title: Age-related responses in circulating markers of redox status in healthy adolescents and adults during the course of a training macrocycle.
abstract: Redox status changes during an annual training cycle in young and adult track and field athletes and possible differences between the two age groups were assessed. Forty-six individuals (24 children and 22 adults) were assigned to four groups: trained adolescents, (TAD, N = 13), untrained adolescents (UAD, N = 11), trained adults (TA, N = 12), and untrained adults (UA, N = 10). Aerobic capacity and redox status related variables [total antioxidant capacity (TAC), glutathione (GSH), catalase activity, TBARS, protein carbonyls (PC), uric acid, and bilirubin] were assessed at rest and in response to a time-trial bout before training, at mid- and posttraining. TAC, catalase activity, TBARS, PC, uric acid, and bilirubin increased and GSH declined in all groups in response to acute exercise independent of training status and age. Training improved aerobic capacity, TAC, and GSH at rest and in response to exercise. Age affected basal and exercise-induced responses since adults demonstrated a greater TAC and GSH levels at rest and a greater rise of TBARS, protein carbonyls, and TAC and decline of GSH in response to exercise. Catalase activity, uric acid, and bilirubin responses were comparable among groups. These results suggest that acute exercise, age, and training modulate the antioxidant reserves of the body.
authors.affiliation: Department of Physical Education & Sport Science, University of Thessaly, Karies, 42100 Trikala, Greece.
authors.forename: Athanasios
authors.initials: A
authors.lastname: Zalavras
authors.affiliation: Department of Physical Education & Sport Science, University of Thrace, 69100 Komotini, Greece ; Department of Kinesiology, Institute for Research & Technology, Thessaly, 42100 Trikala, Greece.
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Fatouros
authors.affiliation: Department of Physical Education & Sport Science, University of Thessaly, Karies, 42100 Trikala, Greece ; Department of Kinesiology, Institute for Research & Technology, Thessaly, 42100 Trikala, Greece.
authors.forename: Chariklia K
authors.initials: CK
authors.lastname: Deli
authors.affiliation: Department of Physical Education & Sport Science, University of Thrace, 69100 Komotini, Greece.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Draganidis
authors.affiliation: Department of Physical Education & Sport Science, University of Thessaly, Karies, 42100 Trikala, Greece.
authors.forename: Anastasios A
authors.initials: AA
authors.lastname: Theodorou
authors.affiliation: Department of Physical Education & Sport Science, University of Thessaly, Karies, 42100 Trikala, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Soulas
authors.affiliation: Department of Physical Education & Sport Science, University of Thessaly, Karies, 42100 Trikala, Greece.
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Koutsioras
authors.affiliation: Department of Physical Education & Sport Science, University of Thessaly, Karies, 42100 Trikala, Greece ; Department of Physical Education & Sport Science, University of Thrace, 69100 Komotini, Greece ; School of Sport, Performing Arts & Leisure, Wolverhampton University, Gorway Road, Walsall, West Midlands WS1 3BD, UK.
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Koutedakis
authors.affiliation: Department of Physical Education & Sport Science, University of Thessaly, Karies, 42100 Trikala, Greece ; Department of Kinesiology, Institute for Research & Technology, Thessaly, 42100 Trikala, Greece.
authors.forename: Athanasios Z
authors.initials: AZ
authors.lastname: Jamurtas
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000975:Antioxidants / Q000378:metabolism; D001663:Bilirubin / Q000032:analysis; D015415:Biomarkers / Q000097:blood / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D015444:Exercise; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D010101:Oxygen Consumption; D050050:Protein Carbonylation; D014527:Uric Acid / Q000032:analysis
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014527:Uric Acid; D002374:Catalase; D005978:Glutathione; D001663:Bilirubin