title: Comparison of everolimus- and paclitaxel-eluting stents in dialysis patients.
abstract: BACKGROUND
  We previously reported that the incidence of 1-year major adverse cardiac events (MACE) in patients treated with paclitaxel-eluting stents (PES) was lower than that in the sirolimus-eluting stents in dialysis patients. However, it remains unclear whether there are differences in clinical outcomes between everolimus-eluting stents (EES) and PES.
  
  
  METHODS
  Between February 2010 and September 2013, 102 maintenance dialysis patients with 135 lesions treated with EES were compared to 107 maintenance dialysis patients with 147 lesions treated with PES. One-year clinical outcomes were investigated.
  
  
  RESULTS
  Diabetes mellitus was present in 64.7% in the EES group and 71.0% in the PES group (p = 0.33). Heavy calcification was in 27.4% vs. 34.0% (p = 0.23). Rotational atherectomy was undergone in 11.1% vs. 23.1% (p < 0.01). Total stented length was not significantly different (23.5 ± 14.6 mm vs. 24.4 ± 13.2 mm, p = 0.60). One patient in the EES group was lost to follow up. At 12 months, MACE occurred in 13.2% in the EES group and 17.4% in the PES group (p = 0.25). Target lesion revascularization (TLR) was observed in 9.5% vs. 10.4% respectively (p = 0.77). Mortality was 11.8% vs. 13.1% (p = 0.35). Cardiac death was 5.0% vs. 7.7% (p = 0.09). Definite stent thrombosis was observed in 2.0% vs. 0% (p = 0.14). Subgroup analysis in patients with diabetes mellitus revealed no significant differences in MACE (12.7% vs. 14.9%, p = 0.36), TLR (8.3% vs. 7.4%, p = 0.42), mortality (13.7% vs. 13.2%, p = 0.28), and cardiac death (6.3% vs. 8.0%, p = 0.15) between the two groups.
  
  
  CONCLUSIONS
  One-year clinical outcomes following EES and PES implantations are similar in dialysis patients.
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan. Electronic address: Masaya.Otsuka@ma7.seikyou.ne.jp.
authors.forename: Masaya
authors.initials: M
authors.lastname: Otsuka
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Shiode
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Masaoka
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Okimoto
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Tamekiyo
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Kawase
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yamane
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Kagawa
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Hironobe
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Tasuku
authors.initials: T
authors.lastname: Higashihara
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Yuto
authors.initials: Y
authors.lastname: Fujii
authors.affiliation: Division of Cardiology, Cardiovascular Center, Akane Foundation Tsuchiya General Hospital, Hiroshima, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D023903:Coronary Restenosis / Q000188:drug therapy; D054855:Drug-Eluting Stents; D000068338:Everolimus / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000517:prevention & control; D017239:Paclitaxel / Q000627:therapeutic use*; D006435:Renal Dialysis; D016896:Treatment Outcome
chemical_list: D000068338:Everolimus; D017239:Paclitaxel
keywords: Dialysis; Everolimus-eluting stent; Paclitaxel-eluting stent; Percutaneous coronary intervention