COX inhibition reduces vasodilator PGE2 but is shown to increase levels of chemoattractant 12-HETE in vivo in human sunburn.
Centre for Dermatology, Institute of Inflammation and Repair, University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Suzanne M
SM
Pilkington
Manchester Pharmacy School, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
Sharon A
SA
Murphy
Centre for Dermatology, Institute of Inflammation and Repair, University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Shobha
S
Kudva
Manchester Pharmacy School, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
Anna
A
Nicolaou
Centre for Dermatology, Institute of Inflammation and Repair, University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Lesley E
LE
Rhodes
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / Q000378:metabolism*; D000328:Adult; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D015232:Dinoprostone / Q000378:metabolism*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D019272:Leukocyte Elastase / Q000032:analysis; D008297:Male; D009504:Neutrophils; D013471:Sunburn / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects; D055815:Young Adult
D016861:Cyclooxygenase Inhibitors; D006454:Hemoglobins; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D019272:Leukocyte Elastase; D015232:Dinoprostone; D007213:Indomethacin
12-hydroxyeicosatetraenoic acid; 12-lipoxygenase; E2; cyclooxygenase prostaglandin; ultraviolet radiation