title: Associations of colorectal cancer incidence with nutrient and food group intakes in korean adults: a case-control study.
abstract: This study aimed to examine the associations between intakes of various nutrients and food groups and colorectal cancer risk in a case-control study among Koreans aged 20 to 80 years. A total of 150 new cases and 116 controls were recruited with subjects' informed consent. Dietary data were collected using the food frequency questionnaire developed and validated by the Korea Centers for Disease Control and Prevention. Multivariate logistic regression models were used to estimate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for colorectal cancer incidence. High intakes of total lipid (ORT3 vs T1 = 4.15, 95% CI: 1.33-12.96, p for trend = 0.034), saturated fatty acid (ORT3 vs T1 = 2.96, 95% CI: 1.24-7.04, p for trend = 0.016) and monounsaturated fatty acid (ORT3 vs T1 = 3.04, 95% CI: 1.23-7.54, p for trend = 0.018) were significantly associated with increased incidence of colorectal cancer. High dietary fiber (ORT3 vs T1 = 0.22, 95% CI: 0.08-0.56, p for trend = 0.002) and vitamin C (ORT3 vs T1 = 0.38, 95% CI: 0.14-1.05, p for trend = 0.021) intakes were significantly associated with reduced colorectal cancer incidence. From the food group analysis, bread (ORT3 vs T1 = 2.26, 95% CI: 0.96-5.33, p for trend = 0.031), red meat (ORT3 vs T1 = 7.33, 95% CI: 2.98-18.06, p for trend < 0.001), milk·dairy product (ORT3 vs T1 = 2.42, 95% CI: 1.10-5.31, p for trend = 0.071) and beverage (ORT3 vs T1 = 3.17, 95% CI: 1.35-7.48, p for trend = 0.002) intakes were positively associated with colorectal cancer risk. On the other hand, high intake of traditional rice cake (ORT3 vs T1 = 0.35, 95% CI: 0.14-0.86, p for trend = 0.024) was linked with lower colorectal cancer incidence. In conclusion, eating a diet high in total lipid, saturated fatty acids and monounsaturated fatty acids is associated with higher incidence of colorectal cancer, whereas a diet high in dietary fiber and vitamin C was found to lower the incidence in Korean adults. Interestingly high traditional rice cake consumption is associated inversely with colorectal cancer incidence, warranting a future study.
authors.affiliation: Department of Food and Nutrition, Sungshin Women's University, Seoul 142-732, Korea.
authors.forename: Yu Jeong
authors.initials: YJ
authors.lastname: Chun
authors.affiliation: Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea.
authors.forename: Seung-Kook
authors.initials: SK
authors.lastname: Sohn
authors.affiliation: Colorectal Cancer Clinic/Division of Nursing, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea.
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Song
authors.affiliation: Department of Nutrition Services, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea.
authors.forename: Song Mi
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Gastroenterology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea.
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Youn
authors.affiliation: Department of Food and Nutrition, Sungshin Women's University, Seoul 142-732, Korea.
authors.forename: Seungmin
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Gastroenterology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, Korea.
authors.forename: Hyojin
authors.initials: H
authors.lastname: Park
keywords: Case-control study; Colorectal cancer; Food group; Nutrient