title: Energy dependence of the complexity of DNA damage induced by carbon ions.
abstract: To assess the complexity of DNA damage induced by carbon ions as a function of their energy and LET, 2-Gy irradiations by 100 keV u(-1)-400 MeV u(-1) carbon ions were investigated using the PARTRAC code. The total number of fragments and the yield of fragments of <30 bp were calculated. The authors found a particularly important contribution of DNA fragmentation in the range of <1 kbp for specific energies of <6 MeV u(-1). They also considered the effect of different specific energies with the same LET, i.e. before and after the Bragg peak. As a first step towards a full characterisation of secondary particle production from carbon ions interacting with tissue, a comparison between DNA-damage induction by primary carbon ions and alpha particles resulting from carbon break-up is presented, for specific energies of >1 MeV u(-1).
authors.affiliation: Department of Physics, University of Pavia, Via Bassi 6, Pavia, Italy LENA, Laboratory of Applied Nuclear Energy, University of Pavia, Via Aselli 41, Pavia, Italy INFN National Institute of Nuclear Physics, Sezione di Pavia, Via Bassi 6, Pavia, Italy daniele.alloni@unipv.it.
authors.forename: D
authors.initials: D
authors.lastname: Alloni
authors.affiliation: Department of Physics, University of Pavia, Via Bassi 6, Pavia, Italy INFN National Institute of Nuclear Physics, Sezione di Pavia, Via Bassi 6, Pavia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Baiocco
authors.affiliation: Department of Physics, University of Pavia, Via Bassi 6, Pavia, Italy INFN National Institute of Nuclear Physics, Sezione di Pavia, Via Bassi 6, Pavia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Babini
authors.affiliation: Institute of Radiation Protection, Helmholtz Zentrum München, Neuherberg 85764, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Friedland
authors.affiliation: Institute of Radiation Protection, Helmholtz Zentrum München, Neuherberg 85764, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Kundrát
authors.affiliation: Department of Physics, University of Pavia, Via Bassi 6, Pavia, Italy INFN National Institute of Nuclear Physics, Sezione di Pavia, Via Bassi 6, Pavia, Italy Department of Oncology, Gray Institute for Radiation Oncology and Biology, Old Road Campus Research Building, Off Roosevelt Drive, Oxford OX3 7DQ, UK.
authors.forename: L
authors.initials: L
authors.lastname: Mariotti
authors.affiliation: Department of Physics, University of Pavia, Via Bassi 6, Pavia, Italy INFN National Institute of Nuclear Physics, Sezione di Pavia, Via Bassi 6, Pavia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ottolenghi
mesh_terms: D000512:Alpha Particles / Q000009:adverse effects*; D002244:Carbon / Q000009:adverse effects*; D003198:Computer Simulation; D004249:DNA Damage / Q000528:radiation effects*; D006801:Humans; D018499:Linear Energy Transfer / Q000528:radiation effects*; D011829:Radiation Dosage
chemical_list: D002244:Carbon