title: Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility.
abstract: Data suggests that dopamine receptor DRD2 gene variants may contribute to hyperprolactinemia and that they may be risk factors for endometriosis-related infertility. The purpose of the present study was to determine whether nucleotide variants of the DRD2 gene may be associated with infertility related to endometriosis. Five DRD2 SNPs, rs1800497, rs6277, rs2283265, rs4245146 and rs4648317, which are located in different blocks of linkage disequilibrium, were studied in 151 cases and 381 controls. No significant differences between DRD2 rs1800497, rs6277, rs2283265, rs4245146 and rs4648317 genotype, allele nor haplotype frequencies were observed in women with endometriosis-related infertility compared with the control group. The present results did not confirm DRD2 gene variants to be genetic risk factors for endometriosis-related infertility.
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, Poznań 60‑781, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Szczepańska
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań 60‑781, Poland.
authors.forename: Adrianna
authors.initials: A
authors.lastname: Mostowska
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, Poznań 60‑781, Poland.
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Wirstlein
authors.affiliation: Department of Obstetrics, Gynecology and Gynecological Oncology, Division of Reproduction, Poznan University of Medical Sciences, Poznań 60‑781, Poland.
authors.forename: Jana
authors.initials: J
authors.lastname: Skrzypczak
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań 60‑781, Poland.
authors.forename: Matthew
authors.initials: M
authors.lastname: Misztal
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, Poznań 60‑781, Poland.
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D000328:Adult; D000483:Alleles; D004715:Endometriosis / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007246:Infertility / Q000235:genetics* / Q000473:pathology; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C581293:DRD2 protein, human; D017448:Receptors, Dopamine D2