[Vascular Calcification - Pathological Mechanism and Clinical Application - . Vascular calcification as a clinical manifestation of bone-vascular axis].
Several clinical studies has been shown the close relationship between osteoporosis and arteriosclerosis, and basic researches confirmed the reasonability of this association by the findings that organized molecular mechanism of bone formation in bone tissue was also observed in the lesion of vascular calcification, RANK/RANKL/OPG axis is one of potent and explainable molecular mechanism for bone-vascular association. However, one recent clinical intervetion study using RANKL antibody for post menopauisal women with primary osteoporosis could not validate that relationship. Further examinations are needed to improve understanding of the precise mechanism in this area.
Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
Masahiro
M
Yamamoto
D000818:Animals; D001161:Arteriosclerosis; D001842:Bone and Bones / Q000378:metabolism; D006801:Humans; D010012:Osteogenesis / Q000235:genetics*; D010024:Osteoporosis; D053244:Osteoprotegerin / Q000502:physiology*; D053245:RANK Ligand / Q000502:physiology*; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000502:physiology*; D061205:Vascular Calcification / Q000235:genetics*
D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B