title: Therapy Stratifications and Novel Approach in Pursuit of AIDS Related Kaposi's Sarcoma Management- A paradigm for Non Invasiveness.
abstract: Cancer in individuals suffering with HIV and AIDS has become a common source of morbidity and mortality, especially in the underdeveloped world in which Kaposi's sarcoma is the most occurring tumor of vascular endothelium frequently seen in patients suffering from AIDS. Suffering individuals are invariably co-infected with HIV and HHV-8 virus. The conventional modes for chemotherapies may be clinically useful in patients with Kaposi's sarcoma. Though advancements in treatment modalities of AIDS related Kaposi's sarcoma have been successfully achieved, till date an exclusive therapy of golden standard has not been principally defined that can deliver the drug via non-invasive route. Novel concepts of treatment primarily address the factors that are associated with the pathogenesis of critical disease. On the other hand local therapies are aimed at eradicating primary lesions; and systemic chemotherapies are aimed to treat widespread visceral involvement. Increased understanding of the mechanisms underlying viral tumorigenesis will hopefully portray new therapeutic strategies. This review discusses novel drug delivery strategies that have been investigated for the effective and safe management of AIDS related kaposi's sarcoma. The review also highlights, the lipid based ultradeformable vesicular system that offers attractive drug delivery platform capable of delivering its payload without using invasive technique. These systems offer advance models for efficacious treatment of the future therapy aiming Kaposi's sarcoma.
authors.forename: Meenu
authors.initials: M
authors.lastname: Sharma
authors.affiliation: Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura - 281001, Uttar Pradesh, INDIA. vijay_ceutics07@yahoo.co.in.
authors.forename: Vijay
authors.initials: V
authors.lastname: Sharma
authors.forename: Kamla
authors.initials: K
authors.lastname: Pathak
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D016503:Drug Delivery Systems; D015195:Drug Design; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D012514:Sarcoma, Kaposi / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents