Myocardial deformation and total atrial conduction time in the prediction of cardiac involvement in patients with pulmonary sarcoidosis.
OBJECTIVE
In this study, we aim to evaluate the left atrial global longitudinal strain (LAGLS), total atrial conduction time (TACT) and left ventricle (LV) functions in recently diagnosed pulmonary sarcoidosis (PS) patients.


METHODS
Fifty recently diagnosed PS patients (group 1) and a control group of 50 healthy individuals (group 2) were evaluated in the study. Two-dimensional echocardiography images were obtained from LV apical 4-chamber (4C), long-axis (L) and 2-chamber (2C) views. Peak longitudinal strain and strain rate (SR) were obtained from 4C, L and 2C views. Mean values of the three views were calculated. LV global longitudinal strain and LV-SR torsion were determined as the net differences in the mean rotation between the apical and basal levels. LAGLS and TACT values were calculated.


RESULTS
The study found that LAGLS was significantly lower in group 1 than in group 2 (P < 0.05). TACT was also significantly longer in group 1 than in group 2 (respectively group 1: 111.6 ± 15.1 ms; group 2: 103.4 ± 5.8 ms, P < 0.001). There was a significant moderate negative correlation between LAGLS and TACT (r = -0.36, P < 0.05). Patients with sarcoidosis had significantly lower LV longitudinal strain and SR measurements than the control group. Although LV basal rotation (LVR) values were similar in both groups, LVR-apical and LV-torsion (LVTR) values were significantly higher in the patient group (group 1).


CONCLUSIONS
The identification of left atrial and left ventricular myocardial deformation using speckle tracking echocardiography in patients with PS allows subclinical LV dysfunction and subclinical electrophysiologic changes to be detected earlier.
Faculty of Medicine, Cardiology, Erzincan University, Erzincan, Turkey.
Hüsnü
H
Değirmenci
Department of Cardiology, Education and Research Hospital, Erzurum, Turkey.
Selami
S
Demirelli
Faculty of Medicine, Cardiology, Gaziosmanpasa University, Tokat, Turkey.
Arif
A
Arısoy
Department of Cardiology, Education and Research Hospital, Erzurum, Turkey.
Emrah
E
Ermiş
Faculty of Medicine, Pulmonary of Disease, Ataturk University, Erzurum, Turkey.
Ömer
Ö
Araz
Faculty of Medicine, Cardiology, Erzincan University, Erzincan, Turkey.
Eftal Murat
EM
Bakırcı
Faculty of Medicine, Cardiology, Erzincan University, Erzincan, Turkey.
Hikmet
H
Hamur
Faculty of Medicine, Cardiology, Erzincan University, Erzincan, Turkey.
Mutlu
M
Büyüklü
Faculty of Medicine, Cardiology, Erzincan University, Erzincan, Turkey.
Ergün
E
Topal
D000328:Adult; D016022:Case-Control Studies; D004452:Echocardiography; D005260:Female; D006325:Heart Atria / Q000002:abnormalities / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D018487:Ventricular Dysfunction, Left / Q000473:pathology / Q000503:physiopathology
atrial conduction; atrial strain; mortality; pulmonary sarcoidosis