A Concise Synthesis of the Repeating Unit of Capsular Polysaccharide Staphylococcus aureus Type 8.
The first synthesis of the repeating unit of S. aureus capsular polysaccharide type 8 is described. The repeating unit is an unusual trisaccharide sequence of three uncommon sugars, all connected via 1,2-cis linkages. The synthetic trisaccharide was equipped with capping methyl groups at the points of propagation of the polysaccharide sequence.
†Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States.
Satsawat
S
Visansirikul
†Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States.
Jagodige P
JP
Yasomanee
†Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States.
Papapida
P
Pornsuriyasak
†Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States.
Medha N
MN
Kamat
†Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States.
Nikita M
NM
Podvalnyy
†Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States.
Chase P
CP
Gobble
Melissa
M
Thompson
Stephen A
SA
Kolodziej
†Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States.
Alexei V
AV
Demchenko
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D011135:Polysaccharides, Bacterial / Q000138:chemical synthesis* / Q000737:chemistry; D013211:Staphylococcus aureus / Q000737:chemistry*
D011135:Polysaccharides, Bacterial