title: Light Weight and Flexible High-Performance Diagnostic Platform.
abstract: A flexible diagnostic platform is realized and its performance is demonstrated for early detection of avian influenza virus (AIV) subtype H1N1 DNA sequences. The key component of the platform is high-performance biosensors based on high output currents and low power dissipation Si nanowire field effect transistors (SiNW-FETs) fabricated on flexible 100 μm thick polyimide foils. The devices on a polymeric support are about ten times lighter compared to their rigid counterparts on Si wafers and can be prepared on large areas. While the latter potentially allows reducing the fabrication costs per device, the former makes them cost efficient for high-volume delivery to medical institutions in, e.g., developing countries. The flexible devices withstand bending down to a 7.5 mm radius and do not degrade in performance even after 1000 consecutive bending cycles. In addition to these remarkable mechanical properties, on the analytic side, the diagnostic platform allows fast detection of specific DNA sequences of AIV subtype H1N1 with a limit of detection of 40 × 10(-12) m within 30 min suggesting its suitability for early stage disease diagnosis.
authors.affiliation: Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstr. 20, 01069, Dresden, Germany.
authors.forename: Daniil
authors.initials: D
authors.lastname: Karnaushenko
authors.affiliation: Institute for Materials Science and Max Bergmann Center of Biomaterials, Dresden University of Technology, Budapesterstr. 27, 01062, Dresden, Germany.|Center for Advancing Electronics Dresden (CfAED), Dresden University of Technology, 01062, Dresden, Germany.
authors.forename: Bergoi
authors.initials: B
authors.lastname: Ibarlucea
authors.affiliation: Institute for Materials Science and Max Bergmann Center of Biomaterials, Dresden University of Technology, Budapesterstr. 27, 01062, Dresden, Germany.
authors.forename: Sanghun
authors.initials: S
authors.lastname: Lee
authors.affiliation: Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstr. 20, 01069, Dresden, Germany.
authors.forename: Gungun
authors.initials: G
authors.lastname: Lin
authors.affiliation: Institute for Materials Science and Max Bergmann Center of Biomaterials, Dresden University of Technology, Budapesterstr. 27, 01062, Dresden, Germany.
authors.forename: Larysa
authors.initials: L
authors.lastname: Baraban
authors.affiliation: Institute for Materials Science and Max Bergmann Center of Biomaterials, Dresden University of Technology, Budapesterstr. 27, 01062, Dresden, Germany.|Center for Advancing Electronics Dresden (CfAED), Dresden University of Technology, 01062, Dresden, Germany.|Namlab GmbH, Nöthnitzerstraße 64, 01187, Dresden, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Pregl
authors.affiliation: Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstr. 20, 01069, Dresden, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Melzer
authors.affiliation: Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstr. 20, 01069, Dresden, Germany.
authors.forename: Denys
authors.initials: D
authors.lastname: Makarov
authors.affiliation: Center for Advancing Electronics Dresden (CfAED), Dresden University of Technology, 01062, Dresden, Germany.|Namlab GmbH, Nöthnitzerstraße 64, 01187, Dresden, Germany.
authors.forename: Walter M
authors.initials: WM
authors.lastname: Weber
authors.affiliation: Center for Advancing Electronics Dresden (CfAED), Dresden University of Technology, 01062, Dresden, Germany.|Namlab GmbH, Nöthnitzerstraße 64, 01187, Dresden, Germany.|Institute for Semiconductors and Microsystems, Dresden University of Technology, 01062, Dresden, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Mikolajick
authors.affiliation: Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstr. 20, 01069, Dresden, Germany.|Center for Advancing Electronics Dresden (CfAED), Dresden University of Technology, 01062, Dresden, Germany.|Material Systemsfor Nanoelectronics, Chemnitz University of Technology, Reichenhainer Str. 70, 09107, Chemnitz, Germany.
authors.forename: Oliver G
authors.initials: OG
authors.lastname: Schmidt
authors.affiliation: Institute for Materials Science and Max Bergmann Center of Biomaterials, Dresden University of Technology, Budapesterstr. 27, 01062, Dresden, Germany.|Center for Advancing Electronics Dresden (CfAED), Dresden University of Technology, 01062, Dresden, Germany.|Dresden Center for Computational Materials Science (DCCMS), Dresden University of Technology, 01062, Dresden, Germany.
authors.forename: Gianaurelio
authors.initials: G
authors.lastname: Cuniberti
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000302:isolation & purification; D007251:Influenza, Human / Q000175:diagnosis* / Q000821:virology; D053770:Nanowires / Q000737:chemistry; D012825:Silicon / Q000737:chemistry; D014173:Transistors, Electronic
chemical_list: D004279:DNA, Viral; D012825:Silicon
keywords: avian influenza virus; biosensors; field effect transistors; flexible electronics; nanowires