Clinical characteristics and prognostic factors of gastroenteropancreatic neuroendocrine tumors: a single center experience in China.
OBJECTIVE
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a unique subgroup of tumors in the digestive system but with great clinical heterogeneity. The information on clinical characteristics and prognostic factors of Chinese patients is rather limited.


METHODS
We retrospectively analyzed the clinical features, prognostic factors of this disease in a consecutive cohort (N=294) between January 2007 and December 2012.


RESULTS
Functioning tumors accounted for 9.2%. Rectum was the most predominant GEP-NETs locations. Abdominal pain occurred in 46.5% patients which was the most common initial symptom. G1, G2 and G3 tumors accounted for 41.5%, 34.7% and 23.8%, respectively. Endoscopy provided the highest detection rate of 95.7%. Consistence between endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNAB) and surgically obtained histological Ki-67 index was 36.4%. Serum CgA test showed a 80.0% consistence with the tissue biopsy. The median follow up duration was 2.8 years (0.02-5.90 years), the median survival was 4.8 years, overall 5-year survival rate was 69.6%. We found colonic localization, tumor size larger than 20 mm, G3 tumor and metastasis were associated with worse outcome (p<0.05).


CONCLUSIONS
We found both consistence and differences in GEP-NETs characteristics between our study and previous reports.
Han-kui
HK
Hu
Neng-wen
NW
Ke
Ang
A
Li
Xiao-jiong
XJ
Du
Qiang
Q
Guo
Wei-ming
WM
Hu
D000328:Adult; D044466:Asian People; D049109:Cell Proliferation; D002681:China / Q000453:epidemiology; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D016145:Endoscopy, Digestive System; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000737:chemistry / Q000208:ethnology / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D018358:Neuroendocrine Tumors / Q000737:chemistry / Q000208:ethnology / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000208:ethnology / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000737:chemistry / Q000208:ethnology / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden
D019394:Ki-67 Antigen