title: Effects of hydraulic pressure on cardiomyoblasts in a microfluidic device.
abstract: We employed a microfluidic device to study the effects of hydraulic pressure on cardiomyoblast H9c2. The 170 mm Hg pressure increased the cellular area and the expression of atrial natriuretic peptide. With the same device, we demonstrated that the effects of hydraulic pressure on the cardiomyoblast could be reduced by the inhibitor of focal adhesion kinase. This mechanical-chemical antagonism could lead to a potential therapeutic strategy of hypertension-induced cardiac hypertrophy.
authors.forename: Yu-Fang
authors.initials: YF
authors.lastname: Hsiao
authors.affiliation: Research Center for Applied Sciences , Academia Sinica, Taipei 11529, Taiwan.
authors.forename: Huei-Jyuan
authors.initials: HJ
authors.lastname: Pan
authors.affiliation: Research Center for Applied Sciences , Academia Sinica, Taipei 11529, Taiwan.
authors.forename: Yi-Chung
authors.initials: YC
authors.lastname: Tung
authors.affiliation: Institute of Biomedical Sciences , Academia Sinica, Taipei 11529, Taiwan.
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Chen
authors.forename: Chau-Hwang
authors.initials: CH
authors.lastname: Lee