title: Pyoderma gangrenosum with common variable immunodeficiency.
abstract: Pyoderma gangrenosum (PG) is a rare ulcerative skin disease of unknown etiology. It can be seen on normal skin or secondary to traumas such as injections and biopsies. Half of reported cases are associated with systemic diseases such as arthritis, inflammatory bowel diseases, hematological disorders, hepatic disease, and necrotizing vasculitis. These lesions often occur on the trunk and extremities. Abscess drainage, debridement, or necrosectomy are contraindicated in PG, and false management of these indications aggravates the lesion. A diagnosis of PG is based on medical history as well as physical and laboratory examination according to standard criteria. Presented here is a case of a male patient with a medical history of recurrent abscess of injection and splenectomy due to splenic abscess. The patient presented with a subcutaneous abscess which transformed rapidly to an ulcer after abscess drainage. Consequently, the patient received the final diagnosis of PG with common variable immunodeficiency and was treated accordingly.
authors.affiliation: Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Simsek
authors.affiliation: Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Kivilcim
authors.initials: K
authors.lastname: Ulusan
authors.affiliation: Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Anil
authors.initials: A
authors.lastname: Orhan
authors.affiliation: Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Kırıs
authors.affiliation: Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey; email:akocael147@yahoo.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kocael
authors.affiliation: Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Kocael
mesh_terms: D000328:Adult; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000276:immunology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage*; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D012883:Skin Ulcer / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D013156:Splenectomy / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D011239:Prednisolone