title: Healing after death: antitumor immunity induced by oncolytic adenoviral therapy.
abstract: We recently evaluated the capacity of Delta-24-RGD oncolytic adenovirus to trigger an antitumor immune response in a syngeneic mouse glioma model. This virotherapy elicited immunity against both tumor-associated antigens and viral antigens. An immunogenic cell death accompanied by pathogen- or damage- associated patterns (PAMPs and DAMPs) induced by the virus may be responsible for the adenoviral-mediated antitumor effect.
authors.affiliation: Brain Tumor Center; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Brain Tumor Center; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Fueyo
keywords: antitumor immunity; danger (or damage)-associated molecular patterns (DAMPs); immunogenic cell death; oncolytic adenovirus; pathogen-associated patterns (PAMPs)