title: OnabotulinumtoxinA intradetrusorial injections improve sexual function in female patients affected by multiple sclerosis: preliminary results.
abstract: OBJECTIVE
  To investigate the effects of onabotulinum toxin type A (Onabot/A) intravesical injections on urinary and sexual function in a group of patients affected by multiple sclerosis (MS).
  
  
  METHODS
  We enrolled 31 MS female patients with symptoms of overactive bladder and detrusor overactivity. All patients underwent urodynamics and were administered 3-day voiding diary, Incontinence Quality of Life (I-QoL) questionnaire, Female Sexual Function Index (FSFI) questionnaire, Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Depression Rating Scale (HAM-D) before and 3 months after Onabot/A intravesical injection.
  
  
  RESULTS
  Onabot/A injection significantly improved urinary symptoms as shown by the 3-day voiding diary, I-QoL questionnaire and the urodynamic variables. In addition, it also significantly improved sexual functioning in continent patients and psychological status as demonstrated by the increase in FSFI, HAM-A and HAM-D scores.
  
  
  CONCLUSIONS
  The Onabot/A-induced positive effect on sexual dysfunction in our MS patients is likely due to an indirect effect exerted by the overall urological clinical improvement on sexual function at both the psychological and emotional levels. The positive effect exerted by Onabot/A on the anxiety and depression scale also suggests that urinary symptoms have a negative impact on the psychological status of the patients.
authors.affiliation: Department of Surgical and Biomedical Sciences, Urology and Andrology Clinic, University of Perugia, Perugia, Italy. agianton@libero.it.
authors.forename: Antonella
authors.initials: A
authors.lastname: Giannantoni
authors.affiliation: Department of Urology, Humanitas Clinical and Research Centre, Milan, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Proietti
authors.affiliation: Department of Urology, Humanitas Clinical and Research Centre, Milan, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Giusti
authors.affiliation: Department of Surgical and Biomedical Sciences, Urology and Andrology Clinic, University of Perugia, Perugia, Italy.
authors.forename: Marilena
authors.initials: M
authors.lastname: Gubbiotti
authors.affiliation: Department of Neurology and Psychiatry, University "La Sapienza", Rome, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Millefiorini
authors.affiliation: Department of Surgical and Biomedical Sciences, Urology and Andrology Clinic, University of Perugia, Perugia, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Costantini
authors.affiliation: Department of Neurology and Psychiatry, University "La Sapienza", Rome, Italy.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Berardelli
authors.affiliation: Department of Neurology and Psychiatry, University "La Sapienza", Rome, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Conte
mesh_terms: D065087:Acetylcholine Release Inhibitors / Q000627:therapeutic use*; D000283:Administration, Intravesical; D000328:Adult; D001007:Anxiety; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D003863:Depression; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D011788:Quality of Life; D019529:Sexuality; D011795:Surveys and Questionnaires; D014555:Urination Disorders / Q000209:etiology / Q000517:prevention & control
chemical_list: D065087:Acetylcholine Release Inhibitors; D019274:Botulinum Toxins, Type A
keywords: Intradetrusorial injections; Multiple sclerosis; OnabotulinumtoxinA; Sexual dysfunction