Evaluation of adipocytokines in children with chronic kidney disease.
BACKGROUND
Adipose tissue through the many secreted adipocytokines creates a highly active metabolic and endocrine organ. The evaluation of serum adipocytokine concentration in children with chronic kidney disease (CKD) could serve as a marker of cardio-vascular complication progression and an index of outcome in adulthood and after kidney transplantation.


METHODS
The aim of the study was to evaluate simultaneously the serum concentrations of six different adipocytokines: adiponectin, apelin, chemerin, omentin, resistin, and vaspin, in 28 children with CKD stage 5 on haemodialysis and peritoneal dialysis.


RESULTS
The concentration of apelin, omentin, and resistin in children with CKD was significantly higher and the concentration of vaspin, adiponectin, and chemerin was significantly lower than in the control group. After adjusting to body mass index (BMI), the same results were obtained. After adjusting to body surface area (BSA), the concentration of vaspin, adiponectin, and chemerin did not differ between children with CKD and the control group. In analysis of the correlation between serum total adipocytokine levels in children with CKD we found a negative relationship in pairs: omentin-apelin and omentin-vaspin, and positive in pairs: adiponectin-chemerin and adiponectin-resistin.


CONCLUSIONS
Our results show that changes in serum adipocytokines concentration are associated with the kidney dysfunction in CKD in children. Longitudinal studies on larger groups of paediatric cohorts would be helpful in investigating whether adipocytokines play a harmful role in the development of CKD and would enable further understanding of the risk factors for CKD progression.
Chair and Department of Paediatrics, Zabrze, Medical University of Silesia, School of Medicine with the Division of Dentistry, Poland. dializy_dzieciece_zabrze@poczta.onet.pl.
Maria
M
Szczepańska
Edyta
E
Machura
Piotr
P
Adamczyk
Elżbieta
E
Świętochowska
Elżbieta
E
Trembecka-Dubel
Katarzyna
K
Lipiec
Agnieszka
A
Jędzura
Katarzyna
K
Ziora
D054392:Adipokines / Q000097:blood* / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood*
D054392:Adipokines; D015415:Biomarkers