Effects of extremely low-frequency electromagnetic fields (ELF-EMF) exposure on B6C3F1 mice.
OBJECTIVE
Long-term exposure study was conducted to investigate the effects of extremely low-frequency electromagnetic field on the tumor promotion process and fertility.


METHODS
Ten pregnant C57BL/6NCrj mice were exposed to 50 Hz field 500 mG for 1 week (12 h per day), and 24 male and 42 female B6C3F1mice born from them were further exposed up to 15.5 months. As a control group, 10 pregnant mice were bred without exposure, and 30 produced male and 32 female mice were observed without exposure for the same period.


RESULTS
Mean body weights of exposed groups of male and female mice were decreased significantly than those of the control groups. In exposed mice, there was no increased incidence of liver and lung tumor. In female mice, the incidence of chronic myeloid leukemia [3/42 (7%)] in the exposed group was significantly greater than in the control group. The size of seminiferous tubules in the EMF exposed groups were significantly less than the control group.


CONCLUSIONS
These data support the hypothesis that long-term exposure of 50 Hz magnetic fields is a significant risk factor for neoplastic development and fertility in mice.
Department of Physiopathology and Gastrointestinal Surgery, Guilin Medical University, Guilin, 541004, Guangxi, China.
Guangying
G
Qi
Xiaoxu
X
Zuo
Lihua
L
Zhou
Eriko
E
Aoki
Aya
A
Okamula
Mika
M
Watanebe
Haipeng
H
Wang
Qiuhui
Q
Wu
Huiling
H
Lu
Handan
H
Tuncel
Hiromitsu
H
Watanabe
Sien
S
Zeng
Fumio
F
Shimamoto
D000818:Animals; D063646:Carcinogenesis / Q000528:radiation effects*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005260:Female; D005298:Fertility / Q000528:radiation effects*; D015994:Incidence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000453:epidemiology / Q000209:etiology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D012671:Seminiferous Tubules / Q000528:radiation effects