title: [Determination of phthalic acid esters plasticizer in food simulants by gas chromatography-mass spectrometry isotope dilution method].
abstract: OBJECTIVE
  The isotope dilution method for determination of 18 phthalic acid esters(PAEs) plasticizer in four kinds of food simulants were developed.
  
  
  METHODS
  18 PAEs were extracted by hexane in water, 3% (W/V) acetic acid and 20% ethanol of food stmulant. The 95% ethanol of food simulant was diluted to 20% ethanol by water and then was extracted by hexane.
  
  
  RESULTS
  The linear range of DINP and DIDP were 0.2 - 5.0 mg/L meanwhile the DMEP, DEEP and DBEP were 0.02 -2.0 mg/L, the other 13 PAEs were 0.005 -2.0 mg/L, the relative coefficients were greater more than 0.9991 by internal standard calibration. The limit of detection of 16PAEs were 0.1 - 6.7 μg/L, DIDP and DINP were 200.0 μg/L. The average recoveries were from 85.3% to 115.0% with RSD less than 10%.
  
  
  CONCLUSIONS
  Compared with the previous national standard method, the detection series of phthalic acid esters were expanded. The stability of the test results were solved in simulant 95% ethanol. The method is simple and repeatable by isotope dilution statutory quantitatively.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.forename: Ming
authors.initials: M
authors.lastname: Cui
authors.forename: Congrong
authors.initials: C
authors.lastname: Fang
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000085:Acetates; D002138:Calibration; D004952:Esters / Q000032:analysis*; D005502:Food; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D007554:Isotopes; D010795:Phthalic Acids / Q000032:analysis*; D010968:Plasticizers / Q000032:analysis*; D011865:Radioisotope Dilution Technique; D014867:Water
chemical_list: D000085:Acetates; D004952:Esters; D007554:Isotopes; D010795:Phthalic Acids; D010968:Plasticizers; D014867:Water