title: Deproteinized bovine bone in association with guided tissue regeneration or enamel matrix derivatives procedures in aggressive periodontitis patients: a 1-year retrospective study.
abstract: OBJECTIVE
  To retrospectively evaluate and compare two regenerative periodontal procedures in young individuals with aggressive periodontitis (AgP).
  
  
  METHODS
  Thirty-two patients aged 14-25 years (mean ± SD 19.3 ± 5.7) were diagnosed as having AgP with multiple intra-bony defects (IBDs) and treated by one of two regenerative modalities of periodontal therapy: guided tissue regeneration (GTR) using deproteinized bone xenograft (DBX) particles and a resorbable membrane (the GTR group), or an application of enamel matrix derivatives (EMD) combined with DBX (the EMD/DBX group). Periodic monitoring of treated sites included recording of probing depth (PD), clinical attachment level (CAL) and gingival recession. Pre-treatment and 1-year post-operative findings were statistically analysed within and between groups.
  
  
  RESULTS
  The PD and CAL values decreased significantly with time, but not those between study groups. The mean pre-treatment and 1-year post-treatment PDs of the IBDs of the GTR group (n = 16; sites = 67) were 8.93 ± 1.14 mm and 3.58 ± 0.50 mm, respectively, and the mean CALs were 9.03 ± 1.03 mm and 4.16 ± 0.53 mm respectively. The mean PDs of the EMD/DBX group (n = 16; sites = 73) were 8.77 ± 1.04 mm and 3.61 ± 0.36 mm, respectively, and the mean CALS were 8.79 ± 1.04 mm and 3.77 ± 0.22 mm respectively (p < 0.001 for all).
  
  
  CONCLUSIONS
  Surgical treatment of AgP patients by either GTR or by application of EMD/DBX yielded similarly successful clinical results at 1-year post-treatment.
authors.affiliation: Department of Periodontology and Oral Implants, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Zvi
authors.initials: Z
authors.lastname: Artzi
authors.affiliation: Department of Periodontology and Oral Implants, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Haim
authors.initials: H
authors.lastname: Tal
authors.affiliation: Department of Periodontology and Oral Implants, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ori
authors.initials: O
authors.lastname: Platner
authors.affiliation: Department of Periodontology and Oral Implants, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Nadav
authors.initials: N
authors.lastname: Wasersprung
authors.affiliation: Department of Periodontology and Oral Implants, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Evgeny
authors.initials: E
authors.lastname: Weinberg
authors.affiliation: Department of Periodontology and Oral Implants, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Shimshon
authors.initials: S
authors.lastname: Slutzkey
authors.affiliation: Currently in Private Practice, Herzliya, Israel.
authors.forename: Nir
authors.initials: N
authors.lastname: Gozali
authors.affiliation: Currently in Private Practice, Haifa, Israel.
authors.forename: Guy
authors.initials: G
authors.lastname: Carmeli
authors.affiliation: Currently in Private Practice, Tel Aviv, Israel.
authors.forename: Ran
authors.initials: R
authors.lastname: Herzberg
authors.affiliation: Department of Periodontology and Oral Implants, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Avital
authors.initials: A
authors.lastname: Kozlovsky
mesh_terms: D020341:Absorbable Implants; D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000188:drug therapy / Q000601:surgery*; D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000601:surgery; D000818:Animals; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D015331:Cohort Studies; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000188:drug therapy / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D064593:Heterografts / Q000637:transplantation*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000601:surgery; D010514:Periodontal Pocket / Q000188:drug therapy / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003746:Dental Enamel Proteins; D008567:Membranes, Artificial; C109069:enamel matrix proteins
keywords: Aggressive periodontitis; deproteinized bovine bone (Bio-Oss®); enamel matrix derivatives (Emdogain®); guided tissue regeneration; periodontal regeneration