title: An unusual cause of acute renal failure in sickle cell disease.
abstract: A young female with sickle cell disease was treated for biopsy-proven IgA nephropathy. Serum creatinine levels resolved to normal range, but a year later, she presented with oedema, hypertension and acute renal failure. A repeat renal biopsy showed acute-on-chronic thrombotic microangiopathy (TMA). We suggest that circulating microparticles could be a pathophysiological link between sickle cell disease and the development of renal TMA. This case emphasizes the importance of a further biopsy for acutely declining renal function, even when a definite diagnosis has been made from a previous biopsy.
authors.affiliation: Department of Nephrology.
authors.forename: Marie-Antoinette
authors.initials: MA
authors.lastname: Rockx
authors.affiliation: Department of Pathology , University of Manitoba , Winnipeg, Manitoba , Canada.
authors.forename: Ian W
authors.initials: IW
authors.lastname: Gibson
authors.affiliation: Department of Nephrology.
authors.forename: Martina
authors.initials: M
authors.lastname: Reslerova
keywords: acute renal failure; renal pathology; sickle cell disease; thrombotic microangiopathy