title: Glomerular hyperfiltration in hypogonadotropic hypogonadic patients: Overlooking a cache?
abstract: OBJECTIVE
  To investigate renal function in idiopathic hypogonadotropic hypogonadic (IHH) patients by measuring glomerular filtration rate (GFR) using modification of diet in renal disease formula, and determine whether there is any relationship between GFR and testosterone levels.
  
  
  METHODS
  Thirty-three patients with IHH and 37 healthy control subjects participated in this study.
  
  
  RESULTS
  The IHH group showed statistically significant higher GFR and proteinuria with respect to the control group (163.1 ± 46.9 to 117.9 ± 30.5 mL/min, p < 0.001; 0.2 ± 0.1 to 0.08 ± 0.02 mg/dL, p = 0.041, respectively). Uric acid and creatinine levels were statistically lower than in the control group (4.6 ± 0.5-3.6 ± 0.9 mg/dL, p = 0.02; 0.7 ± 0.2 to 0.9 ± 0.2 mg/dL, p < 0.001, respectively). Hyperfiltration positively correlated with IHH in multivariate linear regression analyses (β = 0.591, p < 0.001). In addition, in the IHH group, we found that the GFR increased independently of body mass index and age.
  
  
  CONCLUSIONS
  Our study confirms that low testosterone in IHH patients is associated with glomerular hyperfiltration. Patients with IHH should be carefully monitored with respect to their GFR.
authors.affiliation: Department of Urology, Mustafa Kemal University, Hatay, Turkey, keremgozukara@yahoo.com.
authors.forename: Kerem Han
authors.initials: KH
authors.lastname: Gözükara
authors.forename: Abdulmuttalip
authors.initials: A
authors.lastname: Arslan
authors.forename: Sadık
authors.initials: S
authors.lastname: Görür
authors.forename: Mehmet Murat
authors.initials: MM
authors.lastname: Rifaioğlu
authors.forename: Ayşe
authors.initials: A
authors.lastname: Çarlıoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications; D008297:Male; D011379:Prognosis; D011507:Proteinuria / Q000175:diagnosis / Q000209:etiology; D051437:Renal Insufficiency / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D012307:Risk Factors; D013223:Statistics as Topic; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone; D003404:Creatinine