title: [Correlation between the Expression of microRNA 451 in Red Blood Cells and Chronic Mountain Sickness].
abstract: OBJECTIVE
  To investigate the correlation between the expression of microRNA-451 in red blood cells and chronic mountain sickness(CMS).
  
  
  METHODS
  Peripheral blood samples were collected from emigrant CMS patients (28 cases), localized CMS patients (12 case), emigrant healthy people (24 case) and localized healthy people (22 case). The microRNA-451 expression in red blood cells was measured by the RT-PCR. The results combined with the clinical data of patients were analysed.
  
  
  RESULTS
  The expression of microRNA-451 in emigrant CMS patients was higher than that in emigrant healthy people (P<0.05); the expression of microRNA-451 in localized CMS patients was higher than that in localized healthy people (P<0.05); the microRNA-451 expression had no statistical difference between emargant and localized healthy people. The level of hemoglobin in CMS patients was positively correlated with the expression of microRNA-451 in red cells (r=0.701).
  
  
  CONCLUSIONS
  There is a certain level of microRNA-451 in healthy people, the expression of microRNA-451 in CMS patients is significantly higher than that in healthy people. MicroRNA-451 may play an important role in the process of chronic mountain sickness.
authors.affiliation: Second Department of Geriatrics, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China.
authors.forename: Zhuo-Ya
authors.initials: ZY
authors.lastname: Wang
authors.affiliation: Second Department of Geriatrics, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China. E-mail: qdfyyfm@163.com.
authors.forename: Fa-Man
authors.initials: FM
authors.lastname: Yang
authors.affiliation: Second Department of Geriatrics, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Liu
authors.affiliation: Second Department of Geriatrics, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Li
authors.affiliation: Second Department of Geriatrics, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Li
authors.affiliation: Second Department of Geriatrics, Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China.
authors.forename: Ze-Hui
authors.initials: ZH
authors.lastname: Jing
mesh_terms: D000532:Altitude Sickness; D002908:Chronic Disease; D004912:Erythrocytes; D006454:Hemoglobins; D006801:Humans; D035683:MicroRNAs
chemical_list: D006454:Hemoglobins; D035683:MicroRNAs