title: The Beauty of a Visualized Peroxo-diiron(III) Intermediate.
abstract: Deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are essential for hypusination of eukaryotic translation initiation factor 5A (eIF-5A). In this issue, Han et al. use X-ray crystallograpy and UV/Vis and Mössbauer spectroscopy to provide insights into the fundamental mechanism of the hypusination of eIF-5A and a peroxo intermediate state.
authors.affiliation: School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Republic of Singapore. Electronic address: grueber@ntu.edu.sg.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Grüber
mesh_terms: D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives*; D006899:Mixed Function Oxygenases / Q000737:chemistry* / Q000378:metabolism*; D010448:Peptide Initiation Factors / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D010448:Peptide Initiation Factors; D016601:RNA-Binding Proteins; D006899:Mixed Function Oxygenases; D008239:Lysine