NGAL and ST2 levels in ambulatory patients with chronic heart failure. Clinical and echocardiographic correlates.
OBJECTIVE
Neutrophil gelatinase-associated lipocalin (NGAL) and ST2 receptor, a member of the interleukin-1 receptor family, are novel biomarkers with a potential role in the diagnosis and risk stratification of patients with chronic heart failure (CHF). There is however scarce data on their relation with clinical characteristics and cardiac function in patients with CHF.


METHODS
Consecutive ambulatory patients with CHF were studied. All patients underwent clinical and echocardiographic assessment, and blood samples were collected for the estimation of ST2 and NGAL serum levels during the same assessment.


RESULTS
A total of 76 patients (79% male, mean age: 63 ± 14 years), with CHF and left ventricular ejection fraction of 28 ± 7% were included. Median NGAL was 0.16 (0.09-0.275) mg/L and median ST2 was 0.0125 (0.0071-0.0176) mg/L. No association between NGAL and ST2 was observed. Multivariate analysis revealed tissue Doppler-derived right ventricular systolic velocity as an independent predictor of ST2, and the duration of HF and serum creatinine levels as independent predictors of NGAL.


CONCLUSIONS
NGAL levels depend on the renal function and the duration of HF, while ST2 levels are affected by the right but not the left ventricular function and show no association with clinical indices of HF.
1st Department of Cardiology, AHEPA University Hospital , Thessaloniki , Greece.
Ioannis
I
Ventoulis
Lilian
L
Mantziari
Sophia-Anastasia
SA
Mouratoglou
Vasileios
V
Kamperidis
George
G
Giannakoulas
Antonios
A
Ziakas
Dimitris
D
Tsalikakis
Gregory
G
Giamouzis
Areti
A
Hitoglou-Makedou
Haralambos
H
Karvounis
D000209:Acute-Phase Proteins; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015150:Echocardiography, Doppler; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D016014:Linear Models; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000097:blood*; D011956:Receptors, Cell Surface / Q000097:blood*; D013318:Stroke Volume; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right
D000209:Acute-Phase Proteins; D015415:Biomarkers; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface
chronic heart failure; echocardiography; novel biomarkers