Are red gourami (Colisa labiosa) low xenobiotic metabolizers? Elucidation of in vivo pharmacokinetics of pyrene as a model substrate.
Red gourami (Colisa labiosa) have previously been shown to have low levels of pyrene-metabolizing activity. In this study, other pharmacokinetic factors of pyrene in C. labiosa were compared to those in Japanese medaka (Oryzias latipes). Results indicated that the two species labiosa absorbed pyrene in similar amounts. However, excretion of pyrene metabolites from C. labiosa over an 8-day period was lower than those from O. latipes. These findings show that C. labiosa has low ability to metabolize pyrene and to excrete pyrene and its metabolites from the body, and is therefore considered an accumulator of these chemicals. C. labiosa has unique characteristics with regard to pyrene pharmacokinetics. Knowledge about interspecies differences in pharmacokinetics is crucial in determining the endangered species to xenobiotic exposure.
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan; Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa. Electronic address: y_ikenaka@vetmed.hokudai.ac.jp.
Yoshinori
Y
Ikenaka
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan.
Shouta M M
SM
Nakayama
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan.
Mami
M
Oguri
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Thailand.
Aksorn
A
Saengtienchai
Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan.
Hazuki
H
Mizukawa
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Japan.
Jun
J
Kobayashi
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan; Food Control Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Wageh Sobhy
WS
Darwish
Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Japan.
Mayumi
M
Ishizuka
D000818:Animals; D008956:Models, Chemical; D009990:Oryzias / Q000378:metabolism*; D010473:Perciformes / Q000378:metabolism*; D011721:Pyrenes / Q000493:pharmacokinetics*; D013045:Species Specificity; D015262:Xenobiotics / Q000493:pharmacokinetics
D011721:Pyrenes; D015262:Xenobiotics; C030984:pyrene
Colisa labiosa; Oryzias latipes; Pharmacokinetics; Pyrene; Xenobiotic