title: BRAIN HYPOTHERMIA THERAPY FOR NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY WITH A SEVERELY ELEVATED SERUM CREATINE KINASE LEVEL.
abstract: Several studies have shown that brain hypothermia therapy (BHT) after neonatal hypoxic-ischemic encephalopathy (HIE) can improve neurodevelopmental outcomes. However, there have been no reports of the neurodevelopmental outcomes for the infant with a serum creatine kinase (CK) level above 20,000 IU/L in association with neonatal HIE. We report a female infant with a very high serum CK level (26,428 IU/L) associated with neonatal asphyxia. We diagnosed this infant with moderate HIE, and BHT was achieved by head cooling within 6 hours after birth to an esophageal temperature of 34.5°C. There were no significant adverse events during BHT, and the CK level spontaneously decreased. Although we report only the short-term outcomes for this case, she presents neurodevelopmental delays at the age of 18 months. It may be correlated between high serum CK level and long-term neurodevelopmental delays.
authors.affiliation: Pediatrics, Takeda General Hospital.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Takashi
authors.initials: T
authors.lastname: Imamura
authors.forename: Hajime
authors.initials: H
authors.lastname: Maeda
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Shibukawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Shogo
authors.initials: S
authors.lastname: Kin
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Ariga
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Nagasawa
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000097:blood / Q000628:therapy*; D007231:Infant, Newborn; D011247:Pregnancy
chemical_list: D003402:Creatine Kinase