Changes in frequency of delayed graft function in deceased donor renal transplant recipient in a tertiary care center in Mexico.
BACKGROUND
Delayed graft function (DGF) is defined as the need for dialysis within the first seven days of transplantation. The frequency of DGF has decreased in the last five years compared with the previous 20 years of the kidney transplant program at a Mexican referral hospital.


OBJECTIVE
To determine the incidence and risk factors for DGF in the past five years (2009-2013).


METHODS
We analyzed a retrospective cohort of renal transplant recipients from deceased donors at our hospital between March 2009 and May 2013 (Period 2), and compared the results with a previously evaluated cohort (Period 1, between January 1990 and February 2009).


RESULTS
During the analyzed period, 78 deceased donor transplants were performed. The frequency of DGF was 9%. Multivariate analysis showed that recipient older age (OR: 1.074419; 95% CI: 1.0009-1.155116; p = 0.05), transoperative amines administration (OR: 7.73; 95% CI: 1.037-57.6; p = 0.046), and hypotension during surgery in the recipient (OR: 11.6; 95% CI: 1.33-100.8; p = 0.026) were risk factors for DGF.


CONCLUSIONS
The incidence of DGF has significantly decreased in the past five years when compared to the previous 20 years in our hospital.
Department of Transplants, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
Ana Lorena
AL
Noriega-Salas
Department of Transplants, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
Josefina
J
Alberú
Department of Transplants, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
Aczel I
AI
Sánchez-Cedillo
Department of Transplants, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
Luis
L
Navarro-Vargas
Department of Transplants, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
Víctor
V
Visag
Department of Transplants, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
Agustín
A
Vintimilla-Moscoso
Department of Transplants, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
José Luis
JL
López-Jiménez
Department of Transplants, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
José
J
Madrigal-Bustamante
Department of Transplants, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
Alan G
AG
Contreras
Department of Transplants, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
Mario
M
Vilatobá-Chapa
D000328:Adult; D000367:Age Factors; D000588:Amines / Q000008:administration & dosage*; D015331:Cohort Studies; D051799:Delayed Graft Function / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000453:epidemiology*; D015994:Incidence; D016030:Kidney Transplantation; D008297:Male; D008800:Mexico; D008875:Middle Aged; D015999:Multivariate Analysis; D006435:Renal Dialysis; D012189:Retrospective Studies; D012307:Risk Factors; D062606:Tertiary Care Centers
D000588:Amines