Left-right asymmetry in the light of TOR: An update on what we know so far.
The internal left-right (LR) asymmetry is a characteristic that exists throughout the animal kingdom from roundworms over flies and fish to mammals. Cilia, which are antenna-like structures protruding into the extracellular space, are involved in establishing LR asymmetry during early development. Humans who suffer from dysfunctional cilia often develop conditions such as heterotaxy, where internal organs appear to be placed randomly. As a consequence to this failure in asymmetry development, serious complications such as congenital heart defects (CHD) occur. The mammalian (or mechanistic) target of rapamycin (mTOR) pathway has recently emerged as an important regulator regarding symmetry breaking. The mTOR pathway governs fundamental processes such as protein translation or metabolism. Its activity can be transduced by two complexes, which are called TORC1 and TORC2, respectively. So far, only TORC1 has been implicated with asymmetry development and appears to require very precise regulation. A number of recent papers provided evidence that dysregulated TORC1 results in alterations of motile cilia and asymmetry defects. In here, we give an update on what we know so far of mTORC1 in LR asymmetry development.
Institute for Biochemistry and Molecular Biology, Ulm University, Ulm, 89081, Germany.
Teresa
T
Casar Tena
Leibniz Institute for Age Research Fritz Lippmann Institute, Jena, 07745, Germany.
Martin D
MD
Burkhalter
Institute for Biochemistry and Molecular Biology, Ulm University, Ulm, 89081, Germany.
Melanie
M
Philipp
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002923:Cilia / Q000473:pathology*; D059446:Heterotaxy Syndrome / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes / Q000378:metabolism*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
D046912:Multiprotein Complexes; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases
Cilia; Heterotaxy; Left-right asymmetry; TORC1; Zebrafish