title: The function and architecture of DEAH/RHA helicases.
abstract: Helicases are ubiquitous enzymes that participate in every aspect of nucleic acid metabolism. The DEAH/RHA family of helicases are involved in a variety of cellular processes including transcriptional and translational regulation, pre-mRNA splicing, pre-rRNA processing, mRNA export and decay, in addition to the innate immune response. Recently, the first crystal structures of a DEAH/RHA helicase unveiled the unique structural features of this helicase family. These structures furthermore illuminate the molecular mechanism of these proteins and provide a framework for analysis of their interaction with nucleic acids, regulatory proteins and large macromolecular complexes.
authors.forename: Yangzi
authors.initials: Y
authors.lastname: He
authors.forename: Gregers R
authors.initials: GR
authors.lastname: Andersen
authors.forename: Klaus H
authors.initials: KH
authors.lastname: Nielsen