V/P SPECT as a diagnostic tool for pregnant women with suspected pulmonary embolism.
OBJECTIVE
The purpose of the study was to assess the prevalence of pulmonary embolism (PE) and other lung diseases among pregnant women with suspected PE and to calculate the radiation exposure to patient and fetus in this population. As a secondary aim, we evaluated the negative predictive value of a normal ventilation/perfusion single photon emission computed tomography (V/P SPECT) examination in pregnancy.


METHODS
We studied all 127 pregnant women who had suspected PE and had undergone V/P SPECT at our institution in the course of a 5-year period. Radiation exposure to patient and fetus and the negative predictive value of a normal V/P SPECT examination were also measured.


RESULTS
V/P SPECT identified PE in 11 women (9%). Moreover, in 15 women (12%) the examination revealed pneumonia (in 2 cases in addition to PE) and in 1 woman signs of airway obstruction were revealed. Among the 116/127 women (91%) where PE was ruled out by V/P SPECT, none was diagnosed subsequently with PE or deep venous thrombosis (DVT) during the same pregnancy or puerperal period. For P SPECT, the calculated fetal absorbed dose was < 0.6 mGy,and the calculated breast absorbed dose 0.6 mGy. For V SPECT, the calculated fetal absorbed dose was < 0.014 mGy and the breast absorbed dose 0.25 mGy.


CONCLUSIONS
The prevalence of PE was low (9%) among pregnant women with suspected disease. Pneumonia was diagnosed in 12% of patients. The negative predictive value of V/P SPECT was high, and the radiation exposure from V/P SPECT was low both for fetus and patient.
Clinical Physiology and Nuclear Medicine, Skåne University Hospital and Lund University , 221 85, Lund, Sweden, marika.bajc@med.lu.se.
Marika
M
Bajc
Berit
B
Olsson
Anders
A
Gottsäter
Cecilia
C
Hindorf
Jonas
J
Jögi
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D055420:Perfusion Imaging; D011247:Pregnancy; D011248:Pregnancy Complications / Q000000981:diagnostic imaging*; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D015899:Tomography, Emission-Computed, Single-Photon
D019275:Radiopharmaceuticals