title: IgA nephropathy and psoriatic arthritis that improved with steroid pulse therapy and mizoribine in combination with treatment for chronic tonsillitis and epipharyngitis.
abstract: A 65-year-old man was admitted to our hospital with edema and renal dysfunction. He had received a diagnosis of psoriatic arthritis at 50 years of age. As a renal biopsy showed IgA nephropathy (IgAN), bilateral tonsillectomy was performed, and one course of steroid pulse therapy with an oral steroid and mizoribine were subsequently administered. The patient's proteinuria gradually reduced in association with an improvement in the renal function. In addition, the rash and arthralgia were ameliorated. In this case, adding treatment for chronic epipharyngitis accelerated the curative effects, and focal infection therapy consisting of immunosuppressive drugs was effective for both IgAN and psoriatic arthritis.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Nippon Medical School, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kaneko
authors.forename: Akiko
authors.initials: A
authors.lastname: Mii
authors.forename: Megumi
authors.initials: M
authors.lastname: Fukui
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nagahama
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
authors.forename: Shuichi
authors.initials: S
authors.lastname: Tsuruoka
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D015535:Arthritis, Psoriatic / Q000188:drug therapy / Q000473:pathology*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D010612:Pharyngitis / Q000503:physiopathology; D011507:Proteinuria / Q000188:drug therapy*; D020551:Pulse Therapy, Drug / Q000379:methods*; D012263:Ribonucleosides / Q000627:therapeutic use*; D013256:Steroids / Q000627:therapeutic use*; D014069:Tonsillitis / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D012263:Ribonucleosides; D013256:Steroids; C010052:mizoribine