Topical delivery of dexamethasone acetate from hydrogel containing nanostructured liquid carriers and the drug.
The potential of hydrogel containing nanostructured lipid carriers (NLC) to enhance the skin permeation rate and skin deposition of dexamethasone acetate (DEA) was investigated. The particle size of obtained NLCs was around 224.4 nm. NLCs had core-shell structure and DEA existed in amorphous state in NLCs. The permeation rate of DEA through excised mouse skins from hydrogel containing DEA-NLC (DEA-NLC-hydrogel) was 7.3 times higher than DEA-ointment. The skin deposition of DEA from DEA-NLC-hydrogel increased 3.8 folds compared to that from solution of DEA in hydrogel (DEA-hydrogel).
Department of Pharmaceutics, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoankiem, Hanoi, Vietnam. thachtungdhd@gmail.com.
Nguyen-Thach
NT
Tung
Department of Pharmaceutics, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoankiem, Hanoi, Vietnam.
Vu-Thu
VT
Huyen
College of Pharmacy, Gachon University, Hambakmoeiro 191, Yeonsu-gu, Incheon, 406-799, Korea. scchi@gachon.ac.kr.
Sang-Cheol
SC
Chi
D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D003907:Dexamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D020100:Hydrogels; D008055:Lipids / Q000737:chemistry*; D008297:Male; D051379:Mice; D049329:Nanostructures; D010316:Particle Size; D010539:Permeability; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption
D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D020100:Hydrogels; D008055:Lipids; D003907:Dexamethasone; C018038:dexamethasone acetate
Dexamethasone acetate; Hydrogel; Nanostructured lipid carrier; Permeation rate; Skin deposition