title: A randomized controlled trial of the effects of vitamin D supplementation on arterial stiffness and aortic blood pressure in Native American women.
abstract: OBJECTIVE
  It is unclear if vitamin D supplementation improves central blood pressure or arterial stiffness in Native American (NA) women.
  
  
  METHODS
  Healthy postmenopausal NA women were randomized to receive 400 IU or 2500 IU of vitamin D for 6 months. Central systolic blood pressure (cSBP), central pulse pressure (cPP) and aortic augmentation index (AIx) were estimated by tonometry at baseline and after 6 months.
  
  
  RESULTS
  Study volunteers (n = 98) were 61 (7.3) years old. 25(OH)D was 26.4 (11.0) ng/mL. 25(OH)D was similar between the two treatment groups (p = 0.291), as were baseline cSBP, cPP, and CVD risk factors (all p > 0.1). Treatment with 2500 IU of daily vitamin D3 did not affect cSBP, cPP, or AIx (all p > 0.1) compared to 400 IU daily.
  
  
  CONCLUSIONS
  Despite low serum 25(OH)D at baseline, 6 months of vitamin D supplementation did not improve central blood pressure parameters or arterial stiffness in NA women. CLINICAL TRIALS.
  NCT01490333.
authors.affiliation: University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Gepner
authors.affiliation: Essentia Institute of Rural Health, Duluth, MN, USA.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Haller
authors.affiliation: University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Diane C
authors.initials: DC
authors.lastname: Krueger
authors.affiliation: University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Claudia E
authors.initials: CE
authors.lastname: Korcarz
authors.affiliation: University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Binkley
authors.affiliation: University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address: jhs@medicine.wisc.edu.
authors.forename: James H
authors.initials: JH
authors.lastname: Stein
mesh_terms: D000368:Aged; D062186:Arterial Pressure / Q000187:drug effects*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology / Q000503:physiopathology; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007198:Indians, North American; D008365:Manometry; D008875:Middle Aged; D017698:Postmenopause; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D059289:Vascular Stiffness / Q000187:drug effects*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology
chemical_list: D015415:Biomarkers; D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Arterial stiffness; Cardiovascular disease risk; Central blood pressure; Vitamin D