title: Impact of transcatheter aortic valve implantation on the left ventricular mass.
abstract: BACKGROUND
  Aortic stenosis (AS) induces pressure overload of the left ventricle (LV) and results in left ventricular hypertrophy. The remodeling of the LV in patients with AS is a com-plex process including structural and functional disturbances. After aortic valve replacement, reverse remodeling of LV begins. The aim of this study was to evaluate the impact of transcatheter aortic valve ımplantation (TAVI) on LV mass (LVM) in early and mid-term follow-ups after the procedure.
  
  
  RESULTS
  We enrolled consecutive 75 patients who underwent successful TAVI. Transthoracic echocardiography was performed prior to TAVI and at hospital discharge, in the 1st month and 6th month of the follow-ups. The mean LV ejection fraction improved significantly after TAVI (54.2 ± 15.0% to 57.3 ± 11.7%, p < 0.001). There were no significant changes between the baseline and discharge mean LVM and LVM index values (LVMI; p = 0.1). However, LVMI decreased significantly in the 1st month of follow-up compared to baseline (123.3 ± 20.3 to 127.9 ± 21.3 g/m², respectively, p < 0.001). Also, significant regression of LVM was observed at the 1st month of follow-up compared to baseline (228.3 ± 33.5 g vs. 236.5 ± 34.2 g, respectively, p < 0.001). Furthermore, the significant regression in both of LVM and LVMI continued at 1st and 6th months of the follow-ups (p < 0.001).
  
  
  CONCLUSIONS
  A significant regression of LVM was observed after TAVI. These changes may have prognostic value in patients with severe AS.
authors.forename: Hacı Ahmet
authors.initials: HA
authors.lastname: Kasapkara
authors.affiliation: Yıldırım Beyazıt University, Faculty of Medicine, Department of Cardiology. huseyinayhan44@yahoo.com.
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ayhan
authors.forename: Cenk
authors.initials: C
authors.lastname: Sarı
authors.forename: Abdullah Nabi
authors.initials: AN
authors.lastname: Aslan
authors.forename: Hakan
authors.initials: H
authors.lastname: Süygün
authors.forename: Serdal
authors.initials: S
authors.lastname: Baştuğ
authors.forename: Tahir
authors.initials: T
authors.lastname: Durmaz
authors.forename: Telat
authors.initials: T
authors.lastname: Keleş
authors.forename: Engin
authors.initials: E
authors.lastname: Bozkurt
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D017548:Echocardiography, Transesophageal; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011379:Prognosis; D020127:Recovery of Function / Q000502:physiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology*; D065467:Transcatheter Aortic Valve Replacement; D016277:Ventricular Function, Left / Q000502:physiology*
keywords: TAVI; aortic valve stenosis; left ventricular mass