title: Effect of Platelet-rich Fibrin on Healing of Apicomarginal Defects: A Randomized Controlled Trial.
abstract: BACKGROUND
  The purpose of this prospective, randomized controlled trial was to evaluate the healing outcomes of platelet-rich fibrin (PRF) in periapical surgeries involving apicomarginal defects and to compare these results with surgeries not using any guided tissue regeneration techniques.
  
  
  METHODS
  Thirty patients with suppurative chronic apical periodontitis and apicomarginal communication were randomly assigned to either the PRF or the control group. Clinical and radiographic parameters including pocket depth (PD), clinical attachment level, gingival marginal position, size of periapical lesion, and percentage reduction of the periapical radiolucency were recorded at baseline and at an interval of 3 months for a period of 12 months.
  
  
  RESULTS
  The overall success rate was 83.33%, with a success rate of 86.66% (13 of 15 teeth) for PRF group and 80% (12 of 15 teeth) for control group. Both the groups exhibited a significant reduction in PD, clinical attachment level, gingival marginal position, and size of periapical lesion at 12-month period. No significant differences were observed between the 2 groups for these parameters except PD, which showed a statistically significant reduction in the PRF group (P < .05).
  
  
  CONCLUSIONS
  The adjunctive use of regenerative techniques may not promote healing of apicomarginal defects of endodontic origin.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors.forename: Meenu
authors.initials: M
authors.lastname: Dhiman
authors.affiliation: Department of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors.forename: Suresh
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India. Electronic address: prashitiduhan@rediffmail.com.
authors.forename: Jigyasa
authors.initials: J
authors.lastname: Duhan
authors.affiliation: Department of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Sangwan
authors.affiliation: Department of Conservative Dentistry and Endodontics, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Tewari
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery*; D001792:Blood Platelets; D004311:Double-Blind Method; D005337:Fibrin / Q000627:therapeutic use*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D010485:Periapical Periodontitis / Q000150:complications* / Q000601:surgery*; D017622:Periodontal Attachment Loss; D011446:Prospective Studies
chemical_list: D005337:Fibrin
keywords: Apicomarginal communication; guided tissue regeneration; periradicular surgery; platelet rich fibrin; success rate