Antitumor activity of trigonelline-incorporated chitosan nanoparticles.
In this study, trigonelline, a niacin-related compound was incorporated into chitosan nanoparticles through ion-complex formation between anionic carboxylic acid group of trigonelline and cationic amine group of chitosan. Morphology of trigonelline-incorporated chitosan nanoparticles have spherical shape with less than 500 nm in size and thier size distribution showed quite unimodel phase. Even though trigonelline and trigonelline-incorporated chitosan nanoparticles were not significantly affected to the proliferation of tumor cells, invasion of tumor cells was effectively inhibited by trigonelline-incorporated chitosan nanoparticles. We suggested that trigonelline-incorporated chitosan nanoparticles are promising candidate for inhibition of tumor cell invasion.
Young-Il
YI
Jeong
Da Hye
DH
Kim
Kyu Don
KD
Chung
Yoon Hyuk
YH
Kim
Yeon Soo
YS
Lee
Ki-Choon
KC
Choi
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D048271:Chitosan / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles; D009361:Neoplasm Invasiveness / Q000517:prevention & control
D000470:Alkaloids; D000970:Antineoplastic Agents; C009560:trigonelline; D048271:Chitosan