One-pot synthesis of antibacterial chitosan/silver bio-nanocomposite hydrogel beads as drug delivery systems.
Silver nanoparticles were synthesized in situ during the formation of physically crosslinked chitosan hydrogel beads using sodium tripolyphosphate as the crosslinker. The aim of the study was to investigate whether these nanocomposite beads have the potential to be used in drug delivery applications. The formation of silver nanoparticles (AgNPs) in the hydrogels was confirmed by X-ray diffraction and scanning electron microscopy studies. Furthermore, the antibacterial and swelling properties of the beads were studied. The nanocomposite hydrogels demonstrated good antibacterial effects against Escherichia coli and Staphylococcus aureus bacteria. AgNPs caused an increase in the swelling capacity of the beads. In vitro drug release test was carried out to prove the effectiveness of this novel type of nanocomposite beads as a controlled drug delivery system. Prolonged and more controlled drug releases were observed for AgNPs containing chitosan beads, which increased by the increase in AgNPs content.
Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666-16471, Tabriz, Iran.
Mehdi
M
Yadollahi
Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666-16471, Tabriz, Iran.
Sana
S
Farhoudian
Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666-16471, Tabriz, Iran; Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Science, Tabriz, Iran. Electronic address: namazi@tabrizu.ac.ir.
Hassan
H
Namazi
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D052978:Disk Diffusion Antimicrobial Tests; D004339:Drug Compounding; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D020100:Hydrogels / Q000737:chemistry; D007052:Ibuprofen / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D011122:Polyphosphates / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D003432:Cross-Linking Reagents; D020100:Hydrogels; D011122:Polyphosphates; D012834:Silver; D048271:Chitosan; C005692:triphosphoric acid; D007052:Ibuprofen
Antibacterial; Bio-nanocomposite; Chitosan bead; Drug delivery; Silver nanoparticle