title: Risk factors for extensive drug-resistance and mortality in geriatric inpatients with bacteremia caused by Acinetobacter baumannii.
abstract: BACKGROUND
  The aim of this study was to explore the risk factors for developing bacteremia caused by extensive drug-resistant (XDR) Acinetobacter baumannii and the associated mortality in geriatric inpatients.
  
  
  METHODS
  We conducted a retrospective study of 125 patients with A baumannii bacteremia between October 2008 and December 2013 at a medical center in China.
  
  
  RESULTS
  The 30-day hospital mortality rate was 55.2%. XDR A baumannii was detected in 31.2% of all cases. A logistic regression analysis suggested that chronic obstructive pulmonary disease, a bedridden status, and central venous catheters were associated with bacteremia caused by XDR A baumannii, with adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of 2.59 (1.01-6.64), 4.08 (1.39-12.01), and 9.52 (1.90-47.56), respectively. Furthermore, intensive care unit (ICU) stay, bacteremia caused by XDR A baumannii, concurrent fungal infection, and age (70-80 years old and >80 years old) were associated with mortality, with aORs and 95% CIs of 3.16 (1.29-7.73), 4.01 (1.46-11.04), 3.20 (1.28-7.98), 4.31 (1.44-12.92), and 5.46 (1.94-15.35), respectively.
  
  
  CONCLUSIONS
  Bacteremia is associated with a high 30-day hospital mortality rate in geriatric inpatients. Furthermore, ICU stay, bacteremia caused by XDR A baumannii, concurrent fungal infection, and age are associated with increased mortality in geriatric inpatients with A baumannii bacteremia.
authors.affiliation: Department of Infectious Diseases, FuXing Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: Department of Infectious Diseases, FuXing Hospital, Capital Medical University, Beijing, PR China. Electronic address: yedahuan01@126.com.
authors.forename: Huan
authors.initials: H
authors.lastname: Ye
authors.affiliation: Department of Microbiology and Clinical Laboratory, FuXing Hospital, Capital Medical University, Beijing, PR China.
authors.forename: Shumei
authors.initials: S
authors.lastname: Liu
mesh_terms: D000151:Acinetobacter Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality*; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000302:isolation & purification; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality*; D002681:China / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D015994:Incidence; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
keywords: Acinetobacter baumannii; Bacteremia; Extensive drug resistance; Geriatric inpatients; Risk factors