title: Silver(I)- or copper(II)-mediated dearomatization of aromatic ynones: direct access to spirocyclic scaffolds.
abstract: A high-yielding silver(I)- or copper(II)-catalyzed dearomatizing spirocyclization strategy allows the conversion of simple aromatic compounds that contain ynone substituents, including indole, anisole, pyrrole, and benzofuran derivatives, into functionalized spirocyclic scaffolds. A high-yielding asymmetric variant furnishes spirocyclic indolenines in up to 89:11 e.r.
authors.affiliation: University of York, York (UK).
authors.forename: Michael J
authors.initials: MJ
authors.lastname: James
authors.affiliation: University of York, York (UK).
authors.forename: James D
authors.initials: JD
authors.lastname: Cuthbertson
authors.affiliation: University of York, York (UK).
authors.forename: Peter
authors.initials: P
authors.lastname: O'Brien
authors.affiliation: University of York, York (UK). richard.taylor@york.ac.uk.
authors.forename: Richard J K
authors.initials: RJ
authors.lastname: Taylor
authors.affiliation: University of York, York (UK). william.unsworth@york.ac.uk.
authors.forename: William P
authors.initials: WP
authors.lastname: Unsworth
keywords: asymmetric catalysis; dearomatization; indolenines; silver; spirocycles