title: Tumor-expressed IL-17D recruits NK cells to reject tumors.
abstract: Antitumor immunity suppresses tumorigenesis, but we do not understand how transformed cells initiate those immune responses that are essential for effective tumor immunosurveillance. Using the 3-MCA fibrosarcoma model, we identified IL-17D as a tumor-expressed cytokine that recruits natural killer cells, leading to the polarization of M1 macrophages and tumor rejection.
authors.affiliation: Department of Pathology; University of California ; San Diego, CA USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Saddawi-Konefka
authors.affiliation: Immunology Program; Memorial Sloan-Kettering Cancer Center ; New York, NY USA.
authors.forename: Timothy
authors.initials: T
authors.lastname: O'Sullivan
authors.affiliation: Department of Pathology; University of California ; San Diego, CA USA.
authors.forename: Emilie T
authors.initials: ET
authors.lastname: Gross
authors.affiliation: Department of Pathology; University of California ; San Diego, CA USA.
authors.forename: Allen
authors.initials: A
authors.lastname: Washington
authors.affiliation: Department of Pathology; University of California ; San Diego, CA USA.
authors.forename: Jack D
authors.initials: JD
authors.lastname: Bui
keywords: antitumor immunity; innate immunity; interleukin 17D; natural killer cells; tumor rejection