Myeloid cells in hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is highly associated with inflammation. Myeloid cells, including tumor-associated macrophages and myeloid-derived suppressor cells, are abundant in the HCC microenvironment and are often associated with poor prognosis. Myeloid cells in HCC play a vital role in supporting tumor initiation, progression, angiogenesis, metastasis, and therapeutic resistance. Here, we summarize our current knowledge about myeloid cells in HCC and focus on their immune-suppressive activities and tumor-promoting functions, as well as the relevance to potential new therapies in HCC.
Section of Transplantation, University of Michigan, Ann Arbor, MI.|Department of Surgery, University of Michigan, Ann Arbor, MI.
Shanshan
S
Wan
Section of Transplantation, University of Michigan, Ann Arbor, MI.|Department of Surgery, University of Michigan, Ann Arbor, MI.
Ning
N
Kuo
Department of Surgery, University of Michigan, Ann Arbor, MI.
Ilona
I
Kryczek
Department of Surgery, University of Michigan, Ann Arbor, MI.
Weiping
W
Zou
Section of Transplantation, University of Michigan, Ann Arbor, MI.|Department of Surgery, University of Michigan, Ann Arbor, MI.
Theodore H
TH
Welling
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008113:Liver Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D051379:Mice; D022423:Myeloid Cells / Q000502:physiology*