title: Impact of Postreconstitution Room Temperature Storage on the Efficacy of IncobotulinumtoxinA Treatment of Dynamic Lateral Canthus Lines.
abstract: BACKGROUND
  The efficacy of botulinum neurotoxin type A after prolonged storage at room temperature is currently unknown. This randomized, double-blinded, split-face study investigated the impact of postreconstitution 25°C storage for 1 week on the clinical efficacy of incobotulinumtoxinA in the treatment of lateral canthus lines.
  
  
  METHODS
  Twenty-one participants with at least mild to moderate crow's feet at maximum contraction on the Crow's Feet Grading Scale (CFGS) underwent injection to each lateral canthus area with 10 U of freshly reconstituted and room temperature-stored product and followed for 4 months. Responders were defined as those demonstrating at least a 1-point improvement on their CFGS score.
  
  
  RESULTS
  At each visit (2 weeks and 1, 2, 3, and 4 months), there was no statistical difference in the rate of responders between the fresh and the stored products. In addition, the percentage of responders displaying a 2-point versus a 1-point improvement and response longevity did not statistically differ between both products for the entire 4-month study duration.
  
  
  CONCLUSIONS
  Prolonged storage of incobotulinumtoxinA at room temperature does not appear to significantly alter its efficacy or longevity in the treatment of dynamic lateral canthus lines.
authors.affiliation: *Premier Image Cosmetic & Laser Surgery and Department of Otolaryngology, Emory University, Atlanta, Georgia; †Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Wayne State University, Detroit, Michigan; ‡Department of Otolaryngology, Wayne State University, Detroit, Michigan.
authors.forename: Danny J
authors.initials: DJ
authors.lastname: Soares
authors.forename: Louis M
authors.initials: LM
authors.lastname: Dejoseph
authors.forename: Giancarlo F
authors.initials: GF
authors.lastname: Zuliani
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Liebertz
authors.forename: Vivek-Sagar M
authors.initials: VS
authors.lastname: Patel
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D003357:Cosmetic Techniques; D004311:Double-Blind Method; D004356:Drug Storage; D005123:Eye; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D015595:Skin Aging / Q000187:drug effects*; D013696:Temperature; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A; C545476:incobotulinumtoxinA