title: Dual roles of TLR7 in the lung cancer microenvironment.
abstract: Toll-like receptor 7 (TLR7) agonists are under investigation for their ability to enhance antitumor immune responses. However, these agonists can also stimulate TLR7-expressing tumor cells. High TLR7 expression in the primary tumor confers poor clinical outcome and resistance to chemotherapy in lung cancer patients. This protumorigenic effect of TLR7 has been validated in murine models of lung carcinoma.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM); UMRS1138; Centre de Recherche des Cordeliers ; Paris, France ; Université Pierre et Marie Curie-Paris 6; UMRS1138 ; Paris France ; Université Paris Descartes; UMRS1138 ; Paris, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Dajon
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM); UMRS1138; Centre de Recherche des Cordeliers ; Paris, France ; Université Pierre et Marie Curie-Paris 6; UMRS1138 ; Paris France ; Université Paris Descartes; UMRS1138 ; Paris, France.
authors.forename: Kristina
authors.initials: K
authors.lastname: Iribarren
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM); UMRS1138; Centre de Recherche des Cordeliers ; Paris, France ; Université Pierre et Marie Curie-Paris 6; UMRS1138 ; Paris France ; Université Paris Descartes; UMRS1138 ; Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cremer
keywords: MDSC; TLR7; chemoresistance; lung cancer