Neural underpinnings of the 'agent brain': new evidence from transcranial direct current stimulation.
Intentional binding (IB) refers to the temporal compression between a voluntary action and its sensory effect, and it is considered an implicit measure of sense of agency (SoA), that is, the capacity to control one's own actions. IB has been thoroughly studied from a behavioural point of view but only few studies have investigated its neural underpinnings, always using the same two paradigms. Although providing evidence that the supplementary motor complex is involved, findings are still too scarce to draw definitive conclusions. The aim of the present study was to establish a causal relationship between the pre-supplementary motor area (pre-SMA), known for its key role in action planning and initiation, and IB by means of transcranial direct current stimulation (tDCS). Participants underwent anodal, cathodal and sham control stimulations during three separate sessions (Experiment I). Subsequently, they underwent the same stimulation protocol (Experiment II) using as control a region potentially involved in the processing of the sensory effects of voluntary action (i.e., the right primary auditory cortex for the auditory effects of action). A significant reduction in IB was found only after stimulation of the pre-SMA, which supports the causal contribution of this prefrontal area in the perceived linkage between action and its effects. As SoA could be disrupted in many psychiatric and neurological diseases, these results have direct clinical relevance as tDCS could be successfully used in this domain in virtue of the promising advantages it offers for rehabilitation.
Department of General Psychology, University of Padova, Via Venezia 12, 35131, Padova, Italy.
Annachiara
A
Cavazzana
Department of General Psychology, University of Padova, Via Venezia 12, 35131, Padova, Italy.|Department of Life Sciences, University of Trieste, Trieste, Italy.
Barbara
B
Penolazzi
Department of General Psychology, University of Padova, Via Venezia 12, 35131, Padova, Italy.|Center for Cognitive Neuroscience, University of Padova, Padova, Italy.
Chiara
C
Begliomini
Department of General Psychology, University of Padova, Via Venezia 12, 35131, Padova, Italy.|Center for Cognitive Neuroscience, University of Padova, Padova, Italy.
Patrizia Silvia
PS
Bisiacchi
D000328:Adult; D001303:Auditory Cortex / Q000502:physiology; D005260:Female; D006801:Humans; D033182:Intention; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D020377:Self Efficacy; D065908:Transcranial Direct Current Stimulation; D055815:Young Adult
intentional binding; neural bases; pre-SMA; sense of agency; tDCS; voluntary action