Chemical components from the haulm of Artemisia selengensis and the inhibitory effect on glycation of β-lactoglobulin.
Artemisia selengensis (AS) has been traditionally used as both food and medicine for thousands of years in China. In our studies, l-tryptophan was first isolated from the haulm of AS together with luteolin, rutin, and kaempferol-3-O-glucuronide. Their structures were elucidated by spectroscopic methods including HRMS, 1D and 2D NMR. Three flavonoid compounds showed satisfactory suppression effects on the formation of advanced glycation end products (AGEs) in β-lactoglobulin-lactose/MGO/GO model systems, and their anti-glycation activities exhibited a dose-dependent manner. Among these compounds, kaempferol-3-O-glucuronide was demonstrated to be the strongest inhibitor against the formation of AGEs.
Department of Food Science and Technology, Ginling College, Nanjing Normal University, 122# Ninghai Road, Nanjing, 210097, P. R. China. lishuanglv@126.com lulishuang@njnu.edu.cn.
Xiaoming
X
Li
Yonglin
Y
Lu
Ronghua
R
Deng
Tiesong
T
Zheng
Lishuang
L
Lv
D000818:Animals; D019306:Artemisia / Q000737:chemistry* / Q000254:growth & development; D002681:China; D018556:Crops, Agricultural / Q000737:chemistry* / Q000254:growth & development; D019448:Ethnobotany; D020834:Ethnopharmacology; D005419:Flavonoids / Q000032:analysis / Q000737:chemistry / Q000191:economics / Q000302:isolation & purification*; D005520:Food Preservatives / Q000032:analysis / Q000737:chemistry / Q000191:economics / Q000302:isolation & purification*; D005525:Food-Processing Industry / Q000191:economics; D020719:Glucuronides / Q000032:analysis / Q000737:chemistry / Q000191:economics / Q000302:isolation & purification; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors* / Q000737:chemistry; D006031:Glycosylation; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D007220:Industrial Waste / Q000032:analysis / Q000191:economics; D044949:Kaempferols / Q000032:analysis / Q000737:chemistry / Q000191:economics / Q000302:isolation & purification; D007782:Lactoglobulins / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000191:economics / Q000302:isolation & purification; D018547:Plant Stems / Q000737:chemistry* / Q000254:growth & development
D005419:Flavonoids; D005520:Food Preservatives; D020719:Glucuronides; D017127:Glycation End Products, Advanced; D007220:Industrial Waste; D044949:Kaempferols; D007782:Lactoglobulins; D010936:Plant Extracts; D007785:Lactose