title: Role of lamotrigine augmentation in treatment-resistant obsessive compulsive disorder: a retrospective case review from South Asia.
abstract: BACKGROUND
  Resistance to pharmacotherapy is one of the major challenges in the management of obsessive-compulsive disorder (OCD). OCD being a quite prevalent disorder, this resistance adds to the disability. Different strategies are being employed to counter this resistance, one of them being augmentation with glutamatergic modulators. Lamotrigine is being used for same since the recent past with mixed results.
  
  
  OBJECTIVE
  The aim was to study the role of lamotrigine augmentation in serotonin reuptake inhibitor (SRI) resistant OCD patients.
  
  
  RESULTS
  This study was carried by studying the case sheets of SRI resistant cases having already completed the treatment. A total of 22 cases sheets over 2 years met the study criteria with a mean age of mean age of 34.14 years. Over a period of 16 weeks, with a mean lamotrigine dose of 150 mg/day, 20 out of 22 patients had shown a significant response. The mean decrease in Yale-Brown Obsessive Compulsive Scale score was 67.23% with a baseline score of 28.87. There was a similar change on different domains of World Health Organization quality of life (P = 0.00564).
  
  
  CONCLUSIONS
  Lamotrigine augmentation to on-going treatment with SRIs may be an effective move in case of SRI resistant OCD patients.
authors.affiliation: Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Arshad
authors.initials: A
authors.lastname: Hussain
authors.affiliation: Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Mansoor Ahmad
authors.initials: MA
authors.lastname: Dar
authors.affiliation: Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Rayees Ahmad
authors.initials: RA
authors.lastname: Wani
authors.affiliation: Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Majid Shafi
authors.initials: MS
authors.lastname: Shah
authors.affiliation: Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Mohd Muzzaffar
authors.initials: MM
authors.lastname: Jan
authors.affiliation: Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Yasir A
authors.initials: YA
authors.lastname: Malik
authors.affiliation: Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Rajesh Kumar
authors.initials: RK
authors.lastname: Chandel
authors.affiliation: Department of Psychiatry, Government Medical College, Srinagar, Jammu and Kashmir, India.
authors.forename: Mushtaq Ahmad
authors.initials: MA
authors.lastname: Margoob
keywords: Augmentation; lamotrigine; obsessive-compulsive disorder; serotonin reuptake inhibitor resistance