Bioinformatics analysis of potential essential genes that response to the high intraocular pressure on astrocyte due to glaucoma.
OBJECTIVE
To study the gene expression response and predict the network in cell due to pressure effects on optic nerve injury of glaucoma.


METHODS
We used glaucoma related microarray data in public database [Gene Expression Omnibus (GEO)] to explore the potential gene expression changes as well as correspondent biological process alterations due to increased pressure in astrocytes during glaucoma development.


RESULTS
A total of six genes were identified to be related with pressure increasing. Through the annotation and network analysis, we found these genes might be involved in cell morphological remodeling, angiogenesis, mismatch repair.


CONCLUSIONS
Increasing pressure in glaucoma on astrocytes might cause gene expression alterations, which might induce some cellular responses changes.
Department of Ophthalmology, China Medical University, Shengjing Hospital, Shenyang 110004, Liaoning Province, China.
Yang
Y
Yang
Department of Orthopedics, China Medical University, Shengjing Hospital, Shenyang 110004, Liaoning Province, China.
Jing-Zhu
JZ
Duan
Department of Ophthalmology, China Medical University, Shengjing Hospital, Shenyang 110004, Liaoning Province, China.
Yu
Y
Di
Department of Ophthalmology, China Medical University, Shengjing Hospital, Shenyang 110004, Liaoning Province, China.
Dong-Mei
DM
Gui
Department of Ophthalmology, China Medical University, Shengjing Hospital, Shenyang 110004, Liaoning Province, China.
Dian-Wen
DW
Gao
astrocytes; glaucoma; high intraocular pressure; microarray