[The choleretic and hepatoprotective effect of Hypecoum erectum extract].
The choleretic and hepatoprotective effect of Hypecoum erectum L. dry extract on toxic hepatitis was studied. Experimental hepatitis was caused by the introduction of D-galactosamine to Wistar white rats in the dose of 500 mg/kg of the animal weight once a day for 3 days. The H. erectum extract was administered per os in the dose of 50 mg/kg for 7 days. It has been established that H. erectum extract has a marked hepatoprotective effect in the case of D-galactosamine hepatitis in white rats that is characterized by inhibition of the disturbances in cholate-synthetic functions of the liver, increase of bile secretion rate, preservation of cholate concentration in the bile. The tested remedy diminishes dystrophic and necrotic processes, decreases the intensity of inflammatory infiltration in the liver and stimulates regeneration of liver cells in D-galactosamine hepatitis.
S M
SM
Nikolaev
A V
AV
Fedorov
Ia G
IaG
Razuvaeva
Z G
ZG
Sambueva
A A
AA
Toropova
D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism; D001647:Bile Acids and Salts / Q000032:analysis; D001663:Bilirubin / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D002784:Cholesterol / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D028101:Papaveraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D017208:Rats, Wistar; D013997:Time Factors
D001647:Bile Acids and Salts; D002756:Cholagogues and Choleretics; D010936:Plant Extracts; D002784:Cholesterol; D001663:Bilirubin