title: Evidences of hepatoprotective and antioxidant effect of Citrullus colocynthis fruits in paracetamol induced hepatotoxicity.
abstract: The objective of present study was to explore the hepatoprotective and antioxidant profile of Citrullus colocynthis fruits. Hepatoprotective profile of methanolic extract of Citrullus colocynthis fruits (MECCF) was investigated on rats, which were made hepatotoxic using paracetamol. The antioxidant profile of MECCF was evaluated by conducting Catalase, Super oxide Dismutase, Lipid Peroxidation and Diphenyl Picryl Hydrazyl tests. During hepatoprotective investigation, the Paracetamol treated group II showed significant increase in total bilirubin (TB), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) level. The results so obtained showed that pretreatment of rats with MECCF 300mg/kg p.o. decreases the elevated TB, SGOT, SGPT and ALP serum levels. Also, MECCF inhibitory profile was found comparable with toxicant group (Paracetamol 2g/kg, p.o.). The present study concludes that MECCF fruit possess significant hepatoprotective and antioxidant activity.
authors.affiliation: Anuradha College of Pharmacy (University of Amravati), Anuradha Nagar, Chikhli, Dist. Buldana (M.S.), India.
authors.forename: Syed
authors.initials: S
authors.lastname: Vakiloddin
authors.affiliation: Faculty of Pharmacy, AIMST University, Semeling Campus, Jalan Bedong-Semeling, Bedong, Kedah Darul Aman, Malaysia.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Fuloria
authors.affiliation: Faculty of Pharmacy, AIMST University, Semeling Campus, Jalan Bedong-Semeling, Bedong, Kedah Darul Aman, Malaysia.
authors.forename: Shivkanya
authors.initials: S
authors.lastname: Fuloria
authors.affiliation: Faculty of Pharmacy, AIMST University, Semeling Campus, Jalan Bedong-Semeling, Bedong, Kedah Darul Aman, Malaysia.
authors.forename: Sokkalingam Arumugam
authors.initials: SA
authors.lastname: Dhanaraj
authors.affiliation: Faculty of Pharmacy, AIMST University, Semeling Campus, Jalan Bedong-Semeling, Bedong, Kedah Darul Aman, Malaysia.
authors.forename: Kaveti
authors.initials: K
authors.lastname: Balaji
authors.affiliation: Faculty of Pharmacy, AIMST University, Semeling Campus, Jalan Bedong-Semeling, Bedong, Kedah Darul Aman, Malaysia.
authors.forename: Sundram
authors.initials: S
authors.lastname: Karupiah
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D065986:Citrullus colocynthis; D005638:Fruit; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats
chemical_list: D018712:Analgesics, Non-Narcotic; D000975:Antioxidants; D010936:Plant Extracts; D020011:Protective Agents; D000082:Acetaminophen