title: Disposition, metabolism and mass balance of delafloxacin in healthy human volunteers following intravenous administration.
abstract: 1. The pharmacokinetics and disposition of delafloxacin was investigated following a single intravenous (300 mg, 100 µCi) dose to healthy male subjects. 2. Mean Cmax, AUC0-∞, Tmax and t1/2 values for delafloxacin were 8.98 µg/mL, 21.31 µg h/mL, 1 h and 2.35 h, respectively, after intravenous dosing. 3. Radioactivity was predominantly excreted via the kidney with 66% of the radioactive dose recovered in the urine. Approximately 29% of the radioactivity was recovered in the faeces, giving an overall mean recovery of 94% administered radioactivity. 4. The predominant circulating components were identified as delafloxacin and a direct glucuronide conjugate of delafloxacin.
authors.affiliation: a Department of Metabolism, Quotient Bioresearch , Pegasus Way, Rushden , UK .
authors.forename: Andrew
authors.initials: A
authors.lastname: McEwen
authors.affiliation: b Melinta Therapeutics Inc. , New Haven, CT , USA , and.
authors.forename: Laura
authors.initials: L
authors.lastname: Lawrence
authors.affiliation: b Melinta Therapeutics Inc. , New Haven, CT , USA , and.
authors.forename: Randy
authors.initials: R
authors.lastname: Hoover
authors.affiliation: c Quotient Clinical , Nottingham , UK.
authors.forename: Lloyd
authors.initials: L
authors.lastname: Stevens
authors.affiliation: c Quotient Clinical , Nottingham , UK.
authors.forename: Stuart
authors.initials: S
authors.lastname: Mair
authors.affiliation: a Department of Metabolism, Quotient Bioresearch , Pegasus Way, Rushden , UK .
authors.forename: Gill
authors.initials: G
authors.lastname: Ford
authors.affiliation: a Department of Metabolism, Quotient Bioresearch , Pegasus Way, Rushden , UK .
authors.forename: Dylan
authors.initials: D
authors.lastname: Williams
authors.affiliation: a Department of Metabolism, Quotient Bioresearch , Pegasus Way, Rushden , UK .
authors.forename: Stuart
authors.initials: S
authors.lastname: Wood
mesh_terms: D061605:Administration, Intravenous; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D005243:Feces / Q000737:chemistry; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D020719:Glucuronides / Q000378:metabolism; D064368:Healthy Volunteers; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D020719:Glucuronides; C477891:delafloxacin
keywords: Delafloxacin; human; metabolism; quinolone