Bone geometry of the hip is associated with obesity and early structural damage--a 3.0 T magnetic resonance imaging study of community-based adults.
BACKGROUND
The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abnormalities, such as cartilage defects and bone marrow lesions.


METHODS
One hundred and forty one older adults with no diagnosed hip osteoarthritis had weight and body mass index measured between 1990 and 1994 and again in 2009 to 2010. Acetabular depth and lateral centre edge angle, both measures of acetabular over-coverage, as well as femoral head cartilage volume, cartilage defects and bone marrow lesions were assessed with 3.0 T magnetic resonance imaging performed in 2009 to 2010.


RESULTS
Current body mass index, weight and weight gain were associated with increased acetabular depth and lateral centre edge angle (all P ≤ 0.01). For every 1 mm increase in acetabular depth, femoral head cartilage volume reduced by 59 mm(3) (95% confidence interval (CI) 20 mm(3) to 98 mm(3), P < 0.01). Greater acetabular depth was associated with an increased risk of cartilage defects (odds ratio (OR) 1.22, 95% CI 1.03 to 1.44, P = 0.02) and bone marrow lesions (OR 1.29, 95% CI 1.01 to 1.64, P = 0.04) in the central region of the femoral head. Lateral centre edge angle was not associated with hip structure.


CONCLUSIONS
Obesity is associated with acetabular over-coverage. Increased acetabular depth, but not the lateral centre edge angle, is associated with reduced femoral head cartilage volume and an increased risk of cartilage defects and bone marrow lesions. Minimising any deepening of the acetabulum (for example, through weight management) might help to reduce the incidence of hip osteoarthritis.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.|Baker IDI Heart and Diabetes Institute, Commercial Road, Melbourne, VIC, 3004, Australia. andrew.teichtahl@monash.edu.
Andrew J
AJ
Teichtahl
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. yuanyuan.wang@monash.edu.
Yuanyuan
Y
Wang
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. sesmi8@student.monash.edu.
Sam
S
Smith
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. anita.wluka@monash.edu.
Anita E
AE
Wluka
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. zlzhu1@student.monash.edu.
Michael
M
Zhu
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. donna.urquhart@monash.edu.
Donna
D
Urquhart
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. graham.giles@cancervic.org.au.|Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, 3053, Australia. graham.giles@cancervic.org.au.|Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, VIC, 3004, Australia. graham.giles@cancervic.org.au.
Graham G
GG
Giles
MRI Department, Healthcare Imaging Services, Epworth Hospital, Richmond, VIC, 3121, Australia. richard.o'sullivan@healthcareimaging.com.au.|Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia. richard.o'sullivan@healthcareimaging.com.au.
Richard
R
O'Sullivan
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia. flavia.cicuttini@monash.edu.
Flavia M
FM
Cicuttini
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D006621:Hip Joint / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012111:Residence Characteristics