Glycemic changes after gastrectomy in non-morbidly obese patients with gastric cancer and diabetes.
OBJECTIVE
To evaluate the glycemic changes after gastrectomy in non-morbidly obese patients with gastric cancer (GC) and type 2 diabetes mellitus (T2DM).


METHODS
Between December 2011 and June 2014, we included 46 patients with gastric cancer and T2DM of a body mass index (BMI) < 30 kg/m2, who underwent gastrectomy in our center. The comparisons of FPGs in specific periods were performed according to age, extent of gastrectomy, reconstruction type, preoperative triglyceride (TG) level and so on.


RESULTS
The non-morbidly obese patients experienced an improvement of glycemic control. T2DM resolution happened 3 weeks after surgery. FPG decreased significantly after postoperative day 21 compared to preoperative FPG. 32 patients experienced DM improvement after postoperative day 21. The age and relatively lower preoperative TG patients, who underwent total gastrectomy (P<0.001) or duodenal bypass reconstruction (Billroth II, Roux-en-Y gastrojejunostomy, or Roux-en-Y esophagojejunostomy, P=0.009) appeared to have a better glycemic control.


CONCLUSIONS
Our finding observed through this simulation model suggested that non-morbidly obese patients may also benefit from metabolic surgery for glycemic control, associated with age, extent of gastrectomy, reconstruction type, and preoperative triglyceride level.
Zhiyong
Z
Shen
Jiang
J
Yu
Shangtong
S
Lei
Tingyu
T
Mou
Yanfeng
Y
Hu
Hao
H
Liu
Guoxin
G
Li
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000713:Anastomosis, Roux-en-Y; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D004946:Esophagostomy; D005215:Fasting / Q000097:blood; D005260:Female; D005743:Gastrectomy; D005763:Gastroenterostomy; D006801:Humans; D007582:Jejunostomy; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000175:diagnosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D014280:Triglycerides