Planar polarity: converting a morphogen gradient into cellular polarity.
Epithelial cells are polarized within the apico-basal and planar axes. The latter - planar cell polarity - requires long-range regulation of orientation as well as short-range, cell-to-cell realignment through feedback loops. New insights into the long-range, gradient-type regulation reveal how a kinase translates the morphogen gradient input into cellular orientation.
Department of Developmental & Regenerative Biology, and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Giovanna M
GM
Collu
Department of Developmental & Regenerative Biology, and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: Marek.Mlodzik@mssm.edu.
Marek
M
Mlodzik
D000818:Animals; D004330:Drosophila / Q000033:anatomy & histology*; D029721:Drosophila Proteins / Q000502:physiology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*
D029721:Drosophila Proteins; D008562:Membrane Glycoproteins