title: Correlation of disease activity and serum level of carcinoembryonic antigen in acquired idiopathic generalized anhidrosis: A case report.
abstract: Hypohidrosis and anhidrosis are congenital or acquired conditions which are characterized by inadequate sweating. Acquired idiopathic generalized hypohidrosis/anhidrosis (AIGA) includes idiopathic pure sudomotor failure (IPSF), which has the following distinct features: sudden onset in youth, increased serum immunoglobulin E and responds favorably to systemic corticosteroid. No clinical markers reflecting the disease severity or activity have been established. Here, we report a case of AIGA in a Japanese patient successfully treated with repeated methylprednisolone pulse therapy. In this case, serum carcinoembryonic antigen (CEA) levels increased up to 19.8 ng/mL along with aberrant CEA immunoreactivity of eccrine sweat glands. Interestingly, the serum CEA level normalized as sweating improved with repeated methylprednisolone pulse therapy. Therefore, serum CEA level may serve as a useful clinical marker of hypohidrosis or anhidrosis.
authors.affiliation: Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Honma
authors.affiliation: Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Iinuma
authors.affiliation: Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kanno
authors.affiliation: Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Shigetsuna
authors.initials: S
authors.lastname: Komatsu
authors.affiliation: Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Minami-Hori
authors.affiliation: Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Ishida-Yamamoto
mesh_terms: D000328:Adult; D002272:Carcinoembryonic Antigen / Q000097:blood*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007007:Hypohidrosis / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D008775:Methylprednisolone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug
chemical_list: D002272:Carcinoembryonic Antigen; D005938:Glucocorticoids; D008775:Methylprednisolone
keywords: anhidrosis; carcinoembryonic antigen; carcinoembryonic antigen-related cell adhesion molecule; clinical marker; hypohidrosis; sweat gland