title: Impact of an intra-cycle motion correction algorithm on overall evaluability and diagnostic accuracy of computed tomography coronary angiography.
abstract: OBJECTIVE
  The aim of this study was to evaluate the impact of a novel intra-cycle motion correction algorithm (MCA) on overall evaluability and diagnostic accuracy of cardiac computed tomography coronary angiography (CCT).
  
  
  METHODS
  From a cohort of 900 consecutive patients referred for CCT for suspected coronary artery disease (CAD), we enrolled 160 (18 %) patients (mean age 65.3 ± 11.7 years, 101 male) with at least one coronary segment classified as non-evaluable for motion artefacts. The CCT data sets were evaluated using a standard reconstruction algorithm (SRA) and MCA and compared in terms of subjective image quality, evaluability and diagnostic accuracy.
  
  
  RESULTS
  The mean heart rate during the examination was 68.3 ± 9.4 bpm. The MCA showed a higher Likert score (3.1 ± 0.9 vs. 2.5 ± 1.1, p < 0.001) and evaluability (94%vs.79 %, p < 0.001) than the SRA. In a 45-patient subgroup studied by clinically indicated invasive coronary angiography, specificity, positive predictive value and accuracy were higher in MCA vs. SRA in segment-based and vessel-based models, respectively (87%vs.73 %, 50%vs.34 %, 85%vs.73 %, p < 0.001 and 62%vs.28 %, 66%vs.51 % and 75%vs.57 %, p < 0.001). In a patient-based model, MCA showed higher accuracy vs. SCA (93%vs.76 %, p < 0.05).
  
  
  CONCLUSIONS
  MCA can significantly improve subjective image quality, overall evaluability and diagnostic accuracy of CCT.
  
  
  CONCLUSIONS
  Cardiac computed tomographic coronary angiography (CCT) allows non-invasive evaluation of coronary arteries. Intra-cycle motion correction algorithm (MCA) allows for compensation of coronary motion. An MCA improves image quality, CCT evaluability and diagnostic accuracy.
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy. gianluca.pontone@ccfm.it.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Pontone
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.|Department of Cardiovascular Sciences and Community Health, University of Milan, Milan, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Andreini
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Bertella
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Baggiano
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Saima
authors.initials: S
authors.lastname: Mushtaq
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Loguercio
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Segurini
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Conte
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Virginia
authors.initials: V
authors.lastname: Beltrama
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Annoni
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Formenti
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Petullà
authors.affiliation: Department of Cardiology, University of Foggia, Foggia, Italy.
authors.forename: Andrea I
authors.initials: AI
authors.lastname: Guaricci
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.|Department of Cardiovascular Sciences and Community Health, University of Milan, Milan, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Montorsi
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Trabattoni
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.|Department of Cardiovascular Sciences and Community Health, University of Milan, Milan, Italy.
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Bartorelli
authors.affiliation: Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, 20138, Milan, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Pepi
mesh_terms: D000368:Aged; D000465:Algorithms; D016477:Artifacts; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D009038:Motion; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Accuracy; Cardiac computed tomography; Coronary artery disease; Intra-cycle motion correction algorithm; Motion artefacts