Ethnic differences in acylation stimulating protein (ASP) in Xinjiang Uygur autonomous region, China.
BACKGROUND
Acylation Stimulating Protein (ASP) stimulates adipocyte triglyceride synthesis and glucose transport. The aim was to examine ethnic difference in ASP and the relation to lipid profile and other parameters among Han, Uygur, and Kazak healthy populations matched for BMI, age and gender distribution.


METHODS
331 healthy persons were recruited in total (age 30-60 yr): 137 Han, 114 Uygur, and 80 Kazak. Anthropometric measurements including height, weight, waist circumference, hip circumference, blood pressure, ankle brachial index (ABI), and pulse wave velocity (PWV) were measured in all participants. Fasting concentrations of fasting glucose, uric acid, and lipids, including triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), ASP, complement C3, insulin, non-esterified fatty acid (NEFA) and C-reactive protein (CRP) were measured.


RESULTS
ASP in Uygurs was significantly lower than Han subjects (P=0.0003). The Uygurs demonstrated the highest C3 (P<0.001), CRP (P=0.001), and NEFA concentrations (P=0.008), the lowest %ASP/C3 (P<0.001) and TC levels (P=0.0008) vs those in Han and Kazak populations. In the Han group, glucose, the average ABI (an index of peripheral response) and diastolic blood pressure were significantly different from both Uygur and Kazak group (P=0.0007, P=0.0003, P=0.0001) while Kazaks show the lowest waist/hip circumference (WHR) (P=0.0003).


CONCLUSIONS
There are ethnic differences in ASP, C3, CRP and lipid profiles in healthy Han, Uygur, and Kazak populations. Overall, the Uygur populations presents with a disadvantageous metabolic profile as compared to Han and Kazak groups.
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, People's Republic of China.
Ying
Y
Gao
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, People's Republic of China.
Xiang
X
Xie
Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ), Laval University Québec, Québec, Canada.
Katherine
K
Cianflone
Centre de Recherche Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ), Laval University Québec, Québec, Canada.
Marc
M
Lapointe
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, People's Republic of China.
Jie
J
Guan
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, People's Republic of China.
Gao Wa Bai
GW
Bu-Jiaer
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, People's Republic of China.
Dan
D
Chen
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, People's Republic of China.
Wei-Yun
WY
Zhao
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University Urumqi 830011, People's Republic of China.
Yi-Tong
YT
Ma
Acylation stimulating protein (ASP); C3; ethnicity