title: [Features of coagulative blood potential disorder in acute constitutional inflammatory response of septic tubo-ovarian formations].
abstract: BACKGROUND
  There are no any systemized studies of relationship between the coagulative haemostasis' disorders and metabolic and cytokine status in patients with septic tuboovarial formations.
  
  
  OBJECTIVE
  The aim of the present work was to study the mechanisms of blood coagulation disorders and their relationships with changes of cytokine status and acute phase of inflammatory response in septic tubo-ovarian formations in women.
  
  
  METHODS
  32 patients with purulent tubovarial formations and 30 healthy women were examined.
  
  
  RESULTS
  Shortening of activated partial thromboplastin, prothrombin and thrombin clotting time, increasing the duration of XIIa-kallikrehin-dependent fibrinolysis, as well as the elevation of paracoagulation products in blood plasma were observed. IL-1β (p =0.000023), TNF-α (p <0.001), C-reactive protein (p <0.001), haptoglobin (p <0.001) and fibrinogen (p <0.001) levels were higher in peripheral blood of patients in comparison with healthy women. Accumulation of lipid hydroperoxides (p <0. 001) and malonic dialdehyde (p <0.001) occurred in the blood plasma of patients. Serum albumin (p <0.001) and transferring (p <0.001) levels were lesser in patients with purulent tubo ovarial formations in comparison with healthy women.
  
  
  CONCLUSIONS
  The obtained results showing an initiating role of cytokine and oxidative metabolic status changes in blood coagulation potential's and fibrinolysis activity's disorders developing. This biochemical signs may be used as objective criteria which may serve to determine the risk of thrombosis in case of acute inflammatory response in women with purulent inflammation.
authors.forename: G A
authors.initials: GA
authors.lastname: Afanasyeva
authors.forename: A N
authors.initials: AN
authors.lastname: Simonova
mesh_terms: D000328:Adult; D001777:Blood Coagulation; D016207:Cytokines / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D011446:Prospective Studies; D060737:Reproductive Tract Infections / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D013492:Suppuration / Q000378:metabolism / Q000503:physiopathology; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000378:metabolism; D013925:Thromboplastin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood / Q000209:etiology
chemical_list: D016207:Cytokines; D005340:Fibrinogen; D013925:Thromboplastin