Effects of free leucine supplementation and resistance training on muscle strength and functional status in older adults: a randomized controlled trial.
OBJECTIVE
To assess the effect of free leucine supplementation combined with resistance training versus resistance training only on muscle strength and functional status in older adults.


METHODS
This was a randomized, double-blind, placebo-controlled, parallel study with two intervention groups. Thirty older adults were randomly assigned to receive either 10 g leucine/day (leucine group [LG], n=15) or a placebo (control group [CG], n=15), plus resistance training over a 12-week period. Maximal overcoming isometric leg strength, functional status, nutritional status, body composition, health-related quality of life, depression, and dietary intake were assessed at 4 and 12 weeks. Missing data at 12 weeks were handled using mixed models for repeated measurements for data imputation.


RESULTS
Twenty-four subjects completed the 4-week assessment and eleven completed the 12-week intervention. Clinically significant gains were found in isometric leg strength at both assessment time points. Analysis of the effect size also showed how participants in LG outperformed those in CG for chair stands and the timed up and go test. No significant changes were observed for the rest of the outcomes.


CONCLUSIONS
Our combined analysis showed moderate changes in isometric leg muscle strength and certain components of functional status. The magnitude of changes found on these outcomes should be qualified as a positive effect of the concomitant intervention.
Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain.
Joan
J
Trabal
Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain.
Maria
M
Forga
Department of Endocrinology and Nutrition, Hospital Clínic Universitari de Barcelona, Barcelona, Catalonia, Spain.
Pere
P
Leyes
Biostatistics and Data Management Core Facility, IDIBAPS, Hospital Clinic Universitari de Barcelona, Barcelona, Catalonia, Spain ; Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.
Ferran
F
Torres
Residencia Ballesol Almogavers, Grupo Ballesol, Barcelona, Catalonia, Spain.
Jordi
J
Rubio
Centre de Rehabilitacio, Fundació Amiba, Badalona, Catalonia, Spain.
Esther
E
Prieto
Department of Nutrition and Food Science, Faculty of Pharmacy, Universitat de Barcelona, Barcelona, Catalonia, Spain.
Andreu
A
Farran-Codina
D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition; D003863:Depression / Q000453:epidemiology; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006304:Health Status; D006801:Humans; D007930:Leucine / Q000008:administration & dosage*; D008297:Male; D053580:Muscle Strength; D009752:Nutritional Status; D011788:Quality of Life; D055070:Resistance Training / Q000379:methods*
D007930:Leucine
aged; amino acid; elderly; functionality; strength training