title: BRCA1: Beyond double-strand break repair.
abstract: Since its discovery, the BRCA1 tumor suppressor has been shown to play a role in multiple DNA damage response pathways. Here, we will review the involvement of BRCA1 in base-excision DNA repair and highlight its clinical implications.
authors.affiliation: Stanford University School of Medicine, Department of Medicine/Oncology, 269 Campus Drive, Stanford, CA 93405, USA. Electronic address: ealli@stanford.edu.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Alli
authors.affiliation: Stanford University School of Medicine, Department of Medicine/Oncology, 269 Campus Drive, Stanford, CA 93405, USA; Stanford University School of Medicine, Department of Genetics, 269 Campus Drive, Stanford, CA 93405, USA. Electronic address: jmf@stanford.edu.
authors.forename: James M
authors.initials: JM
authors.lastname: Ford
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D004249:DNA Damage; D045647:DNA Glycosylases / Q000235:genetics / Q000378:metabolism; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000737:chemistry / Q000378:metabolism*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism; D004720:Endonucleases / Q000235:genetics / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008025:Ligases / Q000235:genetics / Q000378:metabolism; D009154:Mutation
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D004273:DNA, Neoplasm; D004259:DNA-Directed DNA Polymerase; D004720:Endonucleases; D045647:DNA Glycosylases; D008025:Ligases
keywords: BRCA1; Base-excision repair