title: Interaction between Erythrocyte Phospholipid Fatty Acids Composition and Variants of Inflammation-Related Genes on Type 2 Diabetes.
abstract: OBJECTIVE
  The present study aimed to investigate the interaction between erythrocyte phospholipid (PL) fatty acids and variants of inflammation-related genes in a Chinese population.
  
  
  METHODS
  A total of 622 patients with type 2 diabetes mellitus (T2DM) and 293 healthy subjects were included. Determination of erythrocyte PL fatty acids composition and genotyping of single nucleotide polymorphisms were conducted by standard methods.
  
  
  RESULTS
  A significant interaction of rs7305618 on HNFIA with C18:2n-6 and C20:4n-6 was observed: T allele carriers (TT+CT) had a higher risk of T2DM than noncarriers only when they had a higher level of C18:2n-6 or C20:4n-6, and the odds ratios (ORs) were 2.59 (95% CI 1.58-4.24; p for interaction=0.005) and 2.49 (95% CI 1.47-4.24; p for interaction=0.021), respectively. A significant interaction of rs8078723 at the intergenic region between PSMD3 and CSF3 with C20:5n-3 was observed: C allele carriers (CC+CT) had a lower risk of T2DM than noncarriers only when they had a higher level of C20:5n-3, and the OR was 0.44 (95% CI 0.26-0.73; p for interaction=0.014).
  
  
  CONCLUSIONS
  rs7305618 and rs8078723 were associated with the risk of T2DM in a Chinese population and were modulated by erythrocyte PL fatty acids composition.
authors.affiliation: Department of Food Science and Nutrition, Zhejiang University, Hangzhou, PR China.
authors.forename: Kelei
authors.initials: K
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Ju-Sheng
authors.initials: JS
authors.lastname: Zheng
authors.forename: Jianqin
authors.initials: J
authors.lastname: Sun
authors.forename: Yanqiu
authors.initials: Y
authors.lastname: Chen
authors.forename: Hua
authors.initials: H
authors.lastname: Xie
authors.forename: Danfeng
authors.initials: D
authors.lastname: Xu
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wan
authors.forename: Duo
authors.initials: D
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000235:genetics*; D004912:Erythrocytes / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D005838:Genotype; D016179:Granulocyte Colony-Stimulating Factor / Q000235:genetics; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D054647:Nutrigenomics; D010743:Phospholipids / Q000097:blood*; D020641:Polymorphism, Single Nucleotide; D046988:Proteasome Endopeptidase Complex / Q000235:genetics; D012307:Risk Factors
chemical_list: D005227:Fatty Acids; C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; D010743:Phospholipids; D016179:Granulocyte Colony-Stimulating Factor; D046988:Proteasome Endopeptidase Complex; C548045:proteasome activator PA700 subunit p58, human