title: Genesis of chromatin and transcription dynamics in the origin of species.
abstract: Histone proteins compact and stabilize the genomes of Eukarya and Archaea. By forming nucleosome(-like) structures they restrict access of DNA-binding transcription regulators to cis-regulatory DNA elements. Dynamic competition between histones and transcription factors is facilitated by different classes of proteins including ATP-dependent remodeling enzymes that control assembly, access, and editing of chromatin. Here, we summarize the knowledge on dynamics underlying transcriptional regulation across the domains of life with a focus on ATP-dependent enzymes in chromatin structure or in TATA-binding protein activity. These insights suggest directions for future studies on the evolution of transcription regulation and chromatin dynamics.
authors.affiliation: Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
authors.forename: Maria J E
authors.initials: MJ
authors.lastname: Koster
authors.affiliation: Theoretical Biology and Bioinformatics, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
authors.forename: Berend
authors.initials: B
authors.lastname: Snel
authors.affiliation: Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. Electronic address: h.t.m.timmers@umcutrecht.nl.
authors.forename: H Th Marc
authors.initials: HT
authors.lastname: Timmers
mesh_terms: D001105:Archaea / Q000145:classification / Q000235:genetics / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D056890:Eukaryota / Q000145:classification* / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D010802:Phylogeny; D012319:RNA Polymerase II / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors; D012319:RNA Polymerase II