title: Can immunological principles and cross-disciplinary science illuminate the path to vaccines for HIV and other global health challenges?
abstract: Vaccines are one of the most impactful and cost-effective public health measures of the twentieth century. However, there remain great unmet needs to develop vaccines for globally burdensome infectious diseases and to allow more timely responses to emerging infectious disease threats. Recent advances in the understanding of immunological principles operative not just in model systems but in humans in concert with the development and application of powerful new tools for profiling human immune responses, in our understanding of pathogen variation and evolution, and in the elucidation of the structural aspects of antibody-pathogen interactions, have illuminated pathways by which these unmet needs might be addressed. Using these advances as foundation, we herein present a conceptual framework by which the discovery, development and iterative improvement of effective vaccines for HIV, malaria and other globally important infectious diseases might be accelerated.
authors.affiliation: Global Health Program, Bill & Melinda Gates Foundation, 500 Fifth Avenue North, Seattle, WA 98109, USA chris.wilson@gatesfoundation.org.
authors.forename: Christopher B
authors.identifier: http://orcid.org/0000-0002-8481-7629
authors.initials: CB
authors.lastname: Wilson
authors.affiliation: Global Health Program, Bill & Melinda Gates Foundation, 500 Fifth Avenue North, Seattle, WA 98109, USA.
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Karp
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D003140:Communicable Disease Control; D014943:Global Health; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans
chemical_list: D016915:AIDS Vaccines
keywords: HIV; antibody; avidity; immune; malaria; vaccine