title: Circulating Tumour Cells in Patients with Malignant Lung Tumors Undergoing Radio-frequency Ablation.
abstract: OBJECTIVE
  Radiofrequency ablation (RFA) is an increasingly utilised technique in patients with surgically-untreatable lesions. The effect of this therapy on circulating tumor cells (CTCs) is unknown. As far as we are aware of, this is the first study to evaluate the effects of RFA on CTCs in patients with malignant lung tumors immediately post-treatment.
  
  
  METHODS
  Nine patients with primary or metastatic lung tumors underwent RFA therapy from June to November 2013. Blood samples were taken before and after RFA, and filtered through the ScreenCell CTC capture device.
  
  
  RESULTS
  A general increase in CTCs in 7 out of the 9 cases was found, the largest increases were seen in the metastatic group.
  
  
  CONCLUSIONS
  This study demonstrates that the manipulation and ablative procedure of lung tumors leads to immediate dissemination of tumor cells, the effects of which are unknown and require further investigation.
authors.affiliation: Departments of Thoracic Radiology and Thoracic Surgery, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, Harefield, Middlesex, U.K.
authors.forename: Dimple
authors.initials: D
authors.lastname: Chudasama
authors.affiliation: Departments of Thoracic Radiology and Thoracic Surgery, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, Harefield, Middlesex, U.K.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Rice
authors.affiliation: Departments of Thoracic Radiology and Thoracic Surgery, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, Harefield, Middlesex, U.K.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Anikin
authors.affiliation: Departments of Thoracic Radiology and Thoracic Surgery, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, Harefield, Middlesex, U.K.
authors.forename: Gopal
authors.initials: G
authors.lastname: Soppa
authors.affiliation: Departments of Thoracic Radiology and Thoracic Surgery, Harefield Hospital, The Royal Brompton and Harefield Hospital NHS Foundation Trust, Harefield, Middlesex, U.K. p.dalal@rbht.nhs.uk.
authors.forename: Paras
authors.initials: P
authors.lastname: Dalal
mesh_terms: D000368:Aged; D017115:Catheter Ablation / Q000009:adverse effects; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009360:Neoplastic Cells, Circulating / Q000528:radiation effects*; D016896:Treatment Outcome
keywords: Circulating tumor cells; ScreenCell; ablative; radiofrequency ablation