title: A proteomic approach to obesity and type 2 diabetes.
abstract: The incidence of obesity and type diabetes 2 has increased dramatically resulting in an increased interest in its biomedical relevance. However, the mechanisms that trigger the development of diabetes type 2 in obese patients remain largely unknown. Scientific, clinical and pharmaceutical communities are dedicating vast resources to unravel this issue by applying different omics tools. During the last decade, the advances in proteomic approaches and the Human Proteome Organization have opened and are opening a new door that may be helpful in the identification of patients at risk and to improve current therapies. Here, we briefly review some of the advances in our understanding of type 2 diabetes that have occurred through the application of proteomics. We also review, in detail, the current improvements in proteomic methodologies and new strategies that could be employed to further advance our understanding of this pathology. By applying these new proteomic advances, novel therapeutic and/or diagnostic protein targets will be discovered in the obesity/Type 2 diabetes area.
authors.affiliation: Departments of Endocrinology and Pediatrics, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain.|Oncohematology and Pediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: López-Villar
authors.affiliation: Departments of Endocrinology and Pediatrics, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain.|Instituto de Investigación La Princesa, Madrid, Spain.|Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Gabriel Á
authors.initials: GÁ
authors.lastname: Martos-Moreno
authors.affiliation: Departments of Endocrinology and Pediatrics, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain.|Instituto de Investigación La Princesa, Madrid, Spain.|Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Chowen
authors.affiliation: Edison Biotechnology Institute, Ohio University, Konneker Research Laboratories, Athens, OH, USA.|Department of Pediatrics, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Okada
authors.affiliation: Edison Biotechnology Institute, Ohio University, Konneker Research Laboratories, Athens, OH, USA.|Molecular and Cellular Biology Program, Ohio University, Athens, OH, USA.|Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Kopchick
authors.affiliation: Departments of Endocrinology and Pediatrics, Hospital Infantil Universitario Niño Jesús, Universidad Autónoma de Madrid, Madrid, Spain.|Instituto de Investigación La Princesa, Madrid, Spain.|Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Argente
mesh_terms: D001800:Blood Specimen Collection; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D006801:Humans; D009765:Obesity / Q000378:metabolism*; D010766:Phosphorylation; D020543:Proteome / Q000378:metabolism; D040901:Proteomics / Q000379:methods*
chemical_list: D020543:Proteome
keywords: biomarkers; diabetes mellitus type 2; obesity; proteomics