title: Human papillomavirus type 16 sequence variation in concurrent vulvar and penile carcinoma in a married couple.
abstract: We encountered an elderly married couple with concurrent vulvar and penile carcinoma with an Asian variant of human papillomavirus type 16. Asian variants might have an elevated risk of concurrent external genital carcinomas of a male and a female, and analysis of human papillomavirus variants might be important to understand the mechanism of carcinogenesis.
authors.affiliation: From the *Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan; †Division of Pathology, Hokkaido Cancer Center, Shiroishi-ku, Sapporo, Japan; and ‡Department of Gynecology, Hokkaido Cancer Society, Higashi-ku, Sapporo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Mitamura
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Watari
authors.forename: Katsushige
authors.initials: K
authors.lastname: Yamashiro
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kato
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Hosaka
authors.forename: Chisa
authors.initials: C
authors.lastname: Shimada
authors.forename: Shun
authors.initials: S
authors.lastname: Fukumoto
authors.forename: Kiwamu
authors.initials: K
authors.lastname: Noshiro
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sasaki
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sakuragi
mesh_terms: D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D014644:Genetic Variation; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000235:genetics / Q000473:pathology*; D010412:Penile Neoplasms / Q000235:genetics / Q000473:pathology* / Q000821:virology; D016133:Polymerase Chain Reaction; D018454:Spouses; D014846:Vulvar Neoplasms / Q000235:genetics / Q000473:pathology* / Q000821:virology
chemical_list: D004279:DNA, Viral