title: Cross-Reactive Epitopes in Borrelia burgdorferi p66.
abstract: Epitope mapping of the p66 outer membrane protein of Borrelia burgdorferi revealed that the protein contains numerous cross-reactive linear epitopes recognized by serum antibody in the majority of individuals tested, regardless of Lyme disease history, limiting the usefulness of this antigen in Lyme disease serodiagnostic assays.
authors.affiliation: Biopeptides Corp., East Setauket, New York, USA, and Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA paul_arnaboldi@nymc.edu.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Arnaboldi
authors.affiliation: Biopeptides Corp., East Setauket, New York, USA, and Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Dattwyler
mesh_terms: D001426:Bacterial Proteins / Q000276:immunology*; D025065:Borrelia burgdorferi / Q000276:immunology*; D003429:Cross Reactions; D018604:Epitope Mapping; D018985:Epitopes, B-Lymphocyte / Q000276:immunology*; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis; D018272:Porins / Q000276:immunology*; D012698:Serologic Tests / Q000379:methods
chemical_list: D001426:Bacterial Proteins; D018985:Epitopes, B-Lymphocyte; C107893:Oms66 protein, Borrelia; D018272:Porins