title: Melanotic oncocytic metaplasia of the nasopharynx: a case report with a focus on immunohistochemical analyses and literature review.
abstract: Melanotic oncocytic metaplasia (MOM) of the nasopharynx is an extremely rare lesion, with only 21 cases reported in English literature to date. MOM typically occurs near the Eustachian tube opening in Asian men in their 60 s to 70 s. Here, we present a case of MOM in a 57-year-old Japanese man who is a heavy smoker. The patient did not have complaints; MOM was diagnosed incidentally as 4 flat elevated lesions with brown to black discoloration, ranging from 2 to 3 mm in maximal diameter, were found in the right torus tubarius. On suspecting melanoma, the largest lesion was biopsied. Microscopic examination identified both oncocytic metaplasia and melanin pigmentation of the epithelium in the same gland. Upon immunohistochemical examination, melanocytes displayed reactivity for 3 out of 4 melanocytic markers; immunopositivity for S-100 protein, Melan-A, and MITF and immunonegativity for HMB-45 was observed. Normal melanocytes in the nearby surface respiratory epithelium displayed the same pattern of immunoreactivity. Immunopositivity for S-100 protein and immunonegativity for HMB-45 have been previously reported in MOM. Reduction of stimulation of melanocytes in a longstanding lesion like MOM may explain the immunonegativity for HMB-45. S-100 protein, in conjunction with more specific marker for melanocytes, Melan-A or MITF, could prove the definite presence of melanocytes in this case of MOM. As it has been shown by previous reports that MOM pursues a benign course, it will be sufficient to follow up the patients regularly for the remaining 3 lesions.
authors.affiliation: Department of Pathology, Graduate School of Medicine, The University of Tokyo Tokyo, Japan ; Department of Pathology, Fujieda Municipal General Hospital Shizuoka, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Tajima
authors.affiliation: Department of Otolaryngology, Fujieda Municipal General Hospital Shizuoka, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Ohkubo
authors.affiliation: Department of Otolaryngology, Fujieda Municipal General Hospital Shizuoka, Japan.
authors.forename: Matsumi
authors.initials: M
authors.lastname: Yoshida
authors.affiliation: Department of Pathology, Fujieda Municipal General Hospital Shizuoka, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Koda
authors.affiliation: Department of Otolaryngology, Fujieda Municipal General Hospital Shizuoka, Japan.
authors.forename: Ichirota
authors.initials: I
authors.lastname: Nameki
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000378:metabolism / Q000473:pathology*; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D008679:Metaplasia / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009302:Nasopharyngeal Diseases / Q000378:metabolism / Q000473:pathology*; D009305:Nasopharynx / Q000378:metabolism / Q000473:pathology*
keywords: Melanotic oncocytic metaplasia; immunohistochemistry; nasopharynx