Serum S100B level may be correlated with carbon monoxide poisoning.
OBJECTIVE
To investigate the correlation between serum S100B level and carbon monoxide (CO) poisoning by meta-analysis.


METHODS
By searching both English and Chinese language-based electronic databases (PubMed, EBSCO, Ovid, Springerlink, Wiley, Web of Science, Wanfang databases, China national knowledge infrastructure (CNKI), VIP database, etc.) thoroughly, we tabulated and analyzed the collected data with the use of Comprehensive Meta-analysis 2.0 (CMA 2.0).


RESULTS
Totally 108 studies have been searched initially (92 studies in Chinese, 16 studies in English). Nine case-control studies (4 studies in English, 5 in Chinese) were chosen for an updated meta-analysis including 542 patients with CO poising and 236 healthy controls. Results identified that the serum S100B level were obviously higher than that in healthy controls (SMD=1.600, 95% CI=1.055-2.145, P<0.001). A subgroup based on the ethnicities revealed that the serum S100B level in Caucasian and Asian subgroups was clearly higher than serum S100B level in healthy controls (Asians: SMD=2.0624, 95% CI=1.736-3.511, P<0.001; Caucasians: SMD=0.447, 95% CI=0.197-0.697, P<0.001).


CONCLUSIONS
Serum S100B level may be correlated with the CO poisoning and could be effective biomarker for early diagnosis and treatment monitoring in CO poisoning.
Department of Emergency, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, PR China.
Hui
H
Liu
Department of Emergency, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, PR China.
Yu
Y
Zhang
Department of Emergency, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, PR China.
Yan-Bo
YB
Ren
Department of Emergency, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, PR China.
Jian
J
Kang
Department of Emergency, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, PR China.
Jing
J
Xing
Department of Abdominal Emergency, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, PR China.
Qing-Hui
QH
Qi
Department of Emergency, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, PR China. Electronic address: gaodongna@163.com.
Dong-Na
DN
Gao
Department of Emergency, The First Affiliated Hospital of China Medical University, Shenyang 110001, PR China.
Tao
T
Ma
Department of Emergency, The First Affiliated Hospital of China Medical University, Shenyang 110001, PR China.
Xiao-Wei
XW
Liu
Department of Emergency, The First Affiliated Hospital of China Medical University, Shenyang 110001, PR China.
Zhi
Z
Liu
D044466:Asian People; D015415:Biomarkers / Q000097:blood*; D002249:Carbon Monoxide Poisoning / Q000175:diagnosis* / Q000453:epidemiology; D042241:Early Diagnosis; D006801:Humans; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D044465:White People
D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human
Biomarker; Carbon monoxide poisoning; Case–control study; Correlation; Diagnosis; Meta-analysis; S100B; Treatment