title: Serotonin syndrome after electroconvulsive therapy in a patient on trazodone, bupropion, and quetiapine: a case report.
abstract: BACKGROUND
  Serotonin syndrome is a potentially fatal complication that usually occurs in the combination use of several serotonergic agents. We presented a patient with major depressive disorder under the treatment of bupropion, trazodone, and quetiapine. Serotonin syndrome developed soon after she received the first session of electroconvulsive therapy (ECT).
  
  
  METHODS
  This study is a case report.
  
  
  RESULTS
  A 70-year-old female with major depressive disorder developed serotonin syndrome after the first session of ECT in combination with bupropion, trazodone, and quetiapine. Serotonin syndrome did not reappear in the subsequent ECT treatment while in the treatment with different therapeutic agents.
  
  
  CONCLUSIONS
  The superimposing effect of ECT in conjunction with serotonergic agents might contribute to the development of serotonin syndrome.
authors.affiliation: *Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital; and †Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Ying-Chih
authors.initials: YC
authors.lastname: Cheng
authors.forename: Chun-Mao
authors.initials: CM
authors.lastname: Liang
authors.forename: Hsing-Cheng
authors.initials: HC
authors.lastname: Liu
mesh_terms: D000368:Aged; D016642:Bupropion / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000009:adverse effects; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D004359:Drug Therapy, Combination / Q000009:adverse effects; D004565:Electroconvulsive Therapy / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006801:Humans; D000069348:Quetiapine Fumarate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D020230:Serotonin Syndrome / Q000139:chemically induced / Q000209:etiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D014196:Trazodone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D016642:Bupropion; D000069348:Quetiapine Fumarate; D017367:Selective Serotonin Reuptake Inhibitors; D014196:Trazodone