Functional photostability and cutaneous compatibility of bioactive UVA sun care products.
Sunscreens are the most-established approach for photoprotection. The strategy of providing antioxidant properties to sun care products by addition of natural and potent anti-free radical compounds has led to the development of bioactive sunscreens, able to neutralize the harmful effects of ultraviolet (UV) radiation. UVA filters, such as benzophenone-3 (BP) and butyl methoxydibenzoylmethane (BMDBM), can exhibit photodegradation which limits the development of broad spectrum sunscreens. Previous research verified that rutin interacts with filters incorporated in sunscreens. In this work, we focused on the development and evaluation of the efficacy of the sunscreens containing either BP or BMDBM with and without rutin. The addition of rutin to the UVA filters afforded antioxidant properties to the formulations and they were considered safe for human use. Additionally, rutin in combination with either BP or BMDBM increased the antioxidant activity about 40 times when compared with the UVA filters alone. Remarkably, the addition of rutin 0.1% (w/w) to BP 6.0% (w/w) raised the SPF from 24.3±1.53 to 33.3±2.89. In conclusion, these findings demonstrated that the addition of rutin into sunscreens can markedly improve the antioxidant properties of the formulation as well as photostabilize some of the UVA filters.
Department of Pharmacy, University of São Paulo, 580 Prof. Lineu Prestes Av., Bl. 15, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil. Electronic address: milaareias@usp.br.
Camila Areias
CA
de Oliveira
Department of Pharmacy, University of São Paulo, 580 Prof. Lineu Prestes Av., Bl. 15, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil.
Daniela D Almeida
DDA
Peres
Department of Pharmacy, University of São Paulo, 580 Prof. Lineu Prestes Av., Bl. 15, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil.
Caynan Mendes
CM
Rugno
Department of Pharmacy, University of São Paulo, 580 Prof. Lineu Prestes Av., Bl. 15, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil.
Mayara
M
Kojima
Department of Pharmacy, University of São Paulo, 580 Prof. Lineu Prestes Av., Bl. 15, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil.
Claudinéia Aparecida Sales de Oliveira
CASO
Pinto
Department of Pharmacy, University of São Paulo, 580 Prof. Lineu Prestes Av., Bl. 15, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil.
Vladi Olga
VO
Consiglieri
Department of Pharmacy, University of São Paulo, 580 Prof. Lineu Prestes Av., Bl. 15, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil.
Telma Mary
TM
Kaneko
CBIOS-Research Center for Biosciences and Health Technologies, Lusófona University, Campo Grande 376, 1749-024 Lisbon, Portugal.
Catarina
C
Rosado
CBIOS-Research Center for Biosciences and Health Technologies, Lusófona University, Campo Grande 376, 1749-024 Lisbon, Portugal.
Joana
J
Mota
Department of Pharmacy, University of São Paulo, 580 Prof. Lineu Prestes Av., Bl. 15, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil.
Maria Valéria Robles
MVR
Velasco
Department of Pharmacy, University of São Paulo, 580 Prof. Lineu Prestes Av., Bl. 15, Conjunto das Químicas, Cidade Universitária, 05508-900 São Paulo, SP, Brazil.
André Rolim
AR
Baby
D000328:Adult; D000473:Alkanes / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry; D001577:Benzophenones / Q000737:chemistry; D047188:Chalcones / Q000737:chemistry; D004355:Drug Stability; D005260:Female; D006801:Humans; D008297:Male; D011427:Propiophenones; D012431:Rutin / Q000737:chemistry; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D013473:Sunscreening Agents / Q000737:chemistry / Q000494:pharmacology*; D014466:Ultraviolet Rays; D055815:Young Adult
D000473:Alkanes; D000975:Antioxidants; D001577:Benzophenones; D047188:Chalcones; D011427:Propiophenones; D013473:Sunscreening Agents; D012431:Rutin; C005290:oxybenzone; C049935:avobenzone