title: Beneficial Effects of Polyphenol-Rich Chokeberry Juice Consumption on Blood Pressure Level and Lipid Status in Hypertensive Subjects.
abstract: Epidemiological studies have shown a positive association between intake of foods rich in antioxidants and lower incidence of cardiovascular disease development. Polyphenols are considered the most abundant and important dietary antioxidants. The aim of this study was to evaluate effects of polyphenol-rich chokeberry juice consumption on 24-h ambulatory monitored blood pressure (BP) level in subjects with no pharmacologically treated high normal BP or grade I hypertension. Twenty-three subjects (12 men and 11 women) aged 33-67 were enrolled and instructed to consume 200 mL of juice daily for 4 weeks. Participants were divided in two groups, based on prevalence of sympathetic or parasympathetic activity. Measurements of biochemical parameters and heart rate variability analysis were also applied. At the end of the intervention period, average 24-h and awake systolic and diastolic BP were significantly decreased (P<.05). This was more pronounced in the group with prevalence of sympathetic activity. Significant reduction in triglyceride level (P<.05) and a reducing effect on total and low-density lipoprotein cholesterol were also found. Obtained results indicate a positive impact of regular chokeberry juice consumption on BP and lipid status in pharmacologically untreated hypertensive subjects.
authors.affiliation: 1 Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade , Belgrade, Serbia .
authors.forename: Nevena
authors.initials: N
authors.lastname: Kardum
authors.affiliation: 2 Department of Cardiology, University Clinical Center Bezanijska Kosa, University of Belgrade , Belgrade, Serbia .
authors.forename: Branislav
authors.initials: B
authors.lastname: Milovanović
authors.affiliation: 3 Institute for Medicinal Plants Research , Belgrade, Serbia .
authors.forename: Katarina
authors.initials: K
authors.lastname: Šavikin
authors.affiliation: 3 Institute for Medicinal Plants Research , Belgrade, Serbia .
authors.forename: Gordana
authors.initials: G
authors.lastname: Zdunić
authors.affiliation: 2 Department of Cardiology, University Clinical Center Bezanijska Kosa, University of Belgrade , Belgrade, Serbia .
authors.forename: Slavica
authors.initials: S
authors.lastname: Mutavdžin
authors.affiliation: 2 Department of Cardiology, University Clinical Center Bezanijska Kosa, University of Belgrade , Belgrade, Serbia .
authors.forename: Tatjana
authors.initials: T
authors.lastname: Gligorijević
authors.affiliation: 4 Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade , Belgrade, Serbia .
authors.forename: Slavica
authors.initials: S
authors.lastname: Spasić
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005638:Fruit / Q000737:chemistry; D000067030:Fruit and Vegetable Juices; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D046936:Photinia / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D059808:Polyphenols / Q000494:pharmacology / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D008055:Lipids; D010936:Plant Extracts; D059808:Polyphenols; D014280:Triglycerides; D002784:Cholesterol
keywords: blood pressure; cardiovascular health; chokeberry; polyphenols; triglycerides