Ultrasound-guided percutaneous microwave ablation for adenomyosis: efficacy of treatment and effect on ovarian function.
A total of 142 premenopausal women with symptomatic adenomyosis underwent ultrasound (US)-guided percutaneous microwave ablation (PMWA) at the Chinese PLA General Hospital. This study aimed to evaluate changes in serum pituitary, gonadal hormone and cancer antigen 125 (CA125) levels after US-guided PMWA. Therefore, estradiol (E2), follicle-stimulating hormone (FSH), prolactin (PRL) and CA125 levels were evaluated before ablation and at 3, 6, 9 and 12 months after ablation. No significant differences were observed in the E2 and FSH levels pre-ablation and during follow-up (E2: p=0.933, p=0.987, p=0.106, p=0.936; FSH: p=0.552, p=0.295, p=0.414, p=0.760). The mean absolute values of serum CA125 and PRL were significantly decreased at 3, 6, 9 and 12 months after ablation (CA125: p<0.001, p<0.001, p<0.001, p=0.003; PRL: p<0.001, p<0.001, p<0.001, p<0.001). A significant correlation between changes in CA125 levels and uterine volume was found (p<0.001). No evidence of a decline in ovarian function was observed after US-guided PMWA.
1] Department of Interventional Ultrasound, Chinese PLA General Hospital [2] Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University. (This study was performed at Chinese PLA General Hospital).
Yu
Y
Yang
Department of Interventional Ultrasound, Chinese PLA General Hospital.
Jing
J
Zhang
Department of Interventional Ultrasound, Chinese PLA General Hospital.
Zhi-yu
ZY
Han
1] Department of Interventional Ultrasound, Chinese PLA General Hospital [2] Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University. (This study was performed at Chinese PLA General Hospital).
Xia
X
Ma
Department of Interventional Ultrasound, Chinese PLA General Hospital.
Yan-li
YL
Hao
Department of Interventional Ultrasound, Chinese PLA General Hospital.
Chang-tao
CT
Xu
Department of Interventional Ultrasound, Chinese PLA General Hospital.
Rui-fang
RF
Xu
Department of Interventional Ultrasound, Chinese PLA General Hospital.
Bing-song
BS
Zhang
D062788:Adenomyosis / Q000097:blood / Q000503:physiopathology* / Q000628:therapy*; D000328:Adult; D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000097:blood; D008872:Microwaves; D008875:Middle Aged; D010053:Ovary / Q000503:physiopathology*; D016896:Treatment Outcome; D014465:Ultrasonics
D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins