title: Femoral lipectomy increases postprandial lipemia in women.
abstract: Femoral subcutaneous adipose tissue (SAT) appears to be cardioprotective compared with abdominal SAT, possibly through better triglyceride (TG) sequestration. We hypothesized that removal of femoral SAT would increase postprandial TG through a reduction in dietary fatty acid (FA) storage. Normal-weight (means ± SD; BMI 23.9 ± 2.6 kg/m(2)) women (n = 29; age 45 ± 6 yr) were randomized to femoral lipectomy (LIPO) or control (CON) and followed for 1 yr. Regional adiposity was measured by DEXA and CT. A liquid meal labeled with [(14)C]oleic acid was used to trace the appearance of dietary FA in plasma (6-h postprandial TG), breath (24-h oxidation), and SAT (24-h [(14)C]TG storage). Fasting LPL activity was measured in abdominal and femoral SAT. DEXA leg fat mass was reduced after LIPO vs. CON (Δ-1.4 ± 0.7 vs. 0.1 ± 0.5 kg, P < 0.001) and remained reduced at 1 yr (-1.1 ± 1.4 vs. -0.2 ± 0.5 kg, P < 0.05), as did CT thigh subcutaneous fat area (-39.6 ± 36.6 vs. 4.7 ± 14.6 cm(2), P < 0.05); DEXA trunk fat mass and CT visceral fat area were unchanged. Postprandial TG increased (5.9 ± 7.7 vs. -0.6 ± 5.3 × 10(3) mg/dl, P < 0.05) and femoral SAT LPL activity decreased (-21.9 ± 22.3 vs. 10.5 ± 26.5 nmol·min(-1)·g(-1), P < 0.05) 1 yr following LIPO vs. CON. There were no group differences in (14)C-labeled TG appearing in abdominal and femoral SAT or elsewhere. In conclusion, femoral fat remained reduced 1 yr following lipectomy and was accompanied by increased postprandial TG and reduced femoral SAT LPL activity. There were no changes in storage of meal-derived FA or visceral fat. Our data support a protective role for femoral adiposity on circulating TG independent of dietary FA storage and visceral adiposity.
authors.affiliation: Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, College of Nursing, and.
authors.forename: Teri L
authors.initials: TL
authors.lastname: Hernandez
authors.affiliation: Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes, Denver Health and Hospital Authority, Denver, Colorado; and.
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Bessesen
authors.affiliation: Department of Nutrition, Colorado State University, Fort Collins, Colorado.
authors.forename: Kimberly A
authors.identifier: http://orcid.org/0000-0002-5904-1793
authors.initials: KA
authors.lastname: Cox-York
authors.affiliation: Department of Medicine, Division of Geriatric Medicine.
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Erickson
authors.affiliation: Department of Dermatology, Cosmetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado;
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Law
authors.affiliation: Department of Medicine, Division of Geriatric Medicine.
authors.forename: Molly K
authors.initials: MK
authors.lastname: Anderson
authors.affiliation: Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Medicine, Division of Endocrinology, Metabolism, and Diabetes.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Jackman
authors.affiliation: Department of Medicine, Division of Geriatric Medicine, rachael.vanpelt@ucdenver.edu.
authors.forename: Rachael E
authors.identifier: http://orcid.org/0000-0003-4187-7063
authors.initials: RE
authors.lastname: Van Pelt
mesh_terms: D050154:Adiposity / Q000502:physiology; D000328:Adult; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology*; D015187:Lipectomy / Q000379:methods; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood; D019518:Postprandial Period; D050151:Subcutaneous Fat / Q000601:surgery*; D050507:Subcutaneous Fat, Abdominal / Q000601:surgery; D013848:Thigh / Q000601:surgery*; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides
keywords: adipose tissue; dietary fatty acids; liposuction; triglycerides