title: Mitochondrial responses to extreme environments: insights from metabolomics.
abstract: Humans are capable of survival in a remarkable range of environments, including the extremes of temperature and altitude as well as zero gravity. Investigation into physiological function in response to such environmental stresses may help further our understanding of human (patho-) physiology both at a systems level and in certain disease states, making it a highly relevant field of study. This review focuses on the application of metabolomics in assessing acclimatisation to these states, particularly the insights this approach can provide into mitochondrial function. It includes an overview of metabolomics and the associated analytical tools and also suggests future avenues of research.
authors.affiliation: Centre of Human & Aerospace Physiological Sciences, King's College London, London, UK.
authors.forename: Katie A
authors.initials: KA
authors.lastname: O'Brien
authors.affiliation: MRC Human Nutrition Research Unit, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, England ; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK.
authors.forename: Julian L
authors.initials: JL
authors.lastname: Griffin
authors.affiliation: Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Murray
authors.affiliation: Centre of Human & Aerospace Physiological Sciences, King's College London, London, UK ; Fibrosis Drug Performance Unit, GlaxoSmithKline Medicines Research Centre, Stevenage, UK.
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Edwards
keywords: Extreme environments; Metabolomics; Mitochondria