title: Positive correlations between circulating adiponectin and MMP2 in preeclampsia pregnant.
abstract: OBJECTIVE
  The aims of the present study were to compare plasma concentrations of the adiponectin, leptin, metalloproteinases (MMP9 and MMP2) and its tissue inhibitors (TIMP1 and TIMP2) in preeclamptic (PE) and healthy pregnant (HP) groups and correlate them.
  
  
  METHODS
  A total of 105 pregnant women with pre-pregnancy body mass index (BMI) values ⩽ 30 kg/m(2) were enrolled for this study (59 PE and 46 HP). Biomarkers were measured using ELISAs.
  
  
  RESULTS
  Adiponectin (32%), leptin (45%), MMP2 (20%), TIMP1 (31%) and TIMP2 (23%) levels were higher in PE compared to HP (all P < 0.05). In addition there were positive correlations between adiponectin and MMP2 (r = 0.33; P = 0.03) and adiponectin and TIMP2 (r = 0.33; P = 0.03) in PE group, but not in HP.
  
  
  CONCLUSIONS
  Our findings show that adiponectin, leptin, MMP2, TIMP1 and TIMP2 levels are increased in PE and adiponectin may contribute to higher levels of MMP2 and TIMP2 in this disease.
authors.affiliation: Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil.
authors.forename: Nibia Mariana
authors.initials: NM
authors.lastname: Eleuterio
authors.affiliation: Department of Pharmacology, Faculty of Medicinal Sciences, University of Campinas, State University of Campinas, Campinas/SP, Brazil.
authors.forename: Ana C T
authors.initials: AC
authors.lastname: Palei
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirão Preto/SP, Brazil.
authors.forename: Jackeline S
authors.initials: JS
authors.lastname: Rangel Machado
authors.affiliation: Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto/SP, Brazil.
authors.forename: Jose E
authors.initials: JE
authors.lastname: Tanus-Santos
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirão Preto/SP, Brazil.
authors.forename: Ricardo C
authors.initials: RC
authors.lastname: Cavalli
authors.affiliation: Department of Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu/SP, Brazil. Electronic address: valsandrim@yahoo.com.br.
authors.forename: Valeria C
authors.initials: VC
authors.lastname: Sandrim
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020738:Leptin / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology; D011247:Pregnancy; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000378:metabolism; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000378:metabolism
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D019715:Tissue Inhibitor of Metalloproteinase-1; D019716:Tissue Inhibitor of Metalloproteinase-2; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9
keywords: Adiponectin; Leptin; Metalloproteinase (MMP)-2 and (MMP)-9; Preeclampsia; Tissue inhibitor of metalloproteinase (TIMP)-1 and (TIMP)-2