title: A tetraphenylimidazole-based fluorescent probe for the detection of hydrogen sulfide and its application in living cells.
abstract: A novel probe based on the fluorescence off-on strategy was prepared to optically detect hydrogen sulfide (H2S) via an excited state intramolecular proton transfer (ESIPT) mechanism. The probe shows high sensitivity and excellent selectivity to H2S. It also displays a large Stokes shift (∼140 nm) and a remarkable quantum yield enhancement (Ф=0.412) after interaction with H2S. Moreover, the cellular imaging experiment demonstrated that it has potential utility for H2S sensing in biological sciences.
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Biao
authors.initials: B
authors.lastname: Gu
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Naxiu
authors.initials: N
authors.lastname: Mi
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Youyu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Pen
authors.initials: P
authors.lastname: Yin
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China. Electronic address: haitao-li@hunnu.edu.cn.
authors.forename: Haitao
authors.initials: H
authors.lastname: Li
authors.affiliation: Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, PR China.
authors.forename: Shouzhuo
authors.initials: S
authors.lastname: Yao
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis*; D007093:Imidazoles / Q000737:chemistry*; D008856:Microscopy, Fluorescence; D061848:Optical Imaging; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D007093:Imidazoles; D006862:Hydrogen Sulfide
keywords: Cellular imaging; ESIPT; Hydrogen sulfide; Probe