Successful treatment of ulcerative bronchiolitis in a woman with refractory Mycobacterium intracellulare infection.
We present a case of a woman with medically refractory ulcerative colitis (UC) who developed severe bronchiectasis, bronchitis, bronchiolitis and Mycobacterium intracellulare (MAC) infection 2 years after total colectomy. Despite being on optimal therapy for her MAC and sterilising multiple consecutive sputum cultures, she remained highly symptomatic, and this led to further investigations that revealed the presence of UC-related airways disease. Addition of immunosuppressive therapy to her antimycobacterial treatment resulted in sustained and complete clinical remission of her disease. To our knowledge, this is the only case published in the literature that describes a case of successful treatment of concomitant UC-related pulmonary disease and symptomatic MAC.
Division of Pulmonary, Critical Care and Sleep, New York University Langone Medical Center, New York, New York, USA.
John Patrick
JP
Egan
Department of Interventional Pulmonology, Chicago Chest Center, Elk Grove Village, Illinois, USA.
Benjamin J
BJ
Seides
National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Kenneth N
KN
Olivier
Division of Pulmonary, Critical Care and Sleep, New York University Langone Medical Center, New York, New York, USA.
Doreen
D
Addrizzo-Harris
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001987:Bronchiectasis / Q000188:drug therapy / Q000209:etiology; D001988:Bronchiolitis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000150:complications* / Q000601:surgery; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008168:Lung / Q000382:microbiology*; D008875:Middle Aged; D015269:Mycobacterium avium Complex; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy* / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents