title: inv (4)(p13q13) in patient with essential thrombocythemia: A case report.
abstract: The inv (4)(p13q13) cytogenetic abnormality is uncommon in hematologic malignancies. So far, it has not been previously reported in patients with essential thrombocythemia (ET). We report a first case of ET with inv (4)(p13q13) karyotype in a 69-year-old female patient who developed myelofibrosis at follow up. Conventional cytogenetic analysis from a bone marrow sample showed 46, XX, inv (4)(p13q13) [3]/46, XX [4] at diagnosis and subsequent analysis revealed the same abnormal karyotype during the myelofibrosis phase (46, XX, inv (4)(p13q13) [13]/46, XX [26]). The prognostic significance of this chromosomal abnormality is unknown.
authors.affiliation: Mehmet Akif Ersoy University, Bucak School of Health, Department of Nursing, Burdur, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Aydin
authors.affiliation: Akdeniz University, Faculty of Medicine, Department of Hematology, Antalya, Turkey.
authors.forename: Ozan
authors.initials: O
authors.lastname: Salim
authors.affiliation: Akdeniz University, Faculty of Medicine, Department of Hematology, Antalya, Turkey.
authors.forename: Orhan Kemal
authors.initials: OK
authors.lastname: Yucel
authors.affiliation: Akdeniz University, Faculty of Medicine, Department of Hematology, Antalya, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Undar
authors.affiliation: Akdeniz University, Faculty of Medicine, Department of Medical Biology and Genetics, Antalya, Turkey. Electronic address: sibelberker@akdeniz.edu.tr.
authors.forename: Sibel Berker
authors.initials: SB
authors.lastname: Karauzum
mesh_terms: D000368:Aged; D001854:Bone Marrow Cells / Q000473:pathology; D007446:Chromosome Inversion; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D013920:Thrombocythemia, Essential / Q000235:genetics*
keywords: Essential thrombocythemia; Myeloproliferative disorder; inv (4)(p13q13)