Association Between PARP1 Single Nucleotide Polymorphism and Brain Tumors.
To systematically evaluate the association between poly(ADP-ribose) polymerase 1 (PARP1) rs1136410 T>C and brain tumor risk, a meta-analysis has been carried out. We performed a meta-analysis of 2004 brain tumor patients and 2944 controls by use of STATA version 12.0 to determine whether the risk of brain tumors was associated with the genotypes or alleles of rs1136410 T>C. We found a significantly decreased risk (ranging from 0.18- to 0.16-fold) in the dominant model (OR = 0.84, 95% CI = 0.75-0.95), the C vs. T model (OR = 0.82, 95% CI = 0.74-0.91), and the CT vs. TT model (OR = 0.86, 95% CI = 0.76-0.98). The same genetic models demonstrated noteworthy associations when analysis was restrained to glioma (OR = 0.85, 95% CI = 0.75-0.96; OR = 0.83, 95% CI = 0.74-0.92; OR = 0.87, 95% CI = 0.76-0.99, respectively). This meta-analysis suggests that PARP1 rs1136410 T>C may play a significant role in the protection against the development of brain tumors and glioma.
Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Fengtai Area, Beijing, China. wanghong56@hotmail.com.
Hong
H
Wang
Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Fengtai Area, Beijing, China.
Kun
K
Zhang
Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Fengtai Area, Beijing, China.
Haifeng
H
Qin
Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Fengtai Area, Beijing, China.
Lin
L
Yang
Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Fengtai Area, Beijing, China.
Liyu
L
Zhang
Department of Lung Cancer, 307 Hospital of PLA, Affiliated Hospital of Academy of Military Medical Sciences, Fengtai Area, Beijing, China.
Yanyan
Y
Cao
D001932:Brain Neoplasms / Q000201:enzymology* / Q000235:genetics*; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D000071137:Poly (ADP-Ribose) Polymerase-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
C499320:PARP1 protein, human; D000071137:Poly (ADP-Ribose) Polymerase-1
Brain tumor; PARP1; Polymorphism