title: Kinetics of endothelialization of the multilayer flow modulator and single-layer arterial stents.
abstract: The multilayer flow modulator (MFM; Cardiatis, Isnes, Belgium) is a self-expandable mesh of braided cobalt alloy wires, used for treatment of aortic and peripheral aneurysms. To further improve our understanding of this novel technology, the endothelialization kinetics of the MFM was investigated and compared with those of two marketed single-layer stents. Five porcine animal models were used in which a total of 19 stents were implanted in the iliac and carotid arteries between one and five weeks before sacrifice. All 19 stents were successfully delivered. For all devices, nonsignificant signs of inflammation or thrombosis were noted, and there was no evidence of local intolerance. The MFM developed a thin layer of endothelial cells earlier and was associated with less neointimal development than the two single-layer stents. A differing phenomenon of integration was also revealed and hypothesized as endothelialization from adhesion of circulating endothelial progenitor cells, as well as adhesion from the arterial wall, and also by the differences in trauma exposed to the arterial wall.
authors.affiliation: Department of Vascular and Endovascular Surgery, Western Vascular Institute, University Hospital Galway, Galway, Ireland Department of Vascular and Endovascular Surgery, Galway Clinic, Doughiska, Galway, Ireland sherif.sultan@hse.ie.
authors.forename: Sherif
authors.initials: S
authors.lastname: Sultan
authors.affiliation: Department of Vascular and Endovascular Surgery, Galway Clinic, Doughiska, Galway, Ireland.
authors.forename: Edel P
authors.initials: EP
authors.lastname: Kavanagh
authors.affiliation: Centre de Recherche en Imagerie Interventionnelle (CR2i), National Institute of Agronomic Research, Jouy-en-Josas, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Bonneau
authors.affiliation: Centre de Recherche en Imagerie Interventionnelle (CR2i), National Institute of Agronomic Research, Jouy-en-Josas, France.
authors.forename: Chantal
authors.initials: C
authors.lastname: Kang
authors.affiliation: NAMSA, Chasse-sur-Rhône, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Alves
authors.affiliation: Department of Vascular and Endovascular Surgery, Galway Clinic, Doughiska, Galway, Ireland.
authors.forename: Niamh M
authors.initials: NM
authors.lastname: Hynes
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000648:ultrastructure*; D042783:Endothelial Cells / Q000648:ultrastructure*; D057510:Endovascular Procedures / Q000009:adverse effects / Q000295:instrumentation*; D007083:Iliac Artery / Q000000981:diagnostic imaging / Q000648:ultrastructure*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D058426:Neointima; D011474:Prosthesis Design; D011859:Radiography; D062326:Re-Epithelialization; D015607:Stents; D013552:Swine
keywords: Multilayer flow modulator; endothelialization; kinetics; single layer; stent