title: Soluble receptor of advanced glycation end-products in patients with acute myocardial infarction treated with remote ischaemic conditioning.
abstract: BACKGROUND
  Several studies have demonstrated that soluble receptor of advanced glycation end-products (sRAGE) is a valuable inflammatory biomarker in cardiovascular disease (CVD). Remote ischaemic conditioning may rescue myocardial tissue during acute myocardial infarction (AMI). In the present study, we evaluate whether sRAGE is a helpful biomarker in patients with AMI receiving remote ischaemic conditioning.
  
  
  METHODS
  Plasma sRAGE levels were measured in 191 patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous intervention (pPCI) of which 97 patients were randomised to receive remote ischaemic conditioning.
  
  
  RESULTS
  The sRAGE levels were not different when compared to the randomised controls. In 122 patients, measurement of myocardial salvage index (SI) was obtained. Patients who received remote ischaemic conditioning had significantly higher SI compared to the controls (p < 0.03), although this effect was not seen in sRAGE concentrations. However, sRAGE levels increased with higher New York Heart Association (NYHA) classification after 30 days of follow-up.
  
  
  CONCLUSIONS
  sRAGE levels do not reflect increased SI in AMI patients who received remote ischaemic conditioning prior to hospital admission.
authors.forename: Louise Jung Nørgaard
authors.initials: LJ
authors.lastname: Jensen
authors.forename: Kim
authors.initials: K
authors.lastname: Munk
authors.forename: Allan
authors.initials: A
authors.lastname: Flyvbjerg
authors.forename: Hans Erik
authors.initials: HE
authors.lastname: Bøtker
authors.forename: Mette
authors.initials: M
authors.lastname: Bjerre
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood; D019411:Clinical Laboratory Techniques; D005260:Female; D006801:Humans; D007249:Inflammation; D007511:Ischemia / Q000473:pathology*; D019194:Ischemic Preconditioning; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D062645:Percutaneous Coronary Intervention; D011379:Prognosis; D011446:Prospective Studies; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*
chemical_list: D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic