title: Update on blood pressure control and renal outcomes in diabetes mellitus.
abstract: Diabetic nephropathy (DN) is associated with a high incidence of cardiovascular (CV) morbidity and mortality. Although relationships between hypertension and diabetic nephropathy are complex, blood pressure (BP) control is an important management strategy in the prevention of onset and progression of DN in patients with diabetes mellitus (DM). Recent guidelines recommend less stringent BP targets among patients with type 2 DM and chronic kidney disease. These recommendations are based mostly on lack of benefit in CV outcomes with a low BP target. We review the current information on efficacy of BP control in improving renal outcomes in patients with type 2 DM. Presently, although intensive BP control has been was beneficial in decreasing albuminuria, it has not translated into reductions in risks of hard renal endpoints, such as progression to end-stage renal disease, the need for renal replacement therapy, and mortality from renal causes.
authors.affiliation: Endocrinology, Diabetes and Metabolism, Creighton University, 601 N. 30th Street, Suite 5766, Omaha, NE, 68131, USA, h_joven@yahoo.com.
authors.forename: Mark Henry
authors.initials: MH
authors.lastname: Joven
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Anderson
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000503:physiopathology*; D018450:Disease Progression; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D017410:Practice Guidelines as Topic; D012084:Renin-Angiotensin System