title: An update on Anti-inflammatory Compounds: A Review.
abstract: Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process. Also, it has been reported to be associated with the onset of various cancers. An effective anti-inflammatory drug should be able to inhibit the development of inflammation without interfering in normal homeostasis. Current approaches to overcome the inflammation include the use of immune selective anti-inflammatory derivatives, selective glucocorticoid receptor agonist, resolvins and protectins and TNF inhibitors. A number of herbal drugs have been identified in the past that can target inflammatory cytokines. This review mainly focuses on the newer molecules to combat the inflammation and also emphasise on various studies carried out in the past. Thus, the high prevalence of inflammation obliges the development of new drugs; therefore, a safe and efficient drug molecule to confer protection against inflammation is urgently needed.
authors.affiliation: Guru Gobind Singh College of Pharmacy, Near Guru Nanak Khalsa College, City Center Road, Yamuna Nagar-135001, Haryana, India. ashwani1683@gmail.com.
authors.forename: Ashwani Kumar
authors.initials: AK
authors.lastname: Dhingra
authors.forename: Bhawna
authors.initials: B
authors.lastname: Chopra
authors.forename: Rameshwar
authors.initials: R
authors.lastname: Dass
authors.forename: Sanjeev Kumar
authors.initials: SK
authors.lastname: Mittal
mesh_terms: D017305:Annexin A1 / Q000096:biosynthesis; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D015777:Eicosanoids / Q000096:biosynthesis; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D018836:Inflammation Mediators / Q000378:metabolism; D010146:Pain / Q000188:drug therapy; D010946:Plants, Medicinal; D011965:Receptors, Glucocorticoid / Q000819:agonists; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D017305:Annexin A1; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D015777:Eicosanoids; D005938:Glucocorticoids; D018836:Inflammation Mediators; D011965:Receptors, Glucocorticoid; D014409:Tumor Necrosis Factor-alpha; D015118:Eicosapentaenoic Acid