title: Large Deformation Properties of Red Blood Cell Membrane Based on a Higher Order Gradient Quasi-continuum Model.
abstract: Based on the proposed higher order gradient quasi-continuum model, the numerical investigations of the basic mechanical properties and deformation behaviors of human red blood cell (RBC) membrane under large deformation at room temperature (i.e., 300 K) are carried out in the present paper. The results show that RBC membrane is a nonlinear hyperelastic material. The mechanical properties of RBC membrane is dominated by isotropic nature at the stage of initial deformation, however, its anisotropic material properties emerge clearly with the loading increasing. The out-of-plane wrinkling of RBC membrane upon shear loading can be reproduced numerically. With the use of the so-called higher order Cauchy-Born rule as the kinematic description, the bending stiffness of RBC membrane can be considered conveniently.
authors.affiliation: School of Transportation, Ludong University, Yantai, Shandong, 264025, China. wxy017@126.com.
authors.forename: X Y
authors.initials: XY
authors.lastname: Wang
authors.affiliation: School of Shipping and Ports Architecture Engineering, Zhejiang Ocean University, Zhoushan, Zhejiang, 316022, China.
authors.forename: J B
authors.initials: JB
authors.lastname: Wang
authors.affiliation: Sheng'an Construction Group Co. Ltd, Zibo, Shandong, 255000, China.
authors.forename: B B
authors.initials: BB
authors.lastname: Qiu
authors.affiliation: School of Transportation, Ludong University, Yantai, Shandong, 264025, China.
authors.forename: L F
authors.initials: LF
authors.lastname: Hu
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000737:chemistry*; D006801:Humans; D008962:Models, Theoretical
keywords: Higher order Cauchy–Born rule; Meshless method; Quasi-continuum model; Red blood cell membrane; Spectrin network