[Expression of 5-lipoxygenase in human tissues and its association with disease].
5-Lipoxygenase, one of lipoxygenase isozymes, is a well-studied oxidative metabolism enzyme. It widely exists in various human tissues and cells, participates in the oxidative metabolism of endogenous and exogenous chemicals, and produces a variety of metabolites, all of which contribute to the occurrence of human diseases, such as inflammation, asthma, atherosclerosis, and tumor and so on. The expression of 5-lipoxygenase is at low level in normal human tissues while at high level in abnormal tissues. 5-Lipoxygenase is closely related to many kinds of diseases in human ovary, brain, cardiovascular system, lung, liver, pancreas and other tissues. The abnormal expression of 5-lipoxygenase tends to promote the development of the disease.
Department of Occupational and Environmental Health, School of Public Health, Central South University, Changsha 410078, China.
Shishu
S
Tang
Jian'an
J
Hu
D001094:Arachidonate 5-Lipoxygenase / Q000502:physiology*; D050197:Atherosclerosis / Q000201:enzymology; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology
D001094:Arachidonate 5-Lipoxygenase