title: Synergistic effects of AKAP95, Cyclin D1, Cyclin E1, and Cx43 in the development of rectal cancer.
abstract: OBJECTIVE
  To explore the expression of A-kinase anchor protein 95 (AKAP95), Cyclin D1, Cyclin E1, and Connexin43 (Cx43) in rectal cancer tissues and assess the associations between each of the proteins and pathological parameters, as well as their inter-relationships.
  
  
  METHODS
  AKAP95, Cyclin D1, Cyclin E1, and Cx43 protein expression rates were evaluated by immunohistochemistry in 50 rectal cancer specimens and 16 pericarcinoma tissues.
  
  
  RESULTS
  The positive rates of AKAP95, Cyclin E1, and Cyclin D1 proteins were 54.00 vs. 18.75%, 62.00 vs. 6.25%, and 72.00 vs. 31.25% in rectal cancer specimens and pericarcinoma tissues, respectively, representing statistically significant differences (P < 0.05). The positive rate of Cx43 protein expression in rectal cancer tissues was 44.00% and 62.50% in pericarcinoma tissues, and the difference between them was not significant (P > 0.05). No significant associations were found between protein expression of AKAP95, Cyclin E1, Cyclin D1, and Cx43, and the degree of differentiation, histological type, and lymph node metastasis of rectal cancer (P > 0.05). However, significant correlations were obtained between the expression rates of AKAP95 and Cyclin E1, Cyclin E1 and Cyclin D1, Cyclin E1 and Cx43 protein, and Cyclin D1 and Cx43, respectively (P < 0.05).
  
  
  CONCLUSIONS
  AKAP95, Cyclin E1, and Cyclin D1 protein expression rates were significantly higher in rectal cancer tissues compared with pericarcinoma samples, suggesting an association between these proteins and the development and progression of rectal cancer. In addition, the significant correlations between the proteins (AKAP95 and Cyclin E1, Cyclin E1 and Cyclin D1, Cyclin E1 and Cx43 protein, and Cyclin D1 and Cx43) indicate the possible synergistic effects of these factors in the development and progression of rectal cancer.
authors.affiliation: Department of Pathology of Liaoning Medical College Jinzhou, China.
authors.forename: Fengjie
authors.initials: F
authors.lastname: Qi
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Yangyang
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Xuehong
authors.initials: X
authors.lastname: Zhi
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Huang
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Yuexin
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Zhuang
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Dengcheng
authors.initials: D
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Bogang
authors.initials: B
authors.lastname: Teng
authors.affiliation: Affiliated Zhongshan Hospital of Dalian University Dalian 116001, Liaoning, PR China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Kong
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen 361102, Fujian, PR China.
authors.forename: Yongxing
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D054758:A Kinase Anchor Proteins / Q000032:analysis / Q000096:biosynthesis*; D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D018031:Connexin 43 / Q000032:analysis / Q000096:biosynthesis*; D019938:Cyclin D1 / Q000032:analysis / Q000096:biosynthesis*; D019927:Cyclin E / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015513:Oncogene Proteins / Q000032:analysis / Q000096:biosynthesis*; D012004:Rectal Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D054758:A Kinase Anchor Proteins; C485099:AKAP8 protein, human; D014408:Biomarkers, Tumor; C530104:CCND1 protein, human; C475820:CCNE1 protein, human; D018031:Connexin 43; D019927:Cyclin E; D015513:Oncogene Proteins; D019938:Cyclin D1
keywords: AKAP95; Cx43; Cyclin D1; Cyclin E1; Rectal cancer