Balanced hydroxyethyl starch solution and hyperglycaemia in non diabetics - a prospective, randomized and controlled study.
BACKGROUND
There are very few studies that have examined the effect of hydroxyethyl starch (HES) solutions on blood glucose level. The study was aimed to compare the effects on blood glucose levels in patients undergoing lower limb surgeries under neuraxial block, receiving HES with those receiving 0.9% saline.


METHODS
160 non-diabetic ASA I or II patients, aged between 18-65 years were selected for the trial. Patients were divided into two groups; Group C (n = 80, patients received only 0.9% saline for preloading and maintenance until six hours of the end of preloading) and Group T (n = 80, patients received Tetraspan™ 10 mL kg⁻¹, for preloading and 0.9% saline for maintenance until six hours from the end of preloading). Blood glucose was recorded prior to the start of preloading and repeated at two, four and six hours after the end of HES infusion or the preloading dose of 0.9% saline.


RESULTS
The following blood glucose levels were comparable at all times; fasting/baseline (85.3 ± 19.2 mg dL⁻¹ in group C and 95.4 ± 17.3 mg dL⁻¹ in group T); increase in blood glucose concentration at 2 hours (6.44 ± 20.59 mg dL⁻¹ in group C and 10.8 ± 18.1 mg dL⁻¹ in group T); 4 hours (4.1 ± 12.1 mg dL⁻¹ in group C and 3.5 ± 11.8 mg dL⁻¹ in group T); and at 6 hours (2.9 ± 13.4 mg dL⁻¹ in group C and 3.5 ± 10.6 mg dL⁻¹ in group T).


CONCLUSIONS
A balanced HES solution administered intravenously did not cause an increase in blood glucose concentrations compared to those who received 0.9% saline.
Department of Anaesthesiology, Sahara Hospital, Viraj Khand, Gomtinagar, Lucknow, India. soumynath2185@gmail.com.
Soumya Sankar
SS
Nath
Sundeep T
ST
Pawar
Farrukh
F
Ansari
Roy
R
Debashis
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000009:adverse effects*; D006943:Hyperglycemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000009:adverse effects*; D011446:Prospective Studies; D012996:Solutions
D001786:Blood Glucose; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D012996:Solutions