Keeping methylation at bay.
A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation can invade these elements is therefore important for understanding developmental gene regulation and disease. A new study shows that FBXL10, a protein commonly altered by mutation in leukemia, is part of a mechanism that blocks methylation of CpG islands.
Epigenetics Programme, Babraham Institute, Cambridge, UK, and at the Centre for Trophoblast Research, University of Cambridge, Cambridge, UK.
Gavin
G
Kelsey
D000818:Animals; D019175:DNA Methylation; D044783:F-Box Proteins / Q000502:physiology*; D056484:Jumonji Domain-Containing Histone Demethylases / Q000502:physiology*; D008297:Male; D063146:Polycomb-Group Proteins / Q000378:metabolism*; D011401:Promoter Regions, Genetic
D044783:F-Box Proteins; D063146:Polycomb-Group Proteins; D056484:Jumonji Domain-Containing Histone Demethylases