title: Association of IL-17 polymorphisms with gastric cancer risk in Asian populations.
abstract: OBJECTIVE
  To investigate associations between the IL-17 rs2275913 G>A and rs763780 T>C polymorphisms and susceptibility to gastric cancer in Asian populations.
  
  
  METHODS
  We reviewed studies published up to 2014 on IL-17 polymorphisms with gastric cancer susceptibility systematically. Relevant articles were identified in the MEDLINE, Science Citation Index, Cochrane Library, PubMed, EMBASE, CINAHL and Current Contents Index databases. We used version 12.0 STATA statistical software to evaluate the statistical data. Two reviewers abstracted the data independently. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated.
  
  
  RESULTS
  Seven independent, case-control studies were chosen for the meta-analysis, which included 3210 gastric cancer patients and 3889 healthy controls. The overall estimation showed a positive association between the IL-17 rs2275913 G>A polymorphism and the occurrence of gastric cancer for five genetic models (all P < 0.05) and similar results were observed for the IL-17 rs763780 T>C variation with four genetic models (all P < 0.05), but not for the dominant model (P > 0.05). Subgroup analysis by country revealed that the rs2275913 G>A and rs763780 T>C polymorphisms may be the main risk factor for gastric cancer in Chinese and Japanese populations.
  
  
  CONCLUSIONS
  The IL-17 gene may be significantly correlated with gastric cancer risk in Asian populations, especially those carrying the rs2275913 G>A and rs763780 T>C polymorphisms.
authors.affiliation: Zi-Wen Long, Hong-Mei Yu, Ya-Nong Wang, Dan Liu, Yan-Zhi Chen, Yu-Xia Zhao, Department of Gastric Cancer and Soft-Tissue Sacomas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Zi-Wen
authors.initials: ZW
authors.lastname: Long
authors.affiliation: Zi-Wen Long, Hong-Mei Yu, Ya-Nong Wang, Dan Liu, Yan-Zhi Chen, Yu-Xia Zhao, Department of Gastric Cancer and Soft-Tissue Sacomas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Yu
authors.affiliation: Zi-Wen Long, Hong-Mei Yu, Ya-Nong Wang, Dan Liu, Yan-Zhi Chen, Yu-Xia Zhao, Department of Gastric Cancer and Soft-Tissue Sacomas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Ya-Nong
authors.initials: YN
authors.lastname: Wang
authors.affiliation: Zi-Wen Long, Hong-Mei Yu, Ya-Nong Wang, Dan Liu, Yan-Zhi Chen, Yu-Xia Zhao, Department of Gastric Cancer and Soft-Tissue Sacomas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.affiliation: Zi-Wen Long, Hong-Mei Yu, Ya-Nong Wang, Dan Liu, Yan-Zhi Chen, Yu-Xia Zhao, Department of Gastric Cancer and Soft-Tissue Sacomas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Yan-Zhi
authors.initials: YZ
authors.lastname: Chen
authors.affiliation: Zi-Wen Long, Hong-Mei Yu, Ya-Nong Wang, Dan Liu, Yan-Zhi Chen, Yu-Xia Zhao, Department of Gastric Cancer and Soft-Tissue Sacomas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Yu-Xia
authors.initials: YX
authors.lastname: Zhao
authors.affiliation: Zi-Wen Long, Hong-Mei Yu, Ya-Nong Wang, Dan Liu, Yan-Zhi Chen, Yu-Xia Zhao, Department of Gastric Cancer and Soft-Tissue Sacomas Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Bai
mesh_terms: D001208:Asia / Q000453:epidemiology; D044466:Asian People / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology
chemical_list: D020381:Interleukin-17
keywords: Asian populations; Gastric cancer; Genetic polymorphism; IL-17; Meta-analysis