title: Primaquine dosing errors: the human cost of a pharmaceutical anachronism.
abstract: Confusion between salt/base forms of primaquine may result in malaria prophylaxis failure. During 1995-2011, there were 14 malaria cases in Israel despite primaquine primary prophylaxis. In 6/14 cases, primaquine was underdosed because of confusion between salt and base forms, including two Plasmodium falciparum cases. Primaquine labeling clarification may be lifesaving.
authors.affiliation: The Center for Geographic Medicine and Department of Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel emeltzer@post.tau.ac.il elischwa@post.tau.ac.il.
authors.forename: Eyal
authors.initials: E
authors.lastname: Meltzer
authors.affiliation: The Center for Geographic Medicine and Department of Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Lindsay
authors.initials: L
authors.lastname: Morrison
authors.affiliation: The Center for Geographic Medicine and Department of Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Shmuel
authors.initials: S
authors.lastname: Stienlauf
authors.affiliation: The Center for Geographic Medicine and Department of Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel emeltzer@post.tau.ac.il elischwa@post.tau.ac.il.
authors.forename: Eli
authors.initials: E
authors.lastname: Schwartz
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage*; D018890:Chemoprevention; D015331:Cohort Studies; D004304:Dosage Forms; D005260:Female; D006801:Humans; D007557:Israel; D016778:Malaria, Falciparum / Q000517:prevention & control*; D016780:Malaria, Vivax / Q000517:prevention & control*; D008297:Male; D008508:Medication Errors; D011319:Primaquine / Q000008:administration & dosage*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000962:Antimalarials; D004304:Dosage Forms; D011319:Primaquine