title: Unexpected lateral-lithiation-induced alkylative ring opening of tetrahydrofurans in deep eutectic solvents: synthesis of functionalised primary alcohols.
abstract: o-Tolyl-substituted tetrahydrofurans undergo highly regioselective ring opening with the concomitant formation of new C-C bonds as the result of a lateral lithiation reaction. This reaction provides a new method for the synthesis of functionalised primary alcohols and can be run directly in protic eutectic mixtures as benign reaction media at 0 °C and under air, competitively with protonolysis.
authors.affiliation: Dipartimento di Farmacia-Scienze del Farmaco, Università di Bari "Aldo Moro", Consorzio C.I.N.M.P.I.S., Via E. Orabona 4, Bari, I-70125, Italy. vito.capriati@uniba.it.
authors.forename: Francesca C
authors.initials: FC
authors.lastname: Sassone
authors.forename: Filippo M
authors.initials: FM
authors.lastname: Perna
authors.forename: Antonio
authors.initials: A
authors.lastname: Salomone
authors.forename: Saverio
authors.initials: S
authors.lastname: Florio
authors.forename: Vito
authors.initials: V
authors.lastname: Capriati
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis*; D005663:Furans / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D000438:Alcohols; D005663:Furans; D012997:Solvents