title: The Effect of Coenzyme Q10 (Ubiquinone) on Random Pattern Skin Flap Survival in Rat Model.
abstract: BACKGROUND
  In this study, the effect of coenzyme Q10 (CQ10) on flap survival was investigated.
  
  
  METHODS
  Fifty Wistar Albino rats were divided into 5 groups. The survival rates of the skin flaps were assessed 10 days after complete elevation of the flaps. Regions of survival and necrosis were drawn on transparent acetate sheets and scanned into a computer. Tissue samples were assessed histopathologically after staining with hematoxylin-eosin, vascular endothelial growth factor staining and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-Biotin Nick End-labeling staining. To evaluate the antioxidant effect of CQ10; malondialdehyde, nitric oxide levels were measured.
  
  
  RESULTS
  Viable flaps area was found higher in groups 3 and 4 as compared to groups 1, 2, and 5. In terms of vascular proliferation, elevated angiogenesis was observed in pathological specimens of groups 3 and 4 as compared to groups 1, 2, and 5. Malondialdehyde levels in groups 3 and 4 were found to be significantly decreased as compared to groups 1, 2 and 5 (P < 0.05). Moreover, serum levels of CQ10 were found significantly increased in groups 3 and 4 (P < 0.05).
  
  
  CONCLUSIONS
  In conclusion, CQ10 significantly improves flap viability in rat model, and the highest levels of serum CQ10 can be obtained by oral administration.
authors.affiliation: From the *Private Gözde Hospital, İzmir; †Department of Plastic and Reconstructive Surgery, ‡Department of Physiology, Mustafa Kemal University, School of Medicine, Hatay; and §Department of Plastic and Reconstructive Surgery, Gaziantep University School of Medicine, Gaziantep, Turkey.
authors.forename: Asli
authors.initials: A
authors.lastname: Can
authors.forename: Metin
authors.initials: M
authors.lastname: Temel
authors.forename: Recep
authors.initials: R
authors.lastname: Dokuyucu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Mutaf
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D004334:Drug Administration Schedule; D007274:Injections, Intraperitoneal; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D019990:Perioperative Care / Q000379:methods; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013524:Surgical Flaps / Q000098:blood supply / Q000502:physiology*; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014451:Ubiquinone; D009569:Nitric Oxide; D008315:Malondialdehyde; C024989:coenzyme Q10