title: [Effect of Compound Zaofan Pill on Bone Marrow MVD and VEGF of Patients with Chronic Aplastic Anemia].
abstract: OBJECTIVE
  To investigate the clinical efficacy of compound Zaofan pill combined with cyclosporine and androgen for treatment of patients with chronical aplastic anemia(CAA), and its effect on bone marrow microvessel density(MVD) and vascular endothelial growth factor(VEGF) of CAA patients.
  
  
  METHODS
  A total of 76 cases of CAA were randomly divided into group 1 and group 2, among them the group 1 (38 cases) was treated with cyclosporine and androgen alone, while the group 2(38 cases) was treated with compound Zaofan pill combined with cyclosporine and androgen. Samples of 20 cases with normal bone marrow were used as controls. The clinical effects of each groups were observed, and the mean bone marrow MVD and VEGF levels were detected before and after half a year's treatment.
  
  
  RESULTS
  The mean bone marrow MVD and VEGF levels in CAA group before treatment were significantly lower than that in normal control group, but bone marrow MVD and VEGF levels in 2 groups significantly increased after treatment. Group 1 showed the cure and response rate of 15.8%, while group 2 showed the cure and response rate of 44.7%, there was significant difference between the two groups (P<0.05)). There was no significant difference of bone marrow MVD and VEGF expression before treatment between group 1 and group 2. After treatment, bone marrow MVD and VEGF expression of group 2 were significantly higher than pre-treatment, moreover the bone marrow MVD and VEGF expression in group 2 were significantly higher than that in group 1.
  
  
  CONCLUSIONS
  The compound Zaofan pill combined with cyclosporine and androgen can obviously increase the levels of MVD and VEGF in bone marrow, and improve the efficacy of treatment in CAA patients.
authors.affiliation: Department of Hematology, Guangzhou Nansha Central Hospital, Guangzhou 511457, Guangdong Province, China. E-mail: kunyangkun@sina.com.
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Yang
authors.affiliation: Department of Pathology, Guangzhou Nansha Central Hospital, Guangzhou 511457, Guangdong Province, China.
authors.forename: Kang-Wei
authors.initials: KW
authors.lastname: Wang
authors.affiliation: Department of Hematology, Guangzhou Nansha Central Hospital, Guangzhou 511457, Guangdong Province, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Xiang
authors.affiliation: Department of Hematology, Guangzhou Municipal First People's Hospital, Guangzhou Medical Univesity, Guangzhou 510080, Guangdong Province, China.
authors.forename: Shun-Qing
authors.initials: SQ
authors.lastname: Wang
mesh_terms: D000741:Anemia, Aplastic; D001853:Bone Marrow; D016572:Cyclosporine; D006801:Humans; D042461:Vascular Endothelial Growth Factor A
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016572:Cyclosporine