title: Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study.
abstract: OBJECTIVE
  Investigate the prevalence of osteoporosis in patients with systemic sclerosis (SSc) and describe alterations of bone tissue with High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT).
  
  
  METHODS
  Thirty-three patients and 33 controls matched on age, body mass index (BMI) and menopause were included. Bone mineral density (BMD) was measured at the lumbar spine (LS), femoral neck (FN) and total hip (TH) by dual energy X-ray absorptiometry. Volumetric BMD (vBMD) and bone microarchitecture were measured by HR-pQCT at tibia and radius.
  
  
  RESULTS
  In patients, BMI was significantly lower, the prevalence of osteoporosis was significantly higher and HR-pQCT analysis showed a significant alteration of the trabecular compartment with a decrease in trabecular vBMD on both sites than in controls. In multivariate analysis, a low lean body mass, presence of anticentromere antibodies and older age were identified as independent factors for decreased BMD at LS (r²=0.43), FN (r²=0.61) and TH (r²=0.73). History or current digital ulcers were also identified as an independent factor for microarchitecture alteration.
  
  
  CONCLUSIONS
  In patients an increased prevalence of osteoporosis was found and HR-pQCT showed impaired trabecular bone compartment. Also, low lean body mass, high age, digital ulcers and ACAs were identified as independent risk factors for bone damage.
authors.affiliation: Service de Rhumatologie, Centre Hospitalier Universitaire de Tours, France.|Service de Rhumatologie, Centre Hospitalier Régional d'Orléans, La Source, France.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Marot
authors.affiliation: Service du D.I.M., Centre Hospitalier Régional d'Orléans, La Source, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Valéry
authors.affiliation: Service de Dermatologie, Centre Hospitalier Régional d'Orléans, Porte Madeleine.
authors.forename: Eric
authors.initials: E
authors.lastname: Esteve
authors.affiliation: Service de Dermatologie, Centre Hospitalier Régional d'Orléans, Porte Madeleine.
authors.forename: Guido
authors.initials: G
authors.lastname: Bens
authors.affiliation: Service de Rhumatologie, Centre Hospitalier Régional d'Orléans, La Source, France.
authors.forename: Adelheid
authors.initials: A
authors.lastname: Müller
authors.affiliation: Service de Rhumatologie, Centre Hospitalier Régional d'Orléans, La Source, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Rist
authors.affiliation: Univ. Orléans, Orleans, France.|Service de Rhumatologie, Centre Hospitalier Régional d'Orléans, La Source, France.
authors.forename: Hechmi
authors.initials: H
authors.lastname: Toumi
authors.affiliation: Univ. Orléans, Orleans, France.|Service de Rhumatologie, Centre Hospitalier Régional d'Orléans, La Source, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Lespessailles
mesh_terms: D015502:Absorptiometry, Photon; D000367:Age Factors; D000368:Aged; D001323:Autoantibodies / Q000276:immunology; D015992:Body Mass Index; D015519:Bone Density; D016022:Case-Control Studies; D002503:Centromere / Q000276:immunology; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D015999:Multivariate Analysis; D010024:Osteoporosis / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D012595:Scleroderma, Systemic / Q000453:epidemiology*; D012883:Skin Ulcer / Q000453:epidemiology; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D001323:Autoantibodies
keywords: Gerotarget; chronic inflammatory; densitometry; osteopenia; rheumatic diseases; trabecular bone