title: [Cell signaling pathways interaction in cellular proliferation: Potential target for therapeutic interventionism].
abstract: Nowadays, cellular physiology is best understood by analysing their interacting molecular components. Proteins are the major components of the cells. Different proteins are organised in the form of functional clusters, pathways or networks. These molecules are ordered in clusters of receptor molecules of extracellular signals, transducers, sensors and biological response effectors. The identification of these intracellular signaling pathways in different cellular types has required a long journey of experimental work. More than 300 intracellular signaling pathways have been identified in human cells. They participate in cell homeostasis processes for structural and functional maintenance. Some of them participate simultaneously or in a nearly-consecutive progression to generate a cellular phenotypic change. In this review, an analysis is performed on the main intracellular signaling pathways that take part in the cellular proliferation process, and the potential use of some components of these pathways as target for therapeutic interventionism are also underlined.
authors.affiliation: Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Unidad Xochimilco de la Ciudad de México, Ciudad de México, México. Electronic address: vvaldespinog@yahoo.com.mx.
authors.forename: Víctor Manuel
authors.initials: VM
authors.lastname: Valdespino-Gómez
authors.affiliation: Instituto de Ecología, Universidad Nacional Autónoma de México, Ciudad de México, México.
authors.forename: Patricia Margarita
authors.initials: PM
authors.lastname: Valdespino-Castillo
authors.affiliation: Unidad Médica de Atención Ambulatoria, Instituto Mexicano del Seguro Social, Campeche, Campeche, México.
authors.forename: Víctor Edmundo
authors.initials: VE
authors.lastname: Valdespino-Castillo
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects / Q000502:physiology*; D004358:Drug Therapy; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
keywords: Cell proliferation process; Intracellular signaling pathways; Proceso de proliferación celular; Vías de señalización intracelulares