title: Humoral immunity status if infertile men antisperm antibodies and various pathologies of reproductive organs.
abstract: The aim of the research was to study humoral immunity status of infertile men with high concentration of antisperm antibodies in blood plasma, sexually transmitted diseases (STD) and various pathologies of reproductive system. Analysis of 496 outpatient cards has been conducted. It was found, that patients with high levels of ASA >150 mg/l, or average 100-150 mg/l, had statistically significant (p=0,001) high content of Ig A and Ig G relative to the control group. Men with serum ASA concentration >100 mg/l, had statistically insignificant increased levels of all 3 types of immunoglobulins relative to the control group. Patients infected with Chlamydia trachomatis proved to have decreased IgA and IgG, 0,95±0,12 and 6,64±0,5 respectively (p<0,001). As for the patients infected with Ureaplasma urealyticum, decreased levels in Ig A and Ig M have been reported as 0,75±0,29 and 1,08±0,08 respectively (p<0,05). In the course of prostate gland inflammation statistically significant deficiency of Ig A and IgG was evident relative to the control group, 0,75±0,10 g/l and 5,94±0,54 g/l respectively (p<0,001). As for the males with varicocele, Ig A and Ig M decrease is noticeable relative to the control group, 1,06±0,21 g/l and 0,61±0,19 g/l respectively (p<0,05).
authors.affiliation: 1David Tvildiani Medical University, Tbilisi; 2Ivane Javakhishvili Tbilisi State University, Medical Faculty; 3National Centre of Dermatology and Venerology, Tbilisi, Georgia.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Tchiokadze
authors.affiliation: 1David Tvildiani Medical University, Tbilisi; 2Ivane Javakhishvili Tbilisi State University, Medical Faculty; 3National Centre of Dermatology and Venerology, Tbilisi, Georgia.
authors.forename: G
authors.initials: G
authors.lastname: Galdava
mesh_terms: D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000276:immunology* / Q000302:isolation & purification; D002690:Chlamydia Infections / Q000150:complications / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D056724:Immunity, Humoral; D007248:Infertility, Male / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012098:Reproduction / Q000276:immunology / Q000502:physiology; D012749:Sexually Transmitted Diseases / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D013094:Spermatozoa / Q000276:immunology / Q000473:pathology; D016990:Ureaplasma urealyticum / Q000276:immunology / Q000472:pathogenicity
chemical_list: D000906:Antibodies