Involvement of epimutations in meningioma.
Epimutations are heritable and reversible cell markers, which can influence cell function going beyond the effects of DNA mutations. They result from multiple and coordinated mechanisms able to modulate gene expression. Regarding the significance of epigenetics in meningioma, few and somehow contradictory results are available, although promising information has been obtained. Here we highlight the most recent advances about the impact of DNA methylation, histone modifications, and microRNA regulation on meningioma development as well as the interplay between genetic and epigenetic alterations. Data indicate that epigenetics can help to identify novel candidate genes for the management and treatment of meningioma.
Department of Experimental Specialized Medical and Surgical and Odontostomatology Sciences, University of Messina, Messina, Italy.
Mario
M
Venza
Maria
M
Visalli
Concetta
C
Beninati
Teresa
T
Catalano
Carmelo
C
Biondo
Diana
D
Teti
Isabella
I
Venza
D000107:Acetylation; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000235:genetics*; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D042421:Histone Code / Q000235:genetics; D006801:Humans; D008577:Meningeal Neoplasms / Q000235:genetics*; D008579:Meningioma / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics; D058990:Molecular Targeted Therapy; D009154:Mutation / Q000235:genetics*
D004273:DNA, Neoplasm; D035683:MicroRNAs