The association between N-terminal pro B-type natriuretic peptide and lipoprotein particle concentration plateaus at higher N-terminal pro B-type natriuretic peptide values: Multi-Ethnic Study on Atherosclerosis.
BACKGROUND
The association between N-terminal pro B-type natriuretic peptide (NT-proBNP) and blood levels of small and large LDL- and HDL- particle (P) concentration may not be linear throughout the whole range of NT-proBNP values.


METHODS
Linear spline regression analysis between NT-proBNP and lipoprotein particle concentrations was performed cross-sectionally in 5597 individuals from the Multi-Ethnic Study of Atherosclerosis adjusted for age, race, sex, body mass index, % of energy from saturated fats, intentional exercise, statin use, antihypertensive medication use, diabetes, IL-6 and estimated glomerular filtration rate. Spline knots were selected as the point at which the linear slope changed in these associations.


RESULTS
NT-proBNP was positively associated with large LDL-P and HDL-P, but inversely associated with small LDL-P and HDL-P, but only for NT-proBNP values below the knot (range: 100-200 pg/mL).


CONCLUSIONS
These results suggest the presence of two distinct biological mechanisms above and below the knot determining the association between NT-proBNP and lipoprotein particle concentrations.
School of Public Health, Division of Epidemiology & Community Health, University of Minnesota. Electronic address: sanc0050@umn.edu.
Otto A
OA
Sanchez
Division of Cardiology, University of Minnesota.
Daniel A
DA
Duprez
Division of Cardiology, University of California, San Diego.
Lori B
LB
Daniels
School of Medicine, University of California, San Diego; and Veterans Affairs San Diego Healthcare System.
Alan S
AS
Maisel
LipoScience. Inc. Raleigh, North Carolina.
James D
JD
Otvos
School of Medicine, University of California San Francisco.
Carmen A
CA
Peralta
Division of Cardiology, Johns Hopkins Bayview Medical Center.
João A
JA
Lima
MPH Stanford Cardiology Division, Stanford School of Medicine.
Hossein
H
Bahrami
School of Public Health, Division of Epidemiology & Community Health, University of Minnesota.
David R
DR
Jacobs
D050197:Atherosclerosis / Q000097:blood*; D003430:Cross-Sectional Studies; D006801:Humans; D016014:Linear Models; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
Lipoprotein particles; MESA study; NT-proBNP; Nuclear magnetic resonance spectroscopy