Injuries of myocardial cells and changes of myocardial enzymes after firearm wound-induced intestinal perforation in porcine abdomen.
This study aims to observe the changes of myocardial injuries after the firearm wound-induced intestinal perforation in porcine abdomen. 42 healthy Landrace piglets were randomly divided into the control group and the injury group, which was then subdivided into the post-injury 1 h, 2 h, 4 h, 8 h, 12 h and 24 h subgroup. the LDH, CK and CK-MB levels of each group, as well as the plasma endotoxin, were determined and compared. The plasma endotoxin levels of the experimental groups were significantly higher than the control group, and the light microscope observation revealed that the 8 h, 12 h and 24 h subgroup appeared the gradually-aggravated myocardial cell edema and degeneration; the electron microscope revealed that the 4 h, 8 h, 12 h and 24 h subgroup appeared the mitochondrial swelling and dissolution gradually; the serum levels of LDH, CK and CK-MB of each experimental group were higher than the control group. The abdominal firearm wound-induced intestinal perforation would lead to the damaged changes of myocardial morphology and enzymes, which would aggravate as time went along.
First Division, Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
Hui-Chao
HC
Xue
First Division, Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
Ze-Xin
ZX
Li
First Division, Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
Wei-Wei
WW
Zheng
First Division, Department of General Surgery, The First Affiliated Hospital of Xinxiang Medical University Weihui 453100, China.
Yun-Zhen
YZ
Guo
Department of Hepatobiliary Surgery, Urumqi General Hospital of Lanzhou Military Region Urumqi 830000, China.
De-Yuan
DY
Feng
Department of Hepatobiliary Surgery, Urumqi General Hospital of Lanzhou Military Region Urumqi 830000, China.
Jiang-Wei
JW
Liu
Abdominal injury; endotoxin; firearm wound; heart