Another face of RIPK1.
Receptor‐interacting protein kinase‐1 (RIPK1) sits at a signaling node controlling a number of functional pathways. These include both positive and negative control of apoptosis and necroptosis (a form of regulated necrosis). In this issue of EMBO Reports, Yonekawa and colleagues describe another function for RIPK1, the inhibition of autophagy via ERK‐mediated phosphorylation of the transcription factor, TFEB [1]. Their findings are considered in the context of RIPK1 signaling, and how it is engaged.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Douglas R
DR
Green
D000818:Animals; D017209:Apoptosis; D001343:Autophagy; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000378:metabolism*
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D053422:Receptor-Interacting Protein Serine-Threonine Kinases