Electrospinning polyvinylidene fluoride fibrous membranes containing anti-bacterial drugs used as wound dressing.
The aim of this study was to synthesis drug-loaded fibrous membrane scaffolds for potential applications as wound dressing. Polyvinylidene fluoride (PVDF) fibrous membranes were loaded with enrofloxacin (Enro) drugs by using an electrospinning process, and their mechanical strength, drug release profile and anti-bacterial properties were evaluated. Enro drug-loaded PVDF membranes exhibited good elasticity, flexibility and excellent mechanical strength. The electrospinning Enro/PVDF membranes showed a burst drug release in the initial 12h, followed by sustained release for the next 3 days, which was an essential property for antibiotic drugs applied for wound healing. The drug-loaded PVDF fibrous membranes displayed excellent anti-bacterial activity toward Escherichia coli and Staphylococcus aureus. The results suggest that electrospinning PVDF membrane scaffolds loaded with drugs can be used as wound dressing.
Institute of Biomaterial, Department of Applied Chemistry, College of Science, South China Agricultural University, Guangzhou 510642, China.
Ting
T
He
Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Jingnan
J
Wang
Institute of Biomaterial, Department of Applied Chemistry, College of Science, South China Agricultural University, Guangzhou 510642, China.
Peilin
P
Huang
Department of Anatomy, Guangdong Provincial Key laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, China.
Baozhen
B
Zeng
Institute of Biomaterial, Department of Applied Chemistry, College of Science, South China Agricultural University, Guangzhou 510642, China.
Haihong
H
Li
College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Qingyun
Q
Cao
Key Laboratory of Application Technology of Environmental Photocatalysis of Hunan Province, Changsha University, Changsha 410022, China.
Shiying
S
Zhang
Key Laboratory of Application Technology of Environmental Photocatalysis of Hunan Province, Changsha University, Changsha 410022, China.
Zhuo
Z
Luo
Research Center of Translational Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: dengyub@mail.sysu.edu.cn.
David Y B
DY
Deng
Department of Anatomy, Guangdong Provincial Key laboratory of Construction and Detection in Tissue Engineering, Southern Medical University, Guangzhou 510515, China. Electronic address: zhanghwu@mail2.sysu.edu.cn.
Hongwu
H
Zhang
Institute of Biomaterial, Department of Applied Chemistry, College of Science, South China Agricultural University, Guangzhou 510642, China. Electronic address: zhouwuyi@scau.edu.cn.
Wuyi
W
Zhou
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D001458:Bandages; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004548:Elasticity; D055664:Electrochemical Techniques / Q000379:methods; D000077422:Enrofloxacin; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D024841:Fluoroquinolones / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D011145:Polyvinyls / Q000737:chemistry*; D017207:Rats, Sprague-Dawley; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014945:Wound Healing / Q000187:drug effects*; D014961:X-Ray Diffraction; D005465:Fluorocarbon Polymers
D000900:Anti-Bacterial Agents; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D008567:Membranes, Artificial; D011145:Polyvinyls; C024865:polyvinylidene fluoride; D005465:Fluorocarbon Polymers
Drug release; Electrospinning; Enro/PVDF fibrous membranes; Wound dressing