title: Estrogen suppresses melatonin-enhanced hyperactivation of hamster spermatozoa.
abstract: Hamster sperm hyperactivation is enhanced by progesterone, and this progesterone-enhanced hyperactivation is suppressed by 17β-estradiol (17βE2) and γ-aminobutyric acid (GABA). Although it has been indicated that melatonin also enhances hyperactivation, it is unknown whether melatonin-enhanced hyperactivation is also suppressed by 17βE2 and GABA. In the present study, melatonin-enhanced hyperactivation was significantly suppressed by 17βE2 but not by GABA. Moreover, suppression of melatonin-enhanced hyperactivation by 17βE2 occurred through non-genomic regulation via the estrogen receptor (ER). These results suggest that enhancement of hyperactivation is regulated by melatonin and 17βE2 through non-genomic regulation.
authors.affiliation: Department of Physiology, Dokkyo Medical University, Tochigi 321-0293, Japan.
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Fujinoki
authors.forename: Gen L
authors.initials: GL
authors.lastname: Takei
mesh_terms: D000818:Animals; D004958:Estradiol / Q000737:chemistry / Q000378:metabolism*; D004965:Estrogen Antagonists; D005260:Female; D007700:Kinetics; D008297:Male; D008550:Melatonin / Q000819:agonists / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008647:Mesocricetus; D008954:Models, Biological; D013075:Sperm Capacitation / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013629:Tamoxifen / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D004965:Estrogen Antagonists; D013629:Tamoxifen; D004958:Estradiol; D005680:gamma-Aminobutyric Acid; D008550:Melatonin