title: Use of 18F-fluoride positron emission tomography as a predictor of the hip osteoarthritis progression.
abstract: OBJECTIVE
  The prediction of hip osteoarthritis (OA) progression is still a difficult issue. We have adopted (18)F-fluoride positron emission tomography (PET) for the evaluation of hip osteoarthritis, and investigated the prediction utility of (18)F-fluoride PET for both pain worsening and OA progression using a logistic regression model.
  
  
  METHODS
  A total of 57 hip joints were analyzed for progression risk factors for pain worsening and minimum joint space (MJS) narrowing by logistic regression analysis. Sex, age, BMI, existence of pain, the PET maximum standardized uptake value (SUV(max)), Kellgren and Lawrence grade, MJS, and follow-up period were used as explanatory variables. Receiver operating characteristic analysis was performed to calculate the cutoff value of the SUV(max).
  
  
  RESULTS
  Multivariate logistic regression analysis revealed significant differences only in the SUV(max) values for pain worsening and MJS narrowing. The odds ratio of the SUV(max) for pain worsening was 1.89, and for MJS narrowing it was 11.02. The SUV(max) cutoff value was 7.2 (sensitivity: 1.00, specificity: 0.84) for pain worsening and 6.4 (sensitivity: 0.92, specificity: 0.83) for MJS narrowing.
  
  
  CONCLUSIONS
  Our results indicate that the PET SUV(max) is a best predictor of pain worsening and MJS narrowing. This imaging modality has a great potential for the prediction of OA progression.
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Kobayashi
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inaba
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Yukizawa
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ike
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: So
authors.initials: S
authors.lastname: Kubota
authors.affiliation: b Department of Radiology , Yokohama City University , Yokohama , Japan.
authors.forename: Tomio
authors.initials: T
authors.lastname: Inoue
authors.affiliation: a Department of Orthopaedic Surgery , Yokohama City University , Yokohama , Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Saito
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D006621:Hip Joint / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D012307:Risk Factors; D012680:Sensitivity and Specificity
keywords: 18F-fluoride positron emission tomography; Hip osteoarthritis; Prediction; Progression