title: Evaluation of the swelling behaviour of iota-carrageenan in monolithic matrix tablets.
abstract: The swelling properties of monolithic matrix tablets containing iota-carrageenan were studied at different pH values, with measurements of the swelling force and characterization of the profile of the swelling curve. The swelling force meter was linked to a PC by an RS232 cable and the measured data were evaluated with self-developed software. The monitor displayed the swelling force vs. time curve with the important parameters, which could be fitted with an Analysis menu. In the case of iota-carrageenan matrix tablets, it was concluded that the pH and the pressure did not influence the swelling process, and the first section of the swelling curve could be fitted by the Korsmeyer-Peppas equation.
authors.affiliation: Department of Applied Informatics, University of Szeged, Boldogasszony sgt. 6, H-6725 Szeged, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Kelemen
authors.affiliation: Central Clinical Pharmacy, University of Debrecen, Nagyerdei krt 98, H-4032 Debrecen, Hungary.
authors.forename: Gyula
authors.initials: G
authors.lastname: Buchholcz
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
authors.forename: Tamás
authors.initials: T
authors.lastname: Sovány
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary. Electronic address: klara.hodi@pharm.u-szeged.hu.
authors.forename: Klára
authors.initials: K
authors.lastname: Pintye-Hódi
mesh_terms: D002351:Carrageenan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation / Q000502:physiology; D005079:Excipients / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D011312:Pressure; D012984:Software; D013607:Tablets / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D002351:Carrageenan
keywords: Biodegradable polymer; Biomaterials; Iota-carrageenan; Monolithic matrix tablet; Swelling force meter; Swelling kinetics