title: Feasibility study of high-resolution DCE-MRI for glomerular filtration rate (GFR) measurement in a routine clinical modal.
abstract: Dynamic contrast enhanced (DCE) MR renography has been identified as an interesting tool to determine single-kidney GFR. However, a fundamental issue for the applicability of MR-based estimate of single-kidney GFR is selecting a balance between spatial and temporal resolution of DCE-MRI data. The purpose is to assess the feasibility of GFR estimate from high-resolution (HR) dynamic contrast-enhanced (DCE) MRI in a routine clinical modal. Standard MR renography (2.4s/phase, total 4min; 4-ml Gd) and five-phase, HR-based imaging protocol (0, 30, 70, 120, and 240s; 0.05mmol/kg Gd) were prospectively performed in twelve volunteers who were scheduled for routine renal MRI. Data were plotted with Patlak, two-compartment modified Tofts model (2CTM), and two-compartment filtration model (2CFM) for GFR estimate. During all the measurements, only the signal intensities in the aorta and whole kidney parenchyma were considered. Standard 2CFM and 2CTM produced lower residuals over the fitted interval than HR-based measures (p<0.05); and HR-bases 2CFM and 2CTM did not reflect significant correlation to standard values. Standard Patlak plots with 0-240s data points produced significantly lower GFR and higher residuals than that plots with 0-120s data points (p<0.05). HR-based Patlak plots with 0, 30, 70, and 120s data points significantly correlated with reference values (Pearson ρ=0.97, p<0.01), and produced a 33.2% underestimation of reference value, which was better than that plots with 0, 30, 70, 120, and 240s data points (ρ=0.92, p<0.01; 58.6% underestimation of reference value). It concludes that it is feasible to estimate GFR with HR-based DCE-MRI and appreciate kinetic model. Patlak plots from 0, 30, 70, and 120s data points is better than plots from 0, 30, 70, 120, and 240s data points.
authors.affiliation: Department of Radiology, the First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, Nanjing 210000, China. Electronic address: njmu_zyd@163.com.
authors.forename: Yu-Dong
authors.initials: YD
authors.lastname: Zhang
authors.affiliation: Department of Radiology, the First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, Nanjing 210000, China. Electronic address: njmu_wcj@163.com.
authors.forename: Chen-Jiang
authors.initials: CJ
authors.lastname: Wu
authors.affiliation: Department of Radiology, the First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, Nanjing 210000, China. Electronic address: njmu_zj@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, the First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, Nanjing 210000, China. Electronic address: njmu_wxn@163.com.
authors.forename: Xiao-Ning
authors.initials: XN
authors.lastname: Wang
authors.affiliation: Department of Radiology, the First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, Nanjing 210000, China. Electronic address: njmu_lxs@163.com.
authors.forename: Xi-Sheng
authors.initials: XS
authors.lastname: Liu
authors.affiliation: Department of Radiology, the First Affiliated Hospital with Nanjing Medical University, No. 300, Guangzhou Road, Nanjing 210000, China. Electronic address: njmu_shb@163.com.
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Shi
mesh_terms: D000328:Adult; D003198:Computer Simulation; D003287:Contrast Media / Q000493:pharmacokinetics; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007668:Kidney / Q000033:anatomy & histology / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA
keywords: 2CTM; GFR; MR renography; Patlak, 2CFM; Renal function