Before or after: is there a connection between the use of adjunctive nonmelanoma skin cancer treatments and subsequent invasive tumors?
Although the therapeutic gold standard for basal cell carcinomas (BCCs) is surgical excision, imiquimod, fluorouracil cream, and photodynamic therapy are frequently used. All 3 modalities have been shown to be efficacious for the treatment of superficial BCCs as well as other nonmelanoma skin cancers; however, recent reports have emerged implicating these agents in causing more aggressive recurrent subtypes of BCCs. Here we review this literature as well as offer an alternative explanation for these tumors.
Emily Stamell
ES
Ruiz
Joel L
JL
Cohen
Adam
A
Friedman
D000634:Aminoquinolines / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002280:Basal Cell Carcinoma / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D000077271:Imiquimod; D009364:Neoplasm Recurrence, Local; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology / Q000628:therapy*
D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod; D005472:Fluorouracil