title: CuS@mSiO2-PEG core-shell nanoparticles as a NIR light responsive drug delivery nanoplatform for efficient chemo-photothermal therapy.
abstract: We report a facile and low-cost approach to design a difunctional nanoplatform (CuS@mSiO2-PEG) as a near-infrared (NIR) light responsive drug delivery system for efficient chemo-photothermal therapy. The nanoplatform demonstrated good biocompatibility and colloidal stability, as well as high loading capacity for the anticancer drug (26.5 wt% for doxorubicin (DOX)). The CuS nanocrystals (core) within these CuS@mSiO2-PEG core-shell nanoparticles can effectively absorb and convert NIR light to fatal heat under NIR light irradiation for photothermal therapy, and the release of DOX from the mesoporous silica (shell) can be triggered by pH and NIR light for chemotherapy. When the CuS@mSiO2-PEG/DOX nanocomposites were irradiated by 980 nm light, both chemotherapy and photothermal therapy were simultaneously driven, resulting in a synergistic effect for killing cancer cells. Importantly, compared with chemotherapy or photothermal treatment alone, the combined therapy significantly improved the therapeutic efficacy.
authors.affiliation: College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China.
authors.forename: Xijian
authors.initials: X
authors.lastname: Liu
authors.forename: Qilong
authors.initials: Q
authors.lastname: Ren
authors.forename: Fanfan
authors.initials: F
authors.lastname: Fu
authors.forename: Rujia
authors.initials: R
authors.lastname: Zou
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Guobing
authors.initials: G
authors.lastname: Xin
authors.forename: Zhiyin
authors.initials: Z
authors.lastname: Xiao
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Huang
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Junqing
authors.initials: J
authors.lastname: Hu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D003131:Combined Modality Therapy; D003300:Copper / Q000737:chemistry*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000528:radiation effects; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D003300:Copper; D004317:Doxorubicin; C017846:cupric sulfide