Primary amelanotic mucosal melanoma of the oronasal region: report of two new cases and literature review.
Primary amelanotic mucosal melanoma is a rare entity with challenging histopathological features. Because these tumors are thought to be biologically more aggressive, they have a poorer prognosis than that of pigmented melanomas. In this work, we present a literature review about the clinical, histopathological, and immunohistochemical features of primary amelanotic mucosal melanoma of the oronasal region and report two new cases. Amelanotic mucosal melanoma commonly affects men in the seventh decade of life and tend to have a poor prognosis, as seen by the high incidence of metastasis, recurrences, and, ultimately, death. There is a similar pattern in the clinic-pathological predilections (such as age, gender, primary site, and metastatic potential) of amelanotic mucosal melanoma when comparing with data reported for pigmented lesions. This work reinforces knowledge about amelanotic mucosal melanomas and epidemiologic predilections. The optimal management of this lesion remains controversial.
Oral Pathology Area, School of Dentistry, Federal University of Uberlândia, Uberlândia, Brazil.|Oral and Maxillofacial Surgery Department, Clinical Hospital, Federal University of Uberlândia, Uberlândia, Brazil.
Luiz Fernando Barbosa de
LF
Paulo
Oral Pathology Area, School of Dentistry, Federal University of Uberlândia, Uberlândia, Brazil.
João Paulo Silva
JP
Servato
Oral Pathology Area, School of Dentistry, Federal University of Uberlândia, Uberlândia, Brazil.
Roberta Rezende
RR
Rosa
Oral and Maxillofacial Surgery Department, Clinical Hospital, Federal University of Uberlândia, Uberlândia, Brazil.
Maiolino Thomaz Fonseca
MT
Oliveira
Department of Morphology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil.
Paulo Rogério de
PR
Faria
Head and Neck Surgery Department, Clinical Hospital, Federal University of Uberlândia, Uberlândia, Brazil.
Sindeval José da
SJ
Silva
Oral Pathology Area, School of Dentistry, Federal University of Uberlândia, Uberlândia, Brazil.
Sergio Vitorino
SV
Cardoso
Oral Pathology Area, School of Dentistry, Federal University of Uberlândia, Uberlândia, Brazil. loyolaam@yahoo.com.br.
Adriano Mota
AM
Loyola
D000328:Adult; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D018328:Melanoma, Amelanotic / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology
Amelanotic mucosal melanomas; Malignant melanomas; Nasal cavity; Oral cavity