title: Coencapsulation of Ferulic and Gallic acid in hp-b-cyclodextrin.
abstract: The complexes formed by two polyphenols, trans-Ferulic acid (FA) and Gallic acid (GA) with 2-hydroxypropyl-b-cyclodextrin (HPβCD), by the spray-drying method, were studied. Encapsulation-efficiencies (EE) of the complexes prepared were evaluated by HPLC. In the case of co-encapsulation, the EE of GA was lowered, whereas that of FA was almost stable, indicating a possible antagonistic relationship between the two phenols for the HPβCD cavity. The physicochemical characterization of the complexes was carried out by Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM). SEM observations revealed that the coencapsulated phenolic complex resulted in a more rounded shape outer surfaces of HPβCD than when encapsulated separately. FT-IR and DSC data indicated that the two polyphenols exhibit a possible interaction in the coencapsulated complex. The complexes showed no loss of their ability to scavenge DPPH radical relatively to the single agent at the concentrations used.
authors.affiliation: Department of Food Technology, Technological Educational Institution of Thessaly, Terma N. Temponera Str., 43100 Karditsa, Greece. Electronic address: ogortzi@teilar.gr.
authors.forename: Gortzi
authors.initials: G
authors.lastname: Olga
authors.affiliation: Department of Food Technology, Technological Educational Institution of Thessaly, Terma N. Temponera Str., 43100 Karditsa, Greece.
authors.forename: Christophoridou
authors.initials: C
authors.lastname: Styliani
authors.affiliation: Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, Ioannina 45110, Greece.
authors.forename: Roussis G
authors.initials: RG
authors.lastname: Ioannis
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D001713:Biphenyl Compounds / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D003373:Coumaric Acids / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D005707:Gallic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010851:Picrates / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D003373:Coumaric Acids; D010851:Picrates; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D005707:Gallic Acid; C004999:ferulic acid; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: 2-Hydroxypropyl-b-cyclodextrin; Encapsulation; Ferulic acid; Gallic acid; Spray drying