STEC:O111-HUS complicated by acute encephalopathy in a young girl was successfully treated with a set of hemodiafiltration, steroid pulse, and soluble thrombomodulin under plasma exchange.
We report a 14-year-old girl, who developed shigatoxin-producing E. coli (STEC)-HUS complicated by encephalopathy. She was successfully treated with hemodiafiltration, high-dose methylprednisolone pulse therapy, and soluble recombinant thrombomodulin under plasma exchange. von Willebrand factor multimers analysis provides potential insights into how the administered therapies might facilitate successful treatment of STEC-HUS.
Department of Emergency and Critical Care Medicine, Yodogawa Christian Hospital Osaka, Japan.
Noritaka
N
Yada
Department of Emergency and Critical Care Medicine, Nara Medical University Kashihara, Japan.
Masayuki
M
Fujioka
South Carolina Center of Economic Excellence for Medication Safety and Efficacy, the Southern Network on Adverse Reactions (SONAR), the South Carolina College of Pharmacy, the WJB Dorn Veterans Administration Hospital Columbia, South Carolina.
Charles L
CL
Bennett
Department of Gastroenterology, Yodogawa Christian Hospital Osaka, Japan.
Kazuya
K
Inoki
Department of Emergency and Critical Care Medicine, Yodogawa Christian Hospital Osaka, Japan.
Toyokazu
T
Miki
Department of Gastroenterology, Yodogawa Christian Hospital Osaka, Japan.
Akihiko
A
Watanabe
Department of Nephrology, Yodogawa Christian Hospital Osaka, Japan.
Toshiko
T
Yoshida
Department of Blood Transfusion Medicine, Nara Medical University Kashihara, Japan.
Masaki
M
Hayakawa
Department of Blood Transfusion Medicine, Nara Medical University Kashihara, Japan.
Masanori
M
Matsumoto
Department of Blood Transfusion Medicine, Nara Medical University Kashihara, Japan.
Yoshihiro
Y
Fujimura
Encephalopathy; Escherichia coli O111; hemolytic uremic syndrome; plasma exchange; recombinant soluble thrombomodulin; von Willebrand factor