title: Transdermal estradiol treatment during breastfeeding: maternal and infant serum concentrations.
abstract: We examined estradiol (E2) and estrone (E1) concentrations in breastfeeding mother-infant dyads. The mothers had postpartum depression and were participants in a randomized clinical trial with three treatments (transdermal E2, sertraline, and placebo). Neither infant E1 and E2 concentrations nor infant growth differed across the treatments. Transdermal E2 administration of 50 to 200 mcg/day for breastfeeding women did not affect infant E1 or E2 concentrations or infant growth.
authors.affiliation: Asher Center for the Study and Treatment of Depressive Disorders, Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 676. N. St. Clair Street, Suite 1000, Chicago, IL, 60611, USA. emily.pinheiro@northwestern.edu.
authors.forename: Emily
authors.initials: E
authors.lastname: Pinheiro
authors.affiliation: Department of Pediatrics, Division of General Academic Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: Debra L
authors.initials: DL
authors.lastname: Bogen
authors.affiliation: Asher Center for the Study and Treatment of Depressive Disorders, Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 676. N. St. Clair Street, Suite 1000, Chicago, IL, 60611, USA.
authors.forename: Denada
authors.initials: D
authors.lastname: Hoxha
authors.affiliation: Asher Center for the Study and Treatment of Depressive Disorders, Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 676. N. St. Clair Street, Suite 1000, Chicago, IL, 60611, USA.
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Wisner
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D001942:Breast Feeding; D019052:Depression, Postpartum / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood*; D004970:Estrone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016032:Randomized Controlled Trials as Topic; D020280:Sertraline / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004970:Estrone; D004958:Estradiol; D020280:Sertraline
keywords: Breastfeeding; Estradiol; Infant; Major depressive disorder; Postpartum depression