title: Expression of Formyl-peptide Receptors in Human Lung Carcinoma.
abstract: OBJECTIVE
  Formyl-peptide receptors (FPRs) are expressed in several tissues and cell types. The identification of markers involved in cell growth may further allow for molecular profiling of lung cancer. We investigated the possible role of FPRs as molecular markers in several types of lung carcinomas which is the main cause of cancer death worldwide.
  
  
  METHODS
  Tumor tissue samples were collected from six patients affected by lung cancer. Biopsies were analyzed for expression of FPR isoforms both in tumoral and peritumoral tissue by real-time polymerase chain reaction (PCR), western blot and immunofluorescence.
  
  
  RESULTS
  Real-time PCR, western blot and immunofluorescence analyses showed that FPR expression is lower in types of human lung cancer tissues when compared to the surrounding peritumoral tissues.
  
  
  CONCLUSIONS
  The study of the mechanistic basis for the control of FPR expression in normal peritumoral versus tumoral tissues could provide the basis for new diagnostic and therapeutic interventions.
authors.affiliation: Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, Naples, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Cattaneo
authors.affiliation: Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy.
authors.forename: Germano
authors.initials: G
authors.lastname: Guerra
authors.affiliation: Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, Naples, Italy.
authors.forename: Melania
authors.initials: M
authors.lastname: Parisi
authors.affiliation: Section of Human Anatomy, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Lucariello
authors.affiliation: Section of Human Anatomy, Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Naples, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: De Luca
authors.affiliation: Department of Cardiothoracic and Respiratory Sciences, Monaldi Hospital, Second University of Naples, Naples, Italy.
authors.forename: Nicolina
authors.initials: N
authors.lastname: De Rosa
authors.affiliation: Department of Cardiothoracic and Respiratory Sciences, Monaldi Hospital, Second University of Naples, Naples, Italy.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Mazzarella
authors.affiliation: Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso, Italy rosario.ammendola@unina.it andrea.bianco@unimol.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bianco
authors.affiliation: Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, Naples, Italy rosario.ammendola@unina.it andrea.bianco@unimol.it.
authors.forename: Rosario
authors.initials: R
authors.lastname: Ammendola
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D045744:Cell Line, Tumor; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D020033:Protein Isoforms / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D044042:Receptors, Formyl Peptide / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D020033:Protein Isoforms; D012333:RNA, Messenger; D044042:Receptors, Formyl Peptide
keywords: Formyl-peptide receptors; gene expression; lung cancer