title: Zinc Absorption from Fortified Milk Powder in Adolescent Girls.
abstract: Zinc (Zn) is essential for development, growth, and reproduction. The Mexican government subsidizes micronutrient-fortified milk for risk groups, with positive effect on the targeted groups' plasma Zn level, inferring a good absorption is achieved although it has not being measured. The aim of this study was to determine the impact of micronutrient-fortified milk intake during 27 days on Zn absorption in adolescent girls from northwest Mexico. Therefore, Zn absorption was evaluated in 14 healthy adolescent girls (14.1 years old) with adequate plasma Zn levels, before and after 27 days of fortified Zn milk intake. Fractional Zn absorption (FZA) was calculated from urinary ratios of stable isotopic Zn tracers administered orally and intravenously on days 0 and 27, and total absorbed Zn (TZA) was calculated. At the beginning, Zn intake was 6.8 ± 0.85 mg/d (mean ± SE), and 50 % of the adolescent girls did not achieve their requirement (7.3 mg/d). Additionally, FZA was negatively correlated with Zn intake (r =-0.61, p = 0.02), while TZA (1.06 mg/d) was insufficient to cover the physiologic requirements of adolescent girls (3.02 mg/d). At the end of the intervention, all the girls reached the Zn intake recommendation and TZA, 3.09 mg/d, which was enough to meet the physiological requirement for 57 % of the adolescent girls. Therefore, the low Zn intake and the Zn status of adolescent girls were positively impacted by Zn-fortified milk intake and its good absorption rate.
authors.affiliation: Centro de Investigación en Alimentación y Desarrollo, A.C. Carretera a La Victoria km 0.6, PO Box 1735, 83304, Hermosillo, SON, Mexico. romendez@ciad.mx.
authors.forename: Rosa O
authors.initials: RO
authors.lastname: Méndez
authors.affiliation: Center for Human Nutrition and Health Sciences Center, University of Colorado, C-225, 4200 E Ninth Avenue, Denver, CO, 80262, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Hambidge
authors.affiliation: Department of Geosciences, University of Arizona, 1040 E. 4th Street, Tucson, AZ, 85721, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Baker
authors.affiliation: Department of Geosciences, University of Arizona, 1040 E. 4th Street, Tucson, AZ, 85721, USA.
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Salgado
authors.affiliation: Department of Geosciences, University of Arizona, 1040 E. 4th Street, Tucson, AZ, 85721, USA.
authors.forename: Joaquín
authors.initials: J
authors.lastname: Ruiz
authors.affiliation: UNIDA, Instituto Tecnológico de Veracruz, Calz. Miguel Ángel de Quevedo 2779, Formando Hogar, 91860, Veracruz, VER, Mexico.
authors.forename: Hugo S
authors.initials: HS
authors.lastname: García
authors.affiliation: Centro de Investigación en Alimentación y Desarrollo, A.C. Carretera a La Victoria km 0.6, PO Box 1735, 83304, Hermosillo, SON, Mexico.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Calderón de la Barca
mesh_terms: D000293:Adolescent; D000818:Animals; D003611:Dairy Products; D004032:Diet; D005260:Female; D005527:Food, Fortified; D006801:Humans; D007408:Intestinal Absorption; D008800:Mexico; D008892:Milk / Q000378:metabolism*; D015032:Zinc / Q000493:pharmacokinetics* / Q000652:urine; D015033:Zinc Isotopes
chemical_list: D015033:Zinc Isotopes; D015032:Zinc
keywords: Adolescent girls; Micronutrient-fortified milk; Physiological requirement; Total absorbed zinc