title: Stroke etiology is associated with outcome in posterior circulation stroke.
abstract: OBJECTIVE
  Stroke research and clinical trials have focused mainly on anterior circulation stroke (ACS). Since clinical characteristics, mechanisms, and outcomes of posterior circulation stroke (PCS) have been reported different from ACS, more PCS studies are required, particularly researching the etiologies, to help establish an optimal management strategy.
  
  
  METHODS
  The present study analyzed patients of PCS who were consecutively admitted and registered in Taipei Veterans General Hospital Stroke Registry between 1 January 2012 to 28 February 2014. We demonstrated the distribution of etiologies, compared the clinical characteristics/outcomes among different etiology groups, and used univariate/multivariate analyses to identify the predictors for poor functional outcome (modified Rankin Scale ≥5) at discharge and 3 month.
  
  
  RESULTS
  About 286 patients of PCS were included for analyses. Basilar artery atheromatous branch occlusive disease (BABO, 28.0%) and large artery dissection (25.9%) were the two most common etiologies, followed by large artery atherosclerotic stenosis/occlusion (LAA, 20.6%), cardioembolism (CE, 18.5%) and small vessel disease (7.0%). Age, vascular risk factors, infarct locations and patterns, and outcomes were different among these five etiology groups. Multivariate analyses showed that age >70 y/o (discharge/3 month, OR, 95% CI: 3.05, 1.23-7.56/8.39, 2.32-30.33), admission NIH Stroke Scale >9 (19.50, 8.69-43.75/13.45, 5.59-32.39), and etiology (LAA versus BABO: 5.00, 1.58-15.83/4.00, 1.19-13.4; CE versus BABO: 3.36, 1.02-11.09/4.66, 1.40-15.46) were independently associated with poor functional outcome.
  
  
  CONCLUSIONS
  The etiologies of PCS are heterogeneous and shown to be associated with functional outcomes. Our results have shed lights on future pathophysiological research and designs of clinical trials for PCS.
authors.affiliation: Department of Neurology, Taipei Veterans General Hospital Taipei, Taiwan ; National Yang Ming University Taipei, Taiwan.
authors.forename: Chih-Ping
authors.initials: CP
authors.lastname: Chung
authors.affiliation: Department of Neurology, Taipei Veterans General Hospital Taipei, Taiwan.
authors.forename: Chin-Sern
authors.initials: CS
authors.lastname: Yong
authors.affiliation: National Yang Ming University Taipei, Taiwan ; Department of Radiology, Taipei Veterans General Hospital Taipei, Taiwan.
authors.forename: Feng-Chi
authors.initials: FC
authors.lastname: Chang
authors.affiliation: Department of Neurology, Taipei Veterans General Hospital Taipei, Taiwan.
authors.forename: Wen-Yung
authors.initials: WY
authors.lastname: Sheng
authors.affiliation: Department of Neurology, Taipei Veterans General Hospital Taipei, Taiwan ; National Taipei University of Nursing and Health Sciences Taipei, Taiwan.
authors.forename: Hui-Chi
authors.initials: HC
authors.lastname: Huang
authors.affiliation: Department of Neurology, Taipei Veterans General Hospital Taipei, Taiwan ; National Taipei University of Nursing and Health Sciences Taipei, Taiwan.
authors.forename: Jui-Yao
authors.initials: JY
authors.lastname: Tsai
authors.affiliation: Department of Neurology, Tungs' Taichung Metro Harbor Hospital, School of Medicine, Chung Shan Medical University Taichung, Taiwan.
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Hsu
authors.affiliation: Department of Neurology, Taipei Veterans General Hospital Taipei, Taiwan ; National Yang Ming University Taipei, Taiwan.
authors.forename: Han-Hwa
authors.initials: HH
authors.lastname: Hu