Tumor-infiltrating T-cells: important players in clinical outcome of advanced melanoma patients.
Immune escape mechanisms are prevalent in tumors, while their influence on the potency of antitumor immunotherapy has yet to be distinguished. We recently showed that increased numbers of intratumoral T cells rather than immune-escape-mechanisms significantly correlated with clinical outcome of advanced melanoma patients to subsequent autologous tumor cell vaccination. Our data emphasize the therapeutic relevance of tumor-infiltrating T cells for the clinical outcome.
Department of Dermatology; Academic Medical Center ; University of Amsterdam ; The Netherlands.
Esther P M
EP
Tjin
Department of Dermatology; Academic Medical Center ; University of Amsterdam ; The Netherlands.
Rosalie M
RM
Luiten
clinical outcome; immune-escape mechanisms; immunotherapy; melanoma; tumor-infiltrating T-cells