Nutraceuticals: Definition and Epidemiological Rationale for Their Use in Clinical Practice.
Cardiometabolic risk factors, such as hypercholesterolemia, hypertriglyceridemia, metabolic syndrome, diabetes, and arterial hypertension, are major predictors of the premature development of cardiovascular diseases (CVD). Since CVD prevention needs a life-course approach, beyond dietary and pharmacological treatment, non-pharmacological treatment should be considered an important alternative for patients in primary prevention with mild-moderate cardiometabolic risk factors at low-moderate global risk of CVD. Several functional foods and nutraceuticals are efficacious, safe and well tolerated. However, only some (monacolins of red yeast rice and omega-3 fatty acids) have showed, in long-term randomized clinical trials, a reduction of cardiovascular events.
Italian National Research Council, Rome, Italy, roberto.volpe@cnr.it.
Roberto
R
Volpe
Gianluca
G
Sotis
D002318:Cardiovascular Diseases / Q000517:prevention & control*; D019587:Dietary Supplements; D017408:Guidelines as Topic; D006801:Humans; D011322:Primary Prevention / Q000379:methods*; D012307:Risk Factors