title: An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15.
abstract: Chemokines and their receptors are essential regulators of in vivo leukocyte migration and, some years ago, a systematic nomenclature system was developed for the chemokine receptor family. Chemokine receptor biology and biochemistry was recently extensively reviewed. In this review, we also highlighted a new component to the nomenclature system that incorporates receptors previously known as 'scavenging', or 'decoy', chemokine receptors on the basis of their lack of classical signalling responses to ligand binding and their general ability to scavenge, or sequester, their cognate chemokine ligands. These molecules are now collectively referred to as 'atypical chemokine receptors', or ACKRs, and play fundamental roles in regulating in vivo responses to chemokines. This commentary highlights this new addition to the chemokine receptor nomenclature system and provides brief information on the four receptors currently covered by this nomenclature.
authors.affiliation: INSERM UMR-S996, Laboratory of Excellence in Research on Medication and Innovative Therapeutics, Université Paris-Sud, Clamart, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Bachelerie
authors.affiliation: Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK.
authors.forename: Gerard J
authors.initials: GJ
authors.lastname: Graham
authors.affiliation: Department of Molecular Biotechnology and Translational Medicine, University of Milan, Milan, Italy.|Istituto Clinico Humanitas, Humanitas University, Rozzano, Milano, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Locati
authors.affiliation: Department of Molecular Biotechnology and Translational Medicine, University of Milan, Milan, Italy.|Istituto Clinico Humanitas, Humanitas University, Rozzano, Milano, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.affiliation: Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Philip M
authors.initials: PM
authors.lastname: Murphy
authors.affiliation: Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Nibbs
authors.affiliation: Medical Research Council Centre for Immune Regulation, Institute of Biomedical Research, School of Infection and Immunity, University of Birmingham, Birmingham, UK.
authors.forename: Antal
authors.initials: A
authors.lastname: Rot
authors.affiliation: Istituto Clinico Humanitas, Humanitas University, Rozzano, Milano, Italy.|Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
authors.forename: Silvano
authors.initials: S
authors.lastname: Sozzani
authors.affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland.
authors.forename: Marcus
authors.initials: M
authors.lastname: Thelen
mesh_terms: D000818:Animals; D006801:Humans; D019707:Receptors, Chemokine / Q000145:classification* / Q000378:metabolism; D009626:Terminology as Topic
chemical_list: D019707:Receptors, Chemokine