title: Collaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis.
abstract: Although inflammation and metastasis are two well-known hallmarks of malignant disease, the relationship between inflammation and lymphatic metastasis is an unexplored research area. We recently elucidated a sophisticated mechanism by which TNFα-induced tumor inflammation conscripts macrophage-mediated VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis.
authors.affiliation: Department of Microbiology; Tumor and Cell Biology; Karolinska Institute ; Stockholm, Sweden.
authors.forename: Renhai
authors.initials: R
authors.lastname: Cao
authors.affiliation: Department of Microbiology; Tumor and Cell Biology; Karolinska Institute ; Stockholm, Sweden.
authors.forename: Hong
authors.initials: H
authors.lastname: Ji
authors.affiliation: Department of Microbiology; Tumor and Cell Biology; Karolinska Institute ; Stockholm, Sweden.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Microbiology; Tumor and Cell Biology; Karolinska Institute ; Stockholm, Sweden ; Department of Medicine and Health Sciences; Linköping University ; Linköping, Sweden ; Department of Cardiovascular Sciences; University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Unit; Glenfield Hospital ; Leicester, UK.
authors.forename: Yihai
authors.initials: Y
authors.lastname: Cao
keywords: TNF-α; inflammation; lymphangiogenesis; macrophage; metastasis