title: Adult stem-like cells exclude "older" mitochondria.
abstract: Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containing younger mitochondria maintaining the SLC pool.
authors.affiliation: Departments of Pathology and Laboratory Medicine, Pediatrics, and Bioengineering, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Broad Stem Cell Research Center, and California NanoSystems Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: mteitell@ucla.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Teitell
mesh_terms: D002455:Cell Division / Q000502:physiology*; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology* / Q000648:ultrastructure*