Ribbon synapses in zebrafish hair cells.
The basic architecture and functionality of ribbon synapses of mechanosensitive hair cells are well conserved among vertebrates. Forward and reverse genetic methods in zebrafish (Danio rerio) have identified components that are critical for the development and function of ribbon synapses. This review will focus on the findings of these genetic approaches, and discuss some emergent concepts on the role of the ribbon body and calcium in synapse development, and how perturbations in synaptic vesicles lead to a loss of temporal fidelity at ribbon synapses. This article is part of a Special Issue entitled <Auditory Synaptology>.
Oregon Hearing Research Center and Vollum Institute, 3181 SW Sam Jackson Park Road, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: nicolson@ohsu.edu.
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D000818:Animals; D030801:Animals, Genetically Modified; D001306:Auditory Pathways / Q000502:physiology; D020013:Calcium Signaling; D005838:Genotype; D006198:Hair Cells, Auditory / Q000378:metabolism / Q000502:physiology*; D006309:Hearing; D040542:Mechanotransduction, Cellular; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D009435:Synaptic Transmission; D015027:Zebrafish / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism
D009419:Nerve Tissue Proteins; D029961:Zebrafish Proteins