title: Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives.
abstract: In this study, series of novel bromophenol derivatives were synthesized and investigated for their antioxidant and AChE inhibition properties. Novel brominated diarylmethanones were obtained from the acylation reactions of benzoic acids with substituted benzenes. One of the bromodiarylmethanone was synthesized from the bromination of diarylmethanone with molecular bromine. All diarylmethanones were converted into their bromophenol derivatives with BBr3. The antioxidant activities of all synthesized compounds were elucidated by using various bioanalytical assays. Radical scavenging activities of compounds 10-24 were evaluated by means of DPPH and ABTS(+) scavenging activities. In addition, reducing ability of 10-24 were determined by Fe(3+), Cu(2+), and [Fe(3+)-(TPTZ)2](3) reducing activities. α-Tocopherol, trolox, BHA, and BHT were used as positive antioxidant and radical scavenger molecules. On the other hand, IC50 values were calculated for DPPH, ABTS(+) scavenging, and AChE inhibition effects of novel compounds. The results obtained from the current studies clearly show that novel bromophenol derivatives 20-24 have considerable antioxidant, antiradical, and AChE inhibition effects.
authors.affiliation: Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey.
authors.forename: Necla
authors.initials: N
authors.lastname: Öztaşkın
authors.affiliation: Oltu Vocational School, Department of Food Technology, Atatürk University, 25400 Oltu, Erzurum, Turkey.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Çetinkaya
authors.affiliation: Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey.
authors.forename: Parham
authors.initials: P
authors.lastname: Taslimi
authors.affiliation: Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey. Electronic address: sgoksu@atauni.edu.tr.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Göksu
authors.affiliation: Department of Chemistry, Faculty of Science, Atatürk University, 25240 Erzurum, Turkey; Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia. Electronic address: igulcin@atauni.edu.tr.
authors.forename: İlhami
authors.initials: İ
authors.lastname: Gülçin
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D002412:Cations / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D054879:Halogenation; D006801:Humans; D007501:Iron / Q000737:chemistry; D008745:Methylation; D010084:Oxidation-Reduction / Q000187:drug effects; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D002412:Cations; D002800:Cholinesterase Inhibitors; D016166:Free Radical Scavengers; D010636:Phenols; D003300:Copper; C032038:2-bromophenol; D007501:Iron; D000110:Acetylcholinesterase; D024502:alpha-Tocopherol
keywords: Acetylcholinesterase; Antioxidant activity; Bromophenols; Demethylation; Diarylmethanones; Enzyme inhibition