[Renal late effects in patients treated for cancer in childhood].
Impaired renal function may occur following multimodal treatment of cancer in childhood. Renal late effects caused by chemotherapy, renal surgery and/or radiotherapy are now well described; but little is known about their prevalence and time of development. Herein, we provide a synthesis of the different renal complications that may occur with their physiopathology in relation with specific treatment exposures. This review summarized the literature that supported the recommendations issued by the long-term follow-up group of the "Société française des cancers de l'enfant (SFCE)" for childhood cancer survivors at risk for nephrotoxicity (www.sfce.org ; www.soc-nephrologie.org/SNP/index.htm). We developed these monitoring elements and the lifestyle recommendations for all asymptomatic survivors.
Centre Oscar-Lambret, unité d'oncologie pédiatrique, 3, rue Frederic-Combemale, 59000 Lille, France. Electronic address: h-sudour@o-lambret.fr.
Hélène
H
Sudour-Bonnange
CHU Nord Amiens, Département de Pédiatrie, 80000 Amiens, France.
Audrey
A
Vanrenterghem
CHU de Besançon, service de pédiatrie, réanimation-néphrologie infantile, 25000 Besançon, France.
François
F
Nobili
Hôpital de la Mère et de l'Enfant, Département de pédiatrie, 87000 Limoges, France.
Vincent
V
Guigonis
CHU Nord Amiens, Département de Pédiatrie, 80000 Amiens, France.
Bernard
B
Boudailliez
D000970:Antineoplastic Agents / Q000009:adverse effects*; D058070:Asymptomatic Diseases; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D016190:Carboplatin / Q000009:adverse effects; D002648:Child; D002945:Cisplatin / Q000009:adverse effects; D003131:Combined Modality Therapy / Q000009:adverse effects; D005919:Glomerular Filtration Rate; D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology; D007069:Ifosfamide / Q000009:adverse effects; D007668:Kidney / Q000002:abnormalities / Q000187:drug effects / Q000528:radiation effects; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control*; D008727:Methotrexate / Q000009:adverse effects; D009369:Neoplasms / Q000628:therapy*; D009392:Nephrectomy / Q000009:adverse effects; D011832:Radiation Injuries / Q000150:complications; D012307:Risk Factors; D017741:Survivors
D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin; D007069:Ifosfamide; D008727:Methotrexate
Chimiothérapie néphrotoxique; Dysfonction tubulaire et glomérulaire; HTA; Hypertension; Insuffisance rénale; Nephrectomy; Nephrotoxic chemotherapy; Néphrectomie; Radiothérapie rénale; Renal insufficiency; Renal radiotherapy; Tubular and glomerular dysfunction