title: Antidiabetic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats.
abstract: The present study investigated and compared the hypoglycemic activity of differently regioselective chitosan sulfates in alloxan-induced diabetic rats. Compared with the normal control rats, significantly higher blood glucose levels were observed in the alloxan-induced diabetic rats. The differently regioselective chitosan sulfates exhibited hypoglycemic activities at different doses and intervals, especially 3-O-sulfochitosan (3-S). The major results are as follows. First, 3,6-di-O-sulfochitosan and 3-O-sulfochitosan exhibited more significant hypoglycemic activities than 2-N-3, 6-di-O-sulfochitosan and 6-O-sulfochitosan. Moreover, 3-S-treated rats showed a more significant reduction of blood glucose levels than those treated by 3,6-di-O-sulfochitosan. These results indicated that -OSO3- at the C3-position of chitosan is a key active site. Second, 3-S significantly reduced the blood glucose levels and regulated the glucose tolerance effect in the experimental rats. Third, treatment with 3-S significantly increased the plasma insulin levels in the experimental diabetic rats. A noticeable hypoglycemic activity of 3-S in the alloxan-induced diabetic rats was shown. Clinical trials are required in the future to confirm the utility of 3-S.
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. xingronge@qdio.ac.cn.
authors.forename: Ronge
authors.initials: R
authors.lastname: Xing
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. hexiaofei12@mails.ucas.ac.cn.|College of Earth Science, University of the Chinese Academy of Sciences, Beijing 100049, China. hexiaofei12@mails.ucas.ac.cn.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: He
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. sliu@qdio.ac.cn.
authors.forename: Song
authors.initials: S
authors.lastname: Liu
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. yuhuahua@qdio.ac.cn.
authors.forename: Huahua
authors.initials: H
authors.lastname: Yu
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. ykqin@qdio.ac.cn.
authors.forename: Yukun
authors.initials: Y
authors.lastname: Qin
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. chenxl@qdio.ac.cn.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. lkc@qdio.ac.cn.
authors.forename: Kecheng
authors.initials: K
authors.lastname: Li
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. rongfengli@qdio.ac.cn.
authors.forename: Rongfeng
authors.initials: R
authors.lastname: Li
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. pcli@qdio.ac.cn.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Li
mesh_terms: D000496:Alloxan / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D048271:Chitosan / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy*; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; C480355:chitosan sulfate; D000496:Alloxan; D048271:Chitosan
keywords: alloxan-induced diabetic rats; differently regioselective chitosan sulfates; glucose tolerance; hypoglycemic activity; plasma insulin