title: N-Heterocyclic carbene-catalyzed diastereoselective synthesis of β-lactone-fused cyclopentanes using homoenolate annulation reaction.
abstract: NHC-catalyzed annulation of enals with 2-enoylpyridines or 2-enoylpyridine N-oxides leading to the diastereoselective synthesis of β-lactone-fused cyclopentanes is reported. The reaction proceeds via the generation of homoenolate equivalent intermediates and tolerates a broad range of functional groups.
authors.affiliation: Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune-411008, India. at.biju@ncl.res.in.
authors.forename: Subrata
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Santigopal
authors.initials: S
authors.lastname: Mondal
authors.forename: Atanu
authors.initials: A
authors.lastname: Patra
authors.forename: Rajesh G
authors.initials: RG
authors.lastname: Gonnade
authors.forename: Akkattu T
authors.initials: AT
authors.lastname: Biju
mesh_terms: D002384:Catalysis; D003517:Cyclopentanes / Q000138:chemical synthesis*; D007783:Lactones / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*
chemical_list: D003517:Cyclopentanes; D007783:Lactones; D010087:Oxides; D011725:Pyridines; C030011:carbene; D008697:Methane