Carbon Dioxide and Acetate-Free Biofiltration: A Relationship to be Investigated.
As the name reveals, acetate-free biofiltration (AFB) is featured by lack of acetate and this would seem to allow better hemodynamic stability. However, AFB also has a unique characteristic of carbon dioxide (CO2 )-free dialysate, whereas all other modern dialysis techniques imply an overload of CO2 from dialysate to the patient. This notwithstanding the role of CO2 in tolerance to dialysis treatment, both AFB and all other dialysis techniques seem not investigated in due depth. Specifically, the amount of CO2 coming back to the patient's bloodstream during AFB and bicarbonate dialysis (BD) is unknown. We measured partial pressure of CO2 (pCO2 ) in blood samples withdrawn from the venous line of the extracorporeal circuit during BD and subsequently during AFB in 22 stable chronic hemodialysis outpatients. The amount of CO2 coming back to the patient's bloodstream is higher in BD (59.1 ± 4.0 mmol/L) than in AFB (42.8 ± 4.5 mmol/L, P < 0.0001). Such difference exceeds 30%. Moreover, shifting from BD to AFB shows, notably for each patient, the reduction of pCO2 toward physiological values. BD implies CO2 overload from dialysate, whereas AFB does not. Further studies are required to evaluate if AFB would be the most appropriate dialysis technique in patients affected by chronic, but especially acute, lung diseases.
Hemodialysis Unit, Maria Rosaria Clinic, Pompeii, Napoli, Italy.
Marco
M
Marano
Hemodialysis Unit, Maria Rosaria Clinic, Pompeii, Napoli, Italy.
Anna
A
D'Amato
Hemodialysis Unit, Maria Rosaria Clinic, Pompeii, Napoli, Italy.
Alessandro
A
Patriarca
Nephrology & Dialysis Unit, San Felice a Cancello Hospital, San Felice a Cancello, Caserta, Italy.
Luigi Michele
LM
Di Nuzzi
Nephrology & Dialysis Unit, San Felice a Cancello Hospital, San Felice a Cancello, Caserta, Italy.
Gelsomina
G
Giordano
Nephrology & Dialysis Unit, San Felice a Cancello Hospital, San Felice a Cancello, Caserta, Italy.
Giuseppe
G
Iulianiello
D000368:Aged; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D017583:Hemodiafiltration / Q000009:adverse effects / Q000379:methods; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure
D002245:Carbon Dioxide; D010100:Oxygen
Acetate-free biofiltration; Bicarbonate dialysis; Carbon dioxide