Colon perforation and Budd-Chiari syndrome in Behçet's disease.
BACKGROUND
Behçet's disease is a chronic inflammatory disease involving multiple systems, with vasculitis being the most important pathological feature. Multiple colon perforations are thought to be secondary to vasculitis and they occur in patients with ulcers. These may be encountered within the entire colon but most commonly in the ileocecal region. Intestinal perforation and Budd-Chiari syndrome are infrequent in Behçet's disease, and are associated with high mortality and morbidity. Budd-Chiari syndrome results from occlusion of either hepatic veins or adjacent inferior vena cava, or both.


METHODS
We report a patient with Behçet's disease having multiple perforations in the transverse colon, descending colon, and sigmoid colon. The patient also had Budd-Chiari syndrome due to inferior vena cava thrombosis extending into the right and middle hepatic vein. Our observations are presented with a review of the literature.


CONCLUSIONS
In Behçet's disease, treatment of colon perforation necessitates urgent surgery, whereas management of Budd-Chiari syndrome is directed towards the underlying cause. Behçet's disease, as a chronic multisystemic disease with various forms of vasculitis, is resistant to medical and surgical treatment. Prognosis is worse in Behçet's disease with colon perforation than that in Budd-Chiari syndrome alone.
Department of Pathology, Hitit University, Faculty of Medicine, Çorum, Turkey.
Yılmaz
Y
Baş
Department of Pathology, Hitit University, Faculty of Medicine, Çorum, Turkey.
Güven
G
Güney
Department of Pathology, Hitit University, Faculty of Medicine, Çorum, Turkey.
Pınar
P
Uzbay
Department of General Surgery, Hitit University, Faculty of Medicine, Çorum, Turkey.
Ethem
E
Zobacı
Department of Radiology, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Selin
S
Ardalı
Department of Microbiology, Hitit University, Faculty of Medicine, Çorum, Turkey.
Ayşegül Taylan
AT
Özkan
D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000175:diagnosis; D006502:Budd-Chiari Syndrome / Q000150:complications* / Q000175:diagnosis; D003082:Colectomy; D003108:Colonic Diseases / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D003113:Colonoscopy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D012422:Rupture, Spontaneous; D014057:Tomography, X-Ray Computed