title: In vitro evaluation of the antibiofilm properties of chlorhexidine and delmopinol on dental implant surfaces.
abstract: Biofilm development on the internal surfaces of dental implants and dental implant components may be associated with peri-implant hard and soft tissue abnormalities. Currently, no protocols have been established for effective disinfection of removable implant components. The purpose of this study was to evaluate the antibiofilm properties of commonly used dental antimicrobial agents (chlorhexidine and delmopinol) on multispecies biofilms. Biofilms of 48 h and 168 h maturity were exposed to 0.2% chlorhexidine, 2% chlorhexidine and a product containing 0.2% delmopinol for 5, 10 and 20 min. 2% chlorhexidine was the most effective agent, achieving a total viable biofilm reduction ranging from 96.2% to >99.99% depending on the time of exposure and the stage of biofilm development.
authors.affiliation: Public Health England, PHL London, 3rd Floor Pathology & Pharmacy Building, 80 Newark Street, London E1 2ES, UK; Microbiology Unit, Eastman Dental Hospital, UCLH NHS Foundation Trust, 256 Gray's Inn Road, London WC1X 8LD, UK. Electronic address: derren.ready@phe.gov.uk.
authors.forename: Derren
authors.initials: D
authors.lastname: Ready
authors.affiliation: Department of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK.
authors.forename: Georgios
authors.initials: G
authors.lastname: Theodoridis
authors.affiliation: Microbiology Unit, Eastman Dental Hospital, UCLH NHS Foundation Trust, 256 Gray's Inn Road, London WC1X 8LD, UK; Department of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK.
authors.forename: Ingrid
authors.initials: I
authors.lastname: Green
authors.affiliation: Department of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK.
authors.forename: Lena
authors.initials: L
authors.lastname: Ciric
authors.affiliation: Department of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Pratten
authors.affiliation: Continuing Professional Development, UCL Eastman Dental Institute, 123 Gray's Inn Road, London WC1X 8WD, UK.
authors.forename: Weiming
authors.initials: W
authors.lastname: Tay
authors.affiliation: Department of Prosthodontics, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, UK.
authors.forename: Ailbhe
authors.initials: A
authors.lastname: McDonald
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology*; D015921:Dental Implants / Q000382:microbiology*; D004203:Disinfection / Q000379:methods*; D006801:Humans; D009025:Morpholines / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D015921:Dental Implants; D009025:Morpholines; C073738:delmopinol; D002710:Chlorhexidine
keywords: Antimicrobial susceptibility; Biofilm; Dental implant components; Disinfection