title: Iron-catalyzed C(sp(2))-H and C(sp(3))-H methylations of amides and anilides.
abstract: The so-called magic methyl effect significantly boosts the bioactivities and physical properties of pharmacologically active drugs. Direct introduction of the methyl group by CH activation was accomplished with a versatile iron catalyst, which enabled the CH methylation of (hetero)benzamides, anilides, alkenes, and even alkanes by triazole assistance in a chemo-, site- and diastereo-selective fashion.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
authors.forename: Karolina
authors.initials: K
authors.lastname: Graczyk
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/
authors.forename: Tobias
authors.initials: T
authors.lastname: Haven
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077 Göttingen (Germany) http://www.ackermann.chemie.uni-goettingen.de/. Lutz.Ackermann@chemie.uni-goettingen.de.
authors.forename: Lutz
authors.initials: L
authors.lastname: Ackermann
mesh_terms: D000577:Amides / Q000737:chemistry*; D000813:Anilides / Q000737:chemistry*; D002384:Catalysis; D007501:Iron / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
chemical_list: D000577:Amides; D000813:Anilides; D007501:Iron
keywords: CH activation; amides; drug design; iron; synthetic methods