title: [Comparison of thromboelastography and routine coagulation tests for evaluation of blood coagulation function in patients].
abstract: OBJECTIVE
  To investigate the correlation and consistency between thromboelastography(TEG) and routine coagulation tests, and to evaluate the value of the two methods in determining the blood coagulation of patients.
  
  
  METHODS
  The TEG, routine coagulation tests and platelet counts of 182 patients from the Intensive Care Unit(ICU) and Department of Gastroenterology in our hospital from January to September 2014 were performed and analyzed retrospectively for their correlation, Kappa identity test analysis and chi-square test, and the diagnostic sensitivity and specificity of both methods in the patients with bleeding were evaluated.
  
  
  RESULTS
  The TEG R time and PT, R time and APTT showed a linear dependence (P<0.01). The relationship between the TEG K value, α-Angle, MA and Fibrinogen showed a linear dependence (P<0.001). And the relationship between the TEG K value, α-Angle, MA and the platelet count were in a linear dependent way (P<0.001). The Kappa values of the TEG R time with PT and APTT were 0.038 (P>0.05) and 0.061 (P>0.05), respectively. The chi-square test values of the TEG R time with PT and APTT were 35.309 (P<0.001) and 15.848 (P<0.001), respectively. The Fibrinogen and the TEG K value, α-Angle, MA value had statistical significance (P<0.001), with a Kappa value of 0.323, 0.288 and 0.427, respectively. The chi-square test values between Fibrinogen and the TEG K value, α-Angle, MA value were not statistically significant, with X2=1.091 (P=0.296), X2=1.361 (P=0.243), X2=0.108 (P=0.742). The Kappa values of the platelet count and the TEG K value, α-Angle, MA value were 0.379, 0.208 and 0.352, respectively, which were also statistically significant difference (P<0.001). The chi-square test values between the platelet count and the TEG K value, α-Angle, MA value showed a statistically significant difference (P<0.001), with X2=37.5, X2=37.23, X2=26.630. The diagnostic sensitivity of the two methods for the patients with bleeding was less than 50%.
  
  
  CONCLUSIONS
  There was a significant correlation between some TEG parameters and routine coagulation tests, but the consistency is weak. Moreover, the diagnostic sensitivity of two methods in the patients with bleeding is low. It was concluded that the TEG cannot replace the conventional coagulation tests, and the preferable method remains uncertain which could reflect the risk of bleeding.
authors.affiliation: Department of Blood Transfusion, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.|Chinese PLA Medical College, Beijing 100853, China.
authors.forename: Guan-Yi
authors.initials: GY
authors.lastname: Chen
authors.affiliation: Department of Blood Transfusion, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China. E-mail: Ouy70301@yahoo.com.
authors.forename: Xi-Lin
authors.initials: XL
authors.lastname: Ou Yang
authors.affiliation: Department of Blood Transfusion, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Wu
authors.affiliation: Department of Blood Transfusion, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Wang
authors.affiliation: Department of Blood Transfusion, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Yang
authors.affiliation: Department of Blood Transfusion, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Li-Nan
authors.initials: LN
authors.lastname: Gu
authors.affiliation: Department of Blood Transfusion, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Zhu-Jie
authors.initials: ZJ
authors.lastname: Lu
authors.affiliation: Department of Blood Transfusion, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
authors.forename: Xiao-Zi
authors.initials: XZ
authors.lastname: Zhao
mesh_terms: D001777:Blood Coagulation; D005340:Fibrinogen; D006470:Hemorrhage; D006490:Hemostatics; D006801:Humans; D010976:Platelet Count; D012189:Retrospective Studies; D013916:Thrombelastography
chemical_list: D006490:Hemostatics; D005340:Fibrinogen