title: Engineered biosynthesis of natural products in heterologous hosts.
abstract: Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.
authors.affiliation: Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300072, P. R. China. yjyuan@tju.edu.cn.
authors.forename: Yunzi
authors.initials: Y
authors.lastname: Luo
authors.forename: Bing-Zhi
authors.initials: BZ
authors.lastname: Li
authors.forename: Duo
authors.initials: D
authors.lastname: Liu
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Jia
authors.forename: Bo-Xuan
authors.initials: BX
authors.lastname: Zeng
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhao
authors.forename: Ying-Jin
authors.initials: YJ
authors.lastname: Yuan
mesh_terms: D000470:Alkaloids / Q000378:metabolism; D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001688:Biological Products / Q000378:metabolism*; D001709:Biotechnology; D005419:Flavonoids / Q000378:metabolism; D060847:Metabolic Engineering; D013729:Terpenes / Q000378:metabolism
chemical_list: D000470:Alkaloids; D001688:Biological Products; D005419:Flavonoids; D013729:Terpenes