Corticobasal degeneration: clinical characteristics and multidisciplinary therapeutic approach in 26 patients.
Corticobasal syndrome (CBS) is a sporadic tauopathy that manifests by a various combination of motor and cognitive deficits, which makes its diagnosis challenging. Treatment of CBS is symptomatic and based on evidence from other similar disorders due to the lack of studies on CBS. The aim of the study was to investigate low-frequency repetitive transcranial magnetic stimulation (rTMS) as a therapeutic tool in CBS. Twenty-six patients with clinically evident CBS according to Cambridge criteria were followed for 12-18 months while receiving low-frequency rTMS combined with pharmacological, rehabilitation treatment and botulinum toxin injection. The majority of patients are manifested with akinetic-rigid syndrome and cognitive dysfunction. There was improvement of the UPDRS and quality of life after 3 months of therapeutic interventions (P < 0.001 and <0.05, respectively). No significant deterioration in cognitive functions was detected over the study period. There was a significant reduction of caregiver burden after 3 months of interventions (P < 0.01); this improvement was maintained up to 18 months. Cognitive dysfunction is a frequent manifestation of CBS. CBS patients can benefit from multidisciplinary therapeutic approach employing low-frequency rTMS.
Neurology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Hatem S
HS
Shehata
Nevin M
NM
Shalaby
Eman H
EH
Esmail
Ebtesam
E
Fahmy
D000368:Aged; D017028:Caregivers / Q000523:psychology; D002491:Central Nervous System Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D017281:Cost of Illness; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D000066530:Neurological Rehabilitation / Q000379:methods; D011446:Prospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D024801:Tauopathies / Q000503:physiopathology* / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D016896:Treatment Outcome
D002491:Central Nervous System Agents