Immobilization of Zidovudine Derivatives on the SBA-15 Mesoporous Silica and Evaluation of Their Cytotoxic Activity.
Novel zidovudine derivatives, able to be covalently conjugated to silica surface, have been obtained and grafted to SBA-15 mesoporous silica. Cytotoxic activity of the hybrid organic-inorganic (zidovudine derivatives-silica) systems against HeLa and KB cell lines has been analyzed. Addition of folic acid had a positive influence on the cytotoxicity. Up to 69% of HeLa and 65% of KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg/mL).
Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Dawid
D
Lewandowski
Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Marta
M
Lewandowska
Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
Piotr
P
Ruszkowski
Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
Anita
A
Pińska
Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Grzegorz
G
Schroeder
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D005492:Folic Acid / Q000008:administration & dosage; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D016062:Porosity; D012822:Silicon Dioxide; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; C509969:SBA-15; D015215:Zidovudine; D012822:Silicon Dioxide; D005492:Folic Acid