title: [The combined effect of lead and zinc on the embryonic development of laboratory rats].
abstract: In the article there are presented the results of the study of the impact of inorganic lead and zinc compounds, as well as their organic forms produced with the use of nanotechnoloy, on the embryonic development of laboratory rats. Metals were orally administered daily during 19 days of gestation at the doses of 0.05 mg/kg of lead, and 1.5 mg/kg of zinc. The impact of the test substances was evaluated by integral and specific indices with the use of physiological, morphological and quantitative methods of analysis. Lead in a dose of 0.05 mg/kg was established to disturb the antenatal development of the offspring of experimental animals, which is pronounced in the increased embryo lethality rate, deterioration of somatometric indices of male fetuses in the litter as compared with the control group, and compared with females. In permits to suggest the greater sensitivity of male fetuses to exposure to lead. The isolated impact of zinc in the dose of 1.5 mg/kg body weight does not influence on the levels of embrio mortality rate, as well as somatometric indices of fetuses. However, the combined administration of the compounds of zinc and lead weakens the embryotoxic effect of the latter in terms of embrio lethality and the amount of live fetuses in the litter with more effective bioprotection for zinc in the nanoaquachelate form.
authors.forename: E N
authors.initials: EN
authors.lastname: Bezetskaia
authors.forename: N M
authors.initials: NM
authors.lastname: Onul
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000196:embryology; D007854:Lead / Q000633:toxicity*; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar / Q000196:embryology*; D015032:Zinc / Q000633:toxicity*
chemical_list: D007854:Lead; D015032:Zinc