Bilateral clear cell sarcoma of the kidney.
Clear cell sarcoma of the kidney (CCSK) accounts for 2-5% of all pediatric renal malignancies, and is known for its propensity to metastasize to bone and other sites. We are reporting two cases with bilateral CCSK that were diagnosed at our institution. One patient initially presented with bilateral renal masses, as well as pulmonary, hepatic and bone metastasis; while other present only with bilateral masses with no evident distant metastasis. Both patients received aggressive neo-adjuvant chemotherapy to decrease tumor size. One patient completed his designated treatment and initially showed complete remission (CR); eventually suffering from relapse. The other patient's tumor progressed during the course of chemotherapy. Both cases manifested brain dissemination at the time of relapse or progression. This emphasizes the importance of staging stratification in CCSK. This also illustrates CCSK's ability to metastasize to bone and other sites including the brain (a primary relapse site in our cases).
Pediatric Oncology Department, Children's Cancer Hospital Egypt 57357, Cairo, Egypt; National Cancer Institute, Cairo University, Cairo, Egypt.
Wael
W
Zekri
Research Department, Children's Cancer Hospital Egypt 57357, Cairo, Egypt; Faculty of Science, Cairo University, Cairo, Egypt.
Dina
D
Yehia
Surgery Department, Children's Cancer Hospital Egypt 57357, Cairo, Egypt; National Cancer Institute, Cairo University, Cairo, Egypt.
Maged M
MM
Elshafie
Radiation Therapy Department, Children's Cancer Hospital Egypt 57357, Cairo, Egypt; National Cancer Institute, Cairo University, Cairo, Egypt.
Mohamed Saad
MS
Zaghloul
Surgical Pathology Department, Children's Cancer Hospital Egypt 57357, Cairo, Egypt.
Naglaa
N
El-Kinaai
Surgical Pathology Department, Children's Cancer Hospital Egypt 57357, Cairo, Egypt; National Cancer Institute, Cairo University, Cairo, Egypt.
Hala
H
Taha
Radiology Department, Children's Cancer Hospital Egypt 57357, Cairo, Egypt; National Cancer Institute, Cairo University, Cairo, Egypt.
Amal
A
Refaat
Surgery Department, Children's Cancer Hospital Egypt 57357, Cairo, Egypt; National Cancer Institute, Cairo University, Cairo, Egypt.
Alaa A
AA
Younes
Research Department, Children's Cancer Hospital Egypt 57357, Cairo, Egypt; Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address: ahmadsfar@gmail.com.
Ahmad Samir
AS
Alfaar
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary; D002675:Child, Preschool; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D009392:Nephrectomy; D018227:Sarcoma, Clear Cell / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
Childhood cancers; Clear cell sarcoma; Renal Cancers