title: Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide.
abstract: A fast-setting calcium-silicate cement (Endocem) was introduced in the field of dentistry for use in vital pulp therapy. Similar to mineral trioxide aggregate (MTA), it contains bismuth oxide to provide radiopacity. Recently, another product, EndocemZr, which contains zirconium oxide (ZrO2) as a radiopacifier, was developed by the same company. In this study, the biological/odontogenic effects of EndocemZr were investigated in human primary dental pulp cells (hpDPCs) in vitro and on capped rat teeth in vivo. The biocompatibility of EndocemZr was similar to that of ProRoot and Endocem on the basis of cell viability tests and cell morphological analysis. The mineralization nodule formation, expression of odontogenic-related markers, and reparative dentin formation of EndocemZr group was similar to those of other material groups. Our results suggest that EndocemZr has the potential to be used as an effective material for vital pulp therapy, similar to ProRoot and Endocem.
authors.affiliation: Department of Conservative Dentistry, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University.
authors.forename: Kyoung-A
authors.initials: KA
authors.lastname: Kim
authors.forename: Yeon-Mi
authors.initials: YM
authors.lastname: Yang
authors.forename: Young-Sun
authors.initials: YS
authors.lastname: Kwon
authors.forename: Yun-Chan
authors.initials: YC
authors.lastname: Hwang
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Yu
authors.forename: Kyung-San
authors.initials: KS
authors.lastname: Min
mesh_terms: D000818:Animals; D015415:Biomarkers; D017610:Calcium Compounds / Q000737:chemistry / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003738:Dental Cements; D003782:Dental Pulp / Q000166:cytology*; D005786:Gene Expression Regulation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D008963:Molar; D009805:Odontogenesis / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D017640:Silicates / Q000737:chemistry / Q000633:toxicity*; D015040:Zirconium / Q000737:chemistry / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D017610:Calcium Compounds; D003738:Dental Cements; D017640:Silicates; D015040:Zirconium; C028541:zirconium oxide; C031293:calcium silicate