title: Current role of multiparametric magnetic resonance imaging in the management of prostate cancer.
abstract: The purpose of this review was to evaluate the current role of multiparametric magnetic resonance imaging (mp-MRI) in the management of prostate cancer (PC). The diagnosis of PC remains controversial owing to overdetection of indolent disease, which leads to overtreatment and subsequent patient harm. mp-MRI has the potential to equilibrate the imbalance between detection and treatment. The limitation of the data for analysis with this new technology is problematic, however. This issue has been compounded by a paradigm shift in clinical practice aimed at utilizing this modality, which has been rolled out in an ad hoc fashion often with commercial motivation. Despite a growing body of literature, pertinent clinical questions remain. For example, can mp-MRI be calibrated to reliably detect biologically significant disease? As with any new technology, objective evaluation of the clinical applications of mp-MRI is essential. The focus of this review was on the evaluation of mp-MRI of the prostate with respect to clinical utility.
authors.affiliation: Department of Surgery, Austin Hospital, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Nikolas Christopher
authors.initials: NC
authors.lastname: Katelaris
authors.affiliation: Department of Surgery, Austin Hospital, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Damien Michael
authors.initials: DM
authors.lastname: Bolton
authors.affiliation: Department of Surgery, Austin Hospital, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Mahesha
authors.initials: M
authors.lastname: Weerakoon
authors.affiliation: Department of Surgery, Austin Hospital, University of Melbourne, Melbourne, VIC, Australia.
authors.forename: Liam
authors.initials: L
authors.lastname: Toner
authors.affiliation: Sydney Adventist Hospital, Sydney, NSW, Australia.
authors.forename: Phillip Mark
authors.initials: PM
authors.lastname: Katelaris
authors.affiliation: Department of Surgery, Austin Hospital, University of Melbourne, Melbourne, VIC, Australia. ; Olivia Newton-John Cancer Research Institute, Austin Hospital, Heidelberg, VIC, Australia. ; Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
authors.forename: Nathan
authors.initials: N
authors.lastname: Lawrentschuk
mesh_terms: D019468:Disease Management; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D017430:Prostate-Specific Antigen
keywords: Diagnosis; Magnetic resonance imaging; Pathology; Prostatic neoplasms; Urology