title: Radiotherapy combined with chemotherapy versus radiotherapy alone for early stage nasal natural killer/T-cell lymphoma: a meta-analysis.
abstract: OBJECTIVE
  To compare the efficacy of radiotherapy (RT) plus chemotherapy (CMT) versus RT alone for early stage nasal natural killer (NK)/T-cell lymphoma.
  
  
  METHODS
  All the eligible studies were searched by PubMed, Medline, Embase and the Cochrane Library. The meta-analysis was performed to compare odds ratios (ORs) for overall survival (OS), disease-free survival (DFS) and progression-free survival (PFS).
  
  
  RESULTS
  Eight studies were included in the meta-analysis. Chemotherapy group did not significantly differ from RT group. The pooled OR and 95% confidence interval (CI) for 1-year, 3-year, 5-year and 10-year OS was 1.25 [0.84, 1.87], 1.10 [0.76, 1.58], 0.83 [0.59, 1.17] and 1.05 [0.70, 1.56]. In addition, the combined OR and 95% CI for 5-year DFS and PFS were 0.96 [0.53, 1.73] and 0.71 [0.45, 1.12].
  
  
  CONCLUSIONS
  The current evidence suggests that CMT was not superior to RT alone. Radiotherapy may be still the main method in the treatment of early stage nasal NK/T-cell lymphoma.
authors.affiliation: a Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy , West China Hospital, Sichuan University , Chengdu , China.
authors.forename: Binglan
authors.initials: B
authors.lastname: Zhang
authors.affiliation: b Department of Hepatobiliary Surgery , The Ninth People's Hospital of Chongqing , Chongqing , China.
authors.forename: Fuping
authors.initials: F
authors.lastname: Zhu
authors.affiliation: a Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy , West China Hospital, Sichuan University , Chengdu , China.
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: a Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy , West China Hospital, Sichuan University , Chengdu , China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Zhao
authors.affiliation: a Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy , West China Hospital, Sichuan University , Chengdu , China.
authors.forename: Minmin
authors.initials: M
authors.lastname: Li
authors.affiliation: a Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy , West China Hospital, Sichuan University , Chengdu , China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.affiliation: a Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy , West China Hospital, Sichuan University , Chengdu , China.
authors.forename: Juan
authors.initials: J
authors.lastname: Huang
authors.affiliation: a Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy , West China Hospital, Sichuan University , Chengdu , China.
authors.forename: Liqun
authors.initials: L
authors.lastname: Zou
authors.affiliation: b Department of Hepatobiliary Surgery , The Ninth People's Hospital of Chongqing , Chongqing , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chang
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D059248:Chemoradiotherapy; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000473:pathology / Q000628:therapy*; D009296:Nasal Cavity / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects*; D009367:Neoplasm Staging; D009669:Nose Neoplasms / Q000473:pathology / Q000628:therapy*; D011878:Radiotherapy; D016896:Treatment Outcome
keywords: Chemotherapy; Meta-analysis; NK/T-cell lymphoma; Radiotherapy