title: Clinical Application of Induced Pluripotent Stem Cells in Cardiovascular Medicine.
abstract: Induced pluripotent stem cells (iPSCs) are generated by reprogramming human somatic cells through the overexpression of four transcription factors: Oct4, Sox2, Klf4 and c-Myc. iPSCs are capable of indefinite self-renewal, and they can differentiate into almost any type of cell in the body. These cells therefore offer a highly valuable therapeutic strategy for tissue repair and regeneration. Recent experimental and preclinical research has revealed their potential for cardiovascular disease diagnosis, drug screening and cellular replacement therapy. Nevertheless, significant challenges remain in terms of the development and clinical application of human iPSCs. Here, we review current progress in research related to patient-specific iPSCs for ex vivo modeling of cardiovascular disorders and drug screening, and explore the potential of human iPSCs for use in the field of cardiovascular regenerative medicine.
authors.affiliation: Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Hong-jie
authors.initials: HJ
authors.lastname: Chi
authors.forename: Song
authors.initials: S
authors.lastname: Gao
authors.forename: Xin-chun
authors.initials: XC
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Cai
authors.forename: Wen-shu
authors.initials: WS
authors.lastname: Zhao
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Yong-Jian
authors.initials: YJ
authors.lastname: Geng
mesh_terms: D002318:Cardiovascular Diseases / Q000628:therapy*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D000090062:Kruppel-Like Factor 4; D012038:Regeneration