title: An unusual dihydrobenzofuroisocoumarin and ent-kaurane diterpenoids from Pteris multifida.
abstract: An unusual 5-C-methylated-dihydrobenzofuroisocoumarin, named multifidarin A (1), and two new ent-kaurane diterpenoids, named multikauranes A (2) and B (3), together with three known ent-kaurane diterpenoids, were isolated from the whole plants of Pteris multifida. The structures of 1-3 were elucidated by spectroscopic methods. The cytotoxic activities of all new compounds were evaluated against five human tumor cell lines. A possible biosynthetic process for the formation of 1 is proposed.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Materia Medica , Beijing 100050 , China.
authors.forename: Gang
authors.initials: G
authors.lastname: Ni
authors.forename: Nai-Jie
authors.initials: NJ
authors.lastname: Fu
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.forename: Han-Ze
authors.initials: HZ
authors.lastname: Yang
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Chen
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032495:Pteris / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal; C000601409:multifidarin A; C000601410:multikaurane A; C000601411:multikaurane B
keywords: Pteridaceae; Pteris multifida; ent-kaurane diterpenoids; isocoumarin; multifidarin A; multikaurane