The value of HCG serum concentrations after trigger in predicting pregnancy and live birth rates in IVF-ICSI.
The aim of this study was to determine if an association existed between serum human chorionic gonadotrophin (HCG) level at 12 h after trigger and IVF and intracytoplasmic sperm (ICSI) treatment outcomes. Women undergoing initial IVF-ICSI and embryo transfer treatment using the long luteal phase gonadotrophin-releasing hormone agonist protocol between April 2012 and March 2013 for tubal factor were included (n = 699). In the clinical pregnancy group, HCG after trigger was significantly elevated (276.0 ± 5.1 versus 198.5 ± 6.1 mIU/mL; P < 0.001). The optimal cut-off value proposed by the receiver operating characteristic analysis (area under curve = 0.730) for HCG was 201.2 mIU/ml. Compared with the lower HCG group, the clinical pregnancy rate in the higher HCG group was increased in obese and non-obese patients (77.8% versus 57.3%, P < 0.05; 85.6% versus 53.0%, P < 0.01, respectively). Adjusted for age and body mass index, an increase of HCG was associated with a better IVF-ICSI treatment outcome (OR 4.39, 95% CI 2.99 to 6.45). Clinical pregnancy rate was significantly higher across increasing quartiles of HCG. An elevated level of serum HCG at 12 h after trigger was associated with a better IVF-ICSI outcome.
Reproductive Medicine Center, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
Jianjun
J
Zhou
Reproductive Medicine Center, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
Shanshan
S
Wang
Reproductive Medicine Center, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
Bin
B
Wang
Reproductive Medicine Center, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
Junxia
J
Wang
Reproductive Medicine Center, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
Hua
H
Chen
Reproductive Medicine Center, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
Ningyuan
N
Zhang
Reproductive Medicine Center, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China.
Yali
Y
Hu
Reproductive Medicine Center, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China. Electronic address: stevensunz@163.com.
Haixiang
H
Sun
D001723:Birth Rate; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic
D006063:Chorionic Gonadotropin
HCG; ICSI; IVF; pregnancy