title: Terazosin for the treatment of trauma-related nightmares: a report of 4 cases.
abstract: The selective α1-adrenergic antagonist prazosin has been shown in multiple studies to be effective in targeting trauma-related nightmares in posttraumatic stress disorder. There are limited data regarding the effectiveness of another selective α1-adrenergic antagonist terazosin for the treatment of trauma-related nightmares. We present 4 cases in which terazosin was effectively used to treat nightmares as a second-line agent after prazosin failure. Further studies are needed to validate terazosin as an alternative to prazosin for the treatment of posttraumatic stress disorder-related nightmares.
authors.affiliation: James A. Haley Veterans' Hospital, Tampa, FL.
authors.forename: Anjali
authors.initials: A
authors.lastname: Nirmalani-Gandhy
authors.forename: Deborah
authors.initials: D
authors.lastname: Sanchez
authors.forename: Glenn
authors.initials: G
authors.lastname: Catalano
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000627:therapeutic use; D000368:Aged; D004325:Dreams / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy* / Q000523:psychology*; D016896:Treatment Outcome
chemical_list: D000317:Adrenergic alpha-Antagonists; C041226:Terazosin; D011224:Prazosin