Oral administration of apple condensed tannins delays rheumatoid arthritis development in mice via downregulation of T helper 17 (Th17) cell responses.
Apples are known to contain high concentrations of phenolic compounds such as condensed tannins. Consumption of condensed tannins has been reported to reduce the risk of many types of chronic diseases including allergies. However, their therapeutic effectiveness and potential in treating autoimmune disease remain controversial. Here, the effect of oral administration of apple condensed tannins (ACT) prepared from apples (Malus pumila cv. Fuji) on bovine type II collagen (CII)-induced arthritis in DBA1/J mice, a well-established murine model of human rheumatoid arthritis (RA), was evaluated. As compared to the control (without ACT administration) group, RA development was delayed and a significant reduction in the RA clinical score was observed in the ACT-administered group. Using cultured splenocytes isolated from CII-immunized mice, ACT-administration was shown to decrease the CII-induced increases in IL-17 expression and production in vitro. We propose that downregulation of T helper (Th) 17 cells is responsible for the ACT-induced RA suppression.
National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.
Kosuke
K
Nakamura
National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.
Hideki
H
Matsuoka
Asahi Group Holdings, Ltd, Moriya, Ibaraki, Japan.
Syohei
S
Nakashima
Asahi Group Holdings, Ltd, Moriya, Ibaraki, Japan.
Tomomasa
T
Kanda
National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.
Tomoko
T
Nishimaki-Mogami
National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan.
Hiroshi
H
Akiyama
D000284:Administration, Oral; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000517:prevention & control*; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism; D027845:Malus / Q000737:chemistry*; D008811:Mice, Inbred DBA; D044945:Proanthocyanidins / Q000008:administration & dosage / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology; D058504:Th17 Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
D016207:Cytokines; D020381:Interleukin-17; D044945:Proanthocyanidins
Apple condensed tannins; Oral administration; Phytochemical; Rheumatoid arthritis; T helper