title: Antitumor phenylpropanoids found in essential oils.
abstract: The search for new bioactive substances with anticancer activity and the understanding of their mechanisms of action are high-priorities in the research effort toward more effective treatments for cancer. The phenylpropanoids are natural products found in many aromatic and medicinal plants, food, and essential oils. They exhibit various pharmacological activities and have applications in the pharmaceutical industry. In this review, the anticancer potential of 17 phenylpropanoids and derivatives from essential oils is discussed. Chemical structures, experimental report, and mechanisms of action of bioactive substances are presented.
authors.affiliation: Núcleo de Farmácia, Universidade Federal de Sergipe, 58051-970 Lagarto, SE, Brazil.
authors.forename: Adriana Andrade
authors.initials: AA
authors.lastname: Carvalho
authors.affiliation: Departamento de Farmácia, Universidade Federal de Sergipe, 49100-000 São Cristóvão, SE, Brazil.
authors.forename: Luciana Nalone
authors.initials: LN
authors.lastname: Andrade
authors.affiliation: Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CP 5009, 58051-970 João Pessoa, PB, Brazil.
authors.forename: Élida Batista Vieira
authors.initials: ÉB
authors.lastname: de Sousa
authors.affiliation: Departamento de Farmácia, Universidade Federal de Sergipe, 49100-000 São Cristóvão, SE, Brazil ; Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CP 5009, 58051-970 João Pessoa, PB, Brazil.
authors.forename: Damião Pergentino
authors.initials: DP
authors.lastname: de Sousa
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D005054:Eugenol / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009822:Oils, Volatile / Q000737:chemistry / Q000627:therapeutic use*; D010938:Plant Oils / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D009822:Oils, Volatile; D010938:Plant Oils; D005054:Eugenol