Primary Cutaneous T-cell Lymphoma With Aberrant CD-20 Expression.
OBJECTIVE
Primary cutaneous T-cell lymphoma with aberrant expression of cluster of differentiation (CD) 20 is an exceedingly rare manifestation of cutaneous T-cell lymphoma that is easily misdiagnosed as B-cell lymphoma. The significance and prognostic implications of T-cell neoplasms demonstrating the classic CD20 B-cell marker have yet to be elucidated.


METHODS
We present a case of primary cutaneous T-cell lymphoma with aberrant CD20 expression in a 97-year-old male who presented with a 2-year history of pruritic plaques and nodules covering his body. Nodule biopsy demonstrated a dense, atypical dermal T-lymphocytic infiltrate consisting of predominantly large cells exhibiting classic T-cell markers (CD4 and CD3) along with aberrant expression of the B-cell marker CD20 (expressed in late pro-B to mature B cells).


CONCLUSIONS
The patient was tentatively diagnosed with primary cutaneous CD30-negative large T-cell lymphoma with aberrant CD20 co-expression, pending workup to exclude systemic lymphoma with cutaneous involvement. He unfortunately passed away 4 days after the initial dermatologic presentation.


CONCLUSIONS
The prognostic implications of CD20-positive T-cell lymphoma require further exploration, along with the potential role of CD20 antibody in treatment of this rare malignancy.
Chante
C
Karimkhani
Cristina
C
McLaughlin
Christopher
C
Smith
D000369:Aged, 80 and over; D018951:Antigens, CD20 / Q000235:genetics*; D001402:B-Lymphocytes / Q000378:metabolism; D001706:Biopsy; D017809:Fatal Outcome; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D008297:Male; D011379:Prognosis; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*
D018951:Antigens, CD20