title: PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant.
abstract: Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infections among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patients' risk stratification.
authors.affiliation: Infectious Diseases Service, University Hospital and University of Lausanne.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wójtowicz
authors.affiliation: Service of Transplantation and Service of Infectious Diseases, University Hospitals of Geneva.
authors.forename: T Doco
authors.initials: TD
authors.lastname: Lecompte
authors.affiliation: Infectious Diseases Service, University Hospital and University of Lausanne.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Bibert
authors.affiliation: Infectious Diseases Service, University Hospital and University of Lausanne Transplantation Center, Department of Surgery.
authors.forename: Oriol
authors.initials: O
authors.lastname: Manuel
authors.affiliation: Institute of Social and Preventive Medicine, University Hospital and University of Lausanne Swiss Institute of Bioinformatics, Lausanne.
authors.forename: Sina
authors.initials: S
authors.lastname: Rüeger
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zürich.
authors.forename: Christoph
authors.initials: C
authors.lastname: Berger
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen.
authors.forename: Katia
authors.initials: K
authors.lastname: Boggian
authors.affiliation: Department of Infectious Diseases, Inselspital, Bern University Hospital and University of Bern.
authors.forename: Alexia
authors.initials: A
authors.lastname: Cusini
authors.affiliation: Department of Infectious Diseases, Inselspital, Bern University Hospital and University of Bern Departments of Internal Medicine and Infectious Disease, Clinica Luganese, Lugano.
authors.forename: Christian
authors.initials: C
authors.lastname: Garzoni
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel.
authors.forename: Hans
authors.initials: H
authors.lastname: Hirsch
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Basel.
authors.forename: Nina
authors.initials: N
authors.lastname: Khanna
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zürich.
authors.forename: Nicolas J
authors.initials: NJ
authors.lastname: Mueller
authors.affiliation: Infectious Diseases Service, University Hospital and University of Lausanne Institute of Microbiology, University Hospital and University of Lausanne, Switzerland.
authors.forename: Pascal R
authors.initials: PR
authors.lastname: Meylan
authors.affiliation: Transplantation Center, Department of Surgery.
authors.forename: Manuel
authors.initials: M
authors.lastname: Pascual
authors.affiliation: Service of Transplantation and Service of Infectious Diseases, University Hospitals of Geneva.
authors.forename: Christian
authors.initials: C
authors.lastname: van Delden
authors.affiliation: Infectious Diseases Service, University Hospital and University of Lausanne.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Bochud
mesh_terms: D002097:C-Reactive Protein / Q000235:genetics*; D005260:Female; D005658:Fungi / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009181:Mycoses / Q000235:genetics* / Q000276:immunology*; D016377:Organ Transplantation / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D000683:Serum Amyloid P-Component / Q000235:genetics*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D000099153:Pentraxins
keywords: PTX3; SNP; genetic susceptibility; innate immunity; solid organ transplant