title: Neural tissue regeneration in experimental brain injury model with channeled scaffolds of acrylate copolymers.
abstract: The objective of the present study was to evaluate the biocompatibility and cell hosting ability of a copolymer scaffold based on ethyl acrylate (EA) and hydroxyl ethyl acrylate (HEA) in vivo after an experimental brain injury. Wistar rats were subjected to cryogenic traumatic brain injury. We evaluated the tissue response to the implanted materials after 8 weeks. The materials were implanted devoid of cells; they provoked a minimal scar response by the host tissue and permitted the invasion of neurons and glia inside them. We also found new blood vessels surrounding and inside the implant. Thus, the copolymer scaffold proves to offer a suitable environment producing a cellular network potentially useful in brain repair after brain injury.
authors.affiliation: Centro de Biomateriales, Universitat Politècnica de València, P. O. Box 22012, E-46071 València, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Martínez-Ramos
authors.affiliation: Servicio de Neurocirugía, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), C/ Profesor Martín Lagos, S/N, 28040 Madrid, Spain; Red de Terapia Celular (TerCel), Instituto Nacional de Salud Carlos III, Spain.
authors.forename: Ulises
authors.initials: U
authors.lastname: Gómez-Pinedo
authors.affiliation: Facultad Ciencias de la Salud, Universidad CEU Cardenal Herrera, Avda. Seminario 46113 Moncada, Spain.
authors.forename: Maria Angeles Garcia
authors.initials: MA
authors.lastname: Esparza
authors.affiliation: Facultad Ciencias de la Salud, Universidad CEU Cardenal Herrera, Avda. Seminario 46113 Moncada, Spain; Red de Terapia Celular (TerCel), Instituto Nacional de Salud Carlos III, Spain.
authors.forename: José Miguel
authors.initials: JM
authors.lastname: Soria
authors.affiliation: Servicio de Neurocirugía, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), C/ Profesor Martín Lagos, S/N, 28040 Madrid, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto Nacional de Salud Carlos III, Spain; Red de Terapia Celular (TerCel), Instituto Nacional de Salud Carlos III, Spain; Departamento de Cirugía, Universidad Complutense de Madrid, Spain. Electronic address: jabarcia@ucm.es.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Barcia
authors.affiliation: Centro de Biomateriales, Universitat Politècnica de València, P. O. Box 22012, E-46071 València, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto Nacional de Salud Carlos III, Spain; Red de Terapia Celular (TerCel), Instituto Nacional de Salud Carlos III, Spain. Electronic address: mmonleon@upvnet.upv.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Monleón Pradas
mesh_terms: D000179:Acrylates; D000818:Animals; D001253:Astrocytes / Q000502:physiology; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D002465:Cell Movement; D002540:Cerebral Cortex / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D042783:Endothelial Cells / Q000502:physiology; D005260:Female; D018919:Neovascularization, Physiologic; D009416:Nerve Regeneration; D016501:Neurites / Q000502:physiology; D017208:Rats, Wistar; D054457:Tissue Scaffolds
chemical_list: D000179:Acrylates; C523542:poly(ethyl acrylate-co-hydroxyethyl acrylate)
keywords: Angiogenesis; Brain; Cryolesion; Scaffold; Tissue engineering