title: A facile synthesis of versatile Cu2-xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imaging.
abstract: A novel type of intelligent nanoprobe by using single component of Cu2-xS for multimodal imaging has been facilely and rapidly synthesized in scale via thermal decomposition followed by biomimetic phospholipid modification, which endows them with uniform and small nanoparticle size (ca.15 nm), well phosphate buffer saline (PBS) dispersity, high stability, and excellent biocompatibility. The as-synthesized Cu2-xS nanoprobes (Cu2-xS NPs) are capable of providing contrast enhancement for T1-weighted magnetic resonance imaging (MRI), as demonstrated by the both in vitro and in vivo imaging investigations for the first time. In addition, due to their strong near infrared (NIR) optical absorption, they can also serve as a candidate contrast agent for enhanced infrared thermal/photoacoustic imaging, to meet the shortfalls of MRI. Hence, complementary and potentially more comprehensive information can be acquired for the early detection and accurate diagnosis of cancer. Furthermore, negligible systematic side effects to the blood and tissue were observed in a relatively long period of 3 months. The distinctive multimodal imaging capability with excellent hemo/histocompatibility of the Cu2-xS NPs could open up a new molecular imaging possibility for detecting and diagnosing cancer or other diseases in the future.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Mou
authors.affiliation: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China.
authors.forename: Chengbo
authors.initials: C
authors.lastname: Liu
authors.affiliation: Tenth People's Hospital of Tongji University, Shanghai 200072, PR China.
authors.forename: Pei
authors.initials: P
authors.lastname: Li
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Tenth People's Hospital of Tongji University, Shanghai 200072, PR China.
authors.forename: Huixiong
authors.initials: H
authors.lastname: Xu
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Chenyang
authors.initials: C
authors.lastname: Wei
authors.affiliation: Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China. Electronic address: liang.song@siat.ac.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Song
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: hrchen@mail.sic.ac.cn.
authors.forename: Hangrong
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000032:analysis / Q000138:chemical synthesis; D003300:Copper / Q000032:analysis; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D064847:Multimodal Imaging / Q000379:methods*; D053758:Nanoparticles / Q000032:analysis / Q000648:ultrastructure; D009369:Neoplasms / Q000175:diagnosis*; D061848:Optical Imaging / Q000379:methods; D061088:Photoacoustic Techniques / Q000379:methods*; D013455:Sulfur / Q000032:analysis; D013696:Temperature
chemical_list: D003287:Contrast Media; D013455:Sulfur; D003300:Copper
keywords: Contrast agent; Cu(2−x)S nanoprobe; Infrared thermal imaging; Magnetic resonance imaging; Photoacoustic imaging