Changes of Plasma Tumor Necrosis Factor α and C-Reactive Protein Levels in Patients with Hypertension Accompanied by Impaired Glucose Tolerance and their Clinical Significance.
BACKGROUND
Chronic inflammation could affect the occurrence and development of malignant tumors. To explore the levels of tumor necrosis factor α (TNF-α) and C-reactive protein (CRP) in patients accompanied by impaired glucose tolerance (IGT) and their clinical significance.


METHODS
A total of 210 patients hospitalized in Affiliated Hospital of Taishan Medical University from Jun., 2013 to Dec., 2014 were selected, in which 92 cases were accompanied by IGT. Meanwhile, 80 randomly-selected healthy people by physical examination were as the control. The levels of routine biochemical indexes, plasma TNF-α and CRP in all subjects were measured.


RESULTS
Both systolic and diastolic pressures in hypertension group and hypertension plus IGT group were significantly higher than in control group (p<0.01), but there was no statistical significance between these two groups (p>0.05). The levels of fasting plasma glucose (FPG) and blood glucose 2 h after taking glucose in hypertension plus IGT group were markedly higher than other groups (p<0.01). Homeostasis model assessment-insulin resistance (HOMA-IR), TNF-α and CRP contents were on the progressive increase in control, hypertension and hypertension plus IGT groups, but significant differences were presented among each group (P<0.01). Hypertension accompanied by IGT had a significantly-positive association with CRP, TNF-α, FPG and blood glucose 2h after taking glucose.


CONCLUSIONS
The levels of plasma TNF-α and CPR in patients with hypertension accompanied by IGT increase significantly, indicating that inflammatory reaction in these patient increases, thus suggesting that these patients should be focused regarding cancer prevention.
Department of Cardiovascular Medicine, Affiliated Hospital of Taishan Medical University, Taian, China E-mail : Kathy0418@163.com.
Qiang
Q
Xiao
Lan-Ping
LP
Wang
Zhang-Shen
ZS
Ran
Xin-Huan
XH
Zhang
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D002097:C-Reactive Protein / Q000276:immunology* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D018149:Glucose Intolerance / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D007249:Inflammation; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000378:metabolism
D001786:Blood Glucose; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein