title: 99mTc-Tilmanocept: A Novel Molecular Agent for Lymphatic Mapping and Sentinel Lymph Node Localization.
abstract: Preoperative lymphatic mapping in conjunction with intraoperative γ-probe detection is widely used for sentinel node localization in melanoma, breast cancer, and other malignancies. (99m)Tc-radiocolloids have been the standard radiotracers used for sentinel node mapping. (99m)Tc-tilmanocept is a receptor-binding molecular imaging agent approved by the U.S. Food and Drug Administration for lymphatic mapping and lymph node localization in breast cancer, melanoma, clinically node-negative squamous cell carcinoma of the oral cavity, and other solid tumors. It has several advantages over conventional radiocolloids, including rapid injection site clearance, high sentinel node extraction, and low distal node accumulation, which can lead to efficient resource use.
authors.affiliation: Division of Molecular Imaging and Therapeutics, Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama dsurasi@uabmc.edu.
authors.forename: Devaki Shilpa
authors.initials: DS
authors.lastname: Surasi
authors.affiliation: Division of Molecular Imaging and Therapeutics, Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Janis
authors.initials: J
authors.lastname: O'Malley
authors.affiliation: Division of Molecular Imaging and Therapeutics, Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Pradeep
authors.initials: P
authors.lastname: Bhambhvani
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D003911:Dextrans; D006801:Humans; D008351:Mannans; D009062:Mouth Neoplasms / Q000175:diagnosis; D011849:Radioactive Tracers; D021701:Sentinel Lymph Node Biopsy / Q000191:economics / Q000379:methods*; D016284:Technetium Tc 99m Pentetate / Q000031:analogs & derivatives*
chemical_list: D003911:Dextrans; D008351:Mannans; D011849:Radioactive Tracers; C431884:technetium-diethylenetriaminepentaacetic acid-mannosyl-dextran; D016284:Technetium Tc 99m Pentetate
keywords: 99mTc-tilmanocept; Lymphoseek; molecular imaging; sentinel lymph node mapping