title: Infiltrative lymphomatous optic neuropathy in non-Hodgkin lymphoma.
abstract: We report a 67-year-old man with non-Hodgkin lymphoma who presented with fluctuating visual loss which responded partially to steroid treatment. Multiple lumbar punctures did not show lymphoblastic cells and multiple MRI did not show any central nervous system disease except for isolated optic nerve enhancement. A fundus examination revealed combined arterial and venous occlusion and optic disc swelling. Due to conflicts between the examinations and investigations, there was a reluctance to initiate radiotherapy until progressive changes involving both eyes occurred. The man died 8 months after he was diagnosed with lymphoma. A post mortem optic nerve biopsy showed lymphomatous infiltration, confirming that the initial suspicion based on the clinical findings was correct.
authors.affiliation: Eye Department, Christchurch Public Hospital, 19 St Asaph Street, Christchurch 8011, New Zealand. Electronic address: dick23son@hotmail.com.
authors.forename: Dickson
authors.initials: D
authors.lastname: Wong
authors.affiliation: University of Auckland, Auckland, New Zealand.
authors.forename: Helen
authors.initials: H
authors.lastname: Danesh-Meyer
authors.affiliation: Eye Department, Christchurch Public Hospital, 19 St Asaph Street, Christchurch 8011, New Zealand.
authors.forename: Jo-Anne
authors.initials: JA
authors.lastname: Pon
mesh_terms: D000368:Aged; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009901:Optic Nerve Diseases / Q000209:etiology*
keywords: Lymphomatous infiltration; Non-Hodgkin lymphoma; Optic neuropathy