Association between pre-biopsy white blood cell count and prostate biopsy - related sepsis.
BACKGROUND
Despite all preventive measures and improved biopsy techniques, serious, life-threatening complications of prostate biopsy, including sepsis, still exist. In the present study, in order to identify the risk factors that may be associated with sepsis development after prostate-biopsy, we aimed to analyze retrospectively the data of our patients who underwent transrectal ultrasound-guided prostate biopsy.


METHODS
We retrospectively reviewed the data of 889 patients who underwent prostate biopsy at our clinic. We compared pre-biopsy parameters (age, prostate volume, white blood cell (WBC) count, fasting blood glucose, free and total prostate specific antigen levels) between patients who developed sepsis and those who were sepsis-free following prostate biopsy.


RESULTS
28 patients (3.1%) developed sepsis. Among the risk factors evaluated, only pre-biopsy WBC count was found to be a significant risk factor for biopsy-related sepsis. A 5.1 fold increase was detected in the risk for sepsis development, when the cut-off value of WBC was accepted as 11.165/μL, OR: 5.1 (95% CI: 2.3-11.5). The post-biopsy sepsis development rate in patients with pre-biopsy WBC count greater and less than 11.165/μL was 13.7% (n = 10) and 3% (n = 18) respectively.


CONCLUSIONS
Patients with a pre-biopsy WBC count greater than 11.165/μL should be informed of the increased risk of developing post-biopsy sepsis.
Ankara Numune Education and Research Hospital, Department of Urology, Ankara, Turkey.
Suleyman
S
Bulut
Ankara Numune Education and Research Hospital, Department of Urology, Ankara, Turkey.
Binhan Kagan
BK
Aktas
Ankara Numune Education and Research Hospital, Department of Urology, Ankara, Turkey.
Cevdet Serkan
CS
Gokkaya
Ankara Numune Education and Research Hospital, Department of Urology, Ankara, Turkey.
Alp Ozgur
AO
Akdemir
Ankara Numune Education and Research Hospital, Department of Urology, Ankara, Turkey.
Akif Ersoy
AE
Erkmen
Ankara Numune Education and Research Hospital, Department of Urology, Ankara, Turkey.
Mehmet
M
Karabakan
Ankara Numune Education and Research Hospital, Department of Urology, Ankara, Turkey.
Ali
A
Memis
biopsy; leukocytosis; prostate; sepsis