title: Atg1 family kinases in autophagy initiation.
abstract: Autophagosome formation, a landmark event in autophagy, is accomplished by the concerted actions of Atg proteins. Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation. In this review, we summarize current knowledge of the structure, molecular function, and regulation of Atg1 family kinases in the initiation of autophagy.
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan, nn@bikaken.or.jp.
authors.forename: Nobuo N
authors.initials: NN
authors.lastname: Noda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Fujioka
mesh_terms: D000595:Amino Acid Sequence; D001343:Autophagy / Q000502:physiology*; D000071189:Autophagy-Related Protein-1 Homolog; D000071183:Autophagy-Related Proteins; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D013045:Species Specificity; D033921:Vesicular Transport Proteins / Q000378:metabolism
chemical_list: C543518:ATG101 protein, human; D000071183:Autophagy-Related Proteins; D047908:Intracellular Signaling Peptides and Proteins; C407704:RB1CC1 protein, human; D033921:Vesicular Transport Proteins; D011505:Protein-Tyrosine Kinases; D000071189:Autophagy-Related Protein-1 Homolog; D017346:Protein Serine-Threonine Kinases; C484754:ULK1 protein, human