The outcomes of intracytoplasmic sperm injection and laser assisted hatching in women undergoing in vitro fertilization are affected by the cause of infertility.
BACKGROUND
We sought to determine the association between factors that affected clini- cal pregnancy and live birth rates in patients who underwent in vitro fertilization (IVF) and received intracytoplasmic sperm injection (ICSI) and/or laser assisted hatching (LAH), or neither.


METHODS
In this retrospective cohort study, the records of women who underwent IVF with or without ICSI and/or LAH at the Far Eastern Memorial Hospital, Taipei, Taiwan between January 2007 and December 2010 were reviewed. We divided patients into four groups: 1. those that did not receive ICSI or LAH, 2. those that received ICSI only, 3. those that received LAH only and 4. those that received both ICSI and LAH. Univariate and multivariate analyses were performed to determine factors associated with clinical pregnancy rate and live birth rate in each group.


RESULTS
A total of 375 women were included in the analysis. Oocyte number (OR=1.07) affected the live birth rate in patients that did not receive either ICSI or LAH. Mater- nal age (OR=0.89) and embryo transfer (ET) number (OR=1.59) affected the rate in those that received ICSI only. Female infertility factors other than tubal affected the rate (OR=5.92) in patients that received both ICSI and LAH. No factors were found to affect the live birth rate in patients that received LAH only.


CONCLUSIONS
Oocyte number, maternal age and ET number and female infertility fac- tors other than tubal affected the live birth rate in patients that did not receive ICSI or LAH, those that received ICSI only, and those that received both ICSI and LAH, respectively. No factors affected the live birth rate in patients that received LAH only. These data might assist in advising patients on the appropriateness of ICSI and LAH after failed IVF.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan.
Hsin-Fen
HF
Lu
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan.
Fu-Shiang
FS
Peng
Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.
Shee-Uan
SU
Chen
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan.
Bao-Chu
BC
Chiu
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan.
Szu-Hsing
SH
Yeh
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei, Taiwan.
Sheng-Mou
SM
Hsiao
Assisted Reproduction Technology; In Vitro Fertilization; Intracytoplasmic Sperm Injection