title: microRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy.
abstract: We investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were correlated to histological tumor regression, histopathological variables, FDG-PET-CT and survival. MicroRNA-21 was significantly higher in esophagectomies than in corresponding biopsies (p = .027). No association of microRNA-21 or microRNA-148a expression in tissue specimens with other clinical parameters was present. Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of microRNA-21 might represent an escape mechanism of tumor cells.
authors.affiliation: 1Department of Medicine I, Clinical Division of Oncology, Medical University of Vienna, Vienna, Austria.
authors.forename: Aysegül
authors.initials: A
authors.lastname: Ilhan-Mutlu
authors.forename: Gülcin
authors.initials: G
authors.lastname: Tezcan
authors.forename: Sebastian F
authors.initials: SF
authors.lastname: Schoppmann
authors.forename: Matthias
authors.initials: M
authors.lastname: Preusser
authors.forename: Kommata
authors.initials: K
authors.lastname: Spyridoula
authors.forename: Georgios
authors.initials: G
authors.lastname: Karanikas
authors.forename: Peter
authors.initials: P
authors.lastname: Birner
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D000368:Aged; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000096:biosynthesis*; D008875:Middle Aged; D064847:Multimodal Imaging; D020360:Neoadjuvant Therapy; D049268:Positron-Emission Tomography; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed
chemical_list: C550570:MIRN148 microRNA, human; C524940:MIRN21 microRNA, human; D035683:MicroRNAs
keywords: Adenocarcinoma; Esophageal cancer; FDG-PET–CT; Neoadjuvant therapy; microRNA-148a; microRNA-21