Posterior predictive checking of multiple imputation models.
Multiple imputation is gaining popularity as a strategy for handling missing data, but there is a scarcity of tools for checking imputation models, a critical step in model fitting. Posterior predictive checking (PPC) has been recommended as an imputation diagnostic. PPC involves simulating "replicated" data from the posterior predictive distribution of the model under scrutiny. Model fit is assessed by examining whether the analysis from the observed data appears typical of results obtained from the replicates produced by the model. A proposed diagnostic measure is the posterior predictive "p-value", an extreme value of which (i.e., a value close to 0 or 1) suggests a misfit between the model and the data. The aim of this study was to evaluate the performance of the posterior predictive p-value as an imputation diagnostic. Using simulation methods, we deliberately misspecified imputation models to determine whether posterior predictive p-values were effective in identifying these problems. When estimating the regression parameter of interest, we found that more extreme p-values were associated with poorer imputation model performance, although the results highlighted that traditional thresholds for classical p-values do not apply in this context. A shortcoming of the PPC method was its reduced ability to detect misspecified models with increasing amounts of missing data. Despite the limitations of posterior predictive p-values, they appear to have a valuable place in the imputer's toolkit. In addition to automated checking using p-values, we recommend imputers perform graphical checks and examine other summaries of the test quantity distribution.
Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, The Royal Children's Hospital, Flemington Road Parkville, Victoria, 3052, Australia.|Department of Paediatrics (RCH Academic Centre), Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, The Royal Children's Hospital, Flemington Road Parkville, Victoria, 3052, Australia.
Cattram D
CD
Nguyen
Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, The Royal Children's Hospital, Flemington Road Parkville, Victoria, 3052, Australia.|Department of Paediatrics (RCH Academic Centre), Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, The Royal Children's Hospital, Flemington Road Parkville, Victoria, 3052, Australia.
Katherine J
KJ
Lee
Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute, The Royal Children's Hospital, Flemington Road Parkville, Victoria, 3052, Australia.|Department of Paediatrics (RCH Academic Centre), Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, The Royal Children's Hospital, Flemington Road Parkville, Victoria, 3052, Australia.
John B
JB
Carlin
D000465:Algorithms; D001699:Biometry / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D005260:Female; D048788:Growth and Development; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D015233:Models, Statistical; D010290:Parents / Q000523:psychology
Missing data; Model checking; Multiple imputation; Posterior predictive checking; Simulations