title: Influence of QRS infarct score and QRS duration prior to transcatheter aortic valve replacement on follow-up left ventricular end systolic volume in patients with new persistent left bundle branch block.
abstract: BACKGROUND
  New-onset left bundle branch block (LBBB) is a known complication during Transcatheter Aortic Valve Replacement (TAVR). This study evaluated the influence of pre-TAVR cardiac conditions on left ventricular functions in patients with new persistent LBBB post-TAVR.
  
  
  METHODS
  Only 11 patients qualified for this study because of the strict inclusion criteria. Pre-TAVR electrocardiograms were evaluated for Selvester QRS infarct score and QRS duration, and left ventricular end-systolic volume (LVESV) was used as outcome variable.
  
  
  RESULTS
  There was a trend towards a positive correlation between QRS score and LVESV of r=0.59 (p=0.058), while there was no relationship between QRS duration and LVESV (r=-0.18 [p=0.59]).
  
  
  CONCLUSIONS
  This study showed that patients with new LBBB and higher pre-TAVR QRS infarct score may have worse post-TAVR left ventricular function, however, pre-TAVR QRS duration has no such predictive value. Because of the small sample size these results should be interpreted with caution and assessed in a larger study population.
authors.affiliation: Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands; Duke Clinical Research Institute, Durham, NC, USA. Electronic address: lgj.hannink@student.maastrichtuniversity.nl.
authors.forename: Laura G J
authors.initials: LG
authors.lastname: Hannink
authors.affiliation: Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Galen S
authors.initials: GS
authors.lastname: Wagner
authors.affiliation: Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Kisslo
authors.affiliation: Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Fawaz Abdulaziz M
authors.initials: FA
authors.lastname: Alenezi
authors.affiliation: Department of Statistics, Duke Clinical Research Institute, Durham, NC, USA.
authors.forename: Linda K
authors.initials: LK
authors.lastname: Shaw
authors.affiliation: Department of Statistics, Duke Clinical Research Institute, Durham, NC, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Hofmann
authors.affiliation: U.S. Food and Drug Administration, Silver Spring, MD, USA.
authors.forename: Robbert
authors.initials: R
authors.lastname: Zusterzeel
authors.affiliation: Department of Statistics, Duke Clinical Research Institute, Durham, NC, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Phelan
authors.affiliation: Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Velazquez
authors.affiliation: Department of Cardiology, Maastricht University Medical Center, Maastricht, The Netherlands.
authors.forename: Anton P M
authors.initials: AP
authors.lastname: Gorgels
mesh_terms: D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000175:diagnosis* / Q000601:surgery*; D002037:Bundle-Branch Block / Q000175:diagnosis* / Q000209:etiology*; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004452:Echocardiography / Q000379:methods; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D065467:Transcatheter Aortic Valve Replacement / Q000009:adverse effects*; D016896:Treatment Outcome
keywords: LBBB; Left bundle branch block; QRS duration; Selvester QRS-score; TAVR; Transcatheter aortic valve replacement