Solubility of chiral species as function of the enantiomeric excess.
The solubility of racemizable and nonracemizable chiral species is discussed in terms of: enantiomeric excess, nature of solvent and the solid phases, which are in equilibrium with a saturated solution. Stable and metastable equilibria are contemplated by an extensive used of phase diagrams.
Normandie Université, Crystal Genesis Unit SMS EA3233 IMR 4114, 1 Rue Tresniere Université de Rouen, Mont Saint Aignan CEDEX, France.
Gerard
G
Coquerel
D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D012996:Solutions / Q000737:chemistry*; D012997:Solvents; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations; D012996:Solutions; D012997:Solvents
phase diagrams; solubility vs enantiomeric excess