title: Sugar polymers exacerbate lung GVHD.
abstract: In this issue of Blood, Uryu et al demonstrate that recognition of a fungal cell wall component, α-mannan (Mn), an Mn (sugar) polymer, by the C-type lectin receptor Dectin-2 on host macrophages leads to a lung chemokine environment conducive to donor T helper (Th)17 accumulation resulting in severe pulmonary graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT). These findings shed new light on a long-standing gap in our understanding of the mechanistic link between infections, specifically fungal, and GVHD severity following allo-HSCT.
authors.affiliation: UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER.
authors.forename: Nathan
authors.initials: N
authors.lastname: Mathewson
authors.affiliation: UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER.
authors.forename: Pavan
authors.initials: P
authors.lastname: Reddy
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D020381:Interleukin-17 / Q000502:physiology*; D008171:Lung Diseases / Q000209:etiology*; D008351:Mannans / Q000009:adverse effects*; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D020381:Interleukin-17; D008351:Mannans