title: [Radiation therapy and redox imaging].
abstract: Radiation therapy kills cancer cells in part by flood of free radicals. Radiation ionizes and/or excites water molecules to create highly reactive species, i.e. free radicals and/or reactive oxygen species. Free radical chain reactions oxidize biologically important molecules and thereby disrupt their function. Tissue oxygen and/or redox status, which can influence the course of the free radical chain reaction, can affect the efficacy of radiation therapy. Prior observation of tissue oxygen and/or redox status is helpful for planning a safe and efficient course of radiation therapy. Magnetic resonance-based redox imaging techniques, which can estimate tissue redox status non-invasively, have been developed not only for diagnostic information but also for estimating the efficacy of treatment. Redox imaging is now spotlighted to achieve radiation theranostics.
authors.affiliation: Radio-Redox-Response Research Team, Advanced Particle Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences.
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D003287:Contrast Media; D005609:Free Radicals; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D057054:Molecular Imaging / Q000379:methods / Q000639:trends; D010084:Oxidation-Reduction; D011878:Radiotherapy; D017382:Reactive Oxygen Species; D000068936:Theranostic Nanomedicine; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D005609:Free Radicals; D017382:Reactive Oxygen Species