title: The emerging role of CaMKII in cancer.
abstract: Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine kinases best known for its critical role in learning and memory. Recent studies suggested that high levels of CaMKII also expressed in variety of malignant diseases. In this review, we focus on the structure and biology properties of CaMKII, including the role of CaMKII in the regulation of cancer progression and therapy response. We also describe the role of CaMKII in the diagnosis of different kinds of cancer and recent progress in the development of CaMKII inhibitors. These data establishes CaMKII as a novel target whose modulation presents new opportunities for cancer diagnosis and treatment.
authors.affiliation: Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.|Cancer Institute, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Yan-yang
authors.initials: YY
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.|Cancer Institute, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Ren
authors.initials: R
authors.lastname: Zhao
authors.affiliation: Department of Radiation Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.|Cancer Institute, Ningxia Medical University, Yinchuan, Ningxia, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhe
mesh_terms: D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2
keywords: Ca2+/calmodulin-dependent protein kinase II (CaMKII); CaMKII inhibitor; cancer; cell cycle; therapeutic target