HIV-associated Neurocognitive Disorders and Antiretroviral Therapy: Current Concepts and Controversies.
Antiretroviral drugs may help prevent neurological decline in individuals with HIV infection by suppressing viral replication and associated chronic immune activation in the central nervous system. However, HIV control in the brain may come at the price of drug-induced neurotoxicity. Herein, we review recent advances in the balance between adequate viral suppression in the nervous system and adverse effects of the medications used in HIV treatment.
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA, metherton@partners.org.
Mark R
MR
Etherton
Jennifer L
JL
Lyons
Kevin L
KL
Ard