title: The Influence of Aconitum carmichaelii Debx. on the Pharmacokinetic Characteristics of Main Components in Rheum palmatum L.
abstract: Rhei Radix et Rhizoma was one of the commonly used traditional Chinese medicines, and the compatibility of Rhei Radix et Rhizoma and Aconiti Lateralis Radix Praeparata was the basic herb pair applied in many Chinese traditional prescription. Rhubarb anthraquinones were the main bioactive materials of Rhei Radix et Rhizoma. To elucidate the compatibility of Rhei Radix et Rhizoma and Aconiti Lateralis Radix Praeparata, the pharmacokinetics of rhubarb anthraquinones as the main marker constituents were investigated. In the present study, pharmacokinetic differences of rhubarb anthraquinones were detected after oral administration of extract of Rheum palmatum L. and compatibility with Aconitum carmichaelii Debx. After oral administration, no difference of peak time can be found for anthraquinones between rhubarb group and compatibility group. But Cmax and area under the curve of aloe-emodin, emodin and chrysophanol in compatibility group were significantly higher than that in rhubarb group. Although the Cmax of rhein in compatibility group was much lower than that in rhubarb group, the area under the curve value was similar in two groups. The clearance and t1/2 of rhubarb anthraquinone were also changed after compatibility. The change of pharmacokinetics characteristics of rhubarb anthraquinone after compatibility may be caused by the drug-drug interaction medicated by chemical reaction and cytochromes P450.
authors.affiliation: Pharmacy College, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
authors.forename: Yun-xia
authors.initials: YX
authors.lastname: Li
authors.affiliation: Pharmacy College, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Gong
authors.affiliation: Pharmacy College, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Pharmacy College, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
authors.forename: Ruo-qi
authors.initials: RQ
authors.lastname: Zhang
authors.affiliation: Pharmacy College, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
authors.forename: An
authors.initials: A
authors.lastname: Yuan
authors.affiliation: Pharmacy College, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
authors.forename: Meng-jie
authors.initials: MJ
authors.lastname: Zhao
authors.affiliation: Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, China.
authors.forename: Dai-wen
authors.initials: DW
authors.lastname: Zeng
authors.affiliation: Pharmacy College, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000284:Administration, Oral; D000818:Animals; D000880:Anthraquinones / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D004642:Emodin; D008297:Male; D010936:Plant Extracts / Q000493:pharmacokinetics; D018517:Plant Roots / Q000737:chemistry; D017207:Rats, Sprague-Dawley; D012250:Rheum / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry
chemical_list: D000880:Anthraquinones; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C518327:aloe emodin; D004642:Emodin; C027113:chrysophanic acid; C020491:rhein
keywords: Aconitum carmichaelii Debx; Rheum palmatum L; comparative pharmacokinetics; compatibility; rhubarb anthraquinones