title: A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity.
abstract: The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the CN may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells.
authors.affiliation: Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
authors.forename: Lea
authors.initials: L
authors.lastname: Ankri
authors.affiliation: Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France.
authors.forename: Zoé
authors.initials: Z
authors.lastname: Husson
authors.affiliation: Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Pietrajtis
authors.affiliation: Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France.
authors.forename: Rémi
authors.identifier: http://orcid.org/0000-0002-5829-1344
authors.initials: R
authors.lastname: Proville
authors.affiliation: Centre national de la recherche scientifique, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France.
authors.forename: Clément
authors.initials: C
authors.lastname: Léna
authors.affiliation: Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
authors.forename: Yosef
authors.initials: Y
authors.lastname: Yarom
authors.affiliation: Inhibitory Transmission Team, Institut de Biologie de l'École Normale Supérieure, Ecole Normale Supérieure, Paris, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Dieudonné
authors.affiliation: Department of Neurobiology, Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
authors.forename: Marylka Yoe
authors.initials: MY
authors.lastname: Uusisaari
mesh_terms: D000818:Animals; D002525:Cerebellar Cortex / Q000502:physiology*; D002529:Cerebellar Nuclei / Q000166:cytology* / Q000502:physiology; D007150:Immunohistochemistry; D007395:Interneurons / Q000502:physiology*; D008164:Luminescent Proteins; D051379:Mice; D008959:Models, Neurological; D009434:Neural Pathways / Q000502:physiology*; D062308:Optogenetics; D000097573:Red Fluorescent Protein
chemical_list: D008164:Luminescent Proteins; D000097573:Red Fluorescent Protein
keywords: Golgi cells; cerebellar nuclei; cerebellum; inhibition; mouse; neuroscience