title: Platelet rich fibrin combined with decalcified freeze-dried bone allograft for the treatment of human intrabony periodontal defects: a randomized split mouth clinical trail.
abstract: OBJECTIVE
  Polypeptide growth factors of platelet rich fibrin (PRF) have the potential to regenerate periodontal tissues. Osteoinductive property of demineralized freeze-dried bone allograft (DFDBA) has been successfully utilized in periodontal regeneration. The aim of the present randomized, split mouth, clinical trial was to determine the additive effects of PRF with a DFDBA in the treatment of human intrabony periodontal defects.
  
  
  METHODS
  Sixty interproximal infrabony defects in 30 healthy, non-smoker patients diagnosed with chronic periodontitis were randomly assigned to PRF/DFDBA group or the DFDBA/saline. Clinical [pocket depth (PD), clinical attachment level (CAL) and gingival recession (REC)] and radiographic (bone fill, defect resolution and alveolar crest resorption) measurements were made at baseline and at a 12-month evaluation.
  
  
  RESULTS
  Compared with baseline, 12-month results indicated that both treatment modalities resulted in significant changes in all clinical and radiographic parameters. However, the PRP/DFDBA group exhibited statistically significantly greater changes compared with the DFDBA/saline group in PD (4.15 ± 0.84 vs 3.60 ± 0.51 mm), CAL (3.73 ± 0.74 vs 2.61 ± 0.68 mm), REC (0.47 ± 0.56 vs 1.00 ± 0.61 mm), bone fill (3.50 ± 0.67 vs 2.49 ± 0.64 mm) and defect resolution (3.73 ± 0.63 vs 2.75 ± 0.57 mm).
  
  
  CONCLUSIONS
  Observations indicate that a combination of PRF and DFDBA is more effective than DFDBA with saline for the treatment of infrabony periodontal defects.
authors.affiliation: a 1 Deparment of Periodontics, Institute of Dental Sciences , Bareilly, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Agarwal
authors.affiliation: b 2 Department of Periodontics, Dr. Z. A. Dental College , Aligarh, India.
authors.forename: Narinder Dev
authors.initials: ND
authors.lastname: Gupta
authors.affiliation: a 1 Deparment of Periodontics, Institute of Dental Sciences , Bareilly, India.
authors.forename: Avikal
authors.initials: A
authors.lastname: Jain
mesh_terms: D064591:Allografts / Q000637:transplantation*; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D001792:Blood Platelets / Q000502:physiology*; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D055113:Chronic Periodontitis / Q000601:surgery; D004311:Double-Blind Method; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005612:Freeze Drying; D005889:Gingival Recession / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D011859:Radiography; D014021:Tissue Preservation / Q000379:methods; D016896:Treatment Outcome
chemical_list: D005337:Fibrin
keywords: Chronic periodontitis; intrabony defect; periodontal regeneration; platelet rich fibrin