title: Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults.
abstract: OBJECTIVE
  The gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence.
  
  
  METHODS
  The present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18-26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA).
  
  
  RESULTS
  Two single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group.
  
  
  CONCLUSIONS
  These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.
authors.affiliation: Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Long
authors.affiliation: Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia.|Department of Actuarial and Risk Management, Karabük University, Karabük, Turkey.
authors.forename: Fazil
authors.initials: F
authors.lastname: Aliev
authors.affiliation: Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri.
authors.forename: Jen-Chyong
authors.initials: JC
authors.lastname: Wang
authors.affiliation: Departments of Biochemistry & Molecular Biology, Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Edenberg
authors.affiliation: Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana.
authors.forename: John
authors.initials: J
authors.lastname: Nurnberger
authors.affiliation: Department of Psychiatry, University of Connecticut Health Center, Farmington, Connecticut.
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
authors.affiliation: Department of Psychiatry and Behavioral Sciences, State University of New York (SUNY) Downstate Medical Center, Brooklyn, New York.
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.affiliation: Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia.
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Dick
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000235:genetics; D000437:Alcoholism / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D058068:Endophenotypes; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics*; D044465:White People / Q000235:genetics; D055815:Young Adult
chemical_list: D018094:Receptors, Metabotropic Glutamate; C111435:metabotropic glutamate receptor 8