Stereoselective synthesis of glycosides using (salen)Co catalysts as promoters.
The use of (salen)Co catalysts as a new class of bench-stable stereoselective glycosylation promoters of trichloroacetimidate glycosyl donors at room temperature is described. The conditions are practical and do not require the use of molecular sieves with products being isolated in good to high yields.
School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK. m.c.galan@bris.ac.uk.
Sandra
S
Medina
Alexander S
AS
Henderson
John F
JF
Bower
M Carmen
MC
Galan
D000081:Acetamides / Q000737:chemistry; D002384:Catalysis; D062845:Chloroacetates / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry*; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D013237:Stereoisomerism; D013696:Temperature
D000081:Acetamides; D062845:Chloroacetates; D005029:Ethylenediamines; D006027:Glycosides; D003035:Cobalt; C011452:disalicylaldehyde ethylenediamine; C009528:trichloroacetamide