title: The hemorrhage risk of prophylactic external ventricular drain insertion in aneurysmal subarachnoid hemorrhage patients requiring endovascular aneurysm treatment: a systematic review and meta-analysis.
abstract: Endovascular treatment of acutely ruptured aneurysms requires the administration of antiplatelet and/or anticoagulant medication to prevent thrombosis. For patients who require an external ventricular drain (EVD) insertion to treat hydrocephalus stemming from aneurysm subarachnoid hemorrhage (aSAH), the administration of the medication may increase risk of hemorrhage in patients. It has become a practice for neurosurgeons to insert EVDs in patients with aSAH before endovascular treatment. However, the benefits and risks of this practice have not been fully assessed. The aim of this study was to compare and quantify the hemorrhagic risks associated with endovascular treatment of patients with sSAH before and after EVD.
  
  
  
  This is a systematic review and meta-analysis. The literature was searched for studies with EVD and non-EVD patients with ruptured aneurysms undergoing endovascular treatment of aneurysms. A qualitative and quantitative assessment of EVD-related hemorrhage risk before and after endovascular treatment was undergone.
  
  
  
  There seemed to be a stronger correlation between EVD-related hemorrhage and EVD insertion after endovascular treatment (cumulative relative risk: 9.61; 95% CI: 2.29, 40.24) compared to EVD insertion before endovascular treatment (cumulative relative risk: 2.37; 95% CI: 0.57, 9.81).
  
  
  
  EVD-related hemorrhage risk may increase with administration of antiplatelet and/or anticoagulant medication for endovascular treatment of ruptured aneurysms in aSAH patients.
authors.affiliation: University of Toronto, Toronto, Canada - alicexia.zhu@mail.utoronto.ca.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D004621:Embolization, Therapeutic / Q000379:methods; D006801:Humans; D006849:Hydrocephalus / Q000188:drug therapy / Q000503:physiopathology; D002532:Intracranial Aneurysm / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors