title: The pleiotropic effect of physical exercise on mitochondrial dynamics in aging skeletal muscle.
abstract: Decline in human muscle mass and strength (sarcopenia) is one of the principal hallmarks of the aging process. Regular physical exercise and training programs are certain powerful stimuli to attenuate the physiological skeletal muscle alterations occurring during aging and contribute to promote health and well-being. Although the series of events that led to these muscle adaptations are poorly understood, the mechanisms that regulate these processes involve the "quality" of skeletal muscle mitochondria. Aerobic/endurance exercise helps to maintain and improve cardiovascular fitness and respiratory function, whereas strength/resistance-exercise programs increase muscle strength, power development, and function. Due to the different effect of both exercises in improving mitochondrial content and quality, in terms of biogenesis, dynamics, turnover, and genotype, combined physical activity programs should be individually prescribed to maximize the antiaging effects of exercise.
authors.affiliation: Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Via A. Saffi 2, 61029 Urbino, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Barbieri
authors.affiliation: Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Via A. Saffi 2, 61029 Urbino, Italy.
authors.forename: Deborah
authors.initials: D
authors.lastname: Agostini
authors.affiliation: Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Via A. Saffi 2, 61029 Urbino, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Polidori
authors.affiliation: Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Via A. Saffi 2, 61029 Urbino, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Potenza
authors.affiliation: Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Via A. Saffi 2, 61029 Urbino, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Guescini
authors.affiliation: Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Via A. Saffi 2, 61029 Urbino, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Lucertini
authors.affiliation: Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Via A. Saffi 2, 61029 Urbino, Italy.
authors.forename: Giosuè
authors.initials: G
authors.lastname: Annibalini
authors.affiliation: Department of Biomedicine and Prevention, University of Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Stocchi
authors.affiliation: Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Via A. Saffi 2, 61029 Urbino, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: De Santi
authors.affiliation: Department of Biomolecular Sciences, Division of Exercise and Health Sciences, University of Urbino Carlo Bo, Via A. Saffi 2, 61029 Urbino, Italy.
authors.forename: Vilberto
authors.initials: V
authors.lastname: Stocchi
mesh_terms: D000375:Aging; D004272:DNA, Mitochondrial / Q000378:metabolism; D015444:Exercise; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D063154:Mitochondrial Dynamics; D018482:Muscle, Skeletal / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D055948:Sarcopenia / Q000378:metabolism / Q000473:pathology
chemical_list: D004272:DNA, Mitochondrial; D017382:Reactive Oxygen Species