Ultrasonographic characteristics and BI-RADS-US classification of BRCA1 mutation-associated breast cancer in Guangxi, China.
OBJECTIVE
To retrospectively analyze and compare the ultrasonographic characteristics and BI-RADS-US classification between patients with BRCA1 mutation-associated breast cancer and those without BRCA1 gene mutation in Guangxi, China.


METHODS
The study was performed in 36 lesions from 34 BRCA1 mutation-associated breast cancer patients. A total of 422 lesions from 422 breast cancer patients without BRCA1 mutations served as control group. The comparison of the ultrasonographic features and BI-RADS-US classification between two the groups were reviewed.


RESULTS
More complex inner echo was disclosed in BRCA1 mutation-associated breast cancer patients (x(2) = 4.741, P = 0.029). The BI-RADS classification of BRCA1 mutation-associated breast cancer was lower (U = 6094.0, P = 0.022).


CONCLUSIONS
BRCA1 mutation-associated breast cancer frequently displays as microlobulated margin and complex echo. It also shows more benign characteristics in morphology, and the BI-RADS classification is prone to be underestimated.
Department of Diagnostic Ultrasound, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.
Cheng
C
Li
Department of Diagnostic Ultrasound, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.
Junjie
J
Liu
Department of Diagnostic Ultrasound, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.
Sida
S
Wang
Department of Diagnostic Ultrasound, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.
Yuanyuan
Y
Chen
Department of Diagnostic Ultrasound, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.
Zhigang
Z
Yuan
Department of Diagnostic Ultrasound, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.
Jian
J
Zeng
Department of Diagnostic Ultrasound, First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.
Zhixian
Z
Li
BRCA1 gene; Breast cancer; elastography; mutations; ultrasonography