title: Defect-related luminescent mesoporous silica nanoparticles employed for novel detectable nanocarrier.
abstract: Uniform and well-dispersed walnut kernel-like mesoporous silica nanoparticles (MSNs) with diameters about 100 nm have been synthesized by a templating sol-gel route. After an annealing process, the as-obtained sample (DLMSNs) inherits the well-defined morphology and good dispersion of MSNs, and exhibits bright white-blue luminescence, higher specific surface area and pore volume, and better biocompatibility. The drug loading and release profiles show that DLMSNs have high drug loading capacity, and exhibit an initial burst release followed by a slow sustained release process. Interestingly, the luminescence intensity of the DLMSNs-DOX system increases gradually with the increase of cumulative released DOX, which can be verified by the confocal laser scanning images. The drug carrier DLMSNs can potentially be applied as a luminescent probe for monitoring the drug release process. Moreover, the DLMSNs-DOX system exhibits potent anticancer effect against three kinds of cancer cells (HeLa, MCF-7, and A549 cells).
authors.affiliation: §Affiliated Hospital of Hebei University, Baoding 071000, P. R. China.
authors.forename: Kun
authors.initials: K
authors.lastname: Ge
authors.forename: Cuimiao
authors.initials: C
authors.lastname: Zhang
authors.forename: Guang
authors.initials: G
authors.lastname: Jia
authors.forename: Huihui
authors.initials: H
authors.lastname: Ren
authors.forename: Jianyuan
authors.initials: J
authors.lastname: Wang
authors.forename: Aaron
authors.initials: A
authors.lastname: Tan
authors.affiliation: ∥CAS Key Lab of Nanomaterials Bioeffects and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, P. R. China.
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
authors.affiliation: §Affiliated Hospital of Hebei University, Baoding 071000, P. R. China.
authors.forename: Aimin
authors.initials: A
authors.lastname: Zang
authors.forename: Jinchao
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D008422:Materials Testing; D053769:Nanocapsules / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D058608:Nanopores / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology*; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D000068936:Theranostic Nanomedicine / Q000379:methods
chemical_list: D000903:Antibiotics, Antineoplastic; D053769:Nanocapsules; D012822:Silicon Dioxide; D004317:Doxorubicin
keywords: anticancer effect; defect-related luminescence; drug carrier; mesoporous silica nanoparticles