title: The relationship between clinical feature, complex immunophenotype, chromosome karyotype, and outcome of patients with acute myeloid leukemia in China.
abstract: Mixed phenotype acute leukemia (MPAL) is a complex entity expressing both lymphoid and myeloid immunophenotyping. In the present study, 47 MPAL, 60 lymphoid antigen-positive acute myeloid leukemia (Ly(+)AML), and 90 acute myeloid leukemia with common myeloid immunophenotype (Ly(-)AML) patients were investigated. We found that, in MPAL patients, there were high proportions of blast cells in bone marrow and incidence of hepatosplenomegaly, lymphadenopathy, and Philadelphia chromosome. The overall survival (OS) and relapse-free survival (RFS) in MPAL patients were significantly shorter than those in Ly(+)AML and Ly(-)AML. With regard to the patients with normal karyotype only, the OS and RFS of MPAL were significantly lower than those of the Ly(+)AML and Ly(-)AML; but there were no significant differences in OS and RFS among the patients with complex karyotype. The OS rates of 3 groups with complex karyotype were lower than those of patients with normal karyotype. In Cox multivariate analysis, complex karyotype was an independent pejorative factor for both OS and RFS. Therefore, MPAL is confirmed to be a poor-risk disease while Ly(+)AML does not impact prognosis. Complex karyotype is an unfavorable prognosis factor in AML patients with different immunophenotype. Mixed immunophenotype and complex karyotype increase the adverse risk when they coexist.
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Bingjie
authors.initials: B
authors.lastname: Ding
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Xuejie
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Li
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China ; Hematology Department, Kanghua Hospital, Dongguan 523080, China.
authors.forename: Qingxiu
authors.initials: Q
authors.lastname: Zhong
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Zhengshan
authors.initials: Z
authors.lastname: Yi
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Zhongxin
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Changxin
authors.initials: C
authors.lastname: Yin
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Cao
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Libin
authors.initials: L
authors.lastname: Liao
authors.affiliation: Hematology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China ; Hematology Department, Kanghua Hospital, Dongguan 523080, China.
authors.forename: Fanyi
authors.initials: F
authors.lastname: Meng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000276:immunology*; D000950:Antigens, Ly / Q000276:immunology*; D001854:Bone Marrow Cells / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D059785:Karyotype; D015456:Leukemia, Biphenotypic, Acute / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016019:Survival Analysis
chemical_list: D015703:Antigens, CD; D000950:Antigens, Ly