title: Treatment with Iodine in Pregnant Rats with Marginal Iodine Deficiency Improves Cell Migration in the Developing Brain of the Progeny.
abstract: Marginal iodine deficiency is a common health problem in pregnant women. Epidemiological and animal studies had shown that marginally maternal iodine deficiency could cause the mild changes of maternal thyroid function, eventually lead to a negative effect on neurodevelopment. But the underlying mechanisms responsible for the neurological impairment remain unclear. The aim of this study is to explore whether marginally maternal iodine deficiency could produce subtle changes in cell migration and cognitive function of offspring, and the optimal time of giving intervention to minimize the adverse effects. In the present study, we established a marginal iodine deficiency model, and iodine supplement was performed on pre-pregnancy (PP), G13 (gestation day 13), and postnatal day 0 (P0). Our data showed that there were changes in the cytoarchitecture and the percentage of bromodeoxyuridine (BrdU)-labeled cells in the cerebral cortex in marginal iodine deficiency rats. The Reelin expression was significantly lower, but Tenascin-C was higher in the cerebral cortex of marginal iodine deficiency group on P7 than the normal group, respectively. When iodine supplement, especially before G13 could reverse the abnormal expression of the two proteins involved in cell migration, which was consistent with the results of Morris Water Maze test. The three intervention groups had shorter escape latencies than the marginal iodine deficiency rats. The earlier that iodine is supplied, the better behavior performance would reach. Our findings suggested that iodine supplement in early stage of pregnancy could improve the cell migration of cerebral cortex and neurodevelopment of offspring.
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medial University, No.155 Nanjing North Street, Shenyang, 110001, China.|The Second Department of Endocrinology, Sheng Jing Affiliated Hospital of China Medical University, Shenyang, 110000, China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
authors.affiliation: The Second Department of Endocrinology, Sheng Jing Affiliated Hospital of China Medical University, Shenyang, 110000, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Zhai
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medial University, No.155 Nanjing North Street, Shenyang, 110001, China.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medial University, No.155 Nanjing North Street, Shenyang, 110001, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medial University, No.155 Nanjing North Street, Shenyang, 110001, China. shanzhongyan@medmail.com.cn.
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Shan
authors.affiliation: Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medial University, No.155 Nanjing North Street, Shenyang, 110001, China. twp@vip.163.com.
authors.forename: Weiping
authors.initials: W
authors.lastname: Teng
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology* / Q000254:growth & development*; D001973:Bromodeoxyuridine / Q000378:metabolism; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D002465:Cell Movement / Q000187:drug effects*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000473:pathology; D007150:Immunohistochemistry; D007455:Iodine / Q000172:deficiency* / Q000494:pharmacology* / Q000652:urine; D018782:Maze Learning / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011247:Pregnancy; D017208:Rats, Wistar; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000378:metabolism; D013003:Somatosensory Cortex / Q000473:pathology; D019063:Tenascin / Q000378:metabolism; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717129:Reln protein, rat; D019063:Tenascin; D007455:Iodine; D012697:Serine Endopeptidases; D001973:Bromodeoxyuridine
keywords: Cell migration; Iodine supplement; Marginal iodine deficiency; Neurodevelopment