title: Downregulation of survivin inhibits proliferation and migration of human gastric carcinoma cells.
abstract: Gastric cancer is the second leading cause of cancer-related death worldwide. Survivin overexpressed in many human cancers as a member of the inhibitor of apoptosis protein family. We found that all samples of normal gastric tissues did not express the protein of survivin, and however, 65% human gastric cancer samples expressed survivin. Positive expression of survivin correlated with differentiation. The proliferation and migration of gastric cancer decreased after downregulation of surviving by RNA interference. Furthermore, downregulation of survivin caused the cell cycle arrest. These suggest that survivin play an important role in gastric cancer and the use of survivin siRNA might become an effective approach to cancer therapy.
authors.affiliation: Department of Pathology, The Affiliated Hospital, Xi'an Medical University Xi'an, China.
authors.forename: Yandong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital, Xi'an Medical University Xi'an, China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Pathology, The Affiliated Hospital, Xi'an Medical University Xi'an, China.
authors.forename: Jianyun
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Gastroenterology, The Affiliated Hospital, Xi'an Medical University Xi'an, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Niu
authors.affiliation: Department of Pathology, The Affiliated Hospital, Xi'an Medical University Xi'an, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Pathology, The Affiliated Hospital, Xi'an Medical University Xi'an, China.
authors.forename: Meini
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Affiliated Hospital, Xi'an Medical University Xi'an, China.
authors.forename: Hangrong
authors.initials: H
authors.lastname: Fang
authors.affiliation: Department of Pathology, The Affiliated Hospital, Xi'an Medical University Xi'an, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Hou
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D002465:Cell Movement; D049109:Cell Proliferation; D015536:Down-Regulation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology*; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin
keywords: Survivin; cell cycle; gastric cancer; migration; proliferation