Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective Hydroboration of α-Arylenamides.
The rhodium-catalyzed asymmetric hydroboration of α-arylenamides with BI-DIME as the chiral ligand and (Bpin)2 as the reagent yields for the first time a series of α-amino tertiary boronic esters in good yields and excellent enantioselectivities (up to 99% ee).
State Key Laboratory of Bio-Organic and Natural Products Chemistry and Collaborative Innovation Center of Chemistry for life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, China.
Naifu
N
Hu
State Key Laboratory of Bio-Organic and Natural Products Chemistry and Collaborative Innovation Center of Chemistry for life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, China.
Guoqing
G
Zhao
State Key Laboratory of Bio-Organic and Natural Products Chemistry and Collaborative Innovation Center of Chemistry for life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, China.
Yuanyuan
Y
Zhang
State Key Laboratory of Bio-Organic and Natural Products Chemistry and Collaborative Innovation Center of Chemistry for life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, China.
Xiangqian
X
Liu
State Key Laboratory of Bio-Organic and Natural Products Chemistry and Collaborative Innovation Center of Chemistry for life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, China.
Guangyu
G
Li
State Key Laboratory of Bio-Organic and Natural Products Chemistry and Collaborative Innovation Center of Chemistry for life Sciences, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, China.
Wenjun
W
Tang
D000577:Amides / Q000737:chemistry*; D001897:Boronic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000577:Amides; D001897:Boronic Acids; D004952:Esters