title: Copper-catalyzed aerobic oxidative C-C bond cleavage of unstrained ketones with air and amines.
abstract: A unique copper-catalyzed aerobic oxidative C-C bond cleavage of simple unstrained ketones with air and amines has been developed. In this chemistry, amides and oxo amides are easily synthesized through the selective C-C bond cleavage of simple ketones or unstrained cycloketones. The broad substrate scopes and use of an inexpensive copper catalyst and green molecular oxygen as an oxidant as well as an O-source make this protocol very attractive for potential synthetic applications. The control experiments reveal that the present copper-catalyzed oxidative C-C bond cleavage of simple ketones proceeds in a novel catalytic pathway rather than through the cleavage of a dioxetane intermediate.
authors.affiliation: †College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Zhou
authors.affiliation: †College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
authors.forename: Wenyou
authors.initials: W
authors.lastname: Fan
authors.affiliation: †College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China.
authors.forename: Qijian
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: ‡State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Liang
authors.affiliation: ‡State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao