Measuring the hepatic venous pressure gradient in the upper digestive hemorrhages.
The upper digestive hemorrhage is one of the main causes of mortality from liver cirrhosis (CH). The measurement of the hepatic venous pressure gradient (HVPG) by angiographic way can be used for the determination of the risk of hemorrhage. The aim of this study is to verify the influence of the HVPG measurement upon the survival in patients with CH and upper digestive hemorrhage. A retrospective pilot study on 33 patients with upper digestive hemorrhage divided into two groups according to the therapeutic attitude followed, was carried out. One group was classically treated, with variceal band ligation, non-elective beta-blockers and in emergency Octreotide. The other group was treated depending on the value of HVPG. From the moment of the first episode of digestive hemorrhage, the survival period was in average of 8.1 months for the patients with viral etiology and for those with alcoholic etiology it was of 19.7 months. In patients treated after HVPG measurement, the average survival period was of 34.2 months and in patients "classically" treated, the average survival period was of 15.5 months (significant difference). In conclusion, the measurement of HVPG allowed the selection of a high-risk group of patients. This permitted the making of a therapeutical decision with a significant prolongation of life in these patients.
"Carol Davila" University of Medicine and Pharmacy, Bucharest; Department of Gastroenterology, "Sf. Ioan" Hospital, Bucharest, Romania.
S
S
Omer
Department of Cardiology, "Sf. Ioan" Hospital, Bucharest, Romania.
O
O
Zara
Department of Biophysics, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
A
A
Iftime
"Carol Davila" University of Medicine and Pharmacy, Bucharest; Department of Gastroenterology, "Sf. Ioan" Hospital, Bucharest, Romania.
I
I
Dina
D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000401:mortality / Q000503:physiopathology / Q000628:therapy; D008297:Male; D010865:Pilot Projects; D017082:Portal Pressure; D012189:Retrospective Studies
Hepatic venous pressure gradient; liver cirrhosis; upper digestive hemorrhage