Mitotic spindle orientation: semaphorin-plexin signaling flags the way.
The extracellular signals and corresponding receptors that align the mitotic spindle of symmetrically dividing cells within an epithelial sheet are largely unknown. In this issue of Developmental Cell, Xia et al. (2015) identify semaphorin-plexin signaling as a regulator of spindle orientation critical for kidney development and repair.
Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia; Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia; Department of Molecular Biology and Biochemistry, The University of Melbourne, Parkville, Victoria 3052, Australia. Electronic address: patrick.humbert@petermac.org.
Patrick O
PO
Humbert
Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria 3052, Australia.
Nathan J
NJ
Gödde
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009024:Morphogenesis / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D039961:Semaphorins / Q000378:metabolism*; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000378:metabolism*
D015815:Cell Adhesion Molecules; D009419:Nerve Tissue Proteins; D039961:Semaphorins