title: [Application of Chimeric Antigen Receptor-Modified CAR-T/NK Cells to Treatment of Multiple Myeloma].
abstract: Chimeric antigen receptor(CAR) is a synthesized transmembrane protein, which redirects the modified cells through specific or associated antigen on tumor cells. CAR-modified T/NK cells, especially CAR-T cells, are a new tool of rapidly developing of adoptive immunotherapy of tumor in recent years, they give T/NK cells the targeting cytotoxic activity and can overcome the tumor immunosuppressive microenvironment and break the state of the host immune tolerance. CAR combines the single-chain antibody to tumor-associated antigen with T/NK cells' activated motifs, giving T/NK cells' tumor targeting activity, so enhancing their cytotoxic activity and lasting the vitality by gene transduction. In this article the CAR development, comparison of CAR-T and CAR-NK cells, surface markers on MM cells and use of CAR in MM, and CAR perspectives are summarized.
authors.affiliation: Department of Hematology, The second Clinical Medical College, Lanzhou University, Lanzhou 730050, Gansu Province, China.|Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
authors.forename: jian-Feng
authors.initials: jF
authors.lastname: Ou
authors.affiliation: Department of Hematology, Center of Hematologic Diseases of Chinese PLA; Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China. E-mail: baihai98@tom.com.
authors.forename: Hai
authors.initials: H
authors.lastname: Bai
mesh_terms: D000951:Antigens, Neoplasm; D045744:Cell Line, Tumor; D006801:Humans; D016219:Immunotherapy, Adoptive; D007694:Killer Cells, Natural; D008213:Lymphocyte Activation; D009101:Multiple Myeloma; D011946:Receptors, Antigen; D013601:T-Lymphocytes
chemical_list: D000951:Antigens, Neoplasm; D011946:Receptors, Antigen