title: Host-pathogen interaction during bacterial vaccination.
abstract: Vaccines have been developed and deployed against several important bacterial pathogens of humans, including Neisseria meningitidis, Bordetella pertussis, Streptococcus pneumoniae and Mycobacterium tuberculosis. These vaccines are generally considered a successful public health measure and are effective at controlling disease symptoms and/or burden. However, a troubling consequence of recent vaccination programs has been the selection of vaccine escape mutants, whereby the pathogen displays a different repertoire of immune targets than those represented in the vaccine formulation. To address these issues of antigenic variation and bacterial evolution, continued and sustained efforts in epidemiological surveillance, vaccine development/formulation research, and understanding of the host-pathogen interaction are required.
authors.affiliation: Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Queensland, Australia.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Barnett
authors.affiliation: Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Queensland, Australia.
authors.forename: Jin Yan
authors.initials: JY
authors.lastname: Lim
authors.affiliation: Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Queensland, Australia.
authors.forename: Amelia T
authors.initials: AT
authors.lastname: Soderholm
authors.affiliation: Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Queensland, Australia.
authors.forename: Tania
authors.initials: T
authors.lastname: Rivera-Hernandez
authors.affiliation: Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Queensland, Australia.
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: West
authors.affiliation: Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, Queensland, Australia. Electronic address: mark.walker@uq.edu.au.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Walker
mesh_terms: D000818:Animals; D000940:Antigenic Variation / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001419:Bacteria / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology / Q000517:prevention & control; D001428:Bacterial Vaccines / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D014611:Vaccination / Q000379:methods
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines