Anti-obesity effect of Triticum aestivum sprout extract in high-fat-diet-induced obese mice.
Obesity is a common disease worldwide that often results in serious conditions including hypertension, diabetes, and hyperlipidemia. Many herbal medicines have been examined with regard to ameliorating obesity. We investigated the anti-obesity effects of 50% EtOH extract of Triticum aestivum sprout (TAEE) in high-fat-diet (HFD)-induced obese mice. TAEE administration (10, 50, or 200 mg/kg) for 6 weeks significantly decreased the body weights, serum total cholesterol (TC), and low-density lipoprotein cholesterol levels in HFD-fed mice. TAEE treatment reduced lipid accumulation in epididymal white adipose tissue (EWAT) and liver. Moreover, TC and lipid levels were decreased by TAEE treatment in liver. Serum leptin and adiponectin concentrations were reduced by TAEE treatment. TAEE-treated mice showed decreases in peroxisome proliferator-activated receptor γ (PPARγ) and fatty acid synthase expression in EWAT. Furthermore, TAEE administration elevated levels of PPARα protein in the liver of HFD-induced obese mice. These results suggest that TAEE supplementation might be beneficial for the treatment and prevention of obesity and related diseases.
a Department of Oriental Pharmacy , College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University , Iksan , Korea.
Ji-Young
JY
Im
Hyeon-Hui
HH
Ki
Mingjie
M
Xin
Se-Uk
SU
Kwon
Young Ho
YH
Kim
Dae-Ki
DK
Kim
Sun-Pyo
SP
Hong
Jong-Sik
JS
Jin
Young-Mi
YM
Lee
D052242:Adiponectin / Q000097:blood; D052436:Adipose Tissue, White / Q000187:drug effects; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements; D004435:Eating / Q000187:drug effects; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000178:diet therapy* / Q000209:etiology; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D014908:Triticum / Q000737:chemistry* / Q000254:growth & development
D052242:Adiponectin; C499919:Adipoq protein, mouse; D019440:Anti-Obesity Agents; D001786:Blood Glucose; D020738:Leptin; D008055:Lipids; D010936:Plant Extracts
PPARγ; Triticum aestivum; high-fat diet; leptin; obesity