title: ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation.
abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a complex etiology and pathology that makes the development of new therapies difficult. ACTH has neurotrophic and myotrophic effects, but has not been tested in an ALS mouse model. The G93A-SOD1 mouse model of ALS was used to test the ability of this drug to delay ALS-like symptoms. We showed that within a specific dose range, ACTH significantly postponed the disease onset and paralysis in the mouse model. To our surprise and of greater significance is that ACTH significantly reduced the levels of soluble SOD1 in the spinal cord and CNS tissues of G93A-SOD1 treated mice as well as cultured fibroblasts.
authors.affiliation: Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, United States of America.
authors.forename: Hasan
authors.initials: H
authors.lastname: Arrat
authors.affiliation: Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, United States of America.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Lukas
authors.affiliation: Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, 60611, United States of America.
authors.forename: Teepu
authors.initials: T
authors.lastname: Siddique
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002460:Cell Line; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000187:drug effects; D009046:Motor Neurons / Q000378:metabolism; D009154:Mutation; D013116:Spinal Cord / Q000378:metabolism; D013482:Superoxide Dismutase / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D000072105:Superoxide Dismutase-1; D015996:Survival Rate
chemical_list: C000606290:SOD1 protein, human; D000324:Adrenocorticotropic Hormone; C000606291:Sod1 protein, mouse; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1