High-grade invasive urothelial carcinoma of the ureter with systematic lymph node metastasis successfully treated by nephroureterectomy followed by chemotherapy.
We report a case of high-grade invasive urothelial carcinoma with squamous differentiation of the urinary tract. A 72-year-old woman was referred to our hospital because of asymptomatic gross hematuria. A right-sided laparoscopic radical nephroureterectomy with bladder cuff removal and right-sided pelvic lymphadenectomy were performed at our institution. Postoperative pathological examination showed high-grade urothelial carcinoma with squamous differentiation. Five months later, CT scan of the neck diagnosed it as lymph nodes metastasis. Following the laparoscopic radical nephroureterectomy, chemotherapy with gemcitabine and cisplatin or nedaplatin was carried out. After several cycles' chemotherapy, nearly all the enlarged lymph node disappeared. Seven years and five years passed, urothelial carcinoma has not recurred after the surgery and all the lymph node disappeared respectively.
Department of Medical Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine Shanghai 200072, China.
Zhu-Qing
ZQ
Liu
Department of Medical Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine Shanghai 200072, China.
Xi
X
Zhang
Department of Medical Oncology, Shanghai Tenth People's Hospital, Tongji University, School of Medicine Shanghai 200072, China.
Qing
Q
Xu
Chemotherapy; lymph nodes metastasis; ureteral urothelial carcinoma