title: The development of membranous lupus nephritis during treatment with mycophenolate mofetil for proliferative renal disease.
abstract: The transformation of lupus nephritis from one histologic pattern to another is well described. We report a case of a patient who initially presented with diffuse proliferative glomerulonephritis and was treated with prednisone and mycophenolate mofetil (MMF). She initially responded well to therapy, but later developed high-grade proteinuria while still on MMF and low-dose steroids. A repeat biopsy performed after the increase in proteinuria demonstrated that she had focal proliferative disease but that she had also developed membranous lupus nephritis. Our case is unique in that we report a patient who developed membranous lupus nephritis while receiving MMF.
authors.affiliation: Department of Medicine, School of Medicine , University of Colorado Denver , Denver, CO , USA.
authors.forename: Kristen
authors.initials: K
authors.lastname: Dalton
authors.affiliation: Departments of Pathology and Medicine, School of Medicine , University of Colorado Denver , Aurora, CO , USA.
authors.forename: Maxwell
authors.initials: M
authors.lastname: Smith
authors.affiliation: Department of Medicine, School of Medicine , University of Colorado Denver , Denver, CO , USA.
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Thurman
keywords: membranous lupus nephritis; mycophenolate mofetil; transformation