Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells.
Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[{[2-(dimethylamino)ethyl]imino}methyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent Co(II) and Co(III) ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15K and then reaches to the value 1.56 cm(3) K mol(-1) at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.
Department of Physics, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir, Turkey. Electronic address: amitd_ju@yahoo.co.in.
Amitabha
A
Datta
Department of Chemistry, Inorganic Chemistry Section, Jadavpur University, Kolkata 700032, India.
Kuheli
K
Das
Department of Chemistry, Inorganic Chemistry Section, Jadavpur University, Kolkata 700032, India.
Chandana
C
Sen
Department of Chemistry, Inorganic Chemistry Section, Jadavpur University, Kolkata 700032, India.
Nirmal Kumar
NK
Karan
Department of Chemistry, National Changhua University of Education, Changhua 50058, Taiwan. Electronic address: juihuang@cc.ncue.edu.tw.
Jui-Hsien
JH
Huang
Department of Chemistry, Chung-Yuan Christian University, Chun-Li 320, Taiwan.
Chia-Her
CH
Lin
Dipartimento di Chimica and Centro Interdisciplinare per lo Sviluppo della Ricerca Biotecnologica e per lo Studio della Biodiversità della Sardegna, Università di Sassari, Via Vienna 2, I-07100 Sassari, Italy.
Eugenio
E
Garribba
Department of Chemistry, Inorganic Chemistry Section, Jadavpur University, Kolkata 700032, India. Electronic address: c_r_sinha@yahoo.com.
Chittaranjan
C
Sinha
Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir, Turkey.
Tulin
T
Askun
Department of Biology, Faculty of Sciences and Arts, University of Balikesir, Cagis Campus, 10145 Balikesir, Turkey.
Pinar
P
Celikboyun
Institute of Chemistry, Academia Sinica, Nangang - 11529, Taipei, Taiwan.
Sandeep B
SB
Mane
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D002277:Carcinoma / Q000188:drug therapy; D045744:Cell Line, Tumor; D003035:Cobalt / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006801:Humans; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014376:Tuberculosis / Q000188:drug therapy
D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D056831:Coordination Complexes; D003035:Cobalt
Anti-mycobacterial activity; Co complex; Crystal structure; EPR; Inhibitory effect; VTM