title: [Associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients].
abstract: The study aims to investigate the associations of SUMO4 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients. Blood samples and clinical data were collected from 132 renal transplant recipients with tacrolimus treatment. CYP3A5*3 genotypes were detected by PCR-RFLP, and SUMO4 (rs237024, rs237025) genotypes were detected by Sequenom® MassARRAY system. SUMO4 rs237024 and rs237025 genotypes were in complete linkage disequilibrium (D' = 1). The dose-adjusted concentration of tacrolimus in SUMO4 rs237024A-rs237025A (GA-GA +AA-AA) carriers was considerably higher than that in GG-GG carriers (P < 0.05). After stratification by CYP3A5*3 genotypes, SUMO4 rs237024A-rs237025A carriers (GA-GA+AA-AA) had a higher dose-adjusted tacrolimus concentration than that in GG carriers in CYP3A5 expresser (P < 0.05). The results illustrated that SUMO4 rs237024 and rs237025 polymorphisms were associated with tacrolimus concentrations, and the test of these genotypes may be useful for individualized medicine of tacrolimus.
authors.forename: Xiao-Man
authors.initials: XM
authors.lastname: Liu
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Li
authors.forename: Hong-Yang
authors.initials: HY
authors.lastname: Wang
authors.forename: Qian
authors.initials: Q
authors.lastname: Fu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.lastname: Liu Shu
authors.forename: Ping-Ping
authors.initials: PP
authors.lastname: Sun
authors.forename: Chang-Xi
authors.initials: CX
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Huang
mesh_terms: D044466:Asian People / Q000235:genetics; D051544:Cytochrome P-450 CYP3A / Q000235:genetics; D005838:Genotype; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood* / Q000627:therapeutic use; D007668:Kidney; D016030:Kidney Transplantation; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D025841:Small Ubiquitin-Related Modifier Proteins / Q000235:genetics*; D016559:Tacrolimus / Q000097:blood* / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; C489647:SUMO4 protein, human; D025841:Small Ubiquitin-Related Modifier Proteins; C510164:CYP3A5 protein, human; D051544:Cytochrome P-450 CYP3A; D016559:Tacrolimus