title: Tumor-Targeting Co-Delivery of Drug and Gene from Temperature-Triggered Micelles.
abstract: Co-delivery strategy using multifunctional nanocarriers is an attractive option for the synergistic and enhanced effects in cancer treatment, but one system integrating multiple functions for controlled release at the target is still challenging. Herein, this study shows the synthesis and characterization of our stimulus-responsive co-delivery system for the controlled release into tumors, which is composed of polyethylenimine (PEI)-linked Pluronic F127 (PF127) and folic acid (FA), called PF127-PEI-FA. PF127-PEI-FA system facilitated drug loading and gene complex formation, and showed controlled release behaviors in response to hitting temperature to hyperthermia. PF127-PEI-FA system was demonstrated to be biocompatible and showed receptor-mediated gene delivery. The results of our multifunctional nanocarrier system that enabled co-delivery suggest a promising potential for controlled drug release at targeted areas. However, further in-depth studies on the use of therapeutic drugs and genes in multiple cell types and the animal response are required.
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 330-714, Republic of Korea. seosj203@dankook.ac.kr.|Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 330-714, Republic of Korea. seosj203@dankook.ac.kr.
authors.forename: Seog-Jin
authors.initials: SJ
authors.lastname: Seo
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 330-714, Republic of Korea.|Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 330-714, Republic of Korea.
authors.forename: Seon-Young
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 330-714, Republic of Korea.|Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 330-714, Republic of Korea.
authors.forename: Seong-Jun
authors.initials: SJ
authors.lastname: Choi
authors.affiliation: Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 330-714, Republic of Korea. kimhw@dku.edu.|Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 330-714, Republic of Korea. kimhw@dku.edu.|Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan, 330-714, Republic of Korea. kimhw@dku.edu.
authors.forename: Hae-Won
authors.initials: HW
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004337:Drug Carriers; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D018014:Gene Transfer Techniques; D006367:HeLa Cells; D006801:Humans; D008823:Micelles; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D020442:Poloxamer; D011094:Polyethyleneimine / Q000031:analogs & derivatives* / Q000737:chemistry; D013696:Temperature; D019076:Transgenes
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; C582285:Pluronic F127-polyethylenimine-folate copolymer; D020442:Poloxamer; D011094:Polyethyleneimine; D005492:Folic Acid
keywords: folic acid; pluronic F127; polyethylenimine; temperature trigger; tumor-targeting nanocarrier