title: Structural biology of bacterial RNA polymerase.
abstract: Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA polymerase. J. Biol. Chem. 2005, 280, 42477-42485), an enormous amount of biochemical, biophysical and genetic data has been collected on bacterial RNA polymerase (RNAP). In the late 1990s, structural information pertaining to bacterial RNAP has emerged that provided unprecedented insights into the function and mechanism of RNA transcription. In this review, I list all structures related to bacterial RNAP (as determined by X-ray crystallography and NMR methods available from the Protein Data Bank), describe their contributions to bacterial transcription research and discuss the role that small molecules play in inhibiting bacterial RNA transcription.
authors.affiliation: Department of Biochemistry and Molecular Biology, The Center for RNA Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA. kum14@psu.edu.
authors.forename: Katsuhiko S
authors.initials: KS
authors.lastname: Murakami
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008969:Molecular Sequence Data
chemical_list: D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D012321:DNA-Directed RNA Polymerases
keywords: NMR; X-ray crystallography; anti-σ factor; bacterial RNA polymerase; core enzyme; holoenzyme; inhibitor antibiotic; transcription; transcription factor; σ factor