miR-210, a modulator of hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cell.
miR-210 has been found consistently induced by hypoxia and implicated in cancer progression. Despite widespread exploration on miR-210 function, little is known about its action on invasion and metastasis of ovarian cancer. In this study, miR-210 was induced by hypoxia in SKOV3 ovarian cancer cells and then suppressed with its specific inhibitor. Repression of miR-210 in hypoxic cells led to upregulation of E-cadherin, downregulation of vimentin and Snail, and attenuation of wound healing capability. On the other hand, miR-210 was overexpressed in normoxic SKOV3 cells, which resulted in decrease of E-cadherin, increase of vimentin and Snail, and facilitation of wound healing capability. These results revealed that miR-210 promoted ovarian cancer cell mobility by acting as a modulator of epithelial-mesenchymal transition (EMT), highlighting the importance of miR-210 in ovarian cancer progression.
Center for Translational Medicine, First Affiliated Hospital, Xi'an Jiaotong University College of Medicine Xi'an, P.R. China.
Lu
L
Ding
Center for Translational Medicine, First Affiliated Hospital, Xi'an Jiaotong University College of Medicine Xi'an, P.R. China.
Le
L
Zhao
Center for Laboratory Medicine, First Affiliated Hospital, Xi'an Jiaotong University College of Medicine Xi'an, P.R. China.
Wei
W
Chen
Center for Translational Medicine, First Affiliated Hospital, Xi'an Jiaotong University College of Medicine Xi'an, P.R. China.
Ting
T
Liu
Center for Translational Medicine, First Affiliated Hospital, Xi'an Jiaotong University College of Medicine Xi'an, P.R. China.
Zhen
Z
Li
Center for Translational Medicine, First Affiliated Hospital, Xi'an Jiaotong University College of Medicine Xi'an, P.R. China.
Xu
X
Li
epithelial-mesenchymal transition; miR-210; ovarian cancer