Anthocephaline, a new indole alkaloid and cadambine, a potent inhibitor of DNA topoisomerase IB of Leishmania donovani (LdTOP1LS), isolated from Anthocephalus cadamba.
Chemical investigation of the stem bark of Anthocephalus cadamba has resulted in the isolation of anthocephaline (1), a new indole alkaloid, along with strictosamide (2), vincosamide (3) and cadambine (4). The structures of the isolated alkaloids (1-4) were established by detailed 2D NMR spectral analysis. Cadambine (4) exhibited potent DNA topoisomerase IB inhibitory activity.
Ashish
A
Kumar
Somenath Roy
SR
Chowdhury
Kumar Kalyan
KK
Jatte
Tulika
T
Chakrabarti
Hemanta K
HK
Majumder
Tarun
T
Jha
Sibabrata
S
Mukhopadhyay
D019295:Computational Biology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007893:Leishmania donovani / Q000201:enzymology*; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry*; D059004:Topoisomerase I Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000737:chemistry
D026121:Indole Alkaloids; D059004:Topoisomerase I Inhibitors; D014748:Vinca Alkaloids; C000598490:anthocephaline; C000598492:cadambine; C539462:strictosamide; C000598491:vincosamide