title: Monoterpenes from the leaves of Hydrangea paniculata and their hepatoprotective activities.
abstract: Three new monoterpenes, hydrangines A-C (1-3), together with four known compounds, were isolated from the ethanol extract of the leaves of Hydrangea paniculata. The structures of new isolates were elucidated on the basis of extensive 1D and 2D NMR analyses, and their absolute configurations were determined by comparison of experimental and calculated electronic circular dichroism spectra. In in vitro bioassays at 10 μM, compounds 1-6 showed hepatoprotective activities against dl-galactosamine-induced toxicity in HL-7702 cells.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.forename: Jing-Zhi
authors.initials: JZ
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
mesh_terms: D005688:Galactosamine; D031966:Hydrangea / Q000737:chemistry*; D008099:Liver / Q000187:drug effects*; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D039821:Monoterpenes; D005688:Galactosamine
keywords: ECD; Hydrangea paniculata; Saxifragaceae; hepatoprotective activities; monoterpenes