title: DNA repair genes XRCC1 and ERCC1 polymorphisms and the risk of sporadic breast cancer in Han women in the Gansu Province of China.
abstract: OBJECTIVE
  Polymorphisms in DNA damage repair genes may affect DNA repair capacity and modulate breast cancer susceptibility. In this study, we aimed to analyze two polymorphisms for each of the DNA repair genes X-ray repair cross-complementing group 1 (XRCC1) rs25487 and rs1799782 and excision repair cross-complementing group 1 (ERCC1) rs3212964 and rs11615, to evaluate their associations with the risk of sporadic breast cancer in Han women in the Gansu Province of China.
  
  
  METHODS
  Genotypes were determined by a polymerase chain reaction-based approach for 101 patients with breast cancer and in 101 disease-free controls.
  
  
  RESULTS
  We found that individuals with the AA genotype at XRCC1 rs25487 had a significantly increased risk of breast cancer compared with GG genotype (p<0.001, odds ratio [OR]=6.39, 95% confidence interval [CI]: 2.18-18.65). The dominant model showed that the combined rs25487 genotypes (AA+AG) increased the disease risk (p<0.001, OR=3.17, 95% CI: 1.76-5.72). However, no statistical associations were found between rs1799782 in XRCC1, or rs3212964 and rs11615 in ERCC1 and the risk of disease. In haplotype analysis, the GC haplotype in XRCC1 conferred an increased risk (p<0.001) with a 4.78-fold increase for each copy (95% CI: 2.52-8.72). Significant associations were also shown between the single nucleotide polymorphisms (SNPs) and the status of estrogen receptor (ER), progesterone receptor (PR), and HER-2.
  
  
  CONCLUSIONS
  The results suggest that the XRCC1 rs25487 polymorphism may increase the risk of breast cancer.
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .|2 School of Life Sciences, Lanzhou University , Lanzhou, China .
authors.forename: Gongjian
authors.initials: G
authors.lastname: Zhu
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Hongyun
authors.initials: H
authors.lastname: Guo
authors.affiliation: 3 Department of Chronic Disease Epidemiology, School of Public Health, School of Medicine, Yale Cancer Center, Yale University , New Haven, Connecticut.
authors.forename: Lingeng
authors.initials: L
authors.lastname: Lu
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Suisheng
authors.initials: S
authors.lastname: Yang
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Huan
authors.initials: H
authors.lastname: Guo
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Haitao
authors.initials: H
authors.lastname: Wang
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Jianping
authors.initials: J
authors.lastname: Min
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Xuezhong
authors.initials: X
authors.lastname: Chen
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: 4 Institute of Urology, The Second Hospital of Lanzhou University , Lanzhou, China .
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Wang
authors.affiliation: 1 Gansu Provincial Academy of Medical Sciences, Gansu Provincial Cancer Hospital , Lanzhou, People's Republic of China .
authors.forename: Haixiang
authors.initials: H
authors.lastname: Su
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; C071447:ERCC1 protein, human; D004720:Endonucleases