title: Correlating Parkinson's disease motor symptoms with three-dimensional [(18)F]FP-CIT PET.
abstract: OBJECTIVE
  To investigate the correlation between the striatal three-dimensional location and the Unified Parkinson's Disease Rating Scale (UPDRS) motor score in the context of idiopathic Parkinson's disease (PD) through radiolabeled N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane positron emission tomography/computed tomography (FP-CIT PET/CT).
  
  
  METHODS
  In this cross-sectional study, we assessed the UPDRS motor score and performed FP-CIT PET/CT in patients with PD. Thirty-eight patients with idiopathic PD [average 70 years of age (range 49-86); male:female ratio 12:26] were enrolled. The correlation between FP-CIT PET/CT and the UPDRS III scores was investigated after the transformation of PET images by an alternative method using MATLAB.
  
  
  RESULTS
  Left caudate nucleus uptake negatively correlated with UPDRS items 18, 20 (face), 22 (right arm and leg), 23, 24 (right side), 26 (right side), 27, 30, and 31, while right caudate nucleus uptake positively correlated with items 18, 22 (left arm), 26, and 29. Putamen uptake correlated with items 22 and 25. Left caudate nucleus uptake positively correlated with axial and akinetic-rigidity symptoms.
  
  
  CONCLUSIONS
  FP-CIT uptake in specific basal ganglia structures strongly correlated with the UPDRS III motor score. Among these, the left caudate nucleus exhibited the strongest relationship with axial and akinetic-rigidity PD symptoms.
authors.affiliation: Department of Neurosurgery, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, South Korea.
authors.forename: Moonyoung
authors.initials: M
authors.lastname: Chung
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, 410 SungBong-Ro, Heungdeok-gu, Cheongju-Si, 361-763, Korea. youngseokparkmd@gmail.com.
authors.forename: Young Seok
authors.initials: YS
authors.lastname: Park
authors.affiliation: Department of Neurosurgery, Chungbuk National University Hospital, Chungbuk National University, College of Medicine, 410 SungBong-Ro, Heungdeok-gu, Cheongju-Si, 361-763, Korea.
authors.forename: Ji Seon
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Department of Neurology, Hallym Medical Center, Hallym University College of Medicine, Chuncheon, South Korea.
authors.forename: Yun Joong
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Neurology, Hallym Medical Center, Hallym University College of Medicine, Chuncheon, South Korea.
authors.forename: Hyeo Il
authors.initials: HI
authors.lastname: Ma
authors.affiliation: Department of Nuclear Medicine, CHA University School of Medicine, Seongnam, Korea.
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Jang
authors.affiliation: Department of Neurosurgery, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, South Korea.
authors.forename: Ryoong
authors.initials: R
authors.lastname: Huh
authors.affiliation: Department of Neurology Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Neurology Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.
authors.forename: Won-Chan
authors.initials: WC
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology*; D064847:Multimodal Imaging; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D049268:Positron-Emission Tomography; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014326:Tropanes
chemical_list: D014326:Tropanes; D019788:Fluorodeoxyglucose F18; C087552:2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
keywords: Iodine-123 fluoropropyl–carbomethoxy-3β-(4-iodophenyl) nortropane; PET; Parkinson’s disease; Three-dimensional analysis; UPDRS