Oxygen in human health from life to death--An approach to teaching redox biology and signaling to graduate and medical students.
In the absence of oxygen human life is measured in minutes. In the presence of oxygen, normal metabolism generates reactive species (ROS) that have the potential to cause cell injury contributing to human aging and disease. Between these extremes, organisms have developed means for sensing oxygen and ROS and regulating their cellular processes in response. Redox signaling contributes to the control of cell proliferation and death. Aberrant redox signaling underlies many human diseases. The attributes acquired by altered redox homeostasis in cancer cells illustrate this particularly well. This teaching review and the accompanying illustrations provide an introduction to redox biology and signaling aimed at instructors of graduate and medical students.
Department of Pathology, University of Arizona, PO Box 24-5043, Tucson, AZ 85724-5043, USA. Electronic address: mmbriehl@pathology.arizona.edu.
Margaret M
MM
Briehl
D000375:Aging / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D013337:Students, Medical
D017382:Reactive Oxygen Species; D010100:Oxygen
Apoptosis; Cancer; Hydrogen peroxide; Mitochondria; Proliferation; Superoxide