title: Clinical characteristics of narrow-band imaging of oral erythroplakia and its correlation with pathology.
abstract: BACKGROUND
  To analyze the clinical application of endoscope with narrow-band imaging (NBI) system in detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral erythroplakia.
  
  
  METHODS
  The demographic, histopathological data, and NBI vasculature architectures of patients receiving surgical intervention for oral erythroplakia were retrospectively reviewed and analyzed statistically.
  
  
  RESULTS
  A total of 72 patients, including 66 males and 6 females, with mean age of 54.6 ± 11.2 years, were enrolled. The odds ratio of detecting high-grade dysplasia, carcinoma in situ, and carcinoma by twisted elongated morphology and destructive pattern of intraepithelial microvasculature was 15.46 (confidence interval 95%: 3.81-72.84), and the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 80.95%, 78.43%, 60.71%, 90.91%, and 79.17%, respectively, which were significantly better than other two established NBI criteria (p < 0.001).
  
  
  CONCLUSIONS
  Twisted, elongated, and destructive patterns of intraepithelial papillary capillary loop of NBI images are indicators for high-grade dysplasia, carcinoma in situ, and invasive carcinoma in oral erythroplakia.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung; No. 222, Mai Chin Road, Keelung, 204, Taiwan. sweeyang@gmail.com.|School of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan. sweeyang@gmail.com.
authors.forename: Shih-Wei
authors.initials: SW
authors.lastname: Yang
authors.affiliation: Genomic Medicine Research Core Laboratory, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan. bojack@mail.mcu.edu.tw.|Department of Biotechnology, Ming Chuan University, Tao-Yuan, Taiwan. bojack@mail.mcu.edu.tw.
authors.forename: Yun-Shien
authors.initials: YS
authors.lastname: Lee
authors.affiliation: School of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan. lc2008@cgmh.org.tw.|Department of Pathology, Chang Gung Memorial Hospital, Keelung, Taiwan. lc2008@cgmh.org.tw.
authors.forename: Liang-Che
authors.initials: LC
authors.lastname: Chang
authors.affiliation: School of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan. rrooyyaa@cgmh.org.tw.|Department of Pathology, Chang Gung Memorial Hospital, Keelung, Taiwan. rrooyyaa@cgmh.org.tw.
authors.forename: Cheng-Cheng
authors.initials: CC
authors.lastname: Hwang
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung; No. 222, Mai Chin Road, Keelung, 204, Taiwan. lcm3647@gmail.com.|School of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan. lcm3647@gmail.com.
authors.forename: Cheng-Ming
authors.initials: CM
authors.lastname: Luo
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung; No. 222, Mai Chin Road, Keelung, 204, Taiwan. anmaka@ms15.hinet.net.|School of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan. anmaka@ms15.hinet.net.
authors.forename: Tai-An
authors.initials: TA
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D004919:Erythroplasia / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology*; D062048:Narrow Band Imaging; D012189:Retrospective Studies