title: Basophils in inflammation.
abstract: Basophils are functionally closely related to mast cells. Both cell types express the high-affinity IgE receptor (FcεRI) and rapidly release preformed mediator from intracellular stores upon IgE-mediated activation. However, in contrast to mast cells basophils finish their maturation in the bone marrow and have a lifespan of only 2-3 days. Basophil numbers increase in response to IL-3 or TSLP and migrate into tissues to promote type 2 immune responses. Here we review recent advances regarding the pro- and anti-inflammatory functions of basophils in murine models and human allergic inflammation of the skin, lung and intestine.
authors.affiliation: Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Schwartz
authors.affiliation: Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany.
authors.forename: Joerg U
authors.initials: JU
authors.lastname: Eberle
authors.affiliation: Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany. Electronic address: david.voehringer@uk-erlangen.de.
authors.forename: David
authors.initials: D
authors.lastname: Voehringer
mesh_terms: D000818:Animals; D001491:Basophils / Q000166:cytology* / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D009928:Organ Specificity
keywords: Allergic asthma; Anaphylaxis; Atopic dermatitis; Basophils; Food allergy