title: Application of high resolution synchrotron micro-CT radiation in dental implant osseointegration.
abstract: The purpose of this study was to describe a refined method using high-resolution synchrotron radiation microtomography (SRmicro-CT) to evaluate osseointegration and peri-implant bone volume fraction after titanium dental implant insertion. SRmicro-CT is considered gold standard evaluating bone microarchitecture. Its high resolution, high contrast, and excellent high signal-to-noise-ratio all contribute to the highest spatial resolutions achievable today. Using SRmicro-CT at a voxel size of 5 μm in an experimental goat mandible model, the peri-implant bone volume fraction was found to quickly increase to 50% as the radial distance from the implant surface increased, and levelled out to approximately 80% at a distance of 400 μm. This method has been successful in depicting the bone and cavities in three dimensions thereby enabling us to give a more precise answer to the fraction of the bone-to-implant contact compared to previous methods.
authors.affiliation: Research Center for Ageing and Osteoporosis, Departments of Diagnostics and Medicine, Copenhagen University Hospital Glostrup, Glostrup, Denmark; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address: camillaneldam@hotmail.com.
authors.forename: Camilla Albeck
authors.initials: CA
authors.lastname: Neldam
authors.affiliation: Nano Science Center, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Torsten
authors.initials: T
authors.lastname: Lauridsen
authors.affiliation: European Synchrotron Radiation Facility, Grenoble, France.
authors.forename: Alexander
authors.initials: A
authors.lastname: Rack
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital of Copenhagen (Rigshospitalet), Copenhagen, Denmark.
authors.forename: Tore Tranberg
authors.initials: TT
authors.lastname: Lefolii
authors.affiliation: Research Center for Ageing and Osteoporosis, Departments of Diagnostics and Medicine, Copenhagen University Hospital Glostrup, Glostrup, Denmark; Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Niklas Rye
authors.initials: NR
authors.lastname: Jørgensen
authors.affiliation: Nano Science Center, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Robert
authors.initials: R
authors.lastname: Feidenhans'l
authors.affiliation: Faculty of Health Sciences, Institute for Regional Health Sciences, University of Southern Denmark, Denmark.
authors.forename: Else Marie
authors.initials: EM
authors.lastname: Pinholt
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods; D000818:Animals; D016025:Bone Transplantation / Q000379:methods; D000069343:Bone-Implant Interface / Q000000981:diagnostic imaging; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry; D006041:Goats; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008334:Mandible / Q000000981:diagnostic imaging*; D008336:Mandibular Diseases / Q000601:surgery; D009929:Organ Size; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D011856:Radiographic Image Enhancement / Q000295:instrumentation / Q000379:methods; D059629:Signal-To-Noise Ratio; D017356:Synchrotrons; D014025:Titanium / Q000737:chemistry; D055114:X-Ray Microtomography / Q000295:instrumentation* / Q000379:methods
chemical_list: D015921:Dental Implants; D003764:Dental Materials; D014025:Titanium
keywords: Bone structure; Dental implants; Evaluation; High resolution; Osseointegration; Synchrotron radiation micro-CT