The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation.
In recent years, it has been an explosion of information regarding the role of various myeloid cells in liver pathology. Macrophages and dendritic cell (DC) play crucial roles in multiple chronic liver diseases such as fibrosis and non-alcoholic fatty liver disease (NAFLD). The complexity of myeloid cell populations and the missing exclusive marker combination make the interpretation of the data often extremely difficult. The current review aims to summarize the multiple roles of macrophages and DCs in chronic liver diseases, especially pointing out how these cells influence liver immune and parenchymal cells thereby altering liver function and pathology. Moreover, the review outlines the currently known marker combinations for the identification of these cell populations for the study of their role in liver immunology.
Department of Medicine II, Saarland University Medical Center , Homburg , Germany.
Christoph
C
Eckert
Department of Medicine II, Saarland University Medical Center , Homburg , Germany.
Niklas
N
Klein
Department of Medicine II, Saarland University Medical Center , Homburg , Germany.
Miroslaw
M
Kornek
Department of Medicine II, Saarland University Medical Center , Homburg , Germany.
Veronika
V
Lukacs-Kornek
Kupffer cells; NASH; dendritic cells; inflammatory monocytes; liver fibrosis