title: Prognostic significance of preoperative platelet count in patients with gallbladder cancer.
abstract: OBJECTIVE
  To investigate the prognostic value of preoperative platelet count (PLT) in patients with primary gallbladder cancer (GBC).
  
  
  METHODS
  The clinical data of 223 GBC patients after surgery was retrospectively reviewed. A receiver operating characteristic (ROC) curve was plotted to verify the optimum cutoff point for PLT. Univariate and multivariate survival analyses were performed to identify the factors associated with the prognosis.
  
  
  RESULTS
  The ROC curve showed that the optimum cutoff point for PLT was 178 × 10(9)/L, and the entire cohort was stratified into group A with PLT > 178 × 10(9)/L and group B with PLT ≤ 178 × 10(9)/L. Group A had a better survival than group B (P < 0.001). There was an obvious difference between the two groups in terms of the differentiation degree, advanced tumor stage, lymph node metastasis (P < 0.001) and pathological type (P < 0.05). The univariate analysis demonstrated that tumor location, differentiation degree, TNM stage, Nevin stage, lymph node metastasis and PLT were associated with overall survival (P < 0.001). In the multivariate analysis, PLT (P = 0.032), lymph node metastasis (P = 0.007), tumor location (P < 0.001) and TNM stage (P = 0.005) were independent prognostic factors.
  
  
  CONCLUSIONS
  PLT is closely correlated with GBC prognosis and could be used to identify the population with a poorer prognosis after surgery.
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Rui-Tao
authors.initials: RT
authors.lastname: Wang
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Ling-Qiang
authors.initials: LQ
authors.lastname: Zhang
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Mu
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Li
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Xin-Sen
authors.initials: XS
authors.lastname: Xu
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Pang
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Lian-Kang
authors.initials: LK
authors.lastname: Sun
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Shun-Bin
authors.initials: SB
authors.lastname: Dong
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Rui-Tao Wang, Ling-Qiang Zhang, Xin-Sen Xu, Qing Pang, Lian-Kang Sun, Xing Zhang, Shun-Bin Dong, Lin Wang, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an 710061, Shaanxi Province, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001792:Blood Platelets; D002277:Carcinoma / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D002454:Cell Differentiation; D016009:Chi-Square Distribution; D005260:Female; D005706:Gallbladder Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010976:Platelet Count; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: Gallbladder cancer; Platelet count; Prognostic factor; Survival