title: The etiology of lenticulostriate vasculopathy and the role of congenital infections.
abstract: Lenticulostriate vasculopathy (LSV) refers to increased echogenicity of the penetrating vessels that supply the basal ganglia and segments of the internal capsule seen on cranial ultrasound. Initially identified in infants with congenital infection, LSV has now been associated with a variety of infectious and non-infectious conditions. Although robust epidemiologic studies are lacking, the available evidence does not support broad evaluation for multiple congenital infections when LSV is identified. We propose screening infants with LSV for congenital cytomegalovirus infection and ensuring that prenatal screening included appropriate testing for syphilis, human immunodeficiency virus, and rubella-immune status. Large, prospective observational studies are needed to determine the incidence of LSV and the relative contribution of infectious and non-infectious conditions to LSV in the neonate.
authors.affiliation: Department of Pediatrics, Division of NeonatalPerinatal Medicine, University of Texas Southwestern Medical Center, United States; Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Texas Southwestern Medical Center, United States. Electronic address: joseph.cantey@utsouthwestern.edu.
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Cantey
authors.affiliation: Department of Pediatrics, Division of NeonatalPerinatal Medicine, University of Texas Southwestern Medical Center, United States.
authors.forename: Julide
authors.initials: J
authors.lastname: Sisman
mesh_terms: D001479:Basal Ganglia / Q000000981:diagnostic imaging*; D020144:Basal Ganglia Cerebrovascular Disease / Q000000981:diagnostic imaging / Q000209:etiology*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000151:congenital* / Q000000981:diagnostic imaging; D004453:Echoencephalography; D006801:Humans; D007231:Infant, Newborn; D011296:Prenatal Diagnosis
keywords: Cytomegalovirus; Infection; Ultrasound