title: Rifins, rosetting, and red blood cells.
abstract: The binding of multiple uninfected erythrocytes to a central malaria parasite-infected erythrocyte (IE) is called rosetting. Rosetting has been associated with severe disease, but its functional significance,and the host receptors and parasite ligands involved are only partially known. A recent study, which describes yet another piece in this already complex puzzle, provides a welcome boost and a broadening of an important malaria research field.
authors.affiliation: Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
authors.forename: Christian W
authors.initials: CW
authors.lastname: Wang
authors.affiliation: Centre for Medical Parasitology at Department of Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark. Electronic address: lhviid@sund.ku.dk.
authors.forename: Lars
authors.initials: L
authors.lastname: Hviid
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000502:physiology*; D004912:Erythrocytes / Q000469:parasitology*; D006801:Humans; D016778:Malaria, Falciparum / Q000378:metabolism*; D008297:Male; D010963:Plasmodium falciparum / Q000378:metabolism*; D015800:Protozoan Proteins / Q000502:physiology*
chemical_list: D000953:Antigens, Protozoan; D015800:Protozoan Proteins
keywords: ABO blood type; PfEMP1; RIFINs; malaria; rosetting; sequestration