title: Tumor immune remodeling by TGFβ inhibition improves the efficacy of radiation therapy.
abstract: The tumor immune environment has been linked to prognosis in patients with a range of malignancies. Recently, we demonstrated in pre-clinical models that modifying the tumor immune environment using a small-molecule inhibitor of TGFb significantly improved outcome to subsequent radiation therapy. These data suggest that this and other immunotherapies may be used to remodel the tumor before conventional cancer therapies to improve outcomes.
authors.affiliation: Department of Radiation Medicine; Oregon Health & Science University ; Portland, OR, USA.
authors.forename: Kristina H
authors.initials: KH
authors.lastname: Young
authors.affiliation: Earle A. Chiles Research Institute; Providence Portland Medical Center ; Portland, OR, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gough
authors.affiliation: Earle A. Chiles Research Institute; Providence Portland Medical Center ; Portland, OR, USA ; The Oregon Clinic ; Portland, OR, USA.
authors.forename: Marka
authors.initials: M
authors.lastname: Crittenden
keywords: TGFβ; colorectal; immunoscore; immunotherapy; pancreas; radiation