[Effect of multicomponent environment on intestinal permeability of puerarin in biopharmaceutics classification system of Chinese materia medica].
The evaluation of permeability in biopharmaceutics classification system of Chinese materia medica (CMMBCS) requires multicomponent as a whole in order to conduct research, even in the study of a specific component, should also be put in the multicomponent environment. Based on this principle, the high content components in Gegen Qinlian decoction were used as multicomponent environmental impact factors in the experiment, and the relevant parameters of intestinal permeability about puerarin were measured with using in situ single-pass intestinal perfusion model, to investigate and evaluate the intestinal permeability of puerarin with other high content components. The experimental results showed that different proportions of baicalin, glycyrrhizic acid and berberine had certain influence on intestinal permeability of puerarin, and glycyrrhizic acid could significantly inhibit the intestinal absorption of puerarin, moreover, high concentration of berberine could promote the absorption of puerarin. The research results indicated that the important research ideas of permeability evaluation in biopharmaceutics classification system of Chinese materia medica with fully considering the effects of other ingredients in multicomponent environment.
Yang
Y
Liu
Gang
G
Wang
Ling
L
Dong
Ming-Min
MM
Tang
Mei-Ling
ML
Zhu
Hong-Huant
HH
Dong
Cheng-Bo
CB
Hou
D000818:Animals; D001599:Berberine / Q000493:pharmacokinetics; D001702:Biopharmaceutics; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005419:Flavonoids / Q000493:pharmacokinetics; D019695:Glycyrrhizic Acid / Q000493:pharmacokinetics; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000737:chemistry; D007529:Isoflavones / Q000493:pharmacokinetics*; D007700:Kinetics; D008297:Male; D008419:Materia Medica / Q000493:pharmacokinetics*; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007529:Isoflavones; D008419:Materia Medica; D001599:Berberine; C038044:baicalin; D019695:Glycyrrhizic Acid; C033607:puerarin