title: Investigation of cyano-bridged coordination nanoparticles Gd(3+)/[Fe(CN)6](3-)/D-mannitol as T1-weighted MRI contrast agents.
abstract: Cyano-bridged Gd(3+)/[Fe(CN)6](3-) coordination polymer nanoparticles of 3-4 nm stabilized with D-mannitol presenting a high r1 relaxivity value of 11.4 mM(-1) s(-1) were investigated in vivo as contrast agents (CA) for Magnetic Resonance Imaging (MRI). They allow an increase of the MR image contrast and can act as an efficient intravascular T1 CA with a relatively long blood-circulation lifetime (60 min) without specific toxicity.
authors.affiliation: Institut Charles Gerhardt Montpellier (ICGM), UMR 5253, Université de Montpellier, Place Eugène Bataillon, 34095 Montpellier Cedex 05, France. joulia.larionova@um2.fr.
authors.forename: M
authors.initials: M
authors.lastname: Perrier
authors.forename: A
authors.initials: A
authors.lastname: Gallud
authors.forename: A
authors.initials: A
authors.lastname: Ayadi
authors.forename: S
authors.initials: S
authors.lastname: Kennouche
authors.forename: C
authors.initials: C
authors.lastname: Porredon
authors.forename: M
authors.initials: M
authors.lastname: Gary-Bobo
authors.forename: J
authors.initials: J
authors.lastname: Larionova
authors.forename: Ch
authors.initials: Ch
authors.lastname: Goze-Bac
authors.forename: M
authors.initials: M
authors.lastname: Zanca
authors.forename: M
authors.initials: M
authors.lastname: Garcia
authors.forename: I
authors.initials: I
authors.lastname: Basile
authors.forename: J
authors.initials: J
authors.lastname: Long
authors.forename: J
authors.initials: J
authors.lastname: de Lapuente
authors.forename: M
authors.initials: M
authors.lastname: Borras
authors.forename: Y
authors.initials: Y
authors.lastname: Guari
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D003486:Cyanides / Q000737:chemistry / Q000494:pharmacology; D005682:Gadolinium / Q000737:chemistry / Q000494:pharmacology; D007501:Iron / Q000737:chemistry / Q000494:pharmacology; D008279:Magnetic Resonance Imaging; D008353:Mannitol / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D051379:Mice
chemical_list: D003287:Contrast Media; D003486:Cyanides; D008353:Mannitol; D005682:Gadolinium; D007501:Iron