Cucurbit[6]uril is an ultrasensitive (129)Xe NMR contrast agent.
A lack of molecular contrast agents has slowed the application of ultrasensitive hyperpolarized (129)Xe NMR methods. Here, we report that commercially available cucurbit[6]uril (CB[6]) undergoes rapid xenon exchange kinetics at 300 K, and is detectable by Hyper-CEST NMR at 1.8 pM in PBS and at 1 μM in human plasma where many molecules, including polyamines, can compete with xenon for CB[6] binding.
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. ivandmo@sas.upenn.edu.
Yanfei
Y
Wang
Ivan J
IJ
Dmochowski
D001952:Bridged-Ring Compounds / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013696:Temperature; D014867:Water / Q000737:chemistry; D014978:Xenon / Q000737:chemistry*; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D001952:Bridged-Ring Compounds; D003287:Contrast Media; D007093:Imidazoles; D014867:Water; D014978:Xenon; C454805:cucurbit(6)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils