A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- Pyridylmethyl)amine (tpa) As An Inhibitor Of Beta-amyloid Fibrillation.
We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO(4) 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. sharonlf.chan@polyu.edu.hk.
Sharon Lai-Fung
SL
Chan
Lihua
L
Lu
Tsz Lung
TL
Lam
Siu-Cheong
SC
Yan
Chung-Hang
CH
Leung
Dik-Lung
DL
Ma
D016229:Amyloid beta-Peptides / Q000378:metabolism*; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D010446:Peptide Fragments / Q000378:metabolism*; D066329:Protein Aggregates / Q000187:drug effects*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
D016229:Amyloid beta-Peptides; D018696:Neuroprotective Agents; D010446:Peptide Fragments; D066329:Protein Aggregates; D011725:Pyridines; C078592:amyloid beta-protein (1-40); C431843:tris(2-pyridylmethyl)amine; D012428:Ruthenium