The First 50 Years of Molecular Pharmacology.
In this Perspective, former and current editors of Molecular Pharmacology, together with the guest editors for this 50th Anniversary Issue, provide a historical overview of the journal since its founding in 1965. The substantial impact that Molecular Pharmacology has had on the field of pharmacology as well as on biomedical science is discussed, as is the broad scope of the journal. The authors conclude that, true to the original goals for the journal, Molecular Pharmacology today remains an outstanding venue for work that provides a mechanistic understanding of drugs, molecular probes, and their biologic targets.
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California (J.H.B., P.A.I.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C.); Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C.); Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom (S.G.C.-C.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.D., S.F.T.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H.); and Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (G.M.).
Joan Heller
JH
Brown
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California (J.H.B., P.A.I.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C.); Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C.); Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom (S.G.C.-C.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.D., S.F.T.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H.); and Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (G.M.).
William A
WA
Catterall
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California (J.H.B., P.A.I.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C.); Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C.); Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom (S.G.C.-C.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.D., S.F.T.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H.); and Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (G.M.).
P Jeffrey
PJ
Conn
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California (J.H.B., P.A.I.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C.); Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C.); Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom (S.G.C.-C.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.D., S.F.T.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H.); and Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (G.M.).
Stuart G
http://orcid.org/0000-0002-0831-8326
SG
Cull-Candy
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California (J.H.B., P.A.I.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C.); Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C.); Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom (S.G.C.-C.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.D., S.F.T.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H.); and Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (G.M.).
Ray
R
Dingledine
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California (J.H.B., P.A.I.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C.); Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C.); Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom (S.G.C.-C.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.D., S.F.T.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H.); and Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (G.M.).
T Kendall
TK
Harden
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California (J.H.B., P.A.I.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C.); Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C.); Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom (S.G.C.-C.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.D., S.F.T.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H.); and Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (G.M.).
Paul A
PA
Insel
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California (J.H.B., P.A.I.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C.); Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C.); Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom (S.G.C.-C.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.D., S.F.T.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H.); and Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (G.M.).
Graeme
http://orcid.org/0000-0002-6946-3519
G
Milligan
Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California (J.H.B., P.A.I.); Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington (W.A.C.); Department of Pharmacology, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee (P.J.C.); Department of Neuroscience, Physiology, and Pharmacology, University College London, London, United Kingdom (S.G.C.-C.); Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia (R.D., S.F.T.); Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina (T.K.H.); and Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (G.M.) strayne@emory.edu.
Stephen F
http://orcid.org/0000-0002-3750-9615
SF
Traynelis
D000818:Animals; D016503:Drug Delivery Systems; D049673:History, 20th Century; D006801:Humans; D010506:Periodicals as Topic / Q000639:trends*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010597:Pharmacogenetics / Q000266:history*
D004364:Pharmaceutical Preparations