Femoral venous oxygen saturation obtained during CPR predicts successful resuscitation in a pig model.
OBJECTIVE
Central venous oxygen saturation has been shown to reflect the adequacy of tissue oxygenation during cardiopulmonary resuscitation (CPR), thereby enabling the assessment of CPR quality and the prediction of restoration of spontaneous circulation (ROSC). The femoral vein can be easily accessed during CPR. We determined if femoral venous oxygen saturation (SFVO2) values obtained during CPR could reliably predict ROSC in a pig model.


METHODS
After 15 minutes of untreated ventricular fibrillation followed by 8 minutes of basic life support, 19 pigs underwent advanced cardiovascular life support. During advanced cardiovascular life support, femoral venous blood samples were obtained at 4-minute intervals. The abilities of SFVO2 and coronary perfusion pressure (CPP) to predict ROSC were evaluated by calculating the areas under receiver operating characteristic curves (AUCs).


RESULTS
Eight pigs (42.1%) achieved ROSC. The resuscitated animals had significantly higher CPP (P < .001) and SFVO2 (P < .001) values than the nonresuscitated animals, and there was a significant correlation between SFVO2 and CPP values (r = 0.684; P < .001). The CPPs of the resuscitated and nonresuscitated animals overlapped considerably; however, there was minimal overlap between the 2 groups for SFVO2. Femoral venous oxygen saturation significantly predicted ROSC with an AUC of 0.997 (95% confidence interval, 0.911-1.000; P < .001), and it had a larger AUC than CPP (AUC, 0.964; 95% confidence interval, 0.855-0.997; P < .001). The AUC difference, however, was not statistically significant (P = .157).


CONCLUSIONS
In this study, SFVO2 values obtained during CPR exhibited a significant correlation with CPP and reliably predicted ROSC.
Department of Emergency Medicine, Songjeong Sarang Hospital, Gwangju, Republic of Korea.
Mu Jin
MJ
Kim
Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.
Kyung Woon
KW
Jeung
Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.
Byung Kook
BK
Lee
Department of Emergency Medical Service, Howon University, Gunsan, Republic of Korea.
Sung Soo
SS
Choi
Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.
Sang Wook
SW
Park
Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.
Kyung Hwan
KH
Song
Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea.
Sung Min
SM
Lee
Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Republic of Korea. Electronic address: minseofafa@naver.com.
Yong Il
YI
Min
D000818:Animals; D001784:Blood Gas Analysis; D016887:Cardiopulmonary Resuscitation; D005268:Femoral Vein; D006323:Heart Arrest / Q000097:blood / Q000628:therapy*; D008297:Male; D010100:Oxygen / Q000097:blood*; D015996:Survival Rate; D034421:Sus scrofa; D013552:Swine
D010100:Oxygen