title: Leptin, adipocytes and breast cancer: Focus on inflammation and anti-tumor immunity.
abstract: More than one million new cases of breast cancer are diagnosed worldwide each year and more than 400,000 deaths are caused by the disease. The origin of this pathology is multifactorial and involved genetic, hormonal, environmental and nutritional factors including obesity in postmenopausal women. The role played by the adipose tissue and their secretions, ie adipokines, is beginning to be recognized. Plasma adipokine levels, which are modulated during obesity, could have “remote” effects on mammary carcinogenesis. Breast cancer cells are surrounded and locally influenced by an adipocyte microenvironment, which is probably more extensive in obese people. Hence, leptin appears to be strongly involved in mammary carcinogenesis and may contribute to the local pro-inflammatory mechanisms, especially in obese patients, who have increased metastatic potential and greater risk of mortality. This review presents the multifaceted role of leptin in breast cancer development and the different molecular pathways involved such as inflammation, oxidative stress and antitumor immunity.
authors.affiliation: Clermont Université, Université d'Auvergne, UFR Pharmacie, 28 place Henri Dunant, 63000 Clermont-Ferrand, France; INRA, UMR 1019, ECREIN, CRNH Auvergne, 63000 Clermont-Ferrand, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Delort
authors.affiliation: Clermont Université, Université d'Auvergne, UFR Pharmacie, 28 place Henri Dunant, 63000 Clermont-Ferrand, France; INRA, UMR 1019, ECREIN, CRNH Auvergne, 63000 Clermont-Ferrand, France.
authors.forename: Adrien
authors.initials: A
authors.lastname: Rossary
authors.affiliation: Clermont Université, Université d'Auvergne, UFR Pharmacie, 28 place Henri Dunant, 63000 Clermont-Ferrand, France; INRA, UMR 1019, ECREIN, CRNH Auvergne, 63000 Clermont-Ferrand, France.
authors.forename: Marie-Chantal
authors.initials: MC
authors.lastname: Farges
authors.affiliation: Clermont Université, Université d'Auvergne, UFR Pharmacie, 28 place Henri Dunant, 63000 Clermont-Ferrand, France; INRA, UMR 1019, ECREIN, CRNH Auvergne, 63000 Clermont-Ferrand, France; Centre Jean-Perrin, CHU Gabriel-Montpied, Unité de Nutrition, 63003 Clermont-Ferrand, France.
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Vasson
authors.affiliation: Clermont Université, Université d'Auvergne, UFR Pharmacie, 28 place Henri Dunant, 63000 Clermont-Ferrand, France; INRA, UMR 1019, ECREIN, CRNH Auvergne, 63000 Clermont-Ferrand, France. Electronic address: Florence.caldefie-chezet@udamail.fr.
authors.forename: Florence
authors.initials: F
authors.lastname: Caldefie-Chézet
mesh_terms: D017667:Adipocytes / Q000502:physiology*; D001943:Breast Neoplasms / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D020738:Leptin / Q000502:physiology*
chemical_list: D020738:Leptin
keywords: Adipocytes; Breast cancer; Immunity; Leptin; NK cells; Oxidative stress