title: Krill products: an overview of animal studies.
abstract: Many animal studies have been performed with krill oil (KO) and this review aims to summarize their findings and give insight into the mechanism of action of KO. Animal models that have been used in studies with KO include obesity, depression, myocardial infarction, chronic low-grade and ulcerative inflammation and are described in detail. Moreover, studies with KO in the form of krill powder (KP) and krill protein concentrate (KPC) as a mix of lipids and proteins are mentioned and compared to the effects of KO. In addition, differences in tissue uptake of the long-chain omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), when delivered in either phospholipid or triglyceride form, are addressed and the differential impact the delivery form has on gene expression profiles is explained. In our outlook, we try to highlight the potential of KO and KP supplementation in clinical settings and discuss health segments that have a high potential of showing krill product specific health benefits and warrant further clinical investigations.
authors.affiliation: Aker BioMarine Antarctic AS, Fjordalléen 16, NO-0115 Oslo, Norway. lena.burri@akerbiomarine.com.
authors.forename: Lena
authors.initials: L
authors.lastname: Burri
authors.affiliation: Aker BioMarine Antarctic AS, Fjordalléen 16, NO-0115 Oslo, Norway. line.johnsen@akerbiomarine.com.
authors.forename: Line
authors.initials: L
authors.lastname: Johnsen
mesh_terms: D000818:Animals; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects; D004041:Dietary Fats / Q000494:pharmacology* / Q000627:therapeutic use; D019587:Dietary Supplements; D033201:Euphausiacea / Q000737:chemistry*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology* / Q000627:therapeutic use; D015870:Gene Expression / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy; D050356:Lipid Metabolism / Q000187:drug effects; D009821:Oils / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D001688:Biological Products; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D009821:Oils