title: Steroid-responsive nephrotic syndrome in a patient with proliferative glomerulonephritis with monoclonal IgG deposits with pure mesangial proliferative features.
abstract: A 78-year-old woman developed acute-onset nephrotic syndrome. A renal biopsy showed mild mesangial proliferative glomerulonephritis. Immunofluorescence studies revealed granular IgG3- λ deposits within the mesangial area and along the glomerular capillary walls. Electron microscopy showed mesangial and subendothelial granular electron-dense deposits. The pattern of deposition was predominantly mesangial. Serum or urine monoclonal proteins were not detected. Middle-dose steroid therapy induced a rapid remission of nephrotic syndrome. We consider that this is the first case of steroid-responsive nephrotic syndrome due to an extremely rare glomerular disease, proliferative glomerulonephritis with monoclonal IgG deposits associated with pure mesangial proliferative features.
authors.affiliation: Department of Hematology, Nephrology, and Rheumatology , Akita University Graduate School of Medicine , Akita , Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Komatsuda
authors.affiliation: Department of Hematology, Nephrology, and Rheumatology , Akita University Graduate School of Medicine , Akita , Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Wakui
authors.affiliation: Department of Nephrology and Dialysis , Akita Kumiai General Hospital , Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohtani
authors.affiliation: Department of Internal Medicine , Senboku Kumiai General Hospital , Daisen , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nimura
authors.affiliation: Department of Hematology, Nephrology, and Rheumatology , Akita University Graduate School of Medicine , Akita , Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Sawada
keywords: proliferative glomerulonephritis with monoclonal IgG deposits; steroid-responsive nephrotic syndrome