title: The Relation between Duration of Ruptured Membranes and Perinatal Outcome in Patients with Midtrimester Prelabor Rupture of Membranes.
abstract: OBJECTIVE
  The aim of the study was to assess the impact of gestational age (GA) at rupture and latency on perinatal outcome after midtrimester prelabor rupture of membranes (PROM).
  
  
  METHODS
  We obtained data on singleton pregnancies from 22 weeks onwards from the Dutch Perinatal Registry from 1999 to 2007, congenital abnormalities were excluded. In women with PROM before 26 weeks, we studied the impact of GA at rupture and latency on perinatal mortality and morbidity.
  
  
  RESULTS
  A total of 1,233 pregnancies were included. Higher GA at delivery appeared to increase the probability of survival without morbidity, GA at PROM did not. In pregnancies of minimum 22 weeks GA, there appeared to be no clear relationship between earlier GA at PROM and adverse outcome.
  
  
  CONCLUSIONS
  Longer latency and early GA at PROM seem to have limited impact in patients delivering after 22 weeks.
authors.affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Augustinus
authors.initials: A
authors.lastname: van Teeffelen
authors.affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Jantien
authors.initials: J
authors.lastname: van der Heijden
authors.affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: David
authors.initials: D
authors.lastname: van der Ham
authors.affiliation: Department of Obstetrics and Gynecology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
authors.forename: Jelle M
authors.initials: JM
authors.lastname: Schaaf
authors.affiliation: Department of Epidemiology, Maastricht University Medical Center, The Netherlands.
authors.forename: Sander
authors.initials: S
authors.lastname: van Kuijk
authors.affiliation: Department of Medical Informatics, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Anita C J
authors.initials: AC
authors.lastname: Ravelli
authors.affiliation: Department of Obstetrics and Gynecology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
authors.forename: Eva
authors.initials: E
authors.lastname: Pajkrt
authors.affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Christine
authors.initials: C
authors.lastname: Willekes
authors.affiliation: Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Nijhuis
authors.affiliation: Department of Obstetrics and Gynecology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
authors.forename: Ben Willem M
authors.initials: BW
authors.lastname: Mol
mesh_terms: D000328:Adult; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands; D054238:Perinatal Mortality; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D018805:Sepsis / Q000453:epidemiology; D013997:Time Factors