Poor functional antibody responses are present in nearly all patients with chronic lymphocytic leukaemia, irrespective of total IgG concentration, and are associated with increased risk of infection.
Cancer Sciences, University of Birmingham, Birmingham, UK. parryhm@bham.ac.uk.
Helen M
HM
Parry
Department of Immunology, University of Birmingham, Birmingham, UK.
Jane
J
Birtwistle
Department of Immunology, University of Birmingham, Birmingham, UK.
Alison
A
Whitelegg
School of Medicine and Veterinary Science, University of Nottingham, Nottingham, UK.
Chris
C
Hudson
Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Tina
T
McSkeane
Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Peter
P
Hazlewood
University of Birmingham Medical School, Birmingham, UK.
Nyasha
N
Mudongo
Cancer Sciences, University of Birmingham, Birmingham, UK.
Guy
G
Pratt
Cancer Sciences, University of Birmingham, Birmingham, UK.
Paul
P
Moss
Department of Immunology, University of Birmingham, Birmingham, UK.
Mark T
MT
Drayson
Department of Haematology, University Hospital Birmingham, Birmingham, UK.
Jim
J
Murray
Cancer Sciences, University of Birmingham, Birmingham, UK.
Alex G
AG
Richter
D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007239:Infections / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D008297:Male; D012307:Risk Factors
D000906:Antibodies; D007074:Immunoglobulin G
chronic lymphocytic leukaemia; immunodeficiency; infection