title: Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria.
abstract: Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.
authors.affiliation: Department of Chemistry, University of Alberta, 11227 Saskatchewan Drive, Edmonton, Alberta T6E 2M9, Canada. john.vederas@ualberta.ca.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Cochrane
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Lohans
authors.forename: Marco J
authors.initials: MJ
authors.lastname: van Belkum
authors.forename: Manon A
authors.initials: MA
authors.lastname: Bels
authors.forename: John C
authors.initials: JC
authors.lastname: Vederas
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D056507:Paenibacillus / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification* / Q000494:pharmacology*; D011113:Polymyxins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; D011113:Polymyxins; C017770:tridecaptins