title: Plasma soluble vascular adhesion protein-1 concentration correlates with arterial stiffness: A cross-sectional study.
abstract: BACKGROUND
  Arterial stiffness is related to inflammation, oxidative stress, advanced glycation end products (AGEs), and endothelial dysfunction. Vascular adhesion protein-1 (VAP-1) is both as an adhesion molecule involving in inflammation and as an amine oxidase producing aldehyde and hydrogen peroxide involved in protein cross-linking, oxidative stress and endothelial injury.
  
  
  OBJECTIVE
  We explored the associations of plasma soluble VAP-1 (sVAP-1) with arterial stiffness.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Health Examination Center at the General Hospital of the Air Force in Beijing, China.
  
  
  METHODS
  568 Han Chinese healthy persons living in Beijing (aged 50.7 ± 8.0 years).
  
  
  METHODS
  sVAP-1 concentration was assessed by enzyme-linked immunosorbent assay. Arterial stiffness was measured as brachial-ankle pulse wave velocity (baPWV) on both left and right sides of the examinees, and the larger and the mean values were recorded. Cardiovascular risk factors were investigated.
  
  
  RESULTS
  sVAP-1 was significantly associated with maximal or mean baPWV in subjects of age ≥ 60 years after adjusting for baPWV-related confounders (β=36.922, p<0.05 or β=32.512, p<0.05) or after adjusting for all the variables (β=37.924, p<0.05 or β=33.193, p<0.05), but not in subjects of age <60 years. sVAP-1 had an independent and positive correlation with age (r=0.222, p<0.001).
  
  
  CONCLUSIONS
  Plasma sVAP-1, increased with age, is associated with arterial stiffness in older individuals. VAP-1 may be important mechanism for vascular aging.
authors.affiliation: Geriatric Institute, The General Hospital of the Air Force, PLA (The Chinese People's Liberation Army), 30# Fucheng Road, Haidian District, Beijing 100142, China.
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Chen
authors.affiliation: Clinical Laboratory Center, The General Hospital of the Air Force, PLA (The Chinese People's Liberation Army), 30# Fucheng Road, Haidian District, Beijing 100142, China.
authors.forename: Rui-Min
authors.initials: RM
authors.lastname: Zhao
authors.affiliation: Geriatric Institute, The General Hospital of the Air Force, PLA (The Chinese People's Liberation Army), 30# Fucheng Road, Haidian District, Beijing 100142, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Jin
authors.affiliation: Geriatric Institute, The General Hospital of the Air Force, PLA (The Chinese People's Liberation Army), 30# Fucheng Road, Haidian District, Beijing 100142, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Han
authors.affiliation: Health Examination Center, the General Hospital of the Air Force, PLA (The Chinese People's Liberation Army), 30# Fucheng Road, Haidian District, Beijing 100142, China.
authors.forename: Shu-Qiang
authors.initials: SQ
authors.lastname: Jiang
authors.affiliation: Health Examination Center, the General Hospital of the Air Force, PLA (The Chinese People's Liberation Army), 30# Fucheng Road, Haidian District, Beijing 100142, China.
authors.forename: Hai-Fang
authors.initials: HF
authors.lastname: Zheng
authors.affiliation: Geriatric Institute, The General Hospital of the Air Force, PLA (The Chinese People's Liberation Army), 30# Fucheng Road, Haidian District, Beijing 100142, China. Electronic address: kzdw66@sohu.com.
authors.forename: Jian-Chang
authors.initials: JC
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D055109:Ankle Brachial Index; D000068476:Beijing / Q000453:epidemiology; D001783:Blood Flow Velocity; D002318:Cardiovascular Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D015815:Cell Adhesion Molecules / Q000097:blood*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D015815:Cell Adhesion Molecules; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing)
keywords: Aging; Arterial stiffness; Semicarbazide-sensitive amine oxidase; Vascular adhesion protein-1