title: Peptide self-assembly triggered by metal ions.
abstract: Through their unique and specific interactions with various metal ions, naturally occurring proteins control structures and functions of many biological processes and functions in organisms. Inspired by natural metallopeptides, chemists have developed artificial peptides which coordinate with metal ions through their functional groups either for introducing a special reactivity or for constructing nanostructures. However, the design of new coordination peptides requires a deep understanding of the structures, assembly properties, and dynamic behaviours of such peptides. This review briefly discusses strategies of peptide self-assembly induced by metal coordination to different natural and non-natural binding sites in the peptide. The structures and functions of the obtained aggregates are described as well. We also highlight some examples of a metal-induced peptide self-assembly with relevance to biotechnology applications.
authors.affiliation: Key Lab for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China. tianhe@ecust.edu.cn jcwu@ecust.edu.cn.
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Zou
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Junchen
authors.initials: J
authors.lastname: Wu
authors.forename: Jingxian
authors.initials: J
authors.lastname: Wu
authors.forename: Carsten
authors.initials: C
authors.lastname: Schmuck
authors.forename: He
authors.initials: H
authors.lastname: Tian
mesh_terms: D001665:Binding Sites; D001671:Biochemistry; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism; D008670:Metals / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding
chemical_list: D056831:Coordination Complexes; D008670:Metals; D010455:Peptides