title: Functionally relevant RNA helicase mutations in familial and sporadic myeloid malignancies.
abstract: In this issue of Cancer Cell, Polprasert and colleagues identified recurrent mutations in the DEAD/H-box RNA helicase gene DDX41 in familial and acquired cases of myelodsyplasia and acute myeloid leukemia. These mutations induce defects in RNA splicing and represent a new class of mutations in myeloid malignancies.
authors.affiliation: Department of Cell Biology and Department of Medicine (Oncology), Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY 10461, USA.
authors.forename: Iléana
authors.initials: I
authors.lastname: Antony-Debré
authors.affiliation: Department of Cell Biology and Department of Medicine (Oncology), Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY 10461, USA. Electronic address: ulrich.steidl@einstein.yu.edu.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Steidl
mesh_terms: D000818:Animals; D053487:DEAD-box RNA Helicases / Q000235:genetics*; D005260:Female; D018095:Germ-Line Mutation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male
chemical_list: D053487:DEAD-box RNA Helicases