Thermomechanical effects caused by heavy ions propagating in tissue.
The thermomechanical effects caused by ions propagating in tissue are discussed. Large energy densities in small regions surrounding ion paths cause shock waves propagating in tissue. The strength of the shock waves depends on the linear energy transfer. Molecular dynamics simulations help in determining the necessary strength of shock waves in order for the stresses caused by them to directly produce DNA strand breaks. At much smaller values of linear energy transfer, the shock waves may be instrumental in propagating reactive species formed close to the ion's path to large distances, successfully competing with diffusion.
MBN Research Center, Frankfurt am Main 60438, Germany solovyov@mbnresearch.com.
Andrey V
AV
Solov'yov
Physics Department, Oakland University, Rochester, MI 48309, USA.
Eugene
E
Surdutovich
D004249:DNA Damage / Q000528:radiation effects*; D004058:Diffusion; D020450:Heavy Ions / Q000009:adverse effects*; D019220:High-Energy Shock Waves / Q000009:adverse effects*; D018499:Linear Energy Transfer / Q000528:radiation effects*; D056004:Molecular Dynamics Simulation; D013314:Stress, Mechanical; D013696:Temperature