Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.
Seven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A-D (3a, 3c, 4a, 4c), together with seven known compounds (5-11) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by extensive 1D and 2D NMR and mass spectrometric data. All the compounds were evaluated for their potential inhibitory activity against eight different protein kinases involved in cell proliferation, cancer, diabetes and neurodegenerative disorders as well as for their antioxidant and antibacterial activities.
Laboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France. hefei@scsio.ac.cn.
Fei
F
He
Laboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France. mhoanglinh@yahoo.fr.
Linh H
LH
Mai
Laboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France. longeon@mnhn.fr.
Arlette
A
Longeon
School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. b.copp@auckland.ac.nz.
Brent R
BR
Copp
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, France. Nadege.Loaec@univ-brest.fr.
Nadège
N
Loaëc
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, France. amandine.bescond@sb-roscoff.fr.
Amandine
A
Bescond
ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, France. meijer@manros-therapeutics.com.
Laurent
L
Meijer
Laboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France. bourguet@mnhn.fr.
Marie-Lise
ML
Bourguet-Kondracki
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D011494:Protein Kinases / Q000737:chemistry; D047131:Xestospongia / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D009285:Naphthoquinones; D011494:Protein Kinases