title: Factor XIII-A dynamics in acute myocardial infarction: a novel prognostic biomarker?
abstract: After acute myocardial infarction (MI) the damaged heart has to be repaired. Factor XIII (FXIII) is considered a key molecule in promoting heart healing. FXIII deficiency was associated to cardiac rupture and anomalous remodelling in MI. During MI, FXIII contributes firstly to the intracoronary thrombus formation and shortly after to heal the myocardial lesion. To quantify the real contribution of FXIII in this process, and to explore its possible prognostic role, we monitored the FXIII-A subunit levels in 350 acute MI patients during the first six days (d0-d5) plus a control at 30-60 days (d30). A one-year follow-up was performed for all the patients. A transient drop in the FXIII-A mean level was noted in the whole cohort of patients (FXIII-Ad0 99.48 ± 30.5 vs FXIII-Ad5 76.51 ± 27.02; p< 0.0001). Interestingly, those who developed post-MI heart failure showed the highest drop (FXIII-Ad5 52.1 ± 25.2) and they already presented with low levels at recruitment. Similarly, those who died showed the same FXIII-A dynamic (FXIII-Ad5 54.0 ± 22.5). Conversely, patients who remained free of major adverse cardiac events, had lower consuming (FXIII-Ad0 103.6 ± 29.1 vs FXIII-Ad5 84.4 ± 24.5; p< 0.0001). Interestingly, the FXIII-A drop was independent from the amount of injury assessed by TnT and CKMB levels. The survival analysis ascribed an increased probability of early death or heart failure inversely related to FXIII-A quartiles (FXIII-A25th< 59.5 %; hazard ratio 4.25; 2.2-5.1; p< 0.0001). Different FXIII-A dynamics and levels could be utilised as early prognostic indicators during acute MI, revealing the individual potential to heal and suggesting tailored treatments to avoid heart failure or its extreme consequence.
authors.affiliation: Gemmati Donato, Ctr. Hemostasis & Thrombosis, Hematology Section, Dpt. of Medical Sciences, University of Ferrara, Ferrara, Italy, Tel.: +39 0532 237291, Fax: +39 0532 209010, E-mail: d.gemmati@unife.it.
authors.forename: Donato
authors.initials: D
authors.lastname: Gemmati
authors.forename: Giulia
authors.initials: G
authors.lastname: Zeri
authors.forename: Elisa
authors.initials: E
authors.lastname: Orioli
authors.forename: Rosella
authors.initials: R
authors.lastname: Mari
authors.forename: Stefano
authors.initials: S
authors.lastname: Moratelli
authors.forename: Marco
authors.initials: M
authors.lastname: Vigliano
authors.forename: Jlenia
authors.initials: J
authors.lastname: Marchesini
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Grossi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pecoraro
authors.forename: Antonio
authors.initials: A
authors.lastname: Cuneo
authors.forename: Roberto
authors.initials: R
authors.lastname: Ferrari
authors.forename: Mirko
authors.initials: M
authors.lastname: Pinotti
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Serino
authors.forename: Lucia
authors.initials: L
authors.lastname: Ansani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D052279:Creatine Kinase, MB Form / Q000097:blood; D026122:Factor XIIIa / Q000378:metabolism*; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000209:etiology; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D011237:Predictive Value of Tests; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D020107:Troponin T / Q000097:blood; D014945:Wound Healing
chemical_list: D015415:Biomarkers; D020107:Troponin T; D026122:Factor XIIIa; D052279:Creatine Kinase, MB Form
keywords: Factor XIII; myocardial healing; myocardial infarction; myocardial infarction biomarkers; prognosis