[Clinical significances of plasma interleukin-6,C-reaction protein and tumor necrosis factor-alpha in patients with aortic dissection].
OBJECTIVE
To investigate the clinical significances of plasma IL-6, CRP and TNF-alpha concentration changes in aortic dissection.


METHODS
Plasma concentrations of IL-6, TNF-alpha and CRP were determined in 68 aortic dissection patients,50 patients with essential hypertensionand 50 healthy volunteers. The changes of plasma IL-6, CRP and TNF-alpha concentration were analyzed in aortic group along with the progression of the disease which was divided into 9 differenttime courses.


RESULTS
Compared with essential hypertension and healthy control group, significantly elevated CRP, IL-6 and TNF-alpha concentrations were detected in aortic dissection patients (P<0.05, respectively). All the concentrations of CRP, IL-6 and TNF-alpha reached the peak in acute phase of aortic dissection and then gradually declined in subacute and chronic phase.


CONCLUSIONS
Increased plasma inflammatory factors were significantly associated with aortic dissection.
Ming-hua
MH
Zhong
Jun
J
Gu
Er-yong
EY
Zhang
D017545:Aortic Aneurysm, Thoracic / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein