Cost-Effectiveness of a Specialist Geriatric Medical Intervention for Frail Older People Discharged from Acute Medical Units: Economic Evaluation in a Two-Centre Randomised Controlled Trial (AMIGOS).
BACKGROUND
Poor outcomes and high resource-use are observed for frail older people discharged from acute medical units. A specialist geriatric medical intervention, to facilitate Comprehensive Geriatric Assessment, was developed to reduce the incidence of adverse outcomes and associated high resource-use in this group in the post-discharge period.


OBJECTIVE
To examine the costs and cost-effectiveness of a specialist geriatric medical intervention for frail older people in the 90 days following discharge from an acute medical unit, compared with standard care.


METHODS
Economic evaluation was conducted alongside a two-centre randomised controlled trial (AMIGOS). 433 patients (aged 70 or over) at risk of future health problems, discharged from acute medical units within 72 hours of attending hospital, were recruited in two general hospitals in Nottingham and Leicester, UK. Participants were randomised to the intervention, comprising geriatrician assessment in acute units and further specialist management, or to control where patients received no additional intervention over and above standard care. Primary outcome was incremental cost per quality adjusted life year (QALY) gained.


RESULTS
We undertook cost-effectiveness analysis for 417 patients (intervention: 205). The difference in mean adjusted QALYs gained between groups at 3 months was -0.001 (95% confidence interval [CI]: -0.009, 0.007). Total adjusted secondary and social care costs, including direct costs of the intervention, at 3 months were £4412 (€5624, $6878) and £4110 (€5239, $6408) for the intervention and standard care groups, the incremental cost was £302 (95% CI: 193, 410) [€385, $471]. The intervention was dominated by standard care with probability of 62%, and with 0% probability of cost-effectiveness (at £20,000/QALY threshold).


CONCLUSIONS
The specialist geriatric medical intervention for frail older people discharged from acute medical unit was not cost-effective. Further research on designing effective and cost-effective specialist service for frail older people discharged from acute medical units is needed.


BACKGROUND
ISRCTN registry ISRCTN21800480 http://www.isrctn.com/ISRCTN21800480.
School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
Lukasz
L
Tanajewski
School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
Matthew
M
Franklin
School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
Georgios
G
Gkountouras
School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
Vladislav
V
Berdunov
Division of Rehabilitation and Ageing, University of Nottingham, Nottingham, United Kingdom.
Judi
J
Edmans
Universty Hospitals of Leicester, Leicester, United Kingdom.
Simon
S
Conroy
Division of Rehabilitation and Ageing, University of Nottingham, Nottingham, United Kingdom.
Lucy E
LE
Bradshaw
Division of Rehabilitation and Ageing, University of Nottingham, Nottingham, United Kingdom.
John R F
JR
Gladman
School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
Rachel A
RA
Elliott
D000368:Aged; D000369:Aged, 80 and over; D003362:Cost-Benefit Analysis; D061345:Early Medical Intervention / Q000191:economics*; D005260:Female; D015577:Geriatric Assessment; D006769:Hospitals, General / Q000191:economics; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D010351:Patient Discharge / Q000191:economics; D019057:Quality-Adjusted Life Years; D006113:United Kingdom