title: A Novel Operative Procedure for Pelvic Organ Prolapse Utilizing a MRI-Visible Mesh Implant: Safety and Outcome of Modified Laparoscopic Bilateral Sacropexy.
abstract: BACKGROUND
  Sacropexy is a generally applied treatment of prolapse, yet there are known possible complications of it. An essential need exists for better alloplastic materials.
  
  
  METHODS
  Between April 2013 and June 2014, we performed a modified laparoscopic bilateral sacropexy (MLBS) in 10 patients using a MRI-visible PVDF mesh implant. Selected patients had prolapse POP-Q stages II-III and concomitant OAB. We studied surgery-related morbidity, anatomical and functional outcome, and mesh-visibility in MRI. Mean follow-up was 7.4 months.
  
  
  RESULTS
  Concomitant colporrhaphy was conducted in 1/10 patients. Anatomical success was defined as POP-Q stage 0-I. Apical success rate was 100% and remained stable. A recurrent cystocele was seen in 1/10 patients during follow-up without need for intervention. Out of 6 (6/10) patients with preoperative SUI, 5/6 were healed and 1/6 persisted. De-novo SUI was seen in 1/10 patients. Complications requiring a relaparoscopy were seen in 2/10 patients. 8/10 patients with OAB were relieved postoperatively. The first in-human magnetic resonance visualization of a prolapse mesh implant was performed and showed good quality of visualization.
  
  
  CONCLUSIONS
  MLBS is a feasible and safe procedure with favorable anatomical and functional outcome and good concomitant healing rates of SUI and OAB. Prospective data and larger samples are required.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital Homburg, Kirrberger Straße 100, 66424 Homburg, Germany.
authors.forename: Ralf
authors.identifier: 0000-0002-0127-480X
authors.initials: R
authors.lastname: Joukhadar
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital Homburg, Kirrberger Straße 100, 66424 Homburg, Germany.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Meyberg-Solomayer
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital Homburg, Kirrberger Straße 100, 66424 Homburg, Germany.
authors.forename: Amr
authors.identifier: 0000-0003-3630-0593
authors.initials: A
authors.lastname: Hamza
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital Homburg, Kirrberger Straße 100, 66424 Homburg, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Radosa
authors.affiliation: Department of Obstetrics and Gynecology, Klinikum Bielefeld, Teutoburger Straße 50, 33604 Bielefeld, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Bader
authors.affiliation: Department of Urology, Lukaskrankenhaus GmbH, Preußenstraße 84, 41464 Neuss, Germany.
authors.forename: Dimitri
authors.identifier: 0000-0001-8611-8250
authors.initials: D
authors.lastname: Barski
authors.affiliation: Department of Gynecology, University Hospital Charité, Campus Virchow-Klinikum (CVK), Mittelallee 9, 13353 Berlin, Germany.
authors.forename: Fakher
authors.identifier: 0000-0003-4653-9653
authors.initials: F
authors.lastname: Ismaeel
authors.affiliation: Department of Radiology, University Hospital Homburg, Kirrberger Straße 100, 66424 Homburg, Germany.
authors.forename: Guenther
authors.initials: G
authors.lastname: Schneider
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital Homburg, Kirrberger Straße 100, 66424 Homburg, Germany.
authors.forename: Erich
authors.initials: E
authors.lastname: Solomayer
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital Homburg, Kirrberger Straße 100, 66424 Homburg, Germany.
authors.forename: Sascha
authors.identifier: 0000-0001-6057-6042
authors.initials: S
authors.lastname: Baum
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000503:physiopathology*; D011446:Prospective Studies; D013526:Surgical Mesh / Q000009:adverse effects; D016896:Treatment Outcome