Binge eating in pre-clinical models.
Obesity is a globally widespread disease. Approximately 35% of world population has the problem of inappropriate body weight due to sedentary lifestyle, excessive food consumption and the lack of physical activity. In the course of many years, several pharmacological anti-obesity drugs have been discovered. Most of them, however, possess severe side effects. Recent findings suggest that disturbed functioning of the reward system can be involved in the development of obesity. The data coming from clinical and animal studies provide new evidence that links excessive food consumption with compulsive behavior that can lead to binge eating disease occurrence. In this review we discuss most commonly used animal models of binge eating such as restriction/refeeding, limited access and stress schedule model, and related to them neurobiological findings as well. We also present new, anti-obesity drugs, which are characterized by central mechanism of action.
Department of Toxicology, Chair of Toxicology, Faculty of Pharmacy, Medical College, Jagiellonian University, Kraków, Poland.
Bartłomiej
B
Rospond
Department of Toxicology, Chair of Toxicology, Faculty of Pharmacy, Medical College, Jagiellonian University, Kraków, Poland.
Joanna
J
Szpigiel
Laboratory of Drug Addiction Pharmacology, Institute of pharmacology, Polish Academy of Sciences, Kraków, Poland.
Anna
A
Sadakierska-Chudy
Department of Toxicology, Chair of Toxicology, Faculty of Pharmacy, Medical College, Jagiellonian University, Kraków, Poland; Laboratory of Drug Addiction Pharmacology, Institute of pharmacology, Polish Academy of Sciences, Kraków, Poland. Electronic address: malgorzata.filip@uj.edu.pl.
Małgorzata
M
Filip
D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology / Q000627:therapeutic use*; D056912:Binge-Eating Disorder / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism / Q000523:psychology
D019440:Anti-Obesity Agents
Binge eating; Obesity; Pharmacotherapy; Reward system