Obstructive sleep apnea syndrome susceptible genes in the Chinese population: a meta-analysis of 21 case-control studies.
BACKGROUND
Numbers of single nucleotide polymorphisms (SNPs) were identified as risk factors for obstructive sleep apnea syndrome (OSAS) in the Chinese population; however, published articles drew incompatible or even contradictory results.


OBJECTIVE
The aim of this study was to investigate the susceptible SNPs and risk of OSAS in the Chinese population.


METHODS
We conducted a meta-analysis of seven polymorphisms and risk of OSAS based on 21 case-control studies.


RESULTS
The results of our study showed that tumor necrosis factor-α (TNF-α) -308 G/A (OR = 3.70, 95 % CI = 1.39-9.83), gene-linked polymorphic region (LPR) (OR = 0.57, 95 % CI = 0.41-0.79), and variable number tandem repeat (VNTR) of the 5-hydroxytryptamine transporter gene (5-HTT) (OR = 3.44, 95 % CI = 1.49-7.95) polymorphisms were associated with OSAS risk in the Chinese population, while there was no significant association between 5-hydroxytryptamine 2A receptor (5-HTR2A) 102C/T, 5-HTR2A A1438G, angiotensin-converting enzyme (ACE) insertion (I)/deletion (D), or leptin receptor (LEPR)-Gln 223Arg polymorphism and risk of OSAS in the Chinese population.


CONCLUSIONS
Our study demonstrated that TNF-α 308 G/A, 5-HTT LPR, and 5-HTT-VNTR polymorphisms were associated with OSAS risk, whereas little association was observed between 5-HTR2A 102C/T, 5-HTR2A A1438G, ACE I/D, or LEPR-Gln 223Arg polymorphism and risk of OSAS in the Chinese population.
Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, College of Medicine and Institute of Respiratory Diseases, Zhejiang University, Hangzhou, 310009, China.
Fen
F
Lan
Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, College of Medicine and Institute of Respiratory Diseases, Zhejiang University, Hangzhou, 310009, China.|Department of Respiratory Medicine, Affiliated Hospital of School of Medicine, Ningbo University, Ningbo, 315020, China.
Chao
C
Cao
Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, College of Medicine and Institute of Respiratory Diseases, Zhejiang University, Hangzhou, 310009, China.
Jinkai
J
Liu
Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, College of Medicine and Institute of Respiratory Diseases, Zhejiang University, Hangzhou, 310009, China. liwenhz@163.com.
Wen
W
Li
D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D020181:Sleep Apnea, Obstructive / Q000235:genetics*
Chinese; Meta-analysis; Obstructive sleep apnea syndrome; Polymorphism