title: Glutathione-S-Transferase Deletions and Non-arteritic Anterior Ischemic Optic Neuropathy.
abstract: In this study, we aimed at investigating the association between glutathione-S-transferase (GSTM1 and GSTT1) deletion genotypes and susceptibility to non-arteritic anterior ischemic optic neuropathy (NAION). We hope our findings may contribute to the understanding NAION pathogenesis and provide some clues for the prevention and treatment of optic diseases. The NAION group contains 113 subjects (33 males and 80 females, mean age 55.3 ± 9.8). And 98 subjects were enrolled in the control group (32 males and 66 females, mean age 56.7 ± 10.2). The individuals involved in the study were matched by gender and age to obtain two homogenous groups. GSTM1- and GSTT1- genotype and the combined genotype were investigated. The genotype distributions in NAION patients were compared with those in the controls. Significantly altered intraocular pressure (IOP) and cup-to-disc ratio (CDR) was detected between NAION patients and controls. An increased risk of NAION was observed among individuals with GSTM1- (P < 0.001). No significant difference was confirmed for GSTT1- (P = 0.290). Individuals with GSTM1-/GSTT1- have a higher susceptibility to NAION (P < 0.001); the GSTM1-/GSTT1+ genotype also had a significantly higher frequency in patients than in controls (P = 0.004). But the genotype of GSTM1+/GSTT1- seems to have no connection with NAION (P = 0.476). In conclusion, in this study, we confirmed the connection between NAION and GSTM1- genotype. But no significant association was observed between GSTT1- genotype and NAION susceptibility. In further analysis regarding combined genotype, a trend of protective effect was detected for GSTT1+ genotype. It is indicated by our result that oxidative compounds might play an important part in the pathogenesis of NAION.
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 East-Jianshe Road, Zhengzhou, 450052, China.
authors.forename: Wencui
authors.initials: W
authors.lastname: Wan
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 East-Jianshe Road, Zhengzhou, 450052, China.
authors.forename: Xuemin
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 East-Jianshe Road, Zhengzhou, 450052, China.
authors.forename: Qiuming
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 East-Jianshe Road, Zhengzhou, 450052, China.
authors.forename: Fengyan
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 East-Jianshe Road, Zhengzhou, 450052, China.
authors.forename: Guangying
authors.initials: G
authors.lastname: Zheng
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 East-Jianshe Road, Zhengzhou, 450052, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 East-Jianshe Road, Zhengzhou, 450052, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Wan
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, No. 1 East-Jianshe Road, Zhengzhou, 450052, China. zhuyu_1zz@outlook.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D003710:Demography; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018917:Optic Neuropathy, Ischemic / Q000201:enzymology* / Q000235:genetics*
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1
keywords: Deletion genotype; GSTM1; GSTT1; Glutathione-S-Transferases; Non-arteritic anterior ischemic optic neuropathy