title: Infective endocarditis in the Pacific: clinical characteristics, treatment and long-term outcomes.
abstract: Data on clinical characteristics and outcomes of infective endocarditis (IE) in the Pacific are scarce.
  
  
  
  Retrospective hospital-based study in New Caledonia, a high-income country, on patients aged over 18 years with definite IE according to the modified Duke criteria (2005-2010).
  
  
  
  51 patients were included: 31 (60.8%) men; median age of 52.4 years (IQR 33.0-70.0). Left-sided IE accounted for 47 (92.2%) patients: native valve IE in 34 (66.7%) and prosthetic valve IE in 13 (25.5%). The main underlying heart disease included: rheumatic valve disease in 19 (37.3%), degenerative heart valve disease in 12 (23.5%) and congenital heart disease in 6 (11.8%). Significant comorbidities (Charlson's score >3) were observed in 20 (38.7%) patients. Infection was community acquired in 43 (84.3%) patients. Leading pathogens included Staphylococcus aureus in 16 (31.4%) and Streptococcus spp in 15 (29.4%) patients. Complications were noted in 33 patients (64.7%) and 24 (47.1%) were admitted to the intensive care unit. Cardiac surgery was eventually performed in 22 of 40 (55.0%) patients with a theoretical indication. None underwent emergent cardiac surgery (ie, first 24 h); 2 (3.9%) were operated within 7 days; and 20 (39.2%) beyond 7 days. 11 (21.6%) patients died in hospital and 21 (42.9%) were dead after a median follow-up of 28.8 months (IQR 4.6-51.2). Two (3.9%) were lost to follow-up.
  
  
  
  In New Caledonia, IE afflicts relatively young patients with rheumatic heart disease, and carries high complication and mortality rates. Access to heart surgery remains relatively limited in this remote archipelago.
authors.affiliation: INSERM U970, Paris Cardiovascular Research Centre-PARCC , Paris , France ; Université Paris Descartes, Sorbonne Paris Cité , Paris , France ; Cardiology Department, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou , Paris , France.
authors.forename: Mariana
authors.initials: M
authors.lastname: Mirabel
authors.affiliation: INSERM U970, Paris Cardiovascular Research Centre-PARCC , Paris , France.
authors.forename: Romain
authors.initials: R
authors.lastname: André
authors.affiliation: INSERM U970, Paris Cardiovascular Research Centre-PARCC , Paris , France ; Cardiology Department , Hôpital Territorial de Nouvelle Calédonie , Nouméa , New Caledonia.
authors.forename: Paul
authors.initials: P
authors.lastname: Barsoum Mikhaïl
authors.affiliation: Department of Internal Medicine and Infectious Disease , Hôpital Territorial de Nouvelle Calédonie , Nouméa , New Caledonia.
authors.forename: Hester
authors.initials: H
authors.lastname: Colboc
authors.affiliation: Department of Internal Medicine and Infectious Disease , Hôpital Territorial de Nouvelle Calédonie , Nouméa , New Caledonia.
authors.forename: Flore
authors.initials: F
authors.lastname: Lacassin
authors.affiliation: Cardiology Department , Hôpital Territorial de Nouvelle Calédonie , Nouméa , New Caledonia.
authors.forename: Baptiste
authors.initials: B
authors.lastname: Noël
authors.affiliation: Cardiology Department , Hôpital Territorial de Nouvelle Calédonie , Nouméa , New Caledonia.
authors.forename: Jacques
authors.initials: J
authors.lastname: Robert
authors.affiliation: Cardiology Department , Hôpital Territorial de Nouvelle Calédonie , Nouméa , New Caledonia.
authors.forename: Marie
authors.initials: M
authors.lastname: Nadra
authors.affiliation: Cardiology Department , Hôpital Territorial de Nouvelle Calédonie , Nouméa , New Caledonia.
authors.forename: Corinne
authors.initials: C
authors.lastname: Braunstein
authors.affiliation: Department of Bioinformatics , Hôpital Territorial de Nouvelle Calédonie , Nouméa , New Caledonia.
authors.forename: Shirley
authors.initials: S
authors.lastname: Gervolino
authors.affiliation: INSERM U970, Paris Cardiovascular Research Centre-PARCC , Paris , France ; Université Paris Descartes, Sorbonne Paris Cité , Paris , France ; Cardiology Department, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou , Paris , France.
authors.forename: Eloi
authors.initials: E
authors.lastname: Marijon
authors.affiliation: Cardiology Department , Hôpital Bichat and Paris Diderot University , Paris , France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Iung
authors.affiliation: INSERM U970, Paris Cardiovascular Research Centre-PARCC , Paris , France ; Université Paris Descartes, Sorbonne Paris Cité , Paris , France ; Cardiology Department, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou , Paris , France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Jouven
keywords: VALVULAR DISEASE