title: Analysis of the rate of maturogenesis of a traumatized Cvek's stage 3 anterior tooth treated with platelet-rich fibrin as a regenerative tool using three-dimensional cone-beam computed tomography: an original case report.
abstract: Regenerative endodontic procedures are biologically based procedures which deal with the regeneration of pulp-like tissue, more idealistically the pulp-dentin complex. The regeneration of this pulp-dentin complex in an infected necrotic tooth with an open apex is possible only when the canal is effectively disinfected. Though there are various procedures for treating open apex ranging from Ca(OH) 2 apexification, mineral trioxide aggregate apexification and surgical approach, regeneration of tissues has always taken superior hand over the repair of tissues. The mechanics behind the regenerative endodontic procedures is that despite the tooth being necrotic, some pulp tissue can survive apically which under favorable conditions proliferate to aid in the process of regeneration. In the past 2 decades, an increased understanding of the physiological roles of platelets in wound healing and after tissue injury has led to the idea of using platelets as therapeutic tools in the field regenerative endodontics. In the present case report with an open apex, high sterilization protocol is followed using triple antibiotic paste as intra-canal medicament, followed which platelet rich fibrin is used as the regenerative material of choice. Over an 18-month follow-up period, clinically patient is asymptomatic and radiographically there is complete regression of the periapical lesion and initiation of the root end closure.
authors.affiliation: Department of Conservative Dentistry and Endodontics, Panineeya Institute of Dental Sciences and Research Center, Dilsukhnagar, Telangana, India.
authors.forename: Raji Viola
authors.initials: RV
authors.lastname: Solomon
authors.forename: Umrana
authors.initials: U
authors.lastname: Faizuddin
authors.forename: Sushma Shravani
authors.initials: SS
authors.lastname: Guniganti
authors.forename: Shefali
authors.initials: S
authors.lastname: Waghray
mesh_terms: D000293:Adolescent; D017607:Aluminum Compounds / Q000627:therapeutic use; D056624:Apexification / Q000379:methods*; D001792:Blood Platelets; D017610:Calcium Compounds / Q000627:therapeutic use; D054893:Cone-Beam Computed Tomography; D004338:Drug Combinations; D005337:Fibrin / Q000627:therapeutic use; D006801:Humans; D007180:Incisor / Q000293:injuries* / Q000601:surgery*; D008297:Male; D010087:Oxides / Q000627:therapeutic use; D012038:Regeneration; D012388:Root Canal Irrigants / Q000627:therapeutic use; D012390:Root Canal Therapy / Q000379:methods; D017640:Silicates / Q000627:therapeutic use; D018677:Tooth Injuries / Q000000981:diagnostic imaging* / Q000601:surgery*
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012388:Root Canal Irrigants; D017640:Silicates; C086631:mineral trioxide aggregate; D005337:Fibrin