title: Synthetic studies of enacyloxins: a series of antibiotics isolated from Frateuria sp. W-315: C1'-C8' and C9'-C15' fragments.
abstract: Synthetic studies of enacyloxins (ENXs), a series of yellow-colored, polyene-polyol antibiotics produced by Frateuria sp. W-315, are described. The C1'-C8' polyene fragments were prepared using successive Wittig reactions. The C9'-C15' and C10'-C15' fragments were constructed from (S)-isopropylideneglyceraldehyde using Yamaguchi's nucleophilic substitution reaction of acetylide to epoxide, and/or Marshall's allenylindium mediated reaction as the key steps.
authors.forename: Aki
authors.initials: A
authors.lastname: Saito
authors.forename: Wataru
authors.initials: W
authors.lastname: Igarashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Furukawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hoshikawa
authors.forename: Teiko
authors.initials: T
authors.lastname: Yamada
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Kuwahara
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kiyota
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D020563:Gammaproteobacteria / Q000737:chemistry*; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D011090:Polyenes