title: Micro-ribonucleic acid 143 (MiR-143) inhibits oral squamous cell carcinoma (OSCC) cell migration and invasion by downregulation of phospho-c-Met through targeting CD44 v3.
abstract: OBJECTIVE
  The aim of this study was to investigate the roles and mechanisms of Micro-ribonucleic acid 143 (miR-143) in oral squamous cell carcinoma cells.
  
  
  METHODS
  Following the detection of miR-143 expression, cell proliferation, migration, and invasion assays and Western blot analysis were conducted in the oral squamous cell carcinoma (OSCC) cell lines.
  
  
  RESULTS
  We found that the expression of miR-143 was significantly decreased in the OSCC cell lines (SCC-4, Tca-8113, CAL-27) and tumor tissues. Meanwhile, miR-143 was significantly correlated with the migration and invasion in OSCC cell lines. Further investigation revealed that the expression level of miR-143 was opposite to that of its potential target gene-CD44 v3 and was also related to phospho-c-Met activation.
  
  
  CONCLUSIONS
  miR-143 could exert significantly suppressive effects on the ability of migration and invasion in OSCC cell lines, and the mechanism of this might be related to the activity of phospho-c-met though the CD44 v3/HGF signal. miR-143 could thus provide new applications for the treatment of OSCC.
authors.affiliation: Department of Stomatology, Chengdu Military General Hospital, NO.270, Rongdu Road, Jingniu Zone, Chengdu, 610038, Sichuan, P. R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Stomatology, Chengdu Military General Hospital, NO.270, Rongdu Road, Jingniu Zone, Chengdu, 610038, Sichuan, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Stomatology, Chengdu Military General Hospital, NO.270, Rongdu Road, Jingniu Zone, Chengdu, 610038, Sichuan, P. R. China.
authors.forename: Shuyong
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Stomatology, Chengdu Military General Hospital, NO.270, Rongdu Road, Jingniu Zone, Chengdu, 610038, Sichuan, P. R. China.
authors.forename: Haiyuan
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Stomatology, Chengdu Military General Hospital, NO.270, Rongdu Road, Jingniu Zone, Chengdu, 610038, Sichuan, P. R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Tang
authors.affiliation: Department of Stomatology, Chengdu Military General Hospital, NO.270, Rongdu Road, Jingniu Zone, Chengdu, 610038, Sichuan, P. R. China. Electronic address: biolimingzhe@163.com.
authors.forename: Mingzhe
authors.initials: M
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D015153:Blotting, Western; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction; D014162:Transfection
chemical_list: D014408:Biomarkers, Tumor; C542359:MIRN143 microRNA, human; D035683:MicroRNAs; D019859:Proto-Oncogene Proteins c-met