title: Glycosaminoglycan and versican deposits in taxane-induced sclerosis.
abstract: Docetaxel and paclitaxel are widely used in the treatment of various malignant neoplasms. Taxane-induced sclerosis is dose-dependent and usually not generalized. Little information on the pathogenesis of scleroderma is currently available. Here, we report a case of generalized scleroderma and a case of early-stage oedematous sclerosis, both of which presented with intense versican deposits after administration of taxane for angiosarcoma.
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
authors.forename: K
authors.identifier: http://orcid.org/0000-0001-9455-5960
authors.initials: K
authors.lastname: Okada
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Endo
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
authors.affiliation: Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Koike
authors.affiliation: Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kuwatsuka
authors.affiliation: Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Utani
mesh_terms: D000077143:Docetaxel; D006025:Glycosaminoglycans / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006394:Hemangiosarcoma / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012535:Scalp / Q000473:pathology*; D012594:Scleroderma, Localized / Q000139:chemically induced*; D012598:Sclerosis / Q000139:chemically induced; D012878:Skin Neoplasms / Q000188:drug therapy; D043823:Taxoids / Q000009:adverse effects*; D053675:Versicans / Q000378:metabolism*
chemical_list: D006025:Glycosaminoglycans; D043823:Taxoids; D053675:Versicans; D000077143:Docetaxel