Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes.
The aim of this study was to evaluate the association of plasma fibroblast growth factor (FGF)-21 with angiographically significant coronary artery disease (CAD) in patients with type 2 diabetes mellitus. Serum FGF-21 was measured in 120 patients undergoing coronary angiography. Patients were divided into 4 groups based on the presence/absence of type 2 diabetes mellitus and of significant CAD. The atherosclerotic burden was obtained by two angiographic scores: Gensini score (GS) and Extent score (ES). FGF-21 levels were higher in type 2 diabetes mellitus than in non-diabetic patients (P = 0.014). FGF-21 levels were significantly correlated with GS (r = 0.358, P < 0.001) and ES (r = 0.324, P < 0.001) in univariate analysis with all patients. After adjusting for several confounding factors, both GS and ES were associated with FGF-21 in all patients (r = 0.271, P = 0.014; r = 0.217, P = 0.041, respectively). However, FGF-21 lost significant correlation with both GS and ES with type 2 diabetes mellitus in the final model. The patients with type 2 diabetes mellitus and CAD feature had elevated FGF-21 levels. Despite of a limited role in diabetic patients, FGF-21 levels are independently associated with angiographic severity and extent of CAD.
Department of Internal Medicine, Pusan National University Hospital, Busan, Korea. ; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Won Jin
0000-0002-8918-2925
WJ
Kim
Department of Internal Medicine, Pusan National University Hospital, Busan, Korea. ; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Sang Soo
0000-0002-9687-8357
SS
Kim
Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Han Cheol
0000-0002-7236-4204
HC
Lee
Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Sang Heon
0000-0002-8218-6974
SH
Song
Kim Yong Ki Internal Medicine Clinic, Busan, Korea.
Min Jung
0000-0002-8506-944X
MJ
Bae
Busan Veterans Hospital, Busan, Korea.
Yang Seon
0000-0002-3544-2795
YS
Yi
Department of Internal Medicine, Pusan National University Hospital, Busan, Korea. ; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Yun Kyung
0000-0002-4319-5181
YK
Jeon
Department of Internal Medicine, Pusan National University Hospital, Busan, Korea. ; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Bo Hyun
0000-0001-9632-9457
BH
Kim
Kim Yong Ki Internal Medicine Clinic, Busan, Korea.
Yong Ki
0000-0001-9321-1736
YK
Kim
Department of Internal Medicine, Pusan National University Hospital, Busan, Korea. ; Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
In Joo
0000-0003-1307-6146
IJ
Kim
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012720:Severity of Illness Index; D055815:Young Adult
C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors
Coronary Artery Disease; Diabetes Mellitus, Type 2; Fibroblast Growth Factor-21