title: OARSI Clinical Trials Recommendations: Hip imaging in clinical trials in osteoarthritis.
abstract: Imaging of hip in osteoarthritis (OA) has seen considerable progress in the past decade, with the introduction of new techniques that may be more sensitive to structural disease changes. The purpose of this expert opinion, consensus driven recommendation is to provide detail on how to apply hip imaging in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for magnetic resonance imaging (MRI)); commonly encountered problems (including positioning, hardware and coil failures, artifacts associated with various MRI sequences); quality assurance/control procedures; measurement methods; measurement performance (reliability, responsiveness, and validity); recommendations for trials; and research recommendations.
authors.affiliation: Departments of Radiology, Bioengineering, and Orthopaedic Surgery, Stanford University, Stanford, CA, USA. Electronic address: gold@stanford.edu.
authors.forename: G E
authors.initials: GE
authors.lastname: Gold
authors.affiliation: School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne 3004, Australia.
authors.forename: F
authors.initials: F
authors.lastname: Cicuttini
authors.affiliation: Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, SP, Brazil.
authors.forename: M D
authors.initials: MD
authors.lastname: Crema
authors.affiliation: Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria & Chondrometrics GmbH, Ainring, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Eckstein
authors.affiliation: Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Guermazi
authors.affiliation: Department of Radiology, University of Wisconsin School of Medicine, Madison, WI, USA.
authors.forename: R
authors.initials: R
authors.lastname: Kijowski
authors.affiliation: Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Link
authors.affiliation: Rheumatology Department, Hôpital Saint-Antoine, AP-HP, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Maheu
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Martel-Pelletier
authors.affiliation: BioClinica, Newtown, PA, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Miller
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
authors.forename: J-P
authors.initials: JP
authors.lastname: Pelletier
authors.affiliation: Spire Sciences, Inc., Boca Raton, FL, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Peterfy
authors.affiliation: Department of Radiology, Hospital for Special Surgery, New York, NY, USA.
authors.forename: H G
authors.initials: HG
authors.lastname: Potter
authors.affiliation: Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, University of Erlangen-Nuremberg, Germany.
authors.forename: F W
authors.initials: FW
authors.lastname: Roemer
authors.affiliation: Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, NSW, Australia.
authors.forename: D J
authors.initials: DJ
authors.lastname: Hunter
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards*; D003952:Diagnostic Imaging / Q000592:standards*; D018450:Disease Progression; D006801:Humans; D015207:Osteoarthritis, Hip / Q000175:diagnosis*; D017410:Practice Guidelines as Topic
keywords: Clinical trial guidelines; Hip osteoarthritis; Imaging