title: Responsiveness of selected outcome measures of participation restriction and quality of life in patients with multiple sclerosis.
abstract: OBJECTIVE
  To evaluate the responsiveness of two outcome measures of participation restriction [as measured by the Community Integration Questionnaire (CIQ)] and quality of life [as measured by the Multiple Sclerosis Quality of Life (MSQOL)] following a physiotherapy intervention in patients with multiple sclerosis (MS).
  
  
  METHODS
  A sample of 265 patients completed both instruments first at the time of initial visit and then after 4-6 weeks physiotherapy. In addition, patients were asked to complete the 7-point global rating scale as an external criterion of change at the post-intervention time. The responsiveness was evaluated using the receiver operating characteristics (ROC) method and the correlation analysis. Two useful statistics were area under the ROC curve (AUC) and the minimally clinically important difference (MCID). The AUC and correlation coefficient greater than 0.70 were considered as acceptable responsiveness.
  
  
  RESULTS
  The CIQ achieved the acceptable responsiveness with an AUC of 0.81. However, the AUCs of 0.61 and 0.66 were obtained for the MSQOL physical and mental, respectively. Moreover, good correlation coefficient was obtained for the CIQ (Gamma = 0.76) while fair correlations of 0.28 and 0.33 were obtained for the MSQOL physical and mental, respectively. The MCIDs were approximately 0.50, 1.5 and 2.5 points for the CIQ, MSQOL physical and mental, respectively.
  
  
  CONCLUSIONS
  In contrast to the MSQOL, the CIQ was responsive outcome measure in detecting changes in participation restriction of patients with MS. Moreover, the MCID values obtained in this study will help the clinicians and researchers to determine if a patient with MS has experienced a true change following physiotherapy intervention.
  
  
  CONCLUSIONS
  The results provide valuable information regarding to the ability of two outcome measures (i.e. the CIQ and MSQOL) to detect treatment effects in patients with MS. In contrast to the MSQOL, the CIQ is a responsive measure to changes in participation restriction due to physiotherapy. A patient with MS had to change at least 0.50 point on the CIQ, 1.5 points on the MSQOL physical and 2.5 points on the MSQOL mental to be judged as having clinically changed.
authors.affiliation: a Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran .
authors.forename: Mahdie
authors.initials: M
authors.lastname: Taheri
authors.affiliation: b Department of Physical Therapy, School of Paramedical Sciences , Mashhad University of Medical Sciences , Mashhad , Iran , and.
authors.forename: Hossein
authors.initials: H
authors.lastname: Negahban
authors.affiliation: a Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran .
authors.forename: Neda
authors.initials: N
authors.lastname: Mostafaee
authors.affiliation: a Musculoskeletal Rehabilitation Research Center, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran .
authors.forename: Reza
authors.initials: R
authors.lastname: Salehi
authors.affiliation: c Department of Biostatistics and Epidemiology, School of Health , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Tabesh
mesh_terms: D000328:Adult; D019540:Area Under Curve; D062309:Community Integration; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007492:Iran; D008297:Male; D009103:Multiple Sclerosis / Q000534:rehabilitation*; D010358:Patient Participation; D026741:Physical Therapy Modalities / Q000592:standards*; D011788:Quality of Life / Q000523:psychology*; D012372:ROC Curve; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
keywords: Community integration; multiple sclerosis; participation; quality of life; responsiveness