title: Case Study: Diffuse Large B-Cell Lymphoma Arising in Ovarian Mature Cystic Teratoma.
abstract: We describe an unexpected finding of diffuse large B-cell lymphoma associated with mature cystic teratoma of the ovary. A 68-yr-old woman with a complex left ovarian cystic mass on imaging underwent bilateral salpingo-oophorectomy, lymphadenectomy, appendicectomy, and omentectomy. Histopathologic examination revealed nodules of malignant non-Hodgkin lymphoma within the teratoma. A diagnosis of diffuse large B-cell lymphoma, germinal center cell subtype by Hans criteria was made after immunostaining and molecular studies. The patient was treated with R-CHOP chemotherapy and remains disease-free at 14-mo follow-up.
authors.affiliation: Department of Histopathology (A.M., G.C., J.W., M.J., E.G., R.F.), Cancer Molecular Diagnostics (K.M., F.Q.) Departments of Oncology (N.O.) Haematology and Cancer Molecular Diagnostics (E.V.), St. James's Hospital, Dublin, Ireland.
authors.forename: Aoife
authors.initials: A
authors.lastname: Maguire
authors.forename: Giuseppa
authors.initials: G
authors.lastname: Castriciano
authors.forename: Jan
authors.initials: J
authors.lastname: Walker
authors.forename: Karen
authors.initials: K
authors.lastname: Molloy
authors.forename: Fiona
authors.initials: F
authors.lastname: Quinn
authors.forename: Nemer
authors.initials: N
authors.lastname: Osman
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Vandenberghe
authors.forename: Michael
authors.initials: M
authors.lastname: Jeffers
authors.forename: Eoin
authors.initials: E
authors.lastname: Gaffney
authors.forename: Richard
authors.initials: R
authors.lastname: Flavin
mesh_terms: D000368:Aged; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols; D001062:Appendectomy; D003520:Cyclophosphamide; D004317:Doxorubicin; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D009852:Omentum / Q000601:surgery; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D011241:Prednisone; D000069283:Rituximab; D058994:Salpingectomy; D013724:Teratoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D014750:Vincristine
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007136:Immunoglobulins; C571759:R-CHOP protocol; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone