title: Toxic epidermal necrolysis induced by methazolamide in a Chinese-Korean man carrying HLA-B*59:01.
abstract: BACKGROUND
  Methazolamide is used to lower intraocular pressure in patients with glaucoma. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) associated with methazolamide treatment have been diagnosed in Korean, Japanese, and Japanese-American patients. According to recent research, the human leukocyte antigen (HLA) allele HLA-B*59:01 is strongly linked to SJS/TEN associated with methazolamide treatment.
  
  
  OBJECTIVE
  A patient of Chinese-Korean ethnicity was diagnosed with TEN associated with methazolamide treatment. The purpose of this study was to examine the potential genetic basis of this disease.
  
  
  METHODS
  A polymerase chain reaction sequence-specific primer (PCR-SSP) typing system was used to genotype this patient's peripheral blood DNA for HLA-B*59.
  
  
  RESULTS
  The genotype HLA-B*59:01 was detected in the patient.
  
  
  CONCLUSIONS
  This study demonstrates the genotype of HLA-B*59:01 in a patient with TEN associated with methazolamide treatment and thus supports the possible correlation between genetic background and methazolamide-associated SJS/TEN.
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Shu
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Duerna
authors.initials: D
authors.lastname: Tie
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Mengqing
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Dong
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Qiuning
authors.initials: Q
authors.lastname: Sun
authors.affiliation: Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Xuming
authors.initials: X
authors.lastname: Mao
authors.affiliation: Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects*; D002681:China / Q000208:ethnology; D005838:Genotype; D005901:Glaucoma / Q000188:drug therapy; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008704:Methazolamide / Q000009:adverse effects*; D056910:Republic of Korea / Q000208:ethnology; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D015235:HLA-B Antigens; C082943:HLA-B59 antigen; D008704:Methazolamide