title: Effect of serum testosterone and percent tumor volume on extra-prostatic extension and biochemical recurrence after laparoscopic radical prostatectomy.
abstract: Several studies have revealed that the preoperative serum testosterone and percent tumor volume (PTV) predict extra-prostatic extension (EPE) and biochemical recurrence (BCR) after radical prostatectomy. This study investigated the prognostic significance of serum testosterone and PTV in relation to EPE and BCR after laparoscopic radical prostatectomy (LRP). We reviewed 520 patients who underwent LRP between 2004 and 2012. PTV was determined as the sum of all visually estimated tumor foci in every section. BCR was defined as two consecutive increases in the postoperative prostate-specific antigen (PSA) >0.2 ng ml-1 . The threshold for serum total testosterone was 3.0 ng ml-1 . Multivariate logistic regression was used to define the effect of variables on the risk of EPE and BCR. A low serum testosterone (<3.0 ng ml-1 ) was associated with a high serum PSA, Gleason score, positive core percentage of the prostate biopsy, PTV, and all pathological variables. On multivariate analysis, similar to previous studies, the serum PSA, biopsy positive core percentage, Gleason score, and pathological variables predicted EPE and BCR. In addition, low serum testosterone (<3.0 ng ml-1 , adjusted OR, 8.52; 95% CI, 5.04-14.4, P= 0.001) predicted EPE and PTV (adjusted OR, 1.02; 95% CI, 1.01-1.05, P= 0.046) predicted BCR. In addition to previous predictors of EPE and BCR, low serum testosterone and PTV are valuable predictors of EPE and BCR after LRP.
authors.forename: Eu Chang
authors.initials: EC
authors.lastname: Hwang
authors.forename: Seong Hyeon
authors.initials: SH
authors.lastname: Yu
authors.forename: Yang Hyun
authors.initials: YH
authors.lastname: Jo
authors.forename: Seung Il
authors.initials: SI
authors.lastname: Jung
authors.forename: Taek Won
authors.initials: TW
authors.lastname: Kang
authors.affiliation: Department of Urology, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Dong Deuk
authors.initials: DD
authors.lastname: Kwon
authors.forename: Chan
authors.initials: C
authors.lastname: Choi
authors.forename: Suk Hee
authors.initials: SH
authors.lastname: Heo
authors.forename: Jun Eul
authors.initials: JE
authors.lastname: Hwang
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Jung
authors.forename: Tae-Young
authors.initials: TY
authors.lastname: Jung
mesh_terms: D000368:Aged; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D012008:Recurrence; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone