title: Association analysis revealed one susceptibility locus for vitiligo with immune-related diseases in the Chinese Han population.
abstract: Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other immune-related diseases. However, there is no reported study on the associations between immune susceptibility polymorphisms and the risk of vitiligo with immune-related diseases. The aim of this study was to evaluate the potential influence of 10 single-nucleotide polymorphisms (SNPs) at 18q21.31 (rs10503019), 4p16.1 (rs11940117), 3q28 (rs1464510), 14q12 (rs2273844), 12q13.2 (rs2456973), 16q12.2 (rs3213758), 10q25.3 (rs4353229), 3q13.33 (rs59374417), and 10p15.1 (rs706779 and rs7090530) on vitiligo with immune-related diseases in the Chinese Han population. All SNPs were genotyped in 552 patients with vitiligo-associated immune-related diseases and 1656 controls using the Sequenom MassArray system. Data were analyzed with PLINK 1.07 software. The C allele of rs2456973 at 12q13.2 was observed to be significantly associated with vitiligo-associated immune-related diseases (autoimmune diseases and allergic diseases) (P = 0.0028, odds ratio (OR) = 1.27). In subphenotype analysis, the rs2456973 C allele was also significantly associated with early-onset vitiligo by comparing with controls (P = 0.0001) and in the case-only analysis (P = 0.0114). We confirmed that 12q13.2 was an important candidate locus for vitiligo with immune-related diseases (autoimmune diseases and allergic diseases) and affected disease phenotypes with early onset.
authors.affiliation: Institute of Dermatology & Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Li
authors.forename: Weiyi
authors.initials: W
authors.lastname: Yao
authors.forename: Qian
authors.initials: Q
authors.lastname: Pan
authors.forename: Xianfa
authors.initials: X
authors.lastname: Tang
authors.forename: Suli
authors.initials: S
authors.lastname: Zhao
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Zhu
authors.forename: Jinping
authors.initials: J
authors.lastname: Gao
authors.forename: Yujun
authors.initials: Y
authors.lastname: Sheng
authors.forename: Fusheng
authors.initials: F
authors.lastname: Zhou
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zheng
authors.forename: Xianbo
authors.initials: X
authors.lastname: Zuo
authors.forename: Liangdan
authors.initials: L
authors.lastname: Sun
authors.forename: Anping
authors.initials: A
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D001327:Autoimmune Diseases / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D014820:Vitiligo / Q000235:genetics*