title: The relation between platelet-to-lymphocyte ratio and Pulmonary Embolism Severity Index in acute pulmonary embolism.
abstract: OBJECTIVE
  In this study, we aimed to investigate the value of the platelet-to-lymphocyte ratio (PLR) for predicting disease severity based on simplified Pulmonary Embolism Severity Index (sPESI), as well as in-hospital mortality in patients with acute pulmonary embolism (APE).
  
  
  METHODS
  Our hospital's electronic patient database was searched for the patients with ICD-9 code I26, and eligible 646 patients were included in the study.
  
  
  RESULTS
  Univariate logistic regression analysis showed that PLR, pulmonary artery systolic pressure, right ventricular dysfunction, D-dimer level, and white blood cell, lymphocyte, platelet and neutrophil counts were significantly correlated with a high sPESI score in patients with APE.
  
  
  CONCLUSIONS
  To the best of our knowledge, this is the first study in the literature showing that a high PLR is independently associated with a high risk of mortality in patients with APE.
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey. Electronic address: harunkundi@hotmail.com.
authors.forename: Harun
authors.initials: H
authors.lastname: Kundi
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Balun
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Cicekcioglu
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Emrullah
authors.initials: E
authors.lastname: Kiziltunc
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Zehra Guven
authors.initials: ZG
authors.lastname: Cetin
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Candan
authors.initials: C
authors.lastname: Mansuroglu
authors.affiliation: Department of Cardiology, Ankara Numune Education and Research Hospital, Ankara, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Ornek
mesh_terms: D000208:Acute Disease; D001792:Blood Platelets; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D017052:Hospital Mortality; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010976:Platelet Count; D011379:Prognosis; D011655:Pulmonary Embolism / Q000473:pathology*; D012372:ROC Curve; D012307:Risk Factors; D012720:Severity of Illness Index; D018497:Ventricular Dysfunction, Right / Q000473:pathology
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D
keywords: Acute pulmonary embolism; Inflammation; Platelet function; Platelet-lymphocyte ratio; Simplified pulmonary embolism severity