title: Cytoskeletal dynamics: a view from the membrane.
abstract: Many aspects of cytoskeletal assembly and dynamics can be recapitulated in vitro; yet, how the cytoskeleton integrates signals in vivo across cellular membranes is far less understood. Recent work has demonstrated that the membrane alone, or through membrane-associated proteins, can effect dynamic changes to the cytoskeleton, thereby impacting cell physiology. Having identified mechanistic links between membranes and the actin, microtubule, and septin cytoskeletons, these studies highlight the membrane's central role in coordinating these cytoskeletal systems to carry out essential processes, such as endocytosis, spindle positioning, and cellular compartmentalization.
authors.affiliation: Department of Biology, University of Massachusetts Amherst, Amherst, MA 01003 bezanilla@bio.umass.edu.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Bezanilla
authors.affiliation: Department of Biological Sciences, Dartmouth College, Hanover, NH 03755.
authors.forename: Amy S
authors.initials: AS
authors.lastname: Gladfelter
authors.affiliation: Department of Molecular Genetics and Cell Biology and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637 Department of Molecular Genetics and Cell Biology and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637.
authors.forename: David R
authors.initials: DR
authors.lastname: Kovar
authors.affiliation: Department of Biology, University of Massachusetts Amherst, Amherst, MA 01003.
authors.forename: Wei-Lih
authors.initials: WL
authors.lastname: Lee
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D058112:Septins / Q000378:metabolism*; D008941:Spindle Apparatus / Q000378:metabolism*
chemical_list: D058112:Septins