title: Inflammatory cytokine levels in patients with periodontitis and/or coronary heart disease.
abstract: The purpose of this study was to investigate systemic and local levels of four classic inflammatory cytokines (IL-1β, MCP-1, VEGF, PDGF) in patients with periodontitis and coronary heart disease (CHD). 109 volunteers were enrolled and the condition of their periodontal tissue and coronary artery were assessed. The patients were then divided into four distinct groups: periodontitis only, CHD only, periodontitis with CHD, and healthy controls. Gingival crevicular fluid (GCF) and venous blood were collected. The concentrations of cytokines were detected meanwhile by specific ELISA. The IL-1β and MCP-1 concentrations in the serum and GCF of the three disease groups were significantly higher than those in the control group (P ≤ 0.05). Serum VEGF concentrations of the patients with existing disease was lower than that of the controls. VEGF levels in the GCF of all disease groups were significantly higher than that of the control group (P ≤ 0.05).
authors.affiliation: Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University China.
authors.forename: Haihua
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University China.
authors.forename: Pei
authors.initials: P
authors.lastname: Zheng
authors.affiliation: Department of Conservative Dentistry and Periodontics, Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University China.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
mesh_terms: D000328:Adult; D018932:Chemokine CCL2 / Q000032:analysis / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D053583:Interleukin-1beta / Q000032:analysis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood* / Q000150:complications; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis / Q000097:blood*
chemical_list: D018932:Chemokine CCL2; D053583:Interleukin-1beta; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A
keywords: Interleukin-1β (IL-1β); coronary heart disease; monocyte chemoattractant protein-1 (MCP-1); periodontal disease; platelet-derived growth factor (PDGF); vascular endothelial growth factor (VEGF)