title: Features of Patients With Crohn's Disease and Hidradenitis Suppurativa.
abstract: OBJECTIVE
  There have been reports of an association between Crohn's disease and hidradenitis suppurativa, a chronic, relapsing, inflammatory condition of the skin. We investigated features of hidradenitis suppurativa in patients with Crohn's disease by analyzing clinical data and performing a literature review.
  
  
  METHODS
  We performed a retrospective study by using information from the Mount Sinai Medical Center database from 2003 through 2013; International Classification of Diseases, 9th Revision codes were used to identify patients who had both Crohn's disease and hidradenitis suppurativa. We identified a total of 18 patients with inflammatory bowel disease (15 with Crohn's disease, 3 with ulcerative colitis) and hidradenitis suppurativa. We also performed a systematic search for publications listed in PubMed through December 2013.
  
  
  RESULTS
  We identified 15 patients with Crohn's disease and hidradenitis suppurativa who met the inclusion criteria (11 women, 4 men). Nine patients were black, 5 were white, and 1 was Asian. Regions most affected by hidradenitis suppurativa included the axilla (53%), inguinal region (47%), and perianal region (73%). Seven patients had colonic Crohn's disease, and 8 had ileocolonic Crohn's disease; 10 patients had perianal disease. Fourteen patients received medical treatment for hidradenitis suppurativa and for Crohn's disease. Twelve patients were treated with tumor necrosis factor inhibitors for Crohn's disease (11 received infliximab and 4 received adalimumab). Nine patients required dose escalation; 11 responded to tumor necrosis factor inhibitors, and 8 required surgery. Four patients were treated with tumor necrosis factor inhibitors for hidradenitis suppurativa (all with infliximab). Three required a dose escalation; 4 responded to tumor necrosis factor inhibitors, and 3 required surgery.
  
  
  CONCLUSIONS
  Crohn's disease and hidradenitis suppurativa are severe inflammatory conditions that can develop in the same patient. They frequently require increased medical and surgical therapy.
authors.affiliation: Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Natasha
authors.initials: N
authors.lastname: Kamal
authors.affiliation: Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Cohen
authors.affiliation: Department of Dermatology, Hopital Huriez, CHU Lille, Lille, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Buche
authors.affiliation: Department of Dermatology, Hopital Huriez, CHU Lille, Lille, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Delaporte
authors.affiliation: Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: jean-frederic.colombel@mssm.edu.
authors.forename: Jean-Frederic
authors.initials: JF
authors.lastname: Colombel
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003424:Crohn Disease / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D005260:Female; D017497:Hidradenitis Suppurativa / Q000150:complications* / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents
keywords: Anti-TNF; Autoimmune; Inflammation; Inflammatory Bowel Disease