Clinical literature review of 1858 Crohn's disease cases requiring surgery in China.
OBJECTIVE
To summarize the clinical characteristics of Crohn's disease (CD) patients who underwent surgery in China.


METHODS
We searched four main Chinese electronic databases: CBM, VIP, CNKI, and Wanfang (from January 1990 to October 2013). Then, we selected and carefully read 97 studies and extracted the surgical data for CD. We found that 1858 patients with CD underwent surgery between 1961 and 2012. The patients were stratified into two groups according to the year of surgery: 1961-2000 and 2000-2012. The clinical characteristics of these CD cases were compared between the two groups.


RESULTS
The mean age at the time of surgery was 38.13 years. The most common locations of disease were the small intestine (40.84%), the colon (33.60%) and the ileocolon (23.09%). The primary indications for surgery were intestinal obstruction or stricture (23.84%), failure of drug therapy (14.80%), acute abdominal disease (13.46%), abdominal mass (10.93%), intestinal fistulae (9.90%), intestinal perforation (8.45%), perianal disease (6.73%), gastrointestinal bleeding (4.79%), and abdominal abscess (4.04%). The rate of diagnosis of CD before surgery was low (34.78%), and the misdiagnosis rate was 20.49%. The predominant surgical procedure for CD was bowel resection (69.54%). The rate of surgical complications was 20.34%, and the primary complications of surgery were infection (39.44%) and intestinal fistulae (26.09%). The relapse rate after surgery was 27.71%. For the periods of 1961-2000 and 2000-2013, the rates of both misdiagnosis before surgery and surgery related-death decreased (34.90% vs 12.10%, P < 0.001, and 23.53% vs 5.26%, P < 0.001, respectively).


CONCLUSIONS
The rates of surgical complications and misdiagnosis were higher, whereas the rate of CD-associated tumor and the relapse rate were lower in China than in West countries.
Qing-Hai Peng, Yu-Fang Wang, Man-Qing He, Cui Zhang, Qin Tang, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Qing-Hai
QH
Peng
Qing-Hai Peng, Yu-Fang Wang, Man-Qing He, Cui Zhang, Qin Tang, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Yu-Fang
YF
Wang
Qing-Hai Peng, Yu-Fang Wang, Man-Qing He, Cui Zhang, Qin Tang, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Man-Qing
MQ
He
Qing-Hai Peng, Yu-Fang Wang, Man-Qing He, Cui Zhang, Qin Tang, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Cui
C
Zhang
Qing-Hai Peng, Yu-Fang Wang, Man-Qing He, Cui Zhang, Qin Tang, Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Qin
Q
Tang
D000328:Adult; D002681:China / Q000453:epidemiology; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D003951:Diagnostic Errors; D013505:Digestive System Surgical Procedures / Q000009:adverse effects / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D011237:Predictive Value of Tests; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
Crohn’s disease; Surgery; Surgical complications; Surgical indications; Surgical recurrence