title: Rapid Osseointegration of Titanium Implant With Innovative Nanoporous Surface Modification: Animal Model and Clinical Trial.
abstract: OBJECTIVE
  SLAffinity is the hybrid topography consisting of micropits and nanoporous TiO2 layers through electrochemical oxidation to mimic the natural bony environment. The aim of this study was to examine the rate of osseointegration in animal models and to further investigate the stability for implants with SLAffinity-treated surface in the clinical trial.
  
  
  METHODS
  Implants were installed in the mandibular canine-premolar area of 12 miniature pigs. Each pig received 2 implants with the same shapes but with different chemical surfaces. In the clinical trial, 25 patients were included. Each patient received 1 SLAffinity-treated implant on the posterior area of either arch. Resonance frequency analysis and computed tomography were assessed weekly over the first 12 weeks after implant placement.
  
  
  RESULTS
  The results found that surface treatment did affect the bone-to-implant contact (BIC) significantly. Comparison of BIC at 3 weeks in animal study showed that the SLAffinity-treated implants presented significantly higher values than machine surface implants. SLAffinity-treated implants also proved clinically successful through 12 months, ready for prosthodontic restoration.
  
  
  CONCLUSIONS
  The effect of SLAffinity treatments enhanced osseointegration significantly, especially at early stages of bone healing. Clinical trial finding, furthermore, ensured that the SLAffinity treatment was a reliable surface modification alternative.
authors.affiliation: *Researcher, Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan; Director, Department of Dentistry, Taipei Medical University-Shuang-Ho Hospital, Taipei, Taiwan. †Director, Department of Dentistry, Lo-Hsu Foundation Inc., Lotung Poh-Ai Hospital, Yilan, Taiwan. ‡Chairman, Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, Taiwan; Chairman, Graduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taipei, Taiwan; Dean, Collage of Oral Medicine, Taipei Medical University, Taipei, Taiwan. §Researcher, Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan; Researcher, Research Center for Biomedical Implants and Microsurgery Devices, Taipei Medical University, Taipei, Taiwan; Researcher, Graduate Institute of Biomedical Materials and Engineering, Taipei Medical University, Taipei, Taiwan. ‖Director, Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei, Taiwan; Lecturer, School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Mao-Suan
authors.initials: MS
authors.lastname: Huang
authors.forename: Li-Kai
authors.initials: LK
authors.lastname: Chen
authors.forename: Keng-Liang
authors.initials: KL
authors.lastname: Ou
authors.forename: Han-Yi
authors.initials: HY
authors.lastname: Cheng
authors.forename: Che-Shun
authors.initials: CS
authors.lastname: Wang
mesh_terms: D000328:Adult; D000818:Animals; D001672:Biocompatible Materials; D015519:Bone Density; D003758:Dental Implantation, Endosseous / Q000295:instrumentation* / Q000379:methods*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D020007:Implants, Experimental; D008297:Male; D016348:Osseointegration / Q000502:physiology*; D013499:Surface Properties; D013552:Swine; D013556:Swine, Miniature; D014025:Titanium; D014057:Tomography, X-Ray Computed
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants; C009495:titanium dioxide; D014025:Titanium