title: Changing incidence of myeloproliferative neoplasms: trends and subgroup risk profiles in the USA, 1973-2011.
abstract: OBJECTIVE
  Recent diagnostic and cancer reporting changes influencing myeloproliferative neoplasms (MPNs) encourage the assessment of trends and examination of the recently identified MPN subtypes: polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), across the age continuum by race and ethnicity.
  
  
  METHODS
  Surveillance, Epidemiology, and End Results data provided MPN incidence data since 1973 and MPN subtype data since 2001. Joinpoint regression estimated annual percent changes. Poisson regression estimated risk ratios.
  
  
  RESULTS
  The 2005 JAK2 V617F discovery and the 2008 WHO diagnostic guideline for the JAK2 V617F mutation coincide with a 31 % increase in ET and a 21 % decrease in PV incidence rates. We found that younger women had a 13-33 % higher ET risk and that women under the age of 34 had a 58 % higher PMF risk, relative to men. Blacks, aged 35-49 with a higher ET risk, also had a 69 % higher PMF risk relative to whites.
  
  
  CONCLUSIONS
  Demographic characteristic of ET and PMF patients may be useful for improving risk prediction and informing clinical screening and treatment strategies. Changing guidelines, new discoveries, and in-depth analysis of a large population-based study have implications for accurately identifying incident cases of MPNs, MPN subgroups, and health resource planning.
authors.affiliation: School of Community Health Sciences, University of Nevada, Mail Stop 274, 1664 North Virginia Street, Reno, NV, 89557, USA.|Biology Department, Truckee Meadows Community College, Mail Stop SIER 200S, 7000 Dandini Boulevard, Reno, NV, 89512, USA.
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Deadmond
authors.affiliation: School of Community Health Sciences, University of Nevada, Mail Stop 274, 1664 North Virginia Street, Reno, NV, 89557, USA. jsmithgagen@unr.edu.|Biology Department, Truckee Meadows Community College, Mail Stop SIER 200S, 7000 Dandini Boulevard, Reno, NV, 89512, USA. jsmithgagen@unr.edu.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Smith-Gagen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D053614:Janus Kinase 2 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D009367:Neoplasm Staging; D011087:Polycythemia Vera / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D055728:Primary Myelofibrosis / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D012307:Risk Factors; D018426:SEER Program; D013920:Thrombocythemia, Essential / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D013997:Time Factors; D014481:United States / Q000453:epidemiology
chemical_list: C507924:JAK2 protein, human; D053614:Janus Kinase 2
keywords: Essential thrombocythemia; Incidence; Myeloproliferative neoplasm; Polycythemia vera; Primary myelofibrosis; Trends