title: Facile synthesis of 4- and 7-azaindoles from the corresponding imines by palladium-catalyzed cascade C-C and C-N coupling.
abstract: The cyclization of 2,3-dihalopyridines with readily available imines provides a convenient and regioselective approach to 4- and 7-azaindoles. The regioselectivity can be controlled by the choice of the halogen atoms at the pyridine ring (chlorine versus bromine).
authors.affiliation: Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany. peter.langer@uni-rostock.de.
authors.forename: Ngo Nghia
authors.initials: NN
authors.lastname: Pham
authors.forename: Thanh Tuan
authors.initials: TT
authors.lastname: Dang
authors.forename: Ngoc Thang
authors.initials: NT
authors.lastname: Ngo
authors.forename: Alexander
authors.initials: A
authors.lastname: Villinger
authors.forename: Peter
authors.initials: P
authors.lastname: Ehlers
authors.forename: Peter
authors.initials: P
authors.lastname: Langer
mesh_terms: D002384:Catalysis; D003500:Cyclization; D054879:Halogenation; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C023422:7-azaindole dimer; D007097:Imines; D007211:Indoles; D011725:Pyridines; D010165:Palladium