Borderline resectable pancreatic cancer.
Borderline resectable pancreatic cancer (BRPC) is an evolving diagnostic entity that blurs the distinction between resectable and locally advanced pancreatic cancer (Varadhachary et al. Ann Surg Oncol 13:1035-1046, 2006). Until recently the management of this disease has been poorly defined; however, consensus guidelines have been developed regarding the proper management of this diagnostic entity. Recent studies have shown that if appropriately identified and treated, this subset of disease can have outcomes similar to pancreatic cancer that is defined as resectable (Laurence et al. J Gastrointest Surg 15:2059-2069, 2011). The aim of this review is to outline the current consensus on definitions, workup and management of BRPC, and also provide a summary of issues that require progress as defined by the International Study Group of Pancreatic Surgery (ISGPS).
Department of Surgery, University of Nebraska Medical Center, Omaha, NE USA.
Bhargava
B
Mullapudi
Department of Surgery, University of Nebraska Medical Center, Omaha, NE USA.
Patrick J
PJ
Hawkes
Department of Surgery, University of Nebraska Medical Center, Omaha, NE USA.
Asish
A
Patel
Department of Surgery, University of Nebraska Medical Center, Omaha, NE USA.
Chandrakanth
C
Are
Department of Surgery, Texas Tech University Health Sciences Center, 1400 S Coulter St, Amarillo, TX 79106 USA.
Subhasis
S
Misra
Borderline; Pancreas; Pancreatic cancer; Pancreaticoduodenectomy; Whipple