title: Changing the calculus of pediatric product development: narrowing the too-big gap between need and solution in a small market.
abstract: First, Deliece Hofen drops the pill into hot water to soften the outside coating. Then, she slices through the center of the pill with an X-ACTO knife and squeezes the isotretinoin inside into a syringe. With the drug in liquid form, she can now administer it to her ten-year-old son Brandon. ?The problem is...some of [the isotretinoin] is still left inside of the capsule and I?m not getting an exact dosage,? admits Hofen.
authors.forename: Sarah
authors.initials: S
authors.lastname: Campbell
mesh_terms: D001698:Biomedical Engineering; D002648:Child; D004864:Equipment and Supplies / Q000592:standards*; D006801:Humans; D010372:Pediatrics; D004364:Pharmaceutical Preparations / Q000592:standards*
chemical_list: D004364:Pharmaceutical Preparations