title: CYP2E1 Rsa Ι/Pst Ι polymorphism and lung cancer susceptibility: a meta-analysis involving 10,947 subjects.
abstract: Many studies have examined the association between the CYP2E1 Rsa Ι/Pst Ι (rs3813867) polymorphism gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent. The PubMed and CNKI database was searched for case-control studies published up to October 2013. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. In this meta-analysis, we assessed 23 published studies involving comprising 4727 lung cancer cases and 6220 controls of the association between CYP2E1 Rsa Ι/Pst Ι polymorphism and lung cancer risk. For the homozygote c2/c2 and c2 allele carriers (c1/c2 + c2/c2), the pooled ORs for all studies were 0.73(95% CI = 0.62-0.84; P = 0.005 for heterogeneity) and 0.84 (95% CI = 0.77-0.92; P = 0.001 for heterogeneity) when compared with the homozygous wild-type genotype (c1/c1). In the stratified analysis by ethnicity, the same significantly risks were found among Asians and mixed population for both the c2 allele carriers and homozygote c2/c2. However, no significant associations were found in Caucasian population all genetic models. This updated meta-analysis suggests that CYP2E1 Rsa Ι/Pst Ι c2 allele is a decreased risk factor for the developing lung cancer among Asians and mixed population.
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Ze-Tian
authors.initials: ZT
authors.lastname: Shen
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Xin-Hu
authors.initials: XH
authors.lastname: Wu
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Jun-shu
authors.initials: JS
authors.lastname: Shen
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Xi-Xu
authors.initials: XX
authors.lastname: Zhu
mesh_terms: D000483:Alleles; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D019392:Cytochrome P-450 CYP2E1
keywords: CYP2E1; lung cancer; meta-analysis; polymorphism; susceptibility