title: Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.
abstract: Choroid plexus carcinomas (CPCs) are poorly understood and frequently lethal brain tumors with few treatment options. Using a mouse model of the disease and a large cohort of human CPCs, we performed a cross-species, genome-wide search for oncogenes within syntenic regions of chromosome gain. TAF12, NFYC, and RAD54L co-located on human chromosome 1p32-35.3 and mouse chromosome 4qD1-D3 were identified as oncogenes that are gained in tumors in both species and required for disease initiation and progression. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair. Our data identify a group of concurrently gained oncogenes that cooperate in the formation of CPC and reveal potential avenues for therapy.
authors.affiliation: Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: Yiai
authors.initials: Y
authors.lastname: Tong
authors.affiliation: Genetics and Genome Biology Program, The Hospital for Sick Children, Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1X8, Canada.
authors.forename: Diana
authors.initials: D
authors.lastname: Merino
authors.affiliation: Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: Birgit
authors.initials: B
authors.lastname: Nimmervoll
authors.affiliation: Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: Kirti
authors.initials: K
authors.lastname: Gupta
authors.affiliation: Department of Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Wang
authors.affiliation: Department of Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: David
authors.initials: D
authors.lastname: Finkelstein
authors.affiliation: Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: James
authors.initials: J
authors.lastname: Dalton
authors.affiliation: Department of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Ellison
authors.affiliation: Department of Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: Xiaotu
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Computational Biology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: Jinghui
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Genetics and Genome Biology Program, The Hospital for Sick Children, Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1X8, Canada; Division of Hematology/Oncology, The Hospital for Sick Children, Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1X8, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Malkin
authors.affiliation: Department of Developmental Neurobiology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA; Department of Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address: richard.gilbertson@stjude.org.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Gilbertson
mesh_terms: D000818:Animals; D001483:Base Sequence; D023081:CCAAT-Binding Factor / Q000235:genetics*; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology; D049109:Cell Proliferation / Q000235:genetics; D016545:Choroid Plexus Neoplasms / Q000235:genetics* / Q000473:pathology; D002874:Chromosome Mapping; D004265:DNA Helicases / Q000235:genetics*; D017931:DNA Primers; D004268:DNA-Binding Proteins; D023281:Genomics; D006801:Humans; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D009857:Oncogenes; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013045:Species Specificity; D035381:TATA-Binding Protein Associated Factors / Q000235:genetics*
chemical_list: D023081:CCAAT-Binding Factor; D017931:DNA Primers; D004268:DNA-Binding Proteins; C469358:NFYC protein, human; D009687:Nuclear Proteins; C470012:TAF12 protein, human; D035381:TATA-Binding Protein Associated Factors; D004265:DNA Helicases; C103532:RAD54L protein, human