title: Synthesis of uranyl(II), vanadyl(II) and zirconyl urate complexes, spectral, thermal and biological studies.
abstract: Three urate chelations were obtained when uric acid was reacted with UO2(CH3COO)2H2O, VOSO4·XH2O and ZrOCl2·XH2O salts with neutralized with 0.1 M NaOH aqueous media. The 1:2 metal-to-ligand complexes [(UO2)2(C5H2N4O3)2](H2O), [(ZrO)2(H2O)2(C5H2N4O3)2] and [VO((C5H3N4O3)2] were characterized by elemental analyses, molar conductivity, (infrared, Raman and UV-vis) spectra, effective magnetic moment in Bohr magnetons, and thermal analysis (TG/DTG). The urate ligand coordinates as mononegative bidentate donor towards the mononuclear central vanadium atom and coordinated as binegative tetradentate mode towards the binuclear dioxouranium and zirconyl centers. The antibacterial activity of the metal complexes were tested against some kind of bacteria and fungi strains and compared with uric acid. The ligand, ZrO(II) and UO2(II) complex showed a week potential degradation on calf thymus DNA, whereas VO(II) complex slightly degraded the DNA.
authors.affiliation: Department of Chemistry, Faculty of Science, Taif University, Taif 888, Saudi Arabia; Department of Chemistry, Faculty of Science, Zagazig University, Egypt.
authors.forename: Samy M
authors.initials: SM
authors.lastname: El-Megharbel
authors.affiliation: Department of Chemistry, Faculty of Science, Mansoura University, Egypt; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia.
authors.forename: Nashwa M
authors.initials: NM
authors.lastname: El-Metwaly
authors.affiliation: Department of Chemistry, Faculty of Science, Taif University, Taif 888, Saudi Arabia; Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt. Electronic address: msrefat@yahoo.com.
authors.forename: Moamen S
authors.initials: MS
authors.lastname: Refat
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002417:Cattle; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D013059:Spectrum Analysis, Raman; D014501:Uranium / Q000737:chemistry* / Q000494:pharmacology; D014527:Uric Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014638:Vanadates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015040:Zirconium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D014527:Uric Acid; D014638:Vanadates; D014501:Uranium; D004247:DNA; C427203:calf thymus DNA; D015040:Zirconium
keywords: Biological activity; Raman; Thermal; Urate complexes