Childhood lupus with microangiopathic antiphospholipid syndrome and pulmonary hemorrhage.
BACKGROUND
Concurrent thrombotic and hemorrhagic manifestations are uncommon in patients with Antiphospholipid Syndrome.


METHODS
A 10-year-old girl with fever, edema, rash and joint pains, who later developed deep venous thrombosis (DVT), stroke, thrombotic microangiopathic hemolytic anemia and pulmonary hemorrhage. Investigations confirmed Antiphospholipid syndrome associated with systemic lupus erythematosus.


RESULTS
She went into complete remission with intravenous immunoglobulins, plasmapheresis, immunosuppression and anticoagulation.


CONCLUSIONS
Thrombotic microangiopathic hemolytic anemia and anti-phospholipid syndrome can be the presenting manifestations of systemic lupus erythematosus.
Departments of Nephrology and *Renal Transplantation, SGPGI, Lucknow, Uttar Pradesh, India. Correspondence to: Dr Dharmendra Bhadauria, Assistant Professor, Department of Nephrology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. drdharm1@rediffmail.com.
Dharmendra
D
Bhadauria
Praveen
P
Etta
Anupma
A
Kaul
Narayan
N
Prasad
D000743:Anemia, Hemolytic; D016736:Antiphospholipid Syndrome; D002648:Child; D005260:Female; D006470:Hemorrhage; D006801:Humans; D008171:Lung Diseases; D008180:Lupus Erythematosus, Systemic; D020246:Venous Thrombosis