title: A Fresh Look on T-Box Factor Action in Early Embryogenesis (T-Box Factors in Early Development).
abstract: T-Box transcription factors are expressed throughout the gestational period and coordinate a variety of embryonic events that enable proper development, from the first differentiation of embryonic and extraembryonic tissues until final organogenesis. Although the T-Box gene family comprises essential roles in early cellular differentiation, in adult tissues it has also been associated with cancer development. In spite of their common T-Box regulatory binding domain, T-Box family members utilize different cofactors and different spatiotemporal expression patterns to confer their specificity in diverse developmental processes. The earliest expression note of T-Box factors can be observed even before fertilization in primordial germ cells and just after zygotic gene activation (around the eight-cell blastomere stage). Thus, particularly the early stages of development are highly influenced by these key regulators in line with the notion that T-Box mutations lead to developmental disorders and even lethality. In this review, we summarize recently acquired findings on T-Box factors to provide a comprehensive overview on their role during early embryogenesis.
authors.affiliation: 1 Institute of Neuroanatomy, Eberhard Karls University Tübingen , Tübingen, Germany .
authors.forename: Maíra
authors.initials: M
authors.lastname: Bertolessi
authors.affiliation: 1 Institute of Neuroanatomy, Eberhard Karls University Tübingen , Tübingen, Germany .
authors.forename: Leonhard
authors.initials: L
authors.lastname: Linta
authors.affiliation: 2 Department of Internal Medicine 1, Ulm University Hospital , Ulm, Germany .
authors.forename: Thomas
authors.initials: T
authors.lastname: Seufferlein
authors.affiliation: 2 Department of Internal Medicine 1, Ulm University Hospital , Ulm, Germany .
authors.forename: Alexander
authors.initials: A
authors.lastname: Kleger
authors.affiliation: 1 Institute of Neuroanatomy, Eberhard Karls University Tübingen , Tübingen, Germany .
authors.forename: Stefan
authors.initials: S
authors.lastname: Liebau
mesh_terms: D000818:Animals; D047108:Embryonic Development / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D020825:T-Box Domain Proteins / Q000235:genetics* / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D020825:T-Box Domain Proteins