[Anti-hyperuricemia effect and mechanism of polydatin in mice].
Hyperuricemia mice model was established with uricase inhibitor (potassium oxonate) and uric acids in serum were observed. Polydatin (5, 10, 20 mg · kg(-1)) and benzbromarone (16.7 mg · kg(-1)) were given ig for 7 d in mice. Kidney tissues were used to detect gene contents ofurate anion transporter 1 (URAT1), organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) by real-time-PCR. The results showed that polydatin and benzbromarone can significantly reduce uric acid in blood of hyperuricemia mice (P < 0.05), compared with the model group. URAT1, OAT1 and OAT3 contents of the kidney in hyperuricemia mice changed significantly (P < 0.05), compared with the blank group. Polydatin can significantly inhibit the changing trends in these genes induced by potassium oxonate in a dose-dependent manner, the difference was significant (P < 0.05), compared with the model group. Those indicated that polysatin could reduce the level of the serum uric acid through promoting uric acid excretion.
Gao
G
Wu
Han-Bin
HB
Wu
Hong
H
Jiang
D000818:Animals; D004195:Disease Models, Animal; D005960:Glucosides / Q000494:pharmacology*; D033461:Hyperuricemia / Q000188:drug therapy*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D013267:Stilbenes / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood
D005960:Glucosides; D013267:Stilbenes; D014527:Uric Acid; C058229:polydatin