title: Relationship between abnormal NOS expression and the pathogenesis of cerebral aneurysm.
abstract: We sought to investigate the relationship between abnormal expression of nitric oxide synthase (NOS) and pathogenesis of cerebral aneurysm. Brain tissues were collected from 36 patients with cerebral aneurysm confirmed by computer tomography with angiography or neurosurgical therapy. The control group consisted of 25 patients of similar age who had no vascular diseases, as confirmed by magnetic resonance imaging. Samples of cortical arterioles were collected. The structure of the aneurysms was detected by hematoxylin and eosin staining, and the expression of inducible NOS was detected by immunohistochemistry. NOS expression was significantly higher in the patient group than in the control group (patients: 30/36 strongly positive; control: 0/25 strongly positive; P < 0.05). In conclusion, the pathogenesis underlying cerebral aneurysm may be due to abnormal expression of NOS, degradation of the extracellular matrix, aggravation of a pro-inflammatory reaction, or a deficiency in arterial elasticity layer synthesis. These changes may result in a deficiency in vascular remodeling.
authors.affiliation: Department of Neurosurgery, Qi Lu Hospital, Shandong University, Jinan, China.
authors.forename: W S
authors.initials: WS
authors.lastname: Liu
authors.affiliation: Department of Clinical Laboratory, Affiliated Hospital of Weifang Medical College, Weifang, China.
authors.forename: H J
authors.initials: HJ
authors.lastname: Geng
authors.affiliation: Centre Laboratory, Weifang People's Hospital, Shandong, China.
authors.forename: C D
authors.initials: CD
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Weifang People's Hospital, Shandong, China.
authors.forename: A J
authors.initials: AJ
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, Weifang People's Hospital, Shandong, China.
authors.forename: P C
authors.initials: PC
authors.lastname: Cao
authors.affiliation: Department of Neurosurgery, Weifang People's Hospital, Shandong, China.
authors.forename: D K
authors.initials: DK
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Qi Lu Hospital, Shandong University, Jinan, China doctorgangli88@163.com.
authors.forename: G
authors.initials: G
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D002533:Cerebral Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II / Q000096:biosynthesis / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D009569:Nitric Oxide; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II