The neutrophil-to-lymphocyte ratio is an independent prognostic factor in patients with peripheral T-cell lymphoma, unspecified.
Peripheral T-cell lymphoma (PTCL) encompasses a group of rare and aggressive lymphomas. PTCL, unspecified (PTCLU) is the most common subtype of PTCL, and carries a poor prognosis. The International Prognostic Index (IPI) and the Prognostic Index for PTCLU (PIT) scoring systems are powerful risk-stratification tools in patients with PTCL. The aim of this study was to evaluate whether the neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor in PTCLU. We retrospectively studied 83 patients with diagnosis of PTCLU. In the univariate analysis, NLR ≥ 4 was associated with worse overall survival (HR 3.96, 95% CI 1.92-8.17; p < 0.001). In the multivariate analysis, NLR ≥ 4 was independently associated with worse overall survival after adjustment for the PIT score (HR 4.30, 95% CI 1.90-9.69; p < 0.001), and for the IPI score (HR 2.60, 95% CI 1. 12-6.04; p = 0.03). Our study suggests the NLR could be helpful in refining the survival prognostication in patients with PTCLU.
a Department of Oncology and Radiotherapy , Lima , Peru.
Brady E
BE
Beltran
a Department of Oncology and Radiotherapy , Lima , Peru.
Christian
C
Aguilar
b Department of Pathology , Hospital Nacional Edgardo Rebagliati Martins , Lima , Peru.
Pilar
P
Quiñones
b Department of Pathology , Hospital Nacional Edgardo Rebagliati Martins , Lima , Peru.
Domingo
D
Morales
c Division of Malignant Hematology, Moffitt Cancer and Research Institute, University of South Florida , Tampa , FL , USA.
Julio C
JC
Chavez
c Division of Malignant Hematology, Moffitt Cancer and Research Institute, University of South Florida , Tampa , FL , USA.
Eduardo M
EM
Sotomayor
d Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School Boston , MA , USA.
Jorge J
JJ
Castillo
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes; D016411:Lymphoma, T-Cell, Peripheral / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009504:Neutrophils; D016017:Odds Ratio; D011379:Prognosis; D016896:Treatment Outcome; D055815:Young Adult
D015415:Biomarkers
PTCL; lymphopenia; neutrophil; neutrophil-to-lymphocyte ratio; peripheral T-cell lymphoma; prognostic factor; unspecified