Development of a HIV-1 Virus Detection System Based on Nanotechnology.
Development of a sensitive and selective detection system for pathogenic viral agents is essential for medical healthcare from diagnostics to therapeutics. However, conventional detection systems are time consuming, resource-intensive and tedious to perform. Hence, the demand for sensitive and selective detection system for virus are highly increasing. To attain this aim, different aspects and techniques have been applied to develop virus sensor with improved sensitivity and selectivity. Here, among those aspects and techniques, this article reviews HIV virus particle detection systems incorporated with nanotechnology to enhance the sensitivity. This review mainly focused on four different detection system including vertically configured electrical detection based on scanning tunneling microscopy (STM), electrochemical detection based on direct electron transfer in virus, optical detection system based on localized surface plasmon resonance (LSPR) and surface enhanced Raman spectroscopy (SERS) using plasmonic nanoparticle.
Department of Chemical & Biomolecular Engineering, Sogang University, #1 Shinsu-Dong, Mapo-Gu, Seoul 121-742, Korea. jino@sogang.ac.kr.
Jin-Ho
JH
Lee
Department of Chemical & Biomolecular Engineering, Sogang University, #1 Shinsu-Dong, Mapo-Gu, Seoul 121-742, Korea. bkoh@sogang.ac.kr.
Byung-Keun
BK
Oh
Department of Chemical & Biomolecular Engineering, Sogang University, #1 Shinsu-Dong, Mapo-Gu, Seoul 121-742, Korea. jwchoi@sogang.ac.kr.
Jeong-Woo
JW
Choi
D015374:Biosensing Techniques / Q000379:methods*; D015497:HIV-1 / Q000302:isolation & purification*; D036103:Nanotechnology / Q000379:methods*; D013059:Spectrum Analysis, Raman; D020349:Surface Plasmon Resonance; D014771:Virion / Q000302:isolation & purification