title: The effects of particle shape and size on T2 relaxation in magnetic resonance imaging.
abstract: Superparamagnetic iron oxide nanoparticles have recently been developed as T2 contrast agents for magnetic resonance imaging. Here we report the dependence of the phase relaxivity, r2, on the particle shape. We show that the size dependence of the relaxivity for spherical particles can be generalized to spheroidal particles. In addition, we show that the saturation of relaxivity above a certain size observed in spherical particles does not occur in the spheroidal particles investigated.
authors.forename: Joseph N
authors.initials: JN
authors.lastname: York
authors.forename: Christopher
authors.initials: C
authors.lastname: Albanese
authors.forename: Olga
authors.initials: O
authors.lastname: Rodriguez
authors.forename: Yi-Chien
authors.initials: YC
authors.lastname: Le
authors.forename: Marian
authors.initials: M
authors.lastname: Ackun-Farmmer
authors.forename: Edward
authors.initials: E
authors.lastname: Van Keuren
mesh_terms: D003287:Contrast Media / Q000032:analysis* / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000032:analysis* / Q000737:chemistry*; D010316:Particle Size; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013329:Structure-Activity Relationship
chemical_list: D003287:Contrast Media; D058185:Magnetite Nanoparticles