The history and market impact of CRISPR RNA-guided nucleases.
The interface between viruses and their hosts' are hot spots for biological and biotechnological innovation. Bacteria use restriction endonucleases to destroy invading DNA, and industry has exploited these enzymes for molecular cut-and-paste reactions that are central to many recombinant DNA technologies. Today, another class of nucleases central to adaptive immune systems that protect bacteria and archaea from invading viruses and plasmids are blazing a similar path from basic science to profound biomedical and industrial applications.
Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.
Paul Bg
PB
van Erp
Technology Transfer Office, Montana State University, Bozeman, MT 59717, USA.
Gary
G
Bloomer
Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA.
Royce
R
Wilkinson
Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA. Electronic address: bwiedenheft@gmail.com.
Blake
B
Wiedenheft
D064130:CRISPR-Associated Proteins / Q000378:metabolism*; D064113:CRISPR-Cas Systems; D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D004706:Endodeoxyribonucleases / Q000378:metabolism*; D005818:Genetic Engineering / Q000191:economics
D064130:CRISPR-Associated Proteins; D004706:Endodeoxyribonucleases