A highly selective phenothiazine-based fluorescence 'turn-on' indicator based on cyanide-promoted novel protection/deprotection mechanism.
A cyanide anion (CN(-))-triggered deprotection of NH-protected phenothiazine, (E)-10-(10H-phenothiazin-3'-yl)propenal, has been discovered as a novel mechanism for the highly selective fluorescence detection of CN(-) under ambient conditions. The present protocol may pave the way for its broad application in organic synthesis in the near future.
Department of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan. ycling@mx.nthu.edu.tw bhaskargarg111@gmail.com.
Bhaskar
B
Garg
Yong-Chien
YC
Ling
D000171:Acrolein / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D003486:Cyanides / Q000032:analysis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010640:Phenothiazines / Q000138:chemical synthesis / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
C000604906:10-(10H-phenothiazin-3'-yl)propenal; D003486:Cyanides; D005456:Fluorescent Dyes; D010640:Phenothiazines; D000171:Acrolein