A quantitative approach for studying the bioactivity of nanohydroxyapatite/gold composites.
This work describes a quantitative kinetic approach to assess the in vitro bioactivity of gold-doped hydroxyapatite-polyvinyl alcohol nanocomposites. The surface morphology of the in situ prepared nanocomposites as characterized by transmission electron microscopy (TEM) revealed a rod-like shape. Differential thermal analysis-thermogravimetric (DTA-TG), and fourier transformed infrared spectroscopy (FTIR) as well as zeta potential measurements of the prepared nanocomposites were carried out. Uptake profiles of Ca and P were studied onto nanocomposites of different gold concentrations after their soaking in simulated body fluid and they best followed the pseudo second-order kinetic model. The highest uptakes of both Ca and P were obtained using the nanocomposite with the lowest concentration of gold. Furthermore, sorption mechanism was described by the intraparticle diffusion model where pore diffusion was found to be the rate limiting step. The prepared nanocomposites have promising potential in orthopedic and tissue engineering applications because of their high capacity and fast uptake for Ca and P, which form apatite.
Solid-State Chemistry, Université de Rennes 1, UMR CNRS 6226, 263 av. du général leclerc, 35042, Rennes Cedex, France.|Biomaterials Department, National Research Centre NRC, Cairo, Egypt.|Nanomedicine & Tissue Engineering Lab, Medical Research Center of Excellence (MRCE), NRC, Cairo, Egypt.
Amany A
AA
Mostafa
Solid-State Chemistry, Université de Rennes 1, UMR CNRS 6226, 263 av. du général leclerc, 35042, Rennes Cedex, France.
Hassane
H
Oudadesse
Nanomedicine & Tissue Engineering Lab, Medical Research Center of Excellence (MRCE), NRC, Cairo, Egypt.|Chemical Engineering Department, National Research Centre, Al Bohooth St., Cairo, Egypt.|Chemistry Department, American University in Cairo, New Cairo, Egypt.
Mayyada M H
MM
El-Sayed
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001672:Biocompatible Materials / Q000494:pharmacology*; D001826:Body Fluids / Q000187:drug effects; D002118:Calcium / Q000032:analysis; D004055:Differential Thermal Analysis; D017886:Durapatite / Q000494:pharmacology*; D006046:Gold / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010758:Phosphorus / Q000032:analysis; D011142:Polyvinyl Alcohol / Q000737:chemistry; D011205:Povidone / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013818:Thermogravimetry; D013997:Time Factors
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D010758:Phosphorus; D006046:Gold; D011142:Polyvinyl Alcohol; D017886:Durapatite; D011205:Povidone; D002118:Calcium
bioactivity; gold nanoparticles; hydroxyapatite; kinetics; nanocomposites