title: The Importance of NLRP3 Inflammasome in Heart Failure.
abstract: Patients with heart failure continue to suffer adverse health consequences despite advances in therapies over the past 2 decades. Identification of novel therapeutic targets that may attenuate disease progression is therefore needed. The inflammasome may play a central role in modulating chronic inflammation and in turn affecting heart failure progression. The inflammasome is a complex of intracellular interaction proteins that trigger maturation of proinflammatory cytokines interleukin-1β and interleukin-18 to initiate the inflammatory response. This response is amplified through production of tumor necrosis factor α and activation of inducible nitric oxide synthase. The purpose of this review is to discuss recent evidence implicating this inflammatory pathway in the pathophysiology of heart failure.
authors.affiliation: Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA.
authors.forename: Brittany
authors.initials: B
authors.lastname: Butts
authors.affiliation: Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Gary
authors.affiliation: Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA.
authors.forename: Sandra B
authors.initials: SB
authors.lastname: Dunbar
authors.affiliation: Cardiology Division, Stony Brook University, Stony Brook, NY. Electronic address: javed.butler@stonybrookmedicine.edu.
authors.forename: Javed
authors.initials: J
authors.lastname: Butler
mesh_terms: D002352:Carrier Proteins / Q000276:immunology*; D018450:Disease Progression; D006333:Heart Failure / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D018836:Inflammation Mediators; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human
keywords: Heart failure; inflammasome; inflammation