[Desmosine plasma levels and exacerbation risk assessment of chronic obstructive pulmonary disease].
OBJECTIVE
To explore the relationship between desmosine plasma levels and exacerbation risk in patients with chronic obstructive pulmonary disease (COPD).


METHODS
COPD patients and normal subjects were recruited from Beijing Hospital during March 2013 to March 2014. COPD patients were divided into COPD low risk and COPD high risk groups according to the criteria of Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy. The plasma concentrations of desmosine were measured by enzyme-linked immunosorbent assay (ELISA) for exploring the inter-group difference in desmosine levels.


RESULTS
Sixty-three COPD patients (COPD low risk group, n = 30; COPD high risk group, n = 33) and 50 normal subjects (24 healthy non-smokers, 26 healthy smokers) were recruited. The plasma desmosine concentrations in healthy non-smokers, healthy smokers, low risk and high risk COPD patients were (200 ± 159), (191 ± 105), (197 ± 118) and (131 ± 47) ng/L respectively. The plasma concentration of desmosine was significantly lower in COPD high risk group than healthy non-smokers (mean difference -70, 95%CI: -128--11, P = 0.021), healthy smokers (mean difference -60, 95%CI: -118--3, P = 0.039) and COPD low risk group (mean difference -67, 95%CI: -122--12, P = 0.018). The plasma concentration of desmosine was negatively correlated with exacerbation frequency (r = -0.409, P = 0.002), mMRC scores (r = -0.447, P = 0.010) and emphysema severity (r = -0.386, P = 0.047) in COPD patients. No significant correlation existed between desmosine plasma levels and forced expiratory volume in one second (FEV1%pred) in COPD patients (r = 0.225, P = 0.084).


CONCLUSIONS
The plasma levels of desmosine are lower in high risk COPD patients than those in normal subjects or low risk COPD patients. And it is negatively correlated with exacerbation frequency in COPD patients.
Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing 100730, China.
Yimeng
Y
Yang
Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing 100730, China.
Yanfei
Y
Guo
Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing 100730, China.
Hongsheng
H
Zhang
Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing 100730, China. Email: suntieying@126.com.
Tieying
T
Sun
D003895:Desmosine; D004797:Enzyme-Linked Immunosorbent Assay; D005541:Forced Expiratory Volume; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive; D011656:Pulmonary Emphysema; D018570:Risk Assessment; D012907:Smoking
D003895:Desmosine