A review of collagen cross-linking in cornea and sclera.
Riboflavin/UVA cross-linking is a technique introduced in the past decades for the treatment of keratoconus, keratectasia, and infectious keratitis. Its efficacy and safety have been investigated with clinical and laboratory studies since its first clinical application by Wollensak for the treatment of keratoconus. Although its complications are encountered during clinical practice, such as infection inducing risk, minimal invasion merits a further investigation on its future application in clinical practice. Recently, collagen cross-linking in sclera shows a promising prospect. In present study, we summarized the representative studies describing the clinical and laboratory application of collagen cross-linking published in past decades and provided our opinion on the positive and negative results of cross-linking in the treatment of ophthalmic disorders.
Department of Ophthalmology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250000, China.
Xiao
X
Zhang
Department of Ophthalmology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250000, China.
Xiang-Chen
XC
Tao
Zibo Eye Hospital, No. 33-6, Songlingxi Street, Zichuan, Zibo, Shandong 255100, China.
Jian
J
Zhang
Department of Ophthalmology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250000, China.
Zhi-Wei
ZW
Li
Department of Ophthalmology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250000, China.
Yan-Yun
YY
Xu
Department of Ophthalmology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250000, China.
Yu-Meng
YM
Wang
Department of Ophthalmology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250000, China.
Chun-Xiao
CX
Zhang
Department of Ophthalmology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250000, China.
Guo-Ying
GY
Mu