title: Association between the MARS rs6782181 polymorphism and serum lipid levels.
abstract: Little is known about the association between the muscle Ras (MRAS) gene rs6782181 polymorphism and serum lipid levels. The aim of the present study was to investigate the association between the MRAS rs6782181 polymorphism and serum lipid levels in the Mulao and Han populations. A total of 632 subjects of Han and 629 unrelated subjects of Mulao nationalities were randomly selected from our previous stratified randomized samples. Genotypes of the MARS rs6782181 polymorphism were determined via polymerase chain reaction and restriction fragment length polymorphism. The subjects with GG genotype had higher serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein (Apo) B levels in Han, and higher serum TC and LDL-C levels in Mulao than the subjects with AA/AG genotypes (P < 0.05-0.01). Subgroup analyses showed that the subjects with GG genotype had higher TC, TG, high-density lipoprotein cholesterol (HDL-C), LDL-C, ApoAI and ApoB in Han males, lower ApoAI and the ratio of ApoAI to ApoB in Han females; and higher LDL-C levels in Mulao males but not in Mulao females than the subjects with AG/AA genotypes. The association of the MARS rs6782181 polymorphism and serum lipid levels is different between the Mulao and Han populations, or between males and females in the both ethnic groups. There may be an ethnic- and/or sex-specific association between the MRAS rs6782181 polymorphism and serum lipid levels in our study populations.
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Rui-Xing
authors.initials: RX
authors.lastname: Yin
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Quan-Zhen
authors.initials: QZ
authors.lastname: Lin
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Guang-Yuan
authors.initials: GY
authors.lastname: Shi
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Jia-Qi
authors.initials: JQ
authors.lastname: Sun
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Shao-Wen
authors.initials: SW
authors.lastname: Shen
authors.affiliation: Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Wang
authors.affiliation: Clinical Laboratory of The Affiliated Cancer Hospital, Guangxi Medical University Nanning 530021, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University 22 Shuangyong Road, Nanning 530021, Guangxi, People's Republic of China.
authors.forename: Jin-Zhen
authors.initials: JZ
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D050171:Dyslipidemias / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012737:Sex Factors; D018631:ras Proteins / Q000235:genetics*
chemical_list: D015415:Biomarkers; D008055:Lipids; C109523:MRAS protein, human; D018631:ras Proteins
keywords: 3q22.3; MRAS; Muscle Ras; rs6782181; serum lipid level; single nucleotide polymorphism