title: Screening for cancer: lessons learned from the prostate, lung, colorectal, and ovarian cancer screening trial.
abstract: While the PLCO Cancer Screening trial demonstrated no observed mortality benefit associated with screening for prostate cancer with prostate-specific antigen and rectal exam, the knowledge gained about prostate cancer and screening and resources developed in completing the trial make the trial a success.
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: grubbr@wustl.edu.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Grubb
authors.affiliation: Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Pinsky
authors.affiliation: Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Prorok
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Gerald L
authors.initials: GL
authors.lastname: Andriole
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000401:mortality; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000401:mortality; D018579:Patient Selection; D011237:Predictive Value of Tests; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000401:mortality; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013997:Time Factors