The tumour necrosis factor-α 308G>A genetic polymorphism may contribute to the pathogenesis of acne: a meta-analysis.
BACKGROUND
Tumour necrosis factor (TNF)-α is considered to play a central role in the pathogenesis of acne.


OBJECTIVE
To estimate the association between the TNF-α 308G>A polymorphism and the pathogenesis of acne.


METHODS
A literature search of the PubMed and CNKI databases from inception to December 2013 was conducted. Meta-analyses were performed, and the OR and 95% CI calculated. The strength of association was assessed under five genetic models: allele (A vs. G), dominant (AA+AG vs. GG), recessive (AA vs. GG+AG), homozygous (AA vs. GG), and heterozygous (AA vs. AG).


RESULTS
Seven case-control studies were included, with a total of 987 patients with acne and 1078 healthy controls. The meta-analysis result showed a significant association between TNF-α 308G>A and the pathogenesis of acne under the recessive (OR = 3.13, 95% CI 1.67-5.86, P < 0.001), homozygous (OR = 3.03, 95% CI 1.63-5.63, P < 0.001) and heterozygous (OR = 3.16, 95% CI 1.61-6.20, P < 0.001) models. The subgroup analysis showed a significant association with male sex (recessive: OR = 3.77, 95% CI 1.26-11.25, P = 0.02, homozygous: OR = 3.25, 95% CI 1.03-10.22, P = 0.04) and severe acne (recessive: OR = 4.62, 95% CI 1.73-12.34, P < 0.01; homozygous: OR = 3.41, 95% CI 1.18-9.89, P = 0.02).


CONCLUSIONS
Our findings indicate that genotype AA of TNF-α 308G>A may contribute to the pathogenesis of acne. Thus, detection of the TNF-α 308G>A polymorphism may be a promising biomarker for the early detection of acne.
Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
L
L
Li
Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
Y
Y
Wu
Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
L
L
Li
Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
Y F
YF
Cai
Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
L
L
Geng
Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
X H
XH
Gao
Department of Dermatology, First Hospital of China Medical University, Shenyang, China.
H D
HD
Chen
D000152:Acne Vulgaris / Q000235:genetics*; D000483:Alleles; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha