title: Kinetics of B-type natriuretic peptide plasma levels in patients with left-sided breast cancer treated with radiation therapy: Results after one-year follow-up.
abstract: OBJECTIVE
  To analyze temporal changes of B-type natriuretic peptide (BNP) used as index of heart remodeling in left-sided breast cancer patients after radiotherapy (RT) and its relationship with dosimetric parameters.
  
  
  METHODS
  BNP and dose-volume parameters for heart and ventricle were collected in 59 patients (median age 58.0 years) during a 1-year follow-up. Biochemical measurements were performed before the RT treatment (T0), at 15 days during RT (T(15day)), at the end of RT (T(endRT)), and then at 1, 3, 6, 9, 12 months (T1, T3, T6, T9 and T12). A logistical regression analysis was performed to identify demographic characteristics, dosimetric variables and risk factors associated with increased values of BNP.
  
  
  RESULTS
  The ratio between the BNP value at T12 and the BNP value at T0 (BNP(T12)/BNP(T0)) increased significantly (p < 0.01). A significant association was found between the variation of BNP values after 1 year and the isodose received by 50% of the volume (D50% [Gy]) both to the heart (p = 0.03) and ventricle (p = 0.04).
  
  
  CONCLUSIONS
  BNP plasma levels could provide additional information about subclinical RT-induced cardiotoxicity earlier than traditional ecocardiographic data.
authors.affiliation: a Department of Laboratory Medicine , Brindisi , Italy.
authors.forename: Maria Patrizia
authors.initials: MP
authors.lastname: D'Errico
authors.affiliation: b Department of Radiotherapy , "A. Perrino" Hospital , Brindisi , Italy.
authors.forename: Maria Fonte
authors.initials: MF
authors.lastname: Petruzzelli
authors.affiliation: c Institute of Clinical Physiology - National Research Council (IFC-CNR) , Pisa-Lecce , Italy.|f Johannes Gutenberg-Universität Mainz, Institut für Medizinische Biometrie, Epidemiologie und Informatik , Mainz , Germany.
authors.forename: Emilio A L
authors.initials: EA
authors.lastname: Gianicolo
authors.affiliation: d Department of Medical Physics "A. Perrino" Hospital , Brindisi , Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Grimaldi
authors.affiliation: e Department of Cardiology "Umberto I" Hospital , Fasano (Brindisi) , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Loliva
authors.affiliation: b Department of Radiotherapy , "A. Perrino" Hospital , Brindisi , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Tramacere
authors.affiliation: c Institute of Clinical Physiology - National Research Council (IFC-CNR) , Pisa-Lecce , Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Andreassi
authors.affiliation: d Department of Medical Physics "A. Perrino" Hospital , Brindisi , Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Pili
authors.affiliation: c Institute of Clinical Physiology - National Research Council (IFC-CNR) , Pisa-Lecce , Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Picano
authors.affiliation: b Department of Radiotherapy , "A. Perrino" Hospital , Brindisi , Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Portaluri
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000528:radiation effects; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011832:Radiation Injuries / Q000097:blood*; D011874:Radiometry; D000069584:Unilateral Breast Neoplasms / Q000097:blood* / Q000378:metabolism / Q000532:radiotherapy*
chemical_list: D020097:Natriuretic Peptide, Brain
keywords: Radiotherapy; brain natriuretic peptide; breast cancer; cardiotoxicity; dosimetric parameters