Antimicrobial susceptibility trends among Streptococcus pneumoniae over an 11-year period in an Iranian referral children Hospital.
OBJECTIVE
The appearance of antibiotic resistance in Streptococcus pneumoniae has raised a global concern over the past three decades. This study was conducted to determine the antimicrobial susceptibility of S. pneumoniae isolated from patients in Children´s Medical Center (CMC) Hospital during 2001 to 2011.


METHODS
During the 11 years period, a total of 194 S. pneumoniae isolates were collected in CMC Hospital. Antimicrobial susceptibility testing was performed by the Kirby-Bauer disk diffusion method and time-series analysis was used to evaluate the antimicrobial susceptibility changes over the time.


CONCLUSIONS
Antimicrobial susceptibility of S. pneumoniae to different antibiotics decreased from 2001 to 2011 as: penicillin from 78% to 32%, erythromycin from 75% to 35%, chloramphenicol from 94% to 55%, ampicillin from 70% to 62%, ceftriaxone from 100% to 87%, sulfametoxazole from 57% to 40%. We did not find any significant difference between the susceptibility of isolates from sterile and non-sterile sources. It would be an important key to consider antimicrobial stewardship as an essential factor to prevent the development of antimicrobial resistance.
Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Taghi
MT
Haghi Ashtiani
Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Majid
M
Sadeghian
Departement of parasitology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Bahram
B
Nikmanesh
Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Babak
B
Pourakbari
Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Shima
S
Mahmoudi
Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran ; Department of Infectious Disease, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Setareh
S
Mamishi
Iran; S. pneumonia; antibiotic resistance