title: IGFBP-3 A-202C and C2133G polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies.
abstract: Recent evidence suggests that genetic variations in the IGFBP-3 gene may impact susceptibility to colorectal cancer, but individually published results are inconclusive. Our meta-analysis was aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 1, 2013. This meta-analysis was performed using the STATA 12.0 software. The crude odds ratios (OR) with 95% confidence interval (CI) were calculated. Eleven case-control studies were included with a total of 11,895 colorectal cancer patients and 17,147 healthy controls. Our meta-analysis indicated that the G variant of IGFBP-3 C2133G polymorphism may be associated with increased colorectal cancer risk. However, no statistically significant association was noted between IGFBP-3 A-202C polymorphism and colorectal cancer risk. No publication bias was detected in this meta-analysis. The current meta-analysis suggests that the IGFBP-3 C2133G polymorphism may confer susceptibility to colorectal cancer. The G variant of the IGFBP-3 C2133G polymorphism may serve as a useful biomarker for predicting the risk of colorectal cancer.
authors.affiliation: Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China czyy_xj@126.com.
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Vascular Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: L T
authors.initials: LT
authors.lastname: Li
authors.affiliation: Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Q
authors.initials: Q
authors.lastname: You
authors.affiliation: Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
authors.forename: L S
authors.initials: LS
authors.lastname: Cha
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3