title: Catalytic Ortho-Acetoxylation of Masked Benzyl Alcohols via an Exo-Directing Mode.
abstract: A Pd-catalyzed ortho-acetoxylation of masked benzyl alcohols to synthesize various 2-hydroxyalkylphenol derivatives is reported. The 2,6-dimethoxyl benzaldoxime proved to be an efficient exo-type directing group for arene (sp(2)) C-H functionalization. Two strategies were demonstrated to remove the directing group through N-O and C-O bond cleavages. A high catalyst turnover (>1000) was obtained to illustrate the practicality of this method.
authors.affiliation: †Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Ren
authors.affiliation: ‡Department of Chemistry and Biochemistry, Southwestern University, Georgetown, Texas 78626, United States.
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Schulz
authors.affiliation: †Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
authors.forename: Guangbin
authors.initials: G
authors.lastname: Dong