Correlation of Increased Expression of MicroRNA-155 in Bladder Cancer and Prognosis.
OBJECTIVE
To investigate the expression level and clinical significance of microRNA-155 (miR-155) in bladder cancer.


METHODS
We collected 102 pairs of tissue specimens from patients with primary bladder cancer and adjacent normal bladder specimens between March 2008 and May 2013. Quantitative real-time polymerase chain reaction (QRT-PCR) was performed to detect the expression levels of miR-155. We performed univariate survival analyses using the Kaplan-Meier method and assessed statistical significance between survival curves via the log-rank test.


RESULTS
The mean (SD) level of miR-155 expression in tissues with bladder cancer was 13.78 (4.80), which was significantly higher on average than that in adjacent normal bladder tissues (6.14 [2.26], P <.001). Progression-free survival (PFS) was significantly lower for patients with bladder cancer who had a high expression level of miR-155 (5-year survival rate, 23.0%) than those with a low miR-155 expression level (5-year survival rate, 48.9%; P <.001).


CONCLUSIONS
We found that elevated expression of miR-155 is correlated with a poor outcome for patients with bladder cancer; this suggests that miR-155 is a potential biomarker for bladder cancer prognosis.
Department of Urology, Yantai Yuhuangding Hospital, Yantai, Shandong, China.
Hui
H
Wang
Department of Urology, Yantai Yuhuangding Hospital, Yantai, Shandong, China dr_menchangping@126.com.
Chang-Ping
CP
Men
D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013223:Statistics as Topic; D001743:Urinary Bladder / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism / Q000473:pathology*
C524942:MIRN155 microRNA, human; D035683:MicroRNAs
biomarker; bladder cancer; microRNA-155; prognostic factor; quantitative real-time PCR; survival