Impact of maternal obesity on fetal programming of cardiovascular disease.
The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to maternal consequences of obesity during pregnancy and the subsequent impact on fetal cardiovascular development.
Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and robertsv@ohsu.edu.
Victoria H J
VH
Roberts
Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon.
Antonio E
AE
Frias
Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, Oregon; and.
Kevin L
KL
Grove
D000818:Animals; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000196:embryology / Q000453:epidemiology* / Q000503:physiopathology; D002319:Cardiovascular System / Q000196:embryology / Q000503:physiopathology; D058872:Epidemics; D005260:Female; D005318:Fetal Heart / Q000503:physiopathology; D006801:Humans; D039382:Maternal Nutritional Physiological Phenomena; D009765:Obesity / Q000175:diagnosis / Q000196:embryology / Q000453:epidemiology* / Q000503:physiopathology; D038081:Organogenesis; D010920:Placenta / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011379:Prognosis; D012307:Risk Factors