Diagnosed diabetes and premature death among middle-aged Japanese: results from a large-scale population-based cohort study in Japan (JPHC study).
OBJECTIVE
To examine the association between diabetes and premature death for Japanese general people.


METHODS
Prospective cohort study.


METHODS
The Japan Public Health Center-based prospective study (JPHC study), data collected between 1990 and 2010.


METHODS
A total of 46,017 men and 53,567 women, aged 40-69 years at the beginning of baseline survey.


METHODS
Overall and cause specific mortality. Cox proportional hazards models were used to calculate the HRs of all cause and cause specific mortality associated with diabetes.


RESULTS
The median follow-up period was 17.8 years. During the follow-up period, 8223 men and 4640 women have died. Diabetes was associated with increased risk of death (856 men and 345 women; HR 1.60, (95% CI 1.49 to 1.71) for men and 1.98 (95% CI 1.77 to 2.21) for women). As for the cause of death, diabetes was associated with increased risk of death by circulatory diseases (HR 1.76 (95% CI 1.53 to 2.02) for men and 2.49 (95% CI 2.06 to 3.01) for women) while its association with the risk of cancer death was moderate (HR 1.25 (95% CI 1.11 to 1.42) for men and 1.04 (95% CI 0.82 to 1.32) for women). Diabetes was also associated with increased risk of death for 'non-cancer, non-circulatory system disease' (HR 1.91 (95% CI 1.71 to 2.14) for men and 2.67 (95% CI 2.25 to 3.17) for women).


CONCLUSIONS
Diabetes was associated with increased risk of death, especially the risk of death by circulatory diseases.
Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan Fiore Kenshin Clinic, Tokyo, Japan.
Masayuki
M
Kato
Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
Mitsuhiko
M
Noda
Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Tetsuya
T
Mizoue
Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan Department of Public Health, Tokyo Women's Medical University, Tokyo, Japan.
Atsushi
A
Goto
Division of Diabetes and Metabolism, Iwate Medical University School of Medicine, Morioka, Japan.
Yoshihiko
Y
Takahashi
Department of Clinical Research, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Yumi
Y
Matsushita
Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
Akiko
A
Nanri
Department of Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, Osaka-fu, Japan.
Hiroyasu
H
Iso
Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Manami
M
Inoue
Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Norie
N
Sawada
Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
Shoichiro
S
Tsugane
D000328:Adult; D000368:Aged; D002423:Cause of Death; D003920:Diabetes Mellitus / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D061213:Mortality, Premature; D011446:Prospective Studies; D057566:Self Report
DIABETES & ENDOCRINOLOGY; EPIDEMIOLOGY