Preliminary findings of arterial embolization with balloon-occluded and flow-dependent histoacryl glue embolization in a swine model.
OBJECTIVE
To evaluate the potential usefulness of the balloon-occluded histoacryl glue embolization (B-glue) technique.


METHODS
Both flow-dependent (no balloon occlusion) and B-glue techniques were used for 24 intercostal arteries of two female swine. N-butyl 2-cyanoacrylate (NBCA) was diluted with lipiodol to a 50 % solution, which was infused after occluding the arteries with microballoon catheters. The embolization range, fragmentation, reflux, adhesion, and glue particle attachment were compared between flow-dependent and B-glue techniques.


RESULTS
The B-glue technique was performed in a controlled fashion resulting in successful arterial occlusion without fragmented migration of the injected glue cast. Reflux occurred less frequently with the B-glue technique and was significantly different (p = 0.039) [Corrected] from that for the flow-dependent technique. Catheters were safely removed from the arterial walls, although in one instance (8.3 %), large glue particles were found to be attached to the catheter tip on removal. Conversely, the flow-dependent technique was more difficult to control and resulted in several instances of higher rates of fragmentation.


CONCLUSIONS
The B-glue technique can efficiently control NBCA delivery with lower rates of reflux.
Department of Radiology, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki, 216-8511, Japan, hal29120@me.com.
Shingo
S
Hamaguchi
Brandon D
BD
Lohman
Yukihisa
Y
Ogawa
Yasunori
Y
Arai
Kazuki
K
Hashimoto
Junichi
J
Matsumoto
Yasuo
Y
Nakajima
D000269:Adhesives / Q000008:administration & dosage*; D000818:Animals; D021721:Balloon Occlusion / Q000379:methods; D003287:Contrast Media; D004621:Embolization, Therapeutic / Q000379:methods*; D004659:Enbucrilate / Q000008:administration & dosage*; D004998:Ethiodized Oil; D005260:Female; D023421:Models, Animal; D013552:Swine
D000269:Adhesives; D003287:Contrast Media; D004998:Ethiodized Oil; D004659:Enbucrilate