title: A patient-specific model of the biomechanics of hip reduction for neonatal Developmental Dysplasia of the Hip: Investigation of strategies for low to severe grades of Developmental Dysplasia of the Hip.
abstract: A physics-based computational model of neonatal Developmental Dysplasia of the Hip (DDH) following treatment with the Pavlik Harness (PV) was developed to obtain muscle force contribution in order to elucidate biomechanical factors influencing the reduction of dislocated hips. Clinical observation suggests that reduction occurs in deep sleep involving passive muscle action. Consequently, a set of five (5) adductor muscles were identified as mediators of reduction using the PV. A Fung/Hill-type model was used to characterize muscle response. Four grades (1-4) of dislocation were considered, with one (1) being a low subluxation and four (4) a severe dislocation. A three-dimensional model of the pelvis-femur lower limb of a representative 10 week-old female was generated based on CT-scans with the aid of anthropomorphic scaling of anatomical landmarks. The model was calibrated to achieve equilibrium at 90° flexion and 80° abduction. The hip was computationally dislocated according to the grade under investigation, the femur was restrained to move in an envelope consistent with PV restraints, and the dynamic response under passive muscle action and the effect of gravity was resolved. Model results with an anteversion angle of 50° show successful reduction Grades 1-3, while Grade 4 failed to reduce with the PV. These results are consistent with a previous study based on a simplified anatomically-consistent synthetic model and clinical reports of very low success of the PV for Grade 4. However our model indicated that it is possible to achieve reduction of Grade 4 dislocation by hyperflexion and the resultant external rotation.
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA.
authors.forename: Victor
authors.initials: V
authors.lastname: Huayamave
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Rose
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA.
authors.forename: Sheila
authors.initials: S
authors.lastname: Serra
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA.
authors.forename: Brendan
authors.initials: B
authors.lastname: Jones
authors.affiliation: Department of Mechanical Engineering, Embry-Riddle Aeronautical University, Daytona Beach, FL 32114, USA.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Divo
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA.
authors.forename: Faissal
authors.initials: F
authors.lastname: Moslehy
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of Central Florida, Orlando, FL 32816, USA. Electronic address: alain.kassab@ucf.edu.
authors.forename: Alain J
authors.initials: AJ
authors.lastname: Kassab
authors.affiliation: Pediatric Orthopedic Surgery, Arnold Palmer Hospital and International Hip Dysplasia Institute (IHDI), Orlando, FL 32806, USA; College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
authors.forename: Charles T
authors.initials: CT
authors.lastname: Price
mesh_terms: D001696:Biomechanical Phenomena; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D006615:Hip / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D006618:Hip Dislocation, Congenital / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D035002:Lower Extremity / Q000000981:diagnostic imaging; D055595:Mechanical Phenomena; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging; D066230:Patient-Specific Modeling; D016059:Range of Motion, Articular; D014057:Tomography, X-Ray Computed
keywords: Developmental Dysplasia of the Hip; Hill muscle model; Hip dysplasia; Non-linear muscle model; Passive muscle behavior; Pavlik Harness; Rigid body dynamics