title: Normative data for macular volume with high-definition spectral-domain optical coherence tomography (Spectralis).
abstract: OBJECTIVE
  To establish normative data for macular volume by spectral-domain optical coherence tomography (SD-OCT) in subjects with no known retinal disease.
  
  
  METHODS
  In an academic institutional setting, 50 subjects (age range 20-84 years) with no known retinal disease, best-corrected visual acuity 20/20, and normal intraocular pressure were enrolled. The subjects were divided into 3 age groups: group 1 included subjects 20-40 years of age, group 2 included subjects 41-60 years of age, and group 3 included subjects 61 years of age and older. All subjects underwent a complete ophthalmologic examination and testing, if needed, to rule out any retinal diseases or glaucoma. Retinal volume (RV) in 9 Early Treatment Diabetic Retinopathy Study (ETDRS) subfields and total macular volume (TMV) inclusive of all 9 subfields were analyzed. Statistical analyses were carried out using analysis of variance.
  
  
  RESULTS
  Overall, the mean TMV ± SD for ETDRS circles with a diameter of 1, 2.22, and 3.45 mm was determined to be 3.04 ± 0.14 mm3. Among the ETDRS subfields, RV was highest in the nasal outer field, with a mean of 0.47 ± 0.02 mm3. The TMV did not show a significant difference with age (p = 0.17). However, TMV was significantly higher in males (p = 0.003) and in Caucasian and Asian subjects compared to African Americans (p = 0.017).
  
  
  CONCLUSIONS
  Normative values for total macular volume in ETDRS subfields in otherwise healthy eyes were measured to be 3.04 ± 0.14 mm3.
authors.affiliation: Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL - USA.
authors.forename: Ravi K
authors.initials: RK
authors.lastname: Murthy
authors.affiliation: Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL - USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Diaz
authors.affiliation: Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL - USA.
authors.forename: Kakarla V
authors.initials: KV
authors.lastname: Chalam
authors.affiliation: Department of Ophthalmology, College of Medicine, University of Florida, Jacksonville, FL - USA.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Grover
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008266:Macula Lutea / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult