Three new iridoids from leaves of Cornus officinalis.
Three new iridoids, cornifins A-C (1-3), together with a known iridoid, were obtained from EtOAc layer of leaves of Cornus officinalis. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses. Compound 2 showed weak inhibitory activity against lung cancer cell line A-549 with IC50 value of 29.1 μM.
a Life School of Science and Technology, Henan Institute of Science and Technology , Xinxiang 453003 , China.
Yong-Chao
YC
Li
Jing
J
Yang
Xing-Gang
XG
Wu
Xin-Juan
XJ
Xu
Qing-Yun
QY
Fu
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029768:Cornus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D039823:Iridoids; C000602474:cornifin A iridoid; C000602475:cornifin B iridoid; C000602476:cornifin C iridoid
Cornaceae; Cornus officinalis; cornifins A–C; iridoids; structure and cytotoxicity