Metabonomic Study of the Effects of Acanthopanax senticosus on Peripheral System of Rats.
Acanthopanax senticosus is extensively used to treat various nervous and cerebrovascular diseases in traditional medicinal systems in China and Russia. Ultrahigh-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry coupled with pattern recognition methods was used to investigate the effects of A. senticosus on the peripheral system in rats. The analysis of possible pathways influenced by A. senticosus was performed with MetaboAnalyst and Cytoscape software. After treatment with A. senticosus, 21 modulated metabolites in heart tissue, 20 in liver tissue, 14 in spleen tissue, 17 in lung tissue, 16 in kidney tissue, and 12 in a serum sample were identified and considered potential biomarkers of A. senticosus treatments. The regulation of some endogenous metabolites by A. senticosus could be beneficial for the treatment of several peripheral system diseases, such as hypertension, cancer, and oxidative stress, etc. However, there were also some upregulated endogenous metabolites producing potential toxicity to the peripheral system. A metabonomic analysis revealed that protection and toxicity coexisted in the effects of A. senticosus on the peripheral system, which may be a practical guide for its safe use and beneficial to the expansion of its application.
Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, P. R. China.
Shuai-nan
SN
Zhang
Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, P. R. China.
Xu-zhao
XZ
Li
Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, P. R. China.
Shu-min
SM
Liu
Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin, P. R. China.
Fang
F
Lu
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D028001:Eleutherococcus / Q000737:chemistry*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D055432:Metabolomics; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
D015415:Biomarkers; D010936:Plant Extracts