title: Asymmetric cell division of granule neuron progenitors in the external granule layer of the mouse cerebellum.
abstract: The plane of division of granule neuron progenitors (GNPs) was analysed with respect to the pial surface in P0 to P14 cerebellum and the results showed that there was a significant bias towards the plane of cell division being parallel to pial surface across this developmental window. In addition, the distribution of β-Catenin in anaphase cells was analysed, which showed that there was a significant asymmetry in the distribution of β-Catenin in dividing GNPs. Further, inhibition of Sonic Hedgehog (Shh) signalling had an effect on plane of cell division. Asymmetric distribution of β-Catenin was shown to occur towards the source of a localized extracellular cue.
authors.affiliation: National Brain Research Centre, Manesar, Gurgaon 122050, Haryana, India.
authors.forename: Parthiv
authors.initials: P
authors.lastname: Haldipur
authors.affiliation: Centre for Neuroscience, Indian Institute of Science, Bangalore 560012, Karnataka, India.
authors.forename: Iswariya
authors.initials: I
authors.lastname: Sivaprakasam
authors.affiliation: National Brain Research Centre, Manesar, Gurgaon 122050, Haryana, India.
authors.forename: Vinod
authors.initials: V
authors.lastname: Periasamy
authors.affiliation: Centre for Neuroscience, Indian Institute of Science, Bangalore 560012, Karnataka, India.
authors.forename: Subashika
authors.initials: S
authors.lastname: Govindan
authors.affiliation: Centre for Neuroscience, Indian Institute of Science, Bangalore 560012, Karnataka, India shyamala@cns.iisc.ernet.in.
authors.forename: Shyamala
authors.initials: S
authors.lastname: Mani
keywords: Cell division; Cerebellum; Sonic hedgehog; β-Catenin