title: Coaxial nanofibers of chitosan-alginate-PEO polycomplex obtained by electrospinning.
abstract: Electrospinning of mucoadhesive membranes is a new and promising field of investigation in the pharmaceutical and biomedical area. The present study explored the electrospinning of two mucoadhesive polymers, chitosan and alginate, to form a core-shell type nanofibers for future applications as controlled drug delivery. Due to the charged functional groups present in these natural polysaccharides, they can complex to yield various nanodevices to be used in controlled release of several active ingredients. In this work, the core-shell type coaxial nanofibers formation was evidenced by the aid of transmission electron microscopy (TEM). Other characterization techniques as scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Infrared spectroscopy (FTIR) and X-ray diffraction (XRD), strongly suggest the formation of different molecular structures of the membranes obtained by the complexation of chitosan and alginate. Swelling rate and weight loss tests followed by SEM analyses confirmed that the nanofiber structure of these membranes were kept even after incubating them for 24h in water. The results of this work confirmed that core-shell nanofibers made of chitosan and alginate polycomplex is possible to be obtained with success.
authors.affiliation: Department of Materials Engineering and Bioprocess, Chemical Engineering School, State University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: silnista@yahoo.com.br.
authors.forename: Silvia Vaz Guerra
authors.initials: SV
authors.lastname: Nista
authors.affiliation: Electron Microscopy Laboratory, Brazilian Nanotechnology National Laboratory, Campinas, SP, Brazil.
authors.forename: Jefferson
authors.initials: J
authors.lastname: Bettini
authors.affiliation: Department of Materials Engineering and Bioprocess, Chemical Engineering School, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
authors.forename: Lucia Helena Innocentini
authors.initials: LH
authors.lastname: Mei
mesh_terms: D000464:Alginates / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D057139:Nanofibers / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D058105:Polymerization
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D011092:Polyethylene Glycols; D020723:Glucuronic Acid; D048271:Chitosan
keywords: Alginate; Biomaterials; Chitosan; Chitosan (PubChem SID 3997); Electrospinning; Nanofiber; Polyelectrolyte; Sodium alginate (PubChem SID 496141)