title: Migration of Transformed Bone Marrow-Derived Cells with Peripheral Neural Tumor Traits In Vivo.
abstract: The identification of the original cells in tumors may allow for measures that protect the original cells and prevent tumor formation. In the present study, we isolated a subpopulation of cells with the features of neural tumor cells from transformed BMDCs in vitro. These neural tumor cells expressed the markers of neural tumor progenitor cells and differentiated neural tumor cells in vitro. Moreover, the subcloned cells from transformed BMDCs could migrate to distant tissues and drive peripheral neural tumors in vivo. Therefore, our results further verify that transformed mouse BMDCs are a potential source of peripheral neural tumors.
authors.affiliation: a Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College , Fudan University , Shanghai , China.
authors.forename: Chunfang
authors.initials: C
authors.lastname: Liu
authors.affiliation: a Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College , Fudan University , Shanghai , China.
authors.forename: Jinghui
authors.initials: J
authors.lastname: Hu
authors.affiliation: a Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College , Fudan University , Shanghai , China.
authors.forename: Ruilai
authors.initials: R
authors.lastname: Liu
authors.affiliation: a Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College , Fudan University , Shanghai , China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Liu
authors.affiliation: a Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College , Fudan University , Shanghai , China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.affiliation: b Department of Laboratory Medicine, Shanghai Children's Hospital , Shanghai Jiao Tong University , Shanghai , China.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Ma
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology*; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D005260:Female; D008297:Male; D008819:Mice, Nude; D009380:Neoplasms, Nerve Tissue / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology*; D017253:Neurofibromatoses / Q000473:pathology; D023041:Xenograft Model Antitumor Assays
keywords: Bone marrow-derived cells (BMDCs); Migration; Neural tumor progenitor cells; Peripheral neural tumors; Source of tumor; Transformation