title: Abnormal karyotypes in osteochondroma: Case series and literature review.
abstract: BACKGROUND
  Osteochondroma is the most common benign bone tumor. However, there are infrequent studies karyotyping solitary osteochondromas.
  
  
  METHODS
  Retrospective review of the University of California, Los Angeles pathology database was performed for karyotype analyses (N = 522 specimens).
  
  
  RESULTS
  Two previously undescribed karyotypes were identified. First, was a karyotype showing paracentric inversion of chromosome 7. Second, was a karyotype showing monosomy 3, 6 and 13.
  
  
  CONCLUSIONS
  Abnormal karyotypes may be more frequently encountered in osteochondroma than previously understood. However, the clinical significance of these abnormalities are yet unknown.
authors.affiliation: Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Aaron W
authors.initials: AW
authors.lastname: James
authors.affiliation: Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Tirado
authors.affiliation: Department of Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Levine
authors.affiliation: Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Dry
keywords: Cartilage neoplasm; EXT1; Exostosis; Karyotype; Osteochondroma