EBV-associated lymphoepithelioma-like carcinoma of the pancreas: Case report with targeted sequencing analysis.
Lymphoepithelioma-like carcinomas are distinctive epithelial derived malignant neoplasms that have a syncytial growth pattern and lymphoid stroma. The majority of tumors with this appearance are Epstein Barr virus (EBV)-associated. We report a patient with a clinical presentation concerning for lymphoma who was diagnosed with an EBV-associated pancreatic carcinoma with a lymphoepithelioma-like pattern. Targeted sequencing analysis showed a molecular profile distinct from conventional ductal adenocarcinoma of the pancreas.
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Rashmi T
RT
Samdani
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jaclyn F
JF
Hechtman
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Eileen
E
O'Reilly
Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ronald
R
DeMatteo
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: sigelc@mskcc.org.
Carlie S
CS
Sigel
D014408:Biomarkers, Tumor / Q000235:genetics*; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics / Q000821:virology*; D004252:DNA Mutational Analysis; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000821:virology*
D014408:Biomarkers, Tumor
EBV-associated carcinoma; Epstein Barr virus; Lymphoepithelial-like carcinoma; Lymphoepithelioma-like carcinoma; Pancreas carcinoma; Targeted molecular analysis