Shelterin proteins and cancer.
The telomeric end structures of the DNA are known to contain tandem repeats of TTAGGG sequence bound with specialised protein complex called the "shelterin complex". It comprises six proteins, namely TRF1, TRF2, TIN2, POT1, TPP1 and RAP1. All of these assemble together to form a complex with double strand and single strand DNA repeats at the telomere. Such an association contributes to telomere stability and its protection from undesirable DNA damage control-specific responses. However, any alteration in the structure and function of any of these proteins may lead to undesirable DNA damage responses and thus cellular senescence and death. In our review, we throw light on how mutations in the proteins belonging to the shelterin complex may lead to various malfunctions and ultimately have a role in tumorigenesis and cancer progression.
Department of Medical Biotechnology, Vellore Institute of Technology, Vellore, Tamilnadu, India E-mail : Dr.TNPatel@gmail.com, tnpatel@vit.ac.in.
Trupti Nv
TN
Patel
Richa
R
Vasan
Divanshu
D
Gupta
Jay
J
Patel
Manjari
M
Trivedi
D000818:Animals; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D000089804:Shelterin Complex / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000235:genetics / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D035341:Telomeric Repeat Binding Protein 2 / Q000235:genetics / Q000378:metabolism*; D000091346:Tripeptidyl-Peptidase 1
D000089804:Shelterin Complex; D034501:Telomere-Binding Proteins; D035341:Telomeric Repeat Binding Protein 2; C495876:ACD protein, human; C534796:TRF2 protein, mouse; C000717268:Tpp1 protein, mouse; D000091346:Tripeptidyl-Peptidase 1