Advances in the proinflammatory effects of visfatin and its relationship with diabetic kidney disease.
Visfatin, also known as the pre-B-cell colony enhancing factor, is a new member of the adipocytokines. It serves as a nicotinamide phosphoribosyltransferase in cells. Visfatin has complex biological functions and may be involved in the pathogenesis of diabetic kidney disease; it may contribute to the chronic inflammatory status at systemic and renal levels and thus aggravate renal injury. Further research on visfatin will provide new insights in the treatment of diabetic kidney disease. This article reviews the recent advances in the proinflammatory effects of visfatin and its relationship with diabetic kidney disease.
Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Liang-yan
LY
Zhang
Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Xue-mei
XM
Li
D016207:Cytokines; D003928:Diabetic Nephropathies; D006801:Humans; D054409:Nicotinamide Phosphoribosyltransferase
D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human