title: Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension.
authors.affiliation: From Division of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City (J.J.R.); and Department of Medicine, Queen's University, Kingston, ON, Canada (S.L.A.).
authors.forename: John J
authors.initials: JJ
authors.lastname: Ryan
authors.affiliation: From Division of Cardiovascular Medicine, Department of Medicine, University of Utah, Salt Lake City (J.J.R.); and Department of Medicine, Queen's University, Kingston, ON, Canada (S.L.A.). stephen.archer@queensu.ca.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Archer
mesh_terms: D000222:Adaptation, Physiological; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D004195:Disease Models, Animal; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D006019:Glycolysis; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology; D006352:Heart Ventricles / Q000378:metabolism; D006801:Humans; D006976:Hypertension, Pulmonary / Q000378:metabolism* / Q000503:physiopathology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000502:physiology; D008929:Mitochondria, Heart / Q000502:physiology*; D063154:Mitochondrial Dynamics; D010100:Oxygen / Q000097:blood; D011652:Pulmonary Circulation; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D000099156:Superoxide Dismutase 2
chemical_list: D000255:Adenosine Triphosphate; D005227:Fatty Acids; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D010100:Oxygen; D011768:Pyruvate Dehydrogenase Complex; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C497442:HIF1A protein, human
keywords: glucose oxidation; glycolysis; heart failure; hypertension, pulmonary; mitochondria; mitochondrial dynamics; positron emission tomography