Anti-inflammatory and cytotoxic compounds from Solanum macaonense.
One new cerebroside, macaocerebroside A (1), and 15 known compounds (2-16) were isolated from Solanum macaonense for the first time. In an antineutrophilic inflammatory assay, four caffeic acid derivatives (2-5) were active against superoxide anion generation with IC50 values of 3.3-4.8 μM; especially, 3 inhibited elastase release with an IC50 value of 4.0 μM. Additionally, kaempferol (8) also showed inhibition against elastase release with an IC50 value of 4.0 μM. In a cytotoxic assay, rutin (14) had selective moderate cytotoxicity toward human lung (A549), bladder (NTUB1), and prostate (DU145) cancer cell lines with IC50 values of 34.6, 41.3, and 31.8 μM, respectively.
Chia-Lin
CL
Lee
Tsong-Long
TL
Hwang
Chieh-Yu
CY
Peng
Chao-Jung
CJ
Chen
Chao-Lin
CL
Kuo
Wen-Yi
WY
Chang
Yang-Chang
YC
Wu
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry; D032322:Solanum / Q000737:chemistry*; D013481:Superoxides
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D013481:Superoxides