title: Kinetics and Immunodominance of Virus-Specific T Cell Responses During Hantaan Virus Infection.
abstract: Immunodominant T cell responses are important for protection against virus challenge. However, studies screening for the immunodominant T cell responses and following their kinetics in acute Hantaan virus (HTNV) infection are very limited. Herein, the HTNV nucleocapsid protein-specific T cell responses were longitudinally screened in 15 patients with acute HTNV infection, eight of whom had a particularly severe hemorrhagic fever with renal syndrome (HFRS). An extremely impaired IFN-γ-producing T cell response was observed in patients with severe HFRS at the early stage of infection, especially to the immunodominant epitopes detected in the mild to moderate group, namely peptides N127-141, N139-153, N241-255, and N355-369. The initially insufficient T cell response to the immunodominant epitopes may play a role in influencing the severity of HTNV infection. These findings provide information that may aid the design of future vaccines against hantaviruses.
authors.affiliation: 1Center for Experimental Medicine, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou, China.
authors.forename: Meiliang
authors.initials: M
authors.lastname: Wang
authors.affiliation: 2Department of Infectious Diseases, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
authors.forename: Jiuping
authors.initials: J
authors.lastname: Wang
authors.affiliation: 3Department of Colorectal and Anal Surgery, The First Hospital of Jilin University, Changchun, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Kang
authors.affiliation: 4Department of Nutriment, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou, China.
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: 1Center for Experimental Medicine, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou, China.|5Gansu Key Laboratory of Stem Cell and Gene Therapy, Lanzhou, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wang
authors.affiliation: 1Center for Experimental Medicine, Lanzhou General Hospital, Lanzhou Military Command, Lanzhou, China.|5Gansu Key Laboratory of Stem Cell and Gene Therapy, Lanzhou, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Hui
mesh_terms: D000328:Adult; D000368:Aged; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D036022:Capsid Proteins / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D005260:Female; D018063:Hantaan virus / Q000276:immunology*; D018778:Hantavirus Infections / Q000276:immunology* / Q000821:virology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology / Q000821:virology; D006801:Humans; D016056:Immunodominant Epitopes / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014758:Viral Core Proteins / Q000276:immunology*; D055815:Young Adult
chemical_list: D036022:Capsid Proteins; D018984:Epitopes, T-Lymphocyte; D016056:Immunodominant Epitopes; D014758:Viral Core Proteins; C111782:nucleocapsid protein, Hantaan virus; D007371:Interferon-gamma