title: [Role of brain lipid sensing in nervous regulation of energy balance].
abstract: Fatty acid sensitive neurons located in hypothalamus, hippocampus or striatum are able to detect daily variations of plasma fatty acid levels. Thus, these neurons play a role to regulate energy balance by controling food intake, insulin secretion or hepatic glucose production. Molecular mechanisms that mediate fatty acid effects include receptor FAT (fatty acid transporter)/CD36. Deregulation of this brain lipid sensing may be an early event leading to further dysfunction of energy balance leading to obesity and type 2 diabetes.
authors.affiliation: CNRS UMR 8251, biologie fonctionnelle et adaptative, Paris, France - Université Paris Diderot, 4, rue Marie-Andrée Lagroua Weill-Halle, 75205 Paris Cedex 13, France.
authors.forename: Valentine S
authors.initials: VS
authors.lastname: Moullé
authors.affiliation: CNRS UMR 8251, biologie fonctionnelle et adaptative, Paris, France - Université Paris Diderot, 4, rue Marie-Andrée Lagroua Weill-Halle, 75205 Paris Cedex 13, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Picard
authors.affiliation: CNRS UMR 8251, biologie fonctionnelle et adaptative, Paris, France - Université Paris Diderot, 4, rue Marie-Andrée Lagroua Weill-Halle, 75205 Paris Cedex 13, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Cansell
authors.affiliation: CNRS UMR 8251, biologie fonctionnelle et adaptative, Paris, France - Université Paris Diderot, 4, rue Marie-Andrée Lagroua Weill-Halle, 75205 Paris Cedex 13, France.
authors.forename: Serge
authors.initials: S
authors.lastname: Luquet
authors.affiliation: CNRS UMR 8251, biologie fonctionnelle et adaptative, Paris, France - Université Paris Diderot, 4, rue Marie-Andrée Lagroua Weill-Halle, 75205 Paris Cedex 13, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Magnan
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D050356:Lipid Metabolism / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter