title: Multifunctional layered gadolinium hydroxide nanoplates for ultrahigh field magnetic resonance imaging, computed tomography and fluorescence bioimaging.
abstract: The commonly used clinical magnetic resonance imaging (MRI) contrast agents are generally suitable for MR systems with a magnetic field less than 3.0 T. However, these agents show low contrast efficacy for MR systems with ultrahigh fields ≥ 7.0 T, which is the direction that next-generation MRI scanners are heading. A new contrast agent consisting of layered gadolinium hydroxide nanoplates doped with Ce and Tb (LGdH:Ce,Tb NPs) is presented herein. This material exhibits excellent negative (T2) contrast agent efficacy for 7.0 T MRI with a high r2/r1 ratio of 48.80, whereas it exhibits a lower r2/r1 ratio of 30.60 for 3.0 T MRI. Its performance as a T2 contrast agent in ultrahigh field MRI of subcutaneous liver tumor-bearing nude mice is investigated, demonstrating its ability to be used as a negative target T2 contrast agent to distinguish hepatic carcinoma from healthy tissues. Furthermore, the multifunctionality of the LGdH:Ce,Tb NPs as a contrast agent in X-ray computed tomography (CT) and fluorescence bioimaging is also presented, suggesting the possibility of integrating these imaging technologies for in-depth exploration of bioimaging.
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yu
authors.forename: Daquan
authors.initials: D
authors.lastname: Zhang
authors.forename: Tianying
authors.initials: T
authors.lastname: Sun
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Sun
authors.forename: Su
authors.initials: S
authors.lastname: Lui
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Huang
authors.forename: Feng
authors.initials: F
authors.lastname: Bi
authors.forename: Huaiyu
authors.initials: H
authors.lastname: Wang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhu
authors.forename: Qiyong
authors.initials: Q
authors.lastname: Gong
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis; D005682:Gadolinium / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D008856:Microscopy, Fluorescence / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D005682:Gadolinium