title: Imaging features of primary and recurrent intrathoracic synovial sarcoma: a single-institute experience.
abstract: OBJECTIVE
  The objective was to study the imaging features of primary and metastatic intrathoracic synovial sarcoma (ISS).
  
  
  METHODS
  We reviewed the imaging of 42 patients with ISS (31 pleural, 7 intrapulmonary, 4 mediastinal), with baseline imaging of 19 patients and follow-up imaging in all.
  
  
  RESULTS
  Primary tumors (n=19) were well circumscribed (15/19), homogeneous or heterogeneously enhancing, with mean size 9.1 cm (range: 1.8-25 cm). Recurrent/metastatic disease developed in 28/42 patients (67%). Lung was the most common site of metastases (21/28), with most of them predominantly pleural (11/21). On pathology, 30 patients had monophasic tumors, and 6 each had biphasic tumors and poorly differentiated tumors.
  
  
  CONCLUSIONS
  Intrathoracic SS most commonly presents as a large heterogeneous pleural mass without associated adenopathy. Lung metastases are often pleural based and ipsilateral.
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115. Electronic address: akshaybaheti@gmail.com.
authors.forename: Akshay D
authors.initials: AD
authors.lastname: Baheti
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115.
authors.forename: Rani
authors.initials: R
authors.lastname: Sewatkar
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115.
authors.forename: Jason L
authors.initials: JL
authors.lastname: Hornick
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX.
authors.forename: Sachin S
authors.initials: SS
authors.lastname: Saboo
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115.
authors.forename: Jyothi P
authors.initials: JP
authors.lastname: Jagannathan
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115.
authors.forename: Nikhil H
authors.initials: NH
authors.lastname: Ramaiya
authors.affiliation: Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA 02215; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115.
authors.forename: Sree Harsha
authors.initials: SH
authors.lastname: Tirumani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010997:Pleural Neoplasms / Q000556:secondary; D012189:Retrospective Studies; D013584:Sarcoma, Synovial / Q000473:pathology* / Q000556:secondary; D013899:Thoracic Neoplasms / Q000473:pathology* / Q000556:secondary; D055815:Young Adult
keywords: Intrathoracic; Pleural; Pulmonary; Synovial sarcoma