Quantitative analysis coupled with toxic evaluation to investigate the influence of sulfur-fumigation on the quality of Chrysanthemum morifolium.
In the present study, quantitative analysis coupled with toxic evaluation was applied to investigate the influence of sulfur-fumigation on the quality of Chrysanthemum morifolium. The results showed that the average contents of six flavonoids (cynaroside, hyperoside, isoquercitrin, luteolin, apigenin, and diosmetin) in sulfur-fumigated C. morifolium samples decreased by about 6.2%, 3.5%, 22.0%, 33.3%, 26.0%, and 36.9%, respectively, while the average contents of two organic acids (chlorogenic acid and isochlorogenic acid A) in sulfur-fumigated C. morifolium samples increased by about 16.8% and 7.6%, respectively. Furthermore, high dosage sulfur-fumigated C. morifolium could induce hydropic degeneration in epithelial cells of the renal tubule and interstitial edema. This indicates that sulfur-fumigated C. morifolium may lead to renal toxicity.
Ke
K
Ding
Gang
G
Cao
Zhiwei
Z
Xu
Xiaocheng
X
Chen
D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D031202:Chrysanthemum / Q000737:chemistry* / Q000633:toxicity; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000633:toxicity; D005260:Female; D005651:Fumigation; D008297:Male; D011786:Quality Control; D051381:Rats; D017207:Rats, Sprague-Dawley; D013455:Sulfur / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D013455:Sulfur