title: [Impact of radiotherapy on female fertility].
abstract: Radiation therapy may have deleterious effects on female fertility. It can cause ovarian dysfunction, uterine damages or disrupt the hypothalamic-pituitary axis. These effects occur at varying dose levels usually relatively low compared to the prescribed doses. Other co-factors influence the effects of radiation therapy on fertility, such as age or therapy with alkylating agents. This review aims to make an update on the current state of knowledge about the impact of radiotherapy on female fertility.
authors.affiliation: Gustave-Roussy Cancer Campus, département de radiothérapie, service de curiethérapie, Villejuif, France. Electronic address: renaud.mazeron@gustaveroussy.fr.
authors.forename: Renaud
authors.initials: R
authors.lastname: Mazeron
authors.affiliation: Gustave-Roussy Cancer Campus, département de radiothérapie, service de curiethérapie, Villejuif, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Maroun
authors.affiliation: Gustave-Roussy Cancer Campus, département de radiothérapie, service de curiethérapie, Villejuif, France.
authors.forename: Kim
authors.initials: K
authors.lastname: Cao
authors.affiliation: Gustave-Roussy Cancer Campus, département de radiothérapie, service de curiethérapie, Villejuif, France.
authors.forename: Rodrigue
authors.initials: R
authors.lastname: Mbagui
authors.affiliation: Gustave-Roussy Cancer Campus, département de radiothérapie, service de curiethérapie, Villejuif, France.
authors.forename: Andrea
authors.initials: A
authors.lastname: Slocker-Escarpa
authors.affiliation: Gustave-Roussy Cancer Campus, département de radiothérapie, service de curiethérapie, Villejuif, France.
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chargari
authors.affiliation: Gustave-Roussy Cancer Campus, département de radiothérapie, service de curiethérapie, Villejuif, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Haie-Meder
mesh_terms: D000367:Age Factors; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000528:radiation effects; D008954:Models, Biological; D010053:Ovary / Q000528:radiation effects* / Q000601:surgery; D011247:Pregnancy; D011879:Radiotherapy Dosage; D014599:Uterus / Q000528:radiation effects*
chemical_list: D018906:Antineoplastic Agents, Alkylating
keywords: Cancer; Dose; Female fertility; Fertilité féminine; Ovaire; Ovary; Radiotherapy; Radiothérapie