title: Anal human papillomavirus and HIV: A cross-sectional study among men who have sex with men in Moscow, Russia, 2012-2013.
abstract: Anal human papillomavirus (HPV) is prevalent among men who have sex with men (MSM), but has not been studied in the Russian Federation. A cross-sectional survey and HPV genotyping were conducted among HIV seropositive (n=58) and seronegative MSM (n=65)in Moscow. Multivariable logistic regression was performed to identify correlates of infection with oncogenic HPV genotypes 16 and/or 18 (HPV 16/18). Forty per cent (49/124) of all MSM were infected with at least one anal HPV genotype, 31.5% (39/124) had HPV16/18,and 11.5% (14/121) had high-grade squamous intraepithelial lesions (HSIL). HPV 16/18 was more prevalent in HIV seropositive than seronegative men (24/58,41.4% vs 15/65, 23.1%; p=0.03). HIV infection was independently associated with HPV 16/18 (adjusted odds ratio (AOR): 5.08; 95% confidence intervals (CI):1.49-17.34, p=0.01), as was having 2-4 steady male sex partners in the last year (vs ≤ 1 partner; AOR: 6.99;95%CI: 1.94–25.24, p<0.01). History of prison/detention,migration to/within Russia and use of incompatible lubricants were marginally associated with HPV16/18 (p<0.10). Comprehensive prevention options are needed to address HIV and HPV infection among MSM in Russia and may benefit from inclusion of young men in piloted HPV vaccination programmes.
authors.affiliation: Department of Emergency Medicine, Johns Hopkins Medical Institute, Baltimore, MD, United States.
authors.forename: A L
authors.initials: AL
authors.lastname: Wirtz
authors.forename: C E
authors.initials: CE
authors.lastname: Zelaya
authors.forename: A
authors.initials: A
authors.lastname: Peryshkina
authors.forename: I
authors.initials: I
authors.lastname: McGowan
authors.forename: R D
authors.initials: RD
authors.lastname: Cranston
authors.forename: C
authors.initials: C
authors.lastname: Latkin
authors.forename: N
authors.initials: N
authors.lastname: Galai
authors.forename: V
authors.initials: V
authors.lastname: Mogilniy
authors.forename: P
authors.initials: P
authors.lastname: Dzhigun
authors.forename: I
authors.initials: I
authors.lastname: Kostetskaya
authors.forename: C
authors.initials: C
authors.lastname: Beyrer
mesh_terms: D000293:Adolescent; D000328:Adult; D001003:Anal Canal / Q000821:virology*; D001004:Anus Diseases / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology*; D060085:Coinfection / Q000453:epidemiology / Q000821:virology; D003430:Cross-Sectional Studies; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D018451:Homosexuality, Male / Q000706:statistics & numerical data*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009031:Moscow / Q000453:epidemiology; D015999:Multivariate Analysis; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology / Q000517:prevention & control / Q000821:virology; D015995:Prevalence; D012307:Risk Factors; D012725:Sexual Behavior; D011795:Surveys and Questionnaires; D055815:Young Adult