title: [Lamellar complex changes in the human basal forebrain and hypothalamic nuclei neurons in different age groups].
abstract: In the present study the lamellar complex (LC, Golgi complex) changes in the major cholinergic nuclei of the human basal forebrain - the nucleus basalis of Meynert (NBM), the vertical nucleus of the diagonal band of Broca (VDB) and hypothalamus--the tuberomamillary (TMN), the medial mammillary (MMN) and supraoptic (SON) nuclei were analyzed considering the WHO aging classification. The increase in the size of the LC was present in NBM, MMN and SON in the 3rd age group of elderly people (60-74 years of age), in the VDB--in the 4th group (75-89 years of age), whereas in the TMN LC changes were not apparent. In conclusion, the WHO aging classification reflects the LC values age ranges and can be used to estimate age-related alterations of this parameter. The increase in the size of the neuronal LC in elderly people may represent the compensatory reaction of neuroplasticity triggered by the aging process.
authors.forename: T A
authors.initials: TA
authors.lastname: Ishunina
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism / Q000473:pathology*; D066187:Basal Forebrain / Q000378:metabolism / Q000473:pathology*; D020532:Basal Nucleus of Meynert / Q000378:metabolism / Q000473:pathology*; D020667:Diagonal Band of Broca / Q000378:metabolism / Q000473:pathology*; D006056:Golgi Apparatus / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D011950:Receptors, Cholinergic / Q000378:metabolism
chemical_list: D011950:Receptors, Cholinergic