Sessile serrated adenomas versus conventional adenomas. Different polyps in different populations?
OBJECTIVE
The aim of this study was to determine risk factors for the development of sessile serrated adenomas (SSA/Ps) as well as to study differences between groups with SSA/Ps and conventional adenomas (tubular, tubulovillus and villus) in the general population.


METHODS
One hundred patients with normal colonoscopies, 27 patients with 53 SSA/Ps and 69 patients with 156 conventional adenomas were studied, epidemiological data were collected and calculations of body mass index and waist-to-hip ratio were performed prior to endoscopy. A univariate and a multivariate logistic regression analysis were performed using Stata 9.0.


RESULTS
SSA/Ps had a positive association with increasing age (p = 0.01), heavy smoking (≥20 packet years) (p = 0.001) and past history of polyps (p = 0.004) in comparison to normal population. SSA/Ps showed an inverse association with conventional adenomas for diabetes mellitus (p < 0.001) and arterial hypertension (p = 0.001). Meanwhile, female sex was positively associated with SSA/P development in comparison to conventional adenomas (p = 0.031).


CONCLUSIONS
Heavy smoking as a significant risk factor for developing SSA/Ps was confirmed from this study. It also seemed that patients with diabetes mellitus and/or hypertension developed conventional adenomas more frequently than SSA/Ps; on the contrary, females were at higher risk of developing SSA/Ps than conventional adenomas.
Gastroenterology Department, Tzaneion General Hospital of Piraeus, Zani and Afenbtouli, 1, Piraeus, 18536, Greece, gmicha78@hotmail.com.
Georgios
G
Michalopoulos
Spyridon
S
Vrakas
Vassiliki
V
Ntouli
Stelios
S
Lamprinakos
Konstantinos
K
Makris
Charalampos
C
Tzathas
D000236:Adenoma / Q000145:classification / Q000453:epidemiology* / Q000209:etiology*; D000328:Adult; D000368:Aged; D000375:Aging; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D006973:Hypertension; D007417:Intestinal Polyps; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D049629:Waist-Hip Ratio