Mechanisms of transfer of bioactive molecules through the cell membrane by electroporation.
A short review of biophysical mechanisms for electrotransfer of bioactive molecules through the cell membrane by using electroporation is presented. The concept of transient hydrophilic aqueous pores and membrane electroporation mechanisms of single cells and cells in suspension models are analyzed. Alongside the theoretical approach, some peculiarities of drug and gene electrotransfer into cells and applications in clinical trials are discussed.
Biophysical Research Group, Department of Biology, Faculty of Natural Sciences, Vytautas Magnus University, Vileikos 8, 44404, Kaunas, Lithuania, mive@gmf.vdu.lt.
Mindaugas S
MS
Venslauskas
Saulius
S
Šatkauskas
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism*; D002463:Cell Membrane Permeability; D018274:Electroporation; D006801:Humans; D009930:Organic Chemicals / Q000493:pharmacokinetics
D009930:Organic Chemicals