title: Evaluation of a new hyaluronic acid dermal filler for volume restoration.
abstract: OBJECTIVE
  The present study aimed to evaluate the effectiveness and safety of hyaluronic acid gel for the treatment of volume loss or contour deficiency.
  
  
  METHODS
  This 6-month, open-label study recruited sixty adults aged 40-65 years with bilateral moderate to severe volume loss or contour deficiency (Facial Volume Loss Scale [FVLS] score: 2-5). Eligible subjects were treated at the baseline visit with an injection of hyaluronic acid gel in one or more of three facial subregions: the zygomatic malar region, the anteromedial cheek and nasolabial folds.
  
  
  RESULTS
  A significant improvement from baseline was observed in the FVLS score at each study visit up to 6 months post treatment (p < 0.0125 by Wilcoxon test). A significant improvement was also observed in the Global Aesthetic Improvement Scale (GAIS) at each visit up to 6 months. The study showed that the GAIS score improved in 100% of subjects at month 3, while at the end of the study (month 6) the percentage of improved subjects decreased to 91. Treatment effect was maintained by 100% of subjects up to month 3, while 57% of subjects showed a persistence of effect up to month 6.
  
  
  CONCLUSIONS
  Volume loss or contour deficiency may be safely and effectively corrected using the new dermal filler.
authors.affiliation: a Clinical Professor of International Foundation Fatebenefratelli Rome, School of Aesthetic Medicine; Private Practice, Aesthetic Medicine , Rome , Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Alessandrini
authors.affiliation: b Department of Plastic , Reconstructive and Aesthetic Surgery, 'Sapienza' University , Policlinico 'Umberto I', Rome , Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Fino
authors.affiliation: c Department of Clinical Research , Fidia Farmaceutici , Abano Terme, Padua , Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Giordan
authors.affiliation: b Department of Plastic , Reconstructive and Aesthetic Surgery, 'Sapienza' University , Policlinico 'Umberto I', Rome , Italy.
authors.forename: Vittoria
authors.initials: V
authors.lastname: Amorosi
authors.affiliation: b Department of Plastic , Reconstructive and Aesthetic Surgery, 'Sapienza' University , Policlinico 'Umberto I', Rome , Italy.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Scuderi
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques; D000067548:Dermal Fillers; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008875:Middle Aged; D017060:Patient Satisfaction; D011446:Prospective Studies; D055675:Viscosupplements / Q000627:therapeutic use*
chemical_list: D000067548:Dermal Fillers; D055675:Viscosupplements; D006820:Hyaluronic Acid
keywords: facial defects; hyaluronic acid; new dermal filler; patient satisfaction; volume loss