How do voltage-gated sodium channels enhance migration and invasiveness in cancer cells?
Voltage-gated sodium channels are abnormally expressed in tumors, often as neonatal isoforms, while they are not expressed, or only at a low level, in the matching normal tissue. The level of their expression and their activity is related to the aggressiveness of the disease and to the formation of metastases. A vast knowledge on the regulation of their expression and functioning has been accumulated in normal excitable cells. This helped understand their regulation in cancer cells. However, how voltage-gated sodium channels impose a pro-metastatic behavior to cancer cells is much less documented. This aspect will be addressed in the review. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers.
Inserm UMR1069 "Nutrition, Croissance et Cancer", Faculté de Médecine, Université François Rabelais de Tours, France; Faculté de Sciences Pharmaceutiques, Université François Rabelais de Tours, France. Electronic address: pierre.besson@univ-tours.fr.
Pierre
P
Besson
Inserm UMR1069 "Nutrition, Croissance et Cancer", Faculté de Médecine, Université François Rabelais de Tours, France.
Virginie
V
Driffort
Inserm UMR1069 "Nutrition, Croissance et Cancer", Faculté de Médecine, Université François Rabelais de Tours, France.
Émeline
É
Bon
Inserm UMR1069 "Nutrition, Croissance et Cancer", Faculté de Médecine, Université François Rabelais de Tours, France.
Frédéric
F
Gradek
Inserm UMR1069 "Nutrition, Croissance et Cancer", Faculté de Médecine, Université François Rabelais de Tours, France; Faculté de Sciences Pharmaceutiques, Université François Rabelais de Tours, France.
Stéphan
S
Chevalier
Inserm UMR1069 "Nutrition, Croissance et Cancer", Faculté de Médecine, Université François Rabelais de Tours, France; Faculté des Sciences et Techniques, Université François Rabelais de Tours, France.
Sébastien
S
Roger
D054758:A Kinase Anchor Proteins / Q000235:genetics / Q000378:metabolism; D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D002465:Cell Movement; D058851:GPI-Linked Proteins / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008564:Membrane Potentials; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D012964:Sodium / Q000378:metabolism*; D059016:Tumor Microenvironment; D061566:Voltage-Gated Sodium Channels / Q000235:genetics / Q000378:metabolism*
D054758:A Kinase Anchor Proteins; D048868:Adaptor Proteins, Signal Transducing; D058851:GPI-Linked Proteins; D061566:Voltage-Gated Sodium Channels; D012964:Sodium
cancer; invasion; lipid raft; metastasis; migration; voltage-gated sodium channel