title: Molecular epidemiology of severe respiratory disease by human rhinoviruses and enteroviruses at a tertiary paediatric hospital in Barcelona, Spain.
abstract: In order to describe the molecular epidemiology of human rhinovirus (HRV) and enterovirus (EV) infection in severely ill children, we studied all episodes of bronchospasm/bronchopneumonia in 6-month-old to 18-year-old patients from January 2010 to May 2012 who required mechanical ventilation. HRV/EVs were detected in 55 (57.3%) of 96 patients, of which 50 (91%) were HRV (HRV-A, 16; HRV-B, 1; HRV-C, 18) and 5 (9%) were EVs (EV-D68, 3). No significant differences in epidemiologic and clinical characteristics were found between different types. In six of the 13 patients who required invasive mechanical ventilation, HRV was the only pathogen detected.
authors.affiliation: Infectious Diseases Research Unit, Department of Paediatrics, Barcelona, Spain. Electronic address: claunes@hsjdbcn.org.
authors.forename: C
authors.initials: C
authors.lastname: Launes
authors.affiliation: Paediatric Intensive Care Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Armero
authors.affiliation: Respiratory Viruses Unit, Department of Microbiology, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Anton
authors.affiliation: Paediatric Intensive Care Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Hernandez
authors.affiliation: Respiratory Viruses Unit, Department of Microbiology, Hospital Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Gimferrer
authors.affiliation: Infectious Diseases Research Unit, Department of Molecular Microbiology, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Cisneros
authors.affiliation: Paediatric Intensive Care Unit, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Jordan
authors.affiliation: Infectious Diseases Research Unit, Department of Molecular Microbiology, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Muñoz-Almagro
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004770:Enterovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D017720:Molecular Epidemiology; D010850:Picornaviridae Infections / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy / Q000821:virology; D015995:Prevalence; D011446:Prospective Studies; D012121:Respiration, Artificial; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy / Q000821:virology; D012229:Rhinovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D013030:Spain / Q000453:epidemiology; D062606:Tertiary Care Centers
keywords: Enterovirus; molecular epidemiology; paediatric intensive care; respiratory viruses; rhinovirus; types