title: Glioblastoma and intracranial aneurysms: Case report and review of literature.
abstract: BACKGROUND
  There is a paucity of data on the association of glioblastoma multiforme (GBM) with intracranial aneurysms. It is an important clinical entity for physicians to be aware of and its presence illustrates several critical features of the pathophysiology of malignant glioma. In this article we present a case of a middle cerebral artery (MCA) pseudoaneurysm that occurred in a patient with recurrent GBM as well discuss the current literature relating to this unique combination of pathologies.
  
  
  METHODS
  The authors present a case of a MCA pseudoaneurysm that developed in a patient with recurrent GBM and discuss the current literature. The authors identified 19 reports describing 23 patients harboring both GBM and an intracranial aneurysm.
  
  
  CONCLUSIONS
  Several theories stand to explain the coincidental occurrence of intracranial aneurysms and GBM. The treating physician should be aware of this association when patients with intraaxial tumors present with unusual manifestation such as an intratumoral hemorrhage or angiogram negative subarachnoid hemorrhage. No guidelines exist to assist in the management of such patients; therefore, authors have attempted to address this issue using a classification and treatment algorithm.
authors.affiliation: Department of Neurological Surgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Rushna
authors.initials: R
authors.lastname: Ali
authors.affiliation: Department of Neurological Surgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Aqueel
authors.initials: A
authors.lastname: Pabaney
authors.affiliation: Department of Neurological Surgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Robin
authors.affiliation: Department of Radiology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Horia
authors.initials: H
authors.lastname: Marin
authors.affiliation: Department of Neurological Surgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Rosenblum
keywords: Glioblastoma multiforme; intracranial aneurysm; pseudoaneurysm; subarachnoid hemorrhage