title: Motor cortical plasticity induced by motor learning through mental practice.
abstract: Several investigations suggest that actual and mental actions trigger similar neural substrates. Motor learning via physical practice results in long-term potentiation (LTP)-like plasticity processes, namely potentiation of M1 and a temporary occlusion of additional LTP-like plasticity. However, whether this neuroplasticity process contributes to improve motor performance through mental practice remains to be determined. Here, we tested skill learning-dependent changes in primary motor cortex (M1) excitability and plasticity by means of transcranial magnetic stimulation (TMS) in subjects trained to physically execute or mentally perform a sequence of finger opposition movements. Before and after physical practice and motor-imagery practice, M1 excitability was evaluated by measuring the input-output (IO) curve of motor evoked potentials. M1 LTP and long-term depression (LTD)-like plasticity was assessed with paired-associative stimulation (PAS) of the median nerve and motor cortex using an interstimulus interval of 25 ms (PAS25) or 10 ms (PAS10), respectively. We found that even if after both practice sessions subjects significantly improved their movement speed, M1 excitability and plasticity were differentially influenced by the two practice sessions. First, we observed an increase in the slope of IO curve after physical but not after MI practice. Second, there was a reversal of the PAS25 effect from LTP-like plasticity to LTD-like plasticity following physical and MI practice. Third, LTD-like plasticity (PAS10 protocol) increased after physical practice, whilst it was occluded after MI practice. In conclusion, we demonstrated that MI practice lead to the development of neuroplasticity, as it affected the PAS25- and PAS10- induced plasticity in M1. These results, expanding the current knowledge on how MI training shapes M1 plasticity, might have a potential impact in rehabilitation.
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology, University of Genoa Genoa, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Avanzino
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology, University of Genoa Genoa, Italy ; Université de Bourgogne, Unité de Formation et de Recherche en Sciences et Techniques des Activités Physiques et Sportives Dijon, France ; Laboratoire Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 1093, Cognition, Action et Plasticité Sensorimotrice, Université de Bourgogne Dijon, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gueugneau
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology, University of Genoa Genoa, Italy.
authors.forename: Ambra
authors.initials: A
authors.lastname: Bisio
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology, University of Genoa Genoa, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Ruggeri
authors.affiliation: Université de Bourgogne, Unité de Formation et de Recherche en Sciences et Techniques des Activités Physiques et Sportives Dijon, France ; Laboratoire Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 1093, Cognition, Action et Plasticité Sensorimotrice, Université de Bourgogne Dijon, France.
authors.forename: Charalambos
authors.initials: C
authors.lastname: Papaxanthis
authors.affiliation: Department of Experimental Medicine, Section of Human Physiology, University of Genoa Genoa, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Bove
keywords: cortical plasticity; long term depression; long term potentiation; motor imagery; motor learning