title: Effects of analgesia methods on serum IL-6 and IL-10 levels after cesarean delivery.
abstract: This study aimed to discuss the effects of 3 different analgesia methods on serum IL-6 and IL-10 in patients after cesarean delivery. Thirty full-term women, who underwent cesarean delivery, were randomly assigned to 3 analgesia groups (10 cases each) as follows: intramuscular injection of 100 mg pethidine (NC group), patient controlled epidural analgesia (PCEA) of 5 mg morphine plus 150 mg ropivacaine (MR group), and patient controlled intravenous analgesia (PCIA) of 150 mg sufentanil plus 5 mg droperidol (SF group). An electronic analgesia pump was available in all 3 groups. At 4, 12, 24, and 48 h after surgery, visual analogue scale (VAS) pain scores were evaluated, IL-6 and IL-10 serum levels were measured, and adverse reactions were documented. The MR and SF groups responded well to analgesia. VAS scores at 12 and 24 h in these 2 groups were significantly lower than those in the NC group (P < 0.05). IL-6 and IL-10 levels were elevated to varying degrees postoperatively in all 3 groups. In the MR and SF groups, no significant difference occurred at each time point (P > 0.05), but compared with the NC group, significant differences were observed at 12 and 24 h (P < 0.05). Both PCIA and PCEA produced good analgesic effect, decreased postoperative level of serum IL-6, promoted release of anti-inflammatory factor IL-10, maintained balance in postoperative serum IL-6 level, and reduced the postoperative inflammatory response. Adverse reactions were significantly higher with epidural morphine than with intravenous sufentanil.
authors.affiliation: Anesthesia Department, No. 1 People's Hospital of Shunde, Foshan, Guangdong Province, China.
authors.forename: Z-M
authors.initials: ZM
authors.lastname: Xing
authors.affiliation: Anesthesia Department, No. 1 People's Hospital of Shunde, Foshan, Guangdong Province, China zhangzhongqi_l@163.com.
authors.forename: Z-Q
authors.initials: ZQ
authors.lastname: Zhang
authors.affiliation: Anesthesia Department, No. 1 People's Hospital of Shunde, Foshan, Guangdong Province, China.
authors.forename: W-S
authors.initials: WS
authors.lastname: Zhang
authors.affiliation: Anesthesia Department, No. 1 People's Hospital of Shunde, Foshan, Guangdong Province, China.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Liu
mesh_terms: D000698:Analgesia / Q000009:adverse effects / Q000379:methods*; D002585:Cesarean Section; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D011247:Pregnancy
chemical_list: D015850:Interleukin-6; D016753:Interleukin-10