title: Oncolytic virus expressing RANTES and IL-15 enhances function of CAR-modified T cells in solid tumors.
abstract: We improved the migration and survival of chimeric antigen receptor (CAR)-modified T cells in solid tumors by combining CAR-T cells with an armed oncolytic virus. Local delivery of the chemokine RANTES and the cytokine IL-15 by the oncolytic virus enhanced the trafficking and persistence of the CAR-T cells, resulting in improved antitumor effects.
authors.affiliation: Center for Cell and Gene Therapy; Baylor College of Medicine ; Houston, TX USA.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nishio
authors.affiliation: Center for Cell and Gene Therapy; Baylor College of Medicine ; Houston, TX USA ; Department of Immunology; Baylor College of Medicine ; Houston, TX USA ; Department of Medicine; Baylor College of Medicine ; Houston, TX USA.
authors.forename: Gianpietro
authors.initials: G
authors.lastname: Dotti
keywords: GD2 antigen; IL-15; RANTES; chimeric antigen receptor; oncolytic virus