High serum total IgE predicts poor long-term outcome in atopic dermatitis.
Most patients with severe atopic dermatitis have elevated serum IgE levels, but there has been little research into IgE as a predictive biomarker in long-term disease outcome. The aim of this study was to evaluate the predictive value of IgE and other factors in patients with atopic dermatitis in a university clinic setting. There were 169 eligible patients (14-78 years) with a mean follow-up of 4.15 years. High baseline IgE (≥ 10,000 IU/ml) was the most important patient-related factor for a poor long-term outcome, being negatively associated with good treatment response (odds ratio (OR) 0.062, p = 0.002). Only 14.3% of patients with this high baseline IgE achieved a good treatment response in follow-up, compared with 79.7% in patients with lower (< 1,000) IgE values (p < 0.001). Serum total IgE may provide an easily measurable way to predict long-term outcome, and to help to select those patients in need of closer follow-up.
Department of Dermatology and Venereology, Helsinki University Central Hospital, Skin and Allergy Hospital, FI-00250 Helsinki, Finland. ville.kiiski@helsinki.fi.
Ville
V
Kiiski
Oskar
O
Karlsson
Anita
A
Remitz
Sakari
S
Reitamo
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D017449:Dermatitis, Allergic Contact / Q000150:complications; D003876:Dermatitis, Atopic / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
D015415:Biomarkers; D007073:Immunoglobulin E