title: Synthesis of the nakanishi ring-locked retinoid.
abstract: An optimized synthetic route to prepare ring-locked retinoid 1a has been developed. We fully describe a purification protocol that provides isomerically pure 1a in support of on-going proof of concept studies for the development of therapeutic agents to treat human ADRP. Additionally, we have found that isomerically pure 1a can be stored in amber vials under argon at -20°C for use over time (up to six months) without degradation. Thus, enabling 1a to be an accessible and valuable biological tool.
authors.affiliation: Dalton Medicinal Chemistry Inc., 349 Wildcat Road, Toronto, ON, Canada M3J 2S3.
authors.forename: Jamie B
authors.initials: JB
authors.lastname: Côté
authors.affiliation: Dalton Medicinal Chemistry Inc., 349 Wildcat Road, Toronto, ON, Canada M3J 2S3.
authors.forename: Tan D
authors.initials: TD
authors.lastname: Quach
authors.affiliation: Dalton Pharma Services, 349 Wildcat Road, Toronto, ON, Canada M3J 2S3.
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Demenev
authors.affiliation: Bikam Pharmaceuticals Inc., c/o Fidelity Biosciences, 1 Main Street, 13th Floor, Cambridge, MA 02142, USA.
authors.forename: David S
authors.initials: DS
authors.lastname: Garvey
authors.affiliation: Dalton Medicinal Chemistry Inc., 349 Wildcat Road, Toronto, ON, Canada M3J 2S3.
authors.forename: Judd M
authors.initials: JM
authors.lastname: Berman