[Research progress on Drynaria fortunei naringin on inflammation and bone activity].
Flavonoid naringin is widely distributed in various types of plants and is an important component of herbal Drynaria. In previous studies, Drynaria has been demonstrated to have inhibitory effects on inflammatory responses and bone destruction and exert anabolic effects on bone, has been widely used in the clinical treatment. Naringin, was in the stage of experimental yet. The experimental results have confirmed that naringin suppressed inflammation including arthritis by lowering the expression of inflammatory cytokines, and the mechanism can be explained as reducing the expression of NF-κB. Naringin has been shown to increase osteoblast proliferation by increasing the expression of BMP-2, inhibit osteoclast activity by reducing the expression of RANKL. In animal experimental, naringin was useful for osteoporosis, and the mechanisms are in-depth studies. Research in the field of traditional Chinese medicine and orthopedics, naringin as a explicit material structure in the components of Drynaria, has been concerned about the experimental studies, it is not only prosperity the development of traditional Chinese medicine research,but also ready for clinical studies anti-inflammatory and bone effects of naringin in the future.
Fang-ming
FM
Yin
Lian-bo
LB
Xiao
Yun
Y
Zhang
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects*; D044950:Flavanones / Q000494:pharmacology*; D006801:Humans; D008516:Medicine, Chinese Traditional; D010006:Osteoblasts / Q000187:drug effects; D010010:Osteoclasts / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy; D029621:Polypodiaceae / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D044950:Flavanones; C005274:naringin