title: SpONGE: spontaneous organization of numerous-layer generation by electrospray.
abstract: Advanced technologies that can mimic hierarchical architectures found in nature can provide pivotal clues for elucidating numerous biological mechanisms. Herein, a novel technology, spontaneous organization of numerous-layer generation by electrospray (SpONGE), was developed to create self-assembled and multilayered fibrous structures. The simple inclusion of salts in a polymer solution prior to electrospraying was key to mediating the structural versatilities of the fibrous structures. The SpONGE matrix demonstrated great potential as a crucial building block capable of inducing sequential, localized drug delivery or orchestrating cellular distribution in vivo, thereby expanding its scope of use to cover a variety of biomedical applications.
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 120-749 (Korea).
authors.forename: Gyuhyung
authors.initials: G
authors.lastname: Jin
authors.affiliation: The Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Yuseong-Gu, Daejeon, 305-701 (Korea).
authors.forename: Mikyung
authors.initials: M
authors.lastname: Shin
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 120-749 (Korea).
authors.forename: Seung-Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: The Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Yuseong-Gu, Daejeon, 305-701 (Korea). haeshin@kaist.ac.kr.|Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Yuseong-Gu, Daejeon, 305-701 (Korea). haeshin@kaist.ac.kr.
authors.forename: Haeshin
authors.initials: H
authors.lastname: Lee
authors.affiliation: Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 120-749 (Korea). j-jang@yonsei.ac.kr.
authors.forename: Jae-Hyung
authors.initials: JH
authors.lastname: Jang
keywords: SpONGE; electrospray; inorganic salts; multilayered nanofibers; organic salts