title: Compactible powders of omega-3 and β-cyclodextrin.
abstract: Omega-3 fatty acids are used in both nutraceuticals and pharmaceuticals in the form of triglycerides and ethyl esters. Administration forms available for omega-3 include bulk oil, soft gel capsules, emulsions and some powder compositions. Cyclodextrins are substances well known for their ability to encapsulate lipophilic molecules. In the present work, powders loaded with omega-3 oil, ranging from 10 to 40% (w/w), have been prepared by vacuum drying, freeze drying or spray granulation of aqueous mixtures of omega-3 oil and β-cyclodextrin. The powders were found to be partially crystalline by powder X-ray diffraction and to contain crystalline phases not present in pure β-cyclodextrin, indicating true complexation. The compactibility of the powders has been explored, revealing that a dry and compactible powder can be prepared from various omega-3 oils and β-cyclodextrin. Spray granulation was found to be the superior drying method for the preparation of compactible powders.
authors.affiliation: Omegatri AS, P.O. Box 4849 Nydalen, 0422 Oslo, Norway; School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway. Electronic address: tina.lien.vestland@omegatri.no.
authors.forename: Tina Lien
authors.initials: TL
authors.lastname: Vestland
authors.affiliation: Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, 0315 Oslo, Norway.
authors.forename: Øyvind
authors.initials: Ø
authors.lastname: Jacobsen
authors.affiliation: School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
authors.forename: Sverre Arne
authors.initials: SA
authors.lastname: Sande
authors.affiliation: Tåsen Terrasse 4A, 0873 Oslo, Norway.
authors.forename: Astrid Hilde
authors.initials: AH
authors.lastname: Myrset
authors.affiliation: Omegatri AS, P.O. Box 4849 Nydalen, 0422 Oslo, Norway; School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
authors.forename: Jo
authors.initials: J
authors.lastname: Klaveness
mesh_terms: D003890:Desiccation; D004339:Drug Compounding; D015525:Fatty Acids, Omega-3 / Q000737:chemistry*; D005511:Food Handling; D005612:Freeze Drying; D011208:Powders / Q000737:chemistry; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D015525:Fatty Acids, Omega-3; D011208:Powders; D047392:beta-Cyclodextrins; C031215:betadex
keywords: Cyclodextrin; DHA; EPA; Fish oil; Omega-3; Powder; Tablets