Periodontal status and pathogenic bacteria after gastric bypass: a cohort study.
OBJECTIVE
The aim this study was to evaluate the influence of gastric bypass surgery (GBS) on periodontal disease and quantify the periodontopathogenic bacteria in patients undergoing this surgery.


METHODS
This prospective study was composed of 50 patients who underwent bariatric surgery and the data collection was performed in three periods pre-operative, 6 (6M) and 12 months (12 M) postoperative. The oral clinical examination to assess periodontal disease; gingival fluid sample collection for quantification of the periodontopathogenic bacteria Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Prevotella intermedia using q-PCR; body mass index (BMI) and for collection of the individual's health-related data from medical files.


RESULTS
There was a significant reduction in serum C-reactive protein (CRP) and glucose levels after surgery. The mean probing pocket depth (PPD) and clinical attachment level (CAL) increased significantly in the postoperative period of 6 months (p = 0.001). In the same period, the amount of P. gingivalis increased (p = 0.028) and the other bacteria decreased slightly (p > 0.050). In the presence of P. gingivalis, T. forsythia, T. denticola and P. intermedia, a poor periodontal condition was observed.


CONCLUSIONS
The periodontal disease increased in severity and P. gingivalis increased after GBS. A systemic inflammation resolution due to bariatric surgery in obese subjects does not seem to affect the course of periodontal disease.
Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
Sílvia Helena de Carvalho
SH
Sales-Peres
Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
Patrícia Garcia
PG
de Moura-Grec
Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
Joselene Martinelli
JM
Yamashita
Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
Elza Araujo
EA
Torres
Department Biological Science, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
Thiago José
TJ
Dionísio
Botucatu School of Medicine, Botucatu, Brazil.
Celso Vieira de Souza
CV
Leite
Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
Arsenio
A
Sales-Peres
Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.
Reginaldo
R
Ceneviva
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D015331:Cohort Studies; D003728:Dental Calculus / Q000145:classification; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass / Q000379:methods*; D005883:Gingival Crevicular Fluid / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification / Q000382:microbiology; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000302:isolation & purification; D018713:Prevotella intermedia / Q000302:isolation & purification; D011446:Prospective Studies; D000070436:Tannerella forsythia / Q000302:isolation & purification; D048373:Treponema denticola / Q000302:isolation & purification; D015431:Weight Loss
D001786:Blood Glucose; D002097:C-Reactive Protein
Porphyromonas gingivalis; bariatric surgery; obesity; periodontal diseases; polymerase chain reaction