title: miR-27a promotes cell proliferation and metastasis in renal cell carcinoma.
abstract: miR-27a has been reported to exhibit abnormal expression in renal cell carcinoma (RCC), but the role of miR-27a in RCC remains unknown. In our study, up-regulation of miR-27a was validated by Real-time PCR analysis in 133 RCC samples. Overexpression of miR-27a promoted cell migration, invasion and proliferation in vitro, while its low expression exerted opposite effects. Kaplan-Meier analysis demonstrated that the patients with high expression of miR-27a had a worse overall and relapse-free survivals compared with those with low expression of miR-27a. Cox proportional hazards analyses showed that miR-27a expression was an independent prognostic factor for RCC patients. Collectively, our findings illustrate the promoting-cancer effect of miR-27a in RCC, suggesting that miR-27a could be a potential therapeutic target for RCC. Additionally, Kaplan-Meier analyses and Cox proportional regression analysis suggest that miR-27a may be a potential biomarker for predicting the survival of RCC patients.
authors.affiliation: Department of Pediatrics, Jinling Hospital, Nanjing University School of Medicine 305 Zhongshan Road East, Nanjing 210002, P.R. China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Neurology, Linyi People's Hospital No. 49 Yizhou Road, Linyi 276000, Shandong, P.R. China.
authors.forename: Xianjun
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pediatrics, Jinling Hospital, Nanjing University School of Medicine 305 Zhongshan Road East, Nanjing 210002, P.R. China.
authors.forename: Pei
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Jinling Hospital, Nanjing University School of Medicine 305 Zhongshan Road East, Nanjing 210002, P.R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.affiliation: Department of Pediatrics, Jinling Hospital, Nanjing University School of Medicine 305 Zhongshan Road East, Nanjing 210002, P.R. China.
authors.forename: Xianguo
authors.initials: X
authors.lastname: Ren
authors.affiliation: Department of Pediatrics, Jinling Hospital, Nanjing University School of Medicine 305 Zhongshan Road East, Nanjing 210002, P.R. China.
authors.forename: Zhengkun
authors.initials: Z
authors.lastname: Xia
mesh_terms: D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D015854:Up-Regulation
chemical_list: C531388:MIRN27 microRNA, human; D035683:MicroRNAs
keywords: biomarker; metastasis; miR-27a; proliferation; renal cell carcinoma