title: Pediatric cancer epigenome and the influence of folate.
abstract: Despite improvement in clinical treatment of childhood cancer, it remains the leading cause of disease-related mortality in children with survivors often suffering from treatment-related toxicity and premature death. Because childhood cancer is vastly different from cancer in adults, a thorough understanding of the underlying molecular mechanisms specific to childhood cancer is essential. Although childhood cancer contains much fewer mutations, a subset of cancer subtypes has a higher frequency of mutations in gene encoding epigenetic regulators. Thus, in this review, we will focus on epigenetic deregulations in childhood cancers, the use of genome-wide analysis for cancer subtype classification, prediction of clinical outcomes and the influence of folate on epigenetic mechanisms.
authors.affiliation: Department of Pediatrics, Texas Children's Cancer Center, 6701 Fannin St, Ste 1400, Houston, TX 77030, USA.|Dan L Duncan Cancer Center, 1 Baylor Plaza 450A, Houston, TX 77030, USA.
authors.forename: Teresa T
authors.initials: TT
authors.lastname: Yiu
authors.affiliation: Dan L Duncan Cancer Center, 1 Baylor Plaza 450A, Houston, TX 77030, USA.|Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D019175:DNA Methylation; D004777:Environment; D044127:Epigenesis, Genetic; D057890:Epigenomics; D005492:Folic Acid / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D059647:Gene-Environment Interaction; D006657:Histones / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*
chemical_list: D006657:Histones; D005492:Folic Acid
keywords: DNA methylation; cancer prevention; childhood cancer; epigenetics; folate; histone modifications; therapeutics