title: Association Analysis of COQ2 Variant in Dementia and Essential Tremor.
abstract: Objective. COQ2 mutations have been reported in Japanese multiple system atrophy (MSA) patients. We examined the role of COQ2 in patients with dementia and essential tremor (ET), two common neurodegenerative conditions. Materials & Methods. A total of 2064 subjects, including 560 patients with dementia, 466 patients with ET, and 1038 healthy controls, were included. Genotyping for the COQ2 V393A (T>C) was carried out. Odds ratio (OR) adjusted by age and gender, together with 95% confidence interval (CI), was reported by means of logistic regression. Results. The frequency of the polymorphic variant V393A heterozygous (T/C) was 2.7% in dementia, 1.1% in ET, and 2.5% in controls (OR = 0.70, 95% confidence interval is 0.29-1.72 for dementia, and OR = 0.47, 95% confidence interval is 0.17-1.31, p = 0.1217 for ET). There was no significant association between V393A variant with dementia and ET. Conclusion. There was no significant association between V393A variant with dementia and ET. COQ2 gene is unlikely to play a significant role in patients with dementia or ET in our population.
authors.affiliation: Department of Neurology, Singapore General Hospital, Singapore 169608 ; National Neuroscience Institute, Singapore 308433.
authors.forename: Yin Xia
authors.identifier: 0000-0003-1185-3511
authors.initials: YX
authors.lastname: Chao
authors.affiliation: Department of Neurology, Singapore General Hospital, Singapore 169608 ; National Neuroscience Institute, Singapore 308433.
authors.forename: Ebonne Yu Lin
authors.initials: EY
authors.lastname: Ng
authors.affiliation: Duke-NUS Graduate Medical School, Singapore 169857.
authors.forename: Huihua
authors.initials: H
authors.lastname: Li
authors.affiliation: National Neuroscience Institute, Singapore 308433.
authors.forename: Kandiah
authors.initials: K
authors.lastname: Nagaendran
authors.affiliation: Health Assessment Centre, Singapore General Hospital, Singapore 169608 ; Health Services Research, Singapore General Hospital, Singapore 169608.
authors.forename: Yuen
authors.initials: Y
authors.lastname: Yih
authors.affiliation: Institute of Geriatrics and Active Ageing, Tan Tock Seng Hospital, Singapore 308433.
authors.forename: Mei Sian
authors.identifier: 0000-0001-9324-5901
authors.initials: MS
authors.lastname: Chong
authors.affiliation: Department of Neurology, Singapore General Hospital, Singapore 169608 ; National Neuroscience Institute, Singapore 308433.
authors.forename: Kumar M
authors.initials: KM
authors.lastname: Prakash
authors.affiliation: National Neuroscience Institute, Singapore 308433.
authors.forename: Louis
authors.initials: L
authors.lastname: Tan
authors.affiliation: National Neuroscience Institute, Singapore 308433.
authors.forename: Wing Lok
authors.initials: WL
authors.lastname: Au
authors.affiliation: Department of Clinical Research, Singapore General Hospital, Singapore 169608.
authors.forename: Yi
authors.identifier: 0000-0002-3839-6499
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Singapore General Hospital, Singapore 169608 ; National Neuroscience Institute, Singapore 308433.
authors.forename: Zhi Dong
authors.identifier: 0000-0001-8480-9939
authors.initials: ZD
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Singapore General Hospital, Singapore 169608 ; National Neuroscience Institute, Singapore 308433.
authors.forename: Murni
authors.initials: M
authors.lastname: Tio
authors.affiliation: Department of Neurology, Singapore General Hospital, Singapore 169608 ; National Neuroscience Institute, Singapore 308433.
authors.forename: Ratnagopal
authors.initials: R
authors.lastname: Pavanni
authors.affiliation: Department of Neurology, Singapore General Hospital, Singapore 169608 ; National Neuroscience Institute, Singapore 308433 ; Duke-NUS Graduate Medical School, Singapore 169857 ; Department of Clinical Research, Singapore General Hospital, Singapore 169608.
authors.forename: Eng King
authors.initials: EK
authors.lastname: Tan