title: Treatment of sarcoid granulomatous interstitial nephritis with adalimumab.
abstract: Sarcoidosis is a systemic disease with multiorgan involvement which can cause renal failure through several different mechanisms. Granulomatous interstitial nephritis is an important albeit less frequent cause of clinically significant renal disease. Herein, we present the case of a 46 year old woman with a history of sarcoidosis whom we evaluated for rapidly worsening kidney function and proteinuria. Renal biopsy revealed granulomatous interstitial nephritis. After therapy with adalimumab, her renal function improved with a significant reduction in proteinuria. Repeat kidney biopsy showed resolution of renal granulomata. To our knowledge, this is the first report of successful treatment of granulomatous interstitial nephritis with adalimumab.
authors.affiliation: Department of Nephrology.
authors.forename: Roopali
authors.initials: R
authors.lastname: Gupta
authors.affiliation: Department of Pathology, Washington Hospital Center, Washington, DC , USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Beaudet
authors.affiliation: Department of Nephrology.
authors.forename: Jack
authors.initials: J
authors.lastname: Moore
authors.affiliation: Department of Nephrology.
authors.forename: Tulsi
authors.initials: T
authors.lastname: Mehta
keywords: TNF-alpha inhibitors; adalimumab; granulomatous interstitial nephritis; sarcoidosis