A direct access to heptasubstituted biguanides.
An efficient and experimentally simple copper-catalyzed carbon-nitrogen bond formation for the synthesis of [Formula: see text]-arylated biguanides starting from aryl halides, carbodiimides, and 1,1,3,3-tetramethylguanidine is reported. The potential diversity of this type of reaction, easily available starting materials, and commercially available low-cost catalysts are the incremental features of this methodology.
Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran. yavarisa@modares.ac.ir.
Issa
I
Yavari
Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran.
Manijeh
M
Nematpour
D001645:Biguanides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure
D001645:Biguanides; D003300:Copper
-Arylation; Biguanides; Carbodiimides; Copper-catalyzed; Tetramethylguanidine