Unusual clear cell, lymphoplasmacyte-rich, dural-based tumor with divergent differentiation: a tricky case mimicking a meningioma.
We describe an unusual case of a recurrent dural neoplasm, previously diagnosed as meningioma. Histopathologically, the tumor is characterized by aggregates of divergently differentiated clear cells embedded in an abundant lymphoplasmacyte-rich stroma, mimicking a lymphoplasmacyte-rich meningioma. This study focuses on the histologic and immunohistochemical characterization of a unique dural-based tumor and provides useful guidelines for differentiating meningioma from other uncommon dural-based neoplasms. We propose that this recurrent dural neoplasm is a distinctive entity and, therefore, enlarges the spectrum of dural-based neoplasms that enter the differential diagnosis with meningiomas. Awareness of this tumor entity could prove useful for appropriate patient management.
Department of Medicine, Surgery, and Neuroscience, Section of Pathological Anatomy, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy.
Clelia
C
Miracco
Department of Medicine, Surgery, and Neuroscience, Section of Pathological Anatomy, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy.
Marzia
M
Toscano
Department of Medicine, Surgery, and Neuroscience, Section of Pathological Anatomy, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy. Electronic address: gbutorano2@hotmail.com.
Marie Aimée Gloria Munezero
MA
Butorano
Department of Medicine, Surgery, and Neuroscience, Section of Pathological Anatomy, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy.
Gennaro
G
Baldino
Department of Medicine, Surgery, and Neuroscience, Section of Pathological Anatomy, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy.
Damiana
D
Tacchini
Department of Medicine, Surgery, and Neuroscience, Section of Pathological Anatomy, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy.
Aurora
A
Barone
Department of Medicine, Surgery, and Neuroscience, Unit NINT Neuroimaging and Neurointervention, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy.
Alfonso
A
Cerase
D014408:Biomarkers, Tumor / Q000032:analysis*; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D004388:Dura Mater / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008579:Meningioma / Q000473:pathology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011237:Predictive Value of Tests
D014408:Biomarkers, Tumor
Clear cell tumor; Dural neoplasms; Histology; Immunohistochemistry; Meningioma