title: Light Physical Activity Is Associated with Quality of Life after Colorectal Cancer.
abstract: OBJECTIVE
  Emerging evidence suggests that light physical activity (LPA), besides moderate-to-vigorous physical activity (MVPA), may beneficially influence physical functioning of colorectal cancer survivors, but its relation with other health-related outcomes is unknown. We applied a biopsychosocial approach to investigate independent associations between self-reported LPA, MVPA, and multiple health-related quality of life (HRQoL) outcomes in 2- to 10-yr postdiagnosis colorectal cancer survivors.
  
  
  METHODS
  Stage I-III colorectal cancer survivors diagnosed between 2002 and 2010 at Maastricht University Medical Center+, the Netherlands, were included in a cross-sectional study (n = 151). Time spent in LPA and MVPA (h·wk⁻¹), and HRQoL outcome scores (0-100 points) were assessed by validated questionnaires.
  
  
  RESULTS
  Median time spent in LPA and MVPA was 10.0 (interquartile range, 2.0-22.0) and 8.7 h·wk⁻¹ (4.5-15.0), respectively. In multivariable linear regression models, both LPA and MVPA were significantly and independently associated with higher physical functioning (mean difference [MD] between highest and lowest quartile, 10.2; 95% confidence interval [CI], 0.2-20.3; and 14.5; 5.1-23.9, respectively; both P-trend < 0.05). In addition, LPA was significantly associated with higher role functioning (MD, 19.5; 95% CI, 6.9-32.1; P-trend < 0.01) and lower disability (MD, -9.9; 95% CI, -17.8 to -1.9; P-trend = 0.02), independent from MVPA. Subgroup analyses showed that beneficial associations between LPA and HRQoL were mainly observed in women and participants with multiple comorbidities.
  
  
  CONCLUSIONS
  Self-reported LPA, besides MVPA, was beneficially associated with multiple HRQoL outcomes in colorectal cancer survivors, especially in women and survivors with multiple comorbidities. Prospective studies are warranted to establish whether LPA is a suitable target for personalized lifestyle interventions to improve the HRQoL of colorectal cancer survivors.
authors.affiliation: 1Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, THE NETHERLANDS; 2Department of Human Movement Science, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, THE NETHERLANDS; 3Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, THE NETHERLANDS; 4Department of Internal Medicine, Division of Gastroenterology and Hepatology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, THE NETHERLANDS; 5Department of Surgery, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, THE NETHERLANDS.
authors.forename: Eline H
authors.initials: EH
authors.lastname: Van Roekel
authors.forename: Martijn J L
authors.initials: MJ
authors.lastname: Bours
authors.forename: José J L
authors.initials: JJ
authors.lastname: Breedveld-Peters
authors.forename: Kenneth
authors.initials: K
authors.lastname: Meijer
authors.forename: Ijmert
authors.initials: I
authors.lastname: Kant
authors.forename: Piet A
authors.initials: PA
authors.lastname: Van Den Brandt
authors.forename: Silvia
authors.initials: S
authors.lastname: Sanduleanu
authors.forename: Geerard L
authors.initials: GL
authors.lastname: Beets
authors.forename: Matty P
authors.initials: MP
authors.lastname: Weijenberg
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000523:psychology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity; D011446:Prospective Studies; D011788:Quality of Life; D017741:Survivors / Q000523:psychology*; D013997:Time Factors