A new phenolic glycoside from Spiraea prunifolia var. simpliciflora twigs.
The phytochemical investigation of the methanol extract from the twigs of Spiraea prunifolia var. simpliciflora (Rosaceae) using column chromatography led to the isolation of a new phenol glycoside, 1-O-(E)-caffeoyl-2-O-p-(E)-coumaroyl-β-D-glucopyranose (1), together with 16 known phenolic compounds (2-17). The structure of this new compound was elucidated by analysis of spectroscopic data including 1D, 2D nuclear magnetic resonance and HR-FAB-MS data. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using the sulforhodamine B bioassay.
Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.
Sung Wan
SW
Jang
Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.
Won Se
WS
Suh
Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.
Chung Sub
CS
Kim
Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.
Ki Hyun
KH
Kim
Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea. krlee@skku.edu.
Kang Ro
KR
Lee
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D031992:Spiraea / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010636:Phenols; D000432:Methanol
Cytotoxicity; Phenolic glycoside; Spiraea prunifolia var. simpliciflora