title: Catalytic Enantioselective Reaction of α-Phenylthioacetonitriles with Imines Using Chiral Bis(imidazoline)-Palladium Catalysts.
abstract: The catalytic enantioselective reaction of α-phenylthioacetonitriles with imines has been developed. The reaction of various imines proceeds in good yields and diastereo- and enantioselectivities in the presence of chiral bis(imidazoline)-palladium catalysts. The obtained products can be converted into β-aminonitrile or β-aminoamide compounds without loss of enantiopurity.
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555 (Japan), Fax: (+81) 52-735-5245.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kondo
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555 (Japan), Fax: (+81) 52-735-5245.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Kobayashi
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan).
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Hatanaka
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan).
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Funahashi
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555 (Japan), Fax: (+81) 52-735-5245. snakamur@nitech.ac.jp.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Nakamura
keywords: asymmetric catalysis; imidazoline; nitriles; palladium; pincer-type complexes