title: T174M polymorphism in the angiotensinogen gene and risk of myocardial infarction: a meta-analysis.
abstract: Numerous studies have evaluated the association between the T174M polymorphism in the angiotensinogen (AGT) gene and myocardial infarction (MI) risk. However, the specific association remains controversial because of small sample sizes and varied study designs among different studies. We performed a meta-analysis to assess this correlation. A comprehensive search was conducted to identify all published articles regarding the association between the AGT gene T174M polymorphism and MI risk from different databases. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated, and heterogeneity and publication bias were assessed. A total of 1032 patients with lung cancer and 1286 controls from 6 comparative studies were included in this meta-analysis. The results revealed a significant association between the AGT gene T174M polymorphism and MI risk (MM vs TT: OR = 2.87, 95%CI = 1.71-4.83; dominant model: OR = 1.57, 95%CI = 1.10-2.25; recessive model: OR = 0.41, 95%CI = 0.25-0.66). In subgroup analysis by nationality, we observed a significant association between the AGT gene T174M polymorphism and susceptibility to MI in both Caucasian and Asian populations. In conclusion, the T174M polymorphism in the AGT gene may be related to an increased risk of MI. Further larger studies are needed to confirm these conclusions.
authors.affiliation: Department of Traumatology, Tiantai People's Hospital, Tiantai, China hu_peiyang@126.com.
authors.forename: P Y
authors.initials: PY
authors.lastname: Hu
authors.affiliation: Clinical Laboratory, Tiantai People's Hospital, Tiantai, China.
authors.forename: Y W
authors.initials: YW
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Tiantai People's Hospital, Tiantai, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Pang
authors.affiliation: General Practice, Tiantai People's Hospital, Tiantai, China.
authors.forename: H W
authors.initials: HW
authors.lastname: Wang
mesh_terms: D000595:Amino Acid Sequence; D000808:Angiotensinogen / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics; D011110:Polymorphism, Genetic; D012306:Risk
chemical_list: D000808:Angiotensinogen