Plasma cell leukemia: Clinicopathologic, immunophenotypic and cytogenetic characteristics of 4 cases.
Plasma cell leukemia (PCL) is a rare hematologic malignancy with very poor outcome. It is defined by the presence of >2 × 10(9)/L plasma cells or >20% plasmacytosis of the differential white cell count in the peripheral blood. Primary PCL is first diagnosed in the leukemic phase, while secondary PCL corresponds to the leukemic transformation of a previously diagnosed multiple myeloma (MM). The incidence of PCL ranges between 2-4% of patients with MM and 0.9% of patients with acute leukemia. In this case series, we describe the clinicopathologic, immunophenotypic, and cytogenetic findings of four patients diagnosed with PCL within a ten-year period (2002-2012) at King Faisal Specialist Hospital and Research Centre (General Organization), Riyadh, Saudi Arabia.
Pathology Department, College of Medicine, Qassim University, Buraidah, Saudi Arabia. Electronic address: nahlah.sg@gmail.com.
Nahlah
N
Alghasham
Departments of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address: nounou@kfshrc.edu.sa.
Randa
R
Alnounou
King Faisal Cancer Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address: halzahrani@kfshrc.edu.sa.
Hazzaa
H
Alzahrani
King Faisal Cancer Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address: alshraif@kfshrc.edu.sa.
Fahad
F
Alsharif
D000368:Aged; D020732:Cytogenetic Analysis; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D016130:Immunophenotyping; D007952:Leukemia, Plasma Cell / Q000453:epidemiology / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D012529:Saudi Arabia / Q000453:epidemiology
Leukemia; Multiple myeloma; Plasma cell; Plasma cell leukemia