title: Useful agents against aflatoxin B1 - antibacterial azomethine and Mn(III) complexes involving L-Threonine, L-Serine, and L-Tyrosine.
abstract: The present study is focused on evaluating the antimutagenic properties of Schiff bases and Mn(III) complexes with L-Threonine, L-Serine and L-Tyrosine, which have antimicrobial activity. These six compounds were investigated for antimutagenic properties against Aflatoxin Bı (AFBı) by the micronucleus (MN) assay in a human lymphocyte cell culture in vitro. The protective role of these compounds against AFBı-induced MN is probably related to its doses. A mechanism has been proposed to reduce the effect of AFBı.
authors.affiliation: a Department of Molecular Biology and Genetics , Ataturk University , Erzurum , Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Anar
authors.affiliation: b Department of Chemistry , Gazi University , Ankara , Turkey.
authors.forename: Elvan Hasanoğlu
authors.initials: EH
authors.lastname: Özkan
authors.affiliation: c Department of Biology , Ahi Evran University , KırŞehir , Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Öğütçü
authors.affiliation: a Department of Molecular Biology and Genetics , Ataturk University , Erzurum , Turkey.
authors.forename: Güleray
authors.initials: G
authors.lastname: Ağar
authors.affiliation: d Department of Chemistry , Ankara University , Turkey.
authors.forename: İffet
authors.initials: İ
authors.lastname: Şakıyan
authors.affiliation: b Department of Chemistry , Gazi University , Ankara , Turkey.
authors.forename: NurŞen
authors.initials: N
authors.lastname: Sarı
mesh_terms: D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors / Q000633:toxicity; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000931:Antidotes / Q000737:chemistry / Q000494:pharmacology; D001391:Azo Compounds / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000254:growth & development; D005260:Female; D006801:Humans; D008297:Male; D008345:Manganese / Q000737:chemistry / Q000494:pharmacology; D012694:Serine / Q000737:chemistry / Q000494:pharmacology; D013882:Thiosemicarbazones / Q000737:chemistry / Q000494:pharmacology; D013912:Threonine / Q000737:chemistry / Q000494:pharmacology; D014443:Tyrosine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000931:Antidotes; D001391:Azo Compounds; D013882:Thiosemicarbazones; C512188:azomethine; D013912:Threonine; D014443:Tyrosine; D008345:Manganese; D012694:Serine; D016604:Aflatoxin B1
keywords: Mn(III) complexes; aflatoxin Bı; antimicrobial properties; mutagenicity