title: Polymorphisms in the DUSP10 gene are associated with sex-specific colorectal cancer risk in a Han population.
abstract: OBJECTIVE
  Colorectal cancer (CRC) is common, especially in developed countries. CRC is a multifactorial disease influenced by both environmental and genetic factors. In this study, we investigated the role of genetic polymorphisms in the dual specificity protein phosphatase 10 (DUSP10) gene especially in sex-specific.
  
  
  METHODS
  We selected nine DUSP10 tag single nucleotide polymorphisms (tSNPs) previously reported to be associated with colorectal cancer risk of in a case-control study from Xi'an city of China.
  
  
  RESULTS
  In females, three SNPs were associated with decreased CRC risk: rs11118838, rs12724393, and rs908858. However, in males, only one SNP, rs908858, was associated with decreased CRC risk. Using a log-additive model, the rs11118838 "C" allele and the rs12724393 "G" allele were associated with decreased CRC risk in females, while the rs908858 "G" allele was associated with decreased CRC risk in both females and males. In addition, haplotype analysis also found "CG" and "CCT" were associated with the decreased CRC risk in females.
  
  
  CONCLUSIONS
  Our findings suggest that DUSP10 polymorphisms influence the risk of developing CRC in Han Chinese and emphasize that sex should be considered in the design and analysis of health studies and biomedical research.
authors.affiliation: Second Department of General Surgery, Shaanxi Province Hospital Xi'an 710061, China ; School of Life Sciences, Northwest University Xi'an 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China.
authors.forename: Xianglong
authors.initials: X
authors.lastname: Duan
authors.affiliation: School of Medicine, Xi'an Jiaotong University Xi'an 710061, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Gao
authors.affiliation: School of Life Sciences, Northwest University Xi'an 710069, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Feng
authors.affiliation: School of Life Sciences, Northwest University Xi'an 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China.
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.affiliation: Second Department of General Surgery, Shaanxi Province Hospital Xi'an 710061, China.
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Long
authors.affiliation: School of Life Sciences, Northwest University Xi'an 710069, China ; National Engineering Research Center for Miniaturized Detection Systems Xi'an 710069, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D054637:Dual-Specificity Phosphatases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D054639:Mitogen-Activated Protein Kinase Phosphatases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors
chemical_list: C120407:DUSP10 protein, human; D054639:Mitogen-Activated Protein Kinase Phosphatases; D054637:Dual-Specificity Phosphatases
keywords: Colorectal cancer; DUSP10; case-control study; tag single nucleotide polymorphism (tSNP)