title: Fat/carbohydrate ratio but not energy density determines snack food intake and activates brain reward areas.
abstract: The snack food potato chips induces food intake in ad libitum fed rats, which is associated with modulation of the brain reward system and other circuits. Here, we show that food intake in satiated rats is triggered by an optimal fat/carbohydrate ratio. Like potato chips, an isocaloric fat/carbohydrate mixture influenced whole brain activity pattern of rats, affecting circuits related e.g. to reward/addiction, but the number of modulated areas and the extent of modulation was lower compared to the snack food itself.
authors.affiliation: Food Chemistry Unit, Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Hoch
authors.affiliation: Institute of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
authors.forename: Silke
authors.initials: S
authors.lastname: Kreitz
authors.affiliation: 1] Pattern Recognition Lab, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany [2] School of Advanced Optical Technologies (SAOT), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
authors.forename: Simone
authors.initials: S
authors.lastname: Gaffling
authors.affiliation: Food Chemistry Unit, Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
authors.forename: Monika
authors.initials: M
authors.lastname: Pischetsrieder
authors.affiliation: Institute of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hess
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000503:physiopathology; D001921:Brain / Q000378:metabolism; D058256:Brain Waves / Q000502:physiology; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D004435:Eating / Q000502:physiology; D002149:Energy Intake / Q000502:physiology*; D005518:Food Preferences / Q000502:physiology*; D006963:Hyperphagia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012201:Reward; D062410:Snacks
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats