ECD kidney transplantation outcomes are improved when matching donors to recipients using a novel creatinine clearance match ratio (CCMR).
Improved outcomes have been associated with various methods of size matching between expanded criteria (ECD) donors and recipients. A novel method for improved functional based matching was developed utilizing manipulation of Cockcroft-Gault estimated creatinine clearances for donor and recipient. We hypothesized that optimal clearance-based matches would have superior outcomes for both immediate graft function and long-term graft survival. For the analysis, recipients of ECD kidneys in the Scientific Registry of Transplant Recipients (SRTR) transplanted between October 1, 1987 and August 31, 2011 were included. Univariate and multivariate analyses predicted the hazard ratio of graft failure and the odds ratio of requiring dialysis within the first week. A total of 25,640 ECD kidney transplants were analyzed. On multivariate analysis, higher creatinine clearance match ratio (CCMR) was associated with increased graft failure and odds of requiring dialysis within the first week (comparing highest ratio quintile versus lowest ratio quintile: HR 1.43, p < 0.001; OR 2.08, p < 0.001). This study suggests that ECD kidneys have improved outcomes when the recipient/donor CCMR is optimized.
Department of Surgery, University of California, San Diego, CA, USA.
Jamie E
JE
Anderson
Department of Medicine, University of California, San Diego, CA, USA.
Robert W
RW
Steiner
Department of Surgery, University of California, San Diego, CA, USA.
Kristin L
KL
Mekeel
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
David C
DC
Chang
Department of Surgery, University of California, San Diego, CA, USA.
Alan W
AW
Hemming
Department of Surgery, University of California, San Diego, CA, USA.
Jeffrey B
JB
Halldorson
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D046148:Donor Selection / Q000379:methods* / Q000592:standards; D005260:Female; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000401:mortality / Q000601:surgery*; D016030:Kidney Transplantation / Q000401:mortality; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D015999:Multivariate Analysis; D012372:ROC Curve; D012042:Registries; D016896:Treatment Outcome
D015415:Biomarkers; D003404:Creatinine
creatinine clearance; end-stage renal disease; extended criteria donor; kidney transplantation; surgical outcomes