title: Reduced systemic levels of IL-10 are associated with the severity of obstructive sleep apnea and insulin resistance in morbidly obese humans.
abstract: Obstructive sleep apnea (OSA) has been related to elevation of inflammatory cytokines and development of insulin resistance in morbidly obese (MO) subjects. However, it is still unclear whether the systemic concentration of anti-inflammatory mediators is also affected in MO subjects directly related to the severity of OSA and level of insulin resistance. Normal weight and MO subjects were subjected to overnight polysomnography in order to establish the severity of OSA, according to the apnea-hypopnea index (AHI). Blood samples were obtained for estimation of total cholesterol and triglycerides, insulin, glucose, insulin resistance, tumor necrosis factor alpha (TNF-α), interleukin 12 (IL12), and interleukin 10 (IL-10). Serum levels of IL-10 were significantly lower in MO subjects with OSA than in MO and control individuals without OSA. Besides being inversely associated with serum TNF-α and IL-12, decreased IL-10 levels were significantly related to increased AHI, hyperinsulinemia, and insulin resistance. Serum IL-10 is significantly reduced in morbidly obese subjects with severe OSA while also showing a clear relationship with a state of hyperinsulinemia and insulin resistance probably regardless of obesity in the present sample. It may be of potential clinical interest to identify the stimulatory mechanisms of IL-10 in obese individuals with OSA.
authors.affiliation: Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Avenida de los Barrios 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, Mexico.
authors.forename: Sonia
authors.initials: S
authors.lastname: Leon-Cabrera
authors.affiliation: Departamento de Biología de la Reproducción y Clínica de Trastornos de Sueño, Universidad Autónoma Metropolitana-Iztapalapa, 09340 México, DF, Mexico.
authors.forename: Yoaly
authors.initials: Y
authors.lastname: Arana-Lechuga
authors.affiliation: Departamento de Biología de la Reproducción y Clínica de Trastornos de Sueño, Universidad Autónoma Metropolitana-Iztapalapa, 09340 México, DF, Mexico.
authors.forename: Enrique
authors.initials: E
authors.lastname: Esqueda-León
authors.affiliation: Departamento de Biología de la Reproducción y Clínica de Trastornos de Sueño, Universidad Autónoma Metropolitana-Iztapalapa, 09340 México, DF, Mexico.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Terán-Pérez
authors.affiliation: Servicio de Medicina Interna, Hospital General de México, 06726 México, DF, Mexico.
authors.forename: Antonio
authors.initials: A
authors.lastname: Gonzalez-Chavez
authors.affiliation: Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Hospital General de México, 06726 México, DF, Mexico.
authors.forename: Galileo
authors.identifier: 0000-0002-9224-7400
authors.initials: G
authors.lastname: Escobedo
authors.affiliation: Departamento de Biología de la Reproducción y Clínica de Trastornos de Sueño, Universidad Autónoma Metropolitana-Iztapalapa, 09340 México, DF, Mexico.
authors.forename: Javier
authors.initials: J
authors.lastname: Velázquez Moctezuma
mesh_terms: D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D006946:Hyperinsulinism; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D016753:Interleukin-10 / Q000097:blood* / Q000378:metabolism; D053765:Interleukin-12 Subunit p35 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000276:immunology* / Q000378:metabolism; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000378:metabolism; D020181:Sleep Apnea, Obstructive / Q000378:metabolism*; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D055815:Young Adult
chemical_list: D016207:Cytokines; C508609:IL10 protein, human; C508858:IL12A protein, human; D007328:Insulin; D053765:Interleukin-12 Subunit p35; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002784:Cholesterol