title: High DHEAS/free testosterone ratio is related to better metabolic parameters in women with PCOS.
abstract: OBJECTIVE
  To demonstrate the effects of DHEAS/free testosterone (DHEAS/FT) ratio on metabolic parameters in women with and without polycystic ovary syndrome (PCOS).
  
  
  METHODS
  The data of 91 women with PCOS and 66 women in the control group were collected retrospectively.
  
  
  RESULTS
  DHEAS/FT of the control group was higher than that of PCOS group (684.93 ± 300.54 to 517.2 ± 300.8, p < 0.001). DHEAS/FT correlated with BMI (r = -0.352, p = 0.001), WHR (r = -0.371, p = 0.0219), LDL (r = -0.227, p = 0.031), HOMA-IR (r = -0.36, p = 0.001) and FAI (r = -0.639, p = 0.001) negatively and with HDL (r = 0.344, p = 0.001) and SHBG (r = 0.646, p = 0.001) positively. In the control group, DHEAS/FT correlated with BMI (r = -0.334, p = 0.007), CRP (r = -0.297, p = 0.016) and FAI (r = -0.399, p = 0.01) negatively.
  
  
  CONCLUSIONS
  High DHEAS/FT ratios are related to a better metabolic phenotype in women with PCOS and low levels can be used to detect women with PCOS that have a higher risk of metabolic problems.
authors.affiliation: Department of Obstetrics and Gynecology, İstanbul Bilim University , İstanbul , Turkey .
authors.forename: Nilgün
authors.initials: N
authors.lastname: Güdücü
authors.forename: Salih Serdar
authors.initials: SS
authors.lastname: Kutay
authors.forename: Uzay
authors.initials: U
authors.lastname: Görmüş
authors.forename: Zehra Neşe
authors.initials: ZN
authors.lastname: Kavak
authors.forename: İlkkan
authors.initials: İ
authors.lastname: Dünder
mesh_terms: D000293:Adolescent; D000328:Adult; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D006801:Humans; D008659:Metabolic Diseases / Q000097:blood* / Q000209:etiology; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D013739:Testosterone / Q000097:blood*; D055815:Young Adult
chemical_list: D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate
keywords: DHEAS; free testosterone; metabolism; polycystic ovary syndrome