title: Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood.
abstract: Maternal immune activation can result in different behavioral abnormalities and brain dysfunction, depending on the nature of the inflammogen and the timing of the challenge. Few studies report the possible link between prenatal exposure to inflammation and mood disorders. Here we aimed to evaluate the effects of a single low lipopolysaccharide (LPS) injection to the dam at gestational day 9 on the offspring behavior and hippocampal function. We found that mice exposed to LPS show anxiety- and depression-related behaviors. Specifically, we found that animals prenatally exposed to LPS avoided the open arms of an elevated plus maze, the center of an open field and the lit side of a light/dark box, and they spent more time immobile in both the forced swimming and tail suspension tests, when compared with offspring of saline-injected dams. In addition, LPS mice had reduced serotonin and noradrenaline levels in the hippocampus and diminished Reelin immunoreactivity in the dentate gyrus, while their adult hippocampal neurogenesis was not affected. Results presented here support specific long-term effects of the response to a bacterial immunogen early in pregnancy, as opposed to different effects previously reported of viral immunogens and/or responses in late pregnancy. Our work adds to recent reports and stresses the relevance of considering prenatal exposure to a maternal immune response as a risk factor for mood disorders.
authors.affiliation: Institute for Physiology, Molecular Biology and Neurosciences, CONICET-UBA, and Department of Physiology, Molecular and Cellular Biology, FCEyN, University of Buenos Aires, C1428EHA Buenos Aires, Argentina. Electronic address: adepino@conicet.gov.ar.
authors.forename: A M
authors.initials: AM
authors.lastname: Depino
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced / Q000209:etiology*; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism; D003863:Depression / Q000139:chemically induced / Q000209:etiology*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000150:complications*; D008070:Lipopolysaccharides; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009638:Norepinephrine / Q000032:analysis; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology* / Q000523:psychology*; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000378:metabolism; D012701:Serotonin / Q000032:analysis
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D008070:Lipopolysaccharides; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; D012701:Serotonin; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases; D009638:Norepinephrine
keywords: Reelin; maternal immune activation; mood disorders; neurogenesis; serotonin