A NCS mediated oxidative C-H bond functionalization: direct esterification between a C(sp(3))-H bond and carboxylic acids.
A transition metal free oxidative C-H bond functionalization/esterification of α-alkoxy alkanes with acids is described in this report. This method is effectively mediated by NCS instead of traditional oxidants, like TBHP or its derivatives, and directly generates the esterification products in moderate to high yield under mild conditions. This tranformation constitutes a practical and general approach toward various α-acyloxy ethers with broad substrate generality; alkyl-, aryl-, alkenyl- and alkynyl-carboxylic acids are all well tolerated.
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China. xinfangxu@suda.edu.cn.
Yang
Y
Zheng
Jincheng
J
Mao
Guangwei
G
Rong
Xinfang
X
Xu