title: Impact of postoperative chemotherapy in patients with locally advanced gastroesophageal adenocarcinoma treated with perioperative chemotherapy strategy.
abstract: BACKGROUND
  The aim of this study was to determine the clinical impact of postoperative chemotherapy (POC) in patients with locally advanced gastroesophageal adenocarcinoma and determine the predictors of delivery of planned POC.
  
  
  METHODS
  All consecutive patients with locally advanced gastroesophageal adenocarcinoma treated by perioperative chemotherapy (PCT) at our center were selected. Overall survival and disease-free survival were compared in patients who did not undergo planned POC (nondelivery of nPOC group) and patients who underwent POC (POC group).
  
  
  RESULTS
  Among 385 patients who underwent esophagectomies or gastrectomies, PCT was performed in 110 patients. Of these, 74 (67%) patients underwent POC. Predictors of overall survival included postoperative morbidity, pT3-4 stage, R1 resection, and delivery of more than 1 cycle of POC. Factors predicting POC application included postoperative morbidity, esophagectomy, and body mass index.
  
  
  CONCLUSIONS
  Two cycles of POC were necessary to improve survival in patients with gastroesophageal adenocarcinoma.
authors.affiliation: Department of Digestive Surgery, University Hospital of Bordeaux, Maison du Haut-Lévêque, Bordeaux, France. Electronic address: guillaume.luc@chu-bordeaux.fr.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Luc
authors.affiliation: Department of Digestive Surgery, University Hospital of Bordeaux, Maison du Haut-Lévêque, Bordeaux, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Gersen-Cherdieu
authors.affiliation: Department of Digestive Surgery, University Hospital of Bordeaux, Maison du Haut-Lévêque, Bordeaux, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Degrandi
authors.affiliation: Department of Digestive Oncology, University Hospital of Bordeaux, USN, Bordeaux, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Terrebonne
authors.affiliation: Department of Digestive Surgery, University Hospital of Bordeaux, Maison du Haut-Lévêque, Bordeaux, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Chiche
authors.affiliation: Department of Digestive Surgery, University Hospital of Bordeaux, Maison du Haut-Lévêque, Bordeaux, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Collet
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D016629:Esophagectomy; D004943:Esophagogastric Junction; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011182:Postoperative Care; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D055815:Young Adult
keywords: Gastroesophageal adenocarcinoma; Perioperative chemotherapy; Postoperative chemotherapy