Intraoperative burst suppression is associated with postoperative delirium following cardiac surgery: a prospective, observational study.
BACKGROUND
Postoperative delirium (POD) occurs frequently after cardiac surgery and is associated with increased morbidity and mortality. We analysed whether perioperative bilateral BIS monitoring may detect abnormalities before the onset of POD in cardiac surgery patients.


METHODS
In a prospective observational study, 81 patients undergoing cardiac surgery were included. Bilateral Bispectral Index (BIS)-monitoring was applied during the pre-, intra- and postoperative period, and BIS, EEG Asymmetry (ASYM), and Burst Suppression Ratio (BSR) were recorded. POD was diagnosed according to the Confusion Assessment Method for the Intensive Care Unit, and patients were divided into a delirium and non-delirium group.


RESULTS
POD was detected in 26 patients (32%). A trend towards a lower ASYM was observed in the delirium group as compared to the non-delirium group on the preoperative day (ASYM = 48.2 ± 3.6% versus 50.0 ± 4.7%, mean ± sd, p = 0.087) as well as before induction of anaesthesia, with oral midazolam anxiolysis (median ASYM = 49.5%, IQR [47.4;51.5] versus 50.6%, IQR [49.1;54.2], p = 0.081). Delirious patients remained significantly (p = 0.018) longer in a burst suppression state intraoperatively (107 minutes, IQR [47;170] versus 44 minutes, IQR [11;120]) than non-delirious patients. Receiver operating analysis revealed burst suppression duration (area under the curve = 0.73, p = 0.001) and BSR (AUC = 0.68, p = 0.009) as predictors of POD.


CONCLUSIONS
Intraoperative assessment of BSR may identify patients at risk of POD and should be investigated in further studies. So far it remains unknown whether there is a causal relationship or rather an association between intraoperative burst suppression and the development of POD.


BACKGROUND
clinicaltrials.gov NCT01048775.
Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany. martin.soehle@ukb.uni-bonn.de.
Martin
M
Soehle
Department of Neurology and Psychiatry, LVR-Clinic, Bonn, Germany. alexander.dittmann@uni-bonn.de.
Alexander
A
Dittmann
Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany. richard.ellerkmann@ukb.uni-bonn.de.
Richard K
RK
Ellerkmann
Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany. georg.baumgarten@ukb.uni-bonn.de.
Georg
G
Baumgarten
Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany. christian.putensen@ukb.uni-bonn.de.
Christian
C
Putensen
Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany. ulf.guenther@ukb.uni-bonn.de.
Ulf
U
Guenther
D000368:Aged; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D056805:Consciousness Monitors; D003693:Delirium / Q000209:etiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies