Immune response in pigs treated with therapeutic doses of enrofloxacin at the time of vaccination against Aujeszky's disease.
The effect of treatment with enrofloxacin was studied on the postvaccinal immune response in pigs. Forty pigs were used (control not vaccinated (C), control vaccinated (CV), vaccinated, received enrofloxacin (ENRO)). From day -1 to day 3 pigs from ENRO group received enrofloxacin at the recommended dose. Pigs from ENRO and CV groups were vaccinated twice against Aujeszky's disease virus (ADV). There was a significant delay in the production of humoral response of enrofloxacin dosed pigs when compared with CV group. Moreover, in ENRO group the significant decrease in IFN-γ production and significantly lower values of stimulation index after ADV restimulation was noted, as compared with CV group. The secretion of IL-6, IL-10 and TNF-α by PBMC after recall stimulation was also affected in ENRO group. The results indicate that enrofloxacin, in addition to its antimicrobial properties, possess significant immunomodulatory effects and may alter the immune response to vaccines.
Department of Swine Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland. Electronic address: mpomorska@piwet.pulawy.pl.
Małgorzata
M
Pomorska-Mól
Department of Swine Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland.
Ewelina
E
Czyżewska-Dors
Department of Swine Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland.
Krzysztof
K
Kwit
Department of Radiobiology, National Veterinary Research Institute, 24-100 Pulawy, Poland.
Jarosław
J
Rachubik
Department of Swine Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland.
Andrzej
A
Lipowski
Department of Swine Diseases, National Veterinary Research Institute, 24-100 Pulawy, Poland.
Zygmunt
Z
Pejsak
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000494:pharmacology*; D011558:Herpesvirus 1, Suid / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D056747:Immunomodulation / Q000187:drug effects*; D011557:Pseudorabies / Q000276:immunology* / Q000628:therapy / Q000821:virology; D013552:Swine; D013553:Swine Diseases / Q000276:immunology* / Q000628:therapy / Q000821:virology; D014765:Viral Vaccines / Q000276:immunology*
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D014765:Viral Vaccines; D000077422:Enrofloxacin
Enrofloxacin; Immune response; Pigs; Vaccination