title: Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei.
abstract: Antigenic variation is central to the virulence of African trypanosomes, where the VSG coat is used to evade the host immune system. Recent advances in technology have now allowed more secrets of this system to emerge, with the surprising insight that a broad repertoire of VSGs is rapidly expressed. This has major implications for how the parasite must evade the host immune response.
authors.affiliation: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: McCulloch
authors.affiliation: Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, DD1 5EH, UK. Electronic address: mfield@mac.com.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Field
mesh_terms: D000940:Antigenic Variation / Q000235:genetics / Q000276:immunology; D006790:Host-Parasite Interactions / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion / Q000235:genetics / Q000276:immunology; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000276:immunology; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000235:genetics / Q000276:immunology
chemical_list: D014643:Variant Surface Glycoproteins, Trypanosoma
keywords: Trypanosoma brucei; VSG; antigenic variation; immune evasion; recombination