Clinical significance of anaplasia in childhood rhabdomyosarcoma.
BACKGROUND
The presence of anaplastic features has been known to correlate with poor clinical outcome in various pediatric malignancies, including Wilms tumor and medulloblastoma but not in rhabdomyosarcoma.


OBJECTIVE
Aim was to study the frequency of anaplasia at presentation in childhood rhabdomyosarcoma and its relationship to clinical and pathological characteristics as well as to outcome.


METHODS
Anaplasia was retrospectively assessed in 105 consecutive pediatric rhabdomyosarcoma patients who were registered at the Children's Cancer Hospital in Egypt (CCHE) during the period from July 2007 till the end of May 2010.


RESULTS
Anaplasia was diagnosed in 18 patients (17.1%), focal in 10 (9.5%) and diffuse in 8 (7.6%). The distribution of anaplasia was found to be more common in older patients having age⩾10 years. Also it was more likely to occur in the high risk group and in tumors with unfavorable histology (alveolar subtype), and stage IV. The 3-year failure free survival rates for patients with and without anaplasia were 27.8±10.6% and 53.4±5.8%, respectively (p=0.014) and the 3-year overall survival rates were 35.3±11.6% and 61±6%, respectively (p=0.019).


CONCLUSIONS
The frequency of anaplasia in pediatric patients with rhabdomyosarcoma in our study was 17.1%. The presence of anaplasia had statistically significant worse clinical outcome.
Pediatric Oncology Department, Children Cancer Hospital Egypt (CCHE), National Cancer Institute, Cairo University, Egypt.
Iman
I
Sidhom
Pediatric Oncology Department, Children Cancer Hospital Egypt (CCHE), BeniSuef University, Egypt. Electronic address: elnadienas@gmail.com.
Enas
E
El Nadi
Pathology Department, Children Cancer Hospital Egypt (CCHE), National Cancer Institute, Cairo University, Egypt.
Hala
H
Taha
Pathology Department, Children Cancer Hospital Egypt (CCHE), National Cancer Institute, Cairo University, Egypt.
Naglaa
N
Elkinaai
Radiotherapy Department, Children Cancer Hospital Egypt (CCHE), National Cancer Institute, Cairo University, Egypt.
Mohamed S
MS
Zaghloul
Surgery Department, Children Cancer Hospital Egypt (CCHE), National Cancer Institute, Cairo University, Egypt.
Alaa
A
Younes
Research Department, Children Cancer Hospital Egypt (CCHE), Egypt.
Rania
R
Labib
Research Department, Children Cancer Hospital Egypt (CCHE), Egypt.
Mohamed
M
Sabry
D000293:Adolescent; D000367:Age Factors; D000708:Anaplasia / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004534:Egypt; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D016019:Survival Analysis; D016896:Treatment Outcome; D047368:Tumor Burden
Anaplasia; Prognostic significance; Rhabdomyosarcoma