title: Regulation of NF-κB signalling cascade by immunophilins.
abstract: The fine regulation of signalling cascades is a key event required to maintain the appropriate functional properties of a cell when a given stimulus triggers specific biological responses. In this sense, cumulative experimental evidence during the last years has shown that high molecular weight immunophilins possess a fundamental importance in the regulation of many of these processes. It was first discovered that TPR-domain immunophilins such as FKBP51 and FKBP52 play a cardinal role, usually in an antagonistic fashion, in the regulation of several members of the steroid receptor family via its interaction with the heat-shock protein of 90-kDa, Hsp90. These Hsp90-associated cochaperones form a functional unit with the molecular chaperone influencing ligand binding capacity, receptor trafficking, and hormone-dependent transcriptional activity. Recently, it was demonstrated that the same immunophilins are also able to regulate the NF-kB signalling cascade in an Hsp90 independent manner. In this article we analize these properties and discuss the relevance of this novel regulatory pathway in the context of the pleiotropic actions managed by NF-kB in several cell types and tissues.
authors.forename: Mariana
authors.initials: M
authors.lastname: Lagadari
authors.forename: Sonia A
authors.initials: SA
authors.lastname: De Leo
authors.forename: Maria F
authors.initials: MF
authors.lastname: Camisay
authors.forename: Mario D
authors.initials: MD
authors.lastname: Galigniana
authors.affiliation: Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales-IQUIBICEN, Universidad de Buenos Aires, Buenos Aires (C1428EGA), Argentina. erlejman@qb.fcen.uba.ar.
authors.forename: Alejandra G
authors.initials: AG
authors.lastname: Erlejman
mesh_terms: D000818:Animals; D018841:HSP90 Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D016328:NF-kappa B / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D015398:Signal Transduction; D022021:Tacrolimus Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D000099159:Tacrolimus Binding Protein 5
chemical_list: D018841:HSP90 Heat-Shock Proteins; D016328:NF-kappa B; D022021:Tacrolimus Binding Proteins; D000099159:Tacrolimus Binding Protein 5; C403485:tacrolimus binding protein 4