title: The Heart Protection Effect of Alcalase Potato Protein Hydrolysate Is through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets.
abstract: The prevalence of obesity is high in older adults. Alcalase potato protein hydrolysate (APPH), a nutraceutical food, might have greater benefits and be more economical than hypolipidemic drugs. In this study, serum lipid profiles and heart protective effects were evaluated in high fat diet (HFD) induced hyperlipidemia in aging rats treated with APPH (15, 45 and 75 mg/kg/day) and probucol (500 mg/kg/day). APPH treatments reduced serum triacylglycerol (TG), total cholesterol (TC), and low density lipoprotein (LDL) levels to the normal levels expressed in the control group. Additionally, the IGF1R-PI3K-Akt survival pathway was reactivated, and Fas-FADD (Fas-associated death domain) induced apoptosis was inhibited by APPH treatments (15 and 45 mg/kg/day) in HFD aging rat hearts. APPH (75 mg/kg/day) rather than probucol (500 mg/kg/day) treatment could reduce serum lipids without affecting HDL expression. The heart protective effect of APPH in aging rats with hyperlipidemia was through lowering serum lipids and enhancing the activation of the compensatory IGF1R-PI3K-Akt survival pathway.
authors.affiliation: PhD Program for Aging, China Medical University, Taichung 40402, Taiwan. duodenum222000@yahoo.com.tw.
authors.forename: Wei-Syun
authors.initials: WS
authors.lastname: Hu
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan. wei-jen.ting@outlook.com.
authors.forename: Wei-Jen
authors.initials: WJ
authors.lastname: Ting
authors.affiliation: Department of Food Science, College of Agriculture, Tunghai University, Taichung 40704, Taiwan. wdc@thu.edu.tw.
authors.forename: Wen-Dee
authors.initials: WD
authors.lastname: Chiang
authors.affiliation: Division of Cardiology, China Medical University Hospital, Taichung 40402, Taiwan. paidoctor1@gmail.com.
authors.forename: Peiying
authors.initials: P
authors.lastname: Pai
authors.affiliation: Department of Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan. 1867@cch.org.tw.|Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 35664, Taiwan. 1867@cch.org.tw.
authors.forename: Yu-Lan
authors.initials: YL
authors.lastname: Yeh
authors.affiliation: Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town 35053, Taiwan. changch@nhri.org.tw.
authors.forename: Chung-Ho
authors.initials: CH
authors.lastname: Chang
authors.affiliation: Department of Hospitality Management, College of Agriculture, Tunghai University, Taichung 40704, Taiwan. 040770@thu.edu.tw.
authors.forename: Wan-Teng
authors.initials: WT
authors.lastname: Lin
authors.affiliation: Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan. cyhuang@mail.cmu.edu.tw.|Graduate Institute of Chinese Medical Science, China Medical University, Taichung 40402, Taiwan. cyhuang@mail.cmu.edu.tw.|Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan. cyhuang@mail.cmu.edu.tw.
authors.forename: Chih-Yang
authors.initials: CY
authors.lastname: Huang
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017209:Apoptosis; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements; D053200:Fas-Associated Death Domain Protein / Q000378:metabolism; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000209:etiology; D008077:Lipoproteins, LDL / Q000097:blood; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010940:Plant Proteins / Q000737:chemistry; D011341:Probucol / Q000494:pharmacology; D011492:Protein Hydrolysates / Q000008:administration & dosage / Q000494:pharmacology*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D015398:Signal Transduction; D011198:Solanum tuberosum / Q000737:chemistry*; D013381:Subtilisins / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D002316:Cardiotonic Agents; D053200:Fas-Associated Death Domain Protein; D008077:Lipoproteins, LDL; D010940:Plant Proteins; D011492:Protein Hydrolysates; D014280:Triglycerides; D002784:Cholesterol; D019869:Phosphatidylinositol 3-Kinases; D017526:Receptor, IGF Type 1; D051057:Proto-Oncogene Proteins c-akt; D013381:Subtilisins; D011341:Probucol