title: Finite element implementation of a multiscale model of the human lens capsule.
abstract: An axisymmetric finite element implementation of a previously described structural constitutive model for the human lens capsule (Burd in Biomech Model Mechanobiol 8(3):217-231, 2009) is presented. This constitutive model is based on a hyperelastic approach in which the network of collagen IV within the capsule is represented by an irregular hexagonal planar network of hyperelastic bars, embedded in a hyperelastic matrix. The paper gives a detailed specification of the model and the periodic boundary conditions adopted for the network component. Momentum balance equations for the network are derived in variational form. These balance equations are used to develop a nonlinear solution scheme to enable the equilibrium configuration of the network to be computed. The constitutive model is implemented within a macroscopic finite element framework to give a multiscale model of the lens capsule. The possibility of capsule wrinkling is included in the formulation. To achieve this implementation, values of the first and second derivatives of the strain energy density with respect to the in-plane stretch ratios need to be computed at the local, constitutive model, level. Procedures to determine these strain energy derivatives at equilibrium configurations of the network are described. The multiscale model is calibrated against previously published experimental data on isolated inflation and uniaxial stretching of ex vivo human capsule samples. Two independent example lens capsule inflation analyses are presented.
authors.affiliation: Department of Engineering Science, Oxford University, Oxford, UK. harvey.burd@eng.ox.ac.uk.
authors.forename: H J
authors.initials: HJ
authors.lastname: Burd
authors.affiliation: Department of Civil, Environmental, and Architectural Engineering, University of Colorado Boulder, Boulder, CO, USA. richard.regueiro@colorado.edu.
authors.forename: R A
authors.initials: RA
authors.lastname: Regueiro
mesh_terms: D024141:Collagen Type IV / Q000502:physiology*; D003198:Computer Simulation; D055119:Elastic Modulus / Q000502:physiology; D020342:Finite Element Analysis; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000502:physiology*; D008954:Models, Biological; D013314:Stress, Mechanical; D013718:Tensile Strength / Q000502:physiology
chemical_list: D024141:Collagen Type IV
keywords: Accommodation; Collagen; Human lens capsule; Multiscale