title: Atypical exanthems associated with Parvovirus B19 (B19V) infection in children and adults.
abstract: Parvovirus B19 (B19V) infection may differently manifest in various age groups. Erythema infectiosum ('fifth disease') is the most common B19V manifestations in children. Arthralgias and arthritis, with or without rash, are common manifestations of B19V infection in adults. Pruritus is usually present in adults and children. However, other cutaneous manifestations and atypical exanthems have been occasionally reported during B19V infection. To investigate the putative role of B19V infection in atypical exanthems, a total of 390 consecutive patients with atypical exanthems were analysed for B19V infection by determining B19V IgG and IgM antibodies titres in acute and convalescent phase as well as B19V DNA detection in serum by polymerase chain reaction (PCR). Atypical exanthems resulted related to B19V infection in 6 of the 120 pediatric (5%) and 14 of the 270 adult patients (5.2%). In conclusion this study reveals that atypical exanthems related to B19V infection are possible both in children and in adults, with a similar prevalence.
authors.affiliation: IRCCS A.O.U. San Martino-IST DISSAL, Department of Dermatology, Genoa, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Drago
authors.affiliation: IRCCS A.O.U. San Martino-IST DISSAL, Department of Dermatology, Genoa, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Ciccarese
authors.affiliation: Department of Health Sciences, University of Milano-Bicocca, Monza, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Broccolo
authors.affiliation: IRCCS A.O.U. San Martino-IST DISSAL, Department of Dermatology, Genoa, Italy.
authors.forename: Sanja
authors.initials: S
authors.lastname: Javor
authors.affiliation: IRCCS A.O.U. San Martino-IST DISSAL, Department of Dermatology, Genoa, Italy.
authors.forename: Aurora
authors.initials: A
authors.lastname: Parodi
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D004279:DNA, Viral / Q000097:blood; D016731:Erythema Infectiosum / Q000473:pathology* / Q000821:virology; D005076:Exanthema / Q000473:pathology* / Q000821:virology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
keywords: arthralgias; enanthem; exanthem; maculo-papular eruption; parvovirus B19; parvovirus B19 viremia; purpuric lesions