title: Mn2+-doped prussian blue nanocubes for bimodal imaging and photothermal therapy with enhanced performance.
abstract: Prussian blue (PB) as a clinically adapted agent recently has drawn much attention in cancer theranostics for potential applications in magnetic resonance (MR) imaging as well as photothermal cancer treatment. In this work, we take a closer look at the imaging and therapy performance of PB agents once they are doped with Mn2+. It is found that Mn2+-doped PB nanocubes exhibit increased longitudinal relaxivity along with enhanced optical absorption red-shifted to the near-infrared (NIR) region. Those properties make PB:Mn nanocubes with appropriate surface coatings rather attractive agents for biomedical imaging and cancer therapy, which have been successfully demonstrated in our in vivo experiments for effectively tumor ablation.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhu
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Sun
authors.affiliation: §Department of Radiology the First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: §Department of Radiology the First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D005295:Ferrocyanides / Q000737:chemistry / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008345:Manganese / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry; D000068936:Theranostic Nanomedicine / Q000379:methods; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D005295:Ferrocyanides; D053769:Nanocapsules; D017319:Photosensitizing Agents; D008345:Manganese; C000170:ferric ferrocyanide
keywords: MR imaging; Mn doping; Prussian blue; photoacoustic imaging; photothermal therapy