title: [Identification and characterization of HIV-1 transmitted /founder viruses].
abstract: During the spread of human immunodeficiency virus type 1 (HIV-1) in the mucosa, the entire genetic diversity of the viruses is significantly reduced. The vast majority of HIV-1 mucosal infections are established by one or a few viruses and ultimately develop into systemic infections, thus the initial virus is called transmitted/founder virus (T/F virus). The study of T/F virus will benefit understanding its key characteristics resulting in successful viral replication in the new host body, which may provide novel strategies for the development of AIDS vaccines, pre-exposure prophylaxis and other therapeutic interventions. In this review, we summarize the discovery and evolutionary characteristics of T/F virus as well as early immune response after HIV-1 infection, which will establish the basis to explore the features of T/F viruses.
authors.affiliation: 1. Department of Food Science, College of Arts & Science of Beijing Union University, Beijing 100192, China 2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical School, Beijing 100050, China;
authors.forename: Jian-yuan
authors.initials: JY
authors.lastname: Zhao
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical School, Beijing 100050, China.
authors.forename: Ji-wei
authors.initials: JW
authors.lastname: Ding
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical School, Beijing 100050, China.
authors.forename: Ze-yun
authors.initials: ZY
authors.lastname: Mi
authors.affiliation: Department of Food Science, College of Arts & Science of Beijing Union University, Beijing 100192, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wei
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical School, Beijing 100050, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Cen
mesh_terms: D000818:Animals; D015658:HIV Infections / Q000276:immunology / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D014779:Virus Replication