title: Formulation and process optimization of naproxen nanosuspensions stabilized by hydroxy propyl methyl cellulose.
abstract: In present study precipitation-ultrasonication was used to obtain nanosuspensions of poorly water-soluble drug, naproxen (NPX). We investigated the effects of HPMC concentration (X1) and time of ultrasonication (X2) on imperative attributes like mean particle size (Y1), % drug content (Y2), and time required to 90% drug release (Y3) via 3(2) factorial design. The morphology of nanosuspensions was found almost spherical by SEM observation. DSC and XRD studies suggested slight crystalline change in drug. FT-IR revealed lack of significant interactions between NPX and HPMC. Nanosuspensions of mean particle size 530.55 nm was achieved. Dissolution rate obtained from all nanosuspensions were markedly higher than pure NPX. Response surface methodology and optimized polynomial equations were used to select optimal formulation i.e. 1.36%W/V of X1 and 13.9 min of X2 to get desired response Y1; 727.97 nm, Y2; 95.59% and Y3; 8.67 min that were in reasonable agreement with observed value.
authors.affiliation: Gayatri College of Pharmacy, Sambalpur, Odisha 768200, India. Electronic address: drbibaswanmishra@gmail.com.
authors.forename: Bibaswan
authors.initials: B
authors.lastname: Mishra
authors.affiliation: Shri Ram Murti Smarak College of Engg. and Technology (Pharmacy), Bareilly, U.P. 243202, India. Electronic address: drjagannathsahoo@gmail.com.
authors.forename: Jagannath
authors.initials: J
authors.lastname: Sahoo
authors.affiliation: Department of Zoology, Berhampur University, Ganjam, Odisha 760007, India. Electronic address: drdixit2001@gmail.com.
authors.forename: Prasanna Kumar
authors.initials: PK
authors.lastname: Dixit
mesh_terms: D065347:Hypromellose Derivatives / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009288:Naproxen / Q000737:chemistry*; D012995:Solubility; D013010:Sonication; D013535:Suspensions / Q000737:chemistry
chemical_list: D013535:Suspensions; D065347:Hypromellose Derivatives; D009288:Naproxen
keywords: HPMC; Nanosuspensions; Naproxen; Response surface methodology; Ultrasonication