Focused ultrasound-mediated drug delivery through the blood-brain barrier.
Despite recent advances in blood-brain barrier (BBB) research, it remains a significant hurdle for the pharmaceutical treatment of brain diseases. Focused ultrasound (FUS) is one method to transiently increase permeability of the BBB to promote drug delivery to specific brain regions. An introduction to the BBB and a brief overview of the methods, which can be used to circumvent the BBB to promote drug delivery, is provided. In particular, we discuss the advantages and limitations of FUS technology and the efficacy of FUS-mediated drug delivery in models of disease. MRI for targeting and evaluating FUS treatments, combined with administration of microbubbles, allows for transient, reproducible BBB opening. The integration of a real-time acoustic feedback controller has improved treatment safety. Successful clinical translation of FUS has the potential to transform the treatment of brain disease worldwide without requiring the development of new pharmaceutical agents.
Physical Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S665, Toronto, ON M4N 3M5, Canada.
Alison
A
Burgess
Kairavi
K
Shah
Olivia
O
Hough
Kullervo
K
Hynynen
D000818:Animals; D001812:Blood-Brain Barrier / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D045423:Microbubbles; D000069453:Ultrasonic Waves
blood–brain barrier; drug delivery; focused ultrasound; neurodegenerative disease