Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells.
OBJECTIVE
To investigate the role of thrombospondin 1 (TSP-1) in RA.


METHODS
Expression of TSP-1 in synovial tissues was determined by immunohistochemistry. Expression of TSP-1 in rheumatoid fibroblast-like synovial cells (FLS) was investigated by quantitative real-time PCR and ELISA. Correlations among the plasma TSP-1 and other variables in patients with RA were examined.


RESULTS
Expression of TSP-1 was increased in rheumatoid synovial tissues. Transforming growth factor-β1 (TGF-β1) clearly increased TSP-1 expression in FLS on both mRNA and protein levels. Changes in plasma TSP-1 were associated with those in 28-joint Disease Activity Score-erythrocyte sedimentation rate and plasma TGF-β1.


CONCLUSIONS
TSP-1 might be critically involved in the disease process of RA through the TGF-β1/TSP-1 axis.
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Takahisa
T
Suzuki
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences. naoki-iwa@nagasaki-u.ac.jp.
Naoki
N
Iwamoto
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Satoshi
S
Yamasaki
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Ayako
A
Nishino
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Yoshikazu
Y
Nakashima
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Yoshiro
Y
Horai
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Shin-Ya
SY
Kawashiri
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Kunihiro
K
Ichinose
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Kazuhiko
K
Arima
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Mami
M
Tamai
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Hideki
H
Nakamura
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Tomoki
T
Origuchi
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Chikara
C
Miyamoto
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Makoto
M
Osaki
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Kaname
K
Ohyama
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Naotaka
N
Kuroda
From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.
Atsushi
A
Kawakami
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000235:genetics* / Q000503:physiopathology*; D015331:Cohort Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013583:Synovial Membrane / Q000166:cytology / Q000378:metabolism; D019700:Thrombospondin 1 / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D015854:Up-Regulation
D019700:Thrombospondin 1; D053773:Transforming Growth Factor beta1
BIOMARKER; FIBROBLAST-LIKE SYNOVIAL CELL; RHEUMATOID ARTHRITIS; SYNOVITIS; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR-Β1