title: [Redox Molecular Imaging Using ReMI].
abstract: Tissue redox status is one of the most important parameters to maintain homeostasis in the living body. Numerous redox reactions are involved in metabolic processes, such as energy production in the mitochondrial electron transfer system. A variety of intracellular molecules such as reactive oxygen species, glutathione, thioredoxins, NADPH, flavins, and ascorbic acid may contribute to the overall redox status in tissues. Breakdown of redox balance may lead to oxidative stress and can induce many pathological conditions such as cancer, neurological disorders, and aging. Therefore imaging of tissue redox status and monitoring antioxidant levels in living organisms can be useful in the diagnosis of disease states and assessment of treatment response. In vivo redox molecular imaging technology such as electron spin resonance imaging (ESRI), magnetic resonance imaging (MRI), and dynamic nuclear polarization (DNP)-MRI (redox molecular imaging; ReMI) is emerging as a viable redox status imaging modality. This review focuses on the application of magnetic resonance technologies using MRI or DNP-MRI and redox-sensitive contrast agents.
authors.affiliation: Innovation Center for Medical Redox Navigation, Kyushu University.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Hyodo
authors.forename: Shinji
authors.initials: S
authors.lastname: Ito
authors.forename: Hideo
authors.initials: H
authors.lastname: Utsumi
mesh_terms: D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D003287:Contrast Media; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals / Q000032:analysis; D006706:Homeostasis; D006801:Humans; D008279:Magnetic Resonance Imaging; D057054:Molecular Imaging / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000175:diagnosis; D009422:Nervous System Diseases / Q000175:diagnosis; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D003287:Contrast Media; D005609:Free Radicals