Fluid dynamics simulation of right ventricular outflow tract oversizing.
OBJECTIVE
Repair of the right ventricular outflow tract (RVOT) in paediatric cardiac surgery remains challenging due to the high reoperation rate. Intimal hyperplasia and consequent arteriosclerosis is one of the most important limitation factors for graft durability. Since local shear stress and pressure are predictive elements for intimal hyperplasia and wall degeneration, we sought to determine in an oversized 12-mm RVOT model, with computed fluid dynamics simulation, the local haemodynamical factors that may explain intimal hyperplasia. This was done with the aim of identifying the optimal degree of oversizing for a 12-mm native RVOT.


METHODS
Twenty domestic pigs, with a weight of 24.6 ± 0.89 kg and a native RVOT diameter of 12 ± 1.7 mm, had valve conduits of 12, 16, 18 and 20 mm implanted. Pressure and flow were measured at 75, 100 and 125% of normal flow at RVOT at the pulmonary artery, pulmonary artery bifurcation and at the left and right pulmonary arteries. Three-dimensional computed fluid dynamics (CFD) simulation in all four geometries in all flow modalities was performed. Local shear stress and pressure conditions were investigated.


RESULTS
Corresponding to 75, 100 and 125% of steady-state flow, three inlet velocity profiles were obtained, 0.2, 0.29 and 0.36 m/s, respectively. At inflow velocity profiles, low shear stress areas, ranged from 0 to 2 Pa, combined with high-pressure areas ranging from 11.5 to 12.1 mmHg that were found at distal anastomosis, at bifurcation and at the ostia of the left and right pulmonary arteries in all geometries.


CONCLUSIONS
In all three oversized geometries, the local reparation of shear stress and pressure in the 16-mm model showed a similar local profile as in the native 12 mm RVOT. According to these findings, we suggest oversizing the natural 12-mm RVOT by not more than 4 mm. The elements responsible for wall degeneration and intimal hyperplasia remain very similar to the conditions present in native RVOT.
Department of Surgery and Anesthesiology, Cardiovascular Research, University Hospital Lausanne, Lausanne, Switzerland denis.berdajs@bluewin.ch.
Denis
D
Berdajs
Department of Surgery and Anesthesiology, Cardiovascular Research, University Hospital Lausanne, Lausanne, Switzerland.
Selim
S
Mosbahi
CFS Engineering, Lausanne, Switzerland.
Jan
J
Vos
CFS Engineering, Lausanne, Switzerland.
Dominique
D
Charbonnier
Department of Cardiology, University Hospital Lausanne, Lausanne, Switzerland.
Roger
R
Hullin
Department of Surgery and Anesthesiology, Cardiovascular Research, University Hospital Lausanne, Lausanne, Switzerland.
Ludwig K
LK
von Segesser
D000818:Animals; D019917:Blood Vessel Prosthesis Implantation; D004195:Disease Models, Animal; D006439:Hemodynamics; D006965:Hyperplasia / Q000503:physiopathology; D011651:Pulmonary Artery / Q000601:surgery; D033081:Shear Strength; D013314:Stress, Mechanical; D034421:Sus scrofa; D017539:Tunica Intima / Q000473:pathology; D014694:Ventricular Outflow Obstruction / Q000503:physiopathology* / Q000601:surgery
Computational fluid dynamics modelling; Pulmonary artery; Right ventricular outflow tract