title: An Improved and Efficient Process for the Preparation of (+)-cloprostenol.
abstract: An improved and efficient synthesis of (+)-cloprostenol has been accomplished in nine steps and 26% overall yield from commercially available (-)-Corey lactone 4-phenylbenzoate alcohol . The present route avoids tedious purifications and requires only one column chromatography operation, which reduces the generation of waste and is suitable for large-scale preparation.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
authors.forename: Hui-Xuan
authors.initials: HX
authors.lastname: Chen
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Weng
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.|Institute of Human Virology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Gui
authors.initials: G
authors.lastname: Lu
mesh_terms: D002853:Chromatography, Liquid; D003008:Cloprostenol / Q000138:chemical synthesis*; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D003008:Cloprostenol
keywords: (+)-cloprostenol; Corey lactone; asymmetric reduction; process development; prostaglandin; synthesis