Association between genetic variants in SLC25A12 and risk of autism spectrum disorders: An integrated meta-analysis.
The solute carrier family 25 (aspartate/glutamate carrier), member 12 gene (SLC25A12) has been strongly posed as a candidate gene for autism spectrum disorder (ASD) given its important role in mitochondrial function and adenosine triphosphate (ATP) synthesis. Evidence is mounting for the association between SLC25A12 variants (rs2056202 and rs2292813) and ASD risk, but the results are inconsistent. To clarify the effect of these two variants on ASD, a meta-analysis integrating case-control and transmission disequilibrium test (TDT) studies was performed. The PubMed, Embase, Cochrane Library, Web of Science, Chinese BioMedical Literature (CBM), Wanfang, and Chinese National Knowledge Infrastructure (CNKI) databases were systematically searched to identify relevant studies published up to May 2014. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated to assess the strength of association. A total of 775 cases, 922 controls, and 1289 families available from 8 studies concerning rs2056202, and 465 cases, 450 controls, and 1516 families available from 7 studies concerning rs2292813 were finally included. In the overall meta-analysis, the rs2056202 T allele and rs2292813 T allele were both significantly associated with a decreased risk of ASD (rs2056202: OR = 0.809, P = 0.001, 95%CI: 0.713-0.917, I(2) = 0.0%, and P(heterogeneity) = 0.526; rs2292813: OR = 0.752, P < 0.001, 95%CI: 0.649-0.871, I(2) = 0.0%, P(heterogeneity) = 0.486). Besides, subjects with T-T haplotype of rs2056202-rs2292813 had a significantly reduced risk of ASD (OR = 0.672, P < 0.001, 95%CI: 0.564-0.801, I(2) = 0.0%, P(heterogeneity) = 0.631). Sensitivity analysis, cumulative meta-analysis, and publication bias diagnostics confirmed the reliability and stability of our results. Our meta-analysis suggests that rs2056202 and rs2292813 in SLC25A12 may contribute significantly to ASD risk.
Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, China.
Jun
J
Liu
Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, China.
Aiping
A
Yang
Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, China.
Qunwei
Q
Zhang
Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, China.
Guohui
G
Yang
Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, China.
Wenjun
W
Yang
Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, China.
Heyue
H
Lei
Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, China.
Jianjun
J
Quan
Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, China.
Fei
F
Qu
Department of Clinical Laboratory, Zhejiang Xiaoshan Hospital, Hangzhou, China.
Min
M
Wang
Department of Paediatrics, Xiaoshan No.1 Hospital Affiliated to Hangzhou Normal University, Hangzhou, China.
Zengyu
Z
Zhang
Zhejiang-California International Nanosystems Institute, Zhejiang University, Hangzhou, China.
Ke
K
Yu
D000067877:Autism Spectrum Disorder / Q000235:genetics*; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D033681:Mitochondrial Membrane Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
D033681:Mitochondrial Membrane Transport Proteins; C114606:SLC25A12 protein, human
ASD; SLC25A12 gene; meta-analysis; polymorphism; susceptibility