title: [Tryptophan and nicotinic acid as antioxidants in different age rats brain at the immobilization stress].
abstract: It is testified that the intensity of lipid peroxidation (LP) in the brain of old and mature rats did not differ significantly. Stress-effects in the form of immobilization led to activation of the LP and inhibition of antioxidant activity (AOA) in the brain mainly in aged rats. The simultaneous introduction of tryptophan and nicotinic acid reduced negative changes of LP and AOA in the brain of old rats caused by immobilization stress exposure. In the brain of mature rats, the combination of tryptophan and nicotinic acid in normal and immobilization decreased the level of LP and increased the intensity of AOA. The increased activity of antioxidant system in the brain of rats by complex of tryptophan and nicotinic acid demonstrated its protective antioxidant properties.
authors.forename: D L
authors.initials: DL
authors.lastname: Shcherbakov
authors.forename: V V
authors.initials: VV
authors.lastname: Emel'ianov
authors.forename: V N
authors.initials: VN
authors.lastname: Meshchaninov
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D004359:Drug Therapy, Combination; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D009525:Niacin / Q000008:administration & dosage / Q000627:therapeutic use*; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D016896:Treatment Outcome; D014364:Tryptophan / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D009525:Niacin; D014364:Tryptophan