title: YidC/Alb3/Oxa1 Family of Insertases.
abstract: The YidC/Alb3/Oxa1 family functions in the insertion and folding of proteins in the bacterial cytoplasmic membrane, the chloroplast thylakoid membrane, and the mitochondrial inner membrane. All members share a conserved region composed of five transmembrane regions. These proteins mediate membrane insertion of an assorted group of proteins, ranging from respiratory subunits in the mitochondria and light-harvesting chlorophyll-binding proteins in chloroplasts to ATP synthase subunits in bacteria. This review discusses the YidC/Alb3/Oxa1 protein family as well as their function in membrane insertion and two new structures of the bacterial YidC, which suggest a mechanism for membrane insertion by this family of insertases.
authors.affiliation: From the Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210.
authors.forename: Seth W
authors.initials: SW
authors.lastname: Hennon
authors.affiliation: From the Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210.
authors.forename: Raunak
authors.initials: R
authors.lastname: Soman
authors.affiliation: From the Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhu
authors.affiliation: From the Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210 dalbey@chemistry.ohio-state.edu.
authors.forename: Ross E
authors.initials: RE
authors.lastname: Dalbey
mesh_terms: D008565:Membrane Proteins / Q000378:metabolism*; D013379:Substrate Specificity; D043324:beta-Fructofuranosidase / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D043324:beta-Fructofuranosidase
keywords: Alb3; Membrane protein insertion; Oxa1; YidC; YidC mechanism; membrane biogenesis; membrane enzyme; membrane insertion; membrane protein; membrane transport; molecular chaperone; protein translocation; structure-function