title: Autoinflammatory diseases: a possible cause of thrombosis?
abstract: Autoinflammatory diseases are a group of disorders due to acquired or hereditary disfunction of innate immune system and characterized by systemic or localized manifestations. The prototype is Familial Mediterranean Fever, a monogenic hereditary disorder, whose causing gene (MeFV gene) was identified in 1997 and opened the way to a new fascinanting chapter of rheumatology. A growing body of monogenic and poligenic autoinflammatory disorders has been described since then. Arterial and venous thrombosis is a common medical problem, with significant morbidity and mortality. Strong evidences from basic research and clinical epidemiological studies support the theory that inflammation and thrombosis can be associated. Because of their recurrent/chronic inflammatory nature, autoinflammatory diseases are a putative cause of thrombotic manifestations. In the present work, we reviewed the available evidences about monogenic autoinflammatory disorders, complicated by thrombotic manifestations.
authors.affiliation: Department of Internal Medicine, Ligurian East Hospital, La Spezia, Italy.
authors.forename: Micaela
authors.initials: M
authors.lastname: La Regina
authors.affiliation: Department of Internal Medicine, Ligurian East Hospital, La Spezia, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Orlandini
authors.affiliation: Centre of Periodic Fevers - Catholic University of Rome, Rome, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Manna
keywords: Arterial thrombosis; Autoinflammatory diseases; Criopyrinopathies; Familial mediterranean fever; Myocardial infarction; Periodic fevers; Pyrinopathies; Stroke; Venous thromboembolism; Venous thrombosis