title: Hyper-radiosensitivity and induced radioresistance and bystander effects in rodent and human cells as a function of radiation quality.
abstract: In the past two decades, a body of experimental evidences in vitro has shown the presence of a plethora of phenomena occurring after low-dose irradiation [including hypersensitivity and induced radioresistance (IRR), adaptive response, bystander effect (BE) and genomic instability], which might imply a non-linear behaviour of cancer risk curves in the low-dose region and question the validity of the linear no-threshold model for cancer risk assessment in such a dose region. In this framework, a systematic investigation have been undertaken on non-linear effects at low doses as a function of different radiation quality and cellular radiosensitivity and in terms of different biological end points. The present article reports the recent results on hyper-radiosensitivity and IRR and BE phenomena, in terms of clonogenic survival in V79 Chinese hamster cells and T98G human glioblastoma cells irradiated with protons and carbon ions with different energy, as a function of dose (and fluence).
authors.affiliation: Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Viale dell'Università 2, Legnaro, Padova 35020, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Cherubini
authors.affiliation: Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Viale dell'Università 2, Legnaro, Padova 35020, Italy viviana.de.nadal@lnl.infn.it.
authors.forename: V
authors.initials: V
authors.lastname: De Nadal
authors.affiliation: Laboratori Nazionali di Legnaro, Istituto Nazionale di Fisica Nucleare, Viale dell'Università 2, Legnaro, Padova 35020, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Gerardi
mesh_terms: D000818:Animals; D024201:Bystander Effect / Q000528:radiation effects*; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage / Q000528:radiation effects*; D005347:Fibroblasts / Q000166:cytology* / Q000528:radiation effects; D042822:Genomic Instability; D005909:Glioblastoma / Q000473:pathology* / Q000532:radiotherapy; D063193:Heavy Ion Radiotherapy; D006801:Humans; D008168:Lung / Q000166:cytology* / Q000528:radiation effects; D011522:Protons; D011829:Radiation Dosage; D011836:Radiation Tolerance
chemical_list: D011522:Protons