title: Clinical effects of vinorelbine administration in the management of various malignant tumor types in dogs: 58 cases (1997-2012).
abstract: OBJECTIVE
  To evaluate the effectiveness of vinorelbine in the management of various malignant tumor types in dogs.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  58 dogs with malignant tumors, including pulmonary carcinoma (n = 31), histiocytic sarcoma (9), mast cell tumor (5), lymphoma (4), melanoma (2), and 7 other tumor types (1 each).
  
  
  METHODS
  Medical records of dogs treated with vinorelbine from December 1997 to December 2012 were reviewed for data regarding signalment, clinical signs, physical examination findings, clinicopathologic test results, diagnostic imaging results, vinorelbine doses and dose frequency, surgery and radiotherapy details when applicable, other chemotherapeutics administered, and outcomes. Descriptive, comparative, and survival statistics were computed for all dogs and for dogs by histologic subgroup of tumors.
  
  
  RESULTS
  Vinorelbine was administered palliatively to 44 (76%) dogs. One (2%) dog had a complete response for 162 days, 5 (11%) dogs had a partial response for a median duration of 91 days, 19 (43%) dogs had stable disease for a median duration of 68 days, and 19 (43%) dogs developed progressive disease after a median duration of 21 days. Clinical benefit was more difficult to assess in the remaining 14 (24%) dogs that received vinorelbine as an adjuvant treatment. Overall median time to tumor progression was 103 days (range, 5 to 1,533 days).
  
  
  CONCLUSIONS
  Vinorelbine appeared to be effective in the treatment of several tumor types in dogs. Follow-up prospective studies of the clinical benefit of the drug in specific clinical scenarios will be necessary to support this conclusion.
authors.affiliation: Department of Clinical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706.
authors.forename: Raelene M
authors.initials: RM
authors.lastname: Wouda
authors.forename: Mairin E
authors.initials: ME
authors.lastname: Miller
authors.forename: Esther
authors.initials: E
authors.lastname: Chon
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Stein
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D012189:Retrospective Studies; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine