title: Weber-Christian disease with ileocolonic involvement successfully treated with infliximab.
abstract: Weber-Christian disease (WCD) is an inflammatory disease whose main histological feature is lobular panniculitis of adipose tissue. The location of panniculitis determines the clinical presentation, being the subcutaneous adipose tissue the most frequent one, followed by liver, spleen, bone marrow and mesenteric adipose tissue. Systemic corticosteroids are first line treatment, but other options should be considered if systemic symptoms are observed or in case of refractory clinical situation. We report herein a case with WCD showing orbital, mesenteric and ileocolonic involvement, which required surgical treatment and also developed postoperative recurrence. Symptoms were resolved by administration of thalidomide and, afterwards, infliximab. To our knowledge, this is the first report of Weber-Christian disease with luminal ileocolonic involvement, treated with infliximab.
authors.affiliation: José Miranda-Bautista, Alejandro Fernández-Simón, Luis Menchén, Department of Gastroenterology, "Gregorio Marañón" General Hospital-IiSGM, 28003 Madrid, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Miranda-Bautista
authors.affiliation: José Miranda-Bautista, Alejandro Fernández-Simón, Luis Menchén, Department of Gastroenterology, "Gregorio Marañón" General Hospital-IiSGM, 28003 Madrid, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Fernández-Simón
authors.affiliation: José Miranda-Bautista, Alejandro Fernández-Simón, Luis Menchén, Department of Gastroenterology, "Gregorio Marañón" General Hospital-IiSGM, 28003 Madrid, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Pérez-Sánchez
authors.affiliation: José Miranda-Bautista, Alejandro Fernández-Simón, Luis Menchén, Department of Gastroenterology, "Gregorio Marañón" General Hospital-IiSGM, 28003 Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Menchén
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001706:Biopsy; D003108:Colonic Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D000069285:Infliximab / Q000627:therapeutic use*; D010201:Panniculitis, Nodular Nonsuppurative / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D012008:Recurrence; D012074:Remission Induction; D013792:Thalidomide / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D013792:Thalidomide; D000069285:Infliximab
keywords: Crohn’s disease; Idiopathic lobular panniculitis; Ileocecal resection; Infliximab; Weber-Christian disease