title: Effect of Dietary Resistant Starch on Prevention and Treatment of Obesity-related Diseases and Its Possible Mechanisms.
abstract: Overweight or obesity has become a serious public health problem in the world, scientists are concentrating their efforts on exploring novel ways to treat obesity. Nowadays, the availabilities of bariatric surgery and pharmacotherapy have enhanced obesity treatment, but it should has support from diet, physical exercise and lifestyle modification, especially the functional food. Resistant starch, an indigestible starch, has been studied for years for its beneficial effects on regulating blood glucose level and lipid metabolism. The aim of this review is to summarize the effect of resistant starch on weight loss and the possible mechanisms. According to numerous previous studies it could be concluded that resistant starch can reduce fat accumulation, enhance insulin sensitivity, regulate blood glucose level and lipid metabolism. Recent investigations have focused on the possible associations between resistant starch and incretins as well as gut microbiota. Resistant starch seems to be a promising dietary fiber for the prevention or treatment of obesity and its related diseases.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabeties Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Department of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabeties Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, China.
authors.forename: Hua Ting
authors.initials: HT
authors.lastname: Li
authors.affiliation: Department of Clinical Nutrition, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabeties Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, China.
authors.forename: Qi Chen
authors.initials: QC
authors.lastname: Fang
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabeties Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Department of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Ling Ling
authors.initials: LL
authors.lastname: Qian
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabeties Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, China; Department of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Wei Ping
authors.initials: WP
authors.lastname: Jia
mesh_terms: D004040:Dietary Carbohydrates / Q000378:metabolism; D004043:Dietary Fiber / Q000378:metabolism / Q000627:therapeutic use; D041981:Gastrointestinal Tract / Q000382:microbiology / Q000502:physiology*; D064307:Microbiota; D009765:Obesity / Q000178:diet therapy* / Q000517:prevention & control*; D013213:Starch / Q000378:metabolism*; D015431:Weight Loss
chemical_list: D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D013213:Starch