Characteristics and oxidative stress on rats and traffic policemen of ambient fine particulate matter from Shenyang.
Fine particulate matter (PM2.5) pollution is becoming serious in China. This study aimed to investigate the impact of PM2.5 on DNA damage in Shenyang city. The concentration and composition of PM2.5 in traffic policemen's working sites including fields and indoor offices were obtained. Blood samples of field and office policemen were collected to detect DNA damage by Comet assay. Rats were used to further analyzing the oxidative DNA damage. The average concentration of PM2.5 in exposed group was significantly higher than that in control group. Composition analysis revealed that toxic heavy metal and polycyclic aromatic hydrocarbon substances were main elements of this PM2.5. DNA damage in field policemen was significantly higher than those in non-field group. Moreover, animal studies confirmed the oxidative DNA damage induced by PM2.5. Taken together, high DNA damages are found in the Shenyang traffic policemen and rats exposed to high level of airborne PM2.5.
Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, Liaoning Province 110034, Peoples Republic of China.
Mingyue
M
Ma
Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, Liaoning Province 110034, Peoples Republic of China.
Shuyin
S
Li
Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, Liaoning Province 110034, Peoples Republic of China.
Huanrong
H
Jin
Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, Liaoning Province 110034, Peoples Republic of China.
Yumin
Y
Zhang
Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, Liaoning Province 110034, Peoples Republic of China.
Jia
J
Xu
Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, Liaoning Province 110034, Peoples Republic of China.
Dongmei
D
Chen
Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, Liaoning Province 110034, Peoples Republic of China.
Chen
C
Kuimin
Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, Liaoning Province 110034, Peoples Republic of China.
Zhou
Z
Yuan
Department of Toxicology, School of Public Health, Shenyang Medical College, Shenyang, Liaoning Province 110034, Peoples Republic of China. Electronic address: xiaochunling2000@163.com.
Chunling
C
Xiao
D000393:Air Pollutants / Q000032:analysis*; D000397:Air Pollution / Q000706:statistics & numerical data*; D000818:Animals; D002681:China; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D052638:Particulate Matter / Q000032:analysis*; D016495:Police; D051381:Rats; D014504:Urban Health; D001335:Vehicle Emissions / Q000032:analysis
D000393:Air Pollutants; D052638:Particulate Matter; D001335:Vehicle Emissions
DNA damage; Fine particulate matter; Oxidative stress; Polycyclic aromatic hydrocarbon