title: The copper-catalyzed asymmetric construction of a dispiropyrrolidine skeleton via 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides.
abstract: A highly efficient asymmetric 1,3-dipolar cycloaddition of azomethine ylides to α-alkylidene succinimides catalyzed by a novel chiral N,O-ligand/Cu(OAc)2 system is reported, affording dispiropyrrolidine derivatives with spiro quaternary stereogenic centers in good to excellent yields (up to 90%), excellent levels of diastereoselectivities (>20 : 1 dr) and enantioselectivities (up to 97% ee).
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, People's Republic of China. xxyu@ecust.edu.cn weiping_deng@ecust.edu.cn.
authors.forename: Wu-Lin
authors.initials: WL
authors.lastname: Yang
authors.forename: Yang-Zi
authors.initials: YZ
authors.lastname: Liu
authors.forename: Shuai
authors.initials: S
authors.lastname: Luo
authors.forename: Xingxin
authors.initials: X
authors.lastname: Yu
authors.forename: John S
authors.initials: JS
authors.lastname: Fossey
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Deng
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D061565:Cycloaddition Reaction; D011759:Pyrrolidines / Q000737:chemistry*; D013388:Succinimides / Q000737:chemistry*; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D011759:Pyrrolidines; D013388:Succinimides; D013882:Thiosemicarbazones; C512188:azomethine; D003300:Copper