title: A giant mass on the left shin: report of a case.
abstract: A woman presented to our department with an asymptomatic progressive peripherally expanding skin lesion on her left shin for 6 years. The doctor in a local clinic considered it was a deep fungal infection, however, treatment with itraconazole systemically was ineffective. A second biopsy showed papillomatous hyperplasia and a central keratin-filled crater with a buttress like extension of surrounding epidermis and a well-demarcated regular base. In the upper dermis, diffused infiltration of mixed inflammatory cells was observed with perivascular infiltrate. Deeper dermis, appendageal structures and subcutaneous tissue were unremarkable. Periodic acid-schiffic staining and diamine silver staining of the specimen were negative. A diagnosis of Keratoacanthoma centrifugum marginatum (KCM) was finally established.
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University Changsha, China.
authors.forename: Lixia
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University Changsha, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Su
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University Changsha, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Xiangya Hospital, Central South University Changsha, China.
authors.forename: Mingliang
authors.initials: M
authors.lastname: Chen
mesh_terms: D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007636:Keratoacanthoma / Q000473:pathology*; D007866:Leg / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*
keywords: Mass; acitretin; cancer; dermatopathology; keratoacanthoma centrifugum marginatum; leg ulcer