title: Preclinical and clinical development of an anti-kappa free light chain mAb for multiple myeloma.
abstract: Monoclonal antibodies (mAb) have had tremendous success in treating a variety of cancers over the past twenty years. Yet despite their widespread clinical use, which includes treatments for haematological malignancies, there are still no approved mAb therapies for multiple myeloma (MM). This is likely to change within the next few years with a number of mAb therapies being assessed in late stage clinical trials, most notably, the anti-CS-1 mAb, elotuzumab, and the anti-CD38 mAb, daratumumab, which are currently being evaluated in Phase III clinical trials for MM. In this review, we will discuss the preclinical and clinical development of MDX-1097, a Phase II candidate which targets cell membrane-associated kappa immunoglobulin free light chains expressed on the surface of MM cells.
authors.affiliation: School of Life Sciences, Centre for Health Technologies, University of Technology Sydney, Ultimo, NSW 2007, Australia; Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA; Centre for Biomedical Research, Burnet Institute, Melbourne, VIC 3004, Australia. Electronic address: andrew.hutchinson@uts.edu.au.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Hutchinson
authors.affiliation: Cellmid Ltd, Sydney, NSW 2000, Australia.
authors.forename: Darren R
authors.initials: DR
authors.lastname: Jones
authors.affiliation: School of Life Sciences, Centre for Health Technologies, University of Technology Sydney, Ultimo, NSW 2007, Australia.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Raison
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000276:immunology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D007167:Immunotherapy / Q000379:methods*; D008958:Models, Molecular; D009101:Multiple Myeloma / Q000276:immunology / Q000378:metabolism / Q000628:therapy*; D011485:Protein Binding / Q000276:immunology; D017434:Protein Structure, Tertiary
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D007145:Immunoglobulin kappa-Chains; C000598984:MDX-1097
keywords: Free light chain; Immunotherapy; MDX-1097; Monoclonal antibody; Multiple myeloma