Icosandrin, a novel peltogynoid from the fruits of Phytolacca icosandra (Phytolaccaceae).
Besides the known compounds ( ± ) 3,3-bis-demethylpinoresinol (2), americanol A (3), spergulagenic acid (4), epi-acetylaleuritolic acid (5), 6'-palmityl-α-spinateryl-d-glucoside (6a) and 6'-palmityl-δ(7)-stigmastenyl-d-glucoside (6b), a novel peltogynoid (1) named icosandrin was obtained from the dried fruits of Phytolacca icosandra. This new compound was characterised by 1D-/2D-NMR, UV, IR and HR-MS techniques as 11ξ-methoxy-6,7-methylenedioxy-[2]benzopyrano-[4,3-b][1]-benzopyran-4-one. Toxicity of 1 was assessed through the Brine Shrimp Lethality Assay. Lignan 2 is reported for the first time in Phytolaccaceae family.
a Departamento de Química, Edificio de Química y Procesos , Universidad Simón Bolívar (USB) , Apartado 89000, Caracas 1080A , Venezuela.
Elier
E
Galarraga Montes
b Laboratorio de Productos Naturales, Departamento de Química, Facultad de Ciencias , Universidad de Los Andes (ULA) , Mérida 5101 , Venezuela.
Juan Manuel
JM
Amaro-Luis
D000818:Animals; D001156:Artemia; D001578:Benzopyrans; D002867:Chromones / Q000737:chemistry*; D002965:Classification; D005638:Fruit / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D029603:Phytolacca / Q000737:chemistry / Q000145:classification; D029602:Phytolaccaceae; D010936:Plant Extracts / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes
D001578:Benzopyrans; D002867:Chromones; D006576:Heterocyclic Compounds, 4 or More Rings; D010936:Plant Extracts; D014315:Triterpenes; C575677:benzopyran-4-one; C014947:acetylaleuritolic acid
BSLA; Phytolacca icosandra; Phytolaccaceae; lignans; peltogynoids