title: [Clinical significance of bone marrow morphological examination and tumor marker detection for lymphoma diagnosis and prognosis].
abstract: OBJECTIVE
  This study was aimed to evaluate the significance of bone marrow(BM) morphological examination and many tumor marker(TM) detection, especially carcinoembryonic antigen (CEA), cancer antigen 125(CA125), cancer antigen 15-3 (CA15-3) and serum ferritin (SF) for lymphoma diagnosis and prognosis.
  
  
  METHODS
  A total of 47 confirmed patients with lymphoma in our hospital from January 2012 to October 2013 and 20 health peoplels as normal controls were performed with bone marrow morphological examination, at the same time, the electrochemistry luminescent technique was applied for detecting levels of TM (especially CEA, CA125, CA15-3 and SF) in serum samples of lymphoma patient and normal controls, then the BM immature lymphocyte counts of these people and clinical parameters were analyzed for diagnosis and prognosis.
  
  
  RESULTS
  There was significant differences in all the four TM levels between serum samples of lymphoma patients and normal control (P=0.029, P=0.000, P=0.005, P=0.000). These TM levels had no correlation with age, sex white blood cell, lymphocyte, platelet counts and anemia of lymphoma patients (P>0.05). It was also found that the patients with elevated TM levels had high BM immature lymphocytes (lymphoma cells) counts, B symptoms, advanced clinical stage and high IPI index (P<0.05). The CA15-3 and SF levels in serum samples of lymphoma patients with BM infiltration were higher than that in lymphoma patients without BM infiltration (P=0.002, P=0.000).
  
  
  CONCLUSIONS
  Combination of BM morphological examination with serum TM level detection plays an important role in diagnosis, clinical stage and prognosis evaluation of lymphoma patients. It is also very important for assessing BM infiltration status of lymphoma patients.
authors.affiliation: Department of Clinical Laboratorial Examination, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Hui-Yuan
authors.initials: HY
authors.lastname: Kang
authors.affiliation: Department of Clinical Laboratorial Examination, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Clinical Laboratorial Examination, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Shu-Yuan
authors.initials: SY
authors.lastname: Jin
authors.affiliation: Department of Clinical Laboratorial Examination, Chinese PLA General Hospital, Beijing 100853, China. E-mail: limianyang301@163.com.
authors.forename: Mian-Yang
authors.initials: MY
authors.lastname: Li
authors.affiliation: Department of Clinical Laboratorial Examination, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Pan
authors.affiliation: Department of Clinical Laboratorial Examination, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Gai-Xia
authors.initials: GX
authors.lastname: Liu
authors.affiliation: Department of Clinical Laboratorial Examination, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Xiao-Qian
authors.initials: XQ
authors.lastname: Feng
authors.affiliation: Department of Clinical Laboratorial Examination, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Cheng-Bin
authors.initials: CB
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor; D001853:Bone Marrow; D001856:Bone Marrow Examination; D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; D006801:Humans; D008223:Lymphoma; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen