Functional Connectivity in MRI Is Driven by Spontaneous BOLD Events.
Functional brain signals are frequently decomposed into a relatively small set of large scale, distributed cortical networks that are associated with different cognitive functions. It is generally assumed that the connectivity of these networks is static in time and constant over the whole network, although there is increasing evidence that this view is too simplistic. This work proposes novel techniques to investigate the contribution of spontaneous BOLD events to the temporal dynamics of functional connectivity as assessed by ultra-high field functional magnetic resonance imaging (fMRI). The results show that: 1) spontaneous events in recognised brain networks contribute significantly to network connectivity estimates; 2) these spontaneous events do not necessarily involve whole networks or nodes, but clusters of voxels which act in concert, forming transiently synchronising sub-networks and 3) a task can significantly alter the number of localised spontaneous events that are detected within a single network. These findings support the notion that spontaneous events are the main driver of the large scale networks that are commonly detected by seed-based correlation and ICA. Furthermore, we found that large scale networks are manifestations of smaller, transiently synchronising sub-networks acting dynamically in concert, corresponding to spontaneous events, and which do not necessarily involve all voxels within the network nodes oscillating in unison.
Sir Peter Mansfield Imagaing Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Thomas W
TW
Allan
Sir Peter Mansfield Imagaing Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Susan T
ST
Francis
Basque Center on Cognition, Brain and Language, Donostia-San Sebastian, Spain.
Cesar
C
Caballero-Gaudes
Sir Peter Mansfield Imagaing Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Peter G
PG
Morris
Institute of Mental Health, University of Nottingham, Jubilee Campus, Nottingham, United Kingdom.
Elizabeth B
EB
Liddle
Institute of Mental Health, University of Nottingham, Jubilee Campus, Nottingham, United Kingdom.
Peter F
PF
Liddle
Sir Peter Mansfield Imagaing Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Matthew J
MJ
Brookes
Sir Peter Mansfield Imagaing Centre, School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom.
Penny A
PA
Gowland
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D001931:Brain Mapping; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood*; D011859:Radiography; D055815:Young Adult
D010100:Oxygen