Association of Attention Deficit Disorder With Bedside Anti-saccades in Survivors of Childhood Leukemia.
Impaired attention is well recognized in childhood cancer survivors. We prospectively evaluated 162 long-term survivors of childhood acute lymphoblastic leukemia to study an association between presence of neurologic soft signs as measured by Zurich Neuromotor Scale, bedside evaluation of anti-saccades, and attention deficit disorder. Attention deficit disorder was recognized in 10.5% of the study cohort. We did not find an association of attention deficit with presence of any soft sign. However, there was an association between presence of abnormal anti-saccades and attention deficit (P = .04). These results will require further validation and if confirmed may introduce a quick bedside method of assessing impaired attention in cancer survivors.
Division of Neurology, St. Jude Children's Research Hospital, Memphis, TN, USA raja.khan@stjude.org.
Raja B
RB
Khan
Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.
Melissa M
MM
Hudson
Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kirsten K
KK
Ness
Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Zhu
Z
Liang
Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Deokumar
D
Srivastava
Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN, USA.
Kevin R
KR
Krull
D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D000067716:Point-of-Care Testing; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D011569:Psychiatric Status Rating Scales; D012438:Saccades; D012720:Severity of Illness Index; D017741:Survivors; D055815:Young Adult
acute lymphoblastic leukemia; anti-saccades; attention deficit disorder; childhood; soft signs