The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA.
New water-soluble p-tert-butylthiacalix[4]arenes containing peptide and quaternary ammonium fragments in cone and 1,3-alternate conformations were synthesized and characterized. The interaction of the macrocycles with DNA was studied by UV-spectroscopy, DLS and TEM. It was shown that the interaction of the self-associates based on p-tert-butylthiacalix[4]arenes tetrasubstituted at the lower rim with glycine and quaternary ammonium fragments in cone and 1,3-alternate conformations with DNA led to the formation of particles of about 99-192 nm in size.
Kazan (Volga Region) Federal University, A.M. Butlerov Chemical Institute, 420008 Kremlevskaya, 18, Kazan, Russian Federation. Ivan.Stoikov@mail.ru.
Pavel L
PL
Padnya
Elena A
EA
Andreyko
Olga A
OA
Mostovaya
Ildar Kh
IKh
Rizvanov
Ivan I
II
Stoikov
D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D008968:Molecular Conformation; D010316:Particle Size; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
D010446:Peptide Fragments; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; C442852:p-tert-butylthiacalix(4)arene; D004247:DNA