title: Leiomyosarcoma of Larynx as a Metachronous Tumor of Squamous Cell Carcinoma: An Unusual Case.
abstract: Leiomyosarcomas (LMSs) are malignant tumors of smooth muscles accounting for 5-6% of all soft tissue sarcomas. They are mostly seen in the gastrointestinal tractus, the uterus, and the retroperitoneum. Soft tissue sarcomas comprise <1% of all laryngeal malignancies, most of which are chondrosarcomas. Laryngeal LMSs are rarely seen malignancies, which are published as case reports. We presented a case of laryngeal LMS, which was seen 4 years later in a laryngeal squamous cell carcinoma patient who underwent laryngeal laser microsurgery. We discussed the diagnosis and treatment algorithm in the light of the present literature.
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, University of Mersin, Mersin, Turkey. Electronic address: dronurismi@gmail.com.
authors.forename: Onur
authors.initials: O
authors.lastname: Ismi
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors.forename: Rabia Bozdogan
authors.initials: RB
authors.lastname: Arpaci
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors.forename: Tugce
authors.initials: T
authors.lastname: Puturgeli
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozcan
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, University of Mersin, Mersin, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Gorur
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D006258:Head and Neck Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods; D007890:Leiomyosarcoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery; D016609:Neoplasms, Second Primary; D011237:Predictive Value of Tests; D018714:Radiotherapy, Adjuvant; D000077195:Squamous Cell Carcinoma of Head and Neck; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Larynx; Leiomyosarcoma; Metachronous; Squamous cell carcinoma