title: Antioxidant status in blood of gynaecological patients: influence of diagnosis and reproductive factors.
abstract: Cancer of the reproductive tract is an important cause of morbidity and mortality among women worldwide. In this study we evaluated the influence of diagnostic categories, age and reproductive factors on antioxidant enzymes and lipid hydroperoxides in the blood of gynaecological patients diagnosed with endometrial polyp, myoma, hyperplasia simplex, hyperplasia complex and endometrial adenocarcinoma. Multivariate regression analysis was used to assess the association of diagnosis, age, parity, abortions and abnormal uterine bleeding with the examined parameters. Diagnosis provided the best predictive model for superoxide dismutase, catalase and glutathione peroxidase activities, and also for the lipid hydroperoxide level. Abortions fitted the best predictive model for superoxide dismutase activity. A significant correlation was also found between the predictor variables themselves. This study showed that reproductive and other factors may be associated, at least partially, with antioxidant capacity and ability to defend against the oxidative damage in gynaecological patients with various diagnoses.
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, "Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
authors.forename: S
authors.initials: S
authors.lastname: Pejić
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, "Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
authors.forename: V
authors.initials: V
authors.lastname: Stojiljković
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, "Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
authors.forename: A
authors.initials: A
authors.lastname: Todorović
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, "Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
authors.forename: L
authors.initials: L
authors.lastname: Gavrilović
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, "Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
authors.forename: N
authors.initials: N
authors.lastname: Popović
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, "Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
authors.forename: I
authors.initials: I
authors.lastname: Pavlović
authors.affiliation: Laboratory of Molecular Biology and Endocrinology, "Vinča" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
authors.forename: S B
authors.initials: SB
authors.lastname: Pajović
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D005260:Female; D005831:Genital Diseases, Female / Q000097:blood* / Q000175:diagnosis* / Q000201:enzymology; D006801:Humans; D008054:Lipid Peroxides; D008875:Middle Aged; D012044:Regression Analysis; D012098:Reproduction; D013482:Superoxide Dismutase
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D002374:Catalase; D013482:Superoxide Dismutase