title: Porcine models of cutaneous wound healing.
abstract: Cutaneous wound healing in the pig is frequently used as a model for human cutaneous wound healing. In this review, we examine the appropriateness of this model for studying normal and pathological wound healing, and describe models for chronic nonhealing wounds, diabetic wounds, burns, and hypertrophic scars. In addition, we focus on studies that have used pigs to evaluate wound-healing therapies, and discuss genetic engineering technology in the pig that may advance our knowledge of wound healing. We conclude that, although not perfect, the pig offers a versatile model that can be adjusted to mimic a wide range of clinical scenarios.
authors.affiliation: Max Seaton, MD, is a general surgery resident at the University of Maryland Medical Center in Baltimore, Maryland, and a research fellow in the Department of Surgery at the University of Washington, in Seattle, Washington. Anne Hocking, PhD, is a research associate professor in the Department of Surgery at the University of Washington. Nicole S. Gibran, MD, FACS, is a professor in the Department of Surgery at the University of Washington and Director of the Burn Center at Harborview Medical Center, in Seattle, Washington.
authors.forename: Max
authors.initials: M
authors.lastname: Seaton
authors.affiliation: Max Seaton, MD, is a general surgery resident at the University of Maryland Medical Center in Baltimore, Maryland, and a research fellow in the Department of Surgery at the University of Washington, in Seattle, Washington. Anne Hocking, PhD, is a research associate professor in the Department of Surgery at the University of Washington. Nicole S. Gibran, MD, FACS, is a professor in the Department of Surgery at the University of Washington and Director of the Burn Center at Harborview Medical Center, in Seattle, Washington.
authors.forename: Anne
authors.initials: A
authors.lastname: Hocking
authors.affiliation: Max Seaton, MD, is a general surgery resident at the University of Maryland Medical Center in Baltimore, Maryland, and a research fellow in the Department of Surgery at the University of Washington, in Seattle, Washington. Anne Hocking, PhD, is a research associate professor in the Department of Surgery at the University of Washington. Nicole S. Gibran, MD, FACS, is a professor in the Department of Surgery at the University of Washington and Director of the Burn Center at Harborview Medical Center, in Seattle, Washington.
authors.forename: Nicole S
authors.initials: NS
authors.lastname: Gibran
mesh_terms: D000818:Animals; D002056:Burns / Q000473:pathology; D004195:Disease Models, Animal; D013552:Swine; D014945:Wound Healing / Q000502:physiology*
keywords: burns; chronic wounds; diabetic wounds; hypertrophic scar; pig model; porcine model; wound healing