title: Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making.
abstract: BACKGROUND
  Safety assessment for repeated dose toxicity is one of the largest challenges in the process to replace animal testing. This is also one of the proof of concept ambitions of SEURAT-1, the largest ever European Union research initiative on alternative testing, co-funded by the European Commission and Cosmetics Europe. This review is based on the discussion and outcome of a workshop organized on initiative of the SEURAT-1 consortium joined by a group of international experts with complementary knowledge to further develop traditional read-across and include new approach data.
  
  
  OBJECTIVE
  The aim of the suggested strategy for chemical read-across is to show how a traditional read-across based on structural similarities between source and target substance can be strengthened with additional evidence from new approach data--for example, information from in vitro molecular screening, "-omics" assays and computational models--to reach regulatory acceptance.
  
  
  METHODS
  We identified four read-across scenarios that cover typical human health assessment situations. For each such decision context, we suggested several chemical groups as examples to prove when read-across between group members is possible, considering both chemical and biological similarities.
  
  
  CONCLUSIONS
  We agreed to carry out the complete read-across exercise for at least one chemical category per read-across scenario in the context of SEURAT-1, and the results of this exercise will be completed and presented by the end of the research initiative in December 2015.
authors.affiliation: Joint Research Centre, European Commission, Ispra, Italy.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Berggren
authors.forename: Patric
authors.initials: P
authors.lastname: Amcoff
authors.forename: Romualdo
authors.initials: R
authors.lastname: Benigni
authors.forename: Karen
authors.initials: K
authors.lastname: Blackburn
authors.forename: Edward
authors.initials: E
authors.lastname: Carney
authors.forename: Mark
authors.initials: M
authors.lastname: Cronin
authors.forename: Hubert
authors.initials: H
authors.lastname: Deluyker
authors.forename: Francoise
authors.initials: F
authors.lastname: Gautier
authors.forename: Richard S
authors.initials: RS
authors.lastname: Judson
authors.forename: Georges E N
authors.initials: GE
authors.lastname: Kass
authors.forename: Detlef
authors.initials: D
authors.lastname: Keller
authors.forename: Derek
authors.initials: D
authors.lastname: Knight
authors.forename: Werner
authors.initials: W
authors.lastname: Lilienblum
authors.forename: Catherine
authors.initials: C
authors.lastname: Mahony
authors.forename: Ivan
authors.initials: I
authors.lastname: Rusyn
authors.forename: Terry
authors.initials: T
authors.lastname: Schultz
authors.forename: Michael
authors.initials: M
authors.lastname: Schwarz
authors.forename: Gerrit
authors.initials: G
authors.lastname: Schüürmann
authors.forename: Andrew
authors.initials: A
authors.lastname: White
authors.forename: Julien
authors.initials: J
authors.lastname: Burton
authors.forename: Alfonso M
authors.initials: AM
authors.lastname: Lostia
authors.forename: Sharon
authors.initials: S
authors.lastname: Munn
authors.forename: Andrew
authors.initials: A
authors.lastname: Worth
mesh_terms: D000826:Animal Testing Alternatives; D062067:Chemical Safety; D003198:Computer Simulation; D003657:Decision Making; D005062:European Union; D006801:Humans; D021281:Quantitative Structure-Activity Relationship; D018675:Toxicity Tests / Q000379:methods* / Q000592:standards