No longer falling on deaf ears: mechanisms of degeneration and regeneration of cochlear ribbon synapses.
Cochlear ribbon synapses are required for the rapid and precise neural transmission of acoustic signals from inner hair cells to the spiral ganglion neurons. Emerging evidence suggests that damage to these synapses represents an important form of cochlear neuropathy that might be highly prevalent in sensorineural hearing loss. In this review, we discuss our current knowledge on how ribbon synapses are damaged by noise and during aging, as well as potential strategies to promote ribbon synapse regeneration for hearing restoration.
Kresge Hearing Research Institute, Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Guoqiang
G
Wan
Kresge Hearing Research Institute, Department of Otolaryngology - Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: corfas@med.umich.edu.
Gabriel
G
Corfas
D000818:Animals; D003051:Cochlea / Q000294:innervation* / Q000502:physiology*; D003638:Deafness / Q000503:physiopathology*; D018698:Glutamic Acid / Q000502:physiology; D006198:Hair Cells, Auditory / Q000502:physiology; D006309:Hearing / Q000502:physiology; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology; D006801:Humans; D009410:Nerve Degeneration / Q000503:physiopathology; D009416:Nerve Regeneration / Q000502:physiology; D011304:Presbycusis / Q000503:physiopathology; D013136:Spiral Ganglion / Q000502:physiology; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
D018698:Glutamic Acid