title: Enhancing radiolytic stability upon concentration of tritium-labeled pharmaceuticals utilizing centrifugal evaporation.
abstract: Tritium radiopharmaceuticals are often used in drug development because of their desirable specific activity. The inherent instability of these radioactive tracers often leads to a requirement to purify prior to use. Purification methodologies such as preparative chromatography and solid/liquid extractions often utilize water as a solvent, which is not suitable for long-term storage and necessitates removal. Rotary evaporation has traditionally been utilized for the removal of this unwanted solvent, however, this method has been shown to lead to decomposition of the tritium species in some cases. Centrifugal evaporation is a milder concentration method which has been demonstrated to effectively remove solvents. In this study, we show that centrifugal evaporation leads to effective concentration of tritium samples without the decomposition typically observed by rotary evaporation.
authors.affiliation: Analytical and Process Chemistry, Merck Research Laboratories, Rahway, NJ, 07065, USA.
authors.forename: Rosemary
authors.initials: R
authors.lastname: Marques
authors.affiliation: Analytical and Process Chemistry, Merck Research Laboratories, Rahway, NJ, 07065, USA.
authors.forename: Roy
authors.initials: R
authors.lastname: Helmy
authors.affiliation: Analytical and Process Chemistry, Merck Research Laboratories, Rahway, NJ, 07065, USA.
authors.forename: David
authors.initials: D
authors.lastname: Waterhouse
mesh_terms: D002498:Centrifugation; D005612:Freeze Drying; D019275:Radiopharmaceuticals / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D014316:Tritium / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals; D012997:Solvents; D014316:Tritium
keywords: centrifugal evaporation; purification; tritium-labeled pharmaceuticals