High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer.
Our study aimed to investigate the association of Pyruvate Kinase isozyme type M2 (PKM2) with radiation resistance in locally advanced cervical squamous cell carcinoma (LACSCC). We retrospectively reviewed 132 female patients who received primary radiation therapy to treat LACSCC at Federation Internationale of Gynecologie and Obstetrigue (FIGO) stages IB-IVA. Forty-seven patients with progression free survival (PFS) of less than 36 months were regarded to have radiation resistance. Eighty-five patients with PFS no less than 36 months were regarded as radiation sensitive. Using immunohistochemistry, we found that the overexpression rate of PKM2 in radiation resistant and radiation sensitive patients was 87.2% and 57.6%, respectively, and the difference was statistically significant (p<0.001). The 5-year progress free survival rates in patients with low and high expression of PKM2 was 80.4% and 60.5%, respectively, and the difference was statistically significant (p=0.008). Multivariate Cox regression analysis identified that high expression of PKM2 is an independent negative prognostic factor in cervical cancer patients [Hazard ratio (95% CI), 2.888 (1.347, 6.194) p=0.006]. These results demonstrate that overexpression of PKM2 contributes to radiation resistance and acts a poor prognosis indicator in patients with LACSCC.
Department of Oncology, Xiangya Hospital, Central South University, Hunan Province, P.R. China.
Yajie
Y
Zhao
Department of Oncology, Xiangya Hospital, Central South University, Hunan Province, P.R. China.
Liangfang
L
Shen
Guangzhou Centers for Disease Control and Prevention, Guangdong Province, P.R. China.
Xi
X
Chen
Department of Oncology, Xiangya Hospital, Central South University, Hunan Province, P.R. China.
Yujie
Y
Qian
Department of Oncology, Xiangya Hospital, Central South University, Hunan Province, P.R. China.
Qin
Q
Zhou
Department of Oncology, Xiangya Hospital, Central South University, Hunan Province, P.R. China.
Ying
Y
Wang
Department of Oncology, Xiangya Hospital, Central South University, Hunan Province, P.R. China.
Kai
K
Li
Department of Oncology, Xiangya Hospital, Central South University, Hunan Province, P.R. China.
Miaomiao
M
Liu
Institute of Medical Science, Xiangya Hospital, Central South University, Hunan Province, P.R. China.
Sai
S
Zhang
Department of Oncology, Xiangya Hospital, Central South University, Hunan Province, P.R. China. wzyj7177@126.com.
Xinqiong
X
Huang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology / Q000532:radiotherapy*; D002352:Carrier Proteins / Q000032:analysis*; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008565:Membrane Proteins / Q000032:analysis*; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011836:Radiation Tolerance; D012189:Retrospective Studies; D012307:Risk Factors; D013963:Thyroid Hormones / Q000032:analysis*; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation; D002583:Uterine Cervical Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000532:radiotherapy*; D055815:Young Adult; D000097810:Thyroid Hormone-Binding Proteins
D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D008565:Membrane Proteins; D013963:Thyroid Hormones; D000097810:Thyroid Hormone-Binding Proteins