title: Phage Therapy: a Step Forward in the Treatment of Pseudomonas aeruginosa Infections.
abstract: Antimicrobial resistance constitutes one of the major worldwide public health concerns. Bacteria are becoming resistant to the vast majority of antibiotics, and nowadays, a common infection can be fatal. To address this situation, the use of phages for the treatment of bacterial infections has been extensively studied as an alternative therapeutic strategy. Since Pseudomonas aeruginosa is one of the most common causes of health care-associated infections, many studies have reported the in vitro and in vivo antibacterial efficacy of phage therapy against this bacterium. This review collects data of all the P. aeruginosa phages sequenced to date, providing a better understanding about their biodiversity. This review further addresses the in vitro and in vivo results obtained by using phages to treat or prevent P. aeruginosa infections as well as the major hurdles associated with this therapy.
authors.affiliation: CEB-Centre of Biological Engineering, LIBRO-Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Braga, Portugal.
authors.forename: Diana P
authors.initials: DP
authors.lastname: Pires
authors.affiliation: CEB-Centre of Biological Engineering, LIBRO-Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Braga, Portugal.
authors.forename: Diana
authors.initials: D
authors.lastname: Vilas Boas
authors.affiliation: CEB-Centre of Biological Engineering, LIBRO-Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Braga, Portugal.
authors.forename: Sanna
authors.initials: S
authors.lastname: Sillankorva
authors.affiliation: CEB-Centre of Biological Engineering, LIBRO-Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, Braga, Portugal jazeredo@deb.uminho.pt.
authors.forename: Joana
authors.initials: J
authors.lastname: Azeredo
mesh_terms: D000818:Animals; D001691:Biological Therapy; D004195:Disease Models, Animal; D006801:Humans; D011552:Pseudomonas Infections / Q000382:microbiology / Q000628:therapy*; D017105:Pseudomonas Phages / Q000502:physiology*; D011550:Pseudomonas aeruginosa / Q000502:physiology / Q000821:virology*