Multibranched acquired periungual fibrokeratomas with confounding histopathologic findings resembling papillomavirus infection: a report of two cases.
Acquired periungual fibrokeratomas are benign fibrous tissue tumors and are considered as the topographical variant of acquired digital fibrokeratoma. They usually present as solitary tumors. In some instance, the entity may appear in multibranched fashion. The main histopathologic features consist of acanthosis, thick collagen bundles mainly oriented in a vertical axis forming a central core, and numerous proliferating fibroblasts. In this article, we present two cases of acquired multibranched periungual fibrokeratoma and depict their varying clinical features over time. Binucleation and perinuclear halos of keratinocytes mimicking human papillomavirus (HPV) infection were detected microscopically, but there was no reactivity with HPV immunostaining. In context, anti-HPV immunostaining may be helpful in the differentiation of fibrokeratomas from HPV infection. On the other hand, it should be kept in mind that these histopathologic findings may be found in acral biopsies independent of viral effects.
Department of Dermatology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.
Fatih
http://orcid.org/0000-0002-2380-7697
F
Göktay
Department of Dermatology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.
Zeynep Müeyyen
ZM
Altan
Department of Dermatology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.
Zeynep Büşra
ZB
Haras
Department of Pathology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.
Pembegül
P
Güneş
Department of Dermatology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.
Şirin
Ş
Yaşar
Department of Dermatology, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.
Sema
S
Aytekin
Department of Dermatology, Inselspital Bern University Hospital, Bern, Switzerland.
Eckart
E
Haneke
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000175:diagnosis / Q000473:pathology*; D005385:Fingers / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007642:Keratosis / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D009260:Nail Diseases / Q000175:diagnosis / Q000473:pathology*; D018218:Neoplasms, Fibrous Tissue / Q000175:diagnosis / Q000473:pathology; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000473:pathology*; D012871:Skin Diseases / Q000175:diagnosis / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology
HPV; fibrous tissue neoplasm; immunohistochemistry; nail disease