title: Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}(6) complex.
abstract: The photo-initiated cytotoxicity of a newly developed manganese nitrosyl {MnNO}(6) complex (UG1NO) to HeLa cells is described. The complex was found to be strongly cytotoxic after being exposed to light with a wavelength of 650 nm. Cell death was caused by a manganese(II) complex, UG1, generated from UG1NO through the photo-dissociation of NO, rather than by NO directly. Mechanistic studies revealed that UG1 consumes O2 only in the presence of a reducing agent to catalytically produce H2O2.
authors.affiliation: Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 1-3 Miyakodani, Tatara, 610-0321 Kyotanabe, Japan. yhitomi@mail.doshisha.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: Masahito
authors.initials: M
authors.lastname: Kodera
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hitomi
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D002384:Catalysis; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D005978:Glutathione / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry*; D008027:Light; D008345:Manganese / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D009569:Nitric Oxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D009569:Nitric Oxide; D008345:Manganese; D006861:Hydrogen Peroxide; D005978:Glutathione