title: Theta Burst Firing Recruits BDNF Release and Signaling in Postsynaptic CA1 Neurons in Spike-Timing-Dependent LTP.
abstract: Timing-dependent LTP (t-LTP) is a physiologically relevant type of synaptic plasticity that results from repeated sequential firing of action potentials (APs) in pre- and postsynaptic neurons. t-LTP can be observed in vivo and is proposed to be a cellular correlate of memory formation. While brain-derived neurotrophic factor (BDNF) is essential to high-frequency stimulation-induced LTP in many brain areas, the role of BDNF in t-LTP is largely unknown. Here, we demonstrate a striking change in the expression mechanism of t-LTP in CA1 of the hippocampus following two distinct modes of synaptic activation. Single postsynaptic APs paired with presynaptic stimulation activated a BDNF-independent canonical t-LTP. In contrast, a theta burst of postsynaptic APs preceded by presynaptic stimulation elicited BDNF-dependent postsynaptic t-LTP that relied on postsynaptic BDNF secretion. This suggests that BDNF release during burst-like patterns of activity typically observed in vivo may play a crucial role during memory formation.
authors.affiliation: Institut für Physiologie, Otto-von-Guericke-Universität, Medizinische Fakultät, Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address: elke.edelmann@med.ovgu.de.
authors.forename: Elke
authors.initials: E
authors.lastname: Edelmann
authors.affiliation: Institut für Physiologie, Otto-von-Guericke-Universität, Medizinische Fakultät, Leipziger Str. 44, 39120 Magdeburg, Germany.
authors.forename: Efrain
authors.initials: E
authors.lastname: Cepeda-Prado
authors.affiliation: Institut für Physiologie, Otto-von-Guericke-Universität, Medizinische Fakultät, Leipziger Str. 44, 39120 Magdeburg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Franck
authors.affiliation: Institut für Physiologie, Otto-von-Guericke-Universität, Medizinische Fakultät, Leipziger Str. 44, 39120 Magdeburg, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Lichtenecker
authors.affiliation: Institut für Physiologie, Otto-von-Guericke-Universität, Medizinische Fakultät, Leipziger Str. 44, 39120 Magdeburg, Germany; Center for Behavioral Brain Sciences, Otto-von-Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Brigadski
authors.affiliation: Institut für Physiologie, Otto-von-Guericke-Universität, Medizinische Fakultät, Leipziger Str. 44, 39120 Magdeburg, Germany; Center for Behavioral Brain Sciences, Otto-von-Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany. Electronic address: lessmann@med.ovgu.de.
authors.forename: Volkmar
authors.initials: V
authors.lastname: Leßmann
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D056547:CA1 Region, Hippocampal / Q000378:metabolism*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D055366:Synaptic Potentials / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor