Amorfrutins Are Natural PPARγ Agonists with Potent Anti-inflammatory Properties.
Amorfrutins are isoprenoid-substituted benzoic acid derivatives, which were found in Amorpha fruticosa L. (bastard indigo) and in Glycyrrhiza foetida Desf. (licorice). Recently, amorfrutins were shown to be selective activators of the nuclear receptor PPARγ. Here, we investigated the effects and PPARγ-based mechanisms of reducing inflammation in colon cells by treatment with amorfrutins. In TNF-α-stimulated colon cells amorfrutin A (1) reduced significantly the expression and secretion of several inflammation mediators, in part due to interaction with PPARγ. These results support the hypothesis that amorfrutins may have the potential to treat inflammation disorders such as chronic inflammatory bowel diseases.
†Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany.
Luise
L
Fuhr
†Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany.
Morten
M
Rousseau
†Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany.
Annabell
A
Plauth
‡Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
Frank C
FC
Schroeder
†Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany.
Sascha
S
Sauer
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D006035:Glycyrrhiza / Q000378:metabolism; D015394:Molecular Structure; D047495:PPAR gamma / Q000819:agonists*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D012459:Salicylates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D047495:PPAR gamma; D018160:Receptors, Cytoplasmic and Nuclear; D012459:Salicylates; D013267:Stilbenes; D014409:Tumor Necrosis Factor-alpha; C000597294:amorfrutin A; C582540:amorfrutin B