title: An Injectable, Self-Healing Hydrogel to Repair the Central Nervous System.
abstract: An injectable, self-healing hydrogel (≈1.5 kPa) is developed for healing nerve-system deficits. Neurosphere-like progenitors proliferate in the hydrogel and differentiate into neuron-like cells. In the zebrafish injury model, the central nervous system function is partially rescued by injection of the hydrogel and significantly rescued by injection of the neurosphere-laden hydrogel. The self-healing hydrogel may thus potentially repair the central nervous system.
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
authors.forename: Ting-Chen
authors.initials: TC
authors.lastname: Tseng
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tao
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
authors.forename: Fu-Yu
authors.initials: FY
authors.lastname: Hsieh
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.
authors.forename: Yen
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli County, 35053, Taiwan, R.O.C.
authors.forename: Ing-Ming
authors.initials: IM
authors.lastname: Chiu
authors.affiliation: Institute of Polymer Science and Engineering, National Taiwan University, Taipei, 10617, Taiwan, R.O.C.
authors.forename: Shan-hui
authors.initials: SH
authors.lastname: Hsu
mesh_terms: D000464:Alginates / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002490:Central Nervous System / Q000166:cytology / Q000187:drug effects* / Q000293:injuries; D048271:Chitosan / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry / Q000494:pharmacology*; D007267:Injections; D055595:Mechanical Phenomena; D058953:Neural Stem Cells / Q000166:cytology / Q000187:drug effects; D015027:Zebrafish
chemical_list: D000464:Alginates; D001672:Biocompatible Materials; D006603:Hexuronic Acids; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D020723:Glucuronic Acid; D048271:Chitosan
keywords: injectable hydrogels; neural repair; neural stem cells; self-healing polymers