[Urine metabonomic study on long-term use of total ginsenosides in rats].
Due to its effect of systems regulation and promotion on body, Ginseng is always referred to be long-term used as a dietary supplement. But it was still unclear about its target of the tonic effects and also the side-effects long-term use may bring. Urine metabolomic method is suitable for long-term studies of pharmaco-dynamics, pharmacology and toxicology of traditional Chinese medicine because of its characteristics of non-invasive and monitoring the whole-body metabolism. This study was designed to detect the dynamic variation of rat urine metabolome along with a long-term administration of total ginsenosides using GC-TOF based metabolomic technology. Our result showed that either short-term or chronic administration of ginsenosides did not impact the rat urine metabolome significantly (as the PCA subgroup was not successful). By comparison, the short-term (1-3 w) dose of ginsenosides had the biggest metabolic influence including TCA cycle, catecholamines and neurotransmitter amino acids. Medium-term (6-10 w) dose had a gradually lower effect and long-term (27 w) dose almost had no effect. Our study indicates that both short and long-term administration of ginsenosides showed almost no obvious side-effect on the experimental animals.
Xie
X
Xie
Shao-Qiu
SQ
Chen
Ying-Fang
YF
Lv
Xiao-Yan
XY
Wang
Wei
W
Jia
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000378:metabolism*; D036145:Ginsenosides / Q000378:metabolism / Q000652:urine*; D008297:Male; D055432:Metabolomics; D005894:Panax / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides