The androgen receptor for the radiation oncologist.
Androgen deprivation therapy is widely used in combination with radiotherapy for the treatment of prostate cancer. The knowledge of the biology of the androgen axis could help the radiation oncologist to combine both modalities in an efficient way. Moreover, new drugs have recently been approved and their role in combination with radiation needs pre-clinical and clinical studies. This review summarized the main data on the biology of androgen receptor and the potential implications for the physician. Mechanisms of interactions between androgen deprivation therapy and radiotherapy are also presented and discussed.
Oncologie-radiothérapie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75475 Paris, France.
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Quero
Institut mutualiste Montsouris, 42, boulevard Jourdan, 75014 Paris, France.
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Rozet
Institut Curie, 26, rue d'Ulm, 75005 Paris, France.
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Beuzeboc
Oncologie-radiothérapie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75475 Paris, France. Electronic address: christophe.hennequin@sls.aphp.fr.
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Hennequin
D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy*; D017398:Alternative Splicing; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000728:Androgens; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D015972:Gene Expression Regulation, Neoplastic; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors; D006801:Humans; D008297:Male; D009363:Neoplasm Proteins / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D009376:Neoplasms, Hormone-Dependent / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy*; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy*; D012333:RNA, Messenger / Q000235:genetics; D011944:Receptors, Androgen / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D013739:Testosterone / Q000096:biosynthesis / Q000097:blood; D014158:Transcription, Genetic
D000726:Androgen Antagonists; D000728:Androgens; D018931:Antineoplastic Agents, Hormonal; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D011944:Receptors, Androgen; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone
Androgen receptor; Cancer de la prostate; Prostate cancer; Radiotherapy; Radiothérapie; Récepteur aux androgènes