Primary atypical teratoid/rhabdoid tumor of the optic nerve: a rare entity in an exceptional location.
Atypical teratoid/rhabdoid tumors are rare and highly malignant central nervous system tumors. They have no specific radiological features and often present several histological components that make a problem in differential diagnosis with medulloblastoma and primitive neuroectodermal tumors. We present the case of a newborn girl complained of a gradual proptosis of the left eye secondary to an expansive lesional process of the optic nerve. The location at the optic nerve, reported only twice in the literature, and an exclusive rhabdoid appearance on biopsy added additional differential diagnosis problems. The proptosis worsened and the infant died few days after two cycles of chemotherapy.
The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2037718783145212 .
Department of Pathology, Specialities Hospital, Ibn Sina University Hospital, Rabat, Morocco. ysf.mahdi@gmail.com.|Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco. ysf.mahdi@gmail.com.
Youssef
Y
Mahdi
Department of Pathology, Specialities Hospital, Ibn Sina University Hospital, Rabat, Morocco. Jinane.kharmoum@gmail.com.|Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco. Jinane.kharmoum@gmail.com.
Jinane
J
Kharmoum
Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco. ophtalmo.09@gmail.com.|Department of Ophtamology, Specialities Hospital, Ibn Sina University Hospital, Rabat, Morocco. ophtalmo.09@gmail.com.
Amal
A
Alouan
Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco. hakima.med@gmail.com.|Department of Ophtamology, Specialities Hospital, Ibn Sina University Hospital, Rabat, Morocco. hakima.med@gmail.com.
Hakima
H
Elouarradi
Department of Pathology, Specialities Hospital, Ibn Sina University Hospital, Rabat, Morocco. iman.elkhiyat@gmail.com.|Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco. iman.elkhiyat@gmail.com.
Iman
I
Elkhiyat
Department of Pathology, Specialities Hospital, Ibn Sina University Hospital, Rabat, Morocco. mostafamaher1512@gmail.com.|Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco. mostafamaher1512@gmail.com.
Mustapha
M
Maher
Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco. mzbenchrif@hotmail.com.|Department of Ophtamology, Specialities Hospital, Ibn Sina University Hospital, Rabat, Morocco. mzbenchrif@hotmail.com.
Moulay Zahid
MZ
Benchrif
Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco. aminakili@yahoo.fr.|Pediatric Hematology and Oncology Center, Ibn Sina University Hospital, Rabat, Morocco. aminakili@yahoo.fr.
Amina
A
Kili
Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco. rdaoudi@hotmail.fr.|Department of Ophtamology, Specialities Hospital, Ibn Sina University Hospital, Rabat, Morocco. rdaoudi@hotmail.fr.
Rajae
R
Daoudi
Department of Pathology, Specialities Hospital, Ibn Sina University Hospital, Rabat, Morocco. ncherradi2013@gmail.com.|Faculty of Medicine and Pharmacy, Mohammed V Souissi University, Rabat, Morocco. ncherradi2013@gmail.com.
Nadia
N
Cherradi
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D019574:Optic Nerve Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D011237:Predictive Value of Tests; D018335:Rhabdoid Tumor / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D013724:Teratoma / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology*; D017211:Treatment Failure
D014408:Biomarkers, Tumor