title: Quetiapine-associated leucopenia and thrombocytopenia: a case report.
abstract: BACKGROUND
  There have been few reports regarding quetiapine-associated hematological effects other than white-blood-cell alteration. We present the first reported Han-Chinese case that developed leucopenia and thrombocytopenia after taking quetiapine.
  
  
  METHODS
  We present a case of a person with a bipolar I disorder who experienced leucopenia and thrombocytopenia after taking 400 mg/day of quetiapine and 1000 mg/day of valproic acid for three and one-half months. The hematological toxicity abated upon the discontinuation of both drugs. However, due to the intolerable side effects of the replaced antipsychotic (haloperidol), and according to the patient's preference, we prescribed quetiapine and valproic acid again. There was a recurrence of leucopenia and a decreased platelet count by the sixth day. The adverse effects disappeared soon after we discontinued quetiapine, while keeping valproic acid treatment.
  
  
  CONCLUSIONS
  Quetiapine-associated leucopenia and thrombocytopenia seems reversible but possibly fatal. Therefore, clinical practitioners should be aware of this adverse reaction.
authors.affiliation: Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, 309, Song-De Road, Taipei, Taiwan. das54@tpech.gov.tw.
authors.forename: Kuang-Yuan
authors.initials: KY
authors.lastname: Fan
authors.affiliation: Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, 309, Song-De Road, Taipei, Taiwan. wenyin19@gmail.com.
authors.forename: Wen-Yin
authors.initials: WY
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, 309, Song-De Road, Taipei, Taiwan. mch@tpech.gov.tw.|Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan. mch@tpech.gov.tw.
authors.forename: Ming-Chyi
authors.initials: MC
authors.lastname: Huang
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D003987:Dibenzothiazepines / Q000009:adverse effects*; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced*; D008297:Male; D000069348:Quetiapine Fumarate; D013921:Thrombocytopenia / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate