title: New insights into HLA class I association to Behçet's syndrome in Iranian Azari patients.
abstract: Behçet's syndrome (BS) is a chronic recurrent inflammatory disorder characterized by oral and genital ulcers and ocular inflammation. BS has a complex genetic etiology. To evaluate the influence of human leukocyte antigen (HLA) class I in BS susceptibility in Iranian Azari population, we studied 290 BS patients and 300 healthy controls. As expected, a high frequency of HLA-B5 was found. Remarkably, HLA-B35 frequency was higher in the patient than control group, and the frequency of HLA-B51, HLA-B52, and HLA-BW4 was significantly elevated. Thus, HLA-B5 and HLA-B35 seem to confer susceptibility to BD in Iranian Azari patients.
authors.affiliation: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Fatemeh Zare
authors.initials: FZ
authors.lastname: Shahneh
authors.affiliation: Imam Reza Medical Research and Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Hamzavi
authors.affiliation: Imam Reza Medical Research and Training Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Babak
authors.initials: B
authors.lastname: Bayazi
authors.affiliation: Plant Breeding and Biotechnology Department, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Bandehagh
authors.affiliation: Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Immunology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Baradaran
keywords: Behçet’s syndrome; HLA antigens; HLA typing