title: BubR1 kinase: protection against aneuploidy and premature aging.
abstract: The multidomain protein kinase BubR1 is a central component of the mitotic spindle assembly checkpoint (SAC), an essential self-monitoring system of the eukaryotic cell cycle that ensures the high fidelity of chromosome segregation by delaying the onset of anaphase until all chromosomes are properly bi-oriented on the mitotic spindle. We discuss the roles of BubR1 in the SAC and the implications of BubR1-mediated interactions that protect against aneuploidy. We also describe the emerging roles of BubR1 in cellular processes that extend beyond the SAC, discuss how mice models have revealed unanticipated functions for BubR1 in the regulation of normal aging, and the potential role of BubR1 as therapeutic target for the development of innovative anticancer therapies.
authors.affiliation: Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK.
authors.forename: Maria
authors.initials: M
authors.lastname: Kapanidou
authors.affiliation: Center for Biomedical Informatics, Harvard Medical School, Harvard University. 10 Shattuck Street, Boston, MA 02115, USA.
authors.forename: Semin
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford OX3 0BP, UK. Electronic address: vbolanos-garcia@brookes.ac.uk.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Bolanos-Garcia
mesh_terms: D019588:Aging, Premature / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D000782:Aneuploidy; D000818:Animals; D042822:Genomic Instability; D006801:Humans; D059566:M Phase Cell Cycle Checkpoints; D008958:Models, Molecular; D058990:Molecular Targeted Therapy; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: C584277:BUB1 protein, human; D017346:Protein Serine-Threonine Kinases
keywords: BubR1; chromosome segregation; genome instability; kinetochore; premature aging; spindle assembly checkpoint (SAC)