[The use of semi-synthetic polymers in the formulation of sucking and chewable tablets containing sage extract and zinc gluconate].
BACKGROUND
Halitosis and gingivitis are most common pathologies (15-60% of population) which, if left untreated, lead to periodontal diseases and tooth loss.


OBJECTIVE
The aim of this study was to develop, based on polymers of dry sage extract and zinc gluconate, tablets intended for sucking and chewing that can be applied in the treatment of halitosis and gingivitis.


METHODS
Dried aqueous sage extract, zinc gluconate, Pharmagum M, Prosolv SMCC90 and SMCCHD90, Vivapur 102, sorbitol, mannitol, ludipress. Direct tableting. Testing pharmacopeial parameters and pharmaceutical availability (using basket and rotating disk methods) of tablets intended for sucking and chewing. Approximation of the obtained results.


RESULTS
Grey and green color tablets were obtained with smooth and uniform surface, without stains, spalls or mechanical damage. The determined average mass (weight) of a tablet complied with the standard. The friability and crushing strength test revealed that tablets containing Prosolv SMCCHD90, Vivapur 102 and mannitol demonstrated the highest mechanical strength. Tablets containing these substances and intended for sucking had prolonged disintegration and release time. Tablets intended for chewing had a hardness at the level of 124 N.They demonstrated compressibility, low friability and prolonged release. The release profiles of tablets intended for sucking (v2) and those for chewing, obtained by basket and rotating disk methods, were similar.


CONCLUSIONS
The addition of Prosolv SMCCHD90, Vivapur 102 and mannitol increased significantly the mechanical strength (higher hardness, lower friability), prolonged the disintegration time and slowed the release from the obtained tablets intended for sucking and chewing. The application of Prosolv SMCCHD90 in the formulation of tablets for chewing carries the risk for sorption of active components to the polymer structure. This process takes place in the early stage of the release. Rotating disk method used in pharmaceutical availability testing gives better results while analyzing the phenomenon than the standard basket method. The suggested and tested formulations of tablets intended for sucking and chewing may be used as an alternative to formulations containing dried titrated extracts from plants of antimicrobial activity (sage - Salvia officinalis) in combination with substances binding volatile sulfur compounds (zinc gluconate).
Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
Wojciech Andrzej
WA
Linka
Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
Ewa
E
Golenia
Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
Marian Mikołaj
MM
Zgoda
Zakład Technologii Postaci Leku, Uniwersytet Medyczny w Łodzi, Łódź, Polska.
Michał Krzysztof
MK
Kołodziejczyk
D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D005079:Excipients / Q000737:chemistry; D005942:Gluconates / Q000008:administration & dosage / Q000737:chemistry*; D006244:Hardness; D008409:Mastication; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D027543:Salvia officinalis / Q000737:chemistry*; D012995:Solubility; D013391:Sucking Behavior; D013607:Tablets / Q000737:chemistry*; D013678:Technology, Pharmaceutical
D000890:Anti-Infective Agents; D005079:Excipients; D005942:Gluconates; D010936:Plant Extracts; D011108:Polymers; D013607:Tablets; C477445:vivapur; D002482:Cellulose; C030691:gluconic acid