Bioactive metabolites from Cnidoscolus souzae and Acmella pilosa.
The bioassay-guided purification of the ethanol extracts of Acmella pilosa and Cnidoscolus souzae, two plants of the native flora of the Yucatan Peninsula used in traditional medicine to treat inflammation and pain, resulted in the identification of rosmarinic acid (1) and caffeic acid (2) as the bioactive metabolites from A. pilosa, and of 7-deoxynimbidiol (4) as the major bioactive metabolite from C. souzae. Metabolites 1, 2, and 4 proved to be responsible for the antioxidant activity originally detected in the corresponding organic crude extracts; 7-deoxynimbidiol (4) showed good analgesic and anti-inflammatory activities, inhibiting the pain induced by PGE2 and reducing the edema induced by carrageenan, respectively.
Hiatzy E
HE
Zapata-Estrella
Azeret D M
AD
Sánchez-Pardenilla
Karlina
K
García-Sosa
Fabiola
F
Escalante-Erosa
Fátima
F
de Campos-Buzzi
Nara Lins
NL
Meira-Quintão
Valdir
V
Cechinel-Filho
Luis M
LM
Peña-Rodríguez
D000700:Analgesics / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry* / Q000378:metabolism; D004487:Edema / Q000188:drug therapy / Q000276:immunology; D019665:Euphorbiaceae / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts