title: Stomatin-like protein 2 expression is associated with clinical survival in patients with cervical cancer.
abstract: OBJECTIVE
  To investigate the prognostic role of stomatin-like protein 2 (STOML2) in cervical cancer.
  
  
  METHODS
  The expression of STOML2 in 8 pairs of cervical cancer and adjacent normal cervical tissues were detected by Real-time PCR. Immunohistochemistry was performed to evaluation of STOML2 expression in 94 paraffin-embedded cervical cancer samples. The correlation between STOML2 expression and cervical cancer progression and prognosis was analyzed statistically.
  
  
  RESULTS
  STOML2 expression was upregulated in cervical cancer tissues compared with adjacent normal cervical tissues. Of the 94 cervical cancer cases, high STOML2 expression was detected in 54 cases (57.4%). STOML2 expression was significantly related to tumor stage (P = 0.013) and tumor size (P = 0.025). Moreover, patients with high expression of STOML2 had a significant shorter overall survival and recurrent free survival time compared with those with low STOML2 expression in cervical cancer (P = 0.001 and P = 0.017, respectively). Multivariate analysis revealed that STOML2 was an independent prognostic factor (P = 0.022) for the overall survival in cervical cancer.
  
  
  CONCLUSIONS
  Our study showed STOML2 was correlated to progression in cervical cancer, and implicated it as a potential predictive factor for the prognosis of cervical cancer.
authors.affiliation: Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
authors.forename: Binmei
authors.initials: B
authors.lastname: Xiao
authors.affiliation: Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Guo
authors.affiliation: Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
authors.forename: Jianchi
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Gynaecology and Obstetrics, The Second Xiangya Hospital Central South University Changsha, HN 410011, China.
authors.forename: Hongwen
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001798:Blood Proteins / Q000032:analysis* / Q000235:genetics; D016009:Chi-Square Distribution; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008565:Membrane Proteins / Q000032:analysis* / Q000235:genetics; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D016612:Paraffin Embedding; D016016:Proportional Hazards Models; D012333:RNA, Messenger / Q000032:analysis; D060888:Real-Time Polymerase Chain Reaction; D012307:Risk Factors; D013997:Time Factors; D047368:Tumor Burden; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000401:mortality / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; C406287:STOML2 protein, human
keywords: STOML2; cervical cancer; overall survival; recurrent free survival