title: Cell adhesion and in vivo osseointegration of sandblasted/acid etched/anodized dental implants.
abstract: The authors describe a new type of titanium (Ti) implant as a Modi-anodized (ANO) Ti implant, the surface of which was treated by sandblasting, acid etching (SLA), and anodized techniques. The aim of the present study was to evaluate the adhesion of MG-63 cells to Modi-ANO surface treated Ti in vitro and to investigate its osseointegration characteristics in vivo. Four different types of Ti implants were examined, that is, machined Ti (control), SLA, anodized, and Modi-ANO Ti. In the cell adhesion study, Modi-ANO Ti showed higher initial MG-63 cell adhesion and induced greater filopodia growth than other groups. In vivo study in a beagle model revealed the bone-to-implant contact (BIC) of Modi-ANO Ti (74.20%±10.89%) was much greater than those of machined (33.58%±8.63%), SLA (58.47%±12.89), or ANO Ti (59.62%±18.30%). In conclusion, this study demonstrates that Modi-ANO Ti implants produced by sandblasting, acid etching, and anodizing improve cell adhesion and bone ongrowth as compared with machined, SLA, or ANO Ti implants. These findings suggest that the application of Modi-ANO surface treatment could improve the osseointegration of dental implant.
authors.affiliation: Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Korea. lohasdent@gmail.com.
authors.forename: Mu-Hyon
authors.initials: MH
authors.lastname: Kim
authors.affiliation: Division of Bioimaging, Chuncheon Center, Korea Basic Science Institute, Gangwon-do 200-701, Korea. kspark1223@hanmail.net.
authors.forename: Kyeongsoon
authors.initials: K
authors.lastname: Park
authors.affiliation: Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801, Korea. ckh@cowellmedi.com.
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Choi
authors.affiliation: Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801, Korea. ksh@cowellmedi.com.
authors.forename: Soo-Hong
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea. sen0223@gmail.com.
authors.forename: Se Eun
authors.initials: SE
authors.lastname: Kim
authors.affiliation: Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Korea. cmjeong@pusan.ac.kr.
authors.forename: Chang-Mo
authors.initials: CM
authors.lastname: Jeong
authors.affiliation: Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Korea. huhjb@pusan.ac.kr.
authors.forename: Jung-Bo
authors.initials: JB
authors.lastname: Huh
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D003758:Dental Implantation, Endosseous / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D015921:Dental Implants / Q000009:adverse effects*; D004285:Dogs; D006801:Humans; D016348:Osseointegration; D010006:Osteoblasts / Q000187:drug effects / Q000502:physiology*; D013499:Surface Properties; D014025:Titanium / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology
chemical_list: D015921:Dental Implants; D014025:Titanium