Clinical correlates of superior temporal gyrus volume abnormalities in antipsychotic-naïve schizophrenia.
In this study, the authors report superior temporal gyrus (STG) and Heschl's gyrus (HG) volume deficits in a large sample of medication-naïve patients with schizophrenia (N=55) in comparison with healthy control subjects (N=45) with structural MRI using voxel-based morphometry. Patients had significantly smaller volumes of left HG [X=-41, Y=-22, Z=11; Brodmann's area (BA)-41), right HG (X=47, Y=-18, Z=11; BA-41), and left STG (X=-50, Y=-34, Z=11; BA-42] compared with healthy control subjects. In addition, Positive and Negative Syndrome Scale positive score had a significant negative correlation with left HG. Findings observed in a large sample of antipsychotic-naive patients with schizophrenia emphasize the role of HG and STG in the pathophysiology of schizophrenia.
From the Schizophrenia Clinic, Dept. of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India (JCN, SVK, GV, BNG); and the Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, India (JCN, SVK, GV).
Janardhanan C
JC
Narayanaswamy
Sunil V
SV
Kalmady
Ganesan
G
Venkatasubramanian
Bangalore N
BN
Gangadhar
D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology*; D055815:Young Adult