title: Late Reactivation of Cherubism in a Patient With New-Onset Polycystic Ovary Syndrome.
abstract: OBJECTIVE
  The aim of the present study was to describe a case of cherubism with late progression, after skeletal maturity had been reached, that coincided with a recent diagnosis of polycystic ovary syndrome (PCOS).
  
  
  METHODS
  We reviewed the published data and searched for any reported association between cherubism and PCOS. We also reviewed the cases of late reactivation of cherubism.
  
  
  RESULTS
  This is, to our knowledge, the first case report of cherubism associated with PCOS.
  
  
  CONCLUSIONS
  Cherubism is a rare condition, which, in its normal course, becomes quiescent after puberty. Only a few cases of late growth have been reported. The understanding of the condition has evolved in recent years, with a better appreciation of the underlying genetics and pathogenesis of the disease. However, much remains unknown about this rare entity. We describe a case of cherubism reactivation that coincided with changes related to PCOS. Both PCOS and cherubism are associated with a low-grade inflammatory state.
authors.affiliation: Junior Clinical Fellow, Department of Oral and Maxillofacial Surgery, King's College Hospital, London, UK. Electronic address: Daniel.lenouvel@nhs.net.
authors.forename: Daniel
authors.initials: D
authors.lastname: Lenouvel
authors.affiliation: Specialty Registrar, Department of Oral and Maxillofacial Surgery, King's College Hospital, London, UK.
authors.forename: David
authors.initials: D
authors.lastname: Chapireau
authors.affiliation: Consultant, Department of Oral and Maxillofacial Surgery, King's College Hospital, London, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Bentley
mesh_terms: D000328:Adult; D002636:Cherubism / Q000150:complications* / Q000000981:diagnostic imaging; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011862:Radiography, Panoramic; D012008:Recurrence