title: Current exposure of Italian women of reproductive age to PFOS and PFOA: A human biomonitoring study.
abstract: Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) concentrations were determined in serum samples collected in 2011-2012 from 549 nulliparous Italian women of reproductive age who resided in six different Italian Regions. Assessment of exposure to perfluorinated compounds was part of a large human biomonitoring study (Project Life Plus "Womenbiopop") that aimed at examining the exposure of women of reproductive age to priority organic pollutants. The median concentrations of PFOS and PFOA were 2.43, and 1.55 ng g(-1), respectively. Significant differences in the concentrations of both compounds were observed among the six Regions. Women from central Italy had the highest levels of both compounds, followed by women from northern Italy, and southern Italy. No differences in the PFOS concentrations were found between women from urban/industrial areas and women from rural areas, whereas the levels of PFOA were significantly higher in women residing in urban/industrial areas than in women residing in rural areas. Taken together, the observed concentrations confirm that the overall exposure of the Italian population is among the lowest observed in industrialized countries. A downward temporal trend in exposure was observed for both compounds when comparing the results from the present study with those assessed in a study conducted in 2008.
authors.affiliation: Istituto Superiore di Sanità, Dipartimento Ambiente e connessa Prevenzione Primaria, Roma, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: De Felip
authors.affiliation: Istituto Superiore di Sanità, Dipartimento Ambiente e connessa Prevenzione Primaria, Roma, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Abballe
authors.affiliation: Ospedale Ostetrico Ginecologico Sant'Anna, Città della Salute e della Scienza, Torino, Italy.
authors.forename: Fulvia Lucia
authors.initials: FL
authors.lastname: Albano
authors.affiliation: ASL Taranto, Dipartimento Prevenzione, Taranto, Italy.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Battista
authors.affiliation: Azienda Provinciale per i Servizi Sanitari della Provincia Autonoma di Trento, Unità Operativa Igiene e Sanità Pubblica, Trento, Italy.
authors.forename: Valter
authors.initials: V
authors.lastname: Carraro
authors.affiliation: ASL Taranto, Dipartimento Prevenzione, Taranto, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Conversano
authors.affiliation: Azienda Provinciale per i Servizi Sanitari della Provincia Autonoma di Trento, Unità Operativa Igiene e Sanità Pubblica, Trento, Italy.
authors.forename: Silva
authors.initials: S
authors.lastname: Franchini
authors.affiliation: Azienda di rilievo Nazionale e di Alta Specializzazione, Ospedale Civico di Palermo, U.O.C. di Ginecologia e Ostetricia, Palermo, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Giambanco
authors.affiliation: Istituto Superiore di Sanità, Dipartimento Ambiente e connessa Prevenzione Primaria, Roma, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Iacovella
authors.affiliation: Istituto Superiore di Sanità, Dipartimento Ambiente e connessa Prevenzione Primaria, Roma, Italy. Electronic address: annamaria.ingelido@iss.it.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Ingelido
authors.affiliation: Azienda di rilievo Nazionale e di Alta Specializzazione, Ospedale Civico di Palermo, U.O.C. di Ginecologia e Ostetricia, Palermo, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Maiorana
authors.affiliation: Azienda Sanitaria Locale di Latina, P.O. Nord "S. Maria Goretti", U.O.C. Ostetricia e Ginecologia, Latina, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Maneschi
authors.affiliation: Istituto Superiore di Sanità, Dipartimento Ambiente e connessa Prevenzione Primaria, Roma, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Marra
authors.affiliation: Azienda di rilievo Nazionale e di Alta Specializzazione, Ospedale Civico di Palermo, U.O.C. di Ginecologia e Ostetricia, Palermo, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Mercurio
authors.affiliation: Azienda Sanitaria Locale di Latina, P.O. Nord "S. Maria Goretti", U.O.C. Ostetricia e Ginecologia, Latina, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Nale
authors.affiliation: ASL 5 Pinerolo (To), Italy.
authors.forename: Bianca
authors.initials: B
authors.lastname: Nucci
authors.affiliation: ASL Roma D, Roma, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Panella
authors.affiliation: ASL Roma D, Roma, Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: Pirola
authors.affiliation: Dipartimento di Scienze Ginecologiche e Ostetriche eScienze Urologiche - Università di Roma, "Sapienza" Roma, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Porpora
authors.affiliation: ASL 5 Susa (To), Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Procopio
authors.affiliation: ASL 5 Susa (To), Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Suma
authors.affiliation: Istituto Superiore di Sanità, Dipartimento Ambiente e connessa Prevenzione Primaria, Roma, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Valentini
authors.affiliation: ex ASL 4 Terni (now ASL Umbria 2), U.O.C. Igiene e Sanità Pubblica, Terni, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Valsenti
authors.affiliation: ASL 5 Pinerolo (To), Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Vecchiè
mesh_terms: D000328:Adult; D017738:Alkanesulfonic Acids / Q000097:blood*; D002210:Caprylates / Q000097:blood*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D007558:Italy; D012098:Reproduction; D062211:Spatio-Temporal Analysis; D055815:Young Adult
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D004785:Environmental Pollutants; D005466:Fluorocarbons; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid
keywords: Biomonitoring; Italy; PFOA; PFOS; Women