title: In situimmunization via non-surgical ablation to prevent local and distant tumor recurrence.
abstract: Host immunities are induced during cryoablation or oncolytic adenovirus therapy when the entire repertoire of tumor associated antigens (TAA) is released. Local and systemic protection is enhanced by the combined treatment with toll-like receptor agonist or immune stimulating cytokines. Non-surgical tumor ablation is an effective platform forin situimmunization.
authors.affiliation: Karmanos Cancer Institute; Wayne State University ; Detroit, MI, USA.
authors.forename: Jesse J
authors.initials: JJ
authors.lastname: Veenstra
authors.affiliation: Karmanos Cancer Institute; Wayne State University ; Detroit, MI, USA.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Gibson
authors.affiliation: Department of Radiation Oncology; Henry Ford Health System ; Detroit, MI, USA.
authors.forename: Svend
authors.initials: S
authors.lastname: Freytag
authors.affiliation: Karmanos Cancer Institute; Wayne State University ; Detroit, MI, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Littrup
authors.affiliation: Karmanos Cancer Institute; Wayne State University ; Detroit, MI, USA.
authors.forename: Wei-Zen
authors.initials: WZ
authors.lastname: Wei
keywords: CpG; GM-CSF; Her2/neu; IL-12; adenovirus; cryoablation; immunization; mouse mammary tumor; suicide gene