title: OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis.
abstract: Significant advances have occurred in our understanding of the pathogenesis of knee osteoarthritis (OA) and some recent trials have demonstrated the potential for modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply knee imaging in knee OA trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for magnetic resonance imaging (MRI)); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance (QA)/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations.
authors.affiliation: Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, NSW, Australia; Rheumatology Department, Royal North Shore Hospital, University of Sydney, Sydney, NSW, Australia. Electronic address: David.Hunter@sydney.edu.au.
authors.forename: D J
authors.initials: DJ
authors.lastname: Hunter
authors.affiliation: Department of Medicine, Division of Rheumatology and Immunology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Altman
authors.affiliation: School of Public health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne 3004, Australia.
authors.forename: F
authors.initials: F
authors.lastname: Cicuttini
authors.affiliation: Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, Hospital do Coração (HCor) and Teleimagem, São Paulo, SP, Brazil.
authors.forename: M D
authors.initials: MD
authors.lastname: Crema
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Duryea
authors.affiliation: Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Eckstein
authors.affiliation: Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Guermazi
authors.affiliation: Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
authors.forename: R
authors.initials: R
authors.lastname: Kijowski
authors.affiliation: Department of Radiology and Biomedical Imaging, UCSF, San Francisco, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Link
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Martel-Pelletier
authors.affiliation: BioClinica, Newtown, PA, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Miller
authors.affiliation: Department of Radiology, Penn State University, Hershey, PA, USA; Department of Orthopaedic Surgery, Penn State University, Hershey, PA, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Mosher
authors.affiliation: Department of Radiology, The American British Cowdray Medical Center, Mexico City, Mexico.
authors.forename: R E
authors.initials: RE
authors.lastname: Ochoa-Albíztegui
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
authors.forename: J-P
authors.initials: JP
authors.lastname: Pelletier
authors.affiliation: Spire Sciences, Inc., Boca Raton, Florida, USA.
authors.forename: C
authors.initials: C
authors.lastname: Peterfy
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.
authors.forename: J-P
authors.initials: JP
authors.lastname: Raynauld
authors.affiliation: Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA; Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: F W
authors.initials: FW
authors.lastname: Roemer
authors.affiliation: Qmetrics Technologies, Rochester, NY, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Totterman
authors.affiliation: Department of Radiology, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Gold
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards*; D003952:Diagnostic Imaging / Q000592:standards*; D018450:Disease Progression; D006801:Humans; D020370:Osteoarthritis, Knee / Q000175:diagnosis*; D017410:Practice Guidelines as Topic
keywords: Clinical trial recommendations; Imaging; Knee osteoarthritis