title: Th1 chemokines in ulcerative colitis.
abstract: Many studies have shown that chemokine (C-X-C motif) receptor (CXCR)3 (a chemokine receptor in the CXC family) and its ligand chemokines, monokine induced by interferon (IFN)-γ(MIG), IFN-γ-inducible protein 10 (IP-10) and IFN-inducible T-cell α chemoattractant (I-TAC), are strongly overexpressed in the intestinal mucosa of mice with experimental colitis, and in patients with ulcerative colitis (UC) both in lymphocytes, in macrophages and in epithelial cells. IFN-γ induces CXCR3 and its chemokines expression in epithelial colonic cells; MIG, IP-10 and I-TAC are important for the recruitment of granulocytes and mononuclear cells and thus for the maintenance of inflammation in UC. Serum IP-10 levels reflected UC disease activity, and it may be a marker for the responsiveness of patients to treatments. Recently, a phase II study suggested that an anti-IP-10 antibody, BMS-936557, is a potentially effective therapy for moderately-to-severely active UC.
authors.affiliation: Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ragusa
mesh_terms: D000818:Animals; D054357:Chemokine CXCL10 / Q000097:blood; D054371:Chemokine CXCL11 / Q000378:metabolism; D054370:Chemokine CXCL9 / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology; D007413:Intestinal Mucosa / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D051379:Mice; D054367:Receptors, CXCR3 / Q000378:metabolism; D018417:Th1 Cells / Q000378:metabolism*
chemical_list: C114753:CXCL10 protein, human; C515187:CXCR3 protein, human; D054357:Chemokine CXCL10; D054371:Chemokine CXCL11; D054370:Chemokine CXCL9; D054367:Receptors, CXCR3; D007371:Interferon-gamma
keywords: Anti-IP-10 antibody; CXCR3; IP-10; Ulcerative colitis