title: 25-gauge pars plana vitrectomy with medium-term postoperative perfluoro-n-octane for the repair of giant retinal tears.
abstract: OBJECTIVE
  The purpose of this study was to describe the treatment of giant retinal tears (GRTs) with 25-gauge pars plana vitrectomy (PPV) and medium-term postoperative perfluoro-n-octane (MT-PFO).
  
  
  METHODS
  The study was a retrospective interventional case series of consecutive patients with GRTs treated with 25-gauge PPV and postoperative MT-PFO for a period of 2-3 weeks. A second, staged procedure was performed in all patients for PFO removal.
  
  
  RESULTS
  Twenty-three eyes of 22 patients were studied, with a mean follow-up of 33.04 ± 19.74 months. Successful reattachment was achieved in 91.3 % of eyes (21/23) after MT-PFO. Retinal re-detachment occurred in five eyes, which was caused by proliferative vitreoretinopathy. Additional complications included cataract progression (n = 10), foreign body response (30.4 %, 7/23), and transient intraocular pressure (IOP) elevation (8/23, 34.8 %). Transient IOP elevation was associated with worse visual outcome (p = 0.01).
  
  
  CONCLUSIONS
  MT-PFO was found to be an effective and safe technique for operative management of GRTs. In the majority of patients, retinas remained attached without further surgical intervention. Cataract progression, intraocular inflammation, and associated increased intraocular pressure are potential complications of MT-PFO.
authors.affiliation: Department of Vitreoretinal Surgery, Charles Retina Institute, 6401 Poplar Avenue, Suite 190, Memphis, TN, 38119, USA.|Department of Vitreoretinal Surgery, Center for Retina and Macular Disease, Winter Haven, FL, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Randolph
authors.affiliation: Department of Vitreoretinal Surgery, Charles Retina Institute, 6401 Poplar Avenue, Suite 190, Memphis, TN, 38119, USA. rociodiaz12@gmail.com.
authors.forename: Rocio I
authors.initials: RI
authors.lastname: Diaz
authors.affiliation: Department of Vitreoretinal Surgery, Charles Retina Institute, 6401 Poplar Avenue, Suite 190, Memphis, TN, 38119, USA.|Division of Medical and Surgical Diseases of the Retina, Vitreous and Macula, Ophthalmic Consultants of Long Island, Lynbrook, NY, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Sigler
authors.affiliation: Department of Vitreoretinal Surgery, Charles Retina Institute, 6401 Poplar Avenue, Suite 190, Memphis, TN, 38119, USA.
authors.forename: Jorge I
authors.initials: JI
authors.lastname: Calzada
authors.affiliation: Department of Vitreoretinal Surgery, Charles Retina Institute, 6401 Poplar Avenue, Suite 190, Memphis, TN, 38119, USA.
authors.forename: Steve
authors.initials: S
authors.lastname: Charles
mesh_terms: D000328:Adult; D058450:Endotamponade; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011184:Postoperative Period; D012167:Retinal Perforations / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy / Q000379:methods*
chemical_list: D005466:Fluorocarbons; C073608:perfluorooctane
keywords: Giant retinal tear; Medium-term PFO; Pars plana vitrectomy; Perfluoro-n-octane; Perfluorocarbon heavy liquid; Retinal detachment