title: Compounds Combining Aminoadamantane and Monoterpene Moieties: Cytotoxicity and Mutagenic Effects.
abstract: A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized. Their cytotoxic activity against human cancer cells CEM-13, MT-4, and U-937 has been studied for the first time. Most of the obtained compounds exhibited a significant cytotoxic activity with the median cytotoxic dose (CTD50) ranging from 6 to 84 µM. The most promising results were obtained for compound 2b which was synthesized from 1-aminoadamantane and (-)-myrtenal and revealed a high activity against all tumor lines used (CTD50 = 12 ÷ 21 µM) along with low toxicity with respect to MDCK cells (CTD50 = 1500 µM). The synthesized amines do not exert the genotoxic effect on cells of the biosensor strain based on recombinant E. coli cells bearing the pRAC-gfp plasmid.
authors.forename: Evgeniy V
authors.initials: EV
authors.lastname: Suslov
authors.forename: Konstantin Yu
authors.initials: KY
authors.lastname: Ponomarev
authors.forename: Artem D
authors.initials: AD
authors.lastname: Rogachev
authors.forename: Michail A
authors.initials: MA
authors.lastname: Pokrovsky
authors.forename: Andrey G
authors.initials: AG
authors.lastname: Pokrovsky
authors.forename: Maria B
authors.initials: MB
authors.lastname: Pykhtina
authors.forename: Anatoly B
authors.initials: AB
authors.lastname: Beklemishev
authors.forename: Dina V
authors.initials: DV
authors.lastname: Korchagina
authors.forename: Konstantin P
authors.initials: KP
authors.lastname: Volcho
authors.affiliation: Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090, Novosibirsk, Russia. redfox@nioch.nsc.ru.
authors.forename: Nariman F
authors.initials: NF
authors.lastname: Salakhutdinov
mesh_terms: D000218:Adamantane / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004285:Dogs; D006801:Humans; D061985:Madin Darby Canine Kidney Cells; D039821:Monoterpenes / Q000737:chemistry*; D009153:Mutagens / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D039821:Monoterpenes; D009153:Mutagens; D000218:Adamantane