title: Successful kidney transplantation with a well-matched donor despite a positive crossmatch; detection and management of sensitization secondary to an alternate allelic variant of 'self' HLA.
abstract: Under current UK standards of deceased donor typing, the formation by the recipient of HLA antibody against an allelic variant of a 'self' antigen creates a particular problem for organ allocation. In the reported case, the decision to transplant was taken in the situation of a positive flow crossmatch result attributed to allelic antibody. The potential that target antigen density contributed to this patient's subsequent good outcome is discussed.
authors.affiliation: Department of Transplant Immunology, St James's University Hospital, Leeds, UK.
authors.forename: Brendan
authors.initials: B
authors.lastname: Clark
authors.affiliation: Department of Transplant Immunology, St James's University Hospital, Leeds, UK.
authors.forename: Neil
authors.initials: N
authors.lastname: Marsden
authors.affiliation: Department of Transplant Immunology, St James's University Hospital, Leeds, UK.
authors.forename: Katherine
authors.initials: K
authors.lastname: McKinley
authors.affiliation: Department of Renal Medicine, St James's University Hospital, Leeds, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Lewington
authors.affiliation: Department of Renal Medicine, St James's University Hospital, Leeds, UK.
authors.forename: Chas
authors.initials: C
authors.lastname: Newstead
keywords: allelic; antibody; antigen; crossmatch