title: Occupational exposures and risk of dementia-related mortality in the prospective Netherlands Cohort Study.
abstract: BACKGROUND
  Occupational exposures may be associated with non-vascular dementia.
  
  
  METHODS
  We analyzed the effects of occupational exposures to solvents, pesticides, metals, extremely low frequency magnetic fields (ELF-MF), electrical shocks, and diesel motor exhaust on non-vascular dementia related mortality in the Netherlands Cohort Study (NLCS). Exposures were assigned using job-exposure matrices. After 17.3 years of follow-up, 682 male and 870 female cases were available. Analyses were performed using Cox regression.
  
  
  RESULTS
  Occupational exposure to metals, chlorinated solvents and ELF-MF showed positive associations with non-vascular dementia among men, which seemed driven by metals (hazard ratio ever high vs. background exposure: 1.35 [0.98-1.86]). Pesticide exposure showed statistically significant, inverse associations with non-vascular dementia among men. We found no associations for shocks, aromatic solvents, and diesel motor exhaust.
  
  
  CONCLUSIONS
  Consistent positive associations were found between occupational exposure to metals and non-vascular dementia. The finding on pesticides is not supported in the overall literature.
authors.affiliation: Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht.
authors.forename: Tom
authors.initials: T
authors.lastname: Koeman
authors.affiliation: Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht.
authors.forename: Leo J
authors.initials: LJ
authors.lastname: Schouten
authors.affiliation: Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht.
authors.forename: Piet A
authors.initials: PA
authors.lastname: van den Brandt
authors.affiliation: Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht.
authors.forename: Pauline
authors.initials: P
authors.lastname: Slottje
authors.affiliation: Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht.
authors.forename: Anke
authors.initials: A
authors.lastname: Huss
authors.affiliation: Occupational Respiratory Epidemiology, School of Population Health, University of Western Australia, Perth, Australia.
authors.forename: Susan
authors.initials: S
authors.lastname: Peters
authors.affiliation: Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht.
authors.forename: Hans
authors.initials: H
authors.lastname: Kromhout
authors.affiliation: Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Utrecht.|Julius Centre for Public Health Sciences and Primary Care, University Medical Center, Utrecht.
authors.forename: Roel
authors.initials: R
authors.lastname: Vermeulen
mesh_terms: D000368:Aged; D002423:Cause of Death; D003704:Dementia / Q000139:chemically induced / Q000401:mortality*; D005260:Female; D006801:Humans; D060526:Magnetic Fields / Q000009:adverse effects; D008297:Male; D008670:Metals / Q000633:toxicity; D008875:Middle Aged; D009426:Netherlands; D009784:Occupational Diseases / Q000139:chemically induced / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000633:toxicity; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012997:Solvents / Q000633:toxicity; D001335:Vehicle Emissions / Q000633:toxicity
chemical_list: D008670:Metals; D010575:Pesticides; D012997:Solvents; D001335:Vehicle Emissions
keywords: Alzheimer's disease; cohort; dementia; diesel motor exhaust; extremely low frequency magnetic fields; metals; occupation; pesticides; solvents