title: The Discovery of Novel Selective D1 Dopaminergic Agonists: A-68930, A-77636, A-86929, and ABT-413.
abstract: The novel selective D1 dopaminergic full agonists A-68930, A-77636 were discovered by the synthesis of molecules to probe the bioactive conformation of the partial agonist SKF-38393, by the use of this information to add D1 affinity and selectivity to a screening hit, and by traditional medicinal chemistry exploration of structure-activity relationships. The subsequent design of A-86929 and ABT-413 capitalized on these results, recently disclosed agonists, and traditional medicinal chemistry.
authors.affiliation: Department of Global Pharmaceutical Research and Development, Martin Consulting, Waukegan, IL 60064, USA.
authors.forename: Yvonne Connolly
authors.initials: YC
authors.lastname: Martin