Regulation of body fat mass by the gut microbiota: Possible mediation by the brain.
New insight suggests gut microbiota as a component in energy balance. However, the underlying mechanisms by which gut microbiota can impact metabolic regulation is unclear. A recent study from our lab shows, for the first time, a link between gut microbiota and energy balance circuitries in the hypothalamus and brainstem. In this article we will review this study further.
Institute of Neuroscience and Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden.
Erik
E
Schéle
The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden.
Louise
L
Grahnemo
Institute of Neuroscience and Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden.
Fredrik
F
Anesten
The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark.
Anna
A
Hallén
The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark. Electronic address: Fredrik.Backhed@wlab.gu.se.
Fredrik
F
Bäckhed
Institute of Neuroscience and Physiology/Endocrinology, The Sahlgrenska Academy at the University of Gothenburg, S-413 45 Gothenburg, Sweden. Electronic address: john-olov.jansson@medic.gu.se.
John-Olov
JO
Jansson
D050154:Adiposity; D000818:Animals; D001069:Appetite Regulation; D001921:Brain / Q000502:physiology*; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology; D004734:Energy Metabolism; D000069196:Gastrointestinal Microbiome; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D009765:Obesity / Q000378:metabolism / Q000382:microbiology / Q000601:surgery
D019208:Brain-Derived Neurotrophic Factor
BDNF; GLP-1; Gut microbiota; Obesity