title: CuSO4/KI As Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazolo-Nucleosides.
abstract: A simple and inexpensive procedure has been developed for the selective formation of 1,4-disubstituted-1,2,3-triazolo-nucleosides starting from organic azides and terminal alkynes, mediated by in situ generated copper(I) catalyst from readily available CuSO4 and KI.
authors.affiliation: a Laboratory of Biomolecular and Medicinal Chemistry, Faculty of Science Semlalia , Cadi Ayyad University , Marrakech , Morocco.
authors.forename: Hanane
authors.initials: H
authors.lastname: Elayadi
authors.forename: Hassan Bihi
authors.initials: HB
authors.lastname: Lazrek
mesh_terms: D002384:Catalysis; D019327:Copper Sulfate / Q000737:chemistry*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D011193:Potassium Iodide / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D009705:Nucleosides; D014230:Triazoles; D011193:Potassium Iodide; D019327:Copper Sulfate
keywords: 1,2,3-triazolyl nucleoside; Copper catalysts; CuSO4/KI; click reaction; one-pot [3+2] cycloaddition