title: [Effect-of Angong Niuhuang Pill on Th1/Th2 of cerebral infarction patients of phlegm-heat obstructing orifices in China and Indonesia].
abstract: OBJECTIVE
  To observe the effect of Angong Niuhuang Pill (ANP) on Thl/Th2 in cerebral infarction patients and to explore the mechanism of phlegm-heat obstructing orifices.
  
  
  METHODS
  Re- cruited were 30 cerebral infarction patients of phlegm-heat obstructing orifices syndrome (PHOOS) both in China and Indonesia. They were assigned to 4 groups according to the use of ANP, the Chinese treatment group, the Indonesia treatment group, the Chinese control group, and the Indonesia control group. Patients in the two control groups received conventional treatment, while those in the two treatment group additionally took ANP for 30 successive days. Their adverse reactions were observe, and levels of INF-γ and IL-4 were detected.
  
  
  RESULTS
  The INF-γ level and the INF-γ/IL-4 ratio significantly decreased, and the IL-4 level increased after treatment in the four groups with statistical difference (P < 0.05). Compared with the control group after treatment in the same country, the INF-γ level and the INF-γ/IL-4 ratio were lower, and the IL-4 level was higher in the two treatment groups (P < 0.05). Compared with the two Chinese groups, the INF-γ level and the INF-γ/IL-4 ratio were higher, and the IL-4 level was lower in the two Indonesian groups (P < 0.05). There was no statistical difference in the post-treatment indices between the two treatment groups.
  
  
  CONCLUSIONS
  ANP had moderating effect on Th1/Th2 in cerebral infarction pa- tients. Cerebral infarction patients of PHOOS might exist certain relation with Th1/Th2.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Ma
authors.forename: Chun-Xiang
authors.initials: CX
authors.lastname: Zhou
mesh_terms: D001688:Biological Products; D002544:Cerebral Infarction / Q000188:drug therapy*; D002681:China; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006358:Hot Temperature; D006801:Humans; D007214:Indonesia; D007371:Interferon-gamma / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism
chemical_list: D001688:Biological Products; D004365:Drugs, Chinese Herbal; D015847:Interleukin-4; C570000:niuhuang; D007371:Interferon-gamma