title: [A baby with digoxin toxicity].
abstract: Accidental poisoning or overdoses occur frequently in children. These are difficult to recognise because young children cannot communicate their symptoms; this means that specific symptoms can be missed, which can delay the diagnosis. A 5-month-old boy was accidently given a tenfold dose of digoxin for 5 days. He developed feeding difficulties, vomiting, weight loss, elevated urea and creatinine levels, hyponatraemia, hyperkalaemia and ECG abnormalities. The digoxin plasma concentration was 7.6 µg/l. The patient was given digoxin antibodies, following which the digoxin concentration was < 0.3 µg/l; 12 hours later the digoxin concentration was 3.1 µg/l as a result of redistribution; 2 days after the administration of digoxin antibodies the plasma concentration was within the therapeutic range.
authors.affiliation: Erasmus Medisch Centrum, Rotterdam.
authors.forename: Louise M
authors.initials: LM
authors.lastname: Andrews
authors.forename: Patrycja J
authors.initials: PJ
authors.lastname: Puiman
authors.forename: Heleen
authors.initials: H
authors.lastname: van der Sijs
authors.forename: Ingrid M
authors.initials: IM
authors.lastname: van Beynum
mesh_terms: D000906:Antibodies / Q000008:administration & dosage*; D002316:Cardiotonic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004077:Digoxin / Q000009:adverse effects* / Q000627:therapeutic use; D062787:Drug Overdose; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced; D007223:Infant; D008297:Male; D008508:Medication Errors
chemical_list: D000906:Antibodies; D002316:Cardiotonic Agents; D004077:Digoxin