title: Renal biopsy in a patient with haemophilia A and cryoglobulinaemic membranoproliferative glomerulonephritis associated with hepatitis C virus infection.
abstract: A renal biopsy was performed in a 47-year-old man with haemophilia A. Thirty minutes after administration of an intravenous bolus of 4000 units of recombinant factor VIII, which increased the activity to 74-91%, a needle renal biopsy was successfully performed, followed by administration of 3000 units of factor VIII in the evening, and then the subsequent morning and evening. The patient was diagnosed with hepatitis C virus-associated membranoproliferative glomerulonephritis. Treatment with interferon, ribavirin, prednisolone and cyclosporine A improved the nephrotic syndrome. This is the first report of a successful renal biopsy in a patient with haemophilia A after factor VIII injection.
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Ikue
authors.initials: I
authors.lastname: Kobayashi
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Ishimura
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Kaname
authors.initials: K
authors.lastname: Hirowatari
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Tsuchida
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Nishihira
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Shima
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Shidara
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Mori
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inaba
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Wakasa
authors.affiliation: Departments of Nephrology, Pathology, Endocrinology, Metabolism and Molecular Medicine , Osaka City University Graduate School of Medicine , Osaka , Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nishizawa
keywords: haemophilia A; hepatitis C virus; membranoproliferative glomerulonephritis; renal biopsy