INTRA-SCLERAL PARATHALAMUS IMPLANT: EFFICACY AND SAFETY IN RABBIT EYES.
OBJECTIVE
A variety of anti-glaucomatous shunt designs have been proposed so far. This study evaluates the feasibility of a novel shunt design, the intra-scleral parathalamus implant (IPI), in a rabbit eye model.


METHODS
Ten healthy albino rabbits were included. Measurements of the IOP, using TonoPenXL, as well as ocular rigidity (OR) and aqueous outflow facility (AO), using a previously described methodology, were performed in both eyes of each animal. Subsequently, the IPI was implanted at the left eye of all animals whereas the right eye served as control. Measurements of IOP were repeated at weekly intervals for 2 months postoperatively whereas measurements of OR and AO were repeated at the 1st and 2nd postoperative week.


RESULTS
The IOP decreased significantly whereas the AO increased significantly postoperatively at the operated eyes. A significant postoperative decrease in OR was also recorded at the operated eyes. Respective differences at the fellow eyes were statistically not significant. Two animals developed postoperative complications and were excluded from follow-up.


CONCLUSIONS
Results imply that the implantation of the IPI is feasible in rabbit eyes with significant favorable effects on the IOP, AO and OR.
Department of Ophthalmology, University Hospital of Heraklion, Greece. detorakis@hotmail.com.
Efstathios T
ET
Detorakis
Institute of Vision & Optics, University of Crete, Greece.
Konstantina
K
Loggaki
Institute of Vision & Optics, University of Crete, Greece.
Nikolaos
N
Karyotakis
Institute of Vision & Optics, University of Crete, Greece.
Harilaos
H
Ginis
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005901:Glaucoma / Q000601:surgery*; D007429:Intraocular Pressure; D019736:Prostheses and Implants; D011817:Rabbits; D012599:Sclerostomy / Q000379:methods*