title: Preparation of azidoaryl- and azidoalkyloxazoles for click chemistry.
abstract: A series of azidoaryl- and azidoalkyl(diphenyl)oxazole scaffolds were warranted for biofilm inhibition studies. Cyclization of azidoaryl- or azidoalkyl esters of benzoin with ammonium acetate in acetic acid gives 2-azidoaryl- or 2-azidoalkyl-4,5-diphenyloxazoles. The azidoaryl esters are prepared from the corresponding azidocarboxylic acids/acid chlorides while the azidoalkyl esters are prepared from the corresponding haloalkyl esters.
authors.affiliation: Department of Periodontics, Endodontics and Dental Hygiene, University of Louisville School of Dentistry, 501 S. Preston St. Louisville, Kentucky 40292, USA.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Loner
authors.affiliation: Department of Chemistry, University of Louisville, 2320 So. Brook St. Louisville. Kentucky 40292, USA.
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Luzzio
authors.affiliation: Department of Periodontics, Endodontics and Dental Hygiene, University of Louisville School of Dentistry, 501 S. Preston St. Louisville, Kentucky 40292, USA.
authors.forename: Donald R
authors.initials: DR
authors.lastname: Demuth
keywords: Azides; Biofilms; Click chemistry; Oxazoles; Peptidomimetics