title: Effects of bariatric surgery on incidence of obesity-related cancers: a meta-analysis.
abstract: BACKGROUND
  The aim of this meta-analysis was to investigate possible relationships between bariatric surgery and incidence of obesity-related cancers. Obesity is an established risk factor for obesity-related cancers but the effects of bariatric surgery on incidence of obesity-related cancers are uncertain.
  
  
  METHODS
  We searched 4 electronic databases to identify eligible studies: PubMed, Embase, Web of Science, and Google Scholar. Five observational studies were eligible and included in this meta-analysis. Random-effects or fixed-effects odds ratio (OR) and its corresponding 95% conﬁdence interval (CI) were pooled.
  
  
  RESULTS
  Meta-analysis of these 5 observational studies revealed that bariatric surgery was associated with a significantly (p=0.0004) reduced incidence of obesity-related cancers (OR=0.43, 95%CI, 0.27-0.69) when compared with control individuals. Pooled estimated data showed that bariatric surgery is associated with a 24% lower colorectal cancer (CRC) risk. No publication bias was detected by Egger's or Begg's tests.
  
  
  CONCLUSIONS
  Although bariatric surgery may significantly reduce incidence of obesity-related cancers, considering the limitations of these included studies, these findings should be confirmed by further well-designed studies.
authors.affiliation: Third Xiangya Hospital, Centre South University, Changsha, Hunan, China (mainland).
authors.forename: Xiang-wu
authors.initials: XW
authors.lastname: Yang
authors.affiliation: Third Xiangya Hospital, Centre South University, Changsha, Hunan, China (mainland).
authors.forename: Peng-zhou
authors.initials: PZ
authors.lastname: Li
authors.affiliation: Third Xiangya Hospital, Centre South University, Changsha, Hunan, China (mainland).
authors.forename: Li-yong
authors.initials: LY
authors.lastname: Zhu
authors.affiliation: Third Xiangya Hospital, Centre South University, Changsha, Hunan, China (mainland).
authors.forename: Shaihong
authors.initials: S
authors.lastname: Zhu
mesh_terms: D050110:Bariatric Surgery; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D015986:Confounding Factors, Epidemiologic; D000068598:Data Accuracy; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D009767:Obesity, Morbid / Q000150:complications* / Q000601:surgery; D064887:Observational Studies as Topic / Q000706:statistics & numerical data; D017594:Publication Bias; D012189:Retrospective Studies