Different effects of the BIM deletion polymorphism on treatment of solid tumors by the tyrosine kinase inhibitors (TKI) pazopanib, sunitinib, and lapatinib.
GlaxoSmithKline Research and Development, Stevenage, UK colin.f.spraggs@gsk.com.
C F
CF
Spraggs
PAREXEL International, Durham, Philadelphia, USA.
L R
LR
Parham
GlaxoSmithKline Research and Development, Philadelphia, USA.
K
K
Song
PAREXEL International, Durham, Philadelphia, USA.
L P
LP
Briley
GlaxoSmithKline Research and Development, Stevenage, UK.
T
T
Johnson
GlaxoSmithKline Research and Development, Philadelphia, USA.
M
M
Russo
GlaxoSmithKline Research and Development, Philadelphia, USA.
H
H
Tada
Kliniken Essen-Mitte, Essen, Germany.
A
A
du Bois
GlaxoSmithKline Research and Development, Stevenage, UK.
C-F
CF
Xu
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D000072224:Bcl-2-Like Protein 11; D017353:Gene Deletion; D006801:Humans; D007191:Indazoles; D007211:Indoles / Q000627:therapeutic use*; D000077341:Lapatinib; D008565:Membrane Proteins / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011446:Prospective Studies; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011743:Pyrimidines / Q000627:therapeutic use*; D011758:Pyrroles / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects; D013449:Sulfonamides / Q000627:therapeutic use*; D000077210:Sunitinib
D020533:Angiogenesis Inhibitors; D051017:Apoptosis Regulatory Proteins; C000606775:BCL2L11 protein, human; D000072224:Bcl-2-Like Protein 11; D007191:Indazoles; D007211:Indoles; D008565:Membrane Proteins; D047428:Protein Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D011743:Pyrimidines; D011758:Pyrroles; D011799:Quinazolines; D013449:Sulfonamides; D000077341:Lapatinib; C516667:pazopanib; D000077210:Sunitinib