title: A Comparison of Data Driven-based Measures of Adherence to Oral Hypoglycemic Agents in Medicaid Patients.
abstract: We evaluated and compared different methods for measuring adherence to Oral Antihyperglycemic Agents (OHA), based on the correlation between these measures and glycated hemoglobin A1C (HbA1c) levels in Medicaid patients with Type 2 diabetes. An observational sample of 831 Medicaid patients with Type 2 diabetes who had HbA1c test results recorded between January 1, 2001 and December 31, 2005 was identified in the Indiana Network of Patient Care (INPC). OHA adherence was measured by medication possession ratio (MPR), proportion of days covered (PDC), and the number of gaps (GAP) for 3, 6, and 12-month intervals prior to the HbA1c test date. All three OHA adherence measurements showed consistent and significant correlation with HbA1c level. The 6-month PDC showed the strongest association with HbA1c levels in both unadjusted (-1.07, P<0.0001) and adjusted (-1.12, P<0.0001) models.
authors.affiliation: Regenstrief Institute, IN.
authors.forename: Vivienne J
authors.initials: VJ
authors.lastname: Zhu
authors.affiliation: Regenstrief Institute, IN.
authors.forename: Wanzhu
authors.initials: W
authors.lastname: Tu
authors.affiliation: Regenstrief Institute, IN.
authors.forename: Marc B
authors.initials: MB
authors.lastname: Rosenman
authors.affiliation: Siemens Healthcare, Malvern, PA.
authors.forename: J Marc
authors.initials: JM
authors.lastname: Overhage
mesh_terms: D000284:Administration, Oral; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D006442:Glycated Hemoglobin / Q000032:analysis*; D066275:Health Information Exchange; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008484:Medicaid; D055118:Medication Adherence; D014481:United States
chemical_list: D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents