title: Dietary Supplementation of Walnut Partially Reverses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Neurodegeneration in a Mouse Model of Parkinson's Disease.
abstract: Numerous studies indicating that natural plant sources and their active phytochemicals offer protection to the pathological processes related to the development of neurogenerative diseases including Parkinson's disease (PD). In the present study, the neuro protective efficacy of dietary supplementation of walnut (6 %) for 28 days was examined in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (i.p., 20 mg/kg body weight/day) for last four consecutive days. MPTP injection diminished the levels of GSH, dopamine and metabolites along with decreased activities of GPx and mitochondrial complex I. Further, the levels of TBARS and enzymatic antioxidants such as SOD and catalase, MAO-B activities were enhanced by MPTP treatment. Behavioral deficits and lowered TH expression are also proved MPTP induced neurotoxicity. Dietary supplementation of walnut attenuated MPTP-induced impairment in PD mice might be by its MAO-B inhibitory, antioxidant and mitochondrial protective actions. To find out the exact mechanism of action walnut on PD mice warrants further extensive studies.
authors.affiliation: Department of Food Science and Nutrition, College of Agricultural and Marine Sciences (CAMS), Sultan Qaboos University, P.O. 34, Al-Khoud, Muscat, 123, Sultanate of Oman, drmdessa@gmail.com.
authors.forename: Musthafa Mohamed
authors.initials: MM
authors.lastname: Essa
authors.forename: Selvaraju
authors.initials: S
authors.lastname: Subash
authors.forename: Chinnasamy
authors.initials: C
authors.lastname: Dhanalakshmi
authors.forename: Thamilarasan
authors.initials: T
authors.lastname: Manivasagam
authors.forename: Samir
authors.initials: S
authors.lastname: Al-Adawi
authors.forename: Gilles J
authors.initials: GJ
authors.lastname: Guillemin
authors.forename: Arokiasamy
authors.initials: A
authors.lastname: Justin Thenmozhi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D019587:Dietary Supplements; D004298:Dopamine / Q000378:metabolism; D042967:Electron Transport Complex I / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D031324:Juglans / Q000737:chemistry*; D020267:MPTP Poisoning / Q000188:drug therapy* / Q000523:psychology; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000494:pharmacology; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008996:Monoamine Oxidase Inhibitors; D018696:Neuroprotective Agents; D010936:Plant Extracts; D014446:Tyrosine 3-Monooxygenase; D042967:Electron Transport Complex I; D005978:Glutathione; D004298:Dopamine