title: The glycobiology of the CD system: a dictionary for translating marker designations into glycan/lectin structure and function.
abstract: The profile of cell surface molecules, the biochemical platform for cellular communication, can be likened to a molecular fingerprint. Historically, raising monoclonal antibodies by immunization with cells has been instrumental in obtaining tools suited for phenotyping and functional analysis. Initially for leukocyte antigens, the resulting cluster of differentiation (CD) nomenclature has become a popular system for classification. Glycans presented on proteins or lipids and receptors for carbohydrate structures (lectins) are part of the CD list. Our review presents biochemical and biomedical highlights of the respective CD entries.
authors.affiliation: Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Veterinärstraße 13, 80539 Munich, Germany. Electronic address: gabius@tiph.vetmed.uni-muenchen.de.
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Gabius
authors.affiliation: Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Veterinärstraße 13, 80539 Munich, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Kaltner
authors.affiliation: Institute of Pathology, Department of Applied Tumor Biology, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kopitz
authors.affiliation: Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Veterinärstraße 13, 80539 Munich, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: André
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000378:metabolism*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006031:Glycosylation; D006801:Humans; D037102:Lectins; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary
chemical_list: D015703:Antigens, CD; D037102:Lectins; D011134:Polysaccharides