title: Successful treatment of a patient with severe atopic dermatitis and severe asthma by centrifugal therapeutic plasma exchange.
abstract: This is a case of a 42-year-old atopic man with severe atopic dermatitis and asthma who despite long-term immunosuppression was not well controlled. He had a very high IgE at 7897 Iu/mL prior to treatment. He underwent two therapeutic plasma exchanges (TPEs) through two peripheral lines in our outpatient department, which led to an absolute decrease of 44.1% and 37% in his plasma IgE for each exchange, and immediate sustained improvement in shortness of breath, and atopic dermatitis, and hence led to a vast improvement in his quality of life. TPE offers a new exciting adjunctive treatment option for severe atopic individuals, where it may provide a novel role to reduce health burden and improve clinical symptoms. Further studies need to be performed to establish an optimal protocol and potential maintenance with recently available targeted anti-IgE biologics.
authors.affiliation: Department of Dermatology, Barts Health NHS Trust, London, UK Department of Dermatology, Broomfield Hospital, Essex, UK.
authors.forename: Louise
authors.initials: L
authors.lastname: Fuller
authors.affiliation: Terumo BCT, Zaventum, Belgium.
authors.forename: Benit
authors.initials: B
authors.lastname: Maru
authors.affiliation: Terumo BCT, Zaventum, Belgium.
authors.forename: Neil
authors.initials: N
authors.lastname: Isserlis
authors.affiliation: Department of Dermatology, Barts Health NHS Trust, London, UK.
authors.forename: Rino
authors.initials: R
authors.lastname: Cerio
mesh_terms: D000328:Adult; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D003876:Dermatitis, Atopic / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D010951:Plasma Exchange; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D007073:Immunoglobulin E