The protective effect of curcumin administration on carbon tetrachloride (CCl4)-induced nephrotoxicity in rats.
BACKGROUND
The aim of the present study was to examine the protective effect of curcumin (CUR) on carbon tetrachloride (CCl4)-induced nephrotoxicity to evaluate the detailed mechanisms by which CUR exerts its protective action.


METHODS
Thirty male Wistar-Albino rats weighing 250-300 g were randomly divided into three groups: administrations of olive oil (control, po), CCl4 (0.5mg/kg in olive oil sc) every other day for 3 weeks, and CCl4 (0.5mg/kg in olive oil sc) plus CUR (200mg/kg) every day for 3 weeks.


RESULTS
Administration of CCl4 significantly (p<0.001) increased the levels of renal function test such as creatinine and blood urea nitrogen (BUN). Furthermore, treatment of CCl4 significantly elevated the oxidant status of renal tissues while decreasing its anti-oxidant status (p<0.001). CUR displayed a renal protective effect as evident by significant decrease in inflammation and apoptosis during histopathological examination. The administration of CCl4 resulted in an increase in malondialdehyde (MDA) production due to an increase in membrane lipid peroxidation; however, the administration of CUR attenuated this, probably via its antioxidant and free radical scavenging properties.


CONCLUSIONS
The finding of our study indicates that CUR may have an important role to play in protecting the kidney from oxidative insult.
Department of Medical Biochemistry, School of Medicine, Balikesir University, Balikesir, Turkey. Electronic address: ahismiogullari@gmail.com.
Adnan A
AA
Hismiogullari
Department of Pharmacology and Toxicology, School of Veterinary Medicine, Balkesir University, Balikesir, Turkey.
Sahver E
SE
Hismiogullari
Department of Anatomy, School of Medicine, Balikesir University, Balikesir, Turkey.
Omur
O
Karaca
Department of Histology and Embryology, School of Medicine, Balikesir University, Balikesir, Turkey.
Fatma B
FB
Sunay
Department of Pathology, School of Medicine, Balikesir University, Balikesir, Turkey.
Serpil
S
Paksoy
Department of Anatomy, School of Veterinary Medicine, Balikesir University, Balikesir, Turkey.
Mehmet
M
Can
Department of Anatomy, School of Medicine, Balikesir University, Balikesir, Turkey.
Iter
I
Kus
Department of Medical Biochemistry, School of Medicine, Balikesir University, Balikesir, Turkey.
Kamil
K
Seyrek
Department of Medical Biochemistry, School of Medicine, Balikesir University, Balikesir, Turkey.
Ozlem
O
Yavuz
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D002251:Carbon Tetrachloride / Q000633:toxicity*; D003474:Curcumin / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D020011:Protective Agents; D002251:Carbon Tetrachloride; D003474:Curcumin
Antioxidant; Carbon tetrachloride; Curcumin; Nephroprotection