title: An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies.
abstract: A new anticancer agent based on the conjugation of a photoactivatable Pt(IV) pro-drug to a cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was induced preferentially in SK-MEL-28 melanoma cancer cells overexpressing αVβ3 integrin compared to control DU-145 human prostate carcinoma cells.
authors.affiliation: Departament de Química Orgànica and IBUB, Universitat de Barcelona, Barcelona, E-08028, Spain. vmarchan@ub.edu.
authors.forename: Albert
authors.initials: A
authors.lastname: Gandioso
authors.forename: Evyenia
authors.initials: E
authors.lastname: Shaili
authors.forename: Anna
authors.initials: A
authors.lastname: Massaguer
authors.forename: Gerard
authors.initials: G
authors.lastname: Artigas
authors.forename: Alejandro
authors.initials: A
authors.lastname: González-Cantó
authors.forename: Julie A
authors.initials: JA
authors.lastname: Woods
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Sadler
authors.forename: Vicente
authors.initials: V
authors.lastname: Marchán
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D045744:Cell Line, Tumor; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D008027:Light; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D010984:Platinum / Q000378:metabolism; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D019030:Receptors, Vitronectin / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D039302:Integrin alphaVbeta3; D009944:Organoplatinum Compounds; D010456:Peptides, Cyclic; D011355:Prodrugs; D019030:Receptors, Vitronectin; C064660:integrin alphaVbeta5; D010984:Platinum