Dendritic Cell-Based Cancer Immunotherapy against Multiple Myeloma: From Bench to Clinic.
Although the introduction of stem cell transplantation and novel agents has improved survival, multiple myeloma (MM) is still difficult to cure. Alternative approaches are clearly needed to prolong the survival of patients with MM. Dendritic cell (DC) therapy is a very promising tool immunologically in MM. We developed a method to generate potent DCs with increased Th1 polarization and migration ability for inducing strong myeloma-specific cytotoxic T lymphocytes. In this review, we discuss how the efficacy of cancer immunotherapy using DCs can be improved in MM.
Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Hwasun, Korea.
My-Dung
MD
Hoang
Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Hwasun, Korea. ; Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Sung-Hoon
SH
Jung
Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Hyun-Ju
HJ
Lee
Vaxcell-Bio Therapeutics, Hwasun, Korea.
Youn-Kyung
YK
Lee
Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Thanh-Nhan
TN
Nguyen-Pham
Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Nu-Ri
NR
Choi
Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Manh-Cuong
MC
Vo
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Seung-Shin
SS
Lee
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Jae-Sook
JS
Ahn
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Deok-Hwan
DH
Yang
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Yeo-Kyeoung
YK
Kim
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
Hyeoung-Joon
HJ
Kim
Research Center for Cancer Immunotherapy, Chonnam National University Hwasun Hospital, Hwasun, Korea. ; Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea. ; Vaxcell-Bio Therapeutics, Hwasun, Korea.
Je-Jung
JJ
Lee
Dendritic cells; Immunotherapy; Multiple myeloma