title: Differential mobility spectrometry/mass spectrometry history, theory, design optimization, simulations, and applications.
abstract: This review of differential mobility spectrometry focuses primarily on mass spectrometry coupling, starting with the history of the development of this technique in the Soviet Union. Fundamental principles of the separation process are covered, in addition to efforts related to design optimization and advancements in computer simulations. The flexibility of differential mobility spectrometry design features is explored in detail, particularly with regards to separation capability, speed, and ion transmission. 2015 Wiley Periodicals, Inc. Mass Spec Rev 35:687-737, 2016.
authors.affiliation: AB SCIEX, Concord, ON, Canada, L4K 4V8. bradley.schneider@sciex.com.
authors.forename: Bradley B
authors.initials: BB
authors.lastname: Schneider
authors.affiliation: The Charles Stark Draper Laboratory, Tampa, FL 33612-9220.
authors.forename: Erkinjon G
authors.initials: EG
authors.lastname: Nazarov
authors.affiliation: AB SCIEX, Concord, ON, Canada, L4K 4V8.
authors.forename: Frank
authors.initials: F
authors.lastname: Londry
authors.affiliation: Department of Chemistry and Chemical Biology, Barnett Institute, Northeastern University, Boston, MA 02115.
authors.forename: Paul
authors.initials: P
authors.lastname: Vouros
authors.affiliation: AB SCIEX, Concord, ON, Canada, L4K 4V8.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Covey
mesh_terms: D003198:Computer Simulation; D013058:Mass Spectrometry; D013057:Spectrum Analysis
keywords: Differential mobility spectrometry; Mass spectrometry; ion