title: Deltamethrin, a pyrethroid insecticide, could be a promising candidate as an anticancer agent.
abstract: Cancer is the one of the leading causes of death, whose incidences is increasing day by day. Various types of anticancer agents are used for its treatment, but unfortunately none of them is able to treat the cancer. Thus, the exploration of novel mechanistic pathways of existing molecules may help to develop more effective anticancer agents. Deltamethrin, at low concentration, is a safe pyrethroid insecticide that is widely used in the agriculture and home pest control. Recent in vitro and in vivo studies have shown that the deltamethrin have the potential to induce apoptogenic signaling pathways which plays an important role in the mechanism of anticancer action. Thus, deltamethrin thereof could have the potential to develop as an anticancer agent. Further both in vitro and in vivo evaluation of the therapeutic and toxic effects of this compound is needed for starting of clinical trial.
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India. Electronic address: abitmesra@gmail.com.
authors.forename: Anoop
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
authors.forename: Dinakar
authors.initials: D
authors.lastname: Sasmal
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India. Electronic address: nsharmabit@gmail.com.
authors.forename: Neelima
authors.initials: N
authors.lastname: Sharma
authors.affiliation: Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
authors.forename: Amand
authors.initials: A
authors.lastname: Bhaskar
authors.affiliation: Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
authors.forename: Saket
authors.initials: S
authors.lastname: Chandra
authors.affiliation: Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
authors.forename: Kunal
authors.initials: K
authors.lastname: Mukhopadhyay
authors.affiliation: Department of Bio-Engineering, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
authors.forename: Manish
authors.initials: M
authors.lastname: Kumar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D020013:Calcium Signaling / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D019317:Evidence-Based Medicine; D006801:Humans; D007306:Insecticides / Q000008:administration & dosage* / Q000737:chemistry; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D009570:Nitriles / Q000008:administration & dosage* / Q000737:chemistry; D011722:Pyrethrins / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin