title: Primary extranodal marginal zone B-cell lymphoma with diffuse uveal involvement and focal infiltration of the trabecular meshwork: a case report and review of literature.
abstract: BACKGROUND
  Primary extranodal marginal zone lymphoma (EMZL) of the uvea is a rare condition and diagnosis may be challenging. We aim to report the clinical, histopathologic and immunohistochemical findings in a case of primary EMZL with diffuse uveal involvement and focal infiltration of the trabecular meshwork.
  
  
  METHODS
  A 38-year-old male presented with 2-year progressive vision loss in the right eye. Fundus examination showed choroidal thickening with diffuse retinal pigment epithelium (RPE) changes and inferior exudative retinal detachment. Ultrasonography revealed low-reflective masses with diffuse thickening of the choroid involving the optic nerve and orbit. Despite treatment with steroids, his symptoms progressed over time. One year later, visual acuity of the right eye markedly decreased to no light perception and enucleation was performed. Histopathological findings revealed infiltrates of malignant cells in the choroid, iris, ciliary body and trabecular meshwork. Immunohistochemistry confirmed the diagnosis of primary uveal EMZL.
  
  
  CONCLUSIONS
  This is the first case reporting primary EMZL diffusely involving the uvea with focal infiltration of the trabecular meshwork.
authors.affiliation: Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing, 100005, China. drxinxiaogao@hotmail.com.|Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. drxinxiaogao@hotmail.com.
authors.forename: Xinxiao
authors.initials: X
authors.lastname: Gao
authors.affiliation: Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing, 100005, China. libin43_99@163.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing, 100005, China. qishengbio@163.com.
authors.forename: Qisheng
authors.initials: Q
authors.lastname: You
authors.affiliation: Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 17 Hougou Lane, Chongnei Street, Beijing, 100005, China. drpengxy@yeah.net.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Peng
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D015353:Eye Enucleation; D005451:Fluorescein Angiography; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D064847:Multimodal Imaging; D009361:Neoplasm Invasiveness; D014129:Trabecular Meshwork / Q000473:pathology*; D014463:Ultrasonography; D014602:Uvea / Q000473:pathology*; D014604:Uveal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor