title: Comparison of Immunogenicity Between Inactivated and Live Attenuated Hepatitis A Vaccines Among Young Adults: A 3-Year Follow-up Study.
abstract: A randomized clinical trial of hepatitis A vaccines (1 or 2 doses of inactivated vaccine [Healive] or 1 dose of live attenuated vaccine [Biovac]) was conducted among adults to evaluate seroprotection rates and geometric mean concentrations of antibody against hepatitis A virus for 36 months. High rates of seroprotection persisted for at least 36 months among adults who received 1 or 2 doses of inactivated hepatitis A vaccine but not among adults who received 1 dose of live attenuated hepatitis A vaccine. The long-term serial monitoring of immunogenicity induced by 1 dose of inactivated hepatitis A vaccine is needed to determine an effective alternative to a 2-dose schedule.
  
  
  BACKGROUND
  NCT01865968.
authors.affiliation: Department of Microbiology and Center of Infectious Disease, School of Basic Medical Sciences, Peking University Health Science Center, Beijing.
authors.forename: Xue-en
authors.initials: XE
authors.lastname: Liu
authors.affiliation: Nanchang Center for Disease Control and Prevention, Jiangxi.
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Chen
authors.affiliation: Nanchang Center for Disease Control and Prevention, Jiangxi.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liao
authors.affiliation: Nanchang Center for Disease Control and Prevention, Jiangxi.
authors.forename: Yisheng
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Nanchang Center for Disease Control and Prevention, Jiangxi.
authors.forename: Hairong
authors.initials: H
authors.lastname: Wen
authors.affiliation: Nanchang Center for Disease Control and Prevention, Jiangxi.
authors.forename: Shihui
authors.initials: S
authors.lastname: Peng
authors.affiliation: Sinovac Biotech, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Microbiology and Center of Infectious Disease, School of Basic Medical Sciences, Peking University Health Science Center, Beijing.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Microbiology and Center of Infectious Disease, School of Basic Medical Sciences, Peking University Health Science Center, Beijing.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Microbiology and Center of Infectious Disease, School of Basic Medical Sciences, Peking University Health Science Center, Beijing.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhuang
mesh_terms: D000293:Adolescent; D002681:China; D005260:Female; D005500:Follow-Up Studies; D006506:Hepatitis A / Q000276:immunology / Q000517:prevention & control*; D035922:Hepatitis A Antibodies / Q000097:blood*; D022362:Hepatitis A Vaccines / Q000276:immunology*; D030041:Hepatitis A virus / Q000276:immunology*; D006801:Humans; D008297:Male; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology; D055815:Young Adult
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated
keywords: immunogenicity; inactivated hepatitis A vaccine; live attenuated hepatitis A vaccine