Constant infusion transpulmonary thermodilution for the assessment of cardiac output in exercising humans.
To determine the accuracy and precision of constant infusion transpulmonary thermodilution cardiac output (CITT-Q) assessment during exercise in humans, using indocyanine green (ICG) dilution and bolus transpulmonary thermodilution (BTD) as reference methods, cardiac output (Q) was determined at rest and during incremental one- and two-legged pedaling on a cycle ergometer, and combined arm cranking with leg pedaling to exhaustion in 15 healthy men. Continuous infusions of iced saline in the femoral vein (n = 41) or simultaneously in the femoral and axillary (n = 66) veins with determination of temperature in the femoral artery were used for CITT-Q assessment. CITT-Q was linearly related to ICG-Q (r = 0.82, CITT-Q = 0.876 × ICG-Q + 3.638, P < 0.001; limits of agreement ranging from -1.43 to 3.07 L/min) and BTD-Q (r = 0.91, CITT-Q = 0.822 × BTD + 4.481 L/min, P < 0.001; limits of agreement ranging from -1.01 to 2.63 L/min). Compared with ICG-Q and BTD-Q, CITT-Q overestimated cardiac output by 1.6 L/min (≈ 10% of the mean ICG and BTD-Q values, P < 0.05). For Q between 20 and 28 L/min, we estimated an overestimation < 5%. The coefficient of variation of 23 repeated CITT-Q measurements was 6.0% (CI: 6.1-11.1%). In conclusion, cardiac output can be precisely and accurately determined with constant infusion transpulmonary thermodilution in exercising humans.
Department of Physical Education, Research Institute of Biomedical and Health Sciences, IUIBS, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
J A L
JA
Calbet
Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.|The Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.|Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
S P
SP
Mortensen
Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.|The Centre of Inflammation and Metabolism, Centre for Physical Activity Research, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
G D W
GD
Munch
Department of Physical Education, Research Institute of Biomedical and Health Sciences, IUIBS, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.|Emergency Medicine Department, Insular Universitary Hospital of Gran Canaria, Las Palmas de Gran Canaria, Spain.
D
D
Curtelin
Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.|Åstrand Laboratory, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.
R
R
Boushel
D000328:Adult; D000368:Aged; D001367:Axillary Vein; D002302:Cardiac Output; D003080:Cold Temperature; D004396:Coloring Agents; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005263:Femoral Artery; D005268:Femoral Vein; D006801:Humans; D007208:Indocyanine Green; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012146:Rest / Q000502:physiology; D012965:Sodium Chloride / Q000008:administration & dosage; D013815:Thermodilution / Q000379:methods*; D055815:Young Adult
D004396:Coloring Agents; D012965:Sodium Chloride; D007208:Indocyanine Green
Cardiac output; arm exercise; blood flow; exercise; humans; performance; thermistor; thermodilution