Cerebrovascular Diseases in Workers at Mayak PA: The Difference in Radiation Risk between Incidence and Mortality.
A detailed analysis of cerebrovascular diseases (CeVD) for the cohort of workers at Mayak Production Association (PA) is presented. This cohort is especially suitable for the analysis of radiation induced circulatory diseases, due to the detailed medical surveillance and information on several risk factors. The risk after external, typically protracted, gamma exposure is analysed, accounting for potential additional internal alpha exposure. Three different endpoints have been investigated: incidence and mortality from all cerebrovascular diseases and incidence of stroke. Particular emphasis was given to the form of the dose-response relationship and the time dependence of the radiation induced risk. Young attained age was observed to be an important, aggravating modifier of radiation risk for incidence of CeVD and stroke. For incidence of CeVD, our analysis supports a dose response sub-linear for low doses. Finally, the excess relative risk per dose was confirmed to be significantly higher for incidence of CeVD compared to CeVD mortality and incidence of stroke. Arguments are presented for this difference to be based on a true biological effect.
Helmholtz Zentrum München, Department of Radiation Sciences, Neuherberg, Germany.
Cristoforo
C
Simonetto
Helmholtz Zentrum München, Department of Radiation Sciences, Neuherberg, Germany.
Helmut
H
Schöllnberger
Southern Urals Biophysics Institute (SUBI), Ozyorsk, Chelyabinsk Region, Russia.
Tamara V
TV
Azizova
Southern Urals Biophysics Institute (SUBI), Ozyorsk, Chelyabinsk Region, Russia.
Evgenia S
ES
Grigoryeva
Southern Urals Biophysics Institute (SUBI), Ozyorsk, Chelyabinsk Region, Russia.
Maria V
MV
Pikulina
Helmholtz Zentrum München, Department of Radiation Sciences, Neuherberg, Germany.
Markus
M
Eidemüller
D000016:Abnormalities, Radiation-Induced / Q000453:epidemiology* / Q000503:physiopathology; D000368:Aged; D000369:Aged, 80 and over; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D054043:Nuclear Weapons; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D016273:Occupational Exposure; D011005:Plutonium / Q000009:adverse effects; D012307:Risk Factors
D011005:Plutonium