title: Vertebral Bone Marrow Edema (VBME) in Conservatively Treated Acute Vertebral Compression Fractures (VCFs): Evolution and Clinical Correlations.
abstract: METHODS
  Prospective observational study.
  
  
  OBJECTIVE
  To assess (1) the evolution of vertebral bone marrow edema (VBME) in patients with A1 vertebral compression fractures (VCFs) conservatively treated and (2) the relationship between VBME and clinical symptoms, evaluated as Visual Analogue Scale (VAS) back pain and Oswestry Disability Index (ODI).
  
  
  BACKGROUND
  VBME is a marker of acute-subacute vertebral fractures. Little is known about the evolution of VBME in conservatively managed VCFs, as well as its clinical meaning.
  
  
  METHODS
  82 thoracic or lumbar VCFs (21 post-traumatic; 61 osteoporotic VCFs), type A1 according to the AOSpine thoracolumbar spine injury classification system, in 80 patients were treated with C35 hyperextension brace for 3 months, bed rest for the first 25 days. Patients with osteoporotic fractures also received antiresorptive therapy and vitamin D supplementation. At 0 (T0), 30 (T1), 60 (T2), and 90 (T3) days, patients underwent magnetic resonance imaging evaluation and clinical evaluation, using VAS for pain and ODI.The paired t test was used to compare changes within groups at each follow-up versus baseline. The unpaired t test after ANOVA (analysis of variance) was used to compare the 2 groups at each follow-up.The association between VBME area, VAS score, and ODI score was analyzed by the Pearson correlation test. The tests were 2-tailed with a confidence level of 5%.
  
  
  RESULTS
  A significant VBME mean area, VAS, and ODI scores reduction was recorded at 60 and 90-days follow-ups versus baseline. A positive correlation between VBME reduction and clinical symptoms improvement (VAS and ODI scores improvement) was found in both traumatic and osteoporotic VCFs.
  
  
  CONCLUSIONS
  In benign A1 VCFs conservatively managed, VBME slowly decreases in the first 3 months of magnetic resonance imaging follow-up. This VBME reduction is related to clinical symptoms improvement.
  
  
  METHODS
  4.
authors.affiliation: *Department of Basic Medical Sciences, Neuroscience and Sense Organs, School of Medicine, University of Bari "Aldo Moro", Bari, Italy †IRCCS Istituto Ortopedico Galeazzi, Milan, Italy; and ‡IGEA SpA - Clinical Biophysics, Via Parmenide 10/A, 41012, Carpi (Mo), Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Piazzolla
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Solarino
authors.forename: Claudio
authors.initials: C
authors.lastname: Lamartina
authors.forename: Silvana
authors.initials: S
authors.lastname: De Giorgi
authors.forename: Davide
authors.initials: D
authors.lastname: Bizzoca
authors.forename: Pedro
authors.initials: P
authors.lastname: Berjano
authors.forename: Nunzia
authors.initials: N
authors.lastname: Garofalo
authors.forename: Stefania
authors.initials: S
authors.lastname: Setti
authors.forename: Franca
authors.initials: F
authors.lastname: Dicuonzo
authors.forename: Biagio
authors.initials: B
authors.lastname: Moretti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000473:pathology; D001855:Bone Marrow Diseases / Q000453:epidemiology* / Q000209:etiology*; D004487:Edema / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D050815:Fractures, Compression / Q000150:complications* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D016103:Spinal Fractures / Q000150:complications* / Q000628:therapy