title: A new cytotoxic cytochalasin from the endophytic fungus Trichoderma harzianum.
abstract: The new natural product 4]-hydroxy-deacetyl-18-deoxycytochalasin H (1), together with the known deacetyl-18-deoxycytochalasin H (2) and 18-deoxycytochalasin H (3) were obtained from the endophytic fungus Trichoderma harzianum isolated from leaves of Cola nitida. The structure of the new compound was unambiguously determined by 1D and 2D NMR spectroscopy, and by HRESIMS measurements, as well as by comparison with the literature. Compounds 1-3 showed potent cytotoxic activity against the murine lymphoma (L5178Y) cell line and against human ovarian cancer (A2780 sens and A2780 CisR) cell lines (IC50 0.19-6.97 µM). The A2780 cell lines included cisplatin-sensitive (sens) and -resistant (R) cells.
authors.forename: Huiqin
authors.initials: H
authors.lastname: Chen
authors.forename: Georgios
authors.initials: G
authors.lastname: Daletos
authors.forename: Festus
authors.initials: F
authors.lastname: Okoye
authors.forename: Daowan
authors.initials: D
authors.lastname: Lai
authors.forename: Haofu
authors.initials: H
authors.lastname: Dai
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003572:Cytochalasins / Q000737:chemistry* / Q000494:pharmacology*; D008223:Lymphoma / Q000188:drug therapy; D051379:Mice; D015394:Molecular Structure; D014242:Trichoderma / Q000737:chemistry*
chemical_list: C000598622:4'-hydroxy-deacetyl-18-deoxycytochalasin H; D000970:Antineoplastic Agents; D003572:Cytochalasins