title: Erlotinib as an alternative treatment for NSCLC. Case Report.
abstract: BACKGROUND
  Erlotinib is an approved treatment for NSCLC locally advanced or with metastases, after failure of initial chemotherapy. The authors present a NSCLC clinical case of great clinical and imaging improvement, with no drug-induced toxicity observed, after treatment with erlotinib.
  
  
  METHODS
  A 76-year-old woman, never-smoker, had been diagnosed for lung adenocarcinoma, through thoracoscopy, after presenting a large-volume pleural effusion. At the time of diagnosis it was inoperable (stage IIIB - T4 N1 M0). She was submitted to two consecutive chemotherapy treatments with carboplatin+gemcitabin and pemetrexed, respectively. Due to its failure, with lack of response, erlotinib was set as the alternative choice, with great clinical and imaging improvement after 6 months of treatment.
  
  
  CONCLUSIONS
  The authors recommend, even in the absence of EGFR result, the use of erlotinib when progression of the disease is seen, after initial chemotherapy, especially in lung adenocarcinoma and in never-smokers. Rev Port Pneumol 2008; XIV (Supl 3): S61-S63.
authors.affiliation: Serviço de Pneumologia, Hospital de S. Marcos, Braga.
authors.forename: Rui
authors.initials: R
authors.lastname: Rolo
authors.affiliation: Serviço de Pneumologia, Hospital de S. Marcos, Braga.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Iglésias
authors.affiliation: Serviço de Pneumologia, Hospital de S. Marcos, Braga.
authors.forename: Lurdes
authors.initials: L
authors.lastname: Ferreira
authors.affiliation: Serviço de Pneumologia, Hospital de S. Marcos, Braga.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Fernandes
authors.affiliation: Serviço de Pneumologia, Hospital de S. Marcos, Braga.
authors.forename: Manuel
authors.initials: M
authors.lastname: Macedo
authors.affiliation: Serviço de Pneumologia, Hospital de S. Marcos, Braga.
authors.forename: João
authors.initials: J
authors.lastname: Cunha
keywords: Erlotinib; cancro pulmão; chemotherapy; lung cancer; quimioterapia