title: Synthesis and characterization of cell-microenvironment-sensitive leakage-free gold-shell nanoparticles with the template of interlayer-crosslinked micelles.
abstract: Novel gold-shell nanoparticles (pH-GSNPs) are designed for the first time, which exhibit drug leakage-free behavior in a physiological environment, while achieving rapid drug release and remarkable aggregation for the nanogold interlayer of pH-GSNPs to shift their absorption to far-red and NIR as a photothermal agent in the intracellular microenvironment.
authors.affiliation: School of Engineering, Sun Yat-sen University, Guangzhou 510006, P. R. China. daijian@mail.sysu.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Dai
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Li
authors.forename: Wenya
authors.initials: W
authors.lastname: Liu
authors.forename: Shudong
authors.initials: S
authors.lastname: Lin
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Hao
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Xintao
authors.initials: X
authors.lastname: Shuai
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D003432:Cross-Linking Reagents; D004317:Doxorubicin / Q000494:pharmacology*; D004337:Drug Carriers; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry*; D008823:Micelles; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D014407:Tumor Cells, Cultured; D059016:Tumor Microenvironment / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D008823:Micelles; D006046:Gold; D004317:Doxorubicin