Could a trace mineral deficiency be associated with congenital chondrodystrophy of unknown origin (CCUO) in beef cattle in Australia?
Congenital chondrodystrophy of unknown origin (CCUO) has been reported in beef cattle worldwide. A trace mineral deficiency in pregnant dams has been suggested as causing the deformities seen in CCUO calves. An extended outbreak of CCUO in Australia between 2002 and 2009 provided an opportunity to examine the pattern of trace mineral status in gestating cows and the effect of parenteral trace mineral supplementation on a herd at risk of CCUO calves. A property with a strong history of CCUO was identified from a previous case-control study. A randomly selected sample of multiparous (8 to 10 years old) Angus and Angus cross cows (n = 20) was assigned to control (no injection) or supplement group given three injections at the recommended dose rate of chelated mineral supplement (Mn, Zn, Cu and Se) at 6-week intervals in mid- to late gestation. Liver biopsies were performed to measure liver Mn, Zn, Cu and Fe at each injection time and 1 month post-calving. Pasture samples were also collected for analysis. Supplemented cows had higher liver Cu levels compared to control cows (p < 0.001), but there was no difference between supplement and control cows for liver Zn, Fe or Mn. Liver Cu (p < 0.001), Fe (p < 0.001) and Zn (p < 0.001) fell during gestation and liver Mn increased after calving (p < 0.001). Three cows from the control group and two from the supplement group had liver zinc levels below the normal values at the end of the trial. Two cows from the control group and one from the treatment group gave birth to cows with signs of CCUO including superior brachygnathia. All cows except one from the control group had rough dry coats with excessive dander. The role of trace mineral status in the birth of CCUO calves, especially the role of zinc deficiency, requires further investigation.
Faculty of Veterinary Science, University of Sydney, Camperdown, NSW, Australia.
P J
PJ
White
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001315:Australia / Q000453:epidemiology; D002417:Cattle; D002418:Cattle Diseases / Q000151:congenital* / Q000453:epidemiology / Q000209:etiology; D019587:Dietary Supplements; D005260:Female; D008099:Liver; D010009:Osteochondrodysplasias / Q000151:congenital / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D011247:Pregnancy; D014131:Trace Elements / Q000172:deficiency*
D014131:Trace Elements
birth defect; deficiency; manganese; zinc