title: Distribution of forensic marker allelic frequencies in Pernambuco, Northestern Brazil.
abstract: Pernambuco is one of the 27 federal units of Brazil, ranking seventh in the number of inhabitants. We examined the allele frequencies of 13 short tandem repeat loci (CFS1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, TH01, vWA, and TPOX), the minimum recommended by the Federal Bureau of Investigation and commonly used in forensic genetics laboratories in Brazil, in a sample of 609 unrelated individuals from all geographic regions of Pernambuco. The allele frequencies ranged from 5 to 47.2%. No significant differences for any loci analyzed were observed compared with other publications in other various regions of Brazil. Most of the markers observed were in Hardy-Weinberg equilibrium. The occurrence of the allele 47.2 (locus FGA) and alleles 35.1 and 39 (locus D21S11), also described in a single study of the Brazilian population, was observed. The other forensic parameters analyzed (matching probability, power of discrimination, polymorphic information content, paternity exclusion, complement factor I, observed heterozygosity, expected heterozygosity) indicated that the studied markers are very informative for human forensic identification purposes in the Pernambuco population.
authors.affiliation: Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil sandra.santos@sds.pe.gov.br.
authors.forename: S M
authors.initials: SM
authors.lastname: Santos
authors.affiliation: Laboratório de Perícia e Pesquisa em Genética Forense da Gerência Geral de Polícia Científica da Secretaria de Defesa Social de Pernambuco, Recife, PE, Brasil.
authors.forename: C A
authors.initials: CA
authors.lastname: Souza
authors.affiliation: Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: K C N
authors.initials: KC
authors.lastname: Rabelo
authors.affiliation: Laboratório Genoma, Universidade Federal Rural de Pernambuco, Recife, PE, Brasil.
authors.forename: P R E
authors.initials: PR
authors.lastname: Souza
authors.affiliation: Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: R R
authors.initials: RR
authors.lastname: Moura
authors.affiliation: Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: T C
authors.initials: TC
authors.lastname: Oliveira
authors.affiliation: Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brasil.
authors.forename: S
authors.initials: S
authors.lastname: Crovella
mesh_terms: D001938:Brazil; D016172:DNA Fingerprinting / Q000379:methods*; D053803:Forensic Genetics / Q000379:methods*; D005787:Gene Frequency / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D010334:Paternity; D016133:Polymerase Chain Reaction
chemical_list: D005819:Genetic Markers