title: Cytotoxic compounds from endemic Arnebia purpurea.
abstract: Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-mrutinoside, and kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.
authors.forename: Merve
authors.initials: M
authors.lastname: Yuzbasioglu
authors.forename: Ayse
authors.initials: A
authors.lastname: Kuruuzum-Uz
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Guvenalp
authors.forename: András
authors.initials: A
authors.lastname: Simon
authors.forename: Gabór
authors.initials: G
authors.lastname: Tóth
authors.forename: U Sebnem
authors.initials: US
authors.lastname: Harput
authors.forename: Cavit
authors.initials: C
authors.lastname: Kazaz
authors.forename: Bilgehan
authors.initials: B
authors.lastname: Bilgili
authors.forename: Hayri
authors.initials: H
authors.lastname: Duman
authors.forename: Iclal
authors.initials: I
authors.lastname: Saracoglu
authors.forename: L Omur
authors.initials: LO
authors.lastname: Demirezer
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028082:Boraginaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D005354:Fibrosarcoma / Q000188:drug therapy; D051379:Mice; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009285:Naphthoquinones