Association of systolic dysfunction with left ventricular hypertrophy and diastolic dysfunction in hypertensive patients.
BACKGROUND
the presence of systolic dysfunction has not been well recognized in hypertensive patients (p).


OBJECTIVE
The aim of this study is to demonstrate that hypertensive p with left ventricular hypertrophy (LVH) have systolic dysfunction, and that this functional alteration increases when it is associated to diastolic dysfunction (DD).


METHODS
descriptivecross-sectional studywith aprospectivelycollected sample according to specified inclusion and exclusion criteria. Left ventricular function was evaluated with conventional echocardiography, mitral valvular orifice Doppler and tissue Doppler following international guidelines. The p were divided in four groups by the presence or absence of LVH and DD.


METHODS
students t tests and ANOVA test, statistical significance <0,05.


RESULTS
292 p were included, 130 p (51 %) LVH- DD-; 36 p (5,9 %) LVH- DD+; 87 p (37,6 %) LVH+ DD-; and 39 p (5,5 %) LVH+ DD+. Patients with diastolic dysfunction were older and more frequently of female sex, had greater systolic blood pressure and central aortic systolic blood pressure. The shortening rate of longitudinal myocardial fibers measured by tissue Doppler (s wave) were 6,3 +1,1 cm/sec in LVH+ DD+ p, 7,2+1,3 cm/sec in LVH+ DD- p, 6,8+1,2 cm/sec in LVH- DD+ p, and 7,8+0,6 cm/seg in LVH- DD- p (<0,005).


CONCLUSIONS
hypertensives p had systolic dysfunction when LVH is present and it is greater when it is associated to DD.
Daniel
D
Piskorz
Laureano
L
Bongarzoni
Luciano
L
Citta
Norberto
N
Citta
Paula
P
Citta
Luis
L
Keller
Alicia
A
Tommasi
D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D062186:Arterial Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler; D005260:Female; D054144:Heart Failure, Diastolic / Q000503:physiopathology*; D054143:Heart Failure, Systolic / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D012737:Sex Factors; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology