Transdermal fentanyl and its use in ovine surgery.
Fentanyl delivered via a transdermal patch has the potential to decrease the need for post-operative handling of sheep undergoing surgical procedures. Two studies were performed to test: (1) the ideal timing for the application of pre-emptive analgesic patches and (2) the efficacy of a 2 µg/kg/h dose, as extrapolated from other species. The first study had sheep divided into two groups. Group 1 had a fentanyl patch applied for 24 h prior to a patch change and group 2 had a fentanyl patch applied 72 h prior to a change. The second study applied the results obtained in the first and tested the efficacy of 2 µg/kg/h as an effective dose in an orthopaedic surgical environment. Results indicated that the ideal time for pre-emptive fentanyl patch administration is 24-36 h prior to surgery and that 2 µg/kg/h is an effective minimum therapeutic dose rate for the use of fentanyl as an analgesic in an orthopaedic surgical environment.
Surgical and Orthopaedic Research Laboratory, Prince of Wales Clinical School, University of New South Wales, Level 1 Clinical Sciences Building Avoca St, Randwick 2031 Australia. Electronic address: c.christou@unsw.edu.au.
Chris
C
Christou
Surgical and Orthopaedic Research Laboratory, Prince of Wales Clinical School, University of New South Wales, Level 1 Clinical Sciences Building Avoca St, Randwick 2031 Australia.
Rema A
RA
Oliver
Surgical and Orthopaedic Research Laboratory, Prince of Wales Clinical School, University of New South Wales, Level 1 Clinical Sciences Building Avoca St, Randwick 2031 Australia.
John
J
Rawlinson
Surgical and Orthopaedic Research Laboratory, Prince of Wales Clinical School, University of New South Wales, Level 1 Clinical Sciences Building Avoca St, Randwick 2031 Australia.
William R
WR
Walsh
D000698:Analgesia / Q000662:veterinary*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology*; D012756:Sheep / Q000601:surgery*; D057968:Transdermal Patch / Q000662:veterinary*
D000701:Analgesics, Opioid; D005283:Fentanyl
Analgesia; Fentanyl; Ovine; Pre-emptive; Sheep