N-methylation of amines with methanol at room temperature.
N-Methylation of amines with methanol proceeds at room temperature in the presence of a silver-loaded titanium dioxide (Ag/TiO2) photocatalyst under UV-vis light irradiation. This method allows facile synthesis/isolation of N-methylamines bearing various functional groups including N-benzyl, N-allyl, N-Boc, hydroxyl, ether, acetal, carboxamide, formamide, and olefin groups.
†Research Center for Materials Science and Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Vasily N
VN
Tsarev
†Research Center for Materials Science and Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Yuna
Y
Morioka
†Research Center for Materials Science and Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Joaquim
J
Caner
†Research Center for Materials Science and Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Qing
Q
Wang
†Research Center for Materials Science and Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Richiro
R
Ushimaru
‡Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjyuku, Tokyo 162-8601, Japan.
Akihiko
A
Kudo
†Research Center for Materials Science and Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Hiroshi
H
Naka
†Research Center for Materials Science and Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.|§Institute for Advanced Research, Nagoya University, Chikusa, Nagoya 464-8601, Japan.|⊥JST, ACT-C, 3-14-23 Kamiosaki, Shinagawa, Tokyo 141-0021, Japan.
Susumu
S
Saito