title: Sex differences in interactions between nucleus accumbens and visual cortex by explicit visual erotic stimuli: an fMRI study.
abstract: Men tend to have greater positive responses than women to explicit visual erotic stimuli (EVES). However, it remains unclear, which brain network makes men more sensitive to EVES and which factors contribute to the brain network activity. In this study, we aimed to assess the effect of sex difference on brain connectivity patterns by EVES. We also investigated the association of testosterone with brain connection that showed the effects of sex difference. During functional magnetic resonance imaging scans, 14 males and 14 females were asked to see alternating blocks of pictures that were either erotic or non-erotic. Psychophysiological interaction analysis was performed to investigate the functional connectivity of the nucleus accumbens (NA) as it related to EVES. Men showed significantly greater EVES-specific functional connection between the right NA and the right lateral occipital cortex (LOC). In addition, the right NA and the right LOC network activity was positively correlated with the plasma testosterone level in men. Our results suggest that the reason men are sensitive to EVES is the increased interaction in the visual reward networks, which is modulated by their plasma testosterone level.
authors.affiliation: Korea Advanced Institute of Science and Technology (KAIST), Laboratory of Clinical Neuroscience and Development, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Lee
authors.affiliation: Korea Advanced Institute of Science and Technology (KAIST), Laboratory of Clinical Neuroscience and Development, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea.
authors.forename: B S
authors.initials: BS
authors.lastname: Jeong
authors.affiliation: Department of Psychiatry, Daejeon St Mary's Hospital, The Catholic University of Korea, College of Medicine, Daejeon, Republic of Korea.
authors.forename: J
authors.initials: J
authors.lastname: Choi
authors.affiliation: Department of Psychiatry, College of Medical Science, Kongyang University, Daejeon, Republic of Korea.
authors.forename: J-W
authors.initials: JW
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D004882:Erotica / Q000523:psychology*; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009714:Nucleus Accumbens / Q000502:physiology*; D010775:Photic Stimulation; D012727:Sex Characteristics; D013739:Testosterone / Q000097:blood; D014793:Visual Cortex / Q000502:physiology*; D055815:Young Adult
chemical_list: D013739:Testosterone