Acid-responsive nanospheres from an asparagine-derived amphiphile.
We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0-50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
Adelphe M
AM
Mfuh
Texas A&M University-San Antonio, One University Way, San Antonio, TX 78224, USA.
Mathew P D
MP
Mahindaratne
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
Audrey E
AE
Yñigez-Gutierrez
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
Juan R
JR
Ramos Dominguez
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
Jefferson T
JT
Bedell
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
Carlos D
CD
Garcia
Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA.
George R
GR
Negrete