title: Celecoxib Inhibits the Lytic Activation of Kaposi's Sarcoma-Associated Herpesvirus through Down-Regulation of RTA Expression by Inhibiting the Activation of p38 MAPK.
abstract: Kaposi's sarcoma associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV's lytic replication cycle is critical for the pathogenesis of KSHV-associated diseases. Despite recent progress in the development of treatments for KSHV associated malignancies, these therapies are not completely efficacious and cause side effects. Therefore, more effective therapies with antiviral agents against KSHV are urgently needed. In this study, we identified celecoxib as an antiviral agent against KSHV. Our data suggest that celecoxib inhibits the lytic activation of KSHV through the down-regulation of the expression of the lytic switch protein, replication and transcription activator (RTA), by inhibiting the activation of p38 MAPK. Therefore, celecoxib may provide a candidate inhibitor for the therapeutic research of KSHV-related malignancies.
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 43001, Hubei, China. cjgkaoyan@163.com.|University of Chinese Academy of Sciences, Beijing 100049, China. cjgkaoyan@163.com.
authors.forename: Jungang
authors.initials: J
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 43001, Hubei, China. jiangliangyu1988@126.com.|University of Chinese Academy of Sciences, Beijing 100049, China. jiangliangyu1988@126.com.
authors.forename: Liangyu
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. lanke@sibs.ac.cn.
authors.forename: Ke
authors.initials: K
authors.lastname: Lan
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 43001, Hubei, China. chenxl@wh.iov.cn.|University of Chinese Academy of Sciences, Beijing 100049, China. chenxl@wh.iov.cn.
authors.forename: Xulin
authors.initials: X
authors.lastname: Chen
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D000068579:Celecoxib / Q000494:pharmacology*; D015536:Down-Regulation; D015967:Gene Expression Regulation, Viral / Q000187:drug effects; D019288:Herpesvirus 8, Human / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000037:antagonists & inhibitors*; D015534:Trans-Activators / Q000037:antagonists & inhibitors*; D014775:Virus Activation / Q000187:drug effects*; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*
chemical_list: D000998:Antiviral Agents; D017874:Immediate-Early Proteins; C417604:Rta protein, Human herpesvirus 8; D015534:Trans-Activators; D048051:p38 Mitogen-Activated Protein Kinases; D000068579:Celecoxib