title: Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance.
abstract: A new generation of photothermal theranostic agents based on assembling 6 nm gold nanoparticles (AuNPs) is developed by using a novel comb-like amphipathic polymer as the template. The small AuNPs are assembled into DOX@gold nanomicelles, which show strong absorbance in the near-infrared region, for multimodal bioimaging and highly effective in vivo chemotherapy and photothermal therapy.
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China.|School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049, PR China.
authors.forename: Heng
authors.initials: H
authors.lastname: Deng
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China.
authors.forename: Fengying
authors.initials: F
authors.lastname: Dai
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Ma
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use / Q000633:toxicity; D002470:Cell Survival; D005240:Feasibility Studies; D005347:Fibroblasts / Q000502:physiology; D017612:Gold Compounds / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053685:Laser Therapy / Q000295:instrumentation; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000627:therapeutic use / Q000633:toxicity; D008689:Methacrylates / Q000633:toxicity; D051379:Mice; D008823:Micelles; D064847:Multimodal Imaging / Q000295:instrumentation; D009368:Neoplasm Transplantation; D010789:Phototherapy / Q000295:instrumentation; D011102:Polyhydroxyethyl Methacrylate / Q000633:toxicity; D011108:Polymers / Q000627:therapeutic use / Q000633:toxicity; D000068936:Theranostic Nanomedicine / Q000295:instrumentation; D014471:Umbilical Veins / Q000166:cytology / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D017612:Gold Compounds; D008689:Methacrylates; D008823:Micelles; D011108:Polymers; C581192:poly(2-(2-methoxyethoxy)ethyl methacrylate); D011102:Polyhydroxyethyl Methacrylate
keywords: clearance; comb-like polymers; gold nanoparticles; self-assembly; theranostics