title: Increased plasmacytoid dendritic cells in Guillain-Barré syndrome.
abstract: Guillain-Barré syndrome (GBS) is a post-infectious autoimmune disease. Dendritic cells (DCs) can recognize the pathogen and modulate the host immune response. Exploring the role of DCs in GBS will help our understanding of the disease development. In this study, we aimed to analyze plasmacytoid and conventional DCs in peripheral blood of patients with GBS at different stages of the disease: acute phase as well as early and late recovery phases. There was a significant increase of plasmacytoid DCs in the acute phase (p=0.03 vs healthy donors). There was a positive correlation between percentage of plasmacytoid DCs and the clinical severity of patients with GBS (r=0.61, p<0.001). Quantitative polymerase chain reaction and flow cytometry confirmed the aberrant plasmacytoid DCs in GBS. Thus, plasmacytoid DCs may participate in the development of GBS.
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, PR China; Central Laboratory, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, PR China.
authors.forename: Yu-Zhong
authors.initials: YZ
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, PR China.
authors.forename: Xun-Gang
authors.initials: XG
authors.lastname: Feng
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, PR China.
authors.forename: Chun-Ye
authors.initials: CY
authors.lastname: Xing
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, PR China.
authors.forename: Qi-Guang
authors.initials: QG
authors.lastname: Shi
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, PR China.
authors.forename: Qing-Xia
authors.initials: QX
authors.lastname: Kong
authors.affiliation: Department of Haemotology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, PR China.
authors.forename: Pan-Pan
authors.initials: PP
authors.lastname: Cheng
authors.affiliation: Department of Neurology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Affiliated Hospital of Jining Medical College, Jining, Shandong Province, PR China. Electronic address: yanleihao301@live.com.
authors.forename: Yan-Lei
authors.initials: YL
authors.lastname: Hao
authors.affiliation: Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: mdcyuki@nus.edu.sg.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D003289:Convalescence; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D005732:Gangliosides / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010951:Plasma Exchange; D012720:Severity of Illness Index; D051199:Toll-Like Receptor 7 / Q000096:biosynthesis / Q000235:genetics; D051217:Toll-Like Receptor 9 / Q000096:biosynthesis / Q000235:genetics; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D001323:Autoantibodies; D001324:Autoantigens; D005732:Gangliosides; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; C495348:TLR7 protein, human; C495371:TLR9 protein, human; D051199:Toll-Like Receptor 7; D051217:Toll-Like Receptor 9
keywords: Dendritic cell; Guillain–Barré syndrome