Malignant Transformation of Pelvic Endometriosis: Case Series and Review of the Literature.
Endometriosis affects 4% to 13% of all women of reproductive age although its true incidence is unknown. The ability of endometriosis to transform into malignancy, first described by Sampson in 1925, is a rare occurrence affecting 1% of lesions with ovary being the primary site in 79%. The authors describe 3 premenopausal women without risk factors for malignancy presenting with ovarian and/or extraovarian endometrioid adenocarcinoma. All of them demonstrated features of pre-/coexisting endometriosis but malignancy was preoperatively suspected in only 1 instance. Postsurgical follow-up of the cases did not document any recurrence. The propensity for malignant conversion occurring in women 10 to 20 years younger vis-a-vis those affected by de novo ovarian cancer, destruction of the endometriotic foci, and underreporting vindicate close follow-up and scrutiny of women with endometriosis and ovarian endometriomas.
Fernandez Hospital, Hyderabad, India.
Sunil
S
Jaiman
Fernandez Hospital, Hyderabad, India.
Manjula
M
Pochiraju
Fernandez Hospital, Hyderabad, India drgsirisharao@gmail.com.
Sirisha Rao
SR
Gundabattula
Fernandez Hospital, Hyderabad, India.
Kameswari
K
Surampudi
Fernandez Hospital, Hyderabad, India.
Dama Venkata Lakshmi
DV
Narayana Rao
Fernandez Hospital, Hyderabad, India.
Sreekanth
S
Kandikattu
D000328:Adult; D018269:Carcinoma, Endometrioid / Q000473:pathology*; D004715:Endometriosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*
endometrioid adenocarcinoma; endometrioma; epithelial ovarian cancer; malignant transformation; pelvic endometriosis