title: Acute kidney injury in patients with chronic liver disease.
abstract: Acute kidney injury (AKI) is a frequent clinical event in patients with liver disease, compounding their prognosis. Furthermore, it is likely that the occurrence of AKI has a detrimental impact on the subsequent renal function and the long-term survival of these patients. Recently, some authors advocated the use of new diagnostic criteria for detecting acute kidney injury in patients with cirrhosis. These criteria are based on the rapidity and extent of the creatinine increase comparing to the basal creatinine and also on the kinetics of diuresis decrease. Although their validity in this population requires further studies to be clearly established, these new criteria could have two advantages: (1) to allow earlier diagnosis of AKI and, thus, hepatorenal syndrome for which earlier intervention could improve patients' survival; and (2) to promote more intensive monitoring of renal function in these patients with high risk of AKI. Finally, recent practice guidelines about the prevention and treatment of general AKI have been published which should be useful in optimising the management of AKI in cirrhotic patients.
authors.affiliation: Nicolas Rognant, Nephrology Department, Centre Hospitalier Lyon-Sud, F69495 Pierre Benite Cedex, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Rognant
keywords: Acute kidney injury; Cirrhosis; Hepatorenal syndrome; RIFLE/AKIN classification; Serum creatinine