title: Rapid onset of syndrome of inappropriate antidiuretic hormone secretion induced by duloxetine in an elderly type 2 diabetic patient with painful diabetic neuropathy.
abstract: Diabetic neuropathy is the most common diabetic complication. Duloxetine, a serotonin noradrenaline reuptake inhibitor (SNRI), is widely used for the treatment of diabetic painful neuropathy (DPN) because of the efficacy and safety profile. Syndrome of inappropriate antidiuretic hormone secretion, which is strongly associated duloxetine, is a rare but occasionally life-threatening adverse effect. Here, we report a case of syndrome of inappropriate antidiuretic hormone secretion that rapidly developed after starting duloxetine in an elderly Japanese female type 2 diabetes mellitus patient. Furthermore, we discuss the possible relationship between the onset of syndrome of inappropriate antidiuretic hormone secretion and the gene polymorphism of cytochrome P450 isoform 1A2 and 2D6, both of which are responsible for duloxetine metabolism.
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School Kurashiki, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kamei
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School Kurashiki, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kaneto
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School Kurashiki, Japan.
authors.forename: Akihito
authors.initials: A
authors.lastname: Tanabe
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School Kurashiki, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Irie
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School Kurashiki, Japan.
authors.forename: Yurie
authors.initials: Y
authors.lastname: Hirata
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School Kurashiki, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Shimoda
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School Kurashiki, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kohara
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School Kurashiki, Japan.
authors.forename: Tomoatsu
authors.initials: T
authors.lastname: Mune
authors.affiliation: Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School Kurashiki, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Kaku
keywords: Cytochrome P450; Duloxetine; Syndrome of inappropriate antidiuretic hormone secretion