title: A Gonadotropin-Releasing Hormone (GnRH) Stimulation Test Before and After GnRH Analogue Treatment for Central Precocious Puberty: Has the GnRH Test been Adequately Simplified?
abstract: OBJECTIVE
  To investigate and simplify the gonadotropin-releasing hormone (GnRH) stimulation test for assessing pubertal activation and suppression.
  
  
  METHODS
  The authors identified 72 girls diagnosed with central precocious puberty who were treated with a GnRH analogue (GnRHa). Patients who underwent an assessment regarding GnRHa-mediated puberty suppression had been diagnosed via the GnRH stimulation test prior to GnRHa treatment. The authors analyzed the diagnostic values of the during/before-treatment LH levels at different time points by a receiver-operating characteristic (ROC) curve.
  
  
  RESULTS
  Before GnRHa treatment, the mean luteinizing hormone (LH) level was higher at the 30-min test time point than at baseline or the 15, 60, 90, and 120-min points (P < 0.001). After GnRHa treatment, the LH levels were suppressed in 62 patients (86.1%) and inadequately suppressed in 10 (13.9%). The LH level was higher at the 30-min test time point than those at baseline or the 45 and 60-min level (P < 0.001). The area under the curve in a post-GnRHa treatment was greatest at 30 min.
  
  
  CONCLUSIONS
  The simplified GnRH test is adequate for evaluating pubertal activation (30 and/or 45-min time points of the GnRH test) and suppression (the 30-min time point).
authors.affiliation: Department of Pediatrics, Chonbuk National University Medical School, 634-18 Keumam-dong, Jeonju, 561-712, Korea.|Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Institute of Chonbuk National University Hospital, Jeonju, 561-712, Korea.
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Chonbuk National University Medical School, 634-18 Keumam-dong, Jeonju, 561-712, Korea.|Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Institute of Chonbuk National University Hospital, Jeonju, 561-712, Korea.
authors.forename: Pyoung Han
authors.initials: PH
authors.lastname: Hwang
authors.affiliation: Department of Pediatrics, Chonbuk National University Medical School, 634-18 Keumam-dong, Jeonju, 561-712, Korea. leedy@jbnu.ac.kr.|Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Institute of Chonbuk National University Hospital, Jeonju, 561-712, Korea. leedy@jbnu.ac.kr.
authors.forename: Dae-Yeol
authors.initials: DY
authors.lastname: Lee
mesh_terms: D002648:Child; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D011629:Puberty, Precocious / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D012372:ROC Curve
chemical_list: D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: Girl; Gonadotropin-releasing hormone; Gonadotropin-releasing hormone stimulation test; Precocious puberty