Seroreactivity against Merkel cell polyomavirus and other polyomaviruses in chronic lymphocytic leukaemia, the MCC-Spain study.
Merkel cell polyomavirus (MCPyV) has been suspected to cause chronic lymphocytic leukaemia (CLL) but previous data are inconsistent. We measured seroreactivities of nine polyomaviruses (MCPyV, BKPyV, JCPyV, LPyV, KIPyV, WUPyV, HPyV-6, HPyV-7 and TSPyV) in 359 CLL cases and 370 controls using bead-based multiplex serology technology. We additionally tested two herpesviruses (HSV-1 and CMV). Associations between disease and viral seroreactivities were assessed using logistic regression. All human viruses showed high seroprevalences (69-99%) against structural proteins in controls but significantly lower viral seroprevalences in cases (58-94%; OR range = 0.21-0.70, P value < 0.05), except for MCPyV (OR = 0.79, 95% CI = 0.54-1.16). Lower seroreactivity levels were observed among CLL subjects, with significant differences already observed at early stages of disease, unrelated to treatment status. Seroreactivities against polyomavirus related oncoproteins were almost null. Our data suggest no association for MCPyV polyomavirus with CLL development and an unlikely association for other polyomaviruses tested.
Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.|Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia - Catalan Institute of Oncology, IDIBELL, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.
Claudia
C
Robles
Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia - Catalan Institute of Oncology, IDIBELL, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.
Delphine
D
Casabonne
Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia - Catalan Institute of Oncology, IDIBELL, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.
Yolanda
Y
Benavente
Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia - Catalan Institute of Oncology, IDIBELL, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.
Laura
L
Costas
Hematology Department, Institut Catala d'Oncologia - Catalan Institute of Oncology, , IDIBELL, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.
Eva
E
Gonzalez-Barca
Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, 08036 Barcelona, Spain.
Marta
M
Aymerich
Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, 08036 Barcelona, Spain.
Elias
E
Campo
CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.|Instituto Universitario de Oncología, University of Oviedo, 33006 Oviedo, Spain.
Adonina
A
Tardon
CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.|Department of Preventive Medicine and Public Health, University of Granada, 18071 Granada, Spain.|Instituto de Investigación Biosanitaria de Granada, Servicio Andaluz de Salud/Universidad de Granada, 18012 Granada, Spain.
José J
JJ
Jiménez-Moleón
Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.|IMIM (Hospital del Mar Research Institute), 08003 Barcelona, Spain.|Centre for Research in Environmental Epidemiology (CREAL), 08003 Barcelona, Spain.
Gemma
G
Castaño-Vinyals
CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.|Facultad de Medicina, Universidad de Cantabria - IDIVAL, 39011 Santander, Spain.
Trinidad
T
Dierssen-Sotos
Infections and Cancer Epidemiology, Infection and Cancer Program, German Cancer Research Center (DKFZ), , 69121 Heidelberg, Germany.
Angelika
A
Michel
Department of Genome Modifications and Carcinogenesis, Infection and Cancer Program, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Lena
L
Kranz
CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.|Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.|IIS Puerta de Hierro, 28222 Majadahonda, Spain.
Nuria
N
Aragonés
CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.|Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, 28029 Madrid, Spain.|IIS Puerta de Hierro, 28222 Majadahonda, Spain.
Marina
M
Pollan
National School of Public Health, Athens AL 35611, Greece.|CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.|IMIM (Hospital del Mar Research Institute), 08003 Barcelona, Spain.|Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.|Centre for Research in Environmental Epidemiology (CREAL), 08003 Barcelona, Spain.
Manolis
M
Kogevinas
Department of Genome Modifications and Carcinogenesis, Infection and Cancer Program, German Cancer Research Center (DKFZ), 69121 Heidelberg, Germany.
Michael
M
Pawlita
Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia - Catalan Institute of Oncology, IDIBELL, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.|CIBER Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.
Silvia
S
de Sanjose
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D008297:Male; D059965:Merkel cell polyomavirus / Q000235:genetics / Q000276:immunology*; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D016036:Seroepidemiologic Studies; D013030:Spain / Q000453:epidemiology; D014412:Tumor Virus Infections / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000821:virology
D000914:Antibodies, Viral