title: Enhanced fitness and renal function in Type 2 diabetes.
abstract: OBJECTIVE
  To investigate the renal effects of fitness in people with diabetes with mild renal dysfunction.
  
  
  METHODS
  The effect of a 12-week exercise programme on estimated GFR in 128 people with diabetes was evaluated.
  
  
  RESULTS
  All cardiometabolic variables improved after 12 weeks of supervised exercise. Although there was a modest 3.9% increase in estimated GFR from baseline in the 128 people who completed the study, those with baseline chronic kidney disease stages 2 and 3 were found to have significant (6 and 12%, respectively; p < 0.01) improvements in post-exercise estimated GFR. Moreover, 42% of the people with chronic kidney disease stage 3 improved to chronic kidney disease stage 2 after the intervention.
  
  
  CONCLUSIONS
  Short-term exercise improves renal function in those with more moderate baseline chronic kidney disease. Thus, renal function appears to be responsive to enhanced physical fitness. Being a strong and modifiable risk factor, enhanced fitness should be considered a non-pharmacological adjunct in the management of diabetic kidney disease.
authors.affiliation: Department of Endocrinology, Veterans Affairs Medical Center, Washington, DC, USA.|Department of Endocrinology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Nylen
authors.affiliation: Department of Endocrinology, Veterans Affairs Medical Center, Washington, DC, USA.|Department of Endocrinology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Gandhi
authors.affiliation: Department of Geriatrics, Veterans Affairs Medical Center, Washington, DC, USA.
authors.forename: R
authors.initials: R
authors.lastname: Kheirbek
authors.affiliation: Department of Cardiology, Veterans Affairs Medical Center, Washington, DC, USA.|Department of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.|Department of Cardiology, Georgetown University School of Medicine, Washington, DC, USA.
authors.forename: P
authors.initials: P
authors.lastname: Kokkinos
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D003928:Diabetic Nephropathies / Q000503:physiopathology / Q000628:therapy*; D015444:Exercise / Q000502:physiology; D005081:Exercise Therapy; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010809:Physical Fitness / Q000502:physiology*; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology / Q000628:therapy*