title: Coalition of Nuclear Receptors in the Nervous System.
abstract: A universal signaling module has been described which utilizes the nuclear form of Fibroblast growth Factor Receptor 1 (FGFR1) in a central role directing the post-mitotic development of neural cells through coordinated gene expression. In this review, we discuss in detail the current knowledge of FGFR1 nuclear interaction partners in three scenarios: (i) Engagement of FGFR1 in neuronal stem cells and regulation of neuronal differentiation; (ii) interaction with the orphan receptor Nurr1 in development of mesencephalic dopaminergic neurons; (iii) modulation of nuclear FGFR1 interactions downstream of nerve growth factor (NGF) signaling. These coalitions demonstrate the versatility of non-canonical, nuclear tyrosine kinase signaling in diverse cellular differentiation programs of neurons.
authors.affiliation: Hannover Medical School, Department of Neuroanatomy, Hannover, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Förthmann
authors.affiliation: CH3 BioSystems LLC, New York State Center for Bioinformatics & Life Sciences, Buffalo, New York, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Aletta
authors.affiliation: Department of Pathology and Anatomical Sciences, Western New York Stem Cells Culture and Analysis Center, State University of New York, Buffalo, New York, USA.
authors.forename: Yu-Wei
authors.initials: YW
authors.lastname: Lee
authors.affiliation: Department of Pathology and Anatomical Sciences, Western New York Stem Cells Culture and Analysis Center, State University of New York, Buffalo, New York, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Terranova
authors.affiliation: Department of Pathology and Anatomical Sciences, Western New York Stem Cells Culture and Analysis Center, State University of New York, Buffalo, New York, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Birkaya
authors.affiliation: Department of Pathology and Anatomical Sciences, Western New York Stem Cells Culture and Analysis Center, State University of New York, Buffalo, New York, USA.
authors.forename: Ewa K
authors.initials: EK
authors.lastname: Stachowiak
authors.affiliation: Department of Pathology and Anatomical Sciences, Western New York Stem Cells Culture and Analysis Center, State University of New York, Buffalo, New York, USA.
authors.forename: Michal K
authors.initials: MK
authors.lastname: Stachowiak
authors.affiliation: Hannover Medical School, Department of Neuroanatomy, Hannover, Germany.|Center for Systems Neuroscience, Hannover, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Claus
mesh_terms: D000818:Animals; D059290:Dopaminergic Neurons / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D020932:Nerve Growth Factor / Q000378:metabolism; D009420:Nervous System / Q000166:cytology / Q000378:metabolism*; D058953:Neural Stem Cells / Q000378:metabolism*; D055495:Neurogenesis; D057126:Nuclear Receptor Subfamily 4, Group A, Member 2 / Q000378:metabolism; D020239:Receptor Cross-Talk; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D057126:Nuclear Receptor Subfamily 4, Group A, Member 2; D018160:Receptors, Cytoplasmic and Nuclear; D020932:Nerve Growth Factor; D051496:Receptor, Fibroblast Growth Factor, Type 1