[Effect of a large scale community-based distribution of artemether-lumefantrine on its therapeutic efficacy among children living in a rural area of Burkina Faso].
This study aimed to assess the effect of an integrated community case management of malaria and pneumonia programme (iCCMmp) on the efficacy of artemether-lumefantrine (AL). Thus, we carried out two open label and unique centre clinical trials, before and after the iCCMmp, on the therapeutic efficacy of AL. A total of 210 children aged 6-59 months, were included in the study, 105 before and 105 after the iCCMmp. The adequate clinical and parasitological response was 90.5% and 86.7% respectively before and after the iCCMmp (p value = 0.516). Our findings reported no effect of iCCMmp on the therapeutic efficacy of the AL.
Groupe de recherche action en santé (GRAS), 06 BP 10248, Ouagadougou 06, Burkina Faso, gras@fasonet.bf.
M
M
Siribié
A
A
Diarra
A B
AB
Tiono
I
I
Soulama
S B
SB
Sirima
D000962:Antimalarials / Q000627:therapeutic use*; D000077549:Artemether; D037621:Artemisinins / Q000627:therapeutic use*; D002050:Burkina Faso / Q000453:epidemiology; D002675:Child, Preschool; D003695:Delivery of Health Care / Q000706:statistics & numerical data; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005449:Fluorenes / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D000078102:Lumefantrine; D008288:Malaria / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male; D011156:Population Density; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012424:Rural Population / Q000706:statistics & numerical data; D018401:Sample Size; D016896:Treatment Outcome
D000962:Antimalarials; D037621:Artemisinins; D004983:Ethanolamines; D005449:Fluorenes; D000077549:Artemether; D000078102:Lumefantrine