title: The Transition From Postexposure Prophylaxis to Preexposure Prophylaxis: An Emerging Opportunity for Biobehavioral HIV Prevention.
abstract: Although some individuals who present for antiretroviral postexposure prophylaxis (PEP) had a 1-time exposure to human immunodeficiency virus (HIV), others may be recurrently risky. Given that preexposure prophylaxis (PrEP) has been shown to be efficacious, identification of those individuals who present for PEP who might benefit from PrEP is important to decrease HIV acquisition in high-risk individuals. While inclusion criteria for PrEP have been developed, there is a paucity of data to help clinicians determine which PEP users are at highest risk for HIV acquisition and therefore should be offered PrEP. We will discuss the rationale for using PrEP after PEP use, and will focus on the assessment of PEP users who may benefit from PrEP.
authors.affiliation: Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
authors.forename: Sachin
authors.initials: S
authors.lastname: Jain
authors.affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School The Fenway Institute, Fenway Health, Boston, Massachusetts.
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Krakower
authors.affiliation: Beth Israel Deaconess Medical Center, Harvard Medical School The Fenway Institute, Fenway Health, Boston, Massachusetts.
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Mayer
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015658:HIV Infections / Q000517:prevention & control* / Q000523:psychology / Q000635:transmission; D006801:Humans; D056990:Post-Exposure Prophylaxis; D065129:Pre-Exposure Prophylaxis; D040242:Risk Reduction Behavior
chemical_list: D019380:Anti-HIV Agents
keywords: HIV prevention; postexposure prophylaxis; preexposure prophylaxis