Daily profiles of dehydroepiandrosterone and its hydroxylated metabolites with respect to food intake.
Eight women of reproductive age with normal body mass index were given 5 standardised meals, and their hormonal milieu was determined during the course of the day. Plasma from 12 withdrawals was analysed for dehydroepiandrosterone and its 7- and 16-hydroxylated metabolites. Overall, there was a maximum in the levels of steroid hormones in the morning, followed by decreases throughout the day. There was also an additional significant decrease found for dehydroepiandrosterone and its 7α-hydroxyderivative in association with the consumption of main meals, but not for the 7β-isomer or 16α-hydroxyderivative.
Institute of Endocrinology, Prague, Czech Republic. lstarka@endo.cz.
Luboslav
L
Stárka
Institute of Endocrinology, Prague, Czech Republic.
Beata
B
Rácz
Institute of Endocrinology, Prague, Czech Republic.
Monika
M
Šrámková
Institute of Endocrinology, Prague, Czech Republic.
Martin
M
Hill
Institute of Endocrinology, Prague, Czech Republic.
Michaela
M
Dušková
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000493:pharmacokinetics; D000328:Adult; D003687:Dehydroepiandrosterone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004435:Eating / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006900:Hydroxylation
D000276:Adjuvants, Immunologic; D003687:Dehydroepiandrosterone