title: Mean platelet volume as a novel predictor of systemic inflammatory response in cirrhotic patients with culture-negative neutrocytic ascites.
abstract: OBJECTIVE
  To identify a mean platelet volume (MPV) cutoff value which should be able to predict the presence of bacterial infection.
  
  
  METHODS
  An observational, analytic, retrospective study. We evaluated medical records of cirrhotic patients who were hospitalized from January 2012 to January 2014 at the Gastroenterology Department of "Hospital General de México Dr. Eduardo Liceaga", we included 51 cirrhotic patients with ascites fluid infection (AFI), and 50 non-infected cirrhotic patients as control group. Receiver operator characteristic curves were used to identify the best cutoff value of several parameters from hematic cytometry, including MPV, to predict the presence of ascites fluid infection.
  
  
  RESULTS
  Of the 51 cases with AFI, 48 patients (94.1%) had culture-negative neutrocytic ascites (CNNA), 2 (3.9%) had bacterial ascites, and one (2%) had spontaneous bacterial peritonitis. Infected patients had greater count of leucocytes and polymorphonuclear cells, greater levels of MPV and cardiac frequency (P < 0.0001), and lower mean arterial pressure compared with non-infected patients (P = 0.009). Leucocytes, polymorphonuclear count, MPV and cardiac frequency resulted to be good or very good predictive variables of presence of AFI in cirrhotic patients (area under the receiving operating characteristic > 0.80). A cutoff MPV value of 8.3 fl was the best to discriminate between cirrhotic patients with AFI and those without infection.
  
  
  CONCLUSIONS
  Our results support that MPV can be an useful predictor of systemic inflammatory response syndrome in cirrhotic patients with AFI, particularly CNNA.
authors.affiliation: Marisol Gálvez-Martínez, Eduardo Pérez-Torres, Francisco Salas-Gordillo, Fátima Higuera-de la Tijera, Gastroenterology Department, Hospital General de México "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.
authors.forename: Marisol
authors.initials: M
authors.lastname: Gálvez-Martínez
authors.affiliation: Marisol Gálvez-Martínez, Eduardo Pérez-Torres, Francisco Salas-Gordillo, Fátima Higuera-de la Tijera, Gastroenterology Department, Hospital General de México "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.
authors.forename: Alfredo I
authors.initials: AI
authors.lastname: Servín-Caamaño
authors.affiliation: Marisol Gálvez-Martínez, Eduardo Pérez-Torres, Francisco Salas-Gordillo, Fátima Higuera-de la Tijera, Gastroenterology Department, Hospital General de México "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Pérez-Torres
authors.affiliation: Marisol Gálvez-Martínez, Eduardo Pérez-Torres, Francisco Salas-Gordillo, Fátima Higuera-de la Tijera, Gastroenterology Department, Hospital General de México "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.
authors.forename: Francisco
authors.initials: F
authors.lastname: Salas-Gordillo
authors.affiliation: Marisol Gálvez-Martínez, Eduardo Pérez-Torres, Francisco Salas-Gordillo, Fátima Higuera-de la Tijera, Gastroenterology Department, Hospital General de México "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.
authors.forename: Xaira
authors.initials: X
authors.lastname: Rivera-Gutiérrez
authors.affiliation: Marisol Gálvez-Martínez, Eduardo Pérez-Torres, Francisco Salas-Gordillo, Fátima Higuera-de la Tijera, Gastroenterology Department, Hospital General de México "Dr. Eduardo Liceaga", Mexico City 06720, Mexico.
authors.forename: Fátima
authors.initials: F
authors.lastname: Higuera-de la Tijera
keywords: Ascites fluid infection; Cirrhosis; Culture negative neutrocytic ascites; Mean platelet volume; Systemic inflammatory response