title: The Nature's Clever Trick for Making Cyclic Dinucleotide.
abstract: Ever since their initial discovery few years ago, cyclic dinucleotides (cDNs), their biosynthesis, and their biological function have been in focus of intense research efforts. In this issue, Kato et al. (2015) present strong evidence that the key enzyme in cDN biosynthesis, DncV, is poised on a tipping point such that, given a nudge, the enzyme, can link the nucleotides into a distinct cyclic loop, leading to a specific innate immune response.
authors.affiliation: Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Fang
authors.affiliation: Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA. Electronic address: guomin@scripps.edu.
authors.forename: Min
authors.initials: M
authors.lastname: Guo
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology*; D014734:Vibrio cholerae / Q000201:enzymology*
chemical_list: D001426:Bacterial Proteins; D000242:Cyclic AMP; D006152:Cyclic GMP