title: The effect of autologous bone marrow mononuclear cell transplantation on the survival duration in Amyotrophic Lateral Sclerosis - a retrospective controlled study.
abstract: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disorder with fatal prognosis. Cellular therapy has been studied for ALS in various animal models and these advances have highlighted its potential to be a treatment modality. This is a retrospective controlled cohort study of total 57 patients. Out of these, 37 patients underwent autologous bone marrow mononuclear cell transplantation in addition to standard rehabilitation and Riluzole. Control group consisted of 20 patients who did not receive cell transplantation. The survival duration since the onset of the disease for both the groups was computed using a Kaplan-Meier Survival analysis and compared using log-rank test. Effect of age at onset, type of onset and lithium on survival duration in the intervention group was analyzed. Mean survival duration of patients in intervention group was 87.76 months which was higher than the control group mean survival duration of 57.38 months. Survival duration was significantly (p = 0.039) higher in people with the onset of the disease below 50 years of age. Limb onset and lithium also showed positive influence on the survival duration. Mean survival duration of the intervention group was also higher than the survival duration of ALS patients in previous epidemiological studies. In addition to the standard treatment with Riluzole, early intervention with combination of BMMNCs transplantation and Lithium may have a positive effect on the survival duration in ALS. Prospective randomized controlled studies with a larger sample size and rigorous methodology are required for conclusive findings.
authors.affiliation: NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Center Plot No. 19, Next to Seawood Grand Central Station (West), off Palm Beach Road, Navi Mumbai 400706, Maharashtra, India.
authors.forename: Alok K
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: Department of Research and Development, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Center Plot No. 19, Next to Seawood Grand Central Station (West), off Palm Beach Road, Navi Mumbai 400706, Maharashtra, India.
authors.forename: Hemangi M
authors.initials: HM
authors.lastname: Sane
authors.affiliation: NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Center Plot No. 19, Next to Seawood Grand Central Station (West), off Palm Beach Road, Navi Mumbai 400706, Maharashtra, India.
authors.forename: Amruta A
authors.initials: AA
authors.lastname: Paranjape
authors.affiliation: Department of Medical Services and Clinical Research, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Center Plot No. 19, Next to Seawood Grand Central Station (West), off Palm Beach Road, Navi Mumbai 400706, Maharashtra, India.
authors.forename: Nandini
authors.initials: N
authors.lastname: Gokulchandran
authors.affiliation: NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Center Plot No. 19, Next to Seawood Grand Central Station (West), off Palm Beach Road, Navi Mumbai 400706, Maharashtra, India.
authors.forename: Anjana
authors.initials: A
authors.lastname: Nagrajan
authors.affiliation: NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Center Plot No. 19, Next to Seawood Grand Central Station (West), off Palm Beach Road, Navi Mumbai 400706, Maharashtra, India.
authors.forename: Myola
authors.initials: M
authors.lastname: D'sa
authors.affiliation: NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Center Plot No. 19, Next to Seawood Grand Central Station (West), off Palm Beach Road, Navi Mumbai 400706, Maharashtra, India.
authors.forename: Prerna B
authors.initials: PB
authors.lastname: Badhe
keywords: Amyotrophic Lateral Sclerosis; Motor Neuron Disease; autologous bone marrow mononuclear cells; cellular therapy; stem cell therapy; stem cells