Setaria digitata in advancing our knowledge of human lymphatic filariasis.
Setaria digitata is a filarial parasite that causes fatal cerebrospinal nematodiasis in goats, sheep and horses, resulting in substantial economic losses in animal husbandry in the tropics. Due to its close resemblance to Wuchereria bancrofti, this nematode is also frequently used as a model organism to study human lymphatic filariasis. This review highlights numerous insights into the morphological, histological, biochemical, immunological and genetic aspects of S. digitata that have broadened our understanding towards the control and eradication of filarial diseases.
Department of Chemistry,Faculty of Science, University of Colombo,Sri Lanka.
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Perumal
Molecular Medicine Unit, Faculty of Medicine, University of Kelaniya, Ragama,Sri Lanka.
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Gunawardene
Department of Chemistry,Faculty of Science, University of Colombo,Sri Lanka.
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Dassanayake
D000818:Animals; D004605:Elephantiasis, Filarial / Q000469:parasitology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D017182:Setaria Nematode; D012719:Setariasis / Q000453:epidemiology / Q000469:parasitology* / Q000473:pathology