title: Fistulains A and B, New Bischromones from the Bark of Cassia fistula, and Their Activities.
abstract: Fistulains A and B (1 and 2), two novel bischromones with unique coupling patterns, alone with their biosynthetic related compound 3, were isolated from the bark of Cassia fistula. Fistulain A represents a new type of dimeric chromone alkaloid biogenetically derived from a chromone and a tricyclic alkaloid through an unusual C-14-N linkage. Fistulain B has a new carbon skeleton with a C-14-C-5' linkage formed between two different chromone units. Fistulain A displayed anti-TMV activity, and both 1 and 2 showed weak cytotoxicities.
authors.affiliation: †Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, Yunnan, People's Republic of China.|‡Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, Yunnan, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Zhou
authors.affiliation: †Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, Yunnan, People's Republic of China.
authors.forename: Kun
authors.initials: K
authors.lastname: Zhou
authors.affiliation: †Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, Yunnan, People's Republic of China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Gao
authors.affiliation: †Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, Yunnan, People's Republic of China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Jiang
authors.affiliation: ∥Chemistry and Chemical Engineering College, Chongqing University, Chongqing 400030, People's Republic of China.
authors.forename: Jun-Jiang
authors.initials: JJ
authors.lastname: Lv
authors.affiliation: ‡Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, Yunnan, People's Republic of China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: ‡Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, Yunnan, People's Republic of China.
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Yang
authors.affiliation: ‡Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650231, Yunnan, People's Republic of China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Miao
authors.affiliation: §Department of Medicinal Chemistry and Pharmacognosy and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
authors.forename: Chun-Tao
authors.initials: CT
authors.lastname: Che
authors.affiliation: †Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650031, Yunnan, People's Republic of China.|§Department of Medicinal Chemistry and Pharmacognosy and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Hu
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002366:Cassia / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D002867:Chromones; C000601933:fistulain A; C000601934:fistulain B