Selection of chemotherapy for hyperthermic intraperitoneal use in gastric cancer.
OBJECTIVE
Several studies have shown the potential benefit of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in gastric cancer patients. At present the most effective chemotherapeutic regime in HIPEC for gastric cancer is unknown. The aim of this review was to provide a comprehensive overview of chemotherapeutic agents used for HIPEC in gastric cancer.


METHODS
A literature search was conducted using the PubMed database to identify studies on chemotherapy used for HIPEC in gastric cancer patients.


CONCLUSIONS
The chemotherapeutic regime of choice in HIPEC for gastric cancer has yet to be determined. The wide variety in studies and study parameters, such as chemotherapeutic agents, dosage, patient characteristics, temperature of perfusate, duration of perfusion, carrier solutions, intraperitoneal pressure and open or closed perfusion techniques, warrant more experimental and clinical studies to determine the optimal treatment schedule. A combination of drugs probably results in a more effective treatment.
Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands. Electronic address: H.Braam@antoniusziekenhuis.nl.
H J
HJ
Braam
Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Science Faculty, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
J H
JH
Schellens
Division of Gastroenterology and Hepatology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
H
H
Boot
Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
J W
JW
van Sandick
Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.
C A
CA
Knibbe
Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
D
D
Boerma
Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.
B
B
van Ramshorst
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D010478:Chemotherapy, Cancer, Regional Perfusion; D006801:Humans; D006979:Hyperthermia, Induced; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents
Chemotherapy; Hyperthermia; Intraoperative period; Intraperitoneal; Metastasis; Peritoneal neoplasms; Pharmacokinetics; Stomach neoplasms