title: High prevalence of elevated haemoglobin A1C among adolescent blood donors: Results from a voluntary screening programme including 31,546 adolescents.
abstract: More than 1 in 10 US adolescents have prediabetes or diabetes, and elevated glycosylated haemoglobin (HbA1C) in youth is associated with increased risk of death before the age of 55 years. We conducted a prospective, cross-sectional study of 31,546 consecutive volunteer blood donors, 16-19 years of age, who donated blood during school blood drives between 1 September 2011 and 21 December 2012 in Texas. In the overall cohort, the prevalence of elevated HbA1C was 11.5%, including 11.0% in the prediabetes range (HbA1C 5.7%-6.4%) and 0.5% in the diabetes range (HbA1C ⩾ 6.5%). The prevalence of elevated HbA1C was higher in boys compared with girls (15.7% vs. 7.9%, p < 0.001) and was especially high in racial/ethnic minorities (Blacks 32.7%, Asians 19.7%, Hispanics 13.1%) compared with Whites (8.0%, p < 0.001). There was a significant increase in total cholesterol and blood pressure across categories of increasing HbA1C in the overall cohort and stratified by sex and race/ethnicity. Blood donation programmes can serve as unique portals for health screening with potential for intervention in adolescents.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: M Odette
authors.initials: MO
authors.lastname: Gore
authors.affiliation: Carter BloodCare, Bedford, TX, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Eason
authors.affiliation: Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Colby R
authors.initials: CR
authors.lastname: Ayers
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Aslan T
authors.initials: AT
authors.lastname: Turer
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Khera
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: de Lemos
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA Darren.McGuire@UTSouthwestern.edu.
authors.forename: Darren K
authors.initials: DK
authors.lastname: McGuire
authors.affiliation: Carter BloodCare, Bedford, TX, USA Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
authors.forename: Merlyn
authors.initials: M
authors.lastname: Sayers
mesh_terms: D000293:Adolescent; D001741:Black or African American / Q000706:statistics & numerical data; D001213:Asian / Q000706:statistics & numerical data; D001782:Blood Donors; D001794:Blood Pressure; D002784:Cholesterol / Q000378:metabolism; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000208:ethnology / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000208:ethnology / Q000378:metabolism; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D011236:Prediabetic State / Q000453:epidemiology* / Q000208:ethnology / Q000378:metabolism; D011446:Prospective Studies; D012424:Rural Population; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology; D014505:Urban Population; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D002784:Cholesterol; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Glycosylated haemoglobin; diabetes; prediabetes; prevention