title: Pathways of lymphatic spread in gynecologic malignancies.
abstract: Precise radiologic evaluation of regional adenopathic involvement in pelvic gynecologic tumors is fundamental to clinical practice because of its prognostic and therapeutic significance. Likewise, the identification of metastatic adenopathies at posttreatment imaging is essential for assessing response and detecting recurrence. Similar to urologic neoplasms, gynecologic neoplasms most often spread regionally to the pelvic and retroperitoneal lymph nodes, following the normal drainage pathways of the pelvic organs. Familiarity with routes of dissemination, treatment options, and means of analyzing lymph node characteristics is crucial to determine the extent of disease. Two staging systems can be used in characterizing gynecologic malignancies: the FIGO (International Federation of Gynecology and Obstetrics) system, which is the most commonly and universally used, and the TNM (tumor, node, metastasis) system, which is based on clinical and/or pathologic classification. Anatomic assessment with multidetector computed tomography (CT) and magnetic resonance (MR) imaging is still the most commonly used technique for the detection of lymph node spread, which is mainly based on morphologic criteria, the most important of which is nodal size. However, size has limited diagnostic specificity. Consequently, functional imaging techniques such as diffusion-weighted MR imaging, positron emission tomography combined with CT, lymphoscintigraphy, and sentinel lymph node mapping, which are based on molecular and physiologic activity and allow more precise evaluation, are often incorporated into diagnostic imaging protocols for staging of gynecologic malignancies.
authors.affiliation: From the CDIC, Departments of Radiology (B.P., C.S., E.R., R.S., L.B., C.N.) and Nuclear Medicine (P.P.), Hospital Clínic de Barcelona, Villarroel 170, 08036 Barcelona, Spain.
authors.forename: Blanca
authors.initials: B
authors.lastname: Paño
authors.forename: Carmen
authors.initials: C
authors.lastname: Sebastià
authors.forename: Enric
authors.initials: E
authors.lastname: Ripoll
authors.forename: Pilar
authors.initials: P
authors.lastname: Paredes
authors.forename: Rafael
authors.initials: R
authors.lastname: Salvador
authors.forename: Laura
authors.initials: L
authors.lastname: Buñesch
authors.forename: Carlos
authors.initials: C
authors.lastname: Nicolau
mesh_terms: D003952:Diagnostic Imaging; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D021701:Sentinel Lymph Node Biopsy