New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression.
Two novel meroterpenoids, yaminterritrems A (1) and B (2), were isolated from Aspergillus terreus collected from hot spring zones in Yang-Ming Mountain, Taiwan, and cultured at 40 °C. The structures of 1 and 2 were elucidated by NMR, MS spectral and X-ray crystallographic analyses. The biosynthetic route for 1 and 2 involving the conversion of the sesquiterpene with phenyl-α-pyrone is proposed. Besides, 2 exhibited a dose-dependent inhibitory effect on COX-2 expression in LPS-stimulated RAW264.7 macrophages.
†Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.|‡Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.|§Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chih-Chuang
CC
Liaw
†Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.|∥Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan.|§Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
Yu-Liang
YL
Yang
†Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Chun-Kuang
CK
Lin
§Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.|▽Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jin-Ching
JC
Lee
ΔGenomics Research Center, Academia Sinica, Taipei 115, Taiwan.
Wen-Ying
WY
Liao
ΔGenomics Research Center, Academia Sinica, Taipei 115, Taiwan.
Chia-Ning
CN
Shen
†Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.|‡Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.|§Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jyh-Horng
JH
Sheu
†Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.|□Department of Chemistry and Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan.|○Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.
Shih-Hsiung
SH
Wu
D001230:Aspergillus / Q000737:chemistry*; D018360:Crystallography, X-Ray; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry* / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*; D054830:Sesterterpenes / Q000096:biosynthesis* / Q000737:chemistry*; D013624:Taiwan
D052246:Cyclooxygenase 2 Inhibitors; D008070:Lipopolysaccharides; D011753:Pyrones; D012717:Sesquiterpenes; D054830:Sesterterpenes; C000601878:yaminterritrem A; C000601879:yaminterritrem B