A novel HLA-A allele, HLA-A*02:544.
The novel allele HLA-A*02:544 has two nucleotide changes from its most closely related allele, HLA-A*02:148. Firstly at nucleotide 255 where C → T (codon 60 GAC → GAT), resulting in a non-coding change as GAC and GAT both code for the same amino acid aspartic acid. Secondly at nucleotide 368 where T → G (codon 98 TTT → TGT) resulting in a coding change, 98 phenylalanine is changed to cysteine.
Department of Obstetrics and Gynecology, Peking University, Third Hospital, Beijing, PR China.
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X
Zhu
T
T
Yang
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Tan
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Su
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Z
Luo
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Zhen
D000328:Adult; D000483:Alleles; D001483:Base Sequence; D001853:Bone Marrow; D002681:China; D005805:Genes, MHC Class I; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D014019:Tissue Donors
D015234:HLA-A Antigens
human leukocyte antigen A*02:544; novel allele; polymerase chain reaction sequence-based typing