[Effects of modified Ganmai Dazao decoction on neuroendocrine system in patients with climacteric depression].
Clinical study of modified Ganmai Dazao decoction in the treatment of yang deficiency climacteric depression and observe the effects of modified Ganmai Dazao decoction on neuroendocrine system in patients with yang deficiency climacteric depression. 86 cases were randomly divided into treatment group treated with modified Ganmai Dazao decoction and control group treated with Deanxit. The curative effect was evaluated with Hamilton's depressive scale (HAMD) and pittsburgh sleep quality scale (PSQI) before and at the end of the two and four weeks of the treatment, the serum levels of serotonin (5-HT), norepinephrine (NE), estradiol (E2), follicle stimulating hormone (FSH), luteotropic hormone (LH) were detected before and after the four weeks of the treatment The results showed that the total effective power of treatment group was 88.4% and the total effective power of control group was 81.4% after four weeks interference, with insignificant difference between the two groups. After two and four weeks of the treatment, the score of HAMD decreased remarkably in both groups (P < 0.01), with insignificant difference between the two groups in same phase. After two and four weeks of the treatment, the total score of PSQI decreased remarkably in both groups (P < 0.05), with significant difference between the two groups after four weeks (P < 0.01). After four weeks of treatment, the serum levels of 5-HT and NE increased (P < 0.01), with insignificant difference between the groups. After four weeks of treatment, the serum levels of E2 increased obviously (P < 0.05), the levels of FSH decreased obviously (P < 0.05), the levels of LH decreased insignificant, with insignificant difference between two groups. This study indicates that modified Ganmai Dazao decoction has obvious therapeutic effects in the treatment of climacteric depression, and showed equivalent efficacy with Deanxit, and modified Ganmai Dazao decoction has better effect on improving the sleep quality in patients than Deanxit, the effect of improved clinical symptoms may be through adjusted levels of 5-HT, NE, E2, FSH and LH of climacteric depression.
Xiao-Juan
XJ
Ma
Jie
J
Zhao
Zhen-Yu
ZY
Feng
Jian-Min
JM
Chang
Shuang
S
Meng
Hu-Ze
HZ
Liu
Kai-Fang
KF
Fan
D000328:Adult; D003863:Depression / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008593:Menopause / Q000187:drug effects / Q000523:psychology*; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000378:metabolism; D009638:Norepinephrine / Q000097:blood; D008517:Phytotherapy; D012701:Serotonin / Q000097:blood
D004365:Drugs, Chinese Herbal; D012701:Serotonin; D005640:Follicle Stimulating Hormone; D009638:Norepinephrine