Why did Jacques Monod make the choice of mechanistic determinism?
The development of molecular biology placed in the foreground a mechanistic and deterministic conception of the functioning of macromolecules. In this article, I show that this conception was neither obvious, nor necessary. Taking Jacques Monod as a case study, I detail the way he gradually came loose from a statistical understanding of determinism to finally support a mechanistic understanding. The reasons of the choice made by Monod at the beginning of the 1950s can be understood only in the light of the general theoretical schema supported by the concept of mechanistic determinism. This schema articulates three fundamental notions for Monod, namely that of the rigidity of the sequence of the genetic program, that of the intrinsic stability of macromolecules (DNA and proteins), and that of the specificity of molecular interactions.
Université de Strasbourg (UDS), UMR 7363-DHVS/SAGE, 4, rue Kirschleger, 67000 Strasbourg, France. Electronic address: laurentloison@yahoo.fr.
Laurent
L
Loison
D004247:DNA / Q000737:chemistry*; D049673:History, 20th Century; D006801:Humans; D008967:Molecular Biology / Q000266:history*; D011506:Proteins / Q000737:chemistry*
D011506:Proteins; D004247:DNA
Biologie moléculaire; Determinism; Déterminisme; Jacques Monod; Mechanism; Molecular biology; Mécanisme