title: Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups.
abstract: Lactotransferrin, also known as lactoferrin, is an iron binding glycoprotein that displays antiviral activity against many different infectious agents, including human immunodeficiency virus (HIV)-1. Lactotransferrin is present in the breast milk and in the female genitourinary mucosa and it has been hypothesised as a possible candidate to prevent mother-to-child HIV-1 transmission. To verify if two functional polymorphisms, Thr29Ala and Arg47Lys, in the lactotransferrin encoding gene (LTF) could affect HIV-1 infection and vertical transmission, a preliminary association study was performed in 238 HIV-1 positive and 99 HIV-1 negative children from Brazil, Italy, Africa and India. No statistically significant association for the Thr29Ala and Arg47Lys LTF polymorphisms and HIV-1 susceptibility in the studied populations was found. Additionally LTF polymorphisms frequencies were compared between the four different ethnic groups.
authors.affiliation: Institute for Maternal and Child Health, Scientific Institute For Research, Hospitalization and Care Burlo Garofolo, Trieste, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Zupin
authors.affiliation: Institute for Maternal and Child Health, Scientific Institute For Research, Hospitalization and Care Burlo Garofolo, Trieste, Italy.
authors.forename: Vania
authors.initials: V
authors.lastname: Polesello
authors.affiliation: Departamento de Genética, Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: Antonio Victor Campos
authors.initials: AV
authors.lastname: Coelho
authors.affiliation: Faculty of Medicine, National Institute of Health and Medical Research, University of Paris-Est Créteil, Créteil, France.
authors.forename: Michele
authors.initials: M
authors.lastname: Boniotto
authors.affiliation: Instituto de Medicina Integrada Prof Fernando Figueira, Recife, PE, Brasil.
authors.forename: Luiz Claudio
authors.initials: LC
authors.lastname: Arraes
authors.affiliation: Institute for Maternal and Child Health, Scientific Institute For Research, Hospitalization and Care Burlo Garofolo, Trieste, Italy.
authors.forename: Ludovica
authors.initials: L
authors.lastname: Segat
authors.affiliation: Institute for Maternal and Child Health, Scientific Institute For Research, Hospitalization and Care Burlo Garofolo, Trieste, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Crovella
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000208:ethnology / Q000635:transmission*; D000293:Adolescent; D001938:Brazil / Q000208:ethnology; D002648:Child; D015331:Cohort Studies; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D060005:Genotyping Techniques; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007194:India / Q000208:ethnology; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007558:Italy / Q000208:ethnology; D007781:Lactoferrin / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D012189:Retrospective Studies; D015030:Zimbabwe / Q000208:ethnology
chemical_list: D007781:Lactoferrin