An efficient nano-based theranostic system for multi-modal imaging-guided photothermal sterilization in gastrointestinal tract.
Since understanding the healthy status of gastrointestinal tract (GI tract) is of vital importance, clinical implementation for GI tract-related disease have attracted much more attention along with the rapid development of modern medicine. Here, a multifunctional theranostic system combining X-rays/CT/photothermal/photoacoustic mapping of GI tract and imaging-guided photothermal anti-bacterial treatment is designed and constructed. PEGylated W18O49 nanosheets (PEG-W18O49) are created via a facile solvothermal method and an in situ probe-sonication approach. In terms of excellent colloidal stability, low cytotoxicity, and neglectable hemolysis of PEG-W18O49, we demonstrate the first example of high-performance four-modal imaging of GI tract by using these nanosheets as contrast agents. More importantly, due to their intrinsic absorption of NIR light, glutaraldehyde-modified PEG-W18O49 are successfully applied as fault-free targeted photothermal agents for imaging-guided killing of bacteria on a mouse infection model. Critical to pre-clinical and clinical prospects, long-term toxicity is further investigated after oral administration of these theranostic agents. These kinds of tungsten-based nanomaterials exhibit great potential as multi-modal contrast agents for directed visualization of GI tract and anti-bacterial agents for phothothermal sterilization.
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.
Zhen
Z
Liu
Department of Radiology, The Second Hospital of Jilin University, Changchun 130041, China.
Jianhua
J
Liu
Cold Spring Biotech Corp., Beijing 100037, China.
Rui
R
Wang
College of Life Science, Jilin University, Changchun, Jilin 130012, China.
Yingda
Y
Du
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. Electronic address: jren@ciac.ac.cn.
Jinsong
J
Ren
Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. Electronic address: xqu@ciac.ac.cn.
Xiaogang
X
Qu
D000162:Acoustics; D000284:Administration, Oral; D000818:Animals; D001424:Bacterial Infections / Q000628:therapy*; D001835:Body Weight; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000378:metabolism; D003287:Contrast Media / Q000737:chemistry; D004203:Disinfection / Q000379:methods; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology*; D005976:Glutaral / Q000737:chemistry; D057809:HEK293 Cells; D006367:HeLa Cells; D006461:Hemolysis; D006801:Humans; D006979:Hyperthermia, Induced; D051379:Mice; D064847:Multimodal Imaging / Q000295:instrumentation* / Q000379:methods; D049329:Nanostructures / Q000737:chemistry; D010789:Phototherapy / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D000068936:Theranostic Nanomedicine / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014414:Tungsten / Q000737:chemistry; D017973:Tungsten Compounds / Q000737:chemistry
D003287:Contrast Media; D017973:Tungsten Compounds; D011092:Polyethylene Glycols; D005976:Glutaral; D014414:Tungsten
Gastrointestinal tract; Long-term toxicity; Multi-modal imaging; Nanoagents; Photothermal sterilization