Using α radiation to boost cancer immunity?
Radioimmunotherapy aims to deliver radiation directly to cancer cells by means of a tumor specific vector coupled to a radionuclide. Alpha radionuclides are very potent agents to treat disseminated cancer and metastasis. We have demonstrated that α radiation can also induce immunogenic cell death, reinforcing interest in their clinical development.
INSERM UMR 892 - CRCNA ; Nantes, France ; University of Nantes ; Nantes, France ; CNRS UMR 6299 ; Nantes, France.
Jean-Baptiste
JB
Gorin
INSERM UMR 892 - CRCNA ; Nantes, France ; University of Nantes ; Nantes, France ; CNRS UMR 6299 ; Nantes, France.
Yannick
Y
Guilloux
Institute for Transuranium Elements ; Karlsruhe, Germany.
Alfred
A
Morgenstern
INSERM UMR 892 - CRCNA ; Nantes, France ; University of Nantes ; Nantes, France ; CNRS UMR 6299 ; Nantes, France ; Institut de Cancérologie de l'Ouest ; Saint-Herblain, France.
Michel
M
Chérel
INSERM UMR 892 - CRCNA ; Nantes, France ; University of Nantes ; Nantes, France ; CNRS UMR 6299 ; Nantes, France.
François
F
Davodeau
INSERM UMR 892 - CRCNA ; Nantes, France ; University of Nantes ; Nantes, France ; CNRS UMR 6299 ; Nantes, France.
Joëlle
J
Gaschet
213Bi, bismuth-213; 224Ra, radium-224; DAMPs, danger associated molecular patterns; DC, dendritic cells; HMGB1, high mobility group box 1; Hsp70, 70 kilodalton heat shock protein; RIT; RIT, radioimmunotherapy; abscopal effect; cancer; immunogenic cell death; ionizing radiation; α emitters