title: Resting state brain activity in patients with migraine: a magnetoencephalography study.
abstract: BACKGROUND
  Recent advances in migraine research have shown that the cerebral cortex serves a primary role in the pathogenesis of migraine. Since aberrant brain activity in migraine can be noninvasively detected with magnetoencephalography (MEG), The object of this study was to investigate the resting state cortical activity differences between migraineurs and controls and its related clinical characteristics.
  
  
  METHODS
  Twenty-two subjects with an acute migraine and twenty-two age- and gender-matched controls were studied using MEG. MEG recordings were recorded 120 seconds during the headache attack. Analyze MEG signals from low (1-4 Hz) to high (200-1000 Hz)-frequency ranges.
  
  
  RESULTS
  In comparison with the controls, brain activity in migraine subjects was significantly different from that of the controls both in two frequency ranges (55-90 Hz, p < 0.001) and (90-200 Hz, p < 0.004). But the power value showed no significantly differences between control and migraines in all frequency ranges (p > 0.05). All the clinical characteristics had no significant correlation with aberrant brain activity.
  
  
  CONCLUSIONS
  The results demonstrated that migraine subjects in resting state had significantly aberrant ictal brain activity that can be measured with neuromagnetic imaging techniques. The findings may facilitate the development of new therapeutic strategies in migraine treatment via alterations in cortical excitability with TMS and other medications in the future.
authors.affiliation: The Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Guang Zhou Road 264, Nanjing, Jiangsu, 210029, China, maclhx@yahoo.com.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Liu
authors.forename: Huaiting
authors.initials: H
authors.lastname: Ge
authors.forename: Jing
authors.initials: J
authors.lastname: Xiang
authors.forename: Ailiang
authors.initials: A
authors.lastname: Miao
authors.forename: Lu
authors.initials: L
authors.lastname: Tang
authors.forename: Ting
authors.initials: T
authors.lastname: Wu
authors.forename: Qiqi
authors.initials: Q
authors.lastname: Chen
authors.forename: Lu
authors.initials: L
authors.lastname: Yang
authors.forename: Xiaoshan
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008881:Migraine Disorders / Q000503:physiopathology*; D012146:Rest / Q000502:physiology*; D055815:Young Adult