title: Interaction of silver nanoparticles with tethered bilayer lipid membranes.
abstract: Silver nanoparticles are well-known for their antibacterial properties. However, the detailed mechanism describing the interaction between the nanoparticles and a cell membrane is not fully understood, which can impede the use of the particles in biomedical applications. Here, a tethered bilayer lipid membrane has been used as a model system to mimic a natural membrane and to study the effect of exposure to small silver nanoparticles with diameters of about 2 nm. The solid supported membrane architecture allowed for the application of surface analytical techniques such as electrochemical impedance spectroscopy and atomic force microscopy. Exposure of the membrane to solutions of the silver nanoparticles led to a small but completely reversible perturbation of the lipid bilayer.
authors.affiliation: Flinders Centre for NanoScale Science and Technology and School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA, Australia 5042.
authors.forename: Renee V
authors.initials: RV
authors.lastname: Goreham
authors.affiliation: Flinders Centre for NanoScale Science and Technology and School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA, Australia 5042.
authors.forename: Vanessa C
authors.initials: VC
authors.lastname: Thompson
authors.affiliation: Flinders Centre for NanoScale Science and Technology and School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA, Australia 5042.
authors.forename: Yuya
authors.initials: Y
authors.lastname: Samura
authors.affiliation: Flinders Centre for NanoScale Science and Technology and School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA, Australia 5042.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Gibson
authors.affiliation: Flinders Centre for NanoScale Science and Technology and School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA, Australia 5042.
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Shapter
authors.affiliation: Flinders Centre for NanoScale Science and Technology and School of Chemical and Physical Sciences, Flinders University, Bedford Park, SA, Australia 5042.
authors.forename: Ingo
authors.initials: I
authors.lastname: Köper
mesh_terms: D058266:Dielectric Spectroscopy; D008051:Lipid Bilayers / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D012834:Silver / Q000737:chemistry*
chemical_list: D008051:Lipid Bilayers; D012834:Silver