A facile approach to synthesize 3,5-disubstituted-1,2,4-oxadiazoles via copper-catalyzed-cascade annulation of amidines and methylarenes.
Various 3,5-disubstituted-1,2,4-oxadiazoles are smoothly formed via copper-catalyzed cascade annulation of amidines and methylarenes. This tandem oxidation-amination-cyclization transformation represents a straightforward protocol to prepare 1,2,4-oxadiazoles from easily available starting materials, with inexpensive copper catalysts and green oxidants. It has the advantages of atom- and step-economy, good functional group tolerance, as well as operational simplicity.
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China. jianghf@scut.edu.cn.
Wei
W
Guo
Kunbo
K
Huang
Fanghua
F
Ji
Wanqing
W
Wu
Huanfeng
H
Jiang
D000578:Amidines / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000578:Amidines; D001555:Benzene Derivatives; D009942:Organometallic Compounds; D010069:Oxadiazoles; D003300:Copper