title: Perivascular adipose adiponectin correlates with symptom status of patients undergoing carotid endarterectomy.
abstract: OBJECTIVE
  Recent symptoms stand as a major determinant of stroke risk in patients with carotid stenosis, likely reflective of atherosclerotic plaque destabilization. In view of emerging links between vascular and adipose biology, we hypothesized that human perivascular adipose characteristics associate with carotid disease symptom status.
  
  
  METHODS
  Clinical history, carotid plaques, blood, and subcutaneous and perivascular adipose tissues were prospectively collected from patients undergoing carotid endarterectomy. Nine adipose-associated biological mediators were assayed and compared in patients with symptomatic (n=15) versus asymptomatic (n=19) disease. Bonferroni correction was performed for multiple testing (α/9=0.006).
  
  
  RESULTS
  Symptomatic patients had 1.9-fold higher perivascular adiponectin levels (P=0.005). Other circulating, subcutaneous, and perivascular biomarkers, as well as microscopic plaque characteristics, did not differ between symptomatic and asymptomatic patients.
  
  
  CONCLUSIONS
  Symptomatic and asymptomatic carotid endarterectomy patients display a tissue-specific difference in perivascular adipose adiponectin. This difference, which was not seen in plasma or subcutaneous compartments, supports a potential local paracrine relationship with vascular disease processes that may be related to stroke mechanisms.
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
authors.forename: Gaurav
authors.initials: G
authors.lastname: Sharma
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
authors.forename: Ming
authors.initials: M
authors.lastname: Tao
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
authors.forename: Kui
authors.initials: K
authors.lastname: Ding
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
authors.forename: David
authors.initials: D
authors.lastname: Yu
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
authors.forename: William
authors.initials: W
authors.lastname: King
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
authors.forename: Galina
authors.initials: G
authors.lastname: Deyneko
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
authors.forename: Xiaosong
authors.initials: X
authors.lastname: Wang
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
authors.forename: Alban
authors.initials: A
authors.lastname: Longchamp
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
authors.forename: Frederick J
authors.initials: FJ
authors.lastname: Schoen
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.).
authors.forename: C Keith
authors.initials: CK
authors.lastname: Ozaki
authors.affiliation: From the Departments of Surgery (G.S., M.T., K.D., W.K., A.L., C.K.O., M.E.S.) and Pathology (F.J.S.), Brigham and Women's Hospital/Harvard Medical School, Boston, MA; University of Washington School of Medicine, Seattle, WA (D.Y.); and Novartis Institutes for BioMedical Research, Cambridge, MA (G.D., X.W.). msemel1@partners.org.
authors.forename: Marcus E
authors.initials: ME
authors.lastname: Semel
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D016893:Carotid Stenosis / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019899:Paracrine Communication; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000378:metabolism / Q000473:pathology
chemical_list: D052242:Adiponectin; D015415:Biomarkers
keywords: adipokines; adiponectin; atherosclerosis; carotid stenosis; endarterectomy, carotid