title: Association of platelet activation markers with cancer-associated venous thromboembolism.
abstract: Venous thromboembolism (VTE) is a frequent complication in cancer patients. Platelet activation is thought to be involved in cancer-associated VTE. Here, we determined the association between evolving markers of platelet activation (soluble P-selectin [sP-selectin], soluble CD40 ligand [sCD40L], thrombospondin-1 [TSP-1] and platelet factor-4 [PF-4]) and the development of cancer-associated VTE. A nested matched case-control study was applied within a cohort of 1779 patients with different types of cancer that had been included in the Vienna Cancer and Thrombosis Study (CATS), a prospective, observational study on patients with newly diagnosed or progressive cancer after remission. Primary endpoint is symptomatic VTE during a maximum follow-up of 2 years. Cases (patients who developed VTE during follow-up) were matched in a 1:2 ratio to controls without VTE during follow-up with respect to tumor type, stage and time of observation in the study. In total, 131 VTE cases were compared to 262 controls. In logistic regression analysis, only sP-selectin was associated with risk of VTE. The odds ratios (OR) per double increase of sP-selectin, sCD40L, TSP-1 and PF-4 were 1.66 (95% confidence interval: 1.17-2.35, p = 0.005), 1.04 (0.89-1.21, p = 0.635), 1.09 (0.90-1.32, p = 0.360) and 1.03 (0.87-1.21, p = 0.737), respectively. In conclusion, sP-selectin, but not sCD40L, TSP-1 or PF-4 were associated with risk of VTE in cancer patients in this nested case-control study.
authors.affiliation: a Clinical Division of Haematology and Haemostaseology, Department of Medicine I , Comprehensive Cancer Center Vienna, Medical University of Vienna , Vienna , Austria .
authors.forename: Julia
authors.initials: J
authors.lastname: Riedl
authors.affiliation: a Clinical Division of Haematology and Haemostaseology, Department of Medicine I , Comprehensive Cancer Center Vienna, Medical University of Vienna , Vienna , Austria .
authors.forename: Lena
authors.initials: L
authors.lastname: Hell
authors.affiliation: b Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna , Vienna , Austria .
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kaider
authors.affiliation: a Clinical Division of Haematology and Haemostaseology, Department of Medicine I , Comprehensive Cancer Center Vienna, Medical University of Vienna , Vienna , Austria .
authors.forename: Silvia
authors.initials: S
authors.lastname: Koder
authors.affiliation: c Clinical Division of Oncology, Department of Medicine I , Comprehensive Cancer Center Vienna, Medical University of Vienna , Vienna , Austria , and.
authors.forename: Christine
authors.initials: C
authors.lastname: Marosi
authors.affiliation: c Clinical Division of Oncology, Department of Medicine I , Comprehensive Cancer Center Vienna, Medical University of Vienna , Vienna , Austria , and.
authors.forename: Christoph
authors.initials: C
authors.lastname: Zielinski
authors.affiliation: d Department of Blood Group Serology and Transfusion Medicine , Medical University of Vienna , Vienna , Austria.
authors.forename: Simon
authors.initials: S
authors.lastname: Panzer
authors.affiliation: a Clinical Division of Haematology and Haemostaseology, Department of Medicine I , Comprehensive Cancer Center Vienna, Medical University of Vienna , Vienna , Austria .
authors.forename: Ingrid
authors.initials: I
authors.lastname: Pabinger
authors.affiliation: a Clinical Division of Haematology and Haemostaseology, Department of Medicine I , Comprehensive Cancer Center Vienna, Medical University of Vienna , Vienna , Austria .
authors.forename: Cihan
authors.initials: C
authors.lastname: Ay
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000473:pathology; D015539:Platelet Activation; D011446:Prospective Studies; D012307:Risk Factors; D054556:Venous Thromboembolism / Q000097:blood* / Q000473:pathology
keywords: Cancer; platelet activation; platelets; risk prediction; venous thromboembolism