title: Bone histomorphometry after treatment with teriparatide (PTH 1-34) in a patient with adynamic bone disease subsequent to parathyroidectomy.
abstract: A 33-year-old male patient suffered from adynamic bone disease because of parathyroidectomy due to tertiary hyperparathyroidism. Histomorphometric analysis of bone biopsies taken before and 8 months after treatment with teriparatide (human parathyroid hormone 1-34 of recombinant DNA origin) for 18 months is demonstrated. A considerable increase in mineralized bone volume and also stimulated bone remodelling were detected after treatment with teriparatide. Although teriparatide is currently only licenced for treatment of severe osteoporosis, this case shows the potential therapeutic effect of this new drug to improve bone structure in a patient with adynamic bone disease.
authors.affiliation: Department of Internal Medicine III , Friedrich Schiller University of Jena.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Lehmann
authors.affiliation: Department of Internal Medicine III , Friedrich Schiller University of Jena.
authors.forename: Undine
authors.initials: U
authors.lastname: Ott
authors.affiliation: Dialysis Center and Nephrological Surgery, Gera , Germany.
authors.forename: Jörg
authors.initials: J
authors.lastname: Maiwald
authors.affiliation: Department of Internal Medicine III , Friedrich Schiller University of Jena.
authors.forename: Gunter
authors.initials: G
authors.lastname: Wolf
keywords: adynamic bone disease; end-stage renal disease; histomorphometry; teriparatide therapy