title: [Analysis of some species of magnolia introduced to west georgia, on content of aporphine alkaloids and their biological activity].
abstract: The goal of research was study of vegetative organs of Magnolia species introduced to west Georgia on qualitative and quantitative content of aporphine alkaloids and evaluate cytotoxic activity of total alkaloids from M. officinalis and M. glauca against A-549, DLD-1 and WS-1. Qualitative and quantitative content of aporphine alkaloids in different vegetative organs were determined by chromatographic methods. Based on the researches alkaloids - liriodenine and lanuginozine are characteristic for leaves, for bark of branches - liriodenine, d-caaverine; for bark of trunk - a liriodenine, a caaverine and a magnoflorine. Liriodenine may be considered as is chemotaxonomic sign of genus Magnolia, as it was found in all analyzed vegetative organs. In vitro cytotoxic activity of total alkaloids of M. officinalis and M. glauca has been investigated against DLD-1, WS-1 and A-549. Total alkaloids of M. glauca expressed significant cytotoxic activity against DLD-1 and WS-1, and medium cytotoxicity against A-549; M. officinalis exerted middle activity against A-549, DLD-1, WS-1.
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: N
authors.initials: N
authors.lastname: Vachnadze
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: A
authors.initials: A
authors.lastname: Bakuridze
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: K
authors.initials: K
authors.lastname: Bakuridze
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: A
authors.initials: A
authors.lastname: Bozhadze
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: D
authors.initials: D
authors.lastname: Berashvili
authors.affiliation: Tbilisi State Medical University, Georgia.
authors.forename: V
authors.initials: V
authors.lastname: Vachnadze
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage* / Q000737:chemistry; D001060:Aporphines / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005846:Georgia (Republic); D006801:Humans; D031566:Magnolia / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000470:Alkaloids; D001060:Aporphines; D010936:Plant Extracts; C081279:aporphine