Follicular dendritic cell sarcoma of the head and neck: Case report, literature review, and pooled analysis of 97 cases.
Follicular dendritic cell sarcoma (FDCS) is a rare lymphoid neoplasm presenting in the head and neck. There are no pooled analyses of head and neck FDCS cases in the English language literature.



A MEDLINE and PubMed review of cases from 1978 to February 2014 was performed. Demographics, clinicopathologic data, and outcomes were summarized.



We presented 2 patients and analyzed 97 cases. The mean age was 42.7 years (SD = 16.3 years). Outcomes were available for 76 patients. Tumors ≤4 cm had better disease-free survival (63% vs 28% at 5 years; p = .0282). Locoregional recurrence was significantly less likely with surgery and radiation compared to surgery alone (15% vs 45%; p = .019) and in patients receiving a neck dissection (10% vs 43%; p = .046).



This pooled analysis provides the largest sample size of FDCS of the head and neck to date and suggests that radiation and neck dissection may be beneficial to locoregional oncologic control. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2241-E2249, 2016.
Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland.
John
J
Pang
Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland.
Wojciech K
WK
Mydlarz
Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland.
Zhen
Z
Gooi
Department of Pathology, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland.
Kevin M
KM
Waters
Department of Pathology, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland.
Justin
J
Bishop
Milton J. Dance Jr. Head and Neck Cancer Center, Johns Hopkins Head and Neck Surgery, Baltimore, Maryland.
James J
JJ
Sciubba
Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland.
Young J
YJ
Kim
Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland.|Milton J. Dance Jr. Head and Neck Cancer Center, Johns Hopkins Head and Neck Surgery, Baltimore, Maryland.
Carole
C
Fakhry
D000328:Adult; D054740:Dendritic Cell Sarcoma, Follicular / Q000532:radiotherapy* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local; D016896:Treatment Outcome
dendritic cell; follicular dendritic cell sarcoma (FDCS); head and neck; sarcoma