title: Comparisons of different metabolic syndrome definitions and associations with coronary heart disease, stroke, and peripheral arterial disease in a rural Chinese population.
abstract: OBJECTIVE
  We estimated the prevalence of metabolic syndrome (MetS) and compared associations of different MetS definitions with coronary heart disease (CHD), stroke, and peripheral arterial disease (PAD) in a rural Chinese population.
  
  
  METHODS
  Among 4,748 residents (2,145 men and 2,603 women) aged 30+ years in rural China from 2006 to 2007, the prevalence of MetS was estimated by using five different definitions: modified World Health Organization (WHO), Chinese Diabetes Society (CDS), the updated National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) for Asian-Americans, International Diabetes Federation (IDF), and Joint Interim Statement (JIS). Multivariable logistic regression analyses were implemented to estimate the association between MetS and the prevalence of CHD, stroke and PAD, respectively.
  
  
  RESULTS
  Prevalence of MetS in men was 11.5% (WHO), 14.8% (CDS), 32.4% (NCEP-ATP III), 27.5% (IDF) and 39.7% (JIS) and in women was 15.7% (WHO), 20.7% (CDS), 54.2% (NCEP-ATP III), 51.5% (IDF) and 54.2% (JIS), respectively. Respective ORs (95% CI) for associating MetS with CHD in men were 1.79 (1.02-3.17), 1.25 (0.69-2.26), 1.61 (1.01-2.58), 1.84 (1.14-2.96), and 1.53 (0.96-2.43). Corresponding ORs (95% CI) for stroke in men were 2.18 (95% CI 1.20 to 3.97), 2.20 (95% CI 1.25 to 3.89), 1.71 (95% CI 1.02 to 2.84), 1.30 (95% CI 0.77 to 2.23), and 1.61 (95% CI 0.97 to 2.68), respectively. In women, CHD and stroke were significantly associated with MetS using all five definitions of MetS. In addition, PAD was associated with all five MetS definitions in men, but not in women. Only hyperglycemia and BMI were significantly associated with PAD in women.
  
  
  CONCLUSIONS
  In this rural Chinese population, the JIS, IDF and CDS criteria may not be more suitable than WHO and updated NCEP-ATPIII definitions for screening high-risk individuals and estimating the risk of CHD and stroke from MetS, especially in men.
authors.affiliation: Department of Clinical Biochemistry, Chinese PLA General Hospital, Beijing, China; Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Jiangping
authors.initials: J
authors.lastname: Wen
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Jingang
authors.initials: J
authors.lastname: Yang
authors.affiliation: Cardiovascular Disease Institute, Beijing Military Area Command General Hospital, Beijing, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Clinical and Epidemiological Research Center, the Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
authors.forename: Yuanbo
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.
authors.forename: Fenghua
authors.initials: F
authors.lastname: Wang
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.
authors.forename: Xinrong
authors.initials: X
authors.lastname: Duan
authors.affiliation: Department of Laboratory Medicine, Handan 3rd Hospital, Handan, Hebei Province, China.
authors.forename: Xilin
authors.initials: X
authors.lastname: Lu
authors.affiliation: School of Public Health, Peking University, Beijing, China.
authors.forename: Qiushan
authors.initials: Q
authors.lastname: Tao
authors.affiliation: Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of Clinical Biochemistry, Chinese PLA General Hospital, Beijing, China.
authors.forename: Yaping
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.
authors.forename: Ningli
authors.initials: N
authors.lastname: Wang
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology*; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000150:complications*; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D012424:Rural Population; D020521:Stroke / Q000150:complications*