title: Death-associated protein kinase: A molecule with functional antagonistic duality and a potential role in inflammatory bowel disease (Review).
abstract: The cytoskeleton-associated serine/threonine kinase death-associated protein kinase (DAPK) has been described as a cancer gene chameleon with functional antagonistic duality in a cell type and context specific manner. The broad range of interaction partners and substrates link DAPK to inflammatory processes especially in the gut. Herein we summarize our knowledge on the role of DAPK in different cell types that play a role under inflammatory conditions in the gut. Besides some promising experimental data suggesting DAPK as an interesting drug target in inflammatory bowel disease there are many open questions regarding direct evidence for a role of DAPK in intestinal inflammation.
authors.affiliation: Experimental Tumorpathology, Institute of Pathology, FAU Erlangen-Nürnberg, 91054 Erlangen, Germany.
authors.forename: Sara
authors.initials: S
authors.lastname: Steinmann
authors.affiliation: Department of Medicine 1, University Hospital Erlangen, FAU Erlangen-Nürnberg, Kussmaul Campus for Medical Research, 91052 Erlangen, Germany.
authors.forename: Kristina
authors.initials: K
authors.lastname: Scheibe
authors.affiliation: Institute of Pathology, FAU Erlangen-Nürnberg, 91054 Erlangen, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Erlenbach-Wuensch
authors.affiliation: Department of Medicine 1, University Hospital Erlangen, FAU Erlangen-Nürnberg, Kussmaul Campus for Medical Research, 91052 Erlangen, Germany.
authors.forename: Clemens
authors.initials: C
authors.lastname: Neufert
authors.affiliation: Experimental Tumorpathology, Institute of Pathology, FAU Erlangen-Nürnberg, 91054 Erlangen, Germany.
authors.forename: Regine
authors.initials: R
authors.lastname: Schneider-Stock
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D016923:Cell Death; D003110:Colonic Neoplasms / Q000378:metabolism; D064550:Death-Associated Protein Kinases / Q000737:chemistry / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; C579096:DAPK1 protein, human; D064550:Death-Associated Protein Kinases