title: Antibacterial carboxymethyl cellulose/Ag nanocomposite hydrogels cross-linked with layered double hydroxides.
abstract: This paper deals with the preparation of antibacterial nanocomposite hydrogels through the combination of carboxy methyl cellulose (CMC), layered double hydroxides (LDH), and silver nanoparticles (AgNPs). CMC-LDH hydrogels were prepared by intercalating CMC into different LDHs. Then, Ag/CMC-LDH nanocomposite hydrogels were prepared through in situ formation of AgNPs within the CMC-LDHs. XRD analysis confirmed the intercalating CMC into the LDH sheets and formation of intercalated structures, as well as formation of AgNPs within the CMC-LDHs. SEM and TEM micrographs indicated well distribution of AgNPs within the Ag/CMC-LDHs. The prepared hydrogels showed a pH sensitive swelling behavior. The Ag/CMC-LDH nanocomposite hydrogels have rather higher swelling in different aqueous solutions in comparison with CMC-LDHs. The antibacterial activity of CMC-LDHs increased considerably after formation of AgNPs and was stable for more than one month.
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yadollahi
authors.affiliation: Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran; Research Center for Pharmaceutical Nanonotechnology, Tabriz University of Medical Science, Tabriz, Iran. Electronic address: namazi@tabrizu.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Namazi
authors.affiliation: Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aghazadeh
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry*; D052978:Disk Diffusion Antimicrobial Tests; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D020100:Hydrogels / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006878:Hydroxides / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D003432:Cross-Linking Reagents; D020100:Hydrogels; D006878:Hydroxides; D012834:Silver; D002266:Carboxymethylcellulose Sodium
keywords: Antibacterial; Carboxymethyl cellulose; Hydrogel; Layered double hydroxide; Silver nanoparticles