title: [Profile of sensitization to allergens in children with atopic dermatitis assisting to Allergology Service of University Hospital, Nuevo Leon, Mexico].
abstract: BACKGROUND
  Sensitization to allergens in atopic dermatitis patients is a risk factor for developing asthma and allergic rhinitis in the future,as well as an aggravating factor in the course of the disease. Recent studies have attributed the activity of the proteases of some antigens to cause a grater defect in the epithelial barrier and a more severe disease.
  
  
  OBJECTIVE
  To know the sensitization to allergens pattern in children with atopic dermatitis attended at Allergology Service of University Hospital of UANL, Mexico, and to know if these children have higher sensitization to antigens with proteolytic activity.
  
  
  METHODS
  A retrospective study was done reviewing the skin prick test reports done in our service to children ranging from 5 months to 16 years old, diagnosed with atopic dermatitis during a period of 2 years, from January 2012 to January 2014. The frequency of sensitization to aeroallergens and food were analyzed as well as the weal size (≥6mm) on the skin in response to each particular allergen in the case of food skin prick test.
  
  
  RESULTS
  Reports of skin tests of 66 children, 30 boys and 36 girls, were included; 37 of children were sensitized to more than one allergen,18/66 had asthma and/or allergic rhinitis, 40/66 60% skin prick tests were positive to high activity protease aeroallergens (Dermatophagoides pteronyssinus/Dermatophagoides farinae). Regarding food, sensitization was seen in 38 children; fruits and vegetables were the two most common foods. Only seven children had skin prick weal bigger than 6 mm, mainly to egg, fish and cow's milk.
  
  
  CONCLUSIONS
  Children with atopic dermatitis are often sensitized to high protease activity aeroallergens, polysensitization is very common and the association with airway allergy is seen early in life. Sensitization to food is also common in these patients, but only a small percentage showed a response large enough to be associated with disease severity.
authors.affiliation: Centro Regional Alergología e Inmunología Clínica (CRAIC), Hospital Universitario, Monterrey, Nuevo León, México. adrianyongrodriguez@me.com.
authors.forename: Adrián
authors.initials: A
authors.lastname: Yong-Rodríguez
authors.forename: Alejandra
authors.initials: A
authors.lastname: Macías-Weinmann
authors.forename: Samuel
authors.initials: S
authors.lastname: Palma-Gómez
authors.forename: Alfredo
authors.initials: A
authors.lastname: Arias-Cruz
authors.forename: Rafael
authors.initials: R
authors.lastname: Pérez-Vanzzini
authors.forename: José Julio
authors.initials: JJ
authors.lastname: Gutiérrez-Mujica
authors.forename: Sandra Nora
authors.initials: SN
authors.lastname: González-Díaz
keywords: Aeroallergen; Atopic dermatitis; Children; Sensitization; Skin prick; Test