title: New-onset diabetes and glucose regulation are significant determinants of left ventricular hypertrophy in renal transplant recipients.
abstract: BACKGROUND
  New-onset diabetes after transplantation (NODAT) is associated with decreased graft survival and an increased risk for cardiovascular disease. The objective of this study was to evaluate the risk factors for development of NODAT and its' relationship with arterial stiffness and left ventricular mass index (LVMI) in kidney transplant recipients.
  
  
  METHODS
  159 kidney transplant recipients were selected from our transplantation center who underwent renal transplantation between years 2007 and 2010.
  
  
  RESULTS
  Among 159 patients, 57 (32.2%) patients were with NODAT who were significantly older than patients without diabetes (P: 0.0001). Patients with NODAT had significantly higher pulse wave velocity (PWv) (P: 0.033) and left ventricular mass index LVMI (P: 0.001) compared to patients without NODAT. Further analysis was done according to LVMI as follows: LVMI > 130 g/m(2) (n: 57) and LVMI ≤ 130 g/m(2) (n: 102). We observed higher office systolic and diastolic BP, serum trygliceride, glucose, creatinine, age, and HbA1c (P: 0.0001) levels in patients with LVMI > 130 g/m(2). Linear regression analysis revealed that HbA1c was the major determinant of LVMI (P: 0.026, β: 0.361).
  
  
  CONCLUSIONS
  HbA1c is the major determinant of LVMI, so strict control of serum glucose levels is essential for preventing cardiovascular disease in patients with NODAT.
authors.affiliation: Department of Nephrology, Baskent University Medical School, 06490 Ankara, Turkey.
authors.forename: Siren
authors.identifier: 0000-0002-7326-8388
authors.initials: S
authors.lastname: Sezer
authors.affiliation: Department of Nephrology, Baskent University Medical School, 06490 Ankara, Turkey.
authors.forename: Mehtap
authors.initials: M
authors.lastname: Erkmen Uyar
authors.affiliation: Department of Nephrology, Baskent University Medical School, 06490 Ankara, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Tutal
authors.affiliation: Department of Nephrology, Baskent University Medical School, 06490 Ankara, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Bal
authors.affiliation: Department of Nephrology, Baskent University Medical School, 06490 Ankara, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Guliyev
authors.affiliation: Department of Nephrology, Baskent University Medical School, 06490 Ankara, Turkey.
authors.forename: Turan
authors.initials: T
authors.lastname: Colak
authors.affiliation: Department of Internal Medicine, Baskent University Medical School, 06490 Ankara, Turkey.
authors.forename: Efe
authors.initials: E
authors.lastname: Hasdemir
authors.affiliation: Department of Transplantation Surgery, Baskent University Medical School, 06490 Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Haberal
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000502:physiology; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D059289:Vascular Stiffness / Q000502:physiology
chemical_list: D001786:Blood Glucose