title: Ru(II)-Pheox-Catalyzed Asymmetric Intramolecular Cyclopropanation of Electron-Deficient Olefins.
abstract: The first highly enantioselective intramolecular cyclopropanation of electron-deficient olefins, in the presence of Ru(II)--Pheox catalyst, is reported. The corresponding cyclopropane-fused γ-lactones were obtained in high yields (up to 99%) with excellent enantioselectivities (ee up to 99%). Moreover, this method enables efficient access to enantioenriched dicarbonyl cyclopropane derivatives, which are important intermediates for the synthesis of various bioactive compounds.
authors.affiliation: Department of Environmental and Life Sciences, Toyohashi University of Technology, 1-1 Tempaku-cho, Toyohashi, Aichi 441-8580, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nakagawa
authors.affiliation: Department of Environmental and Life Sciences, Toyohashi University of Technology, 1-1 Tempaku-cho, Toyohashi, Aichi 441-8580, Japan.
authors.forename: Soda
authors.initials: S
authors.lastname: Chanthamath
authors.affiliation: Department of Environmental and Life Sciences, Toyohashi University of Technology, 1-1 Tempaku-cho, Toyohashi, Aichi 441-8580, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Shibatomi
authors.affiliation: Department of Environmental and Life Sciences, Toyohashi University of Technology, 1-1 Tempaku-cho, Toyohashi, Aichi 441-8580, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Iwasa