title: Tumor Bed Boost Integration during Whole Breast Radiotherapy: A Review of the Current Evidence.
abstract: Radiation therapy delivered with hypofractionation, which involves the delivery of a higher dose per fraction in fewer fractions (generally with a lower total nominal dose) over a shorter overall treatment time, is an established therapeutic option at least for a selected group of early breast cancer patients after breast-conserving surgery. Optimal delivery of the tumor bed boost dose in terms of timing, fractionation, and total dose whenever a hypofractionated schedule is employed has yet to be established. We herein present a review of the current evidence on the role of boost integration in whole breast radiotherapy.
authors.affiliation: Department of Oncology, Radiation Oncology, University of Torino, Turin, Italy.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Franco
authors.affiliation: Radiation Oncology Department, Ivrea Community Hospital, ASLTO4, Ivrea, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Cante
authors.affiliation: Radiation Oncology Department, Ivrea Community Hospital, ASLTO4, Ivrea, Italy.
authors.forename: Piera
authors.initials: P
authors.lastname: Sciacero
authors.affiliation: Radiation Oncology Department, Ivrea Community Hospital, ASLTO4, Ivrea, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Girelli
authors.affiliation: Radiation Oncology Department, Ivrea Community Hospital, ASLTO4, Ivrea, Italy.
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: La Porta
authors.affiliation: Department of Oncology, Radiation Oncology, University of Torino, Turin, Italy.
authors.forename: Umberto
authors.initials: U
authors.lastname: Ricardi
keywords: Adjuvant whole breast radiotherapy; Breast cancer; Concomitant boost; Hypofractionation; IGRT; IMRT; Simultaneous integrated boost