title: An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling.
abstract: Interleukin-17A (IL-17A) and its receptor (IL-17RA) are prototype members of IL-17 ligand/receptor family firstly identified in CD4+ T cells, which comprises six ligands (IL-17A to IL- 17F) and five receptors (IL-17RA to IL-17RE). IL-17A is predominantly secreted by T helper 17 (Th17) cells, and plays important roles in the development of autoimmune and inflammatory diseases. IL-17RA is widely expressed, and forms a complex with IL-17RC. Binding of IL-17A to this receptor complex triggers the activation of several intracellular signaling pathways. In this review, we aimed to summarize literature data about molecular features of IL-17A and IL-17RA from gene to mature protein. We are also providing insight into regulatory mechanisms, protein structural conformation, including ligand-receptor interaction, and an overview of signaling pathways. Our aim was to compile the data on molecular characteristics of IL-17A and IL-17RA which may help in the understanding of their functions in health and disease.
authors.forename: Jelena
authors.initials: J
authors.lastname: Krstic
authors.forename: Hristina
authors.initials: H
authors.lastname: Obradovic
authors.forename: Tamara
authors.initials: T
authors.lastname: Kukolj
authors.forename: Slavko
authors.initials: S
authors.lastname: Mojsilovic
authors.forename: Ivana
authors.initials: I
authors.lastname: Okic-Dordevic
authors.forename: Diana
authors.initials: D
authors.lastname: Bugarski
authors.affiliation: Laboratory for Experimental Hematology and Stem cells. Institte for Medical Research, University of Belgrade, Dr Subotica 4, 11129 Belgrade, Serbia. jfsantibanez@imi.bg.ac.rs.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Santibanez
mesh_terms: D000818:Animals; D006801:Humans; D020381:Interleukin-17 / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D053722:Receptors, Interleukin-17 / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17