title: [Short and long term efficacy of immunosuppressive therapy and survival in adult severe aplastic anemia].
abstract: OBJECTIVE
  To evaluate the short and long term therapeutic efficacy of the immunosuppressive therapy(IST) for adult severe aplastic anemia(SAA), and to analysis the relationship between the clinical factors(age, typing, lymphocyte percentage, reticulocyte percentage, neutrophil count) and the response to IST.
  
  
  METHODS
  The response rate of 39 patients received the IST between September 2009 and September 2013 in our hospital was assayed, the effective time in which all patients had hematologic response, and the survival rate at the first year were analyzed. The survival rates, the average amounts of the RBC and Plt transfusion per month in the first year were compared by using χ2 test between the IST group and the non-IST group; the multinomial logistic regression was used to analyze the relationship between the clinical factors and the response to IST.
  
  
  RESULTS
  The response rates of the 39 SAA patients at the first month, the third month, the sixth month and the first year were 29.73%, 70.27%, 75.68%, 86.49%, respectively. The median effective time of hematologic response in all patients had was 61.5 d(10 d-344 d). The survival rate of the IST group was 92.31%, which was much higher than that of the non-IST group (P<0.05). The average amounts of the RBC and Plt transfusion per month at the first year in the IST group were 1.04(0.13-2.78)×400 ml and 1.38(0.17-5.10)×200 ml, respectively, which were much lower than those in the non-IST group (P<0.01). Among the five clinical factors, the age, lymphocyte percentage and neutrophil count related to the response of IST (P<0.05).
  
  
  CONCLUSIONS
  The response rate of the 39 SAA patients received IST is 86.49% at the first year, and their long term survival is better than that of non-IST group. The age, lymphocyte percentage and neutrophil count relate to the response of IST.
authors.affiliation: Department of Hematology, The Second Affilitated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. E-mail: maxr0910@163.com.
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Ma
authors.affiliation: Department of Hematology, The Second Affilitated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.affiliation: Department of Hematology, The Second Affilitated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hematology, The Second Affilitated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Wang-Gang
authors.initials: WG
authors.lastname: Zhang
authors.affiliation: Department of Hematology, The Second Affilitated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Xing-Mei
authors.initials: XM
authors.lastname: Cao
authors.affiliation: Department of Hematology, The Second Affilitated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Yin-Xia
authors.initials: YX
authors.lastname: Chen
authors.affiliation: Department of Hematology, The Second Affilitated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Ai-Li
authors.initials: AL
authors.lastname: He
authors.affiliation: Department of Hematology, The Second Affilitated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Hematology, The Second Affilitated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Wang
authors.affiliation: Department of Hematology, The Second Affilitated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic; D001803:Blood Transfusion; D016572:Cyclosporine; D006801:Humans; D007166:Immunosuppressive Agents; D007958:Leukocyte Count; D016015:Logistic Models; D009504:Neutrophils; D012156:Reticulocytes; D015996:Survival Rate
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine