Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury.
In the mature mammalian brain, new neurons are generated throughout life in the neurogenic regions of the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus. Over the past two decades, extensive studies have examined the extent of adult neurogenesis in the SVZ and DG, the role of the adult generated new neurons in normal brain function and the underlying mechanisms regulating the process of adult neurogenesis. The extent and the function of adult neurogenesis under neuropathological conditions have also been explored in varying types of disease models in animals. Increasing evidence has indicated that these endogenous neural stem/progenitor cells may play regenerative and reparative roles in response to CNS injuries or diseases. This review will discuss the potential functions of adult neurogenesis in the injured brain and will describe the recent development of strategies aimed at harnessing this neurogenic capacity in order to repopulate and repair the injured brain following trauma.
Department of Neurosurgery, Virginia Commonwealth University, P.O. Box 980631, Medical College of Virginia Campus, Richmond, VA 23298-631, USA. Electronic address: dsun@vcu.edu.
Dong
D
Sun
D000818:Animals; D001921:Brain / Q000166:cytology / Q000473:pathology* / Q000502:physiology; D001930:Brain Injuries / Q000473:pathology*; D006801:Humans; D058953:Neural Stem Cells / Q000473:pathology* / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D009474:Neurons / Q000473:pathology* / Q000502:physiology
Cognitive function; Endogenous neurogenesis; Hippocampus; Subventricular zone; Traumatic brain injury