Extended-depth spectral-domain optical coherence tomography imaging of the crystalline lens in Weill-Marchesani-like syndrome.
A 26-year-old woman presented with signs and symptoms of acute angle-closure glaucoma (ACG) in her left eye. Extended-depth spectral-domain optical coherence tomography (SD-OCT) was performed to biometrically assess the anterior chamber depth and crystalline lens conformation. Extended-depth SD-OCT imaging of the crystalline lens showed bilateral spherophakia without dislocation. Neither eye manifested a highly myopic refractive error despite spherophakia. Unanticipated conformation of the anterior and posterior lenticular curvatures, increased thickness of the crystalline lenses, and short axial lengths explained the lack of a highly myopic refractive error. These findings demonstrated a lens-related cause of the ACG. The use of extended-depth SD-OCT supported the diagnosis of subclinical Weill-Marchesani syndrome in a patient without other commonly associated findings and provided a better understanding of the mechanism of angle closure in this patient.
Ophthalmic Biophysics Center (Cabot, Ruggeri, Parel) and the Anne Bates Leach Eye Hospital (Saheb, Parrish), Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA; and the Vision Cooperative Research Center (Parel), Brien Holden Vision Institute, University of New South Wales, Sydney, Australia.
Florence
F
Cabot
Ophthalmic Biophysics Center (Cabot, Ruggeri, Parel) and the Anne Bates Leach Eye Hospital (Saheb, Parrish), Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA; and the Vision Cooperative Research Center (Parel), Brien Holden Vision Institute, University of New South Wales, Sydney, Australia.
Marco
M
Ruggeri
Ophthalmic Biophysics Center (Cabot, Ruggeri, Parel) and the Anne Bates Leach Eye Hospital (Saheb, Parrish), Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA; and the Vision Cooperative Research Center (Parel), Brien Holden Vision Institute, University of New South Wales, Sydney, Australia.
Hady
H
Saheb
Ophthalmic Biophysics Center (Cabot, Ruggeri, Parel) and the Anne Bates Leach Eye Hospital (Saheb, Parrish), Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA; and the Vision Cooperative Research Center (Parel), Brien Holden Vision Institute, University of New South Wales, Sydney, Australia.
Jean-Marie
JM
Parel
Ophthalmic Biophysics Center (Cabot, Ruggeri, Parel) and the Anne Bates Leach Eye Hospital (Saheb, Parrish), Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA; and the Vision Cooperative Research Center (Parel), Brien Holden Vision Institute, University of New South Wales, Sydney, Australia.
Richard K
RK
Parrish