title: Nasal septum perforation in patient with pyoderma gangrenosum.
abstract: BACKGROUND
  The cocaine is obtained from the leaves of the coca (Erythroxylon coca). It can be used in many ways, but the most common is the drug inhalation. The Cocaine also causes vasoconstriction at nasal mucous membrane and its chronic use can cause necrosis and nasal septum perforation. Pyoderma gangrenosum is an uncommon idiopathic disease characterized by ulcerations, usually observed on the legs. Its diagnosis is most common an exclusion of others diseases. So far, there is no specific treatment based on evidence by randomized controlled trials.
  
  
  OBJECTIVE
  Describe the rare association between Pyoderma gangrenosum and cocaine.
  
  
  METHODS
  E. A., 27-year-old woman with destruction of nasal septum and palate who has been using a big amount of cocaine, been necessary note the difference from which disease cause de damage. Final Comments: Also there are only three cases of Pyoderma gangrenosum complicated with nasal septum perforation in cocaine users.
authors.affiliation: Resident Doctor of Otolaryngology.
authors.forename: Camilla Bezerra da Cruz
authors.initials: CB
authors.lastname: Maia
authors.affiliation: Master for the UFRJ. Doctor of the Department of Otolaryngology of the State Serving Hospital, Health department, Rio de Janeiro.
authors.forename: Felippe
authors.initials: F
authors.lastname: Felix
authors.affiliation: Medical Teacher of the Hospital of the State Server.
authors.forename: Vania
authors.initials: V
authors.lastname: Paes
authors.affiliation: Resident Doctor (a) of Otolaryngology of the Hospital of the State Server, Health department, Rio de Janeiro.
authors.forename: Julia Alves
authors.initials: JA
authors.lastname: de Azevedo
authors.affiliation: Resident Doctor of Dermatology of the Hospital of the State Server, Health department, Rio de Janeiro.
authors.forename: Eliza Raquel Negrão
authors.initials: ER
authors.lastname: Grangeiro
authors.affiliation: Resident Doctor (a) of Otolaryngology of the Hospital of the State Server, Health department, Rio de Janeiro.
authors.forename: Jonatah Lucas N
authors.initials: JL
authors.lastname: Riccio
authors.affiliation: Resident Doctor (a) of Otolaryngology of the Hospital of the State Server, Health department, Rio de Janeiro.
authors.forename: Helen Cruz
authors.initials: HC
authors.lastname: Rito
keywords: diagnosis; nasal septum; pyoderma gangrenosum