Association of C5aR1genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.
BACKGROUND
Complement 5a receptor (C5aR) was demonstrated a receptor of complement 5a (C5a) which is involved in many inflammatory diseases. The functional responses attributed to C5a results from its interaction with its receptors C5aR, which stimulates food intake, plays a role in increasing the inflammatory response in adipose tissue as well as the cardiovascular and neural systems. However, There are unknown associations between the SNPs of C5aR1 gene and coronary artery disease (CAD).


METHODS
We examined the role of the tagging single nucleotide polymorphisms (SNPs) of C5aR1 gene for CAD using a case-control design, and determined the prevalence of C5aR1 genotypes in 505 CAD patients and 469 age and sex-matched healthy control subjects of Han population.


RESULTS
The rs10853784 was found to be associated with CAD in dominant model (CC vs TT + CT, P = 0.004). The difference remained statistically significant after multivariate adjustment (OR = 1.430, 95% CI: 1.087 ~ 1.882, P = 0.011). There was no significant difference in genotype distributions of rs4577202 and rs7250152 between CAD patients and control subjects. The frequency of the haplotype (A-T-C) was significantly higher in the CAD patients than in the controls (P = 0.035), and the haplotype (A-C-T) was significantly lower in the CAD patients than in the control subjects in Chinese Han population (P = 0.002).


CONCLUSIONS
The results of this study indicate that rs10853784 of C5aR1 gene are associated with CAD in Han population of China, and A-C-T haplotypes may be protective genetic marker and the A-T-C may be risk genetic marker for CAD in Chinese Han population.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2054871241495194 .
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R., China. zhengying527@163.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China. zhengying527@163.com.
Ying-Ying
YY
Zheng
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R., China. xiangxie999@sina.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China. xiangxie999@sina.com.
Xiang
X
Xie
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R., China. myt_xj@sina.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China. myt_xj@sina.com.
Yi-Tong
YT
Ma
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R., China. yangyn5126@163.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China. yangyn5126@163.com.
Yi-Ning
YN
Yang
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R., China. fuzhenyan@126.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China. fuzhenyan@126.com.
Zhen-Yan
ZY
Fu
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R., China. lixm505@163.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China. lixm505@163.com.
Xiao-Mei
XM
Li
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R., China. panshuoso@yeah.net.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China. panshuoso@yeah.net.
Shuo
S
Pan
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P.R., China. dailareadi@163.com.|Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China. dailareadi@163.com.
Dilare
D
Adi
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China. chenbangdang@126.com.
Bang-Dang
BD
Chen
Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, 830054, P.R., China. liufen82@gmail.com.
Fen
F
Liu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D002681:China; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044087:Receptor, Anaphylatoxin C5a / Q000235:genetics*
C488033:C5AR1 protein, human; D044087:Receptor, Anaphylatoxin C5a