What Is the Added Benefit of Oropharyngeal Swabs Compared to Nasal Swabs Alone for Respiratory Virus Detection in Hospitalized Children Aged <10 Years?
We evaluated the added value of collecting both nasal and oropharyngeal swabs, compared with collection of nasal swabs alone, for detection of common respiratory viruses by reverse transcription-polymerase chain reaction in hospitalized children aged <10 years. Nasal swabs had equal or greater sensitivity than oropharyngeal swabs for detection of respiratory syncytial virus, adenovirus, human metapneumovirus, rhinovirus, and influenza virus but not parainfluenza virus. The addition of an oropharyngeal swab, compared with use of a nasal swab alone, increased the frequency of detection of each respiratory virus by no more than 10% in children aged <10 years.
Influenza Division.
Fatimah S
FS
Dawood
Centro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City.
Jorge
J
Jara
Hospital Del Niño.
Dora
D
Estripeaut
Hospital Del Niño.
Ofelina
O
Vergara
Hospital De Especialidades Pediátricas Omar Torrijos.
Kathia
K
Luciani
Hospital De Especialidades Pediátricas Omar Torrijos.
Mary
M
Corro
Hospital Materno Infantil José Domingo De Obaldía, David, Panama.
Tirza
T
de León
Hospital Materno Infantil José Domingo De Obaldía, David, Panama.
Ricardo
R
Saldaña
Hospital San Juan De Dios, Santa Ana.
Juan Miguel
JM
Castillo Baires
Hospital San Juan De Dios, Santa Ana.
Rafael
R
Rauda Flores
Hospital San Juan De Dios, San Miguel, El Salvador.
Rafael A
RA
Cazares
Hospital San Juan De Dios, San Miguel, El Salvador.
Yarisa Sujey
YS
Brizuela de Fuentes
Gorgas Memorial Institute for Health Studies, Panama City.
Danilo
D
Franco
Gorgas Memorial Institute for Health Studies, Panama City.
Melissa
M
Gaitan
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Eileen
E
Schneider
Influenza Division.
LaShondra
L
Berman
Influenza Division.
Eduardo
E
Azziz-Baumgartner
Influenza Division.
Marc-Alain
MA
Widdowson
D002648:Child; D002673:Child, Hospitalized; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D025202:Molecular Diagnostic Techniques; D009055:Mouth / Q000821:virology*; D009296:Nasal Cavity / Q000821:virology*; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods*; D014777:Virus Diseases / Q000175:diagnosis* / Q000821:virology*; D014780:Viruses / Q000302:isolation & purification*
children, hospitalized; human metapneumovirus; influenza, human; parainfluenza; respiratory syncytial virus infections