title: Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology.
abstract: Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror the phenotypes and functions of T cells. However, in contrast to T cells, ILCs do not express acquired antigen receptors or undergo clonal selection and expansion when stimulated. Instead, ILCs react promptly to signals from infected or injured tissues and produce an array of secreted proteins termed cytokines that direct the developing immune response into one that is adapted to the original insult. The complex cross-talk between microenvironment, ILCs, and adaptive immunity remains to be fully deciphered. Only by understanding these complex regulatory networks can the power of ILCs be controlled or unleashed in order to regulate or enhance immune responses in disease prevention and therapy.
authors.affiliation: Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France. gerard.eberl@pasteur.fr.
authors.forename: Gérard
authors.initials: G
authors.lastname: Eberl
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Colonna
authors.affiliation: Institut Pasteur, Innate Immunity Unit, INSERM U668, 75724 Paris, France.
authors.forename: James P
authors.initials: JP
authors.lastname: Di Santo
authors.affiliation: Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
authors.forename: Andrew N J
authors.initials: AN
authors.lastname: McKenzie
mesh_terms: D056704:Adaptive Immunity; D000273:Adipose Tissue / Q000276:immunology; D005075:Biological Evolution; D001853:Bone Marrow / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D004032:Diet; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy; D007249:Inflammation / Q000276:immunology; D008099:Liver / Q000196:embryology / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D064307:Microbiota / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D016207:Cytokines