title: Increased expression of the growth-associated protein-43 gene after primary motor cortex lesion in macaque monkeys.
abstract: We recently showed that changes of brain activity in the ipsilesional ventral premotor cortex (PMv) and perilesional primary motor cortex (M1) of macaque monkeys were responsible for recovery of manual dexterity after lesioning M1. To investigate whether axonal remodeling is associated with M1 lesion-induced changes in brain activity, we assessed gene expression of growth-associated protein-43 (GAP-43) in motor and premotor cortices. Increased expression was observed in the PMv during the period just after recovery and in the perilesional M1 during the plateau phase of recovery. Time-dependent and brain region-specific remodeling may play a role in functional recovery after lesioning M1.
authors.affiliation: Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Umezono, Tsukuba, Ibaraki 305-8568, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Murata
authors.affiliation: Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Umezono, Tsukuba, Ibaraki 305-8568, Japan; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan. Electronic address: n.higo@aist.go.jp.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Higo
authors.affiliation: Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan; Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Kanrin, Inuyama, Aichi 484-8506, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Oishi
authors.affiliation: Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan; Department of Developmental Physiology, National Institute for Physiological Sciences (NIPS), Okazaki, Aichi 444-8585, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Isa
mesh_terms: D000818:Animals; D005260:Female; D019922:GAP-43 Protein / Q000378:metabolism*; D006225:Hand / Q000503:physiopathology; D007051:Ibotenic Acid / Q000633:toxicity; D008251:Macaca; D008297:Male; D009044:Motor Cortex / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D009068:Movement; D013997:Time Factors
chemical_list: D019922:GAP-43 Protein; D007051:Ibotenic Acid
keywords: Functional recovery; In situ hybridization; Perilesional area; Plastic changes; Ventral premotor cortex