title: Fish Oil and Olive Oil Supplementation in Late Pregnancy and Lactation Differentially Affect Oxidative Stress and Inflammation in Sows and Piglets.
abstract: This study was conducted to compare the effects of fish oil and olive oil supplementation in late pregnancy and during lactation on oxidative stress and inflammation in sows and their piglets. A total of 24 sows were fed a basal diet supplemented with additional corn starch (CON), fish oil (FO) or olive oil (OO). Sows fed an OO diet during late gestation had a higher piglet birth weight compared with CON-fed and FO-fed sows (P < 0.05). Furthermore, sows from the OO group had a higher milk fat content than sows from CON and FO groups, and a lower pre-weaning mortality of piglets was observed in the OO group (P < 0.05). Maternal FO supplementation resulted in increased malondialdehyde concentration in sow plasma, colostrum, milk and piglet plasma than in CON and OO groups (P < 0.05). However, an increased total antioxidant capacity (T-ACC) and activities of glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) were also observed in the FO group (P < 0.05). Sows fed an OO diet had significantly decreased interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations in milk compared with CON and FO fed sows (P < 0.05). Moreover, lower plasma IL-1β and TNF-α levels were observed in piglets from the OO group compared with the CON group (P < 0.05). Collectively, these results suggest that an OO diet is most beneficial in late gestation and during lactation in sows. However, FO increases the susceptibility to oxidative stress in sows and piglets.
authors.affiliation: Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Agriculture of China, Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an, 625014, Sichuan, China, 1366885382@qq.com.
authors.forename: Yong
authors.initials: Y
authors.lastname: Shen
authors.forename: Haifeng
authors.initials: H
authors.lastname: Wan
authors.forename: Jiatao
authors.initials: J
authors.lastname: Zhu
authors.forename: Zhengfeng
authors.initials: Z
authors.lastname: Fang
authors.forename: Lianqiang
authors.initials: L
authors.lastname: Che
authors.forename: Shengyu
authors.initials: S
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Lin
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: De
authors.initials: D
authors.lastname: Wu
mesh_terms: D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000833:Animals, Suckling / Q000254:growth & development / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D004032:Diet / Q000662:veterinary; D019587:Dietary Supplements / Q000032:analysis; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage* / Q000494:pharmacology; D007774:Lactation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D039382:Maternal Nutritional Physiological Phenomena; D000069463:Olive Oil / Q000008:administration & dosage* / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D011247:Pregnancy; D013552:Swine / Q000254:growth & development / Q000276:immunology*
chemical_list: D016207:Cytokines; D005395:Fish Oils; D000069463:Olive Oil; D008315:Malondialdehyde