title: IL-2: Change Structure … Change Function.
abstract: In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences.
authors.affiliation: Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA. Electronic address: jeff.bluestone@ucsf.edu.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Bluestone
authors.affiliation: Pfizer Centers for Therapeutic Innovation, San Francisco, CA 94158, USA.
authors.forename: Natasha
authors.initials: N
authors.lastname: Crellin
authors.affiliation: Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Trotta
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism*; D008958:Models, Molecular; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology*
chemical_list: D000906:Antibodies; D007376:Interleukin-2