Vitamin D and the risk of atrial fibrillation--the Rotterdam Study.
Atrial fibrillation (AF) is the most common chronic arrhythmia and it increases the risk of cardiovascular morbidity and mortality. Still there is not a complete understanding of its etiology and underlying pathways. Vitamin D might regulate renin-angiotensin-aldosterone system and might be involved in inflammation, both implicated in the pathophysiology of AF. The objective of this work was to investigate the association between vitamin D status with the risk of AF in the elderly. This study was conducted within the Rotterdam Study, a community-based cohort of middle-aged and elderly participants in Rotterdam, The Netherlands. We had 3,395 participants who were free of AF diagnosis at the start of our study and who had vitamin D data available. We analyzed the association between serum 25-hydroxivitamin D (25(OH)D) and incidence of AF using Cox regression models. Vitamin D deficiency was defined as serum 25(OH)D concentrations <50 nmol/l, insufficiency between 50 nmol/l and 75 nmol/l, while serum 25(OH)D concentrations equal to and above 75 nmol/l were considered as adequate. After mean follow-up of 12.0 years 263 (7.7%) participants were diagnosed with incident AF. Vitamin D status was not associated with AF in any of the 3 multivariate models tested (model adjusted for socio-demographic factors and life-style factors: HR per 10 unit increment in serum 25(OH)D 0.96, 95% CI: 0.91-1.02; HR for insufficiency: 0.82, 95%CI: 0.60-1.11,and HR for adequate status: 0.76, 95%CI: 0.52-1.12 compared to deficiency). This prospective cohort study does not support the hypothesis that vitamin D status is associated with AF.
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Anna
A
Vitezova
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Natasha S
NS
Cartolano
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Jan
J
Heeringa
Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
M Carola
MC
Zillikens
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Albert
A
Hofman
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Oscar H
OH
Franco
Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Jessica C
JC
Kiefte-de Jong
D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood*
D014807:Vitamin D; C104450:25-hydroxyvitamin D