Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla.
One new benzofuran, (2R)-(2',4'-dihydroxybenzyl)-6,7-methylenedioxy-2,3-dihydrobenzofuran (1), one new phenylisocoumarin, 3-(2'-hydroxyphenyl)-6,8-dihydroxy-7-methoxy-isocoumarin (2), and one new benzofuroisocoumarin, platyphyllarin C (3), were isolated from the ethanolic extract of Liriope platyphylla aerial parts, along with seventeen known compounds. The structures of the isolates were established by spectroscopic analysis and comparison with the literature data. The results indicated that structures 1-3 are uncommon in Nature. Benzofuroisocoumarin 4, flavonoids 9, 10, and 13-15, and homoisoflavonoids 19 and 20 exhibited significant binding activity to estrogen-receptor α and/or β as demonstrated by the SEAP reporter assay system in an MCF-7 cell-line.
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yuchi0713@gmail.com.
Yu-Chi
YC
Tsai
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. chia6494@yahoo.com.tw.|Department of Laboratory Medicine, Paochien Care Cooperation Paochien Hospital, Pingtung 900, Taiwan. chia6494@yahoo.com.tw.
Chia-Chun
CC
Hsu
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. elshazly444@googlemail.com.|Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt. elshazly444@googlemail.com.
Mohamed
M
El-Shazly
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. rhytlise@gmail.com.
Shang-Yu
SY
Chiang
Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. chauchungwu@ntu.edu.tw.
Chau-Chung
CC
Wu
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. ccwu@kmu.edu.tw.
Chin-Chung
CC
Wu
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. stellapple7@gmail.com.
Wan-Chun
WC
Lai
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yen@kmu.edu.tw.
Ming-Hong
MH
Yen
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
Yang-Chang
YC
Wu
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.|Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.|Research Center for Natural Product and New Drug, Kaohsiung Medical University, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.|Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.
Fang-Rong
FR
Chang
D002839:Chromans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D047628:Estrogen Receptor alpha / Q000378:metabolism; D047629:Estrogen Receptor beta / Q000378:metabolism; D004967:Estrogens / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031424:Liriope Plant / Q000737:chemistry*; D061986:MCF-7 Cells; D015394:Molecular Structure; D064209:Phytochemicals / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*
D002839:Chromans; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D004967:Estrogens; D049934:Isocoumarins; D064209:Phytochemicals; D010936:Plant Extracts