title: Numerical Modeling of Intraventricular Flow during Diastole after Implantation of BMHV.
abstract: This work presents a numerical simulation of intraventricular flow after the implantation of a bileaflet mechanical heart valve at the mitral position. The left ventricle was simplified conceptually as a truncated prolate spheroid and its motion was prescribed based on that of a healthy subject. The rigid leaflet rotation was driven by the transmitral flow and hence the leaflet dynamics were solved using fluid-structure interaction approach. The simulation results showed that the bileaflet mechanical heart valve at the mitral position behaved similarly to that at the aortic position. Sudden area expansion near the aortic root initiated a clockwise anterior vortex, and the continuous injection of flow through the orifice resulted in further growth of the anterior vortex during diastole, which dominated the intraventricular flow. This flow feature is beneficial to preserving the flow momentum and redirecting the blood flow towards the aortic valve. To the best of our knowledge, this is the first attempt to numerically model intraventricular flow with the mechanical heart valve incorporated at the mitral position using a fluid-structure interaction approach. This study facilitates future patient-specific studies.
authors.affiliation: National Heart Research Institute of Singapore, National Heart Centre Singapore, Singapore, Singapore.
authors.forename: Boyang
authors.initials: B
authors.lastname: Su
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
authors.forename: Foad
authors.initials: F
authors.lastname: Kabinejadian
authors.affiliation: Department of Surgery, National University of Singapore, Singapore, Singapore.
authors.forename: Hui Qun
authors.initials: HQ
authors.lastname: Phang
authors.affiliation: Institute of High Performance Computing, ASTAR, Singapore, Singapore.
authors.forename: Gideon Praveen
authors.initials: GP
authors.lastname: Kumar
authors.affiliation: Institute of High Performance Computing, ASTAR, Singapore, Singapore.
authors.forename: Fangsen
authors.initials: F
authors.lastname: Cui
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
authors.forename: Sangho
authors.initials: S
authors.lastname: Kim
authors.affiliation: National Heart Research Institute of Singapore, National Heart Centre Singapore, Singapore, Singapore.
authors.forename: Ru San
authors.initials: RS
authors.lastname: Tan
authors.affiliation: Department of Surgery, National University of Singapore, Singapore, Singapore.
authors.forename: Jimmy Kim Fatt
authors.initials: JK
authors.lastname: Hon
authors.affiliation: Duke-NUS Graduate Medical School, Singapore, Singapore.
authors.forename: John Carson
authors.initials: JC
authors.lastname: Allen
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
authors.forename: Hwa Liang
authors.initials: HL
authors.lastname: Leo
authors.affiliation: National Heart Research Institute of Singapore, National Heart Centre Singapore, Singapore, Singapore; Duke-NUS Graduate Medical School, Singapore, Singapore.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhong
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity; D003198:Computer Simulation; D003971:Diastole; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006352:Heart Ventricles; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D016276:Ventricular Function; D017725:Ventricular Pressure