Influence of the Component Excipients on the Quality and Functionality of a Transdermal Film Formulation.
The influence of formulation variables, i.e., a hydrophilic polymer (Methocel(®) E15) and a film-forming polymer (Eudragit(®) RL 100 and Eudragit(®) RS 100), on the physicochemical and functional properties of a transdermal film formulation was assessed. Several terpenes were initially evaluated for their drug permeation enhancement effects on the transdermal film formulations. D-Limonene was found to be the most efficient permeation enhancer among the tested terpenes. Transdermal film formulations containing granisetron (GRN) as a model drug, D-limonene as a permeation enhancer, and different ratios of a hydrophilic polymer (Methocel(®) E15) and a film-forming polymer (Eudragit(®) RL 100 or Eudragit(®) RS 100) were prepared. The prepared films were evaluated for their physicochemical properties such as weight variation, thickness, tensile strength, folding endurance, elongation (%), flatness, moisture content, moisture uptake, and the drug content uniformity. The films were also evaluated for the in vitro drug release and ex vivo drug permeation. The increasing ratios of Methocel(®):Eudragit(®) polymers in the formulation linearly and significantly increased the moisture content, moisture uptake, water vapor transmission rate (WVTR), and the transdermal flux of GRN from the film formulations. Increasing levels of Methocel(®) in the formulations also increased the rate and extent of the GRN release and the GRN permeation from the prepared films.
Department of Pharmaceutical Sciences, R. T. M. Nagpur University, Nagpur, India.
Suprit D
SD
Saoji
Vidyabharati College of Pharmacy, Amravati, India.
Sandip C
SC
Atram
Department of Pharmaceutical Sciences, R. T. M. Nagpur University, Nagpur, India.
Pradip W
PW
Dhore
G. S. Tompe College, Chandurbazar, Amravati, India.
Priya S
PS
Deole
Department of Pharmaceutical Sciences, R. T. M. Nagpur University, Nagpur, India.
Nishikant A
NA
Raut
St. John Fisher College, Wegmans School of Pharmacy, 3690 East Avenue, Rochester, New York, 14618, USA. viveksdave@gmail.com.
Vivek S
VS
Dave
D000269:Adhesives / Q000737:chemistry*; D000279:Administration, Cutaneous; D002626:Chemistry, Pharmaceutical / Q000379:methods; D053138:Cyclohexenes / Q000737:chemistry; D065546:Drug Liberation; D005079:Excipients / Q000737:chemistry*; D017829:Granisetron / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D000077222:Limonene; D008747:Methylcellulose; D010539:Permeability; D011108:Polymers / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D013718:Tensile Strength; D013729:Terpenes / Q000737:chemistry; D057968:Transdermal Patch
D000269:Adhesives; D053138:Cyclohexenes; D005079:Excipients; D017829:Granisetron; D000077222:Limonene; D008747:Methylcellulose; D011108:Polymers; D011109:Polymethacrylic Acids; D013729:Terpenes; C038300:methylmethacrylate-methacrylic acid copolymer
film-forming polymers; hydrophilic polymers; permeation enhancers; transdermal films