title: Calibrated automated thrombography for monitoring coagulation function in patients with intracerebral haemorrhage.
abstract: OBJECTIVE
  To monitor coagulation function in patients with intracerebral haemorrhage (ICH) using calibrated automated thrombography.
  
  
  METHODS
  Patients admitted to hospital with ICH (confirmed within 18 h of symptom onset) were enrolled. Patient history and blood samples were obtained within 6 h of admission; further blood samples were collected on days 4, 8 and 15 (or on discharge between days 9-15: grouped with day 15 data). Blood samples were also collected from age- and sex-matched healthy controls. All samples underwent calibrated automated thrombography.
  
  
  RESULTS
  At admission, thrombin lag time and time to peak was longer, and endogenous thrombin potential and peak height were lower, in patients with ICH (n = 20) than in healthy controls (n = 29). Lag time in patients with ICH gradually decreased, but remained significantly longer than in controls until day 8. Time to peak also gradually decreased, but remained longer in patients than in controls by day 15. Endogenous thrombin potential and peak height gradually increased in patients, but remained lower than in controls on day 15.
  
  
  CONCLUSIONS
  Patients with ICH have poorer coagulation function than healthy individuals, but this function gradually recovers during hospitalization.
authors.affiliation: Department of Neurology, Peking University People's Hospital, Beijing, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Medical Laboratory, Peking University Jishuitan Hospital, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Neurology, Mancheng County Hospital, Baoding, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.affiliation: Medical Laboratory, Peking University People's Hospital, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Mancheng County Hospital, Baoding, China.
authors.forename: Chunpeng
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Peking University People's Hospital, Beijing, China gxg56@tom.com.
authors.forename: Xuguang
authors.initials: X
authors.lastname: Gao
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000188:drug therapy; D004487:Edema / Q000473:pathology; D001330:Electronic Data Processing; D015942:Factor VIIa / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011516:Prothrombin / Q000378:metabolism; D011517:Prothrombin Time; D011994:Recombinant Proteins / Q000627:therapeutic use; D013916:Thrombelastography; D013917:Thrombin / Q000378:metabolism; D013918:Thrombin Time
chemical_list: D011994:Recombinant Proteins; D011516:Prothrombin; C103587:recombinant FVIIa; D015942:Factor VIIa; D013917:Thrombin
keywords: Intracerebral haemorrhage; calibrated automated thrombogram; thrombin