title: Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters.
abstract: A chiral secondary amine phosphoramide was developed and identified as a powerful catalyst for the Mukaiyama-Michael addition of fluorinated enol silyl ethers to tetrasubstituted olefins. The resulting products are obtained with high enantioselectivities and contain a quaternary carbon stereocenter bearing either a difluoroalkyl or monofluoroalkyl group.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062 (China).
authors.forename: Jin-Sheng
authors.initials: JS
authors.lastname: Yu
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062 (China).
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Liao
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062 (China).
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Gao
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062 (China).
authors.forename: Kui
authors.initials: K
authors.lastname: Liao
authors.affiliation: No 15 class of Grade 2012, Luzhou High School, 33 Zhongshan Road, Luzhou 646000 (China).
authors.forename: Run-Lin
authors.initials: RL
authors.lastname: Zuo
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062 (China). jzhou@chem.ecnu.edu.cn.|State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (P.R. China). jzhou@chem.ecnu.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
keywords: amines; asymmetric catalysis; chirality; fluorine; organocatalysis