title: Synergistic Cu-amine catalysis for the enantioselective synthesis of chiral cyclohexenones.
abstract: An unprecedented utilization of 1,3-acetonedicarboxylic acid as a 1,3-bis-pro-nucleophile and a reactive acetone surrogate in enantioselective catalysis has been reported. By synergistically activating the ketodiacid by copper catalysis and an α,β-unsaturated aldehyde by amine catalysis, an efficient domino di-decarboxylative Michael/aldol/dehydration sequence takes place leading to valuable chiral cyclohexenones in one single operation in 94 to 99% ee.
authors.affiliation: Aix Marseille Université, Centrale Marseille, CNRS, iSm2 UMR 7313, 13397, Marseille, France. adrien.quintard-inv@univ-amu.fr jean.rodriguez@univ-amu.fr.
authors.forename: A
authors.initials: A
authors.lastname: Quintard
authors.forename: J
authors.initials: J
authors.lastname: Rodriguez