title: Erythropoietin dampens injury-induced microglial motility.
abstract: Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical tools that recombinant human EPO, a clinically established and neuroprotective growth factor, dampens microglial activity, as visualized also in vivo by a strongly attenuated injury-induced cellular motility.
authors.affiliation: Light Microscopy Facility, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors.forename: Miso
authors.initials: M
authors.lastname: Mitkovski
authors.affiliation: Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors.forename: Liane
authors.initials: L
authors.lastname: Dahm
authors.affiliation: Department of Cellular Neurobiology, Institute of Zoology, Georg-August-University, Göttingen, Germany.
authors.forename: Ralf
authors.initials: R
authors.lastname: Heinrich
authors.affiliation: Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Monnheimer
authors.affiliation: Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Gerhart
authors.affiliation: 1] Cellular and Molecular Neurobiology Group, Max Planck Institute of Experimental Medicine, Göttingen, Germany [2] Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany.
authors.forename: Judith
authors.initials: J
authors.lastname: Stegmüller
authors.affiliation: Institute of Neuropathology, Georg-August-University, Göttingen, Germany.
authors.forename: Uwe-Karsten
authors.initials: UK
authors.lastname: Hanisch
authors.affiliation: 1] Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany [2] Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
authors.forename: Klaus-Armin
authors.initials: KA
authors.lastname: Nave
authors.affiliation: 1] Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany [2] Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany.
authors.forename: Hannelore
authors.initials: H
authors.lastname: Ehrenreich
mesh_terms: D001930:Brain Injuries / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D004921:Erythropoietin / Q000494:pharmacology*; D006801:Humans; D017628:Microglia / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: C554270:EPO protein, human; D018696:Neuroprotective Agents; D011994:Recombinant Proteins; D004921:Erythropoietin