Anaplastic pleomorphic xanthoastrocytoma with spinal leptomeningeal spread at the time of diagnosis in an adult.
We describe the first patient, to our knowledge, with anaplastic pleomorphic xanthoastrocytoma (PXA) with spinal leptomeningeal spread at the time of diagnosis and present a review of the literature. PXA is a tumor that typically has an indolent course but occasionally, when anaplastic features are present, behaves in a more aggressive manner. We found that PXA with spinal leptomeningeal spread at the time of diagnosis confers a worse prognosis. Craniospinal imaging should be obtained at time of diagnosis of PXA and the presence of leptomeningeal spread may be indicative of a more aggressive disease process.
Department of Neurosurgery, New York University Langone Medical Center, Suite 8R, 550 First Avenue, New York, NY 10016, USA. Electronic address: Carolina.benjamin@nyumc.org.
Carolina
C
Benjamin
Department of Neurosurgery, New York University Langone Medical Center, Suite 8R, 550 First Avenue, New York, NY 10016, USA.
Arline
A
Faustin
Department of Neurosurgery, New York University Langone Medical Center, Suite 8R, 550 First Avenue, New York, NY 10016, USA.
Matija
M
Snuderl
Department of Neurosurgery, New York University Langone Medical Center, Suite 8R, 550 First Avenue, New York, NY 10016, USA.
Donato
D
Pacione
D000368:Aged; D001254:Astrocytoma / Q000556:secondary*; D001932:Brain Neoplasms / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D055756:Meningeal Carcinomatosis / Q000556:secondary*; D014057:Tomography, X-Ray Computed / Q000379:methods
Anaplastic; Craniospinal dissemination; Glioma; Leptomeningeal spread; Pleomorphic xanthoastrocytoma