Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study.
Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: (1) rs7794745 (A/A or A/T), (2) rs2710102 [G/G or A carrier (A/G and A/A)], and (3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals.
Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.
Michihiko
M
Koeda
Division of Personalized Genetic Medicine, Nippon Medical School Hospital Tokyo, Japan ; Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.
Atsushi
A
Watanabe
Department of Biofunctional Informatics, Tokyo Medical and Dental University Tokyo, Japan.
Kumiko
K
Tsuda
Department of Biofunctional Informatics, Tokyo Medical and Dental University Tokyo, Japan.
Miwako
M
Matsumoto
Department of Pediatric Dentistry, Nippon Dental University Tokyo, Japan.
Yumiko
Y
Ikeda
Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.
Woochan
W
Kim
Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.
Amane
A
Tateno
Division of Personalized Genetic Medicine, Nippon Medical School Hospital Tokyo, Japan ; Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.
Banyar Than
BT
Naing
Department of Pediatric Dentistry, Nippon Dental University Tokyo, Japan.
Hiroyuki
H
Karibe
Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.
Takashi
T
Shimada
Department of Pharmacology, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.
Hidenori
H
Suzuki
Department of Biofunctional Informatics, Tokyo Medical and Dental University Tokyo, Japan.
Masato
M
Matsuura
Department of Neuropsychiatry, Graduate School of Medicine, Nippon Medical School Tokyo, Japan.
Yoshiro
Y
Okubo
CNTNAP2; SNPs; autism; fMRI; handedness; schizophrenia; voice