title: Role of citrate and other methods of anticoagulation in patients with severe liver failure requiring continuous renal replacement therapy.
abstract: Anticoagulation is required during continuous renal replacement therapy to prevent filter clotting and optimize filter performance. However, anticoagulation may also be associated with serious bleeding complications. Patients with liver failure often suffer from underlying coagulopathy and are especially prone to anticoagulation complications. The aim of this review is to present the unique features of patients with hepatic injury in terms of anticoagulation disorders and to analyze data on safety and efficacy of the different anticoagulation methods for liver failure patients undergoing continuous renal replacement therapy.
authors.affiliation: Division of Nephrology, Department of Medicine, Hôpital du Sacré-Coeur de Montréal , Université de Montréal , Montreal, Quebec , Canada.
authors.forename: Josée
authors.initials: J
authors.lastname: Bouchard
authors.affiliation: Division of Nephrology, Department of Medicine, Hôpital du Sacré-Coeur de Montréal , Université de Montréal , Montreal, Quebec , Canada.
authors.forename: François
authors.initials: F
authors.lastname: Madore
keywords: anticoagulation; citrate; continuous renal replacement therapy; liver failure