Using Small Molecules to Prepare Vesicles with Designable Shapes and Sizes via Frame-Guided Assembly Strategy.
Following the principle of frame-guided assembly (FGA), a small amphiphilic molecule, sodium dodecyl sulfate, is shown to form vesicles with cholesterol as the leading hydrophobic group. These findings not only demonstrate the generality of the FGA but also provide a clue to understand the formation mechanism of the cell membrane, and even the origin of life.
Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Yuanchen
Y
Dong
Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Zhongqiang
Z
Yang
Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Dongsheng
D
Liu
D002784:Cholesterol / Q000737:chemistry*; D004277:DNA, Single-Stranded / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008051:Lipid Bilayers / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D036103:Nanotechnology / Q000379:methods*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013696:Temperature
D004277:DNA, Single-Stranded; D008051:Lipid Bilayers; D012967:Sodium Dodecyl Sulfate; D006046:Gold; D002784:Cholesterol
amphiphiles; frame guided assembly; leading hydrophobic groups; small molecule; vesicles