title: Acute renal failure, systemic lupus erythematosus and thrombotic microangiopathy following treatment with beta-interferon for multiple sclerosis: case report and review of the literature.
abstract: We report a man with type 1 diabetes mellitus, autoimmune hypothyroidism and a tentative diagnosis of multiple sclerosis. Following treatment with beta interferon, he developed systemic lupus erythematosus with pericarditis, pleural effusions, cerebral infarction associated with anti-phospholipid antibody and acute renal failure due to thrombotic microangiopathy. He responded well to immunosuppression and anticoagulation. These complications may represent the most severe autoimmune reaction to beta interferon reported to date.
authors.affiliation: Renal Unit.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hansen
authors.affiliation: Renal Unit.
authors.forename: David
authors.initials: D
authors.lastname: New
authors.affiliation: Department of Pathology , Salford Royal NHS Foundation Trust , Salford, Greater Manchester.
authors.forename: Roy
authors.initials: R
authors.lastname: Reeve
authors.affiliation: Renal Unit.
authors.forename: Rosemary
authors.initials: R
authors.lastname: Donne
authors.affiliation: Department of Internal Medicine , Trafford Healthcare NHS Trust , UK.
authors.forename: William
authors.initials: W
authors.lastname: Stephens
keywords: acute renal failure; anti-phospholipid syndrome; beta-interferon; multiple sclerosis; systemic lupus erythematosus