title: The Return of Delayed-Type Hypersensitivity Skin Testing for Coccidioidomycosis.
abstract: A skin test that detects dermal hypersensitivity in persons with past infection with Coccidioides species is again available for clinical use. Nearly all of the clinical studies with similar materials were published prior to the 1990s, and as a result, many practicing physicians will be unfamiliar with how skin testing for coccidioidomycosis might be useful in patient management or as a research tool. We review clinical and epidemiological studies with past skin test antigens, the composition of past and current skin test preparations with particular attention to differences in the preservatives, and how the current preparation could be used today.
authors.affiliation: Valley Fever Center for Excellence.
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Wack
authors.affiliation: University of Arizona College of Medicine Southern Arizona Veterans Affairs Health Care System, Tucson.
authors.forename: Neil M
authors.initials: NM
authors.lastname: Ampel
authors.affiliation: Maricopa County Department of Health, Phoenix, Arizona Centers for Disease Control and Prevention, Atlanta, Georgia.
authors.forename: Rebecca H
authors.initials: RH
authors.lastname: Sunenshine
authors.affiliation: Valley Fever Center for Excellence University of Arizona College of Medicine.
authors.forename: John N
authors.initials: JN
authors.lastname: Galgiani
mesh_terms: D000946:Antigens, Fungal / Q000276:immunology; D003046:Coccidioidin / Q000276:immunology; D003047:Coccidioidomycosis / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D009172:Mycology; D012882:Skin Tests / Q000379:methods*
chemical_list: D000946:Antigens, Fungal; C009303:spherulin; D003046:Coccidioidin
keywords: cellular immunity; coccidioidomycosis; delayed type hypersensitivity; diagnostic test; skin test