Alkylamides of Acmella oleracea.
Phytochemical investigation of the flowers of Acmella oleracea had resulted in the isolation of one new alkylamide, (2E,5Z)-N-isobutylundeca-2,5-diene-8,10-diynamide (1), together with four known analogues (2-5). The structures of these compounds were determined by the interpretation of spectroscopic methods, especially NMR technologies (COSY, HSQC, HMBC, and NOESY). In addition, a convenient method for concentrating the alkylamide-rich fraction and analyzing fingerprint profile of A. oleracea was established.
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. jmb@kmu.edu.tw.|Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan. jmb@kmu.edu.tw.
Yuan-Bin
YB
Cheng
School of Nutrition, College of Health Care and Management, Chung Shan Medical University, Taichung 40201, Taiwan. rhl@csmu.edu.tw.
Rosa Huang
RH
Liu
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. usa19871216@yahoo.com.tw.
Meng-Chi
MC
Ho
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Kuma0401@gmail.com.|Chinese Herbal Medicine Research Center, China Medical University, Taichung 404, Taiwan. Kuma0401@gmail.com.
Tung-Ying
TY
Wu
Department of Physical Therapy, Tzu-Hui Institute of Technology, Pingtung 926, Taiwan. chingyeu1971@yahoo.com.tw.
Ching-Yeu
CY
Chen
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. iwenlo99@gmail.com.
I-Wen
IW
Lo
Translational Research Center and Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. mifeho@kmu.edu.tw.
Ming-Feng
MF
Hou
Translational Research Center and Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. yuanssf@ms33.hinet.net.
Shyng-Shiou
SS
Yuan
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.|School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.|Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
Yang-Chang
YC
Wu
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.|Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.|Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan. aaronfrc@kmu.edu.tw.|Research Center for Natural Product & Drug Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.
Fang-Rong
FR
Chang
D000577:Amides / Q000737:chemistry*; D019659:Asteraceae / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*
D000577:Amides; D010936:Plant Extracts