Differential expression of CD57 in antigen-reactive CD4+ T cells between active and latent tuberculosis infection.
The development of diagnostic tests that predict the progression of latent tuberculosis infection to active disease is pivotal for the eradication of tuberculosis. As an initial step to achieve this goal, our study's aim was to identify biomarkers that differentiate active from latent tuberculosis infection. We compared active and latent tuberculosis infection groups in terms of the precursor frequency, functional subset differentiation, and senescence/exhaustion surface marker expression of antigen-specific CD4(+) T cells, which were defined as dividing cells upon their encountering with Mycobacterium (M.) tuberculosis antigens. Among several parameters shown to have statistically significant differences between the two groups, the frequency of CD57-expressing cells could differentiate effectively between active disease and latent infection. Our results suggest that the expression of CD57 in M. tuberculosis-reactive CD4(+) T cells could be a promising candidate biomarker with which to identify individuals with latent tuberculosis infection prone to progression to active disease.
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul 100-799, South Korea.
Ji Yeon
JY
Lee
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul 100-799, South Korea.
Ina
I
Jeong
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul 100-799, South Korea.
Joon-Sung
JS
Joh
Jung-gu Community Health Center, Seoul 132-713, South Korea.
Young Won
YW
Jung
Center for Chronic Diseases, Research Institute, National Medical Center, Seoul 100-799, South Korea.
Soo Yeon
SY
Sim
Center for Chronic Diseases, Research Institute, National Medical Center, Seoul 100-799, South Korea.
Boram
B
Choi
Center for Chronic Diseases, Research Institute, National Medical Center, Seoul 100-799, South Korea.
Hyeon-Gun
HG
Jee
Center for Chronic Diseases, Research Institute, National Medical Center, Seoul 100-799, South Korea. Electronic address: dglim@nmc.or.kr.
Dong-Gyun
DG
Lim
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D018959:CD57 Antigens / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D055985:Latent Tuberculosis / Q000175:diagnosis / Q000378:metabolism*; D007963:Leukocytes, Mononuclear; D008297:Male; D008875:Middle Aged; D061026:Programmed Cell Death 1 Receptor / Q000378:metabolism*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000378:metabolism*; D055815:Young Adult
D015415:Biomarkers; D018959:CD57 Antigens; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor
Biomarker; CD4(+) T cell; CD57; Tuberculosis