Synthesis and Structure of a New Copper(II) Coordination Polymer Alternately Bridged by Oxamido and Carboxylate Groups: Evaluation of DNA/BSA Binding and Cytotoxic Activities.
A new one-dimensional (1D) copper(II) coordination polymer {[Cu2 (dmaepox)(dabt)](NO3) · 0.5 H2 O}n , where H3 dmaepox and dabt denote N-benzoato-N'-(3-methylaminopropyl)oxamide and 2,2'-diamino-4,4'-bithiazole, respectively, was synthesized and characterized by single-crystal X-ray diffraction and other methods. The crystal structure analysis revealed that the two copper(II) ions are bridged alternately by cis-oxamido and carboxylato groups to form a 1-D coordination polymer with the corresponding Cu · · · Cu separations of 5.1946(19) and 5.038(2) Å. There is a three-dimensional supramolecular structure constructed by hydrogen bonding and π-π stacking interactions in the crystal. The reactivity towards herring sperm DNA (HS-DNA) and bovine serum albumin (BSA) indicated that the copper(II) polymer can interact with the DNA in the mode of intercalation, and bind to BSA responsible for quenching of tryptophan fluorescence by the static quenching mechanism. The in vitro cytotoxicity suggested that the copper(II) polymer exhibits cytotoxic effects against the selected tumor cell lines.
School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.
Xiao-Ting
XT
Jin
School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China.
Kang
K
Zheng
School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People's Republic of China. yantuanli@ouc.edu.cn.
Yan-Tuan
YT
Li
Key Laboratory of Marine Drug, Chinese Ministry of Education, Ocean University of China, Qingdao, 266003, People's Republic of China.
Zhi-Yong
ZY
Wu
College of Marine Life Science, Ocean University of China, Qingdao, 266003, People's Republic of China. cuiweiyan@ouc.edu.cn.
Cui-Wei
CW
Yan
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism; D006801:Humans; D007364:Intercalating Agents / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D015394:Molecular Structure; D011485:Protein Binding; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013844:Thiazoles / Q000737:chemistry
C524586:2,2'-diamino-4,4'-bithiazole; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D007364:Intercalating Agents; D013844:Thiazoles; D012710:Serum Albumin, Bovine; D003300:Copper; D004247:DNA
1-D Copper(II) Coordination Polymer, Oxamidato-Bridge, DNA/BSA Binding, In Vitro Anticancer Activity; Crystal structure