title: Migratory polyarthritis as an adverse effect of thiamazole use in a 13-year-old girl with Graves' disease.
abstract: Graves' disease is the most prevalent cause of hyperthyroidism in children. The treatment commonly involves antithyroid therapy using a thionamide. We present a case of a 13-year-old girl with the antithyroid arthritis syndrome, presenting as a migratory polyarthritis, after the initiation of thionamide treatment for Graves' disease. Antithyroid arthritis syndrome warranted immediate cessation of thionamide. Improvement of the arthritis was seen in subsequent days. As there are no other reversible treatment modalities for Graves' disease in children, definitive treatment with radioactive iodine was needed to control the hyperthyroidism in this child. Antithyroid arthritis syndrome presenting as a migratory polyarthritis is a severe adverse effect of a common pediatric disease and should therefore be recognized by pediatricians.
authors.forename: Jo-Anne
authors.initials: JA
authors.lastname: Janson
authors.forename: Paul
authors.initials: P
authors.lastname: de Laat
authors.forename: Jos M T
authors.initials: JM
authors.lastname: Draaisma
mesh_terms: D000293:Adolescent; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001168:Arthritis / Q000139:chemically induced*; D005260:Female; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D008713:Methimazole / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D013956:Antithyroid Agents; D008713:Methimazole