Is the scavenger receptor MARCO a new immune checkpoint?
Whereas macrophages use the scavenger receptor MARCO primarily in antimicrobial immunity by interacting with both exogenous and endogenous environments, in dendritic cells (DCs) MARCO is believed to pleiotropically link innate to adaptive immunity. MARCO exerts a significant modulatory effect on TLR-induced DC activation, thus offering novel avenues in cancer immunotherapy.
Department of Surgery; Beth Israel Deaconess Medical Center; Harvard Medical School ; Boston, MA USA.
Mohamed S
MS
Arredouani
DC, dendritic cell; ICI, immune checkpoint inhibitor; LPS, lipopolysaccharide; MARCO, macrophage receptor with collagenous structure; PAMP, pathogen-associated molecular pattern; PKA, protein kinase A; SHP-2, Src-homology 2 domain (SH2)-containing; SR, scavenger receptor; TLR, Toll-like receptor; Toll-like receptor; cancer immunotherapy; dendritic cell activation; immune checkpoint inhibitor; scavenger receptor MARCO