Polymer encapsulation of magnesium to control biodegradability and biocompatibility.
Clinical utility of biodegradable magnesium implants is undermined by the untimely degradation of these materials in vivo. Their high corrosion rate leads to loss of mechanical integrity, peri-implant alkalization and localised accumulation of hydrogen gas. Biodegradable coatings were produced on pure magnesium using RF plasma polymerisation. A monoterpene alcohol with known anti-inflammatory and antibacterial properties was used as a polymer precursor. The addition of the polymeric layer was found to reduce the degradation rate of magnesium in simulated body fluid. The in vitro studies indicated good cytocompatibility of non-adherent THP-1 cells and mouse macrophage cells with the polymer, and the polymer coated sample. The viability of THP-1 cells was significantly improved when in contact with polymer encapsulated magnesium compared to unmodified samples. Collectively, these results suggest plasma enhanced polymer encapsulation of magnesium as a suitable method to control degradation kinetics of this biomaterial.
Kateryna
K
Bazaka
Natkunam
N
Ketheesan
Mohan V
MV
Jacob
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D008274:Magnesium / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D031650:Melaleuca / Q000737:chemistry; D051379:Mice; D039821:Monoterpenes / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D020099:Coated Materials, Biocompatible; D039821:Monoterpenes; D011108:Polymers; D008274:Magnesium