title: Donor caveolin 1 (CAV1) genetic polymorphism influences graft function after renal transplantation.
abstract: BACKGROUND
  Identification of the culprit genes underlying multifactorial diseases is one of the most important current challenges of molecular genetics. While recent advances in genomics research have accelerated the discovery of susceptibility genes, much remains to be learned about the functions of disease-associated genetic variants. Recently, Moore and co-workers identified, in the donor genome, an association between a common genetic variant (rs4730751) in the gene encoding caveolin-1 (CAV1), a major structural component of caveolae, and long-term allograft survival.
  
  
  METHODS
  Four hundred seventy-five renal recipients consecutively transplanted were included in this study. Donor genomic DNA was extracted and used to genotype CAV1 rs4730751 Single Nucleotide Polymorphism.
  
  
  RESULTS
  Patients receiving a graft carrying CAV1 rs4730751 AA genotype displayed a significant decrease in estimated glomerular filtration rate and a significant increase in serum creatinine in both univariate and multivariate analyzes. Moreover, patients receiving a graft with CAV1 AA genotype significantly developed more interstitial fibrosis lesions on systematic biopsies performed 3 months post-transplantation.
  
  
  CONCLUSIONS
  Genotyping of CAV1 may be relevant to identify patients at risk of adverse renal transplant outcome.
authors.affiliation: EA4483, Département de Biochimie et Biologie Moléculaire, Faculté de Médecine, Pôle Recherche, Université de Lille, 1 place de Verdun, Lille Cedex, 59045 France.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Van der Hauwaert
authors.affiliation: EA4483, Département de Biochimie et Biologie Moléculaire, Faculté de Médecine, Pôle Recherche, Université de Lille, 1 place de Verdun, Lille Cedex, 59045 France.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Savary
authors.affiliation: Laboratoire de Biomathématiques, Faculté des Sciences Pharmaceutiques, Université de Lille, 3 rue du Professeur Laguesse - BP 83, 59006 Lille Cedex, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Pinçon
authors.affiliation: Institut de Pathologie, Centre de Biologie Pathologie Génétique, CHRU, Boulevard du Professeur Jules Leclercq, 59037 Lille Cedex, France.
authors.forename: Viviane
authors.initials: V
authors.lastname: Gnemmi
authors.affiliation: Service de Néphrologie, Hôpital Huriez, CHRU, 2 avenue Oscar Lambret, 59037 Lille Cedex, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Noël
authors.affiliation: EA4483, Département de Biochimie et Biologie Moléculaire, Faculté de Médecine, Pôle Recherche, Université de Lille, 1 place de Verdun, Lille Cedex, 59045 France.
authors.forename: Franck
authors.initials: F
authors.lastname: Broly
authors.affiliation: Service d'Immunologie, Centre de Biologie Pathologie Génétique, CHRU, Boulevard du Professeur Jules Leclercq, 59037 Lille Cedex, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Labalette
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, U837, Jean-Pierre Aubert Research Center, Equipe 5 "Mucines, Différenciation et Cancérogenèse Épithéliales", 1 place de Verdun, 59045 Lille Cedex, France.
authors.forename: Michaël
authors.initials: M
authors.lastname: Perrais
authors.affiliation: EA4483, Département de Biochimie et Biologie Moléculaire, Faculté de Médecine, Pôle Recherche, Université de Lille, 1 place de Verdun, Lille Cedex, 59045 France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pottier
authors.affiliation: EA4483, Département de Biochimie et Biologie Moléculaire, Faculté de Médecine, Pôle Recherche, Université de Lille, 1 place de Verdun, Lille Cedex, 59045 France ; Service de Néphrologie, Hôpital Huriez, CHRU, 2 avenue Oscar Lambret, 59037 Lille Cedex, France.
authors.forename: François
authors.initials: F
authors.lastname: Glowacki
authors.affiliation: EA4483, Département de Biochimie et Biologie Moléculaire, Faculté de Médecine, Pôle Recherche, Université de Lille, 1 place de Verdun, Lille Cedex, 59045 France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Cauffiez