Is plasma soluble CD36 associated with cardiovascular risk factors in early onset coronary artery disease patients?
OBJECTIVE
This is the first study to investigate the relationship between plasma concentration of soluble CD36 (sCD36) and CD36 gene polymorphisms as well as clinical and echocardiographic parameters in patients with early onset coronary artery disease (CAD).


METHODS
sCD36 concentrations were measured by the ELISA kits. CD36 sequence alterations detected by the DHPLC technique comprised single nucleotide substitutions: rs3173798, rs3211892, rs5956 and rs141680676.


RESULTS
There were significant negative correlations between sCD36 and red blood cell count, hemoglobin, hematocrit and glucose concentration, ApoB/ApoA1 ratio, patients' weight and waist circumference, BMI, WHR, systolic blood pressure, MAP values, left ventricular end-diastolic diameter and volume, left atrium diameter, right ventricular end-diastolic diameter. There were significant positive correlations between sCD36 and patients' age, mean corpuscular volume of erythrocytes, HDL-cholesterol, ApoA1 concentrations. Significantly higher CD36 plasma levels were found in female subgroup. There was no association between CD36 genotypes and sCD36 concentrations. Multiple linear regression analysis revealed that significant independent predictors of higher plasma sCD36 level were female gender, older age, lower serum glucose and lower RBC.


CONCLUSIONS
The presented data suggest possible protective effects of higher sCD36 concentration in relation to metabolic syndrome components in CAD patients. Higher sCD36 concentration is also associated with lower risk of left ventricular hypertrophy, but on the other hand is a potential risk factor of impaired left ventricle diastolic function.
Department of Cardiology, County Hospital in Szczecin , Szczecin , Poland.
Andrzej
A
Krzystolik
Violetta
V
Dziedziejko
Krzysztof
K
Safranow
Grzegorz
G
Kurzawski
Michał
M
Rać
Dagmara
D
Sagasz-Tysiewicz
Wojciech
W
Poncyljusz
Katarzyna
K
Jakubowska
Dariusz
D
Chlubek
Monika E
ME
Rać
D000328:Adult; D001483:Base Sequence; D018955:CD36 Antigens / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012995:Solubility; D014463:Ultrasonography
D018955:CD36 Antigens
CD36; Coronary artery disease; ELISA; echocardiography; left ventricular hypertrophy