title: CYFRA21-1 levels could be a biomarker for bladder cancer: a meta-analysis.
abstract: The proteolytic region of cytokeratin-19, referred to as CYFRA21-1, is a soluble molecule present in the serum and other body fluids, and is considered a tumor marker in several neoplastic diseases. To examine whether urinary or serum samples containing CYFRA21-1 can be used as biomarkers for bladder cancer, we conducted a comprehensive meta-analysis of 3 case-control studies. In all studies considered, patients with bladder cancer had a higher CYFRA21-1 level than healthy subjects. Subgroup analysis showed that patients with metastatic bladder cancer had a higher CYFRA21-1 level than those with locally invasive disease. However, no significant difference in CYFRA21-1 was observed between patients with stage I and stage II bladder cancer; there was also no difference in patients with stage II local bladder cancer and those with stage III local bladder cancer. Based on our results, CYFRA21-1 level may be a diagnostic biomarker for diagnosing bladder cancer as well as a possible biomarker for differentiation between local and metastatic bladder cancer. However, it cannot be used as a urinary or serum biomarker for differentiating histological stages of local bladder cancer for histological grades I-III.
authors.affiliation: Department of Pathology, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang, Liaoning, China.
authors.forename: L I
authors.initials: LI
authors.lastname: Kuang
authors.affiliation: Department of Urological Surgery, Red Cross Hospital of Shenyang, Liaoning, China.
authors.forename: W J
authors.initials: WJ
authors.lastname: Song
authors.affiliation: Department of Pathology, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang, Liaoning, China.
authors.forename: H M
authors.initials: HM
authors.lastname: Qing
authors.affiliation: Department of Urological Surgery, Red Cross Hospital of Shenyang, Liaoning, China.
authors.forename: S
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Pathology, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang, Liaoning, China mac_kl@126.com.
authors.forename: F L
authors.initials: FL
authors.lastname: Song
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood / Q000378:metabolism* / Q000652:urine; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism* / Q000652:urine; D016022:Case-Control Studies; D006801:Humans; D053539:Keratin-19 / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D053539:Keratin-19; C102012:antigen CYFRA21.1