title: Association of interleukin-1β -511C/T promoter polymorphism with COPD risk: a meta-analysis.
abstract: Studies examining the role of interleukin (IL)-1β -511C/T promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) have shown inconsistent results. This meta-analysis was performed to assess the association between the IL-1β-511C/T promoter polymorphism and COPD susceptibility. Published case-control, cross-sectional, and cohort studies from Pubmed, Embase, and China National Knowledge Infrastructure databases were retrieved. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Twelve studies with 1692 cases and 2009 controls were included in this meta-analysis. Pooled effect size showed an overall but not significantly decreased risk of IL-1β-511 C/T with COPD susceptibility (OR = 0.89, 95%CI = 0.78-1.01) in a complete overdominant genetic model (TT+CC vs CT), indicating that homozygous individuals (CC and TT) have a decreased risk for COPD compared with heterozygotes (CT). In subgroup analysis by ethnicity, IL-1β-511C/T was significantly correlated with a decreased risk of COPD in Asians (OR = 0.73, 95%CI = 0.60-0.88, P = 0.001), but not in Caucasians (OR = 1.02, 95%CI = 0.83- 1.24, P = 0.46), confirming a protective role of IL-1β-511C/T in COPD in Asians. Moreover, after excluding studies that included populations not in Hardy-Weinberg equilibrium, the pooled results were robust and no publication bias was observed. This meta-analysis suggests that the IL-1β-511C/T promoter polymorphism deceases the risk of COPD in Asians.
authors.affiliation: Department of Respiratory Medicine and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Y S
authors.initials: YS
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, 363 Hospital, Chengdu, Sichuan, China.
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Respiratory Medicine, 363 Hospital, Chengdu, Sichuan, China.
authors.forename: X Y
authors.initials: XY
authors.lastname: Xu
authors.affiliation: Department of Respiratory Medicine, 363 Hospital, Chengdu, Sichuan, China.
authors.forename: J L
authors.initials: JL
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, 363 Hospital, Chengdu, Sichuan, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, 363 Hospital, Chengdu, Sichuan, China.
authors.forename: T L
authors.initials: TL
authors.lastname: Li
authors.affiliation: Department of Respiratory Medicine and Critical Care Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China liang_zongan@163.com.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Liang
mesh_terms: D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C508585:IL1B protein, human; D053583:Interleukin-1beta