title: Catheter Ablation of Premature Ventricular Contractions Originating in the Aortic Sinus Cusp or Great Cardiac Vein: Two QRS Morphologies with One Origin.
abstract: BACKGROUND
  Premature ventricular contractions (PVCs) originating from aortic sinus cusps (ASCs) can exhibit preferential conduction to right ventricular outflow tract (RVOT).
  
  
  OBJECTIVE
  This study aimed to examine the electrophysiological characteristics for guiding catheter ablation in patients with two morphological types of PVCs that originate from ASCs or the great cardiac vein (GCV).
  
  
  METHODS
  We analyzed electrocardiogram from 10 patients with PVCs of two QRS morphologies. The patients who exhibited dominant left bundle branch block (LBBB) QRS morphology and less right bundle branch block (RBBB) morphology were designated as group 1 (n = 7), and those with dominant RBBB QRS morphology were designated as group 2 (n = 3). During PVCs, electroanatomical mapping was performed in both RVOT and ASC in group 1 and only performed in ASC or GCV in group 2.
  
  
  RESULTS
  In group 1, the earliest ventricular activation preceding the onset of the QRS complex (V-QRS) was recorded for 27 ± 6 ms (range 18-36 ms) in RVOT and 25 ± 6 ms (range 18-34 ms) in the ASC, while V-QRS was recorded for 28 ms, 42 ms, 40 ms in the ASC or GCV in group 2. All patients were successfully ablated at one site finally, including left coronary cusp in seven, left-right coronary cusp commissure in two, and GCV in one. None of the patients experienced recurrence or complications during the 18.4 ± 5.1 (range 6-24 months) months of follow-up.
  
  
  CONCLUSIONS
  Two QRS morphologies (LBBB and RBBB with inferior axis) in PVCs could be a predictor of PVCs originating from ASC or GCV.
authors.affiliation: Weifang Medical University, Weifang, China.
authors.forename: Yu-Bin
authors.initials: YB
authors.lastname: Wang
authors.affiliation: Weifang Medical University, Weifang, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Ma
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases & Cardiology Department, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Jian-Zeng
authors.initials: JZ
authors.lastname: Dong
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases & Cardiology Department, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Bai
authors.affiliation: FuWai Hospital, National Center for Cardiovascular Diseases of China, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases & Cardiology Department, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Song-Nan
authors.initials: SN
authors.lastname: Li
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases & Cardiology Department, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Rong-Hui
authors.initials: RH
authors.lastname: Yu
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases & Cardiology Department, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: De-Yong
authors.initials: DY
authors.lastname: Long
authors.affiliation: National Clinical Research Center for Cardiovascular Diseases & Cardiology Department, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Ma
authors.affiliation: FuWai Hospital, National Center for Cardiovascular Diseases of China, Beijing, China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Chu
mesh_terms: D000328:Adult; D018780:Body Surface Potential Mapping / Q000379:methods; D002037:Bundle-Branch Block / Q000175:diagnosis* / Q000601:surgery*; D017115:Catheter Ablation / Q000379:methods; D003330:Coronary Vessel Anomalies / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012850:Sinus of Valsalva / Q000002:abnormalities / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods; D018879:Ventricular Premature Complexes / Q000175:diagnosis* / Q000601:surgery*
keywords: aortic sinus cusp; catheter ablation; electroanatomical mapping; great cardiac vein; premature ventricular contraction