Detrimental role of prolonged sleep deprivation on adult neurogenesis.
Adult mammalian brains continuously generate new neurons, a phenomenon called adult neurogenesis. Both environmental stimuli and endogenous factors are important regulators of adult neurogenesis. Sleep has an important role in normal brain physiology and its disturbance causes very stressful conditions, which disrupt normal brain physiology. Recently, an influence of sleep in adult neurogenesis has been established, mainly based on sleep deprivation studies. This review provides an overview on how rhythms and sleep cycles regulate hippocampal and subventricular zone neurogenesis, discussing some potential underlying mechanisms. In addition, our review highlights some interacting points between sleep and adult neurogenesis in brain function, such as learning, memory, and mood states, and provides some insights on the effects of antidepressants and hypnotic drugs on adult neurogenesis.
Faculty of Medicine, University of Porto Porto, Portugal ; Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto Porto, Portugal.
Carina
C
Fernandes
School of Health Technologies, Polytechnic Institute of Porto Porto, Portugal.
Nuno Barbosa F
NB
Rocha
School of Accounting and Administration of Porto, Polytechnic Institute of Porto Porto, Portugal.
Susana
S
Rocha
Unidad de Trastornos del Movimiento y Sueño, Hospital General Dr. Manuel Gea González/Instituto de Fisiología Celular, Universidad Nacional Autónoma de México Mexico City, Mexico.
Andrea
A
Herrera-Solís
Instituto de Investigación Científica, Universidad Juárez del Estado de Durango Durango, Mexico.
José
J
Salas-Pacheco
Departamento de Biomedicina, Instituto de Ciencias de la Salud, Universidad Veracruzana Xalapa, Mexico.
Fabio
F
García-García
División Ciencias de la Salud, Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Universidad Anáhuac Mayab Mérida, México.
Eric
E
Murillo-Rodríguez
School of Psychology, Nanjing Normal University Nanjing, China.
Ti-Fei
TF
Yuan
Panic and Respiration, Institute of Psychiatry of Federal University of Rio de Janeiro Rio de Janeiro, Brazil ; Physical Activity Neuroscience, Physical Activity Sciences Postgraduate Program, Salgado de Oliveira University Niterói, Brazil.
Sergio
S
Machado
Unidad de Trastornos del Movimiento y Sueño, Hospital General Dr. Manuel Gea González/Instituto de Fisiología Celular, Universidad Nacional Autónoma de México Mexico City, Mexico.
Oscar
O
Arias-Carrión
adult neurogenesis; antidepressants; circadian rhythms; hippocampus; hypnotic drugs; sleep