title: Stem cell-based therapies for intracerebral hemorrhage in animal model: a meta-analysis.
abstract: Stem cell to be a new intervention for treating intracerebral hemorrhage (ICH) might benefit humans. Therefore, we collected animal studies to find the effect of this innovative treatment. In July 2014, we searched Medline (from 1950), Embase (from 1980), China Biology Medicine disk (from 1978) for studies on stem cells used for treating experimental ICH in animal models that reported neurobehavioral and structural outcome. We evaluated the quality of these studies and used a weighted mean difference random affects model for the meta-analysis. We have collected 30 studies from 650 publications identified through systematic review describing the effects of 5 different type of stem cells on 12 different neurobehavioral scales with 1101 rodents or monkeys. Although there is lack of uniformity of the evaluation methods, these researches showed consistent improvements both in neurobehavioral function and structural outcomes. Besides, the quality of these studies needs to be raised. In conclusion, stem cells hold extensive potential in treating ICH, which should be further evaluated with more evidence-based, high-quality animal studies.
authors.affiliation: Third Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, People's Republic of China, maxun_oppo@163.com.
authors.forename: Xun
authors.initials: X
authors.lastname: Ma
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.forename: Changhe
authors.initials: C
authors.lastname: Shi
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Xinjing
authors.initials: X
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Ji
authors.forename: Wei
authors.initials: W
authors.lastname: Ji
authors.forename: Guangming
authors.initials: G
authors.lastname: Gong
authors.forename: Yuming
authors.initials: Y
authors.lastname: Xu
mesh_terms: D000818:Animals; D002543:Cerebral Hemorrhage / Q000628:therapy*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D004195:Disease Models, Animal; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology*