title: Diastereodivergent Catalytic Asymmetric Michael Addition of 2-Oxindoles to α,β-Unsaturated Ketones by Chiral Diamine Catalysts.
abstract: A diastereodivergent catalytic asymmetric Michael addition of 2-oxindoles to α,β-unsaturated ketones has been successfully developed with two complementary chiral diamine catalysts, affording chiral 3,3-disubstituted oxindoles with two adjacent chiral centers. Diastereodivergence has been realized through modifying substrates and utilizing different catalysts. Either anti-or syn-configured products possessing vicinal quaternary and tertiary stereogenic centers were produced with high enantioselectivities.
authors.affiliation: †Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy and ‡Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wei
authors.affiliation: †Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy and ‡Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Shigang
authors.initials: S
authors.lastname: Wen
authors.affiliation: †Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy and ‡Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Zunwu
authors.initials: Z
authors.lastname: Liu
authors.affiliation: †Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy and ‡Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Wu
authors.affiliation: †Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy and ‡Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Bubing
authors.initials: B
authors.lastname: Zeng
authors.affiliation: †Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, School of Pharmacy and ‡Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Jinxing
authors.initials: J
authors.lastname: Ye
mesh_terms: D003959:Diamines / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: D003959:Diamines; D007211:Indoles; D007659:Ketones; D000078183:Oxindoles; C022960:2-oxindole