title: Impact of minimum contrast media volumes during elective percutaneous coronary intervention for prevention of contrast-induced nephropathy in patients with stable coronary artery disease.
abstract: Contrast-induced nephropathy (CIN) is an important complication following percutaneous coronary intervention (PCI). The clinical importance of a minimum contrast media volume (CMV) for PCI to prevent CIN has not been well evaluated. The purpose of this study was to evaluate the impact of minimum CMV to prevent CIN after PCI. In this study, 2052 consecutive patients who underwent elective PCI in our institute were analyzed. We divided patients into two groups according to CMV: a minimum CMV PCI group [CMV ≤50 ml (n = 94)] and a non-minimum CMV PCI group [CMV >50 ml (n = 1958)]. CIN occurred in 160 (7.8 %) patients. The incidence of CIN was significantly lower in the minimum CMV PCI group than in the non-minimum CMV PCI group (2.1 vs. 8.1 %; P = 0.03). According to multivariate analysis, elderly patients and diabetes mellitus patients were at high risk of developing CIN in this study population. When analyzing only high-risk patients, the incidence of CIN was also significantly lower in the minimum CMV group than in the non-minimum CMV group (2.6 vs. 10.3 %; P = 0.03). Minimum CMV PCI could reduce the incidence of CIN, particularly in high-risk patients; as such, defining the minimum CMV clinical cut-off values may be useful for the prevention of CIN.
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, 21-1 Gobudori, Oyama Cho, Toyohashi, 441-8350, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ebisawa
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, 21-1 Gobudori, Oyama Cho, Toyohashi, 441-8350, Japan. k_siho_yuu@hotmail.com.
authors.forename: Tairo
authors.initials: T
authors.lastname: Kurita
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, 21-1 Gobudori, Oyama Cho, Toyohashi, 441-8350, Japan.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Tanaka
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, 21-1 Gobudori, Oyama Cho, Toyohashi, 441-8350, Japan.
authors.forename: Kenya
authors.initials: K
authors.lastname: Nasu
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, 21-1 Gobudori, Oyama Cho, Toyohashi, 441-8350, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Kimura
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, 21-1 Gobudori, Oyama Cho, Toyohashi, 441-8350, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ito
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, 21-1 Gobudori, Oyama Cho, Toyohashi, 441-8350, Japan.
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kinoshita
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, 21-1 Gobudori, Oyama Cho, Toyohashi, 441-8350, Japan.
authors.forename: Etsuo
authors.initials: E
authors.lastname: Tsuchikane
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, 21-1 Gobudori, Oyama Cho, Toyohashi, 441-8350, Japan.
authors.forename: Mitsuyasu
authors.initials: M
authors.lastname: Terashima
authors.affiliation: Department of Cardiology, Toyohashi Heart Center, 21-1 Gobudori, Oyama Cho, Toyohashi, 441-8350, Japan.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000367:Age Factors; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage*; D003324:Coronary Artery Disease / Q000628:therapy*; D003404:Creatinine / Q000097:blood; D048909:Diabetes Complications; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D015994:Incidence; D007552:Isotonic Solutions / Q000627:therapeutic use; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D008297:Male; D015999:Multivariate Analysis; D062645:Percutaneous Coronary Intervention; D012189:Retrospective Studies; D012307:Risk Factors; D017693:Sodium Bicarbonate / Q000627:therapeutic use
chemical_list: D003287:Contrast Media; D007552:Isotonic Solutions; D017693:Sodium Bicarbonate; D003404:Creatinine
keywords: Contrast media volume; Contrast-induced nephropathy; Percutaneous coronary intervention