title: NPR-A: A Therapeutic Target in Inflammation and Cancer.
abstract: Natriuretic peptide receptor A (NPR-A) is the receptor for atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). NPR-A plays critical physiological and pathophysiological roles in several target cell and tissue system processes, such as cell growth, apoptosis, proliferation, and inflammation. Accumulating data demonstrate that NPR-A is involved in immune and inflammatory reactions and is a potential target in inflammation treatment. It is expressed in various cancer cells and is important for tumor growth. A recent study indicated that NPR-A signaling can regulate stem cell recruitment and angiogenesis. This signaling can serve as a model for studying the linkage between inflammation and tumorigenesis. In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation.
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China; Department of Thoracic Surgery, the Nucleus Industry 215 Hospital, Xianyang, China.
authors.forename: Junhai
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Jingkun
authors.initials: J
authors.lastname: Qu
authors.affiliation: Department of Surgical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Wang
mesh_terms: D017209:Apoptosis / Q000235:genetics; D009320:Atrial Natriuretic Factor / Q000235:genetics / Q000378:metabolism; D063646:Carcinogenesis / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D020097:Natriuretic Peptide, Brain / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000473:pathology / Q000628:therapy; D017461:Receptors, Atrial Natriuretic Factor / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics
chemical_list: D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor; D017461:Receptors, Atrial Natriuretic Factor; C091715:atrial natriuretic factor receptor A