title: [Correlation of the Desialylation of Platelets with Efficacy of the First-line Therapy for ITP].
abstract: OBJECTIVE
  To detect desialylation of platelets in primary immune thrombocytopenia(ITP) patients with FITC-labelled ECL and RCA-1, and compare the correlation of the desialylation level and the efficacy of first-line therapy for ITP.
  
  
  METHODS
  Before treatment, 48 ITP patients were selected and their levels of ECL and RCA-1 were detected with flow cytometry.
  
  
  RESULTS
  The desialylation level in the different efficacy groups by using the first-line therapy of corticosteroids and (or) intravenous immunoglobulin G (IVIG) had a statistically significant difference (P<0.05). The correlation analysis showed negative relation of the therapeutic efficacy with desialylation level, that is to say, the more high of desialylation level, the more poor therapeutic efficacy of the first-line therapy.
  
  
  CONCLUSIONS
  The desialylation level of platelets in ITP patients is related with the first-line therapeutic efficacy, the efficacy for patients with high desialylation level is poor, suggesting that the FcR-independent pathway exists in clearance of platelets in ITP patients. Therefore, the desialylation level of platelets may suggest the first-line therapeutic efficacy for ITP patients to a certain degree, and may be used as a potential target for the treatment of refractory ITP.
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Anhui Medical University (Hematological Research Center of Anhui Medical University), Hefei 230601, Anhui Province, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Tao
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Anhui Medical University (Hematological Research Center of Anhui Medical University), Hefei 230601, Anhui Province, China.
authors.forename: Jia-Jia
authors.initials: JJ
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Anhui Medical University (Hematological Research Center of Anhui Medical University), Hefei 230601, Anhui Province, China.
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Wang
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Anhui Medical University (Hematological Research Center of Anhui Medical University), Hefei 230601, Anhui Province, China.
authors.forename: Qian-Shan
authors.initials: QS
authors.lastname: Tao
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Qing-Shu
authors.initials: QS
authors.lastname: Zeng
authors.affiliation: Department of Laboratorial Medicine and Pathobiology, University of Toronto, CANADA M2J46A.
authors.forename: He-Yu
authors.initials: HY
authors.lastname: Ni
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Anhui Medical University (Hematological Research Center of Anhui Medical University), Hefei 230601, Anhui Province, China. E-mail: zzzm889@163.com.
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Zhai
mesh_terms: D000305:Adrenal Cortex Hormones; D001792:Blood Platelets; D005434:Flow Cytometry; D006801:Humans; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D016553:Purpura, Thrombocytopenic, Idiopathic
chemical_list: D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous