Soluble B7-H2 as a novel marker in early evaluation of the severity of acute pancreatitis.
The clinical usefulness of soluble B7-H2 (sB7-H2) as an early indicator of acute pancreatitis (AP) remains unclear, so we performed the present study to investigate this issue. For our cohort, we recruited 75 patients with AP, 70 patients with other abdominal sepsis, and 20 healthy control individuals. The sB7-H2 levels of AP patients or healthy control individuals were measured by enzyme-linked immunosorbent assay (ELISA). The sB7-H2 levels in patients with AP rather than other patients with abdominal sepsis were significantly higher than those in healthy controls. Hence, we selected AP to study the clinical significance of sB7-H2 in inflammatory conditions. The sB7-H2 level was positively correlated with the white blood cell (WBC) count and the lactate dehydrogenase (LDH), high-sensitivity C-reactive protein (hs-CRP), and lipopolysaccharide LPS levels (P <.05 for each). Receiver operating characteristic (ROC) analysis revealed that sB7-H2 can distinguish moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP) from mildly acute pancreatitis (MAP) with 77.8% sensitivity and 80.0% specificity; and that the levels of sB7-H2 also can distinguish SAP from MSAP and MAP with 92.0% sensitivity and 86.0% specificity. The present results indicate that sB7-H2 might be a useful marker in the clinical diagnosis of AP.
Department of Emergency Internal Medicine of the First Affiliated Hospital, Suzhou University, China huangjian1997@163.com.
Jian
J
Huang
Department of General Surgery, No. 7 Hospital of Changzhou People's Hospital, China.
Zhengwang
Z
Wu
Department of Emergency Internal Medicine of the First Affiliated Hospital, Suzhou University, China.
Shiqi
S
Lu
Department of Emergency Internal Medicine of the First Affiliated Hospital, Suzhou University, China.
Jiaqing
J
Shen
Department of Emergency Internal Medicine of the First Affiliated Hospital, Suzhou University, China.
Xiaoming
X
Kong
School of Public Health at the Medical College of Suzhou University, China.
Yueping
Y
Shen
D000208:Acute Disease; D000328:Adult; D000704:Analysis of Variance; D060887:B7 Antigens / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000175:diagnosis*; D012372:ROC Curve; D012698:Serologic Tests; D012720:Severity of Illness Index
D060887:B7 Antigens; D008070:Lipopolysaccharides; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase
Serological detection; acute pancreatitis; diagnosis; sB7-H2