NFKB1 common variants and PPP1R13L and CD3EAP in relation to lung cancer risk in a Chinese population.
Genetic variations in NFKB1 have been associated with cancer risk. This investigation intended to evaluate the possible association between common variants in NFKB1 and lung cancer risk and gene-gene and gene-environment interactions. A study containing 384 Chinese lung cancer cases and 387 cancer-free controls was conducted. 5 htSNPs (rs3774934, rs13117745, rs230541, rs1801, rs3774965) in NFKB1 and interaction with common variants in NFKB1 and PPP1R13L and CD3EAP and smoking-duration were assessed. No association with lung cancer risk was detected for individual htSNP in four genetic models, but the haplotype consisting of the wild-type alleles of rs3774934(G), rs13117745(C), rs230541(A), and rs1801(G) was associated with lowered lung cancer risk after adjustment for smoking duration [OR (95% CI) = 0.71 (0.51-0.98), P = 0.036]. There was no interaction between NFKB1 polymorphisms and PPP1R13L and CD3EAP and smoking status in relation to lung cancer risk. Two significant models: smoking duration as main effect (P < 0.0010) and smoking duration-PPP1R13L rs1970764 combination (P = 0.0040-0.0050) were tested. The results suggest that NFKB1 common variants and smoking duration and smoking duration-PPP1R13L rs1970764 interaction could be concerned with the lung cancer development in a Chinese population. The present findings add to the evidence implicating inflammation in lung cancer etiology.
Key Laboratory of Environment and Population Health of Liaoning Education Ministry (Shenyang Medical College), Shenyang 110034, Liaoning Province, People's Republic of China. Electronic address: yinjye@163.com.
Jiaoyang
J
Yin
Department of orthopedics, Tianjin Fifth Center Hospital, Tianjin 300450, People's Republic of China.
Mengfan
M
Yin
National Research Centre for the Working Environment, Lerso Parkalle 105, DK-2100 Copenhagen O, Denmark.
Ulla
U
Vogel
Key Laboratory of Environment and Population Health of Liaoning Education Ministry (Shenyang Medical College), Shenyang 110034, Liaoning Province, People's Republic of China.
Yuhong
Y
Wu
Shenyang He Eye Hospital, Shenyang 110034, Liaoning Province, People's Republic of China.
Tao
T
Yao
Department of Morphology, Liaoning He Medical College, Shenyang 110163, Liaoning Province, People's Republic of China.
Yanhua
Y
Cheng
Key Laboratory of Environment and Population Health of Liaoning Education Ministry (Shenyang Medical College), Shenyang 110034, Liaoning Province, People's Republic of China.
Zhenxiang
Z
Sun
Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, People's Republic of China.
Wei
W
Hou
Key Laboratory of Environment and Population Health of Liaoning Education Ministry (Shenyang Medical College), Shenyang 110034, Liaoning Province, People's Republic of China.
Chunhong
C
Wang
D000368:Aged; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D052002:NF-kappa B p50 Subunit / Q000235:genetics*; D012318:RNA Polymerase I; D012097:Repressor Proteins / Q000235:genetics*; D012307:Risk Factors
D047908:Intracellular Signaling Peptides and Proteins; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; C119612:PPP1R13L protein, human; D012097:Repressor Proteins; C119975:POLR1G protein, human; D012318:RNA Polymerase I
Chinese; Common variants; Interaction; Lung cancer; NFKB1 and PPP1R13L and CD3EAP