title: Cognitive insight in first-episode schizophrenia: further evidence for a role of the ventrolateral prefrontal cortex.
abstract: In people with psychoses, Self-Reflectiveness may rely on the right ventrolateral prefrontal cortex (VLPFC). We used functional magnetic resonance imaging (fMRI) and a novel virtual reality paradigm to evaluate the role of the VLPFC for Self-Reflectiveness in 25 first-episode of schizophrenia (FES) participants and 24 controls. Participants first viewed 20 characters each paired with a unique object/location, and later completed source memory judgements during fMRI scanning. Self-Reflectiveness, measured with the Beck Cognitive Insight Scale, was significantly and positively correlated to activation in bilateral VLPFC in FES, but not in controls, providing further evidence that the VLPFC supports Self-Reflectiveness in FES.
authors.affiliation: Department of Psychiatry, University of Calgary, Alberta, Canada.
authors.forename: Lisa
authors.initials: L
authors.lastname: Buchy
authors.affiliation: Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Ontario, Canada.
authors.forename: Colin
authors.initials: C
authors.lastname: Hawco
authors.affiliation: Prevention and Early Intervention Program for Psychoses, Douglas Mental Health University Institute, Verdun, Canada.
authors.forename: Ridha
authors.initials: R
authors.lastname: Joober
authors.affiliation: Prevention and Early Intervention Program for Psychoses, Douglas Mental Health University Institute, Verdun, Canada.
authors.forename: Ashok
authors.initials: A
authors.lastname: Malla
authors.affiliation: Prevention and Early Intervention Program for Psychoses, Douglas Mental Health University Institute, Verdun, Canada; Department of Psychiatry, McGill University, Montreal, Canada; Department of Neurology & Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada. Electronic address: martin.lepage@mcgill.ca.
authors.forename: Martin
authors.initials: M
authors.lastname: Lepage
mesh_terms: D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D007600:Judgment / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012649:Self Concept; D055815:Young Adult
keywords: Cognitive insight; First-episode psychosis; Self-certainty; Self-reflectiveness; Ventrolateral prefrontal cortex