[The role of psycho-autonomic status and the serotonergic system in patients with gastroesophageal reflux disease].
OBJECTIVE
Identify the differences of the autonomic nervous system (ANS), serotonin levels, cognitive, behavioral and emotsinalnoy areas in groups of patients with reflux esophagitis (RE) and non-erosive reflux disease (NERD) and assess the impact on the disease.


METHODS
The study included 71 patients rith gastroesophageal reflux disease (GERD), including 29 patients with ER, 42--NERD. Diagnosis was based on anamnesis, clinical research, fibrogastrocopy, pH-metry. Tested with a scale situational and personal anxiety Spielberg Hanina, diagnostic techniques and forms of aggression indicators A. Bass and A. Dark, the Toronto aleksitimicheskoy scale method for investigating the level of subjective control, clinical questionnaire for the identification and evaluation of neurotic states, personality questionnaire Bekhterevsky Institute, cardiointervalography, orthoklinostatik and cold test, determined the level of serotonin in the blood.


RESULTS
Compared with the group of patients suffering from ER patients with NERD determined by the displacement in the direction of internality measure locus of control personality, and patients with ER, in contrast, had lower locus of control personality, a high level of situational anxiety, irritability, anxiety type of attitude to the situation of the disease associated with impaired autonomic software ANS activity.


CONCLUSIONS
Patients with ER are more pronounced changes in cognitive-emotional sphere may have an impact on the course of disease and requiring psychological, medical correction.
I A
IA
Grishechkina
D I
DI
Trukhan
D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms / Q000453:epidemiology / Q000523:psychology; D000374:Aggression / Q000523:psychology; D001007:Anxiety / Q000453:epidemiology / Q000523:psychology; D001341:Autonomic Nervous System / Q000503:physiopathology*; D003071:Cognition / Q000502:physiology; D004644:Emotions / Q000502:physiology; D004942:Esophagitis, Peptic / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism / Q000523:psychology; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism* / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011581:Psychological Tests; D012701:Serotonin / Q000097:blood*; D011795:Surveys and Questionnaires; D055815:Young Adult
D012701:Serotonin