title: T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children.
abstract: We determined the serum IgE levels and T-helper (Th)17-related cytokines during distinct hepatitis A virus (HAV)-induced clinical courses in children. A significantly higher concentration of macrophage inflammatory protein 3α, interleukin (IL)-17E and IL-17F in HAV-infected children with intermediate liver injury compared with those with minor liver damage was found. A reduction in the IgE levels in those patients who showed the highest levels of IL-17F in the group of intermediate liver injury was found. The data suggested that the Th17-related profile is associated with the severity of HAV infection and might play a role on the modulation achieved by HAV during allergies.
authors.affiliation: aff1.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Trujillo-Ochoa
authors.affiliation: aff1.
authors.forename: Karla F
authors.initials: KF
authors.lastname: Corral-Jara
authors.affiliation: aff4.
authors.forename: Griselda
authors.initials: G
authors.lastname: Escobedo-Meléndez
authors.affiliation: Departamento de Medicina Veterinaria, Centro Universitario de Ciencias Biológicas y Agropecuarias, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Realpe
authors.affiliation: aff1.
authors.forename: Arturo
authors.initials: A
authors.lastname: Panduro
authors.affiliation: aff4.
authors.forename: Sonia
authors.initials: S
authors.lastname: Roman
authors.affiliation: aff1.
authors.forename: Nora A
authors.initials: NA
authors.lastname: Fierro
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006506:Hepatitis A / Q000276:immunology*; D017957:Hepatitis A Virus, Human / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D020381:Interleukin-17 / Q000097:blood*; D008099:Liver / Q000201:enzymology; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism
chemical_list: D020381:Interleukin-17; D007073:Immunoglobulin E; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase