title: Self-assembly of amphiphilic anionic calix[4]arenes and encapsulation of poorly soluble naproxen and flurbiprofen.
abstract: Supramolecular aggregates formed through the association of an amphiphilic tetra-O-butylsulfonate calix[4]arene 1 were investigated in aqueous solution by a combination of different techniques (NMR, DLS and AFM). The ability of the micellar aggregates of calixarene 1 to increase the solubility of poorly water-soluble drugs was studied.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy. anotti@unime.it ipisagatti@unime.it.
authors.forename: Lucia
authors.initials: L
authors.lastname: Barbera
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gattuso
authors.forename: Franz H
authors.initials: FH
authors.lastname: Kohnke
authors.forename: Anna
authors.initials: A
authors.lastname: Notti
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Pappalardo
authors.forename: Melchiorre F
authors.initials: MF
authors.lastname: Parisi
authors.forename: Ilenia
authors.initials: I
authors.lastname: Pisagatti
authors.forename: Salvatore
authors.initials: S
authors.lastname: Patanè
authors.forename: Norberto
authors.initials: N
authors.lastname: Micali
authors.forename: Valentina
authors.initials: V
authors.lastname: Villari
mesh_terms: D000838:Anions / Q000737:chemistry; D047250:Calixarenes / Q000737:chemistry*; D000067493:Dynamic Light Scattering; D005480:Flurbiprofen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D009288:Naproxen / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D000838:Anions; D008823:Micelles; D013501:Surface-Active Agents; C000605888:p-tert-butylcalix(4)arene tetra-O-butylsulfonate; D047250:Calixarenes; D009288:Naproxen; D005480:Flurbiprofen