Adult-born dentate neurons are recruited in both spatial memory encoding and retrieval.
Adult neurogenesis occurs in the dentate gyrus (DG) of the hippocampus, which is a key structure in learning and memory. Adult-generated granule cells have been shown to play a role in spatial memory processes such as acquisition or retrieval, in particular during an immature stage when they exhibit a period of increased plasticity. Here, we demonstrate that immature and mature neurons born in the DG of adult rats are similarly activated in spatial memory processes. By imaging the activation of these two different neuron generations in the same rat and by using the immediate early gene Zif268, we show that these neurons are involved in both spatial memory acquisition and retrieval. These results demonstrate that adult-generated granule cells are involved in memory beyond their immaturity stage.
Neurocentre MagendiePhysiopathologie De La Plasticité NeuronaleUnité 862, Institut National De La Santé Et De La Recherche Médicale, Inserm U862, Bordeaux-F33077, Paris, France.|Université Bordeaux, Bordeaux-F33000, France.
Sophie
S
Tronel
Neurocentre MagendiePhysiopathologie De La Plasticité NeuronaleUnité 862, Institut National De La Santé Et De La Recherche Médicale, Inserm U862, Bordeaux-F33077, Paris, France.|Université Bordeaux, Bordeaux-F33000, France.
Vanessa
V
Charrier
Neurocentre MagendiePhysiopathologie De La Plasticité NeuronaleUnité 862, Institut National De La Santé Et De La Recherche Médicale, Inserm U862, Bordeaux-F33077, Paris, France.|Université Bordeaux, Bordeaux-F33000, France.
Cyrille
C
Sage
Neurocentre MagendiePhysiopathologie De La Plasticité NeuronaleUnité 862, Institut National De La Santé Et De La Recherche Médicale, Inserm U862, Bordeaux-F33077, Paris, France.|Université Bordeaux, Bordeaux-F33000, France.
Marlene
M
Maitre
Neurocentre MagendiePhysiopathologie De La Plasticité NeuronaleUnité 862, Institut National De La Santé Et De La Recherche Médicale, Inserm U862, Bordeaux-F33077, Paris, France.|Université Bordeaux, Bordeaux-F33000, France.
Thierry
T
Leste-Lasserre
Neurocentre MagendiePhysiopathologie De La Plasticité NeuronaleUnité 862, Institut National De La Santé Et De La Recherche Médicale, Inserm U862, Bordeaux-F33077, Paris, France.|Université Bordeaux, Bordeaux-F33000, France.
Djoher N
DN
Abrous
D000367:Age Factors; D000818:Animals; D018891:Dentate Gyrus / Q000166:cytology / Q000502:physiology*; D051766:Early Growth Response Protein 1 / Q000235:genetics; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D065852:Spatial Memory / Q000502:physiology*
D051766:Early Growth Response Protein 1
adult neurogenesis; hippocampus; memory; rat; water maze