title: Pre-clinical In Vitro and In Vivo Models for Heart Valve Therapies.
abstract: Heart valve disease is a frequently encountered pathology, related to high morbidity and mortality rates. Animal models are interesting to investigate the causality but also underlying mechanisms and potential treatments of human heart valve diseases. Strongly believing that both in vivo and ex vivo models are fundamental to support research and development of new technologies, we here report some examples of heart valve disease models, which in our experience have been actively used to support the development of new valve therapies.
authors.affiliation: Department of Cardiovascular Surgery, University Hospital of Zürich, Zürich, Switzerland.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Taramasso
authors.forename: Maximilian Y
authors.initials: MY
authors.lastname: Emmert
authors.forename: Diana
authors.initials: D
authors.lastname: Reser
authors.forename: Andrea
authors.initials: A
authors.lastname: Guidotti
authors.forename: Nikola
authors.initials: N
authors.lastname: Cesarovic
authors.forename: Marino
authors.initials: M
authors.lastname: Campagnol
authors.forename: Alessandro
authors.initials: A
authors.lastname: Addis
authors.forename: Fabian
authors.initials: F
authors.lastname: Nietlispach
authors.forename: Simon P
authors.initials: SP
authors.lastname: Hoerstrup
authors.forename: Francesco
authors.initials: F
authors.lastname: Maisano
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization; D006349:Heart Valve Diseases / Q000628:therapy*; D006351:Heart Valves / Q000637:transplantation; D008954:Models, Biological; D008955:Models, Cardiovascular; D012756:Sheep; D013552:Swine; D023822:Tissue Engineering