Baculovirus-mediated gene delivery and RNAi applications.
Baculoviruses are widely encountered in nature and a great deal of data is available about their safety and biology. Recently, these versatile, insect-specific viruses have demonstrated their usefulness in various biotechnological applications including protein production and gene transfer. Multiple in vitro and in vivo studies exist and support their use as gene delivery vehicles in vertebrate cells. Recently, baculoviruses have also demonstrated high potential in RNAi applications in which several advantages of the virus make it a promising tool for RNA gene transfer with high safety and wide tropism.
Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Eastern Finland, Kuopio 70211 Finland. Emilia.Makkonen@uef.fi.
Kaisa-Emilia
KE
Makkonen
Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Eastern Finland, Kuopio 70211 Finland. Kari.Airenne@uef.fi.
Kari
K
Airenne
Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Eastern Finland, Kuopio 70211 Finland. Seppo.YlaHerttuala@uef.fi.|Gene Therapy Unit, Kuopio University Hospital, Kuopio 70211, Finland. Seppo.YlaHerttuala@uef.fi.|Science Service Center, Kuopio University Hospital, Kuopio 70211, Finland. Seppo.YlaHerttuala@uef.fi.
Seppo
S
Ylä-Herttulala
D000818:Animals; D001181:Arthropods; D016367:Baculoviridae / Q000235:genetics* / Q000502:physiology; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D034622:RNA Interference; D014161:Transduction, Genetic; D014714:Vertebrates