title: Diterpenoids and Triterpenoids from the Resin of Bursera microphylla and Their Cytotoxic Activity.
abstract: A chemical study of the nonpolar fraction of a methanol-soluble extract of Bursera microphylla resin yielded a variety of di- and triterpenoids. In total, 15 compounds were isolated, of which three are new, namely, malabaricatrienone (1), malabaricatrienol (2), and microphyllanin (3). The antiproliferative activity of the major compounds was evaluated in different murine cancer cell lines (M12.C3.F6 and RAW264.7) and human cancer cells (A549, HeLa, and PC-3). The new compounds (1-3) did not show significant antiproliferative activity. The known compounds ariensin (4), burseran (5), and dihydroclusin diacetate (6) were effective against the RAW264.7 cell line, with IC50 values in the micromolar range.
authors.affiliation: †Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1-06123 Perugia, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Messina
authors.affiliation: †Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1-06123 Perugia, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Curini
authors.affiliation: ‡Department of Oncohematology, University of Perugia, Santa Maria Hospital, Via Tristano di Joanuccio, 1-05100 Terni, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Di Sano
authors.affiliation: §Department of Pharmaceutical Sciences, University of Perugia, Borgo XX Giugno, 74-06121 Perugia, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Zadra
authors.affiliation: †Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1-06123 Perugia, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Gigliarelli
authors.affiliation: ⊥Department of Chemical and Biological Science, University of Sonora, Hermosillo, Sonora, Mexico.
authors.forename: Luisa Alondra
authors.initials: LA
authors.lastname: Rascón-Valenzuela
authors.affiliation: ⊥Department of Chemical and Biological Science, University of Sonora, Hermosillo, Sonora, Mexico.
authors.forename: Ramón Enrique
authors.initials: RE
authors.lastname: Robles Zepeda
authors.affiliation: †Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo, 1-06123 Perugia, Italy.
authors.forename: Maria Carla
authors.initials: MC
authors.lastname: Marcotullio
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031233:Bursera / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D017705:Lignans / Q000494:pharmacology; D008800:Mexico; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D012116:Resins, Plant / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D005663:Furans; D017705:Lignans; D010936:Plant Extracts; D012116:Resins, Plant; D014315:Triterpenes; C431245:burseran