title: Taurine, a major amino acid of oyster, enhances linear bone growth in a mouse model of protein malnutrition.
abstract: Oysters (Oys) contain various beneficial components, such as, antioxidants and amino acids. However, the effects of Oys or taurine (Tau), a major amino acid in Oys on bone growth have not been determined. In the present study, we evaluated the effects of Oys or Tau on linear bone growth in a mouse model of protein malnutrition. To make the protein malnutrition in a mouse, we used a low protein diet. Growth plate thickness was increased by Oys or Tau. Bone volume/tissue volume, trabecular thickness, trabecular number, connection density, and total porosity were also improved by Oys or Tau. Oys or Tau increased insulin-like growth factor-1 (IGF-1) levels in serum, liver, and tibia-growth plate. Phosphorylations of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) were increased by Oys and by Tau. These findings show that Oys or Tau may increase growth plate thickness by elevating IGF-1 levels and by promoting the phosphorylations of JAK2-STAT5, and suggest that Oys or Tau are growth-promoting substances of potential use in the food and pharmaceutical industries.
authors.affiliation: Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea.
authors.forename: Phil-Dong
authors.initials: PD
authors.lastname: Moon
authors.affiliation: Department of Computer Aided Mechanical Engineering, Sohae College, Gunsan, Jeonbuk, 573-717, Republic of Korea.
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Du Wha Com., Deokjeong-ri, Samseong-myeon, Eumseong-gun, Chungbuk, 369-833, Republic of Korea.
authors.forename: Hun-Sun
authors.initials: HS
authors.lastname: Lim
authors.affiliation: Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea.
authors.forename: Hyun-A
authors.initials: HA
authors.lastname: Oh
authors.affiliation: Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Nam
authors.affiliation: Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea.
authors.forename: Na-Ra
authors.initials: NR
authors.lastname: Han
authors.affiliation: Oriental Bio-herb Research Institute, Kangwon National University, Chuncheon, 200-701, Republic of Korea.
authors.forename: Myong-Jo
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Inflammatory Disease Research Center and Biochip Research Center, Hoseo University, 165 Sechul-ri, Baebang-myun, Asan, Chungnam, 336-795, Republic of Korea.
authors.forename: Hyun-Ja
authors.initials: HJ
authors.lastname: Jeong
authors.affiliation: Department of Pharmacology, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Republic of Korea.
authors.forename: Hyung-Min
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000235:genetics; D001846:Bone Development / Q000187:drug effects* / Q000235:genetics; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D018753:Diet, Protein-Restricted / Q000009:adverse effects*; D019587:Dietary Supplements; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D007334:Insulin-Like Growth Factor I / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D053614:Janus Kinase 2 / Q000235:genetics / Q000378:metabolism; D008297:Male; D044342:Malnutrition / Q000178:diet therapy* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D051379:Mice; D008813:Mice, Inbred ICR; D010125:Ostreidae / Q000737:chemistry; D010766:Phosphorylation; D016062:Porosity / Q000187:drug effects; D050799:STAT5 Transcription Factor / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013654:Taurine / Q000008:administration & dosage*
chemical_list: D050799:STAT5 Transcription Factor; D013654:Taurine; D007334:Insulin-Like Growth Factor I; C507926:Jak2 protein, mouse; D053614:Janus Kinase 2
keywords: IGF-1; JAK2-STAT5; growth plate; oysters; taurine