title: Prognostic significance and anti-proliferation effect of microRNA-365 in hepatocellular carcinoma.
abstract: MircroRNA functions as tumor suppressor or promoter in hepatocellular carcinoma (HCC). Researchers have found that miR-365 expression was lower in HCC tissues compared with that in adjacent normal tissues. However, its prognostic significance and anti-proliferation effect in HCC remain to be clarified. In this study, we firstly found that miR-365 expression was lower in HCC tissues compared with that in adjacent normal tissues. Then, we analyzed miR-365 expression level and its clinicopathological and prognostic significance. Finally, overexpression of miR-365 inhibits HCC cell proliferation and migration in vitro. Our findings suggest that miR-365 expression was an independent poor prognostic factor for HCC patient overall survival and suppressed tumor cell growth. Therefore, miR-365 may serve as a valuable prognostic marker and promising target for HCC.
authors.affiliation: Transplantation Center of The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Zhizhao
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Transplantation Center of The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Zufa
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Transplantation Center of The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Qifa
authors.initials: Q
authors.lastname: Ye
authors.affiliation: Transplantation Center of The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Yingzi
authors.initials: Y
authors.lastname: Ming
authors.affiliation: Transplantation Center of The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Transplantation Center of The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Transplantation Center of The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Lian
authors.initials: L
authors.lastname: Liu
authors.affiliation: Transplantation Center of The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Transplantation Center of The Third Xiangya Hospital of Central South University Changsha 410013, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Cheng
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D060888:Real-Time Polymerase Chain Reaction; D014162:Transfection
chemical_list: C546819:MIRN365 microRNA, human; D035683:MicroRNAs
keywords: hepatocellular carcinoma; miR-365; prognosis; proliferation