Chemical approach for target-selective degradation of oligosaccharides using photoactivatable organic molecules.
Molecular design, chemical synthesis, and biological evaluation of several organic molecules, which can target-selectively photodegrade oligosaccharides by irradiation with a specific wavelength of light under mild conditions without any additives, are introduced. These novel class of photochemical agents promise bright prospects for finding not only molecular-targeted bioprobes for understanding of the structure-activity relationships of oligosaccharides but also novel therapeutic drugs targeting biologically important oligosaccharides.
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan. toshima@applc.keio.ac.jp.
Kazunobu
K
Toshima
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.
Daisuke
D
Takahashi
D000873:Anthracenes / Q000737:chemistry / Q000378:metabolism*; D000880:Anthraquinones / Q000737:chemistry / Q000378:metabolism; D001897:Boronic Acids / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D010782:Photolysis; D013329:Structure-Activity Relationship
D000873:Anthracenes; D000880:Anthraquinones; D001897:Boronic Acids; D037102:Lectins; D009844:Oligosaccharides; C034020:anthracene
Anthracene; Anthraquinone; Boronic acid; Kemp’s acid; Lectin; Photodegradation