title: Disrupted Balance of MMPs/TIMPs in Gastric Carcinogenesis-Paradoxical Low MMP-2 Expression in Tumor and Stromal Compartments as a Potential Marker of Unfavorable Outcome.
abstract: The aim of the study was to find correlations between MMP/TIMP reactivity and the expression of angiogenic factors, and relationships between these parameters and clinicopathological features of gastric cancer patients. Receiver Operating Characteristic curve analysis was used to find cut-off points that enabled fair decision-making in survival analysis. Low levels of MMP-2 expression in tumor and stromal compartments were significantly associated with poor prognosis-the probability that a patient would die within 60 months of surgery if their MMP-2 was low, and was about 0.8 in both neoplastic and stromal compartments.
authors.affiliation: 1Department of Pathomorphology and Oncological Cytology.
authors.forename: Piotr
authors.initials: P
authors.lastname: Donizy
authors.forename: Julia
authors.initials: J
authors.lastname: Rudno-Rudzinska
authors.forename: Maciej
authors.initials: M
authors.lastname: Kaczorowski
authors.forename: Jedrzej
authors.initials: J
authors.lastname: Kabarowski
authors.forename: Ewelina
authors.initials: E
authors.lastname: Frejlich
authors.forename: Wojciech
authors.initials: W
authors.lastname: Kielan
authors.forename: Rafal
authors.initials: R
authors.lastname: Matkowski
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Halon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042501:Angiogenic Proteins / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D008875:Middle Aged; D012372:ROC Curve; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D017154:Stromal Cells / Q000378:metabolism* / Q000473:pathology; D016019:Survival Analysis; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D042501:Angiogenic Proteins; D014408:Biomarkers, Tumor; D019714:Tissue Inhibitor of Metalloproteinases; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2
keywords: Biostatistics; Cancer biomarkers; Carcinogenesis; Stomach cancer