title: Short Communication: Diversity of TNF-α region in Chinese domestic goats.
abstract: Tumor necrosis factor-α is a cytokine with a wide range of effects on both lymphoid and non-lymphoid cells. In this study, we identified polymorphisms in major histocompatibility complex class III gene in the 4th exon and the 3' untranslated region of tumor necrosis factor-α to evaluate the immunogenetic diversity of Chinese south indigenous goat. Three single-nucleotide polymorphisms were identified and showed similar frequencies in different except MI loci. These data suggest that the high immunodiversity of the tumor necrosis factor-α region within these breeds can be used for strengthening variety improvement and promoting animal husbandry development in Chinese indigenous goats.
authors.affiliation: College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: G X
authors.initials: GX
authors.lastname: E
authors.affiliation: College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: R S
authors.initials: RS
authors.lastname: Na
authors.affiliation: College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Zhao
authors.affiliation: Department of Animal Genetic Resources, Institute of Animal Science.
authors.forename: Y H
authors.initials: YH
authors.lastname: Ma
authors.affiliation: College of Animal Science and Technology, Chongqing Key Laboratory of Forage & Herbivore, Chongqing Engineering Research Centre for Herbivores Resource Protection and Utilization, Southwest University, Chongqing, China H67738337@swu.edu.cn.
authors.forename: Y F
authors.initials: YF
authors.lastname: Huang
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D002681:China; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D005843:Geography; D006041:Goats / Q000235:genetics*; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; D014409:Tumor Necrosis Factor-alpha