Integrating innate and adaptive immune cells: Mast cells as crossroads between regulatory and effector B and T cells.
A diversity of immune mechanisms have evolved to protect normal tissues from infection, but from immune damage too. Innate cells, as well as adaptive cells, are critical contributors to the correct development of the immune response and of tissue homeostasis. There is a dynamic "cross-talk" between the innate and adaptive immunomodulatory mechanisms for an integrated control of immune damage as well as the development of the immune response. Mast cells have shown a great plasticity, modifying their behavior at different stages of immune response through interaction with effector and regulatory populations of adaptive immunity. Understanding the interplays among T effectors, regulatory T cells, B cells and regulatory B cells with mast cells will be critical in the future to assist in the development of therapeutic strategies to enhance and synergize physiological immune-modulator and -suppressor elements in the innate and adaptive immune system.
The Herbert Mast Cell Disorders Center, Department of Medicine, Meir Medical Center, Kfar Saba and the Sackler School of Medicine, Tel Aviv University, Israel. Electronic address: ymekori@gmail.com.
Yoseph A
YA
Mekori
The Herbert Mast Cell Disorders Center, Department of Medicine, Meir Medical Center, Kfar Saba and the Sackler School of Medicine, Tel Aviv University, Israel.
Alon Y
AY
Hershko
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy.
Barbara
B
Frossi
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy.
Francesca
F
Mion
Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy. Electronic address: carlo.pucillo@uniud.it.
Carlo E
CE
Pucillo
D056704:Adaptive Immunity; D000818:Animals; D060151:B-Lymphocytes, Regulatory / Q000166:cytology*; D002450:Cell Communication; D006801:Humans; D007113:Immunity, Innate; D008407:Mast Cells / Q000166:cytology*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology*
B cells; B reg cells; Mast cell; T effector cells; T reg cells