title: Atypical chemokine receptor 2: a brake against Kaposi's sarcoma aggressiveness.
abstract: Inflammatory chemokines are instrumental players in cancer-related inflammation contributing to numerous steps during tumor progression. In Kaposi's sarcoma, we have found that downregulation of the atypical chemokine receptor 2 (ACKR2) by the KRAS/BRAF/ERK pathway profoundly affects the tumor microenvironment, unleashing accumulation of tumor-associated macrophages that sustains tumor growth. This discovery extends our understanding on the role of inflammatory chemokines in tumor biology and provides rationale for their therapeutic targeting.
authors.affiliation: Humanitas Clinical and Research Center ; Rozzano, Italy ; Department of Medical Biotechnologies and Translational Medicine; Università degli Studi di Milano ; Rozzano, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Bonecchi
authors.affiliation: Humanitas Clinical and Research Center ; Rozzano, Italy ; Department of Medical Biotechnologies and Translational Medicine; Università degli Studi di Milano ; Rozzano, Italy.
authors.forename: Benedetta
authors.initials: B
authors.lastname: Savino
authors.affiliation: Humanitas Clinical and Research Center ; Rozzano, Italy ; Department of Medical Biotechnologies and Translational Medicine; Università degli Studi di Milano ; Rozzano, Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Caronni
authors.affiliation: Humanitas Clinical and Research Center ; Rozzano, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Celesti
authors.affiliation: Humanitas Clinical and Research Center ; Rozzano, Italy ; Department of Medical Biotechnologies and Translational Medicine; Università degli Studi di Milano ; Rozzano, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.affiliation: Humanitas Clinical and Research Center ; Rozzano, Italy ; Department of Medical Biotechnologies and Translational Medicine; Università degli Studi di Milano ; Rozzano, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Locati
keywords: Kaposi's sarcoma; atypical chemokine receptors; chemokines; inflammation and cancer; macrophages