The mRNA expression of the human 1,25-dihydroxyvitamin D3 receptor and the c-myc protooncogene in cultured human keratinocytes.
The human vitamin D receptor mRNA expression in preconfluent human cultured keratinocytes was upregulated by treatment of these cells with 10(-8) M 1,25(OH)2D3 for 24 hours. Additionally, human c-myc mRNA expression was decreased in a dose dependent manner by 1,25(OH)2D3 in both preconfluent and confluent cultured human keratinocytes.
Vitamin D, Skin, and Bone Research Laboratory, Boston University School of Medicine, Boston City Hospital, 80 East Concord Street, M-1013, Boston, Massachusetts 02118, USA.
N M
NM
Hanafin
K S
KS
Persons
M F
MF
Holick
D002117:Calcitriol / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression / Q000187:drug effects; D016259:Genes, myc / Q000235:genetics*; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D012333:RNA, Messenger; D018167:Receptors, Calcitriol / Q000235:genetics*
D012333:RNA, Messenger; D018167:Receptors, Calcitriol; D002117:Calcitriol