Silver Nanoparticle Coated Bioactive Glasses--Composites with Dex/CMC Hydrogels: Characterization, Solubility, and In Vitro Biological Studies.
Silver (Ag) coated bioactive glass particles (Ag-BG) were formulated and compared to uncoated controls (BG) in relation to glass characterization, solubility and microbiology. X-ray diffraction (XRD) confirmed a crystalline AgNP surface coating while ion release studies determined low Ag release (<2 mg/L). Cell culture studies presented increased cell viability (127 and 102%) with lower liquid extract (50 and 100 ml/ml) concentrations. Antibacterial testing of Ag-BG in E. coli, S. epidermidis and S. aureus significantly reduced bacterial cell viability by 60-90%. Composites of Ag-BG/CMC-Dex Hydrogels were formulated and characterized. Agar diffusion testing was conducted where Ag-BG/hydrogel composites produced the largest inhibition zones of 7 mm (E. coli), 5 mm (S. aureus) and 4 mm (S. epidermidis).
Inamori School of Engineering, Alfred University, Alfred, New York, 14802, USA. wren@alfred.edu.
Anthony W
AW
Wren
Inamori School of Engineering, Alfred University, Alfred, New York, 14802, USA.
Pegah
P
Hassanzadeh
Inamori School of Engineering, Alfred University, Alfred, New York, 14802, USA.
Lana M
LM
Placek
Inamori School of Engineering, Alfred University, Alfred, New York, 14802, USA.
Timothy J
TJ
Keenan
School of Materials Engineering, Purdue University, West Lafayette, Indiana, USA.
Aisling
A
Coughlan
Inamori School of Engineering, Alfred University, Alfred, New York, 14802, USA.
Lydia R
LR
Boutelle
Department of Mechanical & Industrial Engineering, Ryerson University, Toronto, Canada.|Department of Biomedical Engineering, University Malaya, Kuala Lumpur, Malaysia.
Mark R
MR
Towler
D002470:Cell Survival / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D005139:Eyeglasses; D020100:Hydrogels / Q000737:chemistry* / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D014961:X-Ray Diffraction
D020100:Hydrogels; D012834:Silver
bacteria; bioactive glass; hydrogel; ion release; silver