title: Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depression in a Patient With an Intracranial Space-Occupying Lesion: A Case Report of Safety.
abstract: This is the first case report of the safety of therapeutic repetitive transcranial magnetic stimulation (rTMS) in a patient with an intracranial space-occupying lesion who had recurrent major depression. In this case, the intracranial space-occupying lesion was a mixed cystic and solid enhancing pineal region mass measuring approximately 16.9 × 12.2 × 15.5 mm. The patient remitted from depression with 36 sessions of dorsolateral prefrontal cortex rTMS treatments over a 6-week period. During the rTMS treatment course, patient's medication list included bupropion that potentially can increase the risk for a seizure and topiramate that potentially can reduce the risk for seizure associated with the treatment. The patient tolerated the rTMS treatment well, reporting only transient headache and discomfort at the site of stimulation after the treatment. She tolerated the procedure well and had no incidental seizure activity throughout her treatment sessions.
authors.affiliation: From the Department of Psychiatry and Health Behavior, Medical College of Georgia, Georgia Regents University, Augusta, GA.
authors.forename: Sandarsh
authors.initials: S
authors.lastname: Surya
authors.forename: Peter B
authors.initials: PB
authors.lastname: Rosenquist
authors.forename: W Vaughn
authors.initials: WV
authors.lastname: McCall
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D016642:Bupropion / Q000009:adverse effects / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000150:complications* / Q000628:therapy*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010871:Pinealoma / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D012008:Recurrence; D000077236:Topiramate; D050781:Transcranial Magnetic Stimulation / Q000379:methods*
chemical_list: D000927:Anticonvulsants; D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D000077236:Topiramate; D005632:Fructose