title: Study of digoxin use in a public health unit.
abstract: Digoxin is used for heart failure associated to systolic dysfunction and high ventricular rate. It has a narrow therapeutic range and intoxication may occur due to drug interactions or comorbidities. The aim of this work was to study digoxin use in a public health unit delineating the profile of patients susceptible to digitalis intoxication. Medical records belonging to patients admitted to the cardiomyopathy ward of the health unit (2009-2010) and in use of digoxin were analyzed. Among 647 patients admitted, 185 individuals using digoxin and possessed records available. The registration of plasma digoxin concentration was found in 80 records and it was out of the therapeutic range in 42 patients (52.5%). This group of individuals was constituted mainly by males patients (79%), functional class III of heart failure (65%), exhibiting renal failure (33%). The evaluated sample reflects the epidemiology of heart failure in Brazil and, although pharmacotherapy had been according to Brazilian Guidelines, apparently the monitoring was not performed as recommended. This work highlighs the necessity of plasma digoxin constant monitoring during pharmacotherapy and the development of protocols that enable a safer use, especially in male patients, functional class III and with renal dysfunction.
authors.affiliation: Departamento de Fisiologia e Farmacologia (, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brasil.
authors.forename: Felipe C
authors.initials: FC
authors.lastname: Souza
authors.affiliation: Departamento de Fisiologia e Farmacologia (, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brasil.
authors.forename: Emiliana B
authors.initials: EB
authors.lastname: Marques
authors.forename: Rogério B M
authors.initials: RB
authors.lastname: Scaramello
authors.affiliation: Departamento de Fisiologia e Farmacologia (, Instituto Biomédico, Universidade Federal Fluminense, Niterói, RJ, Brasil.
authors.forename: B V
authors.initials: BV
authors.lastname: Christianne
mesh_terms: D000328:Adult; D001938:Brazil; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D004077:Digoxin / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011634:Public Health; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D002316:Cardiotonic Agents; D004077:Digoxin