Dual Inhibition And Monitoring Of Beta-amyloid Fibrillation By A Luminescent Iridium(III) Complex.
In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer's disease diagnosis and treatment.
Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong, China. acywong@cityu.edu.hk.
Chun-Yuen
CY
Wong
Lai-Hon
LH
Chung
Lihua
L
Lu
Modi
M
Wang
Bingyong
B
He
Li-Juan
LJ
Liu
Chung-Hang
CH
Leung
Dik-Lung
DL
Ma
D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy; D000682:Amyloid / Q000187:drug effects* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D007495:Iridium / Q000737:chemistry* / Q000494:pharmacology*; D008163:Luminescent Measurements / Q000379:methods; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology*; D010446:Peptide Fragments / Q000378:metabolism*
D000682:Amyloid; D016229:Amyloid beta-Peptides; D018696:Neuroprotective Agents; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D007495:Iridium