title: NODding off in acute kidney injury with progranulin?
abstract: Zhou et al. identify progranulin (PGRN) as a protective mediator that limits inflammation in murine models of acute kidney injury (AKI) and reduces its severity. Deficiency of PGRN was associated with increased inflammation and increased injury in ischemic and nephrotoxic models of AKI. Exogenous PGRN reduced AKI even when administered after AKI was established. Interference in NOD2 pathways is suggested as a possible mechanism for protection. PGRN-based therapeutics might have application in the treatment or prevention of AKI.
authors.affiliation: Division of Nephrology, Department of Medicine, Penn State Hershey Medical Center and College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: Raghu K
authors.initials: RK
authors.lastname: Tadagavadi
authors.affiliation: Division of Nephrology, Department of Medicine, Penn State Hershey Medical Center and College of Medicine, Hershey, Pennsylvania, USA.
authors.forename: W Brian
authors.initials: WB
authors.lastname: Reeves
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism*; D000818:Animals; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D015427:Reperfusion Injury / Q000378:metabolism*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins