title: Progress of Circulating Tumor Cells in Cancer Management.
abstract: Circulating tumor cells are low-frequency cells that are shed into the peripheral bloodstream from a primary solid tumor and/or metastasis. Although these cells were recognized initially in 1869, it is only in the past 2 decades that they have been isolated for use as a surrogate biomarker to monitor response to therapy, evaluate prognosis, detect tumor mutations, assist in selecting personalized medicine, and enable earlier cancer diagnosis.
authors.affiliation: School of Medicine and Life Sciences, University of Jinan-Shandong, Academy of Medical Sciences, Jinan, China Academy of Medical Sciences, Shandong Cancer Hospital, Jinan, Shandong, China.
authors.forename: Chufeng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Medicine and Life Sciences, University of Jinan-Shandong, Academy of Medical Sciences, Jinan, China Academy of Medical Sciences, Shandong Cancer Hospital, Jinan, Shandong, China.
authors.forename: Lijie
authors.initials: L
authors.lastname: Wang
authors.affiliation: Academy of Medical Sciences, Shandong Cancer Hospital, Jinan, Shandong, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Academy of Medical Sciences, Shandong Cancer Hospital, Jinan, Shandong, China.
authors.forename: Yulan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Academy of Medical Sciences, Shandong Cancer Hospital, Jinan, Shandong, China.
authors.forename: Xiuju
authors.initials: X
authors.lastname: Liu
authors.affiliation: Academy of Medical Sciences, Shandong Cancer Hospital, Jinan, Shandong, China.
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Zhu
authors.affiliation: Academy of Medical Sciences, Shandong Cancer Hospital, Jinan, Shandong, China 2877975194@qq.com.
authors.forename: Qisen
authors.initials: Q
authors.lastname: Guo
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D009360:Neoplastic Cells, Circulating / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: circulating tumor cells; early diagnosis; enrichment; heterogeneity; personalized treatment; prognostic evaluation; response to therapy