Rifampicin-dependent antibodies target glycoprotein IIb/IIIa and cause clearance of human platelets in NOD/SCID mice.
Department of Haematology, the First Affiliated Hospital of Liaoning Medical University, Jinzhou, China.
Ping
P
Sun
Department of Haematology, First Affiliated Hospital, Medical College of Shihezi University, Shihezi, China.
Guangsheng
G
Wu
Institution of Haematology Research, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Rui-lan
RL
Gao
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Liaoning Medical University, Jinzhou, China.
Shengyi
S
Liu
School of Medical Sciences (Physiology) and Bosch Institute, Anderson Stuart Bldg (F13), University of Sydney, Sydney, NSW, Australia.
William D
WD
Phillips
Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Liaoning Medical University, Jinzhou, China. simonl308@hotmail.com.
Simon X
SX
Liang
D000818:Animals; D001792:Blood Platelets / Q000276:immunology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*; D012293:Rifampin / Q000276:immunology*
D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D012293:Rifampin; D008775:Methylprednisolone
drug-induced; glycoprotein IIb/IIIa; non-obese diabetic severe combined immunodeficient mouse model; rifampicin-dependent; thrombocytopenia