title: Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.
abstract: To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.
authors.forename: J W M
authors.initials: JW
authors.lastname: van der Linden
authors.forename: M C
authors.initials: MC
authors.lastname: Arendrup
authors.forename: A
authors.initials: A
authors.lastname: Warris
authors.forename: K
authors.initials: K
authors.lastname: Lagrou
authors.forename: H
authors.initials: H
authors.lastname: Pelloux
authors.forename: P M
authors.initials: PM
authors.lastname: Hauser
authors.forename: E
authors.initials: E
authors.lastname: Chryssanthou
authors.forename: E
authors.initials: E
authors.lastname: Mellado
authors.forename: S E
authors.initials: SE
authors.lastname: Kidd
authors.forename: A M
authors.initials: AM
authors.lastname: Tortorano
authors.forename: E
authors.initials: E
authors.lastname: Dannaoui
authors.forename: P
authors.initials: P
authors.lastname: Gaustad
authors.forename: J W
authors.initials: JW
authors.lastname: Baddley
authors.forename: A
authors.initials: A
authors.lastname: Uekötter
authors.forename: C
authors.initials: C
authors.lastname: Lass-Flörl
authors.forename: N
authors.initials: N
authors.lastname: Klimko
authors.forename: C B
authors.initials: CB
authors.lastname: Moore
authors.forename: D W
authors.initials: DW
authors.lastname: Denning
authors.forename: A C
authors.initials: AC
authors.lastname: Pasqualotto
authors.forename: C
authors.initials: C
authors.lastname: Kibbler
authors.forename: S
authors.initials: S
authors.lastname: Arikan-Akdagli
authors.forename: D
authors.initials: D
authors.lastname: Andes
authors.forename: J
authors.initials: J
authors.lastname: Meletiadis
authors.forename: L
authors.initials: L
authors.lastname: Naumiuk
authors.forename: M
authors.initials: M
authors.lastname: Nucci
authors.forename: W J G
authors.initials: WJ
authors.lastname: Melchers
authors.forename: P E
authors.initials: PE
authors.lastname: Verweij
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000453:epidemiology* / Q000382:microbiology*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000235:genetics; D001393:Azoles / Q000494:pharmacology*; D025141:Drug Resistance, Fungal; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D011159:Population Surveillance; D015995:Prevalence; D011446:Prospective Studies
chemical_list: D000935:Antifungal Agents; D001393:Azoles
keywords: Aspergillus; antimicrobial resistance; aspergillosis; azole resistance; fungi; international; prevalence; surveillance