title: Radiation-induced Chondrosarcoma of the Bladder. Case Report and Review of Literature.
abstract: BACKGROUND
  Chondrosarcoma of the bladder is an extremely rare disease. Only five previously described cases are known in the medical literature.
  
  
  METHODS
  We present a chondrosarcoma developed 19 years after radiation treatment in a 73-year-old patient. A literature search of articles published from 1984 to 2014 was performed.
  
  
  RESULTS
  This is the first reported case of post-radiation bladder chondrosarcoma. We compared the clinicopathological features of the previously reported cases and reviewed the medical literature of the bladder sarcomas and post-radiation sarcomas.
  
  
  CONCLUSIONS
  The primary treatment for bladder mesenchymal neoplasms is surgical, preferably radical cystectomy with or without chemotherapy. Positive surgical margin is one of the most important factors negatively affecting disease-specific, recurrence-free and overall survival rates.
authors.affiliation: Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A. Norbert.Sule@RoswellPark.org.
authors.forename: Norbert
authors.initials: N
authors.lastname: Sule
authors.affiliation: Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A.
authors.forename: B O
authors.initials: BO
authors.lastname: Xu
authors.affiliation: Department of Pathology and Anatomical Sciences, University at Buffalo, Buffalo, NY, U.S.A.
authors.forename: Dima
authors.initials: D
authors.lastname: El Zein
authors.affiliation: Department of Neurology, University at Buffalo, Buffalo, NY, U.S.A.
authors.forename: Kinga
authors.initials: K
authors.lastname: Szigeti
authors.affiliation: Department of Medical Oncology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A.
authors.forename: Saby
authors.initials: S
authors.lastname: George
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A.
authors.forename: John M
authors.initials: JM
authors.lastname: Kane
authors.affiliation: Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, U.S.A.
authors.forename: Richard
authors.initials: R
authors.lastname: Cheney
mesh_terms: D000368:Aged; D002813:Chondrosarcoma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy
keywords: Bladder chondrosarcoma; postradiation sarcoma