title: [Expression Changes of β-catenin and P-GSK-3β in Patients with Mantle Cell Lymphoma].
abstract: OBJECTIVE
  This study was purposed to detect the expressions of β-catenin and P-GSK-3 β in Wnt signaling pathway of patients with mantle cell lymphoma(MCL), and investigate its relationship with the pathogenesis of MCL.
  
  
  METHODS
  The expression levels of β -catenin protein and P-GSK-3 protein in mantle cell lymphoma and hyperplastic lymphadenitis were detected by using anti-β-catenin, P-GSK-3β polyclonal antibody and S-P staining technique.
  
  
  RESULTS
  The abnormal expression of β-catenin protein(73.33%) in mantle cell lymphoma group was significantly higher than that (6.7%) in reactive lymph node hyperplasia group (P<0.05); and the positive rate of P-GSK-3 β(66.67%) in mantle cell lymphoma group was significantly higher than that (16.67%) in reactive hyperplasia of lymph node group (P<0.05). Spearman correlation analysis showed that there was obvious positive correlation (R=0.852, P<0.01).
  
  
  CONCLUSIONS
  The abnormal high expressions of β-catenin and P-GSK-3 β protein have been confirmed to appeare in mantle cell lymphoma.
authors.affiliation: Department of Pediatrics, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China.
authors.forename: Jin-Shui
authors.initials: JS
authors.lastname: He
authors.affiliation: Department of Hematology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China.
authors.forename: Yi-Qun
authors.initials: YQ
authors.lastname: Huang
authors.affiliation: Department of Pathology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Weng
authors.affiliation: Department of Pediatrics, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China.
authors.forename: Li-Yun
authors.initials: LY
authors.lastname: Xiao
authors.affiliation: Department of Pediatrics, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China.
authors.forename: Kai-Zhi
authors.initials: KZ
authors.lastname: Weng
authors.affiliation: Department of Hematology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou 363000, Fujian Province, China. E-mail: 353624974@qq.com.
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Ma
mesh_terms: D038362:Glycogen Synthase Kinase 3; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D020522:Lymphoma, Mantle-Cell; D015398:Signal Transduction; D060449:Wnt Signaling Pathway; D051176:beta Catenin
chemical_list: C495270:CTNNB1 protein, human; D051176:beta Catenin; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3