title: Hypokalemia and rhabdomyolysis.
abstract: The adverse drug event manager of the Capital Region of Denmark received a report of a 65-year-old male with type II diabetes and long-lasting treatment with indapamide. In addition, he had a history of a high consumption of licorice. For 2 weeks, the patient suffered from myalgia, which the general practitioner suspected to be polymyalgia rheumatica and referred him to the hospital. Initial blood samples revealed a reduced potassium concentration of 1.5 mmol/L (reference value: 6.6-4.6 mmol/L) and an elevated creatine kinase of 18,400 IU/L (reference value: 40-280 IU/L). We believe that the patient developed rhabdomyolysis due to severe hypokalemia, possibly induced by a pharmacodynamic interaction between licorice and indapamide.
authors.affiliation: Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Denmark.
authors.forename: Henrik
authors.initials: H
authors.lastname: Horwitz
authors.affiliation: Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Denmark.
authors.forename: Vidar A
authors.initials: VA
authors.lastname: Woeien
authors.affiliation: Department of Internal Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark.
authors.forename: Linda Wiuff
authors.initials: LW
authors.lastname: Petersen
authors.affiliation: Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Denmark.
authors.forename: Espen
authors.initials: E
authors.lastname: Jimenez-Solem
keywords: Hypokalemia; indapamide; licorice; rhabdomyolysis; side-effects