title: Nazumazoles A-C, Cyclic Pentapeptides Dimerized through a Disulfide Bond from the Marine Sponge Theonella swinhoei.
abstract: A mixture of nazumazoles A-C (1-3) was purified from the extract of the marine sponge Theonella swinhoei. The mixture was eluted as an extraordinarily broad peak in the reversed-phase HPLC. The structures of nazumazoles were determined by interpretation of the NMR data and chemical degradations. Nazumazoles contain one residue each of alanine-derived oxazole and α-keto-β-amino acid residue. Nazumazoles exhibited cytotoxicity against P388 cells.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Kazuya
authors.initials: K
authors.lastname: Fukuhara
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takada
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Okada
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
mesh_terms: D000818:Animals; D019281:Dimerization; D004220:Disulfides / Q000737:chemistry*; D008968:Molecular Conformation; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D047232:Theonella / Q000737:chemistry*
chemical_list: D004220:Disulfides; D010080:Oxazoles; D010456:Peptides, Cyclic; C000601935:nazumazole A; C000601936:nazumazole B; C000601937:nazumazole C