Early-phase differences in health-related quality of life, psychological status, and physical function between human leucocyte antigen-haploidentical and other allogeneic haematopoietic stem cell transplantation recipients.
OBJECTIVE
This study investigated the differences between allogeneic haematopoietic stem cell transplantation (allo-HSCT) patients receiving HSC from human leucocyte antigen (HLA)-haploidentical donors (HID) and other donors that included HLA-matched sibling, matched unrelated, and unrelated umbilical cord blood donors in the 6 weeks after HSCT with respect to quality of life (QOL), psychological status, and physical function.


METHODS
The study included 126 patients (HID group, n = 100; other donor group, n = 26) who underwent allo-HSCT between July 2007 and December 2012. Patients were evaluated for health-related QOL using the Medical Outcome Study 36-item Short Form Health Survey. Psychological status was measured by Hospital Anxiety and Depression Scale. Physical function was assessed using tests for handgrip strength, knee extensor strength, and the 6-min walk test.


RESULTS
After HSCT, the HID group showed significantly greater improvements in the general health subscale and Mental Component Summary (MCS) of QOL than the other donor group (P < 0.01). Multivariate analysis confirmed that complete remission and age were associated with changes in the general health subscale before and after HSCT (P < 0.05). With regard to physical function, the HID group showed significantly more decline than the other donor group with respect to handgrip strength and knee extensor muscle strength after HSCT (P < 0.05). Total corticosteroid dose was associated with decreased handgrip strength before and after HSCT (P < 0.05).


CONCLUSIONS
The donor type affects QOL, psychological status, and physical function in allo-HSCT recipients; these findings may provide insights for customised rehabilitation strategies for HSCT recipients.
Department of Rehabilitation, Hyogo College of Medicine Hospital, Nishinomiya, Japan. Electronic address: ptmorishin@yahoo.co.jp.
Shinichiro
S
Morishita
Division of Haematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address: kaidak@hyo-med.ac.jp.
Katsuji
K
Kaida
Department of Rehabilitation, Hyogo College of Medicine Hospital, Nishinomiya, Japan. Electronic address: yamashin5577@yahoo.co.jp.
Shinya
S
Yamauchi
Department of Rehabilitation, Hyogo College of Medicine Hospital, Nishinomiya, Japan. Electronic address: waka.t2s920@gmail.com.
Tatsushi
T
Wakasugi
Division of Haematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address: kame@hyo-med.ac.jp.
Kazuhiro
K
Ikegame
Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address: norihiko@hyo-med.ac.jp.
Norihiko
N
Kodama
Division of Haematology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address: ogawah@hyo-med.ac.jp.
Hiroyasu
H
Ogawa
Department of Rehabilitation Medicine, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address: domen@aqu.bekkoame.ne.jp.
Kazuhisa
K
Domen
D000328:Adult; D000704:Analysis of Variance; D016208:Databases, Factual; D005260:Female; D006084:Graft Rejection; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods* / Q000523:psychology*; D006648:Histocompatibility / Q000276:immunology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D012044:Regression Analysis; D018570:Risk Assessment; D013312:Stress, Physiological; D013315:Stress, Psychological; D014019:Tissue Donors / Q000523:psychology*; D066027:Transplant Recipients / Q000523:psychology*; D014184:Transplantation, Homologous / Q000379:methods / Q000523:psychology; D016896:Treatment Outcome
D006680:HLA Antigens
Allogeneic haematopoietic stem cell transplantation; HLA-haploidentical donor; Health-related QOL; Oncology; Physical function; Psychological status