title: TFmiR: a web server for constructing and analyzing disease-specific transcription factor and miRNA co-regulatory networks.
abstract: TFmiR is a freely available web server for deep and integrative analysis of combinatorial regulatory interactions between transcription factors, microRNAs and target genes that are involved in disease pathogenesis. Since the inner workings of cells rely on the correct functioning of an enormously complex system of activating and repressing interactions that can be perturbed in many ways, TFmiR helps to better elucidate cellular mechanisms at the molecular level from a network perspective. The provided topological and functional analyses promote TFmiR as a reliable systems biology tool for researchers across the life science communities. TFmiR web server is accessible through the following URL: http://service.bioinformatik.uni-saarland.de/tfmir.
authors.affiliation: Center for Bioinformatics, Saarland University, 66041 Saarbrucken, Germany.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Hamed
authors.affiliation: Center for Bioinformatics, Saarland University, 66041 Saarbrucken, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Spaniol
authors.affiliation: Center for Bioinformatics, Saarland University, 66041 Saarbrucken, Germany.
authors.forename: Maryam
authors.initials: M
authors.lastname: Nazarieh
authors.affiliation: Center for Bioinformatics, Saarland University, 66041 Saarbrucken, Germany volkhard.helms@bioinformatik.uni-saarland.de.
authors.forename: Volkhard
authors.initials: V
authors.lastname: Helms
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics; D004194:Disease / Q000235:genetics*; D005260:Female; D053263:Gene Regulatory Networks; D006801:Humans; D020407:Internet; D035683:MicroRNAs / Q000378:metabolism*; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D035683:MicroRNAs; D014157:Transcription Factors