Protective effect of compression socks in a marathon runner with a genetic predisposition to thrombophilia due to Factor V Leiden.
BACKGROUND
The present case study is an analysis of the effect of compression socks on hemostatic activation following a marathon in a female endurance athlete found to be heterozygous for the coagulation factor V (F5 1691 G>A [Arg>Gln rs6025/560]) risk allele that predisposes one to a genetically inherited disorder of blood clotting, Factor V Leiden.


METHODS
Markers for coagulation and fibrinolysis were obtained 24 h prior to (PRE), immediately after (FINISH) and 24 h after (POST) completion of two marathons: the first in which the runner was not wearing compression socks, and the second in which the runner wore compression socks throughout the race.


RESULTS
Compression socks worn during a marathon appeared to lower the overall impact on hemostasis as well as clot formation in this particular athlete as evidenced by lower t-PA (-56%), TAT (-63%) and D-dimer (-30%).


CONCLUSIONS
Hemostatic activation may be lower with the use of compression socks, and thus may be effective for preserving hemostasis in endurance athletes at risk.
a 1 Department of Cardiology, Henry Low Heart Center, Hartford Hospital , Hartford, CT, USA.
Amanda L
AL
Zaleski
Linda S
LS
Pescatello
Paul D
PD
Thompson
Beth A
BA
Taylor
D000328:Adult; D000990:Antithrombin III; D015415:Biomarkers / Q000097:blood; D005165:Factor V / Q000235:genetics*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D020022:Genetic Predisposition to Disease; D006487:Hemostasis; D006579:Heterozygote; D006801:Humans; D010447:Peptide Hydrolases / Q000097:blood; D010807:Physical Endurance / Q000502:physiology*; D012420:Running / Q000502:physiology*; D053828:Stockings, Compression; D019851:Thrombophilia / Q000235:genetics / Q000503:physiopathology*; D010959:Tissue Plasminogen Activator / Q000097:blood
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C046193:antithrombin III-protease complex; C095381:factor V Leiden; C036309:fibrin fragment D; D000990:Antithrombin III; D005165:Factor V; D010447:Peptide Hydrolases; D010959:Tissue Plasminogen Activator
Factor V Leiden; Marathon; compression socks; hemostasis