Linking primary and metastatic tumour re-initiation.
Whether the cancer cells responsible for the growth of primary tumours are also able to re-initiate tumour growth after seeding to distant organs is unclear. The characterization of breast cancer cells with both of these attributes now identifies the functional and molecular determinants necessary to mediate primary tumour formation and re-initiation at the secondary site.
Abramson Family Cancer Research Institute, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.
Barzin Y
BY
Nabet
Abramson Family Cancer Research Institute, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA.
Andy J
AJ
Minn
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism*; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D007797:Laminin / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*
D014408:Biomarkers, Tumor; D007797:Laminin