title: Tumor associated antigens or anti-TAA autoantibodies as biomarkers in the diagnosis of ovarian cancer: a systematic review with meta-analysis.
abstract: OBJECTIVE
  This systematic review aims to outline and summarize known tumor-associated antigens (TAAs) or anti-TAA autoantibodies and their diagnostic values in ovarian cancer (OC).
  
  
  METHODS
  A systematic literature search was conducted in two databases. Data were independently extracted and reviewed by two junior investigators and the disagreement was further resolved by consulting one of the senior investigators.
  
  
  RESULTS
  Sixty publications reporting 113 different TAAs or anti-TAA autoantibodies were included. The majority of the studies were conducted in western countries. CA125, p53 and HE4 were the most frequently tested TAAs in OC. Meta-analysis showed that there was a significant association between serum anti-p53 autoantibody and increased risk of OC.
  
  
  CONCLUSIONS
  Serum TAAs or anti-TAA autoantibodies are promising diagnostic biomarkers in the detection of OC. A customized mini-array of multiple TAAs may enhance the detection of anti-TAA autoantibodies in OC. Additional studies with sufficient number of OC patients and carefully selected controls are needed to further verify the results.
authors.affiliation: Department of Epidemiology, College of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, China.
authors.forename: Jian-Xiang
authors.initials: JX
authors.lastname: Shi
authors.forename: Jie-Jie
authors.initials: JJ
authors.lastname: Qin
authors.forename: Hua
authors.initials: H
authors.lastname: Ye
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Kai-Juan
authors.initials: KJ
authors.lastname: Wang
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Zhang
mesh_terms: D000912:Antibodies, Neoplasm / Q000097:blood / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D014408:Biomarkers, Tumor; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000276:immunology*; D012680:Sensitivity and Specificity
chemical_list: D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D001323:Autoantibodies; D014408:Biomarkers, Tumor
keywords: autoantibody; biomarker; cancer screening; early diagnosis; ovarian cancer; tumor-associated antigen