The clinical response and systemic effects of non-surgical periodontal therapy in end-stage renal disease patients: a 6-month randomized controlled clinical trial.
OBJECTIVE
Scientific evidence on the effects of chronic periodontitis on end-stage renal disease (ESRD) remains inadequate and inconclusive. This intervention study was designed to evaluate the effects of non-surgical periodontal therapy on the clinical response and systemic status of ESRD patients.


METHODS
Patients in the intervention group (n = 48) received non-surgical periodontal therapy and then a supragingival prophylaxis at the 3-month follow up, and those in the control group (n = 49) received no intervention throughout the study. At 6 weeks, 3 months, and 6 months after therapy, clinical periodontal examinations were conducted and blood samples were taken to evaluate inflammatory, nutritional and lipid profiles.


RESULTS
The results showed a significant improvement in clinical periodontal parameters (p < 0.05) in the intervention group. Compared to the control group, the intervention group had significantly lower high-sensitivity C-reactive protein at 3 months and 6 months. Significant improvements were found (p < 0.05) in interleukin-6, ferritin, albumin, creatinine, blood urea nitrogen, and transferrin after therapy.


CONCLUSIONS
Non-surgical periodontal therapy can effectively improve periodontal, circulating inflammatory and nutritional status in ESRD patients. Non-surgical periodontal therapy, as a relatively simple intervention, has beneficial systemic effects in ESRD patients.
College of Stomatology, Southern Medical University, Guangzhou, China.|Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fuchun
F
Fang
College of Stomatology, Southern Medical University, Guangzhou, China.|Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Buling
B
Wu
College of Stomatology, Southern Medical University, Guangzhou, China.
Qian
Q
Qu
College of Stomatology, Southern Medical University, Guangzhou, China.|Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jie
J
Gao
College of Stomatology, Southern Medical University, Guangzhou, China.|Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Wenjuan
W
Yan
College of Stomatology, Southern Medical University, Guangzhou, China.|Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xin
X
Huang
College of Stomatology, Southern Medical University, Guangzhou, China.|Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Dandan
D
Ma
College of Stomatology, Southern Medical University, Guangzhou, China.
Jin
J
Yue
College of Stomatology, Southern Medical University, Guangzhou, China.
Ting
T
Chen
College of Stomatology, Southern Medical University, Guangzhou, China.
Fei
F
Liu
College of Stomatology, Southern Medical University, Guangzhou, China.
Ying
Y
Liu
D001806:Blood Urea Nitrogen; D002097:C-Reactive Protein / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D055113:Chronic Periodontitis / Q000097:blood / Q000150:complications / Q000628:therapy*; D003404:Creatinine / Q000097:blood; D003774:Dental Plaque Index; D003777:Dental Prophylaxis / Q000379:methods; D005260:Female; D005293:Ferritins / Q000097:blood; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000628:therapy; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000628:therapy; D057747:Periodontal Debridement / Q000379:methods*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000628:therapy; D012709:Serum Albumin / Q000032:analysis; D014168:Transferrin / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C508600:IL6 protein, human; D015850:Interleukin-6; D012709:Serum Albumin; D014168:Transferrin; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D005293:Ferritins; D003404:Creatinine
end-stage renal disease; haemodialysis; non-surgical periodontal therapy; periodontitis