title: Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria.
abstract: The impact of complement activation and its possible relation to cytokine responses during malaria pathology was investigated in plasma samples from patients with confirmed Plasmodium falciparum malaria and in human whole-blood specimens stimulated with malaria-relevant agents ex vivo. Complement was significantly activated in the malaria cohort, compared with healthy controls, and was positively correlated with disease severity and with certain cytokines, in particular interleukin 8 (IL-8)/CXCL8. This was confirmed in ex vivo-stimulated blood specimens, in which complement inhibition significantly reduced IL-8/CXCL8 release. P. falciparum malaria is associated with systemic complement activation and complement-dependent release of inflammatory cytokines, of which IL-8/CXCL8 is particularly prominent.
authors.affiliation: Department of Medicine, Stavanger University Hospital Department of Clinical Science, University of Bergen Department of Medicine, Central Hospital of Maputo, Mozambique.
authors.forename: Aase
authors.initials: A
authors.lastname: Berg
authors.affiliation: Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet.
authors.forename: Kari
authors.initials: K
authors.lastname: Otterdal
authors.affiliation: Department of Medicine, Central Hospital of Maputo, Mozambique.
authors.forename: Sam
authors.initials: S
authors.lastname: Patel
authors.affiliation: Department of Medicine, Central Hospital of Maputo, Mozambique.
authors.forename: Miguel
authors.initials: M
authors.lastname: Gonca
authors.affiliation: Department of Medicine, Central Hospital of Maputo, Mozambique.
authors.forename: Catarina
authors.initials: C
authors.lastname: David
authors.affiliation: Department of Research, Stavanger University Hospital.
authors.forename: Ingvild
authors.initials: I
authors.lastname: Dalen
authors.affiliation: Department of Immunology, Oslo University Hospital Rikshospitalet Research Laboratory Nordland Hospital, Bodø Faculty of Health Sciences, University of Tromsø, Norway.
authors.forename: Stig
authors.initials: S
authors.lastname: Nymo
authors.affiliation: Department of Immunology, Oslo University Hospital Rikshospitalet.
authors.forename: Margareta
authors.initials: M
authors.lastname: Nilsson
authors.affiliation: Department of Immunology, Genetics, and Pathology, the Rudbeck Laboratory, Uppsala University, Sweden.
authors.forename: Sofia
authors.initials: S
authors.lastname: Nordling
authors.affiliation: Department of Immunology, Genetics, and Pathology, the Rudbeck Laboratory, Uppsala University, Sweden.
authors.forename: Peetra U
authors.initials: PU
authors.lastname: Magnusson
authors.affiliation: Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet K. G. Jebsen Inflammatory Research Center, University of Oslo Faculty of Medicine, University of Oslo K.G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Norway.
authors.forename: Thor
authors.initials: T
authors.lastname: Ueland
authors.affiliation: Department of Neuroscience, University of Torino, Italy Department of Public Health and Pediatric Sciences, University of Torino, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Prato
authors.affiliation: Department of Oncology, University of Torino, Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Giribaldi
authors.affiliation: Department of Immunology, Oslo University Hospital Rikshospitalet K. G. Jebsen Inflammatory Research Center, University of Oslo Faculty of Medicine, University of Oslo Research Laboratory Nordland Hospital, Bodø Faculty of Health Sciences, University of Tromsø, Norway.
authors.forename: Tom Eirik
authors.initials: TE
authors.lastname: Mollnes
authors.affiliation: Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet K. G. Jebsen Inflammatory Research Center, University of Oslo Faculty of Medicine, University of Oslo.
authors.forename: Pål
authors.initials: P
authors.lastname: Aukrust
authors.affiliation: Department of Clinical Science, University of Bergen Department of Medicine, Haukeland University Hospital, Bergen.
authors.forename: Nina
authors.initials: N
authors.lastname: Langeland
authors.affiliation: Department of Immunology, Oslo University Hospital Rikshospitalet.
authors.forename: Per H
authors.initials: PH
authors.lastname: Nilsson
mesh_terms: D000328:Adult; D003167:Complement Activation / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism*; D006420:Hemeproteins / Q000276:immunology; D006427:Hemin / Q000276:immunology; D006801:Humans; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000276:immunology* / Q000378:metabolism* / Q000503:physiopathology; D010963:Plasmodium falciparum / Q000276:immunology
chemical_list: D016207:Cytokines; D006420:Hemeproteins; C020753:hemozoin; D006427:Hemin
keywords: C5a/C5aR1; IL-8/CXCL8; Plasmodium falciparum; complement activation; cytokines; heme; hemozoin; inflammation; malaria