The association between three promoter polymorphisms of IL-1 and stroke: a meta-analysis.
OBJECTIVE
The association between Interleukin-1 (IL-1) gene polymorphism and stroke remains controversial. The present study was designed to clarify this relationship through a pooled analysis of the numerous epidemiological studies focusing on this association.


METHODS
Published data addressing the association between polymorphism of the IL-1 gene and stroke were selected from electronic databases. A total of 21 studies from 19 publications including 5280 stroke patients and 5699 controls were included in this meta-analysis which detect whether IL-1α-889C/T, IL-1β-511C/T and IL-1 RN polymorphism were associated with stroke susceptibility.


RESULTS
The combined results of overall analysis revealed that there was a significant association between IL-1α-889C/T polymorphism and stroke (allele model: OR = 1.39, 95% CI = 1.14-1.68, P < 0.001; recessive model: OR = 1.56, 95% CI = 1.27-1.90, P < 0.001; dominant model: OR = 1.45, 95% CI = 1.13-1.87, P = 0.004; additive model: OR = 1.70, 95% CI = 1.37-2.10, P < 0.001). On a subgroup analysis by ethnicity of study population, significant association was found in Asians (allele model: OR = 1.25 95% CI = 1.12-1.39, P < 0.001; recessive model: OR = 1.36, 95% CI = 1.09-1.69, P = 0.007; dominant model: OR = 1.29, 95% CI = 1.12-1.48, P < 0.001; additive model: OR = 1.42, 95% CI = 1.13-1.80, P = 0.003). There are no associations of IL-1β-511C/T and IL-RN polymorphisms on stroke risk were identified.


CONCLUSIONS
In conclusion, our results suggested that IL-1α-889C/T polymorphism is associated with stroke risk, especially in Asians. However, no associations of IL-1β-511C/T and IL-RN polymorphisms on stroke risk in overall analysis or subgroup analysis.
Department of Radiology, The Second Hospital of Anhui Medical University, China. Electronic address: nike6621@sina.com.
Liwei
L
Zou
Department of Radiology, The Second Hospital of Anhui Medical University, China. Electronic address: 178331090@qq.com.
Hong
H
Zhao
Department of Radiology, The Second Hospital of Anhui Medical University, China. Electronic address: gxj0306@126.com.
Xijun
X
Gong
Department of Radiology, The Second Hospital of Anhui Medical University, China. Electronic address: 414197855@qq.com.
Anhong
A
Jiang
Department of Radiology, The Second Hospital of Anhui Medical University, China. Electronic address: 414197855@qq.com.
Song
S
Guan
Department of Radiology, The Second Hospital of Anhui Medical University, China. Electronic address: long9y8r@163.com.
Longsheng
L
Wang
Department of Radiology, The Second Hospital of Anhui Medical University, China. Electronic address: zhengss0509@sina.com.
Suisheng
S
Zheng
D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D020521:Stroke / Q000235:genetics
D007375:Interleukin-1
IL-1; Meta-analysis; Polymorphism; Stroke