title: Deep-sea hydrothermal vent bacteria related to human pathogenic Vibrio species.
abstract: Vibrio species are both ubiquitous and abundant in marine coastal waters, estuaries, ocean sediment, and aquaculture settings worldwide. We report here the isolation, characterization, and genome sequence of a novel Vibrio species, Vibrio antiquarius, isolated from a mesophilic bacterial community associated with hydrothermal vents located along the East Pacific Rise, near the southwest coast of Mexico. Genomic and phenotypic analysis revealed V. antiquarius is closely related to pathogenic Vibrio species, namely Vibrio alginolyticus, Vibrio parahaemolyticus, Vibrio harveyi, and Vibrio vulnificus, but sufficiently divergent to warrant a separate species status. The V. antiquarius genome encodes genes and operons with ecological functions relevant to the environment conditions of the deep sea and also harbors factors known to be involved in human disease caused by freshwater, coastal, and brackish water vibrios. The presence of virulence factors in this deep-sea Vibrio species suggests a far more fundamental role of these factors for their bacterial host. Comparative genomics revealed a variety of genomic events that may have provided an important driving force in V. antiquarius evolution, facilitating response to environmental conditions of the deep sea.
authors.affiliation: Maryland Pathogen Research Institute, CosmosID, College Park, MD 20742; University of Maryland Institute for Advanced Computer Studies, and.
authors.forename: Nur A
authors.initials: NA
authors.lastname: Hasan
authors.affiliation: Maryland Pathogen Research Institute, University of Maryland Institute for Advanced Computer Studies, and.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Grim
authors.affiliation: Environmental Health Science, College of Public Health, University of Georgia, Athens, GA 30602;
authors.forename: Erin K
authors.initials: EK
authors.lastname: Lipp
authors.affiliation: Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, CEP 05508-900 São Paulo, Brazil;
authors.forename: Irma N G
authors.initials: IN
authors.lastname: Rivera
authors.affiliation: School of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul 151-742, Republic of Korea;
authors.forename: Jongsik
authors.initials: J
authors.lastname: Chun
authors.affiliation: Maryland Pathogen Research Institute.
authors.forename: Bradd J
authors.initials: BJ
authors.lastname: Haley
authors.affiliation: Maryland Pathogen Research Institute.
authors.forename: Elisa
authors.initials: E
authors.lastname: Taviani
authors.affiliation: Maryland Pathogen Research Institute, CosmosID, College Park, MD 20742;
authors.forename: Seon Young
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Department of Microbiology, University of Dhaka, Dhaka-1000, Bangladesh;
authors.forename: Mozammel
authors.initials: M
authors.lastname: Hoq
authors.affiliation: Genome Science Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545;
authors.forename: A Christine
authors.initials: AC
authors.lastname: Munk
authors.affiliation: Genome Science Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545;
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Brettin
authors.affiliation: Genome Science Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545;
authors.forename: David
authors.initials: D
authors.lastname: Bruce
authors.affiliation: Genome Science Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545;
authors.forename: Jean F
authors.initials: JF
authors.lastname: Challacombe
authors.affiliation: Genome Science Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545;
authors.forename: J Chris
authors.initials: JC
authors.lastname: Detter
authors.affiliation: Genome Science Group, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545;
authors.forename: Cliff S
authors.initials: CS
authors.lastname: Han
authors.affiliation: University of California Davis Genome Center, Davis, CA 95616;
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Eisen
authors.affiliation: Maryland Pathogen Research Institute, Institute for Applied Environmental Health, University of Maryland, College Park, MD 20742;
authors.forename: Anwar
authors.initials: A
authors.lastname: Huq
authors.affiliation: Maryland Pathogen Research Institute, CosmosID, College Park, MD 20742; University of Maryland Institute for Advanced Computer Studies, and Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205 rcolwell@umiacs.umd.edu.
authors.forename: Rita R
authors.initials: RR
authors.lastname: Colwell
mesh_terms: D019143:Evolution, Molecular; D016680:Genome, Bacterial; D006801:Humans; D060086:Hydrothermal Vents / Q000382:microbiology*; D010802:Phylogeny; D012329:RNA, Bacterial / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012623:Seawater / Q000382:microbiology; D013045:Species Specificity; D014733:Vibrio / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics
chemical_list: D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S
keywords: EX25; Vibrio; genomics; hydrothermal vent