title: Development of cup shaped microneedle array for transdermal drug delivery.
abstract: Microneedle technology is one of the attractive methods in transdermal drug delivery. However, the clinical applications of this method are limited owing to: complexity in the preparation of multiple coating solutions, drug leakage while inserting the microneedles into the skin and the outer walls of the solid microneedle can hold limited quantity of drug. Here, the authors present the fabrication of an array of rectangular cup shaped silicon microneedles, which provide for reduced drug leakage resulting in improvement of efficiency of drug delivery and possibility of introducing multiple drugs. The fabricated solid microneedles with rectangular cup shaped tip have a total height of 200 μm. These cup shaped tips have dimensions: 60 × 60 μm (length × breadth) with a depth of 60 μm. The cups are filled with drug using a novel in-house built drop coating system. Successful drug dissolution was observed when the coated microneedle was used on mice. Also, using the above method, it is possible to fill the cups selectively with different drugs, which enables simultaneous multiple drug delivery.
authors.affiliation: Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore 5600012, India and Department of Electronic Systems Engineering, Indian Institute of Science, Bangalore 5600012, India.
authors.forename: Kadayar B
authors.initials: KB
authors.lastname: Vinayakumar
authors.affiliation: Centre for Nano Science and Engineering, Indian Institute of Science, Bangalore 5600012, India.
authors.forename: Gopal M
authors.initials: GM
authors.lastname: Hegde
authors.affiliation: Central Animal Facility, Indian Institute of Science, Bangalore 5600012, India.
authors.forename: Subbaraya G
authors.initials: SG
authors.lastname: Ramachandra
authors.affiliation: Centre for Nano Science and Engineering, Indian Institute of Science, Bangalore 5600012, India.
authors.forename: Mangalore M
authors.initials: MM
authors.lastname: Nayak
authors.affiliation: Department of Electronic Systems Engineering, Indian Institute of Science, Bangalore 5600012, India.
authors.forename: Narasimhian S
authors.initials: NS
authors.lastname: Dinesh
authors.affiliation: Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore 5600012, India.
authors.forename: Konandur
authors.initials: K
authors.lastname: Rajanna
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D016503:Drug Delivery Systems / Q000295:instrumentation*; D005260:Female; D008819:Mice, Nude; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D012825:Silicon
chemical_list: D004364:Pharmaceutical Preparations; D012825:Silicon