Interest of HYPR flow dynamic MRA for characterization of cerebral arteriovenous malformations: comparison with TRICKS MRA and catheter DSA.
OBJECTIVE
HYPR flow is a 3D dynamic contrast-enhanced MRA technique providing isotropic sub-millimetre resolution with half-second temporal resolution. We compared HYPR flow and time-resolved imaging of contrast kinetics (TRICKS) MRA for the characterization of cerebral arteriovenous malformations (cAVMs), using catheter DSA as reference.


METHODS
Twenty-two patients underwent HYPR flow and TRICKS MRA within 15 days of DSA. HYPR flow and TRICKS datasets were reviewed separately by two readers for image quality, Spetzler-Martin grade, venous ectasia, and deep venous drainage.


RESULTS
Image quality was better for HYPR flow than for TRICKS (narrower full width at half maximum; larger arterial diagnostic window; greater number of arterial frames, P ≤ 0.05). Using HYPR flow, inter-reader agreement was excellent for all cAVM characteristics. The agreement with DSA for the overall Spetzler-Martin grade was excellent for HYPR flow (ICC = 0.96 and 0.98, depending on the reader) and TRICKS (ICC = 0.82 and 0.95). In comparison to TRICKS, HYPR flow showed higher concordance with DSA for the identification of venous ectasia and deep venous drainage.


CONCLUSIONS
Owing to an excellent agreement with DSA with respect to depiction of the vascular architecture of cAVMs, HYPR flow could be useful for the non-invasive characterization of cAVMs.


CONCLUSIONS
• Dynamic MRA is used for cerebral AVM depiction and follow-up • HYPR flow is a new, highly-resolved dynamic MRA sequence • HYPR flow provides whole brain coverage • HYPR flow provides excellent agreement with the Spetzler-Martin grade • Compared to TRICKS MRA, HYPR flow improves cerebral AVM characterization.
Department of Radiology, Centre de Psychiatrie et Neuroscience, INSERM S894, Centre Hospitalier Sainte-Anne, Université Paris Descartes Sorbonne Paris Cité, DHU Neurovasc, 1 rue Cabanis, 75014, Paris, France.
Raphaël
R
Dautry
Department of Radiology, Centre de Psychiatrie et Neuroscience, INSERM S894, Centre Hospitalier Sainte-Anne, Université Paris Descartes Sorbonne Paris Cité, DHU Neurovasc, 1 rue Cabanis, 75014, Paris, France.
Myriam
M
Edjlali
Department of Radiology, Centre de Psychiatrie et Neuroscience, INSERM S894, Centre Hospitalier Sainte-Anne, Université Paris Descartes Sorbonne Paris Cité, DHU Neurovasc, 1 rue Cabanis, 75014, Paris, France.
Pauline
P
Roca
GE Healthcare, Vélizy-Villacoublay, France.
Cécile
C
Rabrait
Department of Medical Physics and Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Yijing
Y
Wu
Department of Medical Physics and Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Kevin
K
Johnson
Department of Medical Physics and Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Olivier
O
Wieben
Department of Radiology, Centre de Psychiatrie et Neuroscience, INSERM S894, Centre Hospitalier Sainte-Anne, Université Paris Descartes Sorbonne Paris Cité, DHU Neurovasc, 1 rue Cabanis, 75014, Paris, France.
Denis
D
Trystram
Department of Radiology, Centre de Psychiatrie et Neuroscience, INSERM S894, Centre Hospitalier Sainte-Anne, Université Paris Descartes Sorbonne Paris Cité, DHU Neurovasc, 1 rue Cabanis, 75014, Paris, France.
Christine
C
Rodriguez-Régent
Department of Radiology, Centre de Psychiatrie et Neuroscience, INSERM S894, Centre Hospitalier Sainte-Anne, Université Paris Descartes Sorbonne Paris Cité, DHU Neurovasc, 1 rue Cabanis, 75014, Paris, France.
Fawaz
F
Alshareef
Department of Medical Physics and Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Patrick
P
Turski
Department of Radiology, Centre de Psychiatrie et Neuroscience, INSERM S894, Centre Hospitalier Sainte-Anne, Université Paris Descartes Sorbonne Paris Cité, DHU Neurovasc, 1 rue Cabanis, 75014, Paris, France.
Jean-François
JF
Meder
Department of Radiology, Centre de Psychiatrie et Neuroscience, INSERM S894, Centre Hospitalier Sainte-Anne, Université Paris Descartes Sorbonne Paris Cité, DHU Neurovasc, 1 rue Cabanis, 75014, Paris, France.
Olivier
O
Naggara
Department of Radiology, Centre de Psychiatrie et Neuroscience, INSERM S894, Centre Hospitalier Sainte-Anne, Université Paris Descartes Sorbonne Paris Cité, DHU Neurovasc, 1 rue Cabanis, 75014, Paris, France. c.oppenheim@ch-sainte-anne.fr.
Catherine
C
Oppenheim
D000328:Adult; D015901:Angiography, Digital Subtraction / Q000379:methods; D002404:Catheterization / Q000379:methods; D002533:Cerebral Angiography / Q000379:methods; D003287:Contrast Media; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D002538:Intracranial Arteriovenous Malformations / Q000473:pathology* / Q000503:physiopathology; D007700:Kinetics; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055815:Young Adult
D003287:Contrast Media
Brain; Digital subtraction angiography; Intracranial arteriovenous malformations; Time-resolved contrast-enhanced magnetic resonance angiography