title: [Clinical and Laboratorial Characteristics of Primary Acute Myeloid leukemia with Philadelphia Chromosome and Inversion 16].
abstract: OBJECTIVE
  To summarize the clinical characteristics as well as diagnosis and treatment in 1 case of acute myeloid leukemia(AML) with coexpression of Ph and inv(16).
  
  
  METHODS
  A series of clinical tests, the cellular morphological, immunological, cytogenetic and molecular biological examinations of leukemia cells were performed.
  
  
  RESULTS
  The clinical characteristics of this patient were very common. The cellular morphology is similar to the AML with inv(16). The leukemia cells were stained positively for CD13, CD33, CD34, CD117 and HLA-DR. Karyotypic analysis showed a complex chromosome abnormality including inv(16) and Ph, and the FISH analysis showed that the percentage of rearrangement of CBFβ allele was over that of the BCR-ABL fusion signals. The obvious adverse events did not occur in this patient within 3 years.
  
  
  CONCLUSIONS
  Ph as secondary aberration of inv(16) rarely occures in primary AML cases, and so far there have not been the clear criteria of diagnosis and treatment. The cytogenetic and molecular biology could provide the basis for diagnosis. Moreover, autologous hematopoietic stem cell transplantation combined with imatinib probably is one of the effective treatment methods.
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Collaborated Innovation Center of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Collaborated Innovation Center of Hematology, Suzhou 215000, Jiangsu Province, China. E-mail: yywang2006@163.com.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Wang
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Collaborated Innovation Center of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Zi-Xing
authors.initials: ZX
authors.lastname: Cheng
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Collaborated Innovation Center of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Su-Ning
authors.initials: SN
authors.lastname: Chen
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Collaborated Innovation Center of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Liu
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Collaborated Innovation Center of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Liang
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Collaborated Innovation Center of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Jin-Lan
authors.initials: JL
authors.lastname: Pan
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Collaborated Innovation Center of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Zhu
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Collaborated Innovation Center of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Ding
authors.affiliation: The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Collaborated Innovation Center of Hematology, Suzhou 215000, Jiangsu Province, China. E-mail: cenjiannong@163.com.
authors.forename: Jian-Nong
authors.initials: JN
authors.lastname: Cen
mesh_terms: D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D016044:Fusion Proteins, bcr-abl; D006684:HLA-DR Antigens; D006801:Humans; D015470:Leukemia, Myeloid, Acute; D010677:Philadelphia Chromosome
chemical_list: D006684:HLA-DR Antigens; D016044:Fusion Proteins, bcr-abl