title: The role of long non-coding RNAs in genome formatting and expression.
abstract: Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization, transcriptional regulation, and post-transcriptional control. Misregulation of lncRNAs expression has been found to be associated to cancer and other human disorders. Here, we review the different types of lncRNAs, their mechanisms of action on genome formatting and expression and emphasized on the multifaceted action of the H19 lncRNA.
authors.affiliation: Cell Plasticity and Cancer - Inserm U908, University of Lille Lille, France.
authors.forename: Pierre-Olivier
authors.initials: PO
authors.lastname: Angrand
authors.affiliation: Cell Plasticity and Cancer - Inserm U908, University of Lille Lille, France.
authors.forename: Constance
authors.initials: C
authors.lastname: Vennin
authors.affiliation: Cell Plasticity and Cancer - Inserm U908, University of Lille Lille, France.
authors.forename: Xuefen
authors.initials: X
authors.lastname: Le Bourhis
authors.affiliation: Cell Plasticity and Cancer - Inserm U908, University of Lille Lille, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Adriaenssens
keywords: H19; chromatin organization; lncRNAs; post-transcriptional control; transcriptional regulation