title: Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain.
abstract: Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo1H magnetic resonance (MR) spectroscopy at 9.4 T. IUGR was induced via bilateral uterine artery ligation at gestational day 19 in pregnant Sprague-Dawley dams. MR spectra were obtained from the cerebral cortex, hippocampus and striatum at P7 in IUGR (N = 12) and NG (N = 13) rats. In the cortex, IUGR resulted in lower concentrations of phosphocreatine, glutathione, taurine, total choline, total creatine (P < 0.01) and [glutamate]/[glutamine] ratio (P < 0.05). Lower taurine concentrations were observed in the hippocampus (P < 0.01) and striatum (P < 0.05). IUGR differentially affects the neurochemical profile of the P7 rat brain regions. Persistent neurochemical changes may lead to cortex-based long-term neurodevelopmental deficits in human IUGR infants.
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Suite 13-227, MMC 391, Minneapolis, MN, 55455, USA. amalisze@umn.edu.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Maliszewski-Hall
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Suite 13-227, MMC 391, Minneapolis, MN, 55455, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Alexander
authors.affiliation: Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Tkáč
authors.affiliation: Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Gülin
authors.initials: G
authors.lastname: Öz
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Suite 13-227, MMC 391, Minneapolis, MN, 55455, USA.
authors.forename: Raghavendra
authors.initials: R
authors.lastname: Rao
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development* / Q000378:metabolism*; D001923:Brain Chemistry / Q000502:physiology*; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
keywords: Brain; IUGR; Magnetic resonance spectroscopy; Metabolism