Effect of hypobaric hypoxia on cognitive functions and potential therapeutic agents.
High altitude (HA), defined as approximately 3000-5000 m, considerably alters physiological and psychological parameters within a few hours. Chronic HA-mediated hypoxia (5000 m) results in permanent neuronal damage to the human brain that persists for one year or longer, even after returning to sea level. At HA, there is a decrease in barometric pressure and a consequential reduction in the partial pressure of oxygen (PO2), an extreme environmental condition to which humans are occasionally exposed. This condition is referred to as hypobaric hypoxia (HBH), which represents the most unfavourable characteristics of HA. HBH causes the disruption of oxygen availability to tissue. However, no review article has explored the impact of HBH on cognitive functions or the potential therapeutic agents for HBH. Therefore, the present review aimed to describe the impact of HBH on both physiological and cognitive functions, specifically learning and memory. Finally, the potential therapeutic agents for the treatment of HBH-induced cognitive impairment are discussed.
Laboratory of Neuropsychopharmacology, FFCLRP, Universidade de São Paulo, Campus USP, Ribeirão Preto, SP 14049-901, Brazil; Instituto de Neurociencias e Comportamento, Avenida do Café, 2450, Ribeirão Preto, SP 14050-000, Brazil.
Sangu
S
Muthuraju
Departments of Pediatrics-Neurology and Neuroscience, Program in Developmental Biology, Program in Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, 1250 Moursund Street, Room 1250, Houston, TX 77030, USA.
Soumya
S
Pati
high altitude; hypoxia; therapeutics