title: Expression of heat-shock protein gp96 in gallbladder cancer and its prognostic clinical significance.
abstract: OBJECTIVE
  To detect the expression and prognostic clinical significance of heat-shock protein gp96 (HSP gp96) in gallbladder cancer.
  
  
  METHODS
  Immunohistochemistry was used to detect and compare the rate of HSP gp96 expression in 107 samples of gallbladder cancer, 70 of gallbladder adenoma and 67 of chronic cholecystitis. The association of clinicopathological factors and patients' survival were calculated by univariate and multivariate (Cox proportional hazard regression method) analysis.
  
  
  RESULTS
  The expression positive rate of HSP gp96 was 90.7% (97/107) in gallbladder cancer, 71.4% (50/70) in gallbladder adenoma and 47.76% (32/67) in chronic cholecystitis respectively. The positive rate of HSP gp96 in gallbladder cancer tissues was significantly higher than that in gallbladder adenoma and chronic cholecystitis tissues (P < 0.01). Multivariate and Cox regression analysis showed that positive of HSP gp96 (P = 0.026) expression was an independent poor prognostic predictor in gallbladder cancer.
  
  
  CONCLUSIONS
  HSP gp96-positive expression is closely correlated with poor survival in gallbladder cancer.
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Xingtai Medical College Harbin, China ; Department of General Surgery, Second Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Chuanqi
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Shibo
authors.initials: S
authors.lastname: Sun
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Second Affiliated Hospital of Harbin Medical University Harbin, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000236:Adenoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002764:Cholecystitis / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D005260:Female; D005706:Gallbladder Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D006360:Heat-Shock Proteins
keywords: HSP gp96; chronic cholecystitis; gallbladder adenoma; gallbladder cancer