title: High-Risk Populations: The Pimas of Arizona and Mexico.
abstract: The purpose of this review is first, to broadly summarize the long-term commitment that began in 1965 to studying type 2 diabetes and obesity through the cooperation of the Pima Indians of Arizona, and second, to discuss the investigations with the Pima Indians of Mexico that started in 1991. The later studies emphasize gene-environment interactions in the pathogenesis of these metabolic disorders. Through the participation of both groups of Pimas, the researchers made key findings with regard to the epidemiology, physiology, clinical assessment and genetics of type 2 diabetes and obesity.
authors.affiliation: College of Health and Human Services, Northern Arizona University, PO Box 15015, Flagstaff, AZ 86011, USA.
authors.forename: Leslie O
authors.initials: LO
authors.lastname: Schulz
authors.affiliation: Department of Health Sciences, Northern Arizona University, PO Box 15095, Flagstaff, AZ 86011, USA.
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Chaudhari
mesh_terms: D001130:Arizona; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000235:genetics; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D007198:Indians, North American / Q000235:genetics; D008800:Mexico; D009765:Obesity / Q000209:etiology* / Q000235:genetics
keywords: Arizona; Mexico; Pima Indians; Type 2 diabetes; environment; genetics; lifestyle; obesity