Synthesis and QSAR study of novel anti-inflammatory active mesalazine-metronidazole conjugates.
Novel, mesalazine, metronidazole conjugates 6a-e with amino acid linkers were synthesized utilizing benzotriazole chemistry. Biological data acquired for all the novel bis-conjugates showed (a) some bis-conjugates exhibit comparable anti-inflammatory activity with parent drugs and (b) the potent bis-conjugates show no visible stomach lesions. 3D-pharmacophore and 2D-QSAR modeling support the observed bio-properties.
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, United States.
Roman N
RN
Naumov
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, United States. Electronic address: sspanda12@gmail.com.
Siva S
SS
Panda
Pesticide Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.
Adel S
AS
Girgis
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Riham F
RF
George
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, United States.
Michel
M
Farhat
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, United States; Chemistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Alan R
AR
Katritzky
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D007213:Indomethacin / Q000633:toxicity; D019804:Mesalamine / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D008795:Metronidazole / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship; D013276:Stomach Ulcer / Q000139:chemically induced
D000893:Anti-Inflammatory Agents; D008795:Metronidazole; D019804:Mesalamine; D007213:Indomethacin
Amino acids; Anti-inflammatory; Conjugates; Mesalazine; Metronidazole; QSAR