title: Aminocarbonylation of aryl tosylates to carboxamides.
abstract: The palladium - catalyzed aminocarbonylation of aryl tosylates with amines is reported. Suitable conditions were identified by high throughput reaction screening and then further optimized. The substrate scope of the reaction with respect to the aryl tosylate component and the amine component are reported. Competitive aminolysis of the aryl tosylates to afford the amine toluenesulfonamides and the phenol was not observed.
authors.forename: Seungwon
authors.initials: S
authors.lastname: Chung
authors.affiliation: ‡Oncology Chemistry, Pfizer Global Research and Development, 10770 Science Center Drive, La Jolla, California 92121, United States.
authors.forename: Neal
authors.initials: N
authors.lastname: Sach
authors.forename: Chulho
authors.initials: C
authors.lastname: Choi
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Yang
authors.forename: Susan E
authors.initials: SE
authors.lastname: Drozda
authors.forename: Robert A
authors.initials: RA
authors.lastname: Singer
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Wright
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000737:chemistry; D014105:Tosyl Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D010648:Phenylacetates; D014105:Tosyl Compounds; D010165:Palladium