Herpes Simplex [corrected] Virus Type 2 Shedding From Male Circumcision Wounds in Rakai, Uganda.
A prospective observational study of 176 men coinfected with human immunodeficiency virus and herpes simplex virus type 2 (HSV-2) was conducted to assess whether their sexual partners may be at an increased risk of HSV-2 from male circumcision (MC) wounds. Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedding. Prevalence risk ratios (PRRs) were estimated using Poisson regression. Detectable penile HSV-2 shedding was present in 9.7% of men (17 of 176) before MC, compared with 12.9% (22 of 170) at 1 week (PRR, 1.33; 95% confidence interval [CI], .74-2.38) and 14.8% (23 of 155) at 2 weeks (PRR, 1.50; 95% CI, .86-2.62) after MC. HSV-2 shedding was lower among men with healed MC wounds (adjusted PRR, 0.62; 95% CI, .35-1.08). Men undergoing MC should be counseled on sexual abstinence and condom use.
Department of Epidemiology, Bloomberg School of Public Health.
Mary K
MK
Grabowski
Rakai Health Sciences Program, Entebbe.
Godfrey
G
Kigozi
Department of Epidemiology, Bloomberg School of Public Health Rakai Health Sciences Program, Entebbe.
Ronald H
RH
Gray
Departments of Medicine.
Benjamin
B
Armour
Departments of Medicine.
Jordyn
J
Manucci
Rakai Health Sciences Program, Entebbe Institute of Public Health, Makerere University, Kampala, Uganda.
David
D
Serwadda
Departments of Medicine Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Andrew D
AD
Redd
Rakai Health Sciences Program, Entebbe.
Fred
F
Nalugoda
Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Eshan U
EU
Patel
Department of Epidemiology, Bloomberg School of Public Health Rakai Health Sciences Program, Entebbe.
Maria J
MJ
Wawer
Departments of Medicine Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Rakai Health Sciences Program, Entebbe.
Thomas C
TC
Quinn
Department of Epidemiology, Bloomberg School of Public Health Pathology, School of Medicine, Johns Hopkins University, Baltimore Rakai Health Sciences Program, Entebbe.
Aaron A R
AA
Tobian
D000293:Adolescent; D000328:Adult; D002944:Circumcision, Male; D018562:Disease Transmission, Infectious / Q000517:prevention & control; D015658:HIV Infections / Q000150:complications; D006558:Herpes Genitalis / Q000453:epidemiology / Q000821:virology*; D018258:Herpesvirus 2, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D018570:Risk Assessment; D014454:Uganda; D017201:Virus Shedding; D014947:Wounds and Injuries / Q000821:virology*; D055815:Young Adult
Uganda; herpes simplex virus type 2 (HSV-2); human immunodeficiency virus (HIV); male circumcision; penile viral shedding; viral load