title: Variation in functional connectivity along anterior-to-posterior intraparietal sulcus, and relationship with age across late childhood and adolescence.
abstract: The intraparietal sulcus (IPS), a region in the dorsal attention network (DAN), has been implicated in multi-sensory attention and working memory. Working memory and attention develop across childhood; changes in functional connectivity within the DAN may relate to this maturation. Previous findings regarding fronto-parietal intrinsic functional connectivity age-effects were mixed. Our study aimed to circumvent limitations of previous work using a large cross-sectional sample, 183 typically developing participants 6.5-20 years, from the Autism Brain Imaging Data Exchange, and seed regions along the anterior-to-posterior axis of the IPS. These seeds, IPS0-4, were entered into functional connectivity models. Group-level models investigated differential connectivity along the IPS and relationships with age. Anterior IPS3/4 exhibited greater connectivity with sensorimotor/pre-motor regions. Posterior IPS0/1 demonstrated greater connectivity with dorsal and ventral visual regions. Positive age-effects were found between IPS3-4 and visual regions. Negative age-effects were found between IPS and superior parietal and medial orbitofrontal cortices. Follow-up region of interest analyses were used to estimate age-effects for DAN and anticorrelated default mode network regions. Results suggest age-effects on IPS functional connectivity are relatively modest, and may differ pre- and across-adolescence. Studying typical age-related connectivity variability within this network may help to understand neurodevelopmental disorders marked by impaired attention.
authors.affiliation: Alberta Children's Hospital Research Institute, Room 293, Heritage Medical Research Building, 3330 Hospital Drive, NW, Calgary, AB, Canada T2N 4N1; Department of Radiology, Cumming School of Medicine, University of Calgary, Room 812, North Tower, Foothills Medical Centre, 1403 - 29th Street NW, Calgary, AB, Canada T2N 2T9; Child and Adolescent Imaging Research Program, Alberta Children's Hospital, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8. Electronic address: savinett@ucalgary.ca.
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Vinette
authors.affiliation: Alberta Children's Hospital Research Institute, Room 293, Heritage Medical Research Building, 3330 Hospital Drive, NW, Calgary, AB, Canada T2N 4N1; Department of Radiology, Cumming School of Medicine, University of Calgary, Room 812, North Tower, Foothills Medical Centre, 1403 - 29th Street NW, Calgary, AB, Canada T2N 2T9; Department of Paediatrics, Cumming School of Medicine, University of Calgary, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8; Child and Adolescent Imaging Research Program, Alberta Children's Hospital, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8. Electronic address: slbray@ucalgary.ca.
authors.forename: Signe
authors.initials: S
authors.lastname: Bray
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000375:Aging / Q000502:physiology; D001288:Attention; D003430:Cross-Sectional Studies; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D009415:Nerve Net / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D055815:Young Adult
keywords: Attention; Functional connectivity; IPS; Resting-state fMRI; Visual-spatial; Visuotopic