title: Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes.
abstract: Macrophage-derived chemokine, C-C motif chemokine 22 (MDC/CCL22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. Serum and skin MDC/CCL22 levels are elevated in atopic dermatitis, which suggests that the chemokines produced from keratinocytes are responsible for attracting inflammatory lymphocytes to the skin. A major signaling pathway in the interferon-γ (IFN-γ)-stimulated inflammation response involves the signal transducers and activators of transcription 1 (STAT1). In the present study, we investigated the anti-inflammatory effect of dieckol and its possible action mechanisms in the category of skin inflammation including atopic dermatitis. Dieckol inhibited MDC/CCL22 production induced by IFN-γ (10 ng/mL) in a dose dependent manner. Dieckol (5 and 10 μM) suppressed the phosphorylation and the nuclear translocation of STAT1. These results suggest that dieckol exhibits anti-inflammatory effect via the down-regulation of STAT1 activation.
authors.affiliation: Departments of Biomedicine & Drug Development.
authors.forename: Na-Jin
authors.initials: NJ
authors.lastname: Kang
authors.affiliation: Departments of Biomedicine & Drug Development.
authors.forename: Dong-Hwan
authors.initials: DH
authors.lastname: Koo
authors.affiliation: Medicine, School of Medicine.
authors.forename: Gyeoung-Jin
authors.initials: GJ
authors.lastname: Kang
authors.affiliation: Medicine, School of Medicine.
authors.forename: Sang-Chul
authors.initials: SC
authors.lastname: Han
authors.affiliation: Medicine, School of Medicine.
authors.forename: Bang-Won
authors.initials: BW
authors.lastname: Lee
authors.affiliation: Departments of Biomedicine & Drug Development ; Medicine, School of Medicine.
authors.forename: Young-Sang
authors.initials: YS
authors.lastname: Koh
authors.affiliation: Departments of Biomedicine & Drug Development ; Medicine, School of Medicine.
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Hyun
authors.affiliation: Chemistry, College of Natural Science, Jeju National University, Jeju 690-756.
authors.forename: Nam-Ho
authors.initials: NH
authors.lastname: Lee
authors.affiliation: Jeju Biodiversity Research Institute, JejuTechnopark, Jeju 699-943, Republic of Korea.
authors.forename: Mi-Hee
authors.initials: MH
authors.lastname: Ko
authors.affiliation: Departments of Biomedicine & Drug Development ; Medicine, School of Medicine.
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Kang
authors.affiliation: Departments of Biomedicine & Drug Development ; Medicine, School of Medicine.
authors.forename: Eun-Sook
authors.initials: ES
authors.lastname: Yoo
keywords: Dieckol; Inflammation; Keratinocyte; MDC/CCL22; STAT1