Evidence-based early interventions for individuals at clinical high risk for psychosis: a review of treatment components.
Youth and young adults at clinical high risk (CHR) for psychosis experience a broad range of difficulties, including attenuated psychotic symptoms, comorbid concerns, functional impairments, and family and interpersonal stress. Given emerging evidence that early interventions may improve functioning and reduce symptomatology while also lowering risk of transition to full-threshold psychosis, several randomized controlled trials have systematically evaluated the efficacy of CHR treatment approaches. This article describes and summarizes psychosocial intervention approaches that have demonstrated efficacy in treating people at CHR, with a focus on distilling individual components of these treatments. On the basis of the existing literature, we propose an empirically based, flexible, and comprehensive modularized approach to early intervention that meets the varying needs of individuals experiencing CHR-related distress and dysfunction, many of whom may be on a trajectory toward psychosis.
*Department of Psychology, University of Maryland, Baltimore County; †Division of Child and Adolescent Psychiatry, University of Maryland, Baltimore; ‡Department of Psychology and Neuroscience, University of Colorado at Boulder; and §School of Social Work and ∥Maryland Psychiatric Research Center, School of Medicine, University of Maryland, Baltimore.
Elizabeth
E
Thompson
Zachary B
ZB
Millman
Nana
N
Okuzawa
Vijay
V
Mittal
Jordan
J
DeVylder
Travis
T
Skadberg
Robert W
RW
Buchanan
Gloria M
GM
Reeves
Jason
J
Schiffman
D000293:Adolescent; D017028:Caregivers / Q000193:education; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D018450:Disease Progression; D061345:Early Medical Intervention; D019317:Evidence-Based Medicine; D005196:Family Therapy; D020022:Genetic Predisposition to Disease; D006801:Humans; D010347:Patient Care Planning; D062706:Prodromal Symptoms; D011615:Psychotherapy, Group; D011618:Psychotic Disorders / Q000235:genetics / Q000523:psychology / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D012917:Social Adjustment; D055815:Young Adult