title: The proportion of genes in a functional category is linked to mass-specific metabolic rate and lifespan.
abstract: Metabolic rate and lifespan are important biological parameters that are studied in a wide range of research fields. They are known to correlate with body mass, but their association with gene (protein) functions is poorly understood. In this study, we collected data on the metabolic rate and lifespan of various organisms and investigated the relationship of these parameters with their genomes. We showed that the proportion of genes in a functional category, but not genome size, was correlated with mass-specific metabolic rate and maximal lifespan. In particular, the proportion of genes in oxic reactions (which occur in the presence of oxygen) was significantly associated with these two biological parameters. Additionally, we found that temperature, taxonomy, and mode-of-life traits had little effect on the observed associations. Our findings emphasize the importance of considering the biological functions of genes when investigating the relationships between genome, metabolic rate, and lifespan. Moreover, this provides further insights into these relationships, and may be useful for estimating metabolic rate and lifespan in individuals and the ecosystem using a combination of body mass measurements and genomic data.
authors.affiliation: Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Fukuoka 820-8502, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takemoto
authors.affiliation: Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Iizuka, Fukuoka 820-8502, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kawakami
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D004734:Energy Metabolism / Q000235:genetics*; D016678:Genome / Q000502:physiology*; D006801:Humans; D008019:Life Style; D008136:Longevity / Q000235:genetics*; D010101:Oxygen Consumption / Q000235:genetics*; D020543:Proteome / Q000502:physiology*; D013045:Species Specificity
chemical_list: D020543:Proteome