title: Physical exercise reduces synthesis of ADMA, SDMA, and L-Arg.
abstract: Increased levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and low plasma level of L-arginine (L-ARG) are all conditions likely to decrease nitric oxide (NO) production. Aim of this study is to evaluate ADMA, SDMA, and L-ARG plasmatic levels before and after physical exercise in patients with coronary artery disease (CAD). We studied 30 patient with mean age 52 + 4.5 years. After inclusion in the study, before the execution of physical exercise, heparinized blood sample was drawn from an indwelling arterial line for determination of ADMA, L-ARG and SDMA (baseline values). Subsequently a blood sample was drawn after the physical exercise. The mean plasma concentrations of ADMA (0.68 + 0.06 vs 0.48 + 0.05 µmol/L) and SDMA (0.45 + 0.03 vs 0.30 + 0.03 µmol/L) were significantly lower after physical exercise in comparison to baseline value, while L-ARG mean levels were increased (44.20 + 10.5 vs 74.13 + 11.2 µmol/L). Physical exercise has a beneficial effect by reducing plasmatic ADMA and SDMA levels, and increasing L-ARG substrate for endothelial NO.
authors.affiliation: Cardiology Care Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy, griccionI@hotmail.com.
authors.forename: Graziano
authors.initials: G
authors.lastname: Riccioni
authors.forename: Luca
authors.initials: L
authors.lastname: Scotti
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Guagnano
authors.forename: Gabriella
authors.initials: G
authors.lastname: Bosco
authors.forename: Valentina
authors.initials: V
authors.lastname: Bucciarelli
authors.forename: Emanuela
authors.initials: E
authors.lastname: Di Ilio
authors.forename: Lorenza
authors.initials: L
authors.lastname: Speranza
authors.forename: Filippo
authors.initials: F
authors.lastname: Martini
authors.forename: Tonino
authors.initials: T
authors.lastname: Bucciarelli
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000378:metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide; C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine