title: Late-onset adverse reactions related to hyaluronic Acid dermal filler for aesthetic soft tissue augmentation.
abstract: Hyaluronic acid (HA) fillers have been the choice material for soft tissue augmentation in the last decade. Although they are considered safe, there could be adverse reactions in the subsequent months or years to the treatment. However, these reactions have hardly ever been reported in the literature. This article considers 2 cases of delayed adverse reactions related to HA dermal filler for soft tissue augmentation with oral manifestation. It should be, before all, emphasized that HA filler is a safe and well-recognized treatment for soft tissue augmentation, despite the fact that delayed adverse effects may later occur after treatment, and clinicians should be aware of it when establishing a definitive oral diagnosis.
authors.affiliation: *Department of Stomatology, Hospital Santa Catarina †Department of Oral Surgery, University Sagrado Coração, Sao Paulo, Brazil.
authors.forename: Marcos Martins
authors.initials: MM
authors.lastname: Curi
authors.forename: Camila Lopes
authors.initials: CL
authors.lastname: Cardoso
authors.forename: Cláudia
authors.initials: C
authors.lastname: Curra
authors.forename: Daniel
authors.initials: D
authors.lastname: Koga
authors.forename: Maria Beatriz
authors.initials: MB
authors.lastname: Benini
mesh_terms: D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000009:adverse effects*; D000067548:Dermal Fillers / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005547:Foreign Bodies / Q000601:surgery; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage; D007279:Injections, Subcutaneous; D008046:Lip / Q000601:surgery*; D035421:Parotid Region / Q000601:surgery; D011183:Postoperative Complications / Q000601:surgery; D012086:Reoperation; D013518:Surgery, Plastic / Q000009:adverse effects* / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D000067548:Dermal Fillers; D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase; C445361:Restylane