title: Combination of intracerebral haemorrhage and familial hypercholesterolemia in the acute hospital setting--a challenge for statin treatment?
abstract: It is estimated that worldwide, around 35 million people have familial hypercholesterolemia (FH). Thus, patients affected by the combination of FH and acute intracerebral hemorrhage (ICH) are not exceptional and neurologists should be prepared to encounter them. Despite a recent finding of beneficial association between statin use during hospitalization and improved outcomes, the increased risk of recurrent ICH in the long term may make clinicians avoid statins in patients with a history of ICH. However, discontinuing statins in patients with FH worsens cardiovascular outcomes and even increases all-cause mortality. Accordingly, the continuing statin treatment in an FH patient with an acute ICH is advisable.
authors.affiliation: Medical Health Center Mehiläinen Airport, Vantaa, Finland and Finnish Institute of Occupational Health (FIOH), Lappeenranta, Finland.
authors.forename: Alpo
authors.initials: A
authors.lastname: Vuorio
authors.affiliation: Department of Neurology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Kaste
authors.affiliation: Wihuri Research Institute, Helsinki, Finland.
authors.forename: Petri T
authors.initials: PT
authors.lastname: Kovanen
mesh_terms: D000367:Age Factors; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000188:drug therapy*; D006760:Hospitalization; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006938:Hyperlipoproteinemia Type II / Q000150:complications*; D017410:Practice Guidelines as Topic
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: atherosclerosis; familial hypercholesterolemia; intracerebral haemorrhage; myocardial infarction; statins; stroke