title: Correlation of central memory CD4+ T-Cell decrease in the peripheral blood with disease progression in SIVmac251-infected Chinese rhesus macaques.
abstract: BACKGROUND
  Correlation of CD4(+) Tcm cells in the peripheral blood to disease progression in SIVmac251 infection was examined in Chinese rhesus macaques.
  
  
  METHODS
  Plasma viral RNA loads were measured by a quantitative real-time reverse transcription-PCR (qRT-PCR) assay for SIV gag. Disease progression was determined based on time of survival. Phenotyping of CD4(+) T-cell subsets in the peripheral blood was longitudinally performed by flow cytometry.
  
  
  RESULTS
  Although CD4(+) T-cell decrease and low CD4(+)/CD8(+) T-cell ratio in the peripheral blood after SIVmac251 infection did not correlate with disease progression, CD4(+) Tcm cell decrease was observed to be correlated to disease progression in the SIVmac251-infected Chinese rhesus macaques.
  
  
  CONCLUSIONS
  Our findings suggest that CD4(+) Tcm cell decrease could be used as a predictive marker for defining the pathogenesis of the SIV disease and consequently HIV/SIV vaccine efficacy in Chinese rhesus macaques.
authors.affiliation: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Cong
authors.affiliation: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xue
authors.affiliation: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yao
authors.affiliation: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Chen
authors.affiliation: AIDS Institute, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, Beijing, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Qin
mesh_terms: D000818:Animals; D018791:CD4 Lymphocyte Count / Q000662:veterinary*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018450:Disease Progression; D007156:Immunologic Memory / Q000276:immunology*; D008253:Macaca mulatta / Q000276:immunology* / Q000821:virology; D060888:Real-Time Polymerase Chain Reaction; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D019562:Viral Load
keywords: AIDS; CD4+ Tcm cells; SIV; disease progression