title: A study on EEG-based brain electrical source of mild depressed subjects.
abstract: OBJECTIVE
  Several abnormal brain regions are known to be linked to depression, including amygdala, orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex (DLPFC) etc. The aim of this study is to apply EEG (electroencephalogram) data analysis to investigate, with respect to mild depression, whether there exists dysregulation in these brain regions.
  
  
  METHODS
  EEG sources were assessed from 9 healthy and 9 mildly depressed subjects who were classified according to the Beck Depression Inventory (BDI) criteria. t-Test was used to calculate the eye movement data and standardized low resolution tomography (sLORETA) was used to correlate EEG activity.
  
  
  RESULTS
  A comparison of eye movement data between the healthy and mild depressed subjects exhibited that mildly depressed subjects spent more time viewing negative emotional faces. Comparison of the EEG from the two groups indicated higher theta activity in BA6 (Brodmann area) and higher alpha activity in BA38.
  
  
  CONCLUSIONS
  EEG source location results suggested that temporal pole activity to be dysregulated, and eye-movement data analysis exhibited mild depressed subjects paid much more attention to negative face expressions, which is also in accordance with the results of EEG source location.
authors.affiliation: School of Information Science and Engineering, Lanzhou University, Lanzhou, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Information Science and Engineering, Lanzhou University, Lanzhou, China. Electronic address: bh@lzu.edu.cn.
authors.forename: Bin
authors.initials: B
authors.lastname: Hu
authors.affiliation: School of Information Science and Engineering, Lanzhou University, Lanzhou, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Xu
authors.affiliation: School of Information Science and Engineering, Lanzhou University, Lanzhou, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Shen
authors.affiliation: School of Computing, Telecommunications and Networks, Birmingham City University, Birmingham, United Kingdom.
authors.forename: Martyn
authors.initials: M
authors.lastname: Ratcliffe
mesh_terms: D001921:Brain / Q000503:physiopathology; D003863:Depression / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods*; D005133:Eye Movements; D006801:Humans
keywords: EEG; Eye movement; Mild depression; sLORETA