title: Clinical correlates of enlarged cavum septum pellucidum in schizophrenia: A revisit through computed tomography.
abstract: Like prevalence of abnormal cavum septum pellucidum in patients of schizophrenia remains controversial, its role in clinical outcome, duration of illness and effect on treatment remains less understood as well. Our study examined clinical correlates of enlarged cavum septum pellucidum in schizophrenia. A total of 139 patients diagnosed with schizophrenia during the year 2012 and 2013 were taken for the study. We compared them in respect to the presence and absence of enlarged cavum septum pellucidum. We found 16 patients with enlarged cavum septum pellucidum and were compared with those without enlarged cavum septum pellucidum for socio-demographic and clinical variables. We also correlated these clinical variables with dimension of cavum septum pellucidum. We found statistically significant increased current age and duration of illness in patients with enlarged cavum septum pellucidum. The implications of these findings are discussed with possible confounding effect of current age on neuroimaging. No meaningful correlation was found. No difference in clinical variables was found. Retrospective design and use of computed tomography were limitation of our study.
authors.affiliation: Department of Psychiatry, Central Institute of Psychiatry, Ranchi 834006, India. Electronic address: navnsrivastava02@gmail.com.
authors.forename: Naveen Kumar
authors.initials: NK
authors.lastname: Srivastava
authors.affiliation: Department of Psychiatry, ICARE Institute of Medical Sciences & Research, Haldia 721645, India. Electronic address: souravpsy@gmail.com.
authors.forename: Sourav
authors.initials: S
authors.lastname: Khanra
authors.affiliation: Center for Neuroimaging and Radio diagnosis, Central Institute of Psychiatry, Ranchi 834006, India. Electronic address: vchail@gmail.com.
authors.forename: Vivek
authors.initials: V
authors.lastname: Chail
authors.affiliation: Department of Psychiatry, Central Institute of Psychiatry, Ranchi 834006, India. Electronic address: jmou@rediffmail.com.
authors.forename: Christoday R J
authors.initials: CR
authors.lastname: Khess
mesh_terms: D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D009929:Organ Size; D012189:Retrospective Studies; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000473:pathology*; D012688:Septum Pellucidum / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed
keywords: Cavum septum pellucidum; Clinical; Computed tomography; Correlates; Enlarged; Schizophrenia