Impact of age-related socio-economic and clinical determinants of quality of life among long-term breast cancer survivors.
OBJECTIVE
The main purpose of this study was to identify age-related socioeconomic and clinical determinants of quality of life among breast cancer survivors five years after the diagnosis. The secondary objective was to describe quality of life in the studied population according to age.


METHODS
A cross-sectional survey in five-year breast cancer survivors was conducted in women diagnosed with breast cancer in 2007 and 2008 in Côte d'Or.


METHODS
Quality of life was assessed with the SF-12, the EORTC-QLQ-C30 and the EORTC-QLQ-BR23 questionnaires. Socio-economic deprivation was assessed by the EPICES questionnaire. Social support was assessed by the Sarason questionnaire and clinical features were collected through the Côte d'Or breast cancer registry. Age-related determinants of quality of life were identified using multivariate mixed model analysis for each SF-12 dimension.


RESULTS
Overall 396 women completed the questionnaires. Women aged <65 years had a better quality of life and a greater availability of social support than did women aged ≥65 years. Body mass index, relapse and EPICES were found to be determinants of quality of life in younger women (p<0.006). For older women, comorbidities and EPICES deprivation scores were predictors of low quality of life scores (p<0.006).


CONCLUSIONS
Five years after breast cancer diagnosis, disease severity did not affect quality of life. The major determinants of quality of life in younger women were disease relapse and EPICES deprivation scores while those in older women were comorbidities and EPICES deprivation scores.
Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion BP 77980, 21079 Dijon Cedex, France; EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France.
Pegdwende Olivia
PO
Dialla
Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion BP 77980, 21079 Dijon Cedex, France; EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France.
Wai-On
WO
Chu
Pathology Centre, 33 rue Nicolas Bornier, 21000 Dijon, France.
Patrick
P
Roignot
Centre Radiotherapie du Parc, 18 cours du General de Gaulle, 21000 Dijon Cedex, France.
Marie-Christine
MC
Bone-Lepinoy
Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion BP 77980, 21079 Dijon Cedex, France; EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France.
Marie-Laure
ML
Poillot
Department of Surgical Oncology, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion BP 77980, 21079 Dijon Cedex, France.
Charles
C
Coutant
Breast and Gynaecologic Cancer Registry of Côte d'Or, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion BP 77980, 21079 Dijon Cedex, France; EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France.
Patrick
P
Arveux
EA 4184, Faculty of Medicine, University of Burgundy, Dijon, France; Biostatistics and Quality of Life Unit, Centre Georges François Leclerc Comprehensive Cancer Centre, 1 rue Professeur Marion BP 77980, 21079 Dijon Cedex, France; National Quality of Life in Oncology Platform, France. Electronic address: sdabakuyo@cgfl.fr.
Tienhan Sandrine
TS
Dabakuyo-Yonli
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000523:psychology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000523:psychology*; D011203:Poverty / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012944:Social Support; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D017741:Survivors / Q000523:psychology*
Age; Breast cancer survivors; Quality of life; Social support; Socio-economic status