Protein synthesis in artificial cells: using compartmentalisation for spatial organisation in vesicle bioreactors.
Whereas spatial organisation of function is ubiquitous in biology, it has been lacking in artificial cells. We rectify this by using multi-compartment vesicles as chassis for artificial cells, allowing distinct biological processes to be isolated in space. This is demonstrated by in vitro synthesis of two proteins in predefined vesicle regions.
Department of Chemistry, Imperial College London, Exhibition Road, SW7 2AZ, UK. o.ces@imperial.ac.uk.
Yuval
Y
Elani
Robert V
RV
Law
Oscar
O
Ces
D058045:Artificial Cells / Q000737:chemistry / Q000378:metabolism*; D019149:Bioreactors; D002451:Cell Compartmentation; D014176:Protein Biosynthesis; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
D011506:Proteins