title: C1q nephropathy in a patient with Gitelman syndrome.
abstract: Bartter syndrome can manifest in three different forms and is rarely concomitant with glomerular nephropathies. However, this association is more frequently observed in children. We report the case of a 50-year-old woman with Gitelman syndrome for the past 30 years who also had a nephrotic syndrome of recent appearance. Her renal biopsy revealed hyperplasia of the juxtaglomerular apparatus and mesangial deposits of C1q, with no clinical or serological evidence of systemic erythematous lupus. We have not found any reports of instances of association of Gitelman syndrome and nephrotic syndrome arising from C1q nephropathy in adult patients. Our case suggests the possible existence of an association between hypokalaemic tubular nephropathies and glomerular nephropathies that may cause nephrotic syndrome.
authors.affiliation: Service of Nephrology, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Consolación
authors.initials: C
authors.lastname: Rosado Rubio
authors.affiliation: Service of Nephrology, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Fraile Gómez
authors.affiliation: Service of Pathology, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: María Asunción
authors.initials: MA
authors.lastname: Gómez Muñoz
authors.affiliation: Service of Nephrology, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Garcia-Cosmes
authors.affiliation: Service of Nephrology, University Hospital of Salamanca, Salamanca, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Lerma Márquez
keywords: Bartter syndrome; C1q nephropathy; Gitelman syndrome; nephrotic syndrome