Targeting tumor-associated macrophages in cancer therapy and understanding their complexity.
Macrophage infiltration has been identified as an independent, poor prognostic factor for patients afflicted with various cancer entities. However, the characterization of tumor-associated macrophages (TAMs) prior to and following cancer patient treatment has been limited. Our study analyzed tumor biopsies before and after anti-CSF-1R antibody treatment unraveling the nature of TAMs and providing novel insights into their phenotypic and functional characteristics in cancer.
Roche Pharmaceutical Research and Early Development; Discovery Oncology ; Roche Innovation Center Penzberg ; Penzberg, Germany.
Michael A
MA
Cannarile
Roche Pharmaceutical Research and Early Development; Discovery Oncology ; Roche Innovation Center Penzberg ; Penzberg, Germany.
Carola H
CH
Ries
Roche Pharmaceutical Research and Early Development; Discovery Oncology ; Roche Innovation Center Penzberg ; Penzberg, Germany.
Sabine
S
Hoves
Roche Pharmaceutical Research and Early Development; Discovery Oncology ; Roche Innovation Center Penzberg ; Penzberg, Germany.
Dominik
D
Rüttinger
CSF-1R; RG7155; TAM depletion; myeloid cells; tumor-associated macrophages