title: Symbiotic and antibiotic interactions between gut commensal microbiota and host immune system.
abstract: The human gut commensal microbiota forms a complex population of microorganisms that survive by maintaining a symbiotic relationship with the host. Amongst the metabolic benefits it brings, formation of adaptive immune system and maintenance of its homeostasis are functions that play an important role. This review discusses the integral elements of commensal microbiota that stimulate responses of different parts of the immune system and lead to health or disease. It aims to establish conditions and factors that contribute to gut commensal microbiota's transformation from symbiotic to antibiotic relationship with human. We suggest that the host-microbiota relationship has been evolved to benefit both parties and any changes that may lead to disease, are not due to unfriendly properties of the gut microbiota but due to host genetics or environmental changes such as diet or infection.
authors.affiliation: St Catherine's College, University of Oxford, Oxford OX1 3UJ, UK. Electronic address: mantasmalys@yahoo.co.uk.
authors.forename: Mantas Kazimieras
authors.initials: MK
authors.lastname: Malys
authors.affiliation: School of Life Sciences, Gibbet Hill Campus, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Campbell
authors.affiliation: School of Life Sciences, Gibbet Hill Campus, University of Warwick, Coventry CV4 7AL, UK. Electronic address: n.malys@gmail.com.
authors.forename: Naglis
authors.initials: N
authors.lastname: Malys
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000276:immunology; D004032:Diet; D000069196:Gastrointestinal Microbiome / Q000187:drug effects* / Q000235:genetics / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D006706:Homeostasis; D006801:Humans; D007107:Immune System / Q000382:microbiology*; D007070:Immunoglobulin A / Q000276:immunology; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D007070:Immunoglobulin A
keywords: B-cells; Commensal microbiota; Dysbiosis; Immune system; T-cells