title: Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats.
abstract: We investigated the effects of Hericium erinaceus (HEE) on alloxan induced diabetic neuropathic pain in laboratory rats. Alloxan induced diabetic rats were administered orally HEE. After 6 weeks of treatments, treatment with HEE 40 mg/kg in diabetic animals showed significant increase in pain threshold and paw withdrawal threshold and significant decrease in serum glucose and urine glucose. We also observed a significant increase in lactate dehydrogenase (LDH), Lipid peroxidation (LPO), glutathione peroxidase (GPx) activity, glutathione reductase (GR) activity, catalase (CAT) activity, Na(+)K(+)ATPase activity, and glutathione S transferase (GST) activity along with significant decreased levels of glutathione (GSH) content in diabetic rats. The total antioxidant status (TAOS) in the HEE-treated groups was significantly lower than that in the alloxan-treated group. HEE can offer pain relief in diabetic neuropathic pain. The improvement in diabetic state after HEE treatment along with the antioxidant activity could be the probable way by which it had alleviated diabetic neuropathy.
authors.affiliation: Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yi
authors.affiliation: Department of Pathology, Zhengzhou Railway Vocational and Technical College, Zhengzhou, Henan 450000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shao-Long
authors.affiliation: Department of Endocrinology, 306 Hospital of PLA, Beijing 100101, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Ai-Hong
authors.affiliation: Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, China.
authors.forename: Sun
authors.initials: S
authors.lastname: Zhi-Chun
authors.affiliation: Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, China.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Ya-Fen
authors.affiliation: Endocrine and Metabolic Diseases Division, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Ye-Ting
authors.affiliation: Endocrine and Metabolic Diseases Division, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors.forename: He
authors.initials: H
authors.lastname: Yu-Ling