title: Rotigotine Transdermal Patch Improves Swallowing in Dysphagic Patients with Parkinson's Disease.
abstract: Abnormal swallowing, dysphagia, is a potentially fatal symptom in Parkinson's disease (PD) and is characterized by frequent silent aspiration, an unrecognized risk of suffocation and aspiration pneumonia. Several studies have reported that the injection of apomorphine, a dopamine agonist, alleviated dysphagia in some patients with PD. The effects of other antiparkinson medications against dysphagia remain controversial. Rotigotine is another dopamine agonist with non-oral administration, i.e., a transdermal patch. Its noninvasiveness seems to render this medicine even more suitable than apomorphine for dysphasic patients. However, no direct evidence has been reported. In the present retrospective open-label study, we for the first time objectively showed that rotigotine improved swallowing on videofluoroscopic examination in dysphagic patients with PD.
authors.affiliation: Department of Neurology, Sakai Hospital Kinki University Faculty of Medicine, 2-7-1 Harayamadai, Minami-ku, Sakai, Osaka, 590-0132, Japan, hirano_makito@yahoo.co.jp.
authors.forename: Makito
authors.initials: M
authors.lastname: Hirano
authors.forename: Chiharu
authors.initials: C
authors.lastname: Isono
authors.forename: Hikaru
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ueno
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D000369:Aged, 80 and over; D003679:Deglutition / Q000187:drug effects*; D003680:Deglutition Disorders / Q000209:etiology* / Q000503:physiopathology*; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy*; D012189:Retrospective Studies; D013764:Tetrahydronaphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D013876:Thiophenes / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D018491:Dopamine Agonists; D013764:Tetrahydronaphthalenes; D013876:Thiophenes; C047508:rotigotine