Characterization of the toughness and elastic properties of fresh and cryopreserved arteries.
Surgical interventions are used to manage severe complications of heart valve diseases and to prevent the eventual rupture of an aortic aneurysm. Soft-tissue allografts, xenografts, and prosthetic grafts are used in these interventions; however, there are pre-surgical difficulties and post-surgical complications in using these grafts. One of these is the rupture potential of cryopreserved allografts at the time of transplantation and/or after the thawing process for the cryopreserved tissue. Moreover, a number of clinical observations report the patency of prosthetic grafts and aneurysm of cryopreserved allografts after the transplantation. This work aims to study the effect of cryopreservation on the resistance of arterial tissue to crack growth and propagation; we examined the biomechanical parameters which could be used in designing more efficient prosthetic grafts. Investigation of the toughness properties can also be helpful to understand the failure mechanisms of pathological arterial tissues. The toughness and biaxial tensile properties of the post-cryopreserved and fresh arteries have been examined.
Department of Mechanical Engineering, McGill University, Montréal, Québec, Canada H3A 0C3; Montreal Heart Institute, Montréal, Québec, Canada H1T 1C.
Nastaran
N
Shahmansouri
Montreal Heart Institute, Montréal, Québec, Canada H1T 1C.
Raymond
R
Cartier
Department of Mechanical Engineering, McGill University, Montréal, Québec, Canada H3A 0C3; Montreal Heart Institute, Montréal, Québec, Canada H1T 1C. Electronic address: rosaire.mongrain@mcgill.ca.
Rosaire
R
Mongrain
D000818:Animals; D001011:Aorta; D001696:Biomechanical Phenomena; D015925:Cryopreservation; D004548:Elasticity; D006801:Humans; D034421:Sus scrofa
Arteries; Biaxial tensile testing; Cryopreservation; Loss factor; Toughness