A new furan derivative from an endophytic Aspergillus flavus of Cephalotaxus fortunei.
A new furan derivative named 5-acetoxymethylfuran-3-carboxylic acid (2), together with a known furan compound, 5-hydroxymethylfuran-3-carboxylic acid (1), were isolated from the fermentation of Aspergillus flavus, endophytic fungi in Cephalotaxus fortunei. The structures of 1 and 2 were elucidated by NMR, IR, UV and MS data, as well as compared with literature data. The compounds 1 and 2 exhibited potent antibacterial activity against Staphylococcus aureus with MIC values of 31.3 and 15.6 μg/mL, respectively. The compound 2 showed moderate antioxidant activity.
a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology , Xi'an 710021 , P.R. China.
Yang-Min
YM
Ma
a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology , Xi'an 710021 , P.R. China.
Cong-Cong
CC
Ma
a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology , Xi'an 710021 , P.R. China.
Ting
T
Li
a Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology , Xi'an 710021 , P.R. China.
Jun
J
Wang
D000085:Acetates / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001231:Aspergillus flavus / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D032483:Cephalotaxus / Q000382:microbiology*; D005285:Fermentation; D005658:Fungi / Q000737:chemistry; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects
C000609225:5-acetoxymethylfuran-3-carboxylic acid; D000085:Acetates; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D005663:Furans; C039281:furan
5-acetoxymethylfuran-3-carboxylic acid; Aspergillus flavus; Cephalotaxus fortunei; furan derivative