[Dynamics of growth factors in the spleen and liver of rats at different stages of metastatic hepatic reconstitution].
The aim--to study the dynamics of IGF-I, IGS-II, TGF-β1 in liver and spleen tissues from rats at different stages of liver metastases.


METHODS
We have designed a model of liver metastases in male rats. The content of growth factors was examined by ELISA at 1, 2 and 5 weeks of carcinogenesis in tissue of liver and tumors of spleen.


RESULTS
The content of growth factors increased in liver tissue at different stages of metastasis. The concentration of TGF-β, increased from the first to the fifth week of carcinogenesis. The level of IGF-I increased after 2 weeks of carcinogenesis. CONCLUSION. Pathogenetic moments of metastasis to the liver are the change of growth factors levels, indicating intensification of metastasis from 2 weeks of carcinogenesis and proliferation from 1 to 5 weeks.
E M
EM
Frantsiiants
I V
IV
Kaplieva
L K
LK
Trepitaki
Iu A
IuA
Pogorelova
D000818:Animals; D045744:Cell Line, Tumor; D007124:Immunoenzyme Techniques; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000556:secondary*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000473:pathology; D013154:Spleen / Q000378:metabolism* / Q000473:pathology; D013160:Splenic Neoplasms / Q000378:metabolism* / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000032:analysis* / Q000378:metabolism
D053773:Transforming Growth Factor beta1; C548904:insulin-like growth factor-1, rat; D007334:Insulin-Like Growth Factor I