title: Therapeutic antibodies: Discovery, design and deployment.
abstract: Therapeutic antibodies have come of age with major progress being made in cancer, autoimmunity and chronic inflammation, as well as a wide range of other human diseases. Antibody engineering is further driving development of novel antibody formats and genetically modified cell-based therapies that harness the power of the immune system to progress cures in otherwise intractable human diseases. Nevertheless, there are still significant challenges ahead for basic and applied research relating to therapeutic antibodies. This special issue of the journal provides reviews and opinions that relate to the discovery, design and deployment of antibodies as therapeutics.
authors.affiliation: Centre for Biomedical Research, Burnet Institute, Melbourne, VIC 3004, Australia; Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, VIC 3004, Australia; Department of Surgery Austin Health, University of Melbourne, Heidelberg, VIC 3084, Australia; School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, WA 6845, Australia. Electronic address: pramsland@burnet.edu.au.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Ramsland
authors.affiliation: Centre for Biomedical Research, Burnet Institute, Melbourne, VIC 3004, Australia; School of Life Sciences, Centre for Health Technologies, University of Technology Sydney, Ultimo, NSW 2007, Australia; Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA.
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Hutchinson
authors.affiliation: Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Carter
mesh_terms: D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000276:immunology / Q000627:therapeutic use; D015195:Drug Design; D055808:Drug Discovery; D006801:Humans; D007167:Immunotherapy / Q000379:methods* / Q000639:trends; D058990:Molecular Targeted Therapy / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D000970:Antineoplastic Agents