title: [A Case of Paradoxical Reaction Development during Antituberculosis Therapy].
abstract: Paradoxical reaction during antituberculosis therapy is defined as aggravation of preexisting tuberculous lesions or the development of new lesions. A 24-year-old female college student diagnosed with abdominal and pulmonary tuberculosis presented with fever and abdominal pain after having been treated with antituberculosis agents for 4 months. Tuberculous mesenteric lymphadenitis was suspected on abdominal CT scan and enlarged necrotic abscess was also present. These findings were considered to be due to paradoxical reaction rather than treatment failure during antituberculosis treatment. Although laparoscopic bowel adhesiolysis and abscess drainage were performed, high fever and severe abdominal pain did not improve. However, the patient eventually made a completely recovery after corticosteroid therapy combined with antituberculosis agents. Herein, we report a case of paradoxical reaction which developed in a patient with abdominal and pulmonary tuberculosis during antituberculosis therapy.
authors.affiliation: Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Young Bum
authors.initials: YB
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Min Su
authors.initials: MS
authors.lastname: Chu
authors.affiliation: Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Han Seung
authors.initials: HS
authors.lastname: Ryu
authors.affiliation: Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Suck Chei
authors.initials: SC
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea.
authors.forename: Geom Seog
authors.initials: GS
authors.lastname: Seo
mesh_terms: D000038:Abscess; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004322:Drainage; D005260:Female; D006801:Humans; D008640:Mesenteric Lymphadenitis / Q000209:etiology; D014057:Tomography, X-Ray Computed; D014376:Tuberculosis / Q000188:drug therapy* / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000473:pathology; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D000995:Antitubercular Agents
keywords: Corticosteroid; Paradoxical reaction; Peritonitis, tuberculous; Tuberculosis, pulmonary