title: Experimental efficacy of anidulafungin against Aspergillus terreus species complex.
abstract: Whereas echinocandins are alternatives for the treatment of invasive aspergillosis, the efficacy of anidulafungin (AFG) against Aspergillus terreus infection has not yet been explored. We have evaluated the in vitro activity, as well as the in vivo efficacy of AFG in neutropenic mice infected by A. terreus species complex. Time-kill studies showed in vitro fungistatic activity of AFG against two strains. AFG at doses of 5 and 10 mg/kg/day significantly reduced the fungal load in kidney of mice, but only the higher dose was able to prolong survival.
authors.affiliation: Unitat de Microbiologia.
authors.forename: Marta
authors.initials: M
authors.lastname: Sanchis
authors.affiliation: Unitat de Microbiologia.
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
authors.affiliation: Unitat d'Anatomia Patològica, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.affiliation: Unitat de Microbiologia.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Pastor
authors.affiliation: Unitat de Microbiologia josep.guarro@urv.cat.
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology*; D001230:Aspergillus / Q000187:drug effects*; D004195:Disease Models, Animal; D054714:Echinocandins / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000382:microbiology; D051379:Mice
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D000077612:Anidulafungin
keywords: Aspergillus terreus; anidulafungin; antifungals; echinocandins; fungal infections; murine models