Prevalence of HLA-B*57:01 allele in Argentinean HIV-1 infected patients.
Hypersensitivity reaction to abacavir (ABC hypersensitivity syndrome, AHS) is strongly associated with the presence of the HLA-B*57:01 allele. This study was designed to estimate the prevalence of HLA-B*57:01 allele in Argentinean HIV-1 infected patients. We analyzed the presence of HLA-B*57:01 allele in 1646 HIV-1 infected patients from different regions of Argentina. This allele was detected in 81 patients; most of them corresponded to patients living in the central region of the country. The prevalence of HLA-B*57:01 was 4.9%, similar to other Caucasian populations and higher than other data reported for South American populations. This strongly supports screening for the presence of HLA-B*57:01 in abacavir treatment of HIV-1 in our country.
Laboratorio de Biología Celular y Retrovirus-CONICET, Hospital de Pediatría 'Prof. Dr Juan P. Garrahan', Buenos Aires, Argentina.
M
M
Moragas
Instituto de Ciencias Básicas y Medicina Experimental, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
W H
WH
Belloso
Centro de Diagnóstico Médico de Alta Complejidad S.A. CIBIC, Santa Fe, Argentina.
M S
MS
Baquedano
Unidad Genómica, Stamboulian Laboratorio, Buenos Aires, Argentina.
M I
MI
Gutierrez
Dirección de SIDA y ETS, Ministerio de Salud de la Nación, Buenos Aires, Argentina.
E
E
Bissio
Instituto de Ciencias Básicas y Medicina Experimental, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
J M
JM
Larriba
Centro de Diagnóstico Médico de Alta Complejidad S.A. CIBIC, Santa Fe, Argentina.
F
F
Fay
Laboratorio de Biología Celular y Retrovirus-CONICET, Hospital de Pediatría 'Prof. Dr Juan P. Garrahan', Buenos Aires, Argentina.
P
P
Aulicino
Laboratorio de Biología Celular y Retrovirus-CONICET, Hospital de Pediatría 'Prof. Dr Juan P. Garrahan', Buenos Aires, Argentina.
J M
JM
Gurevich
Unidad Genómica, Stamboulian Laboratorio, Buenos Aires, Argentina.
M F
MF
Yaunguzian
Unidad Genómica, Stamboulian Laboratorio, Buenos Aires, Argentina.
A C
AC
Maldonado
Dirección de SIDA y ETS, Ministerio de Salud de la Nación, Buenos Aires, Argentina.
C
C
Falistocco
Laboratorio de Biología Celular y Retrovirus-CONICET, Hospital de Pediatría 'Prof. Dr Juan P. Garrahan', Buenos Aires, Argentina.
L
L
Sen
Laboratorio de Biología Celular y Retrovirus-CONICET, Hospital de Pediatría 'Prof. Dr Juan P. Garrahan', Buenos Aires, Argentina.
A
A
Mangano
D000328:Adult; D000483:Alleles; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001118:Argentina; D015224:Dideoxynucleosides / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D005260:Female; D015870:Gene Expression; D005787:Gene Frequency; D005820:Genetic Testing; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D000099227:Abacavir
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D000099227:Abacavir; C484830:HLA-B*57:01 antigen
HIV-1; HLA-B*57:01 genotyping; abacavir; frequency; hypersensitivity; pharmacogenetics