title: Efficient assembly of oligomannosides using the hydrophobically assisted switching phase method.
abstract: The hydrophobically assisted switching phase (HASP) method was applied in the assembly of oligomannosides. A new mannosyl donor with high reactivity was selected after a series of optimization studies, which was suitable for the synthesis of oligomannosides via the HASP method. The practicability of the HASP method towards the synthesis of branched oligosaccharides was explored and two branched penta-mannosides were assembled efficiently.
authors.affiliation: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. zjli@bjmu.edu.cn.
authors.forename: Shuai
authors.initials: S
authors.lastname: Meng
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.forename: Dong
authors.initials: D
authors.lastname: Han
authors.forename: Lin-Na
authors.initials: LN
authors.lastname: Wang
authors.forename: Shao-Geng
authors.initials: SG
authors.lastname: Tang
authors.forename: Xiang-Bao
authors.initials: XB
authors.lastname: Meng
authors.forename: Zhong-Jun
authors.initials: ZJ
authors.lastname: Li
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods; D006031:Glycosylation; D057927:Hydrophobic and Hydrophilic Interactions; D008362:Mannosides / Q000138:chemical synthesis* / Q000737:chemistry; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D008362:Mannosides; D009844:Oligosaccharides; C028569:oligomannoside