title: Flexible modelling of simultaneously interval censored and truncated time-to-event data.
abstract: This paper deals with the analysis of data from a HET-CAM(VT) experiment. From a statistical perspective, such data yield many challenges. First of all, the data are typically time-to-event like data, which are at the same time interval censored and right truncated. In addition, one has to cope with overdispersion as well as clustering. Traditional analysis approaches ignore overdispersion and clustering and summarize the data into a continuous score that can be analysed using simple linear models. In this paper, a novel combined frailty model is developed that simultaneously captures all of the aforementioned statistical challenges posed by the data.
authors.affiliation: Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium.
authors.forename: Sammy
authors.initials: S
authors.lastname: Chebon
authors.affiliation: Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium.
authors.forename: Christel
authors.initials: C
authors.lastname: Faes
authors.affiliation: Janssen Pharmaceutica NV., Turnhoutseweg 30, Beerse, Belgium.
authors.forename: Ann De
authors.initials: AD
authors.lastname: Smedt
authors.affiliation: Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium.|Janssen Pharmaceutica NV., Turnhoutseweg 30, Beerse, Belgium.
authors.forename: Helena
authors.initials: H
authors.lastname: Geys
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002626:Chemistry, Pharmaceutical; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects*; D016000:Cluster Analysis; D003627:Data Interpretation, Statistical; D023381:Endpoint Determination / Q000706:statistics & numerical data*; D006801:Humans; D007509:Irritants / Q000008:administration & dosage / Q000633:toxicity*; D016015:Logistic Models; D012107:Research Design / Q000706:statistics & numerical data*; D018570:Risk Assessment; D013997:Time Factors; D018675:Toxicity Tests / Q000379:methods / Q000706:statistics & numerical data*
chemical_list: D007509:Irritants
keywords: HET-CAMVT; combined model; frailty modelling; interval censoring; truncation