title: Management of diffuse choroidal hemangioma in Sturge-Weber syndrome with Ruthenium-106 plaque radiotherapy.
abstract: OBJECTIVE
  To evaluate Ruthenium-106 plaque radiotherapy in the treatment of diffuse choroidal hemangioma (DCH) associated with serous retinal detachment.
  
  
  METHODS
  A retrospective analysis was performed in five patients treated for DCH associated with Sturge-Weber syndrome (SWS). In all cases, Ruthenium-106 plaque therapy with a target apex dose of 30.98-47.36 Gy (mean:38.9 Gy) was performed. The outcomes of treatment were regression of DCH, assessed by B-scan ultrasonography; resolution of serous retinal detachment, measured by B-scan ultrasonography and optical coherence tomography (OCT); changes in best corrected visual acuity (BCVA) and the development of radiation-related complications. All investigations were repeated 3 months after treatment and then at six monthly intervals within 22-122 months (mean: 62 months) of follow-up.
  
  
  RESULTS
  The initial BCVA of the affected eyes ranged from counting fingers at 1 m to 0.1 by the Snellen chart. Mean tumor basal diameter was 16.7 mm (range: 13.8 to 18.5 mm) and mean tumor thickness was 4.4 mm (range: 2.4 to 5.8 mm). Tumor regression was found in all cases with the prompt resolution of subretinal fluid. In three patients, BCVA improved and in two it remained stable. During the follow-up period, in one case secondary glaucoma was treated with transscleral cyclophotocoagulation, and in another case, recurrence of the hemangioma was treated with repeated Ruthenium-106 plaque irradiation and transpupillary therapy.
  
  
  CONCLUSIONS
  Ruthenium-106 plaque radiotherapy is an effective and safe treatment option for DCH associated with SWS. Brachytherapy led to tumor regression and resolution of serous retinal detachments, and visual stabilization was achieved in most cases.
authors.affiliation: Department of Ophthalmology, Clinic of Ophthalmology and Ocular Oncology, Jagiellonian University, Medical College, Kopernika Str. 38, 31-501, Kraków, Poland. akubicka@onet.pl.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kubicka-Trząska
authors.affiliation: Department of Ophthalmology, Clinic of Ophthalmology and Ocular Oncology, Jagiellonian University, Medical College, Kopernika Str. 38, 31-501, Kraków, Poland.
authors.forename: Izabella
authors.initials: I
authors.lastname: Karska-Basta
authors.affiliation: Department of Ophthalmology, Clinic of Ophthalmology and Ocular Oncology, Jagiellonian University, Medical College, Kopernika Str. 38, 31-501, Kraków, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Oleksy
authors.affiliation: Department of Ophthalmology, Clinic of Ophthalmology and Ocular Oncology, Jagiellonian University, Medical College, Kopernika Str. 38, 31-501, Kraków, Poland.
authors.forename: Bożena
authors.initials: B
authors.lastname: Romanowska-Dixon
mesh_terms: D000328:Adult; D001918:Brachytherapy; D002648:Child; D002830:Choroid Neoplasms / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006391:Hemangioma / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D011879:Radiotherapy Dosage; D012163:Retinal Detachment / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use*; D013341:Sturge-Weber Syndrome / Q000150:complications / Q000532:radiotherapy*; D041623:Tomography, Optical Coherence; D014463:Ultrasonography; D014792:Visual Acuity / Q000502:physiology
chemical_list: D012429:Ruthenium Radioisotopes
keywords: Diffuse choroidal hemangioma; Plaque radiotherapy; Serous retinal detachment; Sturge-Weber syndrome