Neuroprotective effect of resveratrol against glutamate-induced excitotoxicity.
As the major neurotransmitter in the mammalian central nervous system (CNS), excessive extracellular glutamate (Glu) can activate the Glu receptors and neuronal calcium (Ca2+) overload, then produce neurotoxicity, which is a common pathway for neuronal injury or death, and is associated with acute and chronic neurodegenerative diseases. Therefore, it has been a therapeutic strategy to investigate neuroprotective effects against Glu-induced neurotoxicity for treating both acute and chronic forms of neurodegeneration. Resveratrol (Res), as a naturally occurring polyphenol mainly found in grapes and red wine, has shown a neuroprotective effect in a variety of experimental models for neurodegenerative diseases in vitro and in vivo. This review will focus on the neuroprotective effect of Res against Glu-induced excitotoxicity in neurodegenerative diseases by blocking different Glu receptors and Ca2+ ion channels.
Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China; State Key Laboratory Breeding Base, Hebei Province Key Laboratory of Molecular Chemistry for Drugs, Shijiazhuang, Hebei, China.
Li-Nan
LN
Zhang
Department of Neurosurgery, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.
Liang
L
Hao
Pharmaceutical Preparation Section, Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.
Hai-Yan
HY
Wang
Pharmaceutical Preparation Section, Fourth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China.
Hong-Ning
HN
Su
Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China; State Key Laboratory Breeding Base, Hebei Province Key Laboratory of Molecular Chemistry for Drugs, Shijiazhuang, Hebei, China.
Yong-Jun
YJ
Sun
Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China.
Xiao-Yue
XY
Yang
Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China.
Bin
B
Che
Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China.
Jiao
J
Xue
Pharmacy Department, Hebei University of Science and Technology, Shijiazhuang, Hebei, China; State Key Laboratory Breeding Base, Hebei Province Key Laboratory of Molecular Chemistry for Drugs, Shijiazhuang, Hebei, China.
Zi Bin
ZB
Gao
D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018091:Receptors, AMPA / Q000378:metabolism; D018092:Kainic Acid Receptors / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
D002118:Calcium; D015220:Calcium Channels; D018691:Excitatory Amino Acid Antagonists; D018698:Glutamic Acid; D018696:Neuroprotective Agents; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; D000077185:Resveratrol; D013267:Stilbenes