title: Innate lymphoid cells are pivotal actors in allergic, inflammatory and autoimmune diseases.
abstract: Innate lymphoid cells (ILCs) are lymphoid cells that do not express V(D)J-rearranged receptors and play a role in the innate immune system. ILCs are categorized into three groups with respect to their function in the immune system. ILC1 induces production of IFN-γ via T-box expressed on T cells, ILC2 promotes production of type 2 cytokines via GATA-binding protein-3 and ILC3 promotes IL-17 and IL-22 production via retinoic acid receptor-related orphan receptor-γt. ILCs can maintain homeostasis in epithelial surfaces by responding to locally produced cytokines or direct recognition of danger patterns. Altered epithelial barrier function seems to be a key point in inappropriate activation of ILCs to promote inflammatory and allergic responses. ILCs play an essential role in initiation and maintenance of defense against infections as well as immune-mediated diseases. In this paper, we discuss the role of ILCs in inflammatory, allergic and autoimmune diseases.
authors.affiliation: Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Golshid
authors.initials: G
authors.lastname: Sanati
authors.forename: Zahra
authors.initials: Z
authors.lastname: Aryan
authors.forename: Mehri
authors.initials: M
authors.lastname: Barbadi
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism; D004847:Epithelial Cells / Q000276:immunology; D006706:Homeostasis; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000378:metabolism
chemical_list: D016207:Cytokines; D051192:Receptors, Pattern Recognition
keywords: disease; immunity; innate lymphoid cells