title: Targeting L-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics.
abstract: BACKGROUND
  L-type amino acid transporter 1 (LAT1) is one of the amino acid transporters. It is overexpressed in various types of cancer cells, while it is produced restrictedly in normal tissues.
  
  
  METHODS
  We discuss its characteristics in cancer cells compared with normal cells. We also mention the current applications to target LAT1 for anticancer therapy focusing on prognostic biomarkers, radio-labeled tumor imaging reagents, amino acid-stapled prodrugs, LAT1-mediated enhanced transport of anticancer drugs and LAT1 inhibitors.
  
  
  CONCLUSIONS
  LAT1 can be a versatile target to promisingly develop transporter-based drugs with enhanced drug delivery potential for anticancer therapy.
authors.affiliation: a 1 Yonsei University, College of Pharmacy , Incheon, 406-840, Republic of Korea.
authors.forename: Su-Eon
authors.initials: SE
authors.lastname: Jin
authors.affiliation: b 2 University of California, Lawrence Berkeley National Laboratory, Department of Bioengineering, Berkeley and Physical Biosciences Division , Berkeley, CA 94720, USA.
authors.forename: Hyo-Eon
authors.initials: HE
authors.lastname: Jin
authors.affiliation: c 3 Inha University, College of Medicine, Department of Drug Development , Incheon, 400-712, Republic of Korea +82 32 890 3683 ; +82 32 890 2462 ; hongs@inha.ac.kr.
authors.forename: Soon-Sun
authors.initials: SS
authors.lastname: Hong
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D027283:Large Neutral Amino Acid-Transporter 1 / Q000378:metabolism*; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D027283:Large Neutral Amino Acid-Transporter 1
keywords: L-type amino acid transporter 1; anticancer drug; cancer; inhibitor; prodrug; prognostic biomarker; tumor imaging