A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin gene: A case report in Japan.
Methicillin-resistant Staphylococcus aureus (MRSA) has now been recognized as a common pathogen in the community. Sequence type (ST) 398 MRSA is generally considered as an emerging zoonotic agent spreading among livestock and personnel who have direct contact with animals, mainly in Europe. A 37-year-old Chinese woman receiving steroid therapy for systemic lupus erythematosus with general fatigue and myalgia was brought to the emergency department in critical condition. Her condition deteriorated despite aggressive management and she died on day 7. Her blood culture revealed ST398 MRSA-SCCmec V with Panton-Valentine Leukocidin (PVL) gene. This is the first case report of a fatal infection caused by this lineage. According to the results of molecular analyses, the isolate from this particular patient's blood was genetically close to a lineage detected in China, and is less likely to be related to an animal-associated lineage.
Department of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Hiroshi
H
Koyama
Department of Anesthesiology and Critical Care Medicine, Jichi Medical University Saitama Medical Center, Saitama, Japan. Electronic address: msanui@mac.com.
Masamitsu
M
Sanui
Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo, Japan.
Tomoo
T
Saga
Department of Infectious Diseases, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Sohei
S
Harada
Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo, Japan.
Yoshikazu
Y
Ishii
Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo, Japan.
Kazuhiro
K
Tateda
Department of Surgery, Jichi Medical University, Tochigi, Japan.
Alan Kawarai
AK
Lefor
D000328:Adult; D001427:Bacterial Toxins / Q000235:genetics*; D002681:China; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D005098:Exotoxins / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007564:Japan; D007956:Leukocidins / Q000235:genetics*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics*; D013203:Staphylococcal Infections
D001427:Bacterial Toxins; D004269:DNA, Bacterial; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin
Livestock; Methicillin-resistant Staphylococcus aureus; Panton-Valentine leukocidin