TGFβ-1 and TGFBR2 polymorphisms, cooking oil fume exposure and risk of lung adenocarcinoma in Chinese nonsmoking females: a case control study.
BACKGROUND
Transforming growth factor-β (TGF-β) plays an important role in regulating cellular functions, and many studies have demonstrated important roles for TGF-β in various cancers. Single nucleotide polymorphisms (SNPs) of TGF-β may influence lung carcinogenesis. The aim of this study was to test whether TGF-β1 C509T and TGF-β receptor II (TGFBR2) G-875A polymorphisms were associated with lung adenocarcinoma in nonsmoking females.


METHODS
A hospital-based case-control study was performed in Chinese nonsmoking females. Genotyping was performed using TaqMan SNP genotyping assay, and demographic data and environmental exposure were collected by trained interviewers after informed consents were obtained.


RESULTS
A total of 272 (95.4%) cases and 313 (99.4%) controls were successfully genotyped, and the results showed that the polymorphic allele frequencies of C509T and G875A were similar among lung adenocarcinoma patients and controls (P=0.589 and 0.643, respectively). However, when the data were stratified for cooking oil fume exposure, the TT genotype of the TGFB1 C509T polymorphism showed a significantly decreased risk for lung adenocarcinoma compared with the CC genotype (adjusted OR=0.362, 95% CI=0.149-0.878, P=0.025).


CONCLUSIONS
TGF-β1 gene C509T polymorphism might be associated with decreased risk of lung adenocarcinoma in Chinese females exposed to cooking oil fumes, but no association was observed TGFBR2 gene G875A polymorphism.
Department of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. bin363534866@sina.com.|Liaoning Provincial Department of Education, Key Laboratory of Cancer Etiologic and Prevention (China Medical University), Liaoning, 110122, China. bin363534866@sina.com.
Yangwu
Y
Ren
Department of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. zhyin@mail.cmu.edu.cn.|Liaoning Provincial Department of Education, Key Laboratory of Cancer Etiologic and Prevention (China Medical University), Liaoning, 110122, China. zhyin@mail.cmu.edu.cn.
Zhihua
Z
Yin
Department of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. likun12360@hotmail.com.|Liaoning Provincial Department of Education, Key Laboratory of Cancer Etiologic and Prevention (China Medical University), Liaoning, 110122, China. likun12360@hotmail.com.
Kun
K
Li
Department of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. wy_epi2009@163.com.|Liaoning Provincial Department of Education, Key Laboratory of Cancer Etiologic and Prevention (China Medical University), Liaoning, 110122, China. wy_epi2009@163.com.
Yan
Y
Wan
Department of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. xlli@mail.cmu.edu.cn.|Liaoning Provincial Department of Education, Key Laboratory of Cancer Etiologic and Prevention (China Medical University), Liaoning, 110122, China. xlli@mail.cmu.edu.cn.
Xuelian
X
Li
Department of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. wuwei@mail.cmu.edu.cn.|Liaoning Provincial Department of Education, Key Laboratory of Cancer Etiologic and Prevention (China Medical University), Liaoning, 110122, China. wuwei@mail.cmu.edu.cn.
Wei
W
Wu
Department of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. pguan@mail.cmu.edu.cn.|Liaoning Provincial Department of Education, Key Laboratory of Cancer Etiologic and Prevention (China Medical University), Liaoning, 110122, China. pguan@mail.cmu.edu.cn.
Peng
P
Guan
Department of Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, People's Republic of China. bszhou@mail.cmu.edu.cn.|Liaoning Provincial Department of Education, Key Laboratory of Cancer Etiologic and Prevention (China Medical University), Liaoning, 110122, China. bszhou@mail.cmu.edu.cn.
Baosen
B
Zhou
D000230:Adenocarcinoma / Q000139:chemically induced / Q000235:genetics*; D000077192:Adenocarcinoma of Lung; D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003296:Cooking; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006761:Hospitals; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced / Q000235:genetics*; D009821:Oils / Q000009:adverse effects* / Q000737:chemistry; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D014835:Volatilization
D009821:Oils; D018125:Receptors, Transforming Growth Factor beta; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II