title: Mashhad stroke and heart atherosclerotic disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk estimation.
abstract: OBJECTIVE
  The Mashhad stroke and heart atherosclerotic disorder (MASHAD) study is a 10-year cohort study that aims to evaluate the impact of various genetic, environmental, nutritional and psychosocial risk factors on the incidence of cardiovascular events among an urban population in eastern Iran.
  
  
  METHODS
  The MASHAD study comprises a cohort of 9704 individuals aged 35-65 years using a stratified cluster random sampling design. This cohort will be followed up until 2020, with follow-up examinations being undertaken every 3 years. Ten-year cardiovascular disease (CVD) risk estimation was determined using NCEP ATP III criteria.
  
  
  RESULTS
  Overall, 88.4 % of women and 79.2 % of men (P < 0.001) had at least one lipid abnormality. The 10-year risk for CVD of <10, 10-20 and >20 % were observed to be 86.6, 11 and 2.5 %, respectively. Predicted risk of CVD > 10 % using the Framingham algorithm was considerably higher in men compared to women. Overall, 9.5 % [95 % confidence interval (CI) 8.9-10.1 %] of our subjects had prevalent CAD.
  
  
  CONCLUSIONS
  The prevalence of CVD risk factors within our population is high compared to Western countries, indicating the necessity for interventional risk modifications.
authors.affiliation: Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Mohsen
authors.initials: M
authors.lastname: Moohebati
authors.forename: Habibollah
authors.initials: H
authors.lastname: Esmaily
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Ebrahimi
authors.forename: Seyed Mohammad Reza
authors.initials: SM
authors.lastname: Parizadeh
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Heidari-Bakavoli
authors.forename: Mohammad
authors.initials: M
authors.lastname: Safarian
authors.forename: Naghmeh
authors.initials: N
authors.lastname: Mokhber
authors.forename: Mohsen
authors.initials: M
authors.lastname: Nematy
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Saber
authors.forename: Maryam
authors.initials: M
authors.lastname: Mohammadi
authors.forename: Mohammad Sobhan Sheikh
authors.initials: MS
authors.lastname: Andalibi
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Ferns
authors.forename: Mahmoud Reza
authors.initials: MR
authors.lastname: Azarpazhooh
mesh_terms: D000328:Adult; D001007:Anxiety / Q000453:epidemiology; D001786:Blood Glucose; D001794:Blood Pressure; D001837:Body Weights and Measures; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000453:epidemiology*; D003863:Depression / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D015438:Health Behavior; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D008019:Life Style; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012107:Research Design; D012307:Risk Factors; D012959:Socioeconomic Factors; D020521:Stroke / Q000453:epidemiology*
chemical_list: D001786:Blood Glucose; D008055:Lipids