title: HIF-2α/ITPR1 axis: A new saboteur of NK-mediated lysis.
abstract: We recently investigated the role of von Hippel-Lindau (VHL)mutation and the subsequent induction of hypoxia-inducible factor 2α (HIF-2α) in the regulation of renal cell carcinoma (RCC) susceptibility to natural killer (NK) cell-mediated killing. We demonstrated that the resistance ofVHL-mutated RCC cell line 786-0 to NK-mediated lysis requires HIF-2α and ITPR1, a direct novel target of HIF-2α, through the activation of autophagy in target cells by NK-derived signals.
authors.affiliation: INSERM U753; Gustave Roussy Cancer campus ; Villejuif, France.
authors.forename: Yosra
authors.initials: Y
authors.lastname: Messai
authors.affiliation: INSERM U753; Gustave Roussy Cancer campus ; Villejuif, France.
authors.forename: Muhammad Zaeem
authors.initials: MZ
authors.lastname: Noman
authors.affiliation: INSERM U753; Gustave Roussy Cancer campus ; Villejuif, France.
authors.forename: Meriem
authors.initials: M
authors.lastname: Hasmim
authors.affiliation: Medical Oncology Department; Gustave Roussy Cancer Campus ; Villejuif, France.
authors.forename: Bernard
authors.initials: B
authors.lastname: Escudier
authors.affiliation: INSERM U753; Gustave Roussy Cancer campus ; Villejuif, France.
authors.forename: Salem
authors.initials: S
authors.lastname: Chouaib
keywords: HIF-2α; ITPR1; NK cell; autophagy; clear cell renal cell carcinoma; pVHL