title: Estimation of calcium, magnesium, cadmium, and lead in biological samples from paralyzed quality control and production steel mill workers.
abstract: The determination of trace and toxic metals in the biological samples of human beings is an important clinical screening procedure. The aim of the present study was to compare the level of essential trace and toxic elements cadmium (Cd), calcium (Ca), lead (Pb), and magnesium (Mg) in biological samples (whole blood, urine, and scalp hair) of male paralyzed production (PPW) and quality control workers (PQW) of a steel mill, age ranged (35-55 years). For comparison purposes, healthy age-matched exposed referent subjects (EC), working in steel mill and control subjects (NEC), who were not working in industries and lived far away from the industrial areas, were selected as control subjects. The concentrations of electrolytes and toxic elements in biological samples were measured by atomic absorption spectrometry after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked using certified reference materials. The results of this study showed that the mean values of Cd and Pb were significantly higher in scalp hair, blood, and urine samples of PPW and PQW as compared to NEC and EC (p < 0.001), whereas the concentrations of Ca and Mg were found to be lower in the scalp hair and blood but higher in the urine samples of PPW and PQW. The results show the need for immediate improvements in workplace, ventilation, and industrial hygiene practices.
authors.affiliation: National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan, hassanimranafridi@yahoo.com.
authors.forename: Hassan Imran
authors.initials: HI
authors.lastname: Afridi
authors.forename: Farah Naz
authors.initials: FN
authors.lastname: Talpur
authors.forename: Tasneem Gul
authors.initials: TG
authors.lastname: Kazi
authors.forename: Naveed
authors.initials: N
authors.lastname: Kazi
authors.forename: Sadaf Sadia
authors.initials: SS
authors.lastname: Arain
authors.forename: Faheem
authors.initials: F
authors.lastname: Shah
mesh_terms: D000328:Adult; D002104:Cadmium / Q000032:analysis / Q000378:metabolism*; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D004784:Environmental Monitoring; D006197:Hair / Q000737:chemistry; D000075322:Heavy Metal Poisoning; D006801:Humans; D007854:Lead / Q000032:analysis / Q000378:metabolism*; D008274:Magnesium / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008669:Metallurgy; D016273:Occupational Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D010243:Paralysis / Q000378:metabolism*; D011041:Poisoning; D011786:Quality Control; D012535:Scalp; D013054:Spectrophotometry, Atomic / Q000379:methods; D013232:Steel
chemical_list: D002104:Cadmium; D013232:Steel; D007854:Lead; D008274:Magnesium; D002118:Calcium