Melanotic Neuroectodermal Tumor of Infancy: A Systematic Review.
Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor, usually diagnosed within the first year of age, with a predilection for the maxilla. Although the tumor is usually benign, its rapidly growing nature and ability to cause major deformities in surrounding structures necessitate early diagnosis and intervention. It is important that medical and dental specialists are prepared to make the diagnosis and proceed with appropriate intervention. The authors performed a systematic review of the 472 reported cases from 1918 through 2013 and provided a comprehensive update on this rare entity that can have devastating effects on young patients. This investigation uncovered age at diagnosis as an important prognostic indicator, because younger age correlated with a higher recurrence rate. The authors also present a case report of a 5-month-old girl diagnosed with MNTI and review her clinical presentation and imaging and histopathologic findings.
Medical Student, Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC.
Saleh
S
Rachidi
Resident Physician, Head and Neck Tumor Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.
Amit J
AJ
Sood
Assistant Professor, Head and Neck Tumor Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.
Krishna G
KG
Patel
Associate Professor, Head and Neck Tumor Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.
Shaun A
SA
Nguyen
Assistant Professor, Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC.
Heidi
H
Hamilton
Professor, Division of Oral Pathology, Department of Stomatology, Medical University of South Carolina, Charleston, SC.
Brad W
BW
Neville
Wendy and Keith Wellin Endowed Chair in Head and Neck Surgery; Vice Chair, Clinical Affairs; Vice Chair and Director, Division of Head and Neck Oncologic Surgery; Professor and Director, Division of Head and Neck Oncology, Head and Neck Tumor Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC. Electronic address: headneck@musc.edu.
Terry A
TA
Day
D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D008441:Maxillary Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D017600:Neuroectodermal Tumor, Melanotic / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed