title: Aldosterone Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic Kidney Disease.
abstract: BACKGROUND
  It has been shown that gene polymorphisms influence the development and progression of chronic kidney disease (CKD). Many studies have indicated that aldosterone synthase CYP11B2 gene polymorphism (-344C>T) influences the aldosterone level, urinary aldosterone excretion, blood pressure, and left ventricular size and mass. We aimed to investigate whether there is an effect of CYP11B2 -344 C>T polymorphism on the development of CKD in a Turkish population.
  
  
  METHODS
  A total of 240 patients with stage 5 CKD and 240 age- and sex-matched healthy individuals were included in the study. Genotyping of CYP11B2 gene -344 T>C promoter polymorphism was carried out using polymerase chain reaction and restriction fragment length polymorphism methods.
  
  
  RESULTS
  No significant differences were found in the genotype distribution of CYP11B2 -344 C>T polymorphism between the patients and controls; however, -344 C>T polymorphism was significantly more frequent among the CKD patients with diabetes mellitus as compared to those with it (P = .02). Diabetic CKD patients with TC genotype had a 2-fold increased risk for development of the disease than the CKD patients without diabetes mellitus (odds ratio, 2.21; 95% confidence interval, 1.04 to 4.67).
  
  
  CONCLUSIONS
  Our study suggests that the CYP11B2 gene -344 C>T polymorphism may have an effect on the development of CKD in diabetic patients.
authors.affiliation: Department of Research Centre, Cumhuriyet University, School of Medicine, Sivas, Turkey. meralylmz@gmail.com.
authors.forename: Meral
authors.initials: M
authors.lastname: Yilmaz
authors.forename: Ismail
authors.initials: I
authors.lastname: Sari
authors.forename: Binnur
authors.initials: B
authors.lastname: Bagci
authors.forename: Erkan
authors.initials: E
authors.lastname: Gumus
authors.forename: Ozturk
authors.initials: O
authors.lastname: Ozdemir
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic; D051436:Renal Insufficiency, Chronic / Q000235:genetics*; D014421:Turkey
chemical_list: D019405:Cytochrome P-450 CYP11B2