Histone methylations in heart development, congenital and adult heart diseases.
Heart development comprises myocyte specification, differentiation and cardiac morphogenesis. These processes are regulated by a group of core cardiac transcription factors in a coordinated temporal and spatial manner. Histone methylation is an emerging epigenetic mechanism for regulating gene transcription. Interplay among cardiac transcription factors and histone lysine modifiers plays important role in heart development. Aberrant expression and mutation of the histone lysine modifiers during development and in adult life can cause either embryonic lethality or congenital heart diseases, and influences the response of adult hearts to pathological stresses. In this review, we describe current body of literature on the role of several common histone methylations and their modifying enzymes in heart development, congenital and adult heart diseases.
Department of Internal Medicine-Cardiology Division & Molecular Biology, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX, 75350, USA.
Qing-Jun
QJ
Zhang
Zhi-Ping
ZP
Liu
D000818:Animals; D006332:Cardiomegaly / Q000235:genetics* / Q000378:metabolism*; D006321:Heart / Q000196:embryology*; D006330:Heart Defects, Congenital / Q000235:genetics* / Q000378:metabolism*; D006331:Heart Diseases / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D051379:Mice; D009206:Myocardium / Q000378:metabolism
D006657:Histones
cardiac hypertrophy; congenital heart disease; demethylase; epigenetics; heart development; histone; methyltransferase