; Institute of Pathology, Medical Faculty of the University of Bonn, Bonn, Germany; Institute of Occupational Medicine and Maritime Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Cancer Research Center (DKFZ), Heidelberg, Germany.
Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, UCL, London, UK.
Aleksandra
A
Gentry-Maharaj
Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Anne-Marie
AM
Gerdes
Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Graham G
GG
Giles
Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, UK.
Rosalind
R
Glasspool
Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Gord
G
Glendon
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Andrew K
AK
Godwin
Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Marc T
MT
Goodman
Gynecological Oncology Unit, The Royal Marsden Hospital, London, UK.
Martin
M
Gore
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Mark H
MH
Greene
Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
Mervi
M
Grip
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jacek
J
Gronwald
Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Daphne
D
Gschwantler Kaulich
INSERM U1018, CESP (Center for Research in Epidemiology and Population Health), Environmental Epidemiology of Cancer, Villejuif, France; University Paris-Sud, UMRS 1018, Villejuif, France.
Pascal
P
Guénel
Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Starr R
SR
Guzman
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany.
Lothar
L
Haeberle
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Christopher A
CA
Haiman
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Per
P
Hall
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Sandra L
SL
Halverson
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ute
U
Hamann
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Thomas V O
TVO
Hansen
Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, Wiesbaden, Germany; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.
Philipp
P
Harter
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Jaana M
JM
Hartikainen
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Sue
S
Healey
The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Coordinating Center: Netherlands Cancer Institute, Amsterdam, The Netherlands.
University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center, Erlangen, Germany.
Alexander
A
Hein
Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, Wiesbaden, Germany; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.
Florian
F
Heitz
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Brian E
BE
Henderson
Clinical Cancer Genetics, City of Hope, Duarte, CA, USA.
Josef
J
Herzog
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michelle A
MA
T Hildebrandt
Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Claus K
CK
Høgdall
Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark; Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Estrid
E
Høgdall
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Frans B L
FBL
Hogervorst
Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
John L
JL
Hopper
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Keith
K
Humphreys
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Tomasz
T
Huzarski
N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
Evgeny N
EN
Imyanitov
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Claudine
C
Isaacs
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Anna
A
Jakubowska
Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, State Research Centre Institute for Innovative Medicine, Vilnius, Lithuania.
Ramunas
R
Janavicius
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland; Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland.
Katarzyna
K
Jaworska
Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Allan
A
Jensen
Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
Uffe Birk
UB
Jensen
Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
Nichola
N
Johnson
Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.
Arja
A
Jukkola-Vuorinen
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Maria
M
Kabisch
Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Beth Y
BY
Karlan
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland; Jyväskylä Central Hospital, Jyväskylä, Finland.
Vesa
V
Kataja
Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Noah
N
Kauff
kConFab: Kathleen Cuningham Consortium for Research into Familial Breast Cancer - Peter MacCallum Cancer Center, Melbourne, Australia.
Department of Population Health Research, Alberta Health Services-Cancer Care, Calgary, Alberta, Canada; Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada; Department of Oncology, University of Calgary, Calgary, Alberta, Canada.
Linda E
LE
Kelemen
School of Medicine, National University of Ireland, Galway, Ireland.
Michael J
MJ
Kerin
Department for Health Evidence, Radboud University Medical Centre, Nijmegen, The Netherlands; Department of Urology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Lambertus A
LA
Kiemeney
Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Susanne K
SK
Kjaer
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada; Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Julia A
JA
Knight
Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Jacoba P
JP
Knol-Bout
Molecular Diagnostics Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece.
Irene
I
Konstantopoulou
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Veli-Matti
VM
Kosma
Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.
Camilla
C
Krakstad
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway; Faculty of Medicine (Faculty Division Ahus), Universitetet i Oslo, Norway.
Vessela
V
Kristensen
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Karoline B
KB
Kuchenbaecker
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Jolanta
J
Kupryjanczyk
The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel; Institute of Oncology, Sheba Medical Center, Tel-Hashomer, Israel.
Yael
Y
Laitman
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium; Vesalius Research Center (VRC), VIB, Leuven, Belgium.
Diether
D
Lambrechts
Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium; Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Sandrina
S
Lambrechts
Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Melissa C
MC
Larson
Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Adriana
A
Lasa
Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France.
Pierre
P
Laurent-Puig
Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
Conxi
C
Lazaro
Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
Nhu D
ND
Le
Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Loic
L
Le Marchand
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Arto
A
Leminen
Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jenny
J
Lester
Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Douglas A
DA
Levine
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Jingmei
J
Li
College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA.
Dong
D
Liang
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Annika
A
Lindblom
Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Noralane
N
Lindor
Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland.
Jolanta
J
Lissowska
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Jirong
J
Long
Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Karen H
KH
Lu
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan
J
Lubinski
Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Lene
L
Lundvall
Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Galina
G
Lurie
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Phuong L
PL
Mai
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland; School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Arto
A
Mannermaa
Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Sara
S
Margolin
Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Milan, Italy; Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
Frederique
F
Mariette
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
Frederik
F
Marme
Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
John W M
JWM
Martens
Department of Gynecology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Leon F A G
LFAG
Massuger
Laboratoire de Diagnostic Génétique et Service d'Onco-hématologie, Hopitaux Universitaire de Strasbourg, CHRU Nouvel Hôpital Civil, Strasbourg, France.
Christine
C
Maugard
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Sylvie
S
Mazoyer
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Lesley
L
McGuffog
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.
Valerie
V
McGuire
Anatomical Pathology, The Alfred Hospital, Melbourne, Australia.
Catriona
C
McLean
Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK.
Iain
I
McNeish
Department of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Alfons
A
Meindl
INSERM U1018, CESP (Center for Research in Epidemiology and Population Health), Environmental Epidemiology of Cancer, Villejuif, France; University Paris-Sud, UMRS 1018, Villejuif, France.
Florence
F
Menegaux
Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain.
Primitiva
P
Menéndez
Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.
Janusz
J
Menkiszak
Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, UCL, London, UK.
Usha
U
Menon
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Arjen R
AR
Mensenkamp
School of Medicine, National University of Ireland, Galway, Ireland.
Nicola
N
Miller
Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia.
Roger L
RL
Milne
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
Francesmary
F
Modugno
Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Marco
M
Montagna
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Kirsten B
KB
Moysich
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
Heiko
H
Müller
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Laboratory Medicine Program, University Health Network, Toronto, ON, Canada.
Anna Marie
AM
Mulligan
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Taru A
TA
Muranen
Women's College Research Institute, University of Toronto, Toronto, ON, Canada.
Steven A
SA
Narod
Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Basser Research Centre, Abramson Cancer Center, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.
Katherine L
KL
Nathanson
The University of Texas School of Public Health, Houston, TX, USA.
Roberta B
RB
Ness
Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA.
Susan L
SL
Neuhausen
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Heli
H
Nevanlinna
Multidisciplinary Breast Center, University Hospital Leuven, University of Leuven, Belgium.
Patrick
P
Neven
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Finn C
FC
Nielsen
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Sune F
SF
Nielsen
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Børge G
BG
Nordestgaard
Department of Medicine and Institute for Human Genetics, University of California, San Francisco, CA, USA.
Robert L
RL
Nussbaum
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Kunle
K
Odunsi
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Kenneth
K
Offit
Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
Edith
E
Olah
Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, IL, USA.
Olufunmilayo I
OI
Olopade
Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Janet E
JE
Olson
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Sara H
SH
Olson
University of Groningen, University Medical Center, Department of Genetics, Groningen, The Netherlands.
Jan C
JC
Oosterwijk
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Irene
I
Orlow
Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
Nick
N
Orr
Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Sandra
S
Orsulic
Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain; Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain; Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Ana
A
Osorio
Department of Molecular Medicine, Sapienza University, Rome, Italy.
Laura
L
Ottini
Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, UK.
James
J
Paul
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Celeste L
CL
Pearce
Section of Molecular Diagnostics, Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
Inge Sokilde
IS
Pedersen
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori (INT), Milan, Italy.
Bernard
B
Peissel
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA; Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
Tanja
T
Pejovic
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
Liisa M
LM
Pelttari
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Jo
J
Perkins
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Jenny
J
Permuth-Wey
Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Milan, Italy.
Paolo
P
Peterlongo
Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Julian
J
Peto
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Catherine M
CM
Phelan
Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Australia; Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia; Department of Medicine, St Vincent's Hospital, The University of Melbourne, Victoria, Australia.
Kelly-Anne
KA
Phillips
NRG Oncology Statistics and Data Management Center, Buffalo, NY, USA.
Marion
M
Piedmonte
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Malcolm C
MC
Pike
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Radka
R
Platte
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Joanna
J
Plisiecka-Halasa
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Elizabeth M
EM
Poole
Center for Medical Genetics, Ghent University, Ghent, Belgium.
Bruce
B
Poppe
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics, University of Oulu, Oulu University Hospital, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland.
Katri
K
Pylkäs
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori (INT), Milan, Italy.
Paolo
P
Radice
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Susan J
SJ
Ramus
Basser Research Centre, Abramson Cancer Center, The University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA; Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Timothy R
TR
Rebbeck
Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK.
Malcolm W R
MWR
Reed
Clalit National Israeli Cancer Control Center, Haifa, Israel; Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel.
Gad
G
Rennert
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Harvey A
HA
Risch
Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Mark
M
Robson
NorthShore University Health System, University of Chicago, Evanston, IL, USA.
Gustavo C
GC
Rodriguez
Molecular Oncology Laboratory, Hospital Clinico San Carlos, Madrid, Spain.
Atocha
A
Romero
Department of Epidemiology, University of Washington, Seattle, WA, USA; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Mary Anne
MA
Rossing
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.
Joseph H
JH
Rothstein
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Anja
A
Rudolph
Department of Gynecology, Jena University Hospital, Jena, Germany.
Ingo
I
Runnebaum
Ohio State University, Columbus, OH, USA.
Ritu
R
Salani
Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.
Helga B
HB
Salvesen
Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London, London, UK.
Elinor J
EJ
Sawyer
Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA; Cancer Prevention, Detection and Control Research Program, Duke Cancer Institute, Durham, NC, USA.
Joellen M
JM
Schildkraut
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Marjanka K
MK
Schmidt
Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany; Centre for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany.
Rita K
RK
Schmutzler
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
Andreas
A
Schneeweiss
Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK.
Minouk J
MJ
Schoemaker
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany.
Michael G
MG
Schrauder
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Fredrick
F
Schumacher
Institut für Humangenetik Wiesbaden, Wiesbaden, Germany.
Ira
I
Schwaab
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori (INT), Milan, Italy.
Giulietta
G
Scuvera
Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Thomas A
TA
Sellers
Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Gianluca
G
Severi
Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Caroline M
CM
Seynaeve
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Mitul
M
Shah
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Martha
M
Shrubsole
Department of Gynecological Oncology, Glasgow Royal Infirmary, Glasgow, UK.
Nadeem
N
Siddiqui
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.
Weiva
W
Sieh
Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec, Canada.
Jacques
J
Simard
Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Christian F
CF
Singer
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France; Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Léon Bérard, Lyon, France.
Olga M
OM
Sinilnikova
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium; Vesalius Research Center (VRC), VIB, Leuven, Belgium.
Dominiek
D
Smeets
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Christof
C
Sohn
Department of Clinical Genetics, University and Regional Laboratories, Lund University Hospital, Lund, Sweden.
Maria
M
Soller
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Honglin
H
Song
Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec, Canada.
Penny
P
Soucy
Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
Melissa C
MC
Southey
Saarland Cancer Registry, Saarbrücken, Germany.
Christa
C
Stegmaier
Institut Curie, Department of Tumour Biology, Paris, France; Institut Curie, INSERM U830, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, France.
Dominique
D
Stoppa-Lyonnet
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Lara
L
Sucheston
Department of Oncology, Lund University, Lund, Sweden.
Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK; Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, Surrey, UK.
Anthony
A
Swerdlow
Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.
Ingvild L
IL
Tangen
Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Muy-Kheng
MK
Tea
Department of Genetics, Portuguese Oncology Institute, Porto, Portugal; Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal.
Manuel R
MR
Teixeira
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Kathryn L
KL
Terry
Department of Epidemiology, Columbia University, New York, NY, USA.
Mary Beth
MB
Terry
Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Mads
M
Thomassen
Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Pamela J
PJ
Thompson
Latvian Biomedical Research and Study Centre, Riga, Latvia.
Laima
L
Tihomirova
Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.
Marc
M
Tischkowitz
Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Amanda Ewart
AE
Toland
Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Rob A E M
RAEM
Tollenaar
Welcome Trust Centre for Human Genetics, University of Oxford, UK; Oxford Biomedical Research Centre, University of Oxford, UK.
Ian
I
Tomlinson
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia.
Diana
D
Torres
INSERM U1018, CESP (Center for Research in Epidemiology and Population Health), Environmental Epidemiology of Cancer, Villejuif, France; University Paris-Sud, UMRS 1018, Villejuif, France.
Thérèse
T
Truong
Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
Helen
H
Tsimiklis
Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Nadine
N
Tung
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Shelley S
SS
Tworoger
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Jonathan P
JP
Tyrer
Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Celine M
CM
Vachon
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Laura J
LJ
Van 't Veer
Department of Gynecology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Anne M
AM
van Altena
Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
C J
CJ
Van Asperen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
David
D
van den Berg
Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Ans M W
AMW
van den Ouweland
Department of Gynecology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Helena C
HC
van Doorn
Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium; Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Els
E
Van Nieuwenhuysen
Department of Genetics, University of Pretoria, Pretoria, South Africa.
Elizabeth J
EJ
van Rensburg
Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium; Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Ignace
I
Vergote
Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Senno
S
Verhoef
Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Robert A
RA
Vierkant
Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Joseph
J
Vijai
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Allison F
AF
Vitonis
Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
Anna
A
von Wachenfeldt
Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Christine
C
Walsh
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Qin
Q
Wang
Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
Shan
S
Wang-Gohrke
Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany; Centre for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany.
Barbara
B
Wappenschmidt
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Maren
M
Weischer
Clinical Cancer Genetics, City of Hope, Duarte, CA, USA.
Jeffrey N
JN
Weitzel
Multidisciplinary Breast Center, University Hospital Leuven, University of Leuven, Belgium.
Caroline
C
Weltens
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Nicolas
N
Wentzensen
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.
Alice S
AS
Whittemore
Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Lynne R
LR
Wilkens
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics, University of Oulu, Oulu University Hospital, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland.
Robert
R
Winqvist
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Anna H
AH
Wu
Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xifeng
X
Wu
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Hannah P
HP
Yang
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori (INT), Milan, Italy.
Daniela
D
Zaffaroni
Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain.
M
M
Pilar Zamora
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Wei
W
Zheng
Department of Epidemiology, Center for Cancer Genetics Research and Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA.
Argyrios
A
Ziogas
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Georgia
G
Chenevix-Trench
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Paul D P
PDP
Pharoah
Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Matti A
MA
Rookus
Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Maartje J
MJ
Hooning
Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
Ellen L
EL
Goode
D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics*; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000201:enzymology* / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*
C117307:KRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
Breast cancer; Clinical outcome; Genetic association; KRAS variant; Ovarian cancer