Anti-proliferative activity of hop-derived prenylflavonoids against human cancer cell lines.
Flavonoids form a substantial group of secondary plant metabolites that display several health-promoting effects. Therefore, prenylflavonoids, a subclass of flavonoids, have attracted increasing attention. Here, we investigated the possible anti-cancer potential of 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN), two prenylflavonoids present in hops and beer and demonstrate an unexpectedly pronounced, dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and UO.31 renal carcinoma cells upon treatment. Based on these findings 6-PN and 8-PN are currently further clinically evaluated in detail.
Division of Dermatologic Oncology, Department of Dermatology and Allergology, University of Tuebingen, Tuebingen, Germany.
Christian
C
Busch
Seema
S
Noor
Christian
C
Leischner
Markus
M
Burkard
Ulrich M
UM
Lauer
Sascha
S
Venturelli
D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D044950:Flavanones / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D027582:Humulus; D008517:Phytotherapy; D014407:Tumor Cells, Cultured / Q000187:drug effects*
C521871:6-prenylnaringenin; C119737:8-prenylnaringenin; D000970:Antineoplastic Agents; D044950:Flavanones; D005419:Flavonoids