title: Converting a Problem into an Opportunity: mtDNA Heteroplasmy Shift.
abstract: The transmission of mitochondrial DNA (mtDNA) disease from a mother with a heteroplasmic mtDNA mutation to her children is unpredictable. In a recent issue of Cell, Reddy et al. (2015) present the potential for mitochondrial-targeted nucleases to remove mutated mtDNA through the induction of heteroplasmy shift in oocytes and zygotes.
authors.affiliation: Igenomix, Parc Cientific Valencia University, 46980 Paterna, Valencia, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Diez-Juan
authors.affiliation: Igenomix, Parc Cientific Valencia University, 46980 Paterna, Valencia, Spain; Fundación Instituto Valenciano de Infertilidad (FIVI), Department of Obstetrics & Gynecology, School of Medicine, Valencia University and Instituto Universitario IVI/INCLIVA, 46015 Valencia, Spain; Department of Obstetrics and Gynecology, Stanford University, Palo Alto, CA 94304, USA. Electronic address: carlos.simon@uv.es.
authors.forename: Carlos
authors.initials: C
authors.lastname: Simón
mesh_terms: D000818:Animals; D005260:Female; D018390:Gene Targeting; D006801:Humans; D008297:Male; D028361:Mitochondrial Diseases / Q000235:genetics*