Aspirin-exacerbated respiratory disease: characteristics and management strategies.
Aspirin-exacerbated respiratory disease is a clinical entity comprising chronic rhinosinusitis with nasal polyposis, asthma and intolerance to COX-1 inhibiting drugs. The pathogenesis is not completely understood at this point, but abnormal arachidonic acid metabolism is a key feature in this syndrome. The diagnosis is confirmed only by direct drug challenge. Aspirin desensitization followed by daily aspirin therapy is a useful treatment option in these patients. In this review article are discussed the important characteristics and treatment of aspirin-exacerbated respiratory disease.
Scripps Clinic, Division of Allergy, Asthma and Immunology, 3811 Valley Centre Drive, San Diego, CA 92130, USA.
Ronald A
RA
Simon
Kristen M
KM
Dazy
Jeremy D
JD
Waldram
D000818:Animals; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D055963:Asthma, Aspirin-Induced / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000628:therapy; D003888:Desensitization, Immunologic; D006801:Humans; D009298:Nasal Polyps / Q000139:chemically induced / Q000276:immunology / Q000473:pathology / Q000628:therapy; D012220:Rhinitis / Q000139:chemically induced / Q000276:immunology / Q000473:pathology / Q000628:therapy; D012852:Sinusitis / Q000139:chemically induced / Q000276:immunology / Q000473:pathology / Q000628:therapy
D001241:Aspirin
Samter’s triad; aspirin desensitization; aspirin sensitivity; aspirin-exacerbated respiratory disease; asthma; nasal polyposis; rhinosinusitis