Acute colonic pseudo-obstruction in a child taking trihexyphenidyl for drooling: Prescribers beware.
Colonic pseudo-obstruction (Ogilvie's Syndrome) in children is relatively uncommon. We report an unusual case of colonic pseudo-obstruction in an 8-year-old child with cerebral palsy and long-term hypomotility issues being treated for drooling with the anticholinergic medication trihexyphenidyl. He presented as an emergency with severe abdominal distension, abdominal tenderness and vomiting. An emergency laparotomy revealed colonic dilatation and a defunctioning ileostomy was created. To our knowledge, this is the first case reporting colonic pseudo-obstruction as a possible complication of treatment with trihexyphenidyl. We suggest prescribers should exercise caution when prescribing trihexyphenidyl in patients with long-term intestinal hypomotility issues.
Department of Paediatric Otolaryngology, Yorkhill Children's Hospital, Glasgow, United Kingdom. Electronic address: finnbegbie@doctors.org.uk.
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F
Begbie
Department of Paediatric Surgery, Yorkhill Children's Hospital, Glasgow, United Kingdom.
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G
Walker
Department of Paediatric Otolaryngology, Yorkhill Children's Hospital, Glasgow, United Kingdom.
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Kubba
Department of Paediatric Surgery, Yorkhill Children's Hospital, Glasgow, United Kingdom.
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Sabharwal
D002547:Cerebral Palsy / Q000150:complications; D002648:Child; D003112:Colonic Pseudo-Obstruction / Q000139:chemically induced*; D006801:Humans; D008297:Male; D018727:Muscarinic Antagonists / Q000009:adverse effects*; D012798:Sialorrhea / Q000188:drug therapy / Q000209:etiology; D014282:Trihexyphenidyl / Q000009:adverse effects*
D018727:Muscarinic Antagonists; D014282:Trihexyphenidyl
Drooling; Hypomotility; Pseudo-obstruction; Trihexyphenidyl