Positron emission tomography evaluation of sinonasal inverted papilloma and related conditions: a prospective clinical study.
OBJECTIVE
This study aims to determine whether there is a difference between inverted papilloma (IP) and nasal polyp, and squamous cell carcinoma (SCC) with regard to fluorodeoxyglucose uptake.


METHODS
Between September 2007 and May 2014, positron emission tomography computed tomography (PET/CT) images of 27 patients (20 males, 7 females; mean age 53.4 years; range 18 to 74 years), with unilateral polyposis diagnosed on examination and tomographic scans of paranasal sinus were obtained. Nasal polyps in eight of the patients (group 1), IP in 10 patients (group 2), and SCC in nine patients (group 3) were found. The data were compared with Kruskal-Wallis and Mann-Whitney U tests.


RESULTS
The mean maximum standardized uptake (SUVmax) values were found to be 2.9 in the group 1; 7.8 in the group 2, and 17.8 in the group 3. There was significant difference in the SUVmax values between the group 1 and the group 2 (p=0.016), the group 1 and the group 3 (p=0.001), and the group 2 and the group 3 (p=0.01).


CONCLUSIONS
According to the results of this study, PET/CT scan in the patients with unilateral polyposis is invaluable to distinguish nasal polyp from IP and SCC. It is also useful to recognize the distinctions between IP and SCC. In our study of 27 patients, a SUVmax of 6 or higher ruled out the presence of nasal polyp [95% CI (5.93 to 13.39), specificity 100%] might also be clinically useful.
Department of Otolaryngology, Medical Faculty of Başkent University, Adana Seyhan Hospital, 01110 Seyhan, Adana, Turkey. iy38@yahoo.com.
İsmail
İ
Yılmaz
Mehmet
M
Reyhan
Tuba
T
Canpolat
Cüneyt
C
Yılmazer
Alper Nabi
AN
Erkan
Mehmet
M
Yaşar
Volkan
V
Akdoğan
Levent N N
LN
Özlüoğlu
D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods* / Q000706:statistics & numerical data; D009298:Nasal Polyps / Q000000981:diagnostic imaging; D009669:Nose Neoplasms / Q000000981:diagnostic imaging*; D018308:Papilloma, Inverted / Q000000981:diagnostic imaging*; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods* / Q000706:statistics & numerical data; D011446:Prospective Studies; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000706:statistics & numerical data; D055815:Young Adult
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18