Helicobacter pylori infection and inflammatory bowel disease in Asians: a meta-analysis.
OBJECTIVE
To investigate the relationship between Helicobacter pylori infection and inflammatory bowel disease (IBD) in an Asian population.


METHODS
The PubMed, EMBASE, and Cochrane Library databases were searched for observational studies published up until June 2014, without language restrictions. Additional references were obtained from reviewed articles.


RESULTS
Ten studies involving 1299 IBD patients and 1817 controls were included in the meta-analysis (24.9% of IBD patients had H. pylori infection vs 48.3% of the controls). The pooled risk ratio for H. pylori infection in IBD patients compared with controls was 0.48 (95%CI: 0.43-0.54; P < 0.001). There was no significant heterogeneity in the included studies (I (2) = 21%). Egger's linear regression indicated that there was no significant publication bias (P = 0.203).


CONCLUSIONS
The H. pylori infection rate in Asian IBD patients is significantly lower than in non-IBD patients, indicating that infection protects against the development of IBD.
Xiao-Wei Wu, Hong-Zan Ji, Miao-Fang Yang, Lin Wu, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
Xiao-Wei
XW
Wu
Xiao-Wei Wu, Hong-Zan Ji, Miao-Fang Yang, Lin Wu, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
Hong-Zan
HZ
Ji
Xiao-Wei Wu, Hong-Zan Ji, Miao-Fang Yang, Lin Wu, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
Miao-Fang
MF
Yang
Xiao-Wei Wu, Hong-Zan Ji, Miao-Fang Yang, Lin Wu, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
Lin
L
Wu
Xiao-Wei Wu, Hong-Zan Ji, Miao-Fang Yang, Lin Wu, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
Fang-Yu
FY
Wang
D001208:Asia / Q000453:epidemiology; D044466:Asian People; D016481:Helicobacter Infections / Q000175:diagnosis / Q000208:ethnology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000208:ethnology* / Q000382:microbiology / Q000517:prevention & control; D065840:Protective Factors; D012307:Risk Factors
Asian population; Crohn’s disease; Helicobacter pylori; Inflammatory bowel disease; Meta-analysis; Ulcerative colitis