title: The search for antifungals from Amazonian trees: a bio-inspired screening.
abstract: The anti-fungal activity of 60 extracts from 15 tree species in the French Guiana rainforest against human and wood-rotting fungi was studied. In this way (+)-mopanol (1) was isolated from the ethyl acetate extract of Peltogyne sp. (Caesalpiniaceae) wood. This work demonstrated that (1) the natural durability of wood can indeed guide the search for antifungal agents, (2) that extracts selected in this bio-inspired process exhibit a broad spectrum of antifungal activity and (3) that the method allows for the isolation of strongly active antifungals.
authors.forename: Charlie
authors.initials: C
authors.lastname: Basseta
authors.forename: Véronique
authors.initials: V
authors.lastname: Eparvier
authors.forename: Laila S
authors.initials: LS
authors.lastname: Espindolab
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D065947:Rainforest; D014197:Trees / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D010936:Plant Extracts; C000598935:mopanol