Successful autologous hematopoietic stem cell transplantation for a patient with rapidly progressive localized scleroderma.
Autologous hematopoietic stem cell transplant (HSCT) for rapidly progressive disease has not been reported in localized scleroderma. Our patient, a 16-year-old girl had an aggressive variant of localized scleroderma, mixed subtype (linear-generalized) with Parry Romberg syndrome, with no internal organ involvement, that was unresponsive to immunosuppressive therapy and was causing rapid disfigurement. She was administered autologous HSCT in June 2011 and has maintained drug-free remission with excellent functional status at almost 3.5 years of follow-up.
Armed Forces Medical College, Pune, India.
Velu
V
Nair
Ajay
A
Sharma
Sanjeevan
S
Sharma
Satyaranjan
S
Das
Darshan S
DS
Bhakuni
Krishnan
K
Narayanan
Vivek
V
Nair
Subramanian
S
Shankar
D000293:Adolescent; D001706:Biopsy; D018450:Disease Progression; D005150:Facial Hemiatrophy / Q000209:etiology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D012074:Remission Induction; D012594:Scleroderma, Localized / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome
autologous; localised scleroderma; stem cell transplantation