title: [Efficacy and safety of ciprofloxacin treatment in urinary tract infections (UTIs) in adults: a systematic review with meta-analysis].
abstract: OBJECTIVE
  A systematic review with meta-analysis of randomized controlled trials (RGT) on the efficacy and safety of ciprofloxacin in the treatment of acute or complicated urinary tract infections in adults. Primary outcomes were bacteriological eradication, clinical cure, bacterial resistance, and adverse event rates.
  
  
  RESULTS
  Initially, 111 RGTs were identified. We excluded 81 studies due to low quality methodology. An analysis of the remaining RGTs identified therapeutic equivalence of ciprofloxacin against other antimicrobials in terms of bacterial eradication and clinical cure at the end of treatment and in subsequent stages. The percentage of bacterial resistance was similar in both groups, while the percentage of related adverse events was significantly lower in the groups treated with ciprofloxacin.
  
  
  CONCLUSIONS
  We conclude that ciprofloxacin is a safe and effective therapeutic alternative for the treatment of acute or complicated urinary tract infections in adults.
authors.affiliation: Hospital General Dr. Manuel Gea González, México, D.F., Mexico.
authors.forename: Pedro
authors.initials: P
authors.lastname: Gutiérrez-Castrellón
authors.affiliation: Instituto Nacional de Pediatría, Secretaría de Salud, México, D.F., Mexico.
authors.forename: Luisa
authors.initials: L
authors.lastname: Díaz-García
authors.affiliation: Instituto Nacional de Pediatría, Secretaría de Salud, México, D.F., Mexico.
authors.forename: Agustín
authors.initials: A
authors.lastname: de Colsa-Ranero
authors.affiliation: Instituto Nacional de Pediatría, Secretaría de Salud, México, D.F., Mexico.
authors.forename: Juan
authors.initials: J
authors.lastname: Cuevas-Alpuche
authors.affiliation: Hospital General Dr. Manuel Gea González, México, D.F., Mexico.
authors.forename: Irma
authors.initials: I
authors.lastname: Jiménez-Escobar
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin