Combination Systemic Fluorouracil and Radiation for the Treatment of Recalcitrant Condyloma with Associated Squamous Cell Carcinoma in an Immunocompromised 15-Year-Old Girl.
Condylomata acuminata (CA), or anogenital warts, are typically benign lesions caused by human papillomavirus infection. Although they are rare, immunocompromised individuals are at a higher risk of CA undergoing transformation into invasive anal squamous cell carcinoma (SCC). These patients need aggressive evaluation and management. Treatment of CA is challenging, particularly for immunocompromised hosts, in whom warts are resistant to treatment and commonly recur. Currently, there is no gold standard treatment for CA, especially in children and immunodeficient individuals. We report the case of a 15-year-old immunocompromised girl with severe recalcitrant condyloma that resolved after a course of systemic 5-fluorouracil, mitomycin C, and radiation therapy for SCC.
Massachusetts General Hospital, Boston, Massachusetts.
Suchismita
S
Paul
Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.
Carol E
CE
Cheng
Massachusetts General Hospital, Boston, Massachusetts.
Daniela
D
Kroshinsky
D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D015704:CD4 Antigens / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy* / Q000821:virology; D059248:Chemoradiotherapy; D003218:Condylomata Acuminata / Q000473:pathology / Q000628:therapy* / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005831:Genital Diseases, Female / Q000473:pathology / Q000628:therapy* / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000473:pathology / Q000628:therapy* / Q000821:virology; D049268:Positron-Emission Tomography; D014846:Vulvar Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology
D000964:Antimetabolites, Antineoplastic; D015704:CD4 Antigens; D005472:Fluorouracil