Inflammatory mediators in vascular disease: identifying promising targets for intracranial aneurysm research.
Inflammatory processes are implicated in many diseases of the vasculature and have been shown to play a key role in the formation of intracranial aneurysms (IAs). Although the specific mechanisms underlying these processes have been thoroughly investigated in related pathologies, such as atherosclerosis, there remains a paucity of information regarding the immunopathology of IA. Cells such as macrophages and lymphocytes and their effector molecules have been suggested to be players in IA, but their specific interactions and the role of other components of the inflammatory response have yet to be determined. Drawing parallels between the pathogenesis of IA and other vascular disorders could provide a roadmap for developing a mechanistic understanding of the immunopathology of IA and uncovering useful targets for therapeutic intervention. Future research should address the presence and function of leukocyte subsets, mechanisms of leukocyte recruitment and activation, and the role of damage-associated molecular patterns in IA.
Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
David M
DM
Sawyer
Department of Neurosurgery, Tulane University School of Medicine, 131 S. Robertson Street, Suite 1300, No. 8047, New Orleans, LA 70112, USA.
Peter S
PS
Amenta
Department of Neurosurgery, Tulane University School of Medicine, 131 S. Robertson Street, Suite 1300, No. 8047, New Orleans, LA 70112, USA.
Ricky
0000-0003-3188-7823
R
Medel
Department of Neurosurgery, Tulane University School of Medicine, 131 S. Robertson Street, Suite 1300, No. 8047, New Orleans, LA 70112, USA.
Aaron S
AS
Dumont
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000938:Antigen-Presenting Cells / Q000166:cytology; D001402:B-Lymphocytes / Q000166:cytology; D003713:Dendritic Cells / Q000166:cytology; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000502:physiology; D002532:Intracranial Aneurysm / Q000276:immunology* / Q000628:therapy; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D051379:Mice; D012307:Risk Factors; D015398:Signal Transduction; D014652:Vascular Diseases / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators