title: To study the prevalence of impaired glucose tolerance in patients with hepatitis C virus related chronic liver disease.
abstract: BACKGROUND
  Hepatitis C infection is a major cause of Chronic Liver Disease and the prevalence of Diabetes Mellitus is also high. Diabetes has been hypothesised as one of Extrahepatic manifestations of Hepatitis C.
  
  
  OBJECTIVE
  The objective of our study was to study the prevalence of impaired glucose tolerance in patients with HCV related liver disease.
  
  
  METHODS
  The study was a prospective study conducted over a period of one and half year in Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
  
  
  METHODS
  The study was conducted taking total of 100 Hepatitis C virus positive patients above 40 years of age who had fasting blood glucose levels ≥110mg/dl on two occasions, 24 hours apart. These patients underwent an oral glucose tolerance test. Blood sugar levels were tested at 0 and 2 hours. Based on the findings, patients were classified to have impaired glucose tolerance if levels were between 140-200mg/dl and frank diabetes if the levels were ≥ 200mg/dl. These findings were further assessed according to age, gender, Body Mass Index (BMI) Child Turcott Pugh score and Ultrasonography findings.
  
  
  METHODS
  In our study all the statistical analysis was done using simple z-test and student t-test. The p-values were calculated and the results assessed accordingly.
  
  
  CONCLUSIONS
  Out of 100 patients, 78 were males and rest females. The mean age of the study group was 55.89±11.22 years. Mean BMI of males was higher than in females (21.98kg/m² v/s 20.13kg/m²). Maximum patients belonged to Child Turcott Pugh class C. Out of 100 patients,80 had cirrhosis on ultrasound. On doing Glucose Tolerance Test, 40 patients were found to have impaired glucose tolerance and one patient to be diabetic. The prevalence increased significantly as age increased and had significant relation with gender. On assessing according to BMI, there was not much significant relation but prevalence was significantly related to severity of disease.
authors.affiliation: Attending Consultant, Department of Internal Medicine, Fortis Hospital , Ludhiana, India .
authors.forename: Harpreet
authors.initials: H
authors.lastname: Kaur
authors.affiliation: Professor and Head, Department of Endocrinology, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Parminder
authors.initials: P
authors.lastname: Singh
authors.affiliation: Professor, Department of Internal Medicine, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Harminder Singh
authors.initials: HS
authors.lastname: Pannu
authors.affiliation: Professor and Head, Department of Gastroenterology, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Ajit
authors.initials: A
authors.lastname: Sood
authors.affiliation: Professor, Department of Internal Medicine, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Narender Pal
authors.initials: NP
authors.lastname: Jain
authors.affiliation: Post Graduate, Department of Pediatrics, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Harpreet Singh
authors.initials: HS
authors.lastname: Bhoday
keywords: Diabetes mellitus; Extrahepatic manifestations; Hepatitis C; Impaired glucose tolerance