title: Arrhythmogenic right ventricular cardiomyopathy coincided with the cardiac fibrosis in the inner muscle layer of the left ventricular wall in a boxer dog.
abstract: A 7-year-old female boxer dog died suddenly without any clinical signs. It was suspected that the dog had arrhythmogenic right ventricular cardiomyopathy (ARVC) due to ventricular premature complexes and ventricular tachycardia at 3 years of age. The final diagnosis of ARVC was confirmed by histological characteristics, such as loss of cardiocytes and fibrofatty replacement, occurring in the right and left ventricular walls. In the cardiocytes, non-lipid vacuoles were observed. Cardiac fibrosis and intimal thickening of the small arteries occurred without fatty replacement in the inner muscle layer including the papillary muscles of the left ventricular wall. This paper describes the pathomorphological details of an ARVC case with coincidental cardiac fibrosis in the inner muscle layer of the left ventricular wall.
authors.affiliation: Pathology Department, Kashima Laboratory, Nonclinical Research Center, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan.
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yamada
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitamori
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Kitamori
authors.forename: Kanako
authors.initials: K
authors.lastname: Ishigami
authors.forename: Koji
authors.initials: K
authors.lastname: Iwanaga
authors.forename: Taiki
authors.initials: T
authors.lastname: Itou
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Shino
authors.initials: S
authors.lastname: Kumabe
authors.forename: Takuya
authors.initials: T
authors.lastname: Doi
authors.forename: Junko
authors.initials: J
authors.lastname: Sato
authors.forename: Yumi
authors.initials: Y
authors.lastname: Wako
authors.forename: Minoru
authors.initials: M
authors.lastname: Tsuchitani
mesh_terms: D000818:Animals; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000473:pathology / Q000662:veterinary*; D003645:Death, Sudden / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D005355:Fibrosis / Q000473:pathology / Q000662:veterinary*; D006352:Heart Ventricles / Q000473:pathology*