title: An Algorithm Using Twelve Properties of Antibiotics to Find the Recommended Antibiotics, as in CPGs.
abstract: BACKGROUND
  Clinical Decision Support Systems (CDSS) incorporating justifications, updating and adjustable recommendations can considerably improve the quality of healthcare. We propose a new approach to the design of CDSS for empiric antibiotic prescription, based on implementation of the deeper medical reasoning used by experts in the development of clinical practice guidelines (CPGs), to deduce the recommended antibiotics.
  
  
  METHODS
  We investigated two methods ("exclusion" versus "scoring") for reproducing this reasoning based on antibiotic properties.
  
  
  RESULTS
  The "exclusion" method reproduced expert reasoning the more accurately, retrieving the full list of recommended antibiotics for almost all clinical situations.
  
  
  CONCLUSIONS
  This approach has several advantages: (i) it provides convincing explanations for physicians; (ii) updating could easily be incorporated into the CDSS; (iii) it can provide recommendations for clinical situations missing from CPGs.
authors.affiliation: INSERM, U1142, LIMICS, F-75006, Paris, France ; Université Paris 13, Sorbonne Paris Cité, F-93000, Bobigny, France ; Sorbonne Universités, Univ Paris 06, F-75006, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Tsopra
authors.affiliation: INSERM, U1142, LIMICS, F-75006, Paris, France ; Université Paris 13, Sorbonne Paris Cité, F-93000, Bobigny, France ; Sorbonne Universités, Univ Paris 06, F-75006, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Venot
authors.affiliation: INSERM, U1142, LIMICS, F-75006, Paris, France ; Université Paris 13, Sorbonne Paris Cité, F-93000, Bobigny, France ; Sorbonne Universités, Univ Paris 06, F-75006, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Duclos
mesh_terms: D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D020000:Decision Support Systems, Clinical; D004360:Drug Therapy, Computer-Assisted; D019317:Evidence-Based Medicine; D006801:Humans; D017410:Practice Guidelines as Topic
chemical_list: D000900:Anti-Bacterial Agents