title: Changing Grains for the Prevention and Treatment of Kashin-Beck Disease in Children: a Meta-analysis.
abstract: To evaluate the efficacy of changing grains on the prevention and treatment of Kashin-Beck Disease (KBD) in children, community-based trials were acquired from seven electronic databases (up to July 2014). As a result, the methodological quality of the six trials that have been included into our analysis was low. The pooled ORs favoring the prevention and treatment effects of changing grains were 0.15 (95% CI: 0.03-0.70) and 2.13 (95% CI: 1.44-3.16) respectively by meta-analysis. Subgroup analysis demonstrated the pooled OR favoring treatment effect of exchanging grains rather than drying grains both compared with endemic grains. The results showed that changing grains had obvious effects on the prevention and treatment of KBD in children. However, the evidences were limited by the potential biases and confounders. Large and well-designed trials are still needed.
authors.affiliation: College of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.affiliation: College of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Fang Fang
authors.initials: FF
authors.lastname: Yu
authors.affiliation: Department of Surgery, The Second Hospital of Weinan City, Weinan 714000, Shaanxi, China.
authors.forename: Zai Ping
authors.initials: ZP
authors.lastname: Chang
authors.affiliation: Department of Laboratory Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Applied Physics, University of Eastern Finland, Kuopio 70211, Finland.
authors.forename: Cheng Juan
authors.initials: CJ
authors.lastname: Qu
authors.affiliation: College of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Tian Tian
authors.initials: TT
authors.lastname: Zhou
authors.affiliation: Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Rui Yu
authors.initials: RY
authors.lastname: Liu
authors.affiliation: College of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D055812:Community-Based Participatory Research; D002523:Edible Grain / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D057767:Kashin-Beck Disease / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*