title: α-1-Acid glycoprotein as a biomarker for the early diagnosis and monitoring the prognosis of sepsis.
abstract: OBJECTIVE
  To explore the value of α-1-acid glycoprotein (AGP) for the early diagnostic and prognostic assessment of patients with sepsis.
  
  
  METHODS
  Eighty-five patients with systemic inflammatory response syndrome (SIRS) and 192 patients with sepsis were enrolled. White blood cell counts and serum levels of AGP, C-reactive protein, and procalcitonin were tested on the day of admission to intensive care unit (ICU; day 1) and the following days 3, 5, 7, and 10.
  
  
  RESULTS
  The sepsis group exhibited significantly higher levels of AGP than did the SIRS group on day 1 (P < .05); the area under the curve (AUC) of AGP was 0.869 with a specificity of 0.902 on diagnosis of sepsis. The differences were statistically significant among sepsis subgroups. On prognostic assessment, the areas under the curve of AGP, Sequential Organ Failure Assessment (SOFA) scores, and SOFA + AGP on ICU admission were 0.793, 0.813, and 0.878, respectively. The results of logistic regression showed that the odds ratios of AGP, SOFA, Acute Physiology and Chronic Health Evaluation II, and the length of ICU stay were 1.450, 1.212, 1.673, and 1.130.
  
  
  CONCLUSIONS
  α-1-Acid glycoprotein could distinguish sepsis from SIRS and also be used to effectively assess the severity of sepsis. In addition, combined AGP and SOFA scores had a great predicting value in prognosis of sepsis.
authors.affiliation: Department of Respiratory Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Xiao
authors.affiliation: Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Longxiang
authors.initials: L
authors.lastname: Su
authors.affiliation: Department of Respiratory Medicine, Hainan Branch of Chinese PLA General Hospital, Hainan, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yan
authors.affiliation: Department of Respiratory Medicine, Bethune International Peace Hospital, Shijiazhuang, China.
authors.forename: Bingchao
authors.initials: B
authors.lastname: Han
authors.affiliation: Nanlou Respiratory Diseases Department, Chinese PLA General Hospital, Beijing, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Department of Internal Medicine, Chinese PLA General Hospital, Beijing, China. Electronic address: lixin301@sina.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China. Electronic address: xielx@263.net.
authors.forename: Lixin
authors.initials: L
authors.lastname: Xie
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood*; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide; D002681:China; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007902:Length of Stay; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D063305:Organ Dysfunction Scores; D009961:Orosomucoid / Q000378:metabolism*; D011379:Prognosis; D011446:Prospective Studies; D011498:Protein Precursors; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000175:diagnosis* / Q000401:mortality
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D009961:Orosomucoid; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide
keywords: Biomarker; Diagnosis; Prognosis; Sepsis; Severity; α-1-Acid glycoprotein (AGP)