Immunoadsorption with regenerating systems in neurological disorders --A single center experience.
In recent years, immunoadsorption is increasingly recognized as an alternative treatment approach replacing therapeutic plasma exchange in a variety of neurological disorders. While most experience is based on the application of single-use tryptophan adsorbers, less data exists on the application of more efficient regenerating adsorber columns. We here report the systematic use of a regenerating adsorber system in various neurological indications such as multiple sclerosis, encephalitis, myasthenia gravis and chronic inflammatory demyelinating polyneuropathy, providing the expected treatment success in regard to reduction of immunoglobulins and antibody clearance, together with a low rate of adverse events. As it has been shown for single-use columns before, immunoadsorption with regenerating adsorbers can be successfully applied in disorders without known specific antibodies such as multiple sclerosis. Regenerating systems offer the perspective to provide a more efficacious long term treatment perspective for such patients.
Extracorporeal Treatment and Apheresis Center, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany; Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany. Electronic address: bernd.hohenstein@uniklinikum-dresden.de.
Bernd
B
Hohenstein
Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.
Jens
J
Passauer
Department of Neurology, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.
Tjalf
T
Ziemssen
Extracorporeal Treatment and Apheresis Center, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.
Ulrich
U
Julius
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D015415:Biomarkers / Q000097:blood; D001781:Blood Component Removal / Q000009:adverse effects / Q000295:instrumentation*; D002648:Child; D004867:Equipment Design; D005260:Female; D005858:Germany; D006801:Humans; D007163:Immunosorbent Techniques / Q000009:adverse effects / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D010951:Plasma Exchange; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
D001323:Autoantibodies; D015415:Biomarkers
Immunoadsorption; Multiple sclerosis; Neurology; Plasma exchange