title: Chemical constituents and derivatization of melodorinol from the roots of Melodorum fruticosum.
abstract: Chemical investigation of the CH2Cl2 and MeOH crude extracts of the roots of Melodorum fruticosum Lour. led to the isolation of 15 known compounds, of which 5, 10, and 12-15 are reported for the first time from this plant. In addition, melodorinol (7) was derivatized to afford six new (7a-7d and 7f-7g) analogues and one known compound (7e). Their structures were identified on the basic of spectroscopic data Most of them were evaluated for their cytotoxicity against KB, HeLa, MCF-7 and HepG-2 cell lines. Compounds 4 and 7b were the most potent to all cell lines.
authors.forename: Siriwat
authors.initials: S
authors.lastname: Hongnak
authors.forename: Jongkolnee
authors.initials: J
authors.lastname: Jongaramruong
authors.forename: Suttira
authors.initials: S
authors.lastname: Khumkratok
authors.forename: Pongpun
authors.initials: P
authors.lastname: Siriphong
authors.forename: Santi
authors.initials: S
authors.lastname: Tip-pyang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000972:Antineoplastic Agents, Phytogenic; C070779:melodorinol