title: [Genome wide expression analysis of the effect of Socheongryong Tang in asthma model of mice].
abstract: OBJECTIVE
  To investigate the molecular effect of Socheongryong Tang (SCRT, Xiaoqinglong Tang in Chinese) on whole genome level in asthma mouse model by microarray technology.
  
  
  METHODS
  Asthma was induced by intranasal instillation of ovalbumin in mouse. After administration of SCRT on asthma-induced mouse, the expression of genes in lung tissue was measured using whole genome microarray. The functional implication of differentially expressed genes was performed using ontological analysis and the similarity of promoter structure of genes was also analyzed.
  
  
  RESULTS
  Treatment of SCRT restored expression level of many up- or down-regulated genes in asth- ma model, and this recovery rate means SCRT could regulate a set of genes having specific TFBS binding sites.
  
  
  CONCLUSIONS
  In this study, we identified a set of genes subjected to similar regulation by SCRT in asthma model in mice.
authors.forename: Chi-Yeon
authors.initials: CY
authors.lastname: Lim
authors.forename: Hyung-Woo
authors.initials: HW
authors.lastname: Kim
authors.forename: Bu-Yeo
authors.initials: BY
authors.lastname: Kim
authors.forename: Su-In
authors.initials: SI
authors.lastname: Cho
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D016678:Genome / Q000187:drug effects*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D011506:Proteins / Q000235:genetics
chemical_list: D004365:Drugs, Chinese Herbal; D011506:Proteins