Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women.
Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although toll-like receptors (TLRs), that are central to innate immune responses, may be important. We evaluated associations between TLR SNPs and BV among HIV-1 infected and uninfected African women. Logistic regression was used to assess associations between SNPs (N=99) in TLRs 2-4, 7-9 and BV (as classified by Nugent's criteria). Among HIV-1 uninfected women, TLR7 rs5743737 and TLR7 rs1634323 were associated with a decreased risk of BV, whereas TLR7 rs179012 was associated with an increased risk. TLR2 SNP rs3804099 was associated with a decreased risk of BV among HIV-1 infected women. Our findings indicate that there may be differences in TLR association with BV among HIV-1 infected and HIV-1 uninfected women.
Department of Global Health, University of Washington.
Romel D
RD
Mackelprang
Department of Global Health, University of Washington.
Caitlin Wright
CW
Scoville
Department of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco; Bixby Center for Global Reproductive Health.
Craig R
CR
Cohen
Kenya Medical Research Institute (KEMRI), Nairobi, Kenya; Masinde Muliro University of Science and Technology (MMUST), Kakamega, Kenya; Consortium for National Health Research (CNHR), Nairobi, Kenya.
Raphael Omusebe
RO
Ondondo
Department of Anthropology, The University of Michigan.
Abigail W
AW
Bigham
Department of Global Health & Medicine, University of Washington.
Connie
C
Celum
Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington.
Mary S
MS
Campbell
Department of Immunology & Infectious Diseases, Harvard TH Chan School of Public Health.
Max
M
Essex
Department of Medicine, Laboratory Medicine and Epidemiology, University of Washington; Member, Fred Hutchinson Cancer Research Center.
Anna
A
Wald
Department of Obstetrics and Gynecology, University of Nairobi.
James
J
Kiarie
Departments of Medical Microbiology and Internal Medicine, University of Manitoba.
Allan
A
Ronald
Perinatal HIV Research Unit.
Glenda
G
Gray
Department of Global Health & Medicine, University of Washington 325 Ninth Ave, Seattle, WA 98104.
Jairam R
JR
Lingappa
D017088:AIDS-Related Opportunistic Infections / Q000235:genetics*; D000328:Adult; D000349:Africa; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D051193:Toll-Like Receptors / Q000235:genetics*; D016585:Vaginosis, Bacterial / Q000235:genetics*
D051193:Toll-Like Receptors