title: Non-dopamine receptor ligands for the treatment of Parkinson's disease. Insight into the related chemical/property space.
abstract: Extensive biochemical and clinical studies have increasingly recognized Parkinson's disease as a highly complex and multi-faceted neurological disorder having branched non-motor symptoms including sleep disorders, pain, constipation, psychosis, depression, and fatigue. A wide range of biological targets in the brain deeply implicated in this pathology resulted in a plethora of novel small-molecule compounds with promising activity. This review thoroughly describes the chemical space of non-dopamine receptor ligands in terms of diversity, isosteric/bioisosteric morphing, and molecular descriptors.
authors.affiliation: Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny, Moscow Region, 141700, Russian Federation. yai@chemdiv.com.|ChemDiv, 6605 Nancy Ridge Drive, San Diego, CA, 92121, USA. yai@chemdiv.com.|Chemistry Department, Moscow State University, Leninskie Gory, Building 1/3, Moscow, 119991, Russian Federation. yai@chemdiv.com.
authors.forename: Yan A
authors.initials: YA
authors.lastname: Ivanenkov
authors.affiliation: Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny, Moscow Region, 141700, Russian Federation.|Chemistry Department, Moscow State University, Leninskie Gory, Building 1/3, Moscow, 119991, Russian Federation.|National University of Science and Technology MISiS, 9 Leninskiy pr., Moscow, 119049, Russian Federation.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Veselov
authors.affiliation: Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny, Moscow Region, 141700, Russian Federation.|National University of Science and Technology MISiS, 9 Leninskiy pr., Moscow, 119049, Russian Federation.
authors.forename: Nina V
authors.initials: NV
authors.lastname: Chufarova
authors.affiliation: Chemistry Department, Moscow State University, Leninskie Gory, Building 1/3, Moscow, 119991, Russian Federation.|National University of Science and Technology MISiS, 9 Leninskiy pr., Moscow, 119049, Russian Federation.
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Majouga
authors.affiliation: Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny, Moscow Region, 141700, Russian Federation.
authors.forename: Anna A
authors.initials: AA
authors.lastname: Kudryavceva
authors.affiliation: ChemDiv, 6605 Nancy Ridge Drive, San Diego, CA, 92121, USA.
authors.forename: Alexandre V
authors.initials: AV
authors.lastname: Ivachtchenko
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D007536:Isomerism; D008024:Ligands; D015394:Molecular Structure; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011954:Receptors, Dopamine / Q000378:metabolism; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D008024:Ligands; D011954:Receptors, Dopamine; D054852:Small Molecule Libraries
keywords: Bioisosteres; Descriptors; Diversity; Drugs; Non-dopamine; Parkinson’s disease