Memantine-associated hyperkalaemia in a patient with Alzheimer's disease.
Memantine is an N-methyl-D-aspartate glutamate receptor antagonist that may improve cognitive functions in patients with Alzheimer's disease. It is predominantly excreted unchanged via the kidneys, and patients with decreased creatinine clearance must be treated with lower doses of memantine. However, it is unclear whether memantine itself can lead to renal dysfunction and/or hyperkalaemia. We report a patient with renal impairment and hyperkalaemia possibly associated with memantine administration.
Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan; Department of Psychiatry, St. Maria Hospital, Kurume, Japan.
Tatsuo
T
Tsukamoto
Hidetaka
H
Yamada
Naohisa
N
Uchimura
D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000188:drug therapy*; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D018691:Excitatory Amino Acid Antagonists / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000097:blood / Q000139:chemically induced*; D007668:Kidney / Q000187:drug effects; D008559:Memantine / Q000009:adverse effects* / Q000097:blood
D018691:Excitatory Amino Acid Antagonists; D003404:Creatinine; D008559:Memantine
Alzheimer's disease; hyperkalaemia; memantine; renal impairment