title: Weight gain in pregnancy, maternal age and gestational age in relation to fetal macrosomia.
abstract: To investigate the possible risk factors related to macrosomia. Pregnant women and their newborns (n = 1041) were recruited from a cohort study in Maternal and Child Care Center of Hefei from January 2011 to July 2012. Questionnaires were applied to collect the demographic data besides the medical records. Detailed health records of the entire pregnancy were obtained using retrospective study. Meanwhile the data of neonatal outcomes was prospectively tracked. Associations between exposure risk factors and macrosomia were analyzed using Pearson's chi squared test. Logistic regression models were used to assess the independent association between these potential predictors and macrosomia. The incidence of macrosomia of this cohort was 11.24% of which male: female = 2.55:1. Male incidence (8.07%) of macrosomia was higher than female (3.17%), p < 0.001. Body mass index (BMI) before pregnancy (pre-BMI), maternal height, parity were not independently associated with macrosomia; multiple logistic regression analysis indicated that macrosomia was mainly independently associated with weight gain in pregnancy (OR=1.14, 95% CI [1.10-1.19]), maternal age (OR = 1.09, 95% CI [1.03-1.15]) and gestational age (OR = 1.62, 95% CI [1.31-1.99]), respectively. Our findings indicate that weight gain in pregnancy, maternal age and gestational age should be considered as independent risk factors for macrosomia.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Anhui 230032, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Anhui 230032, PR China.
authors.forename: Qi-Fei
authors.initials: QF
authors.lastname: Liu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Anhui 230032, PR China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Anhui 230032, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Anhui 230032, PR China.
authors.forename: Kui
authors.initials: K
authors.lastname: Ye
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Anhui 230032, PR China.
authors.forename: Han-Lin
authors.initials: HL
authors.lastname: Lai
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Anhui 230032, PR China.
authors.forename: Hai-Qing
authors.initials: HQ
authors.lastname: Wang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Anhui 230032, PR China.
authors.forename: Chuan-Lai
authors.initials: CL
authors.lastname: Hu
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Anhui 230032, PR China.
authors.forename: Qi-Hong
authors.initials: QH
authors.lastname: Zhao
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Anhui 230032, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
keywords: Body mass index; Fetal macrosomia; Pregnancy; Risk factors