title: Docosahexaenoic Acid alleviates atopic dermatitis in mice by generating T regulatory cells and m2 macrophages.
abstract: Han et al. (this issue) describe a novel mechanism by which docosahexaenoic acid (DHA) may suppress atopic dermatitis symptoms in mice. They find that DHA induces FoxP3 T regulatory cells in vivo, M2 macrophages drive transforming growth factor-β and IL-10 conversion of CD4 T cells to CD4 FoxP3 T regulatory cells in vitro, and DHA-treated M2 macrophages suppress atopic dermatitis in mice.
authors.affiliation: Brigham and Women's Hospital, Harvard Skin Disease Research Center/Department of Dermatology, Boston, Massachusetts, USA.
authors.forename: Karyn A
authors.initials: KA
authors.lastname: Haitz
authors.affiliation: Brigham and Women's Hospital, Harvard Skin Disease Research Center/Department of Dermatology, Boston, Massachusetts, USA. Electronic address: nanandasabapathy@partners.org.
authors.forename: Niroshana
authors.initials: N
authors.lastname: Anandasabapathy
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology*; D004281:Docosahexaenoic Acids / Q000737:chemistry*; D016753:Interleukin-10 / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D053773:Transforming Growth Factor beta1 / Q000276:immunology*
chemical_list: D053773:Transforming Growth Factor beta1; D016753:Interleukin-10; D004281:Docosahexaenoic Acids