Quality of Life After Living Donor Hepatectomy for Liver Transplantation.
BACKGROUND
Living donor liver transplantation (LDLT) involves healthy individuals undergoing voluntary major hepatic resection. LDLT program only started in 2012 in Pakistan and its impact on donor's quality of life (QOL) post resection is not known. The objective of this study was to determine health-related QOL in donors who underwent hepatectomy in country's first liver transplant program.


METHODS
A total of 60 donors who underwent hepatectomy between 2012 and 2014 with a minimum follow-up of 6 months were included in the study. Short form (SF-36) and Profile of mood states (POMS-65) was used to assess QOL. In addition scores were compared between patients who did and did not develop complications.


RESULTS
Mean time duration between hepatectomy and administration of questionnaire was 15 ± 5.1 months. Median age was 28 (19-45) years. Mean BMI was 24.4 ± 3.7. A total of 7 (11.6%) Grade 3 and above complications were observed in donors. Donors exceeded a score of 90 in 6 out of 8 evaluated categories on SF-36. The highest mean score was recorded for emotional role limitation 95.5 ± 17.1 and lowest for energy 84.8 ± 17.5. The mean score for anger was 6.6 ± 7.5. Donors also did well on the POMS vigor score with a mean of 22.7 ± 5. No significant difference in scores was observed between donors with and without complications for any of the categories except tension. Donors who developed complications post-operatively had a significantly low mean tension score of 1.5 versus 3.8 for donors without complications.


CONCLUSIONS
Acceptable post donation QOL was achieved and surgical complications did not adversely affect SF-36 and POMS scores.
Department of HPB and Liver Transplantation, Shifa International Hospital, Islamabad, Pakistan, abubakar.hafeez@yahoo.com.
Abu Bakar Hafeez
AB
Bhatti
Haseeb
H
Zia
Faisal Saud
FS
Dar
Mariam Qasim
MQ
Zia
Amara
A
Nasir
Farah
F
Saif
Abdul
A
WahabYousafzai
Farah
F
Imtiaz
Mohammad
M
Salih
Najmul Hassan
NH
Shah
D000328:Adult; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000534:rehabilitation*; D006801:Humans; D016031:Liver Transplantation; D019520:Living Donors / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D011594:Psychometrics; D011788:Quality of Life; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D020858:Tissue and Organ Harvesting / Q000009:adverse effects / Q000534:rehabilitation*; D055815:Young Adult