Association of 42 SNPs with genetic risk for cervical cancer: an extensive meta-analysis.
BACKGROUND
A large number of single nucleotide polymorphisms (SNPs) associated with cervical cancer have been identified through candidate gene association studies and genome-wide association studies (GWAs). However, some studies have yielded different results for the same SNP. To obtain a more comprehensive understanding, we performed a meta-analysis on previously published case-control studies involving the SNPs associated with cervical cancer.


METHODS
Electronic searches of PubMed and Embase were conducted for all publications about the association between gene polymorphisms and cervical cancer. One-hundred and sixty-seven association studies were included in our research. For each SNP, three models (the allele, dominant and recessive effect models) were adopted in the meta-analysis. For each model, the effect summary odds ratio (OR) and 95% CI were calculated. Heterogeneity between studies was evaluated by Cochran's Q test. If the p value of Q test was less than 0.01, a random effect model was used; otherwise, a fixed effect model was used.


RESULTS
The results of our meta-analysis showed that: (1) There were 8, 2 and 8 SNPs that were significantly associated with cervical cancer (P < 0.01) in the allele, dominant and recessive effect models, respectively. (2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical cancer in the allele effect model (1.83[1.57, 2.13]); in addition, rs1048943 (CYP1A1 A4889G) had a very strong association in the dominant and recessive effect model. (3) 15, 11 and 10 SNPs had high heterogeneity (P < 0.01) in the three models, respectively. (4) There was no published bias for most of the SNPs according to Egger's test (P < 0.01) and Funnel plot analysis. For some SNPs, their association with cervical cancer was only tested in a few studies and, therefore, might have been subjected to published bias. More studies on these loci are required.


CONCLUSIONS
Our meta-analysis provides a comprehensive evaluation of cervical cancer association studies.
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. colombo2008@sina.com.
Shaoshuai
S
Wang
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. 1377611095@qq.com.
Haiying
H
Sun
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. linda.jia@163.com.
Yao
Y
Jia
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. tfx19870521@sina.com.
Fangxu
F
Tang
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. zhouhang19861004@163.com.
Hang
H
Zhou
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. hustlxx@qq.com.
Xiong
X
Li
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. 405818556@qq.com.
Jin
J
Zhou
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. 365000619@qq.com.
Kecheng
K
Huang
Department of Gynecology & Obstetrics, the Central Hospital of Wuhan, Wuhan, 430032, P.R. China. zhangqh66@qq.com.
Qinghua
Q
Zhang
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. cat_huting@163.com.
Ting
T
Hu
Department of Obstetrics tumor, The tumor hospital of henan province, Zhengzhou, 450008, P.R. China. doctoryr@126.com.
Ru
R
Yang
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. tjwcy@yahooo.com.cn.
Changyu
C
Wang
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. lindaxi02@yahoo.com.cn.
Ling
L
Xi
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. dr.deng@tjh.tjmu.edu.cn.
Dongrui
D
Deng
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. huit71@sohu.com.
Hui
H
Wang
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. sxwang@tjh.tjmu.edu.cn.
Shixuan
S
Wang
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. dma@tjh.tjmu.edu.cn.
Ding
D
Ma
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 jiefang road, Wuhan, 430030, P.R. China. lee5190008@126.com.
Shuang
S
Li
D000483:Alleles; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015233:Models, Statistical; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D002583:Uterine Cervical Neoplasms / Q000235:genetics*