title: Higher Waist Circumference, Fasting Hyperinsulinemia And Insulin Resistance Characterize Hypertensive Patients With Impaired Glucose Metabolism.
abstract: Hypertensive patients are at higher risk of pre-diabetes (impaired fasting glucose IFG and impaired glucose tolerance IGT) and type 2 DM. This study was done to examine whether some general, anthropometric, hormone, and metabolic parameters are different between subjects with normal and impaired glucose metabolism (IGM) in hypertensive subjects, thus possibly identifying some variable characterizing glucose metabolism derangement in these patients. A cohort of 134 hypertensive patients, 55 women and 79 men, aged 37-70 years, were examined. IGM patients were considered those showing IFG and/or IGT or type 2 DM after an oral glucose tolerance test (OGTT), and/or HbA1c > 48 mmol/l (6.5%) and/or glucose levels >155 mg/dL after 1 hour of the OGTT. Body mass index (BMI), waist circumference, and fasting insulin, TSH, FT3, FT4, glucose, and lipid (cholesterol, HDL-cholesterol and triglycerides) plasma concentrations were measured. Insulin resistance was also assessed by the homeostasis model assessment (HOMAIR).
  
  
  RESULTS
  Waist circumference (p < 0.05), fasting glucose (p < 0.05) and insulin levels (p < 0.05) and HOMAIR (p < 0.05) were significantly higher in patients with IGM than in control group. All other investigated parameters, as well as the number of antihypertensive drugs per single patient, were not different between the two groups.
  
  
  CONCLUSIONS
  The present study, performed in a selected population of hypertensive subjects, shows that derangement of glucose metabolism is associated to central fat accumulation, hyperinsulinemia and insulin resistance.
authors.affiliation: Department of Internal Medicine and Clinical Oncology, University of Bari, Bari, Italy. giovanni.depergola@uniba.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Pergola
authors.forename: Adele
authors.initials: A
authors.lastname: Nardecchia
authors.forename: Michela
authors.initials: M
authors.lastname: Cirillo
authors.forename: Barbara
authors.initials: B
authors.lastname: Boninfante
authors.forename: Marcello
authors.initials: M
authors.lastname: Sciaraffia
authors.forename: Vito Angelo
authors.initials: VA
authors.lastname: Giagulli
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Triggiani
authors.forename: Franco
authors.initials: F
authors.lastname: Silvestris
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use; D015992:Body Mass Index; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology / Q000209:etiology*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D005260:Female; D018149:Glucose Intolerance / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D006946:Hyperinsulinism / Q000139:chemically induced / Q000150:complications*; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D007333:Insulin Resistance; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000139:chemically induced / Q000150:complications*; D011236:Prediabetic State / Q000139:chemically induced / Q000150:complications / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D055105:Waist Circumference / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents