Warm autoimmune hemolytic anemia with mimicking anti-e specificity causing intravascular hemolysis in a chronic ITP patient.
A 12-year-old male child presented to the emergency room with three days history of cola-colored urine, mild icterus, dyspnea, palpitation and fatigue. He had a history of chronic ITP two years ago and had since been on steroid for maintenance of platelet count. He was subsequently diagnosed as a case of warm autoimmune hemolytic anemia. Laboratory investigations were suggestive of intravascular hemolysis, and on immuno-hematological evaluation it was diagnosed that the patient had autoantibody with mimicking anti-e specificity. The specificity of autoantibody was further confirmed by adsorption study. The patient was successfully managed by transfusion of Rh(e)-negative red cells,steroid and rituximab therapy. So an autoantibody with mimicking anti-e specificity was identified in this case, which was significant in clinical point of view.
Department of Transfusion Medicine, Tata Medical Center, Newtown, Rajarhat, Kolkata, West Bengal, India. Electronic address: suvro.datta@gmail.com.
Suvro Sankha
SS
Datta
Department of Transfusion Medicine, Tata Medical Center, Newtown, Rajarhat, Kolkata, West Bengal, India.
Mahua
M
Reddy
Department of Transfusion Medicine, Tata Medical Center, Newtown, Rajarhat, Kolkata, West Bengal, India.
Sabita
S
Basu
D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000628:therapy; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002908:Chronic Disease; D017707:Erythrocyte Transfusion; D006461:Hemolysis; D006801:Humans; D007073:Immunoglobulin E; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000628:therapy; D000069283:Rituximab / Q000008:administration & dosage*; D013256:Steroids / Q000008:administration & dosage*
D001323:Autoantibodies; D013256:Steroids; D007073:Immunoglobulin E; D000069283:Rituximab
Autoantibody; Mimicking specificity; Warm autoimmune hemolytic anemia