title: The impact of L5 dorsal root ganglion degeneration and Adamkiewicz artery vasospasm on descending colon dilatation following spinal subarachnoid hemorrhage: An experimental study; first report.
abstract: BACKGROUND
  Somato-sensitive innervation of bowels are maintained by lower segments of spinal cord and the blood supply of the lower spinal cord is heavily dependent on Adamkiewicz artery. Although bowel problems are sometimes seen in subarachnoid hemorrhage neither Adamkiewicz artery spasm nor spinal cord ischemia has not been elucidated as a cause of bowel dilatation so far.
  
  
  OBJECTIVE
  The goal of this study was to study the effects Adamkiewicz artery (AKA) vasospasm in lumbar subarachnoid hemorrhage (SAH) on bowel dilatation severity.
  
  
  METHODS
  An experimental rabbit study.
  
  
  METHODS
  The study was conducted on 25 rabbits, which were randomly divided into three groups: Spinal SAH (N = 13), serum saline (SS) (SS; N = 7) and control (N = 5) groups. Experimental spinal SAH was performed. After 21 days, volume values of descending parts of large bowels and degenerated neuron density of L5DRG were analyzed.
  
  
  METHODS
  Statistical analysis was performed using the PASW Statistics 18.0 for Windows (SPSS Inc., Chicago, Illinois). Two-tailed t-test and Mann-Whitney U-tests were used. The statistical significance was set at P < 0.05.
  
  
  RESULTS
  The mean volume of imaginary descending colons was estimated as 93 ± 12 cm(3) in the control group and 121 ± 26 cm(3) in the SS group and 176 ± 49 cm(3) in SAH group. Volume augmentations of the descending colons and degenerated neuron density L5DRG were significantly different between the SAH and other two groups (P < 0.05).
  
  
  CONCLUSIONS
  An inverse relationship between the living neuronal density of the L5DRG and the volume of imaginary descending colon values was occurred. Our findings will aid in the planning of future experimental studies and determining the clinical relevance on such studies.
authors.affiliation: Erzurum Regional Research and Education Hospital Family Physician, Erzurum, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.affiliation: Department of Neurosurgery, Medical Faculty, Recep Tayyip Erdogan University, Rize, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Kanat
authors.affiliation: Department of Neurosurgery, Medical Faculty, Ataturk University, Erzurum, Turkey.
authors.forename: Mehmet Dumlu
authors.initials: MD
authors.lastname: Aydin
authors.affiliation: Department of Neurosurgery, Erzurum Regional Research and Education Hospital Family Physician, Erzurum, Turkey.
authors.forename: Coskun
authors.initials: C
authors.lastname: Yolas
authors.affiliation: Department of Pathology, Erzurum Regional Research and Education Hospital Family Physician, Erzurum, Turkey.
authors.forename: Mehmet Esref
authors.initials: ME
authors.lastname: Kabalar
authors.affiliation: Department of Pathology, Medical Faculty, Ataturk University, Erzurum, Turkey.
authors.forename: Betul
authors.initials: B
authors.lastname: Gundogdu
authors.affiliation: Department of Pathology, Giresun University, Medical Faculty, Giresun, Turkey.
authors.forename: Aslihan
authors.initials: A
authors.lastname: Duman
authors.affiliation: Department of Internal Medicine, Atatürk Training and Research Hospital, Ankara, Turkey.
authors.forename: Ilyas Ferit
authors.initials: IF
authors.lastname: Kanat
authors.affiliation: Department of Pathology, Medical Faculty, Ataturk University, Erzurum, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Gundogdu
keywords: Adamkiewicz artery; bowel dilatation; dorsal root ganglion; lumbar; spine; subarachnoid hemorrhage; vasospasm