Computational prediction of Escherichia coli proteins host subcellular targeting and their implications in colorectal cancer etiology.
Recent evidences indicate potential Escherichia coli involvement in colorectal cancer etiology. Colorectal cancer cells are exclusively colonized by enteroinvasive E. coli, which regulates several factors that can affect colorectal cancer progression in susceptible individuals. Earlier, we predicted nuclear targeting of E. coli proteins and their role in colorectal cancer etiology. In this study, we predict targeting of E. coli proteins in host cell mitochondria and cytoplasm and their role in colorectal cancer. Several important biological processes are regulated in the cell cytoplasm and mitochondria, where the targeting of E. coli proteins may have several possible implications. A total of 87/561 and 315/561 E. coli proteins were found to target host cell mitochondria and cytoplasm respectively. These include several proteins with the ability to influence normal growth behavior. The current article provides an outline for E. coli protein targeting in host cells and suggests that these proteins can contribute to the colorectal cancer etiology through a variety of strategies.
Nanomedicine Research Unit, Department of Pharmaceutics, College of Pharmacy, PO Box 2457, King Saud University, Riyadh 11451, Saudi Arabia; College of Life Sciences, Cancer Hospital & Research Institute, Gwalior, MP 474009, India. Electronic address: abdularifkhan@gmail.com.
Abdul Arif
AA
Khan
Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.
Zakir
Z
Khan
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Abdul
A
Malik
College of Life Sciences, Cancer Hospital & Research Institute, Gwalior, MP 474009, India.
Abhinav
A
Shrivastava
Department of Microbiology, Vikram University, Ujjain, MP, India.
Sudhir K
SK
Jain
Nanomedicine Research Unit, Department of Pharmaceutics, College of Pharmacy, PO Box 2457, King Saud University, Riyadh 11451, Saudi Arabia; King Abdullah Institute for Nanotechnology, King Saud University, P.O.Box 2455, Riyadh 11451, Saudi Arabia.
Aws
A
Alshamsan
D015179:Colorectal Neoplasms / Q000382:microbiology*; D019295:Computational Biology; D029968:Escherichia coli Proteins / Q000378:metabolism*; D006801:Humans; D013347:Subcellular Fractions / Q000378:metabolism*
D029968:Escherichia coli Proteins
Chronic infection; Colon cancer; Escherichia coli; In silico; Protein targeting