title: Platelet activation is a key event in the pathogenesis of streptococcal infections.
abstract: Diverse Streptococcus species including Streptococcus Pneumoniae, Sanguis, Gordonii, Mitis and Mutans cause life-threatening conditions including pneumonia, bacteremia and meningitis. These diseases bear a high morbidity and mortality and for this reason, understanding the key events in the pathogenesis of these infections have a great significance in their prevention and/or treatment. Here, we describe as how the activation of the platelets and their affinity to bind to bacterial proteins act as early key events in the pathogenesis of Streptococcal infections.
authors.forename: Ming
authors.initials: M
authors.lastname: Jia
authors.forename: Yuling
authors.initials: Y
authors.lastname: Xiong
authors.forename: Hua
authors.initials: H
authors.lastname: Lu
authors.forename: Ruqing
authors.initials: R
authors.lastname: Li
authors.forename: Tiantian
authors.initials: T
authors.lastname: Wang
authors.forename: Yanyao
authors.initials: Y
authors.lastname: Ye
authors.forename: Min
authors.initials: M
authors.lastname: Song
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Tianlun
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Department of Blood Transfusion, Southwest Hospital, The Third Military Medical University, No. 30 Street Gaotanyan, Chongqing 400038, China, shumingzhao2014@163.com.
authors.forename: Shuming
authors.initials: S
authors.lastname: Zhao
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism / Q000382:microbiology*; D006801:Humans; D015539:Platelet Activation; D010974:Platelet Aggregation; D013290:Streptococcal Infections / Q000473:pathology*; D013291:Streptococcus / Q000378:metabolism / Q000472:pathogenicity
chemical_list: D001426:Bacterial Proteins