Poor Prognosis in Critical Limb Ischemia Without Pre-Onset Intermittent Claudication.
BACKGROUND
Some patients with critical limb ischemia (CLI) lack symptoms of intermittent claudication (IC) before the onset of CLI. We studied the outcome of such patients, because this is currently unknown. METHODS AND RESULTS: For retrospective exploratory analysis, we divided 225 patients (265 limbs) with CLI into 2 groups: 142 patients (172 limbs) without a history of IC (non-IC group) and 83 patients (93 limbs) with IC (IC group). We examined comorbid factors and found that a higher proportion of patients in the non-IC group failed to undergo arterial revascularization (49% vs. 20%, P<0.0001) due to progressed limb ischemia and infection. We then analyzed 140 patients (161 limbs) with revascularization. Patients in the non-IC group were more likely to have diabetes mellitus (P=0.03), hypoalbuminemia (P=0.02), advanced Rutherford's classification (P=0.0007), worse ambulatory function (P=0.009), and longer postoperative stay (P=0.04). Amputation-free survival was lower in the non-IC group (P=0.005). On Cox regression analysis, hemodialysis (P=0.002), coronary artery disease (P=0.04), cerebrovascular disease (P=0.02), non-ambulatory status (P=0.02), and non-IC (P=0.01) were independent risk factors for lower amputation-free survival.


CONCLUSIONS
Patients without IC before CLI onset have several unique features, and non-IC is an independent risk factor for poor outcome.
Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
Takuro
T
Shirasu
Katsuyuki
K
Hoshina
Satoshi
S
Yamamoto
Kunihiro
K
Shigematsu
Tetsuro
T
Miyata
Toshiaki
T
Watanabe
D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000601:surgery; D048909:Diabetes Complications / Q000175:diagnosis / Q000601:surgery; D005121:Extremities / Q000098:blood supply / Q000601:surgery; D005260:Female; D006801:Humans; D034141:Hypoalbuminemia / Q000175:diagnosis / Q000601:surgery; D007383:Intermittent Claudication / Q000175:diagnosis / Q000601:surgery; D007511:Ischemia / Q000175:diagnosis / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014656:Vascular Surgical Procedures