title: [Changes in functional activity of neutrophils in peripheral blood of patients with renal cell cancer in the course of the disease].
abstract: OBJECTIVE
  Research purpose was to study phagocytic activity and a oxygen depended metabolism of blood neutrophils (NF) at patients with a renal cell carcinoma in dynamics - before operation and after surgical treatment. METHODs; Patients with a locally invasive renal cell carcinoma (T3N0M0) were put under observation before surgical treatment (n =84) and in 10 days after a radical nephrectomy (n =54) at the age of 45-55 years. The 56 conditionally healthy donors combine into the control group. Indicators of functional activity, the spontaneous and induced lyuminol- and lyutsigenin-dependent chemiluminescence (CHL) NF of pedipheral blood was studied.
  
  
  RESULTS
  During the period before operation time of an exit to a maximum of spontaneous and stimulated lyuminol-dependent HL is slowed down (p <0.004 and p <0.006 respectively); indicators of the area of lyutsigenin-dependent HL NF of blood concerning indicators of control group are increased (p <0.01 for spontaneous, p <0.004 for the reaction induced by lyutsigenin). In 10 days after surgical treatment the quantity of active ingestion rate decreased (p <0.017 in the test with S. epidermidis, p <0.036 for test with latex); time of an exit to a maximum of spontaneous and stimulated lyuminol-dependent remained increased (p <0.006 and p <0.008 respectively) in comparison with indicators of healthy donors. The amount of an index of activation of lyuminol-dependent as in comparison with control (p <0.037), and relative to the period before operation increased (p <0.048). The area of spontaneous lyutsigenin-dependent HL NF of blood relative to indicators of control group was still increased (p <0.011), decrease in this parameter in comparison with amount of group before operation was however registered (p <0.004).
  
  
  CONCLUSIONS
  At patients with renal cell carcinoma in 10 days after surgical treatment of NF of blood were characterized by the strengthened production of high-energy oxidizers and the reduced phagocytic activity that testifies to a functional and metabolic imbalance.
authors.forename: L M
authors.initials: LM
authors.lastname: Kurtasova
authors.forename: E A
authors.initials: EA
authors.lastname: Shkapova
authors.forename: R A
authors.initials: RA
authors.lastname: Zukov
mesh_terms: D002292:Carcinoma, Renal Cell / Q000097:blood / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009392:Nephrectomy / Q000379:methods*; D009504:Neutrophils / Q000378:metabolism*; D019990:Perioperative Care / Q000379:methods; D010587:Phagocytosis