Type 2 diabetic rats on diet supplemented with chromium malate show improved glycometabolism, glycometabolism-related enzyme levels and lipid metabolism.
Our previous study showed that chromium malate improved the regulation of blood glucose in mice with alloxan-induced diabetes. The present study was designed to evaluate the effect of chromium malate on glycometabolism, glycometabolism-related enzymes and lipid metabolism in type 2 diabetic rats. Our results showed that fasting blood glucose, serum insulin level, insulin resistance index and C-peptide level in the high dose group had a significant downward trend when compared with the model group, chromium picolinate group and chromium trichloride group. The hepatic glycogen, glucose-6-phosphate dehydrogenase, glucokinase, Glut4, phosphor-AMPKβ1 and Akt levels in the high dose group were significantly higher than those of the model, chromium picolinate and chromium trichloride groups. Chromium malate in a high dose group can significantly increase high density lipoprotein cholesterol level while decreasing the total cholesterol, low density lipoprotein cholesterol and triglyceride levels when compared with chromium picolinate and chromium trichloride. The serum chromium content in chromium malate and chromium picolinate group is significantly higher than that of the chromium trichloride group. The results indicated that the curative effects of chromium malate on glycometabolism, glycometabolism-related enzymes and lipid metabolism changes are better than those of chromium picolinate and chromium trichloride. Chromium malate contributes to glucose uptake and transport in order to improved glycometabolism and glycometabolism-related enzymes.
School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Weiwei
W
Feng
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Ting
T
Zhao
School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Guanghua
G
Mao
School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Wei
W
Wang
School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Yun
Y
Feng
School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Fang
F
Li
School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Daheng
D
Zheng
School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu, China.
Huiyu
H
Wu
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Dun
D
Jin
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Liuqing
L
Yang
School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Xiangyang
X
Wu
D000818:Animals; D001692:Biological Transport; D001786:Blood Glucose; D001835:Body Weight; D002857:Chromium / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000378:metabolism*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005215:Fasting; D000069196:Gastrointestinal Microbiome / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D008293:Malates / Q000494:pharmacology; D008297:Male; D018782:Maze Learning; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D008293:Malates; D002857:Chromium; C030298:malic acid; D006003:Glycogen; D005947:Glucose