title: Simultaneous transplantation of limbal stem cells may reduce recurrences of granular dystrophy after corneal transplantation: 2 long-term case reports.
abstract: To present 2 cases with long-term relapse-free intervals only after limbo-keratoplasty but not after conventional penetrating keratoplasty in granular dystrophy.Retrospective review of the patient charts and photographs taken during long-term follow-up of 2 cases with granular dystrophy, in which 1 eye received penetrating keratoplasty and the fellow eye received penetrating limbo-keratoplasty.In the first patient, 1 eye showed extensive recurrence of granular deposits 17 years after penetrating keratoplasty was performed while in the second eye two-thirds of the corneal transplant adjacent to the transplanted limbal area remained clear 12 years after the limbo-corneal transplant. In the second patient, 1 eye showed no signs of recurrence 5 years after limbo-keratoplasty, whereas a recurrence of granular corneal deposits occurred 18 months after surgery in the fellow eye.These cases show that the simultaneous transplantation of healthy donor limbus when performing penetrating keratoplasty may prolong recurrence in granular corneal dystrophy. Although we were unable to prove it on the molecular level, these clinical courses may support the hypothesis that a limbal transplant helps prevent a recurrence.
authors.affiliation: From the Eye Center, Albert-Ludwigs-University of Freiburg, Freiburg, Germany (TR, RS); Pallas Clinic Olten, Olten, Switzerland (SJL, PE).
authors.forename: Stefan J
authors.initials: SJ
authors.lastname: Lang
authors.forename: Philipp
authors.initials: P
authors.lastname: Eberwein
authors.forename: Helga
authors.initials: H
authors.lastname: Reinshagen
authors.forename: Thomas
authors.initials: T
authors.lastname: Reinhard
authors.forename: Rainer
authors.initials: R
authors.lastname: Sundmacher
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003317:Corneal Dystrophies, Hereditary / Q000517:prevention & control / Q000601:surgery*; D016039:Corneal Transplantation / Q000379:methods*; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000379:methods; D008297:Male; D012008:Recurrence; D033581:Stem Cell Transplantation / Q000379:methods*