title: Idiopathic Peripapillary Subretinal Neovascular Membrane in a Young Woman with Recurrence of the Lesion during Pregnancy after Treatment with Intravitreal Bevacizumab.
abstract: We report a 27-year-old woman who was diagnosed with idiopathic peripapillary subretinal neovascular membrane (PSRNVM) in her left eye with best-corrected visual acuity (BCVA) of 20/160. She had been treated by three monthly doses of intravitreal bevacizumab (1.25 mg/0.05 ml) at 4-week intervals, which showed a favorable response. The treatment led to regression of the choroidal neovascular membrane (CNVM) with complete resorption of subretinal fluid and improvement of BCVA to 20/25. Subsequently, recurrence of the CNVM was observed during pregnancy (28 months after treatment). To the best of our knowledge, this is the first report of recurrence of idiopathic PSRNVM during pregnancy.
authors.affiliation: Division of Vitreoretinal, Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia.
authors.forename: Nasra
authors.initials: N
authors.lastname: Al-Gharbi
authors.affiliation: Depatment of Ophthalmology, King Abdulaziz Hospital, Al Ahsa, National Guard Health Affairs, Saudi Arabia.
authors.forename: Omar
authors.initials: O
authors.lastname: Al Abdulsalam
authors.affiliation: Department of Ophthalmology, University of Dammam, Dammam, Saudi Arabia.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al Habash
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000068258:Bevacizumab; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000188:drug therapy*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D058449:Intravitreal Injections; D009898:Optic Disk; D011247:Pregnancy; D011248:Pregnancy Complications; D012008:Recurrence; D058471:Subretinal Fluid; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity / Q000502:physiology
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab
keywords: Anti-Vascular Endothelial Growth Factor; Choroidal Neovascular Membrane; Idiopathic Peripapillary Subretinal Neovascular Membrane; Intravitreal Bevacizumab; Pregnancy