title: [Effect of cadmium chloride on immigration of mouse neural stem cell].
abstract: OBJECTIVE
  To investigate the effects of cadmium chloride on cytoactive and immigration of mouse neural stem cell (mNSC).
  
  
  METHODS
  MTT assay was used to detect cytoactive at 24 hours. The immigration of mNSC was determined by immunofluorescence staining.
  
  
  RESULTS
  Compared with control, CdCl2 treatment at 10.0 μmol/L for 24 h resulted in a decrease in cellular viability (70.08 ± 6.21)% (P < 0.05). Compared with control, Aa/Ab and Dm/Db display decreasing tendency in a dose-dependent manner (r(s Aa/Ab) = - 0.90, γ(s Dm/Db) = - 0.90, P < 0.05) after CdCl2 treatment at 0.1 - 10.0 μmol/L for 24 h.
  
  
  CONCLUSIONS
  Cadmium chloride treatment inhibits immigration of mNSC, and shows negative effect on cell viability. Meanwhile, the effect of cadmium chloride on immigration is more obvious than cell viability at the same concentration for same treatment time.
authors.forename: Yuyuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qunan
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Chai
authors.forename: Zhongzhou
authors.initials: Z
authors.lastname: Shen
authors.forename: Liuwei
authors.initials: L
authors.lastname: Gao
mesh_terms: D000818:Animals; D051379:Mice; D019256:Cadmium Chloride / Q000008:administration & dosage / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D058953:Neural Stem Cells / Q000187:drug effects; D002465:Cell Movement
chemical_list: D019256:Cadmium Chloride