title: Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth.
abstract: A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneration-competent tissues and animals are able to prevent and counteract growth abnormalities and seem to have a low vulnerability to chemical carcinogenesis. Cancer cell survival depends, among other things, on various redox-related mechanisms, which are targets of currently developed therapies. Disadvantages of these therapies are a lack of specificity and drug resistance. As the majority of these redox-related mechanisms also play an important role in successful and coordinated cell functioning and reproduction, the regeneration process offers a unique parallel context for modern cancer research. This review focuses on the interconnections between regeneration and carcinogenesis and how an understanding of regenerative forces and redox-controlled mechanisms could contribute to the identification of new therapeutic targets to block the growth and survival of cancer cells.
authors.forename: An-Sofie
authors.initials: AS
authors.lastname: Stevens
authors.forename: Nicky
authors.initials: N
authors.lastname: Pirotte
authors.forename: Annelies
authors.initials: A
authors.lastname: Wouters
authors.forename: Andromeda
authors.initials: A
authors.lastname: Van Roten
authors.forename: Frank
authors.initials: F
authors.lastname: Van Belleghem
authors.forename: Maxime
authors.initials: M
authors.lastname: Willems
authors.forename: Ann
authors.initials: A
authors.lastname: Cuypers
authors.forename: Tom
authors.initials: T
authors.lastname: Artois
authors.affiliation: Zoology: Biodiversity and Toxicology, Centre for Environmental Sciences, Hasselt University, Agoralaan, building D, BE 3590 Diepenbeek, Belgium. karen.smeets@uhasselt.be.
authors.forename: Karen
authors.initials: K
authors.lastname: Smeets
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology*; D010084:Oxidation-Reduction; D012038:Regeneration / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents