title: [Comparison of the Tumor-forming Rate between the SCID and NOD/SCID Mice used to Set up Acute Myeloid Leukemia Model].
abstract: OBJECTIVE
  To compare the tumor-forming rate between the SCID and NOD/SCID mice to set up acute myeloid leukemia (AML) mouse model.
  
  
  METHODS
  The SCID and NOD/SCID mice were injected with HL-60 cells in to the abdominal cavity in order to contruct the AML mouse model. The gereral status of mice was observed, the positive rate of CD33 in bone marrow cells was detected by flow cytometry, the mouse model was identified by pathologic examination.
  
  
  RESULTS
  The tumor-forming rate in constructed model using SCID mouse was 30%, while the tumor-forming rate in constructed model using NOD/SCID mouse was 100%.
  
  
  CONCLUSIONS
  Compared with SCID mice, the tumor-forming rate in NOD/SCID mice injected with HL-60 cells is high, the incidence of AML is stable, suggesting that the NOD/SCID mouse model is more suitable to explore the pathogenesis of leukemia.
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Liu
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Ze-Ping
authors.initials: ZP
authors.lastname: Zhou
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China. E-mail: youzhangmd@aliyun.am.
authors.forename: You
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005434:Flow Cytometry; D018922:HL-60 Cells; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID