title: Influence of preoperative peripheral parenteral nutrition with micronutrients after colorectal cancer patients.
abstract: BACKGROUND
  The inflammatory reactions are stronger after surgery of malnourished preoperative patients. Many studies have shown vitamin and trace element deficiencies appear to affect the functioning of immune cells. Enteral nutrition is often inadequate for malnourished patients. Therefore, total parenteral nutrition (TPN) is considered an effective method for providing preoperative nutritional support. TPN needs a central vein catheter, and there are more risks associated with TPN. However, peripheral parenteral nutrition (PPN) often does not provide enough energy or nutrients.
  
  
  OBJECTIVE
  This study investigated the inflammatory response and prognosis for patients receiving a modified form of PPN with added fat emulsion infusion, multiple vitamins (MTV), and trace elements (TE) to assess the feasibility of preoperative nutritional support. Methods. A cross-sectional design was used to compare the influence of PPN with or without adding MTV and TE on malnourished abdominal surgery patients.
  
  
  RESULTS
  Both preoperative groups received equal calories and protein, but due to the lack of micronutrients, patients in preoperative Group B exhibited higher inflammation, lower serum albumin levels, and higher anastomotic leak rates and also required prolonged hospital stays.
  
  
  CONCLUSIONS
  Malnourished patients who receive micronutrient supplementation preoperatively have lower postoperative inflammatory responses and better prognoses. PPN with added fat emulsion, MTV, and TE provides valid and effective preoperative nutritional support.
authors.affiliation: Department of Nutrition, Tainan Sin-Lau Hospital, No. 57, Sec. 1, Dongmen Road, Tainan 70142, Taiwan.
authors.forename: Ming-Yi
authors.identifier: 0000-0002-1421-6289
authors.initials: MY
authors.lastname: Liu
authors.affiliation: Department of Surgery, Tainan Sin-Lau Hospital, No. 57, Sec. 1, Dongmen Road, Tainan 70142, Taiwan.
authors.forename: Hsiu-Chih
authors.initials: HC
authors.lastname: Tang
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan ; Department of Nutrition and Dietetics, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan.
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Hu
authors.affiliation: Department of Nursing, Tainan Sin-Lau Hospital, No. 57, Sec. 1, Dongmen Road, Tainan 70142, Taiwan.
authors.forename: Hui-Lan
authors.initials: HL
authors.lastname: Yang
authors.affiliation: Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan.
authors.forename: Sue-Joan
authors.identifier: 0000-0002-9651-4262
authors.initials: SJ
authors.lastname: Chang
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000601:surgery* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D044342:Malnutrition / Q000175:diagnosis; D018977:Micronutrients / Q000627:therapeutic use*; D009752:Nutritional Status; D010288:Parenteral Nutrition; D011184:Postoperative Period; D011300:Preoperative Care; D016896:Treatment Outcome
chemical_list: D018977:Micronutrients