title: Effects of monoterpenes on ion channels of excitable cells.
abstract: Monoterpenes are a structurally diverse group of phytochemicals and a major constituent of plant-derived 'essential oils'. Monoterpenes such as menthol, carvacrol, and eugenol have been utilized for therapeutical purposes and food additives for centuries and have been reported to have anti-inflammatory, antioxidant and analgesic actions. In recent years there has been increasing interest in understanding the pharmacological actions of these molecules. There is evidence indicating that monoterpenes can modulate the functional properties of several types of voltage and ligand-gated ion channels, suggesting that some of their pharmacological actions may be mediated by modulations of ion channel function. In this report, we review the literature concerning the interaction of monoterpenes with various ion channels.
authors.affiliation: Laboratory of Functional Lipidomics, Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates. Electronic address: Murat_Oz@uaeu.ac.ae.
authors.forename: Murat
authors.initials: M
authors.lastname: Oz
authors.affiliation: Laboratory of Functional Lipidomics, Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
authors.forename: Yosra
authors.initials: Y
authors.lastname: Lozon
authors.affiliation: Laboratory of Functional Lipidomics, Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Sultan
authors.affiliation: Department of Biological Sciences, Schmid College of Science and Technology, Chapman University, One University Drive, Orange, CA 92866, USA.
authors.forename: Keun-Hang Susan
authors.initials: KH
authors.lastname: Yang
authors.affiliation: Laboratory of Functional Lipidomics, Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
authors.forename: Sehamuddin
authors.initials: S
authors.lastname: Galadari
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D000081007:Cymenes; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology*; D007473:Ion Channels / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D039821:Monoterpenes / Q000737:chemistry / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000975:Antioxidants; D000081007:Cymenes; D007473:Ion Channels; D039821:Monoterpenes; C073316:carvacrol
keywords: Ligand-gated ion channels; Monoterpenes; TRP channels; Terpenes; Voltage-gated ion channels