IL-17A, IL-22, and IL-23 as Markers of Psoriasis Activity: A Cross-sectional, Hospital-based Study.
BACKGROUND
T-helper 1 (Th1), Th17 cells, and their related cytokines are implicated in psoriasis pathogenesis although the contribution of each group of cytokines in psoriasis activity has not been fully clarified.


OBJECTIVE
To investigate whether Th17-related cytokines are associated with psoriasis activity.


METHODS
The serum levels of interleukin (IL)-1β, 6, 8, 17Α, 22, 23, and tumor necrosis factor-α (TNFα) were measured with flow cytometry in 35 patients with plaque psoriasis (21 with stable and 14 with active disease) and in 20 healthy controls.


RESULTS
Interleukin-6, 8, 17A, 22, 23, and TNFα were significantly elevated in psoriasis patients compared with controls. In the sensitivity analyses, patients with active disease showed significantly increased levels of IL-17A, IL-23, and IL-22 as compared to the group of patients with stable psoriasis.


CONCLUSIONS
Our study highlights a possible crucial role of IL-17A, IL-22, and IL-23 in the activity of psoriasis and the early stages of the disease.
First Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece cifotiadou@hotmail.com.
Christina
C
Fotiadou
First Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece.
Elizabeth
E
Lazaridou
First Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece.
Eleni
E
Sotiriou
First Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece.
Spiridon
S
Gerou
Department of Otolaryngology, Head and Neck Surgery, Aristotle University Medical School, Thessaloniki, Greece.
Athanasios
A
Kyrgidis
First Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece.
Efstratios
E
Vakirlis
First Department of Dermatology-Venereology, Aristotle University Medical School, Thessaloniki, Greece.
Demetris
D
Ioannides
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000473:pathology*; D012680:Sensitivity and Specificity; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
D015415:Biomarkers; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha
IL-17; IL-22; IL-23; Th-17-related cytokines; psoriasis; psoriasis activity