title: Alterations of left ventricular deformation and cardiac sympathetic derangement in patients with systolic heart failure: a 3D speckle tracking echocardiography and cardiac ¹²³I-MIBG study.
abstract: OBJECTIVE
  Myocardial contractile function is under the control of cardiac sympathetic activity. Three-dimensional speckle tracking echocardiography (3D-STE) and cardiac imaging with (123)I-metaiodobenzylguanidine ((123)I-MIBG) are two sophisticated techniques for the assessment of left ventricular (LV) deformation and sympathetic innervation, respectively, which offer important prognostic information in patients with heart failure (HF). The purpose of this investigation was to explore, in patients with systolic HF, the relationship between LV deformation assessed by 3D-STE and cardiac sympathetic derangement evaluated by (123)I-MIBG imaging.
  
  
  METHODS
  We prospectively studied 75 patients with systolic HF. All patients underwent a 3D-STE study (longitudinal, circumferential, area and radial) and (123)I-MIBG planar and SPECT cardiac imaging.
  
  
  RESULTS
  3D-STE longitudinal, circumferential and area strain values were correlated with (123)I-MIBG late heart to mediastinum (H/M) ratio and late SPECT total defect score. After stratification of the patients according to ischaemic or nonischaemic HF aetiology, we observed a good correlation of all 3D-STE measurements with late H/M ratio and SPECT data in the ischaemic group, but in patients with HF of nonischaemic aetiology, no correlation was found between LV deformation and cardiac sympathetic activity. At the regional level, the strongest correlation between LV deformation and adrenergic innervation was found for the left anterior descending coronary artery distribution territory for all four 3D-STE values. In multivariate linear regression analyses, including age, gender, LV ejection fraction, NYHA class, body mass index, heart rate and HF aetiology, only 3D-STE area and radial strain values significantly predicted cardiac sympathetic derangement on (123)I-MIBG late SPECT.
  
  
  CONCLUSIONS
  This study indicated that 3D-STE measurements are correlated with (123)I-MIBG planar and SPECT data. Furthermore, 3D-STE area and radial strain values, but not LVEF, predict cardiac sympathetic derangement in human postischaemic HF.
authors.affiliation: Department of Translational Medical Science, University Federico II, Via S. Pansini 5, 80131, Naples, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Leosco
authors.forename: Valentina
authors.initials: V
authors.lastname: Parisi
authors.forename: Teresa
authors.initials: T
authors.lastname: Pellegrino
authors.forename: Gennaro
authors.initials: G
authors.lastname: Pagano
authors.forename: Grazia Daniela
authors.initials: GD
authors.lastname: Femminella
authors.forename: Agnese
authors.initials: A
authors.lastname: Bevilacqua
authors.forename: Stefania
authors.initials: S
authors.lastname: Paolillo
authors.forename: Roberto
authors.initials: R
authors.lastname: Formisano
authors.forename: Gaetana
authors.initials: G
authors.lastname: Ferro
authors.forename: Claudio
authors.initials: C
authors.lastname: de Lucia
authors.forename: Maria
authors.initials: M
authors.lastname: Prastaro
authors.forename: Pasquale Perrone
authors.initials: PP
authors.lastname: Filardi
authors.forename: Alberto
authors.initials: A
authors.lastname: Cuocolo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rengo
authors.forename: Nicola
authors.initials: N
authors.lastname: Ferrara
mesh_terms: D019797:3-Iodobenzylguanidine; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine