[Secondary cancers: Incidence, risk factors and recommendations].
Cure rates for most childhood cancers and adolescents have made remarkable progress over the last thirty to forty years. The development of secondary malignancies has become an important question for these patients. The frequency is low, but the risk is significantly higher (between 3 and 10 times) and it is the leading cause of long-term mortality off relapse. In this literature review, we discuss the epidemiological aspect and the risk factors contributing to this increased risk, and conclude with a summary of current recommendations for screening and surveillance. We also discuss briefly the constitutional predisposing genetic contributions to other cancers.
Institut de cancérologie de l'Ouest, ICO-René Gauducheau, service de radiothérapie, boulevard J-Monod, 44800 Saint-Herblain, France; Faculté de médecine de Nantes, 44000 Nantes, France. Electronic address: charlotte.demoor@ico.unicancer.fr.
Charlotte
C
Demoor-Goldschmidt
Institut Gustave-Roussy, service d'oncologie pédiatrique, rue Camille-Des-Moulins, 94805 Villejuif, France.
Chiraz
C
Fayech
CHU de Grenoble, hôpital Couple Enfant, clinique universitaire de pédiatrie, CS10217, 38043 Grenoble cedex, France.
Pauline
P
Girard
CHU de Grenoble, hôpital Couple Enfant, clinique universitaire de pédiatrie, CS10217, 38043 Grenoble cedex, France.
Dominique
D
Plantaz
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D017408:Guidelines as Topic; D006801:Humans; D015994:Incidence; D008297:Male; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D011322:Primary Prevention; D012307:Risk Factors; D055502:Secondary Prevention; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control
D000970:Antineoplastic Agents
Breast; Cancer pédiatrique; Cancers secondaires; Pediatric cancer; Recommandation; Recommendation; Secondary cancers; Sein; Survivant; Survivor; Thyroid; Thyroïde