Modulation of NF-κB in rescued irradiated cells.
Studies by different groups on the rescue effect, where unirradiated bystander cells mitigated the damages in the irradiated cells, since its discovery by the authors' group in 2011 were first reviewed. The properties of the rescue effect were then examined using a novel experimental set-up to physically separate the rescue signals from the bystander signals. The authors' results showed that the rescue effect was mediated through activation of the nuclear factor-κB (NF-κB) response pathway in the irradiated cells, and that the NF-κB activation inhibitor BAY-11-7082 did not affect the activation of this response pathway in the irradiated cells induced by direct irradiation.
Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Hong Kong.
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Lam
Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Hong Kong.
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Fung
Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.
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Han
Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Hong Kong.
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Li
Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Hong Kong.
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Chiu
Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Hong Kong State Key Laboratory in Marine Pollution, City University of Hong Kong, Tat Chee Avenue, Hong Kong.
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Cheng
Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Hong Kong Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China State Key Laboratory in Marine Pollution, City University of Hong Kong, Tat Chee Avenue, Hong Kong peter.yu@cityu.edu.hk.
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D000222:Adaptation, Physiological / Q000502:physiology* / Q000528:radiation effects; D000512:Alpha Particles; D024201:Bystander Effect / Q000502:physiology* / Q000528:radiation effects; D002470:Cell Survival / Q000502:physiology* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005786:Gene Expression Regulation / Q000502:physiology* / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D011829:Radiation Dosage; D015398:Signal Transduction / Q000502:physiology* / Q000528:radiation effects
D016328:NF-kappa B