Molecularly imprinted polymers on a silica surface for the adsorption of tobacco-specific nitrosamines in mainstream cigarette smoke.
Tobacco-specific nitrosamines are one of the most important groups of carcinogens in tobacco products. Using adsorbents as filter additives is an effective way to reduce tobacco-specific nitrosamines in cigarette smoke. Molecularly imprinted polymers (MIPs) using nicotinamide as template were grafted on the silica gel surface to obtain MIP@SiO2 and employed as filter additives to absorb tobacco-specific nitrosamines in mainstream cigarette smoke. Four milligrams of MIP@SiO2 per cigarette was added to the interface between filter and tobacco rod to prepare a binary filter system. The mainstream smoke was collected on an industry-standard Cambridge filter pad and extracted with ammonium acetate aqueous solution before analysis. Compared to the cigarette smoke of the control group, the levels of tobacco-specific nitrosamines with silica gel and with MIP@SiO2 were both reduced, and the adsorption rates of N-nitrosonornicotine, N-nitrosoanabasine, N-nitrosoanatabine, and 4-(methylnitrosamino)-1-(3-pyridine)-1-butanone with silica gel and with MIP@SiO2 were 20.76, 15.32, 18.79, and 18.01%, and 41.33, 34.04, 37.86, and 35.53%, respectively. Furthermore the content of total particle materials in cigarette smoke with silica gel was decreased evidently but showed no observable change with MIP@SiO2 . It indicated MIP@SiO2 could selectively reduce tobacco-specific nitrosamines in the mainstream cigarette smoke with no change to the cigarette flavor.
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.|TCM-Integrated Hospital of Southern Medical University, Guangzhou, 510315, China.
Min-ting
MT
Li
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Yong-yan
YY
Zhu
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Li
L
Li
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Wen-na
WN
Wang
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Yong-guan
YG
Yin
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China.
Quan-hong
QH
Zhu
D000327:Adsorption; D002273:Carcinogens / Q000032:analysis; D013058:Mass Spectrometry; D008855:Microscopy, Electron, Scanning; D009602:Nitrosamines / Q000032:analysis / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D012822:Silicon Dioxide / Q000737:chemistry*; D012906:Smoke / Q000032:analysis*; D012907:Smoking; D017550:Spectroscopy, Fourier Transform Infrared; D062789:Tobacco Products
D002273:Carcinogens; D009602:Nitrosamines; D011108:Polymers; D012906:Smoke; C010257:N'-nitrosoanabasine; D012822:Silicon Dioxide; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; C032978:N'-nitrosoanatabine; C008655:N'-nitrosonornicotine
Cigarette smoke; Filter additives; Molecularly imprinted polymers; Tobacco-specific nitrosamines