title: Is there a role for monocyte chemoattractant protein-1 in delirium? Novel observations in elderly hip fracture patients.
abstract: BACKGROUND
  Delirium is common, associated with poor outcome, but its pathophysiology remains obscure. The aim of the present study was to study a possible role of monocyte chemoattractant protein-1 (MCP-1) in the development of delirium.
  
  
  RESULTS
  A prospective cohort of 19 hip fracture patients (median age 83 years) were screened for delirium daily by validated methods. MCP-1 was measured on arrival and postoperatively. The number of patients with a raise in MCP-1 was statistically significantly higher in the group with delirium in the postoperative phase compared to the no-delirium group (5/6 vs. 1/7, p = .03).
  
  
  CONCLUSIONS
  MCP-1 might play a role in the development of delirium.
authors.affiliation: Oslo Delirium Research Group, Oslo, Norway. kjersti.skrede@so-hf.no.|Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway. kjersti.skrede@so-hf.no.|Faculty of Medicine, University of Oslo, Oslo, Norway. kjersti.skrede@so-hf.no.
authors.forename: Kjersti
authors.initials: K
authors.lastname: Skrede
authors.affiliation: Oslo Delirium Research Group, Oslo, Norway. t.b.wyller@medisin.uio.no.|Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway. t.b.wyller@medisin.uio.no.|Faculty of Medicine, University of Oslo, Oslo, Norway. t.b.wyller@medisin.uio.no.
authors.forename: Torgeir Bruun
authors.initials: TB
authors.lastname: Wyller
authors.affiliation: Oslo Delirium Research Group, Oslo, Norway. l.o.watne@gmail.com.|Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway. l.o.watne@gmail.com.|Faculty of Medicine, University of Oslo, Oslo, Norway. l.o.watne@gmail.com.
authors.forename: Leiv Otto
authors.initials: LO
authors.lastname: Watne
authors.affiliation: Center for Clinical Heart Research, Oslo University Hospital, Oslo, Norway. ingebjorg.seljeflot@ous-hf.no.|Department of Cardiology, Oslo University Hospital, Oslo, Norway. ingebjorg.seljeflot@ous-hf.no.
authors.forename: Ingebjørg
authors.initials: I
authors.lastname: Seljeflot
authors.affiliation: Oslo Delirium Research Group, Oslo, Norway. v.juliebo@gmail.com.|Faculty of Medicine, University of Oslo, Oslo, Norway. v.juliebo@gmail.com.|Department of Cardiology, Oslo University Hospital, Oslo, Norway. v.juliebo@gmail.com.
authors.forename: Vibeke
authors.initials: V
authors.lastname: Juliebø
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018932:Chemokine CCL2 / Q000097:blood*; D003693:Delirium / Q000097:blood*; D005260:Female; D006620:Hip Fractures / Q000097:blood* / Q000601:surgery; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D011184:Postoperative Period; D011300:Preoperative Care
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2