DNA interaction and efficient antimicrobial activities of 4N chelating metal complexes.
A new series of metal(II) complexes using a symmetric Schiff base ligand, obtained by the condensation reaction of 4-formyl-N,N-dimethylaniline with benzene-1,2-diamine were synthesized and characterized. The various physico-chemical data indicate that the complexes have octahedral geometry. The intrinsic binding constant of the complexes with DNA is explored. The UV-Vis., circular dichorism, fluorescence emission spectral data and the viscosity measurements indicate that the complexes bind to calf thymus DNA (CT DNA) by intercalative mode. The intrinsic binding constants of Cu(II), Ni(II), Co(II) and Zn(II) complexes are found to be 7.1×10(4), 5.2×10(4), 1.8×10(5) and 6.3×10(4) M(-1), respectively. The cleavage studies of these complexes are investigated by gel electrophoresis method in the presence of peroxide. The complexes exhibit enhanced biological activities compared to the free ligand.
Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India.
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S
Packianathan
Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India.
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T
Arun
Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, India. Electronic address: ramchem1964@gmail.com.
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N
Raman
D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D002417:Cattle; D002614:Chelating Agents / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D008670:Metals / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D012545:Schiff Bases / Q000737:chemistry*
D000814:Aniline Compounds; D000890:Anti-Infective Agents; D002614:Chelating Agents; D056831:Coordination Complexes; D007364:Intercalating Agents; D008024:Ligands; D008670:Metals; D012545:Schiff Bases; C015157:N,N-dimethylaniline; D004247:DNA; C427203:calf thymus DNA