title: Severe adverse effects of 5-fluorouracil in S-1 were lessened by haemodialysis due to elimination of the drug.
abstract: S-1 and cisplatin are used as one of the first-line chemotherapies for gastric cancer in Japan. The plasma concentration of 5-fluorouracil (5-FU) is increased in patients with renal dysfunction because gimeracil in S-1 inhibits the degradation of 5-FU and about 50% of gimeracil is excreted in the urine. We describe a 35-year-old man with acute kidney injury while taking S-1 and cisplatin for advanced gastric cancer and who presented severe adverse effects of 5-FU. This case report describes the evolution of the plasma concentrations of 5-FU with haemodialysis along with a decrease in the adverse drug effects.
authors.affiliation: Department of Geriatric Medicine and Nephrology , Osaka University Graduate School of Medicine , Osaka , Japan.
authors.forename: Kazunori
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Department of Geriatric Medicine and Nephrology , Osaka University Graduate School of Medicine , Osaka , Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nagasawa
authors.affiliation: Department of Geriatric Medicine and Nephrology , Osaka University Graduate School of Medicine , Osaka , Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Yamamoto
authors.affiliation: Department of Geriatric Medicine and Nephrology , Osaka University Graduate School of Medicine , Osaka , Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Omori
authors.affiliation: Department of Geriatric Medicine and Nephrology , Osaka University Graduate School of Medicine , Osaka , Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kimura
authors.affiliation: Department of Geriatric Medicine and Nephrology , Osaka University Graduate School of Medicine , Osaka , Japan.
authors.forename: Kodo
authors.initials: K
authors.lastname: Tomida
authors.affiliation: Department of Geriatric Medicine and Nephrology , Osaka University Graduate School of Medicine , Osaka , Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Furumatsu
authors.affiliation: Department of Geriatric Medicine and Nephrology , Osaka University Graduate School of Medicine , Osaka , Japan.
authors.forename: Enyu
authors.initials: E
authors.lastname: Imai
authors.affiliation: Department of Geriatric Medicine and Nephrology , Osaka University Graduate School of Medicine , Osaka , Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Isaka
authors.affiliation: Department of Geriatric Medicine and Nephrology , Osaka University Graduate School of Medicine , Osaka , Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Rakugi
keywords: 5-fluorouracil; S-1; gimeracil; haemodialysis