title: Functional Neuronavigation-Guided Transparieto-Occipital Cortical Resection of Meningiomas in Trigone of Lateral Ventricle.
abstract: BACKGROUND
  This study investigated whether functional neuronavigation can be used to remove lesions in the lateral ventricle while preserving patients' neurologic functionality.
  
  
  METHODS
  A total of 60 patients with lateral ventricular meningiomas were divided into study and control groups (n = 30 each). Diffusion tensor and blood oxygenation level-dependent functional magnetic resonance imaging were used for fiber tracking and eloquent cortex localization, respectively, in the study group. The surgical approach was based on coregistered data sets from 3-D lesion and brain structure reconstructions. Patients in the control group underwent anatomic neuronavigation-guided surgery. The patients' demographics, degree of resection, visual field, language score, movement, preoperative and postoperative Karnofsky Performance Status (KPS) scores, and surgical complications were recorded.
  
  
  RESULTS
  Tumors were completely removed in both groups. Patients in the study group had a higher rate of visual field preservation than controls (P = 0.01). The two groups had similar motor and language functions after surgery, except that fewer cases of transient aphasia were observed in the former (P < 0.05). KPS scores for the study and control groups were 80 (70-80) and 70 (60-70), respectively (P < 0.01), at 2 weeks and 90 (80-100) and 85 (70-90), respectively (P = 0.022), at 3 months after surgery.
  
  
  CONCLUSIONS
  Functional neuronavigation preserved neurologic functionality and was especially beneficial for protecting optical functionality and for the rapid recovery of patients.
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China.
authors.forename: Guo-chen
authors.initials: GC
authors.lastname: Sun
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China.
authors.forename: Xiao-lei
authors.initials: XL
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China.
authors.forename: Xin-guang
authors.initials: XG
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, PLA General Hospital, Beijing, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Radiology, PLA General Hospital, Beijing, China.
authors.forename: Bao-ke
authors.initials: BK
authors.lastname: Hou
authors.affiliation: Department of Neurosurgery, PLA General Hospital, Beijing, China. Electronic address: sjwk8082@126.com.
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020547:Lateral Ventricles / Q000601:surgery*; D008297:Male; D008579:Meningioma / Q000601:surgery*; D008875:Middle Aged; D038361:Neuronavigation / Q000379:methods*; D019635:Neurosurgical Procedures / Q000379:methods*; D009778:Occipital Lobe / Q000601:surgery*; D010296:Parietal Lobe / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D025321:Surgery, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome; D014794:Visual Fields; D055815:Young Adult
keywords: Functional neuronavigation; Image-guided surgery; Meningioma; Optic radiation