Fiber probe for nonlinear imaging applications.
Over the past years it had been demonstrated that multimodal imaging combining the nonlinear modalities coherent anti-Stokes Raman scattering (CARS), two-photon excited auto-fluorescence (TPEF) and second harmonic generation (SHG) show a great potential for tissue diagnosis and tumor identification. To extend the applicability of this multimodal imaging approach for in-vivo tissue screening of difficult to access body regions the development of suitable fiber optic probes is required. Here we report about a novel CARS imaging fiber probe consisting of 10,000 coherent light guiding elements preserving the spatial relationship between the entrance and the output of the fiber. Therefore the scanning procedure can be shifted from the distal to the proximal end of the fiber probe and no moving parts or driving current are required to realize in-vivo CARS endoscopy.
Friedrich-Schiller University of Jena, Institute of Physical Chemistry and Abbe Center of Photonics, Helmholtzweg 4, 07743, Jena, Germany.|Leibniz Institute of Photonic Technology (IPHT), PO Box 100239, 07702, Jena, Germany.
Aleksandar
A
Lukić
Friedrich-Schiller University of Jena, Institute of Physical Chemistry and Abbe Center of Photonics, Helmholtzweg 4, 07743, Jena, Germany.|Leibniz Institute of Photonic Technology (IPHT), PO Box 100239, 07702, Jena, Germany.
Sebastian
S
Dochow
Friedrich-Schiller University of Jena, Institute of Physical Chemistry and Abbe Center of Photonics, Helmholtzweg 4, 07743, Jena, Germany.|Leibniz Institute of Photonic Technology (IPHT), PO Box 100239, 07702, Jena, Germany.
Olga
O
Chernavskaia
Friedrich-Schiller University of Jena, Institute of Physical Chemistry and Abbe Center of Photonics, Helmholtzweg 4, 07743, Jena, Germany.|Leibniz Institute of Photonic Technology (IPHT), PO Box 100239, 07702, Jena, Germany.
Ines
I
Latka
Friedrich-Schiller University of Jena, Institute of Physical Chemistry and Abbe Center of Photonics, Helmholtzweg 4, 07743, Jena, Germany.|Leibniz Institute of Photonic Technology (IPHT), PO Box 100239, 07702, Jena, Germany.
Christian
C
Matthäus
Leibniz Institute of Photonic Technology (IPHT), PO Box 100239, 07702, Jena, Germany.
Anka
A
Schwuchow
Leibniz Institute of Photonic Technology (IPHT), PO Box 100239, 07702, Jena, Germany.
Michael
M
Schmitt
Friedrich-Schiller University of Jena, Institute of Physical Chemistry and Abbe Center of Photonics, Helmholtzweg 4, 07743, Jena, Germany. juergen.popp@ipht-jena.de.|Leibniz Institute of Photonic Technology (IPHT), PO Box 100239, 07702, Jena, Germany. juergen.popp@ipht-jena.de.
Jürgen
J
Popp
D000818:Animals; D001011:Aorta / Q000166:cytology; D017711:Nonlinear Dynamics; D055100:Optical Fibers; D061848:Optical Imaging / Q000295:instrumentation*; D011817:Rabbits; D013059:Spectrum Analysis, Raman
diagnostic imaging; fiber optic technology; microscopy; multimodal imaging