title: Evaluation of the protective effect of Pterocarpus marsupium on acetic acid-induced ulcerative colitis in rats.
abstract: The aim of the study was to evaluate the effect of Pterocarpus marsupium (PM) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. The rats were divided into five groups, each having six rats. PM extract 100 mg and 200 mg/kg was given orally to groups four and five, respectively, and standard drug sulfasalazine (100 mg/kg, p.o) to group three. Group two served as UC control animals, and group one control animals received vehicle for 7 days. UC was induced by administering AA (3 % v/v of 2 ml) to all the animals except group one. After 72 h, the animals were killed and the colon was dissected out for microscopic, clinical evaluation, histopathological study and biochemical estimation. PM (100 and 200 mg/kg)-treated group had significantly reduced colon inflammation and mucosal damage. The treatment also normalized the altered antioxidant enzyme levels (LPO, SOD and GSH). Histopathological studies support the effect. The protective effect of PM may be due to antiinflammatory and antioxidant properties.
authors.affiliation: Department of Pharmacology, PSG College of Pharmacy, PO BOX NO 1674, Peelamedu, Coimbatore, 641004, Tamilnadu, India.
authors.forename: Merin Maria
authors.initials: MM
authors.lastname: Mathew
authors.forename: Nguyen Vinh
authors.initials: NV
authors.lastname: Han
authors.forename: A
authors.initials: A
authors.lastname: Murugesan
authors.forename: E Arun
authors.initials: EA
authors.lastname: Raj
authors.forename: K G
authors.initials: KG
authors.lastname: Prasanth
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D035721:Pterocarpus / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012460:Sulfasalazine / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts; D012460:Sulfasalazine; D019342:Acetic Acid