title: The potential of sestrins as therapeutic targets for diabetes.
abstract: Sestrins (Sesn1/2/3) belong to a small protein family that has versatile biological functions. In addition to initially characterized oxidoreductase activity, sestrins also have oxidoreductase-independent functions, including activation of AMP-activated protein kinase, inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) and activation of mTORC2. As these kinases are important for metabolic regulation, sestrins have a favorable profile as potential therapeutic targets for metabolic diseases such as diabetes. Recent data are in line with such a notion. In this editorial, I have attempted to provide a brief update on the major findings in regard to sestrins in metabolism.
authors.affiliation: Indiana University School of Medicine, Department of Biochemistry and Molecular Biology , IN 46202 , USA xcdong@iu.edu.
authors.forename: Xiaocheng Charlie
authors.initials: XC
authors.lastname: Dong
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000503:physiopathology; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D009687:Nuclear Proteins / Q000378:metabolism*; D000084622:Sestrins
chemical_list: D006360:Heat-Shock Proteins; D009687:Nuclear Proteins; C117338:SESN1 protein, human; D000084622:Sestrins; C465398:SESN2 protein, human; C485523:SESN3 protein, human
keywords: mechanistic target of rapamycin complex 1; mechanistic target of rapamycin complex 2; sestrin; v-akt murine thymoma viral oncogene homolog