title: Effects of dietary trans-9 octadecenoic acid, trans-11 vaccenic acid and cis-9, trans-11 conjugated linoleic acid in mice.
abstract: The aim of the present study was to investigate the effects of dietary trans fatty acids in mice. Following the administration of a 0.5/100 g diet of trans-9 octadecenoic acid (EA), trans-11 vaccenic acid (TVA) or cis-9, trans-11 conjugated linoleic acid (CLA) for 4 weeks, the body weights and the weights of the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually decreased (P<0.05). The EA group exhibited the lowest levels of magnesium and triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group exhibited the lowest levels of low-density lipoprotein and tumor necrosis factor-α (P<0.05). Taken together, EA, TVA and CLA affected the physiological conditions of mice differently. The potential effects of three well-known fatty acids, including trans-9 octadecenoic acid (EA), trans-11 vaccenic acid (TVA) and cis-9, trans-11 conjugated linoleic acid (CLA), in animals or humans remain to be elucidated. Therefore, in the present study, 32 animals were randomly divided into four groups and administered a 0.5/100 g diet of EA, TVA or CLA for 4 weeks. The results demonstrated that the body weights and the weights of the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually decreased (P<0.05). Blood was collected individually via the external jugular veins and the EA group exhibited the lowest levels of magnesium and triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group exhibited the lowest levels of low-density lipoprotein and tumor necrosis factor-α (P<0.05). Taken together, EA, TVA and CLA affected the physiological conditions of mice differently and these may further our understanding of the various effects of these fatty acids on animals and humans.
authors.affiliation: Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
authors.forename: Ji-Na
authors.initials: JN
authors.lastname: Lim
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
authors.forename: Sang-Bum
authors.initials: SB
authors.lastname: Lee
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
authors.forename: Jin-Hee
authors.initials: JH
authors.lastname: Hwang
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
authors.forename: U-Suk
authors.initials: US
authors.lastname: Jung
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Biomaterials Science, College of Natural Resources and Life Science, Pusan National University, Miryang, Gyeongnam 627‑706, Republic of Korea.
authors.forename: Dae-Youn
authors.initials: DY
authors.lastname: Hwang
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
authors.forename: Sang-Rak
authors.initials: SR
authors.lastname: Lee
authors.affiliation: Lab of Animal Physiology, Graduate School of Agriculture Science, Tohoku University, Sendai, Miyagi 988‑8555, Japan.
authors.forename: Sang-Gun
authors.initials: SG
authors.lastname: Roh
authors.affiliation: Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, Republic of Korea.
authors.forename: Hong-Gu
authors.initials: HG
authors.lastname: Lee
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004041:Dietary Fats / Q000008:administration & dosage*; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008482:Mediastinum; D051379:Mice; D008813:Mice, Inbred ICR; D019301:Oleic Acid / Q000008:administration & dosage*; D009829:Oleic Acids / Q000008:administration & dosage*; D013737:Testis / Q000187:drug effects / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D004041:Dietary Fats; D044243:Linoleic Acids, Conjugated; D008077:Lipoproteins, LDL; D009829:Oleic Acids; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; C503589:cis-9, trans-11-conjugated linoleic acid; D019301:Oleic Acid; C050413:11-octadecenoic acid