title: Carbohydrate antigen 125 levels and clinical outcomes after off-pump coronary artery bypass grafting.
abstract: OBJECTIVE
  The present study aimed to evaluate the prognostic value of preoperative carbohydrate antigen 125 (CA125) levels for clinical outcomes after off-pump coronary artery bypass grafting (OPCAB).
  
  
  METHODS
  A total of 314 consecutive patients who underwent OPCAB were enrolled in this study and divided into three groups corresponding to baseline CA125 level tertiles. Clinical outcomes of these patients were followed up after 1 year. The primary endpoint was the incidence of combined major adverse cardiac events (MACE).
  
  
  RESULTS
  Event-free survival was significantly associated with the CA125 tertile (log-rank P=0.021); specifically, hazard ratios (HRs) increased progressively from CA125 tertile 1 to tertile 3 [vs. tertile 1: tertile 2 h=1.8; 95% confidence interval (CI): 1.1-2.8, P=0.040; tertile 3 h=2.9; 95% CI: 1.1-8.1, P=0.018]. In the first multivariate Cox regression analytical model (all variables except EuroSCORE), CA125 was an independent predictor of MACE (HR=1.1, 95% CI: 1.0-2.4, P=0.016). In a second model (CA125 levels and EuroSCORE only), CA125 remained an independent predictor of MACE (HR=1.1, 95% CI: 1.0-1.3, P=0.036).
  
  
  CONCLUSIONS
  An increased preoperative CA125 level is an independent predictor of worse clinical outcomes after OPCAB during a 1-year follow-up.
authors.affiliation: Departments of aCardiac Surgery bCardiology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Song
authors.forename: Fu-Lin
authors.initials: FL
authors.lastname: Liu
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Lou
authors.forename: Zhe
authors.initials: Z
authors.lastname: Han
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Zhou
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhou
authors.forename: Ke-Ye
authors.initials: KY
authors.lastname: Liu
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D016009:Chi-Square Distribution; D002681:China; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects / Q000401:mortality; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D052279:Creatine Kinase, MB Form / Q000097:blood; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000209:etiology; D016016:Proportional Hazards Models; D012307:Risk Factors; D020521:Stroke / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins; D019210:Troponin I; D052279:Creatine Kinase, MB Form