[Diagnostic value of IgG subtypes in membranous nephropathy: A case report].
The study of immunoglobulin G subtypes constituting immune deposits present in membranous nephropathy is useful to guide diagnosis. IgG4 deposits are more often seen in primitive forms of membranous nephropathy due to autoantibody (anti-phospholipase A2 receptor in a majority of cases). These deposits are polytypic. In secondary forms, deposits are constituted of IgG1, IgG2 and IgG3. We report the case of a 52-year-old woman whose renal biopsy, done for glomerular proteinuria, shows membranous nephropathy with monotypic IgG4 deposits with no overt hematologic malignancy and no anti-PLA2R antibodies.
Laboratoire d'anatomie pathologique, université René-Descartes, hôpital Necker, 75015 Paris, France.
Safaa
S
Asmandar
Laboratoire d'anatomie pathologique, université René-Descartes, hôpital Necker, 75015 Paris, France.
Marie-Lucile
ML
Figuères
Laboratoire d'anatomie pathologique, université de Poitiers, 86000 Poitiers, France.
Jean-Michel
JM
Goujon
Laboratoire d'anatomie pathologique, université René-Descartes, hôpital Necker, 75015 Paris, France.
Laure-Hélène
LH
Noël
Pôle de néphrologie et de transplantation, université René-Descartes, hôpital Necker, 75015 Paris, France. Electronic address: aurelie.hummel@nck.aphp.fr.
Aurélie
A
Hummel
D000328:Adult; D001323:Autoantibodies / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D007678:Kidney Glomerulus / Q000276:immunology / Q000378:metabolism; D054507:Receptors, Phospholipase A2 / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G; C516360:PLA2R1 protein, human; D054507:Receptors, Phospholipase A2
Gammapathie monoclonale de signification rénale; Glomérulonéphrite extramembraneuse; IgG4; IgG4 monotypique; Immunoglobulin G subtypes; Membranous nephropathy; Monoclonal gammapathy of renal significance; Sous-type d’immunoglobuline G