title: Fever and Reversible Laboratory Abnormalities Associated with Prolonged Use of Piperacillin-Tazobactam in Children.
abstract: Piperacillin-tazobactam is used frequently in pediatric patients with complicated appendicitis and other intra-abdominal infections. We report 10 pediatric patients who developed a piperacillin-tazobactam-associated adverse reaction characterized by fever, rash, hematologic abnormalities and transaminitis. Physicians should be aware of this entity in patients treated with a prolonged course of piperacillin-tazobactam. Prompt identification can obviate unnecessary diagnostic testing and treatment.
authors.affiliation: From the *Department of Pediatrics, Infectious Diseases Section, Baylor College of Medicine, Houston, Texas; and †Department of Pharmacy, Texas Children's Hospital, Houston, Texas.
authors.forename: Aesha
authors.initials: A
authors.lastname: Patel
authors.forename: Kuo-Rei
authors.initials: KR
authors.lastname: Mao
authors.forename: J Chase
authors.initials: JC
authors.lastname: McNeil
authors.forename: Sheldon L
authors.initials: SL
authors.lastname: Kaplan
authors.forename: Jesus G
authors.initials: JG
authors.lastname: Vallejo
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D005334:Fever / Q000209:etiology*; D006801:Humans; D007223:Infant; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D010878:Piperacillin / Q000008:administration & dosage / Q000009:adverse effects; D000077725:Piperacillin, Tazobactam Drug Combination; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin