title: Effectiveness and safety of laparoscopic adrenalectomy of large pheochromocytoma: a prospective, nonrandomized, controlled study.
abstract: BACKGROUND
  Laparoscopic adrenalectomy (LA) is normally used to treat small-sized (<6 cm) pheochromocytoma (PCC). This study evaluated the effectiveness and safety of LA for treating large (≥6 cm) PCC.
  
  
  METHODS
  Fifty-one patients with resectable, large-sized (≥6 cm) PCC were prospectively enrolled for elective LA (n = 23) or open adrenalectomy (n = 28).
  
  
  RESULTS
  LA was converted into open adrenalectomy in 2 patients (2/23, 8.7%); LA was associated with relatively longer operative time (P = .033) but less intraoperative bleeding (P < .001), faster resumption of ambulatory status (P < .001), and shorter duration of postoperative hospitalization (P < .001). Frequency of PCC recurrence was similar between the 2 groups (P = 1.000).
  
  
  CONCLUSIONS
  LA is a feasible, effective, and safe treatment modality for large-sized (≥6 cm) PCC. LA is associated with minimal invasiveness and faster postoperative recovery.
authors.affiliation: The Second Department of Urology, The First Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, China.
authors.forename: Weigang
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Immunology, China-Japan Union Hospital, Jilin University, Changchun, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Key Laboratory of Pathobiology, Ministry of Education, School of Basic Medical Sciences, Jilin University, Changchun, China.
authors.forename: Yishu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Second Department of Urology, The First Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, China.
authors.forename: Yuantao
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Second Department of Urology, The First Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Ma
authors.affiliation: The Second Department of Urology, The First Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: The Second Department of Urology, The First Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, China.
authors.forename: Jialin
authors.initials: J
authors.lastname: Gao
authors.affiliation: The Second Department of Urology, The First Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, China. Electronic address: walkerzhouhl@163.com.
authors.forename: Honglan
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000473:pathology / Q000601:surgery*; D000315:Adrenalectomy / Q000379:methods*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D016896:Treatment Outcome
keywords: Adrenalectomy; Comparative study; Laparoscopy; Pheochromocytoma