Diabetic muscle infarction: a systematic review.
BACKGROUND
Diabetic muscle infarction (DMI) is a rare complication associated with poorly controlled diabetes mellitus. Less than 200 cases have been reported in the literature since it was first described over 45 years ago. There is no clear 'standard of care' for managing these patients.


METHODS
PubMed searches were conducted for 'diabetic muscle infarction' and 'diabetic myonecrosis' from database inception through July 2014. All articles identified by these searches were reviewed in detail if the article text was available in English.


RESULTS
The current literature exists as case reports or small case series, with no prospective or higher-order treatment studies available. Thus, an evidence-based approach to data synthesis was difficult. The available literature is presented objectively with an attempt to describe clinically relevant trends and findings in the diagnosis and management of DMI.


CONCLUSIONS
Early recognition of DMI is key, so appropriate treatment can be initiated. MRI is the radiological study of choice. A combination of bed rest, glycemic control, and non-steroidal anti-inflammatory drug therapy appears to yield the shortest time to symptom resolution and the lowest risk of recurrence.
Department of Medicine , University of Mississippi Medical Center , Jackson, Mississippi , USA.
William B
WB
Horton
Department of Medicine , University of Mississippi Medical Center , Jackson, Mississippi , USA.
Jeremy S
JS
Taylor
Department of Radiology , University of Mississippi Medical Center , Jackson, Mississippi , USA.
Timothy J
TJ
Ragland
Department of Medicine , University of Mississippi Medical Center , Jackson, Mississippi , USA ; Division of Endocrinology , University of Mississippi Medical Center , Jackson, Mississippi , USA.
Angela R
0000-0002-0848-2310
AR
Subauste
Clinical Complications; NSAIDs