A misdiagnosed melanoma: a case of cutaneous epithelioid malignant peripheral nerve sheath tumor.
Malignant Peripheral Nerve Sheath Tumor (MPNST) is a rare soft tissue sarcoma that can occur in superficial locations. Histologically it is categorized into two variants: a conventional/spindled and an epithelioid variant. The latter one is very rare and can be confused histologically with malignant melanoma as it is diffusely positive for S100-protein. Herein we present a case that was initially misdiagnosed as malignant melanoma and discuss morphological and immunohistochemical clues to reach a correct diagnosis.
Department of Pathology/Division of Dermatopathology, Indiana University.
Konstantinos
K
Linos
Simon
S
Warren
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008545:Melanoma / Q000473:pathology*; D018317:Nerve Sheath Neoplasms / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D000096142:Cutaneous Malignant Melanoma
D014408:Biomarkers, Tumor