title: The relationship between cannabidiol and psychosis: A review.
abstract: BACKGROUND
  Cannabis sativa is the most widely used illicit drug in the world. There is concern about its harmful effects, especially because of increasing potency, which has been reported globally. These effects seem to result from the relationship among its components, notably delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), which have opposite effects. THC is considered responsible for the main psychotropic effects of the drug, while CBD seems to antagonize these effects, particularly those that induce psychosis.
  
  
  METHODS
  We performed a PubMed literature review of research discussing the association of cannabidiol and psychosis published from 2006 to July 2014.
  
  
  RESULTS
  The effects of Cannabis seem to depend on several variables related to the type of plant, its strength, usage patterns, and intersubjective variations. CBD could be used to treat several conditions, including psychosis, when the current treatment is associated with significant side effects.
  
  
  CONCLUSIONS
  Because of the complexity of the subject, including limitations and contradictions in studies available to date, further research involving the possible antipsychotic effect and other potential positive effects of Cannabis are needed. There also are noteworthy differences between the research design parameters and recreational use of Cannabis.
authors.affiliation: Department of Health, State University of Southwestern Bahia, Jequié, Bahia, Brazil. E-MAIL: thaybgs@hotmail.com.
authors.forename: Thayanne Brandão Guimarães
authors.initials: TB
authors.lastname: Silva
authors.forename: Cássio Queiroz
authors.initials: CQ
authors.lastname: Balbino
authors.forename: Anderson Fábio Moura
authors.initials: AF
authors.lastname: Weiber
mesh_terms: D002185:Cannabidiol / Q000494:pharmacology*; D006801:Humans; D011618:Psychotic Disorders / Q000188:drug therapy*
chemical_list: D002185:Cannabidiol