title: Future opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate (Review).
abstract: Caffeic acid phenethyl ester (CAPE) is an important active component of propolis, which is derived from honeybee hives. It has received increasing attention in a variety of medical and pharmaceutical research, due to its anti‑oxidant, antiproliferative, anti‑inflammatory, antiviral and antifungal activity, in addition to its antineoplastic properties. Besides the use of CAPE as an antioxidant and anti‑inflammatory agent in a number of in vivo studies of ear disease, its beneficial effects have been reported in the treatment of cancer, arthritis, allergies, heart disease, diabetes, kidney disease, liver disease and neurological disease. CAPE influences a number of biochemical pathways, as well as several targets involved in ear diseases, in particular, in ototoxicity. The protective effects of CAPE in ototoxicity, which may be induced by a number factors, including lipopolysaccharides, hydrogen peroxide and streptomycin, are evaluated and discussed in the present review.
authors.affiliation: Department of Medical Biology, Medical Faculty, Turgut Ozal University, Ankara 06170, Turkey.
authors.forename: Sumeyya
authors.initials: S
authors.lastname: Akyol
authors.affiliation: Department of Family Medicine, Medical Faculty, Hacettepe University, Ankara 06100, Turkey.
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Isik
authors.affiliation: Division of Chemistry, Ankara Regional Office of Council of Forensic Medicine, Ankara 06300, Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Altuntas
authors.affiliation: Department of Medical Biochemistry, Medical Faculty, Hacettepe University, Ankara 06100, Turkey.
authors.forename: Gonul
authors.initials: G
authors.lastname: Erden
authors.affiliation: Department of Biology, Faculty of Education, Gazi University, Ankara 06500, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Cakmak
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Adnan Menderes University, Aydin 09100, Turkey.
authors.forename: S Fatih
authors.initials: SF
authors.lastname: Kurşunlu
authors.affiliation: San Jose State University, San Jose 95101, CA, USA.
authors.forename: Bahattin
authors.initials: B
authors.lastname: Adam
authors.affiliation: Division of Chemistry, Ankara Regional Office of Council of Forensic Medicine, Ankara 06300, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Akyol
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use*; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use*; D002109:Caffeic Acids / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D063371:Myringosclerosis / Q000188:drug therapy*; D010033:Otitis Media / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D011429:Propolis / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D002109:Caffeic Acids; D011429:Propolis; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol