title: Severe bronchiectasis in a patient with common variable immunodeficiency.
abstract: BACKGROUND
  Bronchiectasis are common in Common Variable Immunodeficiency. These patients are prone to infection, leading to progressive lung destruction and accelerated FEV1 decline.
  
  
  METHODS
  40 year-old man, with recurrent respiratory infections, autoimmunity and diarrhea since age 7. At 17 CVID was diagnosed and IVIgG was started. During the following years, respiratory symptoms progressively worsened and bronchiectasis was found on thoracic computed tomography. Bronchoscopy revealed Pseudomonas aeruginosa in bronchoalveolar lavage and bronchial secretions cultures. Eradication therapy led to clinical improvement.
  
  
  CONCLUSIONS
  This case report stresses the importance of regular microbiological screening and appropriate antibiotherapy. Early/aggressive treatment may significantly impact on patients' evolution.
authors.affiliation: Immunoallergology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte CHLN, Lisboa, Portugal. Av. Professor Egas Moniz 1649-035 Lisbon, Portugal. E-mail: viegas.lp@gmail.com Phone: +351 918 65 11 06.
authors.forename: L Paulos
authors.initials: LP
authors.lastname: Viegas
authors.affiliation: Immunoallergology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte CHLN, Lisboa, Portugal. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: S P
authors.initials: SP
authors.lastname: Silva
authors.affiliation: Immunoallergology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte CHLN, Lisboa, Portugal. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal. Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: S L
authors.initials: SL
authors.lastname: Silva
authors.affiliation: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Campos Melo
authors.affiliation: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: A
authors.initials: A
authors.lastname: Serra-Caetano
authors.affiliation: Immunoallergology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte CHLN, Lisboa, Portugal. Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Branco-Ferreira
authors.affiliation: Serviço de Pneumologia, Hospital Santa Maria, CHLN, Lisboa, Portugal.
authors.forename: P
authors.initials: P
authors.lastname: Azevedo
authors.affiliation: Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal. Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: M C
authors.initials: MC
authors.lastname: Pereira-Santos
authors.affiliation: Immunoallergology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte CHLN, Lisboa, Portugal. Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
authors.forename: M
authors.initials: M
authors.lastname: Pereira-Barbosa
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001987:Bronchiectasis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D001999:Bronchoscopy; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D016756:Immunoglobulins, Intravenous
keywords: CVID; Pseudomonas; bronchiectasis