title: Size-dependent active effect of cadmium telluride quantum dots on luminol-potassium periodate chemiluminescence system for levodopa detection.
abstract: It was found that cadmium telluride (CdTe) quantum dots (QDs) with different sizes can have a great sensitizing effect on chemiluminescence (CL) emission from luminol-potassium periodate (KIO4) system. Levodopa, a widely prescribed drug in the treatment of Parkinson's disease, could inhibit luminol-KIO4-CdTe QDs CL reaction in alkaline solution. The inhibited CL intensity was proportional to the concentration of levodopa in the range from 8.0 nM to 10.0 μM. The detection limit was 3.8 nM. This method has been successfully applied to determine levodopa in pharmaceutical preparation and human urine and plasma samples with recoveries of 94.1-105.4%. This was the first work for inhibition effect determination of levodopa using a QD-based CL method.
authors.affiliation: Editorial Department of Journal, Shanxi Normal University, Linfen 041004, Shanxi, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Cui
authors.forename: Suqin
authors.initials: S
authors.lastname: Han
authors.forename: Fang
authors.initials: F
authors.lastname: Hao
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D004867:Equipment Design; D006801:Humans; D007980:Levodopa / Q000097:blood / Q000652:urine; D057230:Limit of Detection; D016014:Linear Models; D008163:Luminescent Measurements / Q000379:methods*; D008165:Luminol / Q000737:chemistry; D010316:Particle Size; D010504:Periodic Acid / Q000737:chemistry; D017680:Potassium Compounds / Q000737:chemistry; D045663:Quantum Dots / Q000737:chemistry*; D015203:Reproducibility of Results; D013691:Tellurium / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D017680:Potassium Compounds; D010504:Periodic Acid; D007980:Levodopa; D008165:Luminol; D013691:Tellurium; C037192:potassium periodate; C028337:cadmium telluride