title: Novel markers in the diagnostics of endometriomas: Urocortin, ghrelin, and leptin or leukocytes, fibrinogen, and CA-125?
abstract: OBJECTIVE
  CA-125 protein is used as a marker in clinical practice for the diagnosis of endometriomas. The aim of this study was to determine whether endometriomas are accompanied by an increased level of urocortin, ghrelin, and leptin, as well as the increased parameters of blood cell count, fibrinogen, and CA-125.
  
  
  METHODS
  The study included 86 women aged 18-38 years who had been treated laparoscopically for lesions in the adnexa with the characteristics of endometriomas and mature teratoma, during the period September 2009 to November 2012. The statistical analysis was performed using the nonparametric Mann-Whitney U test and the Spearman rank correlation coefficients (p ≤ 0.05).
  
  
  RESULTS
  The medians were 105.31 pg/mL versus 120.84 pg/mL for urocortin, 7.16 pg/mL versus 9.13 pg/mL for leptin and 584.33 pg/mL versus 657.82 pg/mL for ghrelin (p > 0.05), respectively. Analyzing the parameters of blood cell count, statistically significant differences were shown in the respective groups for leucocyte level (5.35 × 10(9)/L vs. 6.7 × 10(9)/L; p = 0.029), fibrinogen level (3.12 mg% vs. 2.57 mg%; p = 0.001), and CA-125 (36.50 U/mL vs. 15.08 U/mL; p = 0.001).
  
  
  CONCLUSIONS
  In conclusion, the prognostic values for CA-125, leukocytes, and fibrinogen may prove a very useful tool for the diagnosis of lesions in the adnexa of the type endometriomas.
authors.affiliation: Department of Maternal and Child Health, University of Medical Sciences, Poznań, Poland. Electronic address: karolinachmaj@poczta.onet.pl.
authors.forename: Karolina
authors.initials: K
authors.lastname: Chmaj-Wierzchowska
authors.affiliation: Clinic of Surgical Gynecology, University of Medical Sciences, Poznań, Poland; Department of Medical Education, University of Medical Sciences, Poznań, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Kampioni
authors.affiliation: Department of Medical Education, University of Medical Sciences, Poznań, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Wilczak
authors.affiliation: Clinic of Surgical Gynecology, University of Medical Sciences, Poznań, Poland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Sajdak
authors.affiliation: Department of Maternal and Child Health, University of Medical Sciences, Poznań, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Opala
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D004715:Endometriosis / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D007958:Leukocyte Count; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D013724:Teratoma / Q000097:blood / Q000175:diagnosis; D054832:Urocortins / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen; D054439:Ghrelin; D020738:Leptin; D054832:Urocortins; D005340:Fibrinogen
keywords: CA-125; endometriomas; ghrelin; leptin; leukocytes