title: Dual-Responsive pH and Temperature Sensitive Nanoparticles Based on Methacrylic Acid and Di(ethylene glycol) Methyl Ether Methacrylate for the Triggered Release of Drugs.
abstract: A series of thermo-and pH-responsive poly(methyl methacrylate)-block-poly[methacrylic acid-co-di(ethylene glycol) methyl ether methacrylate] PMMA-b-P[MAA-co-DEGMA] block copolymers were synthesized by RAFT polymerization and self-assembled into micelles. The molar ratio of MAA was altered from 0-12% in order to modulate the lower critical solution temperature (LCST) of PDEGMA. The release of the drug albendazole from the micelle was strongly dependent on the temperature and the LCST value of the polymer. Systems below the LCST released the drug slowly while increasing the temperature above the LCST or decreasing the pH value to 5 resulted in the burst-like release of the drug. ABZ delivered in this pH-responsive drug carrier had a higher toxicity than the free drug or the drug delivered in a non-responsive drug carrier.
authors.affiliation: Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Yee Yee
authors.initials: YY
authors.lastname: Khine
authors.affiliation: Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.|Department of Pharmaceutical Chemistry, Faculty of Pharmacy, BezmialemVakif University, 34093 Fatih, Istanbul, Turkey.
authors.forename: Aydan
authors.initials: A
authors.lastname: Dag
authors.affiliation: Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Hongxu
authors.initials: H
authors.lastname: Lu
authors.affiliation: Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia. M.Stenzel@unsw.edu.au.
authors.forename: Martina H
authors.initials: MH
authors.lastname: Stenzel
mesh_terms: D015766:Albendazole / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006801:Humans; D006863:Hydrogen-Ion Concentration; D020366:Methylmethacrylate / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D011109:Polymethacrylic Acids; D020366:Methylmethacrylate; C038300:methylmethacrylate-methacrylic acid copolymer; D015766:Albendazole
keywords: dual-responsive; lower critical solution temperature (LCST); micelle; pH-responsive