[Risk factors for early disseminated intravascular coagulation in neonates with sepsis].
OBJECTIVE
To investigate the risk factors for early disseminated intravascular coagulation (DIC) in neonates with sepsis.


METHODS
A retrospective clinical study was performed on 100 neonates with a confirmed diagnosis of sepsis between 2012 and 2013. The children were classified into normal coagulation group, non-overt DIC group (early DIC group), and overt DIC group (late DIC group) based on the ISTH overt DIC scoring system. The clinical manifestations and risk factors were analyzed statistically.


RESULTS
Early DIC occurred in 44 (44%) cases in the 100 neonates with sepsis. The incidence of sclerema showed significant differences between the three groups (P<0.05). Asphyxia, bleeding, and Gram-negative bacterial infection were independent risk factors for early DIC.


CONCLUSIONS
Coagulation function should be actively monitored and early intervention measures should be taken for neonates with asphyxia, bleeding, and Gram-negative bacterial infection to prevent early DIC from progressing to late DIC.
Department of Neonatology, Second Hospital of Lanzhou University, Lanzhou 730030, China. xud@lzu.edu.cn.
Wen-Hua
WH
Wang
Ding
D
Xu
Ya-Mei
YM
Han
Zi-Jiu
ZJ
Yang
D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D012307:Risk Factors; D018805:Sepsis / Q000150:complications*