title: Nuclear survivin expression in small cell lung cancer.
abstract: OBJECTIVE
  Little evidence exists regarding a relationship between survivin expression and prognosis in small cell lung cancer (SCLC). We investigated the relationship between survivin expression, clinical characteristics and prognosis in SCLC patients.
  
  
  METHODS
  We retrospectively reviewed medical records of study patients and analyzed their tumor sections using nuclear survivin labeling index (LI).
  
  
  RESULTS
  A significant correlation between nuclear survivin LI and clinical stage was found (p=0.012). In multivariate analysis, a significant association was found between survival and clinical stage (hazard ratio (HR)=2.09; 95 % confidence interval (CI)=1.08-4.31; p=0.027) but not between survival and nuclear survivin LI (HR=0.96; 95 % CI=0.91-1.02; p=0.2).
  
  
  CONCLUSIONS
  We did not find any positive relationship between nuclear survivin expression and survival in SCLC patients. Conversely, we found a positive relationship between clinical stage and nuclear survivin LI, which is considered to be useful in deciding treatment strategies.
authors.affiliation: Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan yanoy@toneyama.go.jp.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Yano
authors.affiliation: Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate school of Medicine, Suita, Osaka, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Otsuka
authors.affiliation: Department of Laboratory Medicine, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirano
authors.affiliation: Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Uenami
authors.affiliation: Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Satomi
authors.affiliation: Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Muneyoshi
authors.initials: M
authors.lastname: Kuroyama
authors.affiliation: Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Niinaka
authors.affiliation: Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yoneda
authors.affiliation: Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Kimura
authors.affiliation: Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Mori
authors.affiliation: Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Department of Thoracic Oncology, National Hospital Organization Toneyama National Hospital, Toyonaka, Osaka, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Yokota
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics*; D003593:Cytoplasm / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D055752:Small Cell Lung Carcinoma / Q000235:genetics* / Q000473:pathology; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin
keywords: Small cell lung cancer; immunohistochemistry; labeling index; nucleus; survivin