title: Binding of Anticell Adhesive Oxime-Crosslinked PEG Hydrogels to Cardiac Tissues.
abstract: Postsurgical cardiac adhesions increase the number of surgeries as well as patient mortality and morbidity. A fast gelling oxime-crosslinked PEG hydrogel with tunable gelation time, degradation, and mechanical properties is presented. This material is cytocompatible and prevents cellular adhesion. Material retention on different cardiac tissues is demonstrated ex vivo over time and that functional group ratio alters material retention on different cardiac tissues.
authors.affiliation: Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California, San Diego, CA, 92037, USA.
authors.forename: Gregory N
authors.initials: GN
authors.lastname: Grover
authors.affiliation: Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California, San Diego, CA, 92037, USA.
authors.forename: Julian
authors.initials: J
authors.lastname: Garcia
authors.affiliation: Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California, San Diego, CA, 92037, USA.
authors.forename: Mary M
authors.initials: MM
authors.lastname: Nguyen
authors.affiliation: Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California, San Diego, CA, 92037, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Zanotelli
authors.affiliation: Department of Surgery, University of California, San Diego, CA, 92093, USA.
authors.forename: Michael M
authors.initials: MM
authors.lastname: Madani
authors.affiliation: Department of Bioengineering and Sanford Consortium for Regenerative Medicine, University of California, San Diego, CA, 92037, USA.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Christman
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology*; D010091:Oximes / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D020100:Hydrogels; D010091:Oximes; D011092:Polyethylene Glycols; C000595209:polyethylene glycol 1000
keywords: cardiac surgery; hydrogels; postsurgical adhesions