title: [Therapeutic potential of optogenetic neuromodulation].
abstract: Optogenetic neuromodulation techniques, which have emerged during the last 15 years, have considerably enhanced our ability to probe the functioning of neural circuits by allowing the excitation and inhibition of genetically-defined neuronal populations using light. Having gained tremendous popularity in the field of fundamental neuroscience, these techniques are now opening new therapeutic avenues. Optogenetic neuromodulation is a method of choice for studying the physiopathology of neurological and neuropsychiatric disorders in a range of animal models, and could accelerate the discovery of new therapeutic strategies. New therapeutic protocols employing optogenetic neuromodulation may also emerge in the near future, offering promising alternative approaches for disorders which lack appropriate treatments, such as pharmacoresistant epilepsy and inherited retinal degeneration.
authors.affiliation: Équipe dynamique et pathophysiologie des réseaux neuronaux, centre interdisciplinaire de recherche en biologie, CNRS UMR 7241, Inserm U1050, Collège de France, 11, place Marcelin Berthelot, 75005 Paris, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Vandecasteele
authors.affiliation: AP-HP, hôpital Henri Mondor, service de neurochirurgie, 94000 Créteil, France - Inserm, U955, équipe 14, 94000 Créteil, France - Université Paris Est, faculté de médecine, 94000 Créteil, France.
authors.forename: Yann-Suhan
authors.initials: YS
authors.lastname: Senova
authors.affiliation: AP-HP, hôpital Henri Mondor, service de neurochirurgie, 94000 Créteil, France - Inserm, U955, équipe 14, 94000 Créteil, France - Université Paris Est, faculté de médecine, 94000 Créteil, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Palfi
authors.affiliation: CNRS UMR 8197, Inserm U1024, institut de biologie de l'école normale supérieure, 46, rue d'Ulm, 75005 Paris, France.
authors.forename: Guillaume P
authors.initials: GP
authors.lastname: Dugué
mesh_terms: D000818:Animals; D004827:Epilepsy / Q000628:therapy; D005822:Genetic Vectors; D006801:Humans; D008027:Light; D001523:Mental Disorders / Q000628:therapy*; D051379:Mice; D008822:Mice, Transgenic; D009417:Nerve Tissue / Q000378:metabolism / Q000528:radiation effects; D018377:Neurotransmitter Agents / Q000235:genetics / Q000627:therapeutic use*; D062308:Optogenetics / Q000379:methods*; D010300:Parkinson Disease / Q000628:therapy; D014780:Viruses / Q000235:genetics
chemical_list: D018377:Neurotransmitter Agents