A Novel Anxiety and Affective Spectrum Disorder of Mind and Body-The ALPIM (Anxiety-Laxity-Pain-Immune-Mood) Syndrome: A Preliminary Report.
The authors describe a spectrum disorder comprising a core anxiety (A) disorder and four domains: joint laxity (L), chronic pain syndromes (P), immune disorders (I), and mood disorders (M)-dubbed the ALPIM syndrome. This study examined 76 consecutive outpatients with an anxiety disorder plus at least one somatic condition from three domains. More than 80% of the patients had panic attacks, fibromyalgia, and major depressive episodes. Associations were found between joint laxity and bipolar III, headache with bipolar II, and bipolar II with chronic fatigue syndrome. Significant relationships were demonstrated within and between domains, validating ALPIM as a syndrome.
From the Division of Neuropsychopharmacology, Dept. of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, NY (JC, SG); the Dept. of Psychiatry, Winthrop University Hospital, Mineola, NY (DS); the Michael E. Debakey VA Medical Center, Houston, TX (SJM); the Menninger Dept. of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX (SJM); and the Institut de Neuropsiquiatria i Addiccions, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain (AB).
Jeremy
J
Coplan
Deepan
D
Singh
Srinath
S
Gopinath
Sanjay J
SJ
Mathew
Antonio
A
Bulbena
D000328:Adult; D000342:Affective Symptoms / Q000150:complications* / Q000175:diagnosis; D000368:Aged; D001007:Anxiety / Q000150:complications* / Q000175:diagnosis; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000150:complications* / Q000175:diagnosis; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000150:complications* / Q000175:diagnosis; D011795:Surveys and Questionnaires; D055815:Young Adult