title: Construction of a model for predicting creatinine clearance in Japanese patients treated with Cisplatin therapy.
abstract: OBJECTIVE
  There exist various useful predictive models, such as the Cockcroft-Gault model, for estimating creatinine clearance (CLcr). However, the prediction of renal function is difficult in patients with cancer treated with cisplatin. Therefore, we attempted to construct a new model for predicting CLcr in such patients.
  
  
  METHODS
  Japanese patients with head and neck cancer who had received cisplatin-based chemotherapy were used as subjects. A multiple regression equation was constructed as a model for predicting CLcr values based on background and laboratory data.
  
  
  RESULTS
  A model for predicting CLcr, which included body surface area, serum creatinine and albumin, was constructed. The model exhibited good performance prior to cisplatin therapy. In addition, it performed better than previously reported models after cisplatin therapy.
  
  
  CONCLUSIONS
  The predictive model constructed in the present study displayed excellent potential and was useful for estimating the renal function of patients treated with cisplatin therapy.
authors.affiliation: Department of Pharmacy Practice and Science I, School of Pharmacy, Kitasato University, Shirogane, Minato, Tokyo, Japan Department of Clinical Pharmaceutics, Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo, Japan.
authors.forename: Airi
authors.initials: A
authors.lastname: Yajima
authors.affiliation: Department of Clinical Pharmaceutics, Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo, Japan uesawa@mypharm.ac.jp.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Uesawa
authors.affiliation: Pharmaceutical Department, National Hospital Organization Tokyo Medical Center, Higashigaoka, Meguro, Tokyo, Japan.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Ogawa
authors.affiliation: Pharmaceutical Department, National Hospital Organization Tokyo Medical Center, Higashigaoka, Meguro, Tokyo, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Yatabe
authors.affiliation: Pharmaceutical Department, National Hospital Organization Tokyo Medical Center, Higashigaoka, Meguro, Tokyo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kondo
authors.affiliation: Pharmaceutical Department, National Cancer Center Hospital East, Kashinoha, Kashiwa, Chiba, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Saito
authors.affiliation: Pharmaceutical Department, National Hospital Organization Tokyo Medical Center, Higashigaoka, Meguro, Tokyo, Japan.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Suzuki
authors.affiliation: Department of Pharmacy Practice and Science I, School of Pharmacy, Kitasato University, Shirogane, Minato, Tokyo, Japan Department of Pharmacy, Kitasato University Hospital, Kitasato, Minami, Sagamihara, Kanagawa, Japan.
authors.forename: Kouichiro
authors.initials: K
authors.lastname: Atsuda
authors.affiliation: Department of Clinical Pharmaceutics, Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Kagaya
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002945:Cisplatin / Q000008:administration & dosage; D003404:Creatinine / Q000378:metabolism*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012709:Serum Albumin
chemical_list: D012709:Serum Albumin; D003404:Creatinine; D002945:Cisplatin
keywords: Head and neck cancer; cisplatin; creatinine clearance; renal function; serum albumin