title: [Non- PSA serum markers for the diagnosis of PCa].
abstract: Prostate cancer (PCa) is the most common male malignancy in our population. Over the past two decades, the prostate specific antigen (PSA) has been widely used for screening, diagnosis and monitoring of prostate cancer. Routine use of PSA has been continuing subject to controversy due to its limited specificity, which is derived from the fact that serum PSA levels are produced in a variety of non-neoplastic conditions. The shortcomings in sensitivity and specificity of PSA have promoted the search for new biomarkers to improve diagnostic performance. The ultimate goal is to get those diagnosing clinically significant prostate tumors and to individualize treatment in this disease. Among the biomarkers studied in prostate cancer we could found tissue biomarkers as well as serum or urine biomarkers. In this paper we proceed to review those serum biomarkers not related to PSA that have been published in the literature.
authors.affiliation: Laboratorio de Biología Molecular. Hospital Clínic de Barcelona. España.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Mengual
authors.affiliation: Servicio de Urología. Hospital Clínic. Universitat de Barcelona. España.
authors.forename: Mireia
authors.initials: M
authors.lastname: Musquera
authors.affiliation: Servicio de Urología. Hospital Clínic. Universitat de Barcelona. España. Servicio de Urología. Hospital de Mollet. Barcelona. España.
authors.forename: Alexandru
authors.initials: A
authors.lastname: Ciudin
authors.affiliation: Laboratorio de Biología Molecular. Hospital Clínic de Barcelona. España. Servicio de Urología. Hospital Clínic. Universitat de Barcelona. España.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Ribal
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D006801:Humans; D008297:Male; D009696:Nucleic Acids / Q000097:blood; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D001798:Blood Proteins; D009696:Nucleic Acids; D017430:Prostate-Specific Antigen