title: Metal complexes of curcumin--synthetic strategies, structures and medicinal applications.
abstract: This Tutorial Review presents an overview on the synthesis, characterization and applications of metal complexes containing curcumin (=1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) and its derivatives as ligands. Innovative synthetic strategies leading to soluble and crystallizable metal curcumin complexes are outlined in detail. Special emphasis is placed on the highly promising and exciting medicinal applications of metal curcumin complexes, with the three most important areas being anticancer activity and selective cytotoxicity, anti-Alzheimer's disease activity, and antioxidative/neuroprotective effects. Overall, this Tutorial Review provides the first general overview of this emerging and rapidly expanding field of interdisciplinary research.
authors.affiliation: Chemisches Institut der Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany. frank.edelmann@ovgu.de.
authors.forename: Simon
authors.initials: S
authors.lastname: Wanninger
authors.forename: Volker
authors.initials: V
authors.lastname: Lorenz
authors.forename: Abdus
authors.initials: A
authors.lastname: Subhan
authors.forename: Frank T
authors.initials: FT
authors.lastname: Edelmann
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D000975:Antioxidants; D045744:Cell Line, Tumor; D056831:Coordination Complexes; D003474:Curcumin; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D056831:Coordination Complexes; D003474:Curcumin