title: Ridge regeneration of damaged extraction sockets using rhBMP-2: an experimental study in canine.
abstract: OBJECTIVE
  This study evaluated the dimensional ridge alteration in a buccal-bone-deficient extraction socket, and ridge regeneration following socket grafting accompanied by recombinant human bone morphogenetic protein 2 (rhBMP-2) or a collagen membrane covering.
  
  
  METHODS
  In five beagle dogs, entire buccal bone of the extracted sockets of premolars was surgically removed and immediately grafted using one of the following graft protocols: (1) sham surgery without any grafting, and grafting with (2) deproteinized bovine bone mineral (DBBM), (3) DBBM/rhBMP-2 and (4) DBBM covered with a collagen membrane (DBBM/Membrane). Quantitative/qualitative analyses were performed radiographically/histologically after 8 weeks.
  
  
  RESULTS
  Buccal-deficient extraction sockets healed with significant reduction in buccolingual dimension along the entire length of the socket, but all grafting techniques reduced the dimensional changes compared to the non-grafted control sites. Histologically, sites received DBBM only exhibited minimal regeneration, whereas sites grafted with DBBM/rhBMP-2 or DBBM/Membrane exhibited greater new bone formation extending the entire augmented area.
  
  
  CONCLUSIONS
  Buccal-bone-deficiency may lead to significant volume reduction after tooth extraction along the entire length of the socket, and socket grafting accompanied by rhBMP-2 or covered with a membrane can be candidate therapies for preservation of the buccolingual dimension and successful ridge regeneration.
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors.forename: Jung-Seok
authors.identifier: http://orcid.org/0000-0003-1276-5978
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors.forename: Jae-Suk
authors.initials: JS
authors.lastname: Jung
authors.affiliation: Department of Orthopedic Surgery, Dongguk University Ilsan Hospital, Goyang, Korea.
authors.forename: Gun-Il
authors.initials: GI
authors.lastname: Im
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Gwanak-gu, Seoul, Korea.
authors.forename: Byung-Soo
authors.initials: BS
authors.lastname: Kim
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.
authors.forename: Kyoo-Sung
authors.initials: KS
authors.lastname: Cho
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea.|Department of Applied Life Science, BK21 PLUS Project, College of Dentistry, Yonsei University, Seoul, Korea.
authors.forename: Chang-Sung
authors.initials: CS
authors.lastname: Kim
mesh_terms: D016301:Alveolar Bone Loss / Q000188:drug therapy* / Q000601:surgery; D000540:Alveolar Ridge Augmentation / Q000379:methods; D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use; D002417:Cattle; D003094:Collagen; D004285:Dogs; D006801:Humans; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D011897:Random Allocation; D011994:Recombinant Proteins / Q000627:therapeutic use; D014081:Tooth Extraction / Q000009:adverse effects; D020390:Tooth Socket / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D055114:X-Ray Microtomography / Q000379:methods
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D055396:Bone Morphogenetic Protein 2; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D003094:Collagen
keywords: alveolar ridge augmentation; bone morphogenetic protein 2; guided bone regeneration; ooth extraction; ridge preservation