title: Thymic low affinity/avidity interaction selects natural Th1 cells.
abstract: Identification of intrathymic eomesodermin(+) (Eomes(+)) CD4 T cells creates a novel idea that there is more than one way for the generation of innate CD4 T cells. Promyelocytic leukemia zinc finger protein(+) T cells and natural Th17 cells are known to be generated by sensing a high and persistent TCR strength, whereas this is not the case for Eomes(+) CD4 T cells. These cells go through low-level signal during the entire maturation pathway, which subsequently leads to induction of high susceptibility to cytokine IL-4. This event seems to be a major determinant for the generation of this type of cell. These T cells are functionally equivalent to Th1 cells that are present in the periphery, and this event takes place both in transgenic and in wild-type mice. There is additional evidence that this type of Eomes(+) innate CD4 T cell is also present in human cord blood.
authors.affiliation: Graduate School of Immunology, Seoul National University College of Medicine, Seoul 110-799, Korea;
authors.forename: Byung Hyun
authors.initials: BH
authors.lastname: Kang
authors.affiliation: Department of Pathology, Seoul National University College of Medicine, Seoul 110-799, Korea; Department of Pathology, Seoul National University Bundang Hospital, SungNam 463-707, Korea;
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Park
authors.affiliation: Graduate School of Immunology, Seoul National University College of Medicine, Seoul 110-799, Korea;
authors.forename: Hye In
authors.initials: HI
authors.lastname: Yum
authors.affiliation: Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea;
authors.forename: Seung Pyo
authors.initials: SP
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea; Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul 110-744, Korea;
authors.forename: Jin Kyun
authors.initials: JK
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea; Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, SungNam 463-707, Korea;
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Kang
authors.affiliation: Graduate School of Immunology, Seoul National University College of Medicine, Seoul 110-799, Korea; Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea;
authors.forename: Jae-Il
authors.initials: JI
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea; Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul 110-744, Korea;
authors.forename: Eun Bong
authors.initials: EB
authors.lastname: Lee
authors.affiliation: Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 110-799, Korea; Translational Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea; and.
authors.forename: Chung-Gyu
authors.initials: CG
authors.lastname: Park
authors.affiliation: Graduate School of Immunology, Seoul National University College of Medicine, Seoul 110-799, Korea; Department of Pathology, Seoul National University College of Medicine, Seoul 110-799, Korea; Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea; Department of Pathology, Seoul National University Hospital, Seoul 110-744, Korea pshoe@snu.ac.kr jungkc66@snu.ac.kr.
authors.forename: Kyeong Cheon
authors.initials: KC
authors.lastname: Jung
authors.affiliation: Graduate School of Immunology, Seoul National University College of Medicine, Seoul 110-799, Korea; Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea; pshoe@snu.ac.kr jungkc66@snu.ac.kr.
authors.forename: Seong Hoe
authors.initials: SH
authors.lastname: Park
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation; D060966:Clonal Selection, Antigen-Mediated; D005312:Fetal Blood / Q000166:cytology; D015870:Gene Expression; D000949:Histocompatibility Antigens Class II / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D015847:Interleukin-4 / Q000378:metabolism; D051741:Kruppel-Like Transcription Factors / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D000075722:Promyelocytic Leukemia Zinc Finger Protein; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism; D018417:Th1 Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D060168:Thymocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D013950:Thymus Gland / Q000276:immunology* / Q000378:metabolism*
chemical_list: C491198:Eomes protein, mouse; D000949:Histocompatibility Antigens Class II; D051741:Kruppel-Like Transcription Factors; D000075722:Promyelocytic Leukemia Zinc Finger Protein; D011948:Receptors, Antigen, T-Cell; D020825:T-Box Domain Proteins; C513267:Zbtb16 protein, mouse; D015847:Interleukin-4