title: Validating the anticancer potential of carbon nanotube-based therapeutics through cell line testing.
abstract: Recent years have witnessed the booming development of carbon nanotubes (CNTs) and their composites in biological and medicine. By virtue of their unique physicochemical properties, CNTs have emerged as potential tools in biomedical applications as a result of their development as safe, effective nanomedicines. Diverse cell lines have been shown to be best-fit experimental models for evaluating the pharmacokinetic parameters, cell viability, and cytotoxicity of CNTS, as well as their drug efficacy ex vivo, which can then be correlated with their in vivo performance. The biological activities and cytotoxic effects of CNTs are dependent on their surface chemistry, and how they are purified and functionalized. Here, we focus on aspects of CNTs including their functionalization, and their biomedical potential and limitations, emphasizing the toxicological aspects of functionalized CNTs using various cell lines. The outlook for CNT-based nanomedicine, particularly in cancer treatment, is fascinating and encouraging. In vitro cell line data can assist the selection of specific cancer cell lines for the evaluation of anticancer bioactive-loaded CNTs as a novel drug delivery tool in the diagnosis and treatment of cancer.
authors.affiliation: Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Central University, Sagar, MP 470 003, India; Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA. Electronic address: prashantdops@gmail.com.
authors.forename: Prashant
authors.initials: P
authors.lastname: Kesharwani
authors.affiliation: Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Central University, Sagar, MP 470 003, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Mishra
authors.affiliation: Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Central University, Sagar, MP 470 003, India.
authors.forename: Narendra Kumar
authors.initials: NK
authors.lastname: Jain
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D006801:Humans; D050997:Nanomedicine; D037742:Nanotubes, Carbon; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D037742:Nanotubes, Carbon