Conservative treatment and percutaneous catheter drainage improve outcome of necrotizing pancreatitis.
OBJECTIVE
To investigate the clinical effects of the maximum conservative treatment algorithm with percutaneous catheter drainage (PCD) as the first choice for necrotizing pancreatitis (NP).


METHODS
Retrospectively analyzed NP patients who had fine needle aspiration (FNA) for proven infection of necrosis which was considered an indication for surgery (n=22, group 1) compared to patients subjected to maximum conservative treatment with PCD in NP patients (n=30, group 2).


RESULTS
On admission, most baseline data did not show any statistical difference between the two groups, In group 2, all patients were implemented maximum conservative treatment, 25 of 30 patients were cured by PCD (83.3%), open necrosectomy were needed for 3 patients (10.0%) and 2 dead during hospitalization (6.7%). Whereas, in group 1, surgical operation rate was 45.6% and hospital mortality 31.8%, both of the ratios differed significantly compared with group 2 (45.6% vs. 10%, P=0.004; 31.8% vs. 6.7%, P=0.046 respectively). Furthemore, Hospital stay were significantly higher in group 1 compared with group 2 (90±18.5 vs. 39±13.4; P=0.033).


CONCLUSIONS
A conservative approach with PCD as the first choice to treatment NP might decrease the rate of surgical operation and mortality, and improve the outcome of NP.
Junjun
J
Sun
Cheng
C
Yang
Weifeng
W
Liu
Yanhui
Y
Yang
Shifang
S
Qi
Zhijie
Z
Chu
Shiyong
S
Xin
Xiaohui
X
Zhang
D000328:Adult; D000465:Algorithms; D044963:Biopsy, Fine-Needle; D002404:Catheterization / Q000009:adverse effects / Q000401:mortality; D002681:China; D019091:Critical Pathways; D004322:Drainage / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D019283:Pancreatitis, Acute Necrotizing / Q000175:diagnosis / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D011446:Prospective Studies; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome