title: [Clinical Characteristics of antineutrophil cytoplasmic antibody-associated vasculitis in a respiratory diseases referral center in Mexico (1982-2010)].
abstract: BACKGROUND
  Respiratory manifestations in antineutrophil cytoplasmic antibody-associated vasculitis (AASV) are common, though their suspicion is lower than expected in respiratory devoted centers, with few descriptions coming from them.
  
  
  OBJECTIVE
  To describe the clinical, paraclinical and radiological manifestations, plus the prognosis of AASV patients seen in a respiratory referral center in Mexico City.
  
  
  METHODS
  Retrospective review of patients with final diagnosis of AASV, based on the American College of Rheumatology criteria and the 1994 Chapel Hill Consensus Conference Nomenclature, from 1982 to 2010.
  
  
  RESULTS
  The characteristics of 74 granulomatosis with polyangiitis, 10 microscopic polyangiitis, and six eosinophilic granulomatosis with polyangiitis cases are described. Mean time elapsed from initial suspicion to definitive diagnosis was 30 months. As expected, respiratory findings dominated this cohort, but no significant differences were observed when compared to other series with AAS\1, except for a higher frequency of subglottic stenosis. After a mean follow-up of 22 months, 83% of patients were alive, with remission being achieved in 87% and response in 9%. Seven patients died, mostly from infectious complications.
  
  
  CONCLUSIONS
  This study documents that airway manifestations in Mexican patients with AASV are similar to what has been previously described. However, time to diagnosis is long. Respiratory specialists should be more aware of the modes of presentation in AASV patients in order to facilitate their recognition.
authors.affiliation: Clínica de Vasculitis Sistémicas Primarias, Instituto Nacional de Enfermedades Respiratorias (INER), México, D.F., Mexico.
authors.forename: Luis Felipe
authors.initials: LF
authors.lastname: Flores-Suárez
authors.affiliation: Clínica de Vasculitis Sistémicas Primarias, Instituto Nacional de Enfermedades Respiratorias (INER), México, D.F., Mexico.
authors.forename: Marco A
authors.initials: MA
authors.lastname: Alba
mesh_terms: D000328:Adult; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011379:Prognosis; D012120:Respiration Disorders / Q000209:etiology; D012189:Retrospective Studies; D062606:Tertiary Care Centers; D013997:Time Factors