title: Anti-malarials are anti-cancers and vice versa - one arrow two sparrows.
abstract: Repurposing is the novel means of drug discovery in modern science due to its affordability, safety and availability. Here, we systematically discussed the efficacy and mode of action of multiple bioactive, synthetic compounds and their potential derivatives which are used to treat/prevent malaria and cancer. We have also discussed the detailed molecular pathway involved in anti-cancer potentiality of an anti-malarial drug and vice versa. Although the causative agents, pathophysiology and manifestation of both the diseases are different but special emphasis has been given on similar pathways governing disease manifestation and the drugs which act through deregulating those pathways. Finally, a future direction has been speculated to combat these two diseases by a single agent developed using nanotechnology. Extended combination and new formulation of existing drugs for one disease may lead to the discovery of drug for other diseases like an arrow for two sparrows.
authors.affiliation: School of Biotechnology, Department of Cancer Biology, KIIT University, Campus-11, Patia, Bhubaneswar, Odisha 751024, India. Electronic address: cnkundu@gmail.com.
authors.forename: Chanakya Nath
authors.initials: CN
authors.lastname: Kundu
authors.affiliation: School of Biotechnology, Department of Cancer Biology, KIIT University, Campus-11, Patia, Bhubaneswar, Odisha 751024, India.
authors.forename: Sarita
authors.initials: S
authors.lastname: Das
authors.affiliation: School of Biotechnology, Department of Cancer Biology, KIIT University, Campus-11, Patia, Bhubaneswar, Odisha 751024, India.
authors.forename: Anmada
authors.initials: A
authors.lastname: Nayak
authors.affiliation: School of Biotechnology, Department of Cancer Biology, KIIT University, Campus-11, Patia, Bhubaneswar, Odisha 751024, India.
authors.forename: Shakti Ranjan
authors.initials: SR
authors.lastname: Satapathy
authors.affiliation: School of Biotechnology, Department of Cancer Biology, KIIT University, Campus-11, Patia, Bhubaneswar, Odisha 751024, India.
authors.forename: Dipon
authors.initials: D
authors.lastname: Das
authors.affiliation: School of Biotechnology, Department of Cancer Biology, KIIT University, Campus-11, Patia, Bhubaneswar, Odisha 751024, India.
authors.forename: Sumit
authors.initials: S
authors.lastname: Siddharth
mesh_terms: D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D055808:Drug Discovery; D058492:Drug Repositioning; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy*; D010961:Plasmodium / Q000187:drug effects
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents
keywords: Cancer; Malaria; Nanomedicine; Natural compound; Plasmodium falciparum; Synthetic compound