title: A genome scan for candidate genes involved in the adaptation of turbot (Scophthalmus maximus).
abstract: Partitioning phenotypic variance in genotypic and environmental variance may benefit from the population genomic assignment of genes putatively involved in adaptation. We analyzed a total of 256 markers (120 microsatellites and 136 Single Nucleotide Polymorphisms - SNPs), several of them associated to Quantitative Trait Loci (QTL) for growth and resistance to pathologies, with the aim to identify potential adaptive variation in turbot Scophthalmus maximus L. The study area in the Northeastern Atlantic Ocean, from Iberian Peninsula to the Baltic Sea, involves a gradual change in temperature and an abrupt change in salinity conditions. We detected 27 candidate loci putatively under selection. At least four of the five SNPs identified as outliers are located within genes coding for ribosomal proteins or directly related with the production of cellular proteins. One of the detected outliers, previously identified as part of a QTL for growth, is a microsatellite linked to a gene coding for a growth factor receptor. A similar set of outliers was detected when natural populations were compared with a sample subjected to strong artificial selection for growth along four generations. The observed association between FST outliers and growth-related QTL supports the hypothesis of changes in growth as an adaptation to differences in temperature and salinity conditions. However, further work is needed to confirm this hypothesis.
authors.affiliation: Departamento de Genética, Universidad de Santiago de Compostela, Facultad de Biología, Santiago de Compostela E-15706, Spain. Electronic address: roman.vilas@usc.es.
authors.forename: Román
authors.initials: R
authors.lastname: Vilas
authors.affiliation: University of Leuven, Laboratory of Biodiversity and Evolutionary Genomics, Charles Deberiotstraat 32, B-3000 Leuven, Belgium. Electronic address: sara.vandamme@ilvo.vlaanderen.be.
authors.forename: Sara G
authors.initials: SG
authors.lastname: Vandamme
authors.affiliation: Departamento de Genética, Universidad de Santiago de Compostela, Facultad de Veterinaria, Lugo E-27002, Spain. Electronic address: manuel.verar@udg.edu.
authors.forename: Manuel
authors.initials: M
authors.lastname: Vera
authors.affiliation: Departamento de Genética, Universidad de Santiago de Compostela, Facultad de Veterinaria, Lugo E-27002, Spain. Electronic address: mcarmen.bouza@usc.es.
authors.forename: Carmen
authors.initials: C
authors.lastname: Bouza
authors.affiliation: University of Leuven, Laboratory of Biodiversity and Evolutionary Genomics, Charles Deberiotstraat 32, B-3000 Leuven, Belgium; Centre for Sustainable Tropical Fisheries and Aquaculture, Comparative Genomics Centre, College of Marine and Environmental Sciences, James Cook University, Townsville, 4811 QLD, Australia. Electronic address: Gregory.Maes@bio.kuleuven.be.
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Maes
authors.affiliation: University of Leuven, Laboratory of Biodiversity and Evolutionary Genomics, Charles Deberiotstraat 32, B-3000 Leuven, Belgium. Electronic address: Filip.Volckaert@bio.kuleuven.be.
authors.forename: Filip A M
authors.initials: FA
authors.lastname: Volckaert
authors.affiliation: Departamento de Genética, Universidad de Santiago de Compostela, Facultad de Veterinaria, Lugo E-27002, Spain. Electronic address: paulino.martinez@usc.es.
authors.forename: Paulino
authors.initials: P
authors.lastname: Martínez
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D004777:Environment; D005412:Flatfishes / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology*; D005819:Genetic Markers; D014644:Genetic Variation; D016678:Genome
chemical_list: D005819:Genetic Markers
keywords: Adaptation; Atlantic Ocean; Fish; Population genomics