Oxidant controlled regio- and stereodivergent azidohydroxylation of alkenes via I2 catalysis.
A novel, I2 catalyzed regio- and stereodivergent vicinal azidohydroxylation of alkenes leading to 1,2-azidoalcohols in high yields (up to 92%) and excellent dr (up to 98%) has been developed. This unprecedented transformation employs NaN3 and DMF as N- and O-nucleophiles respectively. The role of DMF as the O-source in the reaction has been unequivocally proven by (18)O labelling studies.
Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pashan Road, Pune, 411008, India. a.sudalai@ncl.res.in.
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Prasad
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Reddi
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Sudalai