title: Rhodium(II)-catalysed intramolecular C-H insertion α- to oxygen: reactivity, selectivity and applications to natural product synthesis.
abstract: The selective functionalisation of C-H bonds is a powerful strategy for the construction of organic molecules and the Rh(II)-catalysed C-H insertion reaction is a particularly robust and useful tool for this purpose. This review discusses the insertion of Rh(II) carbenes into C-H bonds that are activated by α-oxygen substituents, focusing on the trends that have been observed in reactivity and selectivity, and the applications of this reaction to the total synthesis of complex natural products.
authors.affiliation: Eskitis Institute for Drug Discovery, Griffith University, Don Young Rd, Nathan, Queensland 4111, Australia. m.coster@griffith.edu.au.
authors.forename: Fanny J
authors.initials: FJ
authors.lastname: Lombard
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Coster
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D006859:Hydrogen / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D007783:Lactones; D002244:Carbon; D006859:Hydrogen; D012238:Rhodium; D010100:Oxygen