title: Cobalt(II)/silver relay catalytic isocyanide insertion/cycloaddition cascades: a new access to pyrrolo[2,3-b]indoles.
abstract: The combination of Co(acac)2 and AgOTf enables the bimetallic relay catalysis reaction of 2-ethynylanilines and isocyanides, allowing easy and low-cost access to new densely functionalized pyrrolo[2,3-b]indoles. The reaction pathway involves a Co(acac)2-catalyzed double isocyanide insertion followed by a silver-enabled 1,3-dipolar cycloaddition. The synthetic utility of these bicycloaddition reactions results in subsequent C-C and C-N bond-forming events to rapidly build up molecular complexity.
authors.affiliation: Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou, 211116, P. R. China. wjhao@jsnu.edu.cn jiangchem@jsnu.edu.cn laotu@jsnu.edu.cn.
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Hao
authors.forename: Changsheng
authors.initials: C
authors.lastname: Yao
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
mesh_terms: D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry*; D061565:Cycloaddition Reaction; D007211:Indoles / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
chemical_list: D003486:Cyanides; D007211:Indoles; D003035:Cobalt; D012834:Silver