title: Metal-free N-arylation of secondary amides at room temperature.
abstract: The arylation of secondary acyclic amides has been achieved with diaryliodonium salts under mild and metal-free conditions. The methodology has a wide scope, allows synthesis of tertiary amides with highly congested aryl moieties, and avoids the regioselectivity problems observed in reactions with (diacetoxyiodo)benzene.
authors.affiliation: †Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Tinnis
authors.affiliation: †Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: Elin
authors.initials: E
authors.lastname: Stridfeldt
authors.affiliation: †Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: Helena
authors.initials: H
authors.lastname: Lundberg
authors.affiliation: †Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: Hans
authors.initials: H
authors.lastname: Adolfsson
authors.affiliation: †Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.|‡Stellenbosch Institute for Advanced Study (STIAS), Wallenberg Research Centre at Stellenbosch University, Marais Street, Stellenbosch 7600, South Africa.
authors.forename: Berit
authors.initials: B
authors.lastname: Olofsson
mesh_terms: D000577:Amides / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry; D006839:Hydrocarbons, Acyclic / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*; D012492:Salts / Q000737:chemistry*; D013696:Temperature
chemical_list: D000577:Amides; D001555:Benzene Derivatives; D006839:Hydrocarbons, Acyclic; D008670:Metals; D009861:Onium Compounds; D012492:Salts; D007455:Iodine