Pathological role of adipose tissue dysfunction in cardio-metabolic disorders.
Obesity has dramatically increased throughout the world, and has become one of the chief healthcare problems in many societies. Evidence has emerged that adipose tissue dysfunction associated with obesity is critically involved in the development of cardiovascular and metabolic disorders. In this review, we delineate the link between adipose tissue abnormalities and systemic metabolic dysfunction in patients with cardio-metabolic diseases and discuss the underlying mechanisms.
1.Cardiovascular Biology and Medicine; 2. Department of Molecular Aging and Cell Biology, Niigata University Graduate School of Medical and Dental Sciences Niigata, Japan.
Ippei
I
Shimizu
Yohko
Y
Yoshida
Tohru
T
Minamino
D000273:Adipose Tissue / Q000503:physiopathology*; D002001:Adipose Tissue, Brown / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000209:etiology*; D006321:Heart / Q000503:physiopathology; D006801:Humans; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology; D008659:Metabolic Diseases / Q000209:etiology*; D009765:Obesity / Q000503:physiopathology
D007328:Insulin