title: Vitamin D and atopic dermatitis in childhood.
abstract: Vitamin D features immunomodulatory effects on both the innate and adaptive immune systems, which may explain the growing evidence connecting vitamin D to allergic diseases. A wealth of studies describing a beneficial effect of vitamin D on atopic dermatitis (AD) prevalence and severity are known. However, observations linking high vitamin D levels to an increased risk of developing AD have also been published, effectively creating a controversy. In this paper, we review the existing literature on the association between AD and vitamin D levels, focusing on childhood. As of today, the role of vitamin D in AD is far from clear; additional studies are particularly needed in order to confirm the promising therapeutic role of vitamin D supplementation in childhood AD.
authors.affiliation: Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 11 Piazza Giulio Cesare, 70124 Bari, Italy.
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Vestita
authors.affiliation: Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 11 Piazza Giulio Cesare, 70124 Bari, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Filoni
authors.affiliation: Section of Dermatology, Vito Fazzi Hospital, Piazza Filippo Muratore, 73100 Lecce, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Congedo
authors.affiliation: Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 11 Piazza Giulio Cesare, 70124 Bari, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Foti
authors.affiliation: Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 11 Piazza Giulio Cesare, 70124 Bari, Italy.
authors.forename: Domenico
authors.identifier: 0000-0002-1319-4946
authors.initials: D
authors.lastname: Bonamonte
mesh_terms: D002648:Child; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology*; D019587:Dietary Supplements; D006370:Heliotherapy; D006801:Humans; D012306:Risk; D012867:Skin / Q000276:immunology / Q000473:pathology*; D019108:Tight Junctions / Q000276:immunology / Q000502:physiology; D014466:Ultraviolet Rays; D014807:Vitamin D / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use*
chemical_list: D014807:Vitamin D