title: Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice.
abstract: We investigated the effects of Hericium erinaceus (HEM) on liver injury induced by acute alcohol administration in mice. Mice received ethanol (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses. HEM (200 mg/kg BW) was gavage before ethanol administration. Subsequent serum alanine aminotransferase (ALT) level, aspartate aminotransaminase (AST) level, Maleic dialdehyde (MDA) level, hepatic total antioxidant status (TAOS), and activated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) were determined by ELISA and immunohistochemistry, respectively. HEM administration markedly (P < 0.05) decreased serum ALT, AST, and MDA levels. The hepatic histopathological observations showed that HEM had a relatively significant role in mice model, which had alcoholic liver damage. In conclusion, we observed that HEM (200 mg/kg BW) supplementation could restrain the hepatic damage caused by acute alcohol exposure.
authors.affiliation: Department of Gastroenterology, Tangshan Gongren Hospital, Tangshan 06300, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Hao
authors.affiliation: Department of Intensive Care Unit, Hebei United University Affiliated Hospital, Tangshan 06300, China.
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Gastroenterology, Tangshan Gongren Hospital, Tangshan 06300, China.
authors.forename: Guikai
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of Intensive Care Unit, Hebei United University Affiliated Hospital, Tangshan 06300, China.
authors.forename: Aibin
authors.initials: A
authors.lastname: Cheng
authors.affiliation: Department of Hepatobiliary Surgery, Tangshan Gongren Hospital, Tangshan 06300, China.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Tangshan Gongren Hospital, Tangshan 06300, China.
authors.forename: Rongjuan
authors.initials: R
authors.lastname: Zheng
authors.affiliation: Department of Gastroenterology, Tangshan Gongren Hospital, Tangshan 06300, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Huo
authors.affiliation: Department of Intensive Care Unit, Hebei United University Affiliated Hospital, Tangshan 06300, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Zhang