Clinical implications of increased Nogo-B levels in patients with acute coronary syndromes and stable angina pectoris.
Although the relationship between arteriosclerosis and inflammatory response has been recognized in recent years, little is known regarding the change in plasma Nogo-B in coronary artery disease (CAD). Thus, we investigated the expression levels of Nogo-B in CAD patients and examined this relation with disease stages. We recruited 92 CAD patients including 64 with acute coronary syndromes (ACS) and 28 with stable angina pectoris (SAP) cases and 28 healthy controls. The serum concentrations of Nogo-B were measured by enzyme-linked immunosorbent assay (ELISA). The plasma Nogo-B level was significantly higher in patients with ACS and SAP when compared with the healthy controls (both P < 0.05). Multivariate logistic regression analysis revealed that the level of Nogo-B was associated with CAD (odds ratio 1.006, 95% CI: 1.000-1.013, P < 0.05). In conclusion, an increased plasma Nogo-B level may be associated with CAD.
Department of Cardiology, and  Hangzhou Hospital, Nanjing Medical University, Hangzhou, China.
Beibei
B
Gao
Yizhou
Y
Xu
Jianhang
J
Leng
Keyi
K
Wang
Bohou
B
Xia
Jinyu
J
Huang
D054058:Acute Coronary Syndrome / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009185:Myelin Proteins / Q000097:blood*; D000070798:Nogo Proteins; D011237:Predictive Value of Tests; D012044:Regression Analysis
D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human