Gd-Complexes of New Arylpiperazinyl Conjugates of DTPA-Bis(amides): Synthesis, Characterization and Magnetic Relaxation Properties.
Two new DTPA-bis(amide) based ligands conjugated with the arylpiperazinyl moiety were synthesized and subsequently transformed into their corresponding Gd(III) complexes 1 and 2 of the type [Gd(L)H2O]·nH2O. The relaxivity (R1) of these complexes was measured, which turned out to be comparable with that of Omniscan®, a commercially available MRI contrast agent. The cytotoxicity studies of these complexes indicated that they are non-toxic, which reveals their potential and physiological suitability as MRI contrast agents. All the synthesized ligands and complexes were characterized with the aid of analytical and spectroscopic methods, including elemental analysis, 1H-NMR, FT-IR, XPS and fast atom bombardment (FAB) mass spectrometry.
Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia. abdullahbasalem@gmail.com.
Abdullah O
AO
Ba-Salem
Chemistry Department, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia. nullah@kfupm.edu.sa.
Nisar
N
Ullah
Center of Research Excellence in Nanotechnology, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia. mnshaikh@kfupm.edu.sa.
M Nasiruzzaman
MN
Shaikh
Physics Department, King Fahd University of Petroleum and Minerals, Dhahran-31261, Saudi Arabia. mmfaiz@kfupm.edu.sa.
Mohamed
M
Faiz
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. zaheer_qasmi@hotmail.com.
Zaheer
Z
Ul-Haq
D016475:3T3 Cells; D000577:Amides; D000818:Animals; D002460:Cell Line; D003287:Contrast Media / Q000008:administration & dosage; D005682:Gadolinium / Q000008:administration & dosage* / Q000737:chemistry*; D019786:Gadolinium DTPA / Q000008:administration & dosage* / Q000737:chemistry*; D008024:Ligands; D008279:Magnetic Resonance Imaging; D051379:Mice; D004369:Pentetic Acid / Q000008:administration & dosage* / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014867:Water / Q000737:chemistry
D000577:Amides; D003287:Contrast Media; D008024:Ligands; D014867:Water; D004369:Pentetic Acid; C064925:gadodiamide; D005682:Gadolinium; D019786:Gadolinium DTPA