title: Copper-catalyzed intermolecular asymmetric propargylic dearomatization of indoles.
abstract: The first copper-catalyzed intermolecular dearomatization of indoles by an asymmetric propargylic substitution reaction was developed. This method provides a highly efficient synthesis of versatile furoindoline and pyrroloindoline derivatives containing a quaternary carbon stereogenic center and a terminal alkyne moiety with up to 86 % yield and 98 % ee.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn.
authors.forename: Wen
authors.initials: W
authors.lastname: Shao
authors.affiliation: Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education & Xinjiang Uygur Autonomous Region, Physics and Chemistry Detecting Centre, Xinjiang University, Urumqi 830046 (China).
authors.forename: He
authors.initials: H
authors.lastname: Li
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn.
authors.forename: Chuan
authors.initials: C
authors.lastname: Liu
authors.affiliation: Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education & Xinjiang Uygur Autonomous Region, Physics and Chemistry Detecting Centre, Xinjiang University, Urumqi 830046 (China).
authors.forename: Chen-Jiang
authors.initials: CJ
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 (China) http://shuliyou.sioc.ac.cn. slyou@sioc.ac.cn.|Collaborative Innovation Centre of Chemical Science and Engineering, Tianjin 300072 (China). slyou@sioc.ac.cn.
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D003300:Copper
keywords: asymmetric catalysis; copper; dearomatization; heterocycles; synthetic methods