title: Variants in the Mannose-binding Lectin Gene MBL2 do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort.
abstract: BACKGROUND
  Sepsis is an increasingly common condition, which continues to be associated with unacceptably high mortality. A large number of association studies have investigated susceptibility to, or mortality from, sepsis for variants in the functionally important immune-related gene MBL2. These studies have largely been underpowered and contradictory.
  
  
  METHODS
  We genotyped and analyzed 4 important MBL2 single nucleotide polymorphisms (SNPs; rs5030737, rs1800450, rs1800451, and rs7096206) in 1839 European community-acquired pneumonia (CAP) and peritonitis sepsis cases, and 477 controls from the United Kingdom. We analyzed the following predefined subgroups and outcomes: 28-day and 6 month mortality from sepsis due to CAP or peritonitis combined, 28-day mortality from CAP sepsis, peritonitis sepsis, pneumococcal sepsis or sepsis in younger patients, and susceptibility to CAP sepsis or pneumococcal sepsis in the United Kingdom.
  
  
  RESULTS
  There were no significant associations (all P-values were greater than .05 after correction for multiple testing) between MBL2 genotypes and any of our predefined analyses.
  
  
  CONCLUSIONS
  In this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified.
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford.
authors.forename: Tara C
authors.initials: TC
authors.lastname: Mills
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford.
authors.forename: Stephen
authors.initials: S
authors.lastname: Chapman
authors.affiliation: John Radcliffe Hospital, Oxford.
authors.forename: Paula
authors.initials: P
authors.lastname: Hutton
authors.affiliation: Section of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London.
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Gordon
authors.affiliation: School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom.
authors.forename: Julian
authors.initials: J
authors.lastname: Bion
authors.affiliation: Hospital Cochin, Paris, France.
authors.forename: Jean-Daniel
authors.initials: JD
authors.lastname: Chiche
authors.affiliation: Section of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London.
authors.forename: Paul A H
authors.initials: PA
authors.lastname: Holloway
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Bern University Hospital and University of Bern, Switzerland.
authors.forename: Frank
authors.initials: F
authors.lastname: Stüber
authors.affiliation: John Radcliffe Hospital, Oxford.
authors.forename: Chris S
authors.initials: CS
authors.lastname: Garrard
authors.affiliation: Barts and The London School of Medicine Queen Mary University of London, United Kingdom.
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Hinds
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford.
authors.forename: Adrian V S
authors.initials: AV
authors.lastname: Hill
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford.
authors.forename: Anna
authors.initials: A
authors.lastname: Rautanen
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018805:Sepsis / Q000453:epidemiology* / Q000235:genetics*
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin
keywords: MBL; association study; genetics; mannose-binding lectin; sepsis