title: Novel roles of the unfolded protein response in the control of tumor development and aggressiveness.
abstract: The hallmarks of cancer currently define the molecular mechanisms responsible for conferring specific tumor phenotypes. Recently, these characteristics were also connected to the status of the secretory pathway, thereby linking the functionality of this cellular machinery to the acquisition of cancer cell features. The secretory pathway ensures the biogenesis of proteins that are membrane-bound or secreted into the extracellular milieu and can control its own homeostasis through an adaptive signaling pathway named the unfolded protein response (UPR). In the present review, we discuss the specific features of the UPR in various tumor types and the impact of the selective activation of this pathway on cell transformation, tumor development and aggressiveness.
authors.affiliation: INSERM, UMR-1053, Team "Endoplasmic Reticulum Stress and Cancer", 33000 Bordeaux, France; Université de Bordeaux, 33000 Bordeaux, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dejeans
authors.affiliation: INSERM, UMR-1053, Team "Endoplasmic Reticulum Stress and Cancer", 33000 Bordeaux, France; Université de Bordeaux, 33000 Bordeaux, France; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA; ER440 Université Rennes 1, "Oncogenesis, Stress, Signaling", Rennes, France; Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France.
authors.forename: Kim
authors.initials: K
authors.lastname: Barroso
authors.affiliation: Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Fernandez-Zapico
authors.affiliation: Apoptosis Research Centre, School of Natural Sciences, NUI Galway, Galway, Ireland.
authors.forename: Afshin
authors.initials: A
authors.lastname: Samali
authors.affiliation: INSERM, UMR-1053, Team "Endoplasmic Reticulum Stress and Cancer", 33000 Bordeaux, France; Université de Bordeaux, 33000 Bordeaux, France; ER440 Université Rennes 1, "Oncogenesis, Stress, Signaling", Rennes, France; Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France. Electronic address: eric.chevet@inserm.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Chevet
mesh_terms: D000818:Animals; D017209:Apoptosis; D002462:Cell Membrane / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D058750:Epithelial-Mesenchymal Transition; D005770:Gastrointestinal Neoplasms / Q000473:pathology; D006706:Homeostasis; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D010641:Phenotype; D015398:Signal Transduction; D056811:Unfolded Protein Response
keywords: Cancer; EMT; Endoplasmic reticulum; Stress; Tumor