title: Theoretical study of microbubble dynamics in sonoporation.
abstract: Sonoporation is a promising technology for promoting the transfer of drug or gene into cells using ultrasound-mediated microbubbles that transiently break up the cell membrane. In this article, a model is established to analyze the dynamics of ultrasound-mediated microbubble near the cell membrane, which may be especially useful for understanding the mechanisms of sonoporation. In the model, the velocity potential of fluid on the microbubble surface and on the cell membrane is obtained by the unsteady Bernoulli equations, and it is solved by using the boundary integral equations. By numerically analyzing the model, the typical microbubble dynamics near the cell membrane are enumerated, which may be mainly governed by mechanical index. The model also established the connections among the parameters of ultrasound exposure, microbubble characteristics, and cell membrane properties in sonoporation.
authors.affiliation: Biomedical Engineering Department, Shenzhen Polytechnic, Shenzhen 518055, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
authors.affiliation: Shenzhen Institute for Drug Control, Shenzhen 518056, China.
authors.forename: Zhongshi
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Shenzhen Institute for Drug Control, Shenzhen 518056, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Dalong
authors.initials: D
authors.lastname: Liu
authors.affiliation: National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Department of Biomedical Engineering, School of Medicine, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen University, Shenzhen 518060, China. Electronic address: shenyy@szu.edu.cn.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Shen
mesh_terms: D002463:Cell Membrane Permeability / Q000502:physiology*; D045423:Microbubbles; D008962:Models, Theoretical; D013010:Sonication
keywords: Boundary element method; Cell membrane; Microbubble; Numerical model; Sonoporation