Pharmacokinetics and Pharmacodynamics of the SGLT2 Inhibitor Remogliflozin Etabonate in Subjects with Mild and Moderate Renal Impairment.
Remogliflozin etabonate (RE), the prodrug of remogliflozin, is an inhibitor of the sodium glucose-dependent renal transporter 2 (SGLT2), enabling urinary glucose excretion to reduce hyperglycemia for the treatment of type 2 diabetes. Renal function declines more rapidly in patients with type 2 diabetes, making it difficult or unsafe to continue on some antidiabetic therapeutics. In an initial effort to understand the potential utility of RE in patients with renal impairment, the pharmacodynamics and pharmacokinetics of RE were evaluated in a single oral dose (250 mg) in patients with renal impairment as compared with control subjects. As shown by pharmacodynamic measurements of urinary glucose excretion, there was no clinically significant reduction in the ability of remogliflozin to inhibit SGLT2. In addition, there were no significant changes in area under the curve (from 0 to infinity) or half-life of remogliflozin, suggesting renal impairment does not alter the pharmacokinetics of remogliflozin. In contrast to other SGLT2 inhibitors which accumulate in patients with renal impairment, adjustment of the dosage of RE in subjects with mild or moderate renal impairment is not indicated based on the observations in this study.
GlaxoSmithKline, Research Triangle Park, North Carolina (R.O.-S., A.K., E.K.H., J.Y., L.W.-S., W.T., R.L.D.); and BHV Pharma, Raleigh, North Carolina (S.W., B.C., W.O.W.).
Robin
R
O'Connor-Semmes
GlaxoSmithKline, Research Triangle Park, North Carolina (R.O.-S., A.K., E.K.H., J.Y., L.W.-S., W.T., R.L.D.); and BHV Pharma, Raleigh, North Carolina (S.W., B.C., W.O.W.).
Susan
S
Walker
GlaxoSmithKline, Research Triangle Park, North Carolina (R.O.-S., A.K., E.K.H., J.Y., L.W.-S., W.T., R.L.D.); and BHV Pharma, Raleigh, North Carolina (S.W., B.C., W.O.W.).
Anita
A
Kapur
GlaxoSmithKline, Research Triangle Park, North Carolina (R.O.-S., A.K., E.K.H., J.Y., L.W.-S., W.T., R.L.D.); and BHV Pharma, Raleigh, North Carolina (S.W., B.C., W.O.W.).
Elizabeth K
EK
Hussey
GlaxoSmithKline, Research Triangle Park, North Carolina (R.O.-S., A.K., E.K.H., J.Y., L.W.-S., W.T., R.L.D.); and BHV Pharma, Raleigh, North Carolina (S.W., B.C., W.O.W.).
June
J
Ye
GlaxoSmithKline, Research Triangle Park, North Carolina (R.O.-S., A.K., E.K.H., J.Y., L.W.-S., W.T., R.L.D.); and BHV Pharma, Raleigh, North Carolina (S.W., B.C., W.O.W.).
Laurene
L
Wang-Smith
GlaxoSmithKline, Research Triangle Park, North Carolina (R.O.-S., A.K., E.K.H., J.Y., L.W.-S., W.T., R.L.D.); and BHV Pharma, Raleigh, North Carolina (S.W., B.C., W.O.W.).
Wenli
W
Tao
GlaxoSmithKline, Research Triangle Park, North Carolina (R.O.-S., A.K., E.K.H., J.Y., L.W.-S., W.T., R.L.D.); and BHV Pharma, Raleigh, North Carolina (S.W., B.C., W.O.W.).
Robert L
RL
Dobbins
GlaxoSmithKline, Research Triangle Park, North Carolina (R.O.-S., A.K., E.K.H., J.Y., L.W.-S., W.T., R.L.D.); and BHV Pharma, Raleigh, North Carolina (S.W., B.C., W.O.W.).
Bentley
B
Cheatham
GlaxoSmithKline, Research Triangle Park, North Carolina (R.O.-S., A.K., E.K.H., J.Y., L.W.-S., W.T., R.L.D.); and BHV Pharma, Raleigh, North Carolina (S.W., B.C., W.O.W.) bill@bhvpharma.com.
William O
WO
Wilkison
D000328:Adult; D000368:Aged; D019540:Area Under Curve; D005260:Female; D005960:Glucosides / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000494:pharmacology*; D006029:Glycosuria / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000494:pharmacology*; D007674:Kidney Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000494:pharmacology*; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors
D005960:Glucosides; D007004:Hypoglycemic Agents; D011720:Pyrazoles; C089180:SLC5A2 protein, human; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; C532127:remogliflozin etabonate