Four lanostane-type triterpenes from the fruiting bodies of mushroom Laetiporus sulphureus var. miniatus.
Two new 3,4-seco-lanostane-type triterpenes, named as 15α-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid (1), 5α-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid 3-methyl ester (2), and one new lanostane triterpene 15α-acetoxylhydroxytrametenolic acid (3) together with a known one versisponic acid D (4) were isolated from the fruiting bodies of Laetiporus sulphureus var. miniatus. Their structures were determined on the basis of extensive spectroscopic methods and comparison with reported data. All four compounds were evaluated for their cytotoxicities against five human cancer cell lines; however, none exhibited inhibitory effects.
a College of Science, Northwest A&F University , Yangling 712100 , China.
Xia
X
Yin
Zheng-Hui
ZH
Li
Yan
Y
Li
Tao
T
Feng
Ji-Kai
JK
Liu
D000363:Agaricales / Q000737:chemistry*; D002681:China; D004354:Drug Screening Assays, Antitumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D007810:Lanosterol
Laetiporus sulphureus; basidiomycetes; cytotoxicities; lanostane-type triterpenes