Methoxy poly(ethylene glycol) conjugated doxorubicin micelles for effective killing of cancer cells.
Methoxy poly(ethylene glycol) conjugated doxorubicin (mPEG-DOX) micelles are prepared for delivering drug effectively. The core of the unimolecular micelle is a DOX (doxorubicin) which is an anti-cancer chemotherapy drug, while the outer hydrophilic shell is composed of poly(ethylene glycol) (PEG) segments. Dynamic light scattering (DLS) analysis shows that the unimolecular micelles are uniform with a mean hydrodynamic diameter around 250 nm. The mPEG-DOX micelles can be internalized by the cancer cells and exhibit good cell uptake by the fluorescence microscopy. Obvious cytotoxicity is also observed when the concentration (count on DOX) is over 1 μg/mL. These findings indicate that these unique unimolecular micelles may offer a very promising approach for targeted cancer therapy.
Liming
L
Zhang
Kai
K
Xia
Yan
Y
Deng
Song
S
Li
Chuanxiang
C
Zhang
Zhuoxuan
Z
Lu
Nongyue
N
He
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry*; D016466:CHO Cells; D045744:Cell Line, Tumor; D003412:Cricetulus; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D011092:Polyethylene Glycols / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D008823:Micelles; D011092:Polyethylene Glycols; D004317:Doxorubicin