[On the role of opioid system of myocardium in the implementation of the cardioprotective effect of postconditioning].
Investigated the involvement of the endogenous opioid agonists attack in the implementation of the cardioprotective effect of postconditioning, playing with the model of isolated perfused on Langendorf rat heart. It is established that this phenomenon occurs when using three sessions reperfusion (30 s) and ischemia (30 s) played at the end of the period 45-min global ischemia. Using the selective blocker of different subtypes of opioid receptors, which was added in perfusion solution in early reperfusion period, found that the stability of the heart to action ischemia-reperfusion in ischemic postconditioning is implemented through the activation of the Delta-1 opioid receptor. Suggests that the mechanism cardioproteguoe phenomenon of postconditioning significant role belongs synthesized in the myocardium of endogenous opioids.
T V
TV
Lasukova
L N
LN
Maslov
A S
AS
Gorbunov
D000701:Analgesics, Opioid / Q000819:agonists / Q000378:metabolism*; D000818:Animals; D019157:Ischemic Preconditioning, Myocardial; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D009924:Organ Culture Techniques; D051381:Rats
D000701:Analgesics, Opioid