title: Anti-PIT-1 antibody syndrome; a novel clinical entity leading to hypopituitarism.
abstract: Various hypothalamic-pituitary diseases cause hypopituitarism. Inflammation related to autoimmunity also causes hypopituitarism. Hypophysitis is a representative disease caused by autoimmunity. Generally, anterior pituitary hormones are non-specifically impaired in this condition, but specific hormone defects have been reported in some cases. Anti-PIT-1 (pituitary-specific transcription factor 1) antibody syndrome is a novel clinical entity that presents an acquired combined pituitary hormone deficiency characterized by a specific defect in growth hormone, prolactin, and thyroid-stimulating hormone. Circulating anti-PIT-1 antibody along with various autoantibodies are detected with multiple endocrine organopathy, meeting the definition of autoimmune polyglandular syndrome. Mechanistically, cytotoxic T lymphocytes that specifically react with PIT-1 protein play an important role in the development of this syndrome.
authors.forename: Hironori
authors.initials: H
authors.lastname: Bando
authors.forename: Genzo
authors.initials: G
authors.lastname: Iguchi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Ryoko
authors.initials: R
authors.lastname: Hidaka-Takeno
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takahashi
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D007018:Hypopituitarism / Q000150:complications / Q000235:genetics / Q000276:immunology*; D016884:Polyendocrinopathies, Autoimmune / Q000235:genetics / Q000276:immunology; D013577:Syndrome; D050817:Transcription Factor Pit-1 / Q000276:immunology* / Q000502:physiology
chemical_list: D001323:Autoantibodies; D050817:Transcription Factor Pit-1