Association of Leu125Val polymorphisms in the PECAM-1 gene with the risk of coronary heartdisease: a meta-analysis.
OBJECTIVE
Several published literatures investigated the relation between a polymorphism (Leul25Val) in platelet endothelial cell adhesion molecule-1 (PECAM-1) gene and risk of coronary heart disease (CHD) and did not reach the same conclusion. To shed light on these inconclusive findings, we performed a meta-analysis of studies relating the PECAM-1 genetic polymorphism (Leul25Val) to the risk of CHD.


METHODS
We identified literatures by searching PubMed, EMBASE, Chinese National Knowledge Infrastructure databases (CNKI) and Wanfang database in China. Data from eligible studies were extracted for meta-analysis. CHD risk associated with PECAM-1 genetic polymorphism (Leul25Val) was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). The software Review Manager (Version 5.2) was used for meta-analysis. Publication bias was tested by funnel plot.


RESULTS
A total of 15 studies comprising 3696 cases and 3940 controls fulfilled the inclusion criteria. Our results did not show that Leul25Val polymorphism in PECAM-1 gene was associated with the risk of CHD [(LL+LV) vs VV, OR = 1.15, 95% CI: 0.84-1.56, P = 0.38; (VV+LV) vs LL, OR = 0.96, 95% CI: 0.79-1.17, P = 0.69; V vs L, OR = 1.08, 95% CI: 0.92-1.27, P = 0.80, respectively] by a meta-analysis.


CONCLUSIONS
The results of our meta-analysis suggested that Leul25Val polymorphism in PECAM-1 gene is not a susceptibility marker of CHD.
Department of Cardiac Surgery, Shandong Provincial Hospital Affiliated to Shandong University 324 Jing Wu Wei Qi Road, Jinan 250021, China ; Department of Cardiovascular Surgery, The Central Hospital of Tai'an 29 Long Tan Road, Tai'an 271000, China.
Tao
T
Xia
Department of Ultrasound Branch, The Central Hospital of Tai'an 29 Long Tan Road, Tai'an 271000, China.
Xin
X
Liu
Department of Cardiovascular Surgery, The Central Hospital of Tai'an 29 Long Tan Road, Tai'an 271000, China.
Chang Jiang
CJ
Du
Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University 324 Jing Wu Wei Qi Road, Jinan 250021, China.
Xin
X
Jin
Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University 324 Jing Wu Wei Qi Road, Jinan 250021, China.
Xiang Qian
XQ
Kong
Department of Cardiovascular Surgery, The Central Hospital of Tai'an 29 Long Tan Road, Tai'an 271000, China ; Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University 324 Jing Wu Wei Qi Road, Jinan 250021, China.
Gang
G
Li
PECAM-1; coronary heart disease; polymorphism