Germline MUTYH gene mutations are not frequently found in unselected patients with papillary breast carcinoma.
MUTYH-associated polyposis (MAP) is an autosomal recessive disease, which predisposes to polyposis and colorectal cancer. There is a trend towards an increased risk of breast cancer in MAP patients, with a remarkable proportion of papillary breast cancers. To determine whether MUTYH mutations are associated with this specific and rare type of breast cancer, 53 unselected patients with papillary breast cancer were analyzed for founder mutations in the MUTYH gene. No germline mutations were identified, indicating that biallelic MUTYH mutations are not a frequent underlying cause for the development of papillary carcinomas of the breast.
Department of Human Genetics, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Ewout P
EP
Boesaard
Department of Human Genetics, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Ingrid P
IP
Vogelaar
Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands.
Peter
P
Bult
Department of Pathology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
Carla Ap
CA
Wauters
Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands.
J Han Jm
JH
van Krieken
Department of Human Genetics, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands ; Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands.
Marjolijn Jl
MJ
Ligtenberg
Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands.
Rachel S
RS
van der Post
Department of Human Genetics, Radboud university medical center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Nicoline
N
Hoogerbrugge
MUTYH; MUTYH-associated polyposis; Papillary carcinomas of the breast