Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer.
In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.
Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India ; National Cancer Institute, NIH, Bethesda, MD, USA 20892.
Alok
A
Mishra
Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India ; Mayo Clinic, Rochester, MN, USA 55905 ; Rakesh Kumar deceased.
Rakesh
R
Kumar
Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India.
Abhishek
A
Tyagi
Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; National Cancer Institute, NIH, Bethesda, MD, USA 20892.
Indu
I
Kohaar
Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India.
Suresh
S
Hedau
Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India.
Alok C
AC
Bharti
Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India.
Subhodeep
S
Sarker
Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India.
Dipankar
D
Dey
Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India.
Daman
D
Saluja
Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India ; Amity University, Noida 201303, India.
Bhudev
B
Das
activator protein-1 (AP-1); curcumin; human papilloma virus (HPA); nuclear factor kappaB (NF-kB); transcription