title: Angiogenesis, inflammation, platelets count, and metastatic status as a predictor for thrombosis risk in nasopharyngeal carcinoma patients.
abstract: OBJECTIVE
  to assess the use of of angiogenesis, inflammation, platelets count, and metastatic status as predictors for thrombosis risk represented by soluble P-selectin level in nasopharyngeal carcinoma (NPC) patients.
  
  
  METHODS
  a cross sectional study was conducted on NPC patients at the Hematology and Oncology Clinic of Cipto Mangunkusumo Hospital, Jakarta, during Mei to October 2012. Data regarding angiogenesis (CD105 and VEGFR-2), inflammation (IL-6), platelets count, and metastatic status were assessed at enrollment, as well as soluble P-selectin levels in all eligible patients. Bivariate analysis continued with multiple linear regression analysis were done to identify independent predictors for soluble P-selectin levels.
  
  
  RESULTS
  sixty NPC patients were enrolled in the study. There was correlation between platelet counts (r=0.389; p=0.002), IL-6 (r=0.595; p<0.001) and number of metastatic sites (r=0.542; p<0.001) with soluble P-selectin level, and a linear regression analysis showed that these three variables can predict soluble P-selectin levels with adjusted R-square 65%. There was no correlation between VEGFR-2 and CD105 levels with soluble P-selectin levels.
  
  
  CONCLUSIONS
  platelet counts, IL-6 level, and number of sites of metastasis can be used as predictors of soluble P-selectin level as parameter of thrombosis risk in NPC patients.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
authors.forename: Aru W
authors.initials: AW
authors.lastname: Sudoyo
authors.forename: Andhika
authors.initials: A
authors.lastname: Rachman
authors.forename: Kuntjoro
authors.initials: K
authors.lastname: Harimurti
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood; D002277:Carcinoma; D003430:Cross-Sectional Studies; D000071063:Endoglin; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000150:complications*; D009362:Neoplasm Metastasis; D019007:P-Selectin / Q000097:blood; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000097:blood; D012307:Risk Factors; D013927:Thrombosis / Q000150:complications* / Q000517:prevention & control; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000097:blood; D055815:Young Adult
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; C508600:IL6 protein, human; D015850:Interleukin-6; D019007:P-Selectin; D011956:Receptors, Cell Surface; C000588866:KDR protein, human; D040301:Vascular Endothelial Growth Factor Receptor-2