An update on clinical applications of electrospun nanofibers for skin bioengineering.
Mimicking morphological similarities of the natural extra cellular matrix (ECM), described by ultrafine continuous fibers, high surface to volume ratio, and high porosity is valuable for effective regeneration of injured skin tissue. Electrospun nanofibers, being one of the most favorable and fast developing products of technology today, display a tremendous potential in wound healing and skin tissue engineering. Under the remarkable attention being given to electrospun nanofibrous scaffolds in promoting wound healing and skin regeneration, this review focuses on the potential of the electrospinning technique as a promising tool for constructing polymeric nanofibrous scaffolds with the favorable physicochemical properties needed for skin bioengineering. In addition, current applications of electrospun nanofibrous matrices for skin bioengineering are detailed in this review.
a Stem Cell Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Hematology and Oncology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Yones
Y
Pilehvar-Soltanahmadi
a Stem Cell Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|d Department of Medical Biotechnology , and Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
Abolfazl
A
Akbarzadeh
d Department of Medical Biotechnology , and Medical Nanotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
Nasim
N
Moazzez-Lalaklo
a Stem Cell Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Hematology and Oncology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|c Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Nosratollah
N
Zarghami
D000818:Animals; D005109:Extracellular Matrix / Q000737:chemistry*; D006801:Humans; D057139:Nanofibers / Q000737:chemistry*; D012867:Skin; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014945:Wound Healing
electrospinning; extracellular matrix; nanofibrous scaffold; skin bioengineering