Kikuchi's Disease: A Rare Cause of Fever of Unknown Origin.
Kikuchi Fujimoto Disease (KFD) or histiocytic necrotizing lymphadenitis can present with unexplained fever and lymphadenopathy. It is often mistaken for more serious conditions like malignant lymphoma or tuberculosis. First case was described by Kikuchi in Japan, very few cases have been reported in Pakistan. A middle aged female presented with fever and body aches for one month. She was investigated extensively for pyrexia of unknown origin, all of which came out to be normal except a raised ESR. Anti-tuberculous drugs were started on clinical suspicion, with no improvement after a month. Later, a detailed physical examination revealed cervical lymphadenopathy. One of the lymph nodes was excised and biopsied. The histopathology suggested Kikuchi's disease. Oral Prednisolone was started showing improvement. Her fever subsided and lymph nodes disappeared at the follow-up visit. No relapse was encountered in the subsequent visits.
Department of Medicine, Women Medical College, BBS Teaching Hospital, Abbottabad.
Mir
M
Jalal-ud-din
Department of Medicine, Women Medical College, BBS Teaching Hospital, Abbottabad.
Muhammad Munir
MM
Noor
Department of Medicine, Women Medical College, BBS Teaching Hospital, Abbottabad.
Shadab
S
Ali
Department of Medicine, Women Medical College, BBS Teaching Hospital, Abbottabad.
Rashid
R
Ali
D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005335:Fever of Unknown Origin / Q000188:drug therapy / Q000209:etiology*; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D009333:Neck; D010808:Physical Examination; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome; D014388:Tuberculosis, Lymph Node
D011239:Prednisolone