title: Clinical observation of umbilical cord mesenchymal stem cell treatment of severe systolic heart failure.
abstract: The aim of this study was to evaluate the effectiveness of umbilical cord mesenchymal stem cells (MSCs) in the treatment of chronic systolic heart failure. Fifty-nine hospitalized patients with heart failure were randomly divided into a treatment group (30 patients) and a control group (29 patients). The treatment group received treatment with medication as well as intracoronary transplantation of umbilical cord MSCs, and the control group, only medication. The cardiac structure, function change, and rehospitalization and mortality rates of the 2 groups were observed before and 1 and 6 months after treatment. One month after the transplantation of umbilical cord MSCs, the incidence of fatigue, chest tightness, and dyspnea was high in the treatment group. The 6-min walking distance of the treatment group was found to be significantly higher than that of the control group (P < 0.05); in addition, the NT-proBNP level, left ventricular ejection fraction, and mortality rate of the treatment group were statistically lower than those of the control group (P < 0.05). Readmission rates showed a downward trend, but the difference was not statistically significant (P > 0.05). Using umbilical cord MSCs in the treatment of congestive heart failure can help improve cardiac remodeling and cardiac function and reduce the mortality rate.
authors.affiliation: Department of Internal Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Zhao
authors.affiliation: Department of Internal Medicine, Henan Provincial People's Hospital, Zhengzhou, China yxxfcn@126.com.
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Internal Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhu
authors.affiliation: Department of Internal Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Gao
authors.affiliation: Department of Internal Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
authors.forename: Y N
authors.initials: YN
authors.lastname: Shi
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D054143:Heart Failure, Systolic / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D006334:Heart Function Tests; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D020127:Recovery of Function; D014470:Umbilical Cord / Q000166:cytology*; D055815:Young Adult
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain