title: Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease.
abstract: We conducted a case-control study to investigate the association between IL-6 -174 G>C and -572 C>G polymorphisms and the risk of coronary artery disease (CAD). We genotyped IL-6 -174 G>C and -572 C>G in 402 patients with CAD and 402 control individuals. IL-6 -174 G>C (rs1800795) and -572 C>G (rs1800796) alleles were detected by polymerase chain reaction-restriction fragment length polymorphism. Patients with CAD were more likely to have a smoking habit, diabetes, and hypertension, a high level of triglycerides, and low levels of total cholesterol and high- and low-density lipoprotein cholesterol. Multivariate regression analyses showed that subjects carrying the IL-6 -174CC genotype had a small but significant increased risk of CAD (P = 0.004). Those carrying the IL-6 -174 G>C polymorphic variant had a slightly increased risk of CAD in both dominant and recessive models. However, we did not find significant association between the IL-6 -572 C>G polymorphism and risk of CAD. Moreover, a significant interaction was found between the IL-6 -174 G>C polymorphism, gender, and smoking habit. Our study, therefore, demonstrated that the IL-6 -174 G>C polymorphism is correlated with CAD risk, and that this polymorphism shows interactions with both gender and smoking.
authors.affiliation: Department of Cardiovascular Medicine, The First Affiliated Hospital of He'nan University of Science and Technology, Luoyang, Henan, China.
authors.forename: K
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Cardiovascular Medicine, The First Affiliated Hospital of He'nan University of Science and Technology, Luoyang, Henan, China zhanghf588@126.com.
authors.forename: P S
authors.initials: PS
authors.lastname: Dong
authors.affiliation: Department of Cardiovascular Medicine, The First Affiliated Hospital of He'nan University of Science and Technology, Luoyang, Henan, China.
authors.forename: H F
authors.initials: HF
authors.lastname: Zhang
authors.affiliation: Department of Cardiovascular Medicine, The First Affiliated Hospital of He'nan University of Science and Technology, Luoyang, Henan, China.
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Li
authors.affiliation: Department of Cardiovascular Medicine, The First Affiliated Hospital of He'nan University of Science and Technology, Luoyang, Henan, China.
authors.forename: X M
authors.initials: XM
authors.lastname: Yang
authors.affiliation: Emergency Department, 8680 Armed Police Army Hospital, Luoyang, Henan, China.
authors.forename: H
authors.initials: H
authors.lastname: Liu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D015850:Interleukin-6