[Vascular Calcification - Pathological Mechanism and Clinical Application - . Mechanisms of vascular calcification].
Vascular calcification is an independent risk factor for the development of cardiovascular disease and is classified into two types based on the site of calcification : intimal atherosclerotic calcification and Mönckeberg's medial calcification. Matrix vesicles released from macrophages and vascular smooth muscle cells (VSMC) during apoptosis play a pivotal role in formation of fine granular calcification, while osteogenic differentiation of VSMC contributes to progression of advanced calcification. Recent noninvasive imaging studies of atherosclerotic calcification provide robust evidence that inflammation precedes active calcification, leading to establish the inflammation-dependent calcification paradigm. On the other hand, elastin degradation by increased elastolytic activities and disturbance of regulatory systems of extracellular pyrophosphate metabolism play an important role in development of Mönckeberg's medial calcification.
Department of Geriatrics and Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Japan.
Atsushi
A
Shioi
D000818:Animals; D017209:Apoptosis; D002114:Calcinosis; D002318:Cardiovascular Diseases / Q000209:etiology; D016922:Cellular Senescence; D011756:Diphosphates / Q000378:metabolism; D004549:Elastin / Q000378:metabolism; D005109:Extracellular Matrix; D006801:Humans; D008264:Macrophages; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000166:cytology* / Q000378:metabolism / Q000473:pathology*; D010012:Osteogenesis; D012307:Risk Factors; D061205:Vascular Calcification / Q000145:classification / Q000209:etiology*
D011756:Diphosphates; D004549:Elastin