Novel mechanism of bioluminescence: oxidative decarboxylation of a moiety adjacent to the light emitter of Fridericia luciferin.
A novel luciferin from a bioluminescent Siberian earthworm Fridericia heliota was recently described. In this study, the Fridericia oxyluciferin was isolated and its structure elucidated. The results provide insight into a novel bioluminescence mechanism in nature. Oxidative decarboxylation of a lysine fragment of the luciferin supplies energy for light generation, while a fluorescent CompX moiety remains intact and serves as the light emitter.
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia) http://yampolsky.ibch.ru.
Maxim A
MA
Dubinnyi
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia) http://yampolsky.ibch.ru.|Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997 (Russia).
Zinaida M
ZM
Kaskova
Laboratory of Photobiology, Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia).
Natalja S
NS
Rodionova
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia) http://yampolsky.ibch.ru.|Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997 (Russia).
Mikhail S
MS
Baranov
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia) http://yampolsky.ibch.ru.|Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Nauki Prosp. 6, Pushchino, 142290 (Russia).
Andrey Yu
AY
Gorokhovatsky
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia) http://yampolsky.ibch.ru.
Alexey
A
Kotlobay
School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332-0400 (USA).
Kyril M
KM
Solntsev
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia) http://yampolsky.ibch.ru.|Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997 (Russia).
Aleksandra S
AS
Tsarkova
Laboratory of Photobiology, Institute of Biophysics, Siberian Branch of the Russian Academy of Sciences, Akademgorodok, Krasnoyarsk 660036 (Russia).
Valentin N
VN
Petushkov
Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, Moscow 117997 (Russia) http://yampolsky.ibch.ru. ivyamp@ibch.ru.|Pirogov Russian National Research Medical University, Ostrovitianov 1, Moscow 117997 (Russia). ivyamp@ibch.ru.
Ilia V
IV
Yampolsky
D000818:Animals; D003653:Decarboxylation; D007211:Indoles / Q000737:chemistry; D049408:Luminescent Agents / Q000737:chemistry*; D008163:Luminescent Measurements; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009835:Oligochaeta / Q000378:metabolism*; D010084:Oxidation-Reduction; D011719:Pyrazines / Q000737:chemistry
D007211:Indoles; D049408:Luminescent Agents; D011719:Pyrazines; C014730:oxyluciferin
bioluminescence; bioorganic chemistry; luciferin; oxidative decarboxylation; peptides