title: Principles of chromatin organization in yeast: relevance of polymer models to describe nuclear organization and dynamics.
abstract: Nuclear organization can impact on all aspects of the genome life cycle. This organization is thoroughly investigated by advanced imaging and chromosome conformation capture techniques, providing considerable amount of datasets describing the spatial organization of chromosomes. In this review, we will focus on polymer models to describe chromosome statics and dynamics in the yeast Saccharomyces cerevisiae. We suggest that the equilibrium configuration of a polymer chain tethered at both ends and placed in a confined volume is consistent with the current literature, implying that local chromatin interactions play a secondary role in yeast nuclear organization. Future challenges are to reach an integrated multi-scale description of yeast chromosome organization, which is crucially needed to improve our understanding of the regulation of genomic transaction.
authors.affiliation: LBME du CNRS, France; Laboratoire de Biologie Moleculaire Eucaryote, Université de Toulouse, 118 route de Narbonne, F-31000 Toulouse, France.
authors.forename: Renjie
authors.initials: R
authors.lastname: Wang
authors.affiliation: Laboratory for Theoretical Physics of Condensed Matter UMR7600, Sorbonne University, UPMC, 75005 Paris, France; Groupement de recherche Architecture et Dynamique Nucléaire (GDR ADN), France.
authors.forename: Julien
authors.initials: J
authors.lastname: Mozziconacci
authors.affiliation: Groupement de recherche Architecture et Dynamique Nucléaire (GDR ADN), France; CNRS, LAAS, 7 avenue du colonel Roche, F-31400 Toulouse, France; Univ de Toulouse, LAAS, F-31400 Toulouse, France.
authors.forename: Aurélien
authors.initials: A
authors.lastname: Bancaud
authors.affiliation: LBME du CNRS, France; Laboratoire de Biologie Moleculaire Eucaryote, Université de Toulouse, 118 route de Narbonne, F-31000 Toulouse, France; Groupement de recherche Architecture et Dynamique Nucléaire (GDR ADN), France. Electronic address: gadal@biotoul.fr.
authors.forename: Olivier
authors.initials: O
authors.lastname: Gadal
mesh_terms: D000818:Animals; D002843:Chromatin; D002875:Chromosomes; D016681:Genome, Fungal; D006801:Humans; D008954:Models, Biological; D011108:Polymers / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism
chemical_list: D002843:Chromatin; D011108:Polymers