[Physiological properties of the vancomycin-resistant strain Staphylococcus epidermidis 33 GISK VAN(R)].
Physiological properties of a selected Staphylococcus epidermidis strain 33 GISK VAN(R) with high resistance to vancomycin, multiple resistance to various antibiotics, as well as decreased sensitivity to lysozyme, lysostaphin, and the low-molecular mass peptide warnerin were studied. The strain was characterized by a thicker cell wall, resulting in considerably decreased rates of vancomycin penetration into the cells and in limited access of the antibiotic to its targets on the bacterial membrane.
L I
LI
Kononova
V P
VP
Korobov
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001430:Bacteriocins / Q000494:pharmacology; D001692:Biological Transport; D002473:Cell Wall / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D024901:Drug Resistance, Multiple, Bacterial / Q000502:physiology*; D008248:Lysostaphin / Q000494:pharmacology; D018625:Microscopy, Atomic Force; D009113:Muramidase / Q000494:pharmacology; D010539:Permeability; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D014640:Vancomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; C542625:Warnerin; D014640:Vancomycin; D009113:Muramidase; D008248:Lysostaphin