5-HTTLPR differentially predicts brain network responses to emotional faces.
The effects of the 5-HTTLPR polymorphism on neural responses to emotionally salient faces have been studied extensively, focusing on amygdala reactivity and amygdala-prefrontal interactions. Despite compelling evidence that emotional face paradigms engage a distributed network of brain regions involved in emotion, cognitive and visual processing, less is known about 5-HTTLPR effects on broader network responses. To address this, we evaluated 5-HTTLPR differences in the whole-brain response to an emotional faces paradigm including neutral, angry and fearful faces using functional magnetic resonance imaging in 76 healthy adults. We observed robust increased response to emotional faces in the amygdala, hippocampus, caudate, fusiform gyrus, superior temporal sulcus and lateral prefrontal and occipito-parietal cortices. We observed dissociation between 5-HTTLPR groups such that LA LA individuals had increased response to only angry faces, relative to neutral ones, but S' carriers had increased activity for both angry and fearful faces relative to neutral. Additionally, the response to angry faces was significantly greater in LA LA individuals compared to S' carriers and the response to fearful faces was significantly greater in S' carriers compared to LA LA individuals. These findings provide novel evidence for emotion-specific 5-HTTLPR effects on the response of a distributed set of brain regions including areas responsive to emotionally salient stimuli and critical components of the face-processing network. These findings provide additional insight into neurobiological mechanisms through which 5-HTTLPR genotype may affect personality and related risk for neuropsychiatric illness.
Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark.|Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark.
Patrick M
PM
Fisher
Rotman Research Institute at Baycrest, University of Toronto, Toronto, Canada.|Department of Psychology and Psychiatry, University of Toronto, Toronto, Canada.
Cheryl L
CL
Grady
Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark.|Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark.
Martin K
MK
Madsen
Rotman Research Institute at Baycrest, University of Toronto, Toronto, Canada.|Department of Medical Physics, University of Toronto, Toronto, Canada.
Stephen C
SC
Strother
Center for Integrated Molecular Brain Imaging, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark.|Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen O, Denmark.
Gitte M
GM
Knudsen
D000328:Adult; D000786:Anger / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D005149:Facial Expression; D005239:Fear / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins
5-HTTLPR; emotion; faces; partial least squares; serotonin