title: Biotin-guided anticancer drug delivery with acidity-triggered drug release.
abstract: A novel biotin-guided anticancer drug delivery system, prodrug , consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.
authors.affiliation: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors.forename: Soyeon
authors.initials: S
authors.lastname: Park
authors.forename: Eunjin
authors.initials: E
authors.lastname: Kim
authors.forename: Won Young
authors.initials: WY
authors.lastname: Kim
authors.forename: Chulhun
authors.initials: C
authors.lastname: Kang
authors.forename: Jong Seung
authors.initials: JS
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001710:Biotin / Q000378:metabolism*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D065546:Drug Liberation; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018613:Microscopy, Confocal; D011355:Prodrugs / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D011355:Prodrugs; D001710:Biotin