Interactions between obesity-related copy number variants and dietary behaviors in childhood obesity.
Copy number variants (CNVs) have been implicated as an important genetic marker of obesity, and gene-environment interaction has been found to modulate risk of obesity. To evaluate the associations between CNVs and childhood obesity, as well as the interactions between CNVs and dietary behaviors, we recruited 534 obese children and 508 controls from six cities in China and six candidate CNVs were screened through published genome-wide studies (GWAS) on childhood obesity. We found three loci (10q11.22, 4q25 and 11q11) to be significantly associated with obesity after false discovery rate (FDR) correction (all the p ≤ 0.05). Cumulative effect of the three positive loci was measured by the genetic risk score (GRS), showing a significant relationship with the risk of obesity (Ptrend < 0.001). The OR of obesity increased to 21.38 (95% CI = 21.19-21.55) among the 10q11.22 deletion carriers who had meat-based diets, indicating prominent multiplicative interaction (MI) between deletions of 10q11.22 and preference for a meat-based diet. Simultaneous deletions of 5q13.2 and duplications of 6q14.1 had significant MI with a preference for salty foods. Our results suggested that CNVs may contribute to the genetic susceptibility of childhood obesity, and the CNV-diet interactions modulate the risk of obesity.
Department of Pathology, Zhejiang University School of Medicine, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. dandanz@zju.edu.cn.|Key Laboratory of Disease Proteomics of Zhejiang Province, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. dandanz@zju.edu.cn.
Dandan
D
Zhang
Department of Pathology, Zhejiang University School of Medicine, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. lizhenli8888@sina.com.|Key Laboratory of Disease Proteomics of Zhejiang Province, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. lizhenli8888@sina.com.
Zhenli
Z
Li
Department of Pathology, Zhejiang University School of Medicine, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. brenda_1985@163.com.|Key Laboratory of Disease Proteomics of Zhejiang Province, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. brenda_1985@163.com.
Hao
H
Wang
Department of Nutrition, Zhejiang University School of Public Health, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. ymin36@zju.edu.cn.
Min
M
Yang
Department of Pediatrics, the First Affiliated Hospital of College of Medicine, Zhejiang University, 79 Qing-chun Road, Hangzhou 310003, Zhejiang, China. zdliangli@163.com.
Li
L
Liang
Department of Endocrinology, Children's Hospital of College of Medicine, Zhejiang University, 25 Guang-fu Road, Hangzhou 310003, Zhejiang, China. fjf68@yahoo.com.cn.
Junfen
J
Fu
Department of Pediatrics, the First Affiliated Hospital of College of Medicine, Zhejiang University, 79 Qing-chun Road, Hangzhou 310003, Zhejiang, China. hzwangcl@yahoo.com.cn.
Chunling
C
Wang
Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. lingjie_22@163.com.
Jie
J
Ling
Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. joiny19@163.com.
Yan
Y
Zhang
Department of Pathology, Zhejiang University School of Medicine, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. ssnn@zju.edu.cn.|Key Laboratory of Disease Proteomics of Zhejiang Province, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. ssnn@zju.edu.cn.
Shuai
S
Zhang
Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. jlt422519@live.cn.
Yuyang
Y
Xu
Department of Epidemiology & Biostatistics, Zhejiang University School of Public Health, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. zhuym@zju.edu.cn.
Yimin
Y
Zhu
Department of Pathology, Zhejiang University School of Medicine, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. lmp@zju.edu.cn.|Key Laboratory of Disease Proteomics of Zhejiang Province, 866 Yu-hang-tang Road, Hangzhou 310058, Zhejiang, China. lmp@zju.edu.cn.
Maode
M
Lai
D000293:Adolescent; D000818:Animals; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002681:China; D002872:Chromosome Deletion; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D056915:DNA Copy Number Variations; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008460:Meat; D063766:Pediatric Obesity / Q000235:genetics*; D012307:Risk Factors