title: Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score.
abstract: To determine cut-off value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters for differentiation of prostate malignant from benign and cancer with high-grade Gleason score (GS) (GS>7) from low-grade GS (GS≤7), 35 patients (24 malignant and 11 benign) who underwent DCE-MRI were included. Difference between malignant and benign was statistically significant for all magnetic resonance parameters except Ve. The cut-off values were K(trans)=0.184min(-1), Kep=0.695min(-1), iAUC=4.219mmol/l/min, and ADC=1340.5mm(2)/s. A significant difference in mean values of K(trans) and Kep between cancer with high-grade GS and low-grade GS was also observed. K(trans) and Kep showed a significant correlation with GS.
authors.affiliation: Department of Radiology, The Catholic University of Korea, Yeouido St. Mary's Hospital, 62, Yeouido-dong, Yeoungdeungpo-gu, Seoul, Korea, 150-713. Electronic address: rukawaek@naver.com.
authors.forename: Eunkyung
authors.initials: E
authors.lastname: Cho
authors.affiliation: Department of Radiology, The Catholic University of Korea, Yeouido St. Mary's Hospital, 62, Yeouido-dong, Yeoungdeungpo-gu, Seoul, Korea, 150-713. Electronic address: bookdoo7@catholic.ac.kr.
authors.forename: Dong Jin
authors.initials: DJ
authors.lastname: Chung
authors.affiliation: Department of Radiology, The Catholic University of Korea, Yeouido St. Mary's Hospital, 62, Yeouido-dong, Yeoungdeungpo-gu, Seoul, Korea, 150-713. Electronic address: duehdaud@gmail.com.
authors.forename: Dong Myung
authors.initials: DM
authors.lastname: Yeo
authors.affiliation: Department of Urology, The Catholic University of Korea, Yeouido St. Mary's Hospital, 62, Yeouido-dong, Yeoungdeungpo-gu, Seoul, Korea, 150-713. Electronic address: 10410281@catholic.ac.kr.
authors.forename: Dongwan
authors.initials: D
authors.lastname: Sohn
authors.affiliation: Imaging and Therapy Systems Division, SIEMENS Healthcare Korea, Poongsan Building 6th Floor, 23, Chungjeong-ro, Seodaemun-gu, Seoul, Korea, 120-714. Electronic address: yohan.son@siemens.com.
authors.forename: Yohan
authors.initials: Y
authors.lastname: Son
authors.affiliation: Department of Pathology, The Catholic University of Korea, Yeouido St. Mary's Hospital, 62, Yeouido-dong, Yeoungdeungpo-gu, Seoul, Korea, 150-713. Electronic address: 10301101@catholic.ac.kr.
authors.forename: Taejung
authors.initials: T
authors.lastname: Kim
authors.affiliation: Department of Radiology, The Catholic University of Korea, Yeouido St. Mary's Hospital, 62, Yeouido-dong, Yeoungdeungpo-gu, Seoul, Korea, 150-713. Electronic address: sthahn52@hanmail.net.
authors.forename: Sung-Tae
authors.initials: ST
authors.lastname: Hahn
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003287:Contrast Media / Q000008:administration & dosage; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading / Q000379:methods*; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D012016:Reference Values; D012039:Regional Blood Flow; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media
keywords: Cut-off value; DCE-MRI; Gleason’s score; Perfusion parameter; Prostate cancer