Percutaneous cryoablation for the treatment of recurrent thymoma: preliminary safety and efficacy.
Thymoma is the most common primary tumor of the anterior mediastinum and often recurs after initial surgical resection. In this case series, percutaneous cryoablation, a locally ablative technique, was used to treat 25 mediastinal and pleural recurrent thymoma lesions in five patients. Safety and short-term efficacy data were collected. In 23 percutaneous cryoablations (92%), there were no or minimal complications. One serious complication, myasthenia gravis flare, occurred. Over the duration of follow-up (median, 331 d), 18 of 20 ablated lesions (90%) showed no evidence of local recurrence. Percutaneous cryoablation shows promise as a safe and effective treatment modality for recurrent thymoma.
Department of Radiological Sciences University of California Los Angeles, Ronald Reagan Hospital, 757 Westwood Plaza, Room No. 1621, Los Angeles, CA 90095. Electronic address: fabtin@mednet.ucla.edu.
Fereidoun
F
Abtin
Division of Thoracic Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, California.
Robert D
RD
Suh
Department of Radiological Sciences University of California Los Angeles, Ronald Reagan Hospital, 757 Westwood Plaza, Room No. 1621, Los Angeles, CA 90095.
Leyla
L
Nasehi
Department of Radiological Sciences University of California Los Angeles, Ronald Reagan Hospital, 757 Westwood Plaza, Room No. 1621, Los Angeles, CA 90095.
Simon X
SX
Han
Department of Radiological Sciences University of California Los Angeles, Ronald Reagan Hospital, 757 Westwood Plaza, Room No. 1621, Los Angeles, CA 90095.
William
W
Hsu
Department of Radiological Sciences University of California Los Angeles, Ronald Reagan Hospital, 757 Westwood Plaza, Room No. 1621, Los Angeles, CA 90095.
Mathew
M
Quirk
Department of Radiological Sciences University of California Los Angeles, Ronald Reagan Hospital, 757 Westwood Plaza, Room No. 1621, Los Angeles, CA 90095.
Scott
S
Genshaft
Department of Radiological Sciences University of California Los Angeles, Ronald Reagan Hospital, 757 Westwood Plaza, Room No. 1621, Los Angeles, CA 90095.
Antony J
AJ
Gutierrez
Department of Radiological Sciences University of California Los Angeles, Ronald Reagan Hospital, 757 Westwood Plaza, Room No. 1621, Los Angeles, CA 90095.
Robert B
RB
Cameron
D000328:Adult; D000368:Aged; D003452:Cryosurgery / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D013945:Thymoma / Q000601:surgery*; D013953:Thymus Neoplasms / Q000601:surgery*; D016896:Treatment Outcome
CTCAE; Common Terminology Criteria for Adverse Events (CTCAE)