title: Polymorphisms of inflammatory markers and risk of essential hypertension in Tatars from Russia.
abstract: Essential hypertension (EH) is a common disease with a clear genetic component. Inflammation and endothelial dysfunction play a prominent role in the development of persistent blood pressure elevation. The aim of the current study was to detect an association between EH and polymorphic markers in genes encoding for molecules involved in the control of intercellular interactions during the inflammation process. We analysed SNPs in SELE, SELP, SELL, ICAM1, VEGFA, IL1B, IL6, IL10 and IL12B genes in a group of 534 men of Tatar ethnicity (217 patients with EH and 317 controls). Using a Markov chain Monte-Carlo-based approach (APSampler), we found genotype and allelic combinations associated with EH. The most significant associations were observed for SELE rs2076059*C-SELP rs6131*A-VEGFA -2549*I-IL1B rs16944*C (p = 3.42 × 10(-5), FDR q = 0.035) and SELE rs2076059*C-SELP rs6131*A-IL12B rs3212227*C-IL1B rs16944*C (p = 323 × 10(-4), FDR q = 0.035).
authors.affiliation: Institute of Biochemistry and Genetics of Ufa Scientific Centre RAS , Pr. Oktyabrya, Ufa , Russian Federation .
authors.forename: Yanina R
authors.initials: YR
authors.lastname: Timasheva
authors.forename: Timur R
authors.initials: TR
authors.lastname: Nasibullin
authors.forename: Elvira B
authors.initials: EB
authors.lastname: Imaeva
authors.forename: Vera V
authors.initials: VV
authors.lastname: Erdman
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
authors.forename: Ilsiyar A
authors.initials: IA
authors.lastname: Tuktarova
authors.forename: Irina E
authors.initials: IE
authors.lastname: Nikolaeva
authors.forename: Olga E
authors.initials: OE
authors.lastname: Mustafina
mesh_terms: D000483:Alleles; D044466:Asian People / Q000208:ethnology; D001486:Bashkiria / Q000208:ethnology; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D000075222:Essential Hypertension; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D007249:Inflammation / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012426:Russia / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D016207:Cytokines; D004247:DNA
keywords: Adhesion molecules; Tatars; cytokines; essential hypertension; genetic polymorphism; selectins