title: [Leucoderma in children: Review of the literature].
abstract: BACKGROUND
  Leucoderma is a frequent presenting complaint in children and it is sometimes difficult to make a definite diagnostic during the first consultation. The aim of this study is to analyse the diagnoses associated with leucoderma in children in order to propose a practical approach to their differential diagnosis.
  
  
  METHODS
  We performed a review of the literature using the keywords "leucoderma children review", "leucoderma Ito" and "nevus depigmentosus" in the Medline database. All relevant articles were included.
  
  
  RESULTS
  Four hundred and thirty-five articles were retrieved and 179 were analysed. A clinical approach was proposed in 6 articles and investigations in 15 articles.
  
  
  CONCLUSIONS
  Causal diagnosis of leucoderma may frequently be made on clinical grounds by determining the age of onset and distribution of lesions. Nevertheless, some situations require investigation. The literature is limited regarding clinical approaches and examinations in leucoderma. Herein, we present a systematic clinical and laboratory approach to the differential diagnosis of these skin disorders.
authors.affiliation: Clinique dermatologique de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Moulinas
authors.affiliation: Service de génétique médicale, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Dollfus
authors.affiliation: Clinique dermatologique de Strasbourg, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg cedex, France. Electronic address: dan.lipsker@chru-strasbourg.fr.
authors.forename: D
authors.initials: D
authors.lastname: Lipsker
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D000293:Adolescent; D017668:Age of Onset; D000417:Albinism / Q000453:epidemiology / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D017496:Hypopigmentation / Q000145:classification / Q000151:congenital / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000235:genetics; D009154:Mutation; D017384:Sequence Deletion; D063189:Symptom Assessment; D013577:Syndrome
keywords: Children; Enfant; Genodermatoses; Génodermatose; Hypopigmentation; Leucoderma; Leucodermie