title: Taste masked thin films printed by jet dispensing.
abstract: Taste masking of bitter active substances is an emerging area in the pharmaceutical industry especially for paediatric/geriatric medications. In this study we introduce the use of jet dispensing as a taste masking technology by printing mucosal thin films of three model bitter substances, Cetirizine HCl, Diphenylhydramine HCl and Ibuprofen. The process was used to dispense aqueous drugs/polymer solutions at very high speed where eventually the drugs were embedded in the polymer matrix. The in vivo evaluation of jet-dispensed mucosal films showed excellent taste masking for drug loadings from 20 to 40%. Jet dispensing was proved to make uniform, accurate and reproducible thin films with excellent content uniformity.
authors.affiliation: Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Scoutaris
authors.affiliation: Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Snowden
authors.affiliation: Faculty of Engineering and Science, University of Greenwich, Medway Campus, Chatham Maritime, Kent ME4 4TB, UK. Electronic address: D.Douroumis@gre.ac.uk.
authors.forename: Dennis
authors.initials: D
authors.lastname: Douroumis
mesh_terms: D000284:Administration, Oral; D017332:Cetirizine / Q000008:administration & dosage; D003199:Computer Systems; D004155:Diphenhydramine / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000295:instrumentation*; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage; D013649:Taste; D013678:Technology, Pharmaceutical / Q000295:instrumentation*
chemical_list: D004155:Diphenhydramine; D007052:Ibuprofen; D017332:Cetirizine
keywords: Jet dispensing; Printing; Taste masking; Water insoluble drugs