Total synthesis and structural revision of (+)-muironolide a.
Muironolide A is a fascinating tetrachlorinated marine polyketide isolated from the sponge of Phorbas sp. Only 90 μg had been isolated, and the structure was established by nanoscale NMR techniques. Herein we report the total synthesis of the substance with the assigned structure of muironolide A, propose a revised structure based on NMR data, and complete the enantioselective total synthesis of muironolide A.
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.
Qing
Q
Xiao
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.
Kyle
K
Young
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.
Armen
A
Zakarian
D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D054833:Isoindoles; C568569:muironolide A