title: Damage-Associated Molecular Patterns in the Course of Lung Cancer--A Review.
abstract: More than 20 years ago, the 'danger theory' was proposed which explains why potent immune responses with no microbial components are elicited against tissue transplants, injuries, tumours and autoimmune diseases. It states that the immune system can distinguish between dangerous and innocuous endogenous signals. In response to trauma or other types of tissue and cell damage, certain molecules that function inside the cell are released or secreted from damaged or dying cells. Such mechanisms initiate an immune response in the absence of infection. These immunostimulatory molecules were named damage-associated molecular patterns (DAMPs). In this article, we will review the available data on the influence of select DAMPs on lung cancer cells and tumour microenvironments. We will also summarize the current information regarding the interactions between lung cancer-associated DAMPs and their toll-like receptors.
authors.affiliation: Department of Immunology, Chair of Clinical Immunology, University of Medical Sciences, Poznań, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Łagiedo
authors.affiliation: Department of Immunology, Chair of Clinical Immunology, University of Medical Sciences, Poznań, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Sikora
authors.affiliation: Department of Immunology, Chair of Clinical Immunology, University of Medical Sciences, Poznań, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Kaczmarek
mesh_terms: D005966:Glucuronidase / Q000378:metabolism; D024243:HMGB1 Protein / Q000235:genetics; D006360:Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D037662:Pulmonary Surfactant-Associated Protein A / Q000096:biosynthesis; D009418:S100 Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology*; D059016:Tumor Microenvironment / Q000276:immunology; D000099175:Heparanase
chemical_list: D005966:Glucuronidase; D024243:HMGB1 Protein; D006360:Heat-Shock Proteins; D037662:Pulmonary Surfactant-Associated Protein A; D009418:S100 Proteins; D051193:Toll-Like Receptors; D000099175:Heparanase; C585491:HMGB1 protein, human