Monkeys and Rats Are Not Susceptible to Ferret Hepatitis E Virus Infection.
Ferret hepatitis E virus (HEV), a novel hepatitis E-like virus, has been identified in ferrets in the Netherlands, Japan, and the US. To determine whether ferret HEV transmits to other animals, we inoculated laboratory rats (Wistar), nude rats (Long-Evans-rnu/rnu), and cynomolgus monkeys with ferret HEV (F4351) by intravenous injection. None of the animals demonstrated a positive sign for virus replication, indicating that rats and monkeys are not susceptible to ferret HEV.
Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Tian-Cheng
TC
Li
Sayaka
S
Yoshizaki
Yasushi
Y
Ami
Yuriko
Y
Suzaki
Tingting
T
Yang
Naokazu
N
Takeda
Wakita
W
Takaji
D000818:Animals; D004198:Disease Susceptibility / Q000662:veterinary*; D005289:Ferrets; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000635:transmission / Q000662:veterinary* / Q000821:virology; D016752:Hepatitis E virus / Q000276:immunology* / Q000502:physiology*; D008252:Macaca fascicularis; D008992:Monkey Diseases / Q000821:virology*; D012367:RNA, Viral; D051381:Rats; D020318:Rats, Long-Evans; D017208:Rats, Wistar; D012376:Rodent Diseases / Q000821:virology*; D014779:Virus Replication
D006508:Hepatitis Antibodies; D012367:RNA, Viral