title: Amniotic fluid LPCAT1 mRNA correlates with the lamellar body count.
abstract: Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is required in the biosynthesis of pulmonary surfactant. This short communication describes our assessment of LPCAT1 mRNA levels in human amniotic fluid. We found a direct correlation between LPCAT1 mRNA copies and the amniotic fluid lamellar body count (LBC). This finding corroborates an association between LPCAT1 and surfactant phospholipid biosynthesis in humans. It may provide a model for future research in perinatal medicine.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Welch
authors.forename: Michael K
authors.initials: MK
authors.lastname: Shaw
authors.forename: Kathryn C
authors.initials: KC
authors.lastname: Welch
mesh_terms: D008243:1-Acylglycerophosphocholine O-Acyltransferase / Q000235:genetics*; D056809:Alveolar Epithelial Cells / Q000378:metabolism / Q000648:ultrastructure; D000653:Amniotic Fluid / Q000166:cytology* / Q000378:metabolism*; D005260:Female; D005325:Fetal Organ Maturity / Q000235:genetics / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism
chemical_list: D011663:Pulmonary Surfactants; D012333:RNA, Messenger; D008243:1-Acylglycerophosphocholine O-Acyltransferase; C526202:Lpcat1 protein, human