Is antibiotic prophylaxis beneficial in acute pancreatitis?--First update.
This Living FRISBEE (Living FRIendly Summary of the Body of Evidence using Epistemonikos) is an update of the summary published in August 2014, based on two systematic reviews appeared in January and February 2015. There is controversy about the effects of prophylactic antibiotics in acute pancreatitis. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified 18 systematic reviews including 19 randomised studies overall. We combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach. We concluded that prophylactic antibiotics may reduce mortality and length of hospitalization in patients with acute pancreatitis, but the certainty of the evidence is low. The probability that future evidence change what we know is high.
Programa de Salud Basada en Evidencia, Facultad de Medicina, Pontificia Universidad Católica de Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile; GRADE working group; The Cochrane Collaboration; Fundación Epistemonikos. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile Lira 63, Santiago Centro, Chile. Email: radagabriel@epistemonikos.org.
Gabriel
G
Rada
Programa de Salud Basada en Evidencia, Facultad de Medicina, Pontificia Universidad Católica de Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile; Fundación Epistemonikos.
José
J
Peña
D000208:Acute Disease; D019072:Antibiotic Prophylaxis / Q000379:methods*; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007902:Length of Stay; D010195:Pancreatitis / Q000188:drug therapy* / Q000401:mortality; D016032:Randomized Controlled Trials as Topic