[Rubella virus genetic determinant of attenuation].
Vaccination is the most effective and available way to prevent Rubella. Presently, 9 vaccine strains were registered. Nevertheless, the molecular mechanisms of the attenuation were poorly elucidated for the rubella virus. However, the study of these mechanisms identifying genotypic and phenotypic markers of attenuation, which together with sequence analysis could be used for the genetic stability control of vaccine strains, is still of current interest. Common trends of genetic changes in the process of adaptation to cold were found due to comparison of nucleic acid and amino acid sequences of the Russian strain C-77 with corresponding positions of the known rubella virus strains and its wild type progenitors, if available.
G V
GV
Dmitriev
T K
TK
Borisova
E B
EB
Faizuloev
R G
RG
Desiatskova
V V
VV
Zverev
D000222:Adaptation, Physiological; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D001483:Base Sequence; D002642:Chick Embryo; D002522:Chlorocebus aethiops; D003080:Cold Temperature; D004285:Dogs; D005814:Genes, Viral; D057809:HEK293 Cells; D006801:Humans; D061985:Madin Darby Canine Kidney Cells; D010802:Phylogeny; D012409:Rubella / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D012412:Rubella virus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D014611:Vaccination; D014613:Vaccines, Attenuated; D014709:Vero Cells; D014765:Viral Vaccines / Q000008:administration & dosage / Q000235:genetics* / Q000276:immunology; D014779:Virus Replication / Q000502:physiology
D014613:Vaccines, Attenuated; D014765:Viral Vaccines