[The treatment of locally recurrent rectal cancer].
Its incidence has decreased in recent decades due to advances in the treatment of patients with primary rectal cancer, but LRRC still occurs in 6-10% of these patients. LRRC is often accompanied by severe, progressive pain and has a major impact on quality of life. Curative treatment is possible based on surgical resection combined with chemoradiotherapy. Radical resection is the most important prognostic factor in curative treatment. Neo-adjuvant systemic therapy may further improve outcomes in LRRC patients. Many patients are not eligible for surgical treatment due to the presence of metastases or irresectability of the local recurrence. These patients should receive optimal palliative care for the disabling pain. Radiotherapy is effective against local pain in around 75% of patients but the duration of palliation is limited.
Erasmus MC Kanker Instituut, Rotterdam.
Wijnand J
WJ
Alberda
Cornelis
C
Verhoef
Joost J
JJ
Nuyttens
Joost
J
Rothbarth
Jacobus W A
JW
Burger
D003131:Combined Modality Therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D059408:Pain Management; D010166:Palliative Care; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*