Effect of Administration of Single Dose GnRH Agonist in Luteal Phase on Outcome of ICSI-ET Cycles in Women with Previous History of IVF/ICSI Failure: A Randomized Controlled Trial.
BACKGROUND
GnRH agonist administration in the luteal phase has been suggested to beneficially affect the outcome of intracytoplasmic sperm injection (ICSI) and embryo transfer (ET) cycles. This blind randomized controlled study evaluates the effect of GnRH (Gonadotropine Releasing Hormone) agonist administration on ICSI outcome in GnRH antagonist ovarian stimulation protocol in women with 2 or more previous IVF/ICSI-ET failures.


METHODS
One hundred IVF failure women who underwent ICSI cycles and stimulated with GnRH antagonist ovarian stimulation protocol, were included in the study. Women were randomly assigned to intervention (received a single dose injection of GnRH agonist (0.1 mg of Decapeptil) subcutaneously 6 days after oocyte retrieval) and control (did not receive GnRH agonist) groups. Implantation and clinical pregnancy rates were the primary outcome measures.


RESULTS
Although the age of women, the number of embryos transferred in the current cycle and the quality of the transferred embryos were similar in the two groups, there was a significantly higher rate of implantation (Mann Whitney test, p = 0.041) and pregnancy (32.6% vs. 12.5%, p = 0.030, OR = 3.3, 95%CI, 1.08 to 10.4) in the intervention group.


CONCLUSIONS
Our results suggested that, in addition to routine luteal phase support using progesterone, administration of 0.1 mg of Decapeptil 6 days after oocyte retrieval in women with previous history of 2 or more IVF/ICSI failures led to a significant improvement in implantation and pregnancy rates after ICSI following ovarian stimulation with GnRH antagonist protocol.
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Simin
S
Zafardoust
Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Mahmood
M
Jeddi-Tehrani
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Mohammad Mehdi
MM
Akhondi
Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Mohammad Reza
MR
Sadeghi
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Koroush
K
Kamali
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Sara
S
Mokhtar
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Bita
B
Badehnoosh
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Fatemeh
F
Arjmand-Teymouri
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Farnaz
F
Fatemi
Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran.
Afsaneh
A
Mohammadzadeh
Decapeptil; GnRH agonist; GnRH antagonist; ICSI; IVF failure; Implantation failure; Intracytoplasmic sperm injection; Luteal phase support