title: [Cytogenetic characteristics of 163 children with acute lymphoblastic leukemia].
abstract: OBJECTIVE
  To further understand the cytogenetic characteristics of pediatric acute lymphoblastic leukemia (ALL).
  
  
  METHODS
  Cytogenetic abnormalities of 163 children with newly diagnosed ALL (0-17 years of age) were evaluated by conventional cytogenetic analysis and fluorescent in situ hybridization findings.
  
  
  RESULTS
  Chromosome abnormalities were detected in 87.7% of patients (143/163). The ploidy levels most frequently observed among ALL patients were high hyperdiploidy (51-67 chromosomes) (45 cases, 27.6%), Chromosomes X and 21 were gained in 100% of these cases. The most common genetic alterations were t(12;21)/ETV6/RUNX1 (26 cases, 16.0%), followed by t(1;19)/TCF3/PBX1 (13 patients, 8.0%), t(4;11)/MLL rearrangement and t(8;14) IGH/MYC (6 cases, 3.7%), t(9;22)/BCR/ABL(2 cases, 1.2%), and iAMP21 (1 patient, 0.6%). The no-classical structural abnormalities included dup(1q) in 20.2%, del(6q) and del(9p) in 10.4%, del(12p) in 12.9% and del(13q) in 5.5%. The incidences of t(12;21), t(1;19), t(9;22) and high hyperdiploidy were consistent with reports in Western children (P>0.25). The incidence of (9;22) seemed to be much lower in our study than that in Korea (1.5% vs 9.5%, P<0.005).
  
  
  CONCLUSIONS
  Cytogenetic findings of childhood ALL patients are similar to that of Western countries, it seems no more adverse risk factors.
authors.affiliation: Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai 201102, China. E-mail: xhguo@shmu.edu.cn.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Guo
authors.affiliation: Department of Hematology, Children's Hospital of Fudan University, Shanghai 201102, China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Zhai
authors.affiliation: Department of Hematology, Children's Hospital of Fudan University, Shanghai 201102, China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Qian
authors.affiliation: Department of Hematology, Children's Hospital of Fudan University, Shanghai 201102, China.
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Wang
authors.affiliation: Department of Hematology, Children's Hospital of Fudan University, Shanghai 201102, China.
authors.forename: Cui-Qing
authors.initials: CQ
authors.lastname: Fan
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D020732:Cytogenetic Analysis; D016044:Fusion Proteins, bcr-abl; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma
chemical_list: D016044:Fusion Proteins, bcr-abl