Effect of corticosteroids on facial function after cerebellopontine angle tumor removal: a double-blind study versus placebo.
The aim of this study was to assess the effect of corticosteroids administered intra- and postoperatively on the occurrence of facial palsy after a cerebellopontine angle (CPA) tumor resection, and to investigate pre- and intraoperative prognostic factors. A multicenter, prospective, randomized, double-blind and versus-placebo study was conducted between 2006 and 2010. Three hundred and ten patients operated on for a CPA tumor (96% vestibular schwannomas, 4% miscellaneous) were included by five participating centers. The population was stratified into patients with small (≤15 mm CPA on axial MRI views) and large tumors. In each group, patients were randomized to receive corticosteroid (1 mg/kg/day i.v. methylprednisolone intraoperatively and at postoperative days 1-5) or placebo. Steroids did not affect the facial function at postoperative days 1, 8 and 30 in patients with small or large tumors as evaluated by House and Brackmann grading.
Otolaryngology Department, Dijon University Hospital, Dijon, France.
Alexis
A
Bozorg Grayeli
Evelyne
E
Ferrary
Florence
F
Tubach
Isabelle
I
Bernat
Olivier
O
Deguine
Vincent
V
Darrouzet
Alain
A
Robier
Sandra
S
Zaouche
Christian
C
Dubreuil
Mathieu
M
Marx
Michel
M
Kalamarides
Bernard
B
Fraysse
Olivier
O
Sterkers
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D005158:Facial Paralysis / Q000517:prevention & control*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000601:surgery*; D011182:Postoperative Care / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control*; D055815:Young Adult
D000305:Adrenal Cortex Hormones; D005938:Glucocorticoids; D008775:Methylprednisolone