title: G-arylated hydrogen-bonded cyclic tetramer assemblies with remarkable thermodynamic and kinetic stability.
abstract: The preparation and self-assembly of novel G-C dinucleoside monomers that are equipped with electron-poor aryl groups at the G-N(2) amino group have been studied. Such monomers associate via Watson-Crick H-bonding into discrete unstrained tetrameric macrocycles that arise as a thermodynamically and kinetically stabilized product in a wide variety of experimental conditions, including very polar solvent environments and low concentrations. G-arylation produces an increased stability of the cyclic assembly, as a result of a subtle interplay between enthalpic and entropic effects involving the solvent coordination sphere.
authors.affiliation: Nanostructured Molecular Systems and Materials Group, Departamento de Química Orgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors.forename: Sonia
authors.initials: S
authors.lastname: Romero-Pérez
authors.affiliation: Nanostructured Molecular Systems and Materials Group, Departamento de Química Orgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Camacho-García
authors.affiliation: Nanostructured Molecular Systems and Materials Group, Departamento de Química Orgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Montoro-García
authors.affiliation: Nanostructured Molecular Systems and Materials Group, Departamento de Química Orgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors.forename: Ana M
authors.initials: AM
authors.lastname: López-Pérez
authors.affiliation: Nanostructured Molecular Systems and Materials Group, Departamento de Química Orgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Sanz
authors.affiliation: Nanostructured Molecular Systems and Materials Group, Departamento de Química Orgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Mayoral
authors.affiliation: Nanostructured Molecular Systems and Materials Group, Departamento de Química Orgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
authors.forename: David
authors.initials: D
authors.lastname: González-Rodríguez