title: Pushing and pulling on adult neural stem cells.
abstract: How plastic is adult neurogenesis? In this issue of Cell Stem Cell, Sierra et al. (2015) use epilepsy models to probe how hippocampal neural stem cells (NSCs) respond to graded pathological conditions. They uncover changes in cell fate potential upon NSC activation, but it comes at a cost.
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, W.M. Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Albina
authors.initials: A
authors.lastname: Ibrayeva
authors.affiliation: Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, W.M. Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: mbonagui@usc.edu.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Bonaguidi
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D004827:Epilepsy / Q000503:physiopathology*; D006624:Hippocampus / Q000166:cytology*; D006801:Humans; D058953:Neural Stem Cells / Q000502:physiology*; D011595:Psychomotor Agitation / Q000503:physiopathology*