title: Arterial stiffness in periodontitis patients and controls. A case–control and pilot intervention study.
abstract: Increased arterial stiffness (AS) is an important indicator for atherosclerotic cardiovascular disease (ACVD). Epidemiologically, periodontitis and ACVD are associated. Therefore, we aimed to investigate AS in periodontitis patients and controls. In addition, we explored the effect of periodontal therapy on AS in a sub-group of cases. Pulse-wave velocity (PWV), a non-invasive chair-side function test for AS, was measured in periodontitis patients (n=57; mean age 46.6 years) and compared with a reference group (n=48; mean age 45.5 years). In addition, 45 cases (mean age 46.9 years) were 6 months followed after periodontal treatment, to explore a possible effect on arterial function. Periodontitis patients showed a significantly increased PWV compared with the reference group (8.01±0.20 vs. 7.36±0.22 m s(-1) respectively; P=0.029) and this remained significant after adjustments for ACVD risk factors (P=0.019). After periodontal therapy, no significant reduction in PWV was seen (8.00±1.8 to 7.82±1.6 m s(-1); P=0.13), but systolic blood pressure (SBP) was significantly reduced (119.8±14.6 to 116.9±15.1 mm Hg; P=0.040). It can be concluded that periodontitis is associated with increased AS. This confirms with a new parameter the association of periodontitis with ACVD. Although periodontal treatment did not lower AS significantly, a modest reduction of SBP after 6 months was observed.
authors.affiliation: Department of Periodontology, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Houcken
authors.affiliation: Department of Periodontology, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands.
authors.forename: W J
authors.initials: WJ
authors.lastname: Teeuw
authors.affiliation: Department of Periodontology, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Bizzarro
authors.affiliation: Department of Periodontology, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Alvarez Rodriguez
authors.affiliation: Department of Vascular Medicine, Academic Medical Centre (AMC), University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: T A
authors.initials: TA
authors.lastname: Mulders
authors.affiliation: Department of Vascular Medicine, Academic Medical Centre (AMC), University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: B-Jh
authors.initials: BJ
authors.lastname: van den Born
authors.affiliation: Department of Periodontology, Academic Centre of Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands.
authors.forename: B G
authors.initials: BG
authors.lastname: Loos
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000453:epidemiology* / Q000628:therapy*; D010865:Pilot Projects; D063177:Pulse Wave Analysis; D018570:Risk Assessment; D012307:Risk Factors; D059289:Vascular Stiffness
chemical_list: D015415:Biomarkers