title: Efficacy of concomitant use of dexmedetomidine and propofol in tetanus.
abstract: Tetanus is an infectious disease caused by Clostridium tetani, which manifests systemic convulsion and autonomic instability associated with high case fatality. Despite proper medical intervention, management of those symptoms is often difficult. We report a case of 67-year-old man with tetanus in which a concomitant use of dexmedetomidine, an adrenaline α-2 receptor agonist, and propofol, a GABA(A) receptor binding agent, was successful in the management of systemic convulsion and autonomic instability without necessitating conventional anticonvulsant, neuromuscular blocking agents, or tracheostomy.
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Miya
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
authors.forename: Nobutake
authors.initials: N
authors.lastname: Shimojo
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Koyama
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Enomoto
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Hagiya
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamasaki
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Nishino
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kawano
authors.affiliation: Department of Emergency and Critical Care Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan. Electronic address: mizutani@md.tsukuba.ac.jp.
authors.forename: Taro
authors.initials: T
authors.lastname: Mizutani
mesh_terms: D000368:Aged; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D015742:Propofol / Q000627:therapeutic use*; D013742:Tetanus / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D015742:Propofol