title: Association of MRS-Based Vertebral Bone Marrow Fat Fraction with Bone Strength in a Human In Vitro Model.
abstract: Bone marrow adiposity has recently gained attention due to its association with bone loss pathophysiology. In this study, ten vertebrae were harvested from fresh human cadavers. Trabecular BMD and microstructure parameters were extracted from MDCT. Bone marrow fat fractions were determined using single-voxel MRS. Failure load (FL) values were assessed by destructive biomechanical testing. Significant correlations (P < 0.05) were observed between MRS-based fat fraction and MDCT-based parameters (up to r = -0.72) and MRS-based fat fraction and FL (r = -0.77). These findings underline the importance of the bone marrow in the pathophysiology and imaging diagnostics of osteoporosis.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.
authors.forename: Dimitrios C
authors.initials: DC
authors.lastname: Karampinos
authors.affiliation: Department of Diagnostic and Interventional Radiology, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Ruschke
authors.affiliation: Department of Diagnostic and Interventional Radiology, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.
authors.forename: Olga
authors.initials: O
authors.lastname: Gordijenko
authors.affiliation: Department of Orthopedic Surgery, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Grande Garcia
authors.affiliation: Philips Healthcare, Lübeckertordamm 5, 20099 Hamburg, Germany.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Kooijman
authors.affiliation: Department of Orthopedic Surgery, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Burgkart
authors.affiliation: Department of Diagnostic and Interventional Radiology, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Rummeny
authors.affiliation: Section of Neuroradiology, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.
authors.forename: Jan S
authors.initials: JS
authors.lastname: Bauer
authors.affiliation: Department of Diagnostic and Interventional Radiology, Technische Universität München, Ismaninger Straße 22, 81675 Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Baum