title: SnapShot: Insulin/IGF1 Signaling.
abstract: The insulin/IGF1signaling pathway (ISP) plays an essential role in long-term health. Some perturbations in this pathway are associated with diseases such as type 2 diabetes; other perturbations extend lifespan in worms, flies, and mice. The ISP regulates many biological processes, including energy storage, apoptosis, transcription, and cellular homeostasis. Such regulation involves precise rewiring of temporal events in protein phosphorylation networks. For an animated version of this Enhanced SnapShot, please visit http://www.cell.com/cell/enhanced/odonoghue.
authors.affiliation: Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia; School of Computer Science and Engineering, UNSW Sydney, NSW 2052, Australia.
authors.forename: David K G
authors.initials: DK
authors.lastname: Ma
authors.affiliation: CSIRO, North Ryde NSW 1670, Australia.
authors.forename: Christian
authors.initials: C
authors.lastname: Stolte
authors.affiliation: Charles Perkins Centre, School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia.
authors.forename: James R
authors.initials: JR
authors.lastname: Krycer
authors.affiliation: Charles Perkins Centre, School of Molecular Bioscience, The University of Sydney, NSW 2006, Australia; Sydney Medical School, The University of Sydney, NSW 2006, Australia.
authors.forename: David E
authors.initials: DE
authors.lastname: James
authors.affiliation: Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia; CSIRO, North Ryde NSW 1670, Australia.
authors.forename: Seán I
authors.initials: SI
authors.lastname: O'Donoghue
mesh_terms: D000818:Animals; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D010766:Phosphorylation; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D007328:Insulin; D011506:Proteins; D007334:Insulin-Like Growth Factor I