Importance of resectability status in neoadjuvant treatment for pancreatic cancer.
BACKGROUND
Much attention has been paid to neoadjuvant treatment (NAT) as a new strategy especially for borderline resectable pancreatic cancer (BRPC). However, the optimal indication of NAT remains undetermined.


METHODS
We analyzed 248 patients with pancreatic cancer (PC). One hundred resectable tumors were classified as R group. Sixty-nine tumors with venous involvement were classified as BR-P group, while 31 tumors with arterial involvement were classified as BR-A group. Ninety-nine patients received NAT. Furthermore, 48 unresectable locally advanced PC served as controls (LAPC group). Among them, 11 patients received adjuvant surgery afterwards (Ad-surg group).


RESULTS
The overall median survival time in the R, BR-P and BR-A groups was 45.3, 24.8 and 16.8 months. In the R and BR-P groups, patients treated with NAT had a better prognosis than those without. In contrast, NAT had no impact on prognosis in the BR-A group. Patients treated with NAT in the BR-P, but not BR-A group, had a better prognosis than patients in the LAPC group. Furthermore, patients in the Ad-surg group had a significantly better prognosis than patients in the BR-A group.


CONCLUSIONS
Borderline resectable pancreatic cancer with venous involvement, but without arterial involvement, may be a good indication for NAT. Our data highlight the importance of preoperative resectability assessment to evaluate the indication and efficacy of NAT.
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Masayuki
M
Sho
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Takahiro
T
Akahori
Department of Radiology, Nara Medical University, Kashihara, Nara, Japan.
Toshihiro
T
Tanaka
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Shoichi
S
Kinoshita
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Minako
M
Nagai
Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan.
Tetsuro
T
Tamamoto
Department of Diagnostic Pathology, Nara Medical University, Kashihara, Nara, Japan.
Chiho
C
Ohbayashi
Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan.
Masatoshi
M
Hasegawa
Department of Radiology, Nara Medical University, Kashihara, Nara, Japan.
Kimihiko
K
Kichikawa
Department of Surgery, Nara Medical University, Kashihara, Nara, Japan.
Yoshiyuki
Y
Nakajima
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome
Adjuvant treatment; Borderline resectable; Neoadjuvant treatment; Pancreatic cancer; Surgery