Mineral and bone disorders in kidney transplant recipients: reversible, irreversible, and de novo abnormalities.
Given the advances in medical technologies related to kidney transplantation, the post-transplant graft survival rate and quality of life have improved dramatically. Nevertheless, post-transplant mortality rate still remains high as compared to the general population due to the development of cardiovascular events. It has recently been widely recognized that chronic kidney disease-mineral and bone disorders (CKD-MBD) significantly contribute to such poor prognosis at least in part. In the majority of kidney recipients, abnormal serum parameters for mineral and bone disorder (MBD), such as phosphorus, calcium, 1,25-dihydroxyvitamin D, parathyroid hormone and fibroblast growth factor 23, gradually return toward acceptable levels following the re-establishment of kidney function after transplantation; however, some irreversible abnormalities, developed as the result of long-term dialysis, persist, require treatment, or even progress after kidney transplantation. Thus, better management of CKD-MBD during pre-dialysis and dialysis period as well as after kidney transplantation is highly appreciated.
Division of Nephrology, Endocrinology and Metabolism, Department of Medicine, Tokai University School of Medicine, 143 Shimo-Kasuya, Isehara, Kanagawa, 259-1193, Japan.
Takashi
T
Hirukawa
Takatoshi
T
Kakuta
Michio
M
Nakamura
Masafumi
M
Fukagawa
D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D006801:Humans; D016030:Kidney Transplantation; D011183:Postoperative Complications / Q000209:etiology* / Q000401:mortality / Q000628:therapy