title: [The French National Compound Library: advances and future prospects].
abstract: The French National Compound Library (Chimiothèque Nationale) has been created in 2003 and is the federation of local collections. It contains more than 56 000 small molecules and natural compounds synthesised or isolated in different laboratories over the past years. This explains the diversity of the collection. The strength of this initiative is the ability to connect chemists and biologists for the development of hits. This development involves the synthesis of analogues or/and chemical tools to find new targets. These collaborations lead to the identification of new chemical probes. These probes able to modulate a biological function are essential to study biological pathways. They can also be useful for therapeutic applications. This article will describe the major achievements and perspectives of the French Chemical Library.
authors.affiliation: Institut Curie, UMR 9187-U1196, bâtiment 110, Centre Universitaire, Chimie, modélisation moléculaire et imagerie pour la biologie, 91405 Orsay, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Mahuteau-Betzer
mesh_terms: D062126:Databases, Chemical / Q000592:standards / Q000600:supply & distribution / Q000639:trends; D004353:Drug Evaluation, Preclinical; D004346:Drug Information Services / Q000592:standards / Q000600:supply & distribution / Q000639:trends; D005602:France; D006801:Humans; D033181:Information Dissemination; D008968:Molecular Conformation; D054852:Small Molecule Libraries / Q000600:supply & distribution
chemical_list: D054852:Small Molecule Libraries