title: Comparison of Plaque Burden and Vessel Remodeling in Obstructive Saphenous Vein Graft Lesions as Assessed by Intravascular Ultrasound and Dual-source Computed Tomography.
abstract: OBJECTIVE
  The aim of our study was to compare plaque burden and vessel remodeling of obstructive saphenous vein graft (SVG) lesions as assessed by dual-source computed tomography (DSCT) and intravascular ultrasound (IVUS).
  
  
  METHODS
  Preintervention DSCT examination and IVUS were performed in consecutive patients before percutaneous treatment of the SVG lesion. SVG vessel and lumen areas were measured with use of DSCT and IVUS at the minimal lumen area (MLA) site and at proximal and distal reference sites. Plaque burden was defined as the ratio of plaque and vessel area. Remodeling index was defined as the ratio of the SVG area at the MLA site to the mean reference SVG area.
  
  
  RESULTS
  Twenty-four obstructive SVG lesions were imaged with DSCT and IVUS before stent implantation in 24 patients. The SVG cross-sectional area at the MLA site measured by IVUS and DSCT was similar (17.0±4.5 vs. 17.3±5.3 mm, P=0.6) and well correlated (R=0.77, P<0.001). Similarly, plaque burden and remodeling index assessments did not differ significantly between the 2 imaging modalities (79.0%±4.0% vs. 81.0%±8.0%, P=0.18, and 1.09±0.22 vs. 1.07±0.32, P=0.7 for IVUS vs. DSCT for plaque burden and remodeling, respectively). The correlation between IVUS-assessed and DSCT-assessed plaque burden and remodeling index was moderate to good (R=0.55, P=0.01 and R=0.77, P<0.001, respectively, for plaque burden and remodeling index).
  
  
  CONCLUSIONS
  There is moderate to good correlation between DSCT and IVUS in the assessment of vessel remodeling and plaque burden in obstructive SVG lesions. Noninvasive assessment and monitoring of SVG disease is feasible using DSCT.
authors.affiliation: *Institute of Cardiology, Warsaw, Poland †Cardiovascular Research Foundation, New York, NY.
authors.forename: Michał
authors.initials: M
authors.lastname: Ciszewski
authors.forename: Rafał
authors.initials: R
authors.lastname: Wolny
authors.forename: Jerzy
authors.initials: J
authors.lastname: Pręgowski
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.forename: Mariusz
authors.initials: M
authors.lastname: Kruk
authors.forename: Cezary
authors.initials: C
authors.lastname: Kępka
authors.forename: Jan
authors.initials: J
authors.lastname: Jastrzębski
authors.forename: Lukasz
authors.initials: L
authors.lastname: Kalinczuk
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Chmielak
authors.forename: Maciej
authors.initials: M
authors.lastname: Karcz
authors.forename: Joanna
authors.initials: J
authors.lastname: Zalewska
authors.forename: Marcin
authors.initials: M
authors.lastname: Demkow
authors.forename: Adam
authors.initials: A
authors.lastname: Witkowski
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D058226:Plaque, Atherosclerotic / Q000175:diagnosis*; D012501:Saphenous Vein / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D066253:Vascular Remodeling / Q000502:physiology*