IBD. Fishing for missing heritability in IBD.
A genetic predisposition to IBD is widely accepted; however IBD heritability is dependent on more than the simple additive risk of genetic variants. In a new study using zebrafish, convincing evidence is presented that alterations in the epigenetic regulation of TNF might contribute to the "missing heritability" of IBD.
Department of Medicine and Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA.
Michael
M
Pack
D000818:Animals; D019175:DNA Methylation; D044127:Epigenesis, Genetic / Q000502:physiology*; D015212:Inflammatory Bowel Diseases / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000196:embryology*; D015027:Zebrafish / Q000196:embryology*