title: Controlling T cell senescence in the tumor microenvironment for tumor immunotherapy.
abstract: Understanding molecular mechanisms involved in creating and sustaining the tumor suppressive microenvironment is critical for the development of novel antitumor therapeutic strategies. We have identified the induction of T cell senescence as a novel mechanism utilized by human tumor cells to induce immune suppression, and provided a new strategy using TLR8 ligands to reverse tumor immunosuppressive effects for tumor immunotherapy.
authors.affiliation: Division of Infectious Diseases; Allergy & Immunology and Department of Internal Medicine; Saint Louis University School of Medicine ; Saint Louis, MO, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Ye
authors.affiliation: Division of Infectious Diseases; Allergy & Immunology and Department of Internal Medicine; Saint Louis University School of Medicine ; Saint Louis, MO, USA.
authors.forename: Guangyong
authors.initials: G
authors.lastname: Peng
keywords: cAMP; immunosenescence; regulatory T cells; toll-like receptor; tumor immunotherapy, tumor microenvironment