title: Reversible Amisulpride-induced Elevation of Creatine Kinase (CK): A Case Series from the German AMSP Pharmacovigilance Project.
abstract: The elevation of creatine kinase (CK) levels without neuroleptic malignant syndrome has been reported for several antipsychotics. We present here 4 cases with CK elevation induced by amisulpride, which have been registered for the German pharmacovigilance project, Arzneimittelsicherheit in der Psychiatrie (AMSP). The magnitude of the CK elevation ranged between 1, 498 IU/L and 21,018 IU/L. All 4 patients reported myalgia. In each case CK returned to normal after amisulpride discontinuation. In the fourth case, fluids were administered intravenously in order to prevent acute renal failure. None of the cases showed deterioration of renal function. Finally, we present recommendations for clinical practice.
authors.affiliation: Department of Psychiatry and Psychotherapy, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany.
authors.forename: Z G
authors.initials: ZG
authors.lastname: Laoutidis
authors.affiliation: Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Konstantinidis
authors.affiliation: Department of Psychiatry, Ludwig Maximilian University of Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Grohmann
authors.affiliation: Department of Psychiatry and Psychotherapy, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Luckhaus
authors.affiliation: Department of Psychiatry and Psychotherapy, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Mobascher
authors.affiliation: Department of Psychiatry and Psychotherapy, Medical Faculty of Heinrich Heine University, Düsseldorf, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Cordes
mesh_terms: D000328:Adult; D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063806:Myalgia / Q000139:chemically induced*; D012559:Schizophrenia / Q000188:drug therapy; D013469:Sulpiride / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D013469:Sulpiride; D000077582:Amisulpride; D003402:Creatine Kinase