title: Left ventricular remodeling and diastolic function in chronic hypertensive pregnant women.
abstract: Hypertension during pregnancy is a problem that impacts maternal morbidity and mortality. Dyspnea and edema are common symptoms, often secondary to physiological changes, but may raise doubts as to ventricular dysfunction.
  
  
  OBJECTIVE
  To evaluate the ventricular geometry pattern and diastolic function in chronic hypertensive pregnant women (HPW).
  
  
  METHODS
  Prospective, cross-sectional study on 62 pregnant women over a 29-month period, from March 2009 to July 2011, in Brazil was done. Thirty-one HPWs and 31 normotensive pregnant women (NPW) underwent clinical and cardiovascular evaluations, and were subjected to transthoracic echocardiogram.
  
  
  RESULTS
  LV mass (HPW: 220.9 ± 43.3 vs. NPW: 192.9 ± 39.8 g, p = 0.01), posterior wall thickness (HPW: 9.9 ± 1.1 vs. NPW: 9.2 ± 0.9 mm, p = 0.005), mitral flow A wave velocity (HPW: 0.60 ± 0.16 vs. NPW: 0.52 ± 0.10 m/s, p = 0.02), tissue Doppler A' wave velocity (HPW: 10 ± 2 vs. NPW: 8.9 ± 1cm/s, p=0.02), and E/E' ratio (HPW: 6.8 ± 2.2 vs. NPW: 5.5 ± 1.6, p = 0.01) were higher in HPWs. Septal and lateral walls E' wave velocities (HPW: 13 ± 2 vs. NPW: 15 ± 3 cm/s, p=0.001), and E'/A' ratio (HPW: 1.26 ± 0.38 vs. NPW: 1.77 ± 0.49, p = 0.00003) were lower in HPWs. There was a positive linear correlation between body mass index (BMI) and ventricular mass, A wave, systolic, diastolic blood pressures, and a negative correlation between BMI, E' wave and E'/A' ratio.
  
  
  CONCLUSIONS
  Ventricular remodeling showed a direct relationship with body weight, and both groups showed a predominant pattern of eccentric ventricular hypertrophy. The LV diastolic function was abnormal in HPWs.
authors.affiliation: UNIFESO - Centro Universitário Serra dos Órgãos, Av. Alberto Torres 111-Alto, Teresópolis, RJ CEP 25964-004, Brazil. Electronic address: marcolan@cardiol.br.
authors.forename: Cristina Maria
authors.initials: CM
authors.lastname: Marcolan Quitete
authors.affiliation: UNIFESO - Centro Universitário Serra dos Órgãos, Av. Alberto Torres 111-Alto, Teresópolis, RJ CEP 25964-004, Brazil.
authors.forename: Aline
authors.initials: A
authors.lastname: Marcolan Salvany
authors.affiliation: Curso de Pós-Graduação em Ciências Cardiovasculares - Universidade Federal Fluminense (UFF), HUAP, Rua Marques do Paraná 303-Centro, Niterói, RJ CEP 24033-900, Brazil.
authors.forename: Wolney
authors.initials: W
authors.lastname: de Andrade Martins
authors.affiliation: Curso de Pós-Graduação em Ciências Cardiovasculares - Universidade Federal Fluminense (UFF), HUAP, Rua Marques do Paraná 303-Centro, Niterói, RJ CEP 24033-900, Brazil.
authors.forename: Evandro Tinoco
authors.initials: ET
authors.lastname: Mesquita
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000503:physiopathology*; D015588:Observer Variation; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000502:physiology; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*; D020257:Ventricular Remodeling / Q000502:physiology*
keywords: Hypertension; Left ventricular function; Pregnancy; Transthoracic echocardiogram