An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers.
BACKGROUND
Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers.


METHODS
We genotyped 22,214 (11,421 affected, 10,793 unaffected) mutation carriers belonging to the Consortium of Investigators of Modifiers of BRCA1/2 for 129 mitochondrial polymorphisms using the iCOGS array. Haplogroup inference and association detection were performed using a phylogenetic approach. ALTree was applied to explore the reference mitochondrial evolutionary tree and detect subclades enriched in affected or unaffected individuals.


RESULTS
We discovered that subclade T1a1 was depleted in affected BRCA2 mutation carriers compared with the rest of clade T (hazard ratio (HR) = 0.55; 95% confidence interval (CI), 0.34 to 0.88; P = 0.01). Compared with the most frequent haplogroup in the general population (that is, H and T clades), the T1a1 haplogroup has a HR of 0.62 (95% CI, 0.40 to 0.95; P = 0.03). We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk.


CONCLUSIONS
This study illustrates how original approaches such as the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects.
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. sophie.blein@gmail.com.|Université de Lyon, 69000, Lyon, France. sophie.blein@gmail.com.|Université Lyon 1, 69100, Villeurbanne, France. sophie.blein@gmail.com.
Sophie
S
Blein
Université de Lyon, 69000, Lyon, France. claire.bardel@univ-lyon1.fr.|Université Lyon 1, 69100, Villeurbanne, France. claire.bardel@univ-lyon1.fr.|UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive (LBBE), "Biométrie et Biologie Évolutive", Université Claude Bernard Lyon 1, Bâtiment Grégor Mendel, 43 boulevard du 11 novembre 1918, 69622, Villeurbanne, cedex, France. claire.bardel@univ-lyon1.fr.
Claire
C
Bardel
Université Grenoble Alpes, UMR 5217, Laboratoire d'Informatique de Grenoble (LIG), équipe-projet Multi-programmation et Ordonnancement sur ressources pour les Applications Interactives de Simulation (MOAIS), 38041, Grenoble, France. vincent.danjean@ens-lyon.org.|INRIA Rhône-Alpes, équipe-projet MOAIS, 38334, Saint Ismier, Cedex, France. vincent.danjean@ens-lyon.org.
Vincent
V
Danjean
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. lesley@srl.cam.ac.uk.
Lesley
L
McGuffog
Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia. sue.healey@qimrberghofer.edu.au.
Sue
S
Healey
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. daniel@srl.cam.ac.uk.
Daniel
D
Barrowdale
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. andrewl@srl.cam.ac.uk.
Andrew
A
Lee
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. jgd29@cam.ac.uk.
Joe
J
Dennis
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. karoline@srl.cam.ac.uk.
Karoline B
KB
Kuchenbaecker
Centre de recherche du Centre hospitalier universitaire de Québec, Laval University, Charlesbourg, PQ, Canada. penny.soucy@crchul.ulaval.ca.
Penny
P
Soucy
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA. mt146@cumc.columbia.edu.
Mary Beth
MB
Terry
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY, USA. wkc15@columbia.edu.|Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA. wkc15@columbia.edu.
Wendy K
WK
Chung
Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA. david.goldgar@hsc.utah.edu.
David E
DE
Goldgar
Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA. saundra.buys@hci.utah.edu.
Saundra S
SS
Buys
Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. ramunas.janavicius@santa.lt.|Department of Molecular and Regenerative Medicine, Centre for Innovative Medicine, State Research Institute, Vilnius, Lithuania. ramunas.janavicius@santa.lt.
Ramunas
R
Janavicius
Latvian Biomedical Research and Study Centre, Rātsupītes iela 1, Rīga, LV-1067, Latvia. laima@biomed.lu.lv.
Laima
L
Tihomirova
Division of Hematology Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 9, Boston, MA, 02215-5400, USA. ntung@bidmc.harvard.edu.
Nadine
N
Tung
Department of Genetics, University of Pretoria, Private Bag X20, Hatfield, 0028, Pretoria, South Africa. celmari.dorfling@up.ac.za.
Cecilia M
CM
Dorfling
Department of Genetics, University of Pretoria, Private Bag X20, Hatfield, 0028, Pretoria, South Africa. lizette.vanrensburg@up.ac.za.
Elizabeth J
EJ
van Rensburg
Department of Population Sciences, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. sneuhausen@coh.org.
Susan L
SL
Neuhausen
Department of Population Sciences, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. ycding@coh.org.
Yuan Chun
YC
Ding
Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. anne-marie.gerdes@regionh.dk.
Anne-Marie
AM
Gerdes
Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. bent.ejlertsen@regionh.dk.
Bent
B
Ejlertsen
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. fcn@rh.dk.
Finn C
FC
Nielsen
Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. tvoh@rh.dk.
Thomas Vo
TV
Hansen
Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. aosorio@cnio.es.|Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain. aosorio@cnio.es.
Ana
A
Osorio
Human Genetics Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. jbenitez@cnio.es.|Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain. jbenitez@cnio.es.
Javier
J
Benitez
Medical Oncology Service, Hospital Clínico Universitario Lozano Blesa, Avenida San Juan Bosco, 15, 50009, Zaragoza, Spain. andresraquel@hotmail.com.
Raquel Andrés
RA
Conejero
Holy Cross Hospital, Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale, FL, USA. zdenka.segota@holy-cross.com.|Clinical Cancer Genetics Community Research Network, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. zdenka.segota@holy-cross.com.
Ena
E
Segota
Division of Clinical Cancer Genetics, City of Hope (for the Clinical Cancer Genetics Community Research Network), City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. jweitzel@coh.org.
Jeffrey N
JN
Weitzel
John Muir Medical Center, Walnut Creek, CA, USA; c/o Clinical Cancer Genetics Community Research Network, City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. margo.thelander@johnmuirhealth.com.
Margo
M
Thelander
Istituto FIRC di Oncologia Molecolare (IFOM), Via Adamello 16, 20139, Milan, Italy. paolo.peterlongo@ifom.eu.
Paolo
P
Peterlongo
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. paolo.radice@istitutotumori.mi.it.
Paolo
P
Radice
Division of Clinical Cancer Genetics, City of Hope (for the Clinical Cancer Genetics Community Research Network), City of Hope, 1500 East Duarte Road, Duarte, CA, 91010, USA. valeria.pensotti@ifom.eu.|Cogentech Cancer Genetic Test Laboratory, Via Adamello 16, 20139, Milan, Italy. valeria.pensotti@ifom.eu.
Valeria
V
Pensotti
Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico (CRO), Via Franco Gallini 2, 33081, Aviano, Italy. rdolcetti@cro.it.
Riccardo
R
Dolcetti
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy. bernardo.bonanni@ieo.it.
Bernardo
B
Bonanni
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. bernard.peissel@istitutotumori.mi.it.
Bernard
B
Peissel
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. daniela.zaffaroni@istitutotumori.mi.it.
Daniela
D
Zaffaroni
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. giulietta.scuvera@istitutotumori.m.it.
Giulietta
G
Scuvera
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale dei Tumori (INT), Via Venezian 1, 20133, Milan, Italy. siranoush.manoukian@istitutotumori.mi.it.
Siranoush
S
Manoukian
Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Azienda Ospedaliera Universitaria "San Martino" di Genova, IST Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, 10, 16132, Genoa, Italy. liliana.varesco@hsanmartino.it.
Liliana
L
Varesco
FiorGen Foundation for Pharmacogenomics, Via Luigi Sacconi 6, 50019, Sesto Fiorentino, Italy. gabrycapo86@gmail.com.|Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy. gabrycapo86@gmail.com.
Gabriele L
GL
Capone
Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy. l.papi@dfc.unifi.it.
Laura
L
Papi
Department of Molecular Medicine, Sapienza University, Rome, Italy. laura.ottini@uniroma1.it.
Laura
L
Ottini
Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece. yannouka@rrp.demokritos.gr.
Drakoulis
D
Yannoukakos
Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece. reena@rrp.demokritos.gr.
Irene
I
Konstantopoulou
Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA. judy_garber@dfci.harvard.edu.
Judy
J
Garber
Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. u.hamann@dkfz-heidelberg.de.
Ute
U
Hamann
Clinical Genetics Department, St Michael's Hospital, Southwell Street, Bristol, BS2 8EG, UK. alan.donaldson@uhbristol.nhs.uk.
Alan
A
Donaldson
North West Thames Regional Genetics Service, Kennedy-Galton Centre, Harrow, UK. a.brady@imperial.ac.uk.
Angela
A
Brady
Department of Clinical Genetics, Royal Devon & Exeter Hospital, Barrack Road, Exeter, EX2 5DW, UK. carole.brewer1@nhs.net.
Carole
C
Brewer
Merseyside and Cheshire Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, Merseyside, L8 7SS, UK. claire.foo@lwh.nhs.uk.
Claire
C
Foo
Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK. gareth.evans@cmft.nhs.uk.
D Gareth
DG
Evans
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK. djsf2@medschl.cam.ac.uk.
Debra
D
Frost
Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Trust, Mailpoint 801, South Academic Block, PAH/G/MP105, Tremona Road, Southampton, SO16 6YD, UK. d.m.eccles@soton.ac.uk.
Diana
D
Eccles
Institute of Human Genetics, Northern Genetic Service, International Centre for Life, Newcastle upon Tyne Hospitals NHS Trust, Central Parkway, Newcastle upon Tyne, NE1 4EP, UK. fiona.douglas@nuth.nhs.uk.
Fiona
F
Douglas
Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK. jackie.cook@sch.nhs.uk.
Jackie
J
Cook
Yorkshire Regional Genetics Service, Leeds Teaching Hospitals NHS Trust, Old Medical School, Leeds General Infirmary, Leeds, LS1 3EX, UK. julian.adlard@leedsth.nhs.uk.
Julian
J
Adlard
Leicestershire Clinical Genetics Service, Department of Clinical Genetics, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE1 5WW, UK. julian.barwell@uhl-tr.nhs.uk.
Julian
J
Barwell
Oxford Regional Genetics Service, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, UK. lisa.walker@ouh.nhs.uk.
Lisa
L
Walker
Clinical Genetics Service, Guy's and St Thomas' NHS Foundation Trust, 7th floor, Borough Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT, UK. louise.izatt@gstt.nhs.uk.
Louise
L
Izatt
North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, Barclay House, 37, Queen Square, London, WC1N 3BH, UK. sidel@gosh.nhs.uk.
Lucy E
LE
Side
North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, Barclay House, 37, Queen Square, London, WC1N 3BH, UK. jkennedy@stjames.ie.|Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin, College Green, Dublin 2, Ireland. jkennedy@stjames.ie.|Medical Oncology Service, St James's Hospital, James's Street, Dublin 8, Ireland. jkennedy@stjames.ie.
M John
MJ
Kennedy
Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrooke's Hospital, Level 6, Addenbrooke's Treatment Centre, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, CB2 0QQ, UK. mdt33@cam.ac.uk.
Marc
M
Tischkowitz
All Wales Medical Genetics Services, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK. mark.rogers@wales.nhs.uk.
Mark T
MT
Rogers
South East Scotland Regional Genetic Service, Western General Hospital, David Brock Building, Crewe Road South, Edinburgh, EH4 2XU, UK. mary.porteous@ed.ac.uk.
Mary E
ME
Porteous
Centre for Cancer Research & Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7AE, UK. patrick.morrison@belfasttrust.hscni.net.|Department of Medical Genetics, Belfast Health and Social Care Trust, Belfast City Hospital, Lisburn Road, Belfast, BT9 7AB, UK. patrick.morrison@belfasttrust.hscni.net.
Patrick J
PJ
Morrison
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK. rp356@medschl.cam.ac.uk.
Radka
R
Platte
Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, 123 Old Brompton Road, London, SW7 3RP, UK. rosalind.eeles@icr.ac.uk.
Ros
R
Eeles
Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Block 4, Glasgow, G3 8SJ, UK. rosemarie.davidson@ggc.scot.nhs.uk.
Rosemarie
R
Davidson
South West Thames Regional Genetics Service, Department of Medical Genetics, St George's University of London, Cranmer Terrace, London, SW17 0RE, UK. shodgson@sgul.ac.uk.
Shirley
S
Hodgson
West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Mindelsohn Way, Edgbaston, Birmingham, B15 2TG, UK. trevor.cole@bwhct.nhs.uk.
Trevor
T
Cole
Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA. agodwin@kumc.edu.
Andrew K
AK
Godwin
Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC, 20057, USA. isaacsc@georgetown.edu.
Claudine
C
Isaacs
Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. kathleen.claes@ugent.be.
Kathleen
K
Claes
Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. kim.deleeneer@ugent.be.
Kim
K
De Leeneer
Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany. alfons.meindl@lrz.tu-muenchen.de.
Alfons
A
Meindl
Center of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institut für Humangenetik, Biozentrum, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany. gehrig@biozentrum.uni-wuerzburg.de.
Andrea
A
Gehrig
Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, Center for Integrated Oncology (CIO) Cancer Center Cologne, University Hospital Cologne, Cologne, Germany. barbara.wappenschmidt@uk-koeln.de.|Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931, Cologne, Germany. barbara.wappenschmidt@uk-koeln.de.
Barbara
B
Wappenschmidt
Department of Human Genetics, Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany. c.sutter@med.uni-heidelberg.de.
Christian
C
Sutter
Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany. christoph.engel@imise.uni-leipzig.de.
Christoph
C
Engel
Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany. niederac@med.uni-duesseldorf.de.
Dieter
D
Niederacher
Institute of Cell and Molecular Pathology, Centre for Pathology and Forensic and Genetic Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany. steinemann.doris@mh-hannover.de.
Doris
D
Steinemann
Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105, Kiel, Germany. plendl@medgen.uni-kiel.de.
Hansjoerg
H
Plendl
Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus of Dresden, Technical University Dresden, Dresden, Germany. karin.kast@uniklinikum-dresden.de.
Karin
K
Kast
Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, Center for Integrated Oncology (CIO) Cancer Center Cologne, University Hospital Cologne, Cologne, Germany. kerstin.rhiem@uk-koeln.de.|Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931, Cologne, Germany. kerstin.rhiem@uk-koeln.de.
Kerstin
K
Rhiem
Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany. nina.ditsch@med.uni-muenchen.de.
Nina
N
Ditsch
Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105, Kiel, Germany. norbert.arnold@uksh.de.
Norbert
N
Arnold
Institute of Medical Genetics and Human Genetics, Campus Virchow-Klinikum, Charité Berlin - Universtitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. raymonda.varon-mateeva@charite.de.
Raymonda
R
Varon-Mateeva
Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, Center for Integrated Oncology (CIO) Cancer Center Cologne, University Hospital Cologne, Cologne, Germany. rita.schmutzler@uk-koeln.de.|Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931, Cologne, Germany. rita.schmutzler@uk-koeln.de.|German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC), Cologne, Germany. rita.schmutzler@uk-koeln.de.
Rita K
RK
Schmutzler
Institute of Human Genetics, University Hospital Münster, Vesaliusweg 12-14, 48149, Münster, Germany.
Sabine
S
Preisler-Adams
Institute of Human Genetics, University Hospital Münster, Vesaliusweg 12-14, 48149, Münster, Germany. nadja.bogdanova-markov@ukmuenster.de.
Nadja Bogdanova
NB
Markov
Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany. shan.wang-gohrke@uniklinik.ulm.de.
Shan
S
Wang-Gohrke
Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05, France. antoine.depauw@curie.net.
Antoine
A
de Pauw
Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05, France. cedrick.lefol@curie.net.
Cédrick
C
Lefol
UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive (LBBE), "Biométrie et Biologie Évolutive", Université Claude Bernard Lyon 1, Bâtiment Grégor Mendel, 43 boulevard du 11 novembre 1918, 69622, Villeurbanne, cedex, France. christine.lasset@lyon.unicancer.fr.|Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008, Lyon, France. christine.lasset@lyon.unicancer.fr.
Christine
C
Lasset
Génétique Clinique, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043, Grenoble, cedex 9, France. dleroux@chu-grenoble.fr.|Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706, La Tronche, France. dleroux@chu-grenoble.fr.
Dominique
D
Leroux
Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, 35 rue Dailly, 92210, Saint-Cloud, France. etienne.rouleau@curie.net.
Etienne
E
Rouleau
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. francesca.damiola@lyon.unicancer.fr.
Francesca
F
Damiola
Génétique Clinique, Centre Hospitalier Universitaire de Grenoble, CS 10217, 38043, Grenoble, cedex 9, France. h.dreyfus@isc84.org.|Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706, La Tronche, France. h.dreyfus@isc84.org.
Hélène
H
Dreyfus
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. laure.barjhoux@lyon.unicancer.fr.
Laure
L
Barjhoux
Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05, France. lisa.golmard@curie.net.
Lisa
L
Golmard
Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011, Clermont-Ferrand, France. nancy.uhrammer@cjp.fr.
Nancy
N
Uhrhammer
UMR CNRS 5558, Laboratoire de Biométrie et Biologie Évolutive (LBBE), "Biométrie et Biologie Évolutive", Université Claude Bernard Lyon 1, Bâtiment Grégor Mendel, 43 boulevard du 11 novembre 1918, 69622, Villeurbanne, cedex, France. valerie.bonadona@lyon.unicancer.fr.|Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008, Lyon, France. valerie.bonadona@lyon.unicancer.fr.
Valérie
V
Bonadona
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. valerie.sornin@lyon.unicancer.fr.
Valérie
V
Sornin
Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011, Clermont-Ferrand, France. yves-jean.bignon@cjp.fr.
Yves-Jean
YJ
Bignon
Gynaecological Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital and University of Sydney, Missenden Road, Camperdown, NSW, 2050, Australia. j.carter@sydney.edu.au.
Jonathan
J
Carter
Gynecologic Oncology Group, Department of OB-GYN, University of North Carolina at Chapel Hill, 103B Physicians' Office Building, CB# 7572, Chapel Hill, NC, 27599-7572, USA. linda_van_le@med.unc.edu.
Linda
L
Van Le
Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263-0001, USA. mpiedmon@gogstats.org.
Marion
M
Piedmonte
Women & Infants Hospital, 1 Blackstone Place, Providence, RI, 02905, USA. pdisilvestro@wihri.org.
Paul A
PA
DiSilvestro
Molecular Oncology Laboratory, Health Research Institute of the San Carlos Clinical Hospital (IdISSC), 28040, Madrid, Spain. mdhoya@hotmail.com.
Miguel
M
de la Hoya
Molecular Oncology Laboratory, Health Research Institute of the San Carlos Clinical Hospital (IdISSC), 28040, Madrid, Spain. trinidad.caldes@salud.madrid.org.
Trinidad
T
Caldes
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 700, 00029, Helsinki, Finland. heli.nevanlinna@hus.fi.
Heli
H
Nevanlinna
Department of Clinical Genetics, Helsinki University Central Hospital, Biomedicum Helsinki 1, Haartmaninkatu 8, 00290, Helsinki, Finland. kristiina.aittomaki@hus.fi.
Kristiina
K
Aittomäki
Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, PO Box 2040, 3000, CA, Rotterdam, the Netherlands. a.jager@erasmusmc.nl.
Agnes
A
Jager
Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands. a.vandenouweland@erasmusmc.nl.
Ans Mw
AM
van den Ouweland
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. marleen.kets@radboudumc.nl.
Carolien M
CM
Kets
Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands. c.m.aalfs@amc.uva.nl.
Cora M
CM
Aalfs
Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands. f.v.leeuwen@nki.nl.
Flora E
FE
van Leeuwen
Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands. f.hogervorst@nki.nl.
Frans Bl
FB
Hogervorst
Department of Clinical Genetics, VU University Medical Center Amsterdam, De Boelelaan 1118, 1081 HV, Amsterdam, the Netherlands. h.meijers@vumc.nl.
Hanne Ej
HE
Meijers-Heijboer
Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands. j.c.oosterwijk@umcg.nl.
Jan C
JC
Oosterwijk
Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands. kees.vanroozendaal@mumc.nl.
Kees Ep
KE
van Roozendaal
Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands. m.rookus@nki.nl.
Matti A
MA
Rookus
Department of Human Genetics, Center for Human and Clinical Genetics, Leiden University Medical Center, S4-P PO Box 9600, 2300, RC, Leiden, the Netherlands. p.devilee@lumc.nl.|Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC L1Q, Leiden, the Netherlands. p.devilee@lumc.nl.
Peter
P
Devilee
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands. r.b.vanderluijt@umcutrecht.nl.
Rob B
RB
van der Luijt
Department of Molecular Genetics, National Institute of Oncology, Ráth György u 7-9, PO Box 1525 Budapest PF 21, 1122, Budapest, Hungary. e.olah@oncol.hu.
Edith
E
Olah
Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), University Hospital Vall d'Hebron, Vall d'Hebron Research Institute (VHIR) and Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron 119, 08035, Barcelona, Spain. odiez@vhebron.net.
Orland
O
Diez
Genetic Counseling Unit, Hereditary Cancer Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, 3a planta - Gran Via de l'Hospitalet, 199, 08908, Hospitalet de Llobregat, Barcelona, Spain. ateule@iconcologia.net.
Alex
A
Teulé
Molecular Diagnostic Unit, Hereditary Cancer Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, 3a planta - Gran Via de l'Hospitalet, 199, 08908, Hospitalet de Llobregat, Barcelona, Spain. clazaro@iconcologia.net.
Conxi
C
Lazaro
Genetic Counseling Unit, Hereditary Cancer Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, 3a planta - Gran Via de l'Hospitalet, 199, 08908, Hospitalet de Llobregat, Barcelona, Spain. iblanco@iconcologia.net.
Ignacio
I
Blanco
Molecular Diagnostic Unit, Hereditary Cancer Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)-Catalan Institute of Oncology, Hospital Duran i Reynals, 3a planta - Gran Via de l'Hospitalet, 199, 08908, Hospitalet de Llobregat, Barcelona, Spain. jdelvalle@iconcologia.net.
Jesús
J
Del Valle
Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. aniaj@pum.edu.pl.
Anna
A
Jakubowska
Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. starosta84@wp.pl.
Grzegorz
G
Sukiennicki
Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. jgron@pum.edu.pl.
Jacek
J
Gronwald
Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. lubinski@pum.edu.pl.
Jan
J
Lubinski
Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. k.durda@onet.pl.
Katarzyna
K
Durda
Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111, Szczecin, Poland. ka_jaworska@wp.pl.
Katarzyna
K
Jaworska-Bieniek
Landspítali National University Hospital of Iceland and Faculty of Medicine, School of Health Sciences, University of Iceland School of Medicine, Sæmundargötu 2, 101, Reykjavik, Iceland. bjarniaa@lsh.is.
Bjarni A
BA
Agnarsson
Laboratoire de diagnostic génétique et Service d'Onco-hématologie, Les Hopitaux Universitaire de Strasbourg, Nouvel Hôpital Civil, 1 place de l'Hôpital, BP 426, 67091, Strasbourg, France. christinemaugard@gmail.com.
Christine
C
Maugard
Department of Surgical Sciences, Oncology and Gastroenterology, Padua University, Clinical Surgery II, via Giustiniani 2, 35124, Padua, Italy. albido@unipd.it.|Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128, Padua, Italy. albido@unipd.it.
Alberto
A
Amadori
Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128, Padua, Italy. montagna@unipd.it.
Marco
M
Montagna
Department of Genetics, Portuguese Oncology Institute (IPO-PORTO), Edifício dos Laboratórios, piso 6, 4200-072, Porto, Portugal. manuel.teixeira@ipoporto.min-saude.pt.|Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal. manuel.teixeira@ipoporto.min-saude.pt.
Manuel R
MR
Teixeira
Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia. amanda.spurdle@qimrberghofer.edu.au.
Amanda B
AB
Spurdle
Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, 546 Pine Avenue West, Montreal, QC, J2W 1S6, Canada. william.foulkes@mcgill.ca.
William
W
Foulkes
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. olswold.curtis@mayo.edu.
Curtis
C
Olswold
Department of Health Sciences Research, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA. lindor.noralane@mayo.edu.
Noralane M
NM
Lindor
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. pankratz.vernon@mayo.edu.
Vernon S
VS
Pankratz
National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, MSC 2152, 9000 Rockville Pike, Bethesda, MD, 20892-2152, USA. szaboc@mail.nih.gov.
Csilla I
CI
Szabo
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. lincolna@mskcc.org.
Anne
A
Lincoln
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. jacobsl@mskcc.org.
Lauren
L
Jacobs
Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. corinesm@mskcc.org.
Marina
M
Corines
Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. robsonm@mskcc.org.
Mark
M
Robson
Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. josephv@mskcc.org.
Joseph
J
Vijai
Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090, Vienna, Austria. andreas.berger@meduniwien.ac.at.
Andreas
A
Berger
Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090, Vienna, Austria. anneliese.fink-retter@meduniwien.ac.at.
Anneliese
A
Fink-Retter
Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090, Vienna, Austria. christian.singer@meduniwien.ac.at.
Christian F
CF
Singer
Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090, Vienna, Austria. christine.rappaport@akhwien.at.
Christine
C
Rappaport
Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090, Vienna, Austria. daphne.gschwantler-kaulich@meduniwien.ac.at.
Daphne Geschwantler
DG
Kaulich
Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090, Vienna, Austria. george.pfeiler@meduniwien.ac.at.
Georg
G
Pfeiler
Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090, Vienna, Austria. muy-kheng.tea@meduniwien.ac.at.
Muy-Kheng
MK
Tea
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. greenem@mail.nih.gov.
Mark H
MH
Greene
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. maip@mail.nih.gov.
Phuong L
PL
Mai
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy. rennert@tx.technion.ac.il.|National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Clalit Health Services Carmel Medical Center, 34361, Haifa, Israel. rennert@tx.technion.ac.il.|Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 2 Horev Street, 34362, Haifa, Israel. rennert@tx.technion.ac.il.
Gad
G
Rennert
NN Petrov Institute of Oncology, 68 Leningradskaya Street, Pesochny, 197758, St Petersburg, Russia. evgeny@imyanitov.spb.ru.
Evgeny N
EN
Imyanitov
Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, 6th Floor, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. annamarie.mulligan@uhn.ca.|Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1T8, Canada. annamarie.mulligan@uhn.ca.
Anna Marie
AM
Mulligan
Ontario Cancer Genetics Network, Cancer Care Ontario, 620 University Avenue, Toronto, ON, M5G 2L7, Canada. gord.glendon@cancercare.on.ca.|Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. gord.glendon@cancercare.on.ca.
Gord
G
Glendon
Department of Laboratory Medicine and Pathobiology, University of Toronto, Medical Sciences Building, 6th Floor, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. andrulis@lunenfeld.ca.|Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. andrulis@lunenfeld.ca.|Department of Molecular Genetics, University of Toronto, Medical Science Building, Room 4386, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. andrulis@lunenfeld.ca.
Irene L
IL
Andrulis
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. tchatchou@lunenfeld.ca.
Sandrine
S
Tchatchou
Department of Human Cancer Genetics, 1093 Biomedical Research Tower, 460 West 12th Avenue, Columbus, OH, 43210, USA. amanda.toland@osumc.edu.|Department of Internal Medicine, The Ohio State University Wexner Medical Center, North Doan Tower, 395 West 12th Avenue, Columbus, OH, 43210, USA. amanda.toland@osumc.edu.|Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, 1093 Biomedical Research Tower, 460 West 12th Avenue, Columbus, OH, 43210, USA. amanda.toland@osumc.edu.|The Ohio State University Comprehensive Cancer Center - Arthur G James Cancer Hospital and Richard J Solove Research Institute (OSUCCC - James), 460 West 10th Avenue, Columbus, OH, 43210, USA. amanda.toland@osumc.edu.
Amanda Ewart
AE
Toland
Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Hobrovej 18, 9000, Aalborg, Denmark. isp@rn.dk.
Inge Sokilde
IS
Pedersen
Department of Clinical Genetics, Odense University Hospital, Soenderboulevard 29, 5000, Odense C, Denmark. mads.thomassen@ouh.rsyd.dk.
Mads
M
Thomassen
Department of Clinical Genetics, Odense University Hospital, Soenderboulevard 29, 5000, Odense C, Denmark. torben.kruse@ouh.rsyd.dk.
Torben A
TA
Kruse
Department of Clinical Genetics, Aarhus University Hospital, Brendstrupgårdsvej 21 C, 8200, Aarhus N, Denmark. uffejens@rm.dk.
Uffe Birk
UB
Jensen
Laboratorio di Genetica Oncologica, Divisione di Anatomia Patologica e di Diagnostica Molecolare ed Ultrastrutturale, Azienda Ospedaliero Universitaria Pisana - Ospedale S Chiara, via Roma 67, 56126, Pisa, Italy. adelaide.caligo@do.unipi.it.
Maria A
MA
Caligo
Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Tel Aviv, Israel. eitan.friedman@sheba.health.gov.il.
Eitan
E
Friedman
Institute of Oncology, Rivka Ziv Medical Center, Maimonides, 13100, Safed, Israel. jamal.zidan@ziv.health.gov.il.
Jamal
J
Zidan
Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621, Tel Aviv, Israel. yael.laitman@sheba.health.gov.il.
Yael
Y
Laitman
Department of Cancer Genetics, Karolinska University Hospital, Solna L8:02, SE-171 76, Stockholm, Sweden. annika.lindblom@karolinska.se.
Annika
A
Lindblom
Oncology, Department of Radiation Sciences, Umeå University, SE-901 87, Umeå, Sweden. beatrice.melin@onkologi.umu.se.
Beatrice
B
Melin
Department of Oncology-Pathology, Karolinska University Hospital, K7, Ärftlighetsmottagningen, Radiumhemmet, 171 76, Stockholm, Sweden. brita.wasteson-arver@karolinska.se.
Brita
B
Arver
Division of Oncology and Pathology, Department of Clinical Sciences, Lund University Hospital, Barngatan 2B, SE-221 85, Lund, Sweden. niklas.loman@med.lu.se.
Niklas
N
Loman
Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85, Uppsala, Sweden. richard.rosenquist@igp.uu.se.
Richard
R
Rosenquist
Center for Clinical Cancer Genetics and Global Health, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL, 60637, USA. folopade@medicine.bsd.uchicago.edu.
Olufunmilayo I
OI
Olopade
Department of Medicine and Genetics, University of California, San Francisco, CA, USA. nussbaumr@humgen.ucsf.edu.
Robert L
RL
Nussbaum
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Norris Comprehensive Cancer Center, NOR-4435, Los Angeles, CA, 90089-9175, USA. sramus@usc.edu.
Susan J
SJ
Ramus
Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA, 19104-3309, USA. knathans@exchange.upenn.edu.
Katherine L
KL
Nathanson
Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA, 19104-3309, USA. susan.domchek@uphs.upenn.edu.
Susan M
SM
Domchek
Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA, 19104-3309, USA. rebbeck@exchange.upenn.edu.
Timothy R
TR
Rebbeck
Division of Cancer Medicine, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1354, PO Box 301439, Houston, TX, 77230-1439, USA. barun@mdanderson.org.
Banu K
BK
Arun
Sir Peter MacCallum Department of Oncology, Familial Cancer Centre, Peter MacCallum Cancer Centre, level 3, 10 St Andrews Place, East Melbourne, VIC, 3002, Australia. gillian.mitchell@petermac.org.|Sir Peter MacCallum Department of Oncology, The University of Melbourne, Level 5, 161 Barry Street, Parkville, 3010, VIC, Australia. gillian.mitchell@petermac.org.
Gillian
G
Mitchell
Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA. beth.karlan@cshs.org.
Beth Y
BY
Karlan
Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA. jenny.lester@cshs.org.
Jenny
J
Lester
Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA, 90048, USA. sandra.orsulic@cshs.org.
Sandra
S
Orsulic
Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05, France. dominique.stoppa-lyonnet@curie.net.|Service de génétique oncologique, Institut Curie, Inserm U830, 26 rue d'Ulm, 75248, Paris, France. dominique.stoppa-lyonnet@curie.net.|Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, 15 rue de l'école de médecine, 75006, Paris, France. dominique.stoppa-lyonnet@curie.net.
Dominique
D
Stoppa-Lyonnet
Génétique médicale, Faculté de Médecine Lyon Est, Université Claude Bernard Lyon 1, 8 avenue Rockefeller, 69373, Lyon, Cedex 08, France.|Institut National du Cancer (INCa), La Fondation Synergie Lyon Cancer, Centre Léon Bérard, 28 rue Laënnec, 69008, Lyon, Cedex 08, France.
Gilles
G
Thomas
Centre de recherche du Centre hospitalier universitaire de Québec, Laval University, Charlesbourg, PQ, Canada. jacques.simard@crchul.ulaval.ca.
Jacques
J
Simard
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. couch.fergus@mayo.edu.|Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. couch.fergus@mayo.edu.
Fergus J
FJ
Couch
Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA. offitk@mskcc.org.
Kenneth
K
Offit
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. douglas@srl.cam.ac.uk.
Douglas F
DF
Easton
Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia. georgia.trench@qimrberghofer.edu.au.
Georgia
G
Chenevix-Trench
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. antonis@srl.cam.ac.uk.
Antonis C
AC
Antoniou
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. sylvie.mazoyer@lyon.unicancer.fr.|Université de Lyon, 69000, Lyon, France. sylvie.mazoyer@lyon.unicancer.fr.|Université Lyon 1, 69100, Villeurbanne, France. sylvie.mazoyer@lyon.unicancer.fr.
Sylvie
S
Mazoyer
Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, USA. catherine.phelan@moffitt.org.
Catherine M
CM
Phelan
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.|Université de Lyon, 69000, Lyon, France.|Université Lyon 1, 69100, Villeurbanne, France.|Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, 69373, Lyon, Cedex 08, France.
Olga M
OM
Sinilnikova
INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France. david.cox@lyon.unicancer.fr.|Université de Lyon, 69000, Lyon, France. david.cox@lyon.unicancer.fr.|Université Lyon 1, 69100, Villeurbanne, France. david.cox@lyon.unicancer.fr.
David G
DG
Cox
D019313:BRCA1 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D024522:Genes, BRCA2; D050259:Genes, Mitochondrial; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006579:Heterozygote; D006801:Humans; D009154:Mutation; D010802:Phylogeny; D012306:Risk
D019313:BRCA1 Protein