title: Genetic polymorphism in extracellular regulators of Wnt signaling pathway.
abstract: The Wnt signaling pathway is mediated by a family of secreted glycoproteins through canonical and noncanonical mechanism. The signaling pathways are regulated by various modulators, which are classified into two classes on the basis of their interaction with either Wnt or its receptors. Secreted frizzled-related proteins (sFRPs) are the member of class that binds to Wnt protein and antagonizes Wnt signaling pathway. The other class consists of Dickkopf (DKK) proteins family that binds to Wnt receptor complex. The present review discusses the disease related association of various polymorphisms in Wnt signaling modulators. Furthermore, this review also highlights that some of the sFRPs and DKKs are unable to act as an antagonist for Wnt signaling pathway and thus their function needs to be explored more extensively.
authors.affiliation: Institute for Skeletal Aging & Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do 200-704, Republic of Korea ; Amity Institute of Nanotechnology, Amity University Uttar Pradesh, Noida, Uttar Pradesh 201313, India.
authors.forename: Garima
authors.identifier: 0000-0003-1763-0730
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Institute for Skeletal Aging & Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do 200-704, Republic of Korea.
authors.forename: Ashish Ranjan
authors.initials: AR
authors.lastname: Sharma
authors.affiliation: Institute for Skeletal Aging & Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do 200-704, Republic of Korea.
authors.forename: Eun-Min
authors.initials: EM
authors.lastname: Seo
authors.affiliation: Institute for Skeletal Aging & Orthopaedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do 200-704, Republic of Korea ; Adbiotech Co., Ltd., Chuncheon-si, Gangwon-do 200-880, Republic of Korea.
authors.forename: Ju-Suk
authors.initials: JS
authors.lastname: Nam
mesh_terms: D000818:Animals; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D060490:Receptors, Wnt / Q000235:genetics / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000502:physiology*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D060490:Receptors, Wnt