title: Characterization of clinical and genetic risk factors associated with dyslipidemia after kidney transplantation.
abstract: We determined the prevalence of dyslipidemia in a Japanese cohort of renal allograft recipients and investigated clinical and genetic characteristics associated with having the disease. In total, 126 patients that received renal allograft transplants between February 2002 and August 2011 were studied, of which 44 recipients (34.9%) were diagnosed with dyslipidemia at 1 year after transplantation. Three clinical factors were associated with a risk of having dyslipidemia: a higher prevalence of disease observed among female than male patients (P = 0.021) and treatment with high mycophenolate mofetil (P = 0.012) and prednisolone (P = 0.023) doses per body weight at 28 days after transplantation. The genetic association between dyslipidemia and 60 previously described genetic polymorphisms in 38 putative disease-associated genes was analyzed. The frequency of dyslipidemia was significantly higher in patients with the glucocorticoid receptor (NR3C1) Bcl1 G allele than in those with the CC genotype (P = 0.001). A multivariate analysis revealed that the NR3C1 Bcl1 G allele was a significant risk factor for the prevalence of dyslipidemia (odds ratio = 4.6; 95% confidence interval = 1.8-12.2). These findings may aid in predicting a patient's risk of developing dyslipidemia.
authors.affiliation: Department of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Numakura
authors.affiliation: Department of Pharmacy, Akita University Hospital, Akita 010-8543, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kagaya
authors.affiliation: Department of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yamamoto
authors.affiliation: Department of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Komine
authors.affiliation: Department of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Saito
authors.affiliation: Department of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Tsuruta
authors.initials: T
authors.lastname: Hiroshi
authors.affiliation: Department of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Akihama
authors.affiliation: Department of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Takamitsu
authors.identifier: 0000-0002-1362-4344
authors.initials: T
authors.lastname: Inoue
authors.affiliation: Department of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Narita
authors.affiliation: Department of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Tsuchiya
authors.affiliation: Department of Urology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Habuchi
authors.affiliation: Department of Pharmacy, Akita University Hospital, Akita 010-8543, Japan.
authors.forename: Takenori
authors.initials: T
authors.lastname: Niioka
authors.affiliation: Department of Pharmacy, Akita University Hospital, Akita 010-8543, Japan.
authors.forename: Masatomo
authors.initials: M
authors.lastname: Miura
authors.affiliation: Center for Kidney Disease and Transplantation, Akita University Hospital, Akita 010-8543, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Satoh
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D050171:Dyslipidemias / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D020641:Polymorphism, Single Nucleotide; D011239:Prednisolone / Q000009:adverse effects; D015995:Prevalence; D011965:Receptors, Glucocorticoid / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D007166:Immunosuppressive Agents; C497713:NR3C1 protein, human; D011965:Receptors, Glucocorticoid; D011239:Prednisolone; D009173:Mycophenolic Acid