Effects of Cydonia oblonga Miller leaf and fruit flavonoids on blood lipids and anti-oxydant potential in hyperlipidemia rats.
OBJECTIVE
To study the effects of Cydonia oblonga Miller (COM) total flavonoids (TF) from leaves and fruit on the blood lipid and antioxidant potentials using hyperlipidaemic rat models.


METHODS
Hyperlipidaemic rat models were created with high-lipid emulsion. Rats were distributed into normal controls, hyperlipidaemic models, and daily high (160mg/kg), medium (80mg/kg) and low (40mg/kg) TF from leaves and fruit and simvastatin (5mg/kg) groups. After four weeks, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), as well as hepatic superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were measured.


RESULTS
Compared with the hyperlipidaemic model group, TF significantly reduced serum TC, TG, LDL-C (P<0.01), ALT and AST (P<0.01 or P<0.05) and increased HDL-C (P<0.05 or P<0.01). TF also reduced MDA (P<0.01 or P<0.01).


CONCLUSIONS
COM total flavonoids can effectively regulate the metabolism of lipids, and remove oxygen free radicals. This confirms its potential value in the prevention and treatment of hyperlipidaemia.
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China; Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France. Electronic address: Anwar.umar@126.com.
Anwar
A
Umar
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China.
Guldiyar
G
Iskandar
Department of Drug Analysis, Xinjiang Medical University, 830011 Urumqi, PR China.
Ainiwaer
A
Aikemu
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China.
Wuliya
W
Yiming
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China.
Wenting
W
Zhou
Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France.
Bénedicte
B
Berké
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China; Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France.
Bernard
B
Begaud
Department of Pharmacology, Xinjiang Medical University, 830011 Urumqi, PR China; Department of Pharmacology - Université Bordeaux Segalen, F-33076 Bordeaux, France; Department of Drug Analysis, Xinjiang Medical University, 830011 Urumqi, PR China. Electronic address: nicholas.moore@pharmaco.u-bordeaux2.fr.
Nicholas
N
Moore
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D002784:Cholesterol / Q000097:blood; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005638:Fruit / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D027824:Rosaceae / Q000737:chemistry*; D019821:Simvastatin / Q000494:pharmacology / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D005419:Flavonoids; D008055:Lipids; D010936:Plant Extracts; D008315:Malondialdehyde; D002784:Cholesterol; D019821:Simvastatin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Antioxidant effect; Blood lipids; Cydonia oblonga miller; Hyperlipidemic rats; Oxygen free radicals