title: OARSI Clinical Trials Recommendations: Hand imaging in clinical trials in osteoarthritis.
abstract: Tremendous advances have occurred in our understanding of the pathogenesis of hand osteoarthritis (OA) and these are beginning to be applied to trials targeted at modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply hand imaging assessments in disease modifying clinical trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for MRI); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations.
authors.affiliation: Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and Rheumatology Department, Royal North Shore Hospital, Sydney, NSW, Australia. Electronic address: David.Hunter@sydney.edu.au.
authors.forename: D J
authors.initials: DJ
authors.lastname: Hunter
authors.affiliation: NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, UK; Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, University of Oxford, UK.
authors.forename: N
authors.initials: N
authors.lastname: Arden
authors.affiliation: School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne 3004, Australia.
authors.forename: F
authors.initials: F
authors.lastname: Cicuttini
authors.affiliation: Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, United States; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, SP, Brazil.
authors.forename: M D
authors.initials: MD
authors.lastname: Crema
authors.affiliation: Department of Radiology & Radiological Sciences, Uniformed Services University of Health Sciences, Bethesda, MD, USA.
authors.forename: B
authors.initials: B
authors.lastname: Dardzinski
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, USA.
authors.forename: J
authors.initials: J
authors.lastname: Duryea
authors.affiliation: Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, United States.
authors.forename: A
authors.initials: A
authors.lastname: Guermazi
authors.affiliation: Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
authors.forename: I K
authors.initials: IK
authors.lastname: Haugen
authors.affiliation: Departments of Rheumatology and Clinical Epidemiology, Leiden University Medical Centre, 2300 RC, Leiden, Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Kloppenburg
authors.affiliation: Department of Rheumatology, Hôpital Saint-Antoine, AP-HP, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Maheu
authors.affiliation: Bioclinica, Newtown, PA, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Miller
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Martel-Pelletier
authors.affiliation: Department of Radiology, The American British Cowdray Medical Center IAP, Mexico.
authors.forename: R E
authors.initials: RE
authors.lastname: Ochoa-Albíztegui
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
authors.forename: J-P
authors.initials: JP
authors.lastname: Pelletier
authors.affiliation: Spire Sciences, Inc., Boca Raton, FL, USA.
authors.forename: C
authors.initials: C
authors.lastname: Peterfy
authors.affiliation: Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, United States; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Roemer
authors.affiliation: Stanford University, Departments of Radiology, Bioengineering, and Orthopedic Surgery, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Gold
mesh_terms: D002358:Cartilage, Articular / Q000473:pathology*; D002986:Clinical Trials as Topic / Q000592:standards*; D018450:Disease Progression; D050823:Hand Joints / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000592:standards*; D010003:Osteoarthritis / Q000175:diagnosis*; D017410:Practice Guidelines as Topic / Q000592:standards*
keywords: Guidelines; Hand osteoarthritis; Imaging