title: New monoterpene glycosides from sunflower seeds and their protective effects against H2O2-induced myocardial cell injury.
abstract: Three new monoterpene glycosides (1-3) and eleven known compounds (4-14) were isolated from seeds of Helianthus annuus L. (sunflower). Their structures were determined by spectroscopic and chemical methods. All the compounds were isolated from sunflower seeds for the first time. Protective effects of compounds 1-14 against H2O2-induced H9c2 cardiomyocyte injury were evaluated, and compounds 1 and 2 showed some cell-protective effects. No significant DPPH radical scavenging activity was observed for compounds 1-14.
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
authors.forename: Yonghe
authors.initials: Y
authors.lastname: Fei
authors.affiliation: National Center for Natural Products Research, and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS 38677, United States.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhao
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Liu
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
authors.forename: Xiaoran
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China. Electronic address: xuqiongming@suda.edu.cn.
authors.forename: Qiongming
authors.initials: Q
authors.lastname: Xu
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China; College of Chemical, Biological and Material Engineering, Suzhou Science and Technology University, Suzhou 215009, China. Electronic address: wangtaoyun@usts.edu.cn.
authors.forename: Taoyun
authors.initials: T
authors.lastname: Wang
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China; National Center for Natural Products Research, and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, MS 38677, United States.
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
authors.forename: Shilin
authors.initials: S
authors.lastname: Yang
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D016166:Free Radical Scavengers / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006368:Helianthus / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D039821:Monoterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D032383:Myocytes, Cardiac / Q000187:drug effects*; D010851:Picrates / Q000737:chemistry; D051381:Rats; D012639:Seeds / Q000737:chemistry
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006027:Glycosides; D039821:Monoterpenes; D010851:Picrates; D006861:Hydrogen Peroxide; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Cardiomyocytes oxidative injury; DPPH radical scavenging activity; Helianthus annuus L.; Monoterpene glycosides; Sunflower seed