title: ADME SARfari: comparative genomics of drug metabolizing systems.
abstract: ADME SARfari is a freely available web resource that enables comparative analyses of drug-disposition genes. It does so by integrating a number of publicly available data sources, which have subsequently been used to build data mining services, predictive tools and visualizations for drug metabolism researchers. The data include the interactions of small molecules with ADME (absorption, distribution, metabolism and excretion) proteins responsible for the metabolism and transport of molecules; available pharmacokinetic (PK) data; protein sequences of ADME-related molecular targets for pre-clinical model species and human; alignments of the orthologues including information on known SNPs (Single Nucleotide Polymorphism) and information on the tissue distribution of these proteins. In addition, in silico models have been developed, which enable users to predict which ADME relevant protein targets a novel compound is likely to interact with.
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY and Pfizer Ltd., Granta Park, Great Abington, Cambridge CB21 6GP, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: Davies
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY and Pfizer Ltd., Granta Park, Great Abington, Cambridge CB21 6GP, UK.
authors.forename: Nathan
authors.initials: N
authors.lastname: Dedman
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY and Pfizer Ltd., Granta Park, Great Abington, Cambridge CB21 6GP, UK.
authors.forename: Anne
authors.initials: A
authors.lastname: Hersey
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY and Pfizer Ltd., Granta Park, Great Abington, Cambridge CB21 6GP, UK.
authors.forename: George
authors.initials: G
authors.lastname: Papadatos
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY and Pfizer Ltd., Granta Park, Great Abington, Cambridge CB21 6GP, UK.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Hall
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY and Pfizer Ltd., Granta Park, Great Abington, Cambridge CB21 6GP, UK.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Cucurull-Sanchez
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY and Pfizer Ltd., Granta Park, Great Abington, Cambridge CB21 6GP, UK.
authors.forename: Phil
authors.initials: P
authors.lastname: Jeffrey
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY and Pfizer Ltd., Granta Park, Great Abington, Cambridge CB21 6GP, UK.
authors.forename: Samiul
authors.initials: S
authors.lastname: Hasan
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY and Pfizer Ltd., Granta Park, Great Abington, Cambridge CB21 6GP, UK.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Eddershaw
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage SG1 2NY and Pfizer Ltd., Granta Park, Great Abington, Cambridge CB21 6GP, UK.
authors.forename: John P
authors.initials: JP
authors.lastname: Overington
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004285:Dogs; D023281:Genomics; D006801:Humans; D020407:Internet; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D012984:Software; D014018:Tissue Distribution
chemical_list: D011506:Proteins