title: Narrow-band imaging versus white light for the detection of proximal colon serrated lesions: a randomized, controlled trial.
abstract: BACKGROUND
  The value of narrow-band imaging (NBI) for detecting serrated lesions is unknown.
  
  
  OBJECTIVE
  To assess NBI for the detection of proximal colon serrated lesions.
  
  
  METHODS
  Randomized, controlled trial.
  
  
  METHODS
  Two academic hospital outpatient units.
  
  
  METHODS
  Eight hundred outpatients 50 years of age and older with intact colons undergoing routine screening, surveillance, or diagnostic examinations.
  
  
  METHODS
  Randomization to colon inspection in NBI versus white-light colonoscopy.
  
  
  METHODS
  The number of serrated lesions (sessile serrated polyps plus hyperplastic polyps) proximal to the sigmoid colon.
  
  
  RESULTS
  The mean inspection times for the whole colon and proximal colon were the same for the NBI and white-light groups. There were 204 proximal colon lesions in the NBI group and 158 in the white light group (P = .085). Detection of conventional adenomas was comparable in the 2 groups.
  
  
  CONCLUSIONS
  Lack of blinding, endoscopic estimation of polyp location.
  
  
  CONCLUSIONS
  NBI may increase the detection of proximal colon serrated lesions, but the result in this trial did not reach significance. Additional study of this issue is warranted. (
  
  
  BACKGROUND
  NCT01572428.).
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Douglas K
authors.initials: DK
authors.lastname: Rex
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Clodfelter
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Farrah
authors.initials: F
authors.lastname: Rahmani
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Hala
authors.initials: H
authors.lastname: Fatima
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Toyia N
authors.initials: TN
authors.lastname: James-Stevenson
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Tang
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Hak Nam
authors.initials: HN
authors.lastname: Kim
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Lee
authors.initials: L
authors.lastname: McHenry
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Kahi
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Rogers
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Helper
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Sashidhar V
authors.initials: SV
authors.lastname: Sagi
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Kessler
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Wo
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Monika
authors.initials: M
authors.lastname: Fischer
authors.affiliation: Division of Gastroenterology/Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Paul Y
authors.initials: PY
authors.lastname: Kwo
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology*; D003106:Colon / Q000473:pathology*; D044682:Colon, Ascending / Q000473:pathology; D044683:Colon, Descending / Q000473:pathology; D044684:Colon, Transverse / Q000473:pathology; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000473:pathology*; D003111:Colonic Polyps / Q000175:diagnosis / Q000473:pathology*; D003113:Colonoscopy / Q000379:methods*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging / Q000379:methods*