title: High Oral Human Papillomavirus Type 16 Load Predicts Long-term Persistence in Individuals With or at Risk for HIV Infection.
abstract: The association between oral human papillomavirus 16 (HPV16) DNA load and infection clearance was evaluated among 88 individuals with oral HPV16 infection who were identified within a prospective cohort of 1470 HIV-infected and uninfected individuals. Oral rinse specimens were collected semiannually for up to 5 years. The oral HPV16 load at the time of the first positive test result was significantly associated with the time to clearance of infection (continuous P trends <.01). Notably, clearance rates by 24 months were 41% and 94% in the highest and lowest HPV16 load tertiles (P = .03), respectively. High oral HPV16 load warrants consideration as a biomarker for infection persistence, the presumed precursor of HPV16-associated oropharyngeal cancer.
authors.affiliation: Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Beachler
authors.affiliation: Viral Oncology Program, Ohio State University Comprehensive Cancer Center, Columbus.
authors.forename: Yingshi
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Viral Oncology Program, Ohio State University Comprehensive Cancer Center, Columbus.
authors.forename: Wiehong
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Pediatrics Department of Microbiology and Immunology Department of Obstetrics, Gynecology, and Women's Health.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Burk
authors.affiliation: Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York.
authors.forename: Howard
authors.initials: H
authors.lastname: Minkoff
authors.affiliation: Department of Epidemiology Department of Population Health, Albert Einstein College of Medicine, Bronx.
authors.forename: Howard D
authors.initials: HD
authors.lastname: Strickler
authors.affiliation: Department of Medicine, University of Pittsburgh, Pennsylvania.
authors.forename: Ross D
authors.initials: RD
authors.lastname: Cranston
authors.affiliation: School of Nursing, University of California-Los Angeles.
authors.forename: Dorothy J
authors.initials: DJ
authors.lastname: Wiley
authors.affiliation: Department of Epidemiology.
authors.forename: Lisa P
authors.initials: LP
authors.lastname: Jacobson
authors.affiliation: Hektoen Institute of Medicine, The CORE Center at John H. Stroger Jr. Hospital of Cook County.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Weber
authors.affiliation: Viral Oncology Program, Ohio State University Comprehensive Cancer Center, Columbus.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Margolick
authors.affiliation: Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Sugar
authors.affiliation: Department of Infectious Disease, Northwestern University, Chicago, Illinois.
authors.forename: Susheel
authors.initials: S
authors.lastname: Reddy
authors.affiliation: Viral Oncology Program, Ohio State University Comprehensive Cancer Center, Columbus.
authors.forename: Maura L
authors.initials: ML
authors.lastname: Gillison
authors.affiliation: Department of Epidemiology.
authors.forename: Gypsyamber
authors.initials: G
authors.lastname: D'Souza
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000821:virology*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D011446:Prospective Studies; D013997:Time Factors; D019562:Viral Load
keywords: HIV; oral HPV; oropharyngeal cancer; persistence; viral load