title: Bioresorbable polyelectrolytes for smuggling drugs into cells.
abstract: There is ample evidence that biodegradable polyelectrolyte nanocapsules are multifunctional vehicles which can smuggle drugs into cells, and release them upon endogenous activation. A large number of endogenous stimuli have already been tested in vitro, and in vivo research is escalating. Thus, the interest in the design of intelligent polyelectrolyte multilayer (PEM) drug delivery systems is clear. The need of the hour is a systematic translation of PEM-based drug delivery systems from the lab to clinical studies. Reviews on multifarious stimuli that can trigger the release of drugs from such systems already exist. This review summarizes the available literature, with emphasis on the recent progress in PEM-based drug delivery systems that are receptive in the presence of endogenous stimuli, including enzymes, glucose, glutathione, pH, and temperature, and addresses different active and passive drug targeting strategies. Insights into the current knowledge on the diversified endogenous approaches and methodological challenges may bring inspiration to resolve issues that currently bottleneck the successful implementation of polyelectrolytes into the catalog of third-generation drug delivery systems.
authors.affiliation: a SRM Research Institute, SRM University , Kattankulathur, 603203 , Chennai , Tamil Nadu , India.
authors.forename: Sripriya
authors.initials: S
authors.lastname: Jaganathan
mesh_terms: D000818:Animals; D006801:Humans; D053769:Nanocapsules / Q000737:chemistry*; D000071228:Polyelectrolytes / Q000737:chemistry*
chemical_list: D053769:Nanocapsules; D000071228:Polyelectrolytes
keywords: active and passive targeting; bioencapsulation; drug delivery; endogenous stimuli; layer-by-layer method