title: ¹⁸F-FDG-PET/CT Imaging in Patients with Febrile Neutropenia and Haematological Malignancies.
abstract: The aim of the present study was to assess the prevalence of hyper-metabolic infection sites revealed by fluorine-18 ((18)F) fluorodeoxyglucose (FDG) positron-emission tomography (PET) combined with computed tomography (CT) in patients with febrile neutropenia (FN). Forty-eight consecutive patients with haematological malignancies and persistent FN (temperature ≥ 38°C and neutrophil count <500 cells/μl for more than two days) as a consequence of intensive chemotherapy were prospectively included. Pathological FDG uptakes identified 31 foci of infections located in the lungs (n=15, 48.4 %), colon (n=4, 12.9%), pancreas (n=2, 6.5%), skin (n=3, 9.7%), ear-nose-throat area (n=5, 16.1%), central venous catheter tract (n=1, 3.2%) and gallbladder (n=1, 3.2%). These pathological FDG uptakes were observed in half of the 48 patients (n=24). Among the 38 patients with a clinical diagnosis of infection, 23 showed a pathological FDG uptake, resulting in a FDG-PET/CT sensitivity of 61% (95% CI, 43-76%). Our study confirmed the ability of FDG-PET/CT to diagnose infections in patients with persistent FN.
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Camus
authors.affiliation: Nuclear Medicine, QuantIF, Centre Henri Becquerel, Rouen, France.
authors.forename: Agathe
authors.initials: A
authors.lastname: Edet-Sanson
authors.affiliation: Department of Biostatistics, University Hospital of Rouen, Rouen, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Bubenheim
authors.affiliation: Department of Nuclear Medicine, Purpan University Hospital, Toulouse, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Hitzel
authors.affiliation: Nuclear Medicine, QuantIF, Centre Henri Becquerel, Rouen, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Becker
authors.affiliation: Department of Biology; Centre Henri Becquerel, Rouen, France.
authors.forename: Marion
authors.initials: M
authors.lastname: David
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France.
authors.forename: Aspasia
authors.initials: A
authors.lastname: Stamatoullas
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Lenain
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Jardin
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Contentin
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France.
authors.forename: Marie Laure
authors.initials: ML
authors.lastname: Fontoura
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Cardinael
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Vaudaux
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France.
authors.forename: Sydney
authors.initials: S
authors.lastname: Dubois
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Tilly
authors.affiliation: Nuclear Medicine, QuantIF, Centre Henri Becquerel, Rouen, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Vera
authors.affiliation: Department of Haematology, Centre Henri Becquerel, Rouen, France stephane.lepretre@chb.unicancer.fr.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Leprêtre
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003952:Diagnostic Imaging; D064147:Febrile Neutropenia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D019337:Hematologic Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007239:Infections / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: 18F-FDG-PET/CT; febrile neutropenia; haematological malignancies; invasive aspergillosis