Association between new onset diabetic retinopathy and monocyte chemoattractant protein-1 (MCP-1) polymorphism in Japanese type 2 diabetes.
We longitudinally evaluated the association between monocyte chemoattractant protein-1 (MCP-1) A-2518G polymorphism and new onset of diabetic retinopathy in 758 type 2 diabetic patients. The new onset of retinopathy increased with the increase of the number of G alleles, even after adjustment for age, HbA1c levels, and duration of diabetes.
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Hiroyo
H
Ninomiya
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Electronic address: katakami@endmet.med.osaka-u.ac.jp.
Naoto
N
Katakami
Naka Memorial Clinic, Naka, Ibaraki, Japan.
Takeshi
T
Osonoi
Naka Memorial Clinic, Naka, Ibaraki, Japan.
Miyoko
M
Saitou
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Yuichi
Y
Yamamoto
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Mitsuyoshi
M
Takahara
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Dan
D
Kawamori
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Taka-aki
TA
Matsuoka
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Yoshimitsu
Y
Yamasaki
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Iichiro
I
Shimomura
D000368:Aged; D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D018932:Chemokine CCL2 / Q000235:genetics*; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
C111835:CCL2 protein, human; D018932:Chemokine CCL2
MCP-1; Retinopathy; SNP