title: Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics.
abstract: Metformin is a commonly prescribed diabetes medication whose mechanism of action is poorly understood. In this study we utilized EHR-linked biobank data to elucidate the impact of genomic variation on glycemic response to metformin. Our study found significant gene- and SNP-level associations within the beta-2 subunit of the heterotrimeric adenosine monophosphate-activated protein kinase complex. Using EHR phenotypes where were able to add additional clarity to ongoing metformin pharmacogenomic dialogue.
authors.affiliation: Mayo Clinic, Department of Health of Sciences Research.
authors.forename: Matthew K
authors.initials: MK
authors.lastname: Breitenstein
authors.affiliation: University of Minnesota, Institute for Health Informatics.
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Simon
authors.affiliation: Mayo Clinic, Department of Health of Sciences Research.
authors.forename: Euijung
authors.initials: E
authors.lastname: Ryu
authors.affiliation: Mayo Clinic, Department of Health of Sciences Research.
authors.forename: Sebastian M
authors.initials: SM
authors.lastname: Armasu
authors.affiliation: Mayo Clinic, Department of Molecular Pharmacology and Experimental Therapeutics.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Weinshilboum
authors.affiliation: Mayo Clinic, Department of Molecular Pharmacology and Experimental Therapeutics.
authors.forename: Liewei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Mayo Clinic, Department of Health of Sciences Research.
authors.forename: Jyotishman
authors.initials: J
authors.lastname: Pathak
mesh_terms: D018070:Biological Specimen Banks / Q000458:organization & administration*; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000235:genetics*; D057286:Electronic Health Records / Q000458:organization & administration*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D016247:Information Storage and Retrieval / Q000379:methods; D008498:Medical Record Linkage / Q000379:methods; D008687:Metformin / Q000627:therapeutic use*; D008910:Minnesota; D010597:Pharmacogenetics / Q000379:methods / Q000458:organization & administration*; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin