[Hereditary angiœdema treatments: Recommendations from the French national center for angiœdema (Bordeaux consensus 2014)].
BACKGROUND
Treatment of hereditary angiœdema (HAE), associated or not with C1Inh deficiency, has dramatically changed these last five years. Four new therapeutic options are now available in France. The French Reference Centre for Angioedema has a consensus meeting to give recommendations about their use.


METHODS
The proposals were based on a CREAK survey and a comprehensive review of the literature done by 4 experts. These proposals were submitted to a vote at a national CREAK meeting (Bordeaux, March 2014). Fifty-one participants, 15 experts and one expert-patient have participated. The consensus concerned HAE patients with or without C1Inh deficiency. Were excluded children, patients with acquired AE and with drug induced AE.


RESULTS
Proposals were done for 4 cases: acute attack treatment, short-term prophylaxis, long-term prophylaxis and pregnant women. The drugs cited were: C1Inh concentrate, icatibant, tranexamic acid, danazol and chlormadinone acetate.


CONCLUSIONS
Consensual proposals were obtained during this meeting. They will be now widely diffused.
CHU de Grenoble, centre national de référence des angiœdèmes, 38043 Grenoble cedex 09, France; CHU de Grenoble, clinique universitaire de médecine interne, centre de référence des angiœdèmes, 38043 Grenoble cedex 09, France; Université Grenoble-Alpes, unité Inserm 1036, CEA-Grenoble, 38054 Grenoble cedex 09, France. Electronic address: lbouillet@chu-grenoble.fr.
Laurence
L
Bouillet
CHU de Grenoble, centre national de référence des angiœdèmes, 38043 Grenoble cedex 09, France; CHU de Grenoble, pôle pharmacie, ThEMAS TIMC-IMAG (UMR CNRS 5525), 38700 La Tronche, France.
Audrey
A
Lehmann
CHU de Grenoble, centre national de référence des angiœdèmes, 38043 Grenoble cedex 09, France; Université Paris Descartes, AP-HP, hôpital Port Royal-Cochin, département de gynécologie, 75015 Paris, France.
Anne
A
Gompel
CHU de Grenoble, centre national de référence des angiœdèmes, 38043 Grenoble cedex 09, France; CHU de Grenoble, clinique universitaire de médecine interne, centre de référence des angiœdèmes, 38043 Grenoble cedex 09, France.
Isabelle
I
Boccon-Gibod
CHU de Grenoble, centre national de référence des angiœdèmes, 38043 Grenoble cedex 09, France; Université Lille Nord, CHRU de Lille, hôpital Claude-Huriez, service de médecine interne, 59000 Lille, France.
David
D
Launay
CHU de Grenoble, centre national de référence des angiœdèmes, 38043 Grenoble cedex 09, France; Université Paris 6, AP-HP, hôpital Saint-Antoine, service de médecine interne, 75012 Paris, France.
Olivier
O
Fain
D054179:Angioedemas, Hereditary / Q000175:diagnosis / Q000628:therapy*; D001942:Breast Feeding; D005260:Female; D005602:France; D006801:Humans; D007743:Labor, Obstetric; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000628:therapy; D012720:Severity of Illness Index