title: Chromatin plasticity in response to DNA damage: The shape of things to come.
abstract: DNA damage poses a major threat to cell function and viability by compromising both genome and epigenome integrity. The DNA damage response indeed operates in the context of chromatin and relies on dynamic changes in chromatin organization. Here, we review the molecular bases of chromatin alterations in response to DNA damage, focusing on core histone mobilization in mammalian cells. Building on our current view of nucleosome dynamics in response to DNA damage, we highlight open challenges and avenues for future development. In particular, we discuss the different levels of regulation of chromatin plasticity during the DNA damage response and their potential impact on cell function and epigenome maintenance.
authors.affiliation: Epigenome Integrity Group, UMR 7216 CNRS/Paris Diderot University, 35 rue Helene Brion, 75013 Paris, France; Chromatin Dynamics Group, UMR 3664 CNRS/Institut Curie Research Center, 26 rue d'Ulm 75005 Paris, France.
authors.forename: Salomé
authors.initials: S
authors.lastname: Adam
authors.affiliation: Epigenome Integrity Group, UMR 7216 CNRS/Paris Diderot University, 35 rue Helene Brion, 75013 Paris, France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Dabin
authors.affiliation: Epigenome Integrity Group, UMR 7216 CNRS/Paris Diderot University, 35 rue Helene Brion, 75013 Paris, France. Electronic address: sophie.polo@univ-paris-diderot.fr.
authors.forename: Sophie E
authors.initials: SE
authors.lastname: Polo
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D042002:Chromatin Assembly and Disassembly; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D044127:Epigenesis, Genetic; D006657:Histones / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D009707:Nucleosomes / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D006657:Histones; D018832:Molecular Chaperones; D009707:Nucleosomes; D004247:DNA
keywords: Chromatin dynamics; Chromatin remodelers; DNA damage repair; Epigenome maintenance; Histone chaperones; Histone variants