title: Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs.
abstract: Liao et al. (2015) recently reported on the effects of disrupting DNA methyltransferase activity in human embryonic stem cells (hESCs). This work highlights key differences between mammalian ESC models upon the loss of these essential proteins and provides comprehensive base resolution methylome maps of DNMT targets during human development.
authors.affiliation: ARC Center of Excellence in Plant Energy Biology, The University of Western Australia, Perth, WA 6009, Australia; The Harry Perkins Institute of Medical Research, Perth, WA 6009, Australia.
authors.forename: Ozren
authors.initials: O
authors.lastname: Bogdanović
authors.affiliation: ARC Center of Excellence in Plant Energy Biology, The University of Western Australia, Perth, WA 6009, Australia; The Harry Perkins Institute of Medical Research, Perth, WA 6009, Australia. Electronic address: ryan.lister@uwa.edu.au.
authors.forename: Ryan
authors.initials: R
authors.lastname: Lister
mesh_terms: D000818:Animals; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics*; D019175:DNA Methylation; D053595:Embryonic Stem Cells / Q000201:enzymology*; D006801:Humans
chemical_list: D004248:DNA (Cytosine-5-)-Methyltransferases