title: Levels of Myeloperoxidase and Alkaline Phosphatase in Periimplant Sulcus Fluid in Health and Disease and After Nonsurgical Therapy.
abstract: OBJECTIVE
  The study evaluated 2 biomarkers (myeloperoxidase [MPO] and alkaline phosphatase) along with clinical parameters in periimplant sulcus fluid (PISF) in conditions of periimplant health and disease. The effect of nonsurgical therapy was also evaluated on the biochemical and clinical parameters in diseased implants at 3 months after the baseline.
  
  
  METHODS
  A total number of 30 implants were studied in 20 subjects and divided into healthy group (group 1) and periimplant disease group (group 2). PISF was collected in both groups along with recording of clinical parameters. The periimplant disease group was then instituted a nonsurgical anti-infective therapy. The clinical and biochemical parameters were evaluated and compared at baseline and at the end of 3 months.
  
  
  RESULTS
  Group 2 showed statistically significant higher PISF MPO values at baseline as compared with groups 1 and 2 (at 3 months) (P < 0.001). Also, difference in the mean value of PISF MPO in group 2 (at 3 months) was greater than that in group 1 and was statistically nonsignificant (P = 1.85).
  
  
  CONCLUSIONS
  Within confines of the study, it can be concluded that evaluation of biochemical markers in PISF can be a useful diagnostic tool to aid the clinician in decision making regarding the management of the condition.
authors.affiliation: *No current academic position or practice. †Professor and Dean, Department of Periodontology, Manipal College of Dental Sciences, Mangalore, India. ‡Professor and Head, Department of Periodontology, Manipal College of Dental Sciences, Mangalore, India.
authors.forename: Nikita
authors.initials: N
authors.lastname: Malik
authors.forename: Dilip
authors.initials: D
authors.lastname: Naik
authors.forename: Ashita
authors.initials: A
authors.lastname: Uppoor
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D002710:Chlorhexidine / Q000627:therapeutic use; D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects*; D012534:Dental Scaling; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000175:diagnosis*; D010518:Periodontitis / Q000175:diagnosis* / Q000628:therapy*; D009195:Peroxidase / Q000032:analysis*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D015921:Dental Implants; D009195:Peroxidase; D000469:Alkaline Phosphatase; D002710:Chlorhexidine