Denosumab, a Potential Alternative to the Surgical Treatment of Distal Radius Giant Cell Tumor of Bone: Case Report.
Juxta-articular giant cell tumors can pose major surgical challenges. Aggressive distal radius giant cell tumors often require complex reconstructive procedures that are associated with numerous complications. We present a case of a 25-year old man with a Campanacci grade 3 giant cell tumor of the distal radius that was successfully treated with denosumab without complex reconstructive procedures. At 3.5-year follow-up and 1-year drug free period, the patient remained asymptomatic without histologic evidence of recurrent tumor. With denosumab therapy, patients can potentially avoid surgery and achieve a successful outcome.
Southern California Permanente Medical Group, Antelope Valley Medical Offices, Lancaster, CA. Electronic address: mjpark@alumni.brown.edu.
Min Jung
MJ
Park
Division of Medical Oncology, Stanford Hospitals and Clinics, Stanford, CA.
Kristen N
KN
Ganjoo
Robert A Chase Hand and Upper Limb Center, Stanford Hospitals and Clinics, Redwood City, CA.
Amy L
AL
Ladd
D000328:Adult; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000069448:Denosumab / Q000627:therapeutic use*; D018212:Giant Cell Tumor of Bone / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D011884:Radius
D050071:Bone Density Conservation Agents; D000069448:Denosumab
Denosumab; distal radius; giant cell tumor