title: A fatal case of poisoning with ethanol and psychotropic drugs with putrefactive changes.
abstract: We present a fatal case involving poisoning with paroxetine, flunitrazepam, and ethanol, with putrefactive changes. Quantitative toxicological analysis showed that the concentrations of paroxetine and 7-aminoflunitrazepam, a metabolite of flunitrazepam, in the femoral blood were 0.28 µg/ml and 0.17 µg/ml, respectively. We also detected an ethanol level of 2.90 mg/ml and an n-propanol level of 0.10 mg/ml. We concluded that the cause of death was due to the interaction of paroxetine, flunitrazepam, and ethanol. The effects of putrefactive changes should be considered during forensic toxicological evaluation.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Naoko
authors.initials: N
authors.lastname: Tanaka
authors.forename: Mostofa
authors.initials: M
authors.lastname: Jamal
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kumihashi
authors.forename: Ayaka
authors.initials: A
authors.lastname: Takakura
authors.forename: T
authors.initials: T
authors.lastname: Tobiume
authors.forename: Kunihito
authors.initials: K
authors.lastname: Tsutsui
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ameno
mesh_terms: D000431:Ethanol / Q000097:blood / Q000506:poisoning*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000097:blood / Q000506:poisoning*
chemical_list: D011619:Psychotropic Drugs; D000431:Ethanol
keywords: flunitrazepam - ethanol - paroxetine - gas chromatography mass spectrometry (GC/MS).