title: The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases.
abstract: Peptidyl prolyl isomerases (PPIases) are proteins belonging to the immunophilin family and are characterised by their cis-trans isomerization activity at the X-Pro peptide bond, in addition to their tetratricopeptide repeat (TPR) domain, important for interaction with the molecular chaperone, Hsp90. Due to this unique structure these proteins are able to facilitate protein-protein interactions which can impact significantly on a range of cellular processes such as cell signalling, differentiation, cell cycle progression, metabolic activity and apoptosis. Malfunction and/or dysregulation of most members of this class of proteins promotes cellular damage and tissue/organ failure, predisposing to ageing and age-related diseases. Many individual genes within the PPIase family are associated with several age-related diseases including cardiovascular diseases (CVDs), atherosclerosis, type II diabetes mellitus (T2D), chronic kidney disease (CDK), neurodegeneration, cancer and age-related macular degeneration (AMD), in addition to the ageing process itself. This review will focus on the different roles of PPIases, and their therapeutic/ biomarker potential in these age-related vascular diseases.
authors.forename: Lana
authors.initials: L
authors.lastname: McClements
authors.forename: Stephanie
authors.initials: S
authors.lastname: Annett
authors.forename: Anita
authors.initials: A
authors.lastname: Yakkundi
authors.affiliation: School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, UK, BT9 7BL. t.robson@qub.ac.uk.
authors.forename: Tracy
authors.initials: T
authors.lastname: Robson
mesh_terms: D000375:Aging; D000818:Animals; D002318:Cardiovascular Diseases / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008268:Macular Degeneration / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D019696:Peptidylprolyl Isomerase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000201:enzymology / Q000378:metabolism / Q000473:pathology
chemical_list: D019696:Peptidylprolyl Isomerase