title: Inexhaustible hair-cell regeneration in young and aged zebrafish.
abstract: Animals have evolved two general strategies to counter injury and maintain physiological function. The most prevalent is protection by isolating vital organs into body cavities. However, protection is not optimal for sensory systems because their external components need to be exposed to the environment to fulfill their receptive function. Thus, a common strategy to maintain sensory abilities against persistent environmental insult involves repair and regeneration. However, whether age or frequent injuries affect the regenerative capacity of sensory organs remains unknown. We have found that neuromasts of the zebrafish lateral line regenerate mechanosensory hair cells after recurrent severe injuries and in adulthood. Moreover, neuromasts can reverse transient imbalances of Notch signaling that result in defective organ proportions during repair. Our results reveal inextinguishable hair-cell regeneration in the lateral line, and suggest that the neuromast epithelium is formed by plastic territories that are maintained by continuous intercellular communication.
authors.affiliation: Laboratory of Sensory Cell Biology & Organogenesis, Centre for Genomic Regulation, Dr. Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Filipe
authors.initials: F
authors.lastname: Pinto-Teixeira
authors.affiliation: Laboratory of Sensory Cell Biology & Organogenesis, Centre for Genomic Regulation, Dr. Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Oriol
authors.initials: O
authors.lastname: Viader-Llargués
authors.affiliation: Laboratory of Sensory Cell Biology & Organogenesis, Centre for Genomic Regulation, Dr. Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Elen
authors.initials: E
authors.lastname: Torres-Mejía
authors.affiliation: Laboratory of Sensory Cell Biology & Organogenesis, Centre for Genomic Regulation, Dr. Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Melissa
authors.initials: M
authors.lastname: Turan
authors.affiliation: Laboratory of Sensory Cell Biology & Organogenesis, Centre for Genomic Regulation, Dr. Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Estela
authors.initials: E
authors.lastname: González-Gualda
authors.affiliation: Laboratory of Sensory Cell Biology & Organogenesis, Centre for Genomic Regulation, Dr. Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Pola-Morell
authors.affiliation: Laboratory of Sensory Cell Biology & Organogenesis, Centre for Genomic Regulation, Dr. Aiguader 88, 08003 Barcelona, Spain hernan.lopez-schier@helmholtz-muenchen.de.
authors.forename: Hernán
authors.initials: H
authors.lastname: López-Schier
keywords: Adult; Hair cells; Lateral line; Notch; Regeneration; Self organization