title: In vivovolumetric depth-resolved vasculature imaging of human limbus and sclera with 1μm swept source phase-variance optical coherence angiography.
abstract: We present nnnnnin vivovolumetric depth-resolved vasculature images of the anterior segment of the human eye acquired with phase-variance based motion contrast using a high-speed (100 kHz, 105A-scans/s) swept source optical coherence tomography system (SSOCT). High phase stability SSOCT imaging was achieved by using a computationally efficient phase stabilization approach. The human corneo-scleral junction and sclera were imaged with swept source phase-variance optical coherence angiography and compared with slit lamp images from the same eyes of normal subjects. Different features of the rich vascular system in the conjunctiva and episclera were visualized and described. This system can be used as a potential tool for ophthalmological research to determine changes in the outflow system, which may be helpful for identification of abnormalities that lead to glaucoma.
authors.affiliation: Department of Bio-Engineering, Birla Institute of Technology-Mesra, Ranchi, JH 835 215, India.
authors.forename: Raju
authors.initials: R
authors.lastname: Poddar
authors.affiliation: Vision Science and Advanced Retinal Imaging Laboratory, Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA 95817, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Zawadzki
authors.affiliation: Vision Science and Advanced Retinal Imaging Laboratory, Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA 95817, USA ; Department of Ophthalmology, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Cortés
authors.affiliation: Vision Science and Advanced Retinal Imaging Laboratory, Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA 95817, USA.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Mannis
authors.affiliation: Vision Science and Advanced Retinal Imaging Laboratory, Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA 95817, USA.
authors.forename: John S
authors.initials: JS
authors.lastname: Werner
keywords: imaging systems; medical and biological imaging; ophthalmology; optical coherence tomography