title: Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population.
abstract: Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population.
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland .
authors.forename: Mateusz
authors.initials: M
authors.lastname: Kurzawski
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland .
authors.forename: Anna
authors.initials: A
authors.lastname: Wajda
authors.affiliation: Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland .
authors.forename: Damian
authors.initials: D
authors.lastname: Malinowski
authors.affiliation: Department of Reproductive Medicine and Gynecology, Pomeranian Medical University, Szczecin, Poland .
authors.forename: Anna
authors.initials: A
authors.lastname: Kazienko
authors.affiliation: Department of Reproductive Medicine and Gynecology, Pomeranian Medical University, Szczecin, Poland .
authors.forename: Rafal
authors.initials: R
authors.lastname: Kurzawa
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland .
authors.forename: Marek
authors.initials: M
authors.lastname: Drozdzik
keywords: MTHFR; MTR; MTRR; infertility; polymorphism