title: Fucofullerenes as tight ligands of RSL and LecB, two bacterial lectins.
abstract: A series of water-soluble glycofullerenes containing up to 24 fucose residues have been prepared. These compounds were tested against the two bacterial fucose-binding lectins LecB and RSL, and C60(E)12 bearing 24 fucose residues appeared to be the best known inhibitor of both lectins to date. We have shown that increasing both the valency and the length of the spacer between the central core and the peripheral sugars can be beneficial for the affinity.
authors.affiliation: University of Namur (UNamur), Académie Louvain, Département de Chimie, Laboratoire de Chimie Bio-Organique, rue de Bruxelles 61, B-5000 Namur, Belgium. stephane.vincent@unamur.be.
authors.forename: Kevin
authors.initials: K
authors.lastname: Buffet
authors.forename: Emilie
authors.initials: E
authors.lastname: Gillon
authors.forename: Michel
authors.initials: M
authors.lastname: Holler
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Nierengarten
authors.forename: Anne
authors.initials: A
authors.lastname: Imberty
authors.forename: Stéphane P
authors.initials: SP
authors.lastname: Vincent
mesh_terms: D002151:Calorimetry / Q000379:methods; D060326:Chemistry Techniques, Synthetic; D005643:Fucose / Q000737:chemistry; D037741:Fullerenes / Q000737:chemistry* / Q000378:metabolism*; D037102:Lectins / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D037741:Fullerenes; C534600:LecB protein, Pseudomonas aeruginosa; D037102:Lectins; D008024:Ligands; C027112:fucose-binding lectin; D005643:Fucose; C069837:fullerene C60