A potential mechanism for extracellular matrix induction of breast cancer cell normality.
Extracellular matrix proteins from embryonic mesenchyme have a normalizing effect on cancer cells in vitro and slow tumor growth in vivo. This concept is suggestive of a new method for controlling the growth and spread of existing cancer cells in situ and indicates the possibility that extracellular proteins and/or embryonic mesenchymal fibroblasts may represent a fertile subject for study of new anti-cancer treatments.
School of Medical Diagnostic and Translational Sciences, College of Health Sciences, Old Dominion University, Norfolk, VA, 23529, USA. rbruno@odu.edu.
Robert D
RD
Bruno
Mammary Stem Cell Biology Section, CCBB, Center for Cancer Research, NCI, Bethesda, MD, 20892, USA. smithg@mail.nih.gov.
Gilbert H
GH
Smith
D000818:Animals; D058578:Biglycan / Q000737:chemistry*; D001943:Breast Neoplasms / Q000473:pathology*; D018929:Cell Culture Techniques; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000196:embryology*; D008648:Mesoderm / Q000473:pathology*
D058578:Biglycan