Unusual 2(1H)-pyrazinones isolated from a culture of a Brazilian marine-derived Streptomyces sp.
Four new secondary metabolites, giovaninones A-D (1-4), were isolated from an ethyl acetate extract of a culture of a marine-derived Streptomyces strain designated SS99BA-2. Chemical analysis was completely conducted in a coupled automated LC-SPE system with the use of a cryogenic NMR probehead and HRMS. The application of this system to identify, purify and elucidate all the structures is described.
Sergio S
SS
Thomasi
Ana C
AC
Granato
Luis H
LH
Romano
Liene
L
Dhooghe
Eduardo S P
ES
do Nascimento
Alberto C
AC
Badino
Maria F G F
MF
da Silva
Antonio G
AG
Ferreira
Tiago
T
Venâncio
D001938:Brazil; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011719:Pyrazines / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D012623:Seawater / Q000382:microbiology*; D064210:Secondary Metabolism; D013302:Streptomyces / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*
D011719:Pyrazines