Multiparametric Prostate Magnetic Resonance Imaging at 3 T: Failure of Magnetic Resonance Spectroscopy to Provide Added Value.
OBJECTIVE
To assess the effect of proton magnetic resonance spectroscopy imaging (MRSI) on the accuracy of multiparametric magnetic resonance imaging (mpMRI) at 3 T for prostate cancer detection.


METHODS
Thirty-four patients with prostate cancer were included in this retrospective study. All patients underwent preoperative mpMRI on a 3-T scanner before radical prostatectomy. Magnetic resonance imaging evaluation was based on the prostate imaging-reporting and data system classification system. The accuracy of mpMRI with and without MRSI was determined using receiver operating characteristic analysis, with histology as the reference standard.


RESULTS
Multiparametric MRI including MRSI had a sensitivity of 57.0% and a specificity of 89.2% for sextant-based cancer detection. Multiparametric MRI without MRSI had a sensitivity of 58.1% and a specificity of 87.4%. There was no significant difference regarding the accuracy of mpMRI with and without MRSI (P = 0.48).


CONCLUSIONS
The addition of MRSI does not improve the accuracy of 3 T mpMRI for sextant localization of prostate cancer.
From the Departments of *Radiology, †Urology, and ‡Pathology, Dresden University Hospital, Dresden, Germany.
Ivan
I
Platzek
Angelika
A
Borkowetz
Marieta
M
Toma
Thomas
T
Brauer
Christoph
C
Meissner
Katrin
K
Dietel
Manfred
M
Wirth
Michael
M
Laniado
D000368:Aged; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity