S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.
A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S-nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, is dependent on nitric oxide release through transnitrosation as S-nitrosocysteine, a potent endogenous nitric oxide donor.
School of Materials Science and Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.|Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.
Alex
A
Schudel
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.|School of Electrical and Computer Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.
Timothy
T
Kassis
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.|George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.|Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.
J Brandon
JB
Dixon
Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.|George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.|Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 315 Ferst Dr NW, Atlanta, GA, 30332, USA.|Winship Cancer Institute, Emory University, 1365 Clifton Road, Atlanta, GA, 30322, USA.
Susan N
SN
Thomas
D000328:Adult; D000818:Animals; D017178:Brugia malayi / Q000187:drug effects / Q000502:physiology; D003545:Cysteine / Q000031:analogs & derivatives / Q000737:chemistry; D005260:Female; D006801:Humans; D009043:Motor Activity / Q000187:drug effects; D053758:Nanoparticles / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry / Q000633:toxicity; D011126:Polypropylenes / Q000737:chemistry*; D026403:S-Nitrosothiols / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry
D011126:Polypropylenes; D026403:S-Nitrosothiols; D013438:Sulfhydryl Compounds; D013440:Sulfides; D009569:Nitric Oxide; C021315:S-nitrosocysteine; D003545:Cysteine
B. malayi; NO donors; nanoparticles; nitric oxide; nitrosothiol