title: GDF-15 prevents ventilator-induced lung injury by inhibiting the formation of platelet-neutrophil aggregates.
authors.forename: J M
authors.initials: JM
authors.lastname: Herter
authors.forename: F
authors.initials: F
authors.lastname: Kraft
authors.forename: H
authors.initials: H
authors.lastname: Van Aken
authors.forename: M
authors.initials: M
authors.lastname: Meersch
authors.forename: A
authors.initials: A
authors.lastname: Zarbock
authors.affiliation: Jan Rossaint, MD, University of Münster, Department of Anaesthesiology, Intensive Care and Pain Medicine, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany, Tel.: +49 251 8347252, Fax: +49 251 88704, E-mail: rossaint@uni-muenster.de.
authors.forename: J
authors.initials: J
authors.lastname: Rossaint
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D002199:Capillary Permeability; D002448:Cell Adhesion; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D065206:Extracellular Traps / Q000187:drug effects; D055436:Growth Differentiation Factor 15 / Q000172:deficiency / Q000235:genetics / Q000494:pharmacology* / Q000627:therapeutic use; D008168:Lung / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018482:Muscle, Skeletal / Q000473:pathology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010973:Platelet Adhesiveness / Q000187:drug effects / Q000502:physiology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D017713:Platelet Transfusion; D011654:Pulmonary Edema / Q000503:physiopathology / Q000517:prevention & control; D011659:Pulmonary Gas Exchange; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011828:Radiation Chimera; D000077466:Tirofiban; D014443:Tyrosine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D055397:Ventilator-Induced Lung Injury / Q000235:genetics / Q000503:physiopathology / Q000517:prevention & control*
chemical_list: D055436:Growth Differentiation Factor 15; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D012333:RNA, Messenger; D014443:Tyrosine; D000077466:Tirofiban