title: Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid β-induced cytotoxicity and amyloid β aggregation.
abstract: Nitraria retusa is a halophyte species that is distributed in North Africa and used as a traditional medicinal plant. In this study, N. retusa ethanol extract and its constituent isorhamnetin (IRA) protected against amyloid β (Aβ)-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. An in vitro Aβ aggregation assay suggested that IRA destabilizes Aβ fibrils.
authors.affiliation: a Graduate School of Life and Environmental Sciences , University of Tsukuba , Tsukuba , Japan.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Iida
authors.forename: Takeo
authors.initials: T
authors.lastname: Usui
authors.forename: Feten
authors.initials: F
authors.lastname: Zar Kalai
authors.forename: Junkyu
authors.initials: J
authors.lastname: Han
authors.forename: Hiroko
authors.initials: H
authors.lastname: Isoda
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nagumo
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology; D000682:Amyloid / Q000187:drug effects; D016229:Amyloid beta-Peptides / Q000378:metabolism; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D066263:Protein Aggregation, Pathological / Q000188:drug therapy* / Q000473:pathology; D011794:Quercetin / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D010936:Plant Extracts; C047368:3-methylquercetin; D011794:Quercetin
keywords: Alzheimer’s disease; amyloid β; isorhamnetin