title: Association between Apolipoprotein E Variants and Obesity-Related Traits in Mexican School Children.
abstract: OBJECTIVE
  Genetic variation in apolipoprotein E (ApoE) has a key role in lipid metabolism. However, its contribution to the amount and distribution of body fat is under investigation. The aim of this study was to analyze the association between genetic variation in ApoE and obesity-related traits in Mexican school children.
  
  
  METHODS
  Anthropometric, body composition and physical activity measures were conducted using standard methods in 300 children (177 girls/123 boys) who fulfilled the inclusion criteria. DNA was isolated from saliva. ApoE genotypes were analyzed by allelic discrimination. The association between variation in ApoE and anthropometric and body composition measures was investigated using the General Linear Model.
  
  
  RESULTS
  The mean±SD values for age, body mass index (BMI) and waist circumference (WC) were 9.05±0.80 years, 19.01±3.83 and 67.98±10.97 cm, respectively. Approximately 46% of the participants were overweight or obese. A significant association between ApoE isoforms and WC was found after controlling for age, sex and the percentage of physical activity (p=0.025). Significant main effects were found for vigorous physical activity and light physical activity influencing the adiposity-related BMI (p<0.001) and WC (p=0.044), respectively.
  
  
  CONCLUSIONS
  Variation in ApoE and physical activity intensity were associated with adiposity-related phenotypes in Mexican school children.
authors.affiliation: Universidad Autónoma Metropolitana, Mexico City, Mexico.
authors.forename: Yanelli
authors.initials: Y
authors.lastname: Rodríguez-Carmona
authors.forename: Marcela
authors.initials: M
authors.lastname: Pérez-Rodríguez
authors.forename: Eli
authors.initials: E
authors.lastname: Gámez-Valdez
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: López-Alavez
authors.forename: Claudia I
authors.initials: CI
authors.lastname: Hernández-Armenta
authors.forename: Norma
authors.initials: N
authors.lastname: Vega-Monter
authors.forename: Gerardo
authors.initials: G
authors.lastname: Leyva-García
authors.forename: Tulia
authors.initials: T
authors.lastname: Monge-Cázares
authors.forename: Daniela
authors.initials: D
authors.lastname: Barrera Valencia
authors.forename: Marisol
authors.initials: M
authors.lastname: Balderas Monroy
authors.forename: Frania
authors.initials: F
authors.lastname: Pfeffer
authors.forename: Guillermo
authors.initials: G
authors.lastname: Meléndez
authors.forename: Ana Bertha
authors.initials: AB
authors.lastname: Pérez Lizaur
authors.forename: Jeanette
authors.initials: J
authors.lastname: Pardío
authors.forename: María Elizabeth
authors.initials: ME
authors.lastname: Tejero
mesh_terms: D053329:Apolipoprotein E2 / Q000235:genetics; D053318:Apolipoprotein E3 / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008800:Mexico; D009043:Motor Activity; D054647:Nutrigenomics; D009752:Nutritional Status; D009765:Obesity / Q000097:blood* / Q000235:genetics* / Q000473:pathology; D011446:Prospective Studies; D055105:Waist Circumference
chemical_list: D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E