title: Management of venous thromboembolism in patients with acute leukemia at high bleeding risk: a multi-center study.
abstract: In the last decades, evaluation of clinically relevant thrombotic complications in patients with acute leukemia (AL) has been poorly investigated. The authors performed a multi-center study to evaluate the management of symptomatic venous thromboembolism (VTE) in adult patients with AL. The intention was to find as clinically relevant the following: symptomatic Venous Thrombosis (VT) occurred in typical (lower limbs) and atypical (cerebral, upper limbs, abdominal, etc) sites with or without pulmonary embolism (PE). Over a population of 1461 patients with AL, 22 cases of symptomatic VTE were recorded in hospitalized patients with a mean age of 54.6 years. The absolute incidence of VTE was 1.5%. VTE occurred during chemotherapy in 17/22 (77.2%) cases, mainly (14/17, 82.3%) during the induction phase. Treatment of acute VTE was based on Low Molecular Weight Heparin (LMWH) at full dosage for the first month from diagnosis and reduced dosage (75%) for the following months.
authors.affiliation: a Hematoloy Unit & Thrombosis and Hemostasis Reference Regional Center, University of Palermo , Palermo , Italy.
authors.forename: Mariasanta
authors.initials: M
authors.lastname: Napolitano
authors.affiliation: a Hematoloy Unit & Thrombosis and Hemostasis Reference Regional Center, University of Palermo , Palermo , Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Valore
authors.affiliation: b Hematology Unit, General Hospital "Cervello" , Palermo , Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Malato
authors.affiliation: a Hematoloy Unit & Thrombosis and Hemostasis Reference Regional Center, University of Palermo , Palermo , Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Saccullo
authors.affiliation: c Department of Clinical and Molecular BioMedicine Hematology Unit , University Hospital of Catania , Catania , Italy.
authors.forename: Calogero
authors.initials: C
authors.lastname: Vetro
authors.affiliation: a Hematoloy Unit & Thrombosis and Hemostasis Reference Regional Center, University of Palermo , Palermo , Italy.
authors.forename: Maria Enza
authors.initials: ME
authors.lastname: Mitra
authors.affiliation: b Hematology Unit, General Hospital "Cervello" , Palermo , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fabbiano
authors.affiliation: d Hematology Unit, "Papardo" General Hospital , Messina , Italy.
authors.forename: Donato
authors.initials: D
authors.lastname: Mannina
authors.affiliation: e Department of Health Promotion Sciences and Mother Child Care , University of Palermo , Palermo , Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Casuccio
authors.affiliation: f Hematology and Oncology Unit, Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori, IRCCS , Meldola , Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lucchesi
authors.affiliation: g Hematology Unit, "Tor Vergata" University Hospital , Roma , Italy.
authors.forename: Maria Ilaria
authors.initials: MI
authors.lastname: Del Principe
authors.affiliation: h Hematology Unit, Udine University Hospital , Udine , Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Candoni
authors.affiliation: c Department of Clinical and Molecular BioMedicine Hematology Unit , University Hospital of Catania , Catania , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Raimondo
authors.affiliation: a Hematoloy Unit & Thrombosis and Hemostasis Reference Regional Center, University of Palermo , Palermo , Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Siragusa
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019468:Disease Management; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D015994:Incidence; D007938:Leukemia / Q000150:complications* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D054556:Venous Thromboembolism / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology* / Q000628:therapy; D055815:Young Adult
keywords: Venous thrombosis; acute leukemia; low molecular weight heparin