title: Lymphoproliferative Disorders in Patients with Chronic Myeloid Leukemia: A Single-Center Case Series.
abstract: Lymphoproliferative disorders presenting simultaneously with or subsequent to the occurrence of chronic myeloid leukemia (CML) have rarely been reported. Herein, we report 8 cases of a variety of lymphoproliferative conditions associated with CML at different times during the course of the disease. All 8 patients were treated with tyrosine kinase inhibitors at some point during the course of their illness. The literature regarding the uncommon association of these apparently unrelated disorders is reviewed as well as the possible underlying mechanisms that could be associated with this phenomenon.
authors.affiliation: Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ont., Canada.
authors.forename: Nawal F
authors.initials: NF
authors.lastname: Alshehry
authors.forename: Mohammed
authors.initials: M
authors.lastname: Al-Huneini
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Lipton
authors.forename: Fotios V
authors.initials: FV
authors.lastname: Michelis
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D008232:Lymphoproliferative Disorders / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D011505:Protein-Tyrosine Kinases