title: A Robust Deep Model for Improved Classification of AD/MCI Patients.
abstract: Accurate classification of Alzheimer's disease (AD) and its prodromal stage, mild cognitive impairment (MCI), plays a critical role in possibly preventing progression of memory impairment and improving quality of life for AD patients. Among many research tasks, it is of a particular interest to identify noninvasive imaging biomarkers for AD diagnosis. In this paper, we present a robust deep learning system to identify different progression stages of AD patients based on MRI and PET scans. We utilized the dropout technique to improve classical deep learning by preventing its weight coadaptation, which is a typical cause of overfitting in deep learning. In addition, we incorporated stability selection, an adaptive learning factor, and a multitask learning strategy into the deep learning framework. We applied the proposed method to the ADNI dataset, and conducted experiments for AD and MCI conversion diagnosis. Experimental results showed that the dropout technique is very effective in AD diagnosis, improving the classification accuracies by 5.9% on average as compared to the classical deep learning methods.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Loc
authors.initials: L
authors.lastname: Tran
authors.forename: Kim-Han
authors.initials: KH
authors.lastname: Thung
authors.forename: Shuiwang
authors.initials: S
authors.lastname: Ji
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis*; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D042241:Early Diagnosis; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D000069550:Machine Learning; D008279:Magnetic Resonance Imaging / Q000379:methods; D008962:Models, Theoretical; D049268:Positron-Emission Tomography / Q000379:methods; D025341:Principal Component Analysis; D060388:Support Vector Machine