Effect of radiotherapy on moderate and severe thyroid associated ophthalmopathy: a double blind and self-controlled study.
OBJECTIVE
The effect of radiotherapy on moderate and severe Thyroid associated ophthalmopathy (TAO) was evaluated by various objective and quantitative indexes including T2 signal intensity ratios of orbital MRI inferior rectus and ipsilateral temporal muscle (T2SIR), extraocular muscles (EOM) volume, and the degree of exophthalmos using clinical research with prospective, randomized, double blind, self controlled.


METHODS
The patients with TAO who in the moderate and severe active period and had similar double eyes condition in the Outpatient Department of Ophthalmology of Xiangya No. 2 Hospital of Central South University from 2011.2 to 2014.2 were selected as objects in this study. The related body check was finished after the research group was built. For the object, one eye of patient having random radiotherapy was chosen as the experimental eye. The other eye in the same patient with pseudo radiotherapy (merely known by operator, doctors in department of ophthalmology and patients were double blind) was selected as the control eye. The radiotherapy plan was made by the operator according to the CT results. The T2 signal intensity ratios of orbital MRI inferior rectus and ipsilateral temporal muscle (T2SIR), extraocular muscles (EOM) volume, and the exophthalmos degree was compared by MRI check to evaluate the effect of radiotherapy.


RESULTS
The T2 signal intensity ratios of orbital MRI inferior rectus and ipsilateral temporal muscle (T2SIR), extraocular muscles (EOM) volume, and the exophthalmos degree between both eyes (experimental and control eyes) had significant differences and these data had statistical significance.


CONCLUSIONS
The treatment of radiotherapy is effective for the TAO in the moderate and severe active period.
Department of Ophthalmology and Eye Research Center, The 2nd Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Yujie
Y
Wu
Department of Ophthalmology and Eye Research Center, The 2nd Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Boding
B
Tong
Department of Radiology, The 2nd Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Yongheng
Y
Luo
Department of Oncology, The 2nd Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Guiyuan
G
Xie
Department of Ophthalmology and Eye Research Center, The 2nd Xiangya Hospital, Central South University Changsha 410011, Hunan, China.
Wei
W
Xiong
EOM volume; Moderate and severe thyroid associated ophthalmopathy; T2SIR; exophthalmos degree; radiotherapy