Advances in the understanding of the clinically relevant genetic pathways and molecular aspects of canine mammary tumours. Part 2: invasion, angiogenesis, metastasis and therapy.
Significant advances have been made recently in the understanding of the molecular events and critical pathways associated with and driving cancer of the mammary gland in humans and dogs. The study of canine mammary tumour biology, particularly the interactions of neoplastic cells with stromal and immune cells, is crucial for the development of novel effective therapeutic agents and strategies. This second part of a two-part review discusses some of the latest advances in the understanding of the clinically relevant genetic and molecular pathways involved in metastasis and in the interactions between tumour and stromal cells, including inflammatory and immune cells, cancer-associated fibroblasts, and endothelial cells. Recent experimental data on the role of matrix-degrading proteases and angiogenic factors are also discussed. Finally, the clinical utility of different non-surgical therapeutic modalities is reviewed.
Faculty of Veterinary Medicine of University Lusófona of Humanities and Technologies, Lisbon, Portugal; Research Centre for Biosciences and Health Technologies (CBIOS), Lisbon, Portugal.
A A
AA
Santos
Department of Veterinary Clinics of the Biomedical Sciences Institute of Abel Salazar (ICBAS), University of Porto, Portugal; Animal Science and Study Centre/Food and Agrarian Sciences and Technologies Institute (CECA/ICETA), University of Porto, Portugal. Electronic address: ajmatos@icbas.up.pt.
A J F
AJ
Matos
D000818:Animals; D004283:Dog Diseases / Q000473:pathology* / Q000628:therapy; D004285:Dogs; D005260:Female; D015674:Mammary Neoplasms, Animal / Q000235:genetics* / Q000628:therapy; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000662:veterinary*
Dog; Genetic pathways; Mammary tumour; Metastasis; Molecular pathways; Therapy; Tumour stroma