title: Interferon-alpha caused reversible parkinsonism.
abstract: Interferon has been used to treat chronic viral hepatitis and several malignancies. However, it may cause various neuropsychiatric adverse effects including parkinsonism. We report a rare case of interferon alpha-2a therapy-related parkinsonism in a 67-year-old man with metastatic papillary renal cell carcinoma and our experience of using Tc-99m-TRODAT-1 single photon emission computed tomography (SPECT) as a tool for evaluation of parkinsonism. Physicians should be alert to the possibility of interferon alpha-2a-related parkinsonism.
authors.affiliation: *Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan; †Division of Hematology/Oncology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center; ‡Division of Hematology/Oncology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei; §Division of Hematology/Oncology, Department of Internal Medicine, Buddhist Taipei Tzu Chi Hospital, Taipei; and ∥Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: Chieh-Sheng
authors.initials: CS
authors.lastname: Lu
authors.forename: Wei-Yau
authors.initials: WY
authors.lastname: Kao
authors.forename: Jiann-Chyun
authors.initials: JC
authors.lastname: Lin
authors.forename: Ping-Ying
authors.initials: PY
authors.lastname: Chang
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage / Q000009:adverse effects; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D015609:Organotechnetium Compounds; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014326:Tropanes
chemical_list: D007155:Immunologic Factors; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D015609:Organotechnetium Compounds; D011994:Recombinant Proteins; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1