Post-stroke memory impairment among patients with vascular mild cognitive impairment.
BACKGROUND
The American Stroke Association/American Heart Association recommended the criteria for diagnosis of vascular cognitive impairment and memory impairment (MI) is a feature in the classification of vascular mild cognitive impairment (VaMCI). VaMCI patients with MI may differ in terms of infarct location or demographic features, so we evaluated the clinical characteristics associated with MI in patients with VaMCI.


METHODS
A prospective multicenter study enrolled 353 acute ischemic stroke patients who underwent evaluation using the Korean Vascular Cognitive Impairment Harmonization Standard Neuropsychological Protocol at three months after onset. The association between MI and demographic features, stroke risk factors, and infarct location was assessed.


RESULTS
VaMCI was diagnosed in 141 patients, and 58 (41.1%) exhibited MI. Proportions of men and of left side infarcts were higher in VaMCI with MI than those without (75.9 vs. 57.8%, P = 0.03, 66.7 vs. 47%, P = 0.02). Multiple logistic analyses revealed that male sex (odds ratio [OR] 3.07, 95% confidence interval [95% CI] 1.12-8.42), left-side infarcts (OR 3.14, 95% CI 1.37-7.20), and basal ganglia/internal capsule infarcts (OR 4.53, 95% CI 1.55-13.22) were associated with MI after adjusting other demographic variables, vascular risk factors, and subtypes of stroke.


CONCLUSIONS
MI is associated with sex and infarct location in VaMCI patients.
Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, South Korea. dowonc@naver.com.
Soo-Jin
SJ
Cho
Department of Neurology, Hallym University College of Medicine, Anyang, South Korea. ykh1030@hallym.or.kr.
Kyung-Ho
KH
Yu
Department of Neurology, Hallym University College of Medicine, Anyang, South Korea. iyyar@hallym.or.kr.
Mi Sun
MS
Oh
Department of Neurology, Hallym University College of Medicine, Anyang, South Korea. neurojs@hallym.ac.kr.
San
S
Jung
Department of Neurology, Hallym University College of Medicine, Anyang, South Korea. leeforte@medimail.co.kr.
Ju-Hun
JH
Lee
Department of Neurology, National Medical Center, Seoul, South Korea. neukoh@naver.com.
Im-Seok
IS
Koh
Department of Neurology, Stroke Center, Seoul National University Bundang Hospital, Sungnam, South Korea. braindoc@snu.ac.kr.
Hee-Joon
HJ
Bae
Department of Psychology, Hallym University, Chuncheon, South Korea. ykang913@gmail.com.
Yeonwook
Y
Kang
Department of Neurology, Hallym University College of Medicine, Anyang, South Korea. ssbrain@hallym.ac.kr.
Byung-Chul
BC
Lee
D000368:Aged; D020144:Basal Ganglia Cerebrovascular Disease / Q000150:complications / Q000523:psychology*; D020520:Brain Infarction / Q000150:complications / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000209:etiology / Q000523:psychology*; D015331:Cohort Studies; D015140:Dementia, Vascular / Q000209:etiology / Q000523:psychology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000523:psychology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000150:complications / Q000523:psychology; D014481:United States