title: Shedding light on inflammatory pseudotumor in children: spotlight on inflammatory myofibroblastic tumor.
abstract: Inflammatory pseudotumor is a generic term used to designate a heterogeneous group of inflammatory mass-forming lesions histologically characterized by myofibroblastic proliferation with chronic inflammatory infiltrate. Inflammatory pseudotumor is multifactorial in etiology and generally benign, but it is often mistaken for malignancy given its aggressive appearance. It can occur throughout the body and is seen in all age groups. Inflammatory pseudotumor has been described in the literature by many organ-specific names, resulting in confusion. Recently within this generic category of inflammatory pseudotumor, inflammatory myofibroblastic tumor has emerged as a distinct entity and is now recognized as a fibroblastic/myofibroblastic neoplasm with intermediate biological potential and occurring mostly in children. We present interesting pediatric cases of inflammatory myofibroblastic tumors given this entity's tendency to occur in children. Familiarity and knowledge of the imaging features of inflammatory pseudotumor can help in making an accurate diagnosis, thereby avoiding unnecessary radical surgery.
authors.affiliation: Department of Radiology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Room 3970 JPP, Iowa City, IA, 52242, USA. lillian.lai@gmail.com.
authors.forename: Lillian M
authors.initials: LM
authors.lastname: Lai
authors.affiliation: Department of Radiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
authors.forename: M Beth
authors.initials: MB
authors.lastname: McCarville
authors.affiliation: Department of Pathology, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
authors.forename: Patricia
authors.initials: P
authors.lastname: Kirby
authors.affiliation: Department of Radiology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Room 3970 JPP, Iowa City, IA, 52242, USA.
authors.forename: Simon C S
authors.initials: SC
authors.lastname: Kao
authors.affiliation: Department of Radiology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Room 3970 JPP, Iowa City, IA, 52242, USA.
authors.forename: Toshio
authors.initials: T
authors.lastname: Moritani
authors.affiliation: Department of Radiology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Room 3970 JPP, Iowa City, IA, 52242, USA.
authors.forename: Eve
authors.initials: E
authors.lastname: Clark
authors.affiliation: Department of Radiology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Room 3970 JPP, Iowa City, IA, 52242, USA.
authors.forename: Kousei
authors.initials: K
authors.lastname: Ishigami
authors.affiliation: Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
authors.forename: Armita
authors.initials: A
authors.lastname: Bahrami
authors.affiliation: Department of Radiology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Room 3970 JPP, Iowa City, IA, 52242, USA.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sato
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D006104:Granuloma, Plasma Cell / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed
keywords: Children; Computed tomography; Inflammatory myofibroblastic tumor; Inflammatory pseudotumor; Magnetic resonance imaging; pediatric fibrous tumor