title: [Association between CYP1A1 genetic polymorphisms and coronary artery disease in Uygur population in Xinjiang, China].
abstract: OBJECTIVE
  To assess the association between human CYP1A1 gene polymorphisms and coronary artery disease (CAD) among the Uygur population of China.
  
  
  METHODS
  Genotypes of CYP1A1 single nucleotide polymorphisms (SNPs: rs4886605, rs12441817, rs4646422 and rs1048943) were detected by real-time PCR in 293 CAD patients and 408 controls.
  
  
  RESULTS
  Among the Uygur group, distribution of genotypes and allele of rs4886605 were both significantly different between CAD and the controls (all P < 0.05). The dominant model (CC vs. CT+TT) of rs4886605 was significantly lower among CAD patients than in controls. Significant differences were retained after the adjustment was made in all the participants (OR = 0.368, 95% CI: 0.185-0.530, P = 0.018) and in men (OR = 0.350, 95% CI: 0.235-0.568, P = 0.015). Distributions of genotypes and allele of rs12441817 were both significantly different between CAD and the controls (all P < 0.05). The dominant model (TT vs. CT+CC) of rs12441817 was significantly lower among patients CAD than in controls. Significant difference were retained after the adjustment was made, in total participants (OR = 0.253, 95% CI: 0.231-0.546, P = 0.016) and in men (OR = 0.241, 95% CI: 0.132-0.478, P = 0.002).
  
  
  CONCLUSIONS
  Both rs4886605 and rs12441817 SNPs of the CYP1A1 gene were associated with CAD in the Uygur population of China.
authors.affiliation: Department of Cardiology; Xinjiang Key Laboratory of Cardiovascular Disease Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Jinguo
authors.initials: J
authors.lastname: Zou
authors.affiliation: Department of Cardiology; Xinjiang Key Laboratory of Cardiovascular Disease Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China; Email: myt_xj@sina.com.
authors.forename: Yitong
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Department of Cardiology; Xinjiang Key Laboratory of Cardiovascular Disease Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Cardiology; Xinjiang Key Laboratory of Cardiovascular Disease Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Yining
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Xinjiang Key Laboratory of Cardiovascular Disease Research, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003324:Coronary Artery Disease / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics* / Q000706:statistics & numerical data; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D019363:Cytochrome P-450 CYP1A1