title: Tuning noise in gene expression.
abstract: The relative contribution of promoter architecture and the associated chromatin environment in regulating gene expression noise has remained elusive. In their recent work, Arkin, Schaffer and colleagues (Dey et al, 2015) show that mean expression and noise for a given promoter at different genomic loci are uncorrelated and influenced by the local chromatin environment.
authors.affiliation: Public Health Research Institute, Rutgers University, Newark, NJ, USA.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Tyagi
mesh_terms: D044127:Epigenesis, Genetic; D006801:Humans; D011506:Proteins / Q000032:analysis*; D012333:RNA, Messenger / Q000032:analysis*
chemical_list: D011506:Proteins; D012333:RNA, Messenger