Neonatal desensitization for the study of regenerative medicine.
Cell replacement is a therapeutic option for numerous diseases of the CNS. Current research has identified a number of potential human donor cell types, for which preclinical testing through xenotransplantation in animal models is imperative. Immune modulation is necessary to promote donor cell survival for sufficient time to assess safety and efficacy. Neonatal desensitization can promote survival of human donor cells in adult rat hosts with little impact on the health of the host and for substantially longer than conventional methods, and has subsequently been applied in a range of studies with variable outcomes. Reviewing these findings may provide insight into the method and its potential for use in preclinical studies in regenerative medicine.
Brain Repair Group, Sir Martin Evans Building, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.
Victoria H
VH
Roberton
Anne E
AE
Rosser
Claire M
CM
Kelly
D000328:Adult; D000818:Animals; D017690:Cell Transplantation / Q000379:methods*; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007231:Infant, Newborn; D008297:Male; D051381:Rats; D044968:Regenerative Medicine / Q000379:methods*
Huntington's disease; cell replacement; desensitization; immunosuppression; rejection; rodent models; transplantation; xenograft