title: Osmophobia and allodynia are critical factors for suicidality in patients with migraine.
abstract: BACKGROUND
  Sensory hypersensitivities are common phenomena in migraine. We examined the role of sensory hypersensitivities on suicidality in patients with migraine.
  
  
  METHODS
  Patients with migraine (with or without aura) were consecutively recruited from our headache clinic. We asked them if they experienced photophobia, phonophobia, osmophobia, and allodynia during migraine attack. The Mini International Neuropsychiatric Interview was used to diagnose current major depressive disorder (MDD), current generalized anxiety disorder (GAD) and suicidality.
  
  
  RESULTS
  Among 220 subjects, 25.5 % had current MDD, 17.3 % had current GAD, and 31.8 % had suicidality. Patients with suicidality were more like to have a low household income, chronic migraine (CM), medication overuse headache, high headache intensity, osmophobia, allodynia, high disability, MDD, and GAD than those without suicidality. The strongest risk factor for suicidality by multivariate analyses was osmophobia (adjusted Odds Ratio [AOR] 3.12, 95 % confidence interval [CI] 1.57-6.21, p = 0.001), followed by current MDD (AOR 2.99, 95 % CI 1.33-6.76, p = 0.008), CM (AOR 2.48, 95 % CI 1.21-5.09, p = 0.013), current GAD (AOR 3.11, 95 % CI 1.22-7.91, p = 0.017), and allodynia (AOR 2.72, 95 % CI 1.19-6.21, p = 0.018).
  
  
  CONCLUSIONS
  Osmophobia and allodynia are critical factors for suicidality in patients with migraine, after controlling for depression, anxiety, and CM.
authors.affiliation: Department of Neurology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu, 700-842, Republic of Korea, sppark@mail.knu.ac.kr.
authors.forename: Sung-Pa
authors.initials: SP
authors.lastname: Park
authors.forename: Jong-Geun
authors.initials: JG
authors.lastname: Seo
authors.forename: Won-Kee
authors.initials: WK
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D059350:Chronic Pain / Q000453:epidemiology; D003865:Major Depressive Disorder / Q000453:epidemiology; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000453:epidemiology; D055696:Olfactory Perception; D010698:Phobic Disorders / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors; D013405:Suicide / Q000706:statistics & numerical data*; D055815:Young Adult