title: [Effect of acupuncture along affected meridian on the MME gene expression of migraine patients without aura of gan-yang hyperactivity syndrome].
abstract: OBJECTIVE
  To observe the effect of acupuncture along affected meridian on the mem- brane metallo-endopeptidase (MME) gene expression of migraine patients without aura (MO) of Gan-yang hyperactivity syndrome (GYHS).
  
  
  METHODS
  Totally 20 MO patients of GYHS were randomly assigned to the acupoint group (acupuncture along affected meridian) and the non-acupoint group, 10 cases in each group. Needling was performed once per day for 10 consecutive days. Gene chip technology was used to obtain two sets of gene expression profiles and analyzed using Gene Ontology (GO).
  
  
  RESULTS
  In the acupoint group, MME gene expression decreased after needling (P = 0.0023).That gene was rich in the beta-amyloid metabolic process (P = 3.16E-05) and the peptide metabolic process (P = 0.009612). Its expression was not seen in the non-acupoint group.
  
  
  CONCLUSIONS
  The effect of point selection along affected meridian could be achieved possibly by regulating the MME gene expression.
authors.forename: Yin-Lan
authors.initials: YL
authors.lastname: Huang
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Wan
authors.forename: Xi-Sen
authors.initials: XS
authors.lastname: Liang
authors.forename: Fan-Rong
authors.initials: FR
authors.lastname: Liang
mesh_terms: D026881:Acupuncture; D015669:Acupuncture Points; D015670:Acupuncture Therapy; D004732:Endrin / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D016740:Meridians; D008881:Migraine Disorders / Q000628:therapy*; D013577:Syndrome
chemical_list: C020415:MME; D004732:Endrin