Copper-catalyzed aerobic oxidative amination of C(sp(3))-H bonds: synthesis of imidazo[1,5-a]pyridines.
Copper-catalyzed synthesis of imidazo[1,5-a]pyridine-1-carboxylates through oxidative amination of C(sp(3))-H bonds under mild aerobic conditions with broad substrate scope is described. Use of naturally abundant air as the sole oxidant was found to be efficient and selective. The present protocol is also applicable for direct synthesis of functionalized imidazo[1,5-a]pyridines from amino acid derivatives.
Academy of Scientific & Innovative Research, CSIR-Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar 364 002, Gujarat, India. adimurthy@csmcri.org.
Darapaneni Chandra
DC
Mohan
Sadu Nageswara
SN
Rao
Chitrakar
C
Ravi
Subbarayappa
S
Adimurthy