title: Forces of Change: Mechanics Underlying Formation of Functional 3D Organ Buds.
abstract: 3D organ buds that can recapitulate organ function have myriad applications for regenerative and personalized medicine. Here, Takebe et al. (2015) describe a generalized method for organ bud formation, demonstrating that mechanosensitive mesenchymal stem cells drive condensation of heterotypic cell mixtures to create buds from diverse organs.
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53792, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Wrighton
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53792, USA; Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53792, USA. Electronic address: kiessling@chem.wisc.edu.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Kiessling
mesh_terms: D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D010179:Pancreas / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*