[Design and synthesis of photoaffinity biotin labelled 2'-O-propargyl-guanosine].
Photoaffinity labeling is widely applied to demonstrate targets of small molecule ligands. In this paper, biotin photoaffinity labeled molecule with propargyl group 1 has been designed and synthesized, followed it's labeling of N2-acetyl-2'-O-propargyl guanosine 9 by "click chemistry". This technology presents delight development potential in labeling of second messenger cyclic nucleotide, antisense oligonucleotide or siRNA.
Lu-xin
LX
Na
Xin
X
Liu
Zhuo-ming
ZM
Meng
Zhu
Z
Guan
Li-he
LH
Zhang
Zhen-jun
ZJ
Yang
D001710:Biotin / Q000737:chemistry; D057930:Click Chemistry; D006151:Guanosine / Q000138:chemical synthesis* / Q000737:chemistry*; D008024:Ligands; D019920:Photoaffinity Labels
D008024:Ligands; D019920:Photoaffinity Labels; D006151:Guanosine; D001710:Biotin