title: Stereochemical evaluation of bis(phosphine) copper catalysts for the asymmetric alkylation of 3-bromooxindoles with α-arylated malonate esters.
abstract: An improved method for the asymetric alkylation of 3-bromooxindoles with α-arylated malonate esters is described. The asymmetric alkylation demonstrated was achieved up to 70% ee utilizing a copper(II) bis(phosphine) complex.
authors.affiliation: Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125, United States.
authors.forename: Chung Whan
authors.initials: CW
authors.lastname: Lee
authors.affiliation: Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125, United States.
authors.forename: Seo-Jung
authors.initials: SJ
authors.lastname: Han
authors.affiliation: Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125, United States.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Virgil
authors.affiliation: Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125, United States.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Stoltz
keywords: 3,3-Disubstituted oxindole; Asymmetric catalysis; Chiral bis(phosphine) ligands; Copper catalysis