[The significance of monitoring procalcitonin when applying antibiotics to trichlorethylene dermatitis].
OBJECTIVE
To investigate the significance of monitoring procalcitonin (PCT) when applying antibiotics to trichlorethylene (TCE)-induced dermatitis.


METHODS
One hundred and two patients who were hospitalized and recovered from TCE-induced dermatitis in our hospital from 2006 to 2013 were enrolled as subjects. Based on whether the PCT level was monitored or not, we divided patients into regular group and PCT group. For the regular group, we applied antibiotic treatment and determined the course of treatment based on clinical symptoms, laboratory test results, medical imaging results, and bacterial culture. For the PCT group, in addition to the above treatments, antibiotic treatment was applied when the PCT level was not lower than 0.25 ng/ml and stopped when the PCT level was lower than 0.25 ng/ml. The distribution of bacterial infection sites, type of bacteria, type of antibiotics, average period of hospitalization, and course of antibiotic treatment were compared between the two groups.


RESULTS
There were no significant differences in the distribution of bacterial infection sites, type of bacteria, type of antibiotics, and average period of hospitalization between the two groups (P > 0.05). The course of antibiotic treatment for the PCT group was significantly shorter than that for the regular group (25.37 ± 11.66 vs 20.58 ± 7.53 d, P < 0.05).


CONCLUSIONS
Under similar conditions of bacterial infection, antibiotic treatment of TCE-induced dermatitis based on the serum PCT level can significantly shorten the course of treatment and avoid the abuse of antibiotics.
Shen Zhen Prevention and Treatment Center for Occupational Diseasa.Guang Dong Shen Zhen 518001, China.
Jie
J
Situ
Shen Zhen Prevention and Treatment Center for Occupational Diseasa.Guang Dong Shen Zhen 518001, China.
Xueqin
X
Yang
Shen Zhen Prevention and Treatment Center for Occupational Diseasa.Guang Dong Shen Zhen 518001, China.
Chunmei
C
Lin
Shen Zhen Prevention and Treatment Center for Occupational Diseasa.Guang Dong Shen Zhen 518001, China.
Shiliang
S
Wei
Shen Zhen Prevention and Treatment Center for Occupational Diseasa.Guang Dong Shen Zhen 518001, China.
Liu
L
Shi
Shen Zhen Prevention and Treatment Center for Occupational Diseasa.Guang Dong Shen Zhen 518001, China.
Ningyu
N
Zhang
Shen Zhen Prevention and Treatment Center for Occupational Diseasa.Guang Dong Shen Zhen 518001, China.
Lingli
L
Luo
Shen Zhen Prevention and Treatment Center for Occupational Diseasa.Guang Dong Shen Zhen 518001, China. E-mail: zhangjjianjie1@126.com.
Jianjie
J
Zhang
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria; D001424:Bacterial Infections; D002116:Calcitonin / Q000032:analysis*; D015740:Calcitonin Gene-Related Peptide; D003875:Drug Eruptions / Q000188:drug therapy*; D006760:Hospitalization; D006801:Humans; D008991:Monitoring, Physiologic; D011498:Protein Precursors / Q000032:analysis*; D014241:Trichloroethylene / Q000633:toxicity*
D000900:Anti-Bacterial Agents; C000606589:CALCA protein, human; D011498:Protein Precursors; D014241:Trichloroethylene; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide