title: Inhibition of soybean 15-lipoxygenase by naturally occurring acetophenones and derricidin.
abstract: Three selected naturally occurring oxyprenylated secondary metabolites, namely 2-hydroxy4-isopentenyloxyacetophenone (1), 4-geranyloxy-2-hydroxyacetophenone (2), 4-farnesyloxyacetophenone (3), and derricidin (4) were synthesized and their inhibitory potency against soybean 15-lipoxygenase evaluated. Compounds 1 and 4 showed the most potent inhibitory activity with ICo50 values of 2.5 µM and 0.6 µM.
authors.forename: Vito Alessandro
authors.initials: VA
authors.lastname: Taddeo
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
authors.forename: Serena
authors.initials: S
authors.lastname: Fiorito
mesh_terms: D000098:Acetophenones / Q000737:chemistry / Q000494:pharmacology*; D001093:Arachidonate 15-Lipoxygenase / Q000378:metabolism*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D013025:Glycine max / Q000201:enzymology*
chemical_list: D000098:Acetophenones; D005419:Flavonoids; D016859:Lipoxygenase Inhibitors; C000598623:derricidin; D001093:Arachidonate 15-Lipoxygenase