title: Value of caffeic acid phenethyl ester pretreatment in experimental sepsis model in rats.
abstract: OBJECTIVE
  The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats.
  
  
  METHODS
  Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3), n = 8 each. CAPE was administered (10 µmol/kg) intraperitoneally to group 3 before sepsis induction. Serum ET-1, serum TNF-alpha, tissue SOD activity, and tissue MDA levels were measured in all groups.
  
  
  RESULTS
  Pretreatment with CAPE decreased ET-1, TNF-alpha, and MDA levels in sepsis induced rats. Additionally SOD activities were higher in rats pretreated with CAPE after sepsis induction.
  
  
  CONCLUSIONS
  Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. Therefore treatment with CAPE can be used to avoid devastating effects of sepsis.
authors.affiliation: Department of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey ; Department of Infectious Diseases and Clinical Bacteriology, Fatih Sultan Mehmet Training and Research Hospital, 34746 Istanbul, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Alici
authors.affiliation: Department of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey ; Department of Emergency Medicine, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: Havva Sahin
authors.initials: HS
authors.lastname: Kavakli
authors.affiliation: Department of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey ; Department of Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
authors.forename: Cemile
authors.initials: C
authors.lastname: Koca
authors.affiliation: Department of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey ; Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Neriman Defne
authors.initials: ND
authors.lastname: Altintas
authors.affiliation: Department of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey ; Department of Biochemistry, Faculty of Medicine, Namik Kemal University, Tekirdağ, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Aydin
authors.affiliation: Department of Infectious Diseases and Clinical Bacteriology and Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey ; Department of Oncology, Faculty of Medicine, Bahcesehir University, Istanbul, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Alici
mesh_terms: D000818:Animals; D002109:Caffeic Acids / Q000627:therapeutic use*; D004195:Disease Models, Animal; D019332:Endothelin-1 / Q000097:blood; D007249:Inflammation / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D010100:Oxygen / Q000737:chemistry; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018805:Sepsis / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D002109:Caffeic Acids; D019332:Endothelin-1; D017392:Thiobarbituric Acid Reactive Substances; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D013482:Superoxide Dismutase; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol; D010100:Oxygen