Demographic, Hematologic, and Clinical Features of Myelodysplastic Syndrome Patients: Results from the First Polish Myelodysplastic Syndrome Registry.
Epidemiological studies on myelodysplastic syndromes (MDS) in Middle-Eastern Europe are scarce. No data about the demographic, clinical, and laboratory features of Polish MDS patients have been published. The aim of this study was to assess the epidemiological data and toxic exposure of Polish MDS patients and their association with hematological parameters and clinical outcomes. For 15 months, 966 living MDS patients were enrolled at 24 centers (12 university and 12 community hospitals). Follow-up was conducted for the next 55 months. The percentage of patients older than 80 years (16%) was between the values for Eastern and Western countries. In patients younger than 55 years, a female predominance was observed (male/female ratio 0.70:1 vs. 1.29:1; p < 0.001). Female patients had higher platelet counts (160 × 10⁹/l vs. 111 × 10⁹/l; p < 0.001). Patients exposed to chemicals were younger than patients without such exposure; their median age at MDS diagnosis was 66 vs. 70 years (p = 0.037). Smokers had significantly lower hemoglobin concentrations (8.6 vs. 9.1 g/dl; p = 0.032) and lower platelet counts (99 × 10⁹/l vs. 137 × 10⁹/l; p < 0.001) than nonsmokers. We provide the first description of the characteristics of Polish MDS patients. Females predominated in the group aged <60 years and they had higher platelet counts. The course of the disease is affected by toxic exposure and smoking.
Department of Hematology, Oncology, Internal Medicine and Bone Marrow Transplantation, Medical University of Warsaw, Warsaw, Poland.
Krzysztof
K
Mądry
Rafał
R
Machowicz
Anna
A
Waszczuk-Gajda
Joanna
J
Drozd-Sokołowska
Beata Stella
BS
Hołowiecka
Elżbieta
E
Wiater
Andrzej
A
Mital
Agata
A
Obara
Anna
A
Szmigielska-Kapłon
Agnieszka
A
Kołkowska-Leśniak
Anna
A
Sikorska
Edyta
E
Subocz
Włodzimierz
W
Mendrek
Magdalena
M
Szczepańska
Monika
M
Biedroń
Anna
A
Jachalska
Ewa
E
Wasilewska
Małgorzata
M
Wojciechowska
Renata
R
Guzicka-Kazimierczak
Agnieszka
A
Kopacz
Katarzyna
K
Katinas
Witold
W
Kruger
Anna
A
Dawidowska
Zoriana
Z
Salamańczuk
Daria
D
Zawirska
Alina
A
Świderska
Wiesław Wiktor
WW
Jędrzejczak
Jadwiga
J
Dwilewicz-Trojaczek
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006764:Hospitals, Community; D006785:Hospitals, University; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D011044:Poland / Q000453:epidemiology; D012042:Registries; D012189:Retrospective Studies; D012306:Risk; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000209:etiology*; D055815:Young Adult