title: Serum Uric Acid and Prehypertension Among Adults Free of Cardiovascular Diseases and Diabetes: Baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
abstract: The association between serum uric acid (SUA) and prehypertension was evaluated in a racially admixed sample of civil servants aged 35 to 74 years, enrolled (2008-2010) in the Brazilian Longitudinal Study of Health (ELSA-Brasil). Of the 15 105 patients who enrolled in the study, we analyzed 3412 after excluding those who reported previous cardiovascular diseases, diabetes, or hypertension; were heavy drinkers; or had a body mass index (BMI) ≥ 35 kg/m(2). Among the men, logistic regression, adjusted for age, race, income, birth weight, salt intake, insulin resistance, BMI, and renal function revealed odds ratios (ORs) and 95% confidence intervals (CIs) of prehypertension from the bottom quartile (referent) to the top quartile of SUA levels as follows: 0.84 (95% CI, 0.61-1.38), 0.97 (0.71-1.34) and 1.44 (1.04-2.0; P for trend .01). Analyzing for 1-standard deviation of change in SUA, the ORs were 1.19 (1.06-1.32). This association persisted in the subgroup analysis consisting of patients who were white, overweight, with a high salt intake but with normal renal function, and without metabolic syndrome. No association was found among women. In conclusion, SUA levels were associated with prehypertension among men.
authors.affiliation: Hospital Universitario, Center for Clinical and Epidemiologic Research of the University of São Paulo, Sao Paulo, Brazil Department of Medicine, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil palotufo@usp.br.
authors.forename: Paulo A
authors.initials: PA
authors.lastname: Lotufo
authors.affiliation: Hospital Universitario, Center for Clinical and Epidemiologic Research of the University of São Paulo, Sao Paulo, Brazil School of Medicine, Pontifícia Universidade Católica Paraná, Curitiba, Brazil.
authors.forename: Cristina P
authors.initials: CP
authors.lastname: Baena
authors.affiliation: Hospital Universitario, Center for Clinical and Epidemiologic Research of the University of São Paulo, Sao Paulo, Brazil Department of Medicine, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Itamar S
authors.initials: IS
authors.lastname: Santos
authors.affiliation: Hospital Universitario, Center for Clinical and Epidemiologic Research of the University of São Paulo, Sao Paulo, Brazil Department of Medicine, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
authors.forename: Isabela M
authors.initials: IM
authors.lastname: Bensenor
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001938:Brazil / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006306:Health Surveys; D006801:Humans; D033461:Hyperuricemia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D008019:Life Style; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D058246:Prehypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors; D012737:Sex Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid
keywords: birth weight; insulin resistance; obesity; preeclampsia; salt intake; subclinical atherosclerosis; uricase