Genetic variants within the serotonin transporter associated with familial risk for major depression.
The role of the serotonin transporter promoter linked polymorphism (5HTTLPR) in depression, despite much research, remains unclear. Most studies compare persons with and without depression to each other. We show offspring at high (N = 192) as compared to low (N = 101) familial risk for major depressive disorder were almost four times as likely to have two copies of the short allele at 5HTTLPR, suggesting that incorporation of family history could be helpful in identifying genetic differences.
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: talatia@nyspi.columbia.edu.
Ardesheer
A
Talati
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: Guffant@nyspi.columbia.edu.
Guia
G
Guffanti
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA. Electronic address: Odgerel@nyspi.columbia.edu.
Zagaa
Z
Odgerel
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, USA. Electronic address: ii2135@columbia.edu.
Iuliana
I
Ionita-Laza
Department of Child Psychiatry, University of Turku, Turku, Finland. Electronic address: Heli.malm@hus.fi.
Heli
H
Malm
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Department of Child Psychiatry, University of Turku, Turku, Finland. Electronic address: Andsou@utu.fi.
Andre
A
Sourander
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: asb11@columbia.edu.
Alan S
AS
Brown
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: wickramp@nyspi.columbia.edu.
Priya J
PJ
Wickramaratne
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: jag46@columbia.edu.
Jay A
JA
Gingrich
Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA; Sackler Institute for Developmental Psychobiology, Columbia University, New York, NY, USA. Electronic address: mmw3@columbia.edu.
Myrna M
MM
Weissman
D003865:Major Depressive Disorder / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D010375:Pedigree; D011110:Polymorphism, Genetic; D012306:Risk; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D012720:Severity of Illness Index
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
High-risk design; Serotonin transporter linked polymorphic region (5HTTLPR); rs25531