Enantioselective N-heterocyclic carbene-catalyzed synthesis of trifluoromethyldihydropyridinones.
The enantioselective N-heterocyclic carbene-catalyzed [4 + 2] cyclocondensation of α-chloroaldehydes and trifluoromethyl N-Boc azadienes was developed, giving the corresponding 3,4-disubstituted-6-trifluoromethyldihydropyridin-2(1H)-ones in good yields with exclusive cis-selectivities and excellent enantioselectivities.
†Marine College, Shandong University at Weihai, 180 Wenhua West Road, Weihai 264209, China.|‡Beijing National Laboratory for Molecular Science, Key Laboratory of Molecular Recognition and Functional, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Dong-Ling
DL
Wang
‡Beijing National Laboratory for Molecular Science, Key Laboratory of Molecular Recognition and Functional, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Zhi-Qin
ZQ
Liang
†Marine College, Shandong University at Weihai, 180 Wenhua West Road, Weihai 264209, China.|‡Beijing National Laboratory for Molecular Science, Key Laboratory of Molecular Recognition and Functional, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Kun-Quan
KQ
Chen
†Marine College, Shandong University at Weihai, 180 Wenhua West Road, Weihai 264209, China.
De-Qun
DQ
Sun
‡Beijing National Laboratory for Molecular Science, Key Laboratory of Molecular Recognition and Functional, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Song
S
Ye