title: Diffuse pulmonary meningotheliomatosis: A diagnostically challenging entity on fine-needle aspiration cytology.
abstract: Diffuse pulmonary meningotheliomatosis (DPM) is an exceedingly rare entity consisting of multiple minute pulmonary meningothelial-like nodules profusely involving the lungs. To the best of our knowledge, we present the first cytologic description of this uncommon lesion from a 57-year-old nonsmoking woman. Computerized tomographic-guided fine-needle aspiration cytology from a left upper lobe nodule showed whorled/nested clusters of elongated cells with oval nuclei, clear pseudonuclear inclusions, nuclear grooves/indentations, smooth nuclear contours, fine granular chromatin, inconspicuous nucleoli, and abundant fibrillary cytoplasm with indistinct cell borders. The subsequent pulmonary wedge resections confirmed the diagnosis of DPM. As this condition is exceptionally rare, familiarity with these cytologic features is of the essence to accurately establish this challenging diagnosis.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, California.
authors.forename: Eric C
authors.initials: EC
authors.lastname: Huang
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, California.
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, California.
authors.forename: John W
authors.initials: JW
authors.lastname: Bishop
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, California.
authors.forename: Regina F
authors.initials: RF
authors.lastname: Gandour-Edwards
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, California.
authors.forename: Alaa M
authors.initials: AM
authors.lastname: Afify
mesh_terms: D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008168:Lung / Q000166:cytology* / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed
keywords: cytology; diffuse pulmonary meningotheliomatosis; fine-needle aspiration; minute pulmonary meningothelial-like nodules