title: Association between interleukin-10-3575T>A (rs1800890) polymorphism and cancer risk.
abstract: BACKGROUND
  Previous studies investigated the associations of interleukin-10 (IL-10) polymorphisms with different types of cancer, indicating an influence on cancer risk. IL-10-3575T>A (rs1800890) has been studied concerning a potential implication in terms of some cancer site risks, but the results from single studies are contradictory.
  
  
  METHODS
  Eligible articles were identified by a search of the PubMed, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) databases until November 30, 2014. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the cancer risk by cancer sites, ethnicity, and other study features.
  
  
  RESULTS
  We identified 15 published studies to research the link of the IL-10-3575T>A polymorphism with cancer risk. Our meta-analysis indicated that the IL-10-3575T>A polymorphism has a significant association with decreased melanoma risk in the heterozygote model (OR=0.67, 95% CI=0.49-0.92, p=0.02) and dominant model (OR=0.70, 95% CI=0.52-0.95, p=0.01), but increased diffuse large B-cell lymphoma (DLBCL) risk in all the different genetic models.
  
  
  CONCLUSIONS
  Our analysis suggests that the IL-10-3575T>A mutation may associate with melanoma and DLBCL and exert a differential effect in different cancer sites. However, other factors may influence the association, and large-scale multicenter with adequate methodological quality studies are needed to confirm the impact on cancer susceptibility.
authors.affiliation: 1 Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Dai
authors.affiliation: 1 Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1 Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Xing-Mei
authors.initials: XM
authors.lastname: Cao
authors.affiliation: 1 Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 2 Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: 2 Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Xing-Han
authors.initials: XH
authors.lastname: Liu
authors.affiliation: 3 Department of Pediatrics, Jiuquan City People's Hospital , Jiuquan, China .
authors.forename: Chang-Ji
authors.initials: CJ
authors.lastname: Li
authors.affiliation: 2 Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Dai
authors.affiliation: 1 Department of Hematology, The Second Affiliated Hospital of Xi'an Jiaotong University , Xi'an, China .
authors.forename: Wang-Gang
authors.initials: WG
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D008545:Melanoma / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D016753:Interleukin-10