Locoregional therapy of hepatocellular carcinoma.
Hepatocellular carcinoma can be treated using minimally invasive, image-guided, catheter-based or percutaneous techniques. Such procedures offer compelling clinical outcomes with a favorable side-effect profile in a population of patients who are poor candidates for surgical or systemic treatment. This article discusses key data regarding the effectiveness of locoregional therapies in treating these patients. Disease-specific treatment is discussed in the context of hepatocellular carcinoma, with additional data discussed in the context of transplantation. As rapid innovation occurs in the realm of oncology, interventional oncology represents a safe, effective alternative that continues to generate impressive data that could potentially change treatment paradigms.
Section of Interventional Radiology, Division of Interventional Oncology, Department of Radiology, Northwestern University, Chicago, IL, USA.
Ali
A
Habib
Section of Interventional Radiology, Division of Interventional Oncology, Department of Radiology, Northwestern University, Chicago, IL, USA.
Kush
K
Desai
Section of Interventional Radiology, Division of Interventional Oncology, Department of Radiology, Northwestern University, Chicago, IL, USA.
Ryan
R
Hickey
Section of Interventional Radiology, Division of Interventional Oncology, Department of Radiology, Northwestern University, Chicago, IL, USA.
Bartley
B
Thornburg
Section of Interventional Radiology, Division of Interventional Oncology, Department of Radiology, Northwestern University, Chicago, IL, USA.
Robert
R
Lewandowski
Vascular and Interventional Radiology, Image-Guided Therapy, Section of Interventional Radiology, Division of Interventional Oncology, Department of Radiology, Northwestern University, 676 North St. Clair, Suite 800, Chicago, IL 60611, USA. Electronic address: r-salem@northwestern.edu.
Riad
R
Salem
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000628:therapy*; D017115:Catheter Ablation; D016461:Chemoembolization, Therapeutic; D003452:Cryosurgery; D053672:Electrochemotherapy; D000431:Ethanol / Q000008:administration & dosage; D006801:Humans; D015552:Injections, Intralesional; D008113:Liver Neoplasms / Q000175:diagnosis / Q000628:therapy*; D008872:Microwaves / Q000627:therapeutic use; D015021:Yttrium Radioisotopes / Q000008:administration & dosage
D000970:Antineoplastic Agents; D015021:Yttrium Radioisotopes; D000431:Ethanol
Hepatocellular carcinoma; Interventional oncology; Locoregional therapies; Percutaneous ethanol injection; Radioembolization; Radiofrequency ablation; Transarterial chemoembolization; Transplantation