title: Surface plasmon resonance: a versatile technique for biosensor applications.
abstract: Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and without the need of labels. This review article discusses a wide range of applications in optical-based sensors using either surface plasmon resonance (SPR) or surface plasmon resonance imaging (SPRI). Here we summarize the principles, provide examples, and illustrate the utility of SPR and SPRI through example applications from the biomedical, proteomics, genomics and bioengineering fields. In addition, SPR signal amplification strategies and surface functionalization are covered in the review.
authors.affiliation: BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea. hhiep86@kribb.re.kr.|Department of Nanobiotechnology, Korea University of Science and Technology (UST), Daejeon 305-350, Korea. hhiep86@kribb.re.kr.
authors.forename: Hoang Hiep
authors.initials: HH
authors.lastname: Nguyen
authors.affiliation: BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea. jayho88@kribb.re.kr.|Department of Nanobiotechnology, Korea University of Science and Technology (UST), Daejeon 305-350, Korea. jayho88@kribb.re.kr.
authors.forename: Jeho
authors.initials: J
authors.lastname: Park
authors.affiliation: Department of Biological Sciences, School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea. sabsab7@unist.ac.kr.
authors.forename: Sebyung
authors.initials: S
authors.lastname: Kang
authors.affiliation: BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Korea. kimm@kribb.re.kr.|Department of Nanobiotechnology, Korea University of Science and Technology (UST), Daejeon 305-350, Korea. kimm@kribb.re.kr.|Department of Pathobiology, College of Veterinary Medicine Nursing & Allied Health (CVMNAH), Tuskegee University, Tuskegee, AL 36088, USA. kimm@kribb.re.kr.
authors.forename: Moonil
authors.initials: M
authors.lastname: Kim
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D020349:Surface Plasmon Resonance / Q000379:methods*