title: Predictors of adherence to treatment in bronchiectasis.
abstract: OBJECTIVE
  We aimed to determine if beliefs about treatment, clinical factors and quality of life predicted adherence to treatment in patients with bronchiectasis.
  
  
  METHODS
  We recruited participants with confirmed bronchiectasis to a one-year study. We calculated adherence to treatment using medication possession ratios and self-report. Baseline Beliefs about Medicines, clinical, demographic and Quality of Life Questionnaire-Bronchiectasis data were collected. We used logistic regression to determine predictors of adherence to treatment during the subsequent year.
  
  
  RESULTS
  Seventy-five participants were recruited. Beliefs about harm, age and total number of prescribed medications were predictors of adherence to inhaled antibiotics. Concerns about medication, age and Quality of Life Questionnaire-Bronchiectasis Treatment Burden were predictors of adherence to other respiratory medicines. Beliefs about necessity of airway clearance and age were predictors of adherence to airway clearance.
  
  
  CONCLUSIONS
  Beliefs about treatment, age, number of prescribed medications and perceived treatment burden predicted subsequent adherence in bronchiectasis, thereby, providing potential targets for future interventions in this population. Clinicians can use these data to identify patients with bronchiectasis who might be at risk of non-adherence i.e. those who are younger, have concerns about medications, who do not think airway clearance is necessary or who are prescribed numerous medications.
authors.affiliation: Clinical and Practice Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK. Electronic address: amanda.mccullough@qub.ac.uk.
authors.forename: Amanda R
authors.initials: AR
authors.lastname: McCullough
authors.affiliation: Clinical and Practice Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK. Electronic address: michael.tunney@qub.ac.uk.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Tunney
authors.affiliation: Center for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK. Electronic address: s.elborn@qub.ac.uk.
authors.forename: J
authors.initials: J
authors.lastname: Stuart Elborn
authors.affiliation: Center for Health and Rehabilitation Technologies (CHaRT), Institute of Nursing and Health Research, University of Ulster, Jordanstown, UK. Electronic address: jm.bradley@ulster.ac.uk.
authors.forename: Judy M
authors.initials: JM
authors.lastname: Bradley
authors.affiliation: Clinical and Practice Research Group, School of Pharmacy, Queen's University Belfast, Belfast, UK. Electronic address: c.hughes@qub.ac.uk.
authors.forename: Carmel M
authors.initials: CM
authors.lastname: Hughes
mesh_terms: D000280:Administration, Inhalation; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001987:Bronchiectasis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D000900:Anti-Bacterial Agents
keywords: Beliefs about medicines questionnaire; Bronchiectasis; Patient compliance (medication adherence); Quality of life questionnaire-bronchiectasis