title: An Australian cohort of 210 patients with multiple invasive squamous cell carcinomas: risk factors and associated increased risk of melanoma and internal malignancies.
abstract: BACKGROUND
  Patients with a history of non-melanoma skin cancer (NMSC) have a 50% risk of developing subsequent NMSC.(13) Currently there are limited data on the association between multiple squamous cell carcinomas (SCC) and the risk of other cancers, including melanomas.
  
  
  OBJECTIVE
  To assess the risk factors in a cohort of 210 Australians with a history of multiple invasive SCC, focusing on the association between multiple SCC and other cancers.
  
  
  METHODS
  Data were collected from patients of a private practice in south-east Queensland.
  
  
  RESULTS
  A fair complexion and childhood sun exposure were found to be common in this cohort. Approximately half the patients who had their first SCC at or before the age of 30 years subsequently developed a melanoma. There was also an increased risk of internal cancer, prostate cancer being the commonest, followed by bowel and breast cancer.
  
  
  CONCLUSIONS
  Patients with a history of multiple invasive SCC should be aware of their increased risk of future NMSC and of melanomas. The results of thisstudy suggest such patients and their care providers should also consider an appropriate screening for internal malignancies.
authors.affiliation: Dermatology Research Centre, The University of Queensland, School of Medicine, Translational Research Institute, Brisbane, Queensland, Australia.
authors.forename: Parastoo
authors.initials: P
authors.lastname: Banan
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
authors.forename: Salman K
authors.initials: SK
authors.lastname: Marvi
authors.affiliation: Department of Dermatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
authors.forename: Erin
authors.initials: E
authors.lastname: McMeniman
authors.affiliation: Department of Dermatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.|School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.|South East Dermatology, Brisbane, Queensland, Australia.
authors.forename: Brian
authors.initials: B
authors.lastname: De'Ambrosis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D001943:Breast Neoplasms / Q000453:epidemiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology*; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000473:pathology*; D013472:Sunlight
keywords: Australia; cohort; internal cancer; melanoma; non melanoma skin cancer; risk; skin cancer; squamous cell carcinoma