DNA and RNA derivatives to optimize distribution and delivery.
Synthetic, complementary DNA single strands and short interfering RNA double strands have been found to inhibit the expression of animal, plant, and viral genes in cells, animals, and patients, in a dose dependent and sequence specific manner. DNAs and RNAs, however, are readily digested in biological systems. Hence, chemists are obliged to design and synthesize nuclease-resistant analogs of normal DNA (Fig. 1).
Laboratory of Molecular Design, Thomas Jefferson University, Bluemle Life Sciences Building 219, 233 S. 10th Street, Philadelphia, PA 19107-5541, USA. Electronic address: eric@wickstromlab.org.
Eric
E
Wickstrom
D000818:Animals; D016373:DNA, Antisense / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D015316:Genetic Therapy; D006801:Humans; D034622:RNA Interference / Q000187:drug effects; D016372:RNA, Antisense / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology
D016373:DNA, Antisense; D016372:RNA, Antisense