Oxygen and viruses: a breathing story.
The effect of oxygen on virus replication is complex, and the role of hypoxia-inducible factor 1α (HIF-1α) in the metabolism of virus-infected cells remains uncertain. Solid tumours are hypoxic, and some viruses use this low oxygen tension level to facilitate their replication in tumour cells, thereby causing cell lysis. In addition, the interactions between viruses and HIF-1α may stimulate a trained immunity. However, the evolutionary basis for the oxygen regulatory mechanism of virus replication is ill-defined and requires further investigation.
Hôpital Saint Louis - Université Paris, Diderot-Paris 7, Paris, France.
Frédéric
F
Morinet
Hôpital Ambroise Paré-Université de Versailles, Saint Quentin en Yvelynes, Versailles, France.
Mathilde
M
Parent
Laboratoire de Fractionnement et des Biotechnologies, Les Ulis, Paris, France.
Corinne
C
Bergeron
Laboratoire des Agents Infectieux et Hygiène - Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France.
Sylvie
S
Pillet
Hôpital Ambroise Paré-Université de Versailles, Saint Quentin en Yvelynes, Versailles, France.
Claude
C
Capron
D000818:Animals; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D014777:Virus Diseases / Q000235:genetics / Q000378:metabolism* / Q000821:virology*; D018406:Virus Physiological Phenomena; D014779:Virus Replication; D014780:Viruses / Q000235:genetics
D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D010100:Oxygen