title: [Cytogenetic investigations of bone marrow cells from mice exposed onboard biosatellite "Bion-M1"].
abstract: The results of studying the mitotic activities and chromosomal aberrations in bone marrow cells from C57/BL6N mice with the help of the anaphase technique in 12 hours after completion of the 30-day "Bion-M1" mission and ground-based experiment using flight equipment are presented. A statistically reliable decline of the mitotic activity (0.74%) was found in cells taken from the space flown animals. In the ground-based experiment, a statistically reliable downward trend in proliferative activity (1.37%) was revealed after the comparison with groups of vivarium control (1.46-1.53%). In both experiments mice increased the number of initial mitotic phases (prophase + metaphase) relative to the sum of anaphases and telophases. The number of aberrant mitoses grew reliably in the group of flight animals by 29.7%, whereas in the ground-based experiment an upward trend was insignificant as their number increased up to 2.3% only. In the vivarium controls aberrant mitoses constituted 1.75-1.8%. An increase in chromosomal aberrations was largely due to such abnormalities as fragments. These findings seem to have been a result of summation of the effects of radiation and other stressful factors in space flight.
authors.forename: O V
authors.initials: OV
authors.lastname: Dorozhkina
authors.forename: A A
authors.initials: AA
authors.lastname: Ivanov
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology* / Q000473:pathology; D002869:Chromosome Aberrations; D003359:Cosmic Radiation / Q000009:adverse effects*; D020732:Cytogenetic Analysis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008938:Mitosis / Q000502:physiology*; D013026:Space Flight; D018531:Spacecraft