Anti-inflammatory anthraquinones from the crinoid Himerometra magnipinna.
Chemical investigation of a crinoid Himerometra magnipinna has afforded three anthraquinones (1-3), including one new metabolite, (+)-rhodoptilometrin (1). The structures of these compounds were elucidated on the basis of their spectroscopic data and the absolute configuration of 1 was further confirmed by single-crystal X-ray diffraction analysis. In the in vitro anti-inflammatory effects test, compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells.
Yen-You
YY
Lin
Su-June
SJ
Tsai
Michael Y
MY
Chiang
Zhi-Hong
ZH
Wen
Jui-Hsin
JH
Su
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D004447:Echinodermata / Q000737:chemistry*; D015394:Molecular Structure
D000880:Anthraquinones; D000893:Anti-Inflammatory Agents