title: Treatment of Sézary Syndrome With Alemtuzumab: A Series of 5 Cases and a Review of the Literature.
abstract: Alemtuzumab is a monoclonal antibody that has been used to treat refractory cases of Sézary syndrome (SS) and advanced mycosis fungoides. We present 5 patients with SS who were treated with alemtuzumab between 2008 and 2012, with an overall response rate of 80% (40% partial response and 40% complete response). A regimen of 10mg administered subcutaneously was well tolerated with acceptable toxicity. The median duration of response was 13 months. However, one patient remains in complete remission after 67 months, a remarkable outcome given the low survival rate associated with SS. In conclusion, we believe that alemtuzumab may be useful in cases of SS refractory to other treatments. As there are no curative treatments for SS, alemtuzumab should be considered as a therapeutic option.
authors.affiliation: Servicio de Dermatología, Hospital Universitario Donostia, San Sebastián, España. Electronic address: elenadelalcazarviladomiu@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: del Alcázar-Viladomiu
authors.affiliation: Servicio de Dermatología, Hospital Universitario Donostia, San Sebastián, España.
authors.forename: A
authors.initials: A
authors.lastname: Tuneu-Valls
authors.affiliation: Servicio de Dermatología, Hospital Universitario Donostia, San Sebastián, España.
authors.forename: A
authors.initials: A
authors.lastname: López-Pestaña
authors.affiliation: Servicio de Hematología, Hospital Universitario Donostia, San Sebastián, España.
authors.forename: M J
authors.initials: MJ
authors.lastname: Vidal-Manceñido
mesh_terms: D000074323:Alemtuzumab; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008212:Lymphocyte Depletion; D008228:Lymphoma, Non-Hodgkin; D008297:Male; D010789:Phototherapy; D012074:Remission Induction; D016879:Salvage Therapy; D012751:Sezary Syndrome / Q000188:drug therapy* / Q000628:therapy; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000074323:Alemtuzumab
keywords: Alemtuzumab; Sézary syndrome; Síndrome de Sézary; Tratamiento; Treatment