Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro.
This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/ using the strain Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm formation (95%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known for its resistance.
University of Belgrade, Institute for Multidisciplinary Research - IMSI, Department of Life Sciences, Belgrade, Serbia. borispejin@imsi.rs.
Boris
B
Pejin
Ana
A
Ciric
Jasmina D
JD
Markovic
Jasmina
J
Glamoclija
Milos
M
Nikolic
Bojana
B
Stanimirovic
Marina
M
Sokovic
D018441:Biofilms / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000502:physiology; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology*; D053038:Quorum Sensing / Q000187:drug effects
D011794:Quercetin