Rare adverse effect of a common drug: nitrofurantoin-induced ANCA-associated vasculitis.
Nitrofurantoin is commonly prescribed to treat urinary tract infections (UTI). Reported adverse effects include gastrointestinal, pulmonary, hepatic and neurological disorders. We report a case of a 67-year-old woman treated for UTI with nitrofurantoin who presented with antineutrophilic cytoplasmic antibody (ANCA)-associated renal and skin vasculitis 3 days after starting treatment. The symptoms resolved following withdrawal of the drug and treatment with steroids. This is the first reported case of nitrofurantoin causing ANCA-associated vasculitis.
Cooper University Hospital, Philadelphia, Pennsylvania, USA.
Abhishek
A
Agarwal
Department of Internal Medicine, Monmouth Medical Center, Long Branch, New Jersey, USA.
Abhinav
http://orcid.org/0000-0003-1080-6449
A
Agrawal
Department of Internal Medicine, Cooper University Hospital, Camden, New Jersey, USA.
Karim
K
Nathan
Department of Internal Medicine, Cooper University Hospital, Camden, New Jersey, USA.
Satyajeet
S
Roy
D000368:Aged; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000009:adverse effects*; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000378:metabolism*; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000009:adverse effects*; D011693:Purpura / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000892:Anti-Infective Agents, Urinary; D019268:Antibodies, Antineutrophil Cytoplasmic; D009582:Nitrofurantoin