title: Anaplastic lymphoma kinase (ALK) positive anaplastic large cell lymphoma (ALCL) of breast in a patient without a breast implant.
abstract: Non-Hodgkin lymphoma of the breast is an uncommon entity accounting for approximately 0.5% of malignant breast neoplasms and around 3% of extranodal lymphomas. Most cases of anaplastic large cell lymphoma (ALCL) of the breast have been associated with breast implants, and a few ALCL aris.ing de novo in patients without breast implants have been reported. We report a case of a 19-year-old female who presented with a lump in the right breast of 3 months' duration. Examination revealed an Eastern Cooperative Oncology Group performance status of 2 and a 6.5 cm2 lump in the right breast. Lumpectomy revealed large neoplastic cells positive for CD30, EMA, CD5, and anaplastic lymphoma kinase (ALK), suggestive of anaplastic large cell lymphoma. The patient underwent lumpectomy followed by 6 cycles of anthracycline-based chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone 3 weekly. On follow up, this patient had an event-free survival of 23 months. We are reporting this case of ALCL (ALK positive) in a patient with no breast implant previously, and hence, it is of clinical importance.
authors.forename: Vishwanath
authors.initials: V
authors.lastname: Sathyanarayanan
authors.affiliation: Dr Lokesh KN, Asst. Professor Department of Medical Oncology,, Kidwai Memorial Institute of Oncology, Bangalore,, Karnataka, Bangalore 560029, India, knloki@gmail.com.
authors.forename: Kadabur Nagendrappa
authors.initials: KN
authors.lastname: Lokesh
authors.forename: K C
authors.initials: KC
authors.lastname: Lakshmaiah
authors.affiliation: Dr Lokesh KN, Asst. Professor Department of Medical Oncology,, Kidwai Memorial Institute of Oncology, Bangalore,, Karnataka, Bangalore 560029, India, knloki@gmail.com.
authors.forename: K
authors.initials: K
authors.lastname: Govind Babu
authors.affiliation: Dr Lokesh KN, Asst. Professor Department of Medical Oncology,, Kidwai Memorial Institute of Oncology, Bangalore,, Karnataka, Bangalore 560029, India, knloki@gmail.com.
authors.forename: D
authors.initials: D
authors.lastname: Lokanatha
authors.forename: M C
authors.initials: MC
authors.lastname: Suresh Babu
authors.forename: Clementina Rama
authors.initials: CR
authors.lastname: Rao
authors.forename: Premalata
authors.initials: P
authors.lastname: Chennagiri
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D018427:Breast Implants; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000378:metabolism* / Q000473:pathology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D055815:Young Adult
chemical_list: C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases