title: CtIP: A DNA damage response protein at the intersection of DNA metabolism.
abstract: The mammalian CtIP protein and its orthologs in other eukaryotes promote the resection of DNA double-strand breaks and are essential for meiotic recombination. Here we review the current literature supporting the role of CtIP in DNA end processing and the importance of CtIP endonuclease activity in DNA repair. We also examine the regulation of CtIP function by post-translational modifications, and its involvement in transcription- and replication-dependent functions through association with other protein complexes. The tumor suppressor function of CtIP likely is dependent on a combination of these roles in many aspects of DNA metabolism.
authors.affiliation: The Howard Hughes Medical Institute, The Department of Molecular Genetics and Microbiology, The Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA.
authors.forename: Nodar
authors.initials: N
authors.lastname: Makharashvili
authors.affiliation: The Howard Hughes Medical Institute, The Department of Molecular Genetics and Microbiology, The Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: tpaull@utexas.edu.
authors.forename: Tanya T
authors.initials: TT
authors.lastname: Paull
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D053904:DNA Breaks, Single-Stranded; D059766:DNA End-Joining Repair; D004277:DNA, Single-Stranded / Q000737:chemistry / Q000378:metabolism; D004706:Endodeoxyribonucleases; D004720:Endonucleases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D059765:Homologous Recombination; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D004277:DNA, Single-Stranded; D009687:Nuclear Proteins; C107849:SAE2 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D025521:Tumor Suppressor Proteins; D004247:DNA; D004706:Endodeoxyribonucleases; D004720:Endonucleases; C410741:RBBP8 protein, human
keywords: CtIP; DNA damage response; Double-strand break; Mre11/Rad50/Nbs1; Resection