title: Peripheral blood stem cell transplantation improves liver functional reserve.
abstract: BACKGROUND
  Currently available treatment options for decompensated hepatitis B-induced liver cirrhosis are limited and largely ineffective. Recently, stem cell transplantation has emerged as a promising treatment for cirrhosis. The aim of this study was to determine whether autologous peripheral blood stem cell transplantation can improve liver functional reserve in patients with hepatitis B-induced cirrhosis.
  
  
  METHODS
  In this study, 51 patients with hepatitis B-induced liver cirrhosis were assigned to the treatment group (n=23) or the control group (n=28). The treatment group underwent autologous peripheral blood stem cell transplantation in addition to comprehensive medical treatment, and the control group received comprehensive medical treatment alone. Liver functional reserve was monitored for 48 weeks after autologous peripheral blood stem cell transplantation.
  
  
  RESULTS
  After transplantation, most patients showed improvements in symptoms such as fatigue, anorexia, and abdominal distension. The retention rate of indocyanine green at 15 minutes, a common indicator of liver functional reserve, declined from 41.99±4.68 at baseline to 37.79±3.75 by 48 weeks after transplantation, showing significant improvement.
  
  
  CONCLUSIONS
  Autologous peripheral blood stem cell transplantation can improve several markers of liver health and liver functional reserve and is a promising prospect for clinical application.
authors.affiliation: Department of Infectious Diseases, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China (mainland).
authors.forename: Ting
authors.initials: T
authors.lastname: Cai
authors.affiliation: Department of Infectious Diseases, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China (mainland).
authors.forename: Qinzhi
authors.initials: Q
authors.lastname: Deng
authors.affiliation: Stem Cell Laboratory, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China (mainland).
authors.forename: Shun
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Department of Research and Teaching, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China (mainland).
authors.forename: Airong
authors.initials: A
authors.lastname: Hu
authors.affiliation: Department of Epidemiological Survey, Ningbo Center for Disease Control and Prevention, Ningbo, Zhejiang, China (mainland).
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Gong
authors.affiliation: Department of infectious diseases, Ningbo No. 2 Hospital, Ningbo, China (mainland).
authors.forename: Xingfen
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000855:Anorexia / Q000209:etiology; D015415:Biomarkers; D005221:Fatigue / Q000209:etiology; D005260:Female; D005456:Fluorescent Dyes / Q000493:pharmacokinetics; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D019650:Hematopoietic Stem Cell Mobilization; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications*; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D008099:Liver / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000097:blood / Q000209:etiology / Q000628:therapy*; D017093:Liver Failure / Q000209:etiology / Q000517:prevention & control*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D063189:Symptom Assessment; D014182:Transplantation, Autologous
chemical_list: D015415:Biomarkers; D005456:Fluorescent Dyes; D016179:Granulocyte Colony-Stimulating Factor; D007208:Indocyanine Green