title: Improved sepsis bundles in the treatment of septic shock: a prospective clinical study.
abstract: BACKGROUND
  Sepsis bundles can decrease mortality in patients with severe sepsis or septic shock. However, current methods of measuring pressure, such as central venous pressure, are inadequate. This study investigated the effect of improved sepsis bundles informed by pulse-indicated continuous cardiac output.
  
  
  METHODS
  We compared the outcome of treatment with sepsis bundles informed by either conventional pressure measurements or pulse-indicated continuous cardiac output. Patients in 2 groups received fluid resuscitation, standard antibiotics, and oxygen therapy.
  
  
  RESULTS
  A total of 105 patients with septic shock were randomly divided into 2 groups: the conventional sepsis bundle group (n = 52) or the improved sepsis bundle group (ISBG, n =53). The ISBG significantly reduced the mean Acute Physiology and Chronic Health Evaluation II and Sepsis-related Organ Failure Assessment scores. Significantly fewer ISBG-treated patients received vasoactive drugs compared to conventional sepsis bundle group-treated patients. In addition, patients in the ISBG exhibited a significantly increased arterial blood lactate clearance rate and required less total fluid resuscitation and a shorter duration of mechanical ventilation and stay in the intensive care unit.
  
  
  CONCLUSIONS
  Pulse-indicated continuous cardiac output-directed sepsis bundles can reduce the severity of septic shock, provide more accurate fluid resuscitation, and reduce the duration of mechanical ventilation and stay in the intensive care unit.
authors.affiliation: Intensive Care Unit, Beijing Electric Power Hospital, Beijing 100073, China.
authors.forename: Nian-Fang
authors.initials: NF
authors.lastname: Lu
authors.affiliation: Intensive Care Unit, Northern Jiangsu People's Hospital, Clinical Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, China. Electronic address: zheng_rq@163.com.
authors.forename: Rui-Qiang
authors.initials: RQ
authors.lastname: Zheng
authors.affiliation: Intensive Care Unit, Northern Jiangsu People's Hospital, Clinical Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Lin
authors.affiliation: Intensive Care Unit, Northern Jiangsu People's Hospital, Clinical Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Shao
authors.affiliation: Intensive Care Unit, Northern Jiangsu People's Hospital, Clinical Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, China.
authors.forename: Jiang-Quan
authors.initials: JQ
authors.lastname: Yu
authors.affiliation: China Rehabilitation Research Center, Beijing 100068, China.
authors.forename: De-Gang
authors.initials: DG
authors.lastname: Yang
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology*; D002985:Clinical Protocols; D003422:Critical Care / Q000379:methods*; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007022:Hypotension / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D012772:Shock, Septic / Q000150:complications / Q000628:therapy*; D014883:Water-Electrolyte Imbalance / Q000150:complications / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents