title: Iminolactones from Schizophyllum commune.
abstract: Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of cancer cells.
authors.affiliation: †Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.|‡Chemistry Department, Guangxi Medical University, Shuang Yong Road, Nan Ning, Guang Xi, People's Republic of China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Liu
authors.affiliation: †Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Karla
authors.initials: K
authors.lastname: Frydenvang
authors.affiliation: †Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Huizhen
authors.initials: H
authors.lastname: Liu
authors.affiliation: §Department of Clinical Microbiology 7602, Rigshospitalet, Tagensvej 20, DK-2200 Copenhagen N, Denmark.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhai
authors.affiliation: §Department of Clinical Microbiology 7602, Rigshospitalet, Tagensvej 20, DK-2200 Copenhagen N, Denmark.
authors.forename: Ming
authors.initials: M
authors.lastname: Chen
authors.affiliation: ⊥Department of Basic Sciences and Environment, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.
authors.forename: Carl Erik
authors.initials: CE
authors.lastname: Olsen
authors.affiliation: †Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
authors.forename: Søren Brøgger
authors.initials: SB
authors.lastname: Christensen
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003718:Denmark; D004354:Drug Screening Assays, Antitumor; D005260:Female; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010649:Phenylalanine / Q000378:metabolism; D012567:Schizophyllum / Q000737:chemistry*; D014364:Tryptophan / Q000378:metabolism
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D007783:Lactones; D010078:Oxazines; C000599865:schizine A; C000599866:schizine B; D010649:Phenylalanine; D014364:Tryptophan