title: Postprandial Dysmetabolism and Oxidative Stress in Type 2 Diabetes: Pathogenetic Mechanisms and Therapeutic Strategies.
abstract: Postprandial dysmetabolism in type 2 diabetes (T2D) is known to impact the progression and evolution of this complex disease process. However, the underlying pathogenetic mechanisms still require full elucidation to provide guidance for disease prevention and treatment. This review focuses on the marked redox changes and inflammatory stimuli provoked by the spike in blood glucose and lipids in T2D individuals after meals. All the causes of exacerbated postprandial oxidative stress in T2D were analyzed, also considering the consequence of enhanced inflammation on vascular damage. Based on this in-depth analysis, current strategies of prevention and pharmacologic management of T2D were critically reexamined with particular emphasis on their potential redox-related rationale.
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin, 10043, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Sottero
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin, 10043, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Gargiulo
authors.affiliation: Internal Medicine and Metabolic Disease Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin, 10043, Italy.
authors.forename: Isabella
authors.initials: I
authors.lastname: Russo
authors.affiliation: Internal Medicine and Metabolic Disease Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin, 10043, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Barale
authors.affiliation: Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin, 10043, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Poli
authors.affiliation: Internal Medicine and Metabolic Disease Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano, Turin, 10043, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Cavalot
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000737:chemistry; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000503:physiopathology*; D004032:Diet; D038441:Diet, Mediterranean; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D015444:Exercise; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000473:pathology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007249:Inflammation; D008019:Life Style; D008055:Lipids / Q000737:chemistry; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010100:Oxygen / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry; D019518:Postprandial Period
chemical_list: D000447:Aldehydes; D000975:Antioxidants; D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D017127:Glycation End Products, Advanced; D007004:Hypoglycemic Agents; D008055:Lipids; D016877:Oxidants; D010743:Phospholipids; D002784:Cholesterol; D010100:Oxygen
keywords: oxidative stress; postprandial dysmetabolism; redox signaling; redox-oriented therapy; type 2 diabetes