title: CD317 is over-expressed in B-cell chronic lymphocytic leukemia, but not B-cell acute lymphoblastic leukemia.
abstract: CD317 was first identified as a multiple myeloma-associated antigen. Here we report the expression of CD317 in normal B cells and B-cell malignancies. In normal bone marrow, CD317 demonstrates a biphasic expression pattern, with higher expression on stage 1 and stage 3 hematogones, but not on stage 2 hematogones. CD317 is over-expressed in B-cell chronic lymphocytic leukemia, and appears associated with negative CD38 expression. Moreover, CD317 is barely detectable in B-cell acute lymphoblastic leukemia. Our results suggest that CD317 expression might be of prognostic significance for B-CLL, and CD317 could be used as a new marker for minimal residual disease detection in B-ALL.
authors.affiliation: Department of Pathology, University Hospitals Case Medical Center, Case Western Reserve University Cleveland 44106, Ohio, USA ; Department of Pathology and Laboratory Medicine, University of Pennsylvania Philadelphia 19104, PA, USA.
authors.forename: Shunyou
authors.initials: S
authors.lastname: Gong
authors.affiliation: Department of Pathology, University Hospitals Case Medical Center, Case Western Reserve University Cleveland 44106, Ohio, USA.
authors.forename: Ebenezer S
authors.initials: ES
authors.lastname: Osei
authors.affiliation: Department of Pathology, University Hospitals Case Medical Center, Case Western Reserve University Cleveland 44106, Ohio, USA.
authors.forename: David
authors.initials: D
authors.lastname: Kaplan
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Pennsylvania Philadelphia 19104, PA, USA.
authors.forename: Youhai H
authors.initials: YH
authors.lastname: Chen
authors.affiliation: Department of Pathology, University Hospitals Case Medical Center, Case Western Reserve University Cleveland 44106, Ohio, USA.
authors.forename: Howard
authors.initials: H
authors.lastname: Meyerson
mesh_terms: D000208:Acute Disease; D015703:Antigens, CD / Q000032:analysis / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D058851:GPI-Linked Proteins / Q000032:analysis / Q000096:biosynthesis; D006801:Humans; D007223:Infant; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*; D000074010:Bone Marrow Stromal Antigen 2
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2
keywords: B lymphocytes; CD317; acute lymphoblastic leukemia; chronic lymphocytic leukemia