New inflammatory markers for prediction of non-dipper blood pressure pattern in patients with essential hypertension: Serum YKL-40/Chitinase 3-like protein 1 levels and echocardiographic epicardial adipose tissue thickness.
The aim of the present study was to investigate whether YKL-40 levels and epicardial adipose tissue (EAT) thickness were associated with non-dipping pattern in essential hypertension (HT). Age- and sex-matched 40 dipper hypertensive patients and 40 non-dipper hypertensive patients were included in the study. Non-dippers had significantly increased EAT thickness and higher YKL-40 and high-sensitivity C-reactive protein levels than dippers. Multivariate logistic regression analysis showed that the EAT thickness and serum levels of YKL-40 and high-sensitivity C-reactive protein were independent predictors of non-dipping pattern in essential HT. In essential HT, presence of non-dipping pattern is associated with increased inflammatory response.
a Department of Cardiology .
Eftal Murat
EM
Bakirci
a Department of Cardiology .
Husnu
H
Degirmenci
a Department of Cardiology .
Hikmet
H
Hamur
b Department of Biochemistry , and.
Murat
M
Gunay
c Department of Microbiology, Faculty of Medicine , Erzincan University , Erzincan , Turkey.
Barıs
B
Gulhan
c Department of Microbiology, Faculty of Medicine , Erzincan University , Erzincan , Turkey.
Merve
M
Aydin
a Department of Cardiology .
Zafer
Z
Kucuksu
a Department of Cardiology .
Gokhan
G
Ceyhun
a Department of Cardiology .
Ergun
E
Topal
D054392:Adipokines / Q000097:blood*; D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D002097:C-Reactive Protein / Q000378:metabolism; D000071451:Chitinase-3-Like Protein 1; D003430:Cross-Sectional Studies; D004452:Echocardiography / Q000379:methods*; D000075222:Essential Hypertension; D005260:Female; D006023:Glycoproteins; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging*
D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D037102:Lectins; D002097:C-Reactive Protein
Dipper; YKL-40; epicardial adipose tissue; inflammation; non-dipper