title: Study of multi-functional electrospun composite nanofibrous mats for smart wound healing.
abstract: Composite nanofibers derived from synthetic and natural polymers normally show desirable characteristics in biomedical applications. In this study, composite nanofibrous mats (denoted as CNMs) with diameters of around 300 nm were fabricated facilely using blends of chitosan, gelatin and shape memory polyurethane (SMPU) by electrospinning and subsequent post-treatment with a silver nitrate solution. The obtained CNMs have shape memory effect and show desirable water vapor transmission ratio, surface wettability, satisfactory biological properties including antibacterial activity against the common Gram-negative and Gram-positive bacteria, cytocompatibility demonstrated to fibroblast, and the hemostatic property through a whole-blood clotting test. In addition, such CNMs can possibly benefit the wound healing through shape fixation-assisted easy processing and shape recovery-assisted closure of cracked wounds, which can be fine-tuned by pre-programming. Therefore, the CNMs presented in this study can be used as potential smart wound dressings.
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Tan
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China; PolyU Shenzhen Base, Nanshan District, Shenzhen, China. Electronic address: tchujl@polyu.edu.hk.
authors.forename: Jinlian
authors.initials: J
authors.lastname: Hu
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Huahua
authors.initials: H
authors.lastname: Huang
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Han
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Huawen
authors.initials: H
authors.lastname: Hu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001458:Bandages; D001777:Blood Coagulation / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry*; D052978:Disk Diffusion Antimicrobial Tests; D055664:Electrochemical Techniques; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005780:Gelatin / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D051379:Mice; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D011140:Polyurethanes / Q000737:chemistry*; D012835:Silver Nitrate / Q000737:chemistry / Q000494:pharmacology*; D013227:Steam / Q000032:analysis; D017155:Wettability; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D011140:Polyurethanes; D013227:Steam; D005780:Gelatin; D048271:Chitosan; D012835:Silver Nitrate
keywords: Composites; Multi-functional; Nanofibrous structure; Wound dressing