title: What Endothelial Cells from Patient iPSCs Can Tell Us about Aortic Valve Disease.
abstract: In a recent issue of Cell, Theodoris et al. (2015) used a complex systems biology approach to model vascular aortic calcification caused by mutations in the NOTCH1 gene. Comparison of endothelial cells from patient hiPSCs and genetically matched controls under fluid flow revealed novel mechanisms underlying the disease.
authors.affiliation: Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
authors.forename: Valeria V
authors.initials: VV
authors.lastname: Orlova
authors.affiliation: Department of Anatomy and Embryology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. Electronic address: c.l.mummery@lumc.nl.
authors.forename: Christine L
authors.initials: CL
authors.lastname: Mummery
mesh_terms: D044127:Epigenesis, Genetic; D005260:Female; D053263:Gene Regulatory Networks; D006801:Humans; D008297:Male; D051881:Receptor, Notch1 / Q000235:genetics*
chemical_list: D051881:Receptor, Notch1