New insights into androgenic immune regulation.
Androgens negatively affect both central and peripheral immunity. Their potent immunosuppressive ability is thought to lead to gender dimorphism in autoimmune and infectious disease and hamper immunosurveillance of tumors. Therefore, we investigated the molecular underpinnings of androgens suppression of T-cell differentiation and found evidence that developing strategies to counteract these inhibitory effects may foster successful cancer immunotherapy in the future.
Department of Surgery; Beth Israel Deaconess Medical Center; Harvard Medical School ; Boston, MA USA.
Mohamed Simo
MS
Arredouani
PTPN1 phosphatase; androgens; immunosuppression; lymphocyte differentiation