title: Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability.
abstract: OBJECTIVE
  The obejctive of the present study was to investigate the potential use of floating spheroids of Atorvastatin Calcium (ATS) Loaded nanostructured lipid carriers (NLCs).
  
  
  METHODS
  The final formula of floating spheroids was optimized on the basis of shape (spherical), diameter (0.47 mm), lag time (20 s), and floating time (> 32 h).
  
  
  RESULTS
  The results were further confirmed by different pharmacokinetic parameters-it was observed that the developed optimized floating ATS spheroid-loaded NLCs formulation has significantly improved relative bioavailability, that is, 3.053-folds through oral route in comparison to marketed formulation.
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga, Punjab , India.
authors.forename: Kritika
authors.initials: K
authors.lastname: Sharma
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga, Punjab , India.
authors.forename: Supandeep Singh
authors.initials: SS
authors.lastname: Hallan
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga, Punjab , India.
authors.forename: Bharat
authors.initials: B
authors.lastname: Lal
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga, Punjab , India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Bhardwaj
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga, Punjab , India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mishra
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000069059:Atorvastatin / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D005260:Female; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004337:Drug Carriers; D000069059:Atorvastatin
keywords: floating spheroids; hyperlipidemia; nanostructured lipid carriers (NLCs); oral bioavailability