Fast vergence eye movements are disrupted in Parkinson's disease: A video-oculography study.
BACKGROUND
Blurred near vision is a common non-motor symptom in patients with Parkinson's disease (PD), however detailed characterization of vergence eye movements (VEM) is lacking.


METHODS
Convergence and divergence were examined in 18 patients with PD and 18 control subjects using infrared video-oculography. VEM metrics analyzed included latency, velocity and accuracy, in vertical and horizontal planes.


RESULTS
The latency of convergence and divergence was significantly increased in PD subjects. Additionally, divergence was slow and hypometric, while other convergence metrics were similar to controls.


CONCLUSIONS
We provide evidence in favor of disrupted VEM in PD.
Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Dept. of Neurosurgery, Hospital Na Homolce, Prague, Czech Republic.
Jaromír
J
Hanuška
Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; AP HP, Neurology Department, Pitié Salpêtrière Hospital, Paris, France.
Cecilia
C
Bonnet
Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Dept. of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic.
Jan
J
Rusz
Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Dept. of Cybernetics, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic.
Tomáš
T
Sieger
Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic.
Robert
R
Jech
CRICM UPMC/INSERM UMR_S975, CNRS UMR7225, ICM, Pitié-Salpêtrière Hospital, Paris, France; Pierre et Marie Curie Paris-6 University, Paris, France.
Sophie
S
Rivaud-Péchoux
AP HP, Neurology Department, Pitié Salpêtrière Hospital, Paris, France; CRICM UPMC/INSERM UMR_S975, CNRS UMR7225, ICM, Pitié-Salpêtrière Hospital, Paris, France; Pierre et Marie Curie Paris-6 University, Paris, France.
Marie
M
Vidailhet
CRICM UPMC/INSERM UMR_S975, CNRS UMR7225, ICM, Pitié-Salpêtrière Hospital, Paris, France; Pierre et Marie Curie Paris-6 University, Paris, France.
Bertrand
B
Gaymard
Dept. of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic. Electronic address: eruzi@lf1.cuni.cz.
Evžen
E
Růžička
D000328:Adult; D000368:Aged; D005133:Eye Movements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D010300:Parkinson Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D010775:Photic Stimulation / Q000379:methods; D014741:Video Recording / Q000379:methods*
Convergence; Divergence; Parkinson's disease; Vergence eye movements