title: [Preparation stimulating hair growth possibly acts by inhibiting hair follicle ageing experiments on mice and transcriptome analysis].
abstract: Preparation stimulating hair growth (PSHG) was studied on mice of various strains (Balb/c, CBA, C57BI/6, and outbred). It was shown that a long-term (44 months) application of PSHG does not reliably affect the appearance of young healthy mice but does induce increase in the hair follicle size. No adverse consequences of the PSHG application were observed. Naturally occurring propagating regenerative hair waves peculiar to mice were preserved. In older mice (more than 2 years) with signs of alopecia, application of PSHG caused an overgrowing of bald patches within two months. Transcriptome analysis of the PSHG effect performed in fibroblast cell culture showed that PSHG stimulates processes of tissue development and remodeling. These observations together with previous findings showing that PSHG stimulates autophagy and induces death of cells subjected to oxidative stress may suggest that the mechanism of the PSHG effect involves stimulation of regeneration of skin and its derivatives owing to more efficient elimination of senescent and damaged follicle cells.
authors.forename: Kh S
authors.initials: KhS
authors.lastname: Vishniakova
authors.forename: L G
authors.initials: LG
authors.lastname: Vetkova
authors.forename: A M
authors.initials: AM
authors.lastname: Aliper
authors.forename: A A
authors.initials: AA
authors.lastname: Zhavoronkov
authors.forename: A V
authors.initials: AV
authors.lastname: Snezhkina
authors.forename: A V
authors.initials: AV
authors.lastname: Kudriavtseva
authors.forename: K V
authors.initials: KV
authors.lastname: Popov
authors.forename: E E
authors.initials: EE
authors.lastname: Egorov
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D001343:Autophagy / Q000187:drug effects; D001453:Balsams / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D020869:Gene Expression Profiling; D018859:Hair Follicle / Q000187:drug effects / Q000254:growth & development* / Q000473:pathology / Q000502:physiology; D006801:Humans; D008297:Male; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D018384:Oxidative Stress / Q000187:drug effects; D061251:Primary Cell Culture; D012313:RNA / Q000235:genetics; D012038:Regeneration / Q000187:drug effects / Q000235:genetics; D012624:Seaweed / Q000737:chemistry*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D059467:Transcriptome / Q000187:drug effects*
chemical_list: D001453:Balsams; D012313:RNA