title: Pregnancy outcomes in women with heart disease: Experience of a tertiary center in the Netherlands.
abstract: OBJECTIVE
  Clinical data of pregnant women with heart disease were obtained with the intention to provide input for local counseling and management guidelines.
  
  
  METHODS
  Retrospective data from all pregnant women with congenital or acquired heart disease between 2000 and 2011 in the VU University Medical Centre Amsterdam.
  
  
  METHODS
  Maternal and neonatal outcomes were evaluated.
  
  
  RESULTS
  Data of 122 women with 160 pregnancies were obtained. The most common heart diseases were congenital heart disease (n=65, 53.3%) and arrhythmia (n = 20, 16.4%). Based on the functional criteria of the New York Heart Association (NYHA), 114/122 patients (93.4%) were classified NYHA class I-II. Patients in NYHA class III-IV (n = 8/122, 6.6%), mainly had a history of myocardial infarction or pulmonary hypertension. There were 156 singleton and 4 twin pregnancies. 22 (13.5%) pregnancies were complicated by hypertensive disorders. Heart failure developed in 11 women (9.0%), 37.5% in NYHA class III-IV and 6.5% in NYHA class I-II. Mean gestational age and birth weight were 270 days and 3196 g in NYHA class I-II compared to 237 days and 1972 g for NHYA class III-IV. There were two maternal deaths (1.6%) and 5 fetal deaths (3.1%). There were 29 (12.8%) preterm births, 20 (12.8%) neonates small for gestational age and 34 (21.8%) admittances on the Neonatal Intensive Care Unit (NICU).
  
  
  CONCLUSIONS
  Pregnancy in women with pre-existing heart disease in all NYHA classes is associated with increased maternal morbidity and perinatal morbidity. Risk of structural fetal anomalies is especially high in women with congenital heart disease.
authors.affiliation: VU University Medical Centre, Boelelaan 1117, Department of Gynecology and Obstetrics, 1081 HZ Amsterdam, The Netherlands. Electronic address: e.hink@vumc.nl.
authors.forename: E
authors.initials: E
authors.lastname: Hink
authors.affiliation: VU University Medical Centre, Boelelaan 1117, Department of Gynecology and Obstetrics, 1081 HZ Amsterdam, The Netherlands. Electronic address: Annemieke.Bolte@radboudumc.nl.
authors.forename: A C
authors.initials: AC
authors.lastname: Bolte
mesh_terms: D000028:Abortion, Induced / Q000706:statistics & numerical data; D000328:Adult; D001724:Birth Weight; D036861:Delivery, Obstetric / Q000706:statistics & numerical data; D005260:Female; D006331:Heart Diseases / Q000453:epidemiology*; D006801:Humans; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology; D047928:Premature Birth / Q000453:epidemiology; D012189:Retrospective Studies; D055815:Young Adult
keywords: Heart disease; Maternal outcomes; Neonatal outcome; Pregnancy