title: Persistence of Neuropsychological Deficits Following Pediatric Critical Illness.
abstract: OBJECTIVE
  To study 12-month persistence of neuropsychological deficits in PICU survivors.
  
  
  METHODS
  Prospective follow-up study.
  
  
  METHODS
  Two PICUs.
  
  
  METHODS
  Children 5-16 years old with neuropsychological deficits 3-6 months following PICU care for meningoencephalitis, sepsis, and other critical illnesses (excluding other primary neurological disorders).
  
  
  METHODS
  None.
  
  
  RESULTS
  Neuropsychological function was assessed using the Cambridge Neuropsychological Test Automated Battery, the Children's Memory Scale, and the Wechsler Abbreviated Scale of Intelligence or Wide Range Intelligence Test. Forty-seven of 88 PICU admitted children (53%) were identified as neuropsychologically impaired 3-6 months after discharge; of these, 23 provided 12-month follow-up data. In spite of significant improvements in measures of memory, there was little change in intelligence quotient and visual attention over the study period, and children's educational progress remained below expectation.
  
  
  CONCLUSIONS
  We found persistently reduced neuropsychological function following PICU admission in the critical illnesses under study.
authors.affiliation: 1Centre for Mental Health, Department of Medicine, Imperial College London, London, United Kingdom. 2Department of Paediatric Intensive Care, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom. 3Department of Paediatric Intensive Care, Great Ormond Street Hospital, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
authors.forename: Lorraine C
authors.initials: LC
authors.lastname: Als
authors.forename: Anna
authors.initials: A
authors.lastname: Tennant
authors.forename: Simon
authors.initials: S
authors.lastname: Nadel
authors.forename: Mehrengise
authors.initials: M
authors.lastname: Cooper
authors.forename: Christine M
authors.initials: CM
authors.lastname: Pierce
authors.forename: M Elena
authors.initials: ME
authors.lastname: Garralda
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007360:Intelligence; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data*; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D017063:Outcome Assessment, Health Care / Q000706:statistics & numerical data*; D011446:Prospective Studies; D017741:Survivors