Pancreatic retransplantation is associated with poor allograft survival: an update of the United Network for Organ Sharing database.
The aim of the study was to assess outcomes of pancreas retransplantation versus primary pancreas transplantation.


METHODS
Data from the United Network for Organ Sharing database on all adult (age, ≥18 years) subjects who received pancreas and kidney-pancreas transplants between 1996 and 2012 were analyzed (n = 20,854). The subjects were analyzed in the following 2 groups: retransplant (n = 1149) and primary transplant (n = 19,705).


RESULTS
Kaplan-Meier analysis demonstrated significantly different patient survival (P < 0.0001) and death-censored graft survival (P < 0.0001) between the primary transplant versus retransplant subjects. Allograft survival was significantly poorer in the retransplantation group. Patient survival was greater in the retransplant group.


CONCLUSIONS
The results of our study differ from previous studies, which showed similar allograft survival in primary and secondary pancreas transplants. Further studies may elucidate specific patients who will benefit from retransplantation. At the present time, it would appear that pancreas retransplantation is associated with poor graft survival and that retransplantation should not be considered for all patients with primary pancreatic allograft failure.
From the Department of Transplantation, North Shore Long Island Jewish Health System-Hofstra University School of Medicine, Manhasset, NY.
Eric
E
Siskind
Caroline
C
Maloney
Vivek
V
Jayaschandaran
Adam
A
Kressel
Meredith
M
Akerman
Adam
A
Shen
Leo
L
Amodu
John
J
Platz
John P
JP
Ricci
Madhu
M
Bhaskaran
Amit
A
Basu
Ernesto
E
Molmenti
Jorge
J
Ortiz
D000293:Adolescent; D000328:Adult; D064591:Allografts; D016208:Databases, Factual; D005260:Female; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D016035:Pancreas Transplantation / Q000009:adverse effects / Q000379:methods*; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods*; D012086:Reoperation; D012307:Risk Factors; D013997:Time Factors; D009927:Tissue and Organ Procurement; D014481:United States; D055815:Young Adult