title: The Role of α-Synuclein and LRRK2 in Tau Phosphorylation.
abstract: There is now a considerable body of experimental evidence that Parkinson's disease arises through physiological interaction of causative molecules, leading to tau pathology. In this review, we discuss the physiological role of α-synuclein and LRRK2 in the abnormal phosphorylation of tau. In addition, as recent reports have indicated that heat shock proteins- (HSPs-) inducing drugs can help to ameliorate neurodegenerative diseases associated with tau pathology, we also discuss therapeutic strategies for PD focusing on inhibition of α-synuclein- and LRRK2-associated tau phosphorylation by HSPs.
authors.affiliation: Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 2520373, Japan.
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Kawakami
authors.affiliation: Department of Regulation Biochemistry, Graduate School of Medical Sciences, Kitasato University, Sagamihara 2520373, Japan.
authors.forename: Takafumi
authors.identifier: 0000-0001-5287-2562
authors.initials: T
authors.lastname: Ichikawa