Tumor twitter: cellular communication in the breast cancer stem cell niche.
Communication between the diverse assortment of cells that constitute the tumor microenvironment plays an important role in tumor development. Using a p53-null mouse model, Zhang and colleagues describe a novel feedback loop involving breast cancer stem cells and their progeny mediated by WNT2, CXCL12, and IL6.
Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Michael D
MD
Brooks
Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan. mwicha@med.umich.edu.
Max S
MS
Wicha
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53