title: Connectivity reveals relationship of brain areas for reward-guided learning and decision making in human and monkey frontal cortex.
abstract: Reward-guided decision-making depends on a network of brain regions. Among these are the orbitofrontal and the anterior cingulate cortex. However, it is difficult to ascertain if these areas constitute anatomical and functional unities, and how these areas correspond between monkeys and humans. To address these questions we looked at connectivity profiles of these areas using resting-state functional MRI in 38 humans and 25 macaque monkeys. We sought brain regions in the macaque that resembled 10 human areas identified with decision making and brain regions in the human that resembled six macaque areas identified with decision making. We also used diffusion-weighted MRI to delineate key human orbital and medial frontal brain regions. We identified 21 different regions, many of which could be linked to particular aspects of reward-guided learning, valuation, and decision making, and in many cases we identified areas in the macaque with similar coupling profiles.
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom and franz-xaver.neubert@psy.ox.ac.uk.
authors.forename: Franz-Xaver
authors.initials: FX
authors.lastname: Neubert
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom and Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom; and Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EZ Nijmegen, The Netherlands.
authors.forename: Rogier B
authors.initials: RB
authors.lastname: Mars
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom and.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Sallet
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom and Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom; and.
authors.forename: Matthew F S
authors.initials: MF
authors.lastname: Rushworth
mesh_terms: D000818:Animals; D063132:Connectome / Q000379:methods; D003657:Decision Making / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D008251:Macaca / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D012201:Reward; D013045:Species Specificity
keywords: anterior cingulate cortex; comparative anatomy; decision making; orbitofrontal cortex; resting state functional connectivity