Pleural-based neuroblastoma-like schwannoma: a case report with cytologic findings and review of literature.
We report a rare case of a 45-year-old African American woman with Neuroblastoma-like Schwannoma (Neurilemmoma) occurring in the posterior mediastinum as a pleural-based mass noted on computed tomography (CT) scan. A CT-guided core biopsy of the mass was performed and core biopsy imprints were prepared during the procedure. A Diff-Quik stain was performed for on-site evaluation of specimen adequacy. The hematoxylin and eosin (H&E) staining was evaluated subsequently. Immunohistochemistry panels were applied to the same specimen. The cytologic findings of the core biopsy imprints showed hypercellular smears with a predominance of small cells with atypical features including hyperchromatic, round nuclei and occasional nucleoli. Neurocytic rosettes were particularly appreciated on H&E stain. The immunohistochemical results exhibited strong and diffuse immunoreactivity for S-100 and vimentin. This case enriches the cytopathology literature by providing awareness of this tumor presenting as a posterior mediastinal mass.
Cytology Division, Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi.
Kristen
K
Adams
Principle Diagnostics Labs, Bethlehem, Pennsylvania.
Xuehui Susan
XS
Liu
Cytology Division, Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi.
Israh
I
Akhtar
Cytology Division, Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi.
Rhyne
R
Flowers
Cytology Division, Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi.
Mithra
M
Baliga
D014408:Biomarkers, Tumor / Q000378:metabolism*; D004801:Eosine Yellowish-(YS); D005260:Female; D006416:Hematoxylin; D006801:Humans; D061705:Image-Guided Biopsy; D007150:Immunohistochemistry; D008482:Mediastinum / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009442:Neurilemmoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D009418:S100 Proteins / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000378:metabolism*
D014408:Biomarkers, Tumor; D009418:S100 Proteins; D014746:Vimentin; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin
core biopsy; cytology; mediastinum; neuroblastoma-like schwannoma