Relationship between Antibody-Positive Rate against Plasmodium vivax Circumsporozoite Protein and Incidence of Malaria.
The relationship between anti- Plasmodium vivax circumsporozoite protein (CSP) antibody levels and the prevalence of malaria in epidemic areas of South Korea was evaluated. Blood samples were collected from inhabitants of Gimpo-si (city), Paju-si, and Yeoncheon-gun (county) in Gyeonggi-do (province), as well as Cheorwon-gun in Gangwon-do from November to December 2004. Microscopic examinations were used to identify malaria parasites. ELISA was used to quantitate anti-circumsporozoite protein (CSP) antibodies against P. vivax. A total of 1,774 blood samples were collected. The overall CSP-ELISA-positive rate was 7.7% (n=139). The annual parasite incidences (APIs) in these areas gradually decreased from 2004 to 2005 (1.09 and 0.80, respectively). The positive rate in Gimpo (10.4%, 44/425) was the highest identified by CSP-ELISA. The highest API was found in Yeoncheon, followed by Cheorwon, Paju, and Gimpo in both years. The positive rates of CSP-ELISA were closely related to the APIs in the study areas. These results suggest that seroepidemiological studies based on CSP may be helpful in estimating the malaria prevalence in certain areas. In addition, this assay can be used to establish and evaluate malaria control and eradication programs in affected areas.
Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, FL 32610, USA.
Hyeong-Woo
HW
Lee
Department of Biomedical Science, Jungwon University, Goesan, Chungbuk 367-805, Korea.
Yoon-Joong
YJ
Kang
Division of Malaria and Parasitic Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, Osong 363-951, Korea.
Shin-Hyeong
SH
Cho
Department of Parasitology and Tropical Medicine and Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 660-751, Korea.
Byoung-Kuk
BK
Na
Asan Institute for Life Sciences, University of Ulsan College of Medicine Asan Medical Center, Seoul 138-736, Korea.
Jhang Ho
JH
Pak
Department of Parasitology, College of Medicine, Catholic University of Korea, Seoul 137-701, Korea.
Ho-Woo
HW
Nam
Department of Parasitology and Tropical Medicine and Inha Research Institute for Medical Sciences, Inha University School of Medicine, Incheon 400-712, Korea.
Yun-Kyu
YK
Park
Department of Anatomy, College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, Seoul 130-701, Korea.
Youngjoo
Y
Sohn
Department of Parasitology and Tropical Medicine and Inha Research Institute for Medical Sciences, Inha University School of Medicine, Incheon 400-712, Korea.
Tong-Soo
TS
Kim
D000293:Adolescent; D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015994:Incidence; D016780:Malaria, Vivax / Q000097:blood* / Q000453:epidemiology* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010966:Plasmodium vivax / Q000276:immunology* / Q000502:physiology; D015995:Prevalence; D015800:Protozoan Proteins / Q000276:immunology; D056910:Republic of Korea / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D055815:Young Adult
D000913:Antibodies, Protozoan; D015800:Protozoan Proteins
Plasmodium vivax; annual parasite incidence; circumsporozoite protein; seropositivity