title: The role of CGRP and CALCA T-692C single-nucleotide polymorphism in psoriasis vulgaris.
abstract: Calcitonin gene related protein (CGRP) is increased in both lesional and non-lesional psoriasis. The role of CGRP in the pathogenesis of psoriasis vulgaris is still not clear. We designed to determine the CGRP-I (or CALCA), II (or CALCB) gene expression and morbidity and CALCA T-692C single-nucleotide polymorphism (SNP). Peripheral blood mononuclear cells (PBMCs) and plasma samples were collected, and CGRP level and CGRP-I, II mRNA expression were measured in psoriasis patients and healthy controls. The CALCA T-692C genetic polymorphism in psoriasis and control subjects was also compared. A higher expression of CGRP-I, II mRNA in PBMCs in psoriasis patients. The plasma CGRP level in psoriasis patients was also higher than that in healthy subjects. SNP analysis showed carriers of the T-692C allele were over-represented in non-drinking Patients. The plasma CGRP level was higher in alcohol-drinking patients with TT genotype than that with TC genotype. The plasma CGRP level is increased in psoriasis patients and CALCA T-692C polymorphism TT genotype is a factor for the affectability in alcohol-drinking Psoriasis vulgaris patients.
authors.forename: Ren
authors.initials: R
authors.lastname: Guo
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Li
authors.forename: Ming-Liang
authors.initials: ML
authors.lastname: Chen
authors.forename: Ming-Zhu
authors.initials: MZ
authors.lastname: Ya
authors.forename: Hui-Lan
authors.initials: HL
authors.lastname: He
authors.forename: Dai
authors.initials: D
authors.lastname: Li
mesh_terms: D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking / Q000009:adverse effects / Q000235:genetics; D000818:Animals; D002116:Calcitonin / Q000097:blood / Q000235:genetics*; D015740:Calcitonin Gene-Related Peptide / Q000097:blood / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011498:Protein Precursors / Q000097:blood / Q000235:genetics*; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D012306:Risk; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: C000606589:CALCA protein, human; C000606591:Calca protein, rat; D011498:Protein Precursors; D012333:RNA, Messenger; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide