Postoperative C-reactive protein measurement predicts the severity of complications following surgery for colorectal cancer.
OBJECTIVE
Studies have shown that postoperative serum C-reactive protein (CRP) measurement may be useful in predicting the type of complication, infective or otherwise, following surgery for colorectal cancer. It may be that the magnitude of the postoperative CRP is also associated with the severity of the complication. The aim of the present study was to examine the relationship between daily postoperative CRP concentrations and Clavien-Dindo complication grade.


METHODS
Data was recorded prospectively for patients undergoing elective, potentially curative, surgery for colorectal cancer in two hospitals between January 2011 and January 2013, n = 241. All patients had daily CRP measurement following surgery for the first four postoperative days. Complications were retrospectively classified by Clavien-Dindo grade.


RESULTS
Of the 241 patients, the majority were male (59%) and were over 65 years old (69%). The majority had colonic (86%) and node negative (65%) disease. One hundred nineteen patients (49%) developed a complication, and 28 (12%) of these were Clavien-Dindo grade 3, 4 or 5. Median and established threshold CRP concentrations on postoperative days 2 (>190 mg/L), 3 (>170 mg/L) and 4 (>125 mg/L) were directly associated with an increase in the Clavien-Dindo grade (all p < 0.001).


CONCLUSIONS
There was a direct association between exceeding established postoperative day 2, 3 and 4 CRP thresholds and the severity of complications defined by the Clavien-Dindo grade.
Academic Unit of Surgery, School of Medicine, University of Glasgow, New Lister Building, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G4 0SF, UK, s.mcsorley@doctors.org.uk.
Stephen T
ST
McSorley
Michelle L
ML
Ramanathan
Paul G
PG
Horgan
Donald C
DC
McMillan
D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery*; D003107:Colorectal Surgery / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000097:blood* / Q000209:etiology*; D011184:Postoperative Period
D002097:C-Reactive Protein