title: Sesquiterpenes from the fruits of Illicium jiadifengpi and their anti-hepatitis B virus activities.
abstract: Two new compounds, 2S-hydroxyl-jiadifenolide (1) and jiadifenlactone acid (2), and eight known compounds were isolated from the fruits of Illicium jiadifengpi. Their structures were analysed using several spectroscopic techniques, including 1D-, 2D-NMR and HR-ESI-MS experiments. The anti-hepatitis B virus (HBV) activities of the isolates were evaluated via HBV transfection of the Hep G2.2.15 cell line. The inhibitory rates of the most active compounds, compounds 4 and 5, on the HBeAg and HBsAg expression were 28.85±3.15% and 17.53±1.81% and 37.93±2.74% and 23.47±9.52% at concentrations of 64.94μM and 61.35μM, respectively.
authors.affiliation: School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, People's Republic of China. Electronic address: Liujf2009y@126.com.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Liu
authors.affiliation: College of Chemistry and Chemical Engineering, Xuchang University, Henan, Xuchang 461000, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, People's Republic of China; Henan Key laboratory for Pharmacology of Liver Disease, Academy of Medical and Pharmaceutical Science, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, People's Republic of China.
authors.forename: Ya-Feng
authors.initials: YF
authors.lastname: Wang
authors.affiliation: School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, People's Republic of China.
authors.forename: Xu
authors.initials: X
authors.lastname: Song
authors.affiliation: School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, People's Republic of China.
authors.forename: Li-Jia
authors.initials: LJ
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, People's Republic of China. Electronic address: Zhangyb@zzu.edu.cn.
authors.forename: Yan-Bing
authors.initials: YB
authors.lastname: Zhang
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D056945:Hep G2 Cells; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D029523:Illicium / Q000737:chemistry*; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D012717:Sesquiterpenes; C000601747:jiadifenlactone acid; C546282:jiadifenolide
keywords: Anti-HBV activity; Illiciaceae; Illicium jiadifengpi; Sesquiterpenes