Bilberry extract supplementation for preventing eye fatigue in video display terminal workers.
OBJECTIVE
To examine the effect of a dietary supplement containing bilberry extract (BE) on eye fatigue induced by acute video display terminal (VDT) loads.


METHODS
A prospective, randomized, double-blind, placebo-controlled study was performed from August 2012 to February 2013 in the Medical Corporation Jico-kai Yagi Hospital, and the Shinyokohama Shinoharaguchi Orthopedic Surgery and Dermatology Clinic, in Japan.


METHODS
Two hundred eighty-one office workers aged 20-40 years that used VDTs were screened by critical flicker fusion (CFF) and near point accommodation (NPA).


METHODS
The participants were randomized to either a BE (480 mg/day) or placebo (vehicle) group, and took allocated capsule, daily, for 8 weeks.


METHODS
The CFF, NPA, contrast visual acuity, functional visual acuity, keratoconjunctival epithelial damage, and fluorescein tear film break-up time were examined, and 18 subjective symptoms of eye fatigue were evaluated by questionnaire. Adverse events were reported via medical interviews. Data were collected both before and after VDT load at baseline, and 4, and 8 weeks after daily supplementation with either BE or placebo.


RESULTS
Of 281 participants screened, 88 having relatively lower levels of CFF and NPA were enrolled in the study. Of these, 37 control and 43 BE group subjects completed the study. The VDT load-induced reduction in CFF was alleviated after 8 weeks of BE supplementation (95% confidence interval, 0.10-1.60; p=0.023), in contrast to placebo supplementation, while NPA variation was not. Of the subjective symptoms of eye fatigue, VDT load-induced ocular fatigue sensation, ocular pain, eye heaviness, uncomfortable sensation, and foreign body sensation were mitigated more in the BE group than in the control group, at week 8 (p<0.05). There were no severe adverse events in either group.


CONCLUSIONS
BE supplementation improved some of the objective and subjective parameters of eye fatigue induced by VDT loads.
Kazuo Tsubota M.D., Ph.D. Professor and Chairman, Department of Ophthalmology, Keio University School of Medicine; 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Phone: +81-3-3353-1211, Fax: +81-3-3359-8302,E-mail: tsubota@z3.keio.jp.
Y
Y
Ozawa
M
M
Kawashima
S
S
Inoue
E
E
Inagaki
A
A
Suzuki
E
E
Ooe
S
S
Kobayashi
K
K
Tsubota
D000328:Adult; D001248:Asthenopia / Q000178:diet therapy* / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D016288:Computer Terminals; D003228:Conjunctiva / Q000187:drug effects / Q000473:pathology; D019587:Dietary Supplements / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D011795:Surveys and Questionnaires; D013666:Tears; D029800:Vaccinium myrtillus / Q000737:chemistry*; D014792:Visual Acuity / Q000187:drug effects* / Q000502:physiology*; D055815:Young Adult
D010936:Plant Extracts