Iron-Mediated Control of Pseudomonas aeruginosa-Staphylococcus aureus Interactions in the Cystic Fibrosis Lung.
Communication is an important factor for bacterial survival, growth, and persistence. Much work has examined both inter- and intraspecies interactions and their effects on virulence. Now, researchers have begun to explore the ways in which host-modulated factors can impact bacterial interactions and subsequently affect patient outcomes. In this issue, two papers discuss how the host environment alters interactions between the pathogens Pseudomonas aeruginosa and Staphylococcus aureus, largely in the context of cystic fibrosis.
Department of Molecular Biosciences, Institute of Cellular and Molecular Biology, Center for Infectious Disease, The University of Texas at Austin, Austin, Texas, USA.
Patricia M
PM
Barnabie
Department of Molecular Biosciences, Institute of Cellular and Molecular Biology, Center for Infectious Disease, The University of Texas at Austin, Austin, Texas, USA mwhiteley@austin.utexas.edu.
Marvin
M
Whiteley
D000890:Anti-Infective Agents / Q000378:metabolism*; D001431:Bacteriological Techniques; D018920:Coculture Techniques; D003550:Cystic Fibrosis / Q000382:microbiology*; D006801:Humans; D007501:Iron / Q000494:pharmacology*; D050296:Microbial Viability; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism* / Q000502:physiology*; D013211:Staphylococcus aureus / Q000378:metabolism*
D000890:Anti-Infective Agents; D007501:Iron