A new cycloartane glucoside from Rhizophora stylosa.
Nine secondary metabolites, including a new cycloartane glucoside, rhizostyloside (1), were isolated from a methanol extract of Rhizophora stylosa leaves through several chromatographic experiments. The structures of the compounds were determined on the basis of NMR spectroscopic (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY) and HR-ESI-MS data and by comparison with literature values. Compound 1 exhibited significant cytotoxicity against three human cancer cell lines: KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), and SK-Mel-2 (melanoma). In addition, 1 strongly activated caspase-3/7 in LU-1 cells.
Phan Thi Thanh
PT
Huong
Chau Ngoc
CN
Diep
Nguyen Van
NV
Thanh
Vu Anh
VA
Tu
Tran Hong
TH
Hanh
Nguyen The
NT
Cuong
Nguyen Phuong
NP
Thao
Nguyen Xuan
NX
Cuong
Do Thi
do T
Thao
Tran Huy
TH
Thai
Nguyen Hoai
NH
Nam
Ninh Khac
NK
Ban
Phan Van
PV
Kiem
Chau Van
CV
Minh
D053148:Caspase 3 / Q000235:genetics / Q000378:metabolism; D053179:Caspase 7 / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification; D043982:Rhizophoraceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
D005960:Glucosides; D010936:Plant Extracts; D014315:Triterpenes; C085352:cycloartane; D053148:Caspase 3; D053179:Caspase 7