title: Increased risk of renal biopsy complications in patients with IgA-nephritis.
abstract: BACKGROUND
  The aim of this study was to investigate if specific clinical and histological findings can be related to biopsy complications to enable more closely monitoring patients at high risk.
  
  
  METHODS
  Results from 1081 biopsies (994 patients, median age 54.5 years; 896 native and 185 transplant kidney biopsies) were included. Diagnostic quality, morphology, clinical data and complications were prospectively registered.
  
  
  RESULTS
  In native kidney biopsies, the most common diagnosis was IgA-nephritis, while in transplant kidney biopsies it was rejection. Patients with IgA-nephritis had a higher risk of major complications (11.7 versus 6.4 %, Odds Ratio (OR) 1.8, Confidence Interval (CI) 1.1-3.2) when compared to patients with other diseases. In native kidney biopsies, patients who experienced major complications had higher degrees of glomerulosclerosis (31 versus 20 %, p = 0.008), whereas in transplant kidney biopsies, patients had higher degrees of interstitial fibrosis (82 versus 33 %, p < 0.001) when compared to patients without major complications. IgA-nephritis-patients had a higher risk of re-biopsies (4.7 versus 1.3 %, OR 4, CI 1.5-11) than patients with other diseases. Patients with native kidneys who needed re-biopsies were younger (42.6 versus 52.3 years, p = 0.031) and had a higher degree of interstitial fibrosis (63 versus 34 %, p = 0.046).
  
  
  CONCLUSIONS
  Patients with IgA-nephritis have an increased risk of major biopsy complications. The risk of re-biopsies was higher in younger individuals and in patients with IgA-nephritis.
authors.affiliation: Department of Nephrology, Skaraborgs Hospital, 541 85, Skövde, Sweden. bjorn.peters@vgregion.se.
authors.forename: Björn
authors.initials: B
authors.lastname: Peters
authors.affiliation: Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
authors.forename: Bernd
authors.initials: B
authors.lastname: Stegmayr
authors.affiliation: Department of Nephrology, Skaraborgs Hospital, 541 85, Skövde, Sweden.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Andersson
authors.affiliation: Department of Nephrology, Skaraborgs Hospital, 541 85, Skövde, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Hadimeri
authors.affiliation: Department of Pathology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Mölne
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000009:adverse effects*; D005260:Female; D005355:Fibrosis; D005922:Glomerulonephritis, IGA / Q000150:complications* / Q000473:pathology; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology / Q000473:pathology; D006084:Graft Rejection / Q000473:pathology; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012306:Risk; D055815:Young Adult
keywords: Biopsy complications; Glomerulosclerosis; IgA-nephritis; Interstitial fibrosis; Kidney biopsy