title: Myocardial protective effects of Munziq in myocardial ischemia-reperfusion injury rats with abnormal savda syndrome.
abstract: This study evaluated the influence and mechanism of different Munziq doses on myocardial ischemia reperfusion injury (MIRI) rats with abnormal savda. Wistar rats (N = 96) were divided into the following 8 groups (12 rats each): ischemia-reperfusion (I/R) model group, high-dose, medium-dose, and low-dose Munziq groups, normal I/R group, sham model group, normal sham group, and Atorvastatin group. Changes in heart physiology and myocardial morphology after injury with MIRI were monitored in each group. Heat shock protein 70 (HSP70) and calcitonin gene-related peptide (CGRP) protein expression and serum concentrations of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin (IL)-6, and IL-8 were detected by using western blot and ELISA methods, respectively. The large-dose Munziq group showed the most significant changes. The VPC incurring time was not delayed in the small-dose group, but the accumulative time was significantly reduced (P < 0.01). The ventricular tachycardia incurring time did not differ significantly between groups. Compared with the normal sham surgical group, the I/R groups showed significant increases in HSP70 and CGRP expression (P < 0.01) and MDA, IL-6, and IL-8 concentrations (P < 0.05) and a significant decrease in the SOD concentration (P < 0.05). Compared with the I/R groups, Munziq intervention significantly enhanced HSP70 and CGRP expression (P < 0.01), significantly decreased MDA, IL-6, and IL-8 concentrations (P < 0.05), and significantly increased the SOD concentration (P < 0.05). In conclusion, Munziq intervention improves cardiac physiological function, increases the expression of HSP70 and CGRP, and decreases the inflammatory reaction in MIRI model rats.
authors.affiliation: Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: M
authors.initials: M
authors.lastname: Abudunaibi
authors.affiliation: Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China nebi-boss@hotmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Mulati
authors.affiliation: Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: S
authors.initials: S
authors.lastname: Aisikaer
authors.affiliation: Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: M
authors.initials: M
authors.lastname: Zulifeiya
authors.affiliation: Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: J
authors.initials: J
authors.lastname: Qiao
authors.affiliation: Otolaryngology Department of Xinjiang Autonomous Region People's Hospital, Xinjiang, China.
authors.forename: M
authors.initials: M
authors.lastname: Gulibositan
authors.affiliation: Department of Cardiac Surgery, First Teaching Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
authors.forename: A
authors.initials: A
authors.lastname: Aili
authors.affiliation: Uyghur Medicine Institute of Xinjiang Medical University, Xingiang, China.
authors.forename: U
authors.initials: U
authors.lastname: Halmurat
mesh_terms: D000818:Animals; D062186:Arterial Pressure; D000069059:Atorvastatin / Q000494:pharmacology / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D002316:Cardiotonic Agents; D018840:HSP70 Heat-Shock Proteins; D015850:Interleukin-6; D016209:Interleukin-8; D010936:Plant Extracts; C000600923:abnormal Savda Munziq; D008315:Malondialdehyde; D000069059:Atorvastatin; D013482:Superoxide Dismutase