title: [(18)F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain.
abstract: The objective of this pilot study was to investigate central nervous system (CNS) changes related to osteoarthritis (OA)-associated chronic pain in cats using [(18)F]-fluorodeoxyglucose ((18)FDG) positron emission tomography (PET) imaging. The brains of five normal, healthy (non-OA) cats and seven cats with pain associated with naturally occurring OA were imaged using (18)FDG-PET during a standardized mild anesthesia protocol. The PET images were co-registered over a magnetic resonance image of a cat brain segmented into several regions of interest. Brain metabolism was assessed in these regions using standardized uptake values. The brain metabolism in the secondary somatosensory cortex, thalamus and periaqueductal gray matter was increased significantly (P ≤ 0.005) in OA cats compared with non-OA cats. This study indicates that (18)FDG-PET brain imaging in cats is feasible to investigate CNS changes related to chronic pain. The results also suggest that OA is associated with sustained nociceptive inputs and increased activity of the descending modulatory pathways.
authors.affiliation: Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
authors.forename: Martin
authors.initials: M
authors.lastname: Guillot
authors.affiliation: Laboratoire de recherche en imagerie et orthopédie (LIO), University of Montreal Hospital Research Centre (CRCHUM), École de Technologie Supérieure, Université du Québec, Montreal, QC, Canada.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Chartrand
authors.affiliation: Laboratoire de recherche en imagerie et orthopédie (LIO), University of Montreal Hospital Research Centre (CRCHUM), École de Technologie Supérieure, Université du Québec, Montreal, QC, Canada.
authors.forename: Ramnada
authors.initials: R
authors.lastname: Chav
authors.affiliation: Centre d'imagerie moléculaire de Sherbrooke (CIMS), Étienne-Le Bel Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada; Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Jacques
authors.initials: J
authors.lastname: Rousseau
authors.affiliation: Centre d'imagerie moléculaire de Sherbrooke (CIMS), Étienne-Le Bel Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Beaudoin
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
authors.forename: Johanne
authors.initials: J
authors.lastname: Martel-Pelletier
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pelletier
authors.affiliation: Centre d'imagerie moléculaire de Sherbrooke (CIMS), Étienne-Le Bel Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada; Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
authors.forename: Roger
authors.initials: R
authors.lastname: Lecomte
authors.affiliation: Laboratoire de recherche en imagerie et orthopédie (LIO), University of Montreal Hospital Research Centre (CRCHUM), École de Technologie Supérieure, Université du Québec, Montreal, QC, Canada.
authors.forename: Jacques A
authors.initials: JA
authors.lastname: de Guise
authors.affiliation: Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada. Electronic address: eric.troncy@umontreal.ca.
authors.forename: Eric
authors.initials: E
authors.lastname: Troncy
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D002415:Cats / Q000502:physiology*; D005240:Feasibility Studies; D019788:Fluorodeoxyglucose F18; D010003:Osteoarthritis / Q000150:complications / Q000662:veterinary*; D010146:Pain / Q000209:etiology / Q000662:veterinary*; D010865:Pilot Projects; D049268:Positron-Emission Tomography / Q000379:methods / Q000662:veterinary*
chemical_list: D019788:Fluorodeoxyglucose F18
keywords: Brain imaging; Cat; Central sensitization; Chronic pain; Osteoarthritis; Positron emission tomography