Oral Cyclosporine Weekend Therapy: A New Maintenance Therapeutic Option in Patients with Severe Atopic Dermatitis.
Cyclosporine A (CyA) is a systemic therapy used to control severe atopic dermatitis (AD) in children, but its use may be associated with serious side effects. Intermittent short-course therapy has been used to minimize these risks without the loss of clinical benefits. We conducted a 20-week study using intermittent short-course CyA therapy in five patients with severe AD and a Scoring Atopic Dermatitis (SCORAD) score >40. The result was a reduction in the cumulative dose of CyA and serum CyA level, which allows for a longer duration of CyA treatment and decreases the risk of relapse in patients with severe AD.
Departments of Dermatology and Venereology, Virgen de Las Nieves Hospital, Granada, Spain.
Cristina
C
Garrido Colmenero
Departments of Dermatology and Venereology, Virgen de Las Nieves Hospital, Granada, Spain.
Gonzalo
G
Blasco Morente
Departments of Dermatology and Venereology, Virgen de Las Nieves Hospital, Granada, Spain.
Jesús
J
Tercedor Sánchez
D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine