Biocontainment through reengineered genetic codes.
It's only unnatural: Reengineered genetic codes can achieve biocontainment by specifying different meanings for protein sequences in modified versus natural organisms; the synthetic bacterium discussed here is dependent on unnatural amino acids because its reengineered genetic code specifies unnatural amino acids in essential genes.
Department of Biomedical Engineering, University of California at Irvine, 3120 Natural Sciences II, Irvine, CA 92697 (USA).
Arjun
A
Ravikumar
Departments of Biomedical Engineering and Chemistry, University of California at Irvine, 3105 Natural Sciences II, Irvine, CA 92697 (USA). ccl@uci.edu.
Chang C
CC
Liu
D055885:Biohazard Release / Q000517:prevention & control*; D005815:Genetic Code / Q000235:genetics*; D005818:Genetic Engineering / Q000009:adverse effects / Q000379:methods*; D008829:Microbiology; D012449:Safety
amino acids; biocontainment; genetic code; genome engineering; microbes; synthetic biology