title: Why Optogenetics Needs in Vivo Neurochemistry.
abstract: In neuroscience, the consequences of optogenetic manipulation are often studied using in vivo electrophysiology and by observing behavioral changes induced by light stimulation in genetically targeted rodents. In contrast, reports on the in vivo neurochemical effects of optogenetic stimulation are scarce despite the improving quality of analytical techniques available to monitor biochemical compounds involved in neurotransmission. This intriguing lack of neurochemical information suggests the existence of unknown or misunderstood factors hampering the expected rise of a novel specialty putatively be termed "neurochemical optogenetics".
authors.affiliation: †INSERM U1028; CNRS UMR5292; Université Lyon 1; Lyon Neuroscience Research Center, NeuroDialyTics Unit, Lyon, F-69000, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Parrot
authors.affiliation: ‡CNRS UMR5292; INSERM U1028; Université Lyon 1; Lyon Neuroscience Research Center, BioRaN team, Lyon, F-69000, France.
authors.forename: Luc
authors.initials: L
authors.lastname: Denoroy
authors.affiliation: †INSERM U1028; CNRS UMR5292; Université Lyon 1; Lyon Neuroscience Research Center, NeuroDialyTics Unit, Lyon, F-69000, France.|§Laboratory of Neurobiology, Lyon University Hospitals, Bron, F-69500, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Renaud
authors.affiliation: ∥INSERM U1028; CNRS UMR5292; Université Lyon 1; Lyon Neuroscience Research Center, Functional NeuroGenetics and Optogenetics, NGFO Unit, Lyon, F-69000, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Benetollo
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D009448:Neurochemistry / Q000379:methods*; D009474:Neurons / Q000378:metabolism; D062308:Optogenetics / Q000379:methods*; D009435:Synaptic Transmission / Q000502:physiology
keywords: Optogenetics; in vivo neurochemistry; microdialysis; neurotransmitters; voltammetry