Advances in genetics and genomics: use and limitations in achieving malaria elimination goals.
Success of the global research agenda towards eradication of malaria will depend on the development of new tools, including drugs, vaccines, insecticides and diagnostics. Genetic and genomic information now available for the malaria parasites, their mosquito vectors and human host, can be harnessed to both develop these tools and monitor their effectiveness. Here we review and provide specific examples of current technological advances and how these genetic and genomic tools have increased our knowledge of host, parasite and vector biology in relation to malaria elimination and in turn enhanced the potential to reach that goal. We then discuss limitations of these tools and future prospects for the successful achievement of global malaria elimination goals.
Sharmini
S
Gunawardena
Nadira D
ND
Karunaweera
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D000962:Antimalarials / Q000008:administration & dosage*; D060740:Disease Eradication / Q000639:trends*; D055808:Drug Discovery; D023281:Genomics; D006040:Goals; D006790:Host-Parasite Interactions; D006801:Humans; D007303:Insect Vectors; D007306:Insecticides; D008288:Malaria / Q000517:prevention & control* / Q000635:transmission; D017780:Malaria Vaccines; D009032:Mosquito Control
D000962:Antimalarials; D007306:Insecticides; D017780:Malaria Vaccines
Eradication,; Genetic diversity,; Infectious disease,; Malaria control; Parasitic disease,; Plasmodium,; Vaccines,