Genital soft tissue tumors.
Mesenchymal neoplasms of the vulvovaginal and inguinoscrotal regions are among the most diagnostically challenging specimens in the pathology laboratory owing largely to their unique intersection between general soft tissue tumors and relatively genital-specific mesenchymal tumors. Genital stromal tumors are a unique subset of soft tissue tumors encountered at this location, and this group includes fibroepithelial stromal polyp, superficial (cervicovaginal) myofibroblastoma, cellular angiofibroma, mammary-type myofibroblastoma, angiomyofibroblastoma and aggressive angiomyxoma. Aside from the striking morphologic and immunophenotypic similarity that is seen with these entities, there is evidence that a subset of genital stromal tumors may be linked genetically. This review will focus on simplifying this group of tumors and provide the pathologist or dermatopathologist with practical management information. Smooth muscle tumors of the external genitalia will also be discussed.
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.|Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
John K
JK
Schoolmeester
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Karen J
KJ
Fritchie
D003937:Diagnosis, Differential; D005260:Female; D005833:Genital Neoplasms, Female / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D005834:Genital Neoplasms, Male / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D012983:Soft Tissue Neoplasms / Q000145:classification / Q000175:diagnosis / Q000473:pathology*
angiomyofibroblastoma; angiomyxoma; cellular angiofibroma; genital stromal tumors; smooth muscle tumors