title: Delivering vaccines to the people who need them most.
abstract: Thanks to the Global Alliance for Vaccines and Immunization (GAVI), the Vaccine Fund and the Bill & Melinda Gates Foundation, the global health community has made enormous progress in providing already existing vaccines to developing countries. However, there still exists a gap to develop vaccines for which there is no market in the Western world, owing to low economic incentives for the private sector to justify the investments necessary for vaccine development. In many cases, industry has the technologies, but lacks the impetus to direct resources to develop these vaccine products. The present emergency with the Ebola vaccine provides us an excellent example where a vaccine was feasible several years ago, but the global health community waited for a humanitarian disaster to direct efforts and resources to develop this vaccine. In the beginning of 2015, the first large-scale trials of two experimental vaccines against Ebola virus disease have begun in West Africa. During the past few years, several institutions have dedicated efforts to the development of vaccines against diseases present only in low-income countries. These include the International Vaccine Institute, the Novartis Vaccines Institute for Global Health, the Hilleman Institute, the Sabin Vaccine Institute and the Infectious Disease Research Institute. Nevertheless, solving this problem requires a more significant global effort than that currently invested. These efforts include a clear policy, global coordination of funds dedicated to the development of neglected disease and an agreement on regulatory strategies and incentives for the private sector.
authors.affiliation: Novartis Vaccines and Diagnostics, Siena, Italy.
authors.forename: Michèle Anne
authors.initials: MA
authors.lastname: Barocchi
authors.affiliation: Novartis Vaccines and Diagnostics, Siena, Italy rino.rappuoli@novartis.com.
authors.forename: Rino
authors.initials: R
authors.lastname: Rappuoli
mesh_terms: D003906:Developing Countries; D004345:Drug Industry; D006077:Government Agencies; D006292:Health Priorities; D006801:Humans; D017589:Immunization Programs / Q000191:economics; D014612:Vaccines / Q000008:administration & dosage / Q000191:economics*
chemical_list: D014612:Vaccines
keywords: GAVI; HIC; LMIC; global health; neglected diseases; vaccine technology