title: Biomarkers Related to Carotid Intima-Media Thickness and Plaques in Long-Term Survivors of Ischemic Stroke.
abstract: Lifestyle risk factors, inflammation and genetics play a role in the development of atherosclerosis. We therefore studied Fc gamma receptor (FcγR) polymorphisms, interleukin (IL)-10 polymorphisms and other biomarkers related to carotid intima-media thickness (cIMT) in patients with ischemic stroke at a young age. Patients were evaluated 12 years after stroke occurrence. Patients (n = 232) 49 years of age or younger with an index stroke between 1988 and 1997 were retrospectively selected. Blood samples were taken at a first follow-up 6 years after the stroke. At a second follow-up, additional arterial events were registered for 140 patients, new blood samples were taken, and measurements of cIMT and blood pressure (BP) were performed. Unadjusted logistic regression analysis showed that cIMT ≥1 mm was associated with age, male gender, additional arterial events, BP, cholesterol, sedimentation rate, haemoglobin, triglycerides, creatinine, glycolysed haemoglobin (HbA1c) and FcγRIIIB-NaII/NaII. Adjusted backward stepwise logistic regression showed significance for age (odds ratio (OR) 1.13, 95% confidence interval (CI) 1.04 to1.23, p = 0.003), male gender (OR 4.07, 95% CI 1.15 to 14.5, p = 0.030), HbA1c (OR 6.65, 95% CI 1.21 to 36.5, p = 0.029) and FcγRIIIB-NaII/NaII (OR 3.94, 95% CI 1.08 to 14.3, p = 0.037). In this long-term follow-up study of patients with ischemic stroke at a young age, FcγRIIIB-NaII/NaII was identified as a possible contributing factor for cIMT ≥1 mm together with known risk factors, such as age, male gender, systolic BP, additional arterial events and HbA1c.
authors.affiliation: Department of Neurology, Haukeland University Hospital, Jonas Lies vei 65, N-5021, Bergen, Norway, uwan@helse-bergen.no.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Waje-Andreassen
authors.forename: Halvor
authors.initials: H
authors.lastname: Naess
authors.forename: Lars
authors.initials: L
authors.lastname: Thomassen
authors.forename: Tove Helene
authors.initials: TH
authors.lastname: Maroy
authors.forename: Kibret Yimer
authors.initials: KY
authors.lastname: Mazengia
authors.forename: Geir Egil
authors.initials: GE
authors.lastname: Eide
authors.forename: Christian Alexander
authors.initials: CA
authors.lastname: Vedeler
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D001799:Blood Sedimentation; D002545:Brain Ischemia / Q000150:complications; D002097:C-Reactive Protein / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D017452:Receptors, IgG / Q000235:genetics; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke / Q000378:metabolism* / Q000473:pathology*; D017741:Survivors
chemical_list: D015415:Biomarkers; D017452:Receptors, IgG; D006710:Homocysteine; D016753:Interleukin-10; D002097:C-Reactive Protein; D002784:Cholesterol