UK guidance for the pathological reporting of serrated lesions of the colorectum.
Bowel cancer screening programmes have highlighted to endoscopists and clinicians the spectrum of serrated colorectal lesions. One of the most significant developments has been the recognition that sessile serrated lesions (SSLs), while bearing histological resemblance to hyperplastic polyps (HPs), may be associated with the enhanced development of epithelial dysplasia and colorectal adenocarcinoma. Different minimum criteria exist for the diagnosis of SSLs and their differentiation from HPs. Furthermore, the spectrum of terminology used to describe the entire range of serrated lesions is wide. This variability has impaired interobserver agreement during their histopathological assessment. Here, we provide guidance for the histopathological reporting of serrated lesions, including a simplified nomenclature system. Essentially, we recommend use of the following terms: HP, SSL, SSL with dysplasia, traditional serrated adenoma (TSA) and mixed polyp. It is hoped that this standardisation of nomenclature will facilitate studies of the biological significance of serrated lesions in terms of the relative risk of disease progression.
Department of Cellular Pathology, Southampton General Hospital, Southampton, UK.
Adrian C
http://orcid.org/0000-0003-2222-4104
AC
Bateman
Gloucestershire Cellular Pathology Laboratory, Cheltenham General Hospital, Cheltenham, UK.
Neil A
NA
Shepherd
D000230:Adenocarcinoma / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D018256:Adenomatous Polyps / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy / Q000592:standards; D003111:Colonic Polyps / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry / Q000592:standards; D015588:Observer Variation; D010338:Pathology, Clinical / Q000592:standards*; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D009626:Terminology as Topic; D006113:United Kingdom
D014408:Biomarkers, Tumor
COLON; COLORECTAL CANCER; RECTUM; diagnostic screening