[Prognostic significance of monosomal karyotype in acute myeloid leukemia].
OBJECTIVE
To explore the prognostic significance of monosomal karyotype (MK) in patients with acute myeloid leukemia (AML).


METHODS
The clinical data of 498 AML patients were analyzed retrospectively.


RESULTS
Of the 498 patients, 233 (46.8%) cases had an abnormal karyotype. 42 patients fulfilled the criteria for MK, which were 8.4% of all cases and 18.0% of patients with abnormal karyotype, respectively. The most frequent autosomal monosomies were -7 and -17. 70 patients had complex karyotype (CK), in all patients and patients with abnormal karyotype accounted for 14.1% and 30.0%, respectively. Patients with MK were associated with significantly older (median age 62.5 vs 52 years, P=0.003), and lower HGB concentrations (62.5 vs 77 g/L, P=0.009) and lower WBC counts (7.0×10⁹/L vs 11.7×10⁹/L, P=0.008). Among MK cases, the most frequent chromosome abnormalities were complex karyotype, -7, -5, 7q-, and 5q-. In univariate analysis, MK patients had worse survival than those without MK (7.3 months vs 26.3 months, P<0.001). CK patients also had poorer outcomes than patients without CK (14.8 months vs 26.3 months, P<0.001). In CK patients, survival was worse in MK patients than patients without MK (7.4 months vs 19.2 months, P=0.007). By COX analysis, MK was an independent prognostic factor, beyond NCCN criteria and CK [HR=2.610 (1.632-4.175), P<0.001].


CONCLUSIONS
MK was an independent adverse prognostic factor in AML patients.
Department of Hematology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China.
Yanyan
Y
Luan
Department of Hematology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China.
Junqing
J
Xu
Department of Hematology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China.
Baohua
B
Huang
Department of Hematology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China.
Xiaoqian
X
Liu
Department of Hematology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China.
Yinghui
Y
Liu
Department of Hematology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China.
Liming
L
Chen
Department of Hematology, Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai 264000, China.
Xiaoxia
X
Chu
D059786:Abnormal Karyotype; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute; D009006:Monosomy; D011379:Prognosis; D012189:Retrospective Studies