Effects of dietary oat proteins on cholesterol metabolism of hypercholesterolaemic hamsters.
BACKGROUND
The aim of present study was to investigate the hypocholesterolaemic effects of oat proteins (OP) in hamsters fed with a hypercholesterolaemic diet. The hamsters were divided into five groups and fed with the experimental diets containing oat, OP, oat β-glucan (OG), or OP+OG for 30 days.


RESULTS
OP and the OG significantly lowered the concentrations of plasma low-density lipoprotein-cholesterol and liver total cholesterol (TC), and increased the excretion of faecal bile acid and TC. Plasma and liver TC in the OP+OG group were significantly lower than those in the OP or OG groups. Both OP and OG increased the activity of liver cholesterol 7α-hydroxylase (CYP7A1), while its activity in the OP+OG group was strongly increased compared with the OP or OG groups.


CONCLUSIONS
These results indicated that dietary OP could improve hypercholesterolaemia, while dietary OP and OG together would have better hypocholesterolaemic effects.
Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
Li-Tao
LT
Tong
Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
Lina
L
Guo
Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
Xianrong
X
Zhou
China Institute of Food and Nutrition Development, Ministry of Agriculture, 12 Zhongguancun South Street, Haidian District, Beijing 100081, China.
Ju
J
Qiu
Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
Liya
L
Liu
Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
Kui
K
Zhong
China Institute of Food and Nutrition Development, Ministry of Agriculture, 12 Zhongguancun South Street, Haidian District, Beijing 100081, China.
Sumei
S
Zhou
D000818:Animals; D000924:Anticholesteremic Agents; D018554:Avena; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008078:Cholesterol, LDL / Q000097:blood; D006224:Cricetinae; D004044:Dietary Proteins / Q000008:administration & dosage*; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008297:Male; D008647:Mesocricetus; D008517:Phytotherapy; D010940:Plant Proteins / Q000008:administration & dosage*; D047071:beta-Glucans / Q000008:administration & dosage*
D000924:Anticholesteremic Agents; D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D004044:Dietary Proteins; D010940:Plant Proteins; D047071:beta-Glucans; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase
cholesterol metabolism; hamsters; hypocholesterolaemic; oat proteins; oat β-glucan