Effect of urethral infusion of atracurium besylate on manual bladder expression in dogs and cats with spinal cord injuries: a randomised trial.
The aim of this randomised trial was to assess the effect of urethral infusion of atracurium besylate in dogs and cats with signs of urinary retention secondary to lesions affecting spinal cord segments T3-L3. Eighteen dogs and six cats with urinary retention were examined and scored before treatment on the degree of difficulty of inducing bladder emptying by manual bladder compression. Animals were subsequently treated in a blinded fashion by the same operator with urethral infusion of 2-4 ml of either a solution of 0.5 mg/ml of atracurium (treatment group) or placebo (control group) and, after five minutes, a second attempt was made to induce bladder emptying by manual compression and a post-treatment score assigned. Pretreatment scores did not differ between the treatment and control groups (5.6±0.8 v 6.2±0.7, respectively; P=0.22); however, post-treatment scores were significantly lower in the treatment group compared with the control group (2.9±0.4 v 5.9±0.3; P<0.05). Urethral infusion of atracurium facilitates manual bladder expression in dogs and cats with urinary retention secondary to spinal cord injuries. No side effects were recognised.
Veterinary Clinic Castellarano, Castellarano (RE), Italy.
F
F
Galluzzi
Department of Veterinary Medicine, University of Parma, Parma, Italy.
F
F
De Rensis
Department of Veterinary Medicine, University of Parma, Parma, Italy.
R
R
Saleri
Veterinary Clinic Castellarano, Castellarano (RE), Italy.
G
G
Spattini
D000818:Animals; D001279:Atracurium / Q000008:administration & dosage / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome; D014521:Urethra; D014554:Urination
D003473:Neuromuscular Nondepolarizing Agents; D001279:Atracurium
Cats; Dogs; Trauma; Treatment; Urinary tract