[Nasopharyngeal carcinoma. Brush biopsy with EBV-PCR is suitable as a screening test].
The nasopharyngeal carcinoma (NPC) is closely associated with the Epstein-Barr virus (EBV) infection. Because each tumor cell in a patient regardless of histological subtype contains an identical copy of the viral clone, the virus is easily detectable at early pre-invasive lesions. Nevertheless, the nasopharyngeal carcinoma is still usually diagnosed late, often not until they exhibit infested lymph nodes and / or distant metastases have occurred. Canadian scientists have now discovered and analyzed a new screening method.
Uta
U
Blochmann
Thomas
T
Kühnel
D001706:Biopsy / Q000379:methods*; D004279:DNA, Viral / Q000032:analysis*; D055088:Early Detection of Cancer / Q000379:methods*; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000821:virology*
D004279:DNA, Viral