title: Interventions for migraine prophylaxis: protocol of an umbrella systematic review and network meta-analysis.
abstract: BACKGROUND
  Multiple interventions are effective for migraine prophylaxis. However, the comparative effectiveness of these interventions is still not clear. Therefore, the aim of this study is to summarise the direct and indirect evidence for pharmacological and non-pharmacological interventions to prevent migraine attack.
  
  
  METHODS
  We will perform an umbrella systematic review to identify eligible randomised controlled trials (RCTs) for the recommended interventions for migraine prophylaxis according to the guidelines. A comprehensive literature search will be conducted in MEDLINE, EMBASE and the Cochrane library for systematic reviews, which will be screened for RCTs. We will describe the general information of the RCTs for participants, interventions, outcome measurements, comparisons and the primary findings. Additionally, a network meta-analysis will be conducted to determine the comparative effectiveness of the treatments with a random-effects model. The absolute and relative effectiveness of the treatments will be provided. The heterogeneity and inconsistency between trials will be assessed by the I(2) statistical test and Cochrane's Q test. Risk of bias will be assessed and the overall strength of the evidence will be summarised.
  
  
  CONCLUSIONS
  The result of this network meta-analysis will provide direct and indirect evidence of treatments for migraine prophylaxis, and it may provide a ranking of the treatments for patients and clinicians to help them select the best option.
  
  
  BACKGROUND
  PROSPERO CRD42015015297.
authors.affiliation: Acupuncture & Tuina College/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Anorectal Department, The First Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Anorectal Department, The First Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
authors.forename: Dequan
authors.initials: D
authors.lastname: Huang
authors.affiliation: Acupuncture & Tuina College/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.affiliation: The Third Clinical College of Zhejiang Chinese Medical University, Hangzhou, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Chen
authors.affiliation: The Third Clinical College of Zhejiang Chinese Medical University, Hangzhou, China.
authors.forename: Jianqiao
authors.initials: J
authors.lastname: Fang
mesh_terms: D006801:Humans; D015670:Acupuncture Therapy; D000927:Anticonvulsants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001521:Behavior Therapy / Q000379:methods; D008881:Migraine Disorders / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D000078202:Systematic Reviews as Topic; D014815:Vitamins / Q000627:therapeutic use; D000071076:Network Meta-Analysis as Topic
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D014815:Vitamins
keywords: COMPLEMENTARY MEDICINE