Mir-196a-2 C>T polymorphism as a susceptibility factor for colorectal cancer.
OBJECTIVE
This study aimed to gain a better insight into the impact of the mir-196a-2 C>T polymorphism on the susceptibility to colorectal cancer (CRC).


METHODS
In a meta-analysis of 6 publications with a total of 1,754 cancer cases and 2,430 controls, we summarized the data on the associations between the studied mir-196a-2 C>T polymorphism and CRC risk and conducted subgroup analyses by ethnicity and control sources.


RESULTS
We found no overall association between the mir-196a-2 C>T polymorphism and CRC risk. But a significant association was found in the stratified analysis according to ethnicity among Asians (ORCC vs. TT = 1.22, 95% CI = 1.02-1.45, P heterogeneity = 0.718; ORCC vs. TC + TT = 1.22, 95% CI = 1.04-1.44, P heterogeneity = 0.590; ORallele C vs. allele T = 1.10, 95% CI = 1.01-1.20, P heterogeneity = 0.726) rather than Caucasians.


CONCLUSIONS
Our results suggested that there was no overall risk of CRC in relation to the mir-196a-2 C>T polymorphism. However, this polymorphism was associated with an increased risk in Asian populations.
The First Department of General Surgery, Cangzhou Central Hospital of Hebei Province Xinhua West Road No. 16, Xinhua District, Cangzhou 061001, Hebei Province, China.
Liang
L
Shi
Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine in Hebei Hebei Province, China.
Chongyang
C
Zhang
The Second Hospital of Hebei Medical University Hebei Province, China.
Dongqiang
D
Zhao
The First Department of General Surgery, Cangzhou Central Hospital of Hebei Province Xinhua West Road No. 16, Xinhua District, Cangzhou 061001, Hebei Province, China.
Kexia
K
Liu
The First Department of General Surgery, Cangzhou Central Hospital of Hebei Province Xinhua West Road No. 16, Xinhua District, Cangzhou 061001, Hebei Province, China.
Tiejun
T
Li
The Second Hospital of Hebei Medical University Hebei Province, China.
Hui
H
Tian
CRC; mir-196a-2 C>T; polymorphism; susceptibility