Virulence and Antibiotic Resistance of Pseudomonas aeruginosa Isolated from Patients with Urinary Tract Infections in Southern Poland.
BACKGROUND
The aim of this study was to analyze the resistance and virulence of Pseudomonas aeruginosa strains causing urinary tract infections in in- and outpatients in Southern Poland.


METHODS
The study included 83 inpatients and 66 outpatients; 36.9% were female.


RESULTS
Monomicrobial infections accounted for 74.5%; polymicrobial infections occurred more frequently among inpatients (odds ratio, OR = 4.32, p = 0.0008). exoS and lasB were detected in 90 and 74% of isolates, respectively. aprA was present in 66%, pilB in 5% and pilA in 23% of isolates. Isolates from adults were more frequently resistant to fluoroquinolones (OR = 0.37, p = 0.029). Twenty-nine isolates were classified as multidrug resistant and 12 as extremely drug resistant, which occurred less frequently in patients <17 years (OR = 0.18, p = 0.024). Nine metallo-β-lactamase-positive isolates were identified. blaSHV was present in 10, blaTEM in 6, blaOXA-10 in 3 and blaVIM-2 in 3 isolates.


CONCLUSIONS
Antibiotic selection should be based on the knowledge of local antimicrobial susceptibilities to maximize the benefit for patients and minimize the risk of drug resistance.
Department of Microbiology, Jagiellonian University Medical College, Krakow, Poland.
Monika
M
Pobiega
Jadwiga
J
Wojkowska-Mach
Joanna
J
Maciag
Agnieszka
A
Chmielarczyk
Dorota
D
Romaniszyn
Monika
M
Pomorska-Wesolowska
Grzegorz
G
Ziolkowski
Piotr B
PB
Heczko
Malgorzata
M
Bulanda
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000188:drug therapy / Q000652:urine*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity*; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy / Q000652:urine*; D014774:Virulence / Q000187:drug effects / Q000502:physiology
D000900:Anti-Bacterial Agents