title: Effect of oxytocin and PGF2α on chlortetracycline absorption from the uterus of early postpartum camels (Camelus dromedarius).
abstract: Fifteen parturient camels given chlortetracycline (CTC) as intrauterine pessaries (3 g/head) were divided into the control group (n = 5), which remained untreated, oxytocin-treated group (50 IU, intramuscular; n = 5), and cloprostenol-treated group (Estrumate, 500 μg, intramuscular; n = 5). Serum samples were collected at 0, 1, 2, 4, 8, 24, 48, and 72 hours after treatment and CTC was determined. The CTC appeared in blood within 1 hour. The maximum concentration of CTC was detected in blood after 72 (543.58 ± 117.85 μg/L), 8 (520.48 ± 13.65 μg/L), and 1 hour (831.98 ± 111.01 μg/L) of administration in control, oxytocin-, and PGF2α-treated camels, respectively. There was a high significant effect of time (P < 0.001) and treatment-by-time interaction (P < 0.001) on serum CTC concentration. In the control group, there was a significant (P < 0.05) increase in CTC concentrations at 72 hours compared to the other times. In the oxytocin group, there was a significant (P < 0.05) decrease in CTC concentrations at 24, 48, and 72 hours compared to its level after 1 or 8 hours. In PGF2α, there was a significant (P < 0.001) decrease in CTC concentrations at 2, 4, 8, 24, 48, and 72 hours compared to its level after 1 hour. Treatment contrast at different time points showed a significant (P < 0.001) increase in CTC concentration after 1 hour in the PGF2α-treated group compared to oxytocin and control groups. By 72 hours, CTC concentrations were significantly (P < 0.05) lower in PGF2α and oxytocin groups than in the control group. In conclusion, serum CTC concentration in dromedary camels increases within 1 hour after intrauterine administration and remains elevated for at least 72 hours in control, oxytocin-, and PGF2α-treated animals.
authors.affiliation: Department of Clinical Studies, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia; Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
authors.forename: I M
authors.initials: IM
authors.lastname: Ghoneim
authors.affiliation: Department of Central Lab of Chemical Analysis, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia; Physiology Department, Plant Protection Research Institute (PPRI), Agricultural Research Centre (ARC), Giza, Egypt.
authors.forename: A M
authors.initials: AM
authors.lastname: Abdelghany
authors.affiliation: Department of Clinical Studies, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia; Department of Theriogenology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt. Electronic address: mmwaheed@hotmail.com.
authors.forename: M M
authors.initials: MM
authors.lastname: Waheed
authors.affiliation: Department of Clinical Studies, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia; Department of Hygiene and Preventive Medicine, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
authors.forename: A M
authors.initials: AM
authors.lastname: Elmoslemany
authors.affiliation: Department of Clinical Studies, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.
authors.forename: A K
authors.initials: AK
authors.lastname: Alhaider
authors.affiliation: Department of Clinical Studies, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.
authors.forename: M M
authors.initials: MM
authors.lastname: Al-Eknah
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002162:Camelus; D002751:Chlortetracycline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D015237:Dinoprost / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D010120:Oxytocics / Q000008:administration & dosage / Q000493:pharmacokinetics; D010121:Oxytocin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D049590:Postpartum Period; D011247:Pregnancy
chemical_list: D000900:Anti-Bacterial Agents; D010120:Oxytocics; D010121:Oxytocin; D015237:Dinoprost; D002751:Chlortetracycline
keywords: Camel; Chlortetracycline; Oxytocin; PGF2α; Uterus