Synthesis of multiply substituted 1,6-dihydropyridines through Cu(I)-catalyzed 6-endo cyclization.
Copper-catalyzed 6-endo cyclization of N-propargylic β-enaminocarbonyls was developed for the synthesis of oxidation-labile 1,6-dihydropyridines. This synthetic method allows flexible and regio-defined assembly of various substituents at the N1, C2, C3, C4, and C6 positions of 1,6-dihydropyridines under mild conditions.
Division of Chemistry, Graduate School of Science, Hokkaido University, N10 W8, Sapporo 060-0810, Japan. oguri@sci.hokudai.ac.jp.
Haruki
H
Mizoguchi
Ryo
R
Watanabe
Shintaro
S
Minami
Hideaki
H
Oikawa
Hiroki
H
Oguri
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction
D004095:Dihydropyridines; D003300:Copper