Oral verruciform xanthoma: a clinicopathologic and immunohistochemical study of 20 cases.
Verruciform xanthoma of the oral cavity is an uncommon benign lesion that usually affects the palate and gingiva mainly as a well-circumscribed solitary yellowish to whitish plaque or nodule, which is promptly recognized microscopically by identification of sub-epithelial foamy macrophages. The aim of this study was to evaluate the clinicopathologic and immunohistochemical features of 20 cases of oral verruciform xanthoma. All cases were evaluated by conventional hematoxylin/eosin staining and six of those were submitted to immunohistochemical reactions for CD68, CD63, CD163, syndecan-1 (CD138), S-100 protein and cytokeratins (CK) 8, 14 and 19. Oral verruciform xanthoma presented as yellowish papillary nodules affecting mainly the palate (30%), buccal mucosa (30%) and gingiva (25%) of middle-aged male patients. Most cases presented papillary epithelial hyperplasia and sub-epithelial foamy cells, which were immunopositive for CD68, CD63 and CD163 in all cases. The orange parakeratin superficial layer was negative for CK14 and presented a distinct granular membrane pattern of positivity for CD138. S-100 protein, CK8, and CK19 were negative.
Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Bruno A B
BA
de Andrade
Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Michelle
M
Agostini
Oral Pathology, School of Dentistry, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
Fábio R
FR
Pires
Oral Pathology, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (FOP-UNICAMP), Piracicaba, Brazil.
Alicia
A
Rumayor
Pathology Section, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala.
Román
R
Carlos
Oral Pathology, School of Dentistry, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
Oslei P
OP
de Almeida
Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Mário J
MJ
Romañach
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000378:metabolism* / Q000473:pathology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D053668:Syndecan-1 / Q000378:metabolism; D060149:Tetraspanin 30 / Q000378:metabolism; D014973:Xanthomatosis / Q000378:metabolism* / Q000473:pathology*; D000098902:CD163 Antigen; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D007633:Keratins; D011956:Receptors, Cell Surface; D009418:S100 Proteins; D053668:Syndecan-1; D060149:Tetraspanin 30; D000098902:CD163 Antigen; C554586:CD63 protein, human; C067980:CD68 antigen, human; D000097382:CD68 Molecule
immunohistochemistry; oral cavity; syndecan-1; verruciform xanthoma