Tetradentate metal complexes derived from cephalexin and 2,6-diacetylpyridine bis(hydrazone): Synthesis, characterization and antibacterial activity.
Metal(II) coordination compounds of a hydrazone ligand (HL) derived from the condensation of cephalexin antibiotic with 2,6-diacetylpyridine bis(hydrazone) were synthesized. The hydrazone ligand and mononuclear [ML(H2O)2][PF6] (M(II)=Mn, Co, Ni, Zn) complexes were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and (1)H NMR spectral studies. The cephalexin 2,6-diacetylpyridine bis(hydrazone) ligand HL behaves as a monoanionic tetradentate NNNO chelating agent. The biological applications of complexes have been studied on two bacteria strains (Escherichia coli and Staphylococcus aureus) by agar diffusion disc method.
Department of Chemistry, Universidad de Oriente, Cumana 6101, Venezuela. Electronic address: juananacona@hotmail.com.
J R
JR
Anacona
Department of Chemistry, Universidad de Oriente, Cumana 6101, Venezuela.
Victor
V
Rangel
Department of Chemistry, Universidad de Oriente, Cumana 6101, Venezuela.
Marcos
M
Loroño
Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Valparaíso, Chile.
Juan
J
Camus
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002506:Cephalexin / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D006835:Hydrazones / Q000737:chemistry*; D008024:Ligands; D060328:Magnetic Phenomena; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013696:Temperature
D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D006835:Hydrazones; D008024:Ligands; D008670:Metals; D011725:Pyridines; D002506:Cephalexin
Antibacterial activity; Cephalexin 2,6-diacetylpyridine bis(hydrazone) ligand; Hydrazone metal complexes; Synthesis hydrazone containing cephalexin