High-glucose-cultivated peripheral blood mononuclear cells impaired keratinocyte function via reduced IL-22 expression: implications on impaired diabetic wound healing.
Department of Biological Science, National Sun Yat-sen University, Kaohsiung, Taiwan.|Department of Dermatology, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Shu-Mei
SM
Huang
Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ching-Shuang
CS
Wu
Department of Biological Science, National Sun Yat-sen University, Kaohsiung, Taiwan.
David
D
Chao
Department of Dermatology, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.|Center for Lipid and Glycomedicine Research, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chin-Han
CH
Wu
Department of Urology, College of Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ching-Chia
CC
Li
Department of Dermatology, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Gwo-Shing
GS
Chen
Department of Dermatology, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.|Center for Lipid and Glycomedicine Research, Kaohsiung Medical University, Kaohsiung, Taiwan.|Department of Dermatology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Cheng-Che E
CC
Lan
D000328:Adult; D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D017077:Culture Media, Conditioned / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D007378:Interleukins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D019278:Matrix Metalloproteinase 3 / Q000096:biosynthesis / Q000235:genetics; D009994:Osmolar Concentration; D034622:RNA Interference; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D018123:Receptors, Interleukin / Q000502:physiology; D012867:Skin / Q000293:injuries / Q000378:metabolism; D014945:Wound Healing; D000097043:Interleukin-22
D017077:Culture Media, Conditioned; D005947:Glucose; D007378:Interleukins; D019278:Matrix Metalloproteinase 3; D012333:RNA, Messenger; D018123:Receptors, Interleukin; D000097043:Interleukin-22; C433253:IL22RA2 protein, human
MMP-3; high glucose; interleukin-22; keratinocytes; mononuclear cells