title: An insertion/deletion polymorphism at miRNA-122 binding site in the IL1A is associated with a reduced risk of cervical squamous cell carcinoma.
abstract: OBJECTIVE
  Previous studies have shown that miRNA plays a key role in cervical carcinogenesis. Interleukin (IL)-1α can promote tumor growth, invasion, migration, and angiogenesis. An insertion/deletion polymorphism (rs3783553) in the IL1A 3' untranslated region may disrupt a binding site for miR-122 and miR-378 and thus change the transcription of IL-1α. The purpose of this study was to evaluate the association between the rs3783553 polymorphism and the risk of cervical squamous cell carcinoma (CSCC).
  
  
  METHODS
  Polymerase chain reaction was used to genotype the IL1A rs3783553 polymorphism in 235 patients with CSCC and 326 controls.
  
  
  RESULTS
  We found that the ins/ins genotype had a decreased risk to develop CSCC (odds ratio [OR]=0.48, 95% confidence interval [CI], 0.25-0.95). However, no significant association was observed between the IL1A rs3783553 genotype and clinical features.
  
  
  CONCLUSIONS
  These findings indicate that the IL1A rs3783553 polymorphism may be associated with the etiology of CSCC.
authors.affiliation: 1 Department of Obstetrics and Gynecology, Chengdu Women's and Children's Central Hospital , Chengdu, People's Republic of China .
authors.forename: Juan
authors.initials: J
authors.lastname: Huang
authors.affiliation: 2 Department of Obstetrics and Gynecology, Tianjin Central Hospital of Gynecology Obstetrics , Tianjin, People's Republic of China .
authors.forename: Shanshan
authors.initials: S
authors.lastname: Ni
authors.affiliation: 3 Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University , Chengdu, People's Republic of China .
authors.forename: Danqing
authors.initials: D
authors.lastname: Li
authors.affiliation: 3 Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University , Chengdu, People's Republic of China .
authors.forename: Yuedong
authors.initials: Y
authors.lastname: He
mesh_terms: D000328:Adult; D001665:Binding Sites; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation; D053582:Interleukin-1alpha / Q000097:blood / Q000235:genetics*; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000235:genetics*
chemical_list: C508584:IL1A protein, human; D053582:Interleukin-1alpha; C531907:MIRN122 microRNA, human; D035683:MicroRNAs