title: Papanicolaou smears of atypical glandular cells of undetermined significance: histological correlations and suggestions for management.
abstract: OBJECTIVE
  We sought to correlate cervical and endometrial neoplasias with Papanicolaou (Pap) smears of atypical glandular cells of undetermined significance (AGUS) and to suggest management.
  
  
  METHODS
  One hundred seventy-one patients with AGUS Pap smears were followed prospectively with colposcopy, biopsies, endocervical curettage, and endometrial biopsies.
  
  
  RESULTS
  One hundred twelve patients (65%) with AGUS Pap smears favoring reactive changes were found to harbor 13 preinvasive and invasive cervical squamous neoplasias and 1 ovarian sarcoma (total, 12.5% of patients with smears). Fifty-nine patients (35%) with AGUS Pap smears favoring neoplastic changes harbored 25 preinvasive and invasive squamous and glandular cervical and endometrial neoplasias (42.3%).
  
  
  CONCLUSIONS
  In the presence of an AGUS Pap smear favoring reactive changes, colposcopy, biopsies, and endocervical curettage should be performed. Endometrial biopsy should be added when AGUS Pap smear favors neoplasia.
authors.affiliation: *Departments of Obstetrics and Gynecology, University of Texas Medical Branch at Galveston, TX †Departments of Pathology, University of Texas Medical Branch at Galveston, TX.
authors.forename: T V
authors.initials: TV
authors.lastname: Dinh
authors.forename: M
authors.initials: M
authors.lastname: Haque
authors.forename: J M
authors.initials: JM
authors.lastname: Gracia
authors.forename: J A
authors.initials: JA
authors.lastname: Lucci
authors.forename: E R
authors.initials: ER
authors.lastname: Smith
authors.forename: E V
authors.initials: EV
authors.lastname: Hannigan