title: Small molecule binding to a G-hairpin and a G-triplex: a new insight into anticancer drug design targeting G-rich regions.
abstract: To gain new insights into G-quadruplex-drug interactions, we captured the solution-state structures of the complexes between a drug-like small molecule and a G-hairpin/G-triplex. Our results indicated that the ligand initially binds to the intermediates and induces stepwise folding into a quadruplex.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan. hs@kuchem.kyoto-u.ac.jp.
authors.forename: Arivazhagan
authors.initials: A
authors.lastname: Rajendran
authors.forename: Masayuki
authors.initials: M
authors.lastname: Endo
authors.forename: Kumi
authors.initials: K
authors.lastname: Hidaka
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Teulade-Fichou
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Mergny
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D001710:Biotin / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D006147:Guanine / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011725:Pyridines; D006147:Guanine; D001710:Biotin; D004247:DNA