title: Results of sequential chemoradiotherapy for intracranial germinoma.
abstract: OBJECTIVE
  To evaluate the efficacy of sequential chemoradiotherapy (CRT) for intracranial germinoma by long-term follow-up.
  
  
  METHODS
  We retrospectively evaluated 23 consecutive intracranial germinoma patients without spinal dissemination, who had been treated by sequential CRT. All patients except for one were biopsied or surgically resected before treatment and all patients received both cranial and spinal magnetic resonance imaging. Three cycles of induction chemotherapy composed of etoposide and platinum agents were administered. The prescription of radiotherapy was 24 Gy per 12 fractions. No patients received spinal irradiation.
  
  
  RESULTS
  All patients accomplished CRT and achieved complete remission. No severe acute and late toxicities were observed. Median follow-up time was 11.8 years. The 5- and 10-year overall survival rates were 100 and 100 %, and relapse-free survival rates were 96 and 89 %, respectively. Three patients developed intracranial recurrence and all of them were successfully salvaged by additional CRT. All patients were alive without disease at final follow-up.
  
  
  CONCLUSIONS
  Treatment of 24 Gy of sequential CRT for intracranial germinoma might be promising as an alternative to radiotherapy alone. Spinal irradiation may not be necessary for patients who had no spinal dissemination and who were treated with CRT.
authors.affiliation: Department of Radiation Oncology, Hiroshima University Hospital, Kasumi 1-2-3, Minami-ku, Hiroshima, 734-8551, Japan, kenjom@hiroshima-u.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kenjo
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Yamasaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Takayasu
authors.forename: Ryo
authors.initials: R
authors.lastname: Nosaka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Murakami
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kimura
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Doi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Okabe
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nagata
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D018237:Germinoma / Q000628:therapy*; D006801:Humans; D008297:Male; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult