title: Stroke genomics in people of African ancestry: charting new paths.
abstract: One in six people worldwide will experience a stroke in his/her lifetime. While people in Africa carry a disproportionately higher burden of poor stroke outcomes, compared to the rest of the world, the exact contribution of genomic factors to this disparity is unknown. Despite noteworthy research into stroke genomics, studies exploring the genetic contribution to stroke among populations of African ancestry in the United States are few. Furthermore, genomics data in populations living in Africa are lacking. The wide genomic variation of African populations offers a unique opportunity to identify genomic variants with causal relationships to stroke across different ethnic groups. The Stroke Investigative Research and Educational Network (SIREN), a component of the Human Health and Heredity in Africa (H3Africa) Consortium, aims to explore genomic and environmental risk factors for stroke in populations of African ancestry in West Africa and the United States. In this article, we review the literature on the genomics of stroke with particular emphasis on populations of African origin.
authors.affiliation: Division of Neurology, Federal Medical Centre Abeokuta, Nigeria; Institute of Neuroscience, Newcastle University, UK.
authors.forename: R O
authors.initials: RO
authors.lastname: Akinyemi
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, USA.
authors.forename: B
authors.initials: B
authors.lastname: Ovbiagele
authors.affiliation: College of Health Sciences, University of Ghana, Accra, Ghana.
authors.forename: A
authors.initials: A
authors.lastname: Akpalu
authors.forename: C
authors.initials: C
authors.lastname: Jenkins
authors.affiliation: College of Health Sciences, University of Ghana, Accra, Ghana.
authors.forename: K
authors.initials: K
authors.lastname: Sagoe
authors.affiliation: Department of Medicine, Bayero University, Kano, Nigeria.
authors.forename: L
authors.initials: L
authors.lastname: Owolabi
authors.affiliation: School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
authors.forename: F
authors.initials: F
authors.lastname: Sarfo
authors.affiliation: Department of Medicine, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: R
authors.initials: R
authors.lastname: Obiako
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, USA.
authors.forename: M
authors.initials: M
authors.lastname: Gebreziabher
authors.affiliation: College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: E
authors.initials: E
authors.lastname: Melikam
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, USA.
authors.forename: S
authors.initials: S
authors.lastname: Warth
authors.affiliation: College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: O
authors.initials: O
authors.lastname: Arulogun
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, USA.
authors.forename: D
authors.initials: D
authors.lastname: Lackland
authors.affiliation: College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: A
authors.initials: A
authors.lastname: Ogunniyi
authors.affiliation: Department of Public Health, University of Alabama at Birmingham, USA.
authors.forename: H
authors.initials: H
authors.lastname: Tiwari
authors.affiliation: Institute of Neuroscience, Newcastle University, UK.
authors.forename: R N
authors.initials: RN
authors.lastname: Kalaria
authors.affiliation: Department of Public Health, University of Alabama at Birmingham, USA.
authors.forename: D
authors.initials: D
authors.lastname: Arnett
authors.affiliation: College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: M O
authors.initials: MO
authors.lastname: Owolabi
mesh_terms: D000349:Africa; D044383:Black People / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D023281:Genomics; D006801:Humans; D012307:Risk Factors; D020521:Stroke / Q000235:genetics* / Q000628:therapy*