title: Wound healing and longevity: lessons from long-lived αMUPA mice.
abstract: Does the longevity phenotype offer an advantage in wound healing (WH)? In an attempt to answer this question, we explored skin wound healing in the long-lived transgenic αMUPA mice, a unique model of genetically extended life span. These mice spontaneously eat less, preserve their body mass, are more resistant to spontaneous and induced tumorigenesis and live longer, thus greatly mimicking the effects of caloric restriction (CR). We found that αMUPA mice showed a much slower age-related decline in the rate of WH than their wild-type counterparts (FVB/N). After full closure of the wound, gene expression in the skin of old αMUPA mice returned close to basal levels. In contrast, old FVB/N mice still exhibited significant upregulation of genes associated with growth-promoting pathways, apoptosis and cell-cell/cell-extra cellular matrix interaction, indicating an ongoing tissue remodeling or an inability to properly shut down the repair process. It appears that the CR-like longevity phenotype is associated with more balanced and efficient WH mechanisms in old age, which could ensure a long-term survival advantage.
authors.affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
authors.forename: Hagai
authors.initials: H
authors.lastname: Yanai
authors.affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
authors.forename: Dimitri
authors.initials: D
authors.lastname: Toren
authors.affiliation: AIT - Austrian Institute of Technology, ATU14703506, Vienna, Austria.
authors.forename: Klemens
authors.initials: K
authors.lastname: Vierlinger
authors.affiliation: AIT - Austrian Institute of Technology, ATU14703506, Vienna, Austria.
authors.forename: Manuela
authors.initials: M
authors.lastname: Hofner
authors.affiliation: AIT - Austrian Institute of Technology, ATU14703506, Vienna, Austria.
authors.forename: Christa
authors.initials: C
authors.lastname: Nöhammer
authors.affiliation: Department of Pathology, University of Verona, Verona, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Chilosi
authors.affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
authors.forename: Arie
authors.initials: A
authors.lastname: Budovsky
authors.affiliation: The Shraga Segal Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.
authors.forename: Vadim E
authors.initials: VE
authors.lastname: Fraifeld
mesh_terms: D000367:Age Factors; D000818:Animals; D002465:Cell Movement; D005260:Female; D005347:Fibroblasts / Q000502:physiology; D015870:Gene Expression; D008136:Longevity; D008822:Mice, Transgenic; D012867:Skin / Q000473:pathology; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics* / Q000378:metabolism; D014945:Wound Healing
chemical_list: D014568:Urokinase-Type Plasminogen Activator
keywords: aging; caloric restriction; gene expression; growth-promoting pathways; wound healing; αMUPA mice