title: Intraoperative Blood Loss During Orthognathic Surgery: A Comparison of Remifentanil-Based Anesthesia With Sevoflurane or Isoflurane.
abstract: OBJECTIVE
  The aim of the present study was to compare the blood loss with remifentanil-based anesthesia with sevoflurane or isoflurane during orthognathic surgery.
  
  
  METHODS
  In this randomized controlled clinical trial, the patients who were scheduled for orthognathic surgery were divided into 2 groups: the sevoflurane (Sevo) group and isoflurane (Iso) group. Anesthesia was maintained using end-tidal concentrations of 1.4% sevoflurane or 0.9% isoflurane. Remifentanil was continuously infused at 0.05 to 0.5 μg/kg/min to maintain the mean blood pressure (MBP) at 60 to 65 mm Hg. The intraoperative blood loss was compared between the 2 groups. The Student t test for unpaired samples was used for statistical analysis. P < .05 was considered statistically significant.
  
  
  RESULTS
  The study sample included 19 men and 45 women (n = 64). The mean age was 25 years (range 16 to 50). The intraoperative blood loss tended to be greater in the Iso group (n = 32; 4.79 ± 3.22 mL/kg) than in the Sevo group (n = 32; 4.00 ± 1.98 mL/kg). However, the difference between the 2 groups was not significant.
  
  
  CONCLUSIONS
  In a comparison of intraoperative blood loss during remifentanil-based anesthesia with sevoflurane or isoflurane during orthognathic surgery, no difference was observed between the 2 groups.
authors.affiliation: Postgraduate Student, Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan. Electronic address: wakasugiyumiko@tdc.ac.jp.
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Wakasugi
authors.affiliation: Senior Assistant Professor, Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Matsuura
authors.affiliation: Professor and Chairman, Department of Dental Anesthesiology, Tokyo Dental College, Chiba, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ichinohe
mesh_terms: D000293:Adolescent; D000328:Adult; D000766:Anesthesia, Dental / Q000009:adverse effects* / Q000379:methods; D019162:Anesthetics, Combined / Q000008:administration & dosage / Q000009:adverse effects*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D016063:Blood Loss, Surgical / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D056948:Orthognathic Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D010880:Piperidines / Q000008:administration & dosage / Q000009:adverse effects*; D000077208:Remifentanil; D000077149:Sevoflurane; D055815:Young Adult
chemical_list: D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D010880:Piperidines; D000077149:Sevoflurane; D007530:Isoflurane; D000077208:Remifentanil