title: Effects of ethanol extract of Salvia hydrangea on hepatic and renal functions of streptozotocin-induced diabetic rats.
abstract: OBJECTIVE
  A wide range of liver and kidney disorders are associated with diabetes and there is a mutual relationship between diabetes and these diseases. Herbal medicine with having abundant ingredients is one of these options. The goal of this study was to compare the effects of alcoholic extract of aerial parts of S alvia hydrangea with glibenclamide on functional tests of liver and kidney in diabetic rats induced by streptozotocin.
  
  
  METHODS
  In this study, 35 male Wistar rats were divided into five groups (n= 7 in each group): control, diabetic control, and three experimental diabetic groups. The controls had normal access to water and food, the diabetic control group was given drug solvent and the three experimental groups received ethanol extract of Salvia hydrangea at doses of 100 and 200 mg and glibenclamideat a dose of 10 mg/kg/BW by gavage, respectively. To induce diabetes, a single dose of streptozotocin (60 mg/kg/BW) was injected to rats intraperitoneally. Blood samples were collected at day 21 from all groups and the related blood factors were measured and analyzed.
  
  
  RESULTS
  The results showed that the levels of creatinine, urea, aspartate aminotransferase (AST), and fasting blood sugar (FBS) in all diabetic groups increased compared to the control group. In all experimental groups and the group which received glibenclamide,a significant decrease was shown compared to the diabetic group (p<0.05).
  
  
  CONCLUSIONS
  The consumption of alcoholic extract of aerial parts of Salvia hydrangea may have beneficial effects on the reduction of diabetic complications by lowering blood sugar without any adverse effects on the kidney and liver tissue.
authors.affiliation: Department of Biology, Damghan Branch, Islamic Azad University, Semnan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Zarei
authors.affiliation: Department of Biology, Damghan Branch, Islamic Azad University, Semnan, Iran.
authors.forename: Gholamhassan
authors.initials: G
authors.lastname: Vaezi
authors.affiliation: Department of Biology, Payame Noor University,Tehran, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Malekirad
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
keywords: Diabetes; Glibenclamide; Kidney; Liver; Salvia hydrangea; Streptozotocin