title: [Association of cytokine gene polymorphisms in peptic ulcer development in the Bashkortostan Republic].
abstract: Peptic ulcer disease (PUD) is a chronic disease based on recurrent gastric or duodenal ulcers. Association analysis of common polymorphisms of the cytokines genes IL1B (rs1143634), IL1RN (rs71941886), IL8 (rs4073), IL10 (rs1800872), and TNFA (rs1800629) was conducted in 254 patients with gastric ulcer or duodenal ulcer and in 277 unrelated healthy individuals from the Bashkortostan Republic. Associations of the rs1143634C allele and the C/C genotype of the IL1B gene with PUD in ethnic Bashkirs have been revealed. The frequency of the rs4073A/A genotype of the IL8 gene was significantly higher in the control group as compared to patients infected with H. pylori. Our results confirm the significant role of rs1143634 of the IL1B gene in PUD development.
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Nurgalieva
authors.forename: E Kh
authors.initials: EKh
authors.lastname: Shaymardanova
authors.forename: I M
authors.initials: IM
authors.lastname: Khidiyatova
authors.forename: D D
authors.initials: DD
authors.lastname: Nadyrshina
authors.forename: L V
authors.initials: LV
authors.lastname: Gabbasova
authors.forename: O A
authors.initials: OA
authors.lastname: Kuramshina
authors.forename: A Ya
authors.initials: AY
authors.lastname: Krukova
authors.forename: E K
authors.initials: EK
authors.lastname: Khusnutdinova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001486:Bashkiria; D016207:Cytokines / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000235:genetics / Q000473:pathology; D016480:Helicobacter pylori / Q000235:genetics; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D016207:Cytokines; C508585:IL1B protein, human; D053583:Interleukin-1beta