Programmed death-ligand 1 (PD-L1) may play a role in malignant glioma infiltration.
Infiltration is the main cause of death of malignant glioma patients. However, the mechanisms of the infiltration in the development of brain cancer (glioblastoma multiforme) are not completely understood. Here, we hypothesized that, in the development of human brain cancer, infiltration is primarily due to differentiated cancer cells and that the cell surface molecule programmed death-ligand 1 (PD-L1) may play an important role in brain tumor infiltration. PD-L1 is highly expressed in differentiated glioma cells in comparison to undifferentiated ones. As PD-L1 has both pro-survival and immunoinhibitory functions in tumor cells, the potential role of PD-L1 in tumor propagation suggest a new therapeutic target for preventing glioma infiltration and recurrence.
Department of Neurosurgery, Shengjing Hospital, China Medical University, PR China. Electronic address: zhlei63@163.com.
Lei
L
Zhang
University of Wisconsin-Madison, United States.
Zhiqing
Z
Zhang
Department of Neurosurgery, Shengjing Hospital, China Medical University, PR China.
Yunhui
Y
Liu
Department of Neurobiology, China Medical University, PR China.
Yixue
Y
Xue
Department of Neurosurgery, Mayo Clinic, MN, United States.
Ian
I
Parney
D060890:B7-H1 Antigen / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology*; D049109:Cell Proliferation; D019317:Evidence-Based Medicine; D005910:Glioma / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008954:Models, Biological; D009361:Neoplasm Invasiveness
D060890:B7-H1 Antigen; C423236:CD274 protein, human