title: The effect of orally administered ranitidine and once-daily or twice-daily orally administered omeprazole on intragastric pH in cats.
abstract: BACKGROUND
  Gastric acid suppressants frequently are used in cats with acid-related gastric disorders. However, it is not known if these drugs effectively increase intragastric pH in cats.
  
  
  OBJECTIVE
  To examine the effects of PO administered ranitidine and omeprazole on intragastric pH in cats and to compare the efficacy of once-daily versus twice-daily dosage regimens for omeprazole.
  
  
  METHODS
  Eight domestic shorthair cats.
  
  
  METHODS
  Using a randomized 4-way cross-over design, cats were given enteric-coated omeprazole granules (1.1-1.3 mg/kg q24h and q12h), ranitidine (1.5-2.3 mg/kg q12h), and placebo. Intragastric pH was monitored continuously for 96 hours using the Bravo(™) system, starting on day 4 of treatment, followed by a median washout period of 12 days. Mean percentage of time pH was ≥3 and ≥4 was compared among groups using repeated measures ANOVA.
  
  
  RESULTS
  Mean ± SD percentage of time intragastric pH was ≥3 and ≥4 was 67.0 ± 24.0% and 54.6 ± 26.4% for twice-daily omeprazole, 24.4 ± 22.8% and 16.8 ± 19.3% for once-daily omeprazole, 16.5 ± 9.0% and 9.6 ± 5.9% for ranitidine, and 9.4 ± 8.0% and 7.0 ± 6.6% for placebo administration. Twice-daily omeprazole treatment significantly increased intragastric pH, whereas pH after once-daily omeprazole and ranitidine treatments did not differ from that of placebo-treated cats.
  
  
  CONCLUSIONS
  Only twice-daily PO administered omeprazole significantly suppressed gastric acidity in healthy cats, whereas once-daily omeprazole and standard dosages of ranitidine were not effective acid suppressants in cats.
authors.affiliation: Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Šutalo
authors.affiliation: Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Ruetten
authors.affiliation: Section of Epidemiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Hartnack
authors.affiliation: Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
authors.forename: C E
authors.initials: CE
authors.lastname: Reusch
authors.affiliation: Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
authors.forename: P H
authors.initials: PH
authors.lastname: Kook
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats; D018592:Cross-Over Studies; D004334:Drug Administration Schedule / Q000662:veterinary; D005260:Female; D005745:Gastric Acidity Determination / Q000662:veterinary; D006863:Hydrogen-Ion Concentration; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000494:pharmacology*; D011899:Ranitidine / Q000008:administration & dosage / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects*; D013608:Tablets, Enteric-Coated
chemical_list: D000897:Anti-Ulcer Agents; D013608:Tablets, Enteric-Coated; D011899:Ranitidine; D009853:Omeprazole
keywords: Acid suppressant; Feline; Omeprazole; Ranitidine