title: Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy.
abstract: The rise of antibiotic resistance is a growing public health crisis. Novel antimicrobials are sought, preferably developing nontraditional chemical scaffolds that do not inhibit standard targets such as cell wall synthesis or the ribosome. Iron scavenging has been proposed as a viable target, because bacterial and fungal pathogens must overcome the nutritional immunity of the host to be virulent. This review highlights the recent work toward exploiting the biosynthetic enzymes of siderophore production for the design of next generation antimicrobials.
authors.affiliation: Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA. Electronic address: lamb@ku.edu.
authors.forename: Audrey L
authors.initials: AL
authors.lastname: Lamb
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D025141:Drug Resistance, Fungal / Q000187:drug effects*; D007501:Iron / Q000378:metabolism*; D009181:Mycoses / Q000188:drug therapy / Q000378:metabolism; D017262:Siderophores / Q000096:biosynthesis / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D017262:Siderophores; D007501:Iron
keywords: NRPS-independent synthetase; Nonribosomal peptide synthetase; Polyketide synthase; Siderophore