title: Genetic determinants for gestational diabetes mellitus and related metabolic traits in Mexican women.
abstract: Epidemiological and physiological similarities among Gestational Diabetes Mellitus (GDM) and Type 2 Diabetes (T2D) suggest that both diseases, share a common genetic background. T2D risk variants have been associated to GDM susceptibility. However, the genetic architecture of GDM is not yet completely understood. We analyzed 176 SNPs for 115 loci previously associated to T2D, GDM and body mass index (BMI), as well as a set of 118 Ancestry Informative Markers (AIMs), in 750 pregnant Mexican women. Association with GDM was found for two of the most frequently replicated T2D loci: a TCF7L2 haplotype (CTTC: rs7901695, rs4506565, rs7903146, rs12243326; P=2.16 x 10(-06); OR=2.95) and a KCNQ1 haplotype (TTT: rs2237892, rs163184, rs2237897; P=1.98 x 10(-05); OR=0.55). In addition, we found two loci associated to glycemic traits: CENTD2 (60' OGTT glycemia: rs1552224, P=0.03727) and MTNR1B (HOMA B: rs1387153, P=0.05358). Remarkably, a major susceptibility SLC16A11 locus for T2D in Mexicans was not shown to play a role in GDM risk. The fact that two of the main T2D associated loci also contribute to the risk of developing GDM in Mexicans, confirm that both diseases share a common genetic background. However, lack of association with a Native American contribution T2D risk haplotype, SLC16A11, suggests that other genetic mechanisms may be in play for GDM.
authors.affiliation: Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, UNAM / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, D.F., Mexico City, Mexico.
authors.forename: Alicia
authors.initials: A
authors.lastname: Huerta-Chagoya
authors.affiliation: Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, UNAM / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, D.F., Mexico City, Mexico.
authors.forename: Paola
authors.initials: P
authors.lastname: Vázquez-Cárdenas
authors.affiliation: Departamento de Economía, Universidad Autónoma Metropolitana, D.F., Mexico City, Mexico.
authors.forename: Hortensia
authors.initials: H
authors.lastname: Moreno-Macías
authors.affiliation: Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, UNAM / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, D.F., Mexico City, Mexico.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Tapia-Maruri
authors.affiliation: Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, UNAM / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, D.F., Mexico City, Mexico.
authors.forename: Rosario
authors.initials: R
authors.lastname: Rodríguez-Guillén
authors.affiliation: Departamento de Ginelocología y Obstetricia, Hospital General O´Horan, Mérida, Yucatán, México.
authors.forename: Erika
authors.initials: E
authors.lastname: López-Vite
authors.affiliation: Departamento de Genética, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: García-Escalante
authors.affiliation: Departamento de Ginecología y Medicina Perinatal, Centro Médico Nacional 20 de Noviembre, D.F., Mexico City, Mexico.
authors.forename: Fernando
authors.initials: F
authors.lastname: Escobedo-Aguirre
authors.affiliation: Departamento de Endocrinología, Instituto Nacional de Perinatología, D.F., Mexico City, Mexico.
authors.forename: Adalberto
authors.initials: A
authors.lastname: Parra-Covarrubias
authors.affiliation: Departamento de Ginecología y Obstetricia, Hospital General Manuel Gea González, D.F., Mexico City, Mexico.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cordero-Brieño
authors.affiliation: Departamento de Ginecología y Obstetricia, Hospital General Manuel Gea González, D.F., Mexico City, Mexico.
authors.forename: Lizette
authors.initials: L
authors.lastname: Manzo-Carrillo
authors.affiliation: Departamento de Ginecología y Obstetricia, Hospital General Manuel Gea González, D.F., Mexico City, Mexico.
authors.forename: Rogelio
authors.initials: R
authors.lastname: Zacarías-Castillo
authors.affiliation: Departamento de Ginecología y Obstetricia, Centro de Investigación Materno Infantil GEN, D.F., Mexico City, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Vargas-García
authors.affiliation: Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salcador Zubirán, D.F., Mexico City, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Aguilar-Salinas
authors.affiliation: Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, UNAM / Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, D.F., Mexico City, Mexico.
authors.forename: Teresa
authors.initials: T
authors.lastname: Tusié-Luna
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D016640:Diabetes, Gestational / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020690:GTPase-Activating Proteins / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000235:genetics; D008800:Mexico / Q000453:epidemiology; D027501:Monocarboxylic Acid Transporters / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D044123:Receptor, Melatonin, MT2 / Q000235:genetics; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics; D055815:Young Adult
chemical_list: C446513:ARAP1 protein, human; D002352:Carrier Proteins; D020690:GTPase-Activating Proteins; D051657:KCNQ1 Potassium Channel; C573871:MTNR1B protein, human; D027501:Monocarboxylic Acid Transporters; D044123:Receptor, Melatonin, MT2; C586426:SLC16A11 protein, human; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein