Ciliary subcompartments: how are they established and what are their functions?
Cilia are conserved subcellular organelles with diverse sensory and developmental roles. Recently, they have emerged as crucial organelles whose dysfunction causes a wide spectrum of disorders called ciliopathies. Recent studies on the pathological mechanisms underlying ciliopathies showed that the ciliary compartment is further divided into subdomains with specific roles in the biogenesis, maintenance and function of cilia. Several conserved sets of molecules that play specific roles in each subcompartment have been discovered. Here we review recent progress on our understanding of ciliary subcompartments, especially focusing on the molecules required for their structure and/or function.
Department of Life Science, University of Seoul, Seoul 130-743, Korea.
Jeongmi
J
Lee
Department of Life Science, University of Seoul, Seoul 130-743, Korea.
Yun Doo
YD
Chung
D000818:Animals; D002451:Cell Compartmentation; D002923:Cilia / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D008954:Models, Biological