title: Clinical, pathological and unusual MRI features of five synovial sarcomas in head and neck.
abstract: OBJECTIVE
  Synovial sarcoma (SS) of the head and neck is an unusual malignancy. This article documents five SSs in this region.
  
  
  METHODS
  All the patients underwent MR examinations. Four lesions received surgical ablation; one was treated with radiotherapy before surgery. The clinical, pathological and MRI features were reviewed.
  
  
  RESULTS
  Four of all five cases were monophasic fibrous-type SS, and the other one was biphasic type that was the fourth documented SS located in the nasopharynx. The symptoms were varied. All the masses were well defined, mainly homogeneous and solid; three of them arose adjacent to the minor joint. The mass parenchyma showed isointense signal on T1 weighted imaging similar to that of the skeletal muscle and hyperintense signal on T2 weighted imaging with remarkable enhancement. Two cases were found with fibrous septum, one with haemorrhage and one with cystic degeneration. Epithelial membrane antigens (EMAs) were all positive. The positive rate of cytokeratin (CK), part pan-CK antibody (AE1/3) and vimentin (Vim) were 50%, 75%, 75%, respectively.
  
  
  CONCLUSIONS
  Well-defined head and neck masses frequently arise adjacent to the minor joint, which are mainly homogeneous and solid, with isointense signal on T1 weighted MRI and hyperintense signal on T2 weighted MRI, and remarkable enhancement should evoke the diagnosis of SS. The positive staining of Vim\AE1/3\EMA and CK facilitates the final diagnosis.
  
  
  CONCLUSIONS
  The article documents the fourth SS involving the nasopharynx; other locations were also uncommon; three of them arose adjacent to the minor joint. The clinical, pathology and uncommon MR features of SS in the head and neck are also documented.
authors.affiliation: 1 Department of Radiology, Children's Hospital of Fudan University, Shanghai, China.
authors.forename: P A
authors.initials: PA
authors.lastname: Hu
authors.forename: Z R
authors.initials: ZR
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA