Sodium-glucose cotransporter-2 inhibition and the insulin: Glucagon ratio: Unexplored dimensions.
The sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a novel class of glucose-lowering drugs which act by inhibiting the reabsorption of filtered glucose from the kidneys. Their effect on insulin and glucagon levels has recently been studied but is not fully explained. This communication proposes various hypotheses: A direct effect of SGLT-2 inhibition on the alpha cell receptors, a paracrine or intra-islet mediated effect on alpha cell sensitivity to glucose, and a calorie restriction mimetic action, to explain the impact of these drugs on the insulin glucagon ratio.
Department of Endocrinology, Bharti Hospital and B.R.I.D.E, Karnal, Haryana, India.
Sanjay
S
Kalra
Department of Medicine, Government Medical College and Hospital, Chandigarh, India.
Yashdeep
Y
Gupta
Senior Medical Advisor, Boehringer Ingelheim, Mumbai, India.
Shiva
S
Patil
Beta cell; canagliflozin; dapagliflozin; diabetes; empagliflozin; glucagon; insulin