title: [Comparison of the incidence and trends of hematologic malignancies between Japan and the United States].
abstract: The incidence of a malignant disease reflects both genetics and the cumulative environmental exposures of a population. Therefore, evaluation of the incidence and trends of a disease in different populations may provide insights into its etiology and pathogenesis. To evaluate the incidence of hematologic malignancies according to specific subtypes, we used population-based registry data in Japan and the United States from 1993 to 2008. The age-adjusted incidence of hematologic malignancies in Japan was approximately one-half that in the United States but has been increasing significantly, whereas no significant change was seen in the United States (annual percent change: Japan, +2.4%; USA, +0.1%). Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) showed the largest incidence differences, with those of chronic lymphocytic leukemia, HL-nodular sclerosis, mycosis fungoides, and cutaneous T-cell lymphoma being the most remarkable. Differences in the incidence and trends for specific subtypes also showed a marked contrast across subtypes which, in turn, may provide novel and significant future insights into disease etiology.
authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute.
authors.forename: Dai
authors.initials: D
authors.lastname: Chihara
authors.forename: Hidemi
authors.initials: H
authors.lastname: Ito
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
mesh_terms: D019337:Hematologic Neoplasms / Q000453:epidemiology*; D006689:Hodgkin Disease / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007564:Japan; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology; D009182:Mycosis Fungoides / Q000453:epidemiology; D012878:Skin Neoplasms / Q000453:epidemiology*; D014481:United States