Current focus of stem cell application in retinal repair.
The relevance of retinal diseases, both in society's economy and in the quality of people's life who suffer with them, has made stem cell therapy an interesting topic for research. Embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adipose derived mesenchymal stem cells (ADMSCs) are the focus in current endeavors as a source of different retinal cells, such as photoreceptors and retinal pigment epithelial cells. The aim is to apply them for cell replacement as an option for treating retinal diseases which so far are untreatable in their advanced stage. ESCs, despite the great potential for differentiation, have the dangerous risk of teratoma formation as well as ethical issues, which must be resolved before starting a clinical trial. iPSCs, like ESCs, are able to differentiate in to several types of retinal cells. However, the process to get them for personalized cell therapy has a high cost in terms of time and money. Researchers are working to resolve this since iPSCs seem to be a realistic option for treating retinal diseases. ADMSCs have the advantage that the procedures to obtain them are easier. Despite advancements in stem cell application, there are still several challenges that need to be overcome before transferring the research results to clinical application. This paper reviews recent research achievements of the applications of these three types of stem cells as well as clinical trials currently based on them.
María L Alonso-Alonso, Girish K Srivastava, Instituto Universitario de Obtalmobiología Aplicada (IOBA), Universidad de Valladolid, 47011 Valladolid, Spain.
María L
ML
Alonso-Alonso
María L Alonso-Alonso, Girish K Srivastava, Instituto Universitario de Obtalmobiología Aplicada (IOBA), Universidad de Valladolid, 47011 Valladolid, Spain.
Girish K
GK
Srivastava
Adipose derived mesenchymal stem cells; Cell therapy; Embryonic stem cells; Induced pluripotent stem cells; Retina