The cell secretome, a mediator of cell-to-cell communication.
We are witnessing the emergence of a novel type of biological regulation, namely, the communication between cells via their secreted substances, the secretome. This brief overview is based on the available published data and our own experience. We discuss three vignettes illustrating the importance of communication via the secretome: (1) the secretome of stem cells and its effects in sepsis and systemic inflammatory response; (2) the profibrotic secretomes partially responsible for development of fibrotic complications; and (3) the contribution of senescence-associated secretory products to the propagation of the senescence phenotype. Considering the richness of secretomes of different cells under diverse conditions, it becomes imperative to gain insights into their individual components in an attempt to harness cell secretomes for therapeutic purposes.
Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA.
Joseph
J
Zullo
Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA.
Kei
K
Matsumoto
Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA.
Sandhya
S
Xavier
Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA.
Brian
B
Ratliff
Departments of Medicine, Pharmacology and Physiology, Renal Research Institute, New York Medical College, Valhalla, NY 10595, USA. Electronic address: Michael_goligorsky@nymc.edu.
Michael S
MS
Goligorsky
D000818:Animals; D002450:Cell Communication; D002477:Cells / Q000166:cytology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007511:Ischemia / Q000473:pathology; D008264:Macrophages / Q000166:cytology; D059630:Mesenchymal Stem Cells / Q000166:cytology; D018805:Sepsis / Q000473:pathology
Fibrosis; Proteome; Senescence; Sepsis