Mesenchymal stem cells in the treatment of inflammatory and autoimmune diseases in experimental animal models.
Multipotent mesenchymal stromal cells [also known as mesenchymal stem cells (MSCs)] are currently being studied as a cell-based treatment for inflammatory disorders. Experimental animal models of human immune-mediated diseases have been instrumental in establishing their immunosuppressive properties. In this review, we summarize recent studies examining the effectiveness of MSCs as immunotherapy in several widely-studied animal models, including type 1 diabetes, experimental autoimmune arthritis, experimental autoimmune encephalomyelitis, inflammatory bowel disease, graft-vs-host disease, and systemic lupus erythematosus. In addition, we discuss mechanisms identified by which MSCs mediate immune suppression in specific disease models, and potential sources of functional variability of MSCs between studies.
Matthew W Klinker, Cheng-Hong Wei, Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD 20993-0002, United States.
Matthew W
MW
Klinker
Matthew W Klinker, Cheng-Hong Wei, Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD 20993-0002, United States.
Cheng-Hong
CH
Wei
Animal models; Autoimmunity; Immunotherapy; Inflammation; Mesenchymal stem cells; Mesenchymal stromal cells