title: Association between Several Persistent Organic Pollutants and Thyroid Hormone Levels in Cord Blood Serum and Bloodspot of the Newborn Infants of Korea.
abstract: Current knowledge on adverse endocrine disruption effects of persistent organic pollutants (POPs) among newborn infants is limited and often controversial. To investigate the associations between prenatal exposure to major POPs and thyroid hormone levels among newborn infants, both cord serum or maternal serum concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs) were compared with five thyroid hormones in cord serum of newborn infants as well as TSH in bloodspot collected at 2 day after birth (n=104). Since cord serum thyroid hormones could be affected by those of mothers, thyroid hormone concentrations of the matching mothers at delivery were adjusted. In cord serum, BDE-47, -99, and Σchlordane (CHD) showed significant positive associations with cord or bloodspot TSH. At the same time, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) and hexachlorbenzene (HCB) showed negative associations with total T3 and total T4 in cord serum, respectively. Maternal exposure to β-hexachlorhexane (β-HCH), ΣCHD, ΣDDT, or p,p'-DDE were also associated with neonatal thyroid hormones. Although the sample size is small and the thyroid hormone levels of the subjects were within the reference range, our observation supports thyroid disrupting potential of several POPs among newborn infants, at the levels occurring in the general population. Considering the importance of thyroid hormones during gestation and early life stages, health implication of thyroid hormone effects by low level POPs exposure deserves further follow up investigations.
authors.affiliation: School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Sunmi
authors.initials: S
authors.lastname: Kim
authors.affiliation: College of Natural Sciences, Soonchunhyang University, Asan, Chungcheong, Republic of Korea.
authors.forename: Jeongim
authors.initials: J
authors.lastname: Park
authors.affiliation: College of Medicine, Korea University, Seoul, Republic of Korea.
authors.forename: Hai-Joong
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
authors.forename: Jeong Jae
authors.initials: JJ
authors.lastname: Lee
authors.affiliation: College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
authors.forename: Gyuyeon
authors.initials: G
authors.lastname: Choi
authors.affiliation: College of Medicine, Inha University, Incheon, Republic of Korea.
authors.forename: Sooran
authors.initials: S
authors.lastname: Choi
authors.affiliation: College of Medicine, Hallym University, Seoul, Republic of Korea.
authors.forename: Sungjoo
authors.initials: S
authors.lastname: Kim
authors.affiliation: College of Medicine, Jeju National University, Jeju, Republic of Korea.
authors.forename: Su Young
authors.initials: SY
authors.lastname: Kim
authors.affiliation: College of Science and Technology, Hanyang University, Ansan, Gyeonggi, Republic of Korea.
authors.forename: Hyo-Bang
authors.initials: HB
authors.lastname: Moon
authors.affiliation: School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Sungkyoon
authors.initials: S
authors.lastname: Kim
authors.affiliation: School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Kyungho
authors.initials: K
authors.lastname: Choi
mesh_terms: D000328:Adult; D017606:Chlorine Compounds / Q000097:blood; D052244:Endocrine Disruptors / Q000097:blood*; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D055768:Halogenated Diphenyl Ethers / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D008875:Middle Aged; D010575:Pesticides / Q000097:blood / Q000737:chemistry; D011078:Polychlorinated Biphenyls / Q000097:blood; D011247:Pregnancy; D056910:Republic of Korea; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D017606:Chlorine Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D010575:Pesticides; D013963:Thyroid Hormones; D011078:Polychlorinated Biphenyls