The simultaneous occurrence of multiple myeloma and JAK2 positive myeloproliferative neoplasms - Report on two cases.
Multiple myeloma and JAK2 positive chronic myeloproliferative neoplasms are hematologic malignancies with a completely different cellular origin. Two cases of simultaneous occurrence of multiple myeloma, one with primary myelofibrosis and another one with essential thrombocythemia are reported in this article. In such cases, an accurate diagnosis requires a molecular testing, including gene sequencing and differential diagnosis of pancytosis associated with splenic amyloidosis. In general, in such cases, of two coexisting malignant hematologic diseases, the treatment of the most aggressive one is recommended. For our two cases, it was decided to start a Velcade based therapy. The main concern was the medullar toxicity, especially when a multiple myeloma was associated with a primary myelofibrosis.
Centre of Hematology and Bone Marrow Transplant, "Fundeni" Clinical Institute, Bucharest, Romania.
S
S
Badelita
Centre of Hematology and Bone Marrow Transplant, "Fundeni" Clinical Institute, Bucharest, Romania ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
C
C
Dobrea
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
A
A
Colita
Centre of Hematology and Bone Marrow Transplant, "Fundeni" Clinical Institute, Bucharest, Romania.
M
M
Dogaru
Centre of Hematology and Bone Marrow Transplant, "Fundeni" Clinical Institute, Bucharest, Romania.
M
M
Dragomir
Centre of Hematology and Bone Marrow Transplant, "Fundeni" Clinical Institute, Bucharest, Romania ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
C
C
Jardan
Centre of Hematology and Bone Marrow Transplant, "Fundeni" Clinical Institute, Bucharest, Romania ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
D
D
Coriu
D000368:Aged; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D003450:Cryoglobulins / Q000378:metabolism; D005260:Female; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics*; D009101:Multiple Myeloma / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D009196:Myeloproliferative Disorders / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology
D003450:Cryoglobulins; C507924:JAK2 protein, human; D053614:Janus Kinase 2
JAK2; essential thrombocythemia; multiple myeloma; primary myelofibrosis