Autofluorescence imaging in the differential diagnosis of optic disc melanocytoma.
OBJECTIVE
Optic disc melanocytoma (ODM) is a benign tumour that usually occurs on or adjacent to the optic nerve head. The aim of the study was to evaluate fundus autofluorescence (FAF) imaging as a diagnostic tool in ODM.


METHODS
Retrospective comparative case series study of six patients with ODM and a comparing group of four patients with juxtapapillary choroidal nevus (JCN) and four with juxtapapillary uveal melanoma (JUM). Clinical examination was supplemented with ultrasound B-scan examination and spectral-domain optical coherence tomography. FAF images were obtained with the 532-nm laser (Optomap P200Tx) from all patients.


RESULTS
Clinical examination in the ODM group revealed a dome-shaped, darkly pigmented tumour on or adjacent to the optic disc in all patients, with a mean tumour basal dimension 1.4 mm and mean tumour thickness by ultrasonography of 1.0 mm. FAF revealed a totally hypofluorescent mass with sharply demarcated, feathery edges. No hyperfluorescent changes due to orange pigment or subretinal fluid were seen. In contrast, patients with JCN and JUM manifested focal hyperfluorescence as well as larger hyperfluorescent areas at the tumour and its borders.


CONCLUSIONS
Fundus autofluorescence imaging is a non-invasive adjuvant tool in the differential diagnosis of ODM characterized by lack of hyperfluorescence compared to JCN and JUM.
Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.|University of Oslo, Oslo, Norway.
Panagiotis
P
Salvanos
Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.|Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Tor P
TP
Utheim
Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.|University of Oslo, Oslo, Norway.
Morten C
MC
Moe
Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.
Nils
N
Eide
Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.|University of Oslo, Oslo, Norway.
Ragnheiður
R
Bragadόttir
D000328:Adult; D000368:Aged; D004396:Coloring Agents / Q000737:chemistry; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry; D008297:Male; D008545:Melanoma / Q000175:diagnosis*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000175:diagnosis*; D009898:Optic Disk / Q000473:pathology*; D019574:Optic Nerve Neoplasms / Q000175:diagnosis*; D061848:Optical Imaging; D015203:Reproducibility of Results; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014604:Uveal Neoplasms / Q000175:diagnosis*; D000098943:Uveal Melanoma
D004396:Coloring Agents; D007208:Indocyanine Green
autofluorescence; imaging; melanocytoma; nevus; optic disc; uveal melanoma