title: Non-extracorporeal circulation for coronary artery bypass graft surgery is more beneficial than extracorporeal circulation.
abstract: OBJECTIVE
  The objective of this study was to compare coronary artery bypass graft (CABG) surgery with non-extracorporeal vs. extracorporeal circulation. The study outcomes included operative time, number of graft vessels, pulmonary infection rates, and systemic inflammatory markers.
  
  
  METHODS
  96 patients received selective CABG, either with non-extracorporeal (study group; n = 48) or extracorporeal circulation (control group; n = 48). Operative time, pulmonary infection rates, and blood levels of inflammatory markers TNF-α, IL-6, and IL-8 before and 4, 24, and 48 hours after the surgery were quantified. Graft vessels were quantified using computed tomography.
  
  
  RESULTS
  Operative time was significantly shorter in study group (4.58 ± 0.91 vs. 5.36 ± 1.12 hours in control group; p < 0.05). The number of graft vessels and pulmonary infection rates were comparable between both techniques. However, systemic inflammatory markers were significantly (p < 0.05) lower in study group at 4 and, partly, 24 hours after the surgery.
  
  
  CONCLUSIONS
  Extracorporeal circulation prolongs operation and can aggravate systemic inflammatory response. Therefore, CABG with non-extracorporeal circulation offers more beneficial outcomes.
authors.affiliation: Intensive Care Unit, The People's Hospital of Laiwu City, Laiwu, Shandong Province, China. drweiguangchen@163.com.
authors.forename: F-Y
authors.initials: FY
authors.lastname: Yang
authors.forename: Y-Z
authors.initials: YZ
authors.lastname: Bao
authors.forename: F-S
authors.initials: FS
authors.lastname: Liu
authors.forename: Y-C
authors.initials: YC
authors.lastname: Zhu
authors.forename: J
authors.initials: J
authors.lastname: Zheng
authors.forename: J-H
authors.initials: JH
authors.lastname: Zhang
authors.forename: X-F
authors.initials: XF
authors.lastname: Zheng
authors.forename: G-C
authors.initials: GC
authors.lastname: Wei
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods*; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha