Cyclodextrin-promoted energy transfer for broadly applicable small-molecule detection.
Reported herein is the development of non-covalent, proximity-induced energy transfer from small-molecule toxicants to organic fluorophores bound in the cavity of γ-cyclodextrin. This energy transfer occurs with exceptional efficiency for a broad range of toxicants in complex biological media, and is largely independent of the spectral overlap between the donor and acceptor. This generally applicable phenomenon has significant potential in the development of new turn-on detection schemes.
Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, RI 02881, USA.
Nicole
N
Serio
Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, RI 02881, USA.
Chitapom
C
Chanthalyma
Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, RI 02881, USA.
Lindsey
L
Prignano
Department of Chemistry, University of Rhode Island, 51 Lower College Road, Kingston, RI 02881, USA.
Mindy
M
Levine
cyclodextrin; energy transfer; fluorescence spectroscopy