title: Assessment of human sinus cavity air volume using tunable diode laser spectroscopy, with application to sinusitis diagnostics.
abstract: Sinusitis is a very common disease and improved diagnostic tools are desirable also in view of reducing over-prescription of antibiotics. A non-intrusive optical technique called GASMAS (GAs in Scattering Media Absorption Spectroscopy), which has a true potential of being developed into an important complement to other means of detection, was utilized in this work. Water vapor in the frontal sinuses, related to the free gas volume, was studied at around 937 nm in healthy volunteers. The results show a good stability of the GASMAS signals over extended times for the frontal sinuses for all volunteers, showing promising applicability to detect anomalies due to sinusitis. Measurements were also performed following the application of a decongestion spray. No noticeable signal change was observed, which is consistent with the fact that the water vapor concentration is given by the temperature only, and is not influenced by changes in cavity ventilation. Evaluated GASMAS data recorded on 6 consecutive days show signal stability for the left and right frontal sinus in one of the test volunteers.
authors.affiliation: Center for Optics and Electromagnetic Research, South China Normal University, University City Campus, Guangzhou, 510006, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Center for Optics and Electromagnetic Research, South China Normal University, University City Campus, Guangzhou, 510006, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Center for Optics and Electromagnetic Research, South China Normal University, University City Campus, Guangzhou, 510006, China.
authors.forename: Tianqi
authors.initials: T
authors.lastname: Li
authors.affiliation: Center for Optics and Electromagnetic Research, South China Normal University, University City Campus, Guangzhou, 510006, China.
authors.forename: Huiying
authors.initials: H
authors.lastname: Lin
authors.affiliation: Center for Optics and Electromagnetic Research, South China Normal University, University City Campus, Guangzhou, 510006, China.|Lund Laser Center, Lund University, SE-221 00, Lund, Sweden.
authors.forename: Katarina
authors.initials: K
authors.lastname: Svanberg
authors.affiliation: Center for Optics and Electromagnetic Research, South China Normal University, University City Campus, Guangzhou, 510006, China. sune.svanberg@fysik.lth.se.|Lund Laser Center, Lund University, SE-221 00, Lund, Sweden. sune.svanberg@fysik.lth.se.
authors.forename: Sune
authors.initials: S
authors.lastname: Svanberg
mesh_terms: D004867:Equipment Design; D005260:Female; D005626:Frontal Sinus / Q000033:anatomy & histology* / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007834:Lasers; D008297:Male; D014663:Nasal Decongestants / Q000008:administration & dosage; D061848:Optical Imaging / Q000295:instrumentation / Q000379:methods*; D009929:Organ Size; D015203:Reproducibility of Results; D012852:Sinusitis / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods*; D013227:Steam; D013696:Temperature
chemical_list: D014663:Nasal Decongestants; D013227:Steam
keywords: GASMAS; antibiotic resistance; frontal sinus; paranasal cavities; sinusitis; water vapor