[Individualized, personalized and stratified medicine: a challenge for allergology in ENT?].
Individualized, personalized or stratified medicine approaches offer emerging opportunities in the field of allergy and ENT. Avoidance of side effects, targeted therapy approaches and stratified prevention promise better outcomes and optimal results for patients. Conceptual incongruencies remain with regard to definitions and perceptions of "personalized medicine". Serious ethical considerations have to be taken into account. The development of pharmacogenomics, molecular phenotyping, genomic sequencing and other -omics opens the door to unique mechanistic therapeutic advances. The molecular allergology and recombinant diagnostics available are tools that offer substantial improved diagnostics for the benefit of allergic patients, e. g. in anaphylaxis and food allergy. For stratified therapeutic approaches, however, regulatory affairs will have to keep pace with medical and scientific discovery.
HNO-Klinik und ZAUM, Klinikum rechts der Isar, Technische Universität München, München, Deutschland.
Adam M
AM
Chaker
L
L
Klimek
D000486:Allergy and Immunology / Q000941:ethics; D005820:Genetic Testing / Q000941:ethics*; D015316:Genetic Therapy / Q000941:ethics*; D005858:Germany; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D010036:Otolaryngology / Q000941:ethics*; D057285:Precision Medicine / Q000941:ethics*