Lupus nephritis management guidelines compared.
In the past years, many (randomized) trials have been performed comparing the treatment strategies for lupus nephritis. In 2012, these data were incorporated in six different guidelines for treating lupus nephritis. These guidelines are European, American and internationally based, with one separate guideline for children. They offer information on different aspects of the management of lupus nephritis including induction and maintenance treatment of the different histological classes, adjunctive treatment, monitoring of the patient, definitions of response and relapse, indications for (repeat) renal biopsy, and additional challenges such as the presence of vascular complications, the pregnant SLE patient, treatment in children and adolescents and considerations about end-stage renal disease and transplantation. In this review, we summarize the guidelines, determine the common ground between them, highlight the differences and discuss recent literature.
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Suzanne
S
Wilhelmus
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Ingeborg M
IM
Bajema
Rheumatology, Clinical Immunology and Allergy, Medical School, University of Crete, Iraklion, Greece Infections and Immunity Division, IMBB-FORTH, Iraklion, Greece.
George K
GK
Bertsias
Infections and Immunity Division, IMBB-FORTH, Iraklion, Greece Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Dimitrios T
DT
Boumpas
Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, The Medical School, University of Birmingham, Birmingham, UK.
Caroline
C
Gordon
Section of Renal Medicine and Vascular Inflammation, Department of Medicine, Imperial College London, London, UK.
Liz
L
Lightstone
Department of Nephrology, 1st School of Medicine, Charles University, Prague, Czech Republic.
Vladimir
V
Tesar
Addenbrooke's Hospital, Lupus and Vasculitis Unit, Cambridge, UK.
David R
DR
Jayne
D019468:Disease Management; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008181:Lupus Nephritis / Q000209:etiology / Q000628:therapy*; D017410:Practice Guidelines as Topic / Q000592:standards*
guideline; lupus nephritis; management; systemic lupus erythematosus; treatment