Association of mitochondrial DNA haplogroups and vascular complications of diabetes mellitus: A population-based study.
We investigated whether mitochondrial (mtDNA) haplogroups and maternal family history of diabetes mellitus were associated with vascular diabetes mellitus complications in a population-based cohort of 299 Finnish diabetes mellitus patients with disease onset in young adult age. We found that haplogroup U was more prevalent among patients with no vascular diabetes mellitus complications than among those with at least one complication (p = 0.038). Haplogroup U was also more prevalent among the patients who reported maternal family history of diabetes mellitus than among those who did not (p = 0.0013). Furthermore, haplogroup U was more prevalent among patients with maternal family history of diabetes mellitus but no vascular diabetes mellitus complications than among those with at least one vascular diabetes mellitus complication but no maternal family history of diabetes mellitus (p = 0.0003 for difference). These findings suggest that different mtDNA-related factors may influence the risk of diabetes mellitus per se and the risk of vascular diabetes mellitus complications. Further studies are, however, warranted to replicate and elaborate on these results.
Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland mikmar@utu.fi.
Mika H
MH
Martikainen
Division of Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Tapani
T
Rönnemaa
Department of Clinical Medicine, Neurology, University of Oulu and Oulu University Hospital, Oulu, Finland Medical Research Center Oulu, Oulu, Finland.
Kari
K
Majamaa
D002545:Brain Ischemia / Q000235:genetics; D015331:Cohort Studies; D004272:DNA, Mitochondrial / Q000235:genetics*; D003920:Diabetes Mellitus / Q000235:genetics*; D003925:Diabetic Angiopathies / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics; D003930:Diabetic Retinopathy / Q000235:genetics; D005260:Female; D005387:Finland; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D002546:Ischemic Attack, Transient / Q000235:genetics; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000235:genetics; D017202:Myocardial Ischemia / Q000235:genetics; D058729:Peripheral Arterial Disease / Q000235:genetics; D012189:Retrospective Studies; D020521:Stroke / Q000235:genetics
D004272:DNA, Mitochondrial
Diabetes mellitus; mitochondrial DNA; mitochondrial disease; mitochondrial haplogroups; vascular complications