title: Dark Agouti rat model of chemotherapy-induced mucositis: establishment and current state of the art.
abstract: Mucositis is a major oncological problem. The entire gastrointestinal and genitourinary tract and also other mucosal surfaces can be affected in recipients of radiotherapy, and/or chemotherapy. Major progress has been made in recent years in understanding the mechanisms of oral and small intestinal mucositis, which appears to be more prominent than colonic damage. This progress is largely due to the development of representative laboratory animal models of mucositis. This review focuses on the development and establishment of the Dark Agouti rat mammary adenocarcinoma model by the Mucositis Research Group of the University of Adelaide over the past 20 years to characterize the mechanisms underlying methotrexate-, 5-fluorouracil-, and irinotecan-induced mucositis. It also aims to summarize the results from studies using different animal model systems to identify new molecular and cellular markers of mucositis.
authors.affiliation: Mucositis Research Group, Centre for Personalised Cancer Medicine (CPCM), Centre for Clinical Research Excellence (CCRE) in Oral Health, Faculty of Health Sciences, University of Adelaide, Adelaide, 5005 South Australia, Australia Laboratory of Microbial Ecology and Technology, University of Ghent, 9000 Ghent, Belgium.
authors.forename: Barbara
authors.initials: B
authors.lastname: Vanhoecke
authors.affiliation: Mucositis Research Group, Centre for Personalised Cancer Medicine (CPCM), Centre for Clinical Research Excellence (CCRE) in Oral Health, Faculty of Health Sciences, University of Adelaide, Adelaide, 5005 South Australia, Australia.
authors.forename: Emma
authors.initials: E
authors.lastname: Bateman
authors.affiliation: Mucositis Research Group, Centre for Personalised Cancer Medicine (CPCM), Centre for Clinical Research Excellence (CCRE) in Oral Health, Faculty of Health Sciences, University of Adelaide, Adelaide, 5005 South Australia, Australia Sansom Institute for Health Research, University of South Australia, Adelaide, 5001 South Australia, Australia.
authors.forename: Bronwen
authors.initials: B
authors.lastname: Mayo
authors.affiliation: Laboratory of Microbial Ecology and Technology, University of Ghent, 9000 Ghent, Belgium.
authors.forename: Eline
authors.initials: E
authors.lastname: Vanlancker
authors.affiliation: Sansom Institute for Health Research, University of South Australia, Adelaide, 5001 South Australia, Australia andrea.stringer@unisa.edu.au.
authors.forename: Andrea
authors.initials: A
authors.lastname: Stringer
authors.affiliation: Sansom Institute for Health Research, University of South Australia, Adelaide, 5001 South Australia, Australia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Thorpe
authors.affiliation: Mucositis Research Group, Centre for Personalised Cancer Medicine (CPCM), Centre for Clinical Research Excellence (CCRE) in Oral Health, Faculty of Health Sciences, University of Adelaide, Adelaide, 5005 South Australia, Australia Director, SA Cancer Service, Royal Adelaide Hospital, Adelaide, 5005 South Australia, Australia.
authors.forename: Dorothy
authors.initials: D
authors.lastname: Keefe
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000494:pharmacology; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000494:pharmacology; D006801:Humans; D000077146:Irinotecan; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008727:Methotrexate / Q000009:adverse effects / Q000494:pharmacology; D051379:Mice; D052016:Mucositis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D051381:Rats
chemical_list: D000077146:Irinotecan; D005472:Fluorouracil; D002166:Camptothecin; D008727:Methotrexate
keywords: 5-fluorouracil; Rat; chemotherapy; irinotecan; methotrexate; mucositis