title: Differences in Regional Brain Volumes Two Months and One Year after Mild Traumatic Brain Injury.
abstract: Conventional structural imaging is often normal after mild traumatic brain injury (mTBI). There is a need for structural neuroimaging biomarkers that facilitate detection of milder injuries, allow recovery trajectory monitoring, and identify those at risk for poor functional outcome and disability. We present a novel approach to quantifying volumes of candidate brain regions at risk for injury. Compared to controls, patients with mTBI had significantly smaller volumes in several regions including the caudate, putamen, and thalamus when assessed 2 months after injury. These differences persisted but were reduced in magnitude 1 year after injury, suggesting the possibility of normalization over time in the affected regions. More pronounced differences, however, were found in the amygdala and hippocampus, suggesting the possibility of regionally specific responses to injury.
authors.affiliation: 1 Philips Research North America , Briarcliff Manor, New York.|2 Thayer School of Engineering, Dartmouth College , Hanover, New Hampshire.
authors.forename: Lyubomir
authors.initials: L
authors.lastname: Zagorchev
authors.affiliation: 3 Digital Imaging, Philips Research Hamburg , Hamburg, Germany .
authors.forename: Carsten
authors.initials: C
authors.lastname: Meyer
authors.affiliation: 3 Digital Imaging, Philips Research Hamburg , Hamburg, Germany .
authors.forename: Thomas
authors.initials: T
authors.lastname: Stehle
authors.affiliation: 3 Digital Imaging, Philips Research Hamburg , Hamburg, Germany .
authors.forename: Fabian
authors.initials: F
authors.lastname: Wenzel
authors.affiliation: 3 Digital Imaging, Philips Research Hamburg , Hamburg, Germany .
authors.forename: Stewart
authors.initials: S
authors.lastname: Young
authors.affiliation: 3 Digital Imaging, Philips Research Hamburg , Hamburg, Germany .
authors.forename: Jochen
authors.initials: J
authors.lastname: Peters
authors.affiliation: 3 Digital Imaging, Philips Research Hamburg , Hamburg, Germany .
authors.forename: Juergen
authors.initials: J
authors.lastname: Weese
authors.affiliation: 2 Thayer School of Engineering, Dartmouth College , Hanover, New Hampshire.
authors.forename: Keith
authors.initials: K
authors.lastname: Paulsen
authors.affiliation: 4 Geisel School of Medicine, Dartmouth College , Hanover, New Hampshire.
authors.forename: Matthew
authors.initials: M
authors.lastname: Garlinghouse
authors.affiliation: 4 Geisel School of Medicine, Dartmouth College , Hanover, New Hampshire.
authors.forename: James
authors.initials: J
authors.lastname: Ford
authors.affiliation: 4 Geisel School of Medicine, Dartmouth College , Hanover, New Hampshire.
authors.forename: Robert
authors.initials: R
authors.lastname: Roth
authors.affiliation: 4 Geisel School of Medicine, Dartmouth College , Hanover, New Hampshire.
authors.forename: Laura
authors.initials: L
authors.lastname: Flashman
authors.affiliation: 4 Geisel School of Medicine, Dartmouth College , Hanover, New Hampshire.
authors.forename: Thomas
authors.initials: T
authors.lastname: McAllister
mesh_terms: D000328:Adult; D000679:Amygdala / Q000098:blood supply*; D001930:Brain Injuries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000098:blood supply*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017072:Neostriatum / Q000098:blood supply*; D012039:Regional Blood Flow / Q000502:physiology*; D013788:Thalamus / Q000098:blood supply*; D013997:Time Factors
keywords: MRI; mild traumatic brain injury; subcortical structures; volume