title: Endocrine therapy in breast cancer: the neoadjuvant, adjuvant, and metastatic approach.
abstract: OBJECTIVE
  To review the rationale for endocrine therapy in the neoadjuvant, adjuvant, and metastatic breast cancer setting and to highlight clinical considerations unique to this treatment.
  
  
  METHODS
  Contemporary literature, clinical guidelines, and national statistics.
  
  
  CONCLUSIONS
  Endocrine therapy represents an important strategy in the management of both early and advanced hormone positive breast cancer. Additional research is required to better define the role of neoadjuvant therapy and the optimal duration of treatment.
  
  
  CONCLUSIONS
  Nurses play a pivotal role in the identification and management of endocrine therapy-associated symptoms. Prompt symptom intervention may improve therapy adherence and ultimately, may improve long-term disease outcomes.
authors.forename: Raquel E
authors.initials: RE
authors.lastname: Reinbolt
authors.forename: Neha
authors.initials: N
authors.lastname: Mangini
authors.forename: Jordan L
authors.initials: JL
authors.lastname: Hill
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Levine
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Dempsey
authors.forename: Janani
authors.initials: J
authors.lastname: Singaravelu
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Koehler
authors.forename: Allison
authors.initials: A
authors.lastname: Talley
authors.forename: Maryam B
authors.initials: MB
authors.lastname: Lustberg
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000451:nursing*; D017024:Chemotherapy, Adjuvant / Q000451:nursing*; D004703:Endocrine System / Q000187:drug effects; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy; D009859:Oncology Nursing / Q000379:methods*; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D013629:Tamoxifen
keywords: Endocrine therapy; aromatase inhibitors; breast cancer; tamoxifen