[Liquid chromatography for determination of disulfiramin workplace atmosphere].
OBJECTIVE
To establish a method for determination of disulfiram in the workplace atmosphere by liquid chromatography.


METHODS
Sampling with glass fiber filter, eluting with methanol, separating with C18 column, and determination with liquid chromatography.


RESULTS
The bearing capacity of glass fiber filter exceeded 3.45 mg per piece. The elution efficiency was 97.8%∼101.0% The relative standard deviation varied from 1.09% to 1.44%. The limit of detection was 0.1 µg/ml. The minimum detectable concentration was 0.011 mg/m³ (with sampled air volume of 45 L).


CONCLUSIONS
The method has high selectivity, accuracy, and precision and strong applicability.
Hunan Prevention And Treatment Institute For Occupational Disease, Changsha 410007, China.
Sheng
S
Fu
Hunan Prevention And Treatment Institute For Occupational Disease, Changsha 410007, China.
Zhihui
Z
Han
Hunan Prevention And Treatment Institute For Occupational Disease, Changsha 410007, China.
Keping
K
Yu
Hunan Prevention And Treatment Institute For Occupational Disease, Changsha 410007, China.
Shouquan
S
Gao
D000388:Air / Q000032:analysis; D000395:Air Pollutants, Occupational / Q000032:analysis*; D002853:Chromatography, Liquid / Q000379:methods*; D004221:Disulfiram / Q000032:analysis*; D017132:Workplace
D000395:Air Pollutants, Occupational; D004221:Disulfiram