title: [Advances in Association of Estrogen and Human Non-small Cell Lung Cancer].
abstract: Lung cancer, of which approximately 85% are non-small cell lung cancer (NSCLC), is the most leading cause of cancer mortality throughout the world. Despite recent improvements in its treatment, it still remains a highly lethal disease. It is becoming increasingly clear that estrogen and estrogen receptors are involve in the pathogenesis and development of lung cancer. Estrogen receptor modulators and aromatase inhibitor may reverse the drug-resistance of platinum based chemotherapy in NSCLC patients and can enhance curative effect of epidermal growth factor receptor tyrosine kinase inhibitor. In this article the progress in the function of estrogen in NSCLC and the treatment based on the ER signaling pathways for NSCLC is reviewed.
authors.affiliation: Cancer Biotherapy Center, the Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.affiliation: Cancer Biotherapy Center, the Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Song
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents; D004967:Estrogens