title: Understanding the host-pathogen interaction saves lives: lessons from vaccines and vaccinations.
abstract: Vaccines are one of the most successful and cost-effective public health tools employed to date, yet these benefits are only realized when the life-saving intervention reaches each and every targeted individual. Vaccine development is prioritized based on a number of factors such as health burden, feasibility, and determination of potential target populations. But only through an arduous process of pre-clinical development and progressive clinical trials does a vaccine become licensed and recommended for use. Once used in a wider and more diverse population safety issues, long-term impact and other unintended outcomes may become apparent, influencing policy modification. This commentary explores the role host-pathogen interaction plays in vaccine development and the operational and policy considerations that may impact vaccine success post-licensure.
authors.affiliation: Emory University School of Medicine, 1462 Clifton Road, NE, Suite 446, Atlanta, GA 30322, United States.
authors.forename: Julie R
authors.initials: JR
authors.lastname: Garon
authors.affiliation: Emory University School of Medicine, 1462 Clifton Road, NE, Suite 446, Atlanta, GA 30322, United States. Electronic address: worenst@emory.edu.
authors.forename: Walter A
authors.initials: WA
authors.lastname: Orenstein
mesh_terms: D000818:Animals; D003140:Communicable Disease Control / Q000191:economics / Q000331:legislation & jurisprudence / Q000379:methods; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D014611:Vaccination / Q000009:adverse effects / Q000191:economics / Q000331:legislation & jurisprudence / Q000379:methods; D014612:Vaccines / Q000009:adverse effects / Q000276:immunology*
chemical_list: D014612:Vaccines