[Expression of Ki-67 and P53 protein in oral squamous cell carcinoma and its clinical significance].
OBJECTIVE
To investigate the clinical and pathological features and its relationship with the expression of Ki-67 and p53 protein in oral squamous cell carcinoma.


METHODS
Immunohistochemical SP staining method was used to quantify the protein expression levels of Ki-67 and p53 protein in 10 cases of normal oral mucosa, 16 cases of oral leukoplakia (OLK) tissue, and 48 cases of oral squamous cell carcinoma. The relationship of the expression of Ki-67 and p53 protein to clinical and pathological data was analyzed, and SPSS17.0 software package was used for statistical analysis.


RESULTS
The positive expression rate of Ki-67 protein in normal oral mucosa, oral leukoplakia and oral squamous cell carcinoma was 30%, 56.3% and 79.2%, respectively; The positive expression rate of p53 was 0%, 43.8%, and 70.8%, respectively; Ki-67 and p53 expression had significant difference among normal oral mucosa, oral leukoplakia and oral squamous cell carcinoma (P<0.05); The expression of Ki-67 protein was significantly elevated with tumor stage, differentiation and cervical lymph node metastasis (P<0.05); The expression of p53 protein was significantly related to the degree of tumor differentiation (P<0.05); The expression of Ki-67 and p53 was positively correlated in oral squamous cell carcinoma (P<0.05).


CONCLUSIONS
The high expression of Ki-67 and p53 protein in oral squamous cell carcinoma tissues may play an important role in the development of oral squamous cell carcinoma.
Department of Stomatology, Hubei Vocational and Technical College. Xiaogan 432000; China.E-mail:hbzyhewei@163.com.
Wei
W
He
Yan
Y
Xiao
Wei-min
WM
Chen
D002294:Carcinoma, Squamous Cell; D002454:Cell Differentiation; D006801:Humans; D019394:Ki-67 Antigen; D007972:Leukoplakia, Oral; D008207:Lymphatic Metastasis; D009061:Mouth Mucosa; D009062:Mouth Neoplasms; D009367:Neoplasm Staging; D016159:Tumor Suppressor Protein p53
D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53