Transcranial Direct Current Stimulation Ameliorates Behavioral Deficits and Reduces Oxidative Stress in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Mouse Model of Parkinson's Disease.
OBJECTIVE
Oxidative stress is involved in the pathological process of Parkinson's disease (PD). The present study was designed to investigate the effects of transcranial direct current stimulation (tDCS) on the oxidative stress in a mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).


METHODS
The animals were modulated by tDCS. Behavioral alterations were observed after three weeks of tDCS treatment using rotary performance tests. The mice were sacrificed for the measurement of the level of dopamine (DA), enzymatic tyrosine hydroxylase (TH), nonenzymatic malonaldehyde (MDA), an enzymatic superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) in the mouse brain and serum.


RESULTS
The mice treated with MPTP had an increased MDA level but a decreased SOD and GSH-Px activity, as well as a behavior impairment. These abnormalities were significantly attenuated by tDCS treatment and by levodopa and benserazide.


CONCLUSIONS
The study demonstrated that the tDCS could have a potential for the therapeutic usage in the PD.
The Laboratory of Neuronal Network and Brain Disease Modulation, Yangtze University Medical School, Jingzhou, Hubei, China.
Chengbiao
C
Lu
The Key Laboratory of Industrial Computer Control Engineering of Hebei Province, Institute of Electrical Engineering, Yanshan University, Qinhuangdao, Hebei, China.
Yun
Y
Wei
The Key Laboratory of Industrial Computer Control Engineering of Hebei Province, Institute of Electrical Engineering, Yanshan University, Qinhuangdao, Hebei, China.
Rui
R
Hu
The Key Laboratory of Industrial Computer Control Engineering of Hebei Province, Institute of Electrical Engineering, Yanshan University, Qinhuangdao, Hebei, China.
Yong
Y
Wang
The Key Laboratory of Industrial Computer Control Engineering of Hebei Province, Institute of Electrical Engineering, Yanshan University, Qinhuangdao, Hebei, China.
Kun
K
Li
State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.|Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.
Xiaoli
X
Li
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D001523:Mental Disorders / Q000139:chemically induced / Q000473:pathology / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000187:drug effects*; D010300:Parkinson Disease / Q000150:complications / Q000209:etiology*; D011597:Psychomotor Performance / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism; D065908:Transcranial Direct Current Stimulation / Q000379:methods*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D008315:Malondialdehyde; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D005979:Glutathione Peroxidase; D014446:Tyrosine 3-Monooxygenase; D013482:Superoxide Dismutase; D004298:Dopamine
Behavior; MPTP; Parkinson's disease; mouse; tDCS