Tailoring specialized metabolite production in streptomyces.
Streptomycetes are prolific producers of a plethora of medically useful metabolites. These compounds are made by complex secondary (specialized) metabolic pathways, which utilize primary metabolic intermediates as building blocks. In this review we discuss the evolution of specialized metabolites and how expansion of gene families in primary metabolism has lead to the evolution of diversity in these specialized metabolic pathways and how developing a better understanding of expanded primary metabolic pathways can help enhance synthetic biology approaches to industrial pathway engineering.
Strathclyde Institute of Pharmacy and Biological Science, University of Strathclyde, Glasgow, UK.
Jana K
JK
Hiltner
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Iain S
IS
Hunter
Strathclyde Institute of Pharmacy and Biological Science, University of Strathclyde, Glasgow, UK.
Paul A
PA
Hoskisson
D016680:Genome, Bacterial; D060847:Metabolic Engineering; D053858:Metabolic Networks and Pathways; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*; D058615:Synthetic Biology
Antibiotics; Evolution; Metabolic engineering; Metabolism; Streptomyces