The aging prostate is never "normal": implications from the genomic characterization of multifocal prostate cancers.
We argue against the recently published statement that tumor-specific molecular alterations found in "normal" prostate tissue from cancer patients challenge focal therapy approaches that only target a visible cancer lesion and not the adjacent molecular field.
Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: tschlomm@uke.de.
Thorsten
T
Schlomm
Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Joachim
J
Weischenfeldt
Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Jan
J
Korbel
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Guido
G
Sauter
D000375:Aging / Q000235:genetics* / Q000378:metabolism; D018740:Genetic Heterogeneity; D023281:Genomics; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000378:metabolism; D015514:Oncogene Proteins, Fusion / Q000378:metabolism; D011467:Prostate / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism
D015514:Oncogene Proteins, Fusion; C515553:TMPRSS2-ERG fusion protein, human