title: Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed on Integrated Backscatter Intravascular Ultrasound.
abstract: BACKGROUND
  Uremic toxin has emerged as an important determinant of cardiovascular risk. The aim of this study was to examine the relationship between serum uremic toxin and coronary plaque composition on integrated backscatter intravascular ultrasound (IB-IVUS).
  
  
  RESULTS
  IB-IVUS was performed in 47 patients with planned treatment for angina pectoris. Non-culprit intermediate plaque analyzed in this study had to be >5 mm apart from the intervention site. 3-D IB-IVUS analysis was performed to determine percent lipid volume (LV) and fibrous volume (FV). We also measured serum uremic toxins (indoxyl sulfate [IS], asymmetric dimethylarginine [ADMA], and p-cresol [PC]). Glomerular filtration rate correlated with IS (r=-0.329, P=0.04), but did not correlate with ADMA or PC. Percent LV correlated with IS (r=0.365, P=0.02), but did not correlate with ADMA or PC. Percent FV also correlated with IS (r=-0.356, P=0.03), but did not correlate with ADMA or PC. On multivariate regression, only IS was associated with percent LV (r=0.359, P=0.04) and percent FV (r=-0.305, P=0.04) independently of potentially confounding coronary risk factors.
  
  
  CONCLUSIONS
  Among the uremic toxins, serum IS might be a novel useful biomarker to detect and monitor lipid-rich coronary plaque on IB imaging.
authors.affiliation: Department of Cardiovascular Medicine, Tokushima University Hospital.
authors.forename: Hiromu
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Koji
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Soeki
authors.forename: Tetsuzo
authors.initials: T
authors.lastname: Wakatsuki
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Niki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Taketani
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kitaoka
authors.forename: Kenya
authors.initials: K
authors.lastname: Kusunose
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ise
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tobiume
authors.forename: Shusuke
authors.initials: S
authors.lastname: Yagi
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwase
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Yamada
authors.forename: Masataka
authors.initials: M
authors.lastname: Sata
mesh_terms: D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007200:Indican / Q000097:blood*; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000000981:diagnostic imaging; D012307:Risk Factors; D018084:Ultrasonography, Interventional
chemical_list: D015415:Biomarkers; C018524:N,N-dimethylarginine; D001120:Arginine; D007200:Indican