title: The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review.
abstract: Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17+cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17+cells.
authors.affiliation: Department of Pathology; Leiden University Medical Center ; Leiden, The Netherlands.
authors.forename: Simone
authors.initials: S
authors.lastname: Punt
authors.affiliation: Walaeus Library; Leiden University Medical Center ; Leiden, The Netherlands.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Langenhoff
authors.affiliation: Department of Medical Statistics and Bioinformatics; Leiden University Medical Center ; Leiden, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Putter
authors.affiliation: Department of Pathology; Leiden University Medical Center ; Leiden, The Netherlands.
authors.forename: Gert Jan
authors.initials: GJ
authors.lastname: Fleuren
authors.affiliation: Department of Pathology; Leiden University Medical Center ; Leiden, The Netherlands.
authors.forename: Arko
authors.initials: A
authors.lastname: Gorter
authors.affiliation: Department of Pathology; Leiden University Medical Center ; Leiden, The Netherlands.
authors.forename: Ekaterina S
authors.initials: ES
authors.lastname: Jordanova
keywords: FFPE, formalin-fixed, paraffin-embedded; IL-17; PBMC, peripheral blood mononuclear cells; RORγ, receptor-related orphan receptor gamma; TNM, tumor node metastasis stage; Th17; cancer; survival; tumor microenvironment