title: The relationship between cytotoxin-associated gene A positive Helicobacter pylori infection and autoimmune thyroid disease.
abstract: OBJECTIVE
  The aim of this study was to determine whether there is an association between cagA [cytotoxin-associated gene A] positivity and thyroid autoimmunity and thyroid volume.
  
  
  METHODS
  This prospective study included 78 Helicobacter pylori-positive (H. pylori) dyspeptic patients in the study group, and 50 age-, gender-, and body mass index-matched H. pylori-negative dyspeptic patients in the control group. All the controls were evaluated via upper gastrointestinal endoscopic biopsy or breath test, and were found as H. pylori negative. Gastric biopsy specimens were obtained via endoscopy and histological examination was performed for documentation of H. pylori.
  
  
  RESULTS
  In all, 55.1% (n = 43) of the H. pylori-positive patients were cagA positive. There was no significant difference in metabolic syndrome parameters or thyroid function test results between the study and control groups. The frequency of anti-TPO and Hashimoto's thyroiditis positivity was significantly higher in the study group than in the control group. Thyroid volume was higher and severe parenchymal heterogeneity was more common in the H. pylori-positive patients.
  
  
  CONCLUSIONS
  H. pylori infection might be a risk factor for autoimmune thyroid disease and high thyroid volume in patients diagnosed with histological evaluation. However, cagA positivity has no additional effect on these parameters.
authors.affiliation: a Department of Endocrinology and Metabolic Diseases and.
authors.forename: Muyesser Sayki
authors.initials: MS
authors.lastname: Arslan
authors.affiliation: b Department of Gastroenterology , Diskapi Yildirim Beyazit Training and Research Hospital , Ankara , Turkey .
authors.forename: Fuat
authors.initials: F
authors.lastname: Ekiz
authors.affiliation: b Department of Gastroenterology , Diskapi Yildirim Beyazit Training and Research Hospital , Ankara , Turkey .
authors.forename: Murat
authors.initials: M
authors.lastname: Deveci
authors.affiliation: c Department of Endocrinology and Metabolism , School of Medicine, Ankara University , Ankara , Turkey , and.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Sahin
authors.affiliation: a Department of Endocrinology and Metabolic Diseases and.
authors.forename: Oya
authors.initials: O
authors.lastname: Topaloglu
authors.affiliation: a Department of Endocrinology and Metabolic Diseases and.
authors.forename: Basak
authors.initials: B
authors.lastname: Karbek
authors.affiliation: a Department of Endocrinology and Metabolic Diseases and.
authors.forename: Esra
authors.initials: E
authors.lastname: Tutal
authors.affiliation: d Department of Clinical Biochemistry , Diskapi Yildirim Beyazit Training and Research Hospital , Ankara , Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ginis
authors.affiliation: a Department of Endocrinology and Metabolic Diseases and.
authors.forename: Erman
authors.initials: E
authors.lastname: Cakal
authors.affiliation: a Department of Endocrinology and Metabolic Diseases and.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozbek
authors.affiliation: b Department of Gastroenterology , Diskapi Yildirim Beyazit Training and Research Hospital , Ankara , Turkey .
authors.forename: Osman
authors.initials: O
authors.lastname: Yuksel
authors.affiliation: a Department of Endocrinology and Metabolic Diseases and.
authors.forename: Tuncay
authors.initials: T
authors.lastname: Delibasi
mesh_terms: D000328:Adult; D000942:Antigens, Bacterial / Q000097:blood*; D001426:Bacterial Proteins / Q000097:blood*; D004415:Dyspepsia / Q000097:blood*; D005260:Female; D050031:Hashimoto Disease / Q000097:blood* / Q000000981:diagnostic imaging; D016481:Helicobacter Infections / Q000097:blood*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori
keywords: Helicobacter pylori; cytotoxin-associated gene A; thyroid function test