[Applying of recombinant interleukin-1β to treat chronic hepatitis C for patients non-response to the previous antiviral therapy].
The search for rational treatment of CHC patients, non-response to the primary antiviral therapy especially with unfavorable genotypes for interleukin-28B, remains valid.


OBJECTIVE
To evaluate the efficacy and safety of recombinant IL-1β (Betaleukin) in combined antiviral therapy in patients with chronic hepatitis C who did not respond to previous treatment. The study included 26 patients with HCV-1. Patients were divided into 2 groups depending on retreatment scheme: group 1 (n = 10) was treated with recombinant IFN-a2b ("Interal"-P) 5 million IU daily subcutaneously for 12 weeks then every other day until the end of treatment; ribavirin, depending on body weight (800-1200 mg/day) and "Betaleukin" subcutaneously 0.005 mcg/kg every other day for 12 weeks (45 injections); group 2 (n = 16)--recombinant IFN-a2b ("Interal"-P) 3 million IU every other day subcutaneously for 48 weeks; ribavirin--1000 mg/day (for a body weight < 75 kg), 1200 mg/day (for a body weight > 75 kg) and "Betaleukin" subcutaneously 0.005 mcg/kg every other day, five courses for 3 weeks (50 injections).


RESULTS
Combined antiviral therapy (α-IFN2b and RIB) with IL-1β (Betaleukin) in patients who had not responded to previous therapy, with a predominance of unfavorable genetic background for IL-28B typing helped to improve SVR (44%) with more efficient 45-day administration of the medications in the first 12 weeks in combination with inductive α-IFN therapy and achieve biochemical response at week 24 of treatment. Adverse effects of the IL-1β mainly limited with fever, moderate local reactions and do not require discontinuation of treatment.
V Kh
VKh
Fazylov
S V
SV
Tkacheva
É R
ÉR
Manapova
D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D053583:Interleukin-1beta / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008111:Liver Function Tests; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D012254:Ribavirin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome; D019562:Viral Load
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D053583:Interleukin-1beta; D011994:Recombinant Proteins; D012254:Ribavirin