ESCRTs breach the nuclear border.
The endosomal sorting complexes required for transport (ESCRT) are best known for their role in sorting ubiquitylated membrane proteins into endosomes. The most ancient component of the ESCRT machinery is ESCRT-III, which is capable of oligomerizing into a helical filament that drives the invagination and scission of membranes aided by the AAA ATPase, Vps4, in several additional subcellular contexts. Our recent study broadens the work of ESCRT-III by identifying its role in a quality control pathway at the nuclear envelope (NE) that ensures the normal biogenesis of nuclear pore complexes (NPCs). Here, we will elaborate on how we envision this mechanism to progress and incorporate ESCRT-III into an emerging model of nuclear pore formation. Moreover, we speculate there are additional roles for the ESCRT-III machinery at the NE that broadly function to ensure its integrity and the maintenance of the nuclear compartment.
a Yale School of Medicine ; New Haven , CT , USA.
Brant M
BM
Webster
C Patrick
CP
Lusk
D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism*; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D056827:Endosomal Sorting Complexes Required for Transport / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011992:Endosomes / Q000737:chemistry / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D022022:Nuclear Pore / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D002843:Chromatin; D056827:Endosomal Sorting Complexes Required for Transport; C556514:Heh2 protein, S cerevisiae; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; C086449:POM152 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C107528:VPS4 protein, S cerevisiae; D000251:Adenosine Triphosphatases
ERAD, ER-Associated Degradation; ESCRT, Endosomal Sorting Complexes Required for Transport; INM, Inner Nuclear Membrane; LEM, Lap2, Emerin, MAN1; MVB, Multivesicular Body; NE, Nuclear Envelope; NLS, Nuclear Localization Signal; NPC, Nuclear Pore Complex; ONM, Outer Nuclear Membrane; SINC, Storage of Improperly assembled Nuclear pore Complexes; endosomal sorting complex required for transport; membrane curvature; nuclear envelope; nuclear pore complex; quality control