title: Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis.
abstract: Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment, but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but tertiary healthcare is the most common entry point for patients into the system. These factors require special attention from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases.
authors.affiliation: Centro de Laboratório Regional de São José do Rio Preto, Instituto Adolfo Lutz, São José do Rio Preto, SP, Brasil.
authors.forename: Heloisa da Silveira Paro
authors.initials: Hda S
authors.lastname: Pedro
authors.affiliation: Centro de Laboratório Regional de São José do Rio Preto, Instituto Adolfo Lutz, São José do Rio Preto, SP, Brasil.
authors.forename: Susilene Maria Tonelli
authors.initials: SM
authors.lastname: Nardi
authors.affiliation: Centro de Laboratório Regional de São José do Rio Preto, Instituto Adolfo Lutz, São José do Rio Preto, SP, Brasil.
authors.forename: Maria Izabel Ferreira
authors.initials: MI
authors.lastname: Pereira
authors.affiliation: Instituto Adolfo Lutz Central, São Paulo, SP, Brasil.
authors.forename: Rosângela Siqueira
authors.initials: RS
authors.lastname: Oliveira
authors.affiliation: Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
authors.forename: Philip Noel
authors.initials: PN
authors.lastname: Suffys
authors.affiliation: Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
authors.forename: Harrison Magdinier
authors.initials: HM
authors.lastname: Gomes
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Amanda Juliane
authors.initials: AJ
authors.lastname: Finardi
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Eloise Brasil de
authors.initials: EB
authors.lastname: Moraes
authors.affiliation: Instituto Lauro de Souza Lima, Bauru, SP, Brasil.
authors.forename: Ida Maria Foschiani Dias
authors.initials: IM
authors.lastname: Baptista
authors.affiliation: Departamento de Genética, Universidade Estadual Paulista Júlio de Mesquita Filho, São José do Rio Preto, SP, Brasil.
authors.forename: Ricardo Luiz Dantas
authors.initials: RL
authors.lastname: Machado
authors.affiliation: Departamento de Genética, Universidade Estadual Paulista Júlio de Mesquita Filho, São José do Rio Preto, SP, Brasil.
authors.forename: Lilian
authors.initials: L
authors.lastname: Castiglioni
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D060085:Coinfection / Q000188:drug therapy / Q000453:epidemiology; D003430:Cross-Sectional Studies; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000187:drug effects*; D012959:Socioeconomic Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents