title: Detailed clinical modelling approach to data extraction from heterogeneous data sources for clinical research.
abstract: The reuse of routinely collected clinical data for clinical research is being explored as part of the drive to reduce duplicate data entry and to start making full use of the big data potential in the healthcare domain. Clinical researchers often need to extract data from patient registries and other patient record datasets for data analysis as part of clinical studies. In the TRANSFoRm project, researchers define their study requirements via a Query Formulation Workbench. We use a standardised approach to data extraction to retrieve relevant information from heterogeneous data sources, using semantic interoperability enabled via detailed clinical modelling. This approach is used for data extraction from data sources for analysis and for pre-population of electronic Case Report Forms from electronic health records in primary care clinical systems.
authors.affiliation: Institute of Digital Healthcare, WMG, University of Warwick, UK.
authors.forename: Sarah N
authors.initials: SN
authors.lastname: Lim Choi Keung
authors.affiliation: Institute of Digital Healthcare, WMG, University of Warwick, UK.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Institute of Digital Healthcare, WMG, University of Warwick, UK.
authors.forename: James
authors.initials: J
authors.lastname: Rossiter
authors.affiliation: Health Informatics Centre, University of Dundee, UK.
authors.forename: Mark
authors.initials: M
authors.lastname: McGilchrist
authors.affiliation: Health Informatics Centre, University of Dundee, UK.
authors.forename: Frank
authors.initials: F
authors.lastname: Culross
authors.affiliation: INSERM UMR_S 872, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Ethier
authors.affiliation: INSERM UMR_S 872, France.
authors.forename: Anita
authors.initials: A
authors.lastname: Burgun
authors.affiliation: NIVEL Netherlands Institute for Health Services Research, The Netherlands.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Verheij
authors.affiliation: NIVEL Netherlands Institute for Health Services Research, The Netherlands.
authors.forename: Nasra
authors.initials: N
authors.lastname: Khan
authors.affiliation: Department of Primary Care and Health Sciences, King's College London, UK.
authors.forename: Adel
authors.initials: A
authors.lastname: Taweel
authors.affiliation: Department of Computing, Imperial College London, UK.
authors.forename: Vasa
authors.initials: V
authors.lastname: Curcin
authors.affiliation: Department of Primary Care and Health Sciences, King's College London, UK.
authors.forename: Brendan C
authors.initials: BC
authors.lastname: Delaney
authors.affiliation: Institute of Digital Healthcare, WMG, University of Warwick, UK.
authors.forename: Theodoros N
authors.initials: TN
authors.lastname: Arvanitis