title: HIV integrase inhibitors: a new era in the treatment of HIV.
abstract: BACKGROUND
  Integrase inhibitors (INIs) are the latest class of antiretroviral drugs approved for the treatment of HIV infection and are becoming 'standard' drugs in the treatment of both naïve as well as heavily pretreated individuals with HIV.
  
  
  METHODS
  Data on efficacy, safety, tolerability, pharmacokinetics, drug-drug interactions and resistance are reviewed from the pivotal Phase III clinical trials published in PubMed high-impact medical journals or presented at international meetings.
  
  
  CONCLUSIONS
  Due to their outstanding data of efficacy, tolerability, safety--shared by all three drugs (raltegravir, elvitegravir, dolutegravir) currently belonging to this new family of antiretrovirals--INIs have become part of the recommended initial antiretroviral therapy options. Some differences in dosing, drug-drug interactions and robustness/genetic barrier among the three drugs will provide the physician the characteristics to make the best choice.
authors.affiliation: Hospital Clinic Barcelona , C.Villaroele 08037 , Barcelona jlblanco@clinic.ub.es.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Blanco
authors.forename: Gary
authors.initials: G
authors.lastname: Whitlock
authors.forename: Ana
authors.initials: A
authors.lastname: Milinkovic
authors.forename: Graeme
authors.initials: G
authors.lastname: Moyle
mesh_terms: D002986:Clinical Trials as Topic; D015658:HIV Infections / Q000188:drug therapy*; D019428:HIV Integrase Inhibitors / Q000627:therapeutic use*; D006575:Heterocyclic Compounds, 3-Ring / Q000627:therapeutic use; D006801:Humans; D010078:Oxazines; D010879:Piperazines; D011728:Pyridones; D011760:Pyrrolidinones / Q000627:therapeutic use; D015363:Quinolones / Q000627:therapeutic use; D000068898:Raltegravir Potassium; D000099226:Dolutegravir
chemical_list: D019428:HIV Integrase Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D010078:Oxazines; D010879:Piperazines; D011728:Pyridones; D011760:Pyrrolidinones; D015363:Quinolones; D000068898:Raltegravir Potassium; D000099226:Dolutegravir; C509700:elvitegravir
keywords: HIV; dolutegravir; elvitegravir; integrase inhibitors; raltegravir