title: Cerebral white matter volume changes in patients with obsessive-compulsive disorder: Voxel-based morphometry.
abstract: OBJECTIVE
  We carried out a voxel-based morphometry (VBM) study to evaluate cerebral white matter (WM) volume alteration in obsessive-compulsive disorder (OCD) and its correlation with the scores of the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS).
  
  
  METHODS
  Fourteen patients with OCD, who were diagnosed using the DSM-IV-TR, and 14 age-matched healthy controls participated. The high-resolution magnetic resonance imaging data were analyzed by voxel-based morphometry and Statistical Parametric Mapping 8.
  
  
  RESULTS
  There was no significant difference in the total intracranial volumes between OCD patients and healthy controls. However, patients with OCD showed significantly increased WM volumes in the right dorsolateral prefrontal cortex, middle frontal gyrus, precuneus, and inferior parietal lobule compared with healthy controls. In addition, the OCD patients showed a positive correlation between the WM volumes of the dorsolateral prefrontal cortex and Y-BOCS scores (r = 0.334, P = 0.03 and Pearson's correlation coefficient = 0.58) rating for the severity of OCD symptoms.
  
  
  CONCLUSIONS
  WM volume variations of the specific brain regions in patients with OCD will be helpful to understand the neural connectivity associated with a symptom of OCD. Furthermore, the findings would be valuable to aid the diagnostic accuracy of OCD in connection with morphometric magnetic resonance imaging analysis.
authors.affiliation: Interdisciplinary Program of Biomedical Engineering, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: Shin-Eui
authors.initials: SE
authors.lastname: Park
authors.affiliation: Interdisciplinary Program of Biomedical Engineering, Chonnam National University, Gwangju, Republic of Korea.|Department of Radiology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Republic of Korea.
authors.forename: Gwang-Woo
authors.initials: GW
authors.lastname: Jeong
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D059906:Neuroimaging; D009771:Obsessive-Compulsive Disorder / Q000473:pathology*; D066127:White Matter / Q000473:pathology*; D055815:Young Adult
keywords: Yale-Brown Obsessive-Compulsive Scale; dorsolateral prefrontal cortex; obsessive-compulsive disorder; voxel-based morphometry; white matter volume change