title: Differences in early speech patterns between Parkinson variant of multiple system atrophy and Parkinson's disease.
abstract: In Parkinson variant of multiple system atrophy (MSA-P), patterns of early speech impairment and their distinguishing features from Parkinson's disease (PD) require further exploration. Here, we compared speech data among patients with early-stage MSA-P, PD, and healthy subjects using quantitative acoustic and perceptual analyses. Variables were analyzed for men and women in view of gender-specific features of speech. Acoustic analysis revealed that male patients with MSA-P exhibited more profound speech abnormalities than those with PD, regarding increased voice pitch, prolonged pause time, and reduced speech rate. This might be due to widespread pathology of MSA-P in nigrostriatal or extra-striatal structures related to speech production. Although several perceptual measures were mildly impaired in MSA-P and PD patients, none of these parameters showed a significant difference between patient groups. Detailed speech analysis using acoustic measures may help distinguish between MSA-P and PD early in the disease process.
authors.affiliation: Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 81 Irwon-Ro, Gangnam-gu, Seoul 135-710, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, 81 Irwon-Ro, Gangnam-gu, Seoul 135-710, Republic of Korea.
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Huh
authors.affiliation: Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 81 Irwon-Ro, Gangnam-gu, Seoul 135-710, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, 81 Irwon-Ro, Gangnam-gu, Seoul 135-710, Republic of Korea.
authors.forename: Jongkyu
authors.initials: J
authors.lastname: Park
authors.affiliation: Neuroscience Center, Samsung Medical Center, Seoul, 81 Irwon-Ro, Gangnam-gu, Seoul 135-710, Republic of Korea.
authors.forename: Mee Kyung
authors.initials: MK
authors.lastname: Suh
authors.affiliation: Department of Rehabilitation Medicine, Gangnam Severance Hospital, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Sang Eun
authors.initials: SE
authors.lastname: Lee
authors.affiliation: Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 81 Irwon-Ro, Gangnam-gu, Seoul 135-710, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, 81 Irwon-Ro, Gangnam-gu, Seoul 135-710, Republic of Korea.
authors.forename: Jumin
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Neurology, G SAM Hospital, 613-8 Anyang-dong, Manan-gu, Anyang 430-733, Republic of Korea.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Jeong
authors.affiliation: Department of Neurology, College of Medicine, Hanyang University, 222-1 Wangsimni-ro, Seongdong-gu, Seoul 133-792, Republic of Korea.
authors.forename: Hee-Tae
authors.initials: HT
authors.lastname: Kim
authors.affiliation: Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 81 Irwon-Ro, Gangnam-gu, Seoul 135-710, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, 81 Irwon-Ro, Gangnam-gu, Seoul 135-710, Republic of Korea. Electronic address: jinwhan.cho@samsung.com.
authors.forename: Jin Whan
authors.initials: JW
authors.lastname: Cho
mesh_terms: D000162:Acoustics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003342:Corpus Striatum / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology*; D013060:Speech / Q000502:physiology; D013064:Speech Disorders / Q000503:physiopathology*
keywords: Acoustic analysis; Multiple system atrophy; Parkinson’s disease; Perceptual analysis; Speech