title: Synthesis and immunological study of α-2,9-oligosialic acid conjugates as anti-group C meningitis vaccines.
abstract: α-2,9-Di-, tri-, tetra-, and pentasialic acids were prepared and conjugated with a carrier protein. The resultant glycoconjugates elicited robust T cell-mediated immunity in mice. α-2,9-Trisialic acid was identified as a promising antigen for developing glycoconjugate vaccines against group C Neisseria meningitidis.
authors.affiliation: Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA. zwguo@chem.wayne.edu.
authors.forename: Guochao
authors.initials: G
authors.lastname: Liao
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Zhongwu
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000138:chemical synthesis / Q000494:pharmacology*; D006001:Glycoconjugates / Q000138:chemical synthesis / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000276:immunology; D008585:Meningitis, Meningococcal / Q000276:immunology / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D009345:Neisseria meningitidis / Q000187:drug effects / Q000276:immunology*; D012794:Sialic Acids / Q000737:chemistry*; D018074:Vaccines, Conjugate / Q000494:pharmacology*
chemical_list: D001428:Bacterial Vaccines; D006001:Glycoconjugates; D007074:Immunoglobulin G; D022401:Meningococcal Vaccines; D012794:Sialic Acids; D018074:Vaccines, Conjugate