title: Peripapillary choroidal thickness in patients with early age-related macular degeneration and reticular pseudodrusen.
abstract: OBJECTIVE
  The purpose of this study was to investigate peripapillary and macular choroidal thickness (CT) in patients with early age-related macular degeneration (AMD) with or without reticular pseudodrusen (RPD).
  
  
  METHODS
  We investigated the medical records of 89 patients (89 eyes) with early AMD. The eyes were grouped into three categories according to the extent of RPD: no RPD, localized RPD, and diffuse RPD. Peripapillary and macular CT were measured with images obtained by spectral domain optical coherence tomography. CT in the peripapillary and macular areas was compared among groups.
  
  
  RESULTS
  Both RPD groups exhibited an older subject age and a greater female predominance compared to the non-RPD group (P = 0.007 and P = 0.030, respectively). Macular and peripapillary CT were different among the three groups (all, P < 0.001), and both RPD groups showed a thinner choroid in all areas compared to the non-RPD group after adjusting for age and sex (all, P ≤ 0.016). Temporal peripapillary and nasal macular CT at 500 μm and 1500 μm, respectively, from the fovea in eyes with diffuse RPD were significantly thinner than that in eyes with localized RPD (P = 0.008, P = 0.016 and P < 0.001, respectively).
  
  
  CONCLUSIONS
  In addition to the macular area, the peripapillary CT, including the area outside the macula, was thinner in eyes with RPD than in those without RPD. Significant differences in the papillomacular choroid were observed based on RPD distribution type, which suggests that variation in CT is based on the extent of RPD.
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Sungbuk-gu, Seoul, 136-705, Korea.
authors.forename: Cheolmin
authors.initials: C
authors.lastname: Yun
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Sungbuk-gu, Seoul, 136-705, Korea. ojr4991@yahoo.co.kr.
authors.forename: Jaeryung
authors.initials: J
authors.lastname: Oh
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Sungbuk-gu, Seoul, 136-705, Korea.
authors.forename: Soh-Eun
authors.initials: SE
authors.lastname: Ahn
authors.affiliation: Department of Biostatistics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Soon-Young
authors.initials: SY
authors.lastname: Hwang
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Sungbuk-gu, Seoul, 136-705, Korea.
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Sungbuk-gu, Seoul, 136-705, Korea.
authors.forename: Kuhl
authors.initials: K
authors.lastname: Huh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000150:complications* / Q000175:diagnosis; D008297:Male; D009898:Optic Disk; D009929:Organ Size; D015593:Retinal Drusen / Q000150:complications* / Q000175:diagnosis; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence
keywords: Age-related macular degeneration; Choroidal thickness; Drusen; Optical coherence tomography; Peripapillary choroidal thickness; Pseudodrusen