title: Potential protection of taurine on antioxidant system and ATPase in brain and blood of rats exposed to aluminum.
abstract: OBJECTIVE
  Taurine (Tau) is used in clinical treatments but its protection of brains against aluminum-induced oxidative damage has been explored for the first time. The positive effect of Tau was studied on the activities of antioxidant enzymes and ATPase.
  
  
  RESULTS
  Aluminum (Al) intake caused significant increasement of malondialdehyde (MDA) but reduction of the activities of superoxide dismutase, glutathione peroxidase (GSH-Px), Na(+)K(+)-ATPase and Mg(2+)-ATPase in brain compared to control group (P < 0.05). Tau administration, however, significantly reduced the MDA content, and increased the activities of aforementioned enzymes (P < 0.05). The MDA content was higher and the activities of GSH-Px, Ca(2+)-ATPase and Mg(2+)-ATPase lower in the blood of the Al-treated group' (P < 0.05), while Tau markedly decreased MDA content and improved the activities of GSH-Px and Ca(2+)-ATPase (P < 0.05).
  
  
  CONCLUSIONS
  Tau may play a crucial role in the protection of antioxidant system and ATPase against Al-induced toxicity in brain and blood of rats.
authors.affiliation: Department of Hygiene Detection, College of Public Health, Shandong University, Jinan, Shandong, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Qiao
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Ren
authors.forename: Tong
authors.initials: T
authors.lastname: Feng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000251:Adenosine Triphosphatases / Q000032:analysis*; D000535:Aluminum / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D001774:Blood Chemical Analysis; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects*; D008315:Malondialdehyde / Q000032:analysis; D011041:Poisoning / Q000517:prevention & control*; D051381:Rats; D013654:Taurine / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D013654:Taurine; D008315:Malondialdehyde; D000535:Aluminum; D000251:Adenosine Triphosphatases