title: Highly enantioselective and anti-diastereoselective catalytic intermolecular glyoxylate-ene reactions: effect of the geometrical isomers of alkenes.
abstract: An efficient method for the synthesis of homoallylic alcohols with high enantioselectivities and anti-diastereoselectivities via an In(III)-catalyzed intermolecular glyoxylate-ene reaction has been developed. The geometrical isomers of alkenes were shown to have different reactivities. Only the isomers of the alkenes having a proton β-cis to the substituent reacted in this catalytic system.
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Ding
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
authors.forename: Yun-He
authors.initials: YH
authors.lastname: Xu
authors.affiliation: †Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.|‡Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006038:Glyoxylates / Q000737:chemistry*; D007204:Indium / Q000737:chemistry*; D007536:Isomerism; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000475:Alkenes; D006038:Glyoxylates; D007204:Indium; C031150:glyoxylic acid