title: 3'-UTR polymorphism (rs10434) in the VEGF gene is associated with B-CLL in a Chinese population.
abstract: We investigated the relationship between a VEGF genetic polymorphism and B cell chronic lymphocytic leukemia (B-CLL). A total of 102 patients with B-CLL and 124 healthy subjects were included in this study. All individuals were typed for the rs10434 in the vascular endothelial growth factor (VEGF) gene using the TaqMan technique. We found that the A allele and the AA genotype of rs10434 were more frequent in B-CLL patients than in control subjects (0.54 vs 0.34; 27 vs 13%; respectively). VEGF alleles and genotypes segregated similarly in patients at different disease stages according to Rai classification. These results suggest a possible association between the VEGF polymorphism and high-risk B-CLL.
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: L X
authors.initials: LX
authors.lastname: Zhu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China yxjsunny_yx@163.com.
authors.forename: X J
authors.initials: XJ
authors.lastname: Ye
authors.affiliation: Departamento de Biologia/Nupélia, Universidade Estadual de Maringá, Maringá, PR, Brasil.
authors.forename: Y G
authors.initials: YG
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: J J
authors.initials: JJ
authors.lastname: Zhu
authors.affiliation: Department of Hematology, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: W Z
authors.initials: WZ
authors.lastname: Xie
authors.affiliation: Bone Marrow Transplant Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Zhao
authors.affiliation: Bone Marrow Transplant Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Lai
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A