title: Short-term risk of cancer among women with previous gestational diabetes: a population-based study.
abstract: OBJECTIVE
  To evaluate the relationship between gestational diabetes (GDM) and incidence of cancer in women within the first decade postpartum.
  
  
  METHODS
  This population-based retrospective cohort study compared the risk of cancer in women with GDM with that of a matched control group comprising pregnant women without diabetes. We included women from Ontario, Canada aged 20-50 years with no history of cancer who had given birth between 1995 and 2008 (N = 149 049). Women with GDM (N = 49 684) were matched on age and year of giving birth, in a ratio of 1:2, to pregnant women without diabetes (N = 99 365).
  
  
  RESULTS
  Over a median 8-year follow-up, there were a total of 2927 (1.5%) cancers. After adjustment for covariates, we found no significant difference in overall risk of cancer between women with GDM and matched control subjects; however, GDM was associated with a significantly greater risk of thyroid cancer (adjusted hazard ratio 1.24, 95% CI 1.05, 1.46) and a significantly lower risk of premenopausal breast cancer (hazard ratio 0.86, 95% CI 0.75, 0.98) compared with matched control subjects.
  
  
  CONCLUSIONS
  This large population-based study did not find a greater risk of cancers among women with GDM during the first decade postpartum; however, GDM was associated with a higher risk of thyroid cancer and a lower risk of premenopausal breast cancer. Further studies are needed to confirm these findings.
authors.affiliation: Department of Medicine, University of Toronto, Toronto, ON, Canada.
authors.forename: S A D
authors.initials: SA
authors.lastname: Bejaimal
authors.affiliation: Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.
authors.forename: C F
authors.initials: CF
authors.lastname: Wu
authors.affiliation: Department of Medicine, University of Toronto, Toronto, ON, Canada.|Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Lowe
authors.affiliation: Department of Medicine, University of Toronto, Toronto, ON, Canada.|Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.|Mount Sinai Hospital, Toronto, ON, Canada.|Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.|Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada.
authors.forename: D S
authors.initials: DS
authors.lastname: Feig
authors.affiliation: Department of Medicine, University of Toronto, Toronto, ON, Canada.|Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.|Sunnybrook Health Sciences Centre, Toronto, ON, Canada.|Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
authors.forename: B R
authors.initials: BR
authors.lastname: Shah
authors.affiliation: Department of Medicine, University of Toronto, Toronto, ON, Canada.|Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.|Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.|Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
authors.forename: L L
authors.initials: LL
authors.lastname: Lipscombe
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D049590:Postpartum Period; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D017697:Premenopause; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000209:etiology*; D019472:Universal Health Insurance; D055815:Young Adult