[Study on antimicrobial effect of the mixture of Chinese medicine-chitosan to Candida albicans and the possibility as denture adhesive].
OBJECTIVE
To observe the antimicrobial effect and the tensile bond strength of water-soluble chitosan after adding different Chinese medicines to Candida albicans.


METHODS
The extract of 6 kinds of Chinese medicine by decoction in different concentrations were mixed with chitosan, and the most effective mixture inhibiting Candida albicans and the minimal inhibitory concentration (MIC) were explored; Then the tensile bond strength of the mixture was tested and compared with Protefix denture adhesive. The data was analyzed with SPSS17.0 software package.


RESULTS
The antibacterial effect of polyphylla-chitosan mixture was the best among the 6 kinds of Chinese medicine- chitosan mixture, and its MIC was 1.563 mg/mL. The tensile bond strength of polyphylla-chitosan mixture at 0 h and 12 h when immersed in artificial saliva were significantly larger than Protefix denture adhesive. The average value and the maximum value was significantly greater than the Protefix denture adhesive (P<0.05).


CONCLUSIONS
Polyphylla-chitosan mixture has good antibacterial effect on Candida albicans and large tensile bond strength.
Department of Prosthodontics, School of Stomatology, Hebei United University. Tangshan 063000, Hebei Province, China.E-mail:873569152@qq.com.
Lv
L
Li
He
H
Meng
Jin-yuan
JY
Li
Wen-hui
WH
Wu
Rui-ying
RY
Liang
D000269:Adhesives; D000818:Animals; D000890:Anti-Infective Agents; D002176:Candida albicans; D048271:Chitosan; D001517:Coleoptera; D001840:Dental Bonding; D003738:Dental Cements; D008422:Materials Testing; D008516:Medicine, Chinese Traditional; D013718:Tensile Strength
D000269:Adhesives; D000890:Anti-Infective Agents; D003738:Dental Cements; D048271:Chitosan