Liver hydrolysate attenuates the sickness behavior induced by concanavalin A in mice.
Liver hydrolysate (LH) is used as a pharmaceutical agent in Japan, to enhance liver function. However, the effects of LH on sickness behavior are unknown. This study investigated the effect of LH on sickness behaviors, such as concanavalin A (ConA)-induced reduction of locomotor activity. ConA treatment significantly decreased locomotor activity. The striatal tyrosine hydroxylase (TH) levels were also significantly decreased following ConA treatment. The decreased locomotor activity and TH levels were significantly reversed by LH treatment. LH may prove beneficial for preventing sickness behavior following ConA treatment, at least in part, by activating TH in the striatum.
Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan. Electronic address: osamun@tohoku-pharm.ac.jp.
Osamu
O
Nakagawasai
Consumer Healthcare Products Development, Zeria Pharmaceutical Co., Ltd., Tokyo 103-8351, Japan.
Kotaro
K
Yamada
Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
Wataru
W
Nemoto
Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
Shin
S
Sato
Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
Yoshiki
Y
Ogata
Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
Kohei
K
Miya
Consumer Healthcare Products Development, Zeria Pharmaceutical Co., Ltd., Tokyo 103-8351, Japan.
Hidetomo
H
Sakurai
Department of Pharmacology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
Koichi
K
Tan-No
D000818:Animals; D003208:Concanavalin A / Q000009:adverse effects*; D003342:Corpus Striatum / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D055809:Illness Behavior / Q000187:drug effects*; D008099:Liver; D008297:Male; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D000068079:Motor Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology / Q000523:psychology*; D011492:Protein Hydrolysates / Q000494:pharmacology* / Q000627:therapeutic use*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D011492:Protein Hydrolysates; D003208:Concanavalin A; D014446:Tyrosine 3-Monooxygenase
Liver hydrolysate; Locomotor activity; Sickness behavior