title: PharmGKB summary: Efavirenz pathway, pharmacokinetics.
authors.affiliation: Departments of aGenetics bBioengineering, School of Medicine, Stanford University, Stanford, California, USA cDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Ellen M
authors.initials: EM
authors.lastname: McDonagh
authors.forename: Johnathan L
authors.initials: JL
authors.lastname: Lau
authors.forename: Maria L
authors.initials: ML
authors.lastname: Alvarellos
authors.forename: Russ B
authors.initials: RB
authors.lastname: Altman
authors.forename: Teri E
authors.initials: TE
authors.lastname: Klein
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics / Q000378:metabolism; D000480:Alkynes; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D048588:Benzoxazines / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D003521:Cyclopropanes; D065637:Cytochrome P-450 CYP2A6 / Q000235:genetics / Q000378:metabolism; D065702:Cytochrome P-450 CYP2B6 / Q000235:genetics / Q000378:metabolism; D051544:Cytochrome P-450 CYP3A / Q000235:genetics / Q000378:metabolism; D004347:Drug Interactions; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D015497:HIV-1; D006801:Humans; D053858:Metabolic Networks and Pathways; D020641:Polymorphism, Single Nucleotide; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D018894:Reverse Transcriptase Inhibitors; C585710:CYP2A6 protein, human; C585599:CYP2B6 protein, human; C510164:CYP3A5 protein, human; D065637:Cytochrome P-450 CYP2A6; D065702:Cytochrome P-450 CYP2B6; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; C491474:UGT2B7 protein, human; D014453:Glucuronosyltransferase; C098320:efavirenz