title: Conjugation of polymers to proteins through an inhibitor-derived peptide: taking up the inhibitor "berth".
abstract: A hexapeptide derived from an enzyme inhibitor was used as an affinity ligand for the conjugation of a hydrophilic polymer to the enzyme. The peptide targeted the polymer to the "berth" of the inhibitor in the enzyme, affording the enzyme resistance to the inhibitor without affecting the enzymatic activity.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Rd, Suzhou 215123, Jiangsu, P. R. China. chenh@suda.edu.cn lidan@suda.edu.cn.
authors.forename: Zengchao
authors.initials: Z
authors.lastname: Tang
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Yafei
authors.initials: Y
authors.lastname: Luan
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zhu
authors.forename: Hui
authors.initials: H
authors.lastname: Du
authors.forename: Yunwen
authors.initials: Y
authors.lastname: Tao
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Wang
authors.forename: David M
authors.initials: DM
authors.lastname: Haddleton
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D057927:Hydrophobic and Hydrophilic Interactions; D008024:Ligands; D051379:Mice; D008958:Models, Molecular; D009842:Oligopeptides / Q000737:chemistry*; D017395:Plasminogen Activator Inhibitor 1 / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry*; D011487:Protein Conformation; D051381:Rats; D010959:Tissue Plasminogen Activator / Q000037:antagonists & inhibitors* / Q000737:chemistry*
chemical_list: D008024:Ligands; D009842:Oligopeptides; D017395:Plasminogen Activator Inhibitor 1; D011108:Polymers; D010959:Tissue Plasminogen Activator