title: The photoelectrochemical exploration of multifunctional TiO2 mesocrystals and its enzyme-assisted biosensing application.
abstract: Mesocrystals, as the assemblies of crystallographically oriented nanocrystals, have single-crystal-like atom structures and scattering features but with much higher porosity than single-crystalline materials, making them promising substitutes for conventional single crystals in photoelectrochemical application. As a proof-of-concept, a series of photoelectrochemical tests were investigated to understand the influence of the differences between them on photoelectrochemical activity. Expectedly, comparing with TiO2 single crystals, TiO2 mesocrystals demonstrated higher photoelectrochemical capability, which provides unique new opportunities for materials design in the fields of solar-energy conversion and catalysis. Therefore, an elegant photoelectrochemical biosensing platform was firstly developed by virtue of carbon nanohorns with outstanding electrical conductivity support multifunctional TiO2 mesocrystals to accelerate the transfer of photogenerated electrons, and then horseradish peroxidase was introduced through the immune recognition reaction for enzyme-assisted in situ generating CdS QDs. The multiplex amplification strategy successfully achieved the ultrasensitive detection of α-fetoprotein antigen. Promisingly, the successful application of multiplex amplification strategy affords a rational and practical consideration for the fabrication of new and high-performance photoelectrochemical sensing devices.
authors.affiliation: College of Chemistry and Chemical Engineering, Fujian Normal University, Fujian, Fuzhou 350108, PR China. Electronic address: dhong@fjnu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Dai
authors.affiliation: College of Chemistry and Chemical Engineering, Fujian Normal University, Fujian, Fuzhou 350108, PR China.
authors.forename: Shupei
authors.initials: S
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Chemical Engineering, Fujian Normal University, Fujian, Fuzhou 350108, PR China.
authors.forename: Lingshan
authors.initials: L
authors.lastname: Gong
authors.affiliation: College of Chemistry and Chemical Engineering, Fujian Normal University, Fujian, Fuzhou 350108, PR China; Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials, College of Physics and Energy, Fujian Normal University, Fuzhou 350108, PR China.
authors.forename: Yilin
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Chemistry and Chemical Engineering, Fujian Normal University, Fujian, Fuzhou 350108, PR China.
authors.forename: Guifang
authors.initials: G
authors.lastname: Xu
authors.affiliation: College of Chemistry and Chemical Engineering, Fujian Normal University, Fujian, Fuzhou 350108, PR China; Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, and Department of Chemistry, Fuzhou University, Fuzhou 350002, PR China.
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Lin
authors.affiliation: Fujian Provincial Key Laboratory of Quantum Manipulation and New Energy Materials, College of Physics and Energy, Fujian Normal University, Fuzhou 350108, PR China. Electronic address: winter0514@163.com.
authors.forename: Zhensheng
authors.initials: Z
authors.lastname: Hong
mesh_terms: D055910:Antibodies, Immobilized / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods; D019187:Cadmium Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D057230:Limit of Detection; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D055668:Photochemical Processes; D045663:Quantum Dots / Q000737:chemistry / Q000648:ultrastructure; D013440:Sulfides / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D055910:Antibodies, Immobilized; D019187:Cadmium Compounds; D013440:Sulfides; D000509:alpha-Fetoproteins; C034939:cadmium sulfide; C009495:titanium dioxide; D002244:Carbon; D014025:Titanium
keywords: Carbon nanohorns; Enzyme-assisted; Photoelectrochemical; TiO(2) mesocrystals