title: The Future of Polycystic Kidney Disease Research--As Seen By the 12 Kaplan Awardees.
abstract: Polycystic kidney disease (PKD) is one of the most common life-threatening genetic diseases. Jared J. Grantham, M.D., has done more than any other individual to promote PKD research around the world. However, despite decades of investigation there is still no approved therapy for PKD in the United States. In May 2014, the University of Kansas Medical Center hosted a symposium in Kansas City honoring the occasion of Dr. Grantham's retirement and invited all the awardees of the Lillian Jean Kaplan International Prize for Advancement in the Understanding of Polycystic Kidney Disease to participate in a forward-thinking and interactive forum focused on future directions and innovations in PKD research. This article summarizes the contributions of the 12 Kaplan awardees and their vision for the future of PKD research.
authors.affiliation: National Institute of Health and Medical Research, Laboratory of Inherited Kidney Diseases, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, and The Department of Genetics, Necker Hospital, Paris, France;
authors.forename: Corinne
authors.initials: C
authors.lastname: Antignac
authors.affiliation: The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas; ayu@kumc.edu JCALVET@kumc.edu.
authors.forename: James P
authors.initials: JP
authors.lastname: Calvet
authors.affiliation: Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland;
authors.forename: Gregory G
authors.initials: GG
authors.lastname: Germino
authors.affiliation: The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas;
authors.forename: Jared J
authors.initials: JJ
authors.lastname: Grantham
authors.affiliation: Center for Translational Science, Children's National Health System, Washington, DC;
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Guay-Woodford
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota;
authors.forename: Peter C
authors.initials: PC
authors.lastname: Harris
authors.affiliation: Howard Hughes Medical Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts;
authors.forename: Friedhelm
authors.initials: F
authors.lastname: Hildebrandt
authors.affiliation: Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;
authors.forename: Dorien J M
authors.initials: DJ
authors.lastname: Peters
authors.affiliation: Departments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, Connecticut;
authors.forename: Stefan
authors.initials: S
authors.lastname: Somlo
authors.affiliation: Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota;
authors.forename: Vicente E
authors.initials: VE
authors.lastname: Torres
authors.affiliation: Renal Division, Department of Medicine, University Medical Center Freiburg, Freiburg, Germany; and.
authors.forename: Gerd
authors.initials: G
authors.lastname: Walz
authors.affiliation: Harvard Center for Polycystic Kidney Disease Research, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.affiliation: The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas; ayu@kumc.edu JCALVET@kumc.edu.
authors.forename: Alan S L
authors.initials: AS
authors.lastname: Yu
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends*; D002923:Cilia / Q000235:genetics* / Q000378:metabolism; D060045:Genes, Modifier; D006801:Humans; D007684:Kidney Tubules; D000076222:Mechanistic Target of Rapamycin Complex 1; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D058990:Molecular Targeted Therapy; D046912:Multiprotein Complexes / Q000378:metabolism; D010641:Phenotype; D016891:Polycystic Kidney, Autosomal Dominant / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D051437:Renal Insufficiency / Q000517:prevention & control; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D050396:TRPP Cation Channels / Q000235:genetics* / Q000378:metabolism
chemical_list: D000076222:Mechanistic Target of Rapamycin Complex 1; D008869:Microtubule-Associated Proteins; D046912:Multiprotein Complexes; D058570:TOR Serine-Threonine Kinases; D050396:TRPP Cation Channels; C000594121:TTC21B protein, human
keywords: genetic renal disease; genetics and development; polycystic kidney disease