title: Regulating transcription traffic around DSBs.
abstract: If a double-strand break (DSB) occurs and either a DNA polymerase or RNA polymerase is coming along, how do we save the train? In this issue of Molecular Cell, Ui et al. (2015) describe a connection between an elongation factor and a repressive complex to prevent transcription in proximity to a DSB.
authors.affiliation: Molecular Cell, Cell Press, 600 Technology Square, 5(th) Floor, Cambridge, MA 02139, USA. Electronic address: bplosky@cell.com.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Plosky
mesh_terms: D064007:Ataxia Telangiectasia Mutated Proteins / Q000378:metabolism*; D004260:DNA Repair; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism*; D063150:Polycomb Repressive Complex 1 / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D063150:Polycomb Repressive Complex 1; D064007:Ataxia Telangiectasia Mutated Proteins