Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain.
Chordoid glioma of the third ventricle is a rare neuroepithelial tumor characterized by a unique histomorphology and exclusive association with the suprasellar/third ventricular compartment. Variously interpreted as either astrocytic- or ependymal-like, and speculatively ascribed to the lamina terminalis/subcommissural organ, its histogenesis remains, nevertheless, unsettled. Here, we report on a suprasellar chordoid glioma occurring in a 52-year-old man. Although displaying otherwise typical morphological features, the tumor was notable for expression of thyroid transcription factor 1, a marker of tumors of pituicytic origin in the context of the sellar region. We furthermore found overlapping immunoprofiles of this example of chordoid glioma and pituicytic tumors (pituicytoma and spindle cell oncocytoma), respectively. Specifically, phosphorylated ribosomal protein S6, a marker of mTOR pathway activation, was expressed in both groups. Based on these findings, we suggest that chordoid glioma and pituicytic tumors may form part of a spectrum of lineage-related neoplasms of the basal forebrain.
Institute of Pathology, University of Bern, 3010 Bern, Switzerland. Electronic address: ekkehard.hewer@pathology.unibe.ch.
Ekkehard
E
Hewer
Department of Neurosurgery, Inselspital, Bern University Hospital, and University of Bern, 3010 Bern, Switzerland.
Jürgen
J
Beck
Department of Neuroradiology, Inselspital, Bern University Hospital, and University of Bern, 3010 Bern, Switzerland.
Frauke
F
Kellner-Weldon
Institute of Pathology "Laenggasse", 3012 Bern, Switzerland.
Istvan
I
Vajtai
D018249:Adenoma, Oxyphilic / Q000737:chemistry* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D019070:Cell Lineage; D002551:Cerebral Ventricle Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D005910:Glioma / Q000737:chemistry* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis*; D010766:Phosphorylation; D010911:Pituitary Neoplasms / Q000737:chemistry* / Q000473:pathology; D011237:Predictive Value of Tests; D038601:Ribosomal Protein S6 / Q000032:analysis; D000074482:Thyroid Nuclear Factor 1; D046888:Tissue Array Analysis; D014157:Transcription Factors / Q000032:analysis*
D014408:Biomarkers, Tumor; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D038601:Ribosomal Protein S6; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors
Chordoid glioma of the third ventricle; Histogenesis; Mammalian target of rapamycin; Pituicytoma; Spindle cell oncocytoma of the adenohypophysis; Thyroid transcription factor 1