title: Effect of vitamin d3 supplement in glycemic control of pediatrics with type 1 diabetes mellitus and vitamin d deficiency.
abstract: BACKGROUND
  Glycemic control prevents microvascular complications in patients with type I diabetes mellitus such as retinopathy, nephropathy and neuropathy that influences quality of life. Some studies show the immunomodulatory effect of vitamin D in synthesis and secretion of insulin.
  
  
  OBJECTIVE
  In this study we evaluate glycemic changes after vitamin D3 supplement in children with type I diabetes mellitus and vitamin D deficiency.
  
  
  METHODS
  In children with type I diabetes mellitus, level of vitamin D and HbA1C was measured. Patients with type I diabetes mellitus who had vitamin D deficiency (25OHD < 50 nmol/lit) treated with 300,000 units of vitamin D3. Calcium supplement (40mg/kg/day) divided in two doses in order to avoid hungry bone was also used. After three months, 25OHD and HbA1C were measured again. Differences, in mean ± SD HbA1C and 25OHD were evaluated before and after the study.
  
  
  RESULTS
  Mean ± SD HbA1C was 9.73±1.85 before the study which was diminished to 8.55±1.91 after vitamin D3 supplement treatment. This decline has a significant difference (p-value < 0.0001). Mean ± SD 25OHD was 17.33±8.97 nmol/lit before the study which is increased to 39.31±14.38 nmol/lit after treatment with vitamin D3 supplement. This increase also has a significant difference (p-value < 0.0001). Vitamin D3 supplement causes the improvement of HbA1C in all groups of glycemic control including HbA1C <7.8, 7.8-9.9, and >9.9. This supplement transfer patients toward better glycemic control for the entire group (p-value < 0.0001).
  
  
  CONCLUSIONS
  Vitamin D3 supplement improves HbA1C in pediatrics with type I diabetes mellitus and vitamin D deficiency.
authors.affiliation: Associate Professor, Neonatal and Children Health Reasearch Centre, Golestan University of Medical Science, Neonatal and Children Health Research Center , Gorgan, Iran .
authors.forename: Sakineh
authors.initials: S
authors.lastname: Mohammadian
authors.affiliation: Pediatric Resident, Neonatal and Children Health Reasearch Centre, Golestan University of Medical Science, Neonatal and Children Health Research Center , Gorgan, Iran .
authors.forename: Nasrin
authors.initials: N
authors.lastname: Fatahi
authors.affiliation: Assistant Professor, Neonatal and Children Health Reasearch Centre, Golestan University of Medical Science, Neonatal and Children Health Research Center , Gorgan, Iran .
authors.forename: Hossein
authors.initials: H
authors.lastname: Zaeri
authors.affiliation: Assistant Professor, Neonatal and Children Health Reasearch Centre, Golestan University of Medical Science, Neonatal and Children Health Research Center , Gorgan, Iran .
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Vakili
keywords: 25OHD; Children; Glycemic changes; HbA1C