title: Three decomposition products of valepotriates from Valeriana jatamansi and their cytotoxic activity.
abstract: Three new decomposition products of valepotriates, valtrals A-C (1-3), and two known products, baldrinal and homobaldrinal, are formed during the isolation procedure of the ethanol extract of the whole plants of Valeriana jatamansi. Their structures were determined by spectroscopic methods including IR, MS, 1D, and 2D NMR experiments. Compounds 1-3 showed selective cytotoxicity against metastatic prostate cancer (PC-3M) and colon cancer (HCT-8) cell lines.
authors.affiliation: a Department of Natural Product Chemistry , School of Pharmacy, Second Military Medical University , Shanghai 200433 , China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.forename: Ji
authors.initials: J
authors.lastname: Ye
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Shan
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Li
authors.forename: Run-Hui
authors.initials: RH
authors.lastname: Liu
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Xi-Ke
authors.initials: XK
authors.lastname: Xu
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D032404:Nardostachys; D019906:Nuclear Magnetic Resonance, Biomolecular; D011471:Prostatic Neoplasms / Q000188:drug therapy; D014632:Valerian / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D039823:Iridoids; C000601884:valtral A; C000601885:valtral B; C000601886:valtral C; C047843:baldrinal; C047844:homobaldrinal
keywords: Valeriana jatamansi; cytotoxicity; valepotriates; valtrals A–C