Isolation of β-indomycinone guided by cytotoxicity tests from Streptomyces sp. IFM11607 and revision of its double bond geometry.
The antibiotic β-indomycinone was isolated from Streptomyces sp. IFM11607 by cytotoxicity-guided fractionation against human gastric adenocarcinoma AGS cells, and the geometry of its δ17,18-double bond was revised from E to Z based on the coupling constant.
Kentaro
K
Tsukahara
Kazufumi
K
Toume
Hanako
H
Ito
Naoki
N
Ishikawa
Masami
M
Ishibashi
D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
D000880:Anthraquinones; D000970:Antineoplastic Agents