title: Ovarian hyperstimulation syndrome after gonadotropin-releasing hormone agonist triggering and "freeze-all": in-depth analysis of genetic predisposition.
abstract: OBJECTIVE
  We report on the results of the whole-genome analysis performed in a patient who developed severe ovarian hyperstimulation syndrome (OHSS) following gonadotropin-releasing hormone (GnRH) agonist triggering in a "freeze-all" protocol.
  
  
  METHODS
  A 30-year-old patient with polycystic ovary syndrome who developed severe early-onset OHSS with clinical ascites, and slight renal and hepatic dysfunction was admitted for monitoring and treatment with cabergoline and intravenous albumin. Exome sequencing to assess for any known genetic predisposition for OHSS was performed.
  
  
  RESULTS
  No known genetic variants associated with OHSS predisposition were found.
  
  
  CONCLUSIONS
  Case reports of severe OHSS following a "freeze-all" strategy are starting to arise, showing that OHSS has not been completely eliminated with this approach. Further studies should be conducted to confirm if such cases may be due to genetic predisposition or not.
authors.affiliation: Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.
authors.forename: Samuel
authors.initials: S
authors.lastname: Santos-Ribeiro
authors.forename: Nikolaos P
authors.initials: NP
authors.lastname: Polyzos
authors.forename: Katrien
authors.initials: K
authors.lastname: Stouffs
authors.forename: Michel
authors.initials: M
authors.lastname: De Vos
authors.forename: Sara
authors.initials: S
authors.lastname: Seneca
authors.forename: Herman
authors.initials: H
authors.lastname: Tournaye
authors.forename: Christophe
authors.initials: C
authors.lastname: Blockeel
mesh_terms: D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D008297:Male; D054315:Oocyte Retrieval; D016471:Ovarian Hyperstimulation Syndrome / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D007987:Gonadotropin-Releasing Hormone