title: [Successful treatment with pseudo-autologous blood stem cell transplantation for an adolescent-onset multiple myeloma who relapsed after allogenic bone marrow transplantation].
abstract: A 14-year-old male with multiple myeloma (IgG-λ, ISS stage 3) received myeloablative matched unrelated bone marrow transplantation, and achieved a complete response. At 16 months after the transplantation, he relapsed. The relapse was resistant to bortezomib and thalidomide. Peripheral blood showed mixed chimerism with 10% recipient cells. Peripheral blood stem cells (PBSC) were collected and pseudo-autologous PBSC transplantation (PASCT) was performed following high-dose melphalan without graft-versus-host disease prophylaxis. Hematopoietic recovery was prompt and a partial response was obtained without graft-versus-host disease exacerbation. We have presented a rare case of adolescent-onset multiple myeloma, obtaining a transient response with PASCT following post-allogeneic transplant relapse.
authors.affiliation: Department of Hematology, Japan Community Health Care Organization, Kyoto Kuramaguchi Medical Center.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Hatsuse
authors.forename: Kyoko
authors.initials: K
authors.lastname: Taniguchi-Yoshihara
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yagyu
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Fuchida
authors.forename: Akira
authors.initials: A
authors.lastname: Okano
authors.forename: Satoshi
authors.initials: S
authors.lastname: Murakami
authors.forename: Chihiro
authors.initials: C
authors.lastname: Shimazaki
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000379:methods; D006086:Graft vs Host Disease; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000628:therapy*; D012008:Recurrence; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous / Q000379:methods