title: In Vivo IS6110 Profile Changes in a Mycobacterium tuberculosis Strain as Determined by Tracking over 14 Years.
abstract: Transposition and homologous recombination of IS6110 appear in Mycobacterium tuberculosis along in vivo sequential infections. These events were checked in different clones of a successful strain, M. tuberculosis Zaragoza, with the focus on a variant in which integration of a copy of IS6110 in the origin of replication (oriC) region occurred.
authors.affiliation: Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain Hospital Universitario Miguel Servet, Zaragoza, Spain CIBER de Enfermedades Respiratorias, Zaragoza, Spain.
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Millán-Lou
authors.affiliation: Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain CIBER de Enfermedades Respiratorias, Zaragoza, Spain Universidad de Zaragoza, Zaragoza, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Otal
authors.affiliation: Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain Hospital Universitario Miguel Servet, Zaragoza, Spain CIBER de Enfermedades Respiratorias, Zaragoza, Spain.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Monforte
authors.affiliation: Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain CIBER de Enfermedades Respiratorias, Zaragoza, Spain Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
authors.forename: María Asunción
authors.initials: MA
authors.lastname: Vitoria
authors.affiliation: Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain Hospital Universitario Miguel Servet, Zaragoza, Spain CIBER de Enfermedades Respiratorias, Zaragoza, Spain.
authors.forename: María José
authors.initials: MJ
authors.lastname: Revillo
authors.affiliation: Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain Hospital Universitario Miguel Servet, Zaragoza, Spain CIBER de Enfermedades Respiratorias, Zaragoza, Spain Universidad de Zaragoza, Zaragoza, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Martín
authors.affiliation: Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain Hospital Universitario Miguel Servet, Zaragoza, Spain CIBER de Enfermedades Respiratorias, Zaragoza, Spain ssamper.iacs@aragon.es.
authors.forename: Sofía
authors.initials: S
authors.lastname: Samper
mesh_terms: D016000:Cluster Analysis; D016172:DNA Fingerprinting; D004251:DNA Transposable Elements; D019143:Evolution, Molecular; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D018598:Minisatellite Repeats; D058889:Molecular Typing; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic; D018741:Replication Origin; D014376:Tuberculosis / Q000382:microbiology*
chemical_list: D004251:DNA Transposable Elements