title: Krüppel-ling of IRF4-Dependent DCs into Two Functionally Distinct DC Subsets.
abstract: IRF4-dependent DCs have been associated with induction of both Th1 and Th17 cells. In this issue of Immunity, Tussiwand et al. (2015) demonstrate that a dependence on KLF4 identifies a subset of IRF4-dependent DC that preferentially promotes Th2 cell differentiation.
authors.affiliation: Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, The University of Melbourne, 3000 VIC, Australia. Electronic address: sbedoui@unimelb.edu.au.
authors.forename: Sammy
authors.initials: S
authors.lastname: Bedoui
authors.affiliation: Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, The University of Melbourne, 3000 VIC, Australia.
authors.forename: William R
authors.initials: WR
authors.lastname: Heath
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000276:immunology*; D051741:Kruppel-Like Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D012555:Schistosomiasis mansoni / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D051741:Kruppel-Like Transcription Factors