Chromosomal analysis of couples with repeated spontaneous abortions in northeastern iran.
BACKGROUND
Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs). The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously.


METHODS
In this retrospective study, the pattern of chromosomal aberrations was evaluated during a six-year period from 2005 to 2011. The population under study was 728 couples who attended genetic counseling services for their RSAs at Pardis Clinical and Genetics Laboratory, Mashhad, Iran.


RESULTS
In this study, about 11.7% of couples were carriers of chromosomal aberrations. The majority of abnormalities were found in couples with history of abortion, without stillbirth or livebirth. Balanced reciprocal translocations, Robertsonian translocations, inversions and sex chromosome aneuploidy were seen in these cases. Balanced reciprocal translocations were the most frequent chromosomal anomalies (62.7%) detected in current study.


CONCLUSIONS
These findings suggest that chromosomal abnormalities can be one of the important causes of RSAs. In addition, cytogenetic study of families who experienced RSAs may prevent unnecessary treatment if RSA are caused by chromosomal abnormalities. The results of cytogenetic studies of RSA cases will provide a standard protocol for the genetic counselors in order to follow up and to help these families.
Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran ; Pardis Clinical and Genetics Laboratory, Mashhad, Iran.
Saeedeh
S
Ghazaey
Pardis Clinical and Genetics Laboratory, Mashhad, Iran.
Fatemeh
F
Keify
Pardis Clinical and Genetics Laboratory, Mashhad, Iran.
Farzaneh
F
Mirzaei
Pardis Clinical and Genetics Laboratory, Mashhad, Iran.
Masumeh
M
Maleki
Pardis Clinical and Genetics Laboratory, Mashhad, Iran.
Semiramis
S
Tootian
Pardis Clinical and Genetics Laboratory, Mashhad, Iran.
Mitra
M
Ahadian
Pardis Clinical and Genetics Laboratory, Mashhad, Iran ; Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Reza
MR
Abbaszadegan
Abortions; Chromosomal Abnormalities; Cytogenetic Analysis