title: Novel Association of Killer Cell Immunoglobulin-like Receptor Genes with EBV-infectious Diseases in Children.
abstract: Killer cell immunoglobulin-like receptors (KIRs) which are mainly expressed on natural killer (NK) cells are implicated in many virus infections. However, it is unclear whether or not KIRs are associated with susceptibility to Epstein-Barr virus (EBV) infection related diseases. Therefore, the purpose of our study was to investigate possible correlation between polymorphisms of KIR genes and infectious mononucleosis (IM)/EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH). The polymorphisms of KIR genes were detected by polymerase chain reaction with sequence-specific primers (PCR-SSP). The results would contribute to clarify the association of KIRs with EBV induced diseases, and provide new insights into the role of NK cells and innate immune response against viral infections and/or subsequent progression.
authors.affiliation: Department of Pediatric Hematology/Oncology, West China Second University Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Department of Emergency, West China Second University Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Huo
authors.affiliation: Department of Pediatric Hematology/Oncology, West China Second University Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Ming Yan
authors.initials: MY
authors.lastname: Jiang
authors.affiliation: Department of Pediatric Hematology/Oncology, West China Second University Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Pediatric Hematology/Oncology, West China Second University Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Yi Ping
authors.initials: YP
authors.lastname: Zhu
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D018450:Disease Progression; D005260:Female; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D007244:Infectious Mononucleosis / Q000235:genetics* / Q000276:immunology / Q000821:virology; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D051359:Lymphohistiocytosis, Hemophagocytic / Q000235:genetics* / Q000276:immunology / Q000821:virology; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D054340:Receptors, KIR / Q000235:genetics* / Q000378:metabolism
chemical_list: D054340:Receptors, KIR