title: [Analysis and computational fluid dynamics simulation of hemodynamic influences caused by splenic vein thrombosis].
abstract: This paper aims to analyze the impact of splenic vein thrombosis (SVT) on the hemodynamic parameters in hepatic portal vein system. Based on computed tomography (CT) images of a patient with portal hypertension and commercial software MIMICS, the patient's portal venous system model was reconstructed. Color Doppler ultrasound method was used to measure the blood flow velocity in portal vein system and then the blood flow velocities were used as the inlet boundary conditions of simulation. By using the computational fluid dynamics (CFD) method, we simulated the changes of hemodynamic parameters in portal venous system with and without splenic vein thrombosis and analyzed the influence of physiological processes. The simulation results reproduced the blood flow process in portal venous system and the results showed that the splenic vein thrombosis caused serious impacts on hemodynamics. When blood flowed through the thrombosis, blood pressure reduced, flow velocity and wall shear stress increased. Flow resistance increased, blood flow velocity slowed down, the pressure gradient and wall shear stress distribution were more uniform in portal vein. The blood supply to liver decreased. Splenic vein thrombosis led to the possibility of forming new thrombosis in portal vein and surroundings.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.forename: Peiyun
authors.initials: P
authors.lastname: Gong
authors.forename: Xuesen
authors.initials: X
authors.lastname: Du
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D006975:Hypertension, Portal; D008103:Liver Cirrhosis; D011169:Portal Vein; D013162:Splenic Vein / Q000473:pathology*; D013927:Thrombosis / Q000473:pathology*; D014057:Tomography, X-Ray Computed