title: Diagnostic procedures for autoimmune vesiculobullous diseases: A review.
abstract: Oral soft tissues are affected by numerous pathologic conditions of variable etiology and hence their appropriate management relies on their accurate diagnosis. Clinical identification of intact vesicle and bulla in the oral cavity is really a challenge due to the regular irritation and the friable nature of oral mucosa. Rupture of these lesions leads to erosions or ulcerations on the surface, hence making the diagnosis of vesiculobullous (VB) lesions is even more difficult due to the fact that the differential diagnosis along with VB lesions will also include ulcerative, immunological-mediated diseases, and neoplasms and systemic diseases. Hence, knowledge of the clinical presentation of these disorders and the relevant diagnostic procedures is important not just for dermatologists, but also for general practitioners and dentists. In this article, the various procedures have been explained that can be used for the diagnostic purpose of VB lesions.
authors.affiliation: Department of Oral Pathology, Kalka Dental College and Hospital, Meerut, Uttar Pradesh, India.
authors.forename: Varun
authors.initials: V
authors.lastname: Rastogi
authors.affiliation: Department of Oral Pathology, Seema Dental College and Hospital, Rishikesh, Uttarakhand, India.
authors.forename: Rachna
authors.initials: R
authors.lastname: Sharma
authors.affiliation: Department of Oral Medicine & Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
authors.forename: Satya Ranjan
authors.initials: SR
authors.lastname: Misra
authors.affiliation: Department of Oral Pathology, Kalka Dental College and Hospital, Meerut, Uttar Pradesh, India.
authors.forename: Lalita
authors.initials: L
authors.lastname: Yadav
keywords: Bulla; Vesiculobullous; enzyme-linked immunosorbent assay; immunofluorescence; mucocutaneous; salt split; vesicle