title: Equine herpesvirus type 1 tegument protein VP22 is not essential for pathogenicity in a hamster model, but is required for efficient viral growth in cultured cells.
abstract: VP22 is a major tegument protein of Equine herpesvirus type 1 (EHV-1) that is a conserved protein among alphaherpesviruses. However, the roles of VP22 differ among each virus, and the roles of EHV-1 VP22 are still unclear. Here, we constructed an EHV-1 VP22 deletion mutant and a revertant virus to clarify the role of VP22. We found that EHV-1 VP22 was required for efficient viral growth in cultured cells, but not for virulence in a hamster model.
authors.affiliation: Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Ayaka
authors.initials: A
authors.lastname: Okada
authors.forename: Satoko
authors.initials: S
authors.lastname: Izume
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohya
authors.forename: Hideto
authors.initials: H
authors.lastname: Fukushi
mesh_terms: D000818:Animals; D001835:Body Weight; D002417:Cattle; D002460:Cell Line; D006224:Cricetinae; D015967:Gene Expression Regulation, Viral / Q000502:physiology*; D006566:Herpesviridae Infections / Q000821:virology*; D004861:Herpesvirus 1, Equid / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D008297:Male; D009154:Mutation; D013047:Specific Pathogen-Free Organisms; D015678:Viral Structural Proteins / Q000235:genetics / Q000378:metabolism*; D014774:Virulence; D014776:Virus Cultivation
chemical_list: D015678:Viral Structural Proteins; C073413:herpes simplex virus type 1 protein VP22