title: Renal dopaminergic system: Pathophysiological implications and clinical perspectives.
abstract: Fluid homeostasis, blood pressure and redox balance in the kidney are regulated by an intricate interaction between local and systemic anti-natriuretic and natriuretic systems. Intrarenal dopamine plays a central role on this interactive network. By activating specific receptors, dopamine promotes sodium excretion and stimulates anti-oxidant and anti-inflammatory pathways. Different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome, hypertension and renal inflammation, can be associated with impaired action of renal dopamine including alteration in biosynthesis, dopamine receptor expression and signal transduction. Given its properties on the regulation of renal blood flow and sodium excretion, exogenous dopamine has been postulated as a potential therapeutic strategy to prevent renal failure in critically ill patients. The aim of this review is to update and discuss on the most recent findings about renal dopaminergic system and its role in several diseases involving the kidneys and the potential use of dopamine as a nephroprotective agent.
authors.affiliation: Marcelo Roberto Choi, Department of Anatomy and Histology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, INFIBIOC, Buenos Aires 1113, Argentina.
authors.forename: Marcelo Roberto
authors.initials: MR
authors.lastname: Choi
authors.affiliation: Marcelo Roberto Choi, Department of Anatomy and Histology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, INFIBIOC, Buenos Aires 1113, Argentina.
authors.forename: Nicolás Martín
authors.initials: NM
authors.lastname: Kouyoumdzian
authors.affiliation: Marcelo Roberto Choi, Department of Anatomy and Histology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, INFIBIOC, Buenos Aires 1113, Argentina.
authors.forename: Natalia Lucía
authors.initials: NL
authors.lastname: Rukavina Mikusic
authors.affiliation: Marcelo Roberto Choi, Department of Anatomy and Histology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, INFIBIOC, Buenos Aires 1113, Argentina.
authors.forename: María Cecilia
authors.initials: MC
authors.lastname: Kravetz
authors.affiliation: Marcelo Roberto Choi, Department of Anatomy and Histology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, INFIBIOC, Buenos Aires 1113, Argentina.
authors.forename: María Inés
authors.initials: MI
authors.lastname: Rosón
authors.affiliation: Marcelo Roberto Choi, Department of Anatomy and Histology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, INFIBIOC, Buenos Aires 1113, Argentina.
authors.forename: Martín
authors.initials: M
authors.lastname: Rodríguez Fermepin
authors.affiliation: Marcelo Roberto Choi, Department of Anatomy and Histology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, INFIBIOC, Buenos Aires 1113, Argentina.
authors.forename: Belisario Enrique
authors.initials: BE
authors.lastname: Fernández
keywords: D1 receptors; D2 receptors; Dopamine; Edema; Hypertension; Na+, K+-ATPase; Oxidative stress; Renal failure; Sodium; kidney