Predicting the emergence of anemia--A large cohort study.
OBJECTIVE
We aimed to find predictors for development of anemia in a large cohort of adults.


METHODS
Cohort study of a large health database from a screening center at the Rabin Medical Center in Israel, between the years 2000-2013. We asked which variables, known at the first visit, would predict anemia at the last visit. Multivariable analysis was conducted using stepwise logistic regression analysis. Odds ratios (ORs) for anemia with 95% confidence intervals (CIs) were calculated.


RESULTS
Our cohort included 10,577 people. At baseline 4.4% were diagnosed with anemia and excluded. Therefore, 10,093 subjects, with a mean age of 42.3 ± 9 years comprised our study sample. At the end of follow-up of 4.7 ± 3.1 years, 307 developed anemia (3%). In men, independent predictors for development of anemia were diabetes mellitus (OR 3.00, 95% CI 1.41-6.39), age (OR 1.03, 95% CI 1.03-1.05, for 1 year increment), low MCV (OR 0.92, 95% CI 0.89-0.96, for every 1 fL unit increment) and elevated platelet count (OR 1.004, 95% CI 1.00-1.01 for 1000/μL unit increment). For women, high total serum protein level was a strong predictor for anemia (OR 3.44, 95% CI 2.33-5.08 for 1mg/dL increment) as well as low triglycerides (OR 0.996, 95% CI 0.993-1.000 for 1mg/dL increment).


CONCLUSIONS
Subgroups who are prone to develop anemia include men with diabetes, and women with an elevated serum protein level and low triglycerides.
Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Tel-Aviv University, Israel; Institute of Hematology, Rabin Medical Center, Beilinson Hospital, Tel-Aviv University, Israel; Sacker Faculty of Medicine, Tel-Aviv University, Israel. Electronic address: anatga2@clalit.org.il.
Anat
A
Gafter-Gvili
Department of Medicine F-Recanati, Rabin Medical Center, Beilinson Hospital, Tel-Aviv University, Israel; Sacker Faculty of Medicine, Tel-Aviv University, Israel.
Eytan
E
Cohen
Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Tel-Aviv University, Israel; Sacker Faculty of Medicine, Tel-Aviv University, Israel.
Tomer
T
Avni
Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Tel-Aviv University, Israel; Sacker Faculty of Medicine, Tel-Aviv University, Israel.
Alon
A
Grossman
Institute of Hematology, Rabin Medical Center, Beilinson Hospital, Tel-Aviv University, Israel; Sacker Faculty of Medicine, Tel-Aviv University, Israel.
Liat
L
Vidal
Department of Medicine F-Recanati, Rabin Medical Center, Beilinson Hospital, Tel-Aviv University, Israel; Sacker Faculty of Medicine, Tel-Aviv University, Israel.
Moshe
M
Garty
Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Tel-Aviv University, Israel; Sacker Faculty of Medicine, Tel-Aviv University, Israel.
Leonard
L
Leibovici
Institute of Hematology, Rabin Medical Center, Beilinson Hospital, Tel-Aviv University, Israel; Sacker Faculty of Medicine, Tel-Aviv University, Israel.
Ilan
I
Krause
D000328:Adult; D000740:Anemia / Q000175:diagnosis* / Q000453:epidemiology* / Q000378:metabolism; D015331:Cohort Studies; D005260:Female; D006304:Health Status; D006801:Humans; D007557:Israel; D016015:Logistic Models; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors
Anemia; Diabetes; Predictors; Triglycerides