Correlation of rs1799793 polymorphism in ERCC2 and the clinical response to platinum-based chemotherapy in patients with triple negative breast cancer.
BACKGROUND
Polymorphisms of DNA repair genes may affect the repair capacity of DNA damages and cause different responses towards chemotherapy. Excision repair cross-complementing group 2 (ERCC2) plays an important role in the nucleotide excision repair.


OBJECTIVE
The aim of this study was to investigate the association between ERCC2 single nucleotide polymorphisms (SNPs) and the response to platinum-based chemotherapy among patients with triple negative breast cancer.


METHODS
In total, 60 triple negative breast cancer patients treated with platinum-based chemotherapy were studied. The clinical, pathological and treatment data of them were collected. Sequenom's MassARRAY system was used in the detection of the SNPs of ERCC2. Finally, the association between genotypes and different clinical responses among patients was analyzed. All of the patients received a platinum-based chemotherapy for 4 cycles in median and achieved an overall response rate of 66.7%, showing a comparative good response towards platinum-based chemotherapy among triple negative breast cancer. Fifty-three of the 60 patients had got the results of ERCC2 rs1799793 polymorphisms after MassARRAY detection.


RESULTS
The proportion of GG genotype and GA genotype was 81.1% and 18.9% respectively. The response rate of the rs1799793 GG genotype group was 69.8%, while the GA genotype group only had a response rate of 30.0%. It turned out that the GG genotype was associated with better response towards platinum-based chemotherapy (P=0.030).


CONCLUSIONS
ERCC2 rs1799793 polymorphism may be associated with the clinical sensitivity of platinum-based chemotherapy and could be a potential predictive biomarker for triple negative breast cancer patients treated with platinum compounds.
Department of Radiotherapy, Lanzhou General Hospital of PLA 333 Binhe South Road, Lanzhou 730050, Gansu Province, PR China.
Jun
J
Lu
Department of Radiology, Xijing Hospital, Fourth Military Medical University 147 Changle Road, Xi'an 710032, Shaanxi Province, PR China.
Haitao
H
Zhao
Department of Radiotherapy, Lanzhou General Hospital of PLA 333 Binhe South Road, Lanzhou 730050, Gansu Province, PR China.
Sha
S
Li
Department of Radiotherapy, Lanzhou General Hospital of PLA 333 Binhe South Road, Lanzhou 730050, Gansu Province, PR China.
Zhongze
Z
Tian
Department of Radiotherapy, Lanzhou General Hospital of PLA 333 Binhe South Road, Lanzhou 730050, Gansu Province, PR China.
Xianghui
X
Zhu
Department of Radiotherapy, Lanzhou General Hospital of PLA 333 Binhe South Road, Lanzhou 730050, Gansu Province, PR China.
Hongyi
H
Wang
Department of Radiotherapy, Lanzhou General Hospital of PLA 333 Binhe South Road, Lanzhou 730050, Gansu Province, PR China.
Hua
H
Fu
Excision repair cross-complementing group 2; platinum-based chemotherapy; response; single nucleotide polymorphisms; triple negative breast cancer