title: Values for serum procalcitonin, C-reactive protein, and soluble triggering receptor expressed on myeloid cells-1 in predicting survival of patients with early-onset stroke-associated pneumonia.
abstract: We examined the value of serum procalcitonin (PCT), C-reactive protein (CRP), soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) for predicting the survival of patients with early-onset stroke associated pneumonia (EOP). A total of 207 stroke patients were enrolled, and 91 developed EOP. Upon admission, serum PCT, CRP, sTREM-1 levels, clinical pulmonary infection score, and Acute Physiology and Chronic Health Evaluation II score were all significantly higher in patients with EOP than in those without EOP (P < 0.05). Of the 91 patients who developed EOP, 39 (42.9%) died (non-survivors) within 28 days. The Acute Physiology and Chronic Health Evaluation II score on admission was significantly higher in non-survivors than in survivors (P < 0.05). Serum PCT and sTREM-1 levels were slightly elevated on days 1, 3, and 5 in non-survivors and gradually decreased in survivors. Serum PCT, sTREM-1, and CRP levels were all significantly higher in non-survivors than in survivors on days 1, 3, and 5 (P < 0.05). The sensitivity and specificity of PCT for predicting the outcome of EOP were 84.6 and 71.2%, the sensitivity and specificity of sTREM-1 were 71.8 and 92.3%, and the sensitivity and specificity of sTREM-1 combined with PCT were 74.4 and 96.2%. Serum PCT combined with sTREM-1 accurately predicted the outcome of EOP patients, and dynamic monitoring of serum PCT and sTREM-1 levels is necessary.
authors.affiliation: Department of Geriatrics, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China xiejuansci@163.com.
authors.forename: J
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Emergency Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: Department of Emergency Medicine, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
authors.forename: W Y
authors.initials: WY
authors.lastname: Zhu
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D022423:Myeloid Cells / Q000378:metabolism*; D011014:Pneumonia / Q000097:blood / Q000150:complications*; D011498:Protein Precursors / Q000097:blood*; D011971:Receptors, Immunologic / Q000378:metabolism*; D020521:Stroke / Q000097:blood / Q000150:complications*; D015996:Survival Rate; D055815:Young Adult
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D011971:Receptors, Immunologic; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide