Serum creatinine levels during and after long-term treatment with cyclosporine A in patients with severe atopic dermatitis.
Safety data with respect to kidney function during long-term treatment with cyclosporine A (CsA) in patients with atopic dermatitis is limited. Data on serum creatinine levels before, during and after CsA treatment were collected in a retrospective cohort of adult patients with atopic dermatitis. The median duration of treatment of 150 patients was 280 days (interquartile range 203-528 days). There was a significant, but not clinically relevant, increase in serum creatinine compared with the baseline level after 3 weeks of treatment with CsA and stabilization during the maintenance phase at the group level. Twenty-two (14.7%) patients had a greater than 30% increase in serum creatinine (cut-off point for clinically relevant change) compared with baseline. These patients were significantly older than the patients without a 30% increase (mean ± standard deviation age 41.4 ± 15.6 vs. 33.8 ± 11.7 years (p = 0.01)). During follow-up, all patients had a less than 30% increase in serum creatinine levels compared with baseline levels. At the group level serum creatinine levels during follow-up were not significantly different from baseline.
Department of Dermatology and Allergology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands. j.vanderschaft-5@umcutrecht.nl.
Jorien
J
van der Schaft
Arjan D
AD
van Zuilen
Joukje
J
Deinum
Carla A F M
CA
Bruijnzeel-Koomen
Marjolein S
MS
de Bruin-Weller
D000328:Adult; D000367:Age Factors; D003404:Creatinine / Q000097:blood*; D016572:Cyclosporine / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D060046:Maintenance Chemotherapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D055815:Young Adult
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine