Metabolic control of signalling pathways and metabolic auto-regulation.
Metabolic alterations have emerged as an important hallmark in the development of various diseases. Thus, understanding the complex interplay of metabolism with other cellular processes such as cell signalling is critical to rationally control and modulate cellular physiology. Here, we review in the context of mammalian target of rapamycin, AMP-activated protein kinase and p53, the orchestrated interplay between metabolism and cellular signalling as well as transcriptional regulation. Moreover, we discuss recent discoveries in auto-regulation of metabolism (i.e. how metabolic parameters such as metabolite levels activate or inhibit enzymes and thus metabolic pathways). Finally, we review functional consequences of post-translational modification on metabolic enzyme abundance and/or activities.
Vesalius Research Center, VIB, Leuven, 3000, Belgium.|Department of Oncology, KU Leuven, Leuven, 3000, Belgium.
Doriane
D
Lorendeau
Vesalius Research Center, VIB, Leuven, 3000, Belgium.|Department of Oncology, KU Leuven, Leuven, 3000, Belgium.
Stefan
S
Christen
Vesalius Research Center, VIB, Leuven, 3000, Belgium.|Department of Oncology, KU Leuven, Leuven, 3000, Belgium.
Gianmarco
G
Rinaldi
Vesalius Research Center, VIB, Leuven, 3000, Belgium.|Department of Oncology, KU Leuven, Leuven, 3000, Belgium.
Sarah-Maria
SM
Fendt
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D053858:Metabolic Networks and Pathways; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction
Cancer Metabolism; Mass Action Kinetics; Metabolic Regulation; Post-translational Modifications; Signaling Pathways