The importance of codon-anticodon interactions in translation elongation.
Translation is the process by which genetic information is turned into amino acid sequence, following the instructions of the genetic code. The formation of a correct codon-anticodon pair is essential to ensure efficiency and fidelity during translation. Here we review the influence that codon-anticodon interactions play over the elongation phase of translation; including the role of this interaction in cognate tRNA selection by ribosomes, the importance of relative codon frequencies in the cell, and the roles of tRNA modifications in the process of codon-anticodon recognition.
Omnia Molecular S.L., c/ Baldiri Reixac 15-21, 08028 Barcelona, Spain. Electronic address: asaintleger@omniamol.com.
Adélaïde
A
Saint-Léger
Omnia Molecular S.L., c/ Baldiri Reixac 15-21, 08028 Barcelona, Spain; Institute for Research in Biomedicine (IRB Barcelona), c/ Baldiri Reixac 10, 08028 Barcelona, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluis Companys 23, 08010 Barcelona, Spain. Electronic address: lluis.ribas@irbbarcelona.org.
Lluís
L
Ribas de Pouplana
D000818:Animals; D000926:Anticodon; D020029:Base Pairing; D001483:Base Sequence; D003062:Codon; D005786:Gene Expression Regulation; D006801:Humans; D010441:Peptide Chain Elongation, Translational; D012323:RNA Processing, Post-Transcriptional; D012343:RNA, Transfer / Q000502:physiology
D000926:Anticodon; D003062:Codon; D012343:RNA, Transfer
Codon usage; Codon–anticodon interactions; Efficiency and fidelity; Translation elongation; tRNA modifications