Optical detection of middle ear infection using spectroscopic techniques: phantom experiments.
A noninvasive optical technique, which is based on a combination of reflectance spectroscopy and gas in scattering media absorption spectroscopy, is demonstrated. It has the potential to improve diagnostics of middle ear infections. An ear phantom prepared with a tissue cavity, which was covered with scattering material, was used for spectroscopic measurements. Diffuse reflectance spectra of the phantom eardrum were measured with a reflectance probe. The presence of oxygen and water vapor as well as gas exchange in the phantom cavity were studied with a specially designed fiber-optic probe for backscattering detection geometry. The results suggest that this method can be developed for improved clinical detection of middle ear infection.
South China Normal University, University City Campus, Center for Optical and Electromagnetic Research, Research Building 5, 510006 Guangzhou, China.
Hao
H
Zhang
South China Normal University, University City Campus, Center for Optical and Electromagnetic Research, Research Building 5, 510006 Guangzhou, China.
Jing
J
Huang
South China Normal University, University City Campus, Center for Optical and Electromagnetic Research, Research Building 5, 510006 Guangzhou, China.
Tianqi
T
Li
South China Normal University, University City Campus, Center for Optical and Electromagnetic Research, Research Building 5, 510006 Guangzhou, ChinabLund University, Lund Laser Center, P.O. Box 118, SE-221 00 Lund, Sweden.
Sune
S
Svanberg
South China Normal University, University City Campus, Center for Optical and Electromagnetic Research, Research Building 5, 510006 Guangzhou, ChinabLund University, Lund Laser Center, P.O. Box 118, SE-221 00 Lund, Sweden.
Katarina
K
Svanberg
D015415:Biomarkers / Q000032:analysis; D004432:Ear, Middle / Q000737:chemistry*; D005740:Gases / Q000032:analysis*; D006801:Humans; D057054:Molecular Imaging / Q000379:methods; D010033:Otitis Media / Q000175:diagnosis* / Q000378:metabolism; D010100:Oxygen / Q000032:analysis*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000379:methods*; D014867:Water / Q000032:analysis*
D015415:Biomarkers; D005740:Gases; D014867:Water; D010100:Oxygen