Sandensone A, a novel sesquiterpenoid from the Formosan soft coral Sinularia sandensis.
A chromatographic and NMR spectroscopy-based fractionation on the acetone extracts of the soft coral Sinularia sandensis led to the isolation of a novel sesquiterpenoid, sandensone A (1). The structure of 1 was elucidated based on comprehensive 1D and 2D NMR spectroscopic data as well as HRESIMS spectrometry. The absolute configuration at C-12 of 1 was determined as R using a modified Mosher's method. The cytotoxicity against A549 (human lung carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cancer cell lines as well as antiviral activity against HCMV (human cytomegalovirus) were evaluated in vitro.
Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
Shi-Yie
SY
Cheng
Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Shang-Kwei
SK
Wang
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Pei-Wen
PW
Chen
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: yihduh@mail.nsysu.edu.tw.
Chang-Yih
CY
Duh
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D003587:Cytomegalovirus; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D012717:Sesquiterpenes / Q000737:chemistry*
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D012717:Sesquiterpenes; C000604943:sandensone A
Antiviral activity; Cytotoxicity; HCMV (human cytomegalovirus); Sesquiterpenoid; Sinularia sandensis