Parameters of prostate cancer at contrast-enhanced ultrasound: correlation with prostate cancer risk.
OBJECTIVE
to investigate the correlation between the parameters of prostate cancer (PCa) at contrast-enhanced ultrasound (CEUS) with PCa risk.


METHODS
84 patients (68 ± 8 years; range, 33-79 years) who had undergone CEUS were included. All the images were offline analyzed. Parameters (maximum intensity (IMAX), rise time (RT), time to peak (TTP) and mean transit time (mTT)) were recorded and compared with PSA level, Gleason score, clinical stages and PCa risk.


RESULTS
Age was correlated significantly with PCa risk. RT and mTT of outer gland were associated with PCa risk. No significant correlation was found between PSA and CEUS enhancement parameters. Furthermore, with the exception of IMAX of inner gland and IMAX of outer gland, there were no significant differences of enhancement parameters in Gleason score groups and clinical stages groups.


CONCLUSIONS
The enhancement parameters of PCa at CEUS may be used to predict PCa risk. And it is helpful for the choice of therapeutic options.
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
Guang
G
Xu
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
Jian
J
Wu
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
Ming-Hua
MH
Yao
Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
Xu-Dong
XD
Yao
Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
Bo
B
Peng
Department of Pathology, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
Qing
Q
Wei
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China ; State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences Shanghai 200050, China.
Hui-Xiong
HX
Xu
Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine Shanghai 200072, China.
Rong
R
Wu
Contrast-enhanced ultrasound; prostate cancer; prostate cancer risk