title: Collateral DNA damage produced by genome-editing drones: exception or rule?
abstract: In the recent issue of Nature Biotechnology, Frock et al. (2015) developed an elegant technique to capture translocation partners that can be utilized to determine off-target regions of genome-editing endonucleases as well as endogenous mutators at nucleotide resolution.
authors.affiliation: Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Andres
authors.initials: A
authors.lastname: Canela
authors.affiliation: Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
authors.forename: Andre
authors.initials: A
authors.lastname: Stanlie
authors.affiliation: Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: andre_nussenzweig@nih.gov.
authors.forename: André
authors.initials: A
authors.lastname: Nussenzweig
mesh_terms: D064113:CRISPR-Cas Systems / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D053903:DNA Breaks, Double-Stranded; D004720:Endonucleases / Q000235:genetics*; D006801:Humans
chemical_list: D004247:DNA; D004720:Endonucleases