title: Polarized Light Colposcopy Compared With Standard Colposcopy.
abstract: OBJECTIVE
  The objective of this study was to determine the potential benefits of polarized light colposcopy compared with standard colposcopy examinations in the evaluation of women with abnormal cervical cytology.
  
  
  METHODS
  Polarized and standard colposcopy examinations were performed on 330 subjects. Respective images and biopsy annotations were obtained. Sensitivity and specificity; differences in the severity of cervical neoplasia; agreement of colposcopy impression, biopsy intent, and biopsy site; and differences in the number of biopsies were determined using the ROC, Bowker's test of symmetry, kappa statistic, and paired t test, respectively.
  
  
  RESULTS
  The sensitivity and specificity for a lesion being seen with nonpolarized light and polarized light colposcopy were 96.8% and 64.5%, and 96.8% and 64.9%, respectively. There was no statistically significant difference in the ROC of the lesion being seen between nonpolarized (80.7) and polarized (80.9) colposcopy. Likewise, there was no statistically significant difference in the ROC of intent to biopsy between nonpolarized (80.2) and polarized colposcopy (78.8). The agreement of cervical histopathology and colposcopy impression for nonpolarized and polarized colposcopy were 0.986 and 0.952, respectively. There was no significant difference between nonpolarized and polarized colposcopy in the mean number of lesions seen or number of sites intended to biopsy.
  
  
  CONCLUSIONS
  Polarized light colposcopy was not useful as an adjunct to conventional colposcopy in this study. Further research needs to be performed to determine the overall utility of polarized light colposcopy in clinical practice.
authors.affiliation: From the 1Department of Obstetrics and Gynecology, Georgia Regents University Cancer Center; 2Department of Biostatistics and Epidemiology, Georgia Regents University, Augusta, Georgia; and 3CerviCusco, Cusco, Peru.
authors.forename: Daron G
authors.initials: DG
authors.lastname: Ferris
authors.forename: Wendy Shulay Guevara
authors.initials: WS
authors.lastname: Condorhuaman
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Waller
authors.forename: Lynn
authors.initials: L
authors.lastname: Allmond
authors.forename: Angela
authors.initials: A
authors.lastname: Goebel
mesh_terms: D000328:Adult; D003127:Colposcopy / Q000379:methods* / Q000592:standards*; D005260:Female; D005845:Georgia; D006801:Humans; D008859:Microscopy, Polarization / Q000379:methods / Q000592:standards; D008875:Middle Aged; D010568:Peru; D012372:ROC Curve; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis / Q000473:pathology*