Eunicellin-Based Diterpenoids, Hirsutalins S-V, from the Formosan Soft Coral Cladiella hirsuta.
Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/ CB-induced human neutrophils.
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. slime112229@gmail.com.
Tzu-Zin
TZ
Huang
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. a6152761@yahoo.com.tw.
Bo-Wei
BW
Chen
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. betty8575@yahoo.com.tw.
Chiung-Yao
CY
Huang
Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.|Department of Cosmetic Science and Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
Tsong-Long
TL
Hwang
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. uvaranichem@gmail.com.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. uvaranichem@gmail.com.
Chokkalingam
C
Uvarani
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan. corallab@ntu.edu.tw.
Chang-Feng
CF
Dai
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.|Department of Life Science and Institute of Biotechnology and Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
Ping-Jyun
PJ
Sung
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.|Department of Life Science and Institute of Biotechnology and Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan. x2219@nmmba.gov.tw.
Jui-Hsin
JH
Su
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.|Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.|Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. sheu@mail.nsysu.edu.tw.|Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan. sheu@mail.nsysu.edu.tw.|Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan. sheu@mail.nsysu.edu.tw.
Jyh-Horng
JH
Sheu
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D004224:Diterpenes; C476503:eunicellin; D013481:Superoxides; D010196:Pancreatic Elastase