Cox17 Protein Is an Auxiliary Factor Involved in the Control of the Mitochondrial Contact Site and Cristae Organizing System.
The mitochondrial contact site and cristae organizing system (MICOS) is a recently discovered protein complex that is crucial for establishing and maintaining the proper inner membrane architecture and contacts with the outer membrane of mitochondria. The ways in which the MICOS complex is assembled and its integrity is regulated remain elusive. Here, we report a direct link between Cox17, a protein involved in the assembly of cytochrome c oxidase, and the MICOS complex. Cox17 interacts with Mic60, thereby modulating MICOS complex integrity. This interaction does not involve Sco1, a partner of Cox17 in transferring copper ions to cytochrome c oxidase. However, the Cox17-MICOS interaction is regulated by copper ions. We propose that Cox17 is a newly identified factor involved in maintaining the architecture of the MICOS complex.
From the International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland and.
Magdalena
M
Chojnacka
From the International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland and.
Agnieszka
A
Gornicka
the Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
Silke
S
Oeljeklaus
the Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany.
Bettina
B
Warscheid
From the International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland and achacinska@iimcb.gov.pl.
Agnieszka
A
Chacinska
D027682:Cation Transport Proteins / Q000378:metabolism / Q000502:physiology*; D002846:Chromatography, Affinity; D000079922:Copper Transport Proteins; D018832:Molecular Chaperones / Q000378:metabolism / Q000502:physiology*; D011485:Protein Binding; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism / Q000502:physiology*
C100359:COX17 protein, S cerevisiae; D027682:Cation Transport Proteins; D000079922:Copper Transport Proteins; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins
Cox17; MICOS; Sco1; inner membrane architecture; membrane; metal; mitochondria; organelle; protein complex