title: A case of bilateral renal arterial thrombosis associated with cryocrystalglobulinaemia.
abstract: Cryocrystalglobulinaemia is an extremely rare complication of monoclonal gammopathy. Its presentation has features of both type I and II cryoglobulinaemia. Although peripheral and digital ischaemia is common, visceral ischaemia is rare. When it does occur, it is usually associated with multiple myeloma and has an extremely poor prognosis. We present a case of bilateral renal artery thrombosis associated with cryocrystalglobulinaemia in a patient without myeloma. More unusual, the cryocrystal protein in this case was associated with fibrinogen, which may have led to increased propensity towards thrombosis. Although the patient was unable to recover his kidney function, he remained alive on dialysis 2 years after the incident. The patient did not have any further ischaemic event despite no definitive therapy. This case represents an unusual presentation for this rare disease.
authors.affiliation: Division of Nephrology and Hypertension.
authors.forename: Nelson
authors.initials: N
authors.lastname: Leung
authors.affiliation: Division of Hematology, Mayo Clinic Rochester , Rochester, MN , USA.
authors.forename: Francis K
authors.initials: FK
authors.lastname: Buadi
authors.affiliation: Division of Hematology, Vancouver General Hospital.
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Song
authors.affiliation: Department of Pathology and Laboratory Medicine, St Paul's Hospital , Vancouver, BC , Canada.
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Magil
authors.affiliation: Division of Anatomic Pathology, Mayo Clinic Rochester , Rochester, MN , USA.
authors.forename: Lynn D
authors.initials: LD
authors.lastname: Cornell
keywords: cryocrystalglobulinaemia; crystal; monoclonal; renal artery thrombosis