Cross-talk in host-parasite associations: What do past and recent proteomics approaches tell us?
A cross-talk in host-parasite associations begins when a host encounters a parasite. For many host-parasite relationships, this cross-talk has been taking place for hundreds of millions of years. The co-evolution of hosts and parasites, the familiar 'arms race' results in fascinating adaptations. Over the years, host-parasite interactions have been studied extensively from both the host and parasitic point of view. Proteomics studies have led to new insights into host-parasite cross-talk and suggest that the molecular strategies used by parasites attacking animals and plants share many similarities. Likewise, animals and plants use several common molecular tactics to counter parasite attacks. Based on proteomics surveys undertaken since the post-genomic era, a synthesis is presented on the molecular strategies used by intra- and extracellular parasites to invade and create the needed habitat for growth inside the host, as well as strategies used by hosts to counter these parasite attacks. Pitfalls in deciphering host-parasite cross-talk are also discussed. To conclude, helpful advice is given with regard to new directions that are needed to discover the generic and specific molecular strategies used by the host against parasite invasion as well as by the parasite to invade, survive, and grow inside their hosts, and to finally discover parasitic molecular signatures associated with their development.
Université Blaise Pascal - Clermont-Ferrand II (UBP), Clermont Université, 34, Avenue Carnot, BP, 63006 Clermont-Ferrand Cedex, France; INRA, UMR1095 Génétique Développement et Ecophysiologie des Céréales, 5 chemin Beaulieu, F-63039 Clermont-Ferrand Cedex 2, France.
Chérif
C
Chetouhi
Université Blaise Pascal - Clermont-Ferrand II (UBP), Clermont Université, 34, Avenue Carnot, BP, 63006 Clermont-Ferrand Cedex, France; Microorganismes: Génome et Environnement (LMGE), CNRS: UMR6023, Université Blaise Pascal - Clermont-Ferrand II, Campus des Cézeaux, 24, Avenue des Landais, BP 80026, 63 171 Aubière Cedex, France; Université d'Auvergne - Clermont-Ferrand 1 (UDA), Clermont Université, 49, Boulevard François-Mitterrand, CS 60032, 63001 Clermont-Ferrand Cedex 1, France.
Johan
J
Panek
Université Blaise Pascal - Clermont-Ferrand II (UBP), Clermont Université, 34, Avenue Carnot, BP, 63006 Clermont-Ferrand Cedex, France; INRA, UMR1095 Génétique Développement et Ecophysiologie des Céréales, 5 chemin Beaulieu, F-63039 Clermont-Ferrand Cedex 2, France.
Ludovic
L
Bonhomme
Université Blaise Pascal - Clermont-Ferrand II (UBP), Clermont Université, 34, Avenue Carnot, BP, 63006 Clermont-Ferrand Cedex, France; Microorganismes: Génome et Environnement (LMGE), CNRS: UMR6023, Université Blaise Pascal - Clermont-Ferrand II, Campus des Cézeaux, 24, Avenue des Landais, BP 80026, 63 171 Aubière Cedex, France; Université d'Auvergne - Clermont-Ferrand 1 (UDA), Clermont Université, 49, Boulevard François-Mitterrand, CS 60032, 63001 Clermont-Ferrand Cedex 1, France.
Hicham
H
ElAlaoui
Université Blaise Pascal - Clermont-Ferrand II (UBP), Clermont Université, 34, Avenue Carnot, BP, 63006 Clermont-Ferrand Cedex, France; Microorganismes: Génome et Environnement (LMGE), CNRS: UMR6023, Université Blaise Pascal - Clermont-Ferrand II, Campus des Cézeaux, 24, Avenue des Landais, BP 80026, 63 171 Aubière Cedex, France; Université d'Auvergne - Clermont-Ferrand 1 (UDA), Clermont Université, 49, Boulevard François-Mitterrand, CS 60032, 63001 Clermont-Ferrand Cedex 1, France.
Catherine
C
Texier
Université Blaise Pascal - Clermont-Ferrand II (UBP), Clermont Université, 34, Avenue Carnot, BP, 63006 Clermont-Ferrand Cedex, France; INRA, UMR1095 Génétique Développement et Ecophysiologie des Céréales, 5 chemin Beaulieu, F-63039 Clermont-Ferrand Cedex 2, France.
Thierry
T
Langin
Department of Entomology and Department of Biology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, State College, 16802 PA, United States.
Charissa
C
de Bekker
Functional Proteomics Platform - FPP, UMR CNRS 5203, IGF, 141 rue de la Cardonille, F-34 094 Montpellier Cedex 5, France.
Serge
S
Urbach
Functional Proteomics Platform - FPP, UMS CNRS 3426, IGF, 141 rue de la Cardonille, F-34 094 Montpellier Cedex 5, France.
Edith
E
Demettre
Laboratoire MIVEGEC, UMR CNRS 5290/IRD 224/UM, 911 Avenue Agropolis, BP 64501, 34394 Montpellier Cedex 5, France.
Dorothée
D
Missé
UMR 15 CIRAD-INRA CMAEE "Contrôle des maladies animales exotiques et émergentes", TA A-15/G Campus international de Baillarguet, 34398 Montpellier Cedex 5, France.
Philippe
P
Holzmuller
Department of Entomology and Department of Biology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, State College, 16802 PA, United States.
David P
DP
Hughes
INSERM, UMR1090 TAGC, Marseille, France; Aix-Marseille Université, UMR1090 TAGC, Marseille, France.
Andreas
A
Zanzoni
INSERM, UMR1090 TAGC, Marseille, France; Aix-Marseille Université, UMR1090 TAGC, Marseille, France; CNRS, Marseille, France.
Christine
C
Brun
Université Blaise Pascal - Clermont-Ferrand II (UBP), Clermont Université, 34, Avenue Carnot, BP, 63006 Clermont-Ferrand Cedex, France; Microorganismes: Génome et Environnement (LMGE), CNRS: UMR6023, Université Blaise Pascal - Clermont-Ferrand II, Campus des Cézeaux, 24, Avenue des Landais, BP 80026, 63 171 Aubière Cedex, France; Université d'Auvergne - Clermont-Ferrand 1 (UDA), Clermont Université, 49, Boulevard François-Mitterrand, CS 60032, 63001 Clermont-Ferrand Cedex 1, France. Electronic address: david.biron1@univ-bpclermont.fr.
David G
DG
Biron
D000818:Animals; D006790:Host-Parasite Interactions; D006801:Humans; D010271:Parasites / Q000502:physiology*; D040901:Proteomics / Q000379:methods
Host invasion; Host–parasite cross-talk; Parasite strategies; Parasitism; Quantitative proteomics