Twelve benzene derivatives from Clausena excavata.
A new phenethanol, (2'R)-4-(2', 3'-dihydroxy-3'-methyl-butanoxy)-phenethanol (1), along with other eleven known benzene derivatives (2-12) were isolated from the roots, stems and leaves of Clausena excavata (Rutaceae). Compounds 3 and 4 are new natural products, and compounds 5-8, 10-12 were isolated from C. excavata for the first time. Their structures were elucidated on the basis of MS, 1D and 2D NMR spectroscopic analyses including HSQC, COSY and HMBC experiments. 1 was tested for its cytotoxicities against A549, HeLa and BGC-823 cancer cell lines, and antimicrobial activities against Candida albicans and Staphylococcus aureus. The results showed that 1 did not exhibit cytotoxic and antimicrobial activities.
Wen-Wen
WW
Peng
Wei-Wu
WW
Song
Mao-Bo
MB
Huang
Guang-Zhi
GZ
Zeng
Ning-Hua
NH
Tan
D001555:Benzene Derivatives / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D054700:Clausena / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
D001555:Benzene Derivatives