Helicobacter pylori vs coronary heart disease - searching for connections.
In this review, we discussed the findings and concepts underlying the potential role of Helicobacter pylori (H. pylori) infections in the initiation, development or persistence of atherosclerosis and coronary heart disease (CHD). This Gram-negative bacterium was described by Marshall and Warren in 1984. The majority of infected subjects carries and transmits H. pylori with no symptoms; however, in some individuals these bacteria may cause peptic ulcers, and even gastric cancers. The widespread prevalence of H. pylori infections and the fact that frequently they remain asymptomatic may suggest that, similarly to intestinal microflora, H. pylori may deliver antigens that stimulate not only local, but also systemic inflammatory response. Recently, possible association between H. pylori infection and extragastric disorders has been suggested. Knowledge on the etiology of atherosclerosis together with current findings in the area of H. pylori infections constitute the background for the newly proposed hypothesis that those two processes may be related. Many research studies confirm the indirect association between the prevalence of H. pylori and the occurrence of CHD. According to majority of findings the involvement of H. pylori in this process is based on the chronic inflammation which might facilitate the CHD-related pathologies. It needs to be elucidated, if the infection initiate or just accelerate the formation of atheromatous plaque.
Magdalena Chmiela, Adrian Gajewski, Karolina Rudnicka, Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, 90-236 Łódź, Poland.
Magdalena
M
Chmiela
Magdalena Chmiela, Adrian Gajewski, Karolina Rudnicka, Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, 90-236 Łódź, Poland.
Adrian
A
Gajewski
Magdalena Chmiela, Adrian Gajewski, Karolina Rudnicka, Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Łódź, 90-236 Łódź, Poland.
Karolina
K
Rudnicka
Coronary heart disease; Helicobacter pylori; Inflammation; Lipopolysaccharide; Microbiota