Fondaparinux in pregnancy: Could it be a safe option? A review of the literature.
During pregnancy thrombo-prophylaxis could be required in high risk women. If a severe allergic reaction to low-molecular-weight-heparin (LMWH) or a heparin-induced-thrombocytopenia (HIT) occurs, it's mandatory to stop the drug. Fondaparinux could be an effective option. In the present review, the maternal and pregnancy outcomes of 65 pregnancies in women using Fondaparinux were reported. It was well-tolerated and rate of pregnancy complications was similar to that observed in general population. Regarding congenital malformations, further studies are necessary to investigate the safety of the drug.
Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, L.go A. Gemelli 8, 00168, Rome, Italy. Electronic address: saradecarolis@libero.it.
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De Carolis
Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, L.go A. Gemelli 8, 00168, Rome, Italy. Electronic address: elviradp1@hotmail.it.
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di Pasquo
Institute of Hematology, Department of Medical Sciences, Catholic University of Sacred Heart, L.go A. Gemelli 8, 00168, Rome, Italy. Electronic address: elena.rossi@rm.unicatt.it.
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Rossi
Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, L.go A. Gemelli 8, 00168, Rome, Italy. Electronic address: gelsomina_delsordo@hotmail.it.
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Del Sordo
Institute of Allergology, Department of Medical Sciences, Catholic University of Sacred Heart, L.go A. Gemelli 8, 00168, Rome, Italy. Electronic address: alessandrobuonomo@hotmail.com.
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Buonomo
Institute of Allergology, Department of Medical Sciences, Catholic University of Sacred Heart, L.go A. Gemelli 8, 00168, Rome, Italy. Electronic address: dschiavino@rm.unicatt.it.
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Schiavino
Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, L.go A. Gemelli 8, 00168, Rome, Italy. Electronic address: alanzone@rm.unicatt.it.
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Lanzone
Institute of Hematology, Department of Medical Sciences, Catholic University of Sacred Heart, L.go A. Gemelli 8, 00168, Rome, Italy. Electronic address: valerio.destefano@rm.unicatt.it.
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De Stefano
D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D000077425:Fondaparinux; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D018811:Maternal Exposure; D061214:Patient Safety; D011134:Polysaccharides / Q000009:adverse effects / Q000627:therapeutic use*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D012306:Risk; D013921:Thrombocytopenia / Q000139:chemically induced / Q000517:prevention & control; D013927:Thrombosis / Q000517:prevention & control*
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; D011134:Polysaccharides; D000077425:Fondaparinux