The potential clinical impact of the tissue-based map of the human proteome.
Since the first draft of the human genome sequence was published, several attempts have been made to map the human proteome, the functional representation of the genome. One such initiative is the Human Protein Atlas project, which recently released a tissue-based map of the human proteome. The Human Protein Atlas is based on the combination of transcriptomics and antibody-based proteomics for mapping the human proteome down to the single cell level. The comprehensive publicly available database contains more than 13 million unique immunohistochemistry images and provides an excellent resource for exploration and investigation of future drug targets and disease biomarkers.
Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Cecilia
C
Lindskog
D000906:Antibodies / Q000378:metabolism; D015510:Clinical Medicine / Q000639:trends; D016045:Human Genome Project; D006801:Humans; D009928:Organ Specificity; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics; D059467:Transcriptome
D000906:Antibodies; D020543:Proteome
immunohistochemistry; proteome; proteomics; tissue microarrays; transcriptomics