Childhood trauma, midbrain activation and psychotic symptoms in borderline personality disorder.
Childhood trauma is believed to contribute to the development of borderline personality disorder (BPD), however the mechanism by which childhood trauma increases risk for specific symptoms of the disorder is not well understood. Here, we explore the relationship between childhood trauma, brain activation in response to emotional stimuli and psychotic symptoms in BPD. Twenty individuals with a diagnosis of BPD and 16 healthy controls were recruited to undergo a functional MRI scan, during which they viewed images of faces expressing the emotion of fear. Participants also completed the childhood trauma questionnaire (CTQ) and a structured clinical interview. Between-group differences in brain activation to fearful faces were limited to decreased activation in the BPD group in the right cuneus. However, within the BPD group, there was a significant positive correlation between physical abuse scores on the CTQ and BOLD signal in the midbrain, pulvinar and medial frontal gyrus to fearful (versus neutral) faces. In addition there was a significant correlation between midbrain activation and reported psychotic symptoms in the BPD group (P<0.05). These results show that physical abuse in childhood is, in individuals with BPD, associated with significantly increased activation of a network of brain regions including the midbrain in response to emotional stimuli. Sustained differences in the response of the midbrain to emotional stimuli in individuals with BPD who suffered childhood physical abuse may underlie the vulnerability of these patients to developing psychotic symptoms.
Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, UK.
K
K
Nicol
Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, UK.
M
M
Pope
Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, UK.
L
L
Romaniuk
1] Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, UK [2] Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK [3] MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
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Hall
D000328:Adult; D000069586:Adult Survivors of Child Adverse Events / Q000523:psychology*; D001883:Borderline Personality Disorder / Q000503:physiopathology / Q000523:psychology*; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D004644:Emotions; D005149:Facial Expression; D005239:Fear; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000503:physiopathology; D008875:Middle Aged; D009778:Occipital Lobe / Q000503:physiopathology; D011618:Psychotic Disorders / Q000503:physiopathology / Q000523:psychology*; D020649:Pulvinar / Q000503:physiopathology; D011795:Surveys and Questionnaires; D055815:Young Adult