title: Should pharmacotherapy of digoxin be reviewed in male patients with heart failure in the case of association with carvedilol?
authors.affiliation: Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
authors.forename: Felipe C
authors.initials: FC
authors.lastname: Souza
authors.affiliation: Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
authors.forename: Jéssica S
authors.initials: JS
authors.lastname: Neri
authors.affiliation: Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
authors.forename: Emiliana B
authors.initials: EB
authors.lastname: Marques
authors.affiliation: Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
authors.forename: Rogério B M
authors.initials: RB
authors.lastname: Barros
authors.affiliation: Laboratory of Experimental Pharmacology, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil. Electronic address: christiannebretas@vm.uff.br.
authors.forename: Christianne B V
authors.initials: CB
authors.lastname: Scaramello
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000097:blood; D000328:Adult; D000368:Aged; D001682:Biological Availability; D002227:Carbazoles / Q000008:administration & dosage* / Q000097:blood; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics*; D000077261:Carvedilol; D002986:Clinical Trials as Topic; D018592:Cross-Over Studies; D004077:Digoxin / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000008:administration & dosage* / Q000097:blood
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D002316:Cardiotonic Agents; D011412:Propanolamines; D000077261:Carvedilol; D004077:Digoxin
keywords: Carvedilol; Digoxin; Drug interactions; P-glycoprotein; Pharmacokinetics; Toxicity