Comparative Distribution, Correlation, and Chemometric Analyses of Selected Metals in Scalp Hair of Angina Patients and Healthy Subjects.
Numerous epidemiological studies are preponderance of evidences intimating development of coronary artery disease caused by metal imbalance. The present study was aimed to analyze Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Na, Pb, Sr, and Zn in the scalp hair of angina patients and healthy subjects/controls employing HNO3-HCLO4-based wet digestion followed by quantification with atomic absorption spectrophotometry. The average concentrations of Cd, Cu, Cr, Fe, Mn, Pb, and Sr revealed significantly higher levels in scalp hair of patients than controls; however, Na and Zn were appreciably higher in healthy subjects. Dissimilarity in the trace metal distribution was also observed with gender, residence, dietary habits, and smoking habits of both donor groups. The correlation study and multivariate analyses revealed diverse mutual relationships and apportionment of the trace metals in the scalp hair of patients and controls.
Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Asim
A
Ilyas
Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Hamad
H
Ahmad
Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan. mhshahg@qau.edu.pk.
Munir H
MH
Shah
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000453:epidemiology / Q000378:metabolism*; D004032:Diet; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008297:Male; D008670:Metals / Q000032:analysis / Q000378:metabolism*; D008875:Middle Aged; D010154:Pakistan / Q000453:epidemiology; D012424:Rural Population; D012727:Sex Characteristics; D013054:Spectrophotometry, Atomic; D064424:Tobacco Use / Q000453:epidemiology; D014131:Trace Elements / Q000032:analysis; D014505:Urban Population
D008670:Metals; D014131:Trace Elements
AAS; Angina; Multivariate analysis; Scalp hair; Trace metals