title: A mild and facile synthesis of polyfunctionalized pyridines: merging three-component cyclization and aerobic oxidation by amine/metal catalysts.
abstract: A mild and facile synthesis of polyfunctionalized pyridines from NH4OAc, β,γ-unsaturated α-ketoesters, and ketones/aldehydes has been reported through tandem three-component cyclization and aerobic oxidation using the combination of amine and metal catalysts. The synthetic value of the developed methodology was demonstrated by a gram-scale reaction and a wide range of substrates including naturally occurring citronellal.
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China. zhucycn@gmail.com.
authors.forename: Chunyin
authors.initials: C
authors.lastname: Zhu
authors.forename: Benwei
authors.initials: B
authors.lastname: Bi
authors.forename: Ya
authors.initials: Y
authors.lastname: Ding
authors.forename: Te
authors.initials: T
authors.lastname: Zhang
authors.forename: Qiu-Yun
authors.initials: QY
authors.lastname: Chen