title: DNA duplex stability of the thio-iso-guanine•methyl-iso-Cytosine base pair.
abstract: We report the synthesis, incorporation into oligonucleotides, and base-pairing properties of the 2-thio-variant of iso-guanine. Iso-guanine is the purine component of a nonstandard base pair with 5-methyl-iso-cytosine. The 2-thio-iso-guanine • 5-methyl-iso-cytosine base pair is found to have similar stability to an adenine • thymine pair.
authors.affiliation: a Department of Chemistry , University of California , Riverside , Riverside , California.
authors.forename: Dongkye
authors.initials: D
authors.lastname: Lee
authors.forename: Christopher
authors.initials: C
authors.lastname: Switzer
mesh_terms: D044503:5-Methylcytosine / Q000031:analogs & derivatives* / Q000737:chemistry; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry*; D006147:Guanine / Q000737:chemistry*
chemical_list: C412877:5-methyl isocytosine; D006147:Guanine; D044503:5-Methylcytosine; D004247:DNA; C008183:isoguanine
keywords: DNA; origins of life; synthetic biology