Cardiovascular risk in relation to a new classification of hypertensive left ventricular geometric abnormalities.
OBJECTIVE
In 2010, the Dallas Heart Study proposed an upgrade of the left ventricular geometric classification proposed in 1991, by using left ventricular mass combined with end diastolic volumes, and introducing the new categories of dilated left ventricular hypertrophy (LVH). We adopted the new method to test the prognostic impact of the left ventricular geometric patterns from the new classification.


METHODS
We evaluated baseline anthropometric, laboratory and echocardiographic parameters of 8848 hypertensive patients from the Campania Salute Network (53 ± 12 years, 56% male), free of prevalent cardiovascular disease, valve disease and with ejection fraction ≥50%. Cut points for left ventricular mass index, relative wall thickness and left ventricular end-diastolic dimension (cm/m) were derived from our historical normal reference population. Composite cardiovascular end-points were cardiac death, fatal and nonfatal myocardial infarction and stroke.


RESULTS
Independent of confounders, eccentric dilated LVH, concentric nondilated LVH and concentric dilated LVH were associated with higher cardiovascular risk (hazard ratios between 2 and 9, all P < 0.01), mostly depending on the magnitude of LVM index. A volume load was present especially in dilated forms of LVH, the extent of which was important in the determination of harmful types of left ventricular geometry.


CONCLUSIONS
Consideration of left ventricular dilatation in the evaluation of risk related to hypertensive left ventricular geometry reveals the importance of the extent of the volume load coexisting with the typical hypertensive pressure overload. At a given normal ejection fraction, the balance between the two hemodynamic components influences the shape of left ventricular geometric adaptation, the amount of left ventricular mass and the impact on prognosis.
aHypertension Research Center bDepartment of Translational Medical Sciences, Federico II University, Naples, Italy cDivision of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA dDepartment of Medicine and Surgery, University of Salerno, Salerno eDepartment of Neurosciences; Federico II University, Naples fDepartment of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Giovanni
G
de Simone
Raffaele
R
Izzo
Gerard P
GP
Aurigemma
Marina
M
De Marco
Francesco
F
Rozza
Valentina
V
Trimarco
Eugenio
E
Stabile
Nicola
N
De Luca
Bruno
B
Trimarco
D000328:Adult; D000368:Aged; D016757:Death, Sudden, Cardiac / Q000453:epidemiology*; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000453:epidemiology*; D017379:Hypertrophy, Left Ventricular / Q000145:classification / Q000000981:diagnostic imaging / Q000453:epidemiology*; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000401:mortality; D015995:Prevalence; D011379:Prognosis; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology*