title: Effects of a fruit-vegetable dietary pattern on oxidative stress and genetic damage in coke oven workers: a cross-sectional study.
abstract: BACKGROUND
  Coke oven workers (COWs) are exposed to high level of genotoxic chemicals that induce oxidative stress and genetic damage. The dietary intake of certain types of foods may reverse these effects.
  
  
  METHODS
  We conducted a cross-sectional study with 51 topside COWs, 79 other COWs, and 67 controls, to assess the effects of dietary patterns on oxidative stress and genetic damage.
  
  
  RESULTS
  Compared to the controls, both topside and other COWs had significantly higher urinary 1-hydroxypyrene levels, serum oxidant levels [malondialdehyde, (MDA)], and genetic damage [micronucleus (MN) frequency & 8-oxo-2'-deoxyguanosine (8-OH-dG)], but lower antioxidant levels [superoxide dismutase (SOD) and glutathione peroxidase, (GPx)]. The fruit-vegetable (FV) dietary pattern was positively correlated with serum SOD levels and negative correlated with serum MDA, MN frequency, and urinary 8-OH-dG. COWs with an FV patter in the highest quartile (Q4) had significantly increased antioxidant levels (SOD and GPx) and decreased oxidant levels (MDA) and genetic damage (MN frequency and 8-OH-dG) than those with an FV pattern in the lowest quartile (Q1).
  
  
  CONCLUSIONS
  Compared to control subjects, COWs had increased oxidative stress and genetic damage. A FV dietary pattern may reverse oxidative stress and genetic damage in COWs.
authors.affiliation: School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, P. R. China. xiezheng@bjmu.edu.cn.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Taizhou City Center for Disease Control and Prevention, 608 The east China sea avenue, Taizhou city, Zhejiang Province, 318000, P. R. China. linhaijiang@hotmail.com.
authors.forename: Haijiang
authors.initials: H
authors.lastname: Lin
authors.affiliation: School of Public Health, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, P. R. China. frfbjmu@126.com.
authors.forename: Renfei
authors.initials: R
authors.lastname: Fang
authors.affiliation: Taizhou City Center for Disease Control and Prevention, 608 The east China sea avenue, Taizhou city, Zhejiang Province, 318000, P. R. China. shengo8899@126.com.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Shen
authors.affiliation: Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai, 20032, P. R. China. leeshuguang@fudan.edu.cn.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Li
authors.affiliation: Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, 138 Yixueyuan Road, Shanghai, 20032, P. R. China. chenb@fudan.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
mesh_terms: D000328:Adult; D002681:China; D003430:Cross-Sectional Studies; D004249:DNA Damage; D004032:Diet; D005163:Factor Analysis, Statistical; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008297:Male; D008669:Metallurgy; D008875:Middle Aged; D016273:Occupational Exposure; D018384:Oxidative Stress / Q000187:drug effects*; D014675:Vegetables / Q000737:chemistry