Cell-Based Approaches in Periodontal Regeneration: A Systematic Review and Meta-Analysis of Periodontal Defect Models in Animal Experimental Work.
Various cell types have been assessed for experimental periodontal tissue regeneration in a variety of animal models. Nonetheless, the efficacy of cell-based approaches for periodontal regeneration is still controversial. Therefore, the purpose of this study was to systematically review cell-based approaches for periodontal regeneration in animal studies including a meta-analysis to obtain more clarity on their efficacy. The results of this systematic review and meta-analysis revealed that cell-based approaches have a favorable effect on periodontal tissue regeneration, as displayed by the positive effect of cell-based approaches on new bone, cementum, and periodontal ligament (PDL) formation in periodontal defects. Moreover, subgroup analysis showed a favorable effect on PDL formation by PDL-derived cells, but not by bone marrow mesenchymal stem cells (BMSCs). However, meta-analysis did not show any statistically significant differences in effect between PDL-derived cells and BMSCs. These results provide important information for the implementation of cell-based approaches in clinical practice as a routine treatment for periodontal regeneration in the future.
1 Radboudumc, Department of Biomaterials, Nijmegen, The Netherlands .|2 Department of Periodontology, the Affiliated Stomatology Hospital of Tongji University , Shanghai, China .
Xiang-Zhen
XZ
Yan
1 Radboudumc, Department of Biomaterials, Nijmegen, The Netherlands .
Fang
F
Yang
1 Radboudumc, Department of Biomaterials, Nijmegen, The Netherlands .
John A
JA
Jansen
3 Radboudumc, SYstematic Review Centre for Laboratory animal Experimentation (SYRCLE) , Central Animal Laboratory, Nijmegen, The Netherlands .
Rob B M
RB
de Vries
1 Radboudumc, Department of Biomaterials, Nijmegen, The Netherlands .
Jeroen J J P
JJ
van den Beucken
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D010518:Periodontitis / Q000503:physiopathology / Q000628:therapy*; D010519:Periodontium / Q000503:physiopathology*; D051381:Rats; D012038:Regeneration; D013552:Swine; D013556:Swine, Miniature