title: Occult infection with HBV intergenotypic A2/G recombinant following acute hepatitis B caused by an HBV/A2 isolate.
abstract: Viral and host factors leading to occult hepatitis B virus (HBV) infection (OBI) are not fully understood. Whether HBV genotype may influence the occurrence and course of OBIs is unknown. Here, we describe the case of a patient infected with HBV genotype A2 who developed symptomatic acute hepatitis and did not seroconvert after loss of HBsAg and HBeAg. The acute phase of hepatitis B was followed by a period of more than 2 years during which the DNA of an intergenotypic HBV/A2/G recombinant was intermittently detected in serum.
authors.affiliation: Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil.
authors.forename: José Júnior França
authors.initials: JJ
authors.lastname: de Barros
authors.affiliation: Laboratório de Referência Nacional para Hepatites Virais, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Luciana Rego
authors.initials: LR
authors.lastname: Peres
authors.affiliation: Laboratório de Referência Nacional para Hepatites Virais, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Paulo Sérgio Fonseca
authors.initials: PS
authors.lastname: de Sousa
authors.affiliation: Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Francisco Campello
authors.initials: FC
authors.lastname: do Amaral Mello
authors.affiliation: Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Natalia Motta
authors.initials: NM
authors.lastname: de Araujo
authors.affiliation: Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Selma
authors.initials: S
authors.lastname: de Andrade Gomes
authors.affiliation: Laboratório de Virologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil. Electronic address: niel@ioc.fiocruz.br.
authors.forename: Christian
authors.initials: C
authors.lastname: Niel
authors.affiliation: Laboratório de Referência Nacional para Hepatites Virais, Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil 4365, 21045-900 Rio de Janeiro, RJ, Brazil.
authors.forename: Lia Laura
authors.initials: LL
authors.lastname: Lewis-Ximenez
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000097:blood* / Q000235:genetics; D005838:Genotype; D006509:Hepatitis B / Q000175:diagnosis / Q000473:pathology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006513:Hepatitis B e Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D011995:Recombination, Genetic
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
keywords: Brazil; Genotype A; Genotype G; HBsAg loss; Occult hepatitis B; Recombinant virus