title: Therapeutic Challenges in Diabetes Prevention: We Have Not Found the "Exercise Pill".
abstract: Type 2 diabetes has become an enormous public health burden, making diabetes prevention a pressing issue. While lifestyle modification is the most effective preventive strategy, it is resource-intensive and not universally sustainable. We review the evidence on pharmacological options for diabetes prevention, in search of a medication that is efficacious, easy to adhere to, well tolerated, and cost-effective. With the exception of metformin, most other drugs have either limited efficacy or costly side effects.
authors.affiliation: Pediatric Endocrine Unit, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.|Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.|Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.|Program in Medical and Population Genetics, Broad Institute of Harvard & Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: S
authors.initials: S
authors.lastname: Srinivasan
authors.affiliation: Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.|Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.|Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.|Program in Medical and Population Genetics, Broad Institute of Harvard & Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Florez
mesh_terms: D000818:Animals; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D004032:Diet / Q000009:adverse effects; D015444:Exercise; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008687:Metformin / Q000627:therapeutic use; D011322:Primary Prevention / Q000379:methods*; D065840:Protective Factors; D018570:Risk Assessment; D012307:Risk Factors; D040242:Risk Reduction Behavior; D016896:Treatment Outcome
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin