title: DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis.
abstract: Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies have been conflicting. To clarify the role of DNMT3A polymorphisms in cancer, we conducted a meta-analysis of 2014 cases and 3089 control subjects. Odds ratios with 95% confidence intervals were estimated to evaluate the association between the DNMT3A -448A>G polymorphism and cancer risk. The results showed that DNMT3A may be a protective factor against all cancer types and colorectal cancer groups. Further studies should be conducted including different ethnicities and large population sizes to generate a comprehensive conclusion.
authors.affiliation: Medical School of Southeast University, Nanjing, China.
authors.forename: C H
authors.initials: CH
authors.lastname: Liu
authors.affiliation: Medical School of Southeast University, Nanjing, China.
authors.forename: T
authors.initials: T
authors.lastname: Tao
authors.affiliation: Medical School of Southeast University, Nanjing, China.
authors.forename: L
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: B
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
authors.forename: K
authors.initials: K
authors.lastname: Lu
authors.affiliation: Medical School of Southeast University, Nanjing, China.
authors.forename: X W
authors.initials: XW
authors.lastname: Zhang
authors.affiliation: Medical School of Southeast University, Nanjing, China.
authors.forename: S Q
authors.initials: SQ
authors.lastname: Chen
authors.affiliation: Medical School of Southeast University, Nanjing, China.
authors.forename: D C
authors.initials: DC
authors.lastname: Liu
authors.affiliation: Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China mingchenseu@126.com.
authors.forename: M
authors.initials: M
authors.lastname: Chen
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D000090205:DNA Methyltransferase 3A; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D009369:Neoplasms / Q000145:classification / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C000717967:DNMT3A protein, human; D004248:DNA (Cytosine-5-)-Methyltransferases; D000090205:DNA Methyltransferase 3A