Recent Advances in Burkholderia mallei and B. pseudomallei Research.
Burkholderia malleiandBurkholderia pseudomalleiare Gram-negative organisms, which are etiological agents of glanders and melioidosis, respectively. Although onlyB. pseudomalleiis responsible for a significant number of human cases, both organisms are classified as Tier 1 Select Agents and their diseases lack effective diagnosis and treatment. Despite a recent resurgence in research pertaining to these organisms, there are still a number of knowledge gaps. This article summarizes the latest research progress in the fields ofB. malleiandB. pseudomalleipathogenesis, vaccines, and diagnostics.
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Christopher L
CL
Hatcher
Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USA.
Laura A
LA
Muruato
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA ; Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USA ; Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.
Alfredo G
AG
Torres
B. mallei; B. pseudomallei; Diagnostics; Glanders; Melioidosis; Pathogenesis; Vaccines