title: [Neurosensory, aesthetic and dental late effects of childhood cancer therapy].
abstract: Oncologic management in pediatric patient may be associated with a high risk of neurosensory deficit, such as taste, olfaction, vision and hearing. These neurosensory deficits can be linked to chemotherapy toxicity or to a direct deleterious effect of local radiotherapy or surgical management in case of craniofacial cancers. Neurosensory deficit may be temporary but are usually irreversible and frequently progress after the completion of treatment. Taste and olfaction deficits expose to high risk of nutritional complications and quality of life alteration. Hyposialia, as a result of irradiation of the salivary glands, increases taste changes and the risk of dental caries. The risk of cataract is present in patients who received high dose corticosteroids and/or brain or orbital irradiation. When hearing is affected, a risk of impaired intellectual or academic performance is increased with an impact on the quality of life in absence of specific care. Finally, there are some cosmetic consequences of therapy such as alopecia and scarring that alter the image of the patient. Early detection of these problems in order to limit medical, psychological, educational and social impact is mandatory. Moreover, high risk of worsening of these deficits after completion of therapy support long-term follow-up children treated for cancer, especially with head and neck primary.
authors.affiliation: Centre hospitalier universitaire de Saint-Étienne, service d'hématologie et d'oncologie pédiatrique, avenue Albert-Raimond, 42055 Saint-Étienne cedex, France. Electronic address: sandrine.thouvenin@chu-st-etienne.fr.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Thouvenin-Doulet
authors.affiliation: Centre hospitalier universitaire de Lille, service d'ORL et de chirurgie cervico-faciale pédiatrique, 59000 Lille, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Fayoux
authors.affiliation: Centre hospitalier universitaire de Lille, service d'ORL et de chirurgie cervico-faciale pédiatrique, 59000 Lille, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Broucqsault
authors.affiliation: Institut de cancérologie Lorraine - Alexis-Vautrin, service de radiothérapie, 54000 Nancy, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Bernier-Chastagner
mesh_terms: D000505:Alopecia / Q000209:etiology; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006311:Hearing Disorders / Q000209:etiology; D006801:Humans; D000857:Olfaction Disorders / Q000209:etiology; D010859:Pigmentation Disorders / Q000209:etiology; D011183:Postoperative Complications; D011832:Radiation Injuries / Q000150:complications*; D012678:Sensation Disorders / Q000209:etiology*; D013651:Taste Disorders / Q000209:etiology; D013705:Temporomandibular Joint Disorders / Q000209:etiology; D014076:Tooth Diseases / Q000209:etiology*; D014786:Vision Disorders / Q000209:etiology; D014987:Xerostomia / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents
keywords: Audition; Cancer; Children; Enfant; Esthétique; Goût; Hearing loss; Odorat; Smell disturbance; Séquelles; Vision; Vision impairment