title: Effect of the rs1051730-rs16969968 variant and smoking cessation treatment: a meta-analysis.
abstract: OBJECTIVE
  To assess if the allelic variations of rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene cluster are associated with smoking cessation after nicotine replacement therapy (NRT).
  
  
  METHODS
  We searched for NRT studies published from 2000-2013 that reported counts for allelic variation of rs16969968/rs1051730 and measured abstinence rates at the end of NRT treatment. We identified four studies which met the criteria, giving us a test sample of 2036 participants.
  
  
  RESULTS
  There was no effect of rs16969968/rs1051730 in influencing the success rate at the end of NRT (n = 6, effect size [ES]: 0.969, 95% CI: 0.77 to 1.23, z = 0.27, p = 0.791).
  
  
  CONCLUSIONS
  There is no robust evidence that allelic variations of rs16969968 or rs1051730 are associated with smoking cessation after NRT. Original submitted 26 November 2014; Revision submitted 9 March 2015.
authors.affiliation: 1CAMH, Department of Psychiatry, University of Toronto, 250 College St, M5T1R8, Toronto, Canada.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Leung
authors.affiliation: 2SRI International, 333 Ravenswood, Menlo Park, CA 94025-3493, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Bergen
authors.affiliation: 3University of Bristol, 12a Priory Road, Bristol, BS8 1TU, UK.
authors.forename: Marcus Robert
authors.initials: MR
authors.lastname: Munafò
authors.affiliation: 1CAMH, Department of Psychiatry, University of Toronto, 250 College St, M5T1R8, Toronto, Canada.
authors.forename: Kim
authors.initials: K
authors.lastname: De Ruyck
authors.affiliation: 1CAMH, Department of Psychiatry, University of Toronto, 250 College St, M5T1R8, Toronto, Canada.
authors.forename: Peter
authors.initials: P
authors.lastname: Selby
authors.affiliation: 1CAMH, Department of Psychiatry, University of Toronto, 250 College St, M5T1R8, Toronto, Canada.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Luca
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods; D014644:Genetic Variation / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D012907:Smoking / Q000188:drug therapy* / Q000235:genetics*; D016540:Smoking Cessation / Q000379:methods; D061485:Tobacco Use Cessation Devices
keywords: CHRNA3; CHRNA5; NRT; genetics; smoking