title: β-asarone from Acorus gramineus alleviates depression by modulating MKP-1.
abstract: In this study, we investigated the antidepressant effects of hippocampal neuron administration of β-asarone, a selective mitogen-activated protein kinase phosphatase-1 inhibitor, in a rat model of depression. Our previous studies showed that the extracellular signal-regulated kinase signaling pathway and brain-derived neurotrophic factor expression, which is regulated by extracellular signal-regulated kinase, are key links in the biological mechanism of depression. Mitogen-activated protein kinase phosphatase-1 (MKP-1) is a negative regulatory protein of extracellular signal-regulated kinase signaling pathways. In this study, we explored the regulation of MKP-1 by β-asarone in producing an antidepressant effect.
authors.affiliation: Department of Pathology Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: Y R
authors.initials: YR
authors.lastname: Sun
authors.affiliation: Department of Pathology Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Department of Pathology Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: S S
authors.initials: SS
authors.lastname: Li
authors.affiliation: Department of Pathology Qiqihar Medical University, Qiqihar, Heilongjiang Province, China.
authors.forename: H Y
authors.initials: HY
authors.lastname: Dong
authors.affiliation: Department of Pathology Qiqihar Medical University, Qiqihar, Heilongjiang Province, China qqhemu_zxj@126.com.
authors.forename: X J
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D029023:Acorus; D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D054638:Dual Specificity Phosphatase 1 / Q000037:antagonists & inhibitors* / Q000235:genetics; D015870:Gene Expression; D008297:Male; D051381:Rats; D015398:Signal Transduction
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000928:Antidepressive Agents; C012195:asarone; C517019:DUSP1 protein, human; D054638:Dual Specificity Phosphatase 1