title: Stereotactic radiation therapy combined with immunotherapy: augmenting the role of radiation in local and systemic treatment.
abstract: Stereotactic radiosurgery and stereotactic body radiation therapy are two contemporary radiation modalities that can treat tumors in any area of the body using highly focused radiation. Recently, immunotherapy has established itself as a viable and powerful anticancer treatment. In this review we detail the rationale supporting a combination of immunotherapy and stereotactic radiation. Additionally, we discuss the evidence for the immune stimulatory effects of focused radiation and the role that radiation may play in enhancing the systemic treatment effects of immunotherapy.
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Sharabi
authors.forename: Phuoc T
authors.initials: PT
authors.lastname: Tran
authors.forename: Michael
authors.initials: M
authors.lastname: Lim
authors.forename: Charles G
authors.initials: CG
authors.lastname: Drake
authors.forename: Theodore L
authors.initials: TL
authors.lastname: Deweese
mesh_terms: D003131:Combined Modality Therapy; D005910:Glioma / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D008175:Lung Neoplasms / Q000628:therapy; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D011471:Prostatic Neoplasms / Q000628:therapy; D016634:Radiosurgery