title: Effect of drying methods on physicochemical properties and antioxidant activities of wolfberry (Lycium barbarum) polysaccharide.
abstract: In this study, an efficient drying process of Lycium barbarum L. polysaccharide (LBP) suitable for industrial production was developed and optimized. Three drying methods, including hot air drying (40-80°C), vacuum drying (40-60°C) and spray drying were test and compared. Hot air drying and vacuum drying cost long time and produced a brown product which needs further process due to the agglomeration or alveolation form. The condition of spray drying (without any excipient) was optimized by orthogonal experiment, which gave different optimum conditions based on LBP recovery rate (LBP solution concentration 1.06 g/mL, inlet air temperature 170°C, sample flow rate 15 mL/min and air speed 4.2m(3)/min) or LBP transparency (LBP solution concentration 1.04 g/mL, inlet air temperature 170°C, sample flow rate 20 mL/min and air speed 2.8m(3)/min). Pilot scale experiments showed preferable stability of LBP product quality and process parameters. Sample of spray drying (SD) had the highest scavenging free radical effects, the best appearance (LBP transparency), and uniform morphology with hollow sphere which are important properties for the reconstitution of the powder product. Considering the product appearance and product activity, the spray drying was selected to apply in industrial production.
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190 Beijing, PR China.
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190 Beijing, PR China; Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Beitao
authors.initials: B
authors.lastname: Dong
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190 Beijing, PR China; Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China.
authors.forename: Jinjin
authors.initials: J
authors.lastname: Chen
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190 Beijing, PR China. Electronic address: bzhao@ipe.ac.cn.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhao
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190 Beijing, PR China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Wang
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190 Beijing, PR China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Wang
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190 Beijing, PR China; Graduate University of Chinese Academy of Sciences, Beijing 100049, PR China; Beijing Tong Ren Tang Health Pharmaceutical Co., Ltd., Beijing 100085, PR China.
authors.forename: Shenghua
authors.initials: S
authors.lastname: Zha
authors.affiliation: National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 100190 Beijing, PR China.
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Yinchuan Taifeng Biotechnology Co., Ltd., Yinchun 750200, PR China.
authors.forename: Jinhong
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Yinchuan Taifeng Biotechnology Co., Ltd., Yinchun 750200, PR China.
authors.forename: Yuling
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D003890:Desiccation / Q000379:methods*; D006358:Hot Temperature; D032305:Lycium / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology; D014618:Vacuum
chemical_list: D000975:Antioxidants; D011134:Polysaccharides
keywords: Antioxidant activity; Drying process; Lycium barbarum L.; Polysaccharide