title: Hepatitis C treatment for patients post liver transplant.
abstract: OBJECTIVE
  To give a comprehensive update of the current hepatitis C (HCV) antiviral treatments in the liver transplant setting.
  
  
  RESULTS
  Hepatitis C treatment after liver transplantation with several interferon-free combinations has shown excellent efficacy and safety results, overwhelming interferon-based therapies in this setting. In posttransplant decompensated liver disease, however, efficacy of antiviral therapies seems to be lower, but viral eradication has been associated with an improvement of liver function and clinical status in most cases. Hence, antiviral treatment should be offered before advanced liver disease is reached, in order to prevent graft damage and guarantee the best efficacy rates of therapies.
  
  
  CONCLUSIONS
  New interferon-free combinations with potent direct antivirals cure hepatitis C in most of patients after liver transplantation. Hepatitis C after liver transplantation should be treated as early as possible and before advanced liver disease is established in the graft. In patients with graft cirrhosis, eradication of hepatitis C is associated with improved liver function.
authors.affiliation: Liver Unit, Hospital Clinic, IDIBAPS, CIBEREHD, University of Barcelona, Barcelona, Spain.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Mariño
authors.forename: Maria-Carlota
authors.initials: MC
authors.lastname: Londoño
authors.forename: Xavier
authors.initials: X
authors.lastname: Forns
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006526:Hepatitis C / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D008111:Liver Function Tests; D016031:Liver Transplantation
chemical_list: D000998:Antiviral Agents; D007372:Interferons