Strength and sensation after epidural ropivacaine in men and women.
We injected 15 ml epidural ropivacaine in 30 men and 30 women to determine the median dose required to impair a straight-leg raise. We started at a concentration of 0.425%, increasing the concentration by 0.025% after an ineffective injection and decreasing the concentration by 0.025% after an effective injection. The median (95% CI) concentration of ropivacaine that prevented straight-leg raise within 30 min of injection was 0.43% (0.41-0.45%) in men and 0.40% (0.39-0.41%) in women, p = 0.001. There were no differences in dermatome levels for loss of pinprick and cold sensation between men and women.
Department of Anaesthesiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
S
S
Gan
Department of Anaesthesiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
L
L
Song
Department of Anaesthesiology, Women's Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
W
W
Chen
Department of Anaesthesiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Z
Z
Feng
Department of Anaesthesiology, Shaoxing Peoples' Hospital, Shaoxing, China.
Y
Y
Li
Department of Anaesthesiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
J
J
Zhang
Department of Anaesthesiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
S
S
Zhu
D000293:Adolescent; D000328:Adult; D000368:Aged; D000577:Amides / Q000494:pharmacology*; D000704:Analysis of Variance; D000767:Anesthesia, Epidural / Q000379:methods*; D000779:Anesthetics, Local / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000187:drug effects*; D000077212:Ropivacaine; D012677:Sensation / Q000187:drug effects*; D055815:Young Adult
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine