A comparison study of immune-inflammatory response in electroacupuncture and transcutaneous electrical nerve stimulation for patients undergoing supratentorial craniotomy.
OBJECTIVE
The effect of transcutaneous electrical nerve stimulation (TENS) on immuno-inflammatory response was tested and the differences between electroacupuncture (EA) and TENS in immuno-inflammatory response in patients undergoing supratentorial craniotomy were explored.


METHODS
51 patients received craniotomy were divided randomly into 3 groups: control (group C, n=18), EA (group A, n=19) and TENS (group T, n=14) groups. Blood samples were collected before anesthesia (T0) and 30 min (T1), 2 h (T2) and 4 h (T3) after induction of anesthesia to measure the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-8, IL-10, IgM, IgA and IgG..


RESULTS
No significant difference existed between groups A and group T during craniotomy. IgM and IgA decreased significantly in group C compared with groups A and T at T2 and T3 time points. Compared with group C, there were significant difference in TNF-α, IgM and IgA level at T0 in groups A and T; no significant difference was found in the levels of IgG, IL-10 and IL-8.


CONCLUSIONS
EA and TENS could reduce immunosuppression in patients undergoing supratentorial craniotomy and it has significance in choice of treatment in immunosuppressive therapy.
Department of Anesthesiology, North China Grid Company Limited Beijing Electric Power Hospital Beijing, China.
Guoyan
G
Li
Department of Anesthesiology, Beijing Tiantan Hospital Beijing, China.
Shuqin
S
Li
Department of Anesthesiology, North China Grid Company Limited Beijing Electric Power Hospital Beijing, China.
Lizhi
L
Sun
Department of General Surgery, North China Grid Company Limited Beijing Electric Power Hospital Beijing, China.
Fangcai
F
Lin
Department of Anesthesiology and Pain Management, Beijing Sanbo Brain Hospital Beijing, China.
Baoguo
B
Wang
Transcutaneous electrical nerve stimulation (TENS); electroacupuncture (EA); immuno-inflammatory; supratentorial craniotomy