title: Autophagy in endocrine tumors.
abstract: Autophagy is an important intracellular process involving the degradation of cytoplasmic components. It is involved in both physiological and pathological conditions, including cancer. The role of autophagy in cancer is described as a 'double-edged sword,' a term that reflects its known participation in tumor suppression, tumor survival and tumor cell proliferation. Available research regarding autophagy in endocrine cancer supports this concept. Autophagy shows promise as a novel therapeutic target in different types of endocrine cancer, inhibiting or increasing treatment efficacy in a context- and cell-type-dependent manner. At present, however, there is very little research concerning autophagy in endocrine tumors. No research was reported connecting autophagy to some of the tumors of the endocrine glands such as the pancreas and ovary. This review aims to elucidate the roles of autophagy in different types of endocrine cancer and highlight the need for increased research in the field.
authors.affiliation: Division of NeurosurgeryDepartment of SurgeryDivision of PathologyDepartment of Laboratory Medicine, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8 CanadaDepartment of NeurosurgeryHospital Pablo Tobon Uribe and Clínica Medellin, Medellin, Colombia.
authors.forename: Andrea
authors.initials: A
authors.lastname: Weckman
authors.affiliation: Division of NeurosurgeryDepartment of SurgeryDivision of PathologyDepartment of Laboratory Medicine, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8 CanadaDepartment of NeurosurgeryHospital Pablo Tobon Uribe and Clínica Medellin, Medellin, Colombia rotondf@smh.ca.
authors.forename: Fabio
authors.initials: F
authors.lastname: Rotondo
authors.affiliation: Division of NeurosurgeryDepartment of SurgeryDivision of PathologyDepartment of Laboratory Medicine, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8 CanadaDepartment of NeurosurgeryHospital Pablo Tobon Uribe and Clínica Medellin, Medellin, Colombia.
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Ieva
authors.affiliation: Division of NeurosurgeryDepartment of SurgeryDivision of PathologyDepartment of Laboratory Medicine, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8 CanadaDepartment of NeurosurgeryHospital Pablo Tobon Uribe and Clínica Medellin, Medellin, Colombia.
authors.forename: Luis V
authors.initials: LV
authors.lastname: Syro
authors.affiliation: Division of NeurosurgeryDepartment of SurgeryDivision of PathologyDepartment of Laboratory Medicine, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8 CanadaDepartment of NeurosurgeryHospital Pablo Tobon Uribe and Clínica Medellin, Medellin, Colombia.
authors.forename: Henriett
authors.initials: H
authors.lastname: Butz
authors.affiliation: Division of NeurosurgeryDepartment of SurgeryDivision of PathologyDepartment of Laboratory Medicine, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8 CanadaDepartment of NeurosurgeryHospital Pablo Tobon Uribe and Clínica Medellin, Medellin, Colombia.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Cusimano
authors.affiliation: Division of NeurosurgeryDepartment of SurgeryDivision of PathologyDepartment of Laboratory Medicine, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8 CanadaDepartment of NeurosurgeryHospital Pablo Tobon Uribe and Clínica Medellin, Medellin, Colombia.
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs
mesh_terms: D000818:Animals; D001343:Autophagy; D004701:Endocrine Gland Neoplasms; D006801:Humans
keywords: autophagy; autophagy modulation; endocrine disease; neoplasia; therapeutic potential