title: Prussian Blue Derived Nanoporous Iron Oxides as Anticancer Drug Carriers for Magnetic-Guided Chemotherapy.
abstract: New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug-delivery systems (DDS) of bladder cancer cells (i.e., T24) with controlled release and magnetic guiding properties. The results of the MTT assay and confocal laser scanning microscopy indicate that the synthesized iron oxide nanoparticles were successfully uptaken by T24 cells with excellent biocompatibility. An anticancer drug, that is, cisplatin, was used as a model drug, and its loading/release behavior was investigated. The intracellular drug delivery efficiency was greatly enhanced for the cisplatin-loaded, PB-derived, magnetic-guided drug-delivery system compared with the non-drug case. The synthesized nanomaterials show great potential as drug vehicles with high biocompatibility, controlled release, and magnetic targeting features for future intracellular DDS.
authors.affiliation: Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan.|World Premier International (WPI) Research Center for Materials, Nanoarchitechtonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.|Department of Chemistry, Faculty of Science, Tanta University, Tanta, Gharbeya, 31527, Egypt.
authors.forename: Mohamed B
authors.initials: MB
authors.lastname: Zakaria
authors.affiliation: World Premier International (WPI) Research Center for Materials, Nanoarchitechtonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
authors.forename: Alexei A
authors.initials: AA
authors.lastname: Belik
authors.affiliation: Department of Urology, Taipei Medical University-Shuang Ho Hospital, No. 291, Jhongjheng Rd., Jhonghe Dist., New Taipei City, 23561, Taiwan.
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Liu
authors.affiliation: Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 10617, Taiwan.
authors.forename: Han-Yun
authors.initials: HY
authors.lastname: Hsieh
authors.affiliation: Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 10617, Taiwan.
authors.forename: Yu-Te
authors.initials: YT
authors.lastname: Liao
authors.affiliation: World Premier International (WPI) Research Center for Materials, Nanoarchitechtonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
authors.forename: Victor
authors.initials: V
authors.lastname: Malgras
authors.affiliation: Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan. Yamauchi.Yusuke@nims.go.jp.|World Premier International (WPI) Research Center for Materials, Nanoarchitechtonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan. Yamauchi.Yusuke@nims.go.jp.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yamauchi
authors.affiliation: Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 10617, Taiwan. kevinwu@ntu.edu.tw.|Division of Medical Engineering Research, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan. kevinwu@ntu.edu.tw.
authors.forename: Kevin C-W
authors.initials: KC
authors.lastname: Wu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry*; D005295:Ferrocyanides / Q000737:chemistry*; D006801:Humans; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D016062:Porosity; D001743:Urinary Bladder / Q000187:drug effects / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005290:Ferric Compounds; D005295:Ferrocyanides; D058185:Magnetite Nanoparticles; C000499:ferric oxide; D002945:Cisplatin; C000170:ferric ferrocyanide
keywords: Prussian blue; drug delivery; iron oxide; magnetic-guided chemotherapy; nanoparticles