Testosterone regulates cardiac calcium homeostasis with enhanced ryanodine receptor 2 expression through activation of TGF-β.
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Jung-Chieh
JC
Hsu
Division of Cardiology, Chi-Mei Medical Center, Tainan, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Chen-Chuan
CC
Cheng
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Medical Education and Research, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Yu-Hsun
YH
Kao
Department of Biomedical Engineering, National Defense Medical Center, Taipei, Taiwan.
Yao-Chang
YC
Chen
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Cheng-Chih
CC
Chung
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: yjchen@tmu.edu.tw.
Yi-Jen
YJ
Chen
D000818:Animals; D002118:Calcium / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D007424:Intracellular Fluid / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000502:physiology*; D019837:Ryanodine Receptor Calcium Release Channel / Q000096:biosynthesis*; D013739:Testosterone / Q000494:pharmacology* / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D019837:Ryanodine Receptor Calcium Release Channel; D016212:Transforming Growth Factor beta; D013739:Testosterone; D002118:Calcium
Androgen; Calcium transients; Ryanodine receptor 2; Transforming growth factor β