title: Interferon Gamma Prolongs Survival of Varicella-Zoster Virus-Infected Human Neurons In Vitro.
abstract: Infection of human neurons in vitro with varicella-zoster virus (VZV) at a low multiplicity of infection does not result in a cytopathic effect (CPE) within 14 days postinfection (dpi), despite production of infectious virus. We showed that by 28 dpi a CPE ultimately developed in infected neurons and that interferon gamma inhibited not only the CPE but also VZV DNA accumulation, transcription, and virus production, thereby prolonging the life of VZV-infected neurons.
authors.affiliation: Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Nicholas L
authors.initials: NL
authors.lastname: Baird
authors.affiliation: Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Jacqueline L
authors.initials: JL
authors.lastname: Bowlin
authors.affiliation: Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Taylor J
authors.initials: TJ
authors.lastname: Hotz
authors.affiliation: Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Cohrs
authors.affiliation: Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA don.gilden@ucdenver.edu.
authors.forename: Don
authors.initials: D
authors.lastname: Gilden
mesh_terms: D002470:Cell Survival; D003588:Cytopathogenic Effect, Viral; D014645:Herpesvirus 3, Human / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D009474:Neurons / Q000502:physiology* / Q000821:virology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: C573415:IFNG protein, human; D007371:Interferon-gamma