Association between CEBPE Variant and Childhood Acute Leukemia Risk: Evidence from a Meta-Analysis of 22 Studies.
The CCAAT/enhancer binding proteins (CEBPs) have been involved in the etiology of acute leukemia (AL) and investigated in numerous genetic association studies, however, the results were inconclusive. The current meta-analysis was conducted to clarify the effect of CEBPE rs2239633 variant on childhood AL risk. Electronic literature search was performed on August 15, 2014, from databases of Medline, PubMed, Embase, and Web of Science. A total of 22 case-control studies were eligible for the pooled analysis. The results demonstrated that rs2239633 A allele was significantly associated with a decreased risk of childhood AL (A vs G: OR=0.87, 95%CI = 0.80, 0.94, p<0.001), especially in B-cell ALL subgroup (A vs G: OR = 0.79, 95%CI = 0.74, 0.83, p<0.001), but not among T-cell ALL or AML subgroups. In the stratified analysis by ethnicity, the association was observed in Europeans (A vs G: OR = 0.80, 95%CI = 0.76, 0.84, p<0.001) but not in Asian and mixed populations. Moreover, the results of sensitivity and cumulative meta-analysis indicated the robustness of our results. Also, Begg's and Egger's tests did not indicate any evidence of obvious asymmetry. In summary, our study provided evidence that CEBPE rs2239633 variant is associated with decreased risk of childhood B-cell ALL in Europeans.
Department of Anesthesiology, Huai'an Matenal and Child Health Hospital, Huai'an, Jiangsu, China.
Jian
J
Sun
Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical College, Huai'an, China.
Jinyu
J
Zheng
Department of Neurosurgery, Tongling People's Hospital, Tongling, An'hui, People's Republic of China.
Linjun
L
Tang
Sainte-Justine University Hospital Research Center, Montreal, Quebec, Canada.
Jasmine
J
Healy
Sainte-Justine University Hospital Research Center, Montreal, Quebec, Canada; Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.
Daniel
D
Sinnett
Nanjing Children's Hospital, Affiliated with Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.
Yue-e
YE
Dai
D000208:Acute Disease; D000367:Age Factors; D000483:Alleles; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics*; D002648:Child; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk
D022762:CCAAT-Enhancer-Binding Proteins; C070790:CEBPE protein, human