title: Association between BDNF gene polymorphisms and attention deficit hyperactivity disorder in Korean children.
abstract: BACKGROUND
  Attention deficit hyperactivity disorder (ADHD) is a common childhood neuropsychiatric disorder characterized by behavioral problems such as attention deficit, hyperactivity, and impulsivity. The brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the brain.
  
  
  OBJECTIVE
  The aim of the present study was to investigate the association between the genotype and alleles for the BDNF gene in Korean children with ADHD.
  
  
  METHODS
  The sample consisted of 180 ADHD children and 159 control children. We diagnosed ADHD according to the DSM-IV. ADHD symptoms were evaluated with Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 339 subjects, DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for BDNF rs6265, rs11030101, rs10835210, rs7103873, and rs2030324 polymorphisms. Alleles and genotype frequencies were compared using the Chi-square test. We compared the allele and genotype frequencies of the BDNF gene polymorphism in the ADHD and control groups.
  
  
  RESULTS
  This study showed that there was a significant correlation among the allele frequencies of the rs11030101 and rs10835210 single nucleotide polymorphisms (SNPs) (odds ratio=0.61, 95% confidence interval=0.39-0.96, p=0.034), but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggest that the BDNF allelic structure may impact ADHD symptoms.
authors.affiliation: 1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea .|2 Department of Preventive Medicine, College of Medicine, Dankook University , Cheonan, South Korea .
authors.forename: Ho Jang
authors.initials: HJ
authors.lastname: Kwon
authors.affiliation: 1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea .|2 Department of Preventive Medicine, College of Medicine, Dankook University , Cheonan, South Korea .
authors.forename: Mina
authors.initials: M
authors.lastname: Ha
authors.affiliation: 1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea .|3 Department of Nanobiotics, College of Natural Science, Dankook University , Cheonan, South Korea .
authors.forename: Han Jun
authors.initials: HJ
authors.lastname: Jin
authors.affiliation: 4 Department of Rehabilitation Medicine, College of Medicine, Dankook University , Cheonan, South Korea .|5 Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University , Cheonan, South Korea .
authors.forename: Jung Keun
authors.initials: JK
authors.lastname: Hyun
authors.affiliation: 6 Department of Psychiatry, College of Medicine, Soonchunhyang University , Cheonan, South Korea .
authors.forename: Se Hoon
authors.initials: SH
authors.lastname: Shim
authors.affiliation: 1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea .|7 Department of Psychiatry, College of Medicine, Dankook University , Cheonan, South Korea .
authors.forename: Ki Chung
authors.initials: KC
authors.lastname: Paik
authors.affiliation: 8 Department of Pediatrics, College of Medicine, Dankook University , Cheonan, South Korea .
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Park
authors.affiliation: 1 Environmental Health Center, Dankook Medical Hospital , Cheonan, South Korea .|9 Department of Psychology, College of Public Welfare, Dankook University , Cheonan, South Korea .
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Lim
mesh_terms: D044466:Asian People; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D011795:Surveys and Questionnaires
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human