title: Spontaneous hepatitis C viral clearance and hepatitis C chronic infection are associated with distinct cytokine profiles in Mexican patients.
abstract: The mechanisms related to the spontaneous clearance of hepatitis C virus (HCV) have been primarily studied in regions where the infection is endemic. Results of prior studies have been extrapolated to populations with low endemicity, such as Mexico. Herein, we determined the cytokine profiles in serum samples from Mexican patients who spontaneously cleared HCV and patients chronically infected with HCV genotype 1a. Chronic HCV-infected patients displayed increased interleukin (IL)-8 and regulated upon activation, normal T-cell expressed and secreted (CCL-5) secretion, whereas patients who spontaneously cleared HCV showed augmented levels of IL-1 alpha, tumour necrosis factor-alpha, transforming growth factor-beta, monocyte chemoattractant protein-2 (CCL-8), IL-13 and IL-15. Our study suggests that cytokine profiles may predict disease outcome during HCV infection.
authors.affiliation: Unidad de Inmunovirología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.
authors.forename: Nora A
authors.initials: NA
authors.lastname: Fierro
authors.affiliation: Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.
authors.forename: Karina
authors.initials: K
authors.lastname: González-Aldaco
authors.affiliation: Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.
authors.forename: Rafael
authors.initials: R
authors.lastname: Torres-Valadez
authors.affiliation: Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.
authors.forename: Maria E
authors.initials: ME
authors.lastname: Trujillo-Trujillo
authors.affiliation: Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.
authors.forename: Sonia
authors.initials: S
authors.lastname: Roman
authors.affiliation: Unidad de Inmunovirología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Trujillo-Ochoa
authors.affiliation: Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México.
authors.forename: Arturo
authors.initials: A
authors.lastname: Panduro
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D005260:Female; D005355:Fibrosis; D016174:Hepacivirus / Q000276:immunology*; D019698:Hepatitis C, Chronic / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D008099:Liver / Q000821:virology*; D008297:Male; D008800:Mexico; D008875:Middle Aged; D012367:RNA, Viral / Q000302:isolation & purification*; D012075:Remission, Spontaneous; D019562:Viral Load / Q000276:immunology*
chemical_list: D016207:Cytokines; D012367:RNA, Viral