New naphthoquinone derivatives against glioma cells.
This work was aimed to the development of a set of new naphtoquinone derivatives that can act against glioma. The compounds were tested in order to find out their ability to inhibit the growth of glioma cells, and the results of these assays were correlated with electrochemical analysis and NMR-based reoxidation kinetic studies, suggesting that a redox mechanism underlies and may explain the observed biological behavior. In addition to a full description of the synthetic pathways, electrochemistry, NMR and single crystal X-ray diffraction data are provided.
Department of Molecular Medicine, University of Padova, Via Marzolo 3, 35131 Padova, Italy.
Marco
M
Redaelli
Department of Molecular Medicine, University of Padova, Via Marzolo 3, 35131 Padova, Italy.
Carla
C
Mucignat-Caretta
Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy.
Abdirisak Ahmed
AA
Isse
Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy.
Armando
A
Gennaro
Department of Medical and Surgical Sciences-Operative Unit of Endocrinology, University of Padova, Via Ospedale 105, 35128 Padova, Italy.
Raffaele
R
Pezzani
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.
Riccardo
R
Pasquale
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.
Valeria
V
Pavan
Institute of Biomolecular Chemistry, Padova Unit, CNR, Via Marzolo 1, 35131 Padova, Italy.
Marco
M
Crisma
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.
Giovanni
G
Ribaudo
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy. Electronic address: giuseppe.zagotto@unipd.it.
Giuseppe
G
Zagotto
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009285:Naphthoquinones
Glioma; Naphtoquinones; Redox; Temozolomide