[Mucosal immune response to Helicobacter pylori in children with gastroduodenal diseases and allergy].
In children with chronic gastritis/gastroduodenitis, erosions and ulcer of stomach and duodenum and associated allergic diseases (asthma, allergic rhinitis, atopic dermatitis) CagA, sIgA and IgE antibodies to the H. pylori were determined by ELISA in the supernatants of feces. H. pylori infection was determined according to "Maastricht IV". The frequency and contents of CagA did not differ among the groups we studied. However, in children with positive urease test the contents of CagA was significantly higher (p = 0.03) compared with other children. The highest levels of sIgA were found in the feces supernatants from non-allergic children with CG/CGD and were associated with H. pylori infection. The immune response in children with erosions and ulcer of stomach and duodenum and in children with allergy was presented the sIgE to H. pylori. Also, the negative correlation between the level sIgE to H. pylori and content sIgA was found in children with allergy. Thus, increased IgE indicates not only allergy, but also acts as a protective role in the development of anti-infective immunity.
S A
SA
Mazurina
N V
NV
Ilintseva
V B
VB
Gervazieva
D000293:Adolescent; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D001944:Breath Tests; D002648:Child; D004382:Duodenitis / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D005753:Gastric Mucosa / Q000276:immunology; D005756:Gastritis / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007413:Intestinal Mucosa / Q000276:immunology; D012808:Sigma Factor / Q000276:immunology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D012808:Sigma Factor; C080866:cagA protein, Helicobacter pylori; C111259:sigE protein, Bacteria