Nanoscaled boron-containing delivery systems and therapeutic agents for cancer treatment.
Significant efforts have recently been made to develop nanoscaled boron-containing delivery systems for improving drug delivery in cancer therapy. On one hand, borate ester chemistry has shown importance in ligand-mediated tumor targeting owing to the recognition ability of boronic acid to polyol residues in cell membranes. In particular, the phenylboronic acid-functionalized nanocarriers for specific targeting to sialic acid groups which are overexpressed on tumor cells have made great achievements. On the other hand, nanoscaled boron neutron capture therapy agents show growing potential in efficiently transporting boron to tumor. The current review outlines the recent developments in the application of borate ester chemistry in tumor targeting by nanoparticles, then summarizes recent work on the development of boron-based nanomaterials as boron neutron capture therapy agents.
Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, People's Republic of China.
Jing
J
Wang
Wei
W
Wu
Xiqun
X
Jiang
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001881:Borates / Q000737:chemistry / Q000378:metabolism; D001896:Boron Compounds / Q000737:chemistry* / Q000378:metabolism; D016754:Boron Neutron Capture Therapy / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D004952:Esters / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000532:radiotherapy
D000970:Antineoplastic Agents; D001881:Borates; D001896:Boron Compounds; D004337:Drug Carriers; D004952:Esters
antitumor efficiency; drug delivery; nanoparticles; phenylboronic acid; sialic acid