Increased interleukin 1 and tumor necrosis factor alpha levels after thyroid surgery.
OBJECTIVE
The aim of this study was to consider levels of the proinflammatory cytokines IL-1 and TNFα after thyroid surgery.


METHODS
A total of 200 patients who underwent total thyroidectomy enrolled in this study. Drain fluid samples were taken. IL-1 and TNFα results and their relationship with other factors were analyzed.


RESULTS
There was a positive correlation between IL-1 and hyperthyroidism (rs=0.614, p<0.001), operative time (rs=0.770, p<0.001), and excised thyroid volume (rs=0.829, p<0.001). Moreover, there was a positive correlation between TNFα and hyperthyroidism (rs=0.430, p<0.001), operative time (rs=0.392, p<0.001), and excised thyroid volume (rs=0.398, p<0.001).


CONCLUSIONS
The results of this study showed us that the parameters related to increased proinflammatory cytokine levels after thyroid surgery were hyperthyroidism, operative time, and excised thyroid volume, but this increase did not show us any clinical outcomes related to these parameters.
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
Beyza
B
Özçınar
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
Nihat
N
Aksakal
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
Fatih
F
Yanar
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
Orhan
O
Ağcaoğlu
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
Kıvanç Derya
KD
Peker
Department of Biochemistry, İstanbul University, İstanbul Faculty of Medicine, İstanbul, Turkey.
Ümit
Ü
Türkoğlu
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
Selçuk
S
Mercan
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
Selçuk
S
Özarmağan
Department of General Surgery, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey.
Yeşim
Y
Erbil
IL-1; TNFα; Total thyroidectomy; proinflammatory cytokines; thyroid surgery