Outcomes of curettage and anhydrous alcohol adjuvant for low-grade chondrosarcoma of long bone.
BACKGROUND
Low-grade chondrosarcoma of long bones can be treated successfully with extended intralesional curettage using adjuvants. However, there is no study reporting the use of anhydrous alcohol as an adjuvant in the treatment of low-grade chondrosarcoma. We asked (1) whether intralesional curettage and anhydrous alcohol adjuvant for low-grade chondrosarcoma is associated with good oncologic outcomes; and we report (2) the complications of the procedure.


METHODS
Thirty-six patients (13 men, 23 women) with a mean age of 46 years (range, 18-67 years) were treated for low-grade chondrosarcoma and followed up for a median of 62 months (range, 24-169 months). After intralesional curettage, and additional burring, anhydrous alcohol was used as an adjuvant therapy.


RESULTS
At the time of last follow-up, there were no local recurrences or distant metastases. Six patients developed complications: 4 postoperative fractures (11%), 1 intra-articular loose body (3%) and 1 postoperative joint stiffness (3%).


CONCLUSIONS
Anhydrous alcohol is a reasonable adjuvant for the curettage of low-grade chondrosarcoma of long bones. A long-term follow-up study is necessary, considering the slow biological progression of low-grade chondrosarcoma.
Department of Orthopaedic Surgery, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, Seoul 110-744, South Korea. Electronic address: kalhonaaho@naver.com.
Wanlim
W
Kim
Department of Orthopaedic Surgery, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, Seoul 110-744, South Korea; Musculoskeletal Tumor Center, Seoul National University Cancer Hospital, 101 Daehak-ro Jongno-gu, Seoul 110-744, South Korea. Electronic address: hik19@snu.ac.kr.
Ilkyu
I
Han
Department of Orthopaedic Surgery, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, Seoul 110-744, South Korea. Electronic address: jean2can@hanmail.net.
Eo Jin
EJ
Kim
Department of Orthopaedic Surgery, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, Seoul 110-744, South Korea. Electronic address: ziozio79@daum.net.
Seungcheol
S
Kang
Department of Orthopaedic Surgery, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, Seoul 110-744, South Korea; Musculoskeletal Tumor Center, Seoul National University Cancer Hospital, 101 Daehak-ro Jongno-gu, Seoul 110-744, South Korea. Electronic address: hankim@snu.ac.kr.
Han-Soo
HS
Kim
D000293:Adolescent; D000328:Adult; D000368:Aged; D000438:Alcohols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002813:Chondrosarcoma / Q000601:surgery*; D003475:Curettage / Q000379:methods*; D005260:Female; D005266:Femoral Neoplasms / Q000188:drug therapy / Q000601:surgery; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D012997:Solvents / Q000627:therapeutic use; D013977:Tibia; D055815:Young Adult
D000438:Alcohols; D012997:Solvents
Adjuvant; Anhydrous alcohol; Chondrosarcoma; Curettage