title: Migraine-specific quality of life questionnaire and relapse of medication overuse headache.
abstract: BACKGROUND
  The management of Medication overuse headache (MOH) represents a difficult challenge for clinicians and headache experts, particularly for the responder rate after a successful withdrawal treatment. The purpose of this study was to investigate the role of demographic and clinical characteristics as well as the score of Migraine-Specific Quality of Life Questionnaire (MSQ), Migraine Disability Questionnaire and Leeds Dependence Questionnaire in predicting a response after a successful withdrawal treatment in patients with MOH.
  
  
  METHODS
  This ancillary study is part of a randomized trial that demonstrated the safety and the efficacy of a 3-month treatment with sodium valproate (VPA) (800 mg/day vs placebo) in MOH. Demographic and clinical characteristics and questionnaire results were obtained from the entire sample.
  
  
  RESULTS
  A significant correlation was found only between MOH relapse and the total MSQ score, the Role Preventive sub-scale and the Emotional Function sub-scale, suggesting a poorer quality of life in non responders.
  
  
  CONCLUSIONS
  A high MSQ score could be associated with a poor short-term outcome in MOH patients after a successful treatment with detoxification followed by a new treatment.
authors.affiliation: Clinica Neurologica, Azienda Ospedaliera - Università di Perugia, Perugia, Italy. stefano.caproni@gmail.com.
authors.forename: Stefano
authors.initials: S
authors.lastname: Caproni
authors.affiliation: IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy. elisa.bianchi@marionegri.it.
authors.forename: Elisa
authors.initials: E
authors.lastname: Bianchi
authors.affiliation: Centro Cefalee e Malattie Cerebrovascolari, Ospedale S. Eugenio, Rome, Italy. lecupini@tin.it.
authors.forename: Letizia M
authors.initials: LM
authors.lastname: Cupini
authors.affiliation: Clinica Neurologica, Azienda Ospedaliera - Università di Perugia, Perugia, Italy. corbelli.ilenia@gmail.com.
authors.forename: Ilenia
authors.initials: I
authors.lastname: Corbelli
authors.affiliation: IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy. ettore.beghi@marionegri.it.
authors.forename: Ettore
authors.initials: E
authors.lastname: Beghi
authors.affiliation: Clinica Neurologica, Azienda Ospedaliera - Università di Perugia, Perugia, Italy. paolo.calabresi@unipg.it.|IRCCS Fondazione "S. Lucia", Rome, Italy. paolo.calabresi@unipg.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Calabresi
authors.affiliation: Clinica Neurologica, Azienda Ospedaliera - Università di Perugia, Perugia, Italy. paola.sarchielli@gmail.com.
authors.forename: Paola
authors.initials: P
authors.lastname: Sarchielli
mesh_terms: D000328:Adult; D005260:Female; D051271:Headache Disorders, Secondary / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D015337:Multicenter Studies as Topic; D017063:Outcome Assessment, Health Care; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires