C-reactive protein level as a possible predictor for early postoperative ileus following elective surgery for colorectal cancer.
OBJECTIVE
Inflammatory reactions are par- tially responsible for postoperative ileus (POI). Serum C-reactive protein (CRP) is an acknowledged marker of inflammation. In this study the CRP response with respect to POI in elective colorectal surgery was exam- ined to define the role of serum CRP as an early predic- tor of POI.


METHODS
Three hundred eighty-three patients who underwent elective colorectal resection were identified for inclusion in this study. We defined early POI as that occurring within 30 days following the surgery. Thirty-five patients with POI were com- pared to a subgroup of 348 patients with an unevent- ful postoperative course, and the correlation between postoperative serum CRP levels and POI in colorectal surgery was investigated.


RESULTS
In the univariate analysis, length of operation, surgical blood loss, and serum CRP were factors significantly associated with POI following colorectal surgery; however, these fac- tors lost their significance on multivariate analysis.


CONCLUSIONS
Our results suggest that an increase in CRP levels alone is not a predictor for POI following surgery for colorectal surgery. Although inflammatory responses are known to contribute to the ileus, ad- ditional study is required to identify risk factors that would be more useful for prediction of POI.
Takaaki
T
Fujii
Toshinaga
T
Sutoh
Wakako
W
Kigure
Hiroki
H
Morita
Toshihide
T
Katoh
Reina
R
Yajima
Soichi
S
Tsutsumi
Takayuki
T
Asao
Hiroyuki
H
Kuwano
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016063:Blood Loss, Surgical; D002097:C-Reactive Protein / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000473:pathology / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D045823:Ileus / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D061646:Operative Time; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein