NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers.
The NOD-like receptors (NLRs) are cytosolic pattern-recognition receptors, which are critically involved in mucosal immune defense. The association of the NLR, NOD2, with inflammatory bowel disease first pointed to the NLRs potential function as guardians of the intestinal barrier. Since then, several studies have emphasized the importance of NLRs in maintaining gut homeostasis and intestinal infections, and in shaping the microbiota. In this review, we will highlight the function of NLRs in intestinal inflammation.
Department of Immunology, University of Toronto, Toronto, Ontario, Canada; Division Models of Inflammation, Leibniz Center for Medicine and Biosciences, Research Center Borstel, Borstel, Germany; and Institute for Experimental Medicine, University of Kiel, Kiel, Germany claes.ak@outlook.com dana.philpott@utoronto.ca.
Anne-Kathrin
AK
Claes
Department of Immunology, University of Toronto, Toronto, Ontario, Canada;
Jun Yu
JY
Zhou
Department of Immunology, University of Toronto, Toronto, Ontario, Canada; claes.ak@outlook.com dana.philpott@utoronto.ca.
Dana J
DJ
Philpott
D000818:Animals; D001419:Bacteria / Q000276:immunology / Q000378:metabolism*; D001424:Bacterial Infections / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D018988:Bacterial Translocation; D005759:Gastroenteritis / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D018928:Immunity, Mucosal; D058847:Inflammasomes / Q000276:immunology / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D053472:Nod Signaling Adaptor Proteins / Q000276:immunology / Q000378:metabolism*; D010539:Permeability; D015398:Signal Transduction
D058847:Inflammasomes; D053472:Nod Signaling Adaptor Proteins