Longitudinal cerebrovascular reactivity during pregnancy: a case study.
Normal cerebrovascular adaptation during pregnancy is poorly understood. We document a case study of progressively increased cerebrovascular reactivity to CO2, despite no change in resting blood flow, from prepregnancy to late gestation in a 36-year-old normotensive participant. Increased cerebral reactivity was related to progressive chronic respiratory alkalosis and specifically elevated pH and reduced HCO3(-). These novel data serve as important indicators of normative maternal cerebral adaptation and highlight novel areas of future study.
Program for Pregnancy and Postpartum Health, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB T6G 2E1, Canada., Physical Activity and Diabetes Lab, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB T6G 2H9, Canada.
Craig D
CD
Steinback
Emily C
EC
King
Margie H
MH
Davenport
D000328:Adult; D000472:Alkalosis, Respiratory / Q000503:physiopathology; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002245:Carbon Dioxide / Q000378:metabolism; D002319:Cardiovascular System / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011247:Pregnancy; D012137:Respiratory System / Q000378:metabolism; D012146:Rest
D002245:Carbon Dioxide
acid-base regulation; alcalose; alkalosis; cerebral blood flow; débit sanguin cérébral; grossesse; hypercapnia; hypercapnie; pregnant; rebreathing; régulation acidobasique; réinspiration