[Vascular Calcification - Pathological Mechanism and Clinical Application - . Vascular calcification in aged mice].
Vascular calcification is a risk factor for cerebral and cardiovascular events and has a high prevalence among elderly. To finding ways of prevent or cure vascular calcification may leads to not only a healthy longevity but also medical expenditure reduction. However, the molecular mechanism underlying this pathogenic process is still obscure. To clarify the mechanism of vascular calcification, the development of animal models that exhibit extensive and robust vascular calcification is an important issue for research in vascular biology.
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan.
Takuyu
T
Akiyoshi
Sumito
S
Ogawa
Masahiro
M
Akishita
D000375:Aging / Q000235:genetics / Q000473:pathology*; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000502:physiology; D002148:Calmodulin-Binding Proteins / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology; D002454:Cell Differentiation / Q000235:genetics; D002561:Cerebrovascular Disorders / Q000209:etiology; D050659:Core Binding Factor Alpha 1 Subunit / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D010006:Osteoblasts / Q000166:cytology; D053244:Osteoprotegerin / Q000502:physiology; D053245:RANK Ligand / Q000502:physiology; D012307:Risk Factors; D061205:Vascular Calcification / Q000235:genetics* / Q000473:pathology
C525719:Bmp2 protein, mouse; D055396:Bone Morphogenetic Protein 2; D002148:Calmodulin-Binding Proteins; D050659:Core Binding Factor Alpha 1 Subunit; D053244:Osteoprotegerin; D053245:RANK Ligand