title: Evaluation of the effects of a combination of Japanese honey and hydrocolloid dressing on cutaneous wound healing in male mice.
abstract: The aim of this study was to evaluate the effect of the combined use of Japanese honey and hydrocolloid dressing (HCD) on cutaneous wound healing. Mice were divided into four groups: the Acacia (Japan) + HCD, Manuka (New Zealand) + HCD, Chinese milk vetch (Japan) + HCD, and HCD (control) groups. The mice received two full-thickness wounds. The wounds of the HCD group were covered with HCD, whereas those of the other groups were treated with 0.1 mL of the relevant type of honey, before being covered with HCD. Wound area was significantly smaller in the HCD group than in the Acacia + HCD and Manuka + HCD groups on day 13 and days 8-14, respectively. Moreover, compared with the HCD group, reepithelialization was delayed in the Acacia + HCD group and reepithelialization and collagen deposition were delayed in the Chinese milk vetch + HCD and Manuka + HCD groups. These results indicate that the combined use of Japanese honey and HCD does not promote cutaneous wound healing compared with the use of HCD alone. Thus, this method is probably not useful for promoting healing.
authors.affiliation: Department of Clinical Nursing, Graduate Course of Nursing Science, Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Kanae
authors.identifier: 0000-0001-8876-4918
authors.initials: K
authors.lastname: Mukai
authors.affiliation: Department of Clinical Nursing, Graduate Course of Nursing Science, Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Koike
authors.affiliation: Department of Nursing, School of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Saki
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Nursing, School of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kawaguchi
authors.affiliation: Department of Nursing, School of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Fumika
authors.initials: F
authors.lastname: Katagiri
authors.affiliation: Department of Nursing, School of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Saki
authors.initials: S
authors.lastname: Nojiri
authors.affiliation: Department of Nursing, School of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamada
authors.affiliation: Department of Nursing, School of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Miyajima
authors.affiliation: Department of Nursing, School of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Matsumoto
authors.affiliation: Department of Clinical Nursing, Graduate Course of Nursing Science, Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Emi
authors.identifier: 0000-0002-4783-6601
authors.initials: E
authors.lastname: Komatsu
authors.affiliation: Department of Clinical Nursing, Graduate Course of Nursing Science, Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Yukari
authors.identifier: 0000-0002-6401-8678
authors.initials: Y
authors.lastname: Nakajima
authors.affiliation: Department of Clinical Nursing, Graduate Course of Nursing Science, Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Tamae
authors.initials: T
authors.lastname: Urai
authors.affiliation: School of Nursing, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku 920-0293, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Murakado
authors.affiliation: Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan.
authors.forename: Toshio
authors.identifier: 0000-0003-4949-5123
authors.initials: T
authors.lastname: Nakatani