Structural Insights into tRNA Dynamics on the Ribosome.
High-resolution structures at different stages, as well as biochemical, single molecule and computational approaches have highlighted the elasticity of tRNA molecules when bound to the ribosome. It is well acknowledged that the inherent structural flexibility of the tRNA lies at the heart of the protein synthesis process. Here, we review the recent advances and describe considerations that the conformational changes of the tRNA molecules offer about the mechanisms grounded in translation.
Structural Biology Unit, CICbioGUNE Biscay Technology Park, Bld 800, 48610 Derio, Basque Country, Spain. xagirrezabala@cicbiogune.es.
Xabier
X
Agirrezabala
Structural Biology Unit, CICbioGUNE Biscay Technology Park, Bld 800, 48610 Derio, Basque Country, Spain. mvalle@cicbiogune.es.
Mikel
M
Valle
D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D012343:RNA, Transfer / Q000737:chemistry* / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*
D012343:RNA, Transfer