I2-Catalyzed Aerobic Oxidative C(sp(3))-H Amination/C-N Cleavage of Tertiary Amine: Synthesis of Quinazolines and Quinazolinones.
An iodine-catalyzed oxidative C(sp(3))-H amination/C-N cleavage of tertiary amines couducted under an oxygen atmosphere has been developed and affords a route to quinazolines and quinazolinones in good to excellent yields via a domino ring annulation. The method is metal-free, peroxide-free, and operationally simple to implement with a wide scope of substrates and represents a new avenue for multiple C-N bond formations.
†School of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, P. R. China.|‡Henan Collaborative Innovation Center for Food Production and Safety, Zhengzhou 450000, P. R. China.
Yizhe
Y
Yan
†School of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, P. R. China.
Ying
Y
Xu
†School of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, P. R. China.
Bin
B
Niu
†School of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, P. R. China.
Huifang
H
Xie
†School of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450000, P. R. China.
Yanqi
Y
Liu