Minocycline-loaded cellulose nano whiskers/poly(sodium acrylate) composite hydrogel films as wound dressing.
In this work, antibiotic drug Minocycline (Mic) loaded cellulose nano-whiskers (CNWs)/poly(sodium acrylate) hydrogel films were prepared and investigated for their drug releasing capacity in physiological buffer solution (PBS) at 37 °C. The (CNWs)/poly(sodium acrylate) film, containing 9.7% (w/w) of CNWs, demonstrated Mic release of 2500 μg/g while the plain poly(acrylate) film showed 3100 μg/g of drug release. In addition, with the increase in the concentration of cross-linker N,N'-methylene bisacrylamide (MB) from to, the drug release from the resulting films decreased from 507 to 191 μg/g. The release exponent 'n' for films with different compositions was found in the range of 0.45 to 0.89, thus indicating non-Fickian release mechanism. The Schott model was employed to interpret the kinetic drug release data successfully. The film samples poly(SA) and CNWs/poly(SA) (both not containing drug) showed thrombus formation of 0.010±0.001 g and 0.007±0.001 g, respectively, thus showing the non-thrombogenic behavior. In percent Hemolysis, both of the film samples of 1.136±0.012 and 0.5±0.020, respectively, thus indicating non-hemolytic behavior. In addition, both of the film samples demonstrated protein adsorption of 49.02±0.59μ g/μL and 51.20±0.51 μg/μL per cm(2), thus revealing a fair degree of protein adsorption. Finally, the Mic-loaded films showed fair anti-fungal and antibacterial properties.
Polymer Research Laboratory, Department of Chemistry, Govt. Model Science College, Jabalpur 482001, MP, India. Electronic address: sunil.mnlbpi@gmail.com.
S K
SK
Bajpai
Department of Physical Science, Mahatma Gandhi Gramodaya University, Chitrakoot, MP, India.
V
V
Pathak
Polymer Research Laboratory, Department of Chemistry, Govt. Model Science College, Jabalpur 482001, MP, India. Electronic address: bhavnasoni149@gmail.com.
Bhawna
B
Soni
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects / Q000254:growth & development; D001458:Bandages; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology*; D049329:Nanostructures / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D020100:Hydrogels; D002482:Cellulose; D008911:Minocycline
Blood compatibility test; Cellulose nano whiskers; Drug release; Hydrogel film; Wound dressing