Stem cell therapy for bronchopulmonary dysplasia: bench to bedside translation.
Bronchopulmonary dysplasia (BPD), a chronic lung disease affecting very premature infants, is a major cause of mortality and long-term morbidities despite of current progress in neonatal intensive care medicine. Though there has not been any effective treatment or preventive strategy for BPD, recent stem cell research seems to support the assumption that stem cell therapy could be a promising and novel therapeutic modality for attenuating BPD severity. This review summarizes the recent advances in stem cell research for treating BPD. In particular, we focused on the preclinical data about stem cell transplantation to improve the lung injury using animal models of neonatal BPD. These translational research provided the data related with the safety issue, optimal type of stem cells, optimal timing, route, and dose of cell transplantation, and potency marker of cells as a therapeutic agent. Those are essential subjects for the approval and clinical translation. In addition, the successful phase I clinical trial results of stem cell therapies for BPD are also discussed.
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
So Yoon
0000-0002-1821-3173
SY
Ahn
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Yun Sil
0000-0001-9201-2938
YS
Chang
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Won Soon
0000-0002-8245-4692
WS
Park
D001997:Bronchopulmonary Dysplasia / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy; D002986:Clinical Trials as Topic; D005312:Fetal Blood / Q000166:cytology / Q000637:transplantation; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology
Bronchopulmonary Dysplasia; Cell Transplantation; Infant, Premature; Mesenchymal Stem Cells