title: Development of Fe-based bulk metallic glasses as potential biomaterials.
abstract: A new series of Fe80-x-yCrxMoyP13C7 (x = 10, y = 10; x = 20, y = 5; x = 2 0, y = 10, all in at.%) bulk metallic glasses (BMGs) with the maximum diameter of 6mm have been developed for biomedical implant application by the combination method of fluxing treatment and J-quenching technique. The corrosion performance of the present Fe-based BMGs is investigated in both Hank's solution (pH = 7.4) and artificial saliva solution (pH = 6.3) at 37 °C by electrochemical measurements. The result indicates that the corrosion resistance of the present Fe-based BMGs in the above two simulated body solutions is much better than that of biomedical 316 L stainless steel (316 L SS), and approaching that of Ti6Al4V biomedical alloy (TC4). The concentrations of Fe, Ni and Cr ions released into the Hank's solution and artificial saliva solution from the present Fe-based BMGs after potentiodynamic polarization are significant lower than that released from 316 L SS. The biocompatibility of the present Fe-based BMGs is evaluated through the in vitro test of NIH3T3 cells culture in the present Fe-based BMG extraction media for 1, 3 and 5 days. The result indicates that the present Fe-based BMGs exhibit no cytotoxicity to NIH3T3 cells. And the test result of the cell adhesion and growth on the surface of the samples indicates that the present Fe-based BMGs exhibit the better cell viability compared with 316 L SS and TC4 biomedical alloys. The present Fe-based BMGs, especially Fe55Cr20Mo5P13C7 BMG, exhibit good glass formation ability, the high corrosion resistance and excellent biocompatibility, suggesting their promising potential as biomaterials.
authors.affiliation: School of Physics Science and Technology, Xinjiang University, Urumqi, Xinjiang 830046, People's Republic of China.
authors.forename: Shidan
authors.initials: S
authors.lastname: Li
authors.affiliation: First Affiliated Hospital of Xinjiang Medical University, Urumqi 830046, People's Republic of China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wei
authors.affiliation: School of Physics Science and Technology, Xinjiang University, Urumqi, Xinjiang 830046, People's Republic of China. Electronic address: qli@xju.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: First Affiliated Hospital of Xinjiang Medical University, Urumqi 830046, People's Republic of China. Electronic address: gaohan410@126.com.
authors.forename: Bingliang
authors.initials: B
authors.lastname: Jiang
authors.affiliation: First Affiliated Hospital of Xinjiang Medical University, Urumqi 830046, People's Republic of China.
authors.forename: You
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Physics Science and Technology, Xinjiang University, Urumqi, Xinjiang 830046, People's Republic of China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Sun
mesh_terms: D001572:Benzofurans / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D008422:Materials Testing; D046529:Microscopy, Electron, Transmission; D053761:Nanocomposites / Q000737:chemistry*; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D001572:Benzofurans; D001672:Biocompatible Materials; C073339:usnic acid
keywords: Biocompatibility; Biomaterials; Corrosion resistance; Fe-based bulk metallic glasses