Relationship between NF-κB, MMP-9, and MICA expression in pituitary adenomas reveals a new mechanism of pituitary adenomas immune escape.
The aim of this study was to examine the expression levels of NF-κB, MMP-9, and MICA and their relationship between each other in pituitary adenomas as a histological basis for the study of the expression and shedding mechanism of MICA and mechanism of immune escape of pituitary adenomas. Our study indicated that MICA, MMP-9 and NF-κB mRNA and protein levels were more highly expressed in pituitary adenomas than healthy tissues. The expression levels of NF-κB, MMP-9, and MICA were positively related in patients with pituitary adenomas. In conclusion, the activation of NF-κB can up-regulate the expression of MICA and induce the expression of MMP-9, which hydrolyzes MICA into sMICA to promote tumor immune escape. The interactions of NF-κB, MMP-9, and MICA play an important role in the development of pituitary adenomas, and MMP-9 could be used as a new target for inhibiting tumor cell immune escape.
Neurosurgery, Binzhou Medical University Affiliated Hospital, 661Huanghe second Road, Binzhou, Shandong Province 256600, China.
Zheng
Z
Chen
Neurosurgery, Binzhou Medical University Affiliated Hospital, 661Huanghe second Road, Binzhou, Shandong Province 256600, China.
Zhenzhu
Z
Li
Institute of Human Anatomy and Histology and Embryology, Otology & Neuroscience Center, Binzhou Medical University, 346 Guanhai Road, Laishan District, Shandong Province 264003, China.
Yingwei
Y
Chang
Neurosurgery, Binzhou Medical University Affiliated Hospital, 661Huanghe second Road, Binzhou, Shandong Province 256600, China.
Lixin
L
Ma
Neurosurgery, Binzhou Medical University Affiliated Hospital, 661Huanghe second Road, Binzhou, Shandong Province 256600, China.
Wenhu
W
Xu
Neurosurgery, Binzhou Medical University Affiliated Hospital, 661Huanghe second Road, Binzhou, Shandong Province 256600, China.
Meng
M
Li
Neurosurgery, Binzhou Medical University Affiliated Hospital, 661Huanghe second Road, Binzhou, Shandong Province 256600, China.
Jianmin
J
Li
Neurosurgery, Binzhou Medical University Affiliated Hospital, 661Huanghe second Road, Binzhou, Shandong Province 256600, China.
Wensheng
W
Zhang
Neurosurgery, Binzhou Medical University Affiliated Hospital, 661Huanghe second Road, Binzhou, Shandong Province 256600, China.
Qikai
Q
Sun
Institute of Human Anatomy and Histology and Embryology, Otology & Neuroscience Center, Binzhou Medical University, 346 Guanhai Road, Laishan District, Shandong Province 264003, China.
Xiaojing
X
An
Neurosurgery, Binzhou Medical University Affiliated Hospital, 661Huanghe second Road, Binzhou, Shandong Province 256600, China. Electronic address: lizefu163@163.com.
Zefu
Z
Li
D000236:Adenoma / Q000276:immunology / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001921:Brain / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D010911:Pituitary Neoplasms / Q000276:immunology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D019139:Tumor Escape
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; D016328:NF-kappa B; D012333:RNA, Messenger; D020780:Matrix Metalloproteinase 9
MICA; MMP-9; NF-κB; Nonfunctional pituitary adenomas; Prolactinoma pituitary adenomas; p-NF-κB; sMICA