Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG.
The use of high dose chemotherapy followed by autologous hematopoietic stem cell transplantation for remission consolidation after initial induction represents standard of care for patients with multiple myeloma. Patients with myeloma and Acquired von Willebrand Syndrome (AVWS) undergoing autologous stem cell transplant (ASCT) are at significant risk of bleeding due to the profound thrombocytopenia, low Factor VIII levels, fever, and toxicities associated with the preparative regimen. We report a patient with AVWS associated with multiple myeloma who underwent autologous stem cell transplants as consolidation after initial induction and again at relapse. He was successfully treated with high dose intravenous immunoglobulin (IVIG) prior to each transplant with rapid resolution of AVWS.
Adult Blood and Marrow Transplant, Texas Transplant Institute, San Antonio, TX, USA ; Sarah Cannon Blood Cancer Network, Nashville, TN 37203, USA.
Behyar
B
Zoghi
Adult Blood and Marrow Transplant, Texas Transplant Institute, San Antonio, TX, USA ; Sarah Cannon Blood Cancer Network, Nashville, TN 37203, USA.
Paul
P
Shaughnessy
Cancer Care Centers of South Texas, 4411 Medical Drive, San Antonio, TX, USA.
Roger M
RM
Lyons
Texas Oncology, 901 W. 38th Street, Suite 200, Austin, TX 78705, USA.
Richard
R
Helmer
Adult Blood and Marrow Transplant, Texas Transplant Institute, San Antonio, TX, USA ; Sarah Cannon Blood Cancer Network, Nashville, TN 37203, USA.
Carlos
C
Bachier
Sarah Cannon Blood Cancer Network, Nashville, TN 37203, USA.
C Frederick
CF
LeMaistre