Calorimetric evidence of interaction of brominated flame retardants with membrane model.
The presence of polybrominated flame retardants in the environment seems to be increasing in the past decade. Considering the toxic effects of these pollutants, it is important evaluating the potential interaction with biological membranes for a risk assessment. In this study low and high brominated biphenyls and biphenyl ethers were used to investigate their interaction with biological membrane models constituted by liposomes, using differential scanning calorimetry (DSC) technique. The medium influence on membrane absorption was also assessed. The findings indicate that membrane interaction is controlled by compound structural characteristics. The membrane absorption is allowed by lipophilic medium; instead hydrophilic medium prevents membrane permeation.
Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, Catania 95125, Italy.
Vito
V
Librando
Dipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Campus Universitario "S. Venuta", Viale S. Venuta, Germaneto, CZ 88100, Italy.
Maria Lorena
ML
Accolla
Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, Catania 95125, Italy.
Zelica
Z
Minniti
Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, Catania 95125, Italy.
Matteo
M
Pappalardo
Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 6, Catania 95125, Italy.
Francesco
F
Castelli
Dipartimento di Anatomia, Biologia e Genetica, Medicina Legale, Neuroscienze, Patologia Diagnostica, Igiene e SanitàPubblica (G. F. Ingrassia), Università degli Studi di Catania, Via S. Sofia 87, 95123 Catania, Italy.
Orazio
O
Cascio
Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 6, Catania 95125, Italy. Electronic address: vlibrando@unict.it.
Maria Grazia
MG
Sarpietro
D065966:Absorption, Physicochemical; D002152:Calorimetry, Differential Scanning / Q000379:methods*; D004785:Environmental Pollutants / Q000032:analysis; D005411:Flame Retardants / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D008567:Membranes, Artificial; D010647:Phenyl Ethers / Q000737:chemistry / Q000378:metabolism; D011075:Polybrominated Biphenyls / Q000737:chemistry / Q000378:metabolism*
D004785:Environmental Pollutants; D005411:Flame Retardants; D008081:Liposomes; D008563:Membrane Lipids; D008567:Membranes, Artificial; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls
BB-15; BB-209; BDE-15; BDE-209; Biomembrane model; Polybrominated flame retardants