title: Prevalence of fatty liver disease and the economy in China: A systematic review.
abstract: OBJECTIVE
  To investigate the relationship between the economy and the adult prevalence of fatty liver disease (FLD) in mainland China.
  
  
  METHODS
  Literature searches on the PubMed and Chinese National Knowledge Infrastructure databases were performed to identify eligible studies published before July 2014. Records were limited to cross-sectional surveys or baseline surveys of longitudinal studies that reported the adult prevalence of FLD and recruited subjects from the general population or community. The gross domestic product (GDP) per capita was chosen to assess the economic status. Multiple linear regression and Loess regression were chosen to fit the data and calculate the 95%CIs. Fitting and overfitting of the models were considered in choosing the appropriate models.
  
  
  RESULTS
  There were 27 population-based surveys from 26 articles included in this study. The pooled mean prevalence of FLD in China was 16.73% (95%CI: 13.92%-19.53%). The prevalence of FLD was correlated with the GDP per capita and survey years in the country (adjusted R (2) = 0.8736, P GDP per capita = 0.00426, P years = 0.0000394), as well as in coastal areas (R (2) = 0.9196, P GDP per capita = 0.00241, P years = 0.00281). Furthermore, males [19.28% (95%CI: 15.68%-22.88%)] presented a higher prevalence than females [14.1% (95%CI: 11.42%-16.61%), P = 0.0071], especially in coastal areas [21.82 (95%CI: 17.94%-25.71%) vs 17.01% (95%CI: 14.30%-19.89%), P = 0.0157]. Finally, the prevalence was predicted to reach 20.21% in 2020, increasing at a rate of 0.594% per year.
  
  
  CONCLUSIONS
  This study reveals a correlation between the economy and the prevalence of FLD in mainland China.
authors.affiliation: Jin-Zhou Zhu, Yu-Ming Wang, Yi-Ning Dai, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Jin-Zhou
authors.initials: JZ
authors.lastname: Zhu
authors.affiliation: Jin-Zhou Zhu, Yu-Ming Wang, Yi-Ning Dai, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Qin-Yi
authors.initials: QY
authors.lastname: Zhou
authors.affiliation: Jin-Zhou Zhu, Yu-Ming Wang, Yi-Ning Dai, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Wang
authors.affiliation: Jin-Zhou Zhu, Yu-Ming Wang, Yi-Ning Dai, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Dai
authors.affiliation: Jin-Zhou Zhu, Yu-Ming Wang, Yi-Ning Dai, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Jin-Zhou Zhu, Yu-Ming Wang, Yi-Ning Dai, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: Chao-Hui
authors.initials: CH
authors.lastname: Yu
authors.affiliation: Jin-Zhou Zhu, Yu-Ming Wang, Yi-Ning Dai, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
authors.forename: You-Ming
authors.initials: YM
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D005260:Female; D059066:Gross Domestic Product; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000175:diagnosis / Q000191:economics* / Q000453:epidemiology*; D015995:Prevalence; D012111:Residence Characteristics; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors; D012959:Socioeconomic Factors; D055815:Young Adult
keywords: Economy; Epidemiology; Fatty liver disease; Gross domestic product per capita; Prevalence