title: [Effect of electro-acupuncture on the spindle and oocytes quality in patients with PCOS].
abstract: OBJECTIVE
  To observe the effect of electro-acupuncture (EA) treatment on the oocyte quality in polycystic ovarian syndrome (PCOS) patients undergoing in vitro fertilization-embryo transfer (IVF-ET).
  
  
  METHODS
  Totally 217 PCOS patients undergoing IVF-ET were assigned to two groups by random digit table, the EA group (119 cases) and the control group (98 cases). All patients received long program ovarian hyperstimulation with gonadotropin-releasing hormone agonist. Patients in the EA group received EA treatment in the process of controlled ovarian hyperstimulation till the oocyte retrieval day. The position relation of the spindle to the polocyte, the number of retrieved oocytes, the fertilization rate,the cleavage rate,the high quality embryo rate, the ovarian hyperstimulation syndrome (OHSS) incidence rate, the clinical pregnancy rate, the early abortion rate, the gonadotropins (Gn) dose and time, levels of estradiol (E2), progesterone (P), and luteinizing hormone (LH) on the day of human chorionic gonadotropin (HCG) were observed between the two groups.
  
  
  RESULTS
  The ratio of oocytes in which the meiotic spindle deviation angle was < 60 degrees to the all oocytes was obviously higher in the EA group than in the control group (P < 0.05). The oocytes in which the meiotic spindle deviation angle was < 60 degrees was positively related to level of E2 on the HCG day and the high quality embryo rate (r = 0.19,P < 0.01). Compared with the control group, the high quality embryo rate increased significantly (P < 0.05), the dose and days of Gn decreased significantly (P < 0.05) in the EA group. The clinical pregnancy rate was improved by 8.36%.
  
  
  CONCLUSIONS
  The spindle was positively correlated with the oocyte quality. EA could improve the quality of oocytes and the clinical pregnancy rate in PCOS patients undergoing IVF-ET.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Qi-Yao
authors.initials: QY
authors.lastname: Zhang
authors.forename: Qun
authors.initials: Q
authors.lastname: Guan
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D004624:Embryo Transfer; D004958:Estradiol; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone; D006062:Gonadotropins; D006801:Humans; D007986:Luteinizing Hormone; D009865:Oocytes; D016471:Ovarian Hyperstimulation Syndrome; D011085:Polycystic Ovary Syndrome / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone
chemical_list: D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone