title: Pathogenesis and potential therapeutic targets in systemic lupus erythematosus: from bench to bedside.
abstract: Systemic lupus erythematosus (SLE) is considered an autoimmune disease with multiorgan involvement. Many advances have been made during the last decade regarding inflammatory pathways, genetic and epigenetic alterations, adaptive and innate immune system mechanisms specifically involved in SLE pathogenesis. Apoptosis has been proposed as an important player in SLE pathogenesis more than a decade ago. However, only recently new key apoptotic pathways have been investigated and the link between apoptotic debris containing autoantigens, innate immunity and ongoing inflammation has been further elucidated. Better understanding of cellular mechanisms and involved cytokines contributed to the development of new biological drugs specifically addressed for SLE therapy.
authors.affiliation: SOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Squatrito
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Emmi
authors.affiliation: SOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Silvestri
authors.affiliation: SOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Ciucciarelli
authors.affiliation: SOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
authors.forename: M M
authors.initials: MM
authors.lastname: D'Elios
authors.affiliation: SOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy ; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Prisco
authors.affiliation: SOD Patologia Medica, Center for Autoimmune Systemic Diseases, Behçet Center and Lupus Clinic, AOU Careggi, Florence, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Emmi
keywords: Apoptosis in SLE; Autoantibodies; Autoimmune diseases; Biologic therapies; Systemic lupus erythematosus