title: A Sporadic Small Jejunal GIST Presenting with Acute Lower Gastrointestinal Hemorrhage: A Review of the Literature and Management Guidelines.
abstract: Gastrointestinal stromal tumors (GISTs) represent the majority of primary nonepithelial neoplasms of the digestive tract, most frequently expressing the KIT protein detected by immunohistochemical staining for the CD117 antigen. Jejunal GISTs account for approximately 10 % of GISTs. Patients usually present with abdominal discomfort. Jejunal GISTs may cause symptoms secondary to obstruction or hemorrhage. Pressure necrosis and ulceration of the overlying mucosa may cause gastrointestinal bleeding, and patients who experience significant blood loss may suffer from malaise and fatigue. Literature has classified small-bowel GISTs on the basis of size, and various established guidelines have advised conservative management of small jejunal GISTs (<2 cm). We here report the clinical, macroscopic, and immunohistological features of a small jejunal GIST presenting with acute lower gastrointestinal hemorrhage in a 50-year-old postmenopausal woman necessitating an emergency laparotomy to control the bleed. The management of very small (<2 cm) small-bowel GISTs is controversial. While guidelines are primarily based on the risk of malignancy in GISTs, no guideline predicting the risk of complications in small-bowel GISTs exists. Hence, these tumors should be removed even if incidentally detected.
authors.affiliation: Department of General Surgery, St. John's Medical College Hospital, Bangalore, 560034 Karnataka India.
authors.forename: Sridar
authors.initials: S
authors.lastname: Govindaraj
authors.affiliation: Department of General Surgery, St. John's Medical College Hospital, Bangalore, 560034 Karnataka India.
authors.forename: Brendan Hermenigildo
authors.initials: BH
authors.lastname: Dias
authors.affiliation: Department of General Surgery, St. John's Medical College Hospital, Bangalore, 560034 Karnataka India.
authors.forename: S L
authors.initials: SL
authors.lastname: Gautham
keywords: GIST; Jejunal GIST; Lower GI bleed