Trazodone induced galactorrhea: a case report.
Trazodone is a heterocyclic antidepressant that exerts its effect via the inhibition of selective serotonin reuptake and the antagonism of 5-HT2A and 5-HT2C receptors. Antidepressant-induced galactorrhea and increases in prolactin levels have rarely been reported. Trazodone can potentiate the serotonergic activity of citalopram. To our knowledge, no cases of galactorrhea associated with use of trazodone have been reported to date. This report describes a unique case of the development of galactorrhea following the addition of trazodone (100 mg/day, 2 weeks) to the treatment of a patient who was receiving citalopram (40 mg/day, 6 weeks) therapy for a diagnosis of depressive disorder, which improved upon the discontinuation of trazodone.
Department of Psychiatry, Karadeniz Technical University School of Medicine, Trabzon 61080, Turkey. Electronic address: filiz_civil@yahoo.com.
Filiz Civil
FC
Arslan
Department of Psychiatry, Karadeniz Technical University School of Medicine, Trabzon 61080, Turkey.
Emel Korkmaz
EK
Uysal
Department of Psychiatry, Karadeniz Technical University School of Medicine, Trabzon 61080, Turkey.
Evrim
E
Ozkorumak
Department of Psychiatry, Karadeniz Technical University School of Medicine, Trabzon 61080, Turkey.
Ahmet
A
Tiryaki
D015283:Citalopram / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005687:Galactorrhea / Q000139:chemically induced*; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D014196:Trazodone / Q000009:adverse effects*; D055815:Young Adult
D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone
Citalopram; Galactorrhea; Prolactin; Trazodone