Muscle LIM Protein: Master regulator of cardiac and skeletal muscle functions.
Muscle LIM Protein (MLP) has emerged as a key regulator of striated muscle physiology and pathophysiology. Mutations in cysteine and glycine-rich protein 3 (CSRP3), the gene encoding MLP, are causative of human cardiomyopathies, whereas altered expression patterns are observed in human failing heart and skeletal myopathies. In vitro and in vivo evidences reveal a complex and diverse functional role of MLP in striated muscle, which is determined by its multiple interacting partners and subcellular distribution. Experimental evidence suggests that MLP is implicated in both myogenic differentiation and myocyte cytoarchitecture, although the full spectrum of its intracellular roles still unfolds.
Molecular Biology Division, Biomedical Research Foundation of the Academy of Athens, Greece.
Elizabeth
E
Vafiadaki
Molecular Biology Division, Biomedical Research Foundation of the Academy of Athens, Greece.
Demetrios A
DA
Arvanitis
Molecular Biology Division, Biomedical Research Foundation of the Academy of Athens, Greece; 4th Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Greece. Electronic address: dsanoudou@med.uoa.gr.
Despina
D
Sanoudou
D000818:Animals; D006331:Heart Diseases / Q000503:physiopathology; D006801:Humans; D060850:LIM-Homeodomain Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009124:Muscle Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009132:Muscles / Q000502:physiology*; D009135:Muscular Diseases / Q000503:physiopathology; D017434:Protein Structure, Tertiary
D060850:LIM-Homeodomain Proteins; D009124:Muscle Proteins
Cardiomyopathies; Differentiation; Heart failure; MLP; Muscle structure; Sarcomere; Skeletal myopathies