title: What do epileptologists recommend about discontinuing antiepileptic drugs for a second time in children?
abstract: OBJECTIVE
  There is a broad consensus that antiepileptic drugs (AEDs) may be withdrawn after two years of seizure freedom for most children with epilepsy. If seizures recur and are, again, completely controlled with AEDs, little is known about discontinuing a second time. We surveyed American and Canadian pediatric epileptologists to understand their current practice.
  
  
  METHODS
  In 2014, a survey was sent via e-mail to 193 pediatric epileptologists to learn about AED discontinuation practices in children. The survey asked direct questions about practice and posed five "real-life" cases where the decision to discontinue might be difficult. Participants were identified through membership lists of several US and Canadian epilepsy organizations.
  
  
  RESULTS
  There were 94 (49%) completed surveys. Sixty-three participants had ≥ 10 years in practice ("more experienced": mean 23 ± 9 years), and 31 had < 10 years ("less experienced": mean 6 ± 2 ). Overall, 62% recommended AED discontinuation for the first time after 2-3 years of seizure freedom, and 61% recommended discontinuation for the second time after 2-3 years. Fifty-six percent of "more experienced" clinicians required a longer seizure-free period prior to a second discontinuation (p < 0.001) compared with 26% of "less experienced" clinicians (p = ns). Overall, most participants suggested an AED taper duration of 2-6 months for the first and second attempts, 52% and 68%, respectively. Both groups wean AEDs more slowly during the second attempt (p < 0.001). There was only 40-60% agreement among participants to discontinue AEDs in four of the cases.
  
  
  CONCLUSIONS
  Nearly half (46%) of pediatric epileptologists require a longer seizure-free period the second time they attempt to discontinue AEDs compared with the first attempt and wean down AEDs somewhat more slowly. Although a variety of factors influence decision-making, there was a high level of disagreement to discontinue AEDs a second time in "real-life" cases.
authors.affiliation: Temple University School of Medicine, Philadelphia, PA, USA.
authors.forename: Ann L
authors.initials: AL
authors.lastname: McCarthy
authors.affiliation: Department of Pediatrics, Dalhousie University and the IWK Health Centre, Halifax, Canada.
authors.forename: Carol S
authors.initials: CS
authors.lastname: Camfield
authors.affiliation: Department of Pediatrics, Dalhousie University and the IWK Health Centre, Halifax, Canada.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Camfield
authors.affiliation: Section of Neurology, St. Christopher's Hospital for Children, Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address: Ignacio.Valencia@drexelmed.edu.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Valencia
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use*; D002648:Child; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D008297:Male; D012008:Recurrence; D057832:Watchful Waiting
chemical_list: D000927:Anticonvulsants
keywords: AEDs; Discontinuation; Epilepsy; Pediatric; Survey; Treatment