Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population.
Histamine H2 receptor (HRH2) was previously suggested to affect the proliferation of breast cancer cells and disease-free survival of breast cancer patients. Furthermore, a common polymorphism, rs2067474, was identified in an enhancer element of the HRH2 gene promoter and was reported to be associated with various diseases including cancer. However, the relationship between this polymorphism and breast cancer risk and malignant degree remains unclear. The aim of this study was to clarify the clinical association of rs2067474 polymorphism with breast cancer. A total of 201 unrelated Chinese Han breast cancer patients and 238 ethnicity-matched health controls were recruited and rs2067474 polymorphism was genotyped. Logistic regression analyses were performed to calculate the odds ratios (ORs) as a measure of association of genotype with breast cancer according to 3 genetic models (dominant, recessive, and additive). Although the percentage of hormone receptor negative cases tended to be higher in AA genotypes, we did not find any significant associations of rs2067474 polymorphism with breast cancer risk or with related clinicopathological parameters in the present study, which indicates that rs2067474 polymorphism of HRH2 gene might not be a risk factor in the development of breast cancer in Chinese Han population.
Department of Cardio-Thoracic Surgery, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China ; Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China.
Wen-Ke
WK
Cai
Hepatobiliary Surgery Center, 302 Hospital, Beijing 100039, China.
Jia-Bin
JB
Zhang
Department of Pharmacy, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
Niu-Min
NM
Wang
Department of Anesthesiology, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou 570208, China.
Ying-Lin
YL
Wang
Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China.
Can-Hu
CH
Zhao
Department of Pharmacy, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China.
Jun
0000-0002-2237-8771
J
Lu
Department of Pharmacy, Kunming General Hospital of Chengdu Military Region, Kunming 650032, China.
Gong-Hao
GH
He
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011970:Receptors, Histamine H2 / Q000235:genetics*; D012307:Risk Factors
D014408:Biomarkers, Tumor; D011970:Receptors, Histamine H2