title: Al(OH)3 facilitated synthesis of water-soluble, magnetic, radiolabelled and fluorescent hydroxyapatite nanoparticles.
abstract: Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)3-stabilised MnFe2O4 or Fe3O4 nanoparticles as precursors. They were readily and efficiently radiolabelled with (18)F. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with (64)Cu.
authors.affiliation: King's College London, Division of Imaging Sciences and Biomedical Engineering, 4th Floor of Lambeth wing, St Thomas Hospital, London SE1 7EH, UK. philip.blower@kcl.ac.uk mark.a.green@kcl.ac.uk.
authors.forename: X
authors.initials: X
authors.lastname: Cui
authors.forename: M A
authors.initials: MA
authors.lastname: Green
authors.forename: P J
authors.initials: PJ
authors.lastname: Blower
authors.forename: D
authors.initials: D
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Yan
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: K
authors.initials: K
authors.lastname: Djanashvili
authors.forename: D
authors.initials: D
authors.lastname: Mathe
authors.forename: D S
authors.initials: DS
authors.lastname: Veres
authors.forename: K
authors.initials: K
authors.lastname: Szigeti
mesh_terms: D000536:Aluminum Hydroxide / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D005462:Fluorine Radioisotopes; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D005462:Fluorine Radioisotopes; D014867:Water; D000536:Aluminum Hydroxide; D017886:Durapatite