title: A stereological and histopathological study of the effects of exposure of male rat testes to mercury vapor.
abstract: Mercury is ubiquitous in the environment; it is an occupational pollutant and a potential toxicant. We investigated the effects of exposure of rat testes to mercury vapor (Hg(0)). Twelve male rats were divided into two groups of six: the rats of the Hg(0) group were exposed to mercury (1 mg/m(3)/day) in a chamber for six weeks; the control group rats were housed under the same conditions without exposure to Hg(0). After the experimental period, the testes were removed, sections of testis were evaluated histopathologically after hematoxylin and eosin staining, and stereologically using the Cavalieri principle and optical fractionator methods. We found significant decreases in the total volume of testis, diameters of seminiferous tubules and total volume of seminiferous tubules. Significant decreases were detected in the numbers of Sertoli cells, spermatogonia, spermatocytes and spermatids of the Hg(0) group compared to the control group. In the Hg(0) exposed group, spermatogenic cells were degenerated and seminiferous tubules were atrophied.
authors.affiliation: a Department of Histology and Embryology , Faculty of Medicine, Ondokuz Mayıs University , Samsun , Turkey.
authors.forename: M E
authors.initials: ME
authors.lastname: Altunkaynak
authors.affiliation: b Department of Restorative Dentistry , Faculty of Dentistry, Atatürk University , Erzurum , Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Akgül
authors.affiliation: a Department of Histology and Embryology , Faculty of Medicine, Ondokuz Mayıs University , Samsun , Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Yahyazadeh
authors.affiliation: a Department of Histology and Embryology , Faculty of Medicine, Ondokuz Mayıs University , Samsun , Turkey.
authors.forename: B Z
authors.initials: BZ
authors.lastname: Altunkaynak
authors.affiliation: a Department of Histology and Embryology , Faculty of Medicine, Ondokuz Mayıs University , Samsun , Turkey.
authors.forename: A P
authors.initials: AP
authors.lastname: Türkmen
authors.affiliation: c Department of Oral Diagnosis and Radiology , Faculty of Dentistry, Atatürk University , Erzurum , Turkey.
authors.forename: H M
authors.initials: HM
authors.lastname: Akgül
authors.affiliation: d Department of Histology and Embryology , Faculty of Medicine, Atatürk University , Erzurum , Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Aksak
authors.affiliation: d Department of Histology and Embryology , Faculty of Medicine, Atatürk University , Erzurum , Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Ünal
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000295:instrumentation; D008297:Male; D008628:Mercury / Q000633:toxicity*; D017207:Rats, Sprague-Dawley; D013087:Spermatids / Q000187:drug effects; D013090:Spermatocytes / Q000187:drug effects; D013737:Testis / Q000187:drug effects*
chemical_list: D008628:Mercury
keywords: histopathology; mercury vapor; rat; stereology; testis