title: Why do high-volume hospitals achieve better outcomes? A systematic review about intermediate factors in volume-outcome relationships.
abstract: OBJECTIVE
  To assess the role of process and structural factors in volume-outcome relationships.
  
  
  METHODS
  Pubmed electronic database, until March 2014.
  
  
  METHODS
  Systematic review. Based on a conceptual framework, peer-reviewed publications were included that presented evidence about explanatory factors in volume-outcome associations.
  
  
  METHODS
  Two reviewers extracted information about study design, study population, volume and outcome measures, as well as explanatory factors. Included publications were appraised for methodological quality.
  
  
  RESULTS
  After screening 1756 titles, 27 met our inclusion criteria. Three main categories of explanatory factors could be identified: 1. Compliance to evidence based processes of care (n = 7). 2. Level of specialization (n = 11). 3. Hospital level factors (n = 10). In ten studies, process and/or structural characteristics partly explained the established volume-outcome association. The median quality score of the 27 studies was 8 out of a possible 18 points.
  
  
  CONCLUSIONS
  The vast majority of volume-outcome studies do not focus on the underlying mechanism by including process and structural characteristics as explanatory factors in their analysis. The methodological quality of studies is also modest, which makes us question the available evidence for current policies to concentrate care on the basis of volume.
authors.affiliation: Tias School for Business and Society, Tilburg University, Tilburg, The Netherlands; Reinier Haga Groep, Delft/Den Haag, The Netherlands. Electronic address: roos.mesman@gmail.com.
authors.forename: Roos
authors.initials: R
authors.lastname: Mesman
authors.affiliation: Radboud University Medical Center, Scientific Institute for Quality of Healthcare (IQ healthcare), Nijmegen, The Netherlands.
authors.forename: Gert P
authors.initials: GP
authors.lastname: Westert
authors.affiliation: Tias School for Business and Society, Tilburg University, Tilburg, The Netherlands; Elisabeth Tweesteden ziekenhuis, Tilburg, The Netherlands.
authors.forename: Bart J M M
authors.initials: BJ
authors.lastname: Berden
authors.affiliation: Radboud University Medical Center, Scientific Institute for Quality of Healthcare (IQ healthcare), Nijmegen, The Netherlands.
authors.forename: Marjan J
authors.initials: MJ
authors.lastname: Faber
mesh_terms: D006742:Hospital Bed Capacity / Q000592:standards / Q000706:statistics & numerical data; D006761:Hospitals / Q000592:standards / Q000706:statistics & numerical data; D061847:Hospitals, High-Volume / Q000592:standards* / Q000706:statistics & numerical data; D006801:Humans; D011787:Quality of Health Care / Q000706:statistics & numerical data; D016896:Treatment Outcome
keywords: Health care policy; Quality improvement; Selective purchasing; Systematic review; Volume–outcome relationships