title: Differentiation of true-progression from pseudoprogression in glioblastoma treated with radiation therapy and concomitant temozolomide by GLCM texture analysis of conventional MRI.
abstract: Twenty-two patients with pathologically confirmed glioblastoma who had received concurrent CCRT with TMZ underwent conventional MRI including T1-weighted imaging(T1WI), T2-weighted imaging(T2WI), fluid attenuated inversion recovery(FLAIR)and contrast-enhanced T1WI(T1Ce). Five GLCM texture maps of contrast, energy, entropy, correlation and homogeneity were generated for each MRI series. Of the aforementioned 5 texture features, the most significant features were contrast and correlation on T2WI with areas under ROC curve of 0.883 and 0.892, respectively, and they had the same sensitivity of 75%, specificity of 100%, accuracy of 86.4%, PPV of 100% and NPV of 76.9% in differentiation true progression from pseudoprogression.
authors.affiliation: Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, 602 Ren Min Bei Road, Guangzhou 510180, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, 602 Ren Min Bei Road, Guangzhou 510180, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Wei
authors.affiliation: GE Healthcare China, Guangzhou, 510080, China.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, 602 Ren Min Bei Road, Guangzhou 510180, China.
authors.forename: Ruimeng
authors.initials: R
authors.lastname: Yang
authors.affiliation: Shenzhen Institutes of Advanced Technology, Shenzhen, 518055, China. Electronic address: yj.zhu@siat.ac.cn.
authors.forename: Yanjie
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Radiology, the Affiliated Guangzhou First Hospital, Guangzhou Medical University, 602 Ren Min Bei Road, Guangzhou 510180, China. Electronic address: jiangxqw@163.com.
authors.forename: Xinqing
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy*; D059248:Chemoradiotherapy; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D005909:Glioblastoma / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide
keywords: Glioblastoma; Gray level co-occurrence matric; Magnetic resonance imaging; Pseudoprogression; Texture analysis