title: Meta-analysis of the IL23R and IL12B polymorphisms in multiple sclerosis.
abstract: OBJECTIVE
  Polymorphisms in the genes encoding interleukin-23 receptor (IL23R) and the p40 subunit of IL-12/23 (IL12B) have been implicated in multiple sclerosis (MS) risk. However, results of different studies are inconsistent. Our aim was to perform a meta-analysis on this topic.
  
  
  METHODS
  We assessed two variants (rs10889677 and rs7517847) of IL23R and the A1188C polymorphism (rs3212227) of IL12B. Electronic databases (PubMed, Web of Science and Scopus) were searched for eligible studies published until September 2014. Odds ratio (OR) and 95% confidence interval (95% CI) were used to investigate the strength of association in dominant, recessive, homozygote and allelic comparison models.
  
  
  RESULTS
  Seven case-control studies with 2250 MS patients and 2320 controls were included in this meta-analysis. The pooled results showed no association of rs10889677 and rs7517847 with MS risk in any of the genetic models. Although the pooled analysis showed an association between rs3212227 and MS in all study subjects in dominant (OR = 0.81, 95% CI: 0.66-0.99, P(h) = 0.480, P(z) = 0.044) and allelic comparison (OR = 0.84, 95% CI: 0.72-0.98, P(h) = 0.967, P(z) = 0.030) models, subgroup analysis based on ethnicity did not suggest an association between rs3212227 and MS risk in Caucasians in any of the genetic models, and there was no association between rs3212227 and MS risk in an Asian group.
  
  
  CONCLUSIONS
  The IL23R polymorphisms rs10889677, rs7517847, and the IL12B polymorphism rs3212227 are not associated with MS risk.
authors.affiliation: a Department of Anatomy and Neurobiology, Zhongshan School of Medicine , Sun Yat-sen University , Guangzhou , China.
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.affiliation: a Department of Anatomy and Neurobiology, Zhongshan School of Medicine , Sun Yat-sen University , Guangzhou , China.
authors.forename: Yaqi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: b Department of Urology, The First Affiliated Hospital , Sun Yat-sen University , Guangzhou , China.
authors.forename: Fengmei
authors.initials: F
authors.lastname: Zhou
authors.affiliation: a Department of Anatomy and Neurobiology, Zhongshan School of Medicine , Sun Yat-sen University , Guangzhou , China.
authors.forename: Zibin
authors.initials: Z
authors.lastname: Liang
authors.affiliation: a Department of Anatomy and Neurobiology, Zhongshan School of Medicine , Sun Yat-sen University , Guangzhou , China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Kang
authors.affiliation: a Department of Anatomy and Neurobiology, Zhongshan School of Medicine , Sun Yat-sen University , Guangzhou , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Kuang
authors.affiliation: a Department of Anatomy and Neurobiology, Zhongshan School of Medicine , Sun Yat-sen University , Guangzhou , China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018123:Receptors, Interleukin / Q000235:genetics*
chemical_list: C515500:IL23R protein, human; D053762:Interleukin-12 Subunit p40; D018123:Receptors, Interleukin
keywords: IL12B; IL23R; meta-analysis; multiple sclerosis; polymorphism