title: Prognostic Value and Clinicopathological Differences of Bmi1 in Gastric Cancer: A Meta-analysis.
abstract: B cell-specific Moloney murine leukemia virus integration site 1 (Bmi1) was identified as a biomarker of cancer stem cells, and over-expression of Bmi1 might enhance tumor aggressive clinical behavior in gastric cancer (GC). Our aim of this meta-analysis is to investigate the prognostic role and clinicopathological differences of Bmi1 in GC patients. A total of 6 studies up to September 2014 were included in our study. Our results showed that there were no relationships between Bmi1 expression and the gender (pooled OR=0.87, 95%CI=0.66-1.14, P=0.319, fixed effect), age (pooled OR=1.22, 95%CI=0.95-1.59, P=0.126, fixed effect) and differentiation (pooled OR=1.15, 95%CI=0.71-1.86, P=0.582, random effect) in GC patients. But high Bmi1 expression was significantly correlated with the clinical stage (pooled OR=3.04, 95%CI=1.31-7.07, P=0.010, random effect), tumor size (pooled OR=2.01, 95%CI=1.14-3.55, P=0.016, random effect), T classification (pooled OR=2.79, 95%CI=1.94-4.03, P<0.001, fixed effect), lymph node metastasis (pooled OR=2.24, 95%CI=1.47-3.39, P<0.001, random effect) and distant metastasis (pooled OR=5.05, 95%CI=1.29-19.70, P=0.020, random effect), and led to a poor overall survival (OS) in GC patients (RR=3.38, 95%CI=2.43-4.69, P<0.001, fixed effect). These findings suggested that Bmi1 might serve as a novel and effective prognostic biomarker in GC, and could be a promising emerging molecular target in GC therapy.
authors.forename: Bin
authors.initials: B
authors.lastname: Yuan
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Xue
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Ye
authors.initials: Y
authors.lastname: Han
authors.forename: Lifeng
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Guo
authors.affiliation: Cancer Research Unit, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan, Canada. liz647@mail.usask.ca.
authors.forename: Qiaoming
authors.initials: Q
authors.lastname: Zhi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D063150:Polycomb Repressive Complex 1 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism*; D015996:Survival Rate
chemical_list: C069077:BMI1 protein, human; D014408:Biomarkers, Tumor; D063150:Polycomb Repressive Complex 1