Association of ACE polymorphism and diabetic nephropathy susceptibility.
OBJECTIVE
The study was aimed to analyze whether ACE rs267604983 polymorphism was related to the onset of diabetic nephropathy (DN).


METHODS
80 DN patients and 78 healthy controls were enrolled in the study. The differences of age, sex, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP) between two groups were analyzed. The genotyping of ACE rs267604983 was conducted by the technology of PCR-HRM. Odds ratio (ORs) with 95% CI were used to evaluate the relationship of ACE rs267604983 with DN susceptibility.


RESULTS
The AA genotype of ACE rs267604983 was remarkably associated with the risk for DN (OR = 2.90, 95% CI = 1.12-7.51). In addition, for the A allele carriers, the risk for DN increased 1.87 fold (OR = 1.87, 95% CI = 1.16-3.01). The subgroup analysis showed that the AA genotype was found higher in normal albuminuria group than other groups (P = 0.006), while AG genotype was higher in macro albuminuria group (P = 0.036).


CONCLUSIONS
ACE rs267604983 polymorphism is associated with the risk of DN. AA genotype and A allele may increase the risk for DN. Furthermore, AA and AG genotypes may have effects on the subgroups of DN.
Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University Shandong, Jinan 250021, China.
Hongbo
H
Ma
Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University Shandong, Jinan 250021, China.
Che
C
Yu
Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong University Shandong, Jinan 250021, China.
Rong
R
Wang
ACE; diabetic nephropathy; polymorphism; susceptibility