title: Design and functionalities of the MADOR® software suite for dose-reduction management after DTPA therapy.
abstract: A software suite on biokinetics of radionuclides and internal dosimetry intended for the occupational health practitioners of nuclear industry and for expert opinions has been developed under Borland C++ Builder™. These computing tools allow physicians to improve the dosimetric follow-up of workers in agreement with the French regulations and to manage new internal contaminations by radionuclides such as Pu and/or Am after diethylene triamine penta-acetic acid treatments. In this paper, the concept and functionalities of the first two computing tools of this MADOR(®) suite are described. The release 0.0 is the forensic application, which allows calculating the derived recording levels for intake by inhalation or ingestion of the main radioisotopes encountered in occupational environment. Indeed, these reference values of activity are convenient to interpret rapidly the bioassay measurements and make decisions as part of medical monitoring. The release 1.0 addresses the effect of DTPA treatments on Pu/Am biokinetics and the dose benefit. The forensic results of the MADOR(®) suite were validated by comparison with reference data.
authors.affiliation: CEA/DSV/iRCM 18 route du Panorama, BP 6, F-92265 Fontenay-aux-Roses, France bruno.leprince@cea.fr.
authors.forename: B
authors.initials: B
authors.lastname: Leprince
authors.affiliation: CEA/DSV/iRCM 18 route du Panorama, BP 6, F-92265 Fontenay-aux-Roses, France.
authors.forename: P
authors.initials: P
authors.lastname: Fritsch
authors.affiliation: CEA/DSV/PROSITON 18 route du Panorama, BP 6, F-92265 Fontenay-aux-Roses, France.
authors.forename: P
authors.initials: P
authors.lastname: Bérard
authors.affiliation: CEA/DSV/iRCM 18 route du Panorama, BP 6, F-92265 Fontenay-aux-Roses, France.
authors.forename: P-H
authors.initials: PH
authors.lastname: Roméo
mesh_terms: D000576:Americium / Q000009:adverse effects* / Q000032:analysis; D001822:Body Burden; D002614:Chelating Agents / Q000008:administration & dosage; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D016273:Occupational Exposure / Q000009:adverse effects*; D004369:Pentetic Acid / Q000008:administration & dosage*; D011005:Plutonium / Q000009:adverse effects* / Q000032:analysis; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000517:prevention & control*; D011874:Radiometry; D012984:Software
chemical_list: D002614:Chelating Agents; D011005:Plutonium; D004369:Pentetic Acid; D000576:Americium