Values of iodine metabolism biomarkers in assessing the iodine nutrition status in surgically treated patients with thyroid disease.
OBJECTIVE
To assess the clinical application value of iodine metabolism biomarkers in assessing iodine nutrition status in surgically treated patients with thyroid disease.


METHODS
Blood,morning urine and 24-hour urine samples were collected in 31 healthy volunteers and in 30 surgically treated patients with thyroid disease before and after surgery. Iodine concentration was analyzed by inductively coupled plasma mass spectrometry. The iodine metabolism biomarkers including serum iodine (SI), morning urine iodine(UI), morning urine iodine/urine creatinine ratio (UI/UCr), 24-hour urine iodine (24 h UI), and 24-hour urine iodine excretion (24 h UIE) were evaluated in these two groups. In addition, the validation coincidence rate of iodine metabolism biomarkers in healthy volunteers to different reference ranges including World Health Organization, Mayo Clinic, and Quest Diagnostics were calculated.


RESULTS
The UI/UCr ratio of pre-operative thyroid disease patients was significantly lower than that of healthy volunteers (P<0.05), while the other biomarkers showed no significant differences (all P>0.05) between these two groups. The SI, UI ,and 24 h UI in postoperative thyroid disease patients were significantly higher than those of the pre-operative patients (all P<0.05). Though the medians of all biomarkers in healthy volunteers were within the reference ranges,only the validation coincidence rates of SI, UI, and UI/UCr in the 41-70-year populations were over than 90% according to Mayo Clinic; furthermore, the area under the receiver operating characteristic curve about UI/UCr ratio (0.737) was the biggest within the iodine metabolism biomarkers.


CONCLUSIONS
The UI/UCr ratio may be used for iodine nutrition evaluation in surgically treated patients with thyroid disease.
Department of Clinical Laboratory, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Jian-hua
JH
Han
Department of General Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Lian
L
Wu
Department of Clinical Laboratory, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Song-lin
SL
Yu
Department of Clinical Laboratory, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Hui-ling
HL
Fang
Department of General Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Wei-ming
WM
Kamg
Department of Clinical Laboratory, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Xin-qi
XQ
Cheng
Department of Clinical Laboratory, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Jie
J
Lu
Department of General Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Jian-chun
JC
Yu
Department of Clinical Laboratory, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Ling
L
Qiu
D015415:Biomarkers; D003404:Creatinine; D006801:Humans; D007454:Iodides; D007455:Iodine; D015596:Nutrition Assessment; D009752:Nutritional Status; D012016:Reference Values; D013959:Thyroid Diseases
D015415:Biomarkers; D007454:Iodides; D007455:Iodine; D003404:Creatinine