title: Haunting the HOXA Locus: Two Faces of lncRNA Regulation.
abstract: Long non-coding RNAs (lncRNAs) regulate diverse biological functions through mechanisms ascribed to the lncRNA transcript itself. Now in Cell Stem Cell, Yin et al. (2015) use CRISPR/Cas9-mediated genome editing to demonstrate discrete and opposing roles for the lncRNA Haunt transcript and DNA at the HOXA locus during ESC differentiation.
authors.affiliation: Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.
authors.forename: Nianwei
authors.initials: N
authors.lastname: Lin
authors.affiliation: Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Dang
authors.affiliation: Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: trana@ucsd.edu.
authors.forename: Tariq M
authors.initials: TM
authors.lastname: Rana
mesh_terms: D000818:Animals; D053595:Embryonic Stem Cells / Q000502:physiology*; D018398:Homeodomain Proteins / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000378:metabolism*
chemical_list: D018398:Homeodomain Proteins; D062085:RNA, Long Noncoding