title: Biomaterial based cardiac tissue engineering and its applications.
abstract: Cardiovascular disease is a leading cause of death worldwide, necessitating the development of effective treatment strategies. A myocardial infarction involves the blockage of a coronary artery leading to depletion of nutrient and oxygen supply to cardiomyocytes and massive cell death in a region of the myocardium. Cardiac tissue engineering is the growth of functional cardiac tissue in vitro on biomaterial scaffolds for regenerative medicine application. This strategy relies on the optimization of the complex relationship between cell networks and biomaterial properties. In this review, we discuss important biomaterial properties for cardiac tissue engineering applications, such as elasticity, degradation, and induced host response, and their relationship to engineered cardiac cell environments. With these properties in mind, we also emphasize in vitro use of cardiac tissues for high-throughput drug screening and disease modelling.
authors.affiliation: Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, Canada. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
authors.forename: Locke Davenport
authors.initials: LD
authors.lastname: Huyer
authors.forename: Miles
authors.initials: M
authors.lastname: Montgomery
authors.forename: Yimu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yun
authors.initials: Y
authors.lastname: Xiao
authors.forename: Genevieve
authors.initials: G
authors.lastname: Conant
authors.forename: Anastasia
authors.initials: A
authors.lastname: Korolj
authors.forename: Milica
authors.initials: M
authors.lastname: Radisic
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000628:therapy; D018929:Cell Culture Techniques; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D006321:Heart / Q000502:physiology*; D006801:Humans; D008422:Materials Testing; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology; D011091:Polyesters; D044968:Regenerative Medicine / Q000379:methods; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters