title: Prevalence of Beta-Cell, Thyroid and Celiac Autoimmunity in North Indian Children with Recent Onset Type 1 Diabetes (T1D).
abstract: There is wide variation in the prevalence of pancreatic and other major autoantibodies in different patient populations of Type 1 diabetes (T1D) across continents and even within countries. The data on frequency of associated autoimmunity Indian children with T1D is limited. A retrospective record review of 310 children aged 7.28±3.3 y (range 0.7-15 y) with recently diagnosed T1D attending our Pediatric Diabetes Clinic between April 2004 to September 2014, showed positivity for anti-GAD65, anti-IA2b, anti-TPO and anti-tTGA of 50% (64/128), 16% (12/72), 18.7% (23/123) and 22% (47/212) respectively. The male:female ratio in patients with anti-GAD, anti-TPO and anti-tTG positivity was 1.3, 0.7 and 0.6 respectively. In conclusion, our patient cohort exhibited a moderate prevalence of anti-GAD 65, low prevalence of anti-TPO and high prevalence of anti-tTGA autoantibodies as compared to previous reports. Male preponderance was noted in children with GAD65 positivity.
authors.affiliation: Additional Professor, Pediatric Endocrinology & Diabetes Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research , Chandigarh, India .
authors.forename: Devi
authors.initials: D
authors.lastname: Dayal
authors.affiliation: Registrar, Department of Pediatrics, Postgraduate Institute of Medical Education and Research , Chandigarh, India .
authors.forename: Madhusudan
authors.initials: M
authors.lastname: Samprati
authors.affiliation: Research Scholar, Department of Immunopathology, Postgraduate Institute of Medical Education and Research , Chandigarh, India .
authors.forename: Navchetan
authors.initials: N
authors.lastname: Kaur
authors.affiliation: Professor, Department of Immunopathology, Postgraduate Institute of Medical Education and Research , Chandigarh, India .
authors.forename: Ranjana Walker
authors.initials: RW
authors.lastname: Minz
authors.affiliation: Registrar, Department of Pediatrics, Postgraduate Institute of Medical Education and Research , Chandigarh, India .
authors.forename: Dhaarani
authors.initials: D
authors.lastname: Jayaraman
keywords: Autoantibodies; Children; Glutamic acid decarboxylase 65; Thyroid peroxidase; Tissue transglutaminase; Type 1 diabetes