title: Long-Term Normal Renal Function after Drastic Weight Reduction in Patients with Obesity-Related Glomerulopathy.
abstract: OBJECTIVE
  No long-term studies of renal function evolution in morbidly obese (MO) patients after weight loss are available. The aim of our work was to ascertain the long-term influence of drastic weight reduction on renal function in MO patients with obesity-related glomerular lesions.
  
  
  METHODS
  92 MO patients with normal renal function and biopsy evidence of mild obesity-related glomerulopathy underwent bariatric surgery (BS) and subsequent drastic weight loss. A long-term prospective follow-up (mean duration: 76 ± 42 months) was carried out. Basal renal biopsies and basal and long-term metabolic and renal function studies were performed in all cases. Linear mixed models were applied.
  
  
  RESULTS
  Blood pressure dropped early after BS and remained stable thereafter. Creatinine clearance and BMI fell in the first 2 years, rose slightly after 5 years and then remained stable. Serum creatinine and albuminuria decreased throughout the follow-up period. Renal function and albuminuria evolution showed non-significant differences in relation to the number of glomerular lesions.
  
  
  CONCLUSIONS
  Drastic weight loss in BS-treated MO patients with pre-surgical normal renal function and mild obesity-related glomerular lesions is associated with short- and long-term maintenance of normal renal function and improvement in both arterial hypertension and albuminuria.
authors.affiliation: Department of Nephrology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
authors.forename: Assumpta
authors.initials: A
authors.lastname: Serra
authors.forename: Anna
authors.initials: A
authors.lastname: Esteve
authors.forename: Maruja
authors.initials: M
authors.lastname: Navarro-Díaz
authors.forename: Dolores
authors.initials: D
authors.lastname: López
authors.forename: Ioana
authors.initials: I
authors.lastname: Bancu
authors.forename: Ramón
authors.initials: R
authors.lastname: Romero
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000209:etiology; D050110:Bariatric Surgery; D001794:Blood Pressure / Q000502:physiology; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology; D007668:Kidney / Q000502:physiology / Q000503:physiopathology; D007674:Kidney Diseases / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000473:pathology / Q000601:surgery; D011446:Prospective Studies; D015431:Weight Loss / Q000502:physiology*
chemical_list: D003404:Creatinine