title: Adsorption mechanisms of emerging micro-pollutants with a clay mineral: Case of tramadol and doxepine pharmaceutical products.
abstract: A sodium exchanged smectite clay mineral (Mt) was used as geo-sorbent for the adsorption of tramadol and doxepin: two pharmaceutical products (PPs) defined as emerging pollutants due to their presence at significant concentration in numerous water compartments. The adsorption isotherms for both the temperatures of 20 and 40°C and the derived data determined through the fitting procedure by using Langmuir, Freundlich and Dubinin-Radushkevich equation models explicitly pointed out that the sorption of both tramadol and doxepin is mainly driven by electrostatic interaction. The studied PPs are intercalated in a monolayer arrangement within the interlayer space through a cation exchange in stoichiometric proportion with the Na(+) cations leading to adsorbed PPs amounts that match the cation exchange capacity (CEC) of Mt. Due to their hydrophobic character, additional doxepin molecules could be adsorbed by weak molecular interaction driving to an increase of the adsorbed amount beyond the CEC at low temperature (20°C). The confinement of PPs within the interlayer space of Mt confirms the use of clay minerals as potential material for the wastewater treatment as well as it drives to an amorphous or glassy state, which can find echo in biopharmaceutical applications for a controlled release of PPs.
authors.affiliation: Institut des Sciences de la Terre d'Orléans, UMR 7327, CNRS-Université d'Orléans, 1A Rue de la Férollerie, 45071 Orléans Cedex 2, France. Electronic address: thomas.thiebault@cnrs-orleans.fr.
authors.forename: Thomas
authors.initials: T
authors.lastname: Thiebault
authors.affiliation: Institut des Sciences de la Terre d'Orléans, UMR 7327, CNRS-Université d'Orléans, 1A Rue de la Férollerie, 45071 Orléans Cedex 2, France. Electronic address: regis.guegan@univ-orleans.fr.
authors.forename: Régis
authors.initials: R
authors.lastname: Guégan
authors.affiliation: Institut des Sciences de la Terre d'Orléans, UMR 7327, CNRS-Université d'Orléans, 1A Rue de la Férollerie, 45071 Orléans Cedex 2, France. Electronic address: mohammed.boussafir@univ-orleans.fr.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Boussafir
mesh_terms: D000327:Adsorption; D000701:Analgesics, Opioid / Q000302:isolation & purification*; D004316:Doxepin / Q000302:isolation & purification*; D017640:Silicates / Q000737:chemistry*; D000068776:Sleep Aids, Pharmaceutical / Q000302:isolation & purification*; D017550:Spectroscopy, Fourier Transform Infrared; D014147:Tramadol / Q000302:isolation & purification*; D014867:Water / Q000032:analysis; D014874:Water Pollutants, Chemical / Q000302:isolation & purification*; D014961:X-Ray Diffraction
chemical_list: D000701:Analgesics, Opioid; D017640:Silicates; D000068776:Sleep Aids, Pharmaceutical; D014874:Water Pollutants, Chemical; D014867:Water; D004316:Doxepin; D014147:Tramadol; C033214:Smectite
keywords: Adsorption; Amorphous systems; Clay mineral; Pharmaceutical products