title: Oxidative stress in benign prostate hyperplasia.
abstract: To assess the status of oxidative stress in benign prostate hyperplasia, a very common disease in older men which constitutes a public health problem in Jijel, prostate tissues were obtained by transvesical adenomectomy from 10 men with benign prostate hyperplasia. We measured the cytosolic levels of malondialdehyde (MDA) and glutathione (GSH) and cytosolic enzyme activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S-transferase. The development of benign prostate hyperplasia is accompanied by impaired oxidative status by increasing levels of MDA, depletion of GSH concentrations and a decrease in the activity of all the antioxidant enzymes studied. These results have allowed us to understand a part of the aetiology of benign prostate hyperplasia related to oxidative stress.
authors.affiliation: Laboratory of Molecular Toxicology, Department of Molecular and Cellular Biology, Faculty of Science, University of Jijel, Jijel, Algeria.
authors.forename: N
authors.initials: N
authors.lastname: Zabaiou
authors.affiliation: Urology Service, Mohammed Essedik Benyahiya Jijel Hospital, Jijel, Algeria.
authors.forename: D
authors.initials: D
authors.lastname: Mabed
authors.affiliation: UMR CNRS6293-Clermont University-INSERM U1103 Campus Universitaire des Cézeaux, Cmlermont Ferand, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Lobaccaro
authors.affiliation: Laboratory of Molecular Toxicology, Department of Molecular and Cellular Biology, Faculty of Science, University of Jijel, Jijel, Algeria.
authors.forename: M
authors.initials: M
authors.lastname: Lahouel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione
keywords: Antioxidant enzymes; MDA; benign prostate hyperplasia; glutathione; oxidative stress