Cytotoxic active constituents of essential oils of Curcuma longa and Curcuma zanthorrhiza.
The polar and apolar fractions of Curcuma longa and C. zanthorriza enriched by ar-turmerone, ar-curcumene and xanthorrizol were screened for cytotoxic activity against the HeLa cell line. Actinomycin D and curcumin were used as reference samples, both known for their cytotoxic properties. Amongst all fractions tested, the xanthorrizol fraction (CC50: 26.1 ± 1.9 μM) showed the strongest cytotoxic properties similar to those of curcumin (CC50: 8.1 ± 1.7 μM). Further studies also revealed that the cytotoxic effects of the extracts and pure compounds are caused by apoptosis induction identified by the cleaved form of PARP protein.
Erich
E
Schmidt
Boris
B
Ryabchenko
Juergen
J
Wanner
Walter
W
Jäger
Leopold
L
Jirovetz
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D030024:Curcuma / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D009822:Oils, Volatile / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile