HIV infection presenting proliferation of CD8+ T lymphocyte and hemophagocytic lymphohistiocytosis.
Hemophagocytic lymphohistiocytosis is a rare hyperinflammatory disorder characterised by CD8+ T lymphocyte activation and hypercytokinemia. Autoimmune disorders including hemophagocytic lymphohistiocytosis have been described in HIV patients; however, it is a rare initial presentation of HIV infection. We present an unusual case of HIV infection presenting with hemophagocytic lymphohistiocytosis.
Henry Ford Hospital, Detroit, MI, USA.
Mohammad
M
Usman
Henry Ford Hospital, Detroit, MI, USA sthapa1@hfhs.org dr.sdthapa@gmail.com.
Sudeep D
SD
Thapa
Henry Ford Hospital, Detroit, MI, USA.
Hiba
H
Hadid
Henry Ford Hospital, Detroit, MI, USA.
Lenar T
LT
Yessayan
D023241:Antiretroviral Therapy, Highly Active; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology*; D018414:CD8-Positive T-Lymphocytes / Q000821:virology*; D005921:Glomerulonephritis / Q000150:complications; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D010198:Pancytopenia / Q000175:diagnosis; D055815:Young Adult
AIDS; HIV; HLH; acute retroviral syndrome; hemophagocytic lymphohistiocytosis