title: Pharmacokinetic Profile of Eight Phenolic Compounds and Their Conjugated Metabolites after Oral Administration of Rhus verniciflua Extracts in Rats.
abstract: Rhus verniciflua (Toxicodendron vernicifluum) is a medicinal tree popularly used in Asian countries such as China, Japan, and Korea as a food additive or herbal medicine because of its beneficial effects. R. verniciflua extract (RVE) contains diverse phenolic compounds, such as flavonoids, as its major biological active constituents. In this study, the pharmacokinetic profiles of eight phenolic compounds were investigated following oral administration of RVE to rats. The eight phenolic compounds were 2,4-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, fisetin, fustin, butin, sulfuretin, taxifolin, and garbanzol. The plasma concentrations of the eight compounds were determined by using a liquid chromatography-triple-quadrupole mass spectrometer before and after treatment with β-glucuronidase. When 1.5 g/kg RVE was administered, the eight compounds were all detected in plasma, mainly as conjugated forms. These pharmacokinetic data would be useful for understanding the pharmacological effects of RVE.
authors.affiliation: †Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 426-791, Korea.
authors.forename: Ming Ji
authors.initials: MJ
authors.lastname: Jin
authors.affiliation: †Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 426-791, Korea.
authors.forename: In Sook
authors.initials: IS
authors.lastname: Kim
authors.affiliation: †Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 426-791, Korea.
authors.forename: Jong Suk
authors.initials: JS
authors.lastname: Park
authors.affiliation: §School of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Korea.
authors.forename: Mi-Sook
authors.initials: MS
authors.lastname: Dong
authors.affiliation: #Lifetree Biotech Company, Ltd., Suwon, Gyeonggi-do 441-350, Korea.
authors.forename: Chun-Soo
authors.initials: CS
authors.lastname: Na
authors.affiliation: †Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do 426-791, Korea.
authors.forename: Hye Hyun
authors.initials: HH
authors.lastname: Yoo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D008297:Male; D015394:Molecular Structure; D010636:Phenols / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D056910:Republic of Korea; D029045:Rhus / Q000737:chemistry*
chemical_list: D010636:Phenols; D010936:Plant Extracts
keywords: Rhus verniciflua Stokes; bioanalytical method; pharmacokinetics; phenolic compounds