title: Atypical glandular cells of undetermined significance: implications for management in a dysplasia clinic.
abstract: OBJECTIVE
  The natural evolution of atypical glandular cells of undetermined significance (AGUS) within a dysplasia clinic population has not yet been studied. The purpose of this study was to determine the outcome of cervico-vaginal smears with the diagnosis of AGUS from dysplasia clinic patients.
  
  
  METHODS
  The cytopathological files of the Ottawa Civic Hospital were reviewed retrospectively from January 1993 to December 1995. In 59 dysplasia clinic patients, AGUS was diagnosed on one or more cervico-vaginal smears. Histological follow-up was available from 34 patients. Cytological follow-up was available on an additional 17 patients.
  
  
  RESULTS
  Nineteen patients had clinically significant lesions. In eight patients, squamous intraepithelial neoplasia was diagnosed; in five, adenocarcinoma in situ; in another five, adenocarcinoma; and, in one patient, endometrial hyperplasia with atypia. In 15 patients, follow-up was negative.
  
  
  CONCLUSIONS
  In a dysplasia clinic population in whom there was a cytological diagnosis of AGUS, we found 32% had significant pathology. Of these patients, 53% had glandular pathology. Based on our experience, histological assessment of the endocervix is suggested in these patients.
authors.affiliation: *Department of Laboratory Medicine, Ottawa Civic Hospital, Department of Pathology and Laboratory Medicine, University of Ottawa, and †Department of Gynecological Oncology, Ottawa General Hospital, Ottawa, Ontario, Canada.
authors.forename: J L
authors.initials: JL
authors.lastname: Parai
authors.forename: H M
authors.initials: HM
authors.lastname: Yazdi
authors.forename: J W
authors.initials: JW
authors.lastname: Faught