New insights into the role of ID proteins in breast cancer metastasis: a MET affair.
The establishment of lethal metastases depends on the capacity of a small number of cancer cells to regenerate a tumor after entering a target organ. Stankic and colleagues have identified a role for the inhibitor of differentiation protein, ID1, as a critical regulator of breast cancer stem-like properties and metastatic colonization. Under the control of tumor growth factor-beta signaling, ID1 induces mesenchymal-epithelial transition at the metastatic site by antagonizing the activity of the basic helix-loop-helix transcription factor Twist1. This study sheds light on mechanisms that initiate metastatic outgrowth, and strengthens the concept that epithelial-mesenchymal plasticity is crucial at different stages of metastasis.
Cancer Research Division, The Kinghorn Cancer Centre and Cancer Research Program Garvan Institute of Medical Research, 370 Victoria St, Darlinghurst, NSW, 2010, Australia . w.tea@garvan.org.au.|St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia . w.tea@garvan.org.au.
Wee Siang
WS
Teo
Cancer Research Division, The Kinghorn Cancer Centre and Cancer Research Program Garvan Institute of Medical Research, 370 Victoria St, Darlinghurst, NSW, 2010, Australia . r.nair@garvan.org.au.|St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia . r.nair@garvan.org.au.
Radhika
R
Nair
Cancer Research Division, The Kinghorn Cancer Centre and Cancer Research Program Garvan Institute of Medical Research, 370 Victoria St, Darlinghurst, NSW, 2010, Australia . a.swarbrick@garvan.org.au.|St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia . a.swarbrick@garvan.org.au.
Alexander
A
Swarbrick
D001943:Breast Neoplasms / Q000378:metabolism*; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D006801:Humans; D051798:Inhibitor of Differentiation Protein 1 / Q000378:metabolism*; D008175:Lung Neoplasms / Q000556:secondary*; D009687:Nuclear Proteins / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D051879:Twist-Related Protein 1 / Q000378:metabolism*
D051798:Inhibitor of Differentiation Protein 1; D009687:Nuclear Proteins; D016212:Transforming Growth Factor beta; D051879:Twist-Related Protein 1