Zn(2+)-Triggered Drug Release from Biocompatible Zirconium MOFs Equipped with Supramolecular Gates.
A new theranostic nanoplatform, comprising of monodisperse zirconium metal-organic frameworks (MOFs) as drug carriers and carboxylatopillar[5]arene-based supramolecular switches as gating entities, is constructed, and controlled drug release triggered by bio-friendly Zn(2+) ions (abundant in synaptic vesicles) and auxiliary thermal stimulus is realized. This on-command drug delivery system exhibits large pore sizes for drug encapsulation, excellent biodegradability and biocompatibility, extremely low cytotoxicity and premature drug release, and superior dual-stimuli responsiveness, opening a new avenue in targeted drug delivery and controlled release of therapeutic agents, especially in the treatment of central nervous system diseases.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
Li-Li
LL
Tan
Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P. R. China.
Haiwei
H
Li
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
Yue
Y
Zhou
Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P. R. China.
Yuanyuan
Y
Zhang
Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P. R. China.
Xiao
X
Feng
Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P. R. China.
Bo
B
Wang
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
Ying-Wei
YW
Yang
D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D007477:Ions; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D009930:Organic Chemicals / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D013499:Surface Properties; D015032:Zinc / Q000032:analysis* / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry*
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D007477:Ions; D009930:Organic Chemicals; D000644:Quaternary Ammonium Compounds; D015040:Zirconium; D015032:Zinc
Zn2+ triggers; drug delivery; metal-organic frameworks; pillarene; supramolecular switches; targeted drug release