title: Chryseobacterium indologenes in four patients with leukemia.
abstract: Chryseobacterium indologenes is a rare opportunistic pathogen causing hospital-acquired infection. We present 4 patients with leukemia associated with C. indologenes infection. Two of the patients, undergoing peripheral blood allogeneic hematopoietic stem cell transplantation (alloHSCT) from human leukocyte antigen-identical sibling donors, died of pneumonia caused by C. indologenes with or without Pseudomonas aeruginosa. Blood infection with C. indologenes was found in the other 2 patients during chemotherapy, 1 of which was a central venous catheter-related bloodstream infection. Both patients were cured with or without the sensitive antibiotic. Three of these 4 isolates were susceptible to trimethoprim-sulfamethoxazole only in vitro. Although C. indologenes has a weak toxicity, it can be lethal for the super-immunocompromised patients, such as those treated with alloHSCT.
authors.affiliation: Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: L
authors.initials: L
authors.lastname: Deng
authors.affiliation: Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: M F
authors.initials: MF
authors.lastname: Li
authors.affiliation: Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Li
authors.affiliation: Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: J L
authors.initials: JL
authors.lastname: Yang
authors.affiliation: Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
authors.forename: X
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000150:complications / Q000175:diagnosis; D055499:Catheter-Related Infections / Q000150:complications / Q000175:diagnosis*; D045247:Chryseobacterium / Q000302:isolation & purification*; D017809:Fatal Outcome; D005260:Female; D045826:Flavobacteriaceae Infections / Q000150:complications / Q000175:diagnosis*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D008297:Male; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis*; D018410:Pneumonia, Bacterial / Q000150:complications / Q000175:diagnosis
keywords: Chryseobacterium indologenes; immunosuppression; leukemia; transplantation