title: Expanding applications, accuracy, and interpretation of laser speckle contrast imaging of cerebral blood flow.
abstract: Laser speckle contrast imaging (LSCI) provides a rapid characterization of cortical flow dynamics for functional monitoring of the microcirculation. The technique stems from interactions of laser light with moving particles. These interactions encode the encountered Doppler phenomena within a random interference pattern imaged in widefield, known as laser speckle. Studies of neurovascular function and coupling with LSCI have benefited from the real-time characterization of functional dynamics in the laboratory setting through quantification of perfusion dynamics. While the technique has largely been relegated to acute small animal imaging, its scalability is being assessed and characterized for both chronic and clinical neurovascular imaging.
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
authors.forename: S M Shams
authors.initials: SM
authors.lastname: Kazmi
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Richards
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Schrandt
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Davis
authors.affiliation: Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, USA.
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Dunn
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000032:analysis; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation / Q000379:methods*
chemical_list: D003287:Contrast Media