HIV-1 subtypes and drug resistance profiles in a cohort of heterosexual patients in Istanbul, Turkey.
Turkey is seeing a steady rise in rates of HIV infection in the country. The number of individuals with HIV/AIDS was greater than 7000 in 2014 according to data released by the Ministry of Health, and heterosexual contacts were reported to be the main transmission routes. Istanbul has the highest number of reported cases of HIV infection. The aim of the study was to determine the prevalence of HIV-1 drug resistance in 50 heterosexual patients from Istanbul. The most prevalent subtype was found to be subtype B (56.2 %). Resistance-associated mutations were found in 14 patients with 6/14 patients being therapy-experienced and 8/14 therapy naive at the time point of analysis. With increasing number of patients who require treatment and the rapid up-scaling of the antiretroviral therapy in Turkey, HIV-1 drug resistance testing is recommended before starting treatment in order to achieve better clinical outcomes.
Department of Microbiology and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Muammer Osman
MO
Köksal
Hayati
H
Beka
Nadine
N
Lübke
Jens
J
Verheyen
Haluk
H
Eraksoy
Atahan
A
Cagatay
Rolf
R
Kaiser
Baki
B
Akgül
Ali
A
Agacfidan
D024882:Drug Resistance, Viral; D005787:Gene Frequency; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D020010:Heterosexuality; D020125:Mutation, Missense; D014421:Turkey / Q000453:epidemiology