title: The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation.
abstract: Providing a pre-operative prognosis for dogs presented with absent deep pain perception (DPP) is extremely challenging, as the overall recovery rates widely vary. This study assesses the possible correlation between the severity of spinal cord injury and CSF cytology in 31 paraplegic dogs presented with absent DPP due to acute thoracolumbar intervertebral disc herniation (TL-IVDH). All dogs underwent surgical decompression immediately following diagnosis. CSF TNCC, macrophage percentage and macrophage to monocyte (MΦ:M) ratio were significantly higher in dogs that failed to regain DPP within 10 days post-operatively and in dogs that failed to regain ambulation at the end of the study period (P< 0.05). MΦ:M of 0.73 and higher corresponded to a sensitivity of 54% and specificity of 100% for prediction of a negative long-term outcome. CSF TNCC, macrophage percentage and MΦ:M ratio effectively predicted regaining DPP and the long-term outcome in dogs that lost DPP due to acute TL-IVDH.
authors.affiliation: Department of Neurology and Neurosurgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Chamisha
authors.affiliation: Department of Small Animal Internal Medicine, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Aroch
authors.affiliation: Department of Small Animal Internal Medicine, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Kuzi
authors.affiliation: Department of Neurology and Neurosurgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Srugo
authors.affiliation: Teaching Services Unit, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, Israel.
authors.forename: T
authors.initials: T
authors.lastname: Bdolah-Abram
authors.affiliation: Department of Neurology and Neurosurgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Chai
authors.affiliation: Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Christopher
authors.affiliation: Department of Neurology and Neurosurgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Merbl
authors.affiliation: Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.
authors.forename: K
authors.initials: K
authors.lastname: Rothwell
authors.affiliation: Department of Neurology and Neurosurgery, Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel. Electronic address: merav.shamir@mail.huji.ac.il.
authors.forename: M H
authors.initials: MH
authors.lastname: Shamir
mesh_terms: D000818:Animals; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000166:cytology; D004283:Dog Diseases / Q000134:cerebrospinal fluid* / Q000503:physiopathology / Q000601:surgery; D004285:Dogs; D055959:Intervertebral Disc Degeneration / Q000134:cerebrospinal fluid / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D007405:Intervertebral Disc Displacement / Q000134:cerebrospinal fluid / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D008159:Lumbar Vertebrae / Q000503:physiopathology* / Q000601:surgery; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013119:Spinal Cord Injuries / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D013904:Thoracic Vertebrae / Q000503:physiopathology* / Q000601:surgery
keywords: CSF; Deep pain perception; Dog; Intervertebral disc herniation; Prognosis