Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing.
OBJECTIVE
To investigate the effects of topical application of a Gold Silk Sericin (GSS) complex on biophysical parameters related to skin ageing.


METHODS
A range of non-invasive bioengineering methods were deployed in an 8-week randomized, double-blinded, vehicle-controlled, split-face study among 40 female subjects aged 40-70. Endpoints measured included expert grades of skin condition, stratum corneum (SC) hydration, SC barrier function, elasticity and surface topography.


RESULTS
The GSS complex produced significant single-variable (P < 0.05) improvements in SC hydration, barrier function, elasticity and surface topography compared with the Vehicle control.


CONCLUSIONS
The GSS complex examined in this study represents an interesting new cosmetic topical technology with which to address multiple aspects of aged/photoaged female facial skin.
San Gallicano Dermatological Institute, Via Chianesi 53, 00144, Rome, Italy.
E
E
Berardesca
San Gallicano Dermatological Institute, Via Chianesi 53, 00144, Rome, Italy.
M
M
Ardigo
Department of Clinical Dermatology, San Gallicano Institute, Rome, Italy.
N
N
Cameli
San Gallicano Dermatological Institute, Via Chianesi 53, 00144, Rome, Italy.
M
M
Mariano
San Gallicano Dermatological Institute, Via Chianesi 53, 00144, Rome, Italy.
M
M
Agozzino
Procter & Gamble, London Innovation Centre, Egham, Surrey, TW20 9NW, U.K.
P J
PJ
Matts
D000287:Administration, Topical; D004311:Double-Blind Method; D006801:Humans; D009536:Niacinamide / Q000008:administration & dosage*; D014677:Pharmaceutical Vehicles; D047030:Sericins / Q000008:administration & dosage*; D015595:Skin Aging / Q000187:drug effects*
D014677:Pharmaceutical Vehicles; D047030:Sericins; D009536:Niacinamide
hair + body care; moisturisation; skin repair/acne/rosacea/dandruff/striae