title: Salivary gland development and disease.
abstract: Mammalian salivary glands synthesize and secrete saliva via a vast interconnected network of epithelial tubes attached to secretory end units. The extensive morphogenesis required to establish this organ is dependent on interactions between multiple cell types (epithelial, mesenchymal, endothelial, and neuronal) and the engagement of a wide range of signaling pathways. Here we describe critical regulators of salivary gland development and discuss how mutations in these impact human organogenesis. In particular, we explore the genetic contribution of growth factor pathways, nerve-derived factors and extracellular matrix molecules to salivary gland formation in mice and humans.
authors.affiliation: Department of Cell & Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Aaron
authors.initials: A
authors.lastname: Mattingly
authors.affiliation: Department of Cell & Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Finley
authors.affiliation: Department of Cell & Tissue Biology, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Knox
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D009024:Morphogenesis / Q000502:physiology*; D038081:Organogenesis / Q000502:physiology*; D012469:Salivary Glands / Q000254:growth & development*; D015398:Signal Transduction / Q000502:physiology