A lactone-fused cyclohexadiene as a versatile platform for diversified synthesis of 5,6,5-tricyclic scaffolds.
A lactone-fused cyclohexadiene, which can be readily prepared by ruthenium(III)-catalyzed [2 + 2 + 2] cyclization of an enediyne, functioned as a versatile platform for the stereoselective synthesis of differently functionalized 5,6,5-tricyclic scaffolds.
Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan. yamamoto-yoshi@ps.nagoya-u.ac.jp m-shibu@ps.nagoya-u.ac.jp.
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Shibuya
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Sudoh
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Kawamura
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Yamamoto
D002384:Catalysis; D003500:Cyclization; D053138:Cyclohexenes / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism
D053138:Cyclohexenes; D007783:Lactones; C048401:1,4-cyclohexadiene; D012428:Ruthenium