title: Dopaminergic Dynamics Contributing to Social Behavior.
abstract: Social interaction is a complex behavior that is essential for the survival of many species, and it is impaired in a broad range of neuropsychiatric disorders. Several cortical and subcortical brain regions have been implicated in a variety of sociosexual behaviors, with pharmacological studies pointing to a key role of the neurotransmitter dopamine. However, little is understood about the real-time circuit dynamics causally underlying social interaction. Here, we consider current knowledge on the role of brain reward circuitry in same-sex social behavior and describe findings from new methods for probing how this circuitry governs social motivation in health and disease.
authors.affiliation: The Gladstone Institutes, University of California, San Francisco, California 94158 deissero@stanford.edu lisa.gunaydin@gladstone.ucsf.edu.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Gunaydin
authors.affiliation: Departments of Bioengineering and Psychiatry, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305 deissero@stanford.edu lisa.gunaydin@gladstone.ucsf.edu.
authors.forename: Karl
authors.initials: K
authors.lastname: Deisseroth
mesh_terms: D001321:Autistic Disorder / Q000503:physiopathology; D003071:Cognition; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D009042:Motivation; D009415:Nerve Net / Q000503:physiopathology; D012919:Social Behavior
chemical_list: D004298:Dopamine