title: Irisin, an exercise-induced myokine as a metabolic regulator: an updated narrative review.
abstract: Irisin, as a new hormone-like myokine, is discovered in the presence of exercise-induced peroxisome proliferator-activated receptor gamma coactivator-1-alpha (PGC-1α). Which substance plays an important role in energy metabolism in each organ in the body and the regulation of metabolic diseases such as obesity and diabetes. The finding of irisin can contribute to the exploration of the novel and effective therapeutic targets or therapeutic strategies of these metabolic diseases or metabolism-associated health issues. To date, little is known regarding the functions and regulatory mechanisms of irisin with respect to metabolic diseases or metabolism-associated health issues. In this narrative review article, we systematically introduce its structural characteristics, production and distribution in tissues and organs, and the regulation and corresponding mechanisms for metabolic diseases or metabolism-associated health issues of irisin. Meanwhile, its future prospects and the development of irisin-related products for the promotion of human health have also been proposed, which will benefit future research and application of irisin. Copyright © 2015 John Wiley & Sons, Ltd.
authors.affiliation: College of Health Science, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, Wuhan Sports University, Wuhan, China.
authors.forename: Ning
authors.identifier: http://orcid.org/0000-0002-8191-6744
authors.initials: N
authors.lastname: Chen
authors.affiliation: Graduate School, Wuhan Sports University, Wuhan, China.|College of Sports Science and Technology, Wuhan Sports University, Wuhan, China.
authors.forename: Qingxue
authors.initials: Q
authors.lastname: Li
authors.affiliation: College of Health Science, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, Wuhan Sports University, Wuhan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Health Science, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, Wuhan Sports University, Wuhan, China.
authors.forename: Shaohui
authors.initials: S
authors.lastname: Jia
mesh_terms: D052437:Adipocytes, Brown / Q000166:cytology / Q000378:metabolism; D052438:Adipocytes, White / Q000166:cytology / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002454:Cell Differentiation; D003071:Cognition; D004734:Energy Metabolism; D015444:Exercise; D005353:Fibronectins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000378:metabolism / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010805:Physical Conditioning, Animal; D015854:Up-Regulation
chemical_list: C577593:FNDC5 protein, human; D005353:Fibronectins
keywords: diabetes; exercise; irisin; metabolic disease; myokine; obesity