Childhood-onset schizophrenia case with 2.2 Mb deletion at chromosome 3p12.2-p12.1 and two large chromosomal abnormalities at 16q22.3-q24.3 and Xq23-q28.
Childhood-onset schizophrenia is rare, comprising 1% of known schizophrenia cases. Here, we report a patient with childhood-onset schizophrenia who has three large chromosomal abnormalities: an inherited 2.2 Mb deletion of chromosome 3p12.2-p12.1, a de novo 16.7 Mb duplication of 16q22.3-24.3, and a de novo 43 Mb deletion of Xq23-q28.
Interdisciplinary Graduate Program in Genetics, University of Iowa Iowa City, Iowa ; Department of Psychiatry, University of Iowa Iowa City, Iowa.
Danielle
D
Rudd
Department of Psychiatry, University of Iowa Iowa City, Iowa.
Michael
M
Axelsen
Department of Psychiatry, University of Iowa Iowa City, Iowa.
Eric A
EA
Epping
Department of Psychiatry, University of Iowa Iowa City, Iowa.
Nancy
N
Andreasen
Department of Psychiatry, University of Iowa Iowa City, Iowa.
Thomas
T
Wassink
Childhood-onset schizophrenia; copy number variant; cytogenetic; partial monsomy X; partial trisomy 16