title: Tregs activated by bispecific antibodies: Killers or suppressors?
abstract: In recent years, bispecific antibodies (bsAb) have emerged as promising tools for a target-specific redirection of T cells in order to eliminate malignant cells. However, CD3-engaging constructs might also activate T regulatory cells (Tregs) present in the tumor microenvironment. Whether this has detrimental or beneficial effects for tumor therapy is still controversially discussed.
authors.affiliation: Tumorimmunology; University Cancer Center (UCC); Medical Faculty Carl Gustav Carus; Technical University Dresden ; Dresden, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Koristka
authors.affiliation: Tumorimmunology; University Cancer Center (UCC); Medical Faculty Carl Gustav Carus; Technical University Dresden ; Dresden, Germany ; Cellex Patient Treatment GmbH ; Dresden, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Cartellieri
authors.affiliation: Tumorimmunology; University Cancer Center (UCC); Medical Faculty Carl Gustav Carus; Technical University Dresden ; Dresden, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Arndt
authors.affiliation: Helmholtz-Zentrum Dresden-Rossendorf (HZDR); Institute of Radiopharmaceutical Cancer Research ; Dresden, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Feldmann
authors.affiliation: Institute of Medical Immunology; Martin-Luther-University-Halle-Wittenberg ; Halle, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Seliger
authors.affiliation: Medical Clinic and Policlinic I; University Hospital 'Carl Gustav Carus' ; Dresden, Germany.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ehninger
authors.affiliation: Tumorimmunology; University Cancer Center (UCC); Medical Faculty Carl Gustav Carus; Technical University Dresden ; Dresden, Germany ; Helmholtz-Zentrum Dresden-Rossendorf (HZDR); Institute of Radiopharmaceutical Cancer Research ; Dresden, Germany ; DFG-Center for Regenerative Therapies Dresden; Cluster of Excellence; Technical University Dresden ; Dresden, Germany.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Bachmann
keywords: T cell retargeting; T regulatory cells; cytotoxicity; immunosuppression, immunotherapy; single-chain bispecific antibodies