title: Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma.
abstract: Increased levels of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide have been reported in many cancer cells and they have been implicated in carcinogenesis and tumor progression. Antioxidant enzymes, such as Manganese Superoxide Dismutase (MnSOD or SOD2) and Glutathione Peroxidase-1 (GPx1), act coordinately to neutralize ROS. These enzymes are also thought to contribute to cancer cell resistance to conventional radio-chemo-therapies. Although some relationships have been reported between psychosocial factors and the regulation of antioxidant enzymes, little is known about these relationships in the context of cancer progression. The current study investigated the levels of MnSOD and GPx1in confirmed serous, high-grade tumor tissue from 60 ovarian cancer patients, and explored the relationship between the activity of these enzymes, the levels of tumor norepinephrine (NE), and patient mood as determined via pre-operative questionnaires. MnSOD activity was positively related to depressed mood (p=0.025) and tumor NE (p=0.023). In contrast, GPx1 activity was inversely related to fatigue (p=0.015) and tumor NE (p=0.009), and was positively associated with vigor (p=0.024). These findings suggest that psychological state and adrenergic signaling are linked with antioxidant enzyme activity in ovarian cancer and may have implications for patient treatments and outcomes.
authors.affiliation: Department of Psychology, University of Iowa, United States.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Bayer
authors.affiliation: Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, United States; Holden Comprehensive Cancer Center, University of Iowa, United States.
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Spitz
authors.affiliation: Carver College of Medicine, University of Iowa, United States.
authors.forename: Desire
authors.initials: D
authors.lastname: Christensen
authors.affiliation: Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, United States; Holden Comprehensive Cancer Center, University of Iowa, United States.
authors.forename: Michael L
authors.initials: ML
authors.lastname: McCormick
authors.affiliation: Department of Pharmacology, University of Iowa, United States.
authors.forename: Donna
authors.initials: D
authors.lastname: Farley
authors.affiliation: Oregon Health and Sciences University, United States.
authors.forename: Koen
authors.initials: K
authors.lastname: DeGeest
authors.affiliation: Department of Pathology, University of Iowa, United States.
authors.forename: Laila
authors.initials: L
authors.lastname: Damoush
authors.affiliation: Department of Psychology, University of Iowa, United States.
authors.forename: Samantha
authors.initials: S
authors.lastname: Aust
authors.affiliation: Departments of Gynecologic Oncology, Cancer Biology, and Center for RNA Interference and Noncoding RNA, University of Texas, M.D. Anderson Cancer Center, United States.
authors.forename: Anil K
authors.initials: AK
authors.lastname: Sood
authors.affiliation: Department of Psychology, University of Iowa, United States; Holden Comprehensive Cancer Center, University of Iowa, United States; Department of Obstetrics and Gynecology, University of Iowa, United States; Department of Urology, University of Iowa, United States. Electronic address: Susan-lutgendorf@uiowa.edu.
authors.forename: Susan K
authors.initials: SK
authors.lastname: Lutgendorf
mesh_terms: D000339:Affect; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000523:psychology*; D013482:Superoxide Dismutase / Q000378:metabolism*; D000094765:Glutathione Peroxidase GPX1
chemical_list: D000975:Antioxidants; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D009638:Norepinephrine; D000094765:Glutathione Peroxidase GPX1; C000722067:GPX1 protein, human
keywords: Antioxidant enzymes; Biobehavioral; Neuroendocrine; Ovarian cancer; Stress