title: Correlation between Serum Level of Monocyte Chemoattractant Protein-1 and Postoperative Recurrence of Spinal Tuberculosis in the Chinese Han Population.
abstract: OBJECTIVE
  To correlate serum level of monocyte chemoattractant protein-1 (MCP-1) with postoperative recurrence of spinal tuberculosis in the Chinese Han population.
  
  
  METHODS
  Patients of Han nationality with newly diagnosed spinal tuberculosis were consecutively included in this study. At different time points postoperatively, serum level of MCP-1 was determined using an enzyme linked immunosorbent assay. Recurrence of spinal tuberculosis after surgery and during the follow-up period was recorded. The correlation between serum MCP-1 level and recurrence of spinal tuberculosis was analyzed.
  
  
  RESULTS
  A total of 169 patients with spinal tuberculosis were included in the study and followed up for an average of 2.2 ± 1.3 years (range, 1-5 years). Of these patients, 11 had postoperative recurrence of spinal tuberculosis. The patients' serum level of MCP-1 increased significantly after postoperative recurrence of spinal tuberculosis. Once the symptoms of recurrence were cured, the serum level of MCP-1 decreased significantly and it did not differ from patients without disease recurrence.
  
  
  CONCLUSIONS
  Postoperative recurrence of spinal tuberculosis is likely to increase the serum level of MCP-1.
authors.affiliation: Department of Neurology, The First Hospital of Changsha, Changsha, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: He
authors.affiliation: DepartmentofOrthopedics, The second affiliated Hospital, Fujian Medical University, Quanzhou, People's Republic of China.
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Qile
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Clinical Laboratory, The second affiliated Hospital, Fujian Medical University, Quanzhou, People's Republic of China.
authors.forename: Rongfu
authors.initials: R
authors.lastname: Huang
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Zhansheng
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Chaofeng
authors.initials: C
authors.lastname: Guo
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Guo
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Jia
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Spine Surgery, Xiangya Spinal Surgery Center, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
authors.forename: Hongqi
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018932:Chemokine CCL2 / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012008:Recurrence; D014057:Tomography, X-Ray Computed; D014399:Tuberculosis, Spinal / Q000097:blood* / Q000175:diagnosis / Q000382:microbiology* / Q000601:surgery; D055815:Young Adult
chemical_list: D018932:Chemokine CCL2