Brain development in male rats subjected to early weaning and treated with diet containing flour or flaxseed oil after 21 days until 60 days.
The precocious interruption of lactation is a prime factor for developmental plasticity. Here we analyzed whether flour or flaxseed oil treatment contributes to body and brain mass in male rats subjected to early weaning. Pups were weaned for separation from their mother at 14 (early weaning, EW) and 21 days (control, C). At 21 days, some of the pups were evaluated (C21 v. EW21). After 21 days, control pups (C60) were fed a control diet. EW pups were divided into those fed a control diet (EWC60), those given flaxseed flour (EWFF60), and those given flaxseed oil (EWFO60) until 60 days. EW21 showed lower body and absolute brain mass and higher relative brain mass. At 60 days, EWC60 and EWFO60 had lower body mass. With regard to relative brain mass, EWC60 was heavier; EWFO60 had lower values compared with EWC60 and higher values compared with C60 and EWFF60. These results indicated that flaxseed flour, in comparison with flaxseed oil, contributes to brain development after EW.
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
C R
CR
Pessanha
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
B Ferolla
BF
da Camara Boueri
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
L Rodrigues
LR
da Costa
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
M Rocha
MR
Ferreira
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
H Saldanha
HS
Melo
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
M Duque Coutinho
MD
de Abreu
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
L Rozeno
LR
Pessoa
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
P C Alves
PC
da Silva
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
A D'Avila
AD
Pereira
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
D Cavalcante
DC
Ribeiro
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
J Azevedo
JA
de Meneses
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
C A Soares
CA
da Costa
Experimental Nutrition Laboratory,College of Nutrition,Federal Fluminense University,Niterói,Rio de Janeiro,Brazil.
G T
GT
Boaventura
D000818:Animals; D001921:Brain / Q000254:growth & development*; D005228:Fatty Acids, Essential; D019597:Flax; D008043:Linseed Oil; D008297:Male; D017208:Rats, Wistar; D014886:Weaning
D005228:Fatty Acids, Essential; D008043:Linseed Oil
brain; early weaning; flaxseed; rat