title: Increased serum resistin levels correlate with psoriasis: a meta-analysis.
abstract: BACKGROUND
  Recent studies implicate adipokines in the pathogenesis of inflammatory diseases, including psoriasis. In this study we evaluated the significance of serum resistin levels in psoriasis patients using a meta-analysis approach.223 METHODS: Relevant articles were retrieved by searching the following English and Chinese databases: Cochrane Library, PubMed, Springer Link, Chinese Biomedical Database (CBM) and Chinese National Knowledge Infrastructure (CNKI). The retrieved studies were subjected to a thorough screening procedure to identify case-control studies that contained the required data. Data was extracted from each study and Version 12.0 STATA statistical software was employed for statistical analyses.
  
  
  RESULTS
  Nine case-control studies, containing 421 psoriasis patients and 348 healthy controls, were included in this study. The major result of the meta-analysis revealed a statistically significant association between serum resistin levels and psoriasis (SMD=2.22, 95%CI: 1.14-3.29, P<0.001). Subgroup analysis based on ethnicity showed that, compared to the healthy controls, serum resistin levels were markedly higher in psoriasis patients in both Asian and Caucasian populations (Asians: SMD=3.27, 95%CI=1.62~4.91, P<0.001; Caucasians: SMD=0.91, 95%CI=0.28~1.54, P<0.001).
  
  
  CONCLUSIONS
  Based on our results, we conclude that serum resistin level in psoriasis patients is higher than healthy controls, and raises the possibility that elevated serum resistin levels may be a novel diagnostic marker in psoriasis and may predict the occurrence of co-morbidities in psoriasis patients.
authors.affiliation: Dermatological Department, the First People's Hospital of YueYang, Dong Mao Ling Road No.39, YueYang, 414000, P.R. China. huanghuiyun0416@163.com.
authors.forename: Huiyun
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Oncology, the First People's Hospital of YueYang, YueYang, 414000, P.R. China. shenerdong0416@163.com.
authors.forename: Erdong
authors.initials: E
authors.lastname: Shen
authors.affiliation: Dermatological Department, the First People's Hospital of YueYang, Dong Mao Ling Road No.39, YueYang, 414000, P.R. China. tangshiqing0416@163.com.
authors.forename: Shiqing
authors.initials: S
authors.lastname: Tang
authors.affiliation: Dermatological Department, the First People's Hospital of YueYang, Dong Mao Ling Road No.39, YueYang, 414000, P.R. China. tanxingyou504@163.com.
authors.forename: Xingyou
authors.initials: X
authors.lastname: Tan
authors.affiliation: Dermatological Department, the First People's Hospital of YueYang, Dong Mao Ling Road No.39, YueYang, 414000, P.R. China. guoxiuli619@163.com.
authors.forename: Xiuli
authors.initials: X
authors.lastname: Guo
authors.affiliation: Dermatological Department, the First People's Hospital of YueYang, Dong Mao Ling Road No.39, YueYang, 414000, P.R. China. wangqiangwq619@163.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Dermatological Department, the First People's Hospital of YueYang, Dong Mao Ling Road No.39, YueYang, 414000, P.R. China. dinghongwei619@163.com.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Ding
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000209:etiology; D052243:Resistin / Q000097:blood*
chemical_list: D052243:Resistin