Oxidative/Antioxidative status in obese and sport trained children: a comparative study.
The aim of the study was to compare oxidative/antioxidative status in obese and sport trained children and to correlate obtained redox markers with anthropometrical measurements, body composition parameters, and adipokines levels. 78 (44 males) obese (SG) and 80 (40 males) normal weight sport trained (CG) children matched for age and Tanner stage were recruited for the study. Body composition parameters and basal metabolic rate (BMR) were assessed by bioelectrical impedance analysis (BIA). Oxidative/antioxidative status was evaluated in plasma by total oxidative status (PerOX), oxidized-LDL cholesterol (oxLDL), total antioxidative capacity (ImAnOx), and glutathione peroxidase activity (GPx). Leptin and adiponectin levels and adiponectin/leptin ratio (A/L) were also investigated. OxLDL was higher in SG versus CG (P < 0.05), but ImAnOx and GPx were reduced in SG versus CG (P < 0.01). Redox markers correlated significantly with BMI Z-score, WHR, WHtR, body composition parameters, leptin (in boys only), and A/L ratio (in boys only) in SG and in a whole studied population. PerOX significantly correlated with BMR in the CG. Antioxidative/oxidative status in obese children is significantly impaired and related adipose tissue excess and its hormonal activity. Oxidative status assessed by PerOx is also high in sport trained children but antioxidative defense is significantly more efficient with no overproduction of oxidized LDL.
School of Medicine in Katowice, Department of Pediatrics, Pediatric Endocrinology and Diabetes, Medical University of Silesia, Medykow 16, 40-752 Katowice, Poland.
Pawel
0000-0002-8943-7051
P
Matusik
School of Medicine in Katowice, Department of Pediatrics, Pediatric Endocrinology and Diabetes, Medical University of Silesia, Medykow 16, 40-752 Katowice, Poland.
Zofia
0000-0002-0965-2107
Z
Prokopowicz
School of Medicine in Katowice, Department of Pediatrics, Pediatric Endocrinology and Diabetes, Medical University of Silesia, Medykow 16, 40-752 Katowice, Poland.
Berenika
B
Norek
School of Medicine in Katowice, Health Promotion and Obesity Management Unit, Department of Pathophysiology, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.
Magdalena
M
Olszanecka-Glinianowicz
School of Medicine in Katowice, Pathophysiology Unit, Department of Pathophysiology, Medical University of Silesia, Medykow 18, 40-752 Katowice, Poland.
Jerzy
J
Chudek
School of Medicine in Katowice, Department of Pediatrics, Pediatric Endocrinology and Diabetes, Medical University of Silesia, Medykow 16, 40-752 Katowice, Poland.
Ewa
E
Malecka-Tendera
D054392:Adipokines / Q000097:blood*; D000273:Adipose Tissue / Q000378:metabolism / Q000503:physiopathology*; D000293:Adolescent; D000886:Anthropometry; D001823:Body Composition; D015992:Body Mass Index; D002648:Child; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D018384:Oxidative Stress
D054392:Adipokines