Newcastle Disease Virus-Vectored H7 and H5 Live Vaccines Protect Chickens from Challenge with H7N9 or H5N1 Avian Influenza Viruses.
Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection.
Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Qinfang
Q
Liu
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ignacio
I
Mena
Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Jingjiao
J
Ma
Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Bhupinder
B
Bawa
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Florian
F
Krammer
Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Young S
YS
Lyoo
Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Yuekun
Y
Lang
Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Igor
I
Morozov
University of Udayana, Denpasar, Bali, Indonesia.
Gusti Ngurah
GN
Mahardika
Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA.
Wenjun
W
Ma
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA Adolfo.Garcia-Sastre@mssm.edu jricht@vet.k-state.edu.
Adolfo
A
García-Sastre
Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, Kansas, USA Adolfo.Garcia-Sastre@mssm.edu jricht@vet.k-state.edu.
Juergen A
JA
Richt
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002645:Chickens; D002681:China; D004337:Drug Carriers / Q000008:administration & dosage*; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics / Q000276:immunology*; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000276:immunology; D064766:Influenza A Virus, H7N9 Subtype / Q000235:genetics / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D005585:Influenza in Birds / Q000276:immunology / Q000517:prevention & control*; D009522:Newcastle disease virus / Q000235:genetics* / Q000254:growth & development; D016019:Survival Analysis; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology
D000914:Antibodies, Viral; D004337:Drug Carriers; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; C109963:hemagglutinin, avian influenza A virus