title: [Pathological changes after brain ischemia are similar to those observed in Alzheimer disease].
abstract: We studied the influence of ischemia/reperfusion of the middle cerebral artery in the rat's brain on the deferred violation of cognitive functions of the brain which are similar to main symptoms observed in the development of Alzheimer's disease. Using 8-hose radial labyrinth we demonstrated that 6 months after incidence of cerebral ischemia a significant impairment of working memory and a decrease in animals the ability to learn are developed. 7 months after focal cerebral ischemia we could observe the accumulation of a mature amyloid peptide and hyperphosphorylated form of the Tau pro- tein in ipsilateral cerebral hemisphere and of the the beta-amyloid peptide precursor in the contralateral hemisphere. Thus, after an experimental stroke in the brain pathological chanres occur as those typical of Alzheimer's disease.
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.forename: V N
authors.initials: VN
authors.lastname: Manskikh
authors.forename: M V
authors.initials: MV
authors.lastname: Gulyaev
authors.forename: I B
authors.initials: IB
authors.lastname: Pevzner
authors.forename: L D
authors.initials: LD
authors.lastname: Zorova
authors.forename: V A
authors.initials: VA
authors.lastname: Babenko
authors.forename: E Y
authors.initials: EY
authors.lastname: Plotnikov
authors.forename: Y A
authors.initials: YA
authors.lastname: Pirogov
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D008279:Magnetic Resonance Imaging; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051381:Rats
chemical_list: D016229:Amyloid beta-Peptides