Antimicrobial metabolites from endophytic Streptomyces sp. YIM61470.
Six compounds were isolated from Streptomyces sp. YIM61470, and their structures elucidated by spectral analysis as (R)-1-O-(phenylacetyl)glycerol (1), 4',5-dihydroxy-6-(3,3-dimethylallyl)-7-methoxyflavanone (2), (32R,33R,34S) -32,33,34,35-bacteriohopanetetrol (3), MKN-003C (4), cyclo (L-Pro-L-Gly) (5), and cyclo(L-Pro-L-Tyr) (6). Compound 1, an chiral monoacylglycerol, was isolated from a natural source for the first time. Compound 2 was first found in microorganisms, and compound 3, a bacteriohopanoid, was found first in the genus Streptomyces. Compounds 1-6 showed weak anti-microbial activity.
Xueqiong
X
Yanga
Yun
Y
Liu
Shuquan
S
Li
Fangfang
F
Yang
Lixing
L
Zhao
Li
L
Peng
Zhongtao
Z
Ding
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D060026:Endophytes / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D029755:Maytenus / Q000382:microbiology*; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*
D000890:Anti-Infective Agents