Tandem Z-Selective Cross-Metathesis/Dihydroxylation: Synthesis of anti-1,2-Diols.
A stereoselective synthesis of anti-1,2-diols has been developed using a multitasking Ru catalyst in an assisted tandem catalysis protocol. A cyclometalated Ru complex catalyzes first a Z-selective cross-metathesis of two terminal olefins, followed by a stereospecific dihydroxylation. Both steps are catalyzed by Ru, as the Ru complex is converted to a dihydroxylation catalyst upon addition of NaIO4. A variety of olefins were transformed into valuable, highly functionalized, and stereodefined molecules. Mechanistic experiments were performed to probe the nature of the oxidation step and catalyst inhibition pathways. These experiments point the way to more broadly applicable tandem catalytic transformations.
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA).
Peter K
PK
Dornan
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA).
Zachary K
ZK
Wickens
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (USA). rhg@caltech.edu.
Robert H
RH
Grubbs
D000438:Alcohols / Q000138:chemical synthesis / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D018360:Crystallography, X-Ray; D006900:Hydroxylation; D008968:Molecular Conformation; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
D000438:Alcohols; D000475:Alkenes; D056831:Coordination Complexes; D012428:Ruthenium
Z-selectivity; anti-diols; dihydroxylation; metathesis; tandem reactions