Paraneoplastic autoimmune hemolytic anemia in ovarian cancer: a marker of disease activity.
Autoimmune hemolytic anemia (AIHA) is a rare paraneoplastic syndrome associated with ovarian malignancies. We report a case of a 77 year-old female with metastatic ovarian carcinoma who presented with worsening anemia from her baseline, and was found to have a warm autoimmune hemolytic anemia. We performed a literature review and analyzed all 10 cases (including our patient) that have been reported to date, and incorporated the clinical presentation, histology and stage of underlying malignancies, types, treatment, prognosis and mechanisms of AIHA in ovarian carcinoma.
Division of General Medicine, Baystate Medical Center/Tufts University School of Medicine , Springfield, MA, USA.
Kah Poh
KP
Loh
Division of Hematology/Oncology, Department of Medicine, Baystate Medical Center/Tufts University School of Medicine , Springfield, MA, USA.
Ankit
A
Kansagra
Division of Hematology/Oncology, Department of Medicine, Baystate Medical Center/Tufts University School of Medicine , Springfield, MA, USA.
Armen
A
Asik
Division of Hematology/Oncology, Department of Medicine, Baystate Medical Center/Tufts University School of Medicine , Springfield, MA, USA.
Syed
S
Ali
Division of Hematology/Oncology, Department of Medicine, Baystate Medical Center/Tufts University School of Medicine , Springfield, MA, USA.
Saurabh
S
Dahiya
autoimmune hemolytic anemia; ovarian cancer; paraneoplastic syndrome