title: Early treatment in preschool children: an evidence-based approach.
abstract: OBJECTIVE
  Wheezing is a common symptom in early childhood but only some of these children will experience continued wheezing symptoms in later childhood making the diagnosis and treatment of these children challenging. This review covers recent findings regarding the epidemiology, diagnosis, evaluation, and treatment of preschool-aged children with asthma.
  
  
  RESULTS
  Key characteristics that distinguish the childhood asthma-predictive phenotype include male sex, history of wheezing with lower respiratory tract infections, history of parental asthma, history of atopic dermatitis, eosinophilia, early sensitization to food or aeroallergens, or lower lung function in early life. The preschool-aged asthma population tends to be characterized as exacerbation prone with relatively limited impairment. The diagnosis of asthma in preschool-aged children is often based on symptom patterns, presence of risk factors, and therapeutic responses. Asthma management includes intermittent and daily inhaled corticosteroids, daily leukotriene-receptor antagonists, and, in rare cases, combination therapies.
  
  
  CONCLUSIONS
  The diagnosis of asthma in preschool-aged children is based on symptom patterns and the presence of risk factors, and the goals of asthma management are achieved through a partnership between the family and the healthcare team using regular assessment of symptom control and response to daily controller therapy.
authors.affiliation: aDivision of Pulmonology Medicine bDivision of Allergy, Department of Pediatrics, Cincinnati Children's Hospital and Medical Center, Cincinnati, Ohio, USA.
authors.forename: Sheharyar
authors.initials: S
authors.lastname: Durrani
authors.forename: Theresa W
authors.initials: TW
authors.lastname: Guilbert
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D001249:Asthma / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D055317:Evidence-Based Practice / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D008297:Male; D012737:Sex Factors
chemical_list: D000305:Adrenal Cortex Hormones; D020024:Leukotriene Antagonists