The risk factors for mortality and septic shock in liver transplant recipients with ESKAPE bacteremia.
OBJECTIVE
Although bacteremias due to the six ESKAPE pathogens have recently been identified as a serious emerging problems in solid organ transplant (SOT), no information in liver transplant recipients is available. We sought to investigate the risk factors for mortality and septic shock in liver transplant recipients with ESKAPE bacteremia.


METHODS
A retrospective analysis of bacteremia after liver transplantation was reviewed. Risk factors for mortality and septic shock caused by ESKAPE bacteremia were identified.


RESULTS
Forty-nine episodes ofbacteremia in 37 liver transplant recipients were due to ESKAPE strains. The only factor for bacteremia-related mortality independently associated with ESKAPE was septic shock (odds ratio [OR] = 67.500, 95% confidence interval [CI] = 8.464-538.300, P < .001). The factors for septic shock independently associated with ESKAPE were white blood cells count > 15,000/mm3 (OR = 15.205, 95% CI = 2.271-101.799, P = .005) and temperature of 39 °C or greater (OR = 10.959, 95% CI = 1.592-75.450, P = .015).


CONCLUSIONS
To improve the results of liver transplantation, more effectively therapeutic treatments are of paramount importance when liver transplant recipients with ESKAPE bacteremia present with septic shock, elevated white blood cells count and high body temperature.
Wen
W
Ouyang
Xiaoxiao
X
Li
Qiquan
Q
Wan
Qifa
Q
Ye
D040981:Acinetobacter baumannii / Q000302:isolation & purification / Q000472:pathogenicity; D000328:Adult; D016470:Bacteremia / Q000097:blood / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality*; D016009:Chi-Square Distribution; D002681:China; D004754:Enterobacter / Q000302:isolation & purification; D016984:Enterococcus faecium / Q000302:isolation & purification / Q000472:pathogenicity; D005260:Female; D006801:Humans; D007711:Klebsiella pneumoniae / Q000302:isolation & purification / Q000472:pathogenicity; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification / Q000472:pathogenicity; D012189:Retrospective Studies; D012307:Risk Factors; D012772:Shock, Septic / Q000097:blood / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality*; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000472:pathogenicity; D066027:Transplant Recipients; D016896:Treatment Outcome