title: Endoplasmic reticulum-Golgi complex membrane contact sites.
abstract: Although they were identified as long ago as the 1960s, there are still many unknowns regarding the functions and composition of membrane contact sites between the endoplasmic reticulum (ER) and the trans-Golgi (TG). While it seems to be fairly well established that they facilitate lipid exchange between the two organelles, much less is known about how they are regulated. A bottleneck in the study of the ER-TG contact sites has been the absence of methods for their biochemical isolation and visualization by light microscopy. Herein we provide an overview of current knowledge about ER-TG contact sites with a particular emphasis on the questions that remain to be explored.
authors.affiliation: Telethon Institute of Genetics and Medicine, Via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy. Electronic address: dematteis@tigem.it.
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: De Matteis
authors.affiliation: Division of Nephrology and Dialysis, Bambino Gesù Children's Hospital - Scientific Institute, Piazza Sant'Onofrio, 4, 00165 Rome, Italy.
authors.forename: Laura Rita
authors.initials: LR
authors.lastname: Rega
mesh_terms: D000818:Animals; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids
chemical_list: D008055:Lipids