title: Fibrillary glomerulonephritis with prevalent IgA deposition associated with undifferentiated connective tissue disease: A case report.
abstract: We described a 41-year-old female patient, who presented with proteinuria occurring 5 years after the onset of an undifferentiated connective tissue disease (UCTD). At renal biopsy, a pattern of focal necrotizing glomerulonephritis with mesangial and parietal deposition of the IgA, C3 and K chains was observed. Electron microscopy showed organized fibrillary deposits in mesangial, subendothelial, intramembranous and subepithelial sites. Fibrils were randomly arranged, had no hollow core and had a diameter ranging between 10 and 23 nm. This case showed a rare combination of fibrillary glomerulonephritis and prevalent IgA deposition, in the clinical context of UCTD.
authors.forename: Manuela
authors.initials: M
authors.lastname: Nebuloni
authors.affiliation: Nephrology Unit, 'L.Sacco' Hospital , Milan , Italy.
authors.forename: Augusto
authors.initials: A
authors.lastname: Genderini
authors.affiliation: Pathology Unit, L. Sacco Hospital.
authors.forename: Antonella
authors.initials: A
authors.lastname: Tosoni
authors.affiliation: Nephrology Unit, 'L.Sacco' Hospital , Milan , Italy.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Caruso
authors.affiliation: Nephrology Unit, 'L.Sacco' Hospital , Milan , Italy.
authors.forename: Giovanni Barbiano
authors.initials: GB
authors.lastname: di Belgiojoso
keywords: IgA nephropathy; electron microscopy; fibrillary glomerulonephritis; undifferentiated connective tissue disease