Detection of Mycoplasma genitalium from male primary urine specimens: an epidemiologic dichotomy with Trichomonas vaginalis.
A total of 2750 male urines subjected to a transcription-mediated amplification (TMA)-based Mycoplasma genitalium assay yielded 188 positive results (6.84%). This rate was similar to Chlamydia trachomatis (6.87%; P = 0.96) and greater than Neisseria gonorrhoeae (4.0%) and Trichomonas vaginalis (2.3%; P < 0.0002). Mean age of M. genitalium-infected males (30.8) was similar to N. gonorrhoeae (P = 0.78) but less than T. vaginalis (mean, 41.6; P < 0.0001). A total of 266 STI clinic encounters had at least 1 sexually transmitted infection (STI); 36.5% of these encounters had sole detection of M. genitalium (P ≤ 0.009 versus sole detection of other STI agents). In 209 community encounters with at least 1 STI, 22.0% exhibited sole detection of M. genitalium (P = 0.0007 versus sole M. genitalium detection in STI clinic males), while 18.7% had sole detection of T. vaginalis (P < 0.0002 versus detection in STI clinic males). TMA-based M. genitalium screening identifies additional cases of nongonococcal urethritis.
Wheaton Franciscan Laboratory, Milwaukee, WI, USA, 53215.
Maureen
M
Napierala
Wheaton Franciscan Laboratory, Milwaukee, WI, USA, 53215; College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA, 53201. Electronic address: Erik.Munson@wfhc.org.
Erik
E
Munson
Holton Street Clinic, Milwaukee, WI, USA, 53212.
David
D
Wenten
Holton Street Clinic, Milwaukee, WI, USA, 53212.
Paula
P
Phipps
Holton Street Clinic, Milwaukee, WI, USA, 53212.
Roger
R
Gremminger
Holton Street Clinic, Milwaukee, WI, USA, 53212.
Mary Kay
MK
Schuknecht
Wheaton Franciscan Laboratory, Milwaukee, WI, USA, 53215.
Kimber L
KL
Munson
Wheaton Franciscan Laboratory, Milwaukee, WI, USA, 53215.
Vivian
V
Boyd
Wheaton Franciscan Laboratory, Milwaukee, WI, USA, 53215; Holton Street Clinic, Milwaukee, WI, USA, 53212.
Deb
D
Hamer
Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison, WI, USA, 53706; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA, 53706.
Ronald F
RF
Schell
Wheaton Franciscan Laboratory, Milwaukee, WI, USA, 53215.
Jeanne E
JE
Hryciuk
D000293:Adolescent; D000328:Adult; D000368:Aged; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques / Q000379:methods; D045704:Mycoplasma genitalium / Q000302:isolation & purification*; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D015995:Prevalence; D012749:Sexually Transmitted Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology / Q000469:parasitology; D014246:Trichomonas vaginalis / Q000302:isolation & purification; D014526:Urethritis / Q000175:diagnosis* / Q000453:epidemiology* / Q000382:microbiology / Q000469:parasitology; D014556:Urine / Q000382:microbiology*; D055815:Young Adult
Males; Mycoplasma genitalium; Sexually transmitted infection; Transcription-mediated amplification; Trichomonas vaginalis