title: Participation of hMLH1, p63, and MDM2 proteins in the pathogenesis of syndromic and nonsyndromic keratocystic odontogenic tumors.
abstract: OBJECTIVE
  To evaluate the expression of hMLH1, p63, and MDM2 in Gorlin syndrome-associated keratocystic odontogenic tumors (SKOTs) and nonsyndromic keratocystic odontogenic tumors (NSKOTs).
  
  
  METHODS
  Seventeen primary NSKOTs, 17 SKOTs, and 8 recurrent NSKOTs were analyzed by using immunohistochemistry.
  
  
  RESULTS
  No significant differences in the hMLH1, p63, or MDM2 labeling indices were observed between groups (P = .398; P = .232; P = .426, respectively). Higher hMLH1 immunoexpression was found in the basal layer of primary NSKOTs. Most KOTs exhibited p63 immunoexpression in the upper layers of the epithelium. MDM2 immunoexpression was observed in the upper epithelial layers of SKOTs and recurrent NSKOTs.
  
  
  CONCLUSIONS
  It was not possible to correlate the immunoexpression of hMLH1, p63, and MDM2 in SKOTs and primary and recurrent NSKOTs, suggesting that these proteins exert independent effects on the development of these groups of tumors.
authors.affiliation: Postgraduate Program of Oral Pathology, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
authors.forename: Bárbara Vanessa
authors.initials: BV
authors.lastname: de Brito Monteiro
authors.affiliation: Department of Oral Pathology, University of Fortaleza, Fortaleza, Ceara, Brazil.
authors.forename: Roberta Barroso
authors.initials: RB
authors.lastname: Cavalcante
authors.affiliation: Department of Oral Surgery, Federal University of Ceara, Fortaleza, Ceara, Brazil.
authors.forename: Renato Luiz
authors.initials: RL
authors.lastname: Maia Nogueira
authors.affiliation: Postgraduate Program of Oral Pathology, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
authors.forename: Márcia Cristina
authors.initials: MC
authors.lastname: da Costa Miguel
authors.affiliation: Postgraduate Program of Dentistry, Department of Dentistry, State University of Paraiba, Campina Grande, Paraiba, Brazil.
authors.forename: Cassiano Francisco
authors.initials: CF
authors.lastname: Weege Nonaka
authors.affiliation: Postgraduate Program of Oral Pathology, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address: Ericka_janine@yahoo.com.br.
authors.forename: Éricka Janine Dantas
authors.initials: ÉJ
authors.lastname: da Silveira
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D001478:Basal Cell Nevus Syndrome / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D000070957:MutL Protein Homolog 1; D009687:Nuclear Proteins / Q000378:metabolism*; D009808:Odontogenic Tumors / Q000378:metabolism* / Q000473:pathology*; D051736:Proto-Oncogene Proteins c-mdm2 / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C501486:MLH1 protein, human; D009687:Nuclear Proteins; C115051:TP63 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D000070957:MutL Protein Homolog 1