Alarmins released during local antitumor treatments play an essential role in enhancing tumor growth inhibition at treated and non-treated sites via a derivative of CCL3.
ECI301 (eMIP), a single amino-acid substituted CCL3 (MIP-1α), enhanced tumor growth inhibition and the abscopal effect (an effect distal to the target) following local antitumor therapy such as radiation, radiofrequency ablation (RFA), or hyperthermia treatment. The recent elucidation of the underlying mechanism may lead to a better antitumor therapy.
YU-ECI Research Center for Medical Science; Yeungnam University ; Gyengsan, Gyeungbuk, Republic of Korea.
Shiro
S
Kanegasaki
YU-ECI Research Center for Medical Science; Yeungnam University ; Gyengsan, Gyeungbuk, Republic of Korea.
Tomoko
T
Tsuchiya
CT, computed tomography; ECI301; HMGB1; HMGB1, high mobility group box-1 protein; HSP, heat shock protein; HSP70; MIP-1α; MIP-1α, macrophage inflammatory protein 1α; RFA, radiofrequency ablation; abscopal effect; alarmin; eMIP; hyperthermia; radiation; radiofrequency ablation