IgG4-Related Disease Presenting as a Solitary Neck Mass.
IgG4-related disease is a newly recognized entity associated with autoimmune conditions involving almost every organ system. It is characterized by elevated serum IgG4 as well as mass like tissue infiltration by IgG4-positive plasma cells. Imaging findings are nonspecific, vary depending on the site of disease, and include mass like enlargement of the salivary or lacrimal glands and enlarged lymph nodes. Radiographic findings often mimic malignancy, necessitating tissue sampling to confirm the diagnosis. Distinguishing IgG4-related disease from malignancy is important as IgG4 responds well to steroids and conservative management.
Department of Radiology, Georgia Regents University, Augusta, GA, USA.
Tyler
T
McKinnon
Department of Radiology, Georgia Regents University, Augusta, GA, USA.
William T
WT
Randazzo
Department of Pathology, Georgia Regents University, Augusta, GA, USA.
Brian D
BD
Kim
Department of Pathology, Georgia Regents University, Augusta, GA, USA.
Paul
P
Biddinger
Department of Radiology, Georgia Regents University, Augusta, GA, USA.
Scott
S
Forseen
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D062005:Biopsy, Large-Core Needle; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008206:Lymphatic Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D009333:Neck / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G
IgG4 related disease; autoimmune; neck mass; sclerosing disease