title: Redox-neutral palladium-catalyzed C-H functionalization to form isoindolinones with carboxylic acids or anhydrides as readily available starting materials.
abstract: An operationally simple, Pd-catalyzed C-H functionalization is described for the synthesis of important and useful isoindolinones from readily available carboxamides and carboxylic acids or anhydrides. The reactions proceed efficiently with a broad range of substrates under redox-neutral reaction conditions and tolerate a diversity of functional groups. The mechanistic investigation suggests that the reactions involve C-H activation, nucleophilic addition, β-O elimination, and dehydration steps.
authors.affiliation: †College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
authors.forename: Hong-Wen
authors.initials: HW
authors.lastname: Liang
authors.affiliation: †College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Ding
authors.affiliation: †College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Jiang
authors.affiliation: †College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shuai
authors.affiliation: †College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: †College of Pharmacy, Third Military Medical University, Chongqing 400038, China.|‡State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Wei
authors.affiliation: †College of Pharmacy, Third Military Medical University, Chongqing 400038, China.
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D006860:Hydrogen Bonding; D054833:Isoindoles / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry
chemical_list: D000812:Anhydrides; D002264:Carboxylic Acids; C110621:Isoindol-1-one; D054833:Isoindoles; D010165:Palladium