title: TGF-β1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients.
abstract: Transforming growth factor-beta 1 (TGF-β1), a member of the transforming growth factor beta family, functions as a multi-functional cytokine and plays a key role in cellular growth, proliferation, and differentiation. The 509 C/T polymorphism in the TGF-β1 gene has been implicated in the outcome of hepatitis C virus (HCV) infection; however, little is known regarding the relationship between TGF-β1 gene mutations and the development of hepatocellular carcinoma (HCC) in HCV-infected patients. The aim of the study was to evaluate the effect of the TGF-β1 polymorphisms 509 C>T on the occurrence of HCC in patients chronically infected with HCV in a Chinese Han population. The results showed that HCC patients had a higher frequency of the TGF-β1 -509 TT genotype distribution of the TGF-β1 -509 polymorphism and a lower frequency of the CC genotype. Serum TGF-β1 levels were significantly higher in patients with the TT genotype than in those with the CC genotype. In this study, we confirmed that the TGF-β1 polymorphism 509 C>T is associated with the risk of HCC in HCV-infected patients.
authors.affiliation: Department of Isotopic Laboratory, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: J
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Oncology, Taixing People's Hospital, Taixing, China.
authors.forename: Y C
authors.initials: YC
authors.lastname: Liu
authors.affiliation: Department of Central Laboratory, The Affiliated Fourth Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of Central Laboratory, The Affiliated Fourth Hospital of Jiangsu University, Zhenjiang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Clinical Laboratory, The First People's Hospital of Lianyungang, Lianyungang, China 329391156@qq.com.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1