Functional connectivity arises from a slow rhythmic mechanism.
The mechanism underlying temporal correlations among blood oxygen level-dependent signals is unclear. We used oxygen polarography to better characterize oxygen fluctuations and their correlation and to gain insight into the driving mechanism. The power spectrum of local oxygen fluctuations is inversely proportional to frequency raised to a power (1/f) raised to the beta, with an additional positive band-limited component centered at 0.06 Hz. In contrast, the power of the correlated oxygen signal is band limited from ∼ 0.01 Hz to 0.4 Hz with a peak at 0.06 Hz. These results suggest that there is a band-limited mechanism (or mechanisms) driving interregional oxygen correlation that is distinct from the mechanism(s) driving local (1/f) oxygen fluctuations. Candidates for driving interregional oxygen correlation include rhythmic or pseudo-oscillatory mechanisms.
Departments of Anatomy and Neurobiology, jing@eye-hand.wustl.edu.
Jingfeng M
http://orcid.org/0000-0001-6519-3462
JM
Li
Departments of Anatomy and Neurobiology.
William J
WJ
Bentley
Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Abraham Z
AZ
Snyder
Departments of Anatomy and Neurobiology, Radiology, and Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Marcus E
ME
Raichle
Departments of Anatomy and Neurobiology.
Lawrence H
LH
Snyder
D000465:Algorithms; D000818:Animals; D001145:Arrhythmias, Cardiac; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D004566:Electrodes; D006339:Heart Rate; D007858:Learning; D008251:Macaca; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009434:Neural Pathways; D016011:Normal Distribution; D009991:Oscillometry; D010100:Oxygen / Q000737:chemistry; D011048:Polarography; D012146:Rest; D012815:Signal Processing, Computer-Assisted
D010100:Oxygen
band-limited; criticality; oscillation; oxygen polarography; resting-state functional connectivity