title: Group VII Ethylene Response Factors Coordinate Oxygen and Nitric Oxide Signal Transduction and Stress Responses in Plants.
abstract: The group VII ethylene response factors (ERFVIIs) are plant-specific transcription factors that have emerged as important regulators of abiotic and biotic stress responses, in particular, low-oxygen stress. A defining feature of ERFVIIs is their conserved N-terminal domain, which renders them oxygen- and nitric oxide (NO)-dependent substrates of the N-end rule pathway of targeted proteolysis. In the presence of these gases, ERFVIIs are destabilized, whereas an absence of either permits their accumulation; ERFVIIs therefore coordinate plant homeostatic responses to oxygen availability and control a wide range of NO-mediated processes. ERFVIIs have a variety of context-specific protein and gene interaction partners, and also modulate gibberellin and abscisic acid signaling to regulate diverse developmental processes and stress responses. This update discusses recent advances in our understanding of ERFVII regulation and function, highlighting their role as central regulators of gaseous signal transduction at the interface of ethylene, oxygen, and NO signaling.
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaston B15 2TT, United Kingdom (D.J.G.); andDepartment of Plant and Crop Sciences, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom (J.V.C., S.B., G.P., G.M.M., M.J.H.) d.gibbs@bham.ac.uk michael.holdsworth@nottingham.ac.uk.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Gibbs
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaston B15 2TT, United Kingdom (D.J.G.); andDepartment of Plant and Crop Sciences, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom (J.V.C., S.B., G.P., G.M.M., M.J.H.).
authors.forename: Jorge Vicente
authors.initials: JV
authors.lastname: Conde
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaston B15 2TT, United Kingdom (D.J.G.); andDepartment of Plant and Crop Sciences, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom (J.V.C., S.B., G.P., G.M.M., M.J.H.).
authors.forename: Sophie
authors.initials: S
authors.lastname: Berckhan
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaston B15 2TT, United Kingdom (D.J.G.); andDepartment of Plant and Crop Sciences, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom (J.V.C., S.B., G.P., G.M.M., M.J.H.).
authors.forename: Geeta
authors.initials: G
authors.lastname: Prasad
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaston B15 2TT, United Kingdom (D.J.G.); andDepartment of Plant and Crop Sciences, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom (J.V.C., S.B., G.P., G.M.M., M.J.H.).
authors.forename: Guillermina M
authors.identifier: http://orcid.org/0000-0001-7716-4255
authors.initials: GM
authors.lastname: Mendiondo
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaston B15 2TT, United Kingdom (D.J.G.); andDepartment of Plant and Crop Sciences, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, United Kingdom (J.V.C., S.B., G.P., G.M.M., M.J.H.) d.gibbs@bham.ac.uk michael.holdsworth@nottingham.ac.uk.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Holdsworth
mesh_terms: D020816:Amino Acid Motifs; D005030:Ethylenes / Q000378:metabolism*; D018506:Gene Expression Regulation, Plant; D006706:Homeostasis; D009569:Nitric Oxide / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010802:Phylogeny; D010937:Plant Growth Regulators / Q000378:metabolism*; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D059748:Proteolysis; D015398:Signal Transduction; D013312:Stress, Physiological; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D005030:Ethylenes; D010937:Plant Growth Regulators; D010940:Plant Proteins; D014157:Transcription Factors; D009569:Nitric Oxide; C036216:ethylene; D010100:Oxygen