title: Hydroquinone-assisted synthesis of branched au-ag nanoparticles with polydopamine coating as highly efficient photothermal agents.
abstract: Despite the success of galvanic replacement in preparing hollow nanostructures with diversified morphologies via the replacement reaction between sacrificial metal nanoparticles (NPs) seeds and less active metal ions, limited advances are made for producing branched alloy nanostructures. In this paper, we report an extended galvanic replacement for preparing branched Au-Ag NPs with Au-rich core and Ag branches using hydroquinone (HQ) as the reductant. In the presence of HQ, the preformed Ag seeds are replaceable by Au and, in turn, supply the growth of Ag branches. By altering the feed ratio of Ag seeds, HAuCl4, and HQ, the size and morphology of the NPs are tunable. Accordingly, the surface plasmon resonance absorption is tuned to near-infrared (NIR) region, making the branched NPs as potential materials in photothermal therapy. The branched NPs are further coated with polydopamine (PDA) shell via dopamine polymerization at room temperature. In comparison with bare NPs, PDA-coated branched Au-Ag (Au-Ag@PDA) NPs exhibit improved stability, biocompatibility, and photothermal performance. In vitro experiments indicate that the branched Au-Ag@PDA NPs are competitive agents for photothermal ablation of cancer cells.
authors.affiliation: †State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: †State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Wang
authors.affiliation: ‡School of Stomatology, Jilin University, Changchun 130041, People's Republic of China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhao
authors.affiliation: §First Hospital of Jilin University, Changchun 130021, People's Republic of China.
authors.forename: Li
authors.initials: L
authors.lastname: Rong
authors.affiliation: §First Hospital of Jilin University, Changchun 130021, People's Republic of China.
authors.forename: Shijie
authors.initials: S
authors.lastname: Lan
authors.affiliation: ‡School of Stomatology, Jilin University, Changchun 130041, People's Republic of China.
authors.forename: Hongchen
authors.initials: H
authors.lastname: Sun
authors.affiliation: †State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: †State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China.
authors.forename: Bai
authors.initials: B
authors.lastname: Yang
mesh_terms: D002470:Cell Survival / Q000187:drug effects*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis*; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D006873:Hydroquinones / Q000737:chemistry*; D007211:Indoles; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000648:ultrastructure; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry; D011108:Polymers; D012834:Silver / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D020099:Coated Materials, Biocompatible; D006873:Hydroquinones; D007211:Indoles; D053769:Nanocapsules; D017319:Photosensitizing Agents; D011108:Polymers; C568283:polydopamine; D012834:Silver; D006046:Gold; C031927:hydroquinone
keywords: hydroquinone; metal nanostructures; nanocomposites; photothermal therapy; polydopamine