Initiation of renal replacement therapy in the intensive care unit in Vicenza (IRRIV) score.
BACKGROUND
One of the top research priorities in acute kidney injury is related to the timing of renal replacement therapy (RRT) initiation. The purpose was to develop an index that might serve as a standardized concept of timing of initiation of RRT.


METHODS
A previously described database was used. We applied a multivariable Cox regression model with backward selection to characterize parameters present in those patients who received RRT compared with those who did not receive RRT.


RESULTS
We studied 590 patients. We identified independent risk factors for RRT and a risk score was devised. The Area Under the Curve of the receiver operating characteristic curve was 0.81 (95% CI 0.74-0.86) for predicting the need for RRT.


CONCLUSIONS
We have developed a simple Score (IRRIV Score) to identify patients at high risk of requiring RRT. This score may serve as a standardized definition of the timing of initiation of RRT.
Jose J
JJ
Zaragoza
Gianluca
G
Villa
Francesco
F
Garzotto
Aashish
A
Sharma
Anna
A
Lorenzin
Leonardo
L
Ribeiro
Renhua
R
Lu
Rinaldo
R
Bellomo
Claudio
C
Ronco
D058186:Acute Kidney Injury / Q000473:pathology / Q000628:therapy*; D000368:Aged; D019540:Area Under Curve; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012372:ROC Curve; D017582:Renal Replacement Therapy; D012107:Research Design; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D061665:Time-to-Treatment