[Functions of inflammatory factor in non-tumor deep venous thrombosis of lower extremity].
OBJECTIVE
To explore the functions of inflammatory cytokine, tissue factor (TF) and cancer procoagulant (CP) in non-tumor deep venous thrombosis (NT-DVT).


METHODS
A total of 17 NT-DVT patients (5 males and 12 females) were selected for NT-DVT group while 20 voluntary (10 males and 10 females) blood donors for control group from May 2012 to March 2013. The levels of inflammatory cytokines interleukin 1β (IL-1 β), IL-18, tumor necrosis factor alpha (TNF-α), TF and CP were tested by enzyme-linked immunosorbent assay (ELISA) before and after treatment. Also the correlations of inflammatory cytokines and TF were determined.


RESULTS
The levels of inflammatory cytokines and TF were higher in NT-DVT than those in control group pre-treatment ((153.13 ± 2.30) vs (59.26 ± 1.57) ng/L, (364.27 ± 1.46) vs (67.46 ± 1.48) ng/L, (363.51 ± 1.85) vs (216.42 ± 1.55) µg/L, (66.90 ± 1.44) vs (14.55 ± 1.52) ng/L, all P < 0.05). And after anticoagulant therapy, the levels decreased (all P < 0.05). Also the levels of IL-1β,IL-18 and TNF-α were positively correlated with TF pre-treatment. And the correlation coefficients were 0.492 (P = 0.045), 0.652 (P = 0.005) and 0.511(P = 0.036) respectively. Compared with control group, the plasma level of CP had no obvious change before and after treatment (both P > 0.05).


CONCLUSIONS
A high level of inflammatory cytokines is an important risk factor for NT-DVT.
Department of Clinical Medicine, Jiangsu Subei People's Hospital, Yangzhou Institute of Hematology Laboratory, Yangzhou 225001, China.
Xing
X
Sun
Department of Clinical Medicine, Jiangsu Subei People's Hospital, Yangzhou Institute of Hematology Laboratory, Yangzhou 225001, China.
Lianjun
L
Shen
Department of Clinical Medicine, Jiangsu Subei People's Hospital, Yangzhou Institute of Hematology Laboratory, Yangzhou 225001, China.
Wei
W
Gu
Department of Clinical Medicine, Jiangsu Subei People's Hospital, Yangzhou Institute of Hematology Laboratory, Yangzhou 225001, China.
Dan
D
Shan
Department of Clinical Medicine, Jiangsu Subei People's Hospital, Yangzhou Institute of Hematology Laboratory, Yangzhou 225001, China.
Minmin
M
Ren
Department of Clinical Medicine, Jiangsu Subei People's Hospital, Yangzhou Institute of Hematology Laboratory, Yangzhou 225001, China.
Hua
H
Qiu
Department of Clinical Medicine, Jiangsu Subei People's Hospital, Yangzhou Institute of Hematology Laboratory, Yangzhou 225001, China. Email: maolujiu918@163.com.
Jian
J
Gu
D016207:Cytokines; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation; D007866:Leg; D035002:Lower Extremity; D008297:Male; D009369:Neoplasms; D013925:Thromboplastin; D020246:Venous Thrombosis
D016207:Cytokines; D013925:Thromboplastin