title: Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen.
abstract: A subset of CD1c-restricted T lymphocytes exhibits strong reactivity against leukemia cells. These T cells recognize methyl-lysophosphatidic acid (mLPA), a novel lipid antigen produced by acute leukemia cells. Considering that CD1c-restricted T cells display efficacious anti-leukemia activities in a mouse model, this lipid antigen thus represents a novel target in the immunotherapy of hematological malignancies.
authors.affiliation: Experimental Immunology, Department of Biomedicine; University Hospital Basel ; Basel, Switzerland.
authors.forename: Marco
authors.initials: M
authors.lastname: Lepore
authors.affiliation: Experimental Immunology Unit; Division of Immunology, Transplantation and Infectious Diseases; San Raffaele Scientific Institute ; Milano, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: de Lalla
authors.affiliation: Experimental Immunology, Department of Biomedicine; University Hospital Basel ; Basel, Switzerland ; Singapore Immunology Network (SIgN); Agency for Science, Technology, and Research ; Singapore.
authors.forename: Lucia
authors.initials: L
authors.lastname: Mori
authors.affiliation: Experimental Immunology Unit; Division of Immunology, Transplantation and Infectious Diseases; San Raffaele Scientific Institute ; Milano, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Dellabona
authors.affiliation: Experimental Immunology, Department of Biomedicine; University Hospital Basel ; Basel, Switzerland ; Singapore Immunology Network (SIgN); Agency for Science, Technology, and Research ; Singapore.
authors.forename: Gennaro
authors.initials: G
authors.lastname: De Libero
authors.affiliation: Experimental Immunology Unit; Division of Immunology, Transplantation and Infectious Diseases; San Raffaele Scientific Institute ; Milano, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Casorati
keywords: CD1; autoreactivity; immunesurveillance; immunotherapy; leukemia; lipid antigens