title: Thermal properties and morphology changes in degradation process of poly(L-lactide-co-glycolide) matrices with risperidone.
abstract: Determining thermal properties and morphology seems to be useful in the analysis of release and degradation processes form polymeric materials. Risperidone is available in the formulation of a long-acting injection based on poly(D,L-lactide-co-glycolide). Currently, alternative solutions are also offered, i.e., nano- and microparticles or implants, including copolymers of lactide and glycolide. The effect of risperidone content on the properties of poly(L-lactide-co-glycolide) matrices was determined. The study also involved an assessment of the changes during degradation. Risperidone free matrices and the matrices with risperidone were obtained by solvent casting. Thermal characteristics were tested by means of differential scanning calorimetry, and the morphology was evaluated using a scanning electron microscope. Risperidone did not change significantly semi-crystalline structure of poly(L-lactide-co-glycolide) matrices. The decrease in crystallization temperature and glass transition temperature during degradation was observed. Many pores and their deformation, the widening of pore area, cracks and slits because of degradation were observed. The analysis of thermal properties and morphology allowed us to explain degradation process. Matrices exhibited stable process of degradation, which may be advantageous for development of prolonged risperidone release systems.
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.|School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland, Chair and Department of Biopharmacy, Jedności 8, Sosnowiec, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Turek
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.|School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland, Chair and Department of Biopharmacy, Jedności 8, Sosnowiec, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Kasperczyk
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Jelonek
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Borecka
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
authors.forename: Henryk
authors.initials: H
authors.lastname: Janeczek
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Libera
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Gruchlik
authors.affiliation: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Dobrzyński
mesh_terms: D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers; D005898:Glass; D006358:Hot Temperature; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011098:Polyglactin 910 / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D018967:Risperidone / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013678:Technology, Pharmaceutical; D013816:Thermodynamics
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D012997:Solvents; D011098:Polyglactin 910; D018967:Risperidone