Two Rapidly Growing Mycobacterial Species Isolated from a Brain Abscess: First Whole-Genome Sequences of Mycobacterium immunogenum and Mycobacterium llatzerense.
Rapidly growing mycobacteria are rarely found in central nervous system infections. We describe a case of polymicrobial infection in a brain abscess including two rapidly growing Mycobacterium species, M. immunogenum and M. llatzerense. The Mycobacterium isolates were distinguishable by molecular methods, and whole-genome sequencing showed <60% pairwise nucleotide identity.
Department of Laboratory Medicine, University of California, San Francisco, California, USA UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, USA.
Alexander L
AL
Greninger
Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, California, USA.
Charles
C
Langelier
Department of Laboratory Medicine, University of California, San Francisco, California, USA.
Gail
G
Cunningham
Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, California, USA.
Chris
C
Keh
Department of Internal Medicine, University of California San Francisco, San Francisco, California, USA.
Michael
M
Melgar
Department of Laboratory Medicine, University of California, San Francisco, California, USA UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, USA Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, California, USA.
Charles Y
CY
Chiu
Department of Laboratory Medicine, University of California, San Francisco, California, USA UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, California, USA Steve.Miller@ucsfmedctr.org.
Steve
S
Miller
D000328:Adult; D001922:Brain Abscess / Q000175:diagnosis* / Q000382:microbiology; D060085:Coinfection / Q000175:diagnosis / Q000382:microbiology; D005260:Female; D016680:Genome, Bacterial; D006257:Head / Q000000981:diagnostic imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008969:Molecular Sequence Data; D009165:Mycobacterium Infections, Nontuberculous / Q000175:diagnosis* / Q000382:microbiology; D009170:Nontuberculous Mycobacteria / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D011859:Radiography; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid