title: Functional Polymorphisms in COX-2 Gene Are Correlated with the Risk of Oral Cancer.
abstract: BACKGROUND
  This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer.
  
  
  METHODS
  Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software.
  
  
  RESULTS
  We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated that +837 T > C (rs5275) polymorphism in COX-2 showed statistically significant differences in gene frequencies in case and control groups in allele model and dominant model. Similar results were obtained with COX-2 gene polymorphism 765 G > C (rs20417). On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers.
  
  
  CONCLUSIONS
  Based on our results, COX-2 gene polymorphisms, +837 T > C (rs5275) and -765G > C (rs20417), showed clear links with oral cancer susceptibility, and the 1195A > G (rs689466) polymorphism did not show such a correlation.
authors.affiliation: Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Li
authors.affiliation: The Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Hao
authors.affiliation: The Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: The Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Chun-Mei
authors.initials: CM
authors.lastname: Hu
authors.affiliation: Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Ma
authors.affiliation: Department of Oral Surgery, Shengjing Hospital of Youyi Medical University, Jiulong 999077, Hong Kong.
authors.forename: Zhi Ming
authors.initials: ZM
authors.lastname: Wang
authors.affiliation: Experimental Technology Center of Youyi Medical University, Jiulong 999077, Hong Kong.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Statistics, School of Public Health, Youyi Medical University, Jiulong 999077, Hong Kong.
authors.forename: Hong Bo
authors.initials: HB
authors.lastname: Liu
authors.affiliation: Department of Statistics, School of Public Health, Youyi Medical University, Jiulong 999077, Hong Kong.
authors.forename: Ming
authors.initials: M
authors.lastname: Ye
authors.affiliation: Department of Oral Surgery, Shengjing Hospital of Youyi Medical University, Jiulong 999077, Hong Kong.
authors.forename: Yu Fei
authors.initials: YF
authors.lastname: Zhang
authors.affiliation: Department of Oral Surgery, Shengjing Hospital of Youyi Medical University, Jiulong 999077, Hong Kong.
authors.forename: Dong Sheng
authors.initials: DS
authors.lastname: Yang
authors.affiliation: The Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun 130041, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Shi
mesh_terms: D016022:Case-Control Studies; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human