title: The development of a nucleus staining fluorescent probe for dynamic mitosis imaging in live cells.
abstract: A low-toxicity nucleus staining fluorescent probe, , was developed for real time mitosis imaging in live cells. was identified by unbiased high-throughput imaging-based screening of a new xanthone library (AX). Unlike the conventional Hoechst dye, the low toxicity of allows long term monitoring of cell division over more than one cell cycle.
authors.affiliation: Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 117543 Singapore. chmcyt@nus.edu.sg.
authors.forename: Krishna Kanta
authors.initials: KK
authors.lastname: Ghosh
authors.forename: Yun-Mi
authors.initials: YM
authors.lastname: Jeong
authors.forename: Nam-Young
authors.initials: NY
authors.lastname: Kang
authors.forename: JungYeol
authors.initials: J
authors.lastname: Lee
authors.forename: Wan
authors.initials: W
authors.lastname: Si Yan Diana
authors.forename: Jun-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Jaeduk
authors.initials: J
authors.lastname: Yoo
authors.forename: Dohee
authors.initials: D
authors.lastname: Kim
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D002453:Cell Cycle; D002467:Cell Nucleus / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D008938:Mitosis; D057054:Molecular Imaging; D013194:Staining and Labeling; D014230:Triazoles / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry*
chemical_list: C000605804:CDb12 compound; D005456:Fluorescent Dyes; D014230:Triazoles; D044004:Xanthones