Markers of bone remodeling are associated with arterial stiffness in renal transplanted subjects.
BACKGROUND
Bone-vessel interaction in chronic renal failure remains poorly understood and could be driven by bone remodeling factors including osteoprotegerin (OPG), fibroblast growth factor 23 (FGF23), parathormone and vitamin D. Only few data are available in renal transplantation. The aim of this study was to investigate the relationship between bone remodeling factors and large artery function in renal transplant patients.


METHODS
89 renal transplant patients were enrolled in this cross-sectional study. Carotid to femoral pulse wave velocity (PWV) and central augmentation index (AIx) were determined as an estimation of large artery function. Blood samples were collected for measurement of vascular risk markers. Independent predictors were identified by multivariate linear regression through backward feature selection using Akaike's information criteria.


RESULTS
At multivariate analysis, age (p < 0.001) and systolic arterial pressure (p = 0.003) were significantly associated with PWV but not AIx. In addition, both elevated blood concentrations of 1.25(OH)2 vitamin D (p = 0.013) and OPG (p = 0.047) were still significantly related to high PWV.


CONCLUSIONS
These results underline that age and mean arterial pressure are the main determinants of PWV following renal transplantation. Among bone remodeling biomarkers, plasma OPG and active vitamin D were the strongest determinants of arterial stiffness.
Laboratoire de Biochimie, CHRU Montpellier, Univ Montpellier 1, Montpellier, France.|PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295, Montpellier Cedex 5, France.
Anne-Sophie
AS
Bargnoux
Service de Néphrologie et Transplantation, CHRU Montpellier, Univ Montpellier 1, Montpellier, France.
Fernando
F
Vetromile
Laboratoire de Biochimie, CHRU Montpellier, Univ Montpellier 1, Montpellier, France.|PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295, Montpellier Cedex 5, France.
Nils
N
Kuster
Laboratoire de Biochimie, CHRU Montpellier, Univ Montpellier 1, Montpellier, France.
Julie
J
Barberet
Laboratoire de Biochimie, CHRU Montpellier, Univ Montpellier 1, Montpellier, France.
Anne-Marie
AM
Dupuy
Service de Médecine Interne, CHRU Montpellier, Univ Montpellier 1, Montpellier, France.
Jean
J
Ribstein
Service de Néphrologie et Transplantation, CHRU Montpellier, Univ Montpellier 1, Montpellier, France.
Georges
G
Mourad
Laboratoire de Biochimie, CHRU Montpellier, Univ Montpellier 1, Montpellier, France. jp-cristol@chu-montpellier.fr.|PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295, Montpellier Cedex 5, France. jp-cristol@chu-montpellier.fr.|Department of Biochemistry, Lapeyronie University Hospital, 191 Avenue du Doyen Gaston Giraud, 34295, Montpellier Cedex 5, France. jp-cristol@chu-montpellier.fr.
Jean-Paul
JP
Cristol
Service de Médecine Interne, CHRU Montpellier, Univ Montpellier 1, Montpellier, France.
Pierre
P
Fesler
D000328:Adult; D000367:Age Factors; D062186:Arterial Pressure; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling; D002339:Carotid Arteries / Q000503:physiopathology; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D000089703:Fibroblast Growth Factor-23; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D063177:Pulse Wave Analysis; D059289:Vascular Stiffness; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
D015415:Biomarkers; C000717427:FGF23 protein, human; D053244:Osteoprotegerin; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D000089703:Fibroblast Growth Factor-23
Arterial stiffness; Osteoprotegerin; Renal transplantation; Vitamin D