title: Meta-analytical association between angiotensin-converting enzyme gene polymorphisms and sarcoidosis risk.
abstract: Previous reports identified an association between sarcoidosis and an insertion/deletion (I/D) polymorphism in angiotensin-converting enzyme. Our meta-analysis of articles published between March 1996 and June 2013 identified studies in the PubMed, EMBASE, and the China National Knowledge Infrastructure databases. We examined whether angiotensin-converting enzyme polymorphisms influence sarcoidosis susceptibility. The strength of the association between I/D polymorphisms and sarcoidosis risk was measured based on the odds ratio and 95% confidence interval. Analysis was based on recessive and dominant models. Ethnic subgroup analysis from 18 articles (1882 cases and 3066 controls) showed that DD homozygote carriers were at a slightly increased risk of sarcoidosis compared with II homozygotes and DI heterozygotes (P = 0.03). Comparison of DD plus DI vs II revealed no significant association with sarcoidosis in group and ethnic subgroup analysis. We found that the I/D polymorphism in the angiotensin-converting enzyme gene was not associated with a major risk of sarcoidosis.
authors.affiliation: Department of Respiratory Medicine, The Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
authors.forename: R
authors.initials: R
authors.lastname: Zhu
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: L Q
authors.initials: LQ
authors.lastname: Bi
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: H
authors.initials: H
authors.lastname: Kong
authors.affiliation: Pulmonary Immunobiology Laboratory, University of North Carolina, Chapel Hill, NC, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Tilley
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China wpxie@njmu.edu.cn.
authors.forename: W P
authors.initials: WP
authors.lastname: Xie
mesh_terms: D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012507:Sarcoidosis / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A