title: Personalizing Biomaterials for Precision Nanomedicine Considering the Local Tissue Microenvironment.
abstract: New advances in (nano)biomaterial design coupled with the detailed study of tissue-biomaterial interactions can open a new chapter in personalized medicine, where biomaterials are chosen and designed to match specific tissue types and disease states. The notion of a "one size fits all" biomaterial no longer exists, as growing evidence points to the value of customizing material design to enhance (pre)clinical performance. The complex microenvironment in vivo at different tissue sites exhibits diverse cell types, tissue chemistry, tissue morphology, and mechanical stresses that are further altered by local pathology. This complex and dynamic environment may alter the implanted material's properties and in turn affect its in vivo performance. It is crucial, therefore, to carefully study tissue context and optimize biomaterials considering the implantation conditions. This practice would enable attaining predictable material performance and enhance clinical outcomes.
authors.affiliation: Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449, Cambridge, MA, USA.
authors.forename: Nuria
authors.initials: N
authors.lastname: Oliva
authors.affiliation: Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449, Cambridge, MA, USA.
authors.forename: Shimon
authors.initials: S
authors.lastname: Unterman
authors.affiliation: Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449, Cambridge, MA, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449, Cambridge, MA, USA.|School of Engineering and Materials Science, Queen Mary University of London, London, UK.
authors.forename: João
authors.initials: J
authors.lastname: Conde
authors.affiliation: Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449, Cambridge, MA, USA.
authors.forename: Hyun Seok
authors.initials: HS
authors.lastname: Song
authors.affiliation: Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449, Cambridge, MA, USA.|Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
authors.forename: Natalie
authors.initials: N
authors.lastname: Artzi
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D015316:Genetic Therapy; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D050997:Nanomedicine; D049329:Nanostructures / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D057285:Precision Medicine; D034741:RNA, Small Interfering / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D020100:Hydrogels; D034741:RNA, Small Interfering
keywords: hydrogels; multifunctional materials; nanofillers; nanomaterials; precision medicine; theranostics; tissue microenvironment