Comparison of Saline-Irrigated Catheter vs. Temperature-Controlled Catheter for Renal Denervation in a Canine Model.
BACKGROUND
The effectiveness of catheter-based renal denervation (RDN) remains controversial. Although the reasons for this have not yet been elucidated, ineffective denervation appears to be an important factor. The present study aimed to investigate the difference in RDN between a saline-irrigated catheter (SIC) and a temperature-controlled catheter (TCC).


METHODS
Dogs (n = 6) from the Kunming province in Chinese were ablated; the SIC was introduced into the right renal artery, while the TCC was introduced into the left renal artery. After 6 months, histopathology and renal angiography were performed, and the change in neural density was evaluated using morphometric software. The average values of heart rate (HR), blood pressure (BP), and catecholamine metabolites were assessed at baseline and follow-up.


RESULTS
Histopathology showed nerve demyelination and denaturation, as well as interstitial hyperplasia, although these changes were more pronounced when the SIC was used. The change in neural density was greater and ablation was deeper when the SIC was used. Intimal hyperplasia was greater when the TCC was used, whereas medial hyperplasia was greater when the SIC was used. A trend toward a decrease in HR, BP, metanephrine, and normetanephrine between baseline and follow-up was observed.


CONCLUSIONS
Our findings suggest that SIC ablation results in more extensive neural degeneration, deeper penetration, and less extensive intimal hyperplasia than TCC ablation for RDN.
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Zhenglong
Z
Wang
Shaojie
S
Chen
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Tingquan
T
Zhou
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Li
L
Su
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Zhiyu
Z
Ling
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Jinqi
J
Fan
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Weijie
W
Chen
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Huaan
H
Du
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Jiayi
J
Lu
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Yanping
Y
Xu
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Zhen
Z
Tan
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Hanxuan
H
Yang
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Xinyu
X
Hu
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Chengzhi
C
Li
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Xue
X
Yan
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Guangxin
G
Hu
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;
Chang
C
Liu
Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; excellentchenshaojie@126.com yinyh63@163.com.
Yuehui
Y
Yin
D000792:Angiography; D000818:Animals; D001794:Blood Pressure; D002395:Catecholamines / Q000378:metabolism; D003714:Denervation / Q000295:instrumentation*; D004195:Disease Models, Animal; D004285:Dogs; D006339:Heart Rate; D006965:Hyperplasia; D006973:Hypertension / Q000601:surgery*; D009412:Nerve Fibers / Q000648:ultrastructure; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000294:innervation* / Q000473:pathology; D062666:Vascular Access Devices
D002395:Catecholamines
blood pressure; degeneration; histopathology; hypertension; intimal hyperplasia; medial hyperplasia; renal denervation; saline-irrigated catheter; temperature-controlled catheter.