title: T cells, mast cells and microvascular density in diffuse large B cell lymphoma.
abstract: Diffuse large B cell lymphoma (DLBCL) is recognized as the most common form of non-Hodgkin lymphoma (NHL), accounting for about 40 % of all cases of NHL. Among the cellular components of the tumor inflammatory infiltrate, T cells and mast cells have been demonstrated to be correlated with tumor angiogenesis. In this report, we have investigated CD3 and tryptase expression and their relationship with microvascular density (MVD) in DLBCL patients. Moreover, we determined the significance of CD3 expression in bulky and non-bulky disease. CD3 expression was significantly lower in bulky disease patients when compared to non-bulky ones. CD3 showed a positive correlation with tryptase and MVD, while multiple regression analysis efficaciously predicted MVD depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in DLBCL patients.
authors.affiliation: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Marinaccio
authors.affiliation: Department of Emergency and Transplantation, Pathology Section, University of Bari Medical School, Bari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ingravallo
authors.affiliation: Department of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Bari, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Gaudio
authors.affiliation: Department of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Bari, Italy.
authors.forename: Tommasina
authors.initials: T
authors.lastname: Perrone
authors.affiliation: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Ruggieri
authors.affiliation: Department of Emergency and Transplantation, Pathology Section, University of Bari Medical School, Bari, Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Opinto
authors.affiliation: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Nico
authors.affiliation: Department of Emergency and Transplantation, Pathology Section, University of Bari Medical School, Bari, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Maiorano
authors.affiliation: Department of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Bari, Italy.
authors.forename: Giorgina
authors.initials: G
authors.lastname: Specchia
authors.affiliation: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Piazza Giulio Cesare, 11, 70124, Bari, Italy. domenico.ribatti@uniba.it.|National Cancer Institute "Giovanni Paolo II", Bari, Italy. domenico.ribatti@uniba.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis*; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008297:Male; D008407:Mast Cells / Q000737:chemistry*; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000737:chemistry*; D053802:Tryptases / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D017252:CD3 Complex; D053802:Tryptases
keywords: Angiogenesis; Diffuse large B cell lymphoma; Mast cells; Microvascular density; T cells