Spiroboronate Si-rhodamine as a near-infrared probe for imaging lysosomes based on the reversible ring-opening process.
A cyclic boronate structure was incorporated into Si-rhodamine to design a pH-activatable near-infrared (NIR) probe based on the reversible ring-opening process triggered by H(+). The probe showed general suitability of specific labelling of acidic lysosomes and tracking their pH changes in living cells.
College of Pharmacy, Yantai University, Yantai, Shandong 264005, China.
Weiwei
W
Zhu
Xiaoyun
X
Chai
Baogang
B
Wang
Yan
Y
Zou
Ting
T
Wang
Qingguo
Q
Meng
Qiuye
Q
Wu
D000818:Animals; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008247:Lysosomes / Q000378:metabolism*; D057054:Molecular Imaging; D016716:PC12 Cells; D051381:Rats; D012235:Rhodamines / Q000737:chemistry* / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D019265:Spectroscopy, Near-Infrared; D013148:Spironolactone / Q000737:chemistry* / Q000378:metabolism
D005456:Fluorescent Dyes; D012235:Rhodamines; D013148:Spironolactone