Chemopreventive effects of 5-amino salicylic acids on inflammatory bowel disease-associated colonic cancer and colonic dysplasia: a meta-analysis.
OBJECTIVE
To study the effects of 5-amino salicylic acids (5-ASAs) on the incidence rates of inflammatory bowel disease (IBD)-associated colonic cancer (IBDACa) and colonic dysplasia (IBDADys), as well as to evaluate the chemopreventive effects of 5-ASAs on IBDACa/Dys.


METHODS
Searches for officially published clinical studies on the effects of 5-ASAs on the chemoprevention of IBDACa/Dys were conducted in both foreign-language databases, including PubMed (Medline), EMCC, OVID, and the Cochrane Library, and Chinese databases, including Wanfang, Weipu (VIP), and CNKI, as well as using Google Scholar. For literature matching the selection criteria, the statistical software RevMan was employed to calculate odds ratio (OR) values and 95% confidence intervals (CIs). Sub-group analysis was performed for different study design types and IBD types.


RESULTS
A total of fourteen papers were included in this study. The results of the analysis showed that compared with patients not using 5-ASAs, patients using 5-ASAs showed only 49% of the occurrence rate of IBDACa and IBDADys, OR = 0.49 (95% CI: 0.33-0.73). The OR of ulcerative colitis (UC) patients using 5-ASAs exhibiting UCCa/Dys was 0.44 (95% CI: 0.26-0.76).


CONCLUSIONS
The use of 5-ASAs exerts a chemopreventive effect against IBDACa/Dys.
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University No. 301 Yanchang Road, Shanghai 200072, China.
Xiaorong
X
Xu
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University No. 301 Yanchang Road, Shanghai 200072, China.
Xuanfu
X
Xu
Department of Internal Medicine, The Second People's Hospital of Tibet Autonomous Region Lhasa, China.
Yangzong
Y
Ciren
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University No. 301 Yanchang Road, Shanghai 200072, China.
Baisui
B
Feng
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University No. 301 Yanchang Road, Shanghai 200072, China.
Chunhua
C
Tao
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University No. 301 Yanchang Road, Shanghai 200072, China.
Yujing
Y
Xia
Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University No. 301 Yanchang Road, Shanghai 200072, China.
Zhanju
Z
Liu
5-Amino salicylic acids; Crohn’s disease; chemoprevention; colon cancer; dysplasia; inflammatory bowel disease; meta-analysis; ulcerative colitis