title: Clinical correlation between a point-of-care testing system and laboratory automation for lipid profile.
abstract: BACKGROUND
  We evaluated the clinical correlation between the CardioChek PA analyzer and a clinical laboratory reference method to use for screening program purposes.
  
  
  METHODS
  Fasting blood samples were collected on 516 patients (age 20-85 y). One venous sample was collected using a serum tube for the evaluation on a COBAS reference analyzer. A second venous sample was collected in a lithium heparin tube and was evaluated on the CardioChek PA analyzer (CCPA venous). A fingerstick sample (CCPA fingerstick) was evaluated only on the CardioChek PA analyzer. Linear regression analyses were performed for each measured analyte, total cholesterol, HDL-cholesterol and triglycerides.
  
  
  RESULTS
  The correlation between the CCPA fingerstick and CCPA venous was extremely high for HDL-C and triglycerides, and good for total cholesterol. Our results demonstrated a good clinical agreement for total cholesterol, HDL-C and triglycerides between 97.7% and 94.6% in the comparison of the CCPA to the reference analyzer.
  
  
  CONCLUSIONS
  We identified the pre-analytic phase as an important step to guarantee the quality of results and indicate that the CardioChek PA is a reliable lipid point-of-care testing system that can be used for the application of clinical screening anywhere.
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil; Federal University of São Paulo - UNIFESP, São Paulo, Brazil. Electronic address: carlos.ferreira@einstein.br.
authors.forename: Carlos Eduardo dos Santos
authors.initials: CE
authors.lastname: Ferreira
authors.affiliation: Federal University of São Paulo - UNIFESP, São Paulo, Brazil; University of Santo Amaro - UNISA, São Paulo, Brazil.
authors.forename: Carolina Nunes
authors.initials: CN
authors.lastname: França
authors.affiliation: Federal University of Paraná, Curitiba, Brazil.
authors.forename: Cassyano Januário
authors.initials: CJ
authors.lastname: Correr
authors.affiliation: ZIVD, LLC, Metuchen, NJ, USA.
authors.forename: Márcia L
authors.initials: ML
authors.lastname: Zucker
authors.affiliation: Federal University of São Paulo - UNIFESP, São Paulo, Brazil.
authors.forename: Adagmar
authors.initials: A
authors.lastname: Andriolo
authors.affiliation: Federal University of Paraná, Curitiba, Brazil.
authors.forename: Marileia
authors.initials: M
authors.lastname: Scartezini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057205:Automation, Laboratory / Q000592:standards*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis; D008076:Cholesterol, HDL / Q000097:blood*; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D000067716:Point-of-Care Testing / Q000592:standards*; D017410:Practice Guidelines as Topic; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides
keywords: CardioChek PA; Cardiovascular diseases; Point-of-care testing