title: Treatment of severe non-infectious uveitis in high-risk conditions (Part I): pregnancy and malignancies, management and safety issues.
abstract: BACKGROUND
  Management of patients with severe immune-mediated uveitis requires the use of immunosuppressive drugs in selected cases. This may be especially challenging in certain patients with concomitant conditions, which could increase the risk of side effects or modify guidelines for the use of such drugs. Therapeutic decision-making and management may be of particular difficulty in pregnancy as well as in patients with associated malignancies unrelated to a specific ophthalmic inflammatory condition.
  
  
  METHODS
  The main aim of this review is to provide an updated comprehensive practical guide for practitioners regarding the therapeutic decision-making and management of patients with severe immune-mediated uveitis in the context of pregnancy and malignancies.
  
  
  CONCLUSIONS
  Management of patients with immune-mediated uveitis requiring immunosuppressive/immunomodulatory drugs might be particularly complicated by other conditions affecting their health and immune status. Clinicians should take into account such conditions, which might influence treatment response and the clinical outcome of these patients.
authors.affiliation: Uveitis Unit, Department of Ophthalmology, University Hospital of León , León , Spain +34 654403609 ; +34 987 233322 ; miguelcorderocoma@gmail.com.
authors.forename: Miguel
authors.initials: M
authors.lastname: Cordero-Coma
authors.forename: Raquel
authors.initials: R
authors.lastname: Salazar-Méndez
authors.forename: Taygan
authors.initials: T
authors.lastname: Yilmaz
mesh_terms: D000066491:Clinical Decision-Making / Q000379:methods; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000145:classification / Q000494:pharmacology; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000276:immunology; D010346:Patient Care Management / Q000379:methods; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology / Q000628:therapy; D012720:Severity of Illness Index; D014605:Uveitis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents
keywords: biological therapy; cancer; drug-related side effects; immunosuppressive agents; neoplasms; pregnancy; uveitis