title: Evaluation of maternal systemic inflammatory response in preeclampsia.
abstract: OBJECTIVE
  To evaluate the systemic inflammatory response in preeclampsia compared to normal pregnancy.
  
  
  METHODS
  The following serum parameters were determined in three groups of patients: leukocytes, neutrophils, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and certain markers of oxidative stress. Fetal status was assessed based on the gestational age at which birth occurred, on the Apgar score, and on fetal weight.
  
  
  RESULTS
  In preeclampsia, a higher systemic inflammatory status was found compared to normal pregnancy. Gestational age at birth, fetal weight, and Apgar score were significantly lower in the group with preeclampsia compared to normal pregnancy.
  
  
  CONCLUSIONS
  In preeclampsia, there is an increased systemic inflammatory response compared to normal pregnancy, which can influence fetal status at birth.
authors.affiliation: 2nd Department of Obstetrics and Gynecology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012, Cluj-Napoca, Romania.
authors.forename: Dan
authors.initials: D
authors.lastname: Mihu
authors.affiliation: 2nd Department of Obstetrics and Gynecology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012, Cluj-Napoca, Romania.
authors.forename: Ciortea
authors.initials: C
authors.lastname: Razvan
authors.affiliation: 2nd Department of Obstetrics and Gynecology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012, Cluj-Napoca, Romania. Electronic address: malutan.andrei@gmail.com.
authors.forename: Andrei
authors.initials: A
authors.lastname: Malutan
authors.affiliation: Department of Histology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012, Cluj-Napoca, Romania.
authors.forename: Carmen
authors.initials: C
authors.lastname: Mihaela
mesh_terms: D000328:Adult; D001034:Apgar Score; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D020567:Fetal Weight; D005865:Gestational Age; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D009504:Neutrophils / Q000378:metabolism; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011446:Prospective Studies; D012720:Severity of Illness Index; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
keywords: cytokines; inflammation; oxidative stress; preeclampsia; pregnancy