title: The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of [(18)F]-fluoro-deoxy-glucose.
abstract: We investigated the impact of oxygenation status (measured by EPR oximetry) on the uptake of (18)F-FDG (measured by PET) in two different tumor models during a carbogen breathing challenge. We observed a significant drop in (18)F-FDG uptake under carbogen breathing that suggests a rapid metabolic adaptation to the oxygen environment.
authors.affiliation: Biomedical Magnetic Resonance Research Group, Université catholique de Louvain (UCL), Belgium.
authors.forename: Marie-Aline
authors.initials: MA
authors.lastname: Neveu
authors.affiliation: Radiation Oncology Department & Center for Molecular Imaging, Université catholique de Louvain (UCL), Belgium.
authors.forename: Vanesa
authors.initials: V
authors.lastname: Bol
authors.affiliation: Radiation Oncology Department & Center for Molecular Imaging, Université catholique de Louvain (UCL), Belgium.
authors.forename: Anne
authors.initials: A
authors.lastname: Bol
authors.affiliation: Pole of Pharmacology and Therapeutics, Université catholique de Louvain (UCL), Belgium.
authors.forename: Caroline
authors.initials: C
authors.lastname: Bouzin
authors.affiliation: Radiation Oncology Department & Center for Molecular Imaging, Université catholique de Louvain (UCL), Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Grégoire
authors.affiliation: Pole of Pharmacology and Therapeutics, Université catholique de Louvain (UCL), Belgium.
authors.forename: Olivier
authors.initials: O
authors.lastname: Feron
authors.affiliation: Biomedical Magnetic Resonance Research Group, Université catholique de Louvain (UCL), Belgium.
authors.forename: Benedicte F
authors.initials: BF
authors.lastname: Jordan
authors.affiliation: Biomedical Magnetic Resonance Research Group, Université catholique de Louvain (UCL), Belgium. Electronic address: bernard.gallez@uclouvain.be.
authors.forename: Bernard
authors.initials: B
authors.lastname: Gallez
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000378:metabolism*; D004195:Disease Models, Animal; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D000860:Hypoxia / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000378:metabolism; D010092:Oximetry; D010100:Oxygen / Q000008:administration & dosage / Q000378:metabolism*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D002245:Carbon Dioxide; C011700:carbogen; D010100:Oxygen
keywords: (18)F-FDG-PET; Carbogen; EPR; Tumor oxygenation