title: Metabolomics in cardiovascular diseases.
abstract: Cardiovascular diseases (CVDs) are the main cause of death globally. There is a need for the development of specific diagnostic methods, more effective therapeutic procedures as well as drugs, which can decrease the risk of deaths in the course of CVDs. For this reason, better understanding and explanation of molecular pathomechanisms of CVDs are essential. Metabolomics is focused on analysis of metabolites, small molecules which reflect the state of an organism in a certain point of time. Application of metabolomics approach in the investigation of molecular processes responsible for CVDs development may provide valuable information. In this article we overviewed recent reports employing application of untargeted and targeted metabolomic analyses in particular CVDs. Moreover, we focused on applications of various analytical platforms and metabolomics approaches which may contribute to the explanation of the pathomechanisms of different cardiovascular diseases.
authors.affiliation: Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416, Gdańsk, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Kordalewska
authors.affiliation: Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416, Gdańsk, Poland. Electronic address: markusz@gumed.edu.pl.
authors.forename: Michał J
authors.initials: MJ
authors.lastname: Markuszewski
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D055432:Metabolomics / Q000379:methods* / Q000639:trends
keywords: Biomarkers; Cardiovascular diseases; Metabolomics; Systems biology