title: Selective Serotonin Reuptake Inhibitors (SSRIs) and the Risk of Congenital Heart Defects: A Meta-Analysis of Prospective Cohort Studies.
abstract: BACKGROUND
  Recent studies have reported conflicting results on the association between selective serotonin reuptake inhibitors (SSRIs) and the risk of heart defects. We aimed to assess the association between SSRIs in pregnant women during the first trimester and the risk of congenital heart defects.
  
  
  RESULTS
  PubMed and EMBASE up to July 2014 were searched for population-based cohort studies that reported SSRIs in pregnant women during the first trimester and live infants' heart defects at follow-up. A meta-analysis of published data was undertaken primarily by means of fixed-effects models. Four cohort studies including 1 996 519 participants were included with a mean follow-up period ranging from discharge to 72 months. SSRIs were not associated with increased risks of heart defects 1.06 (95% confidence interval: 0.94 to 1.18).
  
  
  CONCLUSIONS
  SSRIs during the first trimester in pregnant women were not associated with increased risks for newborn heart defects.
authors.affiliation: Department of Cardiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China (S.W., L.W., L.G., B.X.).
authors.forename: Shang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China (L.Y.).
authors.forename: Lijuan
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China (S.W., L.W., L.G., B.X.).
authors.forename: Lian
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China (S.W., L.W., L.G., B.X.).
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Cardiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China (S.W., L.W., L.G., B.X.).
authors.forename: Biao
authors.initials: B
authors.lastname: Xu
authors.affiliation: Department of Ultrasound, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China (Y.X.).
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D011261:Pregnancy Trimester, First / Q000187:drug effects*; D011446:Prospective Studies; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors
keywords: SSRIs; antidepressant; congenital; heart defects; meta‐analysis; pregnant