Interleukin-1β rs1143634 polymorphism and aggressive periodontitis susceptibility: a meta-analysis.
Multiple studies had focused on the association between interleukin-1 (IL-1) rs1143634 polymorphism and aggressive periodontitis (AgP) susceptibility, but the results remained inconclusive. Therefore, this meta-analysis was conducted to explore its role in the development of AgP. PubMed and Embase databases were searched up to April 15, 2014. After study selection and data extraction form eligible studies, meta-analysis was performed. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association. All the analysis was performed using Comprehensive Meta-Analysis software. Finally a total of 25 case-control studies were included. The pooled results showed non-association between AgP susceptibility and IL-1 rs1143634 polymorphism [for T vs. C: OR = 0.99, 95% CI = 0.79-1.23; for TT vs. CC: OR = 1.14, 95% CI = 0.78-1.66; for CT vs. CC: OR = 0.97, 95% CI = 0.70-1.36; for (CT + TT) vs. CC: OR = 1.02, 95% CI = 0.76-1.37; for TT vs. (CT + CC): OR = 1.22, 95% CI = 0.85-1.75]. Subgroup analyses remain did not find any association. No publication bias was detected. Hence, our meta-analysis showed that IL-1β rs1143634 polymorphism is not linked to AgP susceptibility, regardless of ethnicity.
Department of Stomatology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, PR China.
Yong-Ji
YJ
Chen
Administrative Office, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
Ying
Y
Han
Department of Stomatology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, PR China.
Min
M
Mao
Department of Stomatology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, PR China.
Ya-Qin
YQ
Tan
Department of Stomatology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, PR China.
Wei-Dong
WD
Leng
Department of Stomatology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, PR China ; Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China ; Center for Evidence-Based and Translational Medicine, Zhongnan Hospital, Wuhan University Wuhan 430071, PR China ; Center for Evidence-Based and Translational Medicine, Wuhan University Wuhan 430071, PR China.
Xian-Tao
XT
Zeng
Interleukin-1; aggressive periodontitis; meta-analysis; periodontitis; polymorphism