title: Retrospective evaluation of pubertal development and linear growth of girls with Turner Syndrome treated with oral and transdermal estrogen.
abstract: OBJECTIVE
  The objective of the study was to evaluate the pubertal development and linear growth of Turner Syndrome (TS) girls regularly monitored in our department.
  
  
  METHODS
  The data of 13 patients with TS were evaluated retrospectively. Left hand radiograms were evaluated by three different pediatric endocrinologists to determine bone ages.
  
  
  RESULTS
  Six (46.2%) of the TS girls were treated with oral estrogens, while 7 (53.8%) were treated with transdermal estrogen. The ratios of chronological age (CA) difference to bone age (BA) difference (ΔCA/ΔBA) in two groups of patients treated with estrogen were compared at the time of the last control. The ΔCA/ΔBA ratio in the transdermal estrogen-treated group was significantly higher (p=0.005). These results suggest slower BA progression in the TS girls treated with transdermal estrogen.
  
  
  CONCLUSIONS
  BA advancement is less significant with transdermal estrogen, which is associated with adequate breast development.
authors.forename: Esra D P
authors.initials: ED
authors.lastname: Çakır
authors.forename: Halil
authors.initials: H
authors.lastname: Sağlam
authors.forename: Erdal
authors.initials: E
authors.lastname: Eren
authors.forename: Taner
authors.initials: T
authors.lastname: Özgür
authors.forename: Ömer F
authors.initials: ÖF
authors.lastname: Tarım
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000293:Adolescent; D001827:Body Height / Q000187:drug effects* / Q000502:physiology; D002648:Child; D004958:Estradiol / Q000008:administration & dosage / Q000627:therapeutic use*; D004967:Estrogens / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011627:Puberty / Q000187:drug effects* / Q000502:physiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D014424:Turner Syndrome / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D004967:Estrogens; D004958:Estradiol