title: Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8.
abstract: Terfestatins B (1) and C (2), new p-terphenyls bearing a novel unsaturated hexuronic acid (4-deoxy-α-L-threo-hex-4-enopyranuronate), a unique β-D-glycosyl ester of 5-isoprenylindole-3-carboxylate (3) and the same rare sugar, and two new hygromycin precursors, were characterized as metabolites of the coal mine fire isolate Streptomyces sp. RM-5-8. EtOH damage neuroprotection assays using rat hippocampal-derived primary cell cultures with 1, 2, 3 and echoside B (a terfestatin C-3'-β-D-glucuronide from Streptomyces sp. RM-5-8) revealed 1 as potently neuroprotective, highlighting a new potential application of the terfestatin scaffold.
authors.forename: Xiachang
authors.initials: X
authors.lastname: Wang
authors.forename: Anna R
authors.initials: AR
authors.lastname: Reynolds
authors.forename: Sherif I
authors.initials: SI
authors.lastname: Elshahawi
authors.forename: Khaled A
authors.initials: KA
authors.lastname: Shaaban
authors.forename: Larissa V
authors.initials: LV
authors.lastname: Ponomareva
authors.forename: Meredith A
authors.initials: MA
authors.lastname: Saunders
authors.forename: Ibrahim S
authors.initials: IS
authors.lastname: Elgumati
authors.forename: Yinan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: ∥Center for Applied Energy Research, University of Kentucky, Lexington, Kentucky 40511, United States.
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Copley
authors.affiliation: ∥Center for Applied Energy Research, University of Kentucky, Lexington, Kentucky 40511, United States.
authors.forename: James C
authors.initials: JC
authors.lastname: Hower
authors.forename: Manjula
authors.initials: M
authors.lastname: Sunkara
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Morris
authors.affiliation: #School of Pharmacy, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, United States.
authors.forename: Madan K
authors.initials: MK
authors.lastname: Kharel
authors.forename: Steven G
authors.initials: SG
authors.lastname: Van Lanen
authors.forename: Mark A
authors.initials: MA
authors.lastname: Prendergast
authors.forename: Jon S
authors.initials: JS
authors.lastname: Thorson
mesh_terms: D000818:Animals; D005960:Glucosides / Q000737:chemistry*; D020719:Glucuronides / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry*; D015394:Molecular Structure; D051381:Rats; D013302:Streptomyces / Q000737:chemistry*; D013730:Terphenyl Compounds / Q000737:chemistry*
chemical_list: D005960:Glucosides; D020719:Glucuronides; D006027:Glycosides; D006603:Hexuronic Acids; D013730:Terphenyl Compounds; C506193:terfestatin A; C000602112:terfestatin B; C000602039:terfestatin C