title: Primary epithelioid angiosarcoma of the pleura: a case report and review of literature.
abstract: Primary angiosarcoma of the pleura is an extremely rare malignancy. Herein, we report the case of an elderly Chinese patient with primary left pleural epithelioid angiosarcoma. The 76-year-old man presented with a 4-month history of a cough with sputum expectoration and weight loss of 4 kg within one month. A chest scan showed a massive oval-shaped mass in the left pleural cavity. We then performed a left thoracotomy for tumor resection and surgical exploration. Histological examination of the resected specimen showed few viable tumor cells with significant atypia; tumor cells had large nuclei and prominent nucleoli and were arranged in a crack-like, sheeted pattern. Moreover, there was a significant amount of fibrinous exudates, hemorrhage, degeneration, and necrosis. With immunohistochemical analysis, tumor cells had strong expression of CD31, CD34, FLI-1, vimentin. Morphological and immunohistochemical findings supported the diagnosis of epithelioid angiosarcoma.
authors.affiliation: Department of Pathology, Beijing Friendship Hospital, Capital Medical University Beijing, China.
authors.forename: Shuhong
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Pathology, Beijing Friendship Hospital, Capital Medical University Beijing, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: Department of Pathology, Beijing Friendship Hospital, Capital Medical University Beijing, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Pathology, Beijing Friendship Hospital, Capital Medical University Beijing, China.
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Yu
mesh_terms: D000368:Aged; D015622:Epithelioid Cells / Q000473:pathology; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D008297:Male; D010997:Pleural Neoplasms / Q000473:pathology*
keywords: Primary angiosarcoma; immunohistochemistry; pleura