title: Relationship between maternal and newborn endothelial function and oxidative stress.
abstract: OBJECTIVE
  To evaluate the Relationship between maternal and newborn endothelial function and oxidative stress.
  
  
  METHODS
  Forty-three pregnant women and their offspring were evaluated. As markers of endothelial function, the flow-mediated dilation (FMD) was measured in pregnant women in the second and third trimesters, and nitric oxide (NO) was quantified in the endothelial cells of the umbilical cord vein. Malondialdehyde (MDA), as a marker of oxidative stress, was measured in the maternal plasma (second and third trimesters) and plasma from umbilical cord blood. Gestational age and birth weight were recorded. Correlations between variables were estimated, and adjustments were made for specific gestational week of measurement, gestational age at birth, and complications during pregnancy and/or at delivery.
  
  
  RESULTS
  Maternal FMD at second trimester correlated positively with newborn MDA, although with marginal significance (P = 0.090). The change in maternal FMD was positively correlated with newborn NO (P = 0.039), although adjustment for gestational age and specific week of gestation attenuated this relationship (P = 0.070). Maternal MDA at second trimester correlated positively with newborn MDA independently of gestational age at birth, specific week of gestation of the measurement, and having complications during pregnancy or at delivery (P = 0.032). After adjustments, the change in maternal MDA correlated with newborn MDA but marginally (P = 0.077).
  
  
  CONCLUSIONS
  Study findings suggest that under physiological conditions, enhanced endothelial function and/or oxidative stress in the mother may impact on normal fetal development. Future studies are recommended, employing larger sample sizes, a more extensive set of markers of oxidative stress, and comparisons of complicated versus normal pregnancies.
authors.affiliation: Faculty of Health Sciences, Universidad ICESI, Cali, Colombia.|Nutrition Group, Universidad del Valle, Cali, Colombia.
authors.forename: Isabella
authors.initials: I
authors.lastname: Echeverri
authors.affiliation: Nutrition Group, Universidad del Valle, Cali, Colombia.|Department of Basic Sciences, Research Group on Basic and Clinical Health Sciences, School of Medicine, Pontificia Universidad Javeriana, Cali, Colombia.
authors.forename: José Guillermo
authors.initials: JG
authors.lastname: Ortega-Ávila
authors.affiliation: Nutrition Group, Universidad del Valle, Cali, Colombia.|Department of Physiological Sciences, Universidad del Valle, Cali, Colombia.
authors.forename: Mildrey
authors.initials: M
authors.lastname: Mosquera
authors.affiliation: Department of Biological Sciences, Faculty of Natural Sciences, Universidad ICESI, Cali, Colombia.
authors.forename: Andrés
authors.initials: A
authors.lastname: Castillo
authors.affiliation: Nutrition Group, Universidad del Valle, Cali, Colombia.|Department of Physiological Sciences, Universidad del Valle, Cali, Colombia.
authors.forename: Eliécer
authors.initials: E
authors.lastname: Jiménez
authors.affiliation: Nutrition Group, Universidad del Valle, Cali, Colombia.|Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom.
authors.forename: Milton Fabian
authors.initials: MF
authors.lastname: Suárez-Ortegon
authors.affiliation: School of Public Health, Universidad del Valle, Cali, Colombia.|Fundación FES, Cali, Colombia.
authors.forename: Julio Cesar
authors.initials: JC
authors.lastname: Mateus
authors.affiliation: Nutrition Group, Universidad del Valle, Cali, Colombia.|Department of Physiological Sciences, Universidad del Valle, Cali, Colombia.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Aguilar-de Plata
mesh_terms: D000293:Adolescent; D015415:Biomarkers; D001724:Birth Weight; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000096:biosynthesis*; D018384:Oxidative Stress / Q000502:physiology*; D011247:Pregnancy; D014470:Umbilical Cord / Q000098:blood supply*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide; D008315:Malondialdehyde