title: Personalization of loco-regional care for primary breast cancer patients (part 1).
abstract: ABSTRACT  Kyoto Breast Cancer Consensus Conference, Kyoto, Japan, 18-20 February 2014 The loco-regional management of breast cancer is increasingly complex with application of primary systemic therapies, oncoplastic techniques and genetic testing for breast cancer susceptibility. Personalization of loco-regional treatment is integral to optimization of breast cancer care. Clinical and pathological tumor stage, biological features and host factors influence loco-regional treatment strategies and extent of surgical procedures. Key issues including axillary staging, axillary treatment, radiation therapy, primary systemic therapy (PST), preoperative hormonal therapy and genetic predisposition were identified and discussed at the Kyoto Breast Cancer Consensus Conference (KBCCC2014). In the first of a two part conference scene, consensus recommendations for axillary management are presented and focus on the following topics: indications for completion axillary lymph node dissection in primary surgical patients with ≤2 macrometastases or any sentinel nodal deposits after PST; the timing of sentinel lymph node biopsy in the context of PST; use of axillary irradiation as a component of primary treatment plans and the role of intraoperative node assessment in the post-Z0011 era.
authors.affiliation: Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Toi
authors.forename: Eric P
authors.initials: EP
authors.lastname: Winer
authors.forename: John R
authors.initials: JR
authors.lastname: Benson
authors.forename: Takashi
authors.initials: T
authors.lastname: Inamoto
authors.forename: John F
authors.initials: JF
authors.lastname: Forbes
authors.forename: Gunter
authors.initials: G
authors.lastname: von Minckwitz
authors.forename: John F R
authors.initials: JF
authors.lastname: Robertson
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Grobmyer
authors.forename: Ismail
authors.initials: I
authors.lastname: Jatoi
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
authors.forename: Ian
authors.initials: I
authors.lastname: Kunkler
authors.forename: Alice Y
authors.initials: AY
authors.lastname: Ho
authors.forename: Chikako
authors.initials: C
authors.lastname: Yamauchi
authors.forename: Louis W C
authors.initials: LW
authors.lastname: Chow
authors.forename: Chiun-Sheng
authors.initials: CS
authors.lastname: Huang
authors.forename: Wonshik
authors.initials: W
authors.lastname: Han
authors.forename: Shinzaburo
authors.initials: S
authors.lastname: Noguchi
authors.forename: Mark D
authors.initials: MD
authors.lastname: Pegram
authors.forename: Hideko
authors.initials: H
authors.lastname: Yamauchi
authors.forename: Eun-Sook
authors.initials: ES
authors.lastname: Lee
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Larionov
authors.forename: Jose L B
authors.initials: JL
authors.lastname: Bevilacqua
authors.forename: Michio
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Sugie
authors.forename: Akira
authors.initials: A
authors.lastname: Yamauchi
authors.forename: Ian E
authors.initials: IE
authors.lastname: Krop
authors.forename: Dong Young
authors.initials: DY
authors.lastname: Noh
authors.forename: V Suzanne
authors.initials: VS
authors.lastname: Klimberg
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D019468:Disease Management; D005260:Female; D006801:Humans; D057285:Precision Medicine
keywords: axillary conserving therapy; breast cancer; loco-regional care; preoperative systemic therapy; sentinel lymph node biopsy