title: Computer-simulated biopsy marking system for endoscopic surveillance of gastric lesions: a pilot study.
abstract: Endoscopic tattoo with India ink injection for surveillance of premalignant gastric lesions is technically cumbersome and may not be durable. The aim of the study is to evaluate the accuracy of a novel, computer-simulated biopsy marking system (CSBMS) developed for the endoscopic marking of gastric lesions. Twenty-five patients with history of gastric intestinal metaplasia received both CSBMS-guided marking and India ink injection in five points in the stomach at index endoscopy. A second endoscopy was performed at three months. Primary outcome was accuracy of CSBMS (distance between CSBMS probe-guided site and tattoo site measured by CSBMS). The mean accuracy of CSBMS at angularis was 5.3 ± 2.2 mm, antral lesser curvature 5.7 ± 1.4 mm, antral greater curvature 6.1 ± 1.1 mm, antral anterior wall 6.9 ± 1.6 mm, and antral posterior wall 6.9 ± 1.6 mm. CSBMS (2.3 ± 0.9 versus 12.5 ± 4.6 seconds; P = 0.02) required less procedure time compared to endoscopic tattooing. No adverse events were encountered. CSBMS accurately identified previously marked gastric sites by endoscopic tattooing within 1 cm on follow-up endoscopy.
authors.affiliation: Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China.
authors.forename: Weiling
authors.initials: W
authors.lastname: Hu
authors.affiliation: College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China ; Key Laboratory of Biomedical Engineering, Ministry of Education, Zhejiang University, Hangzhou 310027, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China.
authors.forename: Leimin
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China.
authors.forename: Shujie
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China.
authors.forename: Liangjing
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China.
authors.forename: Kan
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China.
authors.forename: Jiaguo
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; Division of Gastroenterology, Loma Linda University, Loma Linda, CA 92354, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Kim
authors.affiliation: College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China ; Key Laboratory of Biomedical Engineering, Ministry of Education, Zhejiang University, Hangzhou 310027, China.
authors.forename: Jiquan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Dai
authors.affiliation: College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China ; Key Laboratory of Biomedical Engineering, Ministry of Education, Zhejiang University, Hangzhou 310027, China.
authors.forename: Huilong
authors.initials: H
authors.lastname: Duan
authors.affiliation: Department of Gastroenterology Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou 310016, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Si
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002244:Carbon; D003199:Computer Systems; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology; D013653:Tattooing / Q000379:methods*
chemical_list: C028433:chinese ink; D002244:Carbon