title: Effect of Mg(2+), Ca(2+), Sr(2+) and Ba(2+) metal ions on the antifungal activity of ZnO nanoparticles tested against Candida albicans.
abstract: The antifungal ability of pure and alkaline metal ion (Mg(2+), Ca(2+), Sr(2+) and Ba(2+)) doped ZnO nanoparticles (NPs) prepared by the co-precipitation method was tested against the pathogenic yeast, Candida albicans (C. albicans), and the results showed that the Mg-doped ZnO NPs possessed greater effect than the other alkaline metal ion doped ZnO NPs. The impact of the concentration of Mg doped ZnO sample on the growth of C. albicans was also studied. The Minimal Fungicidal Concentration (MFC) of the Mg doped ZnO NPs was found to be 2000 μg/ml for which the growth of C. albicans was completely inhibited. The ZnO:Mg sample (1.5mg/ml) with various concentrations of histidine reduced the fungicidal effect of the nanoparticles against C. albicans, which was deliberately explained by the role of ROS. The ZnO:Mg sample added with 5mM of histidine scavenged the ample amount of generated ROS effectively. The binding of the NPs with fungi was observed by their FESEM images and their electrostatic attraction is confirmed by the zeta potential measurement.
authors.affiliation: PG and Research Department of Physics, Jamal Mohamed College, Tiruchirappalli 620 020, Tamil Nadu, India. Electronic address: hajahameed2001@gmail.com.
authors.forename: Abdulrahman Syedahamed
authors.initials: AS
authors.lastname: Haja Hameed
authors.affiliation: PG and Research Department of Physics, Jamal Mohamed College, Tiruchirappalli 620 020, Tamil Nadu, India.
authors.forename: Chandrasekaran
authors.initials: C
authors.lastname: Karthikeyan
authors.affiliation: Department of Plant Biology and Plant Biotechnology, R.K.M. Vivekananda College, Chennai 600 004, Tamil Nadu, India.
authors.forename: Venugopal
authors.initials: V
authors.lastname: Senthil Kumar
authors.affiliation: Department of Plant Biology and Plant Biotechnology, R.K.M. Vivekananda College, Chennai 600 004, Tamil Nadu, India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Kumaresan
authors.affiliation: PG and Research Department of Physics, Jamal Mohamed College, Tiruchirappalli 620 020, Tamil Nadu, India.
authors.forename: Seemaisamy
authors.initials: S
authors.lastname: Sasikumar
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001464:Barium / Q000737:chemistry / Q000494:pharmacology; D002118:Calcium / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D008274:Magnesium / Q000737:chemistry / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry*; D013324:Strontium / Q000737:chemistry / Q000494:pharmacology; D015034:Zinc Oxide / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D001464:Barium; D008274:Magnesium; D015034:Zinc Oxide; D002118:Calcium; D013324:Strontium
keywords: Antifungal activity; Candida albicans; Metal doping; SEM; XRD; ZnO nanoparticles