title: Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury.
abstract: Weanling male Wistar rats fed a choline-deficient diet develop acute kidney injury. Menhaden oil, which is a very important source of omega-3 fatty acids, has a notorious protective effect. The mechanism of this protection is unknown; one possibility could be that menhaden oil changes renal lipid profile, with an impact on the functions of biological membranes. The aim of this work was to study the renal lipid profile in rats fed a choline-deficient diet with menhaden oil or vegetable oil as lipids. Rats were divided into 4 groups and fed four different diets for 7 days: choline-deficient or choline-supplemented diets with corn and hydrogenated oils or menhaden oil. Serum homocysteine, vitamin B12, and folic acid were analyzed. Renal lipid profile, as well as the fatty acid composition of the three oils, was measured. Choline-deficient rats fed vegetable oils showed renal cortical necrosis. Renal omega-6 fatty acids were higher in rats fed a cholinedeficient diet and a choline-supplemented diet with vegetable oils, while renal omega-3 fatty acids were higher in rats fed a choline-deficient diet and a choline-supplemented diet with menhaden oil. Rats fed menhaden oil diets had higher levels of renal eicosapentaenoic and docosahexaenoic acids. Renal myristic acid was increased in rats fed menhaden oil. The lipid renal profile varied quickly according to the type of oil present in the diet.
authors.affiliation: Centro de Patología Experimental y Aplicada, Departamento de Patología, Facultad de Medicina, Universidad de Buenos Aires.
authors.forename: Georgina P
authors.initials: GP
authors.lastname: Ossani
authors.forename: Valeria C
authors.initials: VC
authors.lastname: Denninghoff
authors.forename: Ana M
authors.initials: AM
authors.lastname: Uceda
authors.forename: Maria L
authors.initials: ML
authors.lastname: Díaz
authors.forename: Raúl
authors.initials: R
authors.lastname: Uicich
authors.forename: Alberto J
authors.initials: AJ
authors.lastname: Monserrat
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D002794:Choline / Q000008:administration & dosage; D002796:Choline Deficiency / Q000150:complications; D004195:Disease Models, Animal; D004281:Docosahexaenoic Acids / Q000378:metabolism; D015118:Eicosapentaenoic Acid / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology*; D005395:Fish Oils / Q000008:administration & dosage* / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D019814:Myristic Acid / Q000378:metabolism; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D017208:Rats, Wistar
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D010938:Plant Oils; D019814:Myristic Acid; C033266:Menhaden oil; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid; D002794:Choline