Organocatalytic asymmetric C-H vinylation and arylation of N-acyl tetrahydroisoquinolines.
The first organocatalytic enantioselective oxidative C-H functionalization of N-acyl tetrahydroisoquinolines with vinyl and aryl boronates promoted by a chiral Brønsted acid is described. This metal-free process tolerates a wide range of electronically varied N-acyl tetrahydroisoquinolines and structurally diverse boronates with good to excellent enantioselectivities.
Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Xigong
X
Liu
Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Shutao
S
Sun
Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Zhilin
Z
Meng
Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Hongxiang
H
Lou
Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
Lei
L
Liu
D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D005023:Ethylene Chlorohydrin / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000737:chemistry*; D014270:Trifluoroethanol / Q000737:chemistry*
D001897:Boronic Acids; D044005:Tetrahydroisoquinolines; D014270:Trifluoroethanol; D005023:Ethylene Chlorohydrin; C005849:2,2,2-trichloroethanol