Understanding Brugada syndrome.
Brugada syndrome is an established cause of sudden cardiac arrest in patients without structural cardiac abnormalities. Recognition and diagnosis of this syndrome has been slowly increasing. Syncope, ventricular dysrhythmia, or sudden cardiac arrest may be the presenting symptom, although detection of the characteristic right precordial ST-segment elevation on ECG can be a potentially lifesaving intervention. This article reviews the clinical presentation, pathophysiology, genetics, and current management of Brugada syndrome.
Janine Mary Gehshan practices in the cardiac electrophysiology laboratory at New York University Langone Medical Center and works per diem in the postanesthesia care unit at Memorial Sloan Kettering Cancer Center, both in New York City. She is a recent graduate of the Pace completion program in New York City. Denise Rizzolo is an assistant clinical professor in the Pace completion program, an associate professor in the PA program at Seton Hall University in South Orange, N.J., and practices urgent care in Springfield, N.J. The authors have disclosed no potential conflicts of interest, financial or otherwise.
Janine Mary
JM
Gehshan
Denise
D
Rizzolo
D053840:Brugada Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics / Q000628:therapy; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D006801:Humans; D013575:Syncope / Q000209:etiology / Q000517:prevention & control*