title: Non-hormonal treatment of vulvo-vaginal atrophy-related symptoms in post-menopausal women.
abstract: In post-menopausal period vulvo-vaginal atrophy (VVA)-related symptoms may seriously affect women's quality of life. Hormonal replacement therapy effectively relieves these symptoms but it is not always safe or accepted, and a non-hormonal treatment is often needed instead. Over a period of 12 weeks, we tested the effect of a twice-a-week vulvo-vaginal application of a hyaluronic acid, AC collagen, isoflavones and vitamins-based cream (Perilei Pausa) on 35 women in post-menopausal period, reporting VVA-related symptoms. After 12 weeks of treatment with Perilei Pausa a significant improvement in vaginal dryness, vulvo-vaginal itching, dyspareunia (P < 0.001), dysuria (P = 0.02), nocturia (P = 0.009) and pollakiuria (P = 0.005) was reported by the women. Colposcopical score assessing the intensity of atrophic colpitis, cervico-vaginal paleness and petechiae was also reduced (P = 0.037, P = 0.016 and P = 0.032, respectively). No significant difference in terms of maturation value of cervico-vaginal epithelium was observed. In conclusion, Perilei Pausa may represent an effective and safe alternative treatment of symptomatic VVA in post-menopausal women.
authors.affiliation: a Department of Obstetrics and Gynecology , Policlinico A. Gemelli, Università Cattolica Del Sacro Cuore , Rome , Italy.
authors.forename: C
authors.initials: C
authors.lastname: Tersigni
authors.affiliation: a Department of Obstetrics and Gynecology , Policlinico A. Gemelli, Università Cattolica Del Sacro Cuore , Rome , Italy.
authors.forename: N
authors.initials: N
authors.lastname: Di Simone
authors.affiliation: a Department of Obstetrics and Gynecology , Policlinico A. Gemelli, Università Cattolica Del Sacro Cuore , Rome , Italy.
authors.forename: E
authors.initials: E
authors.lastname: Tempestilli
authors.affiliation: b Institute of Human Pathology, Policlinico A. Gemelli, Università Cattolica Del Sacro Cuore , Rome , Italy.
authors.forename: F
authors.initials: F
authors.lastname: Cianfrini
authors.affiliation: b Institute of Human Pathology, Policlinico A. Gemelli, Università Cattolica Del Sacro Cuore , Rome , Italy.
authors.forename: R
authors.initials: R
authors.lastname: Russo
authors.affiliation: a Department of Obstetrics and Gynecology , Policlinico A. Gemelli, Università Cattolica Del Sacro Cuore , Rome , Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Moruzzi
authors.affiliation: a Department of Obstetrics and Gynecology , Policlinico A. Gemelli, Università Cattolica Del Sacro Cuore , Rome , Italy.
authors.forename: I D
authors.initials: ID
authors.lastname: Amar
authors.affiliation: a Department of Obstetrics and Gynecology , Policlinico A. Gemelli, Università Cattolica Del Sacro Cuore , Rome , Italy.
authors.forename: A
authors.initials: A
authors.lastname: Fiorelli
authors.affiliation: a Department of Obstetrics and Gynecology , Policlinico A. Gemelli, Università Cattolica Del Sacro Cuore , Rome , Italy.
authors.forename: G
authors.initials: G
authors.lastname: Scambia
authors.affiliation: a Department of Obstetrics and Gynecology , Policlinico A. Gemelli, Università Cattolica Del Sacro Cuore , Rome , Italy.
authors.forename: P
authors.initials: P
authors.lastname: Villa
mesh_terms: D000368:Aged; D001284:Atrophy / Q000188:drug therapy; D003127:Colposcopy; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D014621:Vagina / Q000187:drug effects* / Q000473:pathology; D014622:Vaginal Creams, Foams, and Jellies / Q000494:pharmacology / Q000627:therapeutic use*; D014623:Vaginal Diseases / Q000188:drug therapy*; D014845:Vulvar Diseases / Q000188:drug therapy*
chemical_list: D014622:Vaginal Creams, Foams, and Jellies
keywords: collagen; dyspareunia; hyaluronic acid; isoflavones; vulvo-vaginal atrophy