title: Curcumin Ameliorates Lead (Pb(2+))-Induced Hemato-Biochemical Alterations and Renal Oxidative Damage in a Rat Model.
abstract: This study aims to evaluate the protective role of curcumin (Curc) against hematological and biochemical changes, as well as renal pathologies induced by lead acetate [Pb (CH3COO)2·3H2O] treatment. Male albino rats were intraperitoneally treated with Pb(2+) (25 mg of lead acetate/kg b.w., once a day) alone or in combination with Curc (30 mg of Curc/kg b.w., twice a day) for 7 days. Exposure of rats to Pb(2+) caused significant decreases in hemoglobin (Hb) content, hematocrit (Ht) value, and platelet (Plt) count, while Pb(2+)-related leukocytosis was accompanied by absolute neutrophilia, monocytosis, lymphopenia, and eosinopenia. A significant rise in lipid peroxidation (LPO) and a marked drop of total antioxidant capacity (TAC) were evident in the kidney, liver, and serum of Pb(2+) group compared to that of control. Furthermore, significantly high levels of total cholesterol (TC), triglycerides (TGs), and low-density lipoprotein cholesterol (LDL-C), and a sharp drop in serum high-density lipoprotein (HDL-C) level were also seen in blood after injection of Pb(2+). Additionally, hepatorenal function tests were enhanced. Meanwhile, Pb(2+) produced marked histo-cytological alterations in the renal cortex. Co-administration of Curc to the Pb(2+)-treated animals restored most of the parameters mentioned above to near-normal levels/features. In conclusion, Curc appeared to be a promising agent for protection against Pb(2+)-induced toxicity.
authors.affiliation: Department of Biological Sciences, Faculty of Science, King Faisal University, Al-Hassa, PO box 380, Saudi Arabia. aabdelmoneim@kfu.edu.sa.|Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt. aabdelmoneim@kfu.edu.sa.
authors.forename: Ashraf M
authors.initials: AM
authors.lastname: Abdel-Moneim
authors.affiliation: Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt.|Preparatory Year Program, King Faisal University, Al-Hassa, Saudi Arabia.
authors.forename: Mona Y
authors.initials: MY
authors.lastname: El-Toweissy
authors.affiliation: Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt.
authors.forename: Awatef M
authors.initials: AM
authors.lastname: Ali
authors.affiliation: Biology and Geology Department, Faculty of Education, Alexandria University, Alexandria, Egypt.
authors.forename: Abd Allah M
authors.initials: AA
authors.lastname: Awad Allah
authors.affiliation: Biology and Geology Department, Faculty of Education, Alexandria University, Alexandria, Egypt.
authors.forename: Hanaa S
authors.initials: HS
authors.lastname: Darwish
authors.affiliation: Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt.
authors.forename: Ismail A
authors.initials: IA
authors.lastname: Sadek
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001772:Blood Cell Count; D003474:Curcumin / Q000627:therapeutic use*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D007677:Kidney Function Tests; D007854:Lead / Q000378:metabolism; D007855:Lead Poisoning / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress; D010976:Platelet Count; D051381:Rats
chemical_list: D000975:Antioxidants; D006454:Hemoglobins; D007854:Lead; D003474:Curcumin
keywords: Curcumin; Hematotoxicity; Hyperlipidemia; Lead acetate; Nephrotoxicity; Oxidative stress