title: Targeting tumor-associated myeloid cells for cancer immunotherapy.
abstract: Tumor-associated myeloid cells undermine the therapeutic efficacy of cancer immunotherapy by their inhibitory properties on immune effector cells. Development of therapeutic agents to deplete suppressive myeloid cells in tumor microenvironment requires identification of cell-specific targets. A competitive phage display technique on live cells paves the way to discovery of such a target.
authors.affiliation: Department of Lymphoma and Myeloma; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA ; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA.
authors.forename: Hong
authors.initials: H
authors.lastname: Qin
authors.affiliation: Department of Lymphoma and Myeloma; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA ; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA.
authors.forename: Guowei
authors.initials: G
authors.lastname: Wei
authors.affiliation: Department of Lymphoma and Myeloma; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA ; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA.
authors.forename: Dongho
authors.initials: D
authors.lastname: Gwak
authors.affiliation: Department of Lymphoma and Myeloma; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA ; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA.
authors.forename: Zhenyuan
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Department of Lymphoma and Myeloma; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA ; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA.
authors.forename: Ailian
authors.initials: A
authors.lastname: Xiong
authors.affiliation: Department of Lymphoma and Myeloma; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA ; Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center ; Houston, TX, USA.
authors.forename: Larry W
authors.initials: LW
authors.lastname: Kwak
keywords: immunosuppression; immunotherapy; myeloid-derived suppressor cells; peptibody; tumor microenvironment