Estimation of Young's modulus of pharmaceutical tablet obtained by terahertz time-delay measurement.
In this paper, it is suggested that Young's modulus of pharmaceutical tablets with different porosity can be estimated from terahertz (THz) pulse time delay. We demonstrate such a possibility using a training set of tablets compressed from starch acetate. Once the mechanical properties are taught to the THz measurement system, using an ideal tablet as a reference, it is possible to get information about the Young's modulus of the tablet. Here, we show that there are optical counterparts of classical mechanical laws that couple the Young's modulus and porosity of the tablet.
Institute of Photonics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland. Electronic address: kai.peiponen@uef.fi.
Kai-Erik
KE
Peiponen
Institute of Photonics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland.
Prince
P
Bawuah
Institute of Photonics, University of Eastern Finland, P.O. Box 111, FI-80101 Joensuu, Finland.
Mousumi
M
Chakraborty
Photonics Devices and Measurement Solutions, VTT Technical Research Center of Finland, Kuopio, Finland.
Mikko
M
Juuti
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB2 3RA, United Kingdom.
J Axel
JA
Zeitler
School of Pharmacy, Promis Centre, University of Eastern Finland, P. O. Box 1617, FI-70211, Kuopio, Finland.
Jarkko
J
Ketolainen
D055119:Elastic Modulus; D016062:Porosity; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical; D055068:Terahertz Spectroscopy
D013607:Tablets
Pharmaceutical tablet; Porosity; Refractive index; Spriggs law; Terahertz pulse; Young’s modulus