Agents that inhibit bacterial biofilm formation.
In the biofilm form, bacteria are more resistant to various antimicrobial treatments. Bacteria in a biofilm can also survive harsh conditions and withstand the host's immune system. Therefore, there is a need for new treatment options to treat biofilm-associated infections. Currently, research is focused on the development of antibiofilm agents that are nontoxic, as it is believed that such molecules will not lead to future drug resistance. In this review, we discuss recent discoveries of antibiofilm agents and different approaches to inhibit/disperse biofilms. These new antibiofilm agents, which contain moieties such as imidazole, phenols, indole, triazole, sulfide, furanone, bromopyrrole, peptides, etc. have the potential to disperse bacterial biofilms in vivo and could positively impact human medicine in the future.
Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, USA.
Nira
N
Rabin
Yue
Y
Zheng
Clement
C
Opoku-Temeng
Yixuan
Y
Du
Eric
E
Bonsu
Herman O
HO
Sintim
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D018441:Biofilms / Q000187:drug effects*; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D008826:Microbial Sensitivity Tests; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D054852:Small Molecule Libraries