title: Calcium Channel Signaling Complexes with Receptors and Channels.
abstract: Voltage-gated calcium channels are not only mediators of cell signalling events, but also are recipients of signalling inputs from G protein coupled receptors (GPCRs) and their associated second messenger pathways. The coupling of GPCRs to calcium channels is optimized through the formation of receptor-channel complexes. In addition, this provides a mechanism for receptorchannel co-trafficking to and from the plasma membrane. On the other hand, voltage-gated calcium channel activity affects other types of ion channels such as voltage-and calcium-activated potassium channels. Coupling efficiency between these two families of channels is also enhanced through the formation of channel-channel complexes. This review provides a concise overview of the current state of knowledge on the physical interactions between voltage-gated calcium channels and members of the GPCR family, and with other types of ion channels.
authors.affiliation: Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Dr. NW, Calgary T2N 4N1, Canada. zamponi@ucalgary.ca.
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Zamponi
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D015221:Potassium Channels / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D015220:Calcium Channels; D015221:Potassium Channels