title: Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity.
abstract: Some neurotrophic factors, which are potent regulators of neuronal development and function, have recently been implicated in the control of energy balance by increasing energy expenditure. We previously identified neudesin as a novel neurotrophic factor with potential roles in the central nervous system. Although neudesin is also expressed in various peripheral tissues including adipose tissue, its physiological roles have not yet been elucidated. We found that neudesin knockout (KO) mice were resistant to high-fat diet-induced obesity and obesity-related metabolic dysfunctions. neudesin KO mice exhibited increased energy expenditure due to increased sympathetic activity, which resulted in increased heat production and fatty acid oxidation in brown adipose tissue and enhanced lipolysis in white adipose tissue. Thus, neudesin, which may be a negative regulator of sympathetic activity, could represent a novel regulator of the development of obesity and obesity-related metabolic dysfunctions.
authors.affiliation: Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Ohta
authors.affiliation: 1] Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan [2] Department of Microbial Chemistry, Kobe Pharmaceutical University, Kobe, Japan.
authors.forename: Morichika
authors.initials: M
authors.lastname: Konishi
authors.affiliation: Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kobayashi
authors.affiliation: Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan.
authors.forename: Atsuki
authors.initials: A
authors.lastname: Kashio
authors.affiliation: Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Mochiyama
authors.affiliation: Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agricultures, Kyoto University, Kyoto, Japan.
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Matsumura
authors.affiliation: Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agricultures, Kyoto University, Kyoto, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agricultures, Kyoto University, Kyoto, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Fushiki
authors.affiliation: Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Kazuwa
authors.initials: K
authors.lastname: Nakao
authors.affiliation: 1] Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan [2] Department of Pharmacogenomics, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kimura
authors.affiliation: Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Itoh
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism / Q000473:pathology; D052436:Adipose Tissue, White / Q000378:metabolism / Q000473:pathology; D000818:Animals; D059305:Diet, High-Fat; D004734:Energy Metabolism; D005247:Feeding Behavior; D005260:Female; D017353:Gene Deletion; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009414:Nerve Growth Factors / Q000172:deficiency / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000378:metabolism*; D009765:Obesity / Q000517:prevention & control*; D009929:Organ Size; D016716:PC12 Cells; D051381:Rats; D013564:Sympathetic Nervous System / Q000378:metabolism*
chemical_list: D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; C500817:neudesin protein, mouse