Recognizing and managing sepsis: what needs to be done?
Sepsis is associated with significant morbidity and mortality if not promptly recognized and treated. Since the development of early goal-directed therapy, mortality rates have decreased, but sepsis remains a major cause of death in patients arriving at the emergency department or staying in hospital. In this forum article, we asked clinicians and researchers with expertise in sepsis care to discuss the importance of rapid detection and treatment of the condition, as well as special considerations in different patient groups.
University of Pittsburgh, Pittsburgh, PA, USA. yeaslydm@upmc.edu.|UPMC, 200 Lothrop St., Pittsburgh, PA, 15213-2582, USA. yeaslydm@upmc.edu.
Donald M
DM
Yealy
University of Pittsburgh, Pittsburgh, PA, USA. huangdt@upmc.edu.|UPMC, 200 Lothrop St., Pittsburgh, PA, 15213-2582, USA. huangdt@upmc.edu.
David T
DT
Huang
Malcolm Fisher Department of Intensive Care Medicine, Level 6, Acute Services Building, Royal North Shore Hospital, Reserve Road, St. Leonards, Sydney, NSW, 2065, Australia. adelaney@med.usyd.edu.au.|Northern Clinical School, Sydney Medical School, University of Sydney, Reserve Road, St. Leonards, Sydney, NSW, 2065, Australia. adelaney@med.usyd.edu.au.|Department of Epidemiology and Preventative Medicine, Australian and New Zealand Intensive Care Research Centre, Monash University, The Alfred Centre, 99 Commercial Road, Melbourne, VIC, 304, Australia. adelaney@med.usyd.edu.au.
Anthony
A
Delaney
National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Old Rd Campus, Oxford, OX3 7LF, UK. marian.knight@npeu.ox.ac.uk.
Marian
M
Knight
Department of Anesthesia, Perioperative and Pain Medicine, Critical Care Division, Boston Children's Hospital, Bader 634, 300 Longwood Avenue, Boston, MA, 02115, USA. adrienne.randolph@childrens.harvard.edu.|Department of Anesthesia, Harvard Medical School, Boston, MA, 02115, USA. adrienne.randolph@childrens.harvard.edu.
Adrienne G
AG
Randolph
Heart of England NHS Foundation Trust, UK Sepsis Trust, Sutton Coldfield, West Midlands, B72 1NE, UK. ron@sepsistrust.org.
Ron
R
Daniels
Department of Emergency Medicine, Derriford Hospital, Plymouth, DL6 8DH, UK. timnutbeam@nhs.net.|University of Plymouth, Drake Circus, Plymouth, Devon, PL4 8AA, UK. timnutbeam@nhs.net.
Tim
T
Nutbeam
D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D018805:Sepsis / Q000175:diagnosis* / Q000628:therapy*