title: Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.
abstract: How is information communicated both within and between cells of living systems with high signal to noise? We discuss transmembrane signaling models involving two receptor tyrosine kinases: the fibroblast growth factor receptor (FGFR) and the MET receptor. We suggest that simple dimerization models might occur opportunistically giving rise to noise but cooperative clustering of the receptor tyrosine kinases observed in these systems is likely to be important for signal transduction. We propose that this may be a more general prerequisite for high signal to noise in transmembrane receptor signaling.
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.
authors.forename: Michal
authors.initials: M
authors.lastname: Blaszczyk
authors.affiliation: The Henry Wellcome Building for Biocatalysis, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Harmer
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK.
authors.forename: Dimitri Y
authors.initials: DY
authors.lastname: Chirgadze
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK. Electronic address: dascher@svi.edu.au.
authors.forename: David B
authors.initials: DB
authors.lastname: Ascher
authors.affiliation: Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK. Electronic address: tlb20@cam.ac.uk.
authors.forename: Tom L
authors.initials: TL
authors.lastname: Blundell
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D055503:Protein Multimerization; D019859:Proto-Oncogene Proteins c-met / Q000737:chemistry* / Q000378:metabolism*; D017468:Receptors, Fibroblast Growth Factor / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D017468:Receptors, Fibroblast Growth Factor; D019859:Proto-Oncogene Proteins c-met
keywords: Cell signaling; FGFR; MET receptor; Signal to noise; Transmembrane receptors