title: Spectroscopic studies of nucleic acid additions during seed-mediated growth of gold nanoparticles.
abstract: The effect of adding nucleic acids to gold seeds during the growth stage of either nanospheres or nanorods was investigated using UV-Vis spectroscopy to reveal any oligonucleotide base or structure-specific effects on nanoparticle growth kinetics or plasmonic signatures. Spectral data indicate that the presence of DNA duplexes during seed ageing drastically accelerated nanosphere growth while the addition of single-stranded polyadenine at any point during seed ageing induces nanosphere aggregation. For seeds added to a gold nanorod growth solution, single-stranded polythymine induces a modest blue-shift in the longitudinal peak wavelength. Moreover, a particular sequence comprised of 50% thymine bases was found to induce a faster, more dramatic blue-shift in the longitudinal peak wavelength compared to any of the homopolymer incubation cases. Monomeric forms of the nucleic acids, however, do not yield discernable spectral differences in any of the gold suspensions studied.
authors.affiliation: School of Materials Science and Engineering, Georgia Institute of Technology, 771 Ferst Dr. NW, Atlanta, GA 30332-0245, USA.
authors.forename: Maeling
authors.initials: M
authors.lastname: Tapp
authors.affiliation: School of Materials Science and Engineering, Georgia Institute of Technology, 771 Ferst Dr. NW, Atlanta, GA 30332-0245, USA.
authors.forename: Rick
authors.initials: R
authors.lastname: Sullivan
authors.affiliation: Materials & Manufacturing Directorate, Soft Matter Materials Branch, Air Force Research Laboratory, Wright Patterson AFB, OH 45433, USA.
authors.forename: Patrick
authors.initials: P
authors.lastname: Dennis
authors.affiliation: Materials & Manufacturing Directorate, Soft Matter Materials Branch, Air Force Research Laboratory, Wright Patterson AFB, OH 45433, USA.
authors.forename: Rajesh R
authors.initials: RR
authors.lastname: Naik
authors.affiliation: School of Materials Science and Engineering, Georgia Institute of Technology, 771 Ferst Dr. NW, Atlanta, GA 30332-0245, USA ; Wallace C. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 771 Ferst Dr. NW, Atlanta, GA 30332-0245, USA ; Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 771 Ferst Dr. NW, Atlanta, GA 30332-0245, USA.
authors.forename: Valeria T
authors.initials: VT
authors.lastname: Milam
keywords: Au; biomimetic; colloid