MicroRNA-155 hallmarks promising accuracy for the diagnosis of various carcinomas: results from a meta-analysis.
BACKGROUND
Recent studies have shown that microRNAs (miRNAs) have diagnostic values in various cancers. This meta-analysis seeks to summarize the global diagnostic role of miR-155 in patients with a variety of carcinomas.


METHODS
Eligible studies were retrieved by searching the online databases, and the bivariate meta-analysis model was employed to generate the summary receiver operator characteristic (SROC) curve.


RESULTS
A total of 17 studies dealing with various carcinomas were finally included. The results showed that single miR-155 testing allowed for the discrimination between cancer patients and healthy donors with a sensitivity of 0.82 (95% CI: 0.73-0.88) and specificity of 0.77 (95% CI: 0.70-0.83), corresponding to an area under curve (AUC) of 0.85, while a panel comprising expressions of miR-155 yielded a sensitivity of 0.76 (95% CI: 0.68-0.82) and specificity of 0.82 (95% CI: 0.77-0.86) in diagnosing cancers. The subgroup analysis displayed that serum miR-155 test harvested higher accuracy than plasma-based assay (the AUC, sensitivity, and specificity were, resp., 0.87 versus 0.73, 0.78 versus 0.74, and 0.77 versus 0.70).


CONCLUSIONS
Our data suggest that single miR-155 profiling has a potential to be used as a screening test for various carcinomas, and parallel testing of miR-155 confers an improved specificity compared to single miR-155 analysis.
Department of Preventive Medicine, Fujian Province Key Lab of Environment and Health, Institution of Environment and Health, Major Subject of Environment and Health of Fujian Key Universities, School of Public Health, Fujian Medical University, No. 1 Xue Yuan Road, University Town, Fuzhou, Fujian 350108, China.
Chuancheng
C
Wu
School of Postgraduate Education, Fujian Medical University, No. 1 Xue Yuan Road, University Town, Fuzhou, Fujian 350108, China.
Qiuyan
Q
Liu
Department of Preventive Medicine, Fujian Province Key Lab of Environment and Health, Institution of Environment and Health, Major Subject of Environment and Health of Fujian Key Universities, School of Public Health, Fujian Medical University, No. 1 Xue Yuan Road, University Town, Fuzhou, Fujian 350108, China.
Baoying
B
Liu
D002277:Carcinoma / Q000097:blood*; D016022:Case-Control Studies; D006801:Humans; D035683:MicroRNAs / Q000097:blood*; D011237:Predictive Value of Tests; D012372:ROC Curve
C524942:MIRN155 microRNA, human; D035683:MicroRNAs