Low volume-high intensity interval exercise elicits antioxidant and anti-inflammatory effects in humans.
The purpose of the present study was to compare acute changes in oxidative stress and inflammation in response to steady state and low volume, high intensity interval exercise (LV-HIIE). Untrained healthy males (n = 10, mean ± s: age 22 ± 3 years; VO2MAX 42.7 ± 5.0 ml · kg(-1) · min(-1)) undertook three exercise bouts: a bout of LV-HIIE (10 × 1 min 90% VO2MAX intervals) and two energy-matched steady-state cycling bouts at a moderate (60% VO2MAX; 27 min, MOD) and high (80% VO2MAX; 20 min, HIGH) intensity on separate days. Markers of oxidative stress, inflammation and physiological stress were assessed before, at the end of exercise and 30 min post-exercise (post+30). At the end of all exercise bouts, significant changes in lipid hydroperoxides (LOOH) and protein carbonyls (PCs) (LOOH (nM): MOD +0.36; HIGH +3.09; LV-HIIE +5.51 and PC (nmol · mg(-1) protein): MOD -0.24; HIGH -0.11; LV-HIIE -0.37) were observed. Total antioxidant capacity (TAC) increased post+30, relative to the end of all exercise bouts (TAC (µM): MOD +189; HIGH +135; LV-HIIE +102). Interleukin (IL)-6 and IL-10 increased post+30 in HIGH and LV-HIIE only (P < 0.05). HIGH caused the greatest lymphocytosis, adrenaline and cardiovascular response (P < 0.05). At a reduced energy cost and physiological stress, LV-HIIE elicited similar cytokine and oxidative stress responses to HIGH.
a School of Sport, Exercise & Rehabilitation Sciences , The University of Birmingham , Birmingham , UK.|b Institute of Science and the Environment , University of Worcester , Worcester , UK.
Alex J
AJ
Wadley
c Centre for Cardiovascular Science , University of Birmingham , Birmingham , UK.
Yu-Wen
YW
Chen
c Centre for Cardiovascular Science , University of Birmingham , Birmingham , UK.
Gregory Y H
GY
Lip
a School of Sport, Exercise & Rehabilitation Sciences , The University of Birmingham , Birmingham , UK.
James P
JP
Fisher
a School of Sport, Exercise & Rehabilitation Sciences , The University of Birmingham , Birmingham , UK.
Sarah
S
Aldred
D001794:Blood Pressure; D004734:Energy Metabolism; D004837:Epinephrine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D010806:Physical Education and Training / Q000379:methods*; D050050:Protein Carbonylation; D055815:Young Adult
D015850:Interleukin-6; D008054:Lipid Peroxides; D016753:Interleukin-10; D004837:Epinephrine
antioxidant; cytokine; lipid oxidation; protein oxidation; reactive oxygen species