title: Efficacy and safety of electroacupuncture with different acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial.
abstract: BACKGROUND
  Many patients experience nausea and vomiting during chemotherapy treatment. Evidence demonstrates that electroacupuncture is beneficial for controlling chemotherapy-induced nausea and vomiting (CINV). However, the acupoint or matching acupoint with the best efficacy for controlling CINV still remains unidentified.
  
  
  METHODS
  This study consists of a randomized controlled trial (RCT) with four parallel arms: a control group and three electroacupuncture groups (one with Neiguan (PC6), one with Zhongwan (CV12), and one with both PC6 and CV12). The control group received standard antiemetic only, while the other three groups received electroacupuncture stimulation with different acupoints besides the standard antiemetic. The intervention is done once daily from the first day (day 1) to the fourth day (day 4) during chemotherapy treatment. The primary outcome measures include frequency of nausea, vomiting and retching. The secondary outcome measures are the grade of constipation and diarrhea, electrogastrogram, assessment of quality of life, assessment of anxiety and depression, and other adverse effects during the chemotherapy. Assessments are scheduled from one day pre-chemotherapy (day 0) to the fifth day of chemotherapy (day 5). Follow-ups are done from day 6 to day 21.
  
  
  CONCLUSIONS
  The aim of this study is to evaluate the efficacy and safety of electro-acupuncture with different acupoints in the management of CINV.
  
  
  BACKGROUND
  The register number of randomized controlled trial is NCT02195908 . The date of registration was 21 July 2014.
authors.affiliation: Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. tjutcmchenbo@163.com.|Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. tjutcmchenbo@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.affiliation: Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. luanshijr@126.com.|Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. luanshijr@126.com.
authors.forename: Shu-xiang
authors.initials: SX
authors.lastname: Hu
authors.affiliation: Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. liubaohu2006@163.com.|Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. liubaohu2006@163.com.
authors.forename: Bao-hu
authors.initials: BH
authors.lastname: Liu
authors.affiliation: Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. zhaotianyi89@126.com.|Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. zhaotianyi89@126.com.
authors.forename: Tian-yi
authors.initials: TY
authors.lastname: Zhao
authors.affiliation: Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. bb2065402@163.com.|Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. bb2065402@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. liuyantjbd@163.com.|Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. liuyantjbd@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Clinical Practice Teaching Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. limingyue7@163.com.
authors.forename: Ming-yue
authors.initials: MY
authors.lastname: Li
authors.affiliation: Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. pangxingfang@163.com.|Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. pangxingfang@163.com.
authors.forename: Xing-fang
authors.initials: XF
authors.lastname: Pan
authors.affiliation: Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. Guoymxr@163.com.|Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. Guoymxr@163.com.
authors.forename: Yong-ming
authors.initials: YM
authors.lastname: Guo
authors.affiliation: Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. chenzelin328@163.com.|Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. chenzelin328@163.com.
authors.forename: Ze-lin
authors.initials: ZL
authors.lastname: Chen
authors.affiliation: Acu-moxibustion and Tuina Department of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. guoyi_168@163.com.|Acupuncture Research Center of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China. guoyi_168@163.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
mesh_terms: D015669:Acupuncture Points; D000932:Antiemetics / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D015671:Electroacupuncture / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D009325:Nausea / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D011788:Quality of Life; D012107:Research Design; D013997:Time Factors; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents