Polymorphisms of interleukin-10 genes on the risk of ischemic stroke in a meta-analysis.
BACKGROUND
Previous studies have investigated the associations between polymorphisms of interleukin-10 (IL-10) gene and risk of ischemic stroke (IS). However, the results were inconsistent. The aim of this study was to clarify the relationship between IL-10 polymorphisms and IS risk by a meta-analysis approach.


METHODS
The meta-analysis was performed by searching PubMed and Wanfang databases. Odds ratio (OR) and corresponding 95% confidence interval (95% CI) as well as effect size were calculated by a fixed or random-effect model according to the I(2) value. In total, five case-control studies for IL10-1082G/A and four studies for IL10-819C/T were included in this meta-analysis.


RESULTS
Combined analysis indicated that IL10-1082G/A polymorphism was associated with risk of IS (A/A vs. G/G+G/A: OR = 1.82, 95% CI = 1.21-2.74, P = 0.004; for A allele vs. G allele: OR = 1.55, 95% CI = 1.14-2.10, P = 0.006). However, there was no significant association between IL10-819C/T polymorphism and IS in any comparison model (C/C vs. T/C+T/T: OR = 0.96, 95% CI = 0.69-1.36, P = 0.84; C allele vs. T allele: OR = 1.00, 95% CI = 0.83-1.21, P = 0.97).


CONCLUSIONS
Our results indicated that IL-10-1082G/A polymorphism, but not IL10-819C/T polymorphism was associated with the risk of IS.
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Guo-Ting
GT
Yin
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Yi-Tong
YT
Ma
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Ying-Ying
YY
Zheng
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Yi-Ning
YN
Yang
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Xiao-Mei
XM
Li
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Zhen-Yan
ZY
Fu
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Jing-Zhan
JZ
Zhang
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Chuan-Fang
CF
Dai
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Fen
F
Liu
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Bang-Dang
BD
Chen
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Min-Tao
MT
Gai
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830054, P.R. China.
Xiang
X
Xie
Interleukin-10 genes; ischemic stroke; meta-analysis; polymorphisms