[Relationship between clinical features and cognitive function in patients with childhood and adolescence-onset schizophrenia].
OBJECTIVE
To explore the factors influencing cognitive functions in patients with childhood and adolescence-onset schizophrenia.


METHODS
The clinical data of 78 patients with childhood and adolescence-onset schizophrenia who met with the criteria of ICD-10 for schizophrenia were retrospectively reviewed. The cognitive functions were evaluated by the Chinese Wechsler Intelligence Scale for Children (C-WISC), the Wisconsin Card Sorting Test (WCST), digit span backward and P300. The clinical symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS).


RESULTS
The patients with a lower education level or earlier onset of age had a longer P3 latency at the P300Fz area. The patients with a higher parental education level had higher scores of full intelligence quotient (FIQ), verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ), conceptual level and completed categories of WCST and backward numeric order reciting. The patients with higher PANSS negative subscale scores had lower scores of FIQ, VIQ, PIQ, completed categories and conceptual level of WCST and backward numeric order reciting. The patients with a longer stabilization time had higher backward numeric order reciting scores.


CONCLUSIONS
The severity of negative symptoms of the patients and the educational level of their parents are major factors influencing cognitive functions in patients with childhood and adolescence-onset schizophrenia.
Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China. kangbao98@163.com.
Yang
Y
Cao
Chuan-Yuan
CY
Kang
Shuai
S
Wan
Meng-Meng
MM
DU
Kai-Jing
KJ
Ding
Xue-Rong
XR
Li
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D003071:Cognition; D004522:Educational Status; D005260:Female; D006801:Humans; D007360:Intelligence; D016015:Logistic Models; D008297:Male; D012559:Schizophrenia; D012565:Schizophrenic Psychology