title: MiR-34a inhibits oral cancer progression partially by repression of interleukin-6-receptor.
abstract: Previous reports revealed that a significant decrease of miR-34a in oral cancer. But the role of miR-34a in oral cancer needs further research. In the present study, we will investigate the effect of miR-34a on oral cancer cell phenotypes. First, it was verified that miR-34a expression was lower in oral cancer tissues compared with their normal controls, so did the oral cancer cells. Next, it was showed that miR-34a overexpression in oral cancer cells could inhibit cell proliferation, G1 phase arrest, metastasis and epithelial mesenchymal transition. It was predicted that interleukin-6-receptor (IL6R) was a potential target gene of miR-34a by bioinformatics analysis and identified by luciferase assay. It was further showed that miR-34a inhibited oral cancer progression via IL6R. Collectively, our findings suggested that miR-34a may function as a tumor suppressor in oral cancer by targeting IL6R.
authors.affiliation: Department of Oral Medicine, School of Stomatology Xuzhou Medical College Xuzhou, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Oral and Maxillofacial Surgery, Collage of Stomatology, Guangxi Medical University Nanning, China.
authors.forename: Lichu
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Oral and Maxillofacial Surgery, Collage of Stomatology, Guangxi Medical University Nanning, China.
authors.forename: Dongshuang
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Oral and Maxillofacial Surgery, Collage of Stomatology, Guangxi Medical University Nanning, China.
authors.forename: Shuting
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Oral Medicine, School of Stomatology Xuzhou Medical College Xuzhou, China ; Department of Oral and Maxillofacial Surgery, School of Stomatology Xuzhou Medical College, and Department of Stomatology, The Affiliated Hospital of Xuzhou Medical College Xuzhou, China.
authors.forename: Jinhu
authors.initials: J
authors.lastname: Sun
mesh_terms: D059447:Cell Cycle Checkpoints / Q000235:genetics; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009062:Mouth Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D009362:Neoplasm Metastasis / Q000235:genetics* / Q000473:pathology; D019947:Receptors, Interleukin-6 / Q000235:genetics* / Q000378:metabolism
chemical_list: C522425:MIRN34 microRNA, human; D035683:MicroRNAs; D019947:Receptors, Interleukin-6; C113250:interleukin-6 receptor alpha
keywords: IL6R; miR-34a; oral cancer