title: Nasal nitric oxide in sleep-disordered breathing in children.
abstract: BACKGROUND
  Inflammation plays a role in the pathogenesis and consequences of sleep-disordered breathing (SDB). The nasal mucosa and paranasal sinuses produce high levels of nitric oxide (NO). In asthma, exhaled NO is a marker of airway inflammation. There is only limited information whether nasal NO (nNO) accompanies also chronic upper airway obstruction, specifically, SDB. The objective of this study was to investigate nNO levels in children with SDB in comparison to healthy non-snoring children.
  
  
  METHODS
  Nasal NO was measured in children who underwent overnight polysomnographic studies due to habitual snoring and suspected SDB and in healthy non-snoring controls.
  
  
  RESULTS
  One hundred and eleven children participated in the study: 28 with obstructive sleep apnea (OSA), 60 with primary snoring (PS), and 23 controls. Nasal NO levels were significantly higher in children with OSA and PS compared to controls (867.4 ± 371.5, 902.0 ± 330.9, 644.1 ± 166.5 ppb, respectively, p = 0.047). No difference was observed between children with OSA and PS. No correlations were found between nNO levels and any of the PSG variables, nor with age, BMI percentile or tonsils size.
  
  
  CONCLUSIONS
  Compared to healthy controls, nNO is increased in children with SDB, but it is not correlated with disease severity. This is probably due to the local mechanical processes and snoring.
authors.affiliation: Department of Pediatric Pulmonology, Critical Care and Sleep Medicine, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler Faculty of Medicine, 6 Weizmann St., Tel Aviv, 64239, Israel. guyg@tlvmc.gov.il.
authors.forename: Guy
authors.initials: G
authors.lastname: Gut
authors.affiliation: Department of Pediatric Pulmonology, Critical Care and Sleep Medicine, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler Faculty of Medicine, 6 Weizmann St., Tel Aviv, 64239, Israel.
authors.forename: Riva
authors.initials: R
authors.lastname: Tauman
authors.affiliation: Department of Pediatric Pulmonology, Critical Care and Sleep Medicine, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler Faculty of Medicine, 6 Weizmann St., Tel Aviv, 64239, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Greenfeld
authors.affiliation: Department of Pediatric Pulmonology, Critical Care and Sleep Medicine, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler Faculty of Medicine, 6 Weizmann St., Tel Aviv, 64239, Israel.
authors.forename: Keren
authors.initials: K
authors.lastname: Armoni-Domany
authors.affiliation: Department of Pediatric Pulmonology, Critical Care and Sleep Medicine, Dana Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler Faculty of Medicine, 6 Weizmann St., Tel Aviv, 64239, Israel.
authors.forename: Yakov
authors.initials: Y
authors.lastname: Sivan
mesh_terms: D000293:Adolescent; D000402:Airway Obstruction / Q000175:diagnosis* / Q000276:immunology; D001944:Breath Tests; D002648:Child; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology; D009569:Nitric Oxide / Q000032:analysis*; D010256:Paranasal Sinuses / Q000276:immunology; D017286:Polysomnography; D012016:Reference Values; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000276:immunology; D013223:Statistics as Topic
chemical_list: D009569:Nitric Oxide
keywords: Inflammation; Nasal nitric oxide; Obstructive sleep apnea; Primary snoring; Sleep-disordered breathing