title: Isoniazid-induced Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Presenting as Acute Eosinophilic Myocarditis.
abstract: It has been reported that hypereosinophilic syndrome may be induced by antituberculosis drugs. We herein report the case of a 43-year-old man who had been on antituberculosis drugs for two months to treat tuberculous meningitis. During therapy, he suffered from drug rash with eosinophilia and systemic symptoms (DRESS) presenting as acute eosinophilic myocarditis, as confirmed on a histopathologic examination. According to the patient's medication history, clinical features and accessory examination findings, the eosinophilic myocarditis was thought to be possibly induced by isoniazid. Although further investigations are needed to confirm causality, isoniazid may be added to the list of drugs with the potential to cause DRESS syndrome.
authors.affiliation: Department of Infection and Liver Diseases, The First Affiliated Hospital of Wenzhou Medical University, China.
authors.forename: Sai-Nan
authors.initials: SN
authors.lastname: Zhang
authors.forename: Qiu-Xiang
authors.initials: QX
authors.lastname: He
authors.forename: Nai-Bin
authors.initials: NB
authors.lastname: Yang
authors.forename: Shun-Lan
authors.initials: SL
authors.lastname: Ni
authors.forename: Ming-Qin
authors.initials: MQ
authors.lastname: Lu
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology / Q000473:pathology*; D005076:Exanthema / Q000139:chemically induced; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000139:chemically induced* / Q000473:pathology; D007538:Isoniazid / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009205:Myocarditis / Q000139:chemically induced* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid