title: Accelerated Bone Formation in Distracted Alveolar Bone After Injection of Recombinant Human Bone Morphogenetic Protein-2.
abstract: BACKGROUND
  This study evaluates the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on the quality and quantity of regenerated bone when injected into distracted alveolar bone.
  
  
  METHODS
  Sixteen adult beagle dogs were assigned to either the control or rhBMP-2 group. After distraction was completed, an rhBMP-2 dose of 330 μg in 0.33 mL was injected slowly into the distracted alveolar crest of the mesial, middle, and distal parts of the alveolar bone in the experimental group. Histologic and microcomputed tomography analyses of regenerated bone were done after 2 and 6 weeks of consolidation.
  
  
  RESULTS
  After 6 weeks of consolidation, the vertical defect height in the middle of the regenerated bone was significantly lower in the rhBMP-2 group (2.2 mm) than in the control group (3.4 mm) (P <0.05). Additionally, the width of the regenerated bone was significantly greater in the rhBMP-2 group (4.3 mm) than in the control group (2.8 mm) (P <0.05). The bone density and volume of regenerated bone in the rhBMP-2 group were greater than in the control group after 6 weeks of consolidation (P <0.001).
  
  
  CONCLUSIONS
  Injection of rhBMP-2 into regenerated bone after a distraction osteogenesis procedure significantly increased bone volume in the dentoalveolar distraction site and improved both the width and height of the alveolar ridge and increased the bone density.
authors.affiliation: Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Munkhdulam
authors.initials: M
authors.lastname: Terbish
authors.affiliation: Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Seong-Hun
authors.initials: SH
authors.lastname: Yoo
authors.affiliation: Division of Anatomy and Developmental Biology, Department of Oral Biology, Yonsei University.
authors.forename: Hee-Jin
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Hyung-Seog
authors.initials: HS
authors.lastname: Yu
authors.affiliation: Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Chung-Ju
authors.initials: CJ
authors.lastname: Hwang
authors.affiliation: Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Hyung-Seon
authors.initials: HS
authors.lastname: Baik
authors.affiliation: Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, South Korea.
authors.forename: Jung-Yul
authors.initials: JY
authors.lastname: Cha
mesh_terms: D000539:Alveolar Process / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D000818:Animals; D015519:Bone Density / Q000187:drug effects; D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects; D000071556:Cancellous Bone / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D004285:Dogs; D006801:Humans; D007267:Injections; D008437:Maxilla / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D009929:Organ Size; D010012:Osteogenesis / Q000187:drug effects*; D019857:Osteogenesis, Distraction / Q000379:methods*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000627:therapeutic use*; D055114:X-Ray Microtomography / Q000379:methods
chemical_list: D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2
keywords: Bone morphogenetic protein 2; bone regeneration; bone tissue; drug delivery systems; osteogenesis, distraction