Xanthone derivatives from the fermentation products of an endophytic fungus Phomopsis sp.
Three new xanthones, 1-hydroxy-3-hydroxyethyl-5-methoxy-6-methoxycarbonylxanthone (1), 1,4-dihydroxy-3-hydroxyethyl-5-methoxy-6-methoxycarbonylxanthone (2), and 1-hydroxy-3-hydroxyethyl-4-methoxy-8-methoxycarbonylxanthone (3), together with five known xanthones (4-8) were isolated from the fermentation products of an endophytic fungus Phomopsis sp.. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR spectroscopic techniques. Compounds 1-3 and 7 were also tested for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) by the MTT method, with paclitaxel used as the positive control. Compound 1 showed cytotoxicity against A549 and PC3 cells with IC50 values of 3.2 and 2.5 μM, respectively, 2 showed potential cytotoxicity against NB4 cells, with an IC50 value of 3.6 μM, and 3 showed cytotoxicity against A549 cells with an IC50 value of 3.5 μM.
Yanlin
Y
Meng
Yuchun
Y
Yang
Ying
Y
Qin
Congfang
C
Xia
Min
M
Zhou
Xuemei
X
Gao
Gang
G
Du
Qiufen
Q
Hu
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D045744:Cell Line, Tumor; D005285:Fermentation / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D044004:Xanthones / Q000737:chemistry* / Q000378:metabolism
D000970:Antineoplastic Agents; D044004:Xanthones