title: Development of ocular hypertension secondary to tamponade with light versus heavy silicone oil: A systematic review.
abstract: OBJECTIVE
  The intraocular silicone oil (SO) tamponades used in the treatment of retinal detachment (RD) have been associated with a difference ocular hypertension (OH) rate. To clarify, if this complication was associated to use of standard SO (SSO) versus heavy SO (HSO), we performed a systematic review and meta-analysis of comparative study between two kind of SO (standard or light vs. heavy) for the treatment of RD and macular hole, without restriction to study design.
  
  
  METHODS
  The methodological quality of two randomized clinical trials (RCTs) were evaluated using the criteria given in the Cochrane Handbook for Systematic Reviews of Intervention, while three non-RCTs were assessed with the Newcastle-Ottawa Scale and Strengthening the Reporting of Observational Studies in Epidemiology checklists. We calculated Mantel-Haenszel risk ratio (RR) with 95% confidence intervals (95% CIs). The primary outcome was the rate of patients with OH treated with SSO compared to HSO.
  
  
  RESULTS
  There were a higher number of rates of OH in HSO compared to SSO. This difference was statistically significant with the fixed effect model (Mantel-Haenszel RR; 1.55; 95% CI, 1.06-2.28; P = 0.02) while there was not significative difference with the random effect model (Mantel-Haenszel RR; 1.51; 95% CI, 0.98-2.33; P = 0.06).
  
  
  CONCLUSIONS
  We noted a trend that points out a higher OH rate in HSO group compared to SSO, but this finding, due to the small size and variable design of studies, needs to be confirmed in well-designed and large size RCTs.
authors.affiliation: Department of Ophthalmology, Second University of Naples, Naples, Italy; Department of Corneal and External Eye Diseases, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom, .
authors.forename: Vito
authors.initials: V
authors.lastname: Romano
authors.forename: Mario
authors.initials: M
authors.lastname: Cruciani
authors.forename: Francesco
authors.initials: F
authors.lastname: Semeraro
authors.forename: Ciro
authors.initials: C
authors.lastname: Costagliola
authors.forename: Mario R
authors.initials: MR
authors.lastname: Romano
mesh_terms: D006801:Humans; D007429:Intraocular Pressure; D009798:Ocular Hypertension / Q000209:etiology* / Q000503:physiopathology; D011183:Postoperative Complications; D012163:Retinal Detachment / Q000601:surgery*; D012827:Silicone Oils / Q000009:adverse effects*; D014821:Vitrectomy / Q000009:adverse effects* / Q000379:methods
chemical_list: D012827:Silicone Oils; C515608:densiron