Comparison of the level of intraoperative nociception between laparoscopic and open hepatic resection.
OBJECTIVE
Sufficient suppression of perioperative nociception is important for ensuring favorable postoperative outcomes. Although the level of nociception during laparoscopic surgery is generally lower than during laparotomy, there is insufficient evidence to support this for hepatic resection.


METHODS
To develop a method to retrospectively evaluate the intraoperative nociceptive level, we collected data of intraoperative averaged values of heart rate, perfusion index, systolic blood pressure during three surgeries with different levels of intraoperative nociception. After we validated the utility of discriminant analysis using these variables for the retrospective evaluation of nociception during surgery, we performed this analysis in patients who underwent either laparoscopic or open hepatic resection.


RESULTS
Although there was a significant difference in discriminant score between the open and the laparoscopic hepatic resection groups before propensity score matching, discriminant score showed no significant difference between two groups after matching.


CONCLUSIONS
The level of nociception during laparoscopic hepatic resection is likely similar to that during open hepatic resection. An assertive anti-nociceptive strategy might be required for laparoscopic procedures under general anesthesia, as with open procedures.
Kazuma
K
Hashimoto
Hiroki
H
Miyawaki
Sachiko
S
Iwayama
Nobutaka
N
Kariya
Tsuneo
T
Tatara
Munetaka
M
Hirose
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001794:Blood Pressure; D056805:Consciousness Monitors; D016002:Discriminant Analysis; D005260:Female; D006339:Heart Rate; D006498:Hepatectomy / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D007432:Intraoperative Period; D010535:Laparoscopy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000295:instrumentation / Q000379:methods; D059225:Nociception; D010092:Oximetry; D010991:Plethysmography; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D015203:Reproducibility of Results; D012189:Retrospective Studies; D013997:Time Factors