title: Cancer stem cells and their vascular niche: Do they benefit from each other?
abstract: Cancer stem cells (CSCs) locate in and interact with particular vascular niches to maintain their stemness. CSCs induce, remodel and participate in the formation of microenvironmental niches to facilitate survival, stemness and escape from radio-/chemo-/bio-therapies. Neovasculature in tumor is often basement membrane-deficient and enriched with CSC-derived endothelial cells (ECs) and other mural cells, which may promote tumor invasion and metastasis. The aim of this review is to summarize recent findings about the crosstalk between CSCs and their vascular niches and discuss the potential therapeutic significance.
authors.affiliation: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing 400038, China. Electronic address: pingyifang@126.com.
authors.forename: Yi-Fang
authors.initials: YF
authors.lastname: Ping
authors.affiliation: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing 400038, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China; Key Laboratory of Tumor Immunopathology, Ministry of Education of China, Chongqing 400038, China. Electronic address: bianxiuwu@263.net.
authors.forename: Xiu-Wu
authors.initials: XW
authors.lastname: Bian
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D042501:Angiogenic Proteins / Q000378:metabolism; D000818:Animals; D019008:Drug Resistance, Neoplasm; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic; D019899:Paracrine Communication / Q000187:drug effects; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins
keywords: Cancer stem cells; Endothelial cells; Therapeutic significance; Tumor microenvironment; Vascular niches