The regulation of radiosensitivity by p53 and its acetylation.
The p53 signaling pathway plays critical roles in determining the radio-sensitivity of normal tissues but is frequently inactivated in cancer. In various cancer cells, p53 has different effects on radio-sensitivity through complex mechanisms. Acetylation of p53 is an important means of post-translational modifications and is indispensable for its activation that is a reversible enzymatic process. Both acetylation and deacetylation of p53 are involved in the fine regulation of cellular responses to DNA damage and genotoxic stress, such as radiation. Targeting the acetylation of p53 may enable the modulation of radio-sensitivity of cancer cells.
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.
Jing
J
Zhang
Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: lfshen2008@163.com.
Liangfang
L
Shen
Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: lunquansun@csu.edu.cn.
Lun-Quan
LQ
Sun
D000107:Acetylation; D004249:DNA Damage / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy*; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D011836:Radiation Tolerance / Q000235:genetics*; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D054875:Ubiquitination / Q000235:genetics
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53
Acetylation; P53; Posttranslational modifications; Radio sensitivity; Radiotherapy