MeDiA: Mean Distance Association and Its Applications in Nonlinear Gene Set Analysis.
Probabilistic association discovery aims at identifying the association between random vectors, regardless of number of variables involved or linear/nonlinear functional forms. Recently, applications in high-dimensional data have generated rising interest in probabilistic association discovery. We developed a framework based on functions on the observation graph, named MeDiA (Mean Distance Association). We generalize its property to a group of functions on the observation graph. The group of functions encapsulates major existing methods in association discovery, e.g. mutual information and Brownian Covariance, and can be expanded to more complicated forms. We conducted numerical comparison of the statistical power of related methods under multiple scenarios. We further demonstrated the application of MeDiA as a method of gene set analysis that captures a broader range of responses than traditional gene set analysis methods.
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America.
Hesen
H
Peng
Department of Hematology, Yantai Yuhuangding Hospital, Yantai, Shandong, China.
Junjie
J
Ma
Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine, Suwanee, Georgia, United States of America.
Yun
Y
Bai
School of Software Engineering, Tongji University, Shanghai, China; Advanced Institute of Translational Medicine, Tongji University, Shanghai, China.
Jianwei
J
Lu
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America.
Tianwei
T
Yu
D000465:Algorithms; D002446:Celiac Disease / Q000235:genetics / Q000378:metabolism; D019295:Computational Biology / Q000379:methods*; D020869:Gene Expression Profiling / Q000379:methods*; D053263:Gene Regulatory Networks; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism; D015233:Models, Statistical; D015398:Signal Transduction