title: Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity.
abstract: Disruption of circadian rhythmicity is associated with obesity and related disorders, including type 2 diabetes and cardiovascular disease. Specifically, prolonged artificial light exposure associates with obesity in humans, although the underlying mechanism is unclear. Here, we report that increasing the daily hours of light exposure increases body adiposity through attenuation of brown adipose tissue (BAT) activity, a major contributor of energy expenditure. Mice exposed to a prolonged day length of 16- and 24-h light, compared with regular 12-h light, showed increased adiposity without affecting food intake or locomotor activity. Mechanistically, we demonstrated that prolonged day length decreases sympathetic input into BAT and reduces β3-adrenergic intracellular signaling. Concomitantly, prolonging day length decreased the uptake of fatty acids from triglyceride-rich lipoproteins, as well as of glucose from plasma selectively by BAT. We conclude that impaired BAT activity is an important mediator in the association between disturbed circadian rhythm and adiposity, and anticipate that activation of BAT may overcome the adverse metabolic consequences of disturbed circadian rhythmicity.
authors.affiliation: Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, and s.kooijman@lumc.nl.
authors.forename: Sander
authors.initials: S
authors.lastname: Kooijman
authors.affiliation: Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, and.
authors.forename: Rosa
authors.initials: R
authors.lastname: van den Berg
authors.affiliation: Department of Molecular Cell Biology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands; and.
authors.forename: Ashna
authors.initials: A
authors.lastname: Ramkisoensing
authors.affiliation: Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, and.
authors.forename: Mariëtte R
authors.initials: MR
authors.lastname: Boon
authors.affiliation: Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, and.
authors.forename: Eline N
authors.initials: EN
authors.lastname: Kuipers
authors.affiliation: Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, and.
authors.forename: Marieke
authors.initials: M
authors.lastname: Loef
authors.affiliation: Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, and.
authors.forename: Tom C M
authors.initials: TC
authors.lastname: Zonneveld
authors.affiliation: Department of Molecular Cell Biology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands; and.
authors.forename: Eliane A
authors.initials: EA
authors.lastname: Lucassen
authors.affiliation: Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, and.
authors.forename: Hetty C M
authors.initials: HC
authors.lastname: Sips
authors.affiliation: Laboratory of Genetic Metabolic Diseases, Academic Medical Center, Amsterdam 1105AZ, The Netherlands.
authors.forename: Iliana A
authors.initials: IA
authors.lastname: Chatzispyrou
authors.affiliation: Laboratory of Genetic Metabolic Diseases, Academic Medical Center, Amsterdam 1105AZ, The Netherlands.
authors.forename: Riekelt H
authors.initials: RH
authors.lastname: Houtkooper
authors.affiliation: Department of Molecular Cell Biology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands; and.
authors.forename: Johanna H
authors.initials: JH
authors.lastname: Meijer
authors.affiliation: Department of Molecular Cell Biology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands; and.
authors.forename: Claudia P
authors.initials: CP
authors.lastname: Coomans
authors.affiliation: Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, and.
authors.forename: Nienke R
authors.initials: NR
authors.lastname: Biermasz
authors.affiliation: Department of Medicine, Division of Endocrinology, Einthoven Laboratory for Experimental Vascular Medicine, and.
authors.forename: Patrick C N
authors.initials: PC
authors.lastname: Rensen
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology*; D002001:Adipose Tissue, Brown / Q000294:innervation / Q000378:metabolism* / Q000473:pathology*; D050154:Adiposity / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D021081:Chronobiology Disorders / Q000150:complications / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology; D004435:Eating; D004734:Energy Metabolism / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D009765:Obesity / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D017440:Photoperiod; D022702:Receptors, Adrenergic, beta-3 / Q000378:metabolism; D015398:Signal Transduction; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D008074:Lipoproteins; D022702:Receptors, Adrenergic, beta-3; D014280:Triglycerides; C030087:lipoprotein triglyceride
keywords: brown adipose tissue; circadian rhythms; light pollution; obesity; triglyceride metabolism