Health-Related Quality of Life in leukemia Survivors of Allogeneic Hematopoietic Stem Cell Transplantation Employing the Mexican Reduced-Intensity Conditioning.
BACKGROUND
Quality of life (QOL) is an important consideration in the counseling, implementation, and post-treatment management of arduous treatments for life-threatening conditions such as allogeneic hematopoietic cell transplantation (allo-HCT).


OBJECTIVE
To analyze the QOL of leukemia patients allografted with the Mexican reduced-intensity conditioning regimen in two Mexican academic medical centers.


METHODS
By means of the quality metric short form 36 version 2 to measure generic health concepts, relevant QOL was analyzed in leukemia patients who underwent allo-HCT using reduced-intensity conditioning on an outpatient basis at either the Centro de Hematología y Medicina Interna de Puebla of the Clínica Ruiz or the Hematology Service of the Internal Medicine Department of the Hospital "Dr. José Eleuterio González" of the Universidad Autónoma de Nuevo León, and who had survived more than 12 months after the allograft, who could be approached, who were in a continued complete remission (with or without graft-versus-host disease), and who were willing to respond to the questionnaire. Thirty-five patients fulfilling these requirements were included, and a sex- and age-matched group of 35 reference subjects was also studied.


RESULTS
Allografted patients were found to have a slightly better mental component summary than the reference subjects (53.23 vs. 48.66 points; p = 0.01), whereas the physical component summary did not show a difference (54.53 vs. 52.05 points; p = 0.59). Most of the differences between allografted individuals and reference subject controls were not significant.


CONCLUSIONS
Despite several sources of bias, these data suggest that allografted individuals employing the Mexican reduced-intensity conditioning regimen enjoy a health-related QOL life similar to that of reference subjects, adding another advantage of this method of conducting stem cell allografts. However, more work needs to be done to elucidate the impact of reduced-intensity conditioning on post allo-HCT QOL.
Centro de Hematología y Medicina Interna, Clínica RUIZ, Puebla, Pue., Mexico.|Universidad de las Américas Puebla, Puebla, Pue., Mexico.
Mónica P
MP
González-Ramírez
Universidad de las Américas Puebla, Puebla, Pue., Mexico.
Karla
K
Miravete-Lagunes
Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, N.L., Mexico.|Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
Andrés
A
Gómez-de-León
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F., Mexico.
Sergio
S
Ponce-de-León
Centro de Hematología y Medicina Interna, Clínica RUIZ, Puebla, Pue., Mexico.|Universidad de las Américas Puebla, Puebla, Pue., Mexico.
Andrea P
AP
Tenorio-Rojo
Centro de Hematología y Medicina Interna, Clínica RUIZ, Puebla, Pue., Mexico.|Universidad Popular Autónoma del Estado de Puebla, Puebla, Pue., Mexico.
Nora A
NA
Martagón-Herrera
Centro de Hematología y Medicina Interna, Clínica RUIZ, Puebla, Pue., Mexico.|Universidad del Valle de México, Campus Villahermosa, Tabasco, Tab., Mexico.
Jesús A
JA
Hernández-Reyes
Universidad de las Américas Puebla, Puebla, Pue., Mexico.
Arturo
A
García-Villasenor
Universidad de las Américas Puebla, Puebla, Pue., Mexico.
Esteban
E
Burguette
Universidad Popular Autónoma del Estado de Puebla, Puebla, Pue., Mexico.|Laboratorios Clínicos de Puebla, Clínica RUIZ, Puebla, Pue., Mexico.
María Fernanda
MF
Vallejo-Villalobos
Centro de Hematología y Medicina Interna, Clínica RUIZ, Puebla, Pue., Mexico.|Universidad Popular Autónoma del Estado de Puebla, Puebla, Pue., Mexico.|Laboratorios Clínicos de Puebla, Clínica RUIZ, Puebla, Pue., Mexico.
Guillermo J
GJ
Ruiz-Delgado
Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, N.L., Mexico.
David
D
Gómez-Almaguer
Centro de Hematología y Medicina Interna, Clínica RUIZ, Puebla, Pue., Mexico.|Universidad Popular Autónoma del Estado de Puebla, Puebla, Pue., Mexico.|Universidad de las Américas Puebla, Puebla, Pue., Mexico.|Laboratorios Clínicos de Puebla, Clínica RUIZ, Puebla, Pue., Mexico.
Guillermo J
GJ
Ruiz-Argüelles
D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D000368:Aged; D000073116:Cancer Survivors; D016022:Case-Control Studies; D005260:Female; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D055815:Young Adult