title: Serum paraoxonase and arylesterase activities in patients with chronic otitis media.
abstract: OBJECTIVE
  Paraoxonase-1 (PON1) prevents oxidative stress by inhibiting the oxidation of cell membrane lipids by the reactive oxygen species that form during acute and chronic inflammation. The aim of this study was to investigate serum PON1 activity and oxidative stress in patients with chronic otitis media (COM).
  
  
  METHODS
  Fifty consecutive patients with COM and 55 controls were enrolled in the present study. The patients were divided into two groups according to the presence of cholesteatoma. The serum PON1 arylesterase activities and lipid hydroperoxide (LOOH) levels were determined.
  
  
  RESULTS
  Serum paraoxonase and arylesterase activities were significantly lower in the COM patients than in the controls (P < 0.001 for all comparisons), whereas the LOOH levels were significantly higher (P < 0.001).
  
  
  CONCLUSIONS
  These results indicated that a lower level of PON1 activity was associated with an oxidant-antioxidant imbalance. In addition, decreased PON1 activity may play an important role in the pathophysiology of COM.
authors.forename: Mahfuz
authors.initials: M
authors.lastname: Turan
authors.forename: Rıfkı
authors.initials: R
authors.lastname: Ucler
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Ferhat
authors.initials: F
authors.lastname: Kalkan
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskın
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Garca
authors.forename: Hakan
authors.initials: H
authors.lastname: Cankaya
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000737:chemistry; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D016022:Case-Control Studies; D002462:Cell Membrane / Q000378:metabolism; D002781:Cholesteatoma / Q000378:metabolism; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D007249:Inflammation; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008055:Lipids / Q000737:chemistry; D008297:Male; D010033:Otitis Media / Q000097:blood*; D016877:Oxidants / Q000737:chemistry; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D008055:Lipids; D016877:Oxidants; D006861:Hydrogen Peroxide; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Cholesteatoma; Chronic otitis media; Lipid hydroperoxide; PON1 activity