title: Relationship of Interleukin-10 and Transforming Growth Factor-β Levels With Short-Term Graft Function After Kidney Transplantation.
abstract: BACKGROUND
  We evaluated the relationship of interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) levels with graft function in kidney transplantation patients receiving tacrolimus-based immunosuppression during the early post-transplantation period.
  
  
  METHODS
  There were 112 patients who underwent kidney transplantation from live donors between May 2011 and May 2013. Eight patients had at least 1 of the exclusion criteria, and the remaining 104 patients were included in the study. The recipients underwent evaluation for biochemical markers, complete blood count, and creatinine and cytokine (IL-10, TGF-β) levels during the pretransplantation and post-transplantation 6 months.
  
  
  RESULTS
  The creatinine level was negatively correlated with IL-10 and positively correlated with TGF-β levels in both the pretransplantation and early post-transplantation period.
  
  
  CONCLUSIONS
  Low serum TGF-β and high IL-10 levels at post-transplantation month 6 might have a positive effect on graft survival in living donor kidney recipients on tacrolimus-based immunosuppressive treatment.
authors.affiliation: Department of Nephrology, Tepecik Training and Research Hospital, Izmir, Turkey. Electronic address: bahadirh76@hotmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Colak
authors.affiliation: Department of Nephrology, Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Ersan
authors.affiliation: Department of Nephrology, Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Tanrisev
authors.affiliation: Tissue Typing Laboratory, Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Kurtulmus
authors.affiliation: Department of Allergy and Immunology, Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: P
authors.initials: P
authors.lastname: Degirmenci
authors.affiliation: Department of Allergy and Immunology, Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Comert
authors.affiliation: Department of Surgery, Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Tugmen
authors.affiliation: Department of Hematology, Tepecik Training and Research Hospital, Izmir, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Ceylan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D016207:Cytokines / Q000097:blood; D005260:Female; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016753:Interleukin-10 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000601:surgery*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D016559:Tacrolimus / Q000627:therapeutic use; D016212:Transforming Growth Factor beta / Q000097:blood*
chemical_list: D015415:Biomarkers; D016207:Cytokines; C508609:IL10 protein, human; D007166:Immunosuppressive Agents; D016212:Transforming Growth Factor beta; D016753:Interleukin-10; D003404:Creatinine; D016559:Tacrolimus