Dysregulation of male sex hormones in chronic hepatitis C patients.
Chronic hepatitis C (HCV) infection is a serious problem all over the world and has a special importance in Egypt, where the prevalence of infection is 14.7% of population. In males, HCV is associated with sexual dysfunction and changes in the semen parameters. This study aimed at estimation of a panel of the most important related hormones in the serum of patients and illustration of their correlation to the routine laboratory investigations. The four studied hormones showed alteration in the patients in comparison with the controls. While androstenedione, prolactin and testosterone were significantly increased in patients, dehydroepiandrosterone sulphate was decreased. These changes in the hormones were not related to the liver functions, pathological grade or even viral load. We hypothesised a model of how HCV can induce these hormonal changes and recommended to add these hormones to the follow-up panel of male patients with HCV.
Faculty of Medicine, Suez Canal University, Ismaillia, Egypt.|College of Medicine, University of Sharjah, Sharjah, UAE.
A T
AT
El-Serafi
Faculty of Science, Port-Said University, Port-Said, Egypt.
S
S
Osama
Port-Said Tropical Hospital, Port-Said, Egypt.
H
H
El-Zalat
Faculty of Science, Port-Said University, Port-Said, Egypt.
I M
IM
EL-Deen
D000735:Androstenedione / Q000378:metabolism*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism*; D019698:Hepatitis C, Chronic / Q000378:metabolism*; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D012720:Severity of Illness Index; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone; D000735:Androstenedione; D019314:Dehydroepiandrosterone Sulfate; D011388:Prolactin
Androstenedione; dehydroepiandrosterone sulphate; hepatitis C; prolactin; testosterone