Drift in centrality of different brain regions in an anatomical neural network with Parkinson's disease: A view from complex network analysis.
Understanding the role of brain regions in anatomical neural networks with Parkinson's disease (PD) is essential for improving the clinical protocol or finding new targets for deep brain stimulation (DBS). Although numerous changes have been reported in local functional studies, few studies have reported on the anatomical network of the entire brain. Here, by developing a series of algorithms, this study provided a whole anatomical neural network of the macaque monkey. Then, the drifts in centrality from normal to PD networks were described in terms of complex network analysis and summarized with principal component analysis. Results revealed that the areas including the striatum, globus pallidus, amygdala, prefrontal lobe, thalamus, hippocampus, visual cortex, insula, etc., showed relatively notable drifts in their own patterns. The present study also demonstrated that the current targets of DBS shared a common feature: their centrality values being relatively low in the normal brain while intensely drifting with PD.
Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.
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Lei
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
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Huang
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
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Li
Sichuan University, Chengdu, Sichuan 610064, China.
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Jiang
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China; Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China. Electronic address: xthu@mail.kiz.ac.cn.
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Hu
Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China. Electronic address: brzhang@zju.edu.cn.
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Zhang
D000465:Algorithms; D000818:Animals; D001921:Brain / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008251:Macaca; D009010:Monte Carlo Method; D009415:Nerve Net / Q000473:pathology*; D059906:Neuroimaging / Q000379:methods*; D010300:Parkinson Disease / Q000473:pathology*
Parkinson’s disease; anatomical connectivity network; centrality; network analysis