title: Refining the chemical toolbox to be fit for educational and practical purpose for drug discovery in the 21st Century.
abstract: We live in a time where exploration and generation of new knowledge is occurring on a colossal scale. Medicinal chemists have traditionally taken key roles in drug discovery; however, the many unmet medical demands in the healthcare sector emphasise the need to evolve the medicinal chemistry discipline. To rise to the challenges in the 21st Century there is a necessity to refine the chemical toolbox for educational and practical reasons. This review proposes modern strategies that are beneficial to teaching in academia but are also important reminders of strategies that can potentially lead to better drugs.
authors.affiliation: Department of Science and Drug Technology, University of Turin, Via Pietro Giuria, 9-10125 Turin, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Lolli
authors.affiliation: School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Narramore
authors.affiliation: School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.
authors.forename: Colin W G
authors.initials: CW
authors.lastname: Fishwick
authors.affiliation: Institute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, UK. Electronic address: k.pors1@bradford.ac.uk.
authors.forename: Klaus
authors.initials: K
authors.lastname: Pors
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000193:education* / Q000639:trends; D017076:Computer-Aided Design; D003479:Curriculum; D004059:Diffusion of Innovation; D015195:Drug Design; D055808:Drug Discovery / Q000193:education* / Q000639:trends; D004517:Education, Professional / Q000379:methods*; D005544:Forecasting; D049674:History, 21st Century; D006801:Humans; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry* / Q000378:metabolism; D010599:Pharmacokinetics; D021281:Quantitative Structure-Activity Relationship; D013663:Teaching / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations