Anti-TMV activity flavones from the leaves of Yunnan local air cured tobacco.
Four new flavones, tobaflavones E-H (1-4), together with two known flavones (5 and 6), were isolated from the leaves of Dali Tiandeng tobacco (a variety of Yunnan local air cured tobacco). Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compound 2 is the first naturally occurring flavone bearing a (4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methyl moiety. These compounds were also evaluated for their anti-tobacco mosaic virus (anti-TMV) activity. The results revealed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rate of 35.3% and 39.6%, respectively. The rates are higher than those of positive control. The other compounds also showed potential anti-TMV activity with inhibition rates in the range of 18.7-28.4%, respectively.
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China.
Ming-Ming
MM
Miao
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China; School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, PR China.
Lan
L
Li
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China.
Qin-Peng
QP
Shen
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China.
Chun-Bo
CB
Liu
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China.
Yin-Ke
YK
Li
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China.
Tao
T
Zhang
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China.
Feng-Mei
FM
Zhang
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China.
Pei
P
He
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China.
Kun-Miao
KM
Wang
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China.
Rui-Zhi
RZ
Zhu
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China. Electronic address: cyk1966@163.com.
Yong-Kuan
YK
Chen
Key Laboratory of Tobacco Chemistry of Yunnan Province, China tobacco Yunnan industrial Co., Ltd, Kunming 650231, PR China. Electronic address: ygy1110@163.com.
Guang-Yu
GY
Yang
D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002681:China; D047309:Flavones / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D014026:Nicotiana / Q000737:chemistry*; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
D000998:Antiviral Agents; D047309:Flavones
Air cured tobacco; Anti-tobacco mosaic virus activity; Flavones