Preliminary comparison of diffusion-weighted MRI and PET/CT in predicting histological type and malignancy of lung cancer.
BACKGROUND
Emerging evidence shows that diffusion-weighted magnetic resonance imaging (DW MRI) and fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) might be useful in predicting histological type and malignancy of lung cancer, and even in specifically detecting the types of gene mutation.


OBJECTIVE
We assessed whether DW MRI is equivalent to PET/CT in lung cancer diagnosis and evaluation.


METHODS
The institutional review board approved this study, and written informed consent was obtained from all patients. DW MRI and FDG PET/CT were performed before therapy in 15 lung cancer patients diagnosed by pathological examination. Apparent diffusion coefficient (ADC), ratio of ADC (rADC = ADC in tumor/ADC in spinal cord) and maximal standardized uptake value (SUVmax) were assessed.


RESULTS
ADC, rADC and SUVmaxdid not reveal significant differences among different types of lung cancer. Sensitivity, specificity and accuracy of ADC, rADC and SUVmaxproved to be not significantly different in the detection of adenocarcinoma and squamous cell carcinoma. Difference in the abilities of the sensitivity, specificity and accuracy of ADC, rADC and SUVmaxto detect adenocarcinoma and squamous cell carcinoma proved to be insignificant. Although Ki-67 score did not show correlation with ADC, rADC and SUVmax, significant positive correlation was found between ADC and rADC, and ADC and SUVmax.


CONCLUSIONS
Both DW MRI and FDG PET/CT had similar limited diagnostic capability of predicting different histological types and malignancy of lung cancer. This study may help provide a novel insight into diagnostic and therapeutic strategies of lung cancer based on DW MRI.
Thoracic Cancer Center, Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Li-Peng
LP
Liu
Thoracic Cancer Center, Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Xin-Xin
XX
Zhang
Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Long-Biao
LB
Cui
Thoracic Cancer Center, Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Jie
J
Li
Thoracic Cancer Center, Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Juan-Li
JL
Yang
Thoracic Cancer Center, Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Hai-Nan
HN
Yang
Thoracic Cancer Center, Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Yan
Y
Zhang
Thoracic Cancer Center, Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Ying
Y
Zhou
Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Xing
X
Tang
Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Shun
S
Qi
Thoracic Cancer Center, Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Yuan
Y
Fang
Thoracic Cancer Center, Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Jian
J
Zhang
Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Hong
H
Yin
D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009154:Mutation; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals / Q000494:pharmacology
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
adenocarcinoma; diffusion-weighted magnetic resonance imaging; fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography; lung cancer; squamous cell carcinoma