title: Convert and conquer: the strategy of chronic myelogenous leukemic cells.
abstract: Emerging evidence is contributing to explain how leukemias disrupt normal blood cell production. In this issue of Cancer Cell, Welner and colleagues show that, during the development of chronic myeloid leukemia, mutated cells transform normal hematopoietic progenitors into "leukemic like" cells through IL-6 secretion, proposing a new cellular target.
authors.affiliation: Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain; Stem Cell Institute and Department of Haematology, University of Cambridge and National Health Service Blood and Transplant, Cambridge Biomedical Campus, CB2 0PT Cambridge, UK. Electronic address: sm2116@cam.ac.uk.
authors.forename: Simón
authors.initials: S
authors.lastname: Méndez-Ferrer
authors.affiliation: Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: García-Fernández
authors.affiliation: Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain.
authors.forename: Carlos L F
authors.initials: CL
authors.lastname: de Castillejo
mesh_terms: D000818:Animals; D016207:Cytokines / Q000037:antagonists & inhibitors*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*
chemical_list: D016207:Cytokines