title: Innate response activator B cells: origins and functions.
abstract: Innate response activator (IRA) B cells are a subset of B-1a derived B cells that produce the growth factors granulocyte macrophage colony stimulating factor and IL-3. In mouse models of sepsis and pneumonia, B-1a B cells residing in serosal sites recognize bacteria, migrate to the spleen or lung, and differentiate to IRA B cells that then contribute to the host response by amplifying inflammation and producing polyreactive IgM. In atherosclerosis, IRA B cells accumulate in the spleen, where they promote extramedullary hematopoiesis and activate classical dendritic cells. In this review, we focus on the ontogeny and function of IRA B cells in acute and chronic inflammation.
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Simches Research Building, 185 Cambridge St., Boston, MA 02114, USA bchouster@gmail.com.
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Chousterman
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Simches Research Building, 185 Cambridge St., Boston, MA 02114, USA.
authors.forename: Filip K
authors.initials: FK
authors.lastname: Swirski
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D019070:Cell Lineage / Q000276:immunology*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000276:immunology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics / Q000276:immunology; D007113:Immunity, Innate; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000235:genetics; D007377:Interleukin-3 / Q000235:genetics / Q000276:immunology; D008168:Lung / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D051379:Mice; D011014:Pneumonia / Q000235:genetics / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D018805:Sepsis / Q000235:genetics / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D015398:Signal Transduction; D013154:Spleen / Q000276:immunology / Q000382:microbiology / Q000473:pathology
chemical_list: C508596:IL3 protein, human; D007075:Immunoglobulin M; D007377:Interleukin-3; D016178:Granulocyte-Macrophage Colony-Stimulating Factor
keywords: B1a cells; GM-CSF; IL-3; IRA B cells; IgM; innate immunity