Serologic evaluation of celiac disease in patients with beta thalassemia major and control.
OBJECTIVE
This study reports evaluated prevalence of CD in patients with Beta-thalassemia major.


BACKGROUND
Celiac Disease (CD) is an autoimmune disorder triggered by ingestion of gluten in genetically predisposed individuals.


METHODS
In this case-control study in a period of 3 years, which was performed on 620 children in two groups of Beta-thalassemia major patients (n=200) and control (n=420), serum tissue transglutamianse (tTG) IgA levels were measured. The two groups were compared together in terms of tTG IgA levels, and p<0.05 was considered significant.


RESULTS
The means of serum tTG IgA levels in patients with Beta-thalassemia major and control groups were 28.81±68.44 and 6.94±6.68 U/mL, respectively. There was a significant difference in favor of the case group (p=0.000). Body mass index in the two case and control groups had a significant difference (t=3.859, p=0.001). Belonging to each group will change the probability of having less than 20 in tTG IgA (odds=0.285) and it means that belonging to the control group has a protective role. There is only a significant association in the case of all population (r=0.102, p=0.011). Body mass index in the two case and control groups had a significant difference (t=3.859, p=0.001).


CONCLUSIONS
Probability of CD should be considered since the prevalence of CD is high in patients with and Beta-thalassemia major. Patients with thalassemia major are recommended for screening for CD.
Department of Pediatric, Zabol University of Medical Sciences, Zahedan, Iran.
Iraj
I
Shahramian
Department of Pediatric Gastroentrology, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Mohsen
SM
Dehghani
Department of Pediatric Gastroentrology, Shiraz University of Medical Sciences, Shiraz, Iran.
Mahmood
M
Haghighat
Children and Adolescents Health Research Center, Zahedan Medical University, Zahedan, Iran.
Noor Mohammad
NM
Noori
Children and Adolescents Health Research Center, Zahedan Medical University, Zahedan, Iran.
Ali Reza
AR
Teimouri
Children and Adolescents Health Research Center, Zahedan Medical University, Zahedan, Iran.
Elham
E
Sharafi
Children and Adolescents Health Research Center, Zahedan Medical University, Zahedan, Iran.
Manijeh
M
Kalili
Beta-thalassemia major; Celiac disease; Disease risk; Growth disorder; HLA