title: Association between toll-like receptors 9 (TLR9) gene polymorphism and risk of pulmonary tuberculosis: meta-analysis.
abstract: BACKGROUND
  Previous studies indicated that the single nucleotide polymorphisms (SNPs) in TLR9 gene might be associated with Tuberculosis (TB) risk. However, the results are inconsistent and inconclusive.
  
  
  METHODS
  1745 articles from four databases were involved in our study. A meta-analysis on the associations between the seven polymorphisms and TB risk was carried out by comparison using different genetic models.
  
  
  RESULTS
  In this systematic review 8 studies from seven English articles were analyzed. Our results showed that rs352139 is significantly associated with TB risk (AA vs. AG, OR 0.77, 95% CI 0.65-0.92, P = 0.004). In the ethnic subgroup analysis, Indonesians with AA genotype had a decreased susceptibility while Mexicans with GG allele had an increased risk.
  
  
  CONCLUSIONS
  The meta-analysis indicated that rs352139 polymorphism might be associated with decreased TB risk in Indonesians whereas increased risk in Mexicans. Whether the observed association was due to causal effect needs to be further studied.
authors.affiliation: Department of Tuberculosis, The 309th hospital of PLA, No. 17, Heishanhu Road, Haidian District, Beijing, 100091, China. chenzhidoctor@126.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Tuberculosis, The 309th hospital of PLA, No. 17, Heishanhu Road, Haidian District, Beijing, 100091, China. wangweidoctor123@sina.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Tuberculosis, The 309th hospital of PLA, No. 17, Heishanhu Road, Haidian District, Beijing, 100091, China. liangjqdoctor123@sina.com.
authors.forename: Jianqin
authors.initials: J
authors.lastname: Liang
authors.affiliation: Department of Tuberculosis, The 309th hospital of PLA, No. 17, Heishanhu Road, Haidian District, Beijing, 100091, China. wangjhdoctor123@sina.com.
authors.forename: Jinhe
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Tuberculosis, The 309th hospital of PLA, No. 17, Heishanhu Road, Haidian District, Beijing, 100091, China. fengssdoctor123@sina.com.
authors.forename: Shisheng
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Tuberculosis, The 309th hospital of PLA, No. 17, Heishanhu Road, Haidian District, Beijing, 100091, China. chenzhidoctor@sina.com.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000354:Africa, Western; D000483:Alleles; D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D003105:Colombia; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D007198:Indians, North American / Q000235:genetics; D007214:Indonesia; D007492:Iran; D008800:Mexico; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D051217:Toll-Like Receptor 9 / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*; D014744:Vietnam; D044465:White People / Q000235:genetics
chemical_list: C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9