title: Asymmetric synthesis of quaternary α-fluoro-β-keto-amines via detrifluoroacetylative Mannich reactions.
abstract: Efficient asymmetric detrifluoroacetylative Mannich addition reactions between 2-fluoro-1,3-di-ketones/hydrates and chiral N-sulfinyl-imines via C-C bond cleavage were reported, which afforded C-F quaternary α-fluoro-β-keto-amines with excellent yields and high diastereoselectivity.
authors.affiliation: School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, China. hanjl@nju.edu.cn.
authors.forename: Chen
authors.initials: C
authors.lastname: Xie
authors.forename: Yanling
authors.initials: Y
authors.lastname: Dai
authors.forename: Haibo
authors.initials: H
authors.lastname: Mei
authors.forename: Jianlin
authors.initials: J
authors.lastname: Han
authors.forename: Vadim A
authors.initials: VA
authors.lastname: Soloshonok
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007097:Imines; D007659:Ketones; D005461:Fluorine