title: Radiosurgery or Fractionated Stereotactic Radiotherapy plus Whole-brain Radioherapy in Brain Oligometastases: A Long-term Analysis.
abstract: OBJECTIVE
  To analyze the outcome of patients with brain oligometastases treated by radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) after whole-brain radiotherapy (WBRT).
  
  
  METHODS
  Overall survival (OS) and local control (LC) were evaluated in patients (patients) with 1-2 brain metastases.
  
  
  RESULTS
  Forty-seven patients were selected. They were submitted to WBRT (median dose=3,750 cGy) followed by SRS (17 patients; median dose=1,500 cGy) or FSRT (30 patients; median dose=2,000 cGy). Median follow-up was 102 months (range=17-151); the median survival was 22 months for the SRS group and 16 months for the FSRT group. One-year and 5-year survival was 56% and 16%, respectively, in SRT and 62.1% and 3%, respectively, in FSRT. Neither treatment proved to significantly impact OS (p=0.4). The 1-year LC rates were 80% and 61.1% in the two groups, respectively (p=0.15).
  
  
  CONCLUSIONS
  SRS or FSRT after WBRT could offer the same outcomes in patients with brain oligometasteses. Further investigation is warranted to confirm these data and define the optimal stereotactic modality.
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Balducci
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy rosa_autorino@yahoo.it.
authors.forename: Rosa
authors.initials: R
authors.lastname: Autorino
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Chiesa
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Mattiucci
authors.affiliation: Department of Neurosurgery, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Pompucci
authors.affiliation: Department of Physics, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Azario
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Giuseppe Roberto
authors.initials: GR
authors.lastname: D'Agostino
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Milena
authors.initials: M
authors.lastname: Ferro
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Alba
authors.initials: A
authors.lastname: Fiorentino
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Fersino
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Ciro
authors.initials: C
authors.lastname: Mazzarella
authors.affiliation: Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Cesare
authors.initials: C
authors.lastname: Colosimo
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Frascino
authors.affiliation: Department of Neurosurgery, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Anile
authors.affiliation: Department of Radiation Oncology, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Valentini
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011379:Prognosis; D011829:Radiation Dosage; D016634:Radiosurgery / Q000379:methods*; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: Brain oligometastases; RPA; fractionation; stereotactic radiotherapy; whole brain radiotherapy