title: Midterm clinical outcome following Edwards SAPIEN or Medtronic Corevalve transcatheter aortic valve implantation (TAVI): Results of the Belgian TAVI registry.
abstract: OBJECTIVE
  To assess midterm (3 years) clinical outcomes of transcatheter aortic valve implantation (TAVI) in Belgium using the Edwards SAPIEN valve or the Medtronic CoreValve transcatheter heart valve (THV).
  
  
  BACKGROUND
  Medium and long term follow-up data of both THVs are still relatively scarce, although of great clinical relevance for a relatively new but rapidly expanding treatment modality. Therefore, reporting mid- and long term clinical outcome data, coming from large "real world" national registries, remains contributive.
  
  
  METHODS
  Between December 2007 and March 2012, 861 "real world" patients who were not candidates for surgical aortic valve replacement as decided by the local heart teams, underwent TAVI at 23 sites. Eleven sites exclusively used SAPIEN THV (n = 460), while 12 exclusively used CoreValve THV (n = 401). Differences in clinical outcomes by valve system were assessed, according to access route and baseline EuroSCORE risk profile (<10%: low, 10-20%: intermediate and >20%: high risk).
  
  
  RESULTS
  Overall cumulative survival at 3 years was 51% for SAPIEN vs. 60% for CoreValve (P = 0.021). In transfemorally treated patients, SAPIEN and CoreValve had similar survival at 3 years for each of the baseline EuroSCORE cohorts (low risk: 72% vs. 76%, P = 0.45; intermediate risk: 62% vs. 59%, P = 0.94; high risk: 48% vs. 53%, P = 0.65).
  
  
  CONCLUSIONS
  Cumulative midterm 3 year survival after transfemoral TAVI in "real world" patients refused for surgery with similar baseline EuroSCORE risk profile is not different between SAPIEN or CoreValve.
authors.affiliation: Faculty of Medicine and Health Sciences, Department of Translational Pathophysiological Research, Cardiovascular Diseases, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium.|Department of Cardiology and Cardiac Surgery, Antwerp University Hospital, Edegem, Belgium.
authors.forename: Valérie M
authors.initials: VM
authors.lastname: Collas
authors.affiliation: Department of Cardiology and Cardiac Surgery, University Hospital Leuven, Leuven, Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: Dubois
authors.affiliation: Department of Cardiology, Centre Hospitalier Universitaire De Liege, Liege, Belgium.
authors.forename: Victor
authors.initials: V
authors.lastname: Legrand
authors.affiliation: Department of Cardiology, Cliniques Saint-Luc, University of Louvain, Brussels, Belgium.
authors.forename: Joëlle
authors.initials: J
authors.lastname: Kefer
authors.affiliation: Department of Cardiology, OLV Ziekenhuis, Aalst, Belgium.
authors.forename: Bernard
authors.initials: B
authors.lastname: De Bruyne
authors.affiliation: Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium.
authors.forename: Jo
authors.initials: J
authors.lastname: Dens
authors.affiliation: Department of Cardiology and Cardiac Surgery, Antwerp University Hospital, Edegem, Belgium.
authors.forename: Inez E
authors.initials: IE
authors.lastname: Rodrigus
authors.affiliation: Department of Cardiology and Cardiac Surgery, University Hospital Leuven, Leuven, Belgium.
authors.forename: Paul
authors.initials: P
authors.lastname: Herijgers
authors.affiliation: Faculty of Medicine and Health Sciences, Department of Translational Pathophysiological Research, Cardiovascular Diseases, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium.|Department of Cardiology and Cardiac Surgery, Antwerp University Hospital, Edegem, Belgium.
authors.forename: Johan M
authors.initials: JM
authors.lastname: Bosmans
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000628:therapy*; D001530:Belgium / Q000453:epidemiology; D017548:Echocardiography, Transesophageal; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D012042:Registries; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D065467:Transcatheter Aortic Valve Replacement / Q000379:methods* / Q000401:mortality; D016896:Treatment Outcome
keywords: aortic stenosis; registry; transcatheter aortic valve implantation (TAVI); valvular heart disease