Effects of CYP2C19 and P2Y12 Gene Polymorphisms on Clinical Results of Patients Using Clopidogrel after Acute Ischemic Cerebrovascular Disease.
The CY2C19 and P2Y12 gene polymorphisms are responsible for resistance to clopidogrel, known as drug unresponsiveness. In this study we researched the effect of gene polymorphism on clinical results of patients who began clopidogrel therapy after acute ischemic cerebrovascular disease. The study included 51 patients. The patient group included patients who had begun prophylactic clopidogrel due to acute ischemic cerebrovascular disease in the last 2 years. All patients were monitored by the Neurology Outpatient Clinic at Çanakkale Onsekiz Mart Üniversity Research Hospital, Çanakkale, Turkey, and only those monitored for at least 1 year were included in the study. When the *1, *2 and *3 alleles of the CYP2C19 gene polymorphism were evaluated, two patients were homozygotes for *2/*2, 13 patients were heterozygous for *1/*2 and 36 patients were homozygotes for the wild type *1/*1. No patient had the *3 allele. Three heterozygous patients, one for *2/*2 and two for *1/*2, stopped clopidogrel therapy due to repeated strokes and began taking warfarin. When evaluating P2Y12 52 (G>T) and 34 (C>T) polymorphisms, all alleles were of the wild type. The CYP2C19 and P2Y12 gene polymorphisms may cause recurring strokes linked to insufficient response to treatment of ischemic cerebrovascular disease. In our patient group, three patients suffered repeated strokes and these patients had the CYP2C19*2 gene polymorphism. As a result, before medication use, genetic testing is important for human life, quality of life and economic burden.
Department of Neurology, School of Medicine, Çanakkale Onsekiz Mart Üniversity, Çanakkale, Turkey.
H M
HM
Sen
Department of Medical Genetics, School of Medicine, Çanakkale Onsekiz Mart Üniversity, Çanakkale, Turkey.
F
F
Silan
Department of Pharmacology, School of Medicine, Çanakkale Onsekiz Mart Üniversity, Çanakkale, Turkey.
C
C
Silan
Department of Neurology, School of Medicine, Düzce Üniversity, Düzce, Düzce, Turkey.
Y
Y
Degirmenci
Department of Neurology, School of Medicine, Çanakkale Onsekiz Mart Üniversity, Çanakkale, Turkey.
H I
HI
Ozisik Kamaran
CYP2C19 and P2Y12 gene polymorphisms; Ischemic cerebrovascular disease (ICVD); clopidogrel