title: Anti-oxidant capacity and anti-tumor T cell function: A direct correlation.
abstract: Improving persistence and sustained function of effector CD8+T cell response is key for achieving significant tumor control in adoptive T cell immunotherapy protocols. Our recent report shows that high anti-oxidant property is central to potent anti-tumor effector T cells, and directly correlates to CD62Lhicentral memory, low glycolytic and low mitochondrial membrane potential phenotype, all of which may be linked and contribute to better tumor control.
authors.affiliation: Department of Surgery; Medical University of South Carolina ; Charleston, SC USA.
authors.forename: Pravin
authors.initials: P
authors.lastname: Kesarwani
authors.affiliation: Department of Surgery; Medical University of South Carolina ; Charleston, SC USA.
authors.forename: Krishnamurthy
authors.initials: K
authors.lastname: Thyagarajan
authors.affiliation: Department of Surgery; Medical University of South Carolina ; Charleston, SC USA.
authors.forename: Shilpak
authors.initials: S
authors.lastname: Chatterjee
authors.affiliation: Oral Health Sciences; Medical University of South Carolina ; Charleston, SC USA.
authors.forename: Viswanathan
authors.initials: V
authors.lastname: Palanisamy
authors.affiliation: Department of Surgery; Medical University of South Carolina ; Charleston, SC USA.
authors.forename: Shikhar
authors.initials: S
authors.lastname: Mehrotra
keywords: adoptive immunotherapy, melanoma, Thiols, T cell