Durable viral suppression in an HIV-infected patient in the absence of antiretroviral therapy.
We describe the case of a young woman with an acute HIV infection characterized at onset by neurological features. The patient spontaneously controlled her HIV infection and recovered in a short period of time. The patient's clinical and virological history showed a peculiar evolution of HIV infection, with an MDR HIV-1 in CSF and a wild HIV strain in PBMCs. The patient's PBMC showed a rapid shift from a wild type to an MDR strain in few days.
Microbiology Section of the Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Italy.
Isabella
I
Bon
Microbiology Section of the Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Italy.
Giuseppina
G
Musumeci
Infectious Diseases Operative Unit, S. Maria delle Croci Hospital, Ravenna, Italy.
Michele
M
Pavoni
Microbiology Section of the Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Italy.
Anna
A
Miserocchi
Department of Infectious Parasitic and Immunomediated Diseases, Epidemiology Unit, Reference Centre on Phylogeny, Molecular Epidemiology and Microbial Evolution, Istituto Superiore di Sanità, Rome, I.
Alessandra
A
Lo Presti
Microbiology Section of the Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Italy.
Silvia
S
Morini
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Giacomo
G
Caio
Infectious Diseases Operative Unit, S. Maria delle Croci Hospital, Ravenna, Italy.
Agnese
A
Della Vittoria
Microbiology Section of the Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Italy.
Davide
D
Gibellini
Microbiology Section of the Department of Experimental, Diagnostic and Specialty Medicine, School of Medicine, University of Bologna, Italy; Interuniversity Consortium, INBB, Rome, Italy.
Maria Carla
MC
Re
D019380:Anti-HIV Agents / Q000494:pharmacology; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D006801:Humans; D010802:Phylogeny; D055815:Young Adult
D019380:Anti-HIV Agents
HIV; elite suppressor; neurological features; transmission events