title: Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population.
abstract: The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to tumor promotion in the mammary gland. We examined the role of the C677T polymorphism in the MTHFR gene by comparing the C677T genotypes of 339 healthy Mexican women with those of 497 Mexican women with breast cancer (BC). The genotype frequencies observed in the controls and patients with BC were 10 and 21% for 677TT; 41 and 36% for 677CT; and 49 and 43% for 677CC, respectively. The odds ratio (OR) for the 677TT genotype was 2.5, with a 95% confidence interval (95%CI) of 1.6-3.8; P = 0.0001. The positive association was also evident when the distributions of the 677TT genotype in control and patients affected within the following two categories were compared to alcohol consumption (OR = 0.41; 95%CI = 0.19-0.86; P = 0.018); and high level glutamate-oxaloacetate transaminase (SGOT) (OR = 0.36; 95%CI = 0.15-0.83, P = 0.017). These results suggest that the 677TT genotype of the C677T polymorphism in the MTHFR gene is associated with BC susceptibility in the Mexican population.
authors.affiliation: Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Ramos-Silva
authors.affiliation: Genetics Division, Western Biomedical Research Center, Western National Medical Center, Guadalajara, Jalisco, México.
authors.forename: L E
authors.initials: LE
authors.lastname: Figuera
authors.affiliation: Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: O M
authors.initials: OM
authors.lastname: Soto-Quintana
authors.affiliation: Inmmunopharmacology Laboratory, Exact and Engineering Sciences University Center, University of Guadalajara, Guadalajara, Jalisco, México.
authors.forename: A M
authors.initials: AM
authors.lastname: Puebla-Pérez
authors.affiliation: Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Ramírez-Patiño
authors.affiliation: Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: I
authors.initials: I
authors.lastname: Gutiérrez-Hurtado
authors.affiliation: Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: D I
authors.initials: DI
authors.lastname: Carrillo-Moreno
authors.affiliation: Mutagenesis Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: G M
authors.initials: GM
authors.lastname: Zúñiga-González
authors.affiliation: Genetics Division, Western Biomedical Research Center, Western National Medical Center, Guadalajara, Jalisco, México.
authors.forename: I P
authors.initials: IP
authors.lastname: Dávalos-Rodríguez
authors.affiliation: Genetics Molecular Laboratory, Molecular Medicine Division, Western Biomedical Research Center, Western National Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico marthapatriciagallegos08@gmail.com.
authors.forename: M P
authors.initials: MP
authors.lastname: Gallegos-Arreola
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008800:Mexico; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055815:Young Adult
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)