The first Malay database toward the ethnic-specific target molecular variation.
BACKGROUND
The Malaysian Node of the Human Variome Project (MyHVP) is one of the eighteen official Human Variome Project (HVP) country-specific nodes. Since its inception in 9(th) October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project. MyHVP also act as the center of coordination for genotypic and phenotypic variation studies of the Malaysian population. A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups. This ethnic-specific database is called the Malaysian Node of the Human Variome Project database (MyHVPDb).


RESULTS
Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays. In the near future, it will expand for the other Malaysian ethnics as well. The data sets are specified based on diseases or genetic mutation types which have three main subcategories: Single Nucleotide Polymorphism (SNP), Copy Number Variation (CNV) followed by the mutations which code for the common diseases among Malaysians. MyHVPDb has been open to the local researchers, academicians and students through the registration at the portal of MyHVP ( http://hvpmalaysia.kk.usm.my/mhgvc/index.php?id=register ).


CONCLUSIONS
This database would be useful for clinicians and researchers who are interested in doing a study on genomics population and genetic diseases in order to obtain up-to-date and accurate information regarding the population-specific variations and also useful for those in countries with similar ethnic background.
Department of Pediatric, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. halimfikri@gmail.com.|Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu, Malaysia. halimfikri@gmail.com.
Hashim
H
Halim-Fikri
Department of Pediatric, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. ali_etemad_c@yahoo.com.
Ali
A
Etemad
Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu, Malaysia. azubaidi@unisza.edu.my.
Ahmad Zubaidi
AZ
Abdul Latif
Centre of Research for Computational Sciences and Informatics in Biology, Bioindustry, Environment, Agriculture & Healthcare, University of Malaya, 50603, Kuala Lumpur, Malaysia. merican@um.edu.my.|Institute of Biological Sciences, University of Malaya, 50603, Kuala Lumpur, Malaysia. merican@um.edu.my.
Amir Feisal
AF
Merican
Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu, Malaysia. atifameen@gmail.com.|Molecular Medicine Cluster, Biomedical Center, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu, Malaysia. atifameen@gmail.com.
Atif Amin
AA
Baig
Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. azlina_aa@um.edu.my.
Azlina Ahmad
AA
Annuar
School of Biosciences and Biotechnology, National University of Malaysia, 43600, Bangi, Selangor, Malaysia. eismail@ukm.edu.my.
Endom
E
Ismail
Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. isalahshouri@gmail.com.
Iman
I
Salahshourifar
Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. liza@usm.my.
Ahmad Tajudin
AT
Liza-Sharmini
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. marini@usm.my.
Marini
M
Ramli
Molecular Medicine Cluster, Biomedical Center, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Terengganu, Malaysia. miwanshah@gmail.com.
Mohamed Irwan
MI
Shah
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. faridjohan@usm.my.
Muhammad Farid
MF
Johan
School of Health Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia. nnorliza@usm.my.
Nik Norliza Nik
NN
Hassan
Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. noisha@ummc.edu.my.
Noraishah Mydin
NM
Abdul-Aziz
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. drhaslina@kb.usm.my.
Noor Haslina
NH
Mohd Noor
Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. shak2_03@yahoo.com.
Ab Rajab
AR
Nur-Shafawati
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. roslin@usm.my.
Rosline
R
Hassan
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. rosnahkb@usm.my.
Rosnah
R
Bahar
Oral Cancer Research Coordinating Centre, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. rosnahbz12@gmail.com.
Rosnah Binti
RB
Zain
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. shafini@usm.my.
Shafini Mohamed
SM
Yusoff
Department of Pediatric, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. surini@usm.my.
Surini
S
Yusoff
Faculty of Biotechnology & Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. sgtan@upm.edu.my.
Soon Guan
SG
Tan
Department of Pediatrics, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. thongmk@um.edu.my.
Meow-Keong
MK
Thong
Human Genome Center, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. hatinwanisa@yahoo.co.uk.
Hatin
H
Wan-Isa
Department of Hematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. wzaidah@usm.my.
Wan Zaidah
WZ
Abdullah
Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. zahurin@um.edu.my.
Zahurin
Z
Mohamed
Department of Pediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia. zarinaal@ppukm.ukm.edu.my.
Zarina
Z
Abdul Latiff
Department of Pediatric, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. zilfalil2@hotmail.com.
Bin Alwi
BA
Zilfalil
D030541:Databases, Genetic; D005006:Ethnicity / Q000235:genetics*; D006801:Humans; D008296:Malaysia