title: DNA hydrogel delivery vehicle for light-triggered and synergistic cancer therapy.
abstract: A DNA hydrogel is reported as a delivery vehicle for gold nanorods and doxorubicin. The two photothermal and chemo cancer agents were co-loaded using electrostatic and DNA binding interactions, respectively. Light-triggered and highly synergistic combination cancer therapy was demonstrated in cellular and animal models.
authors.affiliation: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science & Technology (POSTECH), San 31, Hyojadong, Pohang 790-784, Korea. sungjee@postech.ac.kr.
authors.forename: Jaejung
authors.initials: J
authors.lastname: Song
authors.forename: Kyuhyun
authors.initials: K
authors.lastname: Im
authors.forename: Sekyu
authors.initials: S
authors.lastname: Hwang
authors.forename: Jaehyun
authors.initials: J
authors.lastname: Hur
authors.forename: Jutaek
authors.initials: J
authors.lastname: Nam
authors.forename: G-One
authors.initials: GO
authors.lastname: Ahn
authors.forename: Sungwoo
authors.initials: S
authors.lastname: Hwang
authors.forename: Sungjee
authors.initials: S
authors.lastname: Kim
authors.forename: Nokyoung
authors.initials: N
authors.lastname: Park
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage; D004337:Drug Carriers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D008027:Light; D051379:Mice; D043942:Nanotubes / Q000737:chemistry / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy*; D055672:Static Electricity
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006046:Gold; D004317:Doxorubicin; D004247:DNA