Ameloblastoma: a clinical review and trends in management.
Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.
Department of Pathology, Stanford University, 300 Pasteur Drive, Lane 235, Stanford, CA, 94305-5324, USA. amcclary@stanford.edu.
Andrew C
AC
McClary
Department of Pathology, Stanford University, 300 Pasteur Drive, Lane 235, Stanford, CA, 94305-5324, USA.
Robert B
RB
West
Department of Pediatrics, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
Ashley C
AC
McClary
Department of Pathology, Stanford University, 300 Pasteur Drive, Lane 235, Stanford, CA, 94305-5324, USA.
Jonathan R
JR
Pollack
Department of Radiology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
Nancy J
NJ
Fischbein
Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University, 801 Welch Rd., MC 5739, Stanford, CA, 94305, USA.
Christopher F
CF
Holsinger
Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University, 801 Welch Rd., MC 5739, Stanford, CA, 94305, USA.
John
J
Sunwoo
Division of Oncology, Department of Medicine, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
A Dimitrios
AD
Colevas
Division of Head and Neck Surgery, Department of Otolaryngology, Stanford University, 801 Welch Rd., MC 5739, Stanford, CA, 94305, USA. dsirjani@ohns.stanford.edu.
Davud
D
Sirjani
D000564:Ameloblastoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D019468:Disease Management; D006801:Humans; D007573:Jaw Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology; D008339:Mandibular Neoplasms / Q000473:pathology; D008437:Maxilla / Q000000981:diagnostic imaging / Q000473:pathology; D019647:Oral Surgical Procedures / Q000379:methods*; D011379:Prognosis; D019651:Plastic Surgery Procedures / Q000379:methods*
Ameloblastoma; BRAF; Clinical review; Genomics; Head and neck surgery; Personalized medicine; SHH