title: A new WNT on the bone: WNT16, cortical bone thickness, porosity and fractures.
abstract: The last decade has provided abundant data implicating the WNT pathway in bone development and in the regulation of skeletal homeostasis. Rare human mutations together with gain- and loss-of-function approaches in mice have clearly demonstrated that disrupted regulation of this pathway leads to altered bone mass. In addition to these rare human and mice mutations, large population-based genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms in ∼60 loci strongly associated with variations in bone mineral density (BMD) at different skeletal sites. Among the loci/genes identified by BMD GWAS, components of the WNT signaling pathway are numerous and have been shown to contribute to skeletal development and homeostasis. Within the components of WNT signaling, the gene coding for WNT16, one of the 19 WNT ligands of the human genome, has been found strongly associated with specific bone traits such as cortical bone thickness, cortical porosity and fracture risk. Recently, the first functional characterization of Wnt16 has confirmed the critical role of Wnt16 in the regulation of cortical bone mass and bone strength in mice. These reports have extended our understanding of Wnt16 function in bone homeostasis and have not only confirmed the unique association of Wnt16 with cortical bone and fracture susceptibility, as suggested by GWAS in human populations, but have also provided novel insights into the biology of this WNT ligand and the mechanism(s) by which it regulates cortical but not trabecular bone homeostasis. Most interestingly, Wnt16 appears to be a strong anti-resorptive soluble factor acting on both osteoblasts and osteoclast precursors.
authors.affiliation: Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine , Boston, MA, USA.
authors.forename: Francesca
authors.initials: F
authors.lastname: Gori
authors.affiliation: Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg , Gothenburg, Sweden ; Molecular Periodontology, Umea University , Umea, Sweden.
authors.forename: Ulf
authors.initials: U
authors.lastname: Lerner
authors.affiliation: Centre for Bone and Arthritis Research at Institute of Medicine, Sahlgrenska Academy at University of Gothenburg , Gothenburg, Sweden.
authors.forename: Claes
authors.initials: C
authors.lastname: Ohlsson
authors.affiliation: Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine , Boston, MA, USA ; Department of Medicine, Endocrine Unit, Massachusetts General Hospital, Harvard Medical School , Boston, MA, USA.
authors.forename: Roland
authors.initials: R
authors.lastname: Baron