Prognostic role of YB-1 expression in breast cancer: a meta-analysis.
OBJECTIVE
In published studies, Y-box binding protein-1 (YB-1) correlated with the prognosis of patients with breast cancer (BC), but the specific role of YB-1 is still unclear. Our study aimed to evaluate the prognostic value of YB-1 in BC patients using meta-analysis based on the published studies.


METHODS
We searched the relevant literatures deadline for June 2014 in databases, including PubMed, Embase, Medline and Cochrane library, and finally 8 studies were included in our study. Our study contained 1094 BC patients with 398 YB-1 positive and 696 YB-1 negative.


RESULTS
Our results showed that YB-1 abnormal expression did not correlated with the lymph node status [OR = 1.258, 95% CI = 0.895-1.769, P = 0.186], high histological grade [OR = 2.709, 95% CI = 0.861-8.530, P = 0.089], histological type [OR = 0.837, 95% CI = 0.526-1.331, P = 0.452], P53 status [OR = 2.006, 95% CI 0.686-5.865, P = 0.203] and PR [OR = 0.607, 95% CI = 0.347-1.061, P = 0.080] in BC patients. But YB-1 over-expression was associated with other unfavorable factors: ER negativity [OR = 0.604, 95% CI = 0.388-0.941, P = 0.026], HER2 positivity [OR = 3.841, 95% CI = 2.637-5.594, P = 0.000], and high tumorous T stage [OR = 2.169, 95% CI = 1.295-3.632, P = 0.003]. In addition, our data suggested that high YB-1 expression had an adverse impact on 5-year OS [RR = 2.767, 95% CI = 2.054-3.727, P = 0.000] in BC patients.


CONCLUSIONS
Our findings implied that YB-1 might a novel biomarker to predict the prognosis of BC, and could be a potential direction for developing diagnostic and therapeutic approaches in BC.
Department of General Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Xu
X
Wang
Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China.
Xiao-Bo
XB
Guo
Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Xiao-Chun
XC
Shen
Department of General Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Hao
H
Zhou
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510006, China.
Dan-Wei
DW
Wan
Department of General Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Xiao-Feng
XF
Xue
Department of General Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Ye
Y
Han
Department of General Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Bin
B
Yuan
Department of General Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Jin
J
Zhou
Department of General Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Hong
H
Zhao
Department of General Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Qiao-Ming
QM
Zhi
Department of General Surgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.
Yu-Ting
YT
Kuang
YB-1; breast cancer; meta-analysis; prognosis