title: An antibacterial ortho-quinone diterpenoid and its derivatives from Caryopteris mongolica.
abstract: To identify antibacterial components in traditional Mongolian medicinal plant Caryopteris mongolica, an ortho-quinone abietane caryopteron A (1) and three its derivatives caryopteron B-D (2-4) were isolated from the roots of the plant together with three known abietanes demethylcryptojaponol (5), 6α-hydroxydemethyl cryptojaponol (6), and 14-deoxycoleon U (7). The chemical structures of these abietane derivatives were elucidated on the basis of spectroscopic data. Compounds 1-4 had C-13 methylcyclopropane substructures, and 2-4 had a hexanedioic anhydride ring C instead of ortho-quinone in 1. The stereochemistry of these compound was assumed from NOE spectra and ECD Cotton effects. Compounds 1 and 5-7 showed antibacterial activities against the Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Micrococcus luteus, being 1 the more potent.
authors.affiliation: School of Engineering and Applied Sciences, National University of Mongolia, POB-617, Ulaanbaatar-46A, Mongolia.
authors.forename: Erdenebileg
authors.initials: E
authors.lastname: Saruul
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan. Electronic address: murata-t@tohoku-pharm.ac.jp.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Murata
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan; Monos University, Sonsgolon's Road-Street 4/A, 20th Khoroo, Songinokhairkhan District, Ulaanbaatar, Mongolia.
authors.forename: Erdenechimeg
authors.initials: E
authors.lastname: Selenge
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan.
authors.forename: Kenroh
authors.initials: K
authors.lastname: Sasaki
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University, 4-1 Komatsushima 4-chome, Aoba-ku, Sendai 981-8558, Japan.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
authors.affiliation: School of Engineering and Applied Sciences, National University of Mongolia, POB-617, Ulaanbaatar-46A, Mongolia.
authors.forename: Javzan
authors.initials: J
authors.lastname: Batkhuu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D019686:Lamiaceae / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry / Q000378:metabolism; D011809:Quinones / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D011809:Quinones
keywords: Abietane diterpenoid; Caryopteris mongolica; Gram-positive bacteria; Methylcyclopropane; ortho-Quinone