title: The Role of Oxidative Stress in Gastrointestinal Tract Tissues Induced by Arsenic Toxicity in Cocks.
abstract: Arsenic (As) is a widely distributed trace element which is known to be associated with numerous adverse effects on human beings and animals. Arsenic trioxide (As2O3) is an inorganic arsenical-containing toxic compound. The effect of excessive amounts of As2O3 exposure on gastrointestinal tract tissue damage in cocks is still unknown. This study was conducted to investigate the effect of As2O3 exposure on gastrointestinal tract tissue damage in cocks. In total, 72 1-day-old male Hyline cocks were randomly divided into four groups and fed either a commercial diet or an As2O3 supplement diet containing 7.5, 15, and 30 mg/kg As2O3. The experiment lasted for 90 days and gastrointestinal tract tissue samples (gizzard, glandular stomach, duodenum, jejunum, ileum, cecum, and rectum) were collected at 30, 60, and 90 days. Catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px) activities; malondialdehyde (MDA) contents; and hydroxyl radical (OH·)-mediated inhibition were examined. Furthermore, the results demonstrated that MDA content in the gastrointestinal tract was increased, while the activities of CAT, GSH, and GSH-Px and the ability to resist OH· was decreased in the As2O3 treatment groups. Extensive damage was observed in the gastrointestinal tract. These findings indicated that As2O3 exposure caused oxidative damage in the gastrointestinal tract of cocks due to alterations in antioxidant enzyme activities and elevation of free radicals.
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin, 150040, Heilongjiang Province, China. guoying0601@sina.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin, 150040, Heilongjiang Province, China. zpp13796033057@163.com.
authors.forename: Panpan
authors.initials: P
authors.lastname: Zhao
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin, 150040, Heilongjiang Province, China.
authors.forename: Guangyang
authors.initials: G
authors.lastname: Guo
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin, 150040, Heilongjiang Province, China.
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Hu
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin, 150040, Heilongjiang Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin, 150040, Heilongjiang Province, China.
authors.forename: Kexin
authors.initials: K
authors.lastname: Zhang
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin, 150040, Heilongjiang Province, China. zhangwenwakeup@126.com.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: College of Wildlife Resources, Northeast Forestry University, Harbin, 150040, Heilongjiang Province, China. xingmingweinefu@sina.com.
authors.forename: Mingwei
authors.initials: M
authors.lastname: Xing
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D020261:Arsenic Poisoning; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000737:chemistry; D002374:Catalase / Q000378:metabolism; D002645:Chickens; D005609:Free Radicals; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000473:pathology*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D017665:Hydroxyl Radical; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D010087:Oxides / Q000737:chemistry / Q000633:toxicity*; D014131:Trace Elements
chemical_list: D000975:Antioxidants; D001152:Arsenicals; D005609:Free Radicals; D010087:Oxides; D014131:Trace Elements; D017665:Hydroxyl Radical; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D005978:Glutathione; D000077237:Arsenic Trioxide
keywords: Arsenic toxicity; Cocks; Gastrointestinal tract tissues; Oxidative damage