title: Antimicrobial and osteogenic properties of silver-ion-implanted stainless steel.
abstract: Prevention of implant loosening and infection is crucial to orthopedic and dental surgeries. In this work, the surface of stainless steel (SS) was modified by silver-sourced plasma immersion ion implantation (Ag-PIII). Metallic silver nanoparticles with various diameters and distributions were fabricated on the SS surfaces after treatment with Ag-PIII for 0.5 and 1.5 h, respectively. The osteogenic activity and antimicrobial properties of SS before and after Ag-PIII treatment were evaluated using in vitro and in vivo tests. The results demonstrated that Ag-PIII treatment not only promoted the antibacterial activity of SS but also enhanced the osteogenic differentiation of human bone marrow stromal cells.
authors.affiliation: †Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Qin
authors.affiliation: §State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Huiliang
authors.initials: H
authors.lastname: Cao
authors.affiliation: †Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Yaochao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: §State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Jin
authors.affiliation: †Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Mengqi
authors.initials: M
authors.lastname: Cheng
authors.affiliation: †Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Jiaxin
authors.initials: J
authors.lastname: Wang
authors.affiliation: †Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: †Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Zhiquan
authors.initials: Z
authors.lastname: An
authors.affiliation: †Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Xianlong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: §State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
authors.forename: Xuanyong
authors.initials: X
authors.lastname: Liu
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D020450:Heavy Ions; D006801:Humans; D008422:Materials Testing; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D058626:Plasma Gases / Q000737:chemistry; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013193:Stainless Steel / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D000890:Anti-Infective Agents; D058626:Plasma Gases; D013193:Stainless Steel; D012834:Silver
keywords: antimicrobial; osteogenic; plasma immersion ion implantation; silver; stainless steel