title: Evaluation of the validity of chemotherapy-induced nausea and vomiting assessment in outpatients using the Japanese version of the MASCC antiemesis tool.
abstract: OBJECTIVE
  The Multinational Association of Supportive Care in Cancer (MASCC) developed the MASCC antiemesis tool (MAT) as a tool for chemotherapy-induced nausea and vomiting (CINV) assessment and subsequently published its Japanese version in 2010. We evaluated the validity of CINV assessment in outpatients using the Japanese version of MAT.
  
  
  METHODS
  Patients administered highly or moderately emetogenic chemotherapy in the outpatient chemotherapy unit of our hospital were included in the study. The study was designed as a prospective two-period crossover observational study to evaluate the correlation between the daily patient diary and the Japanese version of MAT in terms of CINV onset. We examined with a focus on reliability of the Japanese version of MAT particularly in the description of the delayed phase of nausea and vomiting.
  
  
  RESULTS
  Patient descriptions of CINV onset in a total of 116 cycles in 58 patients (two cycles/patient) were analyzed. The CINV incidence indicated by the patient diary was similar to that by the Japanese version of MAT. The concordance rate between the two tools in the same patients was 86.2 % for CINV onset in the delayed phase. The nausea score was also similar between the two tools regarding the mean and variance, showing a strong correlation with a correlation coefficient of 0.71.
  
  
  CONCLUSIONS
  The results of the study showed that the Japanese version of MAT is a highly reliable tool for CINV assessment, indicating that it is valid for assessing CINV in outpatients.
authors.affiliation: Department of Nursing, Outpatient Chemotherapy Center, Sapporo Medical University, South 1, West 16, Chuo-ku, Sapporo, 060-8543, Japan.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Matsuda
authors.affiliation: Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan. okita@sapmed.ac.jp.
authors.forename: Kenji
authors.initials: K
authors.lastname: Okita
authors.affiliation: Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Furuhata
authors.affiliation: Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
authors.forename: Goro
authors.initials: G
authors.lastname: Kutomi
authors.affiliation: Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yamashita
authors.affiliation: Department of Medical Oncology and Hematology, Sapporo Medical University, Sapporo, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Medical Oncology and Hematology, Sapporo Medical University, Sapporo, Japan.
authors.forename: Rishu
authors.initials: R
authors.lastname: Takimoto
authors.affiliation: Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects; D018592:Cross-Over Studies; D005260:Female; D006761:Hospitals; D006801:Humans; D015994:Incidence; D007564:Japan; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D010045:Outpatients; D011446:Prospective Studies; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014839:Vomiting / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents
keywords: Antiemetics; Chemotherapy-induced nausea and vomiting; MASCC antiemesis tool; Symptom evaluation