Five new cycloartane triterpenoids from Beesia calthifolia.
Phytochemical study on rhizomes of Beesia calthifolia resulted in the isolation of five new (1-5) and three known (6-8) cycloartane triterpenoids possessing a hemiketal or ketal group at C-24 from the EtOAc fraction of 95% ethanol extract. Their structures were determined by spectroscopic and chemical methods, especially HRMS and 2D NMR techniques. Compounds 3 and 4 showed potential hepatoprotective activities against D-galactosamine induced human hepatic L02 cell damage.
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China.
Dan-Jun
DJ
Zheng
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China.
Jing
J
Zhou
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China.
Qian
Q
Liu
Zhejiang Chemical Industry Research Institute Co., Ltd., 387 Tianmushan Rd., Hangzhou 310023, China.
Wei
W
Yao
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China.
Min-Zhe
MZ
Zhang
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China.
Bai-Hao
BH
Shao
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China.
Jian-Xia
JX
Mo
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China.
Chang-Xin
CX
Zhou
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China. Electronic address: lsgan@zju.edu.cn.
Li-She
LS
Gan
D002460:Cell Line; D005688:Galactosamine / Q000009:adverse effects; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D029626:Ranunculaceae / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry*
D014315:Triterpenes; C085352:cycloartane; D005688:Galactosamine
2D NMR; Beesia calthifolia; Cycloartane triterpenoid; Hepatoprotective activity