title: Maternal hyperglycemia and the 100-g oral glucose tolerance test.
abstract: OBJECTIVE
  To compare the characteristics of pregnant women with hyperglycemia according to the severity of glucose intolerance using the 100-g oral glucose tolerance test (OGTT) and to demonstrate the need to manage the condition of women with mild hyperglycemia.
  
  
  METHODS
  In this retrospective cohort study, a total of 258 women at high risk of gestational diabetes (GDM) based on a positive 50-g oral glucose challenge test (OGCT) were classified into 0+, 1+, 2+, 3+, and 4+ groups according to the number of abnormal plasma glucose values on the 100-g OGTT. The clinical characteristics of the groups were compared.
  
  
  RESULTS
  The rates of advanced maternal age (≥ 35 years), multiparity, prior history of GDM, preterm birth, cesarean delivery, and elevated body mass index were all positively correlated with the number of abnormal plasma glucose values on the OGTT (p < 0.05 for all variables). After adjusting for confounding factors, the fasting plasma glucose levels predicted birth weight in 44.4%, 48.4%, and 58.6% of the women in the positive 50-g OGCT group, the 0+ group, and the 1+ group, respectively. Weight gain during pregnancy predicted birth weight in 42%, 44.6%, and 37.6% of the women in the positive 50-g OGCT group, the 0+ group, and the 2+ group, respectively (p < 0.001 in each case).
  
  
  CONCLUSIONS
  These data demonstrate that the detection and management of mild hyperglycemia below the current diagnostic criteria of GDM as well as GDM diagnosed using the 100-g OGTT are necessary for improving pregnancy outcomes.
authors.affiliation: Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Tae-Chul
authors.initials: TC
authors.lastname: Park
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seoul National University, Seoul, South Korea.
authors.forename: Bang-Hyun
authors.initials: BH
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Errol R
authors.initials: ER
authors.lastname: Norwitz
authors.affiliation: Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, South Korea. Electronic address: heejoong@catholic.ac.kr.
authors.forename: Hee-Joong
authors.initials: HJ
authors.lastname: Lee
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
keywords: birth weight; gestational diabetes; hyperglycemia; plasma glucose