Long term ingestion of a preload containing fructo-oligosaccharide or guar gum decreases fat mass but not food intake in mice.
Fermentable dietary fibre such as fructo-oligosaccharide and viscous dietary fibers such as guar gum and alginate affect energy homeostasis. The goal of this study was to compare the impact of long term intake of these three dietary fibers on food intake, meal pattern, body weight and fat accumulation in mice. Over a period of 3weeks, the mice were fed daily with a preload containing 32mg of fructo-oligosaccharide or alginate or 13mg of guar gum. Food intake and body weight were monitored weekly, while meal patterns, adiposity and the expression of hypothalamic neuropeptide genes were evaluated at the end of the study period. The 3 dietary fibers produced a similar decrease in total daily food intake (14 to 22%) at the end of the first week, and this effect disappeared over time. The 3 dietary fibers induced a slight variation in satiation parameters. Body weight and expression of hypothalamic neuropeptide genes were not affected by any of the treatment. Preload of fructo-oligosaccharide and guar gum induced a similar and substantial decrease in the development of adiposity (17% and 14%, respectively), while alginate had no effect. Our results demonstrate mainly that the inhibitory effect of dietary fiber on food intake is lost over time, and that guar gum limits fat storage.
Laboratoire de Bioressources Naturelles Locales, Département de Biologie, Faculté des Sciences, Université Hassiba Ben Bouali, Chlef, Algeria.
Zouheyr
Z
Hadri
AgroParisTech, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; INRA, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France. Electronic address: catherine.chaumontet@agroparistech.fr.
Catherine
C
Chaumontet
AgroParisTech, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; INRA, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France.
Gilles
G
Fromentin
AgroParisTech, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; INRA, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France.
Patrick C
PC
Even
AgroParisTech, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; INRA, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France.
Nicolas
N
Darcel
Laboratoire de Bioressources Naturelles Locales, Département de Biologie, Faculté des Sciences, Université Hassiba Ben Bouali, Chlef, Algeria.
Abdelkader Dilmi
AD
Bouras
AgroParisTech, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; INRA, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France.
Daniel
D
Tomé
AgroParisTech, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France; INRA, CRNH-IdF, UMR914, Nutrition Physiology and Ingestive Behavior, F-75005 Paris, France.
Rojo
R
Rasoamanana
D050154:Adiposity / Q000187:drug effects*; D054369:Agouti-Related Protein / Q000235:genetics / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004043:Dietary Fiber / Q000008:administration & dosage; D004435:Eating / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects; D005685:Galactans / Q000008:administration & dosage*; D015870:Gene Expression / Q000187:drug effects; D008137:Longitudinal Studies; D008297:Male; D008351:Mannans / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009478:Neuropeptide Y / Q000235:genetics / Q000378:metabolism; D009844:Oligosaccharides / Q000008:administration & dosage*; D053149:Plant Gums / Q000008:administration & dosage*; D011333:Pro-Opiomelanocortin / Q000235:genetics / Q000378:metabolism; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics / Q000378:metabolism; D013997:Time Factors; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
D054369:Agouti-Related Protein; D004043:Dietary Fiber; D005685:Galactans; C574273:MC4R protein, mouse; D008351:Mannans; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D009844:Oligosaccharides; D053149:Plant Gums; D044105:Receptor, Melanocortin, Type 4; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; D011333:Pro-Opiomelanocortin; C007894:guar gum
Alginate; Food intake and adiposity; Fructo-oligosaccharide; Guar gum