title: Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology.
abstract: Tumor metastasis is a key cause of cancer mortality, and inhibiting migration of cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as targets for pharmacological research of anti-metastatic drugs. This review briefly introduces the multi-function of these two proteins, and discusses the mechanism of how they regulate cell migration and tumor metastasis.
authors.affiliation: State Key Laboratory of Bio-membrane and Membrane Bio-engineering; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Pengli
authors.initials: P
authors.lastname: Zheng
authors.affiliation: State Key Laboratory of Bio-membrane and Membrane Bio-engineering; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Bio-membrane and Membrane Bio-engineering; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Junlin
authors.initials: J
authors.lastname: Teng
authors.affiliation: State Key Laboratory of Bio-membrane and Membrane Bio-engineering; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing 100871, China; Center for Quantitative Biology, Peking University, Beijing 100871, China. Electronic address: chenjg@pku.edu.cn.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D015870:Gene Expression; D006801:Humans; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000503:physiopathology / Q000517:prevention & control*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology
chemical_list: D000970:Antineoplastic Agents; C510527:CALU protein, human; D002135:Calcium-Binding Proteins; C060820:fibulin
keywords: Anti-metastasis; Calumenin; Cell migration; Fibulin-1