title: [Meta-analysis of PET/CT for diagnosis of residual/recurrent nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To assess the diagnostic value of 18-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in detecting residual/recurrent nasopharyngeal carcinoma.
  
  
  METHODS
  The literatures published between January 1990 and September 2013 were searched in PubMed, EM-BASE, EBSCO, Web of Science, CBM, CNKI, VIP and Wanfang databases. Two researchers independently selected studies, extracted data and assessed the quality of included studies according to the QUADAS tool. Summary sensitivity, specificity, diagnostic odds ratios (DOR), and receiver-operating characteristic (SROC) curves were obtained using Meta-Disc software. Subgroup analysis was also conducted.
  
  
  RESULTS
  Twenty-six studies were included in this meta-analysis, involving 1203 patients. The pooled sensitivity, specificity and DOR were 0. 92 (95% CI:0.89-0.94), 0. 87 (95% CI:0.84-0.90) and 51. 10 (95% CI:34.29-76.15), respectively. The area under the curve (AUC) and Q index estimate for PET/CT were 0. 9494 and 0. 8897, respectively. The results of subgroup analysis showed no significant differences between subgroups(P>0.05).
  
  
  CONCLUSIONS
  In a word, 18F-FDG PET/CT performed well for diagnosis of residual/recurrent nasopharyngeal carcinoma, with relatively high sensitivity and specificity.
authors.forename: Guohua
authors.initials: G
authors.lastname: Shen
authors.forename: Lvyi
authors.initials: L
authors.lastname: Zhou
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Jia
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zhang
authors.forename: Qiao
authors.initials: Q
authors.lastname: Wang
authors.forename: Houfu
authors.initials: H
authors.lastname: Deng
mesh_terms: D002277:Carcinoma; D019788:Fluorodeoxyglucose F18; D006801:Humans; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D012372:ROC Curve; D019275:Radiopharmaceuticals; D012008:Recurrence; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18