title: Effect of High Fat Diets on Body Mass, Oleylethanolamide Plasma Levels and Oxytocin Expression in Growing Rats.
abstract: Obesity prevalence in developed countries has promoted the need to identify the mechanisms involved in control of feeding and energy balance. We have tested the hypothesis that different fats present in diet composition may contribute in body weight gain and body indexes by regulation of oxytocin gene (oxt) expression in hypothalamus and Oleylethanolamide (OEA) levels in plasma. Sprague-Dawley rats were fed two high fat diets, based on corn (HCO) and extra virgin olive oil (HOO) and results were compared to a low fat diet (LF). LC-MS/MS analysis showed an increasing trend of OEA plasma levels in HOO group, although no significant differences were found. However, body weight gain of LF and HOO were similar and significantly lower than HCO. HCO rats also had higher Lee index than HOO. Rats fed HOO diet showed higher levels of hypothalamic oxt mRNA expression, which could indicate that oxytocin may be modulated by dietary lipids.
authors.affiliation: Dept. of Cell Biology, Physiology and Immunology, Physiology Unit, Medicine School, Univ. Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Sospedra
authors.affiliation: Dept. of Cell Biology, Physiology and Immunology, Physiology Unit, Medicine School, Univ. Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Moral
authors.affiliation: Dept. of Cell Biology, Physiology and Immunology, Physiology Unit, Medicine School, Univ. Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Escrich
authors.affiliation: Dept. of Cell Biology, Physiology and Immunology, Physiology Unit, Medicine School, Univ. Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Solanas
authors.affiliation: Dept. of Cell Biology, Physiology and Immunology, Physiology Unit, Medicine School, Univ. Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: Vela
authors.affiliation: Dept. of Cell Biology, Physiology and Immunology, Physiology Unit, Medicine School, Univ. Autònoma de Barcelona, Barcelona, Spain.
authors.forename: Eduard
authors.initials: E
authors.lastname: Escrich
mesh_terms: D000818:Animals; D015992:Body Mass Index; D001835:Body Weight; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D003314:Corn Oil; D018752:Diet, Fat-Restricted; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000378:metabolism; D008297:Male; D009765:Obesity; D009829:Oleic Acids / Q000097:blood*; D000069463:Olive Oil / Q000737:chemistry; D010121:Oxytocin / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D053719:Tandem Mass Spectrometry; D015430:Weight Gain
chemical_list: D004041:Dietary Fats; D009829:Oleic Acids; C440229:Oleylethanolamide; D000069463:Olive Oil; D012333:RNA, Messenger; D010121:Oxytocin; D003314:Corn Oil
keywords: Lee Index; body mass index; oleylethanolamide; olive oil; oxytocin