β-Ga2O3:Cr(3+) nanoparticle: A new platform with near infrared photoluminescence for drug targeting delivery and bio-imaging simultaneously.
Multifunctional nanoparticles which integrate the therapeutic agents and bio-imaging agents into one carrier are emerging as a promising therapeutic platform. Herein, GaOOH:Cr(3+) was firstly synthesized using improved hydrothermal method (atmospheric pressure, 95 °C), and by manipulating the pH of the reaction medium, GaOOH:Cr(3+) with different sizes (125.70 nm, 200.60 nm and 313.90 nm) were synthesized. Then β-Ga2O3:Cr(3+) nanoparticles with porous structures were developed as a result of the calcination of GaOOH:Cr(3+). The fabricated, porous β-Ga2O3:Cr(3+) nanoparticles could effectively absorb doxorubicin hydrochloride (DOX) (loading rate: 8% approximately) and had near infrared photoluminescence with a 695 nm emission. Furthermore, β-Ga2O3:Cr(3+) nanoparticles were coated with l-Cys modified hyaluronic acid (HA-Cys) by exploiting the electrostatic interaction and the cross-link effect of disulfide bond to improve the stability. The DOX loaded HA-Cys coated β-Ga2O3:Cr(3+) nanoparticles (HA/β-Ga2O3:Cr(3+)/DOX) showed an oxidation-reduction sensitive drug release behavior. The HA-Cys coated β-Ga2O3:Cr(3+) nanoparticles showed a low cytotoxicity on MCF-7 and Hela cell lines. The cellular uptake of HA/β-Ga2O3:Cr(3+)/DOX using the near infrared photoluminescence of β-Ga2O3:Cr(3+) nanoparticles and the fluorescence of DOX demonstrated the HA/β-Ga2O3:Cr(3+)/DOX could internalize into tumor cells quickly, which was affected by the size and shape of β-Ga2O3:Cr(3+)nanoparticles.
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, PR China.
Xin-Shi
XS
Wang
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, PR China.
Jun-Qing
JQ
Situ
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, PR China.
Xiao-Ying
XY
Ying
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, PR China.
Hui
H
Chen
Intensive Care Unit, The First Affiliated Hospital, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, PR China.
Hua-fei
HF
Pan
National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, 56 Yangming Road, 330006, PR China. Electronic address: jinyizju@hotmail.com.
Yi
Y
Jin
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, PR China. Electronic address: duyongzhong@zju.edu.cn.
Yong-Zhong
YZ
Du
D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002857:Chromium / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry; D003952:Diagnostic Imaging / Q000379:methods*; D004317:Doxorubicin / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D005708:Gallium / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D006820:Hyaluronic Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007259:Infrared Rays; D008163:Luminescent Measurements / Q000379:methods*; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D066244:Proton Magnetic Resonance Spectroscopy; D055672:Static Electricity; D014961:X-Ray Diffraction
D018960:Hyaluronan Receptors; D002857:Chromium; C038863:gallium oxide; D004317:Doxorubicin; D006820:Hyaluronic Acid; D005708:Gallium; D003545:Cysteine
Bio-imaging; Drug carrier; Hyaluronic acid; Nanoparticles; β-Ga(2)O(3):Cr(3+)