Recent Concise Viewpoints of Chronic Active Epstein-Barr Virus Infection.
Chronic active Epstein-Barr virus infection (CAEBV) is characterized mainly by prolonged or intermittent fever, lymphadenopathy and hepatosplenomegaly without definite underlying diseases at the diagnosis. Patients with CAEBV also may have various life-threatening conditions including hematological, neurological, pulmonary, cardiac, digestive tract, ocular and/or dermal disorders. Additionally, during the course of illness, they often develop hematological malignancies such as T cell, NK cell or B cell lymphoproliferative disorder (LPD) and/or lymphoma. No causative pathogenetic mechanisms have been sufficiently clarified, and additionally no promising efficacious treatment was demonstrated except for the hematopoietic stem cell transplantation (HSCT) in cases who develop T cell or NK cell LPD or lymphoma. This minireview outlines the recent development for the comprehensive viewpoints of CAEBV mainly regarding to virological, immunological, pathological and therapeutical progresses.
Hokkaido Institute of Public Health, 1-1, North 19 West 12, Kita-ku, Sapporo 060-0819, Japan. okano_m@iph.pref.hokkaido.jp.
Motohiko
M
Okano
D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004279:DNA, Viral; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D004854:Herpesvirus 4, Human / Q000472:pathogenicity*; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology / Q000821:virology*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000821:virology*; D016896:Treatment Outcome
D004279:DNA, Viral; D011948:Receptors, Antigen, T-Cell