title: Novel surgical options for gastroesophageal reflux disease.
abstract: There are limited options to patients with gastroesophageal reflux disease (GERD) who are not satisfied with acid suppression therapy. Fundoplication, the standard surgical procedure for GERD, is effective but is associated with adverse side effects and has thus been performed less frequently, creating a need for alternative surgical interventions that are effective, yet less invasive and reversible. Lately, two such interventions were developed: the magnetic sphincter augmentation and electrical stimulation of the lower esophageal sphincter. Human studies describing safety and efficacy over a follow-up period of a number of years have been published, documenting efficacy and safety of these interventions. Future studies should clarify the role of these procedures in the spectrum of GERD therapy.
authors.affiliation: Department of Medicine, Keck School of Medicine, University of Southern California, 1520 San Pablo Street, Los Angeles, CA 90033, USA.
authors.forename: Jenny
authors.initials: J
authors.lastname: Chiu
authors.forename: Edy
authors.initials: E
authors.lastname: Soffer
mesh_terms: D000818:Animals; D004599:Electric Stimulation Therapy / Q000009:adverse effects; D004567:Electrodes, Implanted / Q000009:adverse effects; D049630:Esophageal Sphincter, Lower / Q000601:surgery*; D005764:Gastroesophageal Reflux / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D059346:Magnets / Q000009:adverse effects
keywords: Nissen fundoplication; electrical stimulation; gastroesophageal reflux disease; lower esophageal sphincter; magnetic sphincter augmentation