title: Usefulness of a Simple Clinical Risk Prediction Method, Modified ACEF Score, for Transcatheter Aortic Valve Implantation.
abstract: BACKGROUND
  We assessed the predictive accuracy of a simple risk score, modified age, creatinine clearance, ejection fraction (ACEFmodif) score, for outcome of transcatheter aortic valve implantation (TAVI).
  
  
  RESULTS
  We prospectively included 703 consecutive patients undergoing TAVI. Patients were divided into low, middle and high ACEFmodif tertiles. Increased ACEFmodif score was associated with a significantly higher 1-year mortality rate (22%, 28% and 36%, P<0.01) and higher risk of acute kidney injury (AKI; 10%, 10% and 22%, P<0.01). On multivariate logistic regression analysis, ACEFmodif score was the only independent predictor of AKI. On multivariate Cox regression, ACEFmodif score was an independent predictor of 1-year cumulative mortality. Although the area under curve (AUC) showed that all risk scores poorly predicted the incidence of AKI and 1-year cumulative mortality, ACEFmodif score was more efficient in predicting the incidence of AKI compared with STS, LES and ES II (AUC, 0.61, 0.55, 0.54, 0.57, respectively). Furthermore, ACEFmodif score had similar accuracy in predicting 1-year mortality compared with other risk scores (AUC, 0.61, 0.61, 0.61, 0.61, respectively).
  
  
  CONCLUSIONS
  ACEFmodif score may provide useful information for predicting AKI, 30-day and 1-year mortality in patients undergoing TAVI, but these results need further confirmation.
authors.affiliation: Department of Interventional Cardiology, Institut Cardiovasculaire Paris Sud.
authors.forename: Takahide
authors.initials: T
authors.lastname: Arai
authors.forename: Thierry
authors.initials: T
authors.lastname: Lefèvre
authors.forename: Kentaro
authors.initials: K
authors.lastname: Hayashida
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Stephen A
authors.initials: SA
authors.lastname: O'Connor
authors.forename: Thomas
authors.initials: T
authors.lastname: Hovasse
authors.forename: Mauro
authors.initials: M
authors.lastname: Romano
authors.forename: Philippe
authors.initials: P
authors.lastname: Garot
authors.forename: Erik
authors.initials: E
authors.lastname: Bouvier
authors.forename: Bernard
authors.initials: B
authors.lastname: Chevalier
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Morice
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology / Q000401:mortality; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000097:blood / Q000401:mortality; D011446:Prospective Studies; D012307:Risk Factors; D013318:Stroke Volume; D015996:Survival Rate; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects*
chemical_list: D003404:Creatinine