title: Eosinophilia à deux: a brain nagging souvenir from the Philippines.
abstract: Angiostrongylus cantonensis is the most common cause of eosinophilic meningitis. Although a rare condition among travelers, increased travel and global transportation of food products may result in more cases across non-endemic, developed countries in the future. We here describe two men with headache and painful skin after visiting the Philippines as presenting symptoms. Subsequently, confusion and focal neurologic symptoms developed. Both had increased serum eosinophils; however, CSF eosinophilia was only demonstrated after repeated lumbar puncture. In the CSF of both, Angiostrongylus spp. DNA was detected. Both were treated with albendazole combined with corticosteroids, after which symptoms improved.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Center for Tropical and Travel Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1100 AZ, Amsterdam, The Netherlands. a.j.lammers@amc.uva.nl.
authors.forename: A J J
authors.initials: AJ
authors.lastname: Lammers
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Center for Tropical and Travel Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1100 AZ, Amsterdam, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Goorhuis
authors.affiliation: Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: van de Beek
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Center for Tropical and Travel Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1100 AZ, Amsterdam, The Netherlands.
authors.forename: M P
authors.initials: MP
authors.lastname: Grobusch
authors.affiliation: Department of Parasitology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Bart
authors.affiliation: Department of Parasitology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: van Gool
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Center for Tropical and Travel Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1100 AZ, Amsterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: van Vugt
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D015766:Albendazole / Q000627:therapeutic use; D017185:Angiostrongylus cantonensis / Q000302:isolation & purification*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000469:parasitology; D018509:DNA, Helminth / Q000134:cerebrospinal fluid / Q000302:isolation & purification*; D004802:Eosinophilia / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008581:Meningitis / Q000150:complications / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D010679:Philippines; D017206:Strongylida Infections / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D014195:Travel; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000871:Anthelmintics; D000893:Anti-Inflammatory Agents; D018509:DNA, Helminth; D015766:Albendazole