The expression of astrocyte elevated gene-1 in human non-small-cell lung cancer and its relationship with postoperative chemotherapy and radiotherapy.
OBJECTIVE
To examine the expression of astrocyte elevated gene-1 (AEG-1) in non-small-cell lung cancer (NSCLC) and analyse the correlation between AEG-1 expression and the prognosis of the patients, particularly the relationship between AEG-1 expression and postoperative chemotherapy and radiotherapy.


METHODS
The expression of AEG-1 was analysed by immunohistochemistry in 225 primary NSCLC specimens and 42 adjacent normal lung tissue specimens. Statistical analyses were performed to evaluate the correlation between AEG-1 expression and the clinicopathological characteristics of the patients as well as the predictive value of AEG-1.


RESULTS
The expression of AEG-1 was associated with the pathological stage (P < 0.001) and lymph node status (P = 0.028). A multivariate analysis indicated that AEG-1 expression was an independent prognostic factor for both overall survival (OS) and disease-free survival (DFS). In the postoperative chemotherapy group, the OS (P = 0.014) and DFS (P = 0.009) in the low AEG-1 expression group were longer than the survival times in the high AEG-1 expression group. In the postoperative radiotherapy group, the local recurrence-free survival was significantly shorter in patients whose tumours showed high AEG-1 expression (P = 0.016).


CONCLUSIONS
AEG-1 expression could be a predictor for OS and DFS in NSCLC patients. Patients with low AEG-1 expression received the greatest benefit from both postoperative chemotherapy and radiotherapy.
Department of Radiation Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Shan
S
Lu
Department of Radiation Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Jianyu
J
Xu
Department of Radiation Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.|Institute of Cancer Prevention and Treatment of Heilongjiang Province, Harbin, China.
Xiangying
X
Xu
Department of Radiation Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Songliu
S
Hu
Department of Plastic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Bin
B
Li
Department of Radiation Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Wenxin
W
Li
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy / Q000601:surgery; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D011379:Prognosis; D016601:RNA-Binding Proteins; D016896:Treatment Outcome
D015815:Cell Adhesion Molecules; C483039:MTDH protein, human; D008565:Membrane Proteins; D016601:RNA-Binding Proteins
astrocyte elevated gene-1; chemotherapy; immunohistochemistry; non-small-cell lung carcinoma; radiotherapy