title: Trends in out-of-hospital ischemic heart disease mortality for the 25-64 year old population of Kaunas, Lithuania, based on data from the 1988-2012 Ischemic Heart Disease Registry.
abstract: OBJECTIVE
  The aim of the study was to evaluate trends in out-of-hospital ischemic heart disease (IHD) mortality in the Kaunas, Lithuania population aged 25-64, from 1988 to 2012.
  
  
  METHODS
  The registry was maintained according to the World Health Organisation (WHO) recommendations for the multinational MONICA (MONItoring of trends and determinants in CArdiovascular disease) project. We analysed out-of-hospital deaths from IHD, by sex and age groups, using the linear logistic regression model for identifying trends.
  
  
  RESULTS
  In 1988-2012, the out-of-hospital IHD deaths in Kaunas accounted for 78.4% and 68.4%, on average, of all IHD deaths in men and women aged 25-64, respectively. During the study period, the out-of-hospital IHD mortality for the Kaunas population aged 25-64 was 134.5 per 100,000 men and 18.2 per 100,000 women. From 1988 to 2012, the out-of-hospital IHD mortality for men and women aged 25-64 tended to decline by, on average, 8.3% per year (p = 0.269) and 16.2% per year (p = 0.101), respectively; whereas the corresponding rates for men aged 25-44 were declining significantly, by 22.5% per year (p = 0.047). The most significant changes in out-of-hospital IHD mortality were among men aged 25-44 with no previous history of acute myocardial infarction (AMI), in whom the out-of-hospital IHD mortality was significantly declining, by 21.3% per year (p = 0.015); whereas the corresponding rates for men aged 45-54 with a previous history of AMI tended to decline by 20.4% per year (p = 0.114).
  
  
  CONCLUSIONS
  In 1988-2012, the out-of-hospital IHD deaths of younger men and middle-aged women accounted for the highest percentage of all IHD deaths; and a higher proportion of both men and women with no previous history of AMI, as compared to the proportion of those with a previous history of AMI.
authors.affiliation: Department of Population Studies, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania gailuteb@yahoo.com.
authors.forename: Gailute
authors.initials: G
authors.lastname: Bernotiene
authors.affiliation: Department of Population Studies, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Environmental and Occupational Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Ricardas
authors.initials: R
authors.lastname: Radisauskas
authors.affiliation: Department of Population Studies, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania Department of Preventive Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Abdonas
authors.initials: A
authors.lastname: Tamosiunas
authors.affiliation: Department of Preventive Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Zemyna
authors.initials: Z
authors.lastname: Milasauskiene
mesh_terms: D000328:Adult; D017677:Age Distribution; D005260:Female; D006801:Humans; D008097:Lithuania / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D017202:Myocardial Ischemia / Q000401:mortality*; D012042:Registries; D017678:Sex Distribution
keywords: Acute myocardial infarction; Lithuania; MONICA; World Health Organisation; age; epidemiology; gender; heart attack; ischemic heart disease; mortality; out-of-hospital mortality; registry; sudden death