MTNR1B gene polymorphisms and susceptibility to Type 2 Diabetes: A pilot study in South Indians.
Type 2 Diabetes (T2D) is the major health concern in the Indian subcontinent. A genome-wide association study carried out with non-diabetic Indians showed association of MTNR1B variants with fasting glucose. MTNR1B mediates the effect of melatonin on insulin secretion. In light of the growing importance of MTNR1B in the etiology of T2D, we sought to test its association with the disease in the south Indian type 2 diabetics. Five single nucleotide polymorphisms of MTNR1B (rs10830962, rs10830963, rs3847554, rs1387153 and rs2166706) were genotyped in 346 T2D patients and 341 non-diabetic controls. None of the SNPs differed significantly between patients and controls with respect to allele and genotype frequencies. Linear regression analysis after adjustment for age, sex and BMI showed a significant positive association of rs3847554 with fasting glucose under recessive model (β=14.98, p=0.012). Haplotypes constituted by minor alleles of rs3847554, rs1387153, rs2166706, rs10830963 and major allele of rs10830962 showed significant positive correlation with fasting glucose (p<0.05). Though the results obtained are suggestive of MTNR1B role in T2D etiology, they need to be confirmed with much larger sample sizes.
Anthropological Survey of India, Southern Regional Centre, Mysore 570026, Karnataka, India; Department of Studies in Biochemistry, University of Mysore, Mysore 570006, Karnataka, India. Electronic address: Salman.biochem@gmail.com.
Mohammed
M
Salman
Department of Studies in Biotechnology, University of Mysore, Mysore 570006, Karnataka, India. Electronic address: shrutidg@gmail.com.
Shruti
S
Dasgupta
Department of Anthropology, Division of Human Genetics, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India. Electronic address: arja.genetics@gmail.com.
A
A
Cholendra
Anthropological Survey of India, North-West Regional Center, Dehradun 248 195, India. Electronic address: saivenug@yahoo.com.
P N
PN
Venugopal
Anthropological Survey of India, Southern Regional Centre, Mysore 570026, Karnataka, India. Electronic address: lakshmigl.14@gmail.com.
G L
GL
Lakshmi
Anthropological Survey of India, Southern Regional Centre, Mysore 570026, Karnataka, India. Electronic address: xavasu@yahoo.com.
D
D
Xaviour
Anthropological Survey of India, Southern Regional Centre, Mysore 570026, Karnataka, India. Electronic address: jadhavjsrao@gmail.com.
Jayashankar
J
Rao
Department of Studies in Biochemistry, University of Mysore, Mysore 570006, Karnataka, India. Electronic address: Cletus@biochemistry.uni-mysore.ac.in.
Cletus J M
CJ
D'Souza
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D006801:Humans; D007194:India; D008875:Middle Aged; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D044123:Receptor, Melatonin, MT2 / Q000235:genetics*
C573871:MTNR1B protein, human; D044123:Receptor, Melatonin, MT2
Fasting glucose; MTNR1B gene; Single nucleotide polymorphisms; South India; Type 2 Diabetes