title: The ins and outs of osteopontin.
abstract: The continuous remodeling of progressing tumors demands non-physiologic production of extracellular matrix (ECM) proteins. Among them, osteopontin (OPN) has been largely involved in tumor progression and metastasis. We have recently discovered a new mechanism for OPN in the metastatic spread of mammary carcinoma providing local immunosuppression at the seeding site.
authors.affiliation: Molecular Immunology Unit; Department of Experimental Oncology and Molecular Medicine; Fondazione IRCCS Istituto Nazionale Tumori ; Milan, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Chiodoni
authors.affiliation: Molecular Immunology Unit; Department of Experimental Oncology and Molecular Medicine; Fondazione IRCCS Istituto Nazionale Tumori ; Milan, Italy.
authors.forename: Sabina
authors.initials: S
authors.lastname: Sangaletti
authors.affiliation: Tumor Immunology Unit; Human Pathology Section; Department of Health Sciences; University of Palermo ; Palermo, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Tripodo
authors.affiliation: Molecular Immunology Unit; Department of Experimental Oncology and Molecular Medicine; Fondazione IRCCS Istituto Nazionale Tumori ; Milan, Italy.
authors.forename: Mario P
authors.initials: MP
authors.lastname: Colombo
keywords: metastasis; myeloid-derived suppressor cells; osteopontin