title: Effect of modification degree of nanohydroxyapatite on biocompatibility and mechanical property of injectable poly(methyl methacrylate)-based bone cement.
abstract: The objective of this study is to prepare a biocompatible nanohydroxyapatite/poly(methyl methacrylate) (HA/PMMA) composite bone cement, which has good mechanical property and can be used for vertebroplasty. Up to 40 wt % of nanohydroxyapatite (nano-HA) in the power, which was surface modified with poly(methylmethacrylate-co-γ-methacryloxypropyl timethoxysilane) [P(MMA-co-MPS)] copolymer, was incorporated into the composite bone cement. The content of P(MMA-co-MPS) on the surface of nano-HA (18.7%, 22.8%, and 26%) was determined through thermogravimetric analysis (TGA). The morphology of biomineralized surface of composite bone cement was observed under scanning electron microscope (SEM). The mechanical measurements of the composite cements implied that the interfacial interaction between the HA and PMMA matrix may be greatly enhanced after surface modification of HA. Biochemical assays indicated that the HA/PMMA bone cement had no cytotoxicity and induced no hemolysis. The cell adhesion and alkaline phosphatase (ALP) activity assays indicated that the biocompatibility of HA/PMMA bone cement could be promoted, demonstrating that it can be used as an ideal weight-bearing bone repair materials on clinical application.
authors.affiliation: School of Engineering, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.
authors.forename: Changyun
authors.identifier: http://orcid.org/0000-0001-9934-5348
authors.initials: C
authors.lastname: Quan
authors.affiliation: Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
authors.affiliation: School of Engineering, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Liu
authors.affiliation: School of Engineering, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.
authors.forename: Minyu
authors.initials: M
authors.lastname: Rao
authors.affiliation: Department of Outpatient, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510008, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Engineering, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.
authors.forename: Peiqing
authors.initials: P
authors.lastname: Liang
authors.affiliation: School of Engineering, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.affiliation: School of Engineering, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, People's Republic of China.
authors.forename: Huiyong
authors.initials: H
authors.lastname: Shen
authors.affiliation: School of Engineering, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiang
mesh_terms: D001843:Bone Cements / Q000737:chemistry / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D019904:Polymethyl Methacrylate / Q000737:chemistry / Q000494:pharmacology
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate; D017886:Durapatite
keywords: biocompatibility; mechanical property; modification degree; nanohydroxyapatite; poly(methyl methacrylate)