Difluoromethylation and gem-difluorocyclopropenation with difluorocarbene generated by decarboxylation.
Difluoromethylation of the activated X-H bond (X = N, O and S) and aliphatic thiols, and gem-difluorocyclopropenation of alkynes with difluorocarbene generated in situ from difluoromethylene phosphobetaine (Ph3P(+)CF2CO2(-)) by decarboxylation occurred smoothly without the presence of any base or other additives.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. jchxiao@sioc.ac.cn.
Xiao-Yun
XY
Deng
Jin-Hong
JH
Lin
Jian
J
Zheng
Ji-Chang
JC
Xiao
D000480:Alkynes / Q000737:chemistry; D003653:Decarboxylation; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry
D000480:Alkynes; D006845:Hydrocarbons, Fluorinated; D013438:Sulfhydryl Compounds; C121084:difluorocarbene