title: Self-poisoning in the acute care medicine 2005-2012.
abstract: OBJECTIVE
  To describe the trend of acute self-poisoning in the emergency and intensive care.
  
  
  METHODS
  Electronic charts of adults who presented to the emergency department of the University Hospital Leipzig with self-poisoning following a suicide attempt (suicide group), intoxication (intoxication group), drug overdose for relief of pain or discomfort (drug overdose group) between 2005 and 2012 were analyzed.
  
  
  RESULTS
  3533 adults (62.6% males) were identified, with the yearly admissions increasing from 305 in 2005 to 624 in 2012. The admission rate in relation to the total emergency department admissions also increased, from 1.2% in 2005 to 1.9% in 2012. 31.7% of the patients were younger than 25 years. The reasons for self-poisoning were suicide attempt (18.1%), intoxication (76.8%) and drug overdose (2.9%). The reason could not be clearly classified in 80 patients. Psychotropic drugs were used in 71.6% of suicide attempts, while alcohol was the sole cause of intoxication in 80.1% of cases in the intoxication group. Self-poisoning using at least two substances was observed in 52.0% of the suicide attempts, 10.3% of those with intoxication and 29.7% of those with drug overdose. While alcohol remains the most common cause of intoxication, there was a drastic increase in the consumption of cannabinoids, Crystal Meth and gamma-hydroxybutyrate in the years 2011 and 2012. ICU admission was necessary in 16.6% of the cases. There were 22 deaths (0.6% of the study population), of whom 15 were in the suicide group (2.3%), four (0.15%) in the intoxication group, and three in the not clearly classified group (3.8%).
  
  
  CONCLUSIONS
  Acute self-poisoning is an increasing medical issue. Psychotropic drugs remain the most common means of suicide attempt. Although alcohol intoxication is very frequent, intake of illicit drugs as the cause of emergency admission is increasing.
authors.affiliation: Medical Intensive Care Unit, University Hospital Leipzig, Liebigstr. 20, 04103, Leipzig, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Sorge
authors.forename: L
authors.initials: L
authors.lastname: Weidhase
authors.forename: M
authors.initials: M
authors.lastname: Bernhard
authors.forename: A
authors.initials: A
authors.lastname: Gries
authors.forename: S
authors.initials: S
authors.lastname: Petros
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002492:Central Nervous System Depressants / Q000506:poisoning; D003422:Critical Care; D062787:Drug Overdose / Q000453:epidemiology / Q000628:therapy; D004632:Emergency Medical Services; D000431:Ethanol / Q000506:poisoning; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D013287:Illicit Drugs / Q000506:poisoning; D008297:Male; D008875:Middle Aged; D011041:Poisoning / Q000453:epidemiology / Q000628:therapy*; D013405:Suicide / Q000706:statistics & numerical data; D013406:Suicide, Attempted; D055815:Young Adult
chemical_list: D002492:Central Nervous System Depressants; D013287:Illicit Drugs; D000431:Ethanol