title: Role of microRNAs in hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer related death worldwide. HCC develops through a multistep process that involves genetic and epigenetic changes. In addition to genetic and epigenetic mechanisms, recent studies have shown that microRNAs (miRNAs) play essential roles in hepatocellular carcinogenesis through the post-transcriptional regulation of tumor associated-genes. In this review, we summarize the role of miRNAs in HCC and its microenvironment, and discuss the implications for HCC therapy.
authors.forename: Lin-Na
authors.initials: LN
authors.lastname: Liu
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Li
authors.affiliation: Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, Shanghai 200072, China, huixiong_xu@163.com.
authors.forename: Hui-Xiong
authors.initials: HX
authors.lastname: Xu
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Zheng
authors.affiliation: 1.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Zhang
mesh_terms: D017209:Apoptosis / Q000235:genetics; D014408:Biomarkers, Tumor; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology; D009361:Neoplasm Invasiveness / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000235:genetics; D011379:Prognosis; D059016:Tumor Microenvironment
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs