title: [Prognosis and therapy of inflammatory rheumatic diseases : Impact of renal manifestations].
abstract: BACKGROUND
  Inflammatory rheumatic diseases and their treatment cause various renal manifestations requiring modification of treatment.
  
  
  OBJECTIVE
  Discussion of renal manifestations in selected rheumatic diseases, including their impact on general prognosis and therapy.
  
  
  METHODS
  Basic literature and expert opinions are analyzed and discussed.
  
  
  RESULTS
  Inflammatory rheumatic diseases and their treatment cause various renal manifestations, including glomerular, tubular, interstitial, and vascular damage. The type of damage determines both, associated clinical symptoms (i.e. hematuria, proteinuria, loss of kidney function) and the renal and overall survival as will be discussed here for rheumatoid arthritis, systemic lupus erythematosus, scleroderma, Sjögrens syndrome, cryoglobulinemia and ANCA-associated vasculitis.
  
  
  CONCLUSIONS
  Renal manifestations are generally indicators of high disease activity and usually require more intensive treatment of the underlying rheumatic disease. Early and rigorous treatment, which has to be adapted to renal function, is capable of improving renal and overall survival in many of the affected patients.
authors.affiliation: Abteilung für Innere Medizin mit Schwerpunkten Nephrologie, Rheumatologie, Gastroenterologie, Immanuel Klinikum Bernau, Herzzentrum Brandenburg, Ladeburger Straße 17, 16321, Bernau, Deutschland, m.zaenker@immanuel.de.
authors.forename: M
authors.initials: M
authors.lastname: Zänker
authors.forename: C D
authors.initials: CD
authors.lastname: Cohen
authors.forename: H D
authors.initials: HD
authors.lastname: Rupprecht
mesh_terms: D015984:Causality; D015897:Comorbidity; D019317:Evidence-Based Medicine; D006801:Humans; D007249:Inflammation / Q000401:mortality* / Q000628:therapy*; D007674:Kidney Diseases / Q000401:mortality* / Q000628:therapy*; D015995:Prevalence; D012216:Rheumatic Diseases / Q000401:mortality* / Q000628:therapy*; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome