Cocrystal Formation through Mechanochemistry: from Neat and Liquid-Assisted Grinding to Polymer-Assisted Grinding.
Mechanochemistry is an effective method for the preparation of multicomponent crystal systems. In the present work, we propose an alternative to the established liquid-assisted grinding (LAG) approach. Polymer-assisted grinding (POLAG) is demonstrated to provide a new class of catalysts for improving reaction rate and increasing product diversity during mechanochemical cocrystallization reactions. We demonstrate that POLAG provides advantages comparable to the conventional liquid-assisted process, whilst eliminating the risk of unwanted solvate formation as well as enabling control of resulting particle size. It represents a new approach for the development of functional materials through mechanochemistry, and possibly opens new routes toward the understanding of the mechanisms and pathways of mechanochemical cocrystal formation.
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK).|Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa 1, 34127, Trieste (Italy).
Dritan
D
Hasa
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK).|CAPES Foundation, Ministry of Education of Brazil, Brasilia - DF 70040-020 (Brazil).
Gabriela Schneider
GS
Rauber
Department of Chemical and Pharmaceutical Sciences, University of Trieste, P.le Europa 1, 34127, Trieste (Italy).
Dario
D
Voinovich
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK). wj10@cam.ac.uk.
William
W
Jones
cocrystals; mechanochemistry; polymers; polymorphism; solid-state reactions