title: Interventionalist perspective on the new endovascular trials.
abstract: Three recently published trials have conclusively proven the benefit of mechanical endovascular thrombectomy over best medical therapy for patients with acute ischemic stroke and large vessel occlusion. These trials shared some features and differed in others. These similarities and differences in trial design and execution affect the conclusions and recommendations that can be made from the data. We will examine the implications of these studies for neurointerventionists, both for current practice and for future studies. In particular, we will focus on procedural details such as patient selection, devices, adjunctive therapies, treatment time windows, and performance metrics.
authors.affiliation: From the Department of Neuroradiology, Hôpital Maison-Blanche, Reims, France (L.P.); and Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (C.D.).
authors.forename: Laurent
authors.initials: L
authors.lastname: Pierot
authors.affiliation: From the Department of Neuroradiology, Hôpital Maison-Blanche, Reims, France (L.P.); and Departments of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (C.D.). derdeync@wustl.edu.
authors.forename: Colin
authors.initials: C
authors.lastname: Derdeyn
mesh_terms: D002545:Brain Ischemia / Q000601:surgery*; D002986:Clinical Trials as Topic / Q000379:methods* / Q000592:standards*; D057510:Endovascular Procedures / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D020521:Stroke / Q000601:surgery*; D017131:Thrombectomy / Q000295:instrumentation / Q000379:methods*
keywords: clinical trial; editorial; stents; stroke