Correlation between triggering receptor expressed on myeloid cells-1 and clinical disease activity in Chinese patients with ulcerative colitis.
The need for reliable biomarkers for monitoring disease activity in patients with ulcerative colitis (UC) is increasing. This study aimed at characterizing the correlation between serum sTREM-1 levels and diseases activity in Chinese patients with UC. Consecutive 76 patients with UC and 20 healthy subjects were prospectively enrolled. The disease activity of UC was assessed according to Mayo Score. Expression levels of TREM-1 in peripheral blood mononuclear cells (PBMCs) and serum sTREM-1 levels were evaluated at the time when the disease activity was determined. Other laboratory parameters, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also determined. Both TREM-1 expression levels in PBMCs and serum sTREM-1 levels from patients with UC were significantly increased compared to healthy subjects. In addition, the levels of TREM-1 expression and serum sTREM-1 were significantly elevated in UC patients with moderate or severe disease compared to the patients with quiescent or mild disease. More importantly, both levels of TREM-1 expression in PBMCs and serum sTREM-1 levels were significantly correlated with disease activity. The correlation between sTREM-1 and disease activity was higher than the correlations between CRP and disease activity or ESR and disease activity. Our findings suggest that serum sTREM-1 could be a potential serum biomarker for monitoring disease activity in Chinese patients with UC, and could be a promising surrogate for CRP and ESR.
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, China.
Shulan
S
Zhang
Division of Rheumatology, Department of Medicine, The Second Hospital of Shanxi Medical University Taiyuan, Shanxi 030001, China.
Jing
J
Luo
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, People's Republic of China ; Current address: Peking Union Medical College Press No. 9 Dong Dan San Tiao, Eastern District, Beijing 100005, People's Republic of China.
Bingbing
B
Shen
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, China.
Lijun
L
Li
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, China.
Chaojun
C
Hu
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, China.
Ping
P
Li
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, China.
Chuiwen
C
Deng
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, China.
Fengchun
F
Zhang
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, People's Republic of China.
Jiaming
J
Qian
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, China.
Yongzhe
Y
Li
Chinese patients; Ulcerative colitis (UC); disease activity; sTREM-1; triggering receptor expressed on myeloid cells-1 (TREM-1)