Platelet interactions with viruses and parasites.
While the interactions between Gram-positive bacteria and platelets have been well characterized, there is a paucity of data on the interaction between other pathogens and platelets. However, thrombocytopenia is a common feature with many infections especially viral hemorrhagic fever. The little available data on these interactions indicate a similarity with bacteria-platelet interactions with receptors such as FcγRIIa and Toll-Like Receptors (TLR) playing key roles with many pathogens. This review summarizes the known interactions between platelets and pathogens such as viruses, fungi and parasites.
Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland , Dublin , Ireland.
Ana Lopez
AL
Alonso
Dermot
D
Cox
D000818:Animals; D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D010271:Parasites / Q000276:immunology*; D014780:Viruses / Q000276:immunology*
Fungi; parasites; platelets; viruses