title: Primary Central Nervous System Posttransplant Lymphoproliferative Disease in a Bilateral Transfemoral Lower Extremity Transplantation Recipient.
abstract: Posttransplant lymphoproliferative disorder (PTLD) is a heterogeneous group of clinical and pathological entities characterized by malignant lymphoid cell proliferation occurring after solid organ transplantation, with frequent extranodal involvement. Central nervous system (CNS) involvement occurs in 7-15% of the cases and it is a significant negative prognostic factor. A case of primary CNS (PCNS) PTLD in the first bilateral lower limb transplant recipient is presented.
authors.affiliation: Reconstructive Surgery Unit, Clinica Cavadas, Valencia, Spain.
authors.forename: P C
authors.initials: PC
authors.lastname: Cavadas
authors.affiliation: Reconstructive Surgery Unit, Clinica Cavadas, Valencia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Thione
authors.affiliation: Infectious Disease Unit, Hospital La Fe, Valencia, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Blanes
authors.affiliation: Anatomic Pathology Unit, Hospital La Fe, Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Mayordomo-Aranda
mesh_terms: D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007866:Leg / Q000637:transplantation*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis; D063986:Vascularized Composite Allotransplantation; D055815:Young Adult
keywords: Clinical research; practice; cancer; malignancy; neoplasia, clinical decision-making; vascularized composite and reconstructive transplantation