Omics Approaches Toward Defining the Comprehensive Abscisic Acid Signaling Network in Plants.
ABA is a plant hormone that plays crucial roles in controlling cellular and physiological responses to osmotic stress and in developmental processes. Endogenous ABA levels are increased in response to a decrease in water availability in cells, and ABA sensing and signaling are thought to be mediated according to the current model established in Arabidopsis thaliana, which involves pyrabactin resistance 1 (PYR)/PYR1-like (PYL)/regulatory components of ABA receptor (RCAR), protein phosphatase 2C (PP2C) and sucrose non-fermenting-1 (SNF1)-related protein kinase 2 (SnRK2). These core components of ABA signaling have a pivotal role in stress-responsive gene expression and stomatal regulation. However, because a limited number of their upstream and downstream factors have been characterized, it is still difficult to define the comprehensive network of ABA signaling in plants. This review focuses on current progress in the study of PYR/PYL/RCARs, PP2Cs and SnRK2s, with particular emphasis on omics approaches, such as interactome and phosphoproteome studies. Moreover, the role of ABA in plant growth and development is discussed based on recent metabolomic profiling studies.
Laboratory of Plant Molecular Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657 Japan.
Takuya
T
Yoshida
Laboratory of Plant Molecular Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657 Japan.
Junro
J
Mogami
Laboratory of Plant Molecular Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, 113-8657 Japan akys@mail.ecc.u-tokyo.ac.jp.
Kazuko
K
Yamaguchi-Shinozaki
D000040:Abscisic Acid / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism*; D010944:Plants / Q000378:metabolism*; D000071636:Protein Phosphatase 2C; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction
D010750:Phosphoproteins; D000040:Abscisic Acid; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C
Abscisic acid; Arabidopsis; Omics studies; Protein phosphatase 2C (PP2C); Pyrabactin resistance 1 (PYR)/PYR1-like (PYL)/Regulatory components of ABA receptor (RCAR); Sucrose non-fermenting-1 (SNF1)-related protein kinase 2 (SnRK2)