title: Polydatin administration improves serum biochemical parameters and oxidative stress markers during chronic alcoholism: a pilot study.
abstract: OBJECTIVE
  Polydatin, a hydroxystilbene derived from the rhizome of Polygonum cuspidatum, elicits hepatoprotective and neuroprotective effects through its anti-oxidant properties. The present study aimed to determine the effects of oral administration of polydatin in alcoholic patients in order to improve liver biochemical parameters, serum oxidative stress and mental state. We enrolled 20 chronic alcoholic patients hospitalized for rehabilitative therapy. The patients were divided into two groups receiving the following treatment regimes for two weeks: administration of an anti-oxidant nutritional supplement containing glutathione and vitamin C (group 1), or glutathione, vitamin C and polydatin (group 2).
  
  
  RESULTS
  The results of the present study show that elevated plasma aspartate aminotransferase and alanine aminotransferase levels in patients after two weeks of alcohol withdrawal were significantly reduced by polydatin (group 2), when compared to group 1. Polydatin also significantly reduced lipid peroxidation levels. Finally, our preliminary data resulting from the analysis of the Mini-Mental Status suggest that polydatin improves cognitive performance.
  
  
  CONCLUSIONS
  Daily dietary administration of polydatin should be considered for prevention and treatment of liver disease and cognitive impairment in alcoholic patients.
authors.affiliation: Department of Anesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy.
authors.forename: Maria Caterina
authors.initials: MC
authors.lastname: Pace
authors.affiliation: Department of Anesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy.
authors.forename: Maria Beatrice
authors.initials: MB
authors.lastname: Passavanti
authors.affiliation: Department of Anesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Aurilio
authors.affiliation: Department of Anesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Sansone
authors.affiliation: Department of Anesthesiological, Surgical and Emergency Sciences, Second University of Naples, Naples, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Aurilio
authors.affiliation: Department of Operative Units-Naples GLURES srl, Second University of Naples, Naples, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: DE Maria
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Lama
authors.affiliation: Department of Clinical and Experimental Medicine, Second University of Naples, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Federico
authors.affiliation: Department of Operative Units-Naples GLURES srl, Second University of Naples, Naples, Italy.
authors.forename: Gianpietro
authors.initials: G
authors.lastname: Ravagnan
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy Michele.caraglia@unina2.it paola.stiuso@unina2.it.
authors.forename: Michele
authors.initials: M
authors.lastname: Caraglia
authors.affiliation: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy Michele.caraglia@unina2.it paola.stiuso@unina2.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Stiuso
mesh_terms: D000437:Alcoholism / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D000975:Antioxidants / Q000008:administration & dosage*; D016022:Case-Control Studies; D005960:Glucosides / Q000008:administration & dosage*; D006801:Humans; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D013267:Stilbenes / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D005960:Glucosides; D013267:Stilbenes; C058229:polydatin
keywords: Polydatin; alcohol; lipid peroxidation; liver injury; oxidative stress