Metabolic acidosis in renal transplantation: neglected but of potential clinical relevance.
Chronic metabolic acidosis (CMA) is a common complication of the more advanced stages of chronic kidney diseases (CKD), and is associated with morbidity and mortality of CKD patients and possibly with the progression of renal disease. Nevertheless, there is limited evidence or information on the prevalence, the potential causal factors, the clinical impact and the effects of correction of CMA in kidney transplant recipients. In this review, we briefly look at the more relevant, though scanty, studies which have, over time, addressed the above-mentioned points, with the hope that in the future the interest of transplant nephrologists and surgeons will grow towards this unreasonably neglected issue.
Unit of Nephrology-Dialysis, Urology and Renal Transplantation, IRCCS Fondazione Ca' Granda-Ospedale Maggiore-Policlinico, Milano, Italy.
Pier Giorgio
PG
Messa
Unit of Nephrology-Dialysis, Urology and Renal Transplantation, IRCCS Fondazione Ca' Granda-Ospedale Maggiore-Policlinico, Milano, Italy.
Carlo
C
Alfieri
Unit of Nephrology-Dialysis, Urology and Renal Transplantation, IRCCS Fondazione Ca' Granda-Ospedale Maggiore-Policlinico, Milano, Italy.
Simone
S
Vettoretti
D000138:Acidosis / Q000209:etiology*; D006801:Humans; D007674:Kidney Diseases / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*
allograft dysfunction; metabolic acidosis; renal transplantation