RAI2: Linking Retinoic Acid Signaling with Metastasis Suppression.
Considerable evidence points to the importance of disseminated tumor cells, which are commonly detected in the bone marrow and display features of cellular plasticity, in predicting the clinical outcome of breast cancer. In this issue of Cancer Discovery, Werner and colleagues report on the discovery of retinoic acid-induced 2 (RAI2) as a differentiation factor that suppresses early metastatic spread of estrogen receptor-positive breast cancer.
Department of Molecular Biology, Princeton University, Princeton, New Jersey.
Mark
M
Esposito
Department of Molecular Biology, Princeton University, Princeton, New Jersey. ykang@princeton.edu.
Yibin
Y
Kang
D001853:Bone Marrow / Q000473:pathology*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D011506:Proteins / Q000235:genetics*
D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; C118924:RAI2 protein, human