Serum adropin level in patients with stable coronary artery disease.
OBJECTIVE
Adropin is a newly identified secreted protein implicated in the regulation of insulin sensitivity and vascular endothelial function. Recent studies have shown that lower serum adropin level is related to acute myocardial infarction and coronary atherosclerosis. The primary objective of this study was to ascertain the association of serum adropin level with stable coronary artery disease (SCAD).


METHODS
We prospectively recruited a cohort of patients with SCAD and similar sample size subjects without coronary artery disease as controls. Their serum adropin levels were measured, and the severity of coronary atherosclerosis in SCAD patients was quantified with the syntax score.


RESULTS
A total of 116 patients with SCAD and 116 control subjects without coronary artery disease were recruited. Patients with SCAD had lower serum adropin levels when compared with the controls (59.2±19.3 versus 70.0±18.2 pg/mL, P<0.001). The multiple logistic regression revealed that low serum adropin level was a significant predictor of SCAD (AOR 0.976, 95% CI 0.960-0.992; p=0.003). Through the gamma regression model, it was further revealed that serum adropin level is significantly associated with syntax score (coefficient: -0.134, 95% CI: -0.212- -0.056; p=0.001).


CONCLUSIONS
Low serum adropin level is a significant predictor of SCAD. It is also associated with syntax score, thus indicating the close relationship between adropin and coronary atherosclerosis.
Department of Cardiology, The First Affiliated Hospital of Soochow University, PR China; Department of Cardiology, The Second Affiliated Hospital of Soochow University, PR China.
Liang-Ping
LP
Zhao
Department of Cardiology, The Second Affiliated Hospital of Soochow University, PR China.
Wei-Ting
WT
Xu
Department of Cardiology, The Second Affiliated Hospital of Soochow University, PR China.
Li
L
Wang
Department of Cardiology, The Second Affiliated Hospital of Soochow University, PR China.
Tao
T
You
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore; Cardiovscular Research Institute, National University Heart Centre Singapore, National University Health System, Republic of Singapore; Department of Mathematics & Statistics, Faculty of Science, Technology & Engineering, La Trobe University, Melbourne, Vic, Australia.
Siew-Pang
SP
Chan
Department of Cardiology, The First Affiliated Hospital of Soochow University, PR China.
Xin
X
Zhao
Department of Cardiology, The First Affiliated Hospital of Soochow University, PR China. Electronic address: yang_xiangjun57@sina.com.
Xiang-Jun
XJ
Yang
D000368:Aged; D001798:Blood Proteins; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D011446:Prospective Studies; D012720:Severity of Illness Index
D001798:Blood Proteins; D008076:Cholesterol, HDL; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D003404:Creatinine
Adropin; Insulin resistance; Predictor; Stable coronary artery disease; Syntax score