Correlation of creatine kinase with patency of stents using coronary computed tomography angiography.
OBJECTIVE
To explore the potential correlation between creatine kinase and the long-term patency of coronary drug eluting stents.


METHODS
The clinical data of 74 patients who had undergone coronary computed tomography angiography after drug eluting stents implantation were retrospecpectively analyzed. Based on the computed tomography angiography findings,these patients were divided into patency group and non-patency group. The mean follow-up time was (20.5 ± 13.1) months. The serum levels of creatine kinase and creatine kinase isoenzyme were measured to determine the relationship of stent patency with these oxidative-related biomarkers after long-term follow-up. The T test or non-parametric test was adopted to compare the intergroup difference of measurement data,whereas chi-square test was conducted to test the difference of enumeration data. Logistic regression was adopted to analyze the biochemical indexes and clinical information. Only variables with a P value of less than 0.05 in the univariable analyses entered the multivariate Logistic regression model.


RESULTS
Patients in the non-patency group had significantly higher serum creatine kinase level compared with patients in patency group [(115.5 ± 51.5)U/L vs.(75.9 ± 29.4)U/L, P=0.012] and significantly higher level of creatine kinase isoenzyme [(3.5 ± 5.3)U/L vs.(1.7 ± 1.3)U/L,P=0.034]. Furthermore,the Logistic analysis showed that serum creatine kinase level (odds ratio=1.573,95% CI=1.022-2.421, P=0.039)was an independent predictor of stent patency.


CONCLUSIONS
Creatine kinase is an independent risk factor associated with stent non-patency.
Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.
Ying-na
YN
Li
Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.
Xiang
X
Song
Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.
Fang
F
Wu
Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.
Shu-ping
SP
Tian
Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.
Hai-yue
HY
Ju
Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.
Li
L
Yang
D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003402:Creatine Kinase; D054855:Drug-Eluting Stents; D006801:Humans; D016015:Logistic Models; D012307:Risk Factors; D014054:Tomography; D014057:Tomography, X-Ray Computed
D003402:Creatine Kinase