Ultraviolet B Inhibits Skin Wound Healing by Affecting Focal Adhesion Dynamics.
As the most important interface between human body and external environment, skin acts as an essential barrier preventing various environmental damages, among which DNA-damaging UV radiation from the sun remains the major environmental risk factor causing various skin diseases. It has been well documented that wavelengths in the ultraviolet B (UVB) radiation range (290-320 nm) of the solar spectrum can be absorbed by skin and lead to cutaneous injury and various other deleterious effects. During process such as wound healing, the orchestrated movement of cells in a particular direction is essential and highly regulated, integrating signals controlling adhesion, polarity and the cytoskeleton. Cell adhesion and migration are modulated through both of actin and microtubule cytoskeletons. However, little was known about how UVB affects skin wound healing and migration of epidermal keratinocytes. Here, we demonstrate that UVB can delay the wound healing progress in vivo with a murine model of full-thickness skin wound. In addition, UVB significantly inhibited keratinocyte motility by altering focal adhesion turnover and cytoskeletal dynamics. Our results provide new insights into the etiology of UVB exposure-induced skin damages.
Ben May Department for Cancer Research, The University of Chicago, Chicago, IL.
Han
H
Liu
Ben May Department for Cancer Research, The University of Chicago, Chicago, IL.
Jiping
J
Yue
Section of Dermatology, Department of Medicine, The University of Chicago, Chicago, IL.
Qiang
Q
Lei
Ben May Department for Cancer Research, The University of Chicago, Chicago, IL.
Xuewen
X
Gou
Department of Pharmacology and Toxicology, University of Louisville Health Science Center, Louisville, KY.
Shao-Yu
SY
Chen
Section of Dermatology, Department of Medicine, The University of Chicago, Chicago, IL.
Yu-Ying
YY
He
Ben May Department for Cancer Research, The University of Chicago, Chicago, IL.
Xiaoyang
http://orcid.org/0000-0001-6378-3207
X
Wu
D000818:Animals; D002478:Cells, Cultured; D022001:Focal Adhesions; D051379:Mice; D012871:Skin Diseases / Q000628:therapy*; D014466:Ultraviolet Rays; D014945:Wound Healing