title: The Role Of Semaphorin 3A In The Skeletal System.
abstract: Semaphorin 3A (Sema3A), characterized by a conserved N-terminal "Sema" domain, was originally described as an axon guidance molecule. Recent research indicates that it performs a critical function in the skeletal system. This review highlights recent advances in understanding of the role of Sema3A in the skeletal system as a regulator of bone metabolism and as a potential drug target for bone disease therapy. We summarize Sema3A functions in osteoblastogenesis and osteoclastogenesis, as well as in innervation, and we discuss its multifunctional role in various bone diseases such as osteoporosis and low back pain. Despite limited research in this field, our aim is to promote further understanding of the function of Sema3A in the skeletal system.
authors.affiliation: Department of Orthopaedics, Chinese PLA General Hospital, Beijing China.
authors.forename: Peifu
authors.initials: P
authors.lastname: Tang
authors.affiliation: Department of Orthopaedics, Chinese PLA General Hospital, Beijing China.
authors.forename: Pengbin
authors.initials: P
authors.lastname: Yin
authors.affiliation: Department of Orthopaedics, Chinese PLA General Hospital, Beijing China.
authors.forename: Houchen
authors.initials: H
authors.lastname: Lv
authors.affiliation: Department of Orthopaedics, Chinese PLA General Hospital, Beijing China.
authors.forename: Licheng
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, Chinese PLA General Hospital, Beijing China.
authors.forename: Lihai
authors.initials: L
authors.lastname: Zhang
mesh_terms: D001842:Bone and Bones / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D017116:Low Back Pain / Q000235:genetics* / Q000503:physiopathology; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D010012:Osteogenesis / Q000235:genetics; D010024:Osteoporosis / Q000235:genetics* / Q000503:physiopathology; D040121:Semaphorin-3A / Q000235:genetics* / Q000378:metabolism
chemical_list: D040121:Semaphorin-3A