title: Comparative outcomes of severe obstructive sleep apnea in pediatric patients with Trisomy 21.
abstract: OBJECTIVE
  To analyze the outcomes of severe obstructive sleep apnea (OSA) in pediatric patients with Trisomy 21 compared with non-syndromic patients.
  
  
  METHODS
  A retrospective chart review was performed for patients with a diagnosis of severe obstructive sleep apnea, (defined as, Apnea-Hypopnea index (AHI) of ≥ 10) in a tertiary children's hospital. Data were analyzed for subjective and objective outcomes along with perioperative care and health care utilization. Patients with Trisomy 21 were compared with non-syndromic patients.
  
  
  RESULTS
  A total of 230 patients with severe OSA were included in the study. Eighteen of these patients had Trisomy 21. Adenotonsillectomy was the most common surgical intervention in both groups. There was no statistical difference in the preoperative AHI between groups. Post treatment AHI in the Trisomy 21 group changed from an average of 26.6 to an average of 11.6 as compared with 24.5 to 3.6 in the non-syndromic group. The average perioperative hospital stay was 3.8 days in Trisomy 21 group compared to 1.7 days for the non-syndromic group (p < 0.001, Mann-Whitney U test). Complete resolution was seen in 35% of the Trisomy 21 group versus 75% in the non-syndromic group.
  
  
  CONCLUSIONS
  A majority of Trisomy 21 patients with severe OSA had residual symptoms following surgical intervention. There is also an increased risk of post-operative airway intervention and increased length of hospital stay in these patients.
authors.affiliation: Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Children's Hospital of Pittsburgh Department of Pediatric Otolaryngology, Pittsburgh, PA, USA.
authors.forename: Prasad John
authors.initials: PJ
authors.lastname: Thottam
authors.affiliation: Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Sumita
authors.initials: S
authors.lastname: Trivedi
authors.affiliation: Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Children's Hospital of Pittsburgh Department of Pediatric Otolaryngology, Pittsburgh, PA, USA.
authors.forename: Bianca
authors.initials: B
authors.lastname: Siegel
authors.affiliation: University of Pittsburgh Physician Services Division, Pediatric Otolaryngology, Pittsburgh, PA, USA.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Williams
authors.affiliation: Children's Hospital of Pittsburgh Department of Pediatric Otolaryngology, Pittsburgh, PA, USA. Electronic address: deepak.Mehta@chp.edu.
authors.forename: Deepak
authors.initials: D
authors.lastname: Mehta
mesh_terms: D000233:Adenoidectomy; D016022:Case-Control Studies; D002648:Child; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D017286:Polysomnography; D011182:Postoperative Care; D012189:Retrospective Studies; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000601:surgery*; D014068:Tonsillectomy; D016896:Treatment Outcome
keywords: Adenotonsillectomy; Down's syndrome; Obstructive sleep apnea; Post-operative complications; Tonsillectomy; Trisomy 21