Novel treatment strategies for feline chronic kidney disease: A critical look at the potential of mesenchymal stem cell therapy.
Stem cell therapy is an innovative field of scientific investigation with tremendous potential for clinical application that holds promise for the treatment of a variety of diseases in veterinary medicine. Based on the known desirable properties of mesenchymal stem cells, the therapy has potential for treatment of both acute kidney injury and chronic kidney disease in cats. This review details terminology commonly used in this field of study, sources of mesenchymal stem cells and their proposed mechanism of action particularly as it relates to renal repair. Studies performed in rodent models of chronic kidney disease and feline clinical trial results are also summarized with the aim of providing an overview of the current status of this treatment modality and its potential for the future.
Center for Immune and Regenerative Medicine, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA. Electronic address: jquimby@colostate.edu.
J M
JM
Quimby
Center for Immune and Regenerative Medicine, Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
S W
SW
Dow
D000818:Animals; D002371:Cat Diseases / Q000628:therapy*; D002415:Cats; D045164:Mesenchymal Stem Cell Transplantation / Q000662:veterinary*; D051436:Renal Insufficiency, Chronic / Q000628:therapy / Q000662:veterinary*
Cat; Mesenchymal stromal cell; Nephrology; Regenerative medicine; Renal