title: Curcumin alleviates cisplatin-induced learning and memory impairments.
abstract: The present study has been designed to investigate the role of curcumin on cisplatin-inducedcognitive impairment and to reveal mechanisms of cisplatin's detrimental actions on cognition in rats. Animals were treated with cisplatin (5mg/kg/week) and/or curcumin (300mg/kg/day) for 5weeks. Morris water maze test was used to assess spatial learning and memory. Enzymatic activities of acetylcholinesterase (AChE) and superoxide dismutase (SOD) were evaluated from hippocampus and plasma samples, and malondialdehyde (MDA), which is the end-product of lipid peroxidation, was determined by a colorimetric method. Our results showed that cisplatin (5mg/kg/week, 5weeks) caused learning and memory deficits, elevated MDA content, decreased SOD activity in the hippocampus and plasma, and AChE activity in the hippocampus. Curcumin improved learning and memory in rats with administration of cisplatin. In addition, curcumin significantly reduced the level of MDA and increased the activities of SOD and AChE. Taken together, our findings indicate that curcumin ameliorates cisplatin-induced spatial learning and memory impairment, possibly through restored cholinergic function and enhanced oxidative status.
authors.affiliation: School of Health Services, Mevlana (Rumi) University, Konya, Turkey. Electronic address: ozmhmt@gmail.com.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Oz
authors.affiliation: Department of Pharmacology, Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: K Esra
authors.initials: KE
authors.lastname: Nurullahoglu Atalik
authors.affiliation: Department of Biochemistry, Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey.
authors.forename: F Humeyra
authors.initials: FH
authors.lastname: Yerlikaya
authors.affiliation: Department of Physiology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Enver Ahmet
authors.initials: EA
authors.lastname: Demir
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D003072:Cognition Disorders / Q000139:chemically induced / Q000188:drug therapy*; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis*; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D065852:Spatial Memory / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D018696:Neuroprotective Agents; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000110:Acetylcholinesterase; D003474:Curcumin; D002945:Cisplatin
keywords: AChE; Cisplatin; Curcumin; Learning and memory; Oxidative status