title: CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.
abstract: Although Th1 and Th2 cells are known to be involved in allergic inflammatory diseases, the molecular mechanisms underlying their differentiation are incompletely understood. In this study, we identified CD155 as a costimulatory molecule on CD4(+) T cells. Importantly, CD155-mediated signaling induced Th1 development in both humans and mice, as evidenced by production of IFN-γ and upregulation of Tbx21 transcription; these effects were independent of IL-12 but dependent on NF-κB-induced autocrine IFN-γ that triggered positive feedback via STAT1 activation. Mice genetically deficient in CD155 or treated with anti-CD155 Ab exhibited attenuated Th1-type contact hypersensitivity. Thus, CD155 plays an important regulatory role in helper T cell differentiation and allergic diseases.
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan;
authors.forename: Yumi
authors.initials: Y
authors.lastname: Yamashita-Kanemaru
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan;
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takahashi
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan;
authors.forename: Yinan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan; Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8575, Japan;
authors.forename: Satoko
authors.identifier: http://orcid.org/0000-0003-1958-4803
authors.initials: S
authors.lastname: Tahara-Hanaoka
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan;
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Honda
authors.affiliation: Institute of Immunology, Hannover Medical School, Hannover 30625, Germany; and.
authors.forename: Günter
authors.initials: G
authors.lastname: Bernhardt
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan; Life Science Center of Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305-8575, Japan; Japan Science and Technology Agency, Core Research for Evolutional Science and Technology, University of Tsukuba, Ibaraki 305-8575, Japan kazukos@md.tsukuba.ac.jp ashibuya@md.tsukuba.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Shibuya
authors.affiliation: Department of Immunology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan; kazukos@md.tsukuba.ac.jp ashibuya@md.tsukuba.ac.jp.
authors.forename: Kazuko
authors.initials: K
authors.lastname: Shibuya
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D003877:Dermatitis, Contact / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism*; D007371:Interferon-gamma / Q000378:metabolism; D018664:Interleukin-12 / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D010766:Phosphorylation; D011991:Receptors, Virus / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D011991:Receptors, Virus; C066100:poliovirus receptor; D018664:Interleukin-12; D007371:Interferon-gamma