title: Local delivery of vascular endothelial growth factor via nanofiber matrix improves liver regeneration after extensive hepatectomy in rats.
abstract: Vascular endothelial growth factor (VEGF) is a potent regulator for liver regeneration following partial hepatectomy. However, intravenous delivery of VEGF has yielded limited success in promoting the regeneration of remnant liver. Here we report a new approach to locally deliver recombinant VEGF from an electrospun poly-ε-caprolactone nanofiber mesh and its effect on improving rat liver regeneration after 70% hepatectomy. After applying the VEGF-releasing nanofiber mesh to the remnant liver lobes following hepatectomy in rats, the fractions of proliferating hepatocytes increased markedly at 48 h and 72 h in comparison with the control group receiving nanofiber meshes without VEGF. The expression of endogenous VEGF in liver tissue was also higher in the VEGF-nanofiber group than those in the control group. These results demonstrate that biodegradable nanofiber meshes offer a convenient and effective approach for local and sustained delivery of VEGF to the remnant liver following partial hepatectomy.
authors.forename: Yuan-Quan
authors.initials: YQ
authors.lastname: Yu
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Jiang
authors.forename: Song
authors.initials: S
authors.lastname: Gao
authors.forename: Rui
authors.initials: R
authors.lastname: Ma
authors.forename: Yun
authors.initials: Y
authors.lastname: Jin
authors.forename: Xing
authors.initials: X
authors.lastname: Jin
authors.forename: Shu-You
authors.initials: SY
authors.lastname: Peng
authors.forename: Hai-Quan
authors.initials: HQ
authors.lastname: Mao
authors.forename: Jiang-Tao
authors.initials: JT
authors.lastname: Li
mesh_terms: D000818:Animals; D003131:Combined Modality Therapy; D004058:Diffusion; D004343:Drug Implants / Q000008:administration & dosage* / Q000737:chemistry; D006498:Hepatectomy; D008099:Liver / Q000166:cytology / Q000254:growth & development* / Q000601:surgery; D008115:Liver Regeneration / Q000187:drug effects / Q000502:physiology*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D051381:Rats; D013526:Surgical Mesh; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004343:Drug Implants; D053769:Nanocapsules; D042461:Vascular Endothelial Growth Factor A