title: Human papilloma virus-related oropharyngeal cancer: opportunities and challenges in dysphagia management.
abstract: OBJECTIVE
  Human papilloma virus (HPV) has emerged as the most common cause of oropharyngeal cancer (OPC) compared with traditional causes of excess alcohol and tobacco use. In this article, we will discuss HPV-related OPC and the challenges and opportunities presented in dysphagia management relative to efforts to de-escalate treatment and improve outcomes.
  
  
  RESULTS
  It is becoming increasingly apparent that patients with HPV-positive disease appear to respond favourably to chemoradiation. Targeted chemoradiation is associated with severe early and late toxicities related to swallow function. Research is in progress to ascertain the benefit of treatment de-escalation with a particular focus on swallowing outcomes. Patients are younger and, with the improved outcomes reported in the literature, surviving longer with the consequences of their treatment. Given the changing demographic of this patient group, there are a number of opportunities to optimize swallowing outcomes, and this should be underpinned by detailed swallowing evaluation and counselling prior to treatment. A number of strategies have been suggested to improve swallowing outcomes; however, persisting and late-onset swallowing effects continue to be a risk. Transoral surgery is evolving as an option for the treatment of HPV-positive disease; however, more studies are required to understand functional outcomes.
  
  
  CONCLUSIONS
  Clinical trials are now underway to ascertain the effectiveness of tailored treatments for HPV-positive OPC with a focus on swallowing outcomes. It is encouraging that studies are now including detailed, multidimensional swallowing evaluation. Until such time as longitudinal data are available, patients should be treated by speech-language pathologists based on existing radiation treatment protocols and in the knowledge that patients may experience significant late swallowing difficulties.
authors.affiliation: aDepartment of Speech, Language and Swallowing Disorders, Massachusetts General Hospital, Boston, Massachusetts, USA bSpeech and Language Therapy Department, The Royal Marsden NHS Foundation Trust, London, UK.
authors.forename: Tessa A
authors.initials: TA
authors.lastname: Goldsmith
authors.forename: Justin W G
authors.initials: JW
authors.lastname: Roe
mesh_terms: D059248:Chemoradiotherapy / Q000379:methods*; D003680:Deglutition Disorders / Q000628:therapy* / Q000821:virology*; D019468:Disease Management; D006801:Humans; D009959:Oropharyngeal Neoplasms / Q000628:therapy* / Q000821:virology*; D030361:Papillomavirus Infections / Q000150:complications*