CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer.
In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regulates the genomic localization of BAF155 (a SWI/SNF subunit involved in chromatin remodeling) through post-translational methylation at R1064 arginine residues. This modification leads to the relocalization of BAF155-containing SWI/SNF complexes to regions containing genes involved in the Myc oncogenic pathway. The results presented are evidence that these interactions constitute a mechanism by which the BAF155 chromatin remodeling factor contributes to cancer.
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Av. Gran Via de L'Hospitalet 199-203, L'Hospitalet del Llobregat, Barcelona, Catalonia, 08908, Spain. ostefansson@idibell.cat.|Cancer Research Laboratory, Faculty of Medicine, University of Iceland, Sæmundargötu 2, 101, Reykjavík, Iceland. ostefansson@idibell.cat.
Olafur A
OA
Stefansson
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Av. Gran Via de L'Hospitalet 199-203, L'Hospitalet del Llobregat, Barcelona, Catalonia, 08908, Spain. mesteller@idibell.cat.|Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, 08908, Spain. mesteller@idibell.cat.|Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, 08010, Spain. mesteller@idibell.cat.
Manel
M
Esteller
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D011484:Protein-Arginine N-Methyltransferases / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors; D011484:Protein-Arginine N-Methyltransferases