What should be done in thyroid nodules less than two centimeters, ultrasonographically suspicious and cytologically benign?
OBJECTIVE
Although fine needle aspiration biopsy has a high sensitivity in thyroid nodule assessment, ultrasonography findings should not be underestimated. With this study, we aimed to evaluate cytologically benign nodules smaller than two centimeters, where ultrasonography findings were suspicious.


METHODS
Thirty-one patients undergoing thyroidectomy between January 2009 and January 2013 were included in this retrospectively designed study. Thyroid ultrasonography and thyroid fine needle aspiration biopsy (FNAB) results were evaluated. Ultrasonographically, all patients had multinodular tissue formation and nodules had at least one of the suspicious features (nodules with hypoechogenicity, irregular margins, absence of halo, taller-than-wide, increased vascularity and microcalcifications). Maximum size of the nodules was 2 cm. Thyroidectomy was performed in this ultrasonographically suspicious, but cytologically benign group due to clinical suspicion, cosmetic reasons or patient preference.


RESULTS
All patients underwent a total thyroidectomy. The group consisted of 27 female and 4 male patients, with a mean age of 49.5 years. According to the final pathology reports, there were 13 (41.9%) multinodular goiters, 2 (6.4%) follicular adenomas, 1 (3.2%) Hashimoto's thyroiditis and 15 (48.3%) thyroid cancers. Patients with cancer had at least two suspicious ultrasound findings. Except five patients with papillary microcarcinoma, cancer was diagnosed in ultrasonographically suspicious nodules in all patients. The percentage of patients with benign FNAB results, but with at least two suspicious ultrasound findings of malignancy in the biopsied nodules, was 32.2%.


CONCLUSIONS
FNAB remains to be the gold standard in the management of ultrasonographically suspicious nodules smaller than 2 centimeters. Nevertheless, due to its high sensitivity, in case of presence of suspicious features on ultrasonography, we believe that thyroidectomy should be a treatment option if there is a clinical suspicion and the patient carries at least two suspicious ultrasonography findings.
Department of General Surgery, Faculty of Medicine, Ege University, İzmir, Turkey.
Mevlüt
M
Çahalov
Department of General Surgery, Faculty of Medicine, Ege University, İzmir, Turkey.
Özer
Ö
Makay
Department of General Surgery, Faculty of Medicine, Ege University, İzmir, Turkey.
Gökhan
G
İçöz
Department of General Surgery, Faculty of Medicine, Ege University, İzmir, Turkey.
Mahir
M
Akyıldız
Department of General Surgery, Faculty of Medicine, Ege University, İzmir, Turkey.
Mustafa
M
Yılmaz
Thyroid nodule; fine needle aspiration biopsy; ultrasonography