title: Situational aldehyde dehydrogenase expression by regulatory T cells may explain the contextual duality of cyclophosphamide as both a pro-inflammatory and tolerogenic agent.
abstract: In two recent publications, we demonstrated that after allogeneic stimulation, regulatory T cells (Tregs) increase expression of aldehyde dehydrogenase (ALDH), the majorin vivomechanism of cyclophosphamide detoxification, thereby becoming cyclophosphamide resistant. Differential ALDH expression may explain why cyclophosphamide has pro- and anti-inflammatory effects that are temporally and contextually dependent.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine ; Baltimore, MD, USA.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Kanakry
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine ; Baltimore, MD, USA.
authors.forename: Sudipto
authors.initials: S
authors.lastname: Ganguly
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center; The Johns Hopkins University School of Medicine ; Baltimore, MD, USA.
authors.forename: Leo
authors.initials: L
authors.lastname: Luznik
keywords: aldehyde dehydrogenase, ALDH, allogeneic, BMT, cyclophosphamide, post-transplantation cyclophosphamide, regulatory T cell, tolerance, Treg