title: Mussel-Inspired Electrospun Nanofibers Functionalized with Size-Controlled Silver Nanoparticles for Wound Dressing Application.
abstract: Electrospun nanofibers that contain silver nanoparticles (AgNPs) have a strong antibacterial activity that is beneficial to wound healing. However, most of the literature available on the bactericidal effects of this material is based on the use of AgNPs with uncontrolled size, shape, surface properties, and degree of aggregation. In this study, we report the first versatile synthesis of novel catechol moieties presenting electrospun nanofibers functionalized with AgNPs through catechol redox chemistry. The synthetic strategy allows control of the size and amount of AgNPs on the surface of nanofibers with the minimum degree of aggregation. We also evaluated the rate of release of the AgNPs, the biocompatibility of the nanofibers, the antibacterial activity in vitro, and the wound healing capacity in vivo. Our results suggest that these silver-releasing nanofibers have great potential for use in wound healing applications.
authors.forename: Amin
authors.initials: A
authors.lastname: GhavamiNejad
authors.forename: Afeesh
authors.initials: A
authors.lastname: Rajan Unnithan
authors.forename: Arathyram
authors.initials: A
authors.lastname: Ramachandra Kurup Sasikala
authors.forename: Melisa
authors.initials: M
authors.lastname: Samarikhalaj
authors.affiliation: §Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Reju George
authors.initials: RG
authors.lastname: Thomas
authors.affiliation: §Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea.
authors.forename: Yong Yeon
authors.initials: YY
authors.lastname: Jeong
authors.affiliation: ⊥Department of BIN Fusion Technology, Chonbuk National University, Jeonju, South Korea.
authors.forename: Saeed
authors.initials: S
authors.lastname: Nasseri
authors.affiliation: ⊥Department of BIN Fusion Technology, Chonbuk National University, Jeonju, South Korea.
authors.forename: Priya
authors.initials: P
authors.lastname: Murugesan
authors.affiliation: ⊥Department of BIN Fusion Technology, Chonbuk National University, Jeonju, South Korea.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
authors.forename: Chan
authors.initials: C
authors.lastname: Hee Park
authors.forename: Cheol Sang
authors.initials: CS
authors.lastname: Kim
mesh_terms: D000178:Acrylamides / Q000138:chemical synthesis / Q000737:chemistry; D000818:Animals; D048271:Chitosan / Q000737:chemistry; D004298:Dopamine / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D055664:Electrochemical Techniques; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D057139:Nanofibers / Q000737:chemistry* / Q000627:therapeutic use; D058105:Polymerization; D051381:Rats; D012834:Silver / Q000737:chemistry* / Q000627:therapeutic use; D013211:Staphylococcus aureus / Q000187:drug effects / Q000472:pathogenicity; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000178:Acrylamides; D012834:Silver; D048271:Chitosan; C045985:methacrylamide; D004298:Dopamine
keywords: dopamine; electrospinning; mussel-inspired; nanofiber; silver nanoparticles; wound healing