title: Peripheral ameloblastoma with histologically low-grade malignant features of the buccal mucosa: a case report with immunohistochemical study and genetic analysis.
abstract: Peripheral ameloblastoma (PA), a rare and unusual variant of odontogenic tumors, comprises about 1% of all ameloblastomas. PA is an exophytic growth localized to the soft tissues overlying the tooth-bearing areas of the jaws, and the initial diagnosis is often fibrous epulis. PA with histologically low-grade malignant features is extremely rare. We report a case of peripheral ameloblastoma with histologically low-grade malignant features in a 69-year-old woman that presented with a hemorrhage from a tumor on the right buccal mucosa. The tumor was surgically removed by blunt dissection, with no evidence of recurrence after two years and six months. After the case presentation, microscopic and genetic findings are discussed.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine Ehime, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Goda
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine Ehime, Japan.
authors.forename: Kohichi
authors.initials: K
authors.lastname: Nakashiro
authors.affiliation: Center of Oral Clinical Examination, Hiroshima University Hospital Hiroshima, Japan.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Ogawa
authors.affiliation: Department of Oral Maxillofacial Pathobiology, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University Hiroshima, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Takata
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine Ehime, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hamakawa
mesh_terms: D000368:Aged; D000564:Ameloblastoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005820:Genetic Testing; D006801:Humans; D007150:Immunohistochemistry; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology*; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
keywords: Peripheral ameloblastoma; buccal mucosa; odontogenic tumor