title: The kinetics of donor HLA class I-specific antibody absorption following a combined split liver and kidney transplant.
abstract: Hyperacute rejection of a transplanted liver is rare even when the recipient has circulating donor-specific alloantibodies (DSA). There is also evidence that a transplanted liver may provide immunological protection for other organs transplanted from the same donor. We monitored the kinetics of circulating DSA in a highly sensitized recipient of a combined split liver and kidney transplant and demonstrated a reduction in antibody titres immediately after liver perfusion. The absorption of DSA was not compromised by the smaller liver mass transplanted. DSA titres remained low at 3 months post-transplant, and the recipient did not experience antibody-mediated rejection.
authors.affiliation: Tissue Typing Laboratory.
authors.forename: Tim
authors.initials: T
authors.lastname: Key
authors.affiliation: Department of Surgery.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Watson
authors.affiliation: Division of Renal Medicine , Cambridge University Hospitals NHS Foundation Trust , Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ UK.
authors.forename: Menna R
authors.initials: MR
authors.lastname: Clatworthy
authors.affiliation: Tissue Typing Laboratory.
authors.forename: Cheryl M
authors.initials: CM
authors.lastname: O'Rourke
authors.affiliation: Tissue Typing Laboratory.
authors.forename: Reyna S
authors.initials: RS
authors.lastname: Goodman
authors.affiliation: Tissue Typing Laboratory.
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Taylor
authors.affiliation: Department of Surgery.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Butler
keywords: HLA-specific antibody; hyperacute rejection; liver–kidney transplant