title: Oral squamous cell carcinoma arising in a patient after hematopoietic stem cell transplantation with bisphosphonate-related osteonecrosis of the jaws.
abstract: A 55-year-old man with a history of acute myeloid leukaemia treated with hematopoietic stem cell transplantation and with a 5-year history of bisphosphonate-related osteonecrosis of the jaws, following 12 cycles of intravenous zoledronic acid therapy, presented in December 2009 with a history of increasingly severe unilateral lower jaw pain. Oral examination revealed, as previously, exposed bone in the left mandible, but also a new exophytic mass on the lower-left buccal mucosa. Biopsy confirmed a diagnosis of oral squamous cell carcinoma. To the best of our knowledge, this is the first report of an oral squamous cell carcinoma that appeared adjacent to an area of osteochemonecrosis.
authors.affiliation: Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy.
authors.forename: Paolo G
authors.identifier: 0000-0002-8798-7834
authors.initials: PG
authors.lastname: Arduino
authors.affiliation: WHO Collaborating Centre for Oral Health-General Health, UK ; University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Crispian
authors.initials: C
authors.lastname: Scully
authors.affiliation: Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Corso Bramante 88, 10126 Turin, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Chiusa
authors.affiliation: Department of Surgical Sciences, Oral Medicine Section, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Broccoletti