title: Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus.
abstract: The kidneys and the blood system mutually exert influence in maintaining homeostasis in the body. Because the kidneys control erythropoiesis by producing erythropoietin and by supporting hematopoiesis, anemia is associated with kidney diseases. Anemia is the most prevalent genetic disorder, and it is caused by a deficiency of glucose 6-phosphate dehydrogenase (G6PD), for which sulfhydryl oxidation due to an insufficient supply of NADPH is a likely direct cause. Elevated reactive oxygen species (ROS) result in the sulfhydryl oxidation and hence are another potential cause for anemia. ROS are elevated in red blood cells (RBCs) under superoxide dismutase (SOD1) deficiency in C57BL/6 mice. SOD1 deficient mice exhibit characteristics similar to autoimmune hemolytic anemia (AIHA) and systemic lupus erythematosus (SLE) at the gerontic stage. An examination of AIHA-prone New Zealand Black (NZB) mice, which have normal SOD1 and G6PD genes, indicated that ROS levels in RBCs are originally high and further elevated during aging. Transgenic overexpression of human SOD1 in erythroid cells effectively suppresses ROS elevation and ameliorates AIHA symptoms such as elevated anti-RBC antibodies and premature death in NZB mice. These results support the hypothesis that names oxidative stress as a risk factor for AIHA and other autoimmune diseases such as SLE. Herein we discuss the association between oxidative stress and SLE pathogenesis based mainly on the genetic and phenotypic characteristics of NZB and New Zealand white mice and provide insight into the mechanism of SLE pathogenesis.
authors.affiliation: Junichi Fujii, Toshihiro Kurahashi, Tasuku Konno, Takujiro Homma, Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata-city, Yamagata 990-9585, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Fujii
authors.affiliation: Junichi Fujii, Toshihiro Kurahashi, Tasuku Konno, Takujiro Homma, Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata-city, Yamagata 990-9585, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kurahashi
authors.affiliation: Junichi Fujii, Toshihiro Kurahashi, Tasuku Konno, Takujiro Homma, Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata-city, Yamagata 990-9585, Japan.
authors.forename: Tasuku
authors.initials: T
authors.lastname: Konno
authors.affiliation: Junichi Fujii, Toshihiro Kurahashi, Tasuku Konno, Takujiro Homma, Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata-city, Yamagata 990-9585, Japan.
authors.forename: Takujiro
authors.initials: T
authors.lastname: Homma
authors.affiliation: Junichi Fujii, Toshihiro Kurahashi, Tasuku Konno, Takujiro Homma, Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata-city, Yamagata 990-9585, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Iuchi
keywords: Autoimmune hemolytic anemia; New Zealand black mice; New Zealand white mice; Red blood cells; Systemic lupus erythematosus