title: Retinoblastoma genetics in India: From research to implementation.
abstract: Retinoblastoma is the prototypic genetic cancer. India carries the biggest burden of retinoblastoma globally, with an estimated 1500 new cases annually. Recent advances in retinoblastoma genetics are reviewed, focusing specifically on information with clinical significance to patients. The Indian literature on retinoblastoma clinical genetics is also highlighted, with a comment on challenges and future directions. The review concludes with recommendations to help clinicians implement and translate retinoblastoma genetics to their practice.
authors.affiliation: Department of Ophthalmology and Vision Sciences, University of Toronto, Canada; Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Canada; Department of Human Pathology, University of Nairobi, Nairobi, Kenya, .
authors.forename: Helen
authors.initials: H
authors.lastname: Dimaras
mesh_terms: D035843:Biomedical Research; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India / Q000453:epidemiology; D009017:Morbidity / Q000639:trends; D019572:Retinal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D012175:Retinoblastoma / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D056286:Retinoblastoma Binding Proteins / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics
chemical_list: C000606393:RB1 protein, human; D056286:Retinoblastoma Binding Proteins; D044767:Ubiquitin-Protein Ligases