Combined T2w volumetry, DW-MRI and DCE-MRI for response assessment after neo-adjuvant chemoradiation in locally advanced rectal cancer.
BACKGROUND
To assess the value of combined T2-weighted magnetic resonance imaging (MRI) (T2w) volumetry, diffusion-weighted (DW)-MRI and dynamic contrast enhanced (DCE)-MRI for pathological response prediction after neo-adjuvant chemoradiation (CRT) in locally advanced rectal cancer (LARC).


METHODS
MRI with DW-MRI and DCE-MRI sequences was performed before start of CRT and before surgery. After surgery, the tumor regression grade (TRG) was obtained based on the score by Mandard et al. Pathological complete responders (pCR, TRG 1), and pathological good responders (GR, TRG 1 + 2) were compared to non-pCR and non-GR patients, respectively.


RESULTS
In total 55 patients were analyzed, six had a pCR (10.9%) and 10 a GR (18.2%). Favorable responders had a larger decrease in tumor volume and Ktrans and a larger increase in apparent diffusion coefficient (ADC) values compared to non-responders. ADC change showed the best diagnostic accuracy for pCR. For GR, the model including ADC change and volume change showed the best diagnostic performance. However, this performance was not statistically better compared to the model with ADC change alone. Inclusion of Ktrans change did not increase the diagnostic accuracy for pathological favorable response.


CONCLUSIONS
This explorative study showed that ADC change is a promising diagnostic tool for pCR and GR. Volume decrease showed potential limited additional diagnostic value for GR while Ktrans change showed no additional diagnostic value for pCR and GR.
a Department of Radiotherapy , University Medical Center Utrecht , Utrecht , The Netherlands.
Martijn
M
Intven
b Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht , Utrecht , The Netherlands.
Evelyn M
EM
Monninkhof
a Department of Radiotherapy , University Medical Center Utrecht , Utrecht , The Netherlands.
Onne
O
Reerink
a Department of Radiotherapy , University Medical Center Utrecht , Utrecht , The Netherlands.
Marielle E P
ME
Philippens
D000230:Adenocarcinoma / Q000556:secondary* / Q000628:therapy*; D019540:Area Under Curve; D059248:Chemoradiotherapy; D003287:Contrast Media; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012004:Rectal Neoplasms / Q000473:pathology* / Q000628:therapy*; D047368:Tumor Burden
D003287:Contrast Media