title: Efficacy of combined hepatitis B immunoglobulin and hepatitis B vaccine in blocking father-infant transmission of hepatitis B viral infection.
abstract: The aim of this study was to examine the efficacy of combined immunization of hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine (HBVac) in blocking father-infant transmission of hepatitis B virus (HBV). Newborns positive at birth for blood HBV sur-face antigen (HBsAg) and/or HBV DNA were selected and immunized with HBIG combination HBVac. At 7 months, HBV markers and HBV DNA of each neonate were measured using electrochemiluminescence with the Cobas-e-411 Automatic Electrochemiluminescence Immuno-assay Analyzer and fluorescence quantitative polymerase chain reaction. Among all 7-month-old subjects, the negative conversion rates of HBV DNA and HBsAg were 48/61 (78.7%) and 19/41 (46.3%), respectively. Therefore, this study demonstrated that prompt combination injection of HBIG and HBVac can protect some of the HBV DNA- and/ or HBsAg-positive newborns from HBV.
authors.affiliation: Hepatic Disease Center, The Third Hospital of Qinhuangdao City, Hebei, Qinhuangdao, China caolihua_clh@163.com.
authors.forename: L-H
authors.initials: LH
authors.lastname: Cao
authors.affiliation: Hepatic Disease Center, The Third Hospital of Qinhuangdao City, Hebei, Qinhuangdao, China.
authors.forename: Z-M
authors.initials: ZM
authors.lastname: Liu
authors.affiliation: Hepatic Disease Center, The Third Hospital of Qinhuangdao City, Hebei, Qinhuangdao, China.
authors.forename: P-L
authors.initials: PL
authors.lastname: Zhao
authors.affiliation: Maternal and Child Hospital of Qinhuangdao City, Hebei, Qinhuangdao, China.
authors.forename: S-C
authors.initials: SC
authors.lastname: Sun
authors.affiliation: Hepatic Disease Center, The Third Hospital of Qinhuangdao City, Hebei, Qinhuangdao, China.
authors.forename: D-B
authors.initials: DB
authors.lastname: Xu
authors.affiliation: Hepatic Disease Center, The Third Hospital of Qinhuangdao City, Hebei, Qinhuangdao, China.
authors.forename: M-H
authors.initials: MH
authors.lastname: Shao
authors.affiliation: Hepatic Disease Center, The Third Hospital of Qinhuangdao City, Hebei, Qinhuangdao, China.
authors.forename: J-D
authors.initials: JD
authors.lastname: Zhang
mesh_terms: D005220:Fathers; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control* / Q000635:transmission; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D007231:Infant, Newborn; D008297:Male
chemical_list: D017325:Hepatitis B Vaccines; D007136:Immunoglobulins