title: Erlotinib in non-small cell lung cancer's second line treatment. Clinical case.
abstract: Male, of 58 years, caucasian, construction worker, non smoker, with depressive syndrome, biliary lithiasis, renal cysts, surgery for benign intestinal polyps and relevant familiar history - aunt with lung cancer and mother with colon cancer. He initiated thorax pain and vomitting and made a chest x-ray, showing a right basal lung mass. During the etiologic study, he was submitted to thoracotomy with biopsy, in April 2006 - "fine granulations, spread for all the pulmonary field", allowing the diagnosis - adenosquamous lung carcinoma, stage IV (16/05/2006). He initiated citostatic treatment with vinorelbine-carboplatin in 02/06/2006, with haematological toxicity and later with neurological toxicity. At that time, he passed to second line treatment with erlotinib, that it was initiated in 11/06/2007, without significant secondary effects. Patient developed trigemic nerve pain, in October/2007, which subsequent study disclosed right esfenopetroclival meningioma, treated with radiosurgery. Later he presented cerebral metastization and erlotinib was discontinued in 09/06/2008. He was submitted to neuroradiosurgery. Now is under symptom support care. Rev Port Pneumol 2008; XIV (Supl 3): S79-S82.
authors.affiliation: Interna Complementar, Serviço de Medicina Interna 1 - Unidade de Oncologia Médica, Hospital Infante D. Pedro - Aveiro - Portugal.
authors.forename: Mariana
authors.initials: M
authors.lastname: Sousa
authors.affiliation: Assistente Hospitalar de Medicina Interna, Serviço de Medicina Interna 1 - Unidade de Oncologia Médica, Hospital Infante D. Pedro - Aveiro - Portugal.
authors.forename: Susana
authors.initials: S
authors.lastname: Cavadas
authors.affiliation: Assistente Hospitalar de Medicina Interna, Serviço de Medicina Interna 1 - Unidade de Oncologia Médica, Hospital Infante D. Pedro - Aveiro - Portugal.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Moreira
authors.affiliation: Assistente Hospitalar de Oncologia Médica, Serviço de Medicina Interna 1 - Unidade de Oncologia Médica, Hospital Infante D. Pedro - Aveiro - Portugal.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Mellidez
keywords: Lung cancer; Neoplasia do pulmão; adenosquamous carcinoma; carboplatin; carboplatino; carcinoma adenoescamoso; erlotinib; vinorelbina; vinorelbine