[Role of syndecan-2 in amyloid plaque formation].
The famous phrase of F. Engels "Life is the mode of existence of protein bodies", has deeply insinuated itself in our mind. However at a more profound insight, the form of protein bodies is associaited not only with the fact of their existence, but also with the time changes. What unites all of us in our oldage? The answer is clear: it is the change in the way of existence of protein molecules, and more precisely, their uncontrolled aggregation that can take place in any organ and be associated with any protein. In spite of different clinical presentations, all diseases associated with pathological accumulation of aggregated proteins are combined in a general group called amyloisosis. Depen- dent on the place of formation, it is possible to distinguish an infinite number of pathologies from neurodegen- erative and oncologic ones to arthritis and tuberculosis. There is no doubt that provided all clandestine mechanisms are clarified at which an absolutely normal functioning.protein can transform into a pathological aggregated form, it will give us a chance to prevent protein aggregation and create a new form of drugs for prolongation of life. In this review we considered the function of syndecan-2, the structure of syndecan-2 and its role in the formation of amyloid plaques.
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Leonova
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Galzitskaia
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000595:Amino Acid Sequence / Q000235:genetics; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000818:Animals; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D019812:Heparan Sulfate Proteoglycans / Q000737:chemistry / Q000235:genetics; D006801:Humans; D058225:Plaque, Amyloid / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D066263:Protein Aggregation, Pathological / Q000235:genetics* / Q000378:metabolism; D053669:Syndecan-2 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D016229:Amyloid beta-Peptides; D019812:Heparan Sulfate Proteoglycans; C508245:SDC2 protein, human; D053669:Syndecan-2