title: Promoting blood circulation for removing blood stasis therapy for acute intracerebral hemorrhage: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To conduct a systematic review and meta-analysis to assess the current evidence available regarding the promoting blood circulation and removing blood stasis (PBCRBS) therapy for Chinese patients with acute intracerebral hemorrhage (ICH).
  
  
  METHODS
  Six databases were searched from their inception to November 2013. The studies assessed in ≥ 4 domains with 'yes' were selected for detailed assessment and meta-analysis. The herbal compositions for PBCRBS therapy for acute ICH patients were also assessed.
  
  
  RESULTS
  From the 6 databases, 292 studies claimed randomized-controlled clinical trials (RCTs). Nine studies with 798 individuals were assessed in ≥ 4 domains with 'yes' by using the Cochrane RoB tool. Meta-analysis showed that PBCRBS monotherapy and adjuvant therapy for acute ICH could improve the neurological function deficit, reduce the volume of hematoma and perihematomal edema, and lower the mortality rate and dependency. Moreover, there were fewer adverse effects when compared with Western conventional medication controls. Xueshuantong Injection and Fufang Danshen Injection, Buyang Huanwu Decoction and Liangxue Tongyu formula, and three herbs (danshen root, sanqi and leech) were the most commonly used Chinese herbal patent injections, herbal prescriptions and single herbs, respectively.
  
  
  CONCLUSIONS
  Despite the apparently positive findings, it is premature to conclude that there is sufficient efficacy and safety of PBCRBS for ICH because of the high clinical heterogeneity of the included studies and small number of trials in the meta-analysis. Further large sample-sizes and rigorously designed RCTs are needed.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Hui-qin
authors.initials: HQ
authors.lastname: Li
authors.affiliation: Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Wei
authors.affiliation: Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Wan
authors.initials: W
authors.lastname: Xia
authors.affiliation: Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Ji-huang
authors.initials: JH
authors.lastname: Li
authors.affiliation: Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Ai-ju
authors.initials: AJ
authors.lastname: Liu
authors.affiliation: Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Su-bing
authors.initials: SB
authors.lastname: Yin
authors.affiliation: Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Song
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.
authors.forename: Guo-qing
authors.initials: GQ
authors.lastname: Zheng
authors.affiliation: China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Ji-ping
authors.initials: JP
authors.lastname: Fan
mesh_terms: D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D016009:Chi-Square Distribution; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D006406:Hematoma / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D016017:Odds Ratio; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal