title: Hearing voices in the resting brain: A review of intrinsic functional connectivity research on auditory verbal hallucinations.
abstract: Resting state networks (RSNs) are thought to reflect the intrinsic functional connectivity of brain regions. Alterations to RSNs have been proposed to underpin various kinds of psychopathology, including the occurrence of auditory verbal hallucinations (AVH). This review outlines the main hypotheses linking AVH and the resting state, and assesses the evidence for alterations to intrinsic connectivity provided by studies of resting fMRI in AVH. The influence of hallucinations during data acquisition, medication confounds, and movement are also considered. Despite a large variety of analytic methods and designs being deployed, it is possible to conclude that resting connectivity in the left temporal lobe in general and left superior temporal gyrus in particular are disrupted in AVH. There is also preliminary evidence of atypical connectivity in the default mode network and its interaction with other RSNs. Recommendations for future research include the adoption of a common analysis protocol to allow for more overlapping datasets and replication of intrinsic functional connectivity alterations.
authors.affiliation: Department of Psychology, Durham University, Science Laboratories, South Road, Durham DH1 3LE, United Kingdom. Electronic address: benjamin.alderson-day@durham.ac.uk.
authors.forename: Ben
authors.initials: B
authors.lastname: Alderson-Day
authors.affiliation: Department of Cognitive Science, Australian Hearing Hub, Macquarie University, 16 University Avenue, NSW 2109, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: McCarthy-Jones
authors.affiliation: Department of Psychology, Durham University, Science Laboratories, South Road, Durham DH1 3LE, United Kingdom.
authors.forename: Charles
authors.initials: C
authors.lastname: Fernyhough
mesh_terms: D000161:Acoustic Stimulation; D001931:Brain Mapping; D006212:Hallucinations / Q000473:pathology*; D006309:Hearing / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009434:Neural Pathways / Q000503:physiopathology; D012146:Rest; D013702:Temporal Lobe / Q000503:physiopathology*
keywords: Default mode network; Inner speech; Resting state; Schizophrenia; Voice-hearing