title: Electrochemical determination of hydrochlorothiazide and folic acid in real samples using a modified graphene oxide sheet paste electrode.
abstract: A new ferrocene-derivative compound, 2-chlorobenzoyl ferrocene, was synthesized and used to construct a modified graphene oxide sheet paste electrode. The electrooxidation of hydrochlorothiazide at the surface of the modified electrode was studied. Under optimized conditions, the square wave voltammetric (SWV) peak current of hydrochlorothiazide increased linearly with hydrochlorothiazide concentration in the range of 5.0 × 10(-8) to 2.0 × 10(-4) M and a detection limit of 20.0 nM was obtained for hydrochlorothiazide. The diffusion coefficient and kinetic parameters (such as electron transfer coefficient and the heterogeneous rate constant) for hydrochlorothiazide oxidation were also determined. The prepared modified electrode exhibits a very good resolution between the voltammetric peaks of hydrochlorothiazide and folic acid which makes it suitable for the detection of hydrochlorothiazide in the presence of folic acid in real samples.
authors.affiliation: Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran. Electronic address: h.beitollahi@yahoo.com.
authors.forename: Hadi
authors.initials: H
authors.lastname: Beitollahi
authors.affiliation: Department of Chemistry, Graduate University of Advanced Technology, Kerman, Iran.
authors.forename: Mozhdeh
authors.initials: M
authors.lastname: Hamzavi
authors.affiliation: Biotechnology Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Torkzadeh-Mahani
mesh_terms: D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D005492:Folic Acid / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D006852:Hydrochlorothiazide / Q000737:chemistry*
chemical_list: D006852:Hydrochlorothiazide; D006108:Graphite; D005492:Folic Acid
keywords: Carbon paste electrode; Folic acid; Graphene oxide sheets; Hydrochlorothiazide