title: Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242.
abstract: Two new apoptolidins, 2'-O-succinyl-apoptolidin A (11) and 3'-O-succinyl-apoptolidin A (12), were isolated from the culture broth of an Indonesian Amycolatopsis sp. ICBB 8242. These compounds inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A (1), they do not inhibit cellular respiration in H292 cells. It is proposed that apoptolidins are produced and secreted in their succinylated forms and 1 is the hydrolysis product of 11 and 12.
authors.affiliation: †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sheng
authors.affiliation: †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
authors.forename: Serge
authors.initials: S
authors.lastname: Fotso
authors.affiliation: †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Serrill
authors.affiliation: ‡Indonesian Center for Biodiversity and Biotechnology, ICBB-Complex, Jl. Cilubang Nagrak No. 62, Situgede, Bogor 16115, Indonesia.
authors.forename: Salmah
authors.initials: S
authors.lastname: Shahab
authors.affiliation: ‡Indonesian Center for Biodiversity and Biotechnology, ICBB-Complex, Jl. Cilubang Nagrak No. 62, Situgede, Bogor 16115, Indonesia.|§Department of Soil Science and Land Resources, Faculty of Agriculture, Bogor Agricultural University, Bogor, Indonesia.
authors.forename: Dwi Andreas
authors.initials: DA
authors.lastname: Santosa
authors.affiliation: †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Ishmael
authors.affiliation: †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Proteau
authors.affiliation: †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
authors.forename: T Mark
authors.initials: TM
authors.lastname: Zabriskie
authors.affiliation: †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
authors.forename: Taifo
authors.initials: T
authors.lastname: Mahmud
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007214:Indonesia; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D018942:Macrolides; C114125:apoptolidin