title: Occupational toxic epidermal necrolysis associated with dalbergia cochinchinensis: a retrospective comparative study of eight cases in China.
abstract: BACKGROUND
  Occupational toxic epidermal necrolysis (TEN) related to Dalbergia cochinchinensis has seldom been reported in the past. Its clinical characteristic needs to be investigated. This study reports eight cases of such disease in China.
  
  
  METHODS
  Eight patients with occupational TEN admitted from 2003 to 2012 were retrospectively analyzed and compared with 15 patients admitted with TEN caused by drugs as controls. Patients all received combination therapy of corticosteroid and intravenous immunoglobulin. The times for bullous ceasing, tapering of corticosteroid, and total hospitalization were compared between the two groups of patients. SCORTEN, a severity-of-illness scoring system for TEN prognosis, was applied to evaluate clinical outcome.
  
  
  RESULTS
  The three time measurements in occupational TEN were longer than those in control, and the differences were statistically significant (P = 0.0023, 0.026, 0.0017), which means the total dose of corticosteroid needed in occupational TEN was higher than that in the control. There were no deaths in the two groups, although expected deaths were 0.612 and 0.836, respectively.
  
  
  CONCLUSIONS
  Occupational TEN has a longer progression than TEN caused by drugs, and there is more difficulty in its treatment. Clinicians should pay attention to this disease. However, its mechanism and target therapy remain unclear.
authors.affiliation: Affiliated Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Affiliated Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Affiliated Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Xiaonian
authors.initials: X
authors.lastname: Lu
authors.affiliation: Affiliated Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Affiliated Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Affiliated Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: Affiliated Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Xu
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D035782:Dalbergia / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D007374:Interior Design and Furnishings; D008297:Male; D066192:Manufacturing Industry; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009784:Occupational Diseases / Q000209:etiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy* / Q000209:etiology*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D008775:Methylprednisolone