title: KIT gene mutations in gastrointestinal stromal tumor.
abstract: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. It arises in the stomach, small intestine, colon, rectum and esophagus. KIT gene mutation is a feature of GIST, in addition to PDGFRA gene mutation. KIT gene mutations have been observed to be involved in the development of GIST, its recurrence after surgery and chemotherapy resistance in GIST. Exons 13, 17, 9, and mainly exon 11 are concerned in these biological behaviors of GIST. In this review, we will discuss on the involvement of KIT gene mutations in the tumorigenesis, recurrence and chemotherapeutic resistance of GIST.
authors.forename: Weiming
authors.initials: W
authors.lastname: Kang
authors.forename: Changzhen
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, Peking Union Medical College Hospital, CAMS and PUMC, No. 1 Shuai Fu Yuan, Dongcheng District, Beijing 100730, China, yu_jch@yeah.net.
authors.forename: JianChun
authors.initials: J
authors.lastname: Yu
authors.forename: Xin
authors.initials: X
authors.lastname: Ye
authors.forename: ZhiQiang
authors.initials: Z
authors.lastname: Ma
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009154:Mutation; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D012008:Recurrence
chemical_list: D000970:Antineoplastic Agents; D019009:Proto-Oncogene Proteins c-kit