title: [Cytokines profile and metabolic activity of neutrophils of peripheral blood when progressing neoplasma].
abstract: The neutrophil is considered as the peculiar monocelled sekretorny gland realizing the effector potential including by secretion of soluble products - cytokines and for today. Influence of a tumor on functional activity of neutrophils depends on type, localization and a stage of its development. In our research dynamics of metabolic and of neutrophils of peripheral blood, the contents in a lysate and serums of blood of cytokines of IL-1β, 1Ra, 2, 6, 10, 18, TNF-α, IFN-γ and is studied when progressing a cervical cancer. Cytokines and metabolism indicators - activity of, determined by an immunofermental method, level of cationic proteins, a share of active cages in the spontaneous NST-test were cytochemical. It is shown that when progressing cervical cancer against increase in total of neutrophils significant decrease in their, aerobic and anaerobic bacterial action, decrease in the IL-1β and IL-1 Ra level, and also IFN-γ takes place at TNF-α increase, increase of production of matrix metalloproteinas-2 on Ib-IIa of a stage of a disease that allows to assume emergence at this stage of cervical cancer of pro-tumoral effect of neutrophils.
authors.forename: T V
authors.initials: TV
authors.lastname: Abakumova
authors.forename: I I
authors.initials: II
authors.lastname: Antoneeva
authors.forename: T P
authors.initials: TP
authors.lastname: Gening
authors.forename: S O
authors.initials: SO
authors.lastname: Gening
authors.forename: D R
authors.initials: DR
authors.lastname: Dolgova
authors.forename: A V
authors.initials: AV
authors.lastname: Fomina
mesh_terms: D001770:Blood Bactericidal Activity; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D020778:Matrix Metalloproteinase 2 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D009367:Neoplasm Staging; D009504:Neutrophils / Q000378:metabolism* / Q000473:pathology; D010587:Phagocytosis; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000276:immunology / Q000473:pathology
chemical_list: D016207:Cytokines; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9