title: Arterial Stiffness and Peripheral and Central Blood Pressure in Patients With Sickle Cell Disease.
abstract: Blood pressure (BP) in patients with sickle cell disease (SCD) has been reported to be lower than in persons in the general population. Data on arterial stiffness, which is an important risk factor for the progression of BP, are inconclusive for this patient population. Forty-five adult patients with SCD and 40 controls matched for sex, age, and body mass index were studied. Brachial systolic BP (SBP) and diastolic BP (DBP) were significantly lower in the patient group (SBP 115.1±13.8 mm Hg vs 121.9±11.3 mm Hg and DBP 68.5±8.0 mm Hg vs 80.6±9.1 mm Hg, P<.05, respectively). Augmentation index (AIx), however, was significantly higher in SCD patients compared with healthy controls (24.9±9.6 for patients vs 12.4±10.8 for controls, P<.001), while carotid femoral pulse wave velocity was comparable between the two groups. The study shows that mechanisms other than arterial elasticity are involved in the low BP phenotype of patients with SCD.
authors.affiliation: Hypertension Excellence Center, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Pikilidou
authors.affiliation: Division of Clinical and Molecular Endocrinology, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Yavropoulou
authors.affiliation: Hypertension Excellence Center, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Antoniou
authors.affiliation: Hypertension Excellence Center, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Papakonstantinou
authors.affiliation: Division of Hematology and Thalassemia Unit, 1st Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Despoina
authors.initials: D
authors.lastname: Pantelidou
authors.affiliation: Division of Hematology and Thalassemia Unit, 1st Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Panagiota
authors.initials: P
authors.lastname: Chalkia
authors.affiliation: Department of Clinical Sciences, Lund University, Malmo, Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Nilsson
authors.affiliation: Division of Clinical and Molecular Endocrinology, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Yovos
authors.affiliation: Hypertension Excellence Center, AHEPA University Hospital, Thessaloniki, Greece.
authors.forename: Pantelis
authors.initials: P
authors.lastname: Zebekakis
mesh_terms: D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000175:diagnosis / Q000503:physiopathology*; D062186:Arterial Pressure / Q000502:physiology; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D001916:Brachial Artery / Q000502:physiology; D005260:Female; D005293:Ferritins / Q000378:metabolism; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D063177:Pulse Wave Analysis / Q000379:methods*; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D005293:Ferritins