title: Near Full-Length Identification of a Novel HIV-1 CRF01_AE/B/C Recombinant in Northern Myanmar.
abstract: The Myanmar-China border appears to be the "hot spot" region for the occurrence of HIV-1 recombination. The majority of the previous analyses of HIV-1 recombination were based on partial genomic sequences, which obviously cannot reflect the reality of the genetic diversity of HIV-1 in this area well. Here, we present a near full-length characterization of a novel HIV-1 CRF01_AE/B/C recombinant isolated from a long-distance truck driver in Northern Myanmar. It is the first description of a near full-length genomic sequence in Myanmar since 2003, and might be one of the most complicated HIV-1 chimeras ever detected in Myanmar, containing four CRF01_AE, six B segments, and five C segments separated by 14 breakpoints throughout its genome. The discovery and characterization of this new CRF01_AE/B/C recombinant indicate that intersubtype recombination is ongoing in Myanmar, continuously generating new forms of HIV-1. More work based on near full-length sequence analyses is urgently needed to better understand the genetic diversity of HIV-1 in these regions.
authors.affiliation: 1 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology , Chinese Academy of Sciences, Kunming, Yunnan, China .|2 Shaanxi Engineering and Technological Research Center for Conversation and Utilization of Regional Biological Resources, College of Life Sciences, Yan'an University , Yan'an, Shaanxi, China .
authors.forename: Yan-Heng
authors.initials: YH
authors.lastname: Zhou
authors.affiliation: 1 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology , Chinese Academy of Sciences, Kunming, Yunnan, China .|3 University of the Chinese Academy of Sciences , Beijing, China .
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: 4 Yunnan International Travel Healthcare Center , Kunming, Yunnan, China .
authors.forename: Yue-Bo
authors.initials: YB
authors.lastname: Liang
authors.affiliation: 1 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology , Chinese Academy of Sciences, Kunming, Yunnan, China .
authors.forename: Wei
authors.initials: W
authors.lastname: Pang
authors.affiliation: 4 Yunnan International Travel Healthcare Center , Kunming, Yunnan, China .
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Qin
authors.affiliation: 5 Pathogen Diagnostic Center, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences , Chinese Academy of Sciences, Shanghai, China .
authors.forename: Chiyu
authors.initials: C
authors.lastname: Zhang
authors.affiliation: 1 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology , Chinese Academy of Sciences, Kunming, Yunnan, China .
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
mesh_terms: D000328:Adult; D016000:Cluster Analysis; D016679:Genome, Viral; D005838:Genotype; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D002052:Myanmar; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D012367:RNA, Viral