title: Interferon gamma-induced protein 10 is associated with insulin resistance and incident diabetes in patients with nonalcoholic fatty liver disease.
abstract: Nonalcoholic fatty liver disease (NAFLD) is an important risk factor for the development of type 2 diabetes mellitus. Interferon gamma-induced protein 10 (IP-10), a proinflammatory chemokine, plays a crucial role in inflammatory diseases. This cross-sectional pilot study investigated whether circulating IP-10 is associated with the progression of liver disease, and prediabetes in patients with NAFLD. A total of 90 patients with NAFLD alone (n = 48) or NAFLD with incident diabetes (n = 42) and 43 controls participated in this study. Fasting plasma was used to assess metabolic parameters, inflammatory factors, endotoxin levels, and malondialdehyde (MDA) concentrations. Insulin resistance was estimated using homeostatic model assessment (HOMA-IR). IP-10 levels were significantly higher in patients with NAFLD alone (median (interquartile range): 369.44 (309.30-418.97) pg/mL) and in those with incident diabetes (418.99 (330.73-526.04) pg/mL) than in controls (293.37 (214.10-331.57) pg/mL) (P < 0.001). IP-10 levels were positively correlated with levels of alanine aminotransferase, hs-CRP, MDA, MCP-1, and TNF-α as well as HOMA-IR values. Ordinal logistic regression analysis revealed IP-10 was an independent risk factor associated with progressive liver injury, insulin resistance and incident diabetes. Circulating IP-10 may be a non-invasive biomarker for disease progression and subsequent diabetes development of NAFLD.
authors.affiliation: 1] Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan [2] School of Medicine, Chung-Shan Medical University, Taichung, Taiwan.
authors.forename: Chia-Chu
authors.initials: CC
authors.lastname: Chang
authors.affiliation: 1] Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan [2] School of Medicine, Chung-Shan Medical University, Taichung, Taiwan [3] Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Wu
authors.affiliation: Department of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Su
authors.affiliation: Department of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Kai-Lun
authors.initials: KL
authors.lastname: Shih
authors.affiliation: 1] Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan [2] Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan [3] Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Der-Cherng
authors.initials: DC
authors.lastname: Tarng
authors.affiliation: Department of Medical Imaging, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Chen-Te
authors.initials: CT
authors.lastname: Chou
authors.affiliation: Inflammation Research &Drug Development Center, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Ting-Yu
authors.initials: TY
authors.lastname: Chen
authors.affiliation: Internal Medicine Research Center, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Chew-Teng
authors.initials: CT
authors.lastname: Kor
authors.affiliation: 1] Inflammation Research &Drug Development Center, Changhua Christian Hospital, Changhua, Taiwan [2] Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan [3] Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Hung-Ming
authors.initials: HM
authors.lastname: Wu
mesh_terms: D015415:Biomarkers / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D010865:Pilot Projects
chemical_list: D015415:Biomarkers; C114753:CXCL10 protein, human; D054357:Chemokine CXCL10