title: Ruthenium-catalyzed oxidative coupling of 2-aryl-4-quinazolinones with olefins: synthesis of pyrrolo[2,1-b]quinazolin-9(1H)-one motifs.
abstract: A ruthenium-catalyzed oxidative coupling of 2-aryl-quinazolinones with olefins via C-H bond activation followed by an intramolecular aza-Michael reaction is described. This strategy allows the direct and efficient construction of pyrrolo[2,1-b]quinazolin-9(1H)-one scaffolds.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China. ljxuan@mail.shcnc.ac.cn.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zheng
authors.forename: Wei-Bin
authors.initials: WB
authors.lastname: Song
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Zhang
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Xuan
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D058451:Oxidative Coupling; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D052999:Quinazolinones; D012428:Ruthenium