title: Rosiglitazone improves learning and memory ability in rats with type 2 diabetes through the insulin signaling pathway.
abstract: Diabetes mellitus (DM) is associated with moderate cognitive deficits and neurophysiologic and structural changes in the brain, a condition that is referred to as diabetic encephalopathy. This study was performed to investigate the effect of rosiglitazone (RSG) on learning and memory in rats with DM and elucidate possible mechanisms underlying this condition. Thirty-two male Sprague-Dawley rats were randomly divided into 4 groups: control (C, n = 8), DM (n = 8), RSG-administered control (C + RSG, n = 8) and RSG-administered DM groups (DM + RSG, n = 8). At 8 weeks after drug administration, Morris water maze was used to perform a training and probe trial to detect spatial learning and memory abilities. Western blot and immunohistochemistry were also used to detect changes in proteins involved in the insulin signal transduction pathway, such as the insulin receptor, insulin receptor substrate-1, protein kinase B, phosphorylated cAMP response element-binding protein and B-cell lymphoma 2, in the hippocampus of the rats. This study found that RSG could normalize the impaired insulin signal transduction in type 2 DM. The authors showed that RSG modulated the central insulin signaling axis.
authors.affiliation: Central Laboratory (LM, ZS, RW, ZZ, WD, JZ, XZ, SS, ZJ, JZ), Xuan Wu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China; and Department of Geriatrics (LM), Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Ma
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Shao
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Zhao
authors.forename: Wen
authors.initials: W
authors.lastname: Dong
authors.forename: Jingshuang
authors.initials: J
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Shuli
authors.initials: S
authors.lastname: Sheng
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Ji
authors.forename: Jingyan
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007328:Insulin / Q000378:metabolism*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077154:Rosiglitazone; D015398:Signal Transduction / Q000187:drug effects*; D045162:Thiazolidinediones / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D007328:Insulin; D045162:Thiazolidinediones; D000077154:Rosiglitazone