title: Effect of Glycemic Regulation on Endocan Levels in Patients With Diabetes: A Preliminary Study.
abstract: Endothelial-specific molecule 1 (endocan) is expressed by endothelial cells and may have a major role in the regulation of cell adhesion and in the pathogenesis of inflammatory disorders. We aimed to assess change in endocan levels after 3 months of lifestyle change recommendations and guideline-based treatment. Diabetic patients (n = 77) who had neither chronic kidney disease nor chronic inflammatory disease were included. After baseline evaluation, the patients were advised lifestyle changes, and their medical treatment was determined individually according to recommendations of the American Diabetes Association (ADA) guidelines. At the end of third month patients were reevaluated. Baseline endocan levels were significantly increased in the study group compared with the control group. The third-month laboratory workup showed significant reductions in hemoglobin A1c, urinary albumin-to-creatinine ratio (UACR), and endocan levels. Only δ-UACR was independently correlated with δ-endocan in multivariate linear regression analysis. Our findings suggest that serum endocan concentrations are elevated in patients with type 2 diabetes and decrease following anti-hyperglycemic treatment. Furthermore, decrease in endocan concentrations might be associated with improved glycemic control and reductions in UACR.
authors.affiliation: Istanbul Okmeydani Education and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Yucel
authors.initials: Y
authors.lastname: Arman
authors.affiliation: Istanbul University Istanbul Medical Faculty, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Timur Selcuk
authors.initials: TS
authors.lastname: Akpinar
authors.affiliation: Istanbul University Istanbul Medical Faculty, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kose
authors.affiliation: Istanbul University Istanbul Medical Faculty, Department of Cardiology, Istanbul, Turkey samim03@hotmail.com.
authors.forename: Samim
authors.initials: S
authors.lastname: Emet
authors.affiliation: Istanbul Okmeydani Education and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Gulden
authors.initials: G
authors.lastname: Yuruyen
authors.affiliation: Istanbul Okmeydani Education and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Akarsu
authors.affiliation: Istanbul Okmeydani Education and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozcan
authors.affiliation: Istanbul University Istanbul Medical Faculty, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Ozan
authors.initials: O
authors.lastname: Yegit
authors.affiliation: Istanbul University Istanbul Medical Faculty, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Ramazan
authors.initials: R
authors.lastname: Cakmak
authors.affiliation: Istanbul Okmeydani Education and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Altun
authors.affiliation: Istanbul Okmeydani Education and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Sengul
authors.initials: S
authors.lastname: Aydin
authors.affiliation: Istanbul University Istanbul Medical Faculty, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Alpay
authors.initials: A
authors.lastname: Alibeyoğlu
authors.affiliation: Istanbul Okmeydani Education and Research Hospital, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Ugurlu
authors.affiliation: Istanbul University Istanbul Medical Faculty, Medical Student, Istanbul, Turkey.
authors.forename: Tugce
authors.initials: T
authors.lastname: Akcan
authors.affiliation: Istanbul University Istanbul Medical Faculty, Department of Internal Medicine, Istanbul, Turkey.
authors.forename: Tufan
authors.initials: T
authors.lastname: Tukek
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003131:Combined Modality Therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D003928:Diabetic Nephropathies / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D004032:Diet; D015536:Down-Regulation; D015444:Exercise; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000097:blood*; D016017:Odds Ratio; D011446:Prospective Studies; D011509:Proteoglycans / Q000097:blood*; D040242:Risk Reduction Behavior; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D009363:Neoplasm Proteins; D011509:Proteoglycans; C101134:ESM1 protein, human; C517652:hemoglobin A1c protein, human
keywords: endocan; fasting blood glucose; microalbuminuria; type 2 diabetes