Mitochondria, muscle health, and exercise with advancing age.
Skeletal muscle health is dependent on the optimal function of its mitochondria. With advancing age, decrements in numerous mitochondrial variables are evident in muscle. Part of this decline is due to reduced physical activity, whereas the remainder appears to be attributed to age-related alterations in mitochondrial synthesis and degradation. Exercise is an important strategy to stimulate mitochondrial adaptations in older individuals to foster improvements in muscle function and quality of life.
Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
Heather N
HN
Carter
Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
Chris C W
CC
Chen
Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada dhood@yorku.ca.
David A
DA
Hood
D000367:Age Factors; D000375:Aging / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics; D015444:Exercise; D020022:Genetic Predisposition to Disease; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism* / Q000473:pathology; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009154:Mutation; D012307:Risk Factors; D055948:Sarcopenia / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*
D004272:DNA, Mitochondrial