Are renal ciliopathies (replication) stressed out?
Juvenile renal failure is commonly caused by the ciliopathy nephronophthisis (NPHP). Since all NPHP genes regulate cilia function, it has been assumed that NPHP onset is due to cilia loss. However, recent data suggest that DNA damage caused by replication stress, possibly concomitant with or upstream of cilia dysfunction, causes NPHP.
Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands.
Gisela G
GG
Slaats
Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: r.giles@umcutrecht.nl.
Rachel H
RH
Giles
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002923:Cilia / Q000473:pathology*; D004249:DNA Damage / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000378:metabolism*
DNA damage; cell cycle; cilia; cyclin-dependent kinase; fibrosis; kidney cysts; replication stress