title: No difference in the incidence of malaria in human-landing mosquito catch collectors and non-collectors in a Senegalese village with endemic malaria.
abstract: BACKGROUND
  The human landing catches is the gold standard method used to study the vectors of malaria and to estimate their aggressiveness. However, this method has raised safety concerns due to a possible increased risk of malaria or other mosquito-borne diseases among the mosquito collectors. The aim of this study was to evaluate the incidence of malaria attacks among mosquito collectors and to compare these results with those of non-collectors in a Senegalese village.
  
  
  METHODS
  From July 1990 to December 2011, a longitudinal malaria study involving mosquito collectors and non-collectors was performed in Dielmo village, Senegal. During the study period, 4 drugs were successively used to treat clinical malaria, and long-lasting insecticide-treated nets were offered to all villagers in July 2008. No malaria chemoprophylaxis was given to mosquito collectors. Incidence of uncomplicated clinical malaria and asymptomatic malaria infection were analyzed among these two groups while controlling for confounding factors associated with malaria risk in random effects negative binomial and logistic regression models, respectively.
  
  
  RESULTS
  A total of 3,812 person-trimester observations of 199 adults at least 15 years of age were analyzed. Clinical malaria attacks accounted for 6.3% both in collectors and non-collectors, and asymptomatic malaria infections accounted for 21% and 20% in collectors and non-collectors, respectively. A non-significant lower risk of malaria was observed in the collector group in comparison with the non-collector group after adjusting for other risk factors of malaria and endemicity level (Clinical malaria: adjusted incidence rate ratio = 0.89; 95% confidence interval = 0.65-1.22; p= 0.47).
  
  
  CONCLUSIONS
  Being a mosquito collector in Dielmo was not significantly associated with an increased risk of malaria both under holoendemic, mesoendemic and hypoendemic conditions of malaria epidemiology. This result supports the view that HLC, the most accurate method for evaluating malaria transmission, may be used without health concerns in Dielmo.
authors.affiliation: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes, IRD (Institut de Recherche pour le Développement), UMR (Unité Mixte de Recherche) 198, UM63, CNRS (Centre national de la recherche scientifique) 7278, INSERM (Institut national de la santé et de la recherche médicale) 1095, Aix-Marseille Université, Campus UCAD (Université Cheikh Anta Diop de Dakar)-IRD, BP 1386, CP 18524, Dakar, Sénégal; Université Cheikh Anta Diop de Dakar, Faculté des Sciences et Techniques, Laboratoire de Parasitologie, Dakar, Sénégal.
authors.forename: Amélé N
authors.initials: AN
authors.lastname: Wotodjo
authors.affiliation: Institut de Recherche pour le Développement, Laboratoire de Paludologie, Dakar, Sénégal.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Trape
authors.affiliation: Institut Pasteur de Dakar, Unité d'Épidémiologie, Dakar, Sénégal.
authors.forename: Vincent
authors.initials: V
authors.lastname: Richard
authors.affiliation: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes, IRD (Institut de Recherche pour le Développement), UMR (Unité Mixte de Recherche) 198, UM63, CNRS (Centre national de la recherche scientifique) 7278, INSERM (Institut national de la santé et de la recherche médicale) 1095, Aix-Marseille Université, Campus UCAD (Université Cheikh Anta Diop de Dakar)-IRD, BP 1386, CP 18524, Dakar, Sénégal.
authors.forename: Souleymane
authors.initials: S
authors.lastname: Doucouré
authors.affiliation: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes, IRD (Institut de Recherche pour le Développement), UMR (Unité Mixte de Recherche) 198, UM63, CNRS (Centre national de la recherche scientifique) 7278, INSERM (Institut national de la santé et de la recherche médicale) 1095, Aix-Marseille Université, Campus UCAD (Université Cheikh Anta Diop de Dakar)-IRD, BP 1386, CP 18524, Dakar, Sénégal.
authors.forename: Nafissatou
authors.initials: N
authors.lastname: Diagne
authors.affiliation: Institut Pasteur de Dakar, Unité d'Épidémiologie, Dakar, Sénégal.
authors.forename: Adama
authors.initials: A
authors.lastname: Tall
authors.affiliation: Institut Pasteur International Network, G4 Leader Group, Institut pasteur of Bangui, Bangui, Central African Republic.
authors.forename: Ousmane
authors.initials: O
authors.lastname: Ndiath
authors.affiliation: Université Cheikh Anta Diop de Dakar, Faculté des Sciences et Techniques, Laboratoire de Parasitologie, Dakar, Sénégal.
authors.forename: Ngor
authors.initials: N
authors.lastname: Faye
authors.affiliation: Aix-Marseille Université, UMR (Unité Mixte de Recherche) 912, SESSTIM (Sciences Économiques & Sociales de la Santé & Traitement de l'Information Médicale), (INSERM-IRD-AMU), Marseille, 13005, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Gaudart
authors.affiliation: Institut Pasteur de Madagascar, Antananarivo, Madagascar; Institut de Recherche Biomédicale des Armées, Brétigny sur Orge, France; Aix Marseille Université, Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes, UM 63, CNRS (Centre national de la recherche scientifique) 7278, IRD 198, INSERM 1095, Marseille, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Rogier
authors.affiliation: Unité de Recherche sur les Maladies Infectieuses et Tropicales Émergentes, IRD (Institut de Recherche pour le Développement), UMR (Unité Mixte de Recherche) 198, UM63, CNRS (Centre national de la recherche scientifique) 7278, INSERM (Institut national de la santé et de la recherche médicale) 1095, Aix-Marseille Université, Campus UCAD (Université Cheikh Anta Diop de Dakar)-IRD, BP 1386, CP 18524, Dakar, Sénégal.
authors.forename: Cheikh
authors.initials: C
authors.lastname: Sokhna
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D009033:Culicidae / Q000469:parasitology*; D019353:Endemic Diseases; D005260:Female; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology*; D007306:Insecticides / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy / Q000453:epidemiology / Q000469:parasitology* / Q000635:transmission; D008297:Male; D008875:Middle Aged; D012675:Senegal / Q000453:epidemiology
chemical_list: D007306:Insecticides