Gangliosides: glycosphingolipids essential for normal neural development and function.
Lipid rafts, sites of signal transduction, are enriched in glycosphingolipids (GSLs). Gangliosides, a class of GSLs found in greatest concentration in the grey matter of the brain, can affect neuronal function by modulating cell signaling. This review summarizes changes in ganglioside expression during brain development, the specific effects they induce, and makes observations about their possible role(s) in dementing diseases. Given that the average lifespan of individuals in many countries has increased, and that aging is accompanied by an increasing probability of dementia, understanding how changes in the GSL composition of lipid rafts may contribute to the cell biological basis of a specific dementing phenotype is an important area of study.
Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. Electronic address: cxs8@psu.edu.
Cara-Lynne
CL
Schengrund
D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000473:pathology; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002454:Cell Differentiation; D005732:Gangliosides / Q000502:physiology*; D019276:Glycocalyx / Q000378:metabolism; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism; D008969:Molecular Sequence Data; D019636:Neurodegenerative Diseases / Q000378:metabolism; D015398:Signal Transduction
D005732:Gangliosides
dementia; gangliosides; lipid rafts; neural development; signal transduction