title: Possibility of breast cancer prevention: use of soy isoflavones and fermented soy beverage produced using probiotics.
abstract: The various beneficial effects of soybeans, which are rich in phytochemicals, have received much attention because of increasing health awareness. Soy milk that has been fermented using lactic acid bacteria has been used to prepare cheese-like products, tofu (bean-curd), and yogurt-type products. However, the distinct odor of soybeans has limited the acceptance of such foods, particularly in Western countries. In Japan, while tofu and soy milk have long been habitually consumed, the development of novel, palatable food products has not been easy. The unpleasant odor of soy milk and the absorption efficiency for isoflavones can be improved using a recently developed fermented soy milk beverage. Cancer has been the leading cause of death, and breast cancer is the most common malignancy among women. The most common type of breast cancer is estrogen-dependent, and the anti-estrogenic effects of isoflavones are known. The present review focuses on the characteristics of soy milk fermented using probiotics, an epidemiological study examining the incidence of breast cancer and soy isoflavone consumption, and a non-clinical study examining breast cancer prevention using fermented soy milk beverage.
authors.affiliation: Pharmaceutical Research Laboratory, Yakult Central Institute, Tokyo 186-8650, Japan. akimitsu-takagi@yakult.co.jp.
authors.forename: Akimitsu
authors.initials: A
authors.lastname: Takagi
authors.affiliation: Food Research Laboratory, Yakult Central Institute, Tokyo 186-8650, Japan. mitsuyoshi-kano@yakult.co.jp.
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Kano
authors.affiliation: Food Research Laboratory, Yakult Central Institute, Tokyo 186-8650, Japan. chiaki-kaga@yakult.co.jp.
authors.forename: Chiaki
authors.initials: C
authors.lastname: Kaga
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005285:Fermentation; D006801:Humans; D007529:Isoflavones / Q000627:therapeutic use*; D019936:Probiotics / Q000627:therapeutic use*; D041942:Soy Milk / Q000737:chemistry*; D013025:Glycine max / Q000737:chemistry*
chemical_list: D007529:Isoflavones
keywords: L. casei Shirota; breast cancer; fermented soy milk; isoflavone; probiotics