Synthesis and antihyperlipidemic activity of piperic acid derivatives.
A series of piperic acid derivatives were designed and synthesized from piperine/piperlonguminine, and their antihyperlipidemic activities evaluated in diet-induced hyperlipidemic rats with respect to simvastatin. Two promising analogues 3 and 10 were discovered and their antihyperlipidemic activities were comparable to or better than those of simvastatin.
Rong
R
A
Narisu
N
Bao
Zhaorigetu
Z
Sun
Gereltu
G
Borjihan
Yanjiang
Y
Qiao
Zhuang
Z
Jin
D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015394:Molecular Structure; D051381:Rats; D019821:Simvastatin / Q000494:pharmacology
D005231:Fatty Acids, Unsaturated; D000960:Hypolipidemic Agents; D019821:Simvastatin; C017637:piperic acid