CHOgenome.org 2.0: Genome resources and website updates.
Chinese hamster ovary (CHO) cells are a major host cell line for the production of therapeutic proteins, and CHO cell and Chinese hamster (CH) genomes have recently been sequenced using next-generation sequencing methods. CHOgenome.org was launched in 2011 (version 1.0) to serve as a database repository and to provide bioinformatics tools for the CHO community. CHOgenome.org (version 1.0) maintained GenBank CHO-K1 genome data, identified CHO-omics literature, and provided a CHO-specific BLAST service. Recent major updates to CHOgenome.org (version 2.0) include new sequence and annotation databases for both CHO and CH genomes, a more user-friendly website, and new research tools, including a proteome browser and a genome viewer. CHO cell-line specific sequences and annotations facilitate cell line development opportunities, several of which are discussed. Moving forward, CHOgenome.org will host the increasing amount of CHO-omics data and continue to make useful bioinformatics tools available to the CHO community.
Chemical & Biomolecular Engineering, University of Delaware, Newark, DE, US.|Delaware Biotechnology Institute, Newark, DE, US.
Benjamin G
BG
Kremkow
Chemical & Biomolecular Engineering, University of Delaware, Newark, DE, US.|Delaware Biotechnology Institute, Newark, DE, US.
Jong Youn
JY
Baik
Delaware Biotechnology Institute, Newark, DE, US.|Computer & Information Sciences, University of Delaware, Newark, DE, US.
Madolyn L
ML
MacDonald
Chemical & Biomolecular Engineering, University of Delaware, Newark, DE, US. KHL@udel.edu.|Delaware Biotechnology Institute, Newark, DE, US. KHL@udel.edu.
Kelvin H
KH
Lee
D000818:Animals; D016466:CHO Cells; D060846:Cell Engineering; D064987:Cell- and Tissue-Based Therapy; D019295:Computational Biology; D006224:Cricetinae; D003412:Cricetulus; D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D016678:Genome; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans
Bioinformatics; Biomanufacturing; CHO cell; Genomics; Systems biology