title: Helicobacter pylori infection in Chinese patients with atrial fibrillation.
abstract: OBJECTIVE
  To explore the relationship between Helicobacter pylori (Hp) infection and atrial fibrillation (AF) in Chinese patients.
  
  
  METHODS
  A total of 285 hospitalized patients with AF and 300 patients from Health Screening Center who matched age and sex with AF group were enrolled. AF patients were divided into two groups: the short-standing AF category (less than a year) and the long-standing AF category (more than a year). All patients had laboratory testing of (13)C urea breath test, high-sensitive C-reactive protein (hs-CRP) and left atrial diameter (LAD). We analyzed the difference of these factors in all groups and explored the correlation between Hp infection and AF using logistic regression analysis.
  
  
  RESULTS
  Both AF groups had more hypertension, diabetes, and Hp infection than the control group. The Hp value and the hs-CRP level in patients with long-standing AF were higher than those in the short-standing AF and the control groups (for Hp value: P<0.001 for both and for hs-CRP level: P=0.003, 0.002, respectively). The LAD of patients in the long-standing AF group was significantly larger than those in the short-standing AF group and control group (P=0.001 and P<0.001, respectively). The values of Hp, hs-CRP, and LAD in the long-standing AF category were significantly higher than those in the short-standing AF category (all P<0.05). After controlling the potential confounders, Hp value ≥4‰, hs-CRP >5 mg/L, and LAD >36 mm were significantly related to long-standing AF.
  
  
  CONCLUSIONS
  The values of Hp in patients with long-standing AF were significantly higher than those in short-standing AF and control groups. Hp δ value ≥4‰ is an independent predictor for long-standing AF.
authors.affiliation: Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: De-Zhao
authors.initials: DZ
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Ultrasonography, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Song
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Beijing Mentougou District Hospital, Beijing, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Ultrasonography, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Department of Cardiology, Beijing Mentougou District Hospital, Beijing, People's Republic of China.
authors.forename: Shi-Jing
authors.initials: SJ
authors.lastname: Li
authors.affiliation: Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Bu-Xing
authors.initials: BX
authors.lastname: Chen
mesh_terms: D044466:Asian People; D001281:Atrial Fibrillation / Q000453:epidemiology*; D001944:Breath Tests; D002097:C-Reactive Protein / Q000032:analysis; D002681:China / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D004452:Echocardiography; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D002097:C-Reactive Protein
keywords: 13C urea breath test; high sensitivity C-reactive protein; left atrial diameter