Continuous wound infusion of ropivacaine for the control of pain after thoracolumbar spinal surgery: a randomized clinical trial.
A prospective randomized clinical trial was carried out to observe the analgesic efficacy of ropivacaine for postoperative pain following thoracolumbar spinal surgery.



Seventy-one patients with elective posterior thoracolumbar spinal surgery were randomly divided into two groups. Local group received 0.33 % ropivacaine by pump through the wound, and intravenous group received flurbiprofen axetil, pentazocine and palonosetron via intravenous pump. We evaluated the level of pain, the incidence of adverse reactions at 2, 4, 6, 12, 24, 36 and 48 h after operation, and the occurrence of chronic pain 3 months later.



There were no significant differences in the pain level between the two groups. However, the incidence of nausea, vomiting and chronic pain was significantly lower in the local group.



Our results showed that local infusion of ropivacaine achieved similar analgesic effects to intravenous delivery of analgesic drugs, but significantly reduced incidence of nausea, vomiting and chronic pain.
Department of Anesthesiology, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China. xubo333@hotmaill.com.
Bo
B
Xu
Department of Anesthesiology, Zhuhai People's Hospital, Zhuhai, 519000, China.
Li
L
Ren
Department of Anesthesiology, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China. gzzyyubox@gmail.com.
Weifeng
W
Tu
Department of Orthopedics, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China.
Zenghui
Z
Wu
Department of Orthopedics, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China.
Fuzhi
F
Ai
Department of Anesthesiology, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China.
Dongxu
D
Zhou
Department of Anesthesiology, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China.
Biyun
B
Chen
Department of Anesthesiology, General Hospital of Guangzhou Military Command, Guangzhou, 510010, China.
Xingan
X
Zhang
D000577:Amides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D019637:Orthopedic Procedures / Q000009:adverse effects / Q000706:statistics & numerical data; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy / Q000453:epidemiology; D000077212:Ropivacaine; D013904:Thoracic Vertebrae / Q000601:surgery*
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine
Chronic pain; Local analgesia; Postoperative pain; Ropivacaine; Thoracolumbar spinal surgery