Diffusivity signatures characterize trigeminal neuralgia associated with multiple sclerosis.
BACKGROUND
Trigeminal neuralgia secondary to multiple sclerosis (MS-TN) is a facial neuropathic pain syndrome similar to classic trigeminal neuralgia (TN). While TN is caused by neurovascular compression of the fifth cranial nerve (CN V), how MS-related demyelination correlates with pain in MS-TN is not understood.


OBJECTIVE
We aim to examine diffusivities along CN V in MS-TN, TN, and controls in order to reveal differential neuroimaging correlates across groups.


METHODS
3T MR diffusion weighted, T1, T2 and FLAIR sequences were acquired for MS-TN, TN, and controls. Multi-tensor tractography was used to delineate CN V across cisternal, root entry zone (REZ), pontine and peri-lesional segments. Diffusion metrics including fractional anisotropy (FA), and radial (RD), axial (AD), and mean diffusivities (MD) were measured from each segment.


RESULTS
CN V segments showed distinctive diffusivity patterns. The TN group showed higher FA in the cisternal segment ipsilateral to the side of pain, and lower FA in the ipsilateral REZ segment. The MS-TN group showed lower FA in the ipsilateral peri-lesional segments, suggesting differential microstructural changes along CN V in these conditions.


CONCLUSIONS
The study demonstrates objective differences in CN V microstrucuture in TN and MS-TN using non-invasive neuroimaging. This represents a significant improvement in the methods currently available to study pain in MS.
Institute of Medical Science and Department of Surgery, University of Toronto, Toronto, ON, Canada/Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada.
David Q
DQ
Chen
Institute of Medical Science and Department of Surgery, University of Toronto, Toronto, ON, Canada/Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada.
Danielle D
DD
DeSouza
Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada.
David J
DJ
Hayes
Institute of Medical Science and Department of Surgery, University of Toronto, Toronto, ON, Canada/Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada.
Karen D
KD
Davis
Division of Neurology, St. Michael's Hospital, University of Toronto, ON, Canada.
Paul
P
O'Connor
Institute of Medical Science and Department of Surgery, University of Toronto, Toronto, ON, Canada/Division of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada/Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, Toronto, ON, Canada mojgan.hodaie@uhn.on.ca.
Mojgan
M
Hodaie
D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology*; D014276:Trigeminal Nerve / Q000473:pathology*; D014277:Trigeminal Neuralgia / Q000209:etiology / Q000473:pathology*
Multiple sclerosis; brain; diffusion tensor imaging; high angular resolution diffusion imaging; magnetic resonance imaging; microstructural; pain; structural; tractography; trigeminal neuralgia