Kaempferol, a dietary flavonoid, ameliorates acute inflammatory and nociceptive symptoms in gastritis, pancreatitis, and abdominal pain.
Kaempferol (KF) is the most abundant polyphenol in tea, fruits, vegetables, and beans. However, little is known about its in vivo anti-inflammatory efficacy and mechanisms of action. To study these, several acute mouse inflammatory and nociceptive models, including gastritis, pancreatitis, and abdominal pain were employed. Kaempferol was shown to attenuate the expansion of inflammatory lesions seen in ethanol (EtOH)/HCl- and aspirin-induced gastritis, LPS/caerulein (CA) triggered pancreatitis, and acetic acid-induced writhing.
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Shi Hyoung
SH
Kim
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Jae Gwang
JG
Park
Institute for Bio-medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung, Republic of Korea.|International St. Mary's Hospital, Catholic Kwandong University, Incheon, Republic of Korea.
Gi-Ho
GH
Sung
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Sungjae
S
Yang
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Woo Seok
WS
Yang
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Eunji
E
Kim
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Jun Ho
JH
Kim
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Van Thai
VT
Ha
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Han Gyung
HG
Kim
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Young-Su
YS
Yi
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Ji Hye
JH
Kim
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Kwang-Soo
KS
Baek
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Nak Yoon
NY
Sung
Department of Food and Nutrition, School of Foodservice Industry, Chungkang College of Cultural industries, Icheon, Republic of Korea.
Mi-nam
MN
Lee
Department of Veterinary Physiology, College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Jeonju, Republic of Korea.
Jong-Hoon
JH
Kim
Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
Jae Youl
JY
Cho
D015746:Abdominal Pain / Q000188:drug therapy*; D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001241:Aspirin / Q000009:adverse effects; D002108:Ceruletide / Q000009:adverse effects; D004195:Disease Models, Animal; D005756:Gastritis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D044949:Kaempferols / Q000494:pharmacology*; D051379:Mice; D059225:Nociception / Q000187:drug effects*; D010195:Pancreatitis / Q000139:chemically induced / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D044949:Kaempferols; C006552:kaempferol; D002108:Ceruletide; D019342:Acetic Acid; D001241:Aspirin
Abdominal pain; Anti-inflammatory effect; Gastritis; Kaempferol; Pancreatitis