title: Targeting hypoxia at the forefront of anticancer immune responses.
abstract: Hypoxia influences immune checkpoint receptors and their respective ligands. In support, we recently demonstrated that hypoxia selectively upregulates programmed cell death ligand 1 (PD-L1) on myeloid-derived suppressor cells (MDSCs) via hypoxia inducible factor 1 α (HIF-1α) binding to a hypoxia-response element (HRE) in the PD-L1 proximal promoter. Furthermore, blockade of PD-L1 under hypoxic conditions enhanced MDSC-mediated T-cell activation by attenuating MDSC secretion of IL-6 and IL-10.
authors.affiliation: Unité INSERM U753; Institut de Cancérologie Gustave Roussy ; Villejuif, France.
authors.forename: Muhammad Zaeem
authors.initials: MZ
authors.lastname: Noman
authors.affiliation: Unité INSERM U753; Institut de Cancérologie Gustave Roussy ; Villejuif, France.
authors.forename: Salem
authors.initials: S
authors.lastname: Chouaib
keywords: HIF-1α; IL-10; MDSC; PD-L1; hypoxia; immune suppression