Therapeutic potential of cancer stem cells.
Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer's relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.
Department of Otorhinolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chunguang
C
Yang
Kunlin
K
Jin
Yangping
Y
Tong
William Chi
WC
Cho
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D003933:Diagnosis; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology
D014408:Biomarkers, Tumor