title: The MEME Suite.
abstract: The MEME Suite is a powerful, integrated set of web-based tools for studying sequence motifs in proteins, DNA and RNA. Such motifs encode many biological functions, and their detection and characterization is important in the study of molecular interactions in the cell, including the regulation of gene expression. Since the previous description of the MEME Suite in the 2009 Nucleic Acids Research Web Server Issue, we have added six new tools. Here we describe the capabilities of all the tools within the suite, give advice on their best use and provide several case studies to illustrate how to combine the results of various MEME Suite tools for successful motif-based analyses. The MEME Suite is freely available for academic use at http://meme-suite.org, and source code is also available for download and local installation.
authors.affiliation: Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Queensland, Australia t.bailey@uq.edu.au.
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Bailey
authors.affiliation: Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Queensland, Australia.
authors.forename: James
authors.initials: J
authors.lastname: Johnson
authors.affiliation: Department of Genome Sciences, Department of Computer Science and Engineering, University of Washington, Seattle, WA 98109, USA.
authors.forename: Charles E
authors.initials: CE
authors.lastname: Grant
authors.affiliation: Department of Genome Sciences, Department of Computer Science and Engineering, University of Washington, Seattle, WA 98109, USA william-noble@uw.edu.
authors.forename: William S
authors.initials: WS
authors.lastname: Noble
mesh_terms: D020816:Amino Acid Motifs; D004247:DNA / Q000737:chemistry; D020407:Internet; D059372:Nucleotide Motifs; D010963:Plasmodium falciparum; D054730:Protein Interaction Domains and Motifs; D021382:Protein Sorting Signals; D015800:Protozoan Proteins / Q000737:chemistry; D018167:Receptors, Calcitriol / Q000737:chemistry; D017422:Sequence Analysis, DNA; D020539:Sequence Analysis, Protein; D017423:Sequence Analysis, RNA; D012984:Software
chemical_list: D021382:Protein Sorting Signals; D015800:Protozoan Proteins; D018167:Receptors, Calcitriol; D004247:DNA