title: [IFITM, a common barrier to many viruses].
abstract: During evolution, organisms developed adaptative mechanisms to survive continuous aggressions from a variety of pathogens. Among these lines of defence, many cellular proteins have been described to modulate viral replication and are the subject of intense study. This review will focus on IFITM (interferon induced transmembrane protein), a family of proteins that act against a particularly wide range of viruses. We will summarize our knowledge of the antiviral mechanisms used by IFITM to interfere with the replication of several viruses, and more specifically HIV (human immunodeficiency virus).
authors.affiliation: CIRI (centre international de recherche en infectiologie), 69364 Lyon, France - Inserm U1111, 46, allée d'Italie, 69364 Lyon, France - École normale supérieure de Lyon, 46, allée d'Italie, 69364 Lyon, France - CNRS, UMR5308, 46, allée d'Italie, 69364 Lyon, France - Université de Lyon, Lyon I, UMS3444/US8 BioSciences Gerland, 69364 Lyon, France.
authors.forename: Kevin
authors.initials: K
authors.lastname: Tartour
authors.affiliation: CIRI (centre international de recherche en infectiologie), 69364 Lyon, France - Inserm U1111, 46, allée d'Italie, 69364 Lyon, France - École normale supérieure de Lyon, 46, allée d'Italie, 69364 Lyon, France - CNRS, UMR5308, 46, allée d'Italie, 69364 Lyon, France - Université de Lyon, Lyon I, UMS3444/US8 BioSciences Gerland, 69364 Lyon, France.
authors.forename: Andrea
authors.initials: A
authors.lastname: Cimarelli
mesh_terms: D000818:Animals; D000943:Antigens, Differentiation / Q000502:physiology; D000998:Antiviral Agents / Q000378:metabolism; D015497:HIV-1 / Q000276:immunology / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D008565:Membrane Proteins / Q000502:physiology*; D021381:Protein Transport; D014780:Viruses / Q000276:immunology*
chemical_list: D000943:Antigens, Differentiation; D000998:Antiviral Agents; D008565:Membrane Proteins; C062010:leu-13 antigen