Amurensiosides L-P, five new cardenolide glycosides from the roots of Adonis amurensis.
Five new cardenolide glycosides, amurensiosides L-P (1-5), were isolated from the roots of Adonis amurensis. Their structures were determined based on extensive spectroscopic analysis, including two-dimensional (2D) NMR data, and on the results of hydrolytic cleavage. Compounds 1-5 were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia and HSC-2 human oral squamous cell carcinoma cell lines.
Satoshi
S
Kubo
Minpei
M
Kuroda
Akihito
A
Yokosuka
Hiroshi
H
Sakagami
Yoshihiro
Y
Mimaki
D031843:Adonis / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D002298:Cardenolides / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D006027:Glycosides