[Efficiency of (99)Tc(m)-sestamibi in diagnosis of parathyroid diseases with primary hyperparathyroidism].
OBJECTIVE
To evaluate the efficiency of (99)Tc(m)-sestamibi (MIBI) in the diagnosis of parathyroid diseases with primary hyperparathyroidism.


METHODS
One hundred and four cases with primary hyperparathyroidism underwent MIBI and parathyroidectomy between May 2010 to November 2013 were reviewed. With MIBI, single adenoma was found in 91 cases, two adenomas in 5 cases, carcinoma and hyperplasia in 3 cases respectively. Primary hyperparathyroidism was diagnosed based on the associated symptoms and signs in 93 patients, while it was indicated in 11 asymptomatic patients due to the presence of hypercalcemia in health examination. Parathroid hormone levels ranged from 98 to 2 800 ng/L, and serum calcium levels were between 2.56-4.23 mmol/L.


RESULTS
The sensitivity of MIBI for total diseased parntyroids was 84.0% (100/119), and that for parathyroid adenoma, parnthyroid carcinoma, atypical adenoma and primary parathyroid hyperplasia was 87.1% (88/101), 3/3, 2/2 and 7/13, respectively.


CONCLUSIONS
MIBI is efficient in the diagnosis of parathyroid diseases with primary hyperparathyroidism. The size and cystic degeneration of parathroid disease are two common factors decreasing MIBI reliability, and thyroid nodule is additional source leading to false-positive results.
Departmen of Otorhinolaryngology Head and Neck Surgery, Beijng Shijitan Hospital, Capital Medical University, Beijing 100038, China. Email: weibojun1015@sina.com.
Bojun
B
Wei
Departmen of Otorhinolaryngology Head and Neck Surgery, Beijng Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Hong
H
Shen
Departmen of Otorhinolaryngology Head and Neck Surgery, Beijng Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Guansheng
G
Tong
Departmen of Otorhinolaryngology Head and Neck Surgery, Beijng Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Rengui
R
Wang
Departmen of Otorhinolaryngology Head and Neck Surgery, Beijng Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Hong
H
Chang
D000236:Adenoma; D002277:Carcinoma; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000175:diagnosis*; D006965:Hyperplasia; D010280:Parathyroid Glands; D010282:Parathyroid Neoplasms; D016105:Parathyroidectomy; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D017256:Technetium Tc 99m Sestamibi; D016606:Thyroid Nodule
D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi