Ultrasensitive anion detection by NMR spectroscopy: a supramolecular strategy based on modulation of chemical exchange rate.
NMR spectroscopy is a powerful tool for monitoring molecular interactions and is widely used to characterize supramolecular systems at the atomic level. NMR is limited for sensing purposes, however, due to low sensitivity. Dynamic processes such as conformational changes or binding events can induce drastic effects on NMR spectra in response to variations in chemical exchange (CE) rate, which can lead to new strategies in the design of supramolecular sensors through the control and monitoring of CE rate. Here, we present an indirect NMR anion sensing technique in which increased CE rate, due to anion-induced conformational flexibility of a relatively rigid structure of a novel sensor, allows ultrasensitive anion detection as low as 120 nM.
Department of Environmental and Physical Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4 (Canada).|Department of Chemistry, University of Toronto, 80 St George Street, Toronto, ON M5S 3H6 (Canada).
Loïse H
LH
Perruchoud
Department of Environmental and Physical Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4 (Canada).
Alen
A
Hadzovic
Department of Environmental and Physical Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4 (Canada). xiao-an.zhang@utoronto.ca.|Department of Chemistry, University of Toronto, 80 St George Street, Toronto, ON M5S 3H6 (Canada). xiao-an.zhang@utoronto.ca.|Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4 (Canada). xiao-an.zhang@utoronto.ca.
Xiao-An
XA
Zhang
D000838:Anions / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
D000838:Anions
1H NMR spectroscopy; anion sensor; chemical exchange; hydrogen bonds; non-covalent interactions