title: [Vitamin D deficiency prediction by patient questionnaire and secondary hyperparathyroidism in a cohort of 526 healthy subjects in their fifties].
abstract: BACKGROUND
  Can vitamin D deficiency be predicted by patient questionnaire? Does it lead to secondary hyperparathyroidism that may cause excessive bone resorption? We studied non-osteoporotic subjects in their fifties, in whom vitamin D levels are often tested.
  
  
  METHODS
  Patients hospitalised for degenerative osteoarthritis or consulting for assessment of menopause, without renal failure and not treated with vitamin D, completed a questionnaire on sun exposure and underwent measurement of serum calcium, creatinine, 25OH vitamin D, PTH and CTX.
  
  
  RESULTS
  Five hundred and twenty-six subjects, mean age 54.6 years (71% women), were investigated throughout the year. 25OH vitamin D levels were correlated with sun exposure and varied according to the month of the year, unlike PTH and CTX levels. From November to May, over 90% of subjects had 25OH vitamin D levels<30ng/mL. Of the subjects who did not expose their face, arms and legs to the sun for at least 20min/day, 94% had 25OH vitamin D levels<30ng/mL. PTH levels were negatively correlated with those of 25OH vitamin D. Serum CTX levels were not correlated with PTH or 25OH vitamin D. Only 13% of subjects presented with secondary hyperparathyroidism, characterised by serum calcium<2.55mmol/L and PTH>65pg/mL, associated with increased CTX levels.
  
  
  CONCLUSIONS
  Vitamin D deficiency can be predicted by patient questionnaire. It very rarely leads to secondary hyperparathyroidism.
authors.affiliation: CHU de Toulouse, service de rhumatologie, 31059 Toulouse cedex, France. Electronic address: laroche.m@chu-toulouse.fr.
authors.forename: Michel
authors.initials: M
authors.lastname: Laroche
authors.affiliation: CHU de Toulouse, service de rhumatologie, 31059 Toulouse cedex, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Nigon
authors.affiliation: CHU de Toulouse, service de biochimie, 31059 Toulouse cedex, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gennero
authors.affiliation: CHG de Cahors, service de rhumatologie, 46000 Cahors, France.
authors.forename: Slim
authors.initials: S
authors.lastname: Lassoued
authors.affiliation: CHU de Toulouse, service de prise en charge de la ménopause, 31059 Toulouse cedex, France.
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Pouilles
authors.affiliation: CHU de Toulouse, service de prise en charge de la ménopause, 31059 Toulouse cedex, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Trémolières
authors.affiliation: CHU Toulouse, service d'explorations fonctionnelles physiologiques, 31059 Toulouse cedex, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Vallet
authors.affiliation: CHU Toulouse, service d'explorations fonctionnelles physiologiques, 31059 Toulouse cedex, France.
authors.forename: Ivan
authors.initials: I
authors.lastname: Tack
mesh_terms: D002118:Calcium / Q000097:blood; D015331:Cohort Studies; D024042:Collagen Type I / Q000097:blood; D005260:Female; D064368:Healthy Volunteers / Q000706:statistics & numerical data; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010455:Peptides / Q000097:blood; D011379:Prognosis; D011795:Surveys and Questionnaires; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications / Q000175:diagnosis*
chemical_list: D024042:Collagen Type I; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D014807:Vitamin D; D002118:Calcium