title: High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing's disease.
abstract: OBJECTIVE
  To evaluate the detection of pituitary lesions at 7.0 T compared to 1.5 T MRI in 16 patients with clinically and biochemically proven Cushing's disease.
  
  
  METHODS
  In seven patients, no lesion was detected on the initial 1.5 T MRI, and in nine patients it was uncertain whether there was a lesion. Firstly, two readers assessed both 1.5 T and 7.0 T MRI examinations unpaired in a random order for the presence of lesions. Consensus reading with a third neuroradiologist was used to define final lesions in all MRIs. Secondly, surgical outcome was evaluated. A comparison was made between the lesions visualized with MRI and the lesions found during surgery in 9/16 patients.
  
  
  RESULTS
  The interobserver agreement for lesion detection was good at 1.5 T MRI (κ = 0.69) and 7.0 T MRI (κ = 0.62). In five patients, both the 1.5 T and 7.0 T MRI enabled visualization of a lesion on the correct side of the pituitary gland. In three patients, 7.0 T MRI detected a lesion on the correct side of the pituitary gland, while no lesion was visible at 1.5 T MRI.
  
  
  CONCLUSIONS
  The interobserver agreement of image assessment for 7.0 T MRI in patients with Cushing's disease was good, and lesions were detected more accurately with 7.0 T MRI.
  
  
  CONCLUSIONS
  Interobserver agreement for lesion detection on 1.5 T MRI was good; Interobserver agreement for lesion detection on 7.0 T MRI was good; 7.0 T enabled confirmation of unclear lesions at 1.5 T; 7.0 T enabled visualization of lesions not visible at 1.5 T.
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, Postbox 85500, 3508 GA, Utrecht, The Netherlands. A.A.J.deRotte@umcutrecht.nl.
authors.forename: Alexandra A J
authors.initials: AA
authors.lastname: de Rotte
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, Postbox 85500, 3508 GA, Utrecht, The Netherlands.
authors.forename: Amy
authors.initials: A
authors.lastname: Groenewegen
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, Postbox 85500, 3508 GA, Utrecht, The Netherlands.
authors.forename: Dik R
authors.initials: DR
authors.lastname: Rutgers
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, Postbox 85500, 3508 GA, Utrecht, The Netherlands.
authors.forename: Theo
authors.initials: T
authors.lastname: Witkamp
authors.affiliation: Department of Internal Medicine (Section of Endocrinology), University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Pierre M J
authors.initials: PM
authors.lastname: Zelissen
authors.affiliation: Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: F J Anton
authors.initials: FJ
authors.lastname: Meijer
authors.affiliation: Department of Neurosurgery, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Erik J
authors.initials: EJ
authors.lastname: van Lindert
authors.affiliation: Department of Internal Medicine (Section of Endocrinology), Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Ad
authors.initials: A
authors.lastname: Hermus
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, Postbox 85500, 3508 GA, Utrecht, The Netherlands.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Luijten
authors.affiliation: Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, Postbox 85500, 3508 GA, Utrecht, The Netherlands.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Hendrikse
mesh_terms: D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D047748:Pituitary ACTH Hypersecretion / Q000175:diagnosis*; D010902:Pituitary Gland / Q000473:pathology*
keywords: Cushing’s disease, pituitary; Magnetic resonance imaging; Pituitary ACTH hypersecretion; Pituitary adenoma; Pituitary gland