title: Deterministic effect of lens at leukergy of patients who received low doses of ionising radiation.
abstract: To explore the possibility to use the lens extract as an in vitro stimulator to conduct a test of stimulated leukergy in liquidators of the accident consequences (LAC) on Chernobyl Nuclear Power Plant (CNPP) with a cataract in the long-term period. The study sample included 72 men-LAC on CNPP, at the age from 42 to 65 y, who have a cataract. The comparison group consisted of 60 men, with a cataract, of the same age, and who were not exposed to radiation. The control group was composed of 60 men, at the age of 42-58 y without lens pathology. Phenomenon of the stimulated leukergy was revealed in persons who had been exposed to radiation in the dose of 18.2 ± 0.58 cGy and was observed in 5.7-8.05 % (P < 0.001), suggesting a continued high auto-aggression to the lens antigens, and the strength of cell-mediated immunity.
authors.affiliation: JSC 'Medical University Astana', Institute of Radiobiological Research, 49A Beibetshilik Str., Astana City 010000, Kazakhstan eltokova.manshuk.00@mail.ru.
authors.forename: M
authors.initials: M
authors.lastname: Yeltokova
authors.affiliation: JSC 'Medical University Astana', Institute of Radiobiological Research, 49A Beibetshilik Str., Astana City 010000, Kazakhstan.
authors.forename: D
authors.initials: D
authors.lastname: Zharliganova
authors.affiliation: JSC 'Medical University Astana', Institute of Radiobiological Research, 49A Beibetshilik Str., Astana City 010000, Kazakhstan.
authors.forename: M
authors.initials: M
authors.lastname: Shaidarov
authors.affiliation: JSC 'Medical University Astana', Institute of Radiobiological Research, 49A Beibetshilik Str., Astana City 010000, Kazakhstan.
authors.forename: M
authors.initials: M
authors.lastname: Bakhtin
authors.affiliation: JSC 'Medical University Astana', Institute of Radiobiological Research, 49A Beibetshilik Str., Astana City 010000, Kazakhstan.
authors.forename: P
authors.initials: P
authors.lastname: Kazymbet
authors.affiliation: JSC 'Medical University Astana', Institute of Radiobiological Research, 49A Beibetshilik Str., Astana City 010000, Kazakhstan.
authors.forename: L
authors.initials: L
authors.lastname: Tel
authors.affiliation: ISC 'National Medical Research Center', 42 Ablaykhan Str., Astana City 010000, Kazakhstan.
authors.forename: A
authors.initials: A
authors.lastname: Dossakhanov
authors.affiliation: ISC 'National Medical Research Center', 42 Ablaykhan Str., Astana City 010000, Kazakhstan.
authors.forename: M
authors.initials: M
authors.lastname: Kozhakbayeva
authors.affiliation: Research Institute for Biology and Medicine Hiroshima University, 1-2-3 Kasumi, Hinamiku, Hiroshima 134-8553, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hoshi
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002386:Cataract / Q000209:etiology* / Q000473:pathology; D047852:Chernobyl Nuclear Accident; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000528:radiation effects*; D007962:Leukocytes / Q000473:pathology* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D055848:Nuclear Power Plants; D016273:Occupational Exposure / Q000009:adverse effects*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology; D055815:Young Adult