title: Modeling-based determination of physiological parameters of systemic VOCs by breath gas analysis: a pilot study.
abstract: In this paper we develop a simple two compartment model which extends the Farhi equation to the case when the inhaled concentration of a volatile organic compound (VOC) is not zero. The model connects the exhaled breath concentration of systemic VOCs with physiological parameters such as endogenous production rates and metabolic rates. Its validity is tested with data obtained for isoprene and inhaled deuterated isoprene-D5.
authors.affiliation: Breath Research Institute, University of Innsbruck, Rathausplatz 4, A-6850 Dornbirn, Austria. University of Applied Sciences Vorarlberg, Hochschulstr. 1, A-6850 Dornbirn, Austria.
authors.forename: Karl
authors.initials: K
authors.lastname: Unterkofler
authors.forename: Julian
authors.initials: J
authors.lastname: King
authors.forename: Pawel
authors.initials: P
authors.lastname: Mochalski
authors.forename: Martin
authors.initials: M
authors.lastname: Jandacka
authors.forename: Helin
authors.initials: H
authors.lastname: Koc
authors.forename: Susanne
authors.initials: S
authors.lastname: Teschl
authors.forename: Anton
authors.initials: A
authors.lastname: Amann
authors.forename: Gerald
authors.initials: G
authors.lastname: Teschl
mesh_terms: D000096:Acetone / Q000737:chemistry*; D001944:Breath Tests / Q000295:instrumentation* / Q000379:methods; D002070:Butadienes / Q000737:chemistry*; D045853:Exhalation / Q000502:physiology*; D005260:Female; D045782:Hemiterpenes / Q000737:chemistry*; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D010420:Pentanes / Q000737:chemistry*; D010865:Pilot Projects; D055549:Volatile Organic Compounds / Q000737:chemistry*
chemical_list: D002070:Butadienes; D045782:Hemiterpenes; D010420:Pentanes; D055549:Volatile Organic Compounds; C005059:isoprene; D000096:Acetone