title: MPO-ANCA crescentic glomerulonephritis complicated by membranous nephropathy: MPO demonstrated in epimembranous deposits.
abstract: An elderly woman presented with haematuria and proteinuria accompanied by elevated serum myeloperoxidase (MPO)-specific anti-neutrophil cytoplasmic antibodies (MPO-ANCA). A renal biopsy revealed mild mesangial proliferation with fibrocellular crescent formation and a membranous glomerular lesion. Immunofluorescence microscopy using FITC-labelled rabbit anti-human MPO antibodies revealed granular MPO deposition along the glomerular capillary walls (GCW) with a staining profile similar to that of glomerular IgG deposition. The one-year follow-up renal biopsy revealed minimal IgG and undetectable MPO deposition. Both MPO and MPO-ANCA might have been responsible for the IgG immune depositions along the GCW in this patient.
authors.affiliation: Division of Nephrology, Department of Medicine , Showa University School of Medicine , 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666 , Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Division of Nephrology, Department of Medicine , Showa University School of Medicine , 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666 , Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Honda
authors.affiliation: Division of Nephrology, Department of Medicine , Showa University School of Medicine , 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666 , Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Shibata
authors.affiliation: Division of Nephrology, Department of Medicine , Showa University School of Medicine , 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666 , Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sanada
authors.affiliation: Division of Nephrology, Department of Medicine , Showa University School of Medicine , 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666 , Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Wada
authors.affiliation: Division of Nephrology, Department of Medicine , Showa University School of Medicine , 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666 , Japan.
authors.forename: Eijin
authors.initials: E
authors.lastname: Ashikaga
authors.affiliation: Division of Nephrology, Department of Medicine , Showa University School of Medicine , 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666 , Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Kuroki
authors.affiliation: Division of Nephrology, Department of Medicine , Showa University School of Medicine , 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666 , Japan.
authors.forename: Kozo
authors.initials: K
authors.lastname: Kitazawa
authors.affiliation: Division of Nephrology, Department of Medicine , Showa University School of Medicine , 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666 , Japan.
authors.forename: Tadao
authors.initials: T
authors.lastname: Akizawa
keywords: MPO-ANCA; membranous glomerulopathy; myeloperoxidase