The rs10885122 polymorphism of the adrenoceptor alpha 2A (ADRA2A) gene in Euro-Brazilians with type 2 diabetes mellitus.
OBJECTIVE
To investigate the association of the rs10885122G>T polymorphism in the ADRA2A gene in a Euro-Brazilian sample of healthy (controls) and type 2 diabetic (T2D) subjects.


METHODS
We used fluorescent probes (TaqMan) to genotype 241 subjects, that is, 121 healthy and 120 T2D subjects, who were classified based on the Brazilian Diabetes Association (2013) and American Diabetes Association (2014) criteria.


RESULTS
The genotype and allele frequencies showed no significant (P > 0.05) difference between the two studied groups. The minor allele (T) frequencies (95%CI) for rs10885122 were 19% (14-24%) and 20% (15-26%) for healthy and T2D groups, respectively. Carriers of the T allele (genotypes GT+TT) were significantly associated (P = 0.016) with approximately a 7-kg body weight reduction compared with the genotype GG, which was only found in the T2D group.


CONCLUSIONS
The rs10885122G>T polymorphism of the ADRA2A gene was not associated with T2D in Euro-Brazilians, and carriers of the T allele had lower body weight in the presence of T2D.
Federal University of Parana, Curitiba, PR, Brazil.
Marciane
M
Welter
Federal University of Parana, Curitiba, PR, Brazil.
Henrique Ravanhol
HR
Frigeri
Hospital, UFPR, Curitiba, PR, Brazil.
Rosângela Roginski
RR
Réa
Department of Biochemistry and Molecular Biology, UFPR, Curitiba, PR, Brazil.
Emanuel Maltempi
EM
de Souza
Federal University of Parana, Curitiba, PR, Brazil.
Dayane
D
Alberton
Federal University of Parana, Curitiba, PR, Brazil.
Geraldo
G
Picheth
Federal University of Parana, Curitiba, PR, Brazil.
Fabiane Gomes de Moraes
FG
Rego
D000328:Adult; D000368:Aged; D001938:Brazil; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D044465:White People / Q000208:ethnology / Q000235:genetics*
C547768:ADRA2A protein, human; D018341:Receptors, Adrenergic, alpha-2