title: Bone-immune cell crosstalk: bone diseases.
abstract: Bone diseases are associated with great morbidity; thus, the understanding of the mechanisms leading to their development represents a great challenge to improve bone health. Recent reports suggest that a large number of molecules produced by immune cells affect bone cell activity. However, the mechanisms are incompletely understood. This review aims to shed new lights into the mechanisms of bone diseases involving immune cells. In particular, we focused our attention on the major pathogenic mechanism underlying periodontal disease, psoriatic arthritis, postmenopausal osteoporosis, glucocorticoid-induced osteoporosis, metastatic solid tumors, and multiple myeloma.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Mori
authors.affiliation: Department of Medical Science, Section of Gerontology and Bone Metabolism Diseases, University of Torino, 10126 Torino, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: D'Amelio
authors.affiliation: Department of Orthopedics, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Roberta
authors.initials: R
authors.lastname: Faccio
authors.affiliation: Department of Basic Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy.
authors.forename: Giacomina
authors.identifier: 0000-0002-0681-1432
authors.initials: G
authors.lastname: Brunetti
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D015519:Bone Density / Q000276:immunology; D001847:Bone Diseases / Q000276:immunology* / Q000473:pathology*; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000276:immunology / Q000473:pathology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016207:Cytokines