Complicating autoimmune diseases in myasthenia gravis: a review.
Myasthenia gravis (MG) is a rare autoimmune disease of skeletal muscle endplates. MG subgroup is relevant for comorbidity, but usually not accounted for. MG patients have an increased risk for complicating autoimmune diseases, most commonly autoimmune thyroid disease, systemic lupus erythematosus and rheumatoid arthritis. In this review, we present concomitant autoimmune disorders associated with the different MG subgroups, and show how this influences treatment and prognosis. Concomitant MG should always be considered in patients with an autoimmune disorder and developing new neuromuscular weakness, fatigue or respiratory failure. When a second autoimmune disorder is suspected, MG should be included as a differential diagnosis.
a Department of Neurology , Haukeland University Hospital , Bergen , Norway .
Aliona
A
Nacu
Jintana Bunpan
JB
Andersen
Vitalie
V
Lisnic
Jone Furlund
JF
Owe
Nils Erik
NE
Gilhus
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications*; D015551:Autoimmunity; D020022:Genetic Predisposition to Disease; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000276:immunology; D009157:Myasthenia Gravis / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology; D011978:Receptors, Nicotinic / Q000276:immunology; D013945:Thymoma / Q000150:complications
D001323:Autoantibodies; D001324:Autoantigens; D026502:LDL-Receptor Related Proteins; C551781:LRP4 protein, human; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases
Autoimmune disease; comorbidity; myasthenia gravis