title: Mixed mucoepidermoid carcinoma and adenocarcinoma of the lung: Two cases with unusual histologic features.
abstract: We herein report two cases of non-small cell lung cancer with unusual histologic patterns, comprising mixed mucoepidermoid carcinoma and adenocarcinoma. Both cases presented identical genetic mutations in each histologic component of the tumor; specifically, one case possessed an ALK-rearrangement and the other case presented a deletion in exon 19 of the EGFR gene. The two current cases, as well as an additional case that we previously reported, were all identified as being a specific type of mixed lung cancer with driver mutations typically encountered in conventional lung adenocarcinomas. Our findings support the supposition that different histological components in mixed-histology lung cancer are clonally related. Accordingly, extensive tissue sampling is necessary to avoid overlooking minor adenocarcinomatous components, as patients with mixed lung cancer could potentially benefit from treatment with tyrosine kinase inhibitors.
authors.affiliation: Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Min-Shu
authors.initials: MS
authors.lastname: Hsieh
authors.affiliation: Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Yi-Hsuan
authors.initials: YH
authors.lastname: Lee
authors.affiliation: Department of Thoracic Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Jin-Shing
authors.initials: JS
authors.lastname: Chen
authors.affiliation: Department of Thoracic Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Jang-Ming
authors.initials: JM
authors.lastname: Lee
authors.affiliation: Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: ntuhylc@gmail.com.
authors.forename: Yih-Leong
authors.initials: YL
authors.lastname: Chang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*
keywords: ALK; Adenocarcinoma; Driver mutation; EGFR; Mixed lung cancer; Mucoepidermoid carcinoma