title: Choroid plexus separation in fetuses without ventriculomegaly: Natural course and postnatal outcome.
abstract: OBJECTIVE
  To evaluate fetuses with choroid plexus separation without ventriculomegaly in terms of fetal malformations, behavior of the separation during follow-up, and postnatal outcome.
  
  
  METHODS
  In total, 172 fetuses with choroid plexus separation without ventriculomegaly were included in this prospective study. Fetal sonography was performed at 2- to 4-week intervals, and detailed physical and neurologic examinations were performed after their delivery. Fetuses were categorized into normal and abnormal subgroups according to the outcome.
  
  
  RESULTS
  Sixteen fetuses (9.3%) were included in the abnormal-outcome group and 156 fetuses (90.7%) were included in the normal-outcome group. Both the initial mean lateral ventricular diameter (9.3 mm versus 8.6 mm) and the initial mean choroid plexus separation (4.8 mm versus 3.3 mm) were greater in the abnormal group than in the normal group (p < 0.001 for both comparisons). We found that 4.0 mm was the best cutoff point of choroid plexus separation to detect a major anomaly, with 87.5% sensitivity and 93.6% specificity.
  
  
  CONCLUSIONS
  Choroid plexus separation without ventriculomegaly often resolves within the third trimester and does not affect postnatal outcome. It can be associated with various fetal malformations; however, with a comprehensive examination, all fetal malformations can be detected prenatally. Follow-up sonography studies would be useful, especially in the case of suspected corpus callosum agenesis.
authors.affiliation: Ankara Atatürk Education and Research Hospital, Department of Radiology, Ankara, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ipek
authors.affiliation: Ankara Atatürk Education and Research Hospital, Department of Radiology, Ankara, Turkey.
authors.forename: Asli Tanrivermis
authors.initials: AT
authors.lastname: Sayit
authors.affiliation: Ankara Atatürk Education and Research Hospital, Department of Radiology, Ankara, Turkey.
authors.forename: Ilkay S
authors.initials: IS
authors.lastname: Idilman
authors.affiliation: Diskapi Yildirim Beyazit Education and Research Hospital, Department of Radiology, Ankara, Turkey.
authors.forename: Aydın
authors.initials: A
authors.lastname: Kurt
authors.affiliation: Ankara Atatürk Education and Research Hospital, Department of Radiology, Ankara, Turkey.
authors.forename: Nurdan
authors.initials: N
authors.lastname: Cay
authors.affiliation: Ankara Atatürk Education and Research Hospital, Department of Radiology, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Unal
authors.affiliation: Hacettepe University, Faculty of Medicine, Department of Biostatistics, Ankara, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Karabulut
authors.affiliation: Ankara Atatürk Education and Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey.
authors.forename: Huseyin Levent
authors.initials: HL
authors.lastname: Keskin
authors.affiliation: Ankara Atatürk Education and Research Hospital, Department of Radiology, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karaoglanoglu
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000000981:diagnostic imaging; D002552:Cerebral Ventricles / Q000000981:diagnostic imaging* / Q000196:embryology*; D002831:Choroid Plexus / Q000000981:diagnostic imaging* / Q000196:embryology*; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal
keywords: choroid plexus separation; fetal brain; fetal malformations; fetal ultrasonography; neurosonology; ultrasonography