title: A systemic review of randomized controlled studies about prevention with pharmacologic agents of adhesion formation in the rat uterine horn model.
abstract: BACKGROUND
  Evaluation of treatment attempts in postoperative adhesion formation is pivotal for the prevention of several morbidities including infertility, pelvic pain, bowel obstruction, and subsequent intraoperative complications. The purpose of this systemic review was to assess the literature on the rat uterine horn model for adhesion formation and treatment modalities to prevent adhesion in the most frequently used experimental animal model.
  
  
  METHODS
  We performed a systemic review of publications from January 1(st) 2000 to December 31(st) 2013 via a PubMed search. A high number of agents were evaluated for the prevention of postoperative adhesion formation in the rat uterine horn model.
  
  
  RESULTS
  According to most of the studies, adjuvants such as antiinflamatuars, antiestrogens, antioxidants were effective to prevent adhesion formation.
  
  
  CONCLUSIONS
  Prevention of adhesion formation is pivotal and numerous types of agents were described in the literature were summarized in this review.
authors.affiliation: Department of Obstetric and Gynecology, Mugla Sitki Kocman University, Mugla, Turkey.
authors.forename: Gokalp
authors.initials: G
authors.lastname: Oner
authors.affiliation: Department of Obstetric and Gynecology, Erzincan University, Erzincan, Turkey.
authors.forename: Pasa
authors.initials: P
authors.lastname: Ulug
keywords: adhesion; prevention; rat; systemic review; uterine horn