Resting-state glutamatergic neurotransmission is related to the peak latency of the auditory mismatch negativity (MMN) for duration deviants: An (1)H-MRS-EEG study.
Mismatch negativity (MMN), an ERP elicited by a deviant stimulus in a train of standard stimuli, has been suggested to be associated to glutamatergic neurotransmission, mediated by glutamatergic NMDA receptors. In this study, we examined the relationship between interindividual variation of (1)H-MRS-measured glutamate+glutamine (Glx) in the superior temporal gyrus and MMN for duration and frequency deviants in 19 healthy young adults (9 male). We found a significant relationship between the peak latency of the duration-MMN peak and creatine-scaled Glx (p = .0003, η(2)  = .43), with increased Glx level being associated to earlier peak of the duration-MMN (r = -.63). In contrast, the amplitude of the duration-MMN was not related to Glx. There was no significant relationship between Glx and the frequency-MMN. The present study is the first to demonstrate that interindividual variation in the glutamatergic neurotransmission affects the MMN response in healthy individuals.
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.|NORMENT Center of Excellence, University of Oslo, Oslo, Norway.
Kristiina
K
Kompus
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.|Department of Psychology, University of Oslo, Oslo, Norway.
René
R
Westerhausen
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.|NORMENT Center of Excellence, University of Oslo, Oslo, Norway.
Alex R
AR
Craven
Institute of Psychology, University of Tartu, Tartu, Estonia.
Kairi
K
Kreegipuu
Institute of Psychology, University of Tartu, Tartu, Estonia.|Doctoral School of Behavioural, Social and Health Sciences, University of Tartu, Tartu, Estonia.
Nele
N
Põldver
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.|NORMENT Center of Excellence, University of Oslo, Oslo, Norway.
Susanne
S
Passow
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.|Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway.
Karsten
K
Specht
Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway.|NORMENT Center of Excellence, University of Oslo, Oslo, Norway.|Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.|Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Kenneth
K
Hugdahl
Institute of Psychology, University of Tartu, Tartu, Estonia.|Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.|Center of Functionally Integrated Neurosciences (CFIN), University of Aarhus, Aarhus, Denmark.
Risto
R
Näätänen
D000161:Acoustic Stimulation; D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D003265:Contingent Negative Variation / Q000502:physiology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009435:Synaptic Transmission / Q000502:physiology*; D013702:Temporal Lobe / Q000378:metabolism / Q000502:physiology*; D055815:Young Adult
D005973:Glutamine; D018698:Glutamic Acid
EEG; Learning; Normal volunteers; fMRI/PET/MRI