Immunotherapy of metastatic and autochthonous liver cancer with IL-15/IL-15Rα fusion protein.
Liver cancer has a poor prognosis. Our recent study demonstrates that hyper-IL-15, composed of IL-15 and the sushi domain of IL-15 receptor α chain, provides an effective therapy against well-established metastatic and autochthonous liver cancers in mouse models by triggering activation and expansion of hepatic CD8+T cells.
Key Laboratory of Infection and Immunity; Institute of Biophysics; Chinese Academy of Sciences ; Beijing China ; Lineberger Comprehensive Cancer Center; School of Medicine; The University of North Carolina at Chapel Hill ; Chapel Hill, NC USA.
Liang
L
Cheng
Key Laboratory of Infection and Immunity; Institute of Biophysics; Chinese Academy of Sciences ; Beijing China ; University of Chinese Academy of Sciences ; Beijing China.
Xuexiang
X
Du
Key Laboratory of Infection and Immunity; Institute of Biophysics; Chinese Academy of Sciences ; Beijing China ; Lineberger Comprehensive Cancer Center; School of Medicine; The University of North Carolina at Chapel Hill ; Chapel Hill, NC USA.
Lishan
L
Su
Key Laboratory of Infection and Immunity; Institute of Biophysics; Chinese Academy of Sciences ; Beijing China.
Shengdian
S
Wang
CD8+ T cell; IFNγ; hyper-IL-15; immunotherapy; liver cancer