title: A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy.
abstract: A DT-diaphorase-activatable theranostic prodrug, which contains camptothecin, a self-immolative linker and a trigger group, has been developed for the detection of DT-diaphorase, tracking of drug release and selectively killing cancer cells over-expressed with DT-diaphorase. This strategy may offer a new approach for the development of enzyme-catalyzed theranostic anticancer therapeutics.
authors.affiliation: College of Materials Science & Engineering, State Key Lab of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, P. R. China. shzhwu@scut.edu.cn mcfzeng@scut.edu.cn.
authors.forename: Peilian
authors.initials: P
authors.lastname: Liu
authors.forename: Jiangsheng
authors.initials: J
authors.lastname: Xu
authors.forename: Donghang
authors.initials: D
authors.lastname: Yan
authors.forename: Peisheng
authors.initials: P
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Zeng
authors.forename: Bowen
authors.initials: B
authors.lastname: Li
authors.forename: Shuizhu
authors.initials: S
authors.lastname: Wu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002166:Camptothecin / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D065546:Drug Liberation; D006801:Humans; D051379:Mice; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism*; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology*; D011422:Propionates / Q000737:chemistry / Q000494:pharmacology*; D011809:Quinones / Q000737:chemistry / Q000494:pharmacology*; D000068936:Theranostic Nanomedicine
chemical_list: D000970:Antineoplastic Agents; D011355:Prodrugs; D011422:Propionates; D011809:Quinones; D016660:NAD(P)H Dehydrogenase (Quinone); D002166:Camptothecin