title: Bronchial myeloid sarcoma with concurrent Aspergillus fumigatus infection in a patient presenting with hemoptysis.
abstract: Myeloid sarcoma (MS) is an extramedullary myeloid neoplasm characterized by proliferation of myeloblasts which can occur in any organ or site. Bronchial and pulmonary involvement, however, is uncommon. We describe a case of bronchial MS in an 81-year-old female with a history of high-grade myelodysplastic syndrome; she was started on treatment few months before, and she presented with fever, cough and profuse hemoptysis. She was found to be pancytopenic with bilateral airspace consolidations, most notably in the right upper and lower lobes, on imaging studies. She was treated with broad-spectrum antibiotics and antifungals without much improvement in her clinical or radiological status. Ultimately, biopsy of the lung lesions showed myeloid sarcoma with concurrent Aspergillus fumigatus infection. Bronchial/pulmonary MS should be considered in the list of differential diagnoses in a patient with a history of myeloid neoplasm and presenting with respiratory related symptoms, as early administration of chemotherapy may help to improve survival rates.
authors.affiliation: Department of Medicine, Staten Island University Hospital, Staten Island, NY, 10305, USA.
authors.forename: Adarsh
authors.initials: A
authors.lastname: Vennepureddy
authors.forename: Gautam
authors.initials: G
authors.lastname: Valecha
authors.forename: Srujitha
authors.initials: S
authors.lastname: Murukutla
authors.forename: Shafinaz
authors.initials: S
authors.lastname: Hussein
authors.forename: Terenig
authors.initials: T
authors.lastname: Terjanian
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D001232:Aspergillus fumigatus; D001706:Biopsy; D001984:Bronchial Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006469:Hemoptysis / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D013902:Radiography, Thoracic; D023981:Sarcoma, Myeloid / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy
keywords: Aspergillus fumigatus; hemoptysis; myelodysplastic syndrome; myeloid sarcoma