Hypoglycemic, lipid-lowering and metabolic regulation activities of metforminium decavanadate (H2Metf)3 [V10O28]·8H2O using hypercaloric-induced carbohydrate and lipid deregulation in Wistar rats as biological model.
Because of the increasing global spread of type 2 diabetes mellitus, there is a need to develop new antidiabetic agents. Recently we have synthesized new decavanadates using metformin as counterion. In particular, the compound containing three metforminium dications has been obtained in high yield and has been completely characterized. Biological studies using Wistar rats that have been fed with a high caloric diet inducing insulin resistance and metabolic syndrome were carried out. Results of the impact on key biochemical parameters mediated by metformin alone and the new compound are here presented. The metforminium decavanadate (H2Metf)3[V10O28]·8H2O, abbreviated as Metf-V10O28, was shown to have pharmacological potential as a hypoglycemic, lipid-lowering and metabolic regulator, since the resulting compound made of the two components with antidiabetic activities, reduces both dosage and time of administration (twice a week). Hence, due to the beneficial effects induced by the metforminium decavanadate we recommend to continue the exploration into the mechanism and toxicology of this new compound.
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, 14 Sur y Av. San Claudio, Col. San Manuel, CP 72570 Puebla, PUE, Mexico.
Samuel
S
Treviño
Centro de Química, ICUAP, Benemérita Universidad Autónoma de Puebla, 14 Sur y Av. San Claudio, Col. San Manuel, CP 72570 Puebla, PUE, Mexico.
Eduardo
E
Sánchez-Lara
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, 14 Sur y Av. San Claudio, Col. San Manuel, CP 72570 Puebla, PUE, Mexico.
Víctor Enrique
VE
Sarmiento-Ortega
Centro de Química, ICUAP, Benemérita Universidad Autónoma de Puebla, 14 Sur y Av. San Claudio, Col. San Manuel, CP 72570 Puebla, PUE, Mexico.
Irma
I
Sánchez-Lombardo
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, 14 Sur y Av. San Claudio, Col. San Manuel, CP 72570 Puebla, PUE, Mexico.
José Ángel
JÁ
Flores-Hernández
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, 14 Sur y Av. San Claudio, Col. San Manuel, CP 72570 Puebla, PUE, Mexico.
Aarón
A
Pérez-Benítez
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, 14 Sur y Av. San Claudio, Col. San Manuel, CP 72570 Puebla, PUE, Mexico.
Eduardo
E
Brambila-Colombres
Centro de Química, ICUAP, Benemérita Universidad Autónoma de Puebla, 14 Sur y Av. San Claudio, Col. San Manuel, CP 72570 Puebla, PUE, Mexico. Electronic address: enrique.gonzalez@correo.buap.mx.
Enrique
E
González-Vergara
D000818:Animals; D050260:Carbohydrate Metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D044882:Glucose Metabolism Disorders / Q000188:drug therapy*; D006949:Hyperlipidemias / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D050356:Lipid Metabolism; D008297:Male; D008687:Metformin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014638:Vanadates / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use*
D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D014638:Vanadates; D008687:Metformin
Bioinorganic vanadium chemistry; Decavanadate; Diabetes; Metabolic syndrome; Metformin