Anxiolytic-Like Effects of 7H-Benzo[e]perimidin-7-One Derivatives through Elevated Plus-Maze Test in Mice.
Anxiety is one of the behavior disorders that has been studied more together with depression in the world, and that has enormous interference in the mental health of the affected patients. The states of panic and phobia are a part of the psychological characteristics that some drugs have tried to control though with varied side effects that are proven to be difficult to control. The use of perimidinone derivatives against the effects of anxiety has generated that A5 is the most active and selective anxiolytic compound, differing with regard to diazepam (DZP) used as control reference in elevated plus-maze (EPM) test. This test allows to conclude that it is feasible to differentiate the use selective as anxiolytic or antidepressant of certain perimidinones, because A4 had been characterized by our research group as an important antidepressant respect to A5 studied in previous reports.
Jorge
J
Nunez
Jose A
JA
Fontenla
Seyed Mohammad
SM
Nabavi
Eugenio
E
Uriarte
Alejandra
A
Herrera
Laboratory of Pharmaceutical Chemistry, Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain. esobarzo@gmail.com.
Eduardo
E
Sobarzo-Sanchez
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000737:chemistry* / Q000494:pharmacology*; D001007:Anxiety / Q000188:drug therapy*; D001522:Behavior, Animal / Q000187:drug effects; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure
D000470:Alkaloids; D014151:Anti-Anxiety Agents