Cost of treatment in patients with metastatic soft tissue sarcoma who respond favourably to chemotherpy. The SArcoma treatment and Burden of Illness in North America and Europe (SABINE) study.
Treatment of metastatic soft tissue sarcoma (mSTS) commonly includes multiple lines of chemotherapy, until a decline in performance status precludes further treatment. The primary objective of this study was to describe the lifetime healthcare resource utilisation and cost among mSTS patients with favourable response to chemotherapy. SABINE was a multi-centre (n = 25), multi-country (n = 9) retrospective chart review study of mSTS patients with favourable response to chemotherapy following 4 cycles. Healthcare resource utilisation was collected from first line until death or end of follow-up. Costs were analysed by health states (defined by treatment line, chemotherapy use and disease progression) and estimated by multiplying the mean weekly cost per health state by the expected number of weeks spent in each health state. Expected per-patient lifetime medical cost was €65 616 (95% CI: €51 454-€85 003); comprised of IV chemotherapy (31.7%), inpatient care (24.8%), concomitant medication (11.0%), oral chemotherapy (8.9%), outpatient visits (8.8%), radiotherapy (6.3%), hospice (4.0%), imaging (3.7%) and laboratory (0.7%). Weekly costs were 280-330% higher during chemotherapy treatment periods than off-chemotherapy, especially after disease progression. Per-patient costs were highest in the USA and lowest in the Netherlands and UK. The economic burden of mSTS is considerable and the amount of resources devoted to its treatment varies across countries.
Department of Neurobiology, Care Sciences and Society, Karolinska Institut, Stockholm.
L
L
Jönsson
Mapi Group, Stockholm, Sweden.
N
N
Justo
Medtronic, Tolochenaz, Switzerland.
A
A
Musayev
Novartis Pharmaceuticals Corporation, Florham Park, NJ, USA.
A
A
Krishna
Global Health Outcomes, Oncology, Global Health Outcomes, Merck, Whitehouse Station, NJ, USA.
T
T
Burke
Merck Research Laboratories, Merck & Co., Inc., Upper Gwynedd, PA, USA.
J
J
Pellissier
Royal Marsden Hospital, London, UK.
I
I
Judson
Abramson Cancer Center, Pennsylvania Hospital, Philadelphia, PA, 19106, USA.
A
A
Staddon
Centre Léon Bérard, University Claude Bernard Lyon I, Lyon Cedex, France.
J Y
JY
Blay
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000191:economics* / Q000627:therapeutic use; D002170:Canada; D002986:Clinical Trials as Topic; D017281:Cost of Illness; D005060:Europe; D005260:Female; D017048:Health Care Costs; D006295:Health Resources / Q000191:economics / Q000706:statistics & numerical data; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012189:Retrospective Studies; D012509:Sarcoma / Q000188:drug therapy / Q000191:economics*; D014481:United States; D055815:Young Adult
chemotherapy; cost; duration; healthcare resource utilisation; mSTS; soft tissue sarcoma