title: The Effect of Viola odorata Flower Syrup on the Cough of Children With Asthma: A Double-Blind, Randomized Controlled Trial.
abstract: This study aimed to investigate the effect of violet syrup on cough alleviation in children with intermittent asthma. In a parallel, double-blind, randomized controlled trial, 182 children aged 2 to 12 years with intermittent asthma were randomly assigned 1:1 to receive violet syrup or placebo along with the common standard treatments in both groups (short-acting β-agonist). Both groups were evaluated in terms of the duration until cough suppression was achieved. No significant difference was observed in basic characteristics. The duration lasting to yield more than 50% cough reduction and 100% cough suppression was significantly less in the violet syrup group compared to placebo (P = .001, P < .001, respectively). There was no significant difference in therapeutic effects between boys and girls. There was a significant inverse correlation between the age of children and rate of cough alleviation and suppression by violet syrup. This study showed that the adjuvant use of violet syrup with short-acting β-agonist can enhance the cough suppression in children with intermittent asthma.
authors.affiliation: Department of Medicine, Qom Branch, Islamic Azad University, Qom, Iran.
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Qasemzadeh
authors.affiliation: Persian Medicine & Pharmacy Research Center, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran hoseinsharifi50@yahoo.com.
authors.forename: Hosein
authors.initials: H
authors.lastname: Sharifi
authors.affiliation: Department of Medicine, Qom Branch, Islamic Azad University, Qom, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hamedanian
authors.affiliation: Department of Medicine, Qom Branch, Islamic Azad University, Qom, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Gharehbeglou
authors.affiliation: Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Heydari
authors.affiliation: Persian Medicine & Pharmacy Research Center, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Sardari
authors.affiliation: Minimally Invasive Techniques Research Center of Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Meisam
authors.initials: M
authors.lastname: Akhlaghdoust
authors.affiliation: Persian Medicine & Pharmacy Research Center, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Bagher
authors.initials: MB
authors.lastname: Minae
mesh_terms: D001249:Asthma / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D003371:Cough / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D035264:Flowers / Q000737:chemistry; D006801:Humans; D008297:Male; D032413:Viola / Q000737:chemistry*
keywords: Viola odorata; asthma; children; cough; herbal medicine; traditional persian medicine