Pain-associated biomarkers in breast cancer.
Breast cancer represents a major public health problem, being the highest incidence neoplasia in females in Romania. The most important step in the treatment of this neoplasia is the surgical procedure; the biggest problem associated with this form of treatment in these patients is pain-related. Pain is a complex symptom with an impact on quality of life and psychology of cancer patient and can only be monitored verbally and subjectively. Consequently, the purpose of our work is to identify some biochemical parameters involved in the events cascade associated with inflammation and pain in breast cancer female patients, monitored in dynamics of anesthesia and surgical procedure. Measurements of lipid peroxides, ceruloplasmin and immune circulating complexes in mentioned dynamics have been performed. The recorded values are in concordance with the inflammatory processes and pain intensity, thus we can allege that these measurements can complete the pain-associated clinical picture in female breast cancer patients.
Anaesthesia and Intensive Care Unit, Oncological Institute Bucharest, Romania.
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Diaconu
Anaesthesia and Intensive Care Unit, Oncological Institute Bucharest, Romania.
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Pantis
1st Department of General Surgery, "Carol Davila" University of Medicine and Pharmacy, Oncological Institute Bucharest, Romania.
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Cirimbei
2nd Department of General Surgery, "Carol Davila" University of Medicine and Pharmacy, Oncological Institute Bucharest, Romania.
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Bordea
Biochemistry and Radiobiology Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
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Gruia
2nd Department of General Surgery, "Carol Davila" University of Medicine and Pharmacy, Oncological Institute Bucharest, Romania.
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Blidaru
D000368:Aged; D000758:Anesthesia; D000936:Antigen-Antibody Complex / Q000097:blood; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism* / Q000601:surgery; D002570:Ceruloplasmin / Q000378:metabolism; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D008875:Middle Aged; D010146:Pain / Q000209:etiology*
D000936:Antigen-Antibody Complex; D014408:Biomarkers, Tumor; D008054:Lipid Peroxides; D002570:Ceruloplasmin
breast cancer; ceruloplasmin; immune circulating complexes; lipid peroxides; pain cancer