title: Hepatoprotective activity of Peganum harmala against ethanol-induced liver damages in rats.
abstract: In this study, we investigated the protective effects of Peganum harmala seeds extract (CPH) against chronic ethanol treatment. Hepatotoxicity was induced in male Wistar rats by administrating ethanol 35% (4 g/kg/day) for 6 weeks. CPH was co-administered with ethanol, by intraperitonial (IP) injection, at a dose of 10 mg/kg bw/day. Control rats were injected by saline solution (NaCl 9‰). Chronic ethanol administration intensified lipid peroxidation monitored by an increase of TBARS level in liver. Ethanol treatment caused also a drastic alteration in antioxidant defence system; hepatic superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities. A co-administration of CPH during ethanol treatment inhibited lipid peroxidation and improved antioxidants activities. However, treatment with P. harmala extract protects efficiently the hepatic function of alcoholic rats by the considerable decrease of aminotransferase contents in serum of ethanol-treated rats.
authors.affiliation: Laboratoire d'Ecophysiologie Animale, Faculté des Sciences de Sfax, University of Sfax , PB 1171 , 3000 Sfax Tunisie and.
authors.forename: Ezzeddine
authors.initials: E
authors.lastname: Bourogaa
authors.forename: Raoudha Mezghani
authors.initials: RM
authors.lastname: Jarraya
authors.forename: Mohamed
authors.initials: M
authors.lastname: Damak
authors.forename: Abdelfattah
authors.initials: A
authors.lastname: Elfeki
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006403:Hematologic Tests; D006519:Hepatitis, Alcoholic / Q000201:enzymology / Q000378:metabolism / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D032443:Peganum / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D000431:Ethanol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Antioxidant enzymes; Peganum harmala; chloroform extract; liver; seeds