title: The first case of feline sinonasal aspergillosis due to Aspergillus fischeri in Japan.
abstract: Feline upper respiratory tract infection due to Aspergillus spp. is considered an emerging disease, with the number of reported cases continuing to rise. In this study, we report the first case of feline sinonasal aspergillosis caused by Aspergillus fischeri in Japan. The patient presented after 2 months of progressive facial deformity around the nose and nasal discharge. The isolate from this case was susceptible to itraconazole (ITZ), voriconazole and micafungin, but was resistant to amphotericine B. However, the infected cat died approximately 1 month after referral, despite treatment for 12 days ITZ administered orally at 10 mg/kg.
authors.affiliation: Veterinary Pathobiology, Nihon University College of Bioresource Sciences, 1866 Kameino, Fujisawa, Kanagawa 252-0880, Japan.
authors.forename: Rui
authors.initials: R
authors.lastname: Kano
authors.forename: Tomoko
authors.initials: T
authors.lastname: Takahashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamaya
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kamata
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D001230:Aspergillus / Q000235:genetics; D001483:Base Sequence; D002371:Cat Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D002415:Cats / Q000382:microbiology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D009296:Nasal Cavity / Q000382:microbiology / Q000473:pathology; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary
chemical_list: D000935:Antifungal Agents