title: Estimation of incidence, prevalence, and age-at-diagnosis of myasthenia gravis among adults by hospital discharge records.
abstract: BACKGROUND
  The Hungarian Health Insurance Fund, using appropriate information technology, covers all of the secondary care of the country and maintains a database of Hospital Discharge Records (HDR). Our study aimed to determine the incidence, average age-at-diagnosis (AaD), and prevalence of myasthenia gravis (MG) among adults and the regional heterogeneity of these measures to assess the potential usefulness of HDRs for monitoring.
  
  
  METHODS
  The nationwide database of 336,679 HDRs from 2004 to 2009 was analyzed. The incidence and prevalence were determined for adults in 2007. Patients with MG code in 2007, 2008, and 2009 but without that in 2004-2006 were defined as incident. Distribution of AaD was described for these cases. Patients with an MG code in 2007, 2008, and 2009 were defined as prevalent in 2007. The heterogeneity of regional age-standardized indices was tested.
  
  
  RESULTS
  The observed incidence and prevalence was 2.76/100,000 (men: 2.37/100,000; women: 3.11/100,000) and 17.42/100,000 (male: 13.08/100,000; female: 21.28/100,000), respectively. These estimates were within published ranges. The mean AaD was significantly higher for men than for women (63.60 vs. 51.92; p < 0.001). Significant regional heterogeneity was observed for all measures.
  
  
  CONCLUSIONS
  HDRs seem to be useful for developing MG indicators because they adequately estimate epidemiological parameters of MG occurrence.
authors.affiliation: Department of Preventive Medicine, Faculty of Public Health, University of Debrecen, PO Box 2, 4012, Debrecen, Hungary.
authors.forename: Anett
authors.initials: A
authors.lastname: Foldvari
authors.forename: Nora
authors.initials: N
authors.lastname: Kovacs
authors.forename: Valeria
authors.initials: V
authors.lastname: Sipos
authors.forename: Gabriella
authors.initials: G
authors.lastname: Merth
authors.forename: Ferenc
authors.initials: F
authors.lastname: Vincze
authors.forename: Maria
authors.initials: M
authors.lastname: Szucs
authors.forename: Janos
authors.initials: J
authors.lastname: Sandor
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000453:epidemiology*; D063886:Patient Discharge Summaries / Q000706:statistics & numerical data*; D011159:Population Surveillance / Q000379:methods*; D015995:Prevalence; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D055815:Young Adult