title: Contrasting Sleeve Gastrectomy with Lifestyle Modification Therapy in the Treatment of Polycystic Ovary Syndrome.
abstract: OBJECTIVE
  To explore the feasibility of sleeve gastrectomy (SG) as a treatment for polycystic ovary syndrome (PCOS) and its potential to improve clinical efficacy in PCOS patients with symptoms of oligomenorrhea.
  
  
  METHODS
  Twenty-four obese patients with PCOS underwent laparoscopic SG. Simultaneously, 24 obese patients with PCOS received lifestyle modification therapy (LMT). Follow-ups were conducted at 3-6 months. Weight loss, menstruation, and improvements in hirsutism and metabolic symptoms were compared.
  
  
  RESULTS
  In the SG group, 20 patients were restored to normal menstrual cycles and ovulation at 3-6 months after surgery. Their average androgen levels decreased significantly following surgery (P=.012). Conversely, only 6 patients in the LMT group were restored to normal menstrual cycles and ovulation after receiving 3 months of treatment. Their average preoperative and postoperative androgen levels showed a nonstatistically significant decrease (P>.05). Compared with the LMT group, the SG group showed more pronounced improvements in menstruation. Additionally, body mass and body mass index were significantly reduced in patients in the SG group 3 months after the surgeries, with maximum weight loss observed at approximately 6 months after surgery. Patients who received LMT showed a gradual weight reduction such that body mass decreased significantly after 3 months (P<. 001). Compared with patients in the LMT group, patients in the SG group showed greater weight loss results (P<.0001).
  
  
  CONCLUSIONS
  In patients with PCOS, SG resulted in more marked weight loss and better improvements in clinical symptoms compared with LMT.
authors.affiliation: 1 Department of Gastroenterological Surgery, Shanghai Tongji Hospital, Tongji University School of Medicine , Shanghai, China .
authors.forename: Kaijing
authors.initials: K
authors.lastname: Wang
authors.affiliation: 2 Department of Gastroenterological Surgery, Shanghai East Hospital, Tongji University School of Medicine , Shanghai, China .
authors.forename: Qixin
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: 3 Department of Obstetrics and Gynecology, The Affiliated Hospital of Medical College, Qingdao University , Qingdao, China .
authors.forename: Yunqing
authors.initials: Y
authors.lastname: Zhi
authors.affiliation: 2 Department of Gastroenterological Surgery, Shanghai East Hospital, Tongji University School of Medicine , Shanghai, China .
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: 2 Department of Gastroenterological Surgery, Shanghai East Hospital, Tongji University School of Medicine , Shanghai, China .
authors.forename: Zhuqing
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: 2 Department of Gastroenterological Surgery, Shanghai East Hospital, Tongji University School of Medicine , Shanghai, China .
authors.forename: Yanting
authors.initials: Y
authors.lastname: Xie
authors.affiliation: 2 Department of Gastroenterological Surgery, Shanghai East Hospital, Tongji University School of Medicine , Shanghai, China .
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Yin
authors.affiliation: 2 Department of Gastroenterological Surgery, Shanghai East Hospital, Tongji University School of Medicine , Shanghai, China .
authors.forename: Aiguo
authors.initials: A
authors.lastname: Lu
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015928:Cognitive Behavioral Therapy; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D008019:Life Style; D009767:Obesity, Morbid; D011085:Polycystic Ovary Syndrome / Q000601:surgery / Q000628:therapy*; D016896:Treatment Outcome; D015431:Weight Loss; D055815:Young Adult