An estrogen-associated dietary pattern and breast cancer risk in the Swedish Mammography Cohort.
High endogenous hormone levels have been associated with breast cancer and dietary factors have the potential to influence breast cancer risk through effects on hormone levels. Dietary patterns derived from reduced rank regression provide a way to identify food groups correlated with hormones and subsequently examine food patterns that may be associated with breast cancer risk. We investigated whether a dietary pattern previously correlated with estradiol and estrone sulfate was associated with breast cancer in the prospective Swedish Mammography Cohort. Among 37,004 primarily postmenopausal women diet was assessed with a food frequency questionnaire. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs). During 15 years of follow-up 1,603 cases of breast cancer were identified. A higher estrogen dietary pattern score was associated with an increased risk of breast cancer. Women in the highest quartile of estrogen pattern score had a 29% (95% CI = 1.08-1.55) increased risk of breast cancer compared to women in the lowest quartile (p(trend) = 0.006). When the association was examined by estrogen-receptor status, it was only significant for those with estrogen-receptor-positive tumors; however, in the competing risk analysis there were no significant differences in the effect estimates by receptor subtype (p(heterogeneity) = 0.65). Our findings suggest that a dietary pattern associated with higher estrogen levels may increase breast cancer risk. However, whether the influence of this dietary pattern is through a direct effect on estrogen levels deserves further study.
Division of Nutritional Epidemiology, National Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.|Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA.
Holly R
HR
Harris
Department of Surgery and Centre for Clinical Research, Central Hospital, Västerås, Sweden.
Leif
L
Bergkvist
Division of Nutritional Epidemiology, National Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Alicja
A
Wolk
D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D004032:Diet; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000031:analogs & derivatives / Q000097:blood; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D042361:Mammary Glands, Human / Q000473:pathology; D008327:Mammography; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology
D004970:Estrone; D004958:Estradiol; C017296:estrone sulfate
breast cancer; dietary pattern; epidemiology; estrogen