title: Self-assembling peptide-based delivery of therapeutics for myocardial infarction.
abstract: Cardiovascular disease, including myocardial infarction, is the number one cause of death. Current treatments are palliative and slow the progression toward heart failure, but to not regenerate healthy tissue. Self-assembling peptides are biomimietic, readily produced, non-immunogenic and non-cytotoxic. They do not assemble into hydrogels until triggered, allowing them to be injected into the myocardium and providing opportunities for minimally invasive therapies. The ability to tune the mechanical and bioactive properties of self-assembling peptides will continue to make them readily adaptable for mimicking natural microenvironments. To date, a variety of growth factors and signaling moieties have been incorporated into self-assembling peptide hydrogels, enhancing cell behavior and tissue function. Furthermore, the hydrogels serve as delivery vehicles for cells in vivo and platforms for improved cell culture. In addition to a brief review of self-assembling peptides, we will discuss a variety of their approaches for myocardial infarction therapy. Moreover, we will assess approaches taken in other tissue and discuss how these could benefit therapies for myocardial infarction.
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Kristin M
authors.initials: KM
authors.lastname: French
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Inthirai
authors.initials: I
authors.lastname: Somasuntharam
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, USA; Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA; Children's Heart Research and Outcomes Center, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA, USA. Electronic address: michael.davis@bme.emory.edu.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Davis
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000628:therapy; D032383:Myocytes, Cardiac / Q000166:cytology / Q000637:transplantation; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry*; D011487:Protein Conformation; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D004337:Drug Carriers; D020100:Hydrogels; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides
keywords: Biomaterials; Biomimetic; Cell culture; Cell therapy; Material properties; Protein delivery; Tissue engineering