Alterations of serum brain type natriuretic peptide (BNP) in patients with Crimean-Congo hemorrhagic fever.
BACKGROUND
Crimean-Congo hemorrhagic fever (CCHF) is known to be associated with cardiac damage. Brain type natriuretic peptide (BNP) is secreted from stressed myocardium.


OBJECTIVE
This study investigated that BNP levels in CCHF and its association with clinical course of disease.


METHODS
Consecutive CCHF diagnosis confirmed patients were enrolled to the study. Results of patients were compared with age-sex-matched healthy volunteers. Blood samples for BNP levels were collected from the patients during emergency room applications. Mortality, hospitalization duration and other disease severity predictors (thrombocyte count, hemoglobin, white blood cell count, alanine aminotransferase, aspartate aminotransferase, prothrombin time, lactate dehydrogenase, international normalized ratio, activated partial thromboplastin time) were recorded. These parameters' correlations with BNP levels were analyzed.


RESULTS
Forty-three CCHF patients and 28 control subjects recruited to the study. Groups were similar for age and gender. There was no mortality. Levels of BNP were found to be significantly higher in patients than control subjects (100.4±45.4 vs. 78.0±40.4, P=0.033). But BNP levels were not correlated with duration of hospitalization and disease severity predictors (P > 0.05).


CONCLUSIONS
This study showed that BNP levels are modestly increased in CCHF but this increase does not correlated with disease severity predictors.
Department of Microbiology, Faculty of Medicine, Cumhuriyet University Sivas, Turkey.
Elif Bilge
EB
Uysal
Department of Biochemistry, Faculty of Medicine, Cumhuriyet University Sivas, Turkey.
Enver
E
Sancakdar
Muhittin Altınok Family Health Center Sivas, Turkey.
Ayşe
A
Şeker
Department of Biochemistry, Faculty of Medicine, Cumhuriyet University Sivas, Turkey.
Köksal
K
Deveci
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Cumhuriyet University Sivas, Turkey.
Nevin
N
Tuzcu
Department of Cardiology, Faculty of Medicine, Cumhuriyet University Sivas, Turkey.
Hekim
H
Karapınar
Crimean-Congo hemorrhagic fever; brain type natriuretic peptide; cardiac damage