title: The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients.
abstract: BACKGROUND
  Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS).
  
  
  METHODS
  We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients. Genotyping of the rs599839, rs646776, and rs4970834 polymorphisms was performed on Arab patients undergoing coronary angiography for ACS. Patients were divided into group A (ACS with insignificant stenosis (<50%)) and group B (with significant stenosis (≥ 50%)).
  
  
  RESULTS
  Patients carrying the minor G allele in rs599839 had significantly lower mean of LDL-C (2.58 versus 3.44 mM, P = 0.026) than homozygous A allele carriers (GG versus AA). Carriers of minor C allele in rs64776 had significantly higher mean of HDL-C (2.16 versus 1.36 mM, P = 0.004) than carriers of the T alleles (AA versus GG). The odd ratio and 95% confidence interval for dominant model for G allele carriers of rs599839 were 0.51 (0.30-0.92), P = 0.038, among patients with significant stenosis.
  
  
  CONCLUSIONS
  Polymorphisms rs646776 and rs599839 of locus 1p13.3 were significantly associated with LDL-C and other lipid parameters. In addition, the G-allele carriers of variant rs599839 had a significant protective effect against the atherosclerosis.
authors.affiliation: Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar.
authors.forename: Nasser M
authors.initials: NM
authors.lastname: Rizk
authors.affiliation: Cardiology Unit, Ahmed Maher Teaching Hospital, Cairo, Egypt ; Clinical Medicine, Weill Cornell Medical School, P.O. Box 24144, Doha, Qatar.
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Menyar
authors.affiliation: Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar.
authors.forename: Huda
authors.identifier: 0000-0003-0760-0570
authors.initials: H
authors.lastname: Egue
authors.affiliation: Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar.
authors.forename: Idil
authors.identifier: 0000-0002-2022-631X
authors.initials: I
authors.lastname: Souleman Wais
authors.affiliation: Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar.
authors.forename: Hissa
authors.initials: H
authors.lastname: Mohamed Baluli
authors.affiliation: Health Sciences Department, CAS, Qatar University, P.O. Box 2713, Doha, Qatar.
authors.forename: Khalid
authors.initials: K
authors.lastname: Alali
authors.affiliation: Cardiology Unit, Al-Emadi Hospital, P.O. Box 5804, Doha, Qatar.
authors.forename: Fathi
authors.initials: F
authors.lastname: Farag
authors.affiliation: Clinical Chemistry Department, Hamad Medical Corporation (HMC), P.O. Box 3050, Doha, Qatar.
authors.forename: Noura
authors.identifier: 0000-0001-5694-8763
authors.initials: N
authors.lastname: Younes
authors.affiliation: Cardiology Department, Heart Hospital, Hamad Medical Corporation (HMC), P.O. Box 3050, Doha, Qatar.
authors.forename: Jassim
authors.initials: J
authors.lastname: Al Suwaidi
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D008078:Cholesterol, LDL / Q000097:blood / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics* / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood / Q000235:genetics*; D005260:Female; D056426:Genetic Loci; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D008078:Cholesterol, LDL