title: [Thiazide diuretics in the treatment of hypertensive patients].
abstract: This Cochrane review had the objectives to determine the dose-related decrease in blood pressure due to thiazide diuretics compared with placebo control in the treatment of hypertensive patients. Hydrochlorothiazide has a dose-related blood pressure-lowering effect over the dose range 6.25, 12.5, 25 and 50 mg/day of 4/2, 6/3, 8/3 and 11/5 mmHg, respectively. This exceeds the mean 3 mmHg reduction achieved by angiotensin-converting-enzyme inhibitors and angiotensin receptor blockers as shown in other Cochrane reviews, which have compared these antihypertensive drugs with placebo having used similar inclusion/exclusion criteria.
authors.affiliation: Medicinsk Afdeling, Roskilde Sygehus, Køgevej 7-13, 4000 Roskilde. kra@regionsjaelland.dk.
authors.forename: Knud
authors.initials: K
authors.lastname: Rasmussen
mesh_terms: D004232:Diuretics / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D012196:Review Literature as Topic; D012982:Sodium, Dietary / Q000008:administration & dosage; D049971:Thiazides / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004232:Diuretics; D012982:Sodium, Dietary; D049971:Thiazides