Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study.
Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug treatment combined with CIAT (weeks 16-18), and then memantine/placebo alone (weeks 18-20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16-18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18-20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials.
Universidad de Málaga, Andalucía TECH-IBIMA, Unidad de Neurofisiología Cognitiva, Centro de Investigaciones Médico-Sanitarias (CIMES), Marqués de Beccaria, 3, 29010 Málaga, Spain.
Miguel A
MA
Barbancho
Universidad de Málaga, Andalucía TECH-IBIMA, Unidad de Afasia y Neurología Cognitiva, Centro de Investigaciones Médico-Sanitarias (CIMES) y Cátedra Fundación Morera y Vallejo de Afasia, Marqués de Beccaria, 3, 29010 Málaga, Spain.
Marcelo L
ML
Berthier
Universidad de Málaga, Andalucía TECH-IBIMA, Unidad de Neurofisiología Cognitiva, Centro de Investigaciones Médico-Sanitarias (CIMES), Marqués de Beccaria, 3, 29010 Málaga, Spain.
Patricia
P
Navas-Sánchez
Universidad de Málaga, Andalucía TECH-IBIMA, Unidad de Afasia y Neurología Cognitiva, Centro de Investigaciones Médico-Sanitarias (CIMES) y Cátedra Fundación Morera y Vallejo de Afasia, Marqués de Beccaria, 3, 29010 Málaga, Spain.
Guadalupe
G
Dávila
Departamento de Neurociencia, Hospital Quirón, Av. Imperio Argentina, 1, 29004 Málaga, Spain.
Cristina
C
Green-Heredia
Instituto Andaluz de Neurociencia y Conducta, Álamos 17, 29010 Málaga, Spain.
José M
JM
García-Alberca
Universidad de Málaga, Andalucía TECH-IBIMA, Unidad de Neurofisiología Cognitiva, Centro de Investigaciones Médico-Sanitarias (CIMES), Marqués de Beccaria, 3, 29010 Málaga, Spain.
Rafael
R
Ruiz-Cruces
Universidad de Málaga, Andalucía TECH-IBIMA, Unidad de Neurofisiología Cognitiva, Centro de Investigaciones Médico-Sanitarias (CIMES), Marqués de Beccaria, 3, 29010 Málaga, Spain.
Manuel V
MV
López-González
Universidad de Málaga, Andalucía TECH-IBIMA, Unidad de Neurofisiología Cognitiva, Centro de Investigaciones Médico-Sanitarias (CIMES), Marqués de Beccaria, 3, 29010 Málaga, Spain.
Marc S
MS
Dawid-Milner
Brain Language Laboratory, Freie Universität Berlin, Germany; Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, United Kingdom.
Friedemann
F
Pulvermüller
Universidad de Málaga, Andalucía TECH-IBIMA, Unidad de Neurofisiología Cognitiva, Centro de Investigaciones Médico-Sanitarias (CIMES), Marqués de Beccaria, 3, 29010 Málaga, Spain. Electronic address: jplara@uma.es.
J Pablo
JP
Lara
D000328:Adult; D000368:Aged; D001037:Aphasia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004311:Double-Blind Method; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007808:Language Therapy / Q000379:methods*; D008297:Male; D008559:Memantine / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011932:Reading; D020521:Stroke / Q000150:complications / Q000503:physiopathology / Q000628:therapy*
D008559:Memantine
Aphasia recovery; Constraint-induced aphasia therapy; Event-related potentials; Memantine; Stroke