[Expression of CXC chemokine ligand 16 and chemokine receptor 6 in periodontal tissues of patients with moderately severe periodontitis].
OBJECTIVE
To investigate the expression and localization of CXCLl6 and its receptor CXCR6 in gingival tissues of patients with chronic periodontitis and analyze the roles in the occurrence and development of periodontitis.


METHODS
Gingival tissues with moderately severe periodontitis were collected from 39 patients treated in People's Hospital of Liaoning Province. Forty persons with healthy gingiva were used as control. The age of the enrolled subjects ranged from 35 to 74 years old. Immunohistochemical technique was applied to detect the expression and localization of CXCLl6 and CXCR6 protein gingival tissues of all subjects. The data was analyzed with SPSS 15.0 software package.


RESULTS
Compared with normal group, the expression of CXCLl6 and CXCR6 were significantly up-regulated in patients with periodontitis (P<0.05). There was a positive relationship between the protein expression of CXCLl6 and CXCR6 in gingival tissues of patients with periodontitis (r=0.580, P<0.05).


CONCLUSIONS
CXCLl6 and CXCR6 may be involved in the development of chronic periodontitis. The expression of CXCLl6 and CXCR6 may work coordinately to promote the development of chronic periodontitis.
Department of Stomatology, People's Hospital of Liaoning Province. Shenyang 110016, Liaoning Province, China.E-mail:xiaojusun@sina.com.
Xiao-ju
XJ
Sun
Jun-chi
JC
Hou
Hong
H
Xie
Hui
H
Zhang
Wei
W
Deng
Yun
Y
Wang
D019743:Chemokines, CXC; D055113:Chronic Periodontitis; D005881:Gingiva; D006801:Humans; D010518:Periodontitis; D019707:Receptors, Chemokine
D019743:Chemokines, CXC; D019707:Receptors, Chemokine