title: Biologically active and thermally stable polymeric Schiff base and its metal polychelates: Their synthesis and spectral aspects.
abstract: New metal polychelates of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) obtained by the interaction of metal acetates with polymeric Schiff base containing formaldehyde and piperazine, have been investigated. Structural and spectroscopic properties have been evaluated by elemental analysis, FT-IR and (1)H-NMR. Geometry of the chelated polymers was confirmed by magnetic susceptibility measurements, UV-Visible spectroscopy and Electron Spin Resonance. The molecular weight of the polymer was determined by gel permeation chromatography (GPC). Thermogravimetric analysis indicated that metal polychelates were more thermally stable than their corresponding ligand. All compounds were screened for their antimicrobial activities against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, (bacteria) and Candida albicans, Microsporum canis, Cryptococcus neoformans (fungi) by agar well diffusion method. Interestingly, the polymeric Schiff base was found to be antimicrobial in nature but less effective as compared to the metal polychelates. On the basis of thermal and antimicrobial behavior, these polymers hold potential applications as thermally resistant antimicrobial and antifouling coating materials as well as antimicrobial packaging materials.
authors.affiliation: Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India. Electronic address: razarasool@gmail.com.
authors.forename: Raza
authors.initials: R
authors.lastname: Rasool
authors.affiliation: Materials Research Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India.
authors.forename: Sumaiya
authors.initials: S
authors.lastname: Hasnain
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002614:Chelating Agents / Q000737:chemistry* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009181:Mycoses / Q000188:drug therapy; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D012545:Schiff Bases / Q000737:chemistry* / Q000494:pharmacology; D013818:Thermogravimetry
chemical_list: D000890:Anti-Infective Agents; D002614:Chelating Agents; D009942:Organometallic Compounds; D012545:Schiff Bases
keywords: Antimicrobial activity; Coordination polymers; Schiff base; Thermogravimetric analysis