Association of plasma diamine oxidase and intestinal fatty acid-binding protein with severity of disease in patient with heat stroke.
OBJECTIVE
The aim of this study was to describe the role of intestinal fatty acid-binding protein (iFABP) and allergy-related diamine oxidase (DAO) in patients with heat stroke (HS).


METHODS
A total of 10 patients with HS in intensive care unit and 10 healthy volunteers were enrolled in this study. The plasma intestinal permeability markers iFABP and DAO were measured since the time of admission. The whole blood endotoxin was also assessed. The associations between iFABP, DAO, and endotoxin level were analyzed. Then, white blood cell count, procalcitonin, and C-reactive protein were examined. In addition, we also determined the levels of proinflammatory cytokines such as IL-1α, IL-6, and TNF-α.


RESULTS
Comparing with the healthy control, the plasma iFABP and DAO level in patients with HS increased significantly (P < .05). The kinetic curve showed that plasma iFABP and DAO level reached peak value at day 3 and day 4 after admission, respectively. The endotoxin level was positively correlated with iFABP and DAO level. We also observed a significantly increased level of procalcitonin and C-reactive protein but not white blood count in patients with HS. After treatment, the iFABP and DAO level decreased significantly (P < .05). A significant increase in level of IL-1α and IL-6 was also found in patients with HS.


CONCLUSIONS
The plasma concentrations of DAO and iFABP could reflect a better function of the intestinal mucosa barrier in patients with HS. Plasma iFABP and DAO level decreased significantly after the treatment and, thus, might be a predictor for the severity of HS.
Emergency and Intensive Care Center for Chemical Accident, Jinshan Hospital affiliated to Fudan University, Shanghai, 201508, China.
Lin
L
Zhang
Department of Gastroenterology, Jinshan Hospital of Fudan University, Shanghai, 201508, China.
Xiaoming
X
Fan
Emergency and Intensive Care Center for Chemical Accident, Jinshan Hospital affiliated to Fudan University, Shanghai, 201508, China.
Zhiyue
Z
Zhong
Department of Center Laboratory, Jinshan Hospital of Fudan University, Shanghai, 201508, China.
Guoxiong
G
Xu
Emergency and Intensive Care Center for Chemical Accident, Jinshan Hospital affiliated to Fudan University, Shanghai, 201508, China. Electronic address: j1999sh@163.com.
Jie
J
Shen
D000328:Adult; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D004731:Endotoxins / Q000097:blood; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D018883:Heat Stroke / Q000097:blood* / Q000628:therapy; D006801:Humans; D053582:Interleukin-1alpha / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010539:Permeability; D011498:Protein Precursors / Q000097:blood; D018805:Sepsis / Q000097:blood / Q000150:complications; D012720:Severity of Illness Index; D012769:Shock / Q000097:blood / Q000150:complications; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
C000606589:CALCA protein, human; D016207:Cytokines; D004731:Endotoxins; C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins; C508584:IL1A protein, human; C508600:IL6 protein, human; D053582:Interleukin-1alpha; D015850:Interleukin-6; D011498:Protein Precursors; D014409:Tumor Necrosis Factor-alpha; D002116:Calcitonin; D002097:C-Reactive Protein; D006631:Amine Oxidase (Copper-Containing); D015740:Calcitonin Gene-Related Peptide