title: A mathematical model to elucidate brain tumor abrogation by immunotherapy with T11 target structure.
abstract: T11 Target structure (T11TS), a membrane glycoprotein isolated from sheep erythrocytes, reverses the immune suppressed state of brain tumor induced animals by boosting the functional status of the immune cells. This study aims at aiding in the design of more efficacious brain tumor therapies with T11 target structure. We propose a mathematical model for brain tumor (glioma) and the immune system interactions, which aims in designing efficacious brain tumor therapy. The model encompasses considerations of the interactive dynamics of glioma cells, macrophages, cytotoxic T-lymphocytes (CD8(+) T-cells), TGF-β, IFN-γ and the T11TS. The system undergoes sensitivity analysis, that determines which state variables are sensitive to the given parameters and the parameters are estimated from the published data. Computer simulations were used for model verification and validation, which highlight the importance of T11 target structure in brain tumor therapy.
authors.affiliation: Department of Mathematics, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttaranchal, India.
authors.forename: Sandip
authors.initials: S
authors.lastname: Banerjee
authors.affiliation: Department of Mathematics, Indian Institute of Technology Roorkee, Roorkee - 247667, Uttaranchal, India.
authors.forename: Subhas
authors.initials: S
authors.lastname: Khajanchi
authors.affiliation: Department of Laboratory Medicine, School of Tropical Medicine, Kolkata-700073, West Bengal, India.
authors.forename: Swapna
authors.initials: S
authors.lastname: Chaudhuri
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D005910:Glioma / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D007371:Interferon-gamma / Q000494:pharmacology; D016018:Least-Squares Analysis; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008562:Membrane Glycoproteins / Q000008:administration & dosage / Q000276:immunology*; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D051381:Rats; D012756:Sheep; D016212:Transforming Growth Factor beta / Q000494:pharmacology
chemical_list: D008562:Membrane Glycoproteins; D016212:Transforming Growth Factor beta; D007371:Interferon-gamma