title: Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol.
abstract: A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a trifluoroethanol-derived active ester intermediate.
authors.affiliation: Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK. craig.jamieson@strath.ac.uk.
authors.forename: Nicola
authors.initials: N
authors.lastname: Caldwell
authors.forename: Craig
authors.initials: C
authors.lastname: Jamieson
authors.forename: Iain
authors.initials: I
authors.lastname: Simpson
authors.forename: Allan J B
authors.initials: AJ
authors.lastname: Watson
mesh_terms: D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D004952:Esters; D005663:Furans / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry; D017680:Potassium Compounds / Q000737:chemistry; D013696:Temperature; D014270:Trifluoroethanol / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D004952:Esters; D005663:Furans; D010710:Phosphates; D017680:Potassium Compounds; C018674:tetrahydrofuran; D014270:Trifluoroethanol; C013216:potassium phosphate