Infection, systemic inflammation, and Alzheimer's disease.
Alzheimer's disease (AD) is a leading cause of dementia among elderly. Yet, its etiology remains largely unclear. In this review, we summarize studies that associate systemic infection and neuroinflammation with AD, while highlighting that early-life or life-long exposure to infectious agents predisposes one to develop AD at a later age.
Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Siok Lam
SL
Lim
Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA.
Carlos J
CJ
Rodriguez-Ortiz
Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, CA 95343, USA. Electronic address: mkitazawa@ucmerced.edu.
Masashi
M
Kitazawa
D000544:Alzheimer Disease / Q000150:complications / Q000209:etiology*; D006801:Humans; D007239:Infections / Q000150:complications / Q000473:pathology; D007249:Inflammation / Q000150:complications / Q000473:pathology; D012307:Risk Factors
Alzheimer's disease; Environment; Infection; Inflammation; Risk factors; Sporadic