Antihypertensive peptides of animal origin: A review.
Many bioactive peptides trigger certain useful antihypertensive activities in the living body system and there is a mounting worldwide interest in the therapeutic potential of these bioactive peptides for exploitation in vivo against the hypertension. Studies suggest the antihypertensive properties for many bioactive peptides of animal origin with underlying mechanisms ranging from inhibition of angiotensin-converting enzyme to additional mechanisms to lower blood pressure such as opioid-like activities and mineral-binding and antithrombotic properties. Antihypertensive peptides are the most extensively studied of all the bioactivities induced by food protein hydrolysates, highlighting their importance in human health and disease prevention and treatment. There exist enormous opportunities for the production of novel peptide-based products in biopharmaceutical manufacturing industries for the treatment, prevention, and mitigation of hypertension. Numerous products have already struck on the global market and many more are in process. This article focuses on antihypertensive peptides identified in the meat, fish, blood, milk, dairy products, and egg and their probable application as novel ingredients in the development of functional food products as dietary treatment of hypertension.
a Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu, Livestock Products Technology, F.V.Sc. & A.H. , R. S. Pura , Jammu , India.
Zuhaib Fayaz
ZF
Bhat
b SKUAST-Jammu, Livestock Products Technology, F.V.Sc. & A.H. , R. S. Pura , Jammu , India.
Sunil
S
Kumar
c University of Kashmir , Department of Biotechnology , Hazratbal, Srinagar , India.
Hina Fayaz
HF
Bhat
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004531:Eggs / Q000032:analysis; D005343:Fibrinolytic Agents / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008892:Milk / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D007703:Peptidyl-Dipeptidase A; D011492:Protein Hydrolysates / Q000737:chemistry / Q000494:pharmacology*; D016032:Randomized Controlled Trials as Topic; D000069466:Red Meat / Q000032:analysis; D017747:Seafood / Q000032:analysis
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D005343:Fibrinolytic Agents; D010455:Peptides; D011492:Protein Hydrolysates; D007703:Peptidyl-Dipeptidase A
Bioactive peptides; antihypertensive peptides; blood; dairy products; egg; fish; meat; milk