title: Platelet-rich plasma does not decrease blood loss in total knee arthroplasty.
abstract: This study was designed to assess the use of platelet-rich plasma (PRP) during primary total knee arthroplasty (TKA). The authors hypothesized that this would result in less blood loss and greater hemoglobin and hematocrit levels at discharge and would potentially decrease the length of hospital stay. Leukocyte rich PRP was used during the procedure and at wound closure. Two surgeons performed all procedures in a similar fashion. Two different TKA implants were used. Each surgeon used the same implant throughout the study. A limited medial parapatellar approach was used and drains were used at closure. No tranexamic acid preparations were used. Continuous passive motion machines were used in all patients during their hospital stay. A total of 102 consecutive TKAs were performed. The study group (n=46) consecutively received the PRP injections during the TKA, whereas the control group (n=47) did not. Hemoglobin and hematocrit levels were obtained pre- and postoperatively. Estimated blood loss was recorded during surgery, and the auto-collection reinfusion drain system output was measured. The length of hospital stay was collected and recorded. The study showed that hemoglobin and hematocrit levels were not different when comparing study and control groups. Age and sex differences were insignificant. Finally, no statistical difference was seen for the estimated blood loss and hospital stay between the 2 groups. Platelet-rich plasma use during TKA does not decrease hospital stay or reduce estimated blood loss in the perioperative period.
authors.forename: Edwin M
authors.initials: EM
authors.lastname: Tingstad
authors.forename: Sarah N
authors.initials: SN
authors.lastname: Bratt
authors.forename: Kasee J
authors.initials: KJ
authors.lastname: Hildenbrand
authors.forename: Brittany A
authors.initials: BA
authors.lastname: O'Malley
authors.forename: Elisabeth R
authors.initials: ER
authors.lastname: Mitchell
authors.forename: Corinne E
authors.initials: CE
authors.lastname: Gaddis
authors.forename: Charles A
authors.initials: CA
authors.lastname: Jacobson
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D016022:Case-Control Studies; D004322:Drainage / Q000379:methods; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007267:Injections; D007719:Knee Joint / Q000601:surgery*; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000601:surgery*; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D006454:Hemoglobins