title: Anti-inflammatory and immunoregulatory functions of artemisinin and its derivatives.
abstract: Artemisinin and its derivatives are widely used in the world as the first-line antimalarial drug. Recently, growing evidences reveal that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. Meanwhile, researchers around the world are still exploring the unknown bioactivities of artemisinin derivatives. In this review, we provide a comprehensive discussion on recent advances of artemisinin derivatives affecting inflammation and autoimmunity, the underlying molecular mechanisms, and also drug development of artemisinins beyond antimalarial functions.
authors.affiliation: Laboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Chenchen
authors.initials: C
authors.lastname: Shi
authors.affiliation: Department of Orthopedics, Beijing Army General Hospital, Beijing, China.
authors.forename: Haipeng
authors.identifier: 0000-0001-7856-4488
authors.initials: H
authors.lastname: Li
authors.affiliation: Laboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Yifu
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Lifei
authors.identifier: 0000-0001-8975-7795
authors.initials: L
authors.lastname: Hou
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D000962:Antimalarials / Q000737:chemistry*; D037621:Artemisinins / Q000737:chemistry*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism; D007107:Immune System; D007166:Immunosuppressive Agents / Q000737:chemistry; D007249:Inflammation / Q000188:drug therapy; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D051379:Mice; D008822:Mice, Transgenic; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000962:Antimalarials; D037621:Artemisinins; D007166:Immunosuppressive Agents