Cushing's disease: towards precision medicine.
The pathogenesis of Cushing's disease is poorly understood; two recent reports identifying somatic mutations in USP8 in pituitary corticotroph tumors provide exciting advances in this field. These mutations alter EGFR trafficking and signaling, raising the prospect that EGFR inhibitors may move the treatment of this disease into the era of precision medicine.
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA.
Ursula B
UB
Kaiser
D049913:ACTH-Secreting Pituitary Adenoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D010450:Endopeptidases / Q000235:genetics; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics; D006801:Humans; D009154:Mutation; D047748:Pituitary ACTH Hypersecretion / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D057285:Precision Medicine; D015398:Signal Transduction / Q000187:drug effects; D043222:Ubiquitin Thiolesterase / Q000235:genetics
D056827:Endosomal Sorting Complexes Required for Transport; D066246:ErbB Receptors; D010450:Endopeptidases; C541534:USP8 protein, human; D043222:Ubiquitin Thiolesterase