An Italian population-based case-control study on the association between farming and cancer: Are pesticides a plausible risk factor?
This population-based case-control study investigated the association between farming (a proxy for pesticide exposure) and cancer in the Vercelli suburban area (northwest Italy). The residents, aged 25 to 79 years, in the above-mentioned area during the period 2002-2009 were considered. Cases were all the first hospital admissions for cancer. Controls were all the subjects not included in the cases and not excluded from the study. Cases and controls were classified according to whether they occupationally resulted farmers or nonfarmers during the period 1965-2009. Cancer odds ratios (ORs) between farmers and nonfarmers were calculated with generalized linear mixed models adjusted by gender and age. Farmers showed higher odds for all cancers (OR=1.459; p < .001), nonmelanoma skin cancer, colorectal cancer, and breast cancer. The results suggest a plausible association between pesticide exposure and cancer occurrence.
a Department of Translational Medicine , University of Eastern Piedmont "Amedeo Avogadro" , Novara , Italy.
Christian
C
Salerno
b Department of Brain and Behavioural Sciences , Section of Biostatistics, Neurophysiology and Psychiatry, Unit of Medical Statistics and Computational Genomics, Multivariate Statistics Laboratory, University of Pavia , Pavia , Italy.
Antonella
A
Carcagnì
c Department of Brain and Behavioural Sciences , Section of Biostatistics, Neurophysiology and Psychiatry, Unit of Medical Statistics and Computational Genomics, Clinical Epidemiology and Health Planning Laboratory, University of Pavia , Pavia , Italy.
Sara
S
Sacco
a Department of Translational Medicine , University of Eastern Piedmont "Amedeo Avogadro" , Novara , Italy.
Lucio Antonio
LA
Palin
d Health Services Research Group, School of Public Health, Faculty of Medicine, KU Leuven, University of Leuven , Leuven , Belgium.
Kris
K
Vanhaecht
a Department of Translational Medicine , University of Eastern Piedmont "Amedeo Avogadro" , Novara , Italy.
Massimiliano
M
Panella
b Department of Brain and Behavioural Sciences , Section of Biostatistics, Neurophysiology and Psychiatry, Unit of Medical Statistics and Computational Genomics, Multivariate Statistics Laboratory, University of Pavia , Pavia , Italy.
Davide
D
Guido
D000328:Adult; D000368:Aged; D000382:Agricultural Workers' Diseases / Q000453:epidemiology; D000383:Agriculture; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology*; D016273:Occupational Exposure; D010575:Pesticides / Q000506:poisoning*; D012307:Risk Factors
D010575:Pesticides
Cancer; Italy; Province of Vercelli; farmers; pesticides