title: Expression of focal adhesion kinase in endometrial stromal cells of women with endometriosis was adjusted by ovarian steroid hormones.
abstract: The aim of our study is to investigate the effects of ovarian steroid hormones on focal adhesion kinase (FAK) expression in ESCs and whether there is alteration in women with endometriosis. FAK expression was assessed by western blotting analysis. Elevated expression of FAK was seen in the cultured ESCs treated with estrogen (P < 0.05). Expression of FAK protein was not changed in ESCs after treated by progesterone or treated by estrogen and progesterone. The level of up-regulation by estrogen in endometriosis is significantly higher than that from women without endometriosis (P < 0.05). FAK expression in endometrial stromal cells from endometriosis was more sensitive to estrogen, which might contribute to the pathogenesis and progress of endometriosis.
authors.affiliation: Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou, 310009, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Mu
authors.affiliation: Department of Gynecology, The Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou, 310009, China.
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Ma
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002478:Cells, Cultured; D004715:Endometriosis / Q000201:enzymology* / Q000473:pathology; D004717:Endometrium / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism*; D006801:Humans; D011374:Progesterone / Q000494:pharmacology*; D017154:Stromal Cells / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology
chemical_list: D004967:Estrogens; D011374:Progesterone; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human
keywords: Endometriosis; endometrial stromal cells; focal adhesion kinase; ovarian steroid hormone