[Hypertension].
Hypertension is the largest risk factor for cardiovascular disease (CVD), and the most common life-style related disease in Japan. Hypertension is, overall, a male-dominant disease, however its impact on CVD in female grows markedly after menopause. The alteration in estrogen/androgen balance causes endothelial dysfunction, obesity, sympathetic activation, renin-angiotensin-aldosterone system activation, salt sensitivity and oxidative stress. These mechanisms enhance the elevation of systemic blood pressure and get caught in a vicious circle in female hypertension.
Naoyuki
N
Hasebe
D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D018384:Oxidative Stress; D017698:Postmenopause; D017410:Practice Guidelines as Topic; D012084:Renin-Angiotensin System; D012727:Sex Characteristics
D004967:Estrogens