Mononuclear nonheme iron(III) complexes that show superoxide dismutase-like activity and antioxidant effects against menadione-mediated oxidative stress.
This communication describes the superoxide dismutase (SOD)-like activity of mononuclear iron(III) complexes with pentadentate monocarboxylamido ligands. The SOD activity can be controlled by the electronic nature of the substituent group on the ligand. The nitro-substituted complex showed clear cytoprotective activity against menadione-mediated oxidative stress in cultured cells.
Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyakodani, Tatara, 610-0321 Kyotanabe, Japan. yhitomi@mail.doshisha.ac.jp.
Yutaka
Y
Hitomi
Yuji
Y
Iwamoto
Akihiro
A
Kashida
Masahito
M
Kodera
D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005290:Ferric Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000737:chemistry* / Q000378:metabolism; D014407:Tumor Cells, Cultured; D024483:Vitamin K 3 / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
D000975:Antioxidants; D005290:Ferric Compounds; D008024:Ligands; D024483:Vitamin K 3; D013482:Superoxide Dismutase