title: Alcohol abuse and alcoholic liver cirrhosis leading to spontaneous muscle hematoma: an event fraught with danger.
abstract: Alcohol abuse is associated with both potentiating and antagonizing hemostatic states. Liver cirrhosis is an independent causal factor for many bleeding complications. The long-term effects of alcohol abuse coupled with advanced liver cirrhosis are additive in favor of bleeding. We report the case of a patient with a history of alcohol abuse who presented with liver cirrhosis and nontraumatic muscle hematoma diagnosed as a spontaneous hematoma of the gastrocnemius muscle. He was managed conservatively with infusions of fresh frozen plasma and platelets, which resulted in resolution of the hematoma. The pathogenesis of 'spontaneous' muscle hematoma remains anecdotal, but since it is reported in patients on anticoagulant therapy or with hemostatic disorders, it is hypothetically related to severely deranged coagulation. Here we review the relevant literature pertaining to the pathogenesis, presentation and treatment options available for treating this often fatal complication of bleeding diatheses.
authors.affiliation: Department of Internal Medicine, Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, Ill., USA.
authors.forename: Ankit
authors.initials: A
authors.lastname: Mangla
authors.affiliation: Department of Internal Medicine, Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, Ill., USA.
authors.forename: Hussein
authors.initials: H
authors.lastname: Hamad
authors.affiliation: Department of Internal Medicine, Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, Ill., USA.
authors.forename: Udit
authors.initials: U
authors.lastname: Yadav
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, Ill., USA.
authors.forename: Margaret
authors.initials: M
authors.lastname: Telfer
keywords: Alcohol abuse; Alcoholic liver cirrhosis; Spontaneous muscle hematoma