title: EBV+ diffuse large B-cell lymphoma arising within atrial myxoma in Chinese immunocompetent patient.
abstract: The incidence rate of Primary cardiac lymphoma is very low. Primary cardiac lymphoma within myxoma is extremely rare disease. So far, these cases have been reported only eight in the world, which has not reported in Chinese so far. Hence, we reported the unique Chinese case of 52-year-old immunocompetent male with primary Epstein-Barr virus positive diffuse large B-cell lymphoma arising within atrial myxoma, and had no evidence of systemic lymphoma. The patient presented right sided body numbness, arm weakness no incentive and mouth twitch. A transthoracic echocardiogram revealed a large intraatrial mass, attached to the left atrial wall. The mass was removed by open thoracic surgery and subsequently diagnosed as malignant diffuse large B-cell lymphoma with myxoma by histopathology. This was the fourth case of discovered Epstein-Barr virus positive diffuse large B-cell lymphoma in a cardiac myxoma reported so far. The patient has been well by followed up for 5 months without chemotherapy. Now we discuss the importance of histodiagnosis and the proper treatment. Epstein-Barr virus positive diffuse large B-cell lymphoma arising within atrial myxoma is an extraordinary lymphoma for better prognosis, avoiding excessive treatment.
authors.affiliation: Department of Pathology, The First Affliated Hospital, Zhejiang University Medical College Hangzhou, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Pathology, The First Affliated Hospital, Zhejiang University Medical College Hangzhou, China.
authors.forename: Pu
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Pathology, The First Affliated Hospital, Zhejiang University Medical College Hangzhou, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
mesh_terms: D006325:Heart Atria / Q000473:pathology* / Q000821:virology; D006338:Heart Neoplasms / Q000473:pathology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000473:pathology* / Q000821:virology; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000821:virology
keywords: Chinese; Epstein-Barr virus; Primary cardiac lymphoma; atrial myxoma; diffuse large B-cell lymphoma; histopathology