title: Geranylated flavanones from Paulownia coreana and their inhibitory effects on nitric oxide production.
abstract: The activity-guided fractionation of the MeOH extract of the flower of Paulownia coreana led to the isolation of a new geranylated flavanone, 3'-O-methyl-5'-hydroxydiplacol (1), along with 10 known compounds (2-11). Their structures were determined using spectroscopic techniques, which included one and two dimensional (1- and 2D)-NMR. Among the isolates, compounds 1-6 showed potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production with IC50 values ranging 1.48 to 16.66 µM.
authors.affiliation: College of Pharmacy, Chungbuk National University.
authors.forename: Qinghao
authors.initials: Q
authors.lastname: Jin
authors.forename: Chul
authors.initials: C
authors.lastname: Lee
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Kim
authors.forename: Joo-Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
mesh_terms: D000818:Animals; D002460:Cell Line; D044950:Flavanones / Q000737:chemistry* / Q000494:pharmacology*; D035264:Flowers / Q000737:chemistry; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D010944:Plants / Q000737:chemistry*
chemical_list: D044950:Flavanones; D009569:Nitric Oxide