title: Mycobacterial Growth.
abstract: In this work, we review progress made in understanding the molecular underpinnings of growth and division in mycobacteria, concentrating on work published since the last comprehensive review ( Hett and Rubin 2008). We have focused on exciting work making use of new time-lapse imaging technologies coupled with reporter-gene fusions and antimicrobial treatment to generate insights into how mycobacteria grow and divide in a heterogeneous manner. We try to reconcile the different observations reported, providing a model of how they might fit together. We also review the topic of mycobacterial spores, which has generated considerable discussion during the last few years. Resuscitation promoting factors, and regulation of growth and division, have also been actively researched, and we summarize progress in these areas.
authors.affiliation: Department of Medicine, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, SW7 2AZ, United Kingdom.
authors.forename: Iria
authors.initials: I
authors.lastname: Uhía
authors.affiliation: Department of Medicine, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, SW7 2AZ, United Kingdom.
authors.forename: Kerstin J
authors.initials: KJ
authors.lastname: Williams
authors.affiliation: Department of Mathematics, Imperial College London, London, SW7 2AZ, United Kingdom.
authors.forename: Vahid
authors.initials: V
authors.lastname: Shahrezaei
authors.affiliation: Department of Medicine, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, SW7 2AZ, United Kingdom.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Robertson
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D049108:Cell Enlargement / Q000187:drug effects; D002876:Chromosomes, Bacterial / Q000235:genetics / Q000502:physiology; D003952:Diagnostic Imaging / Q000379:methods; D024881:Drug Resistance, Bacterial / Q000187:drug effects / Q000502:physiology; D009161:Mycobacterium / Q000187:drug effects / Q000254:growth & development*; D013171:Spores, Bacterial / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins