[Expression of TPX2 in hepatocellular carcinoma and its clinical significance].
OBJECTIVE
To explore the expression of TPX2 and its significance in hepatocellular carcinoma (HCC) tissue and examine the relationship between TPX2 and clinicopathological characteristics of HCC.


METHODS
Reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical staining were used to compare the expression of TPX2 in tumor and adjacent non-tumoral tissues.


RESULTS
The TPX2 mRNA expression was higher in tumor tissues than that in non-tumoral counterparts (30/50) (P < 0.05). The positive rate of TPX2 protein in tumor tissues was significantly higher than that in non-tumoral counterparts (56.0% vs 16.0%) (P < 0.05). The expression of TPX2 mRNA and protein were correlated with metastasis, recurrence and time of recurrence after curative resection (P < 0.05).


CONCLUSIONS
An over-expression of TPX2 may be risk factor of metastasis and recurrence after curative resection so that it is a potential biomarker for early diagnosis and prognosis of HCC.
Departments of Hepatobiliary Surgery & Clinical Laboratory Medicine,Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Bo
B
Liang
Yu
Y
Huang
Hua
H
He
Jialu
J
Li
Hui
H
Liao
Xincheng
X
Liu
Botang
B
Guo
Email: dhyang5810@yahoo.com.
Dinghua
D
Yang
D006528:Carcinoma, Hepatocellular; D018797:Cell Cycle Proteins; D006801:Humans; D008113:Liver Neoplasms; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; D011379:Prognosis; D012333:RNA, Messenger
D018797:Cell Cycle Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; D012333:RNA, Messenger; C122167:TPX2 protein, human