title: Association between Platelet-to-Lymphocyte Ratio and Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome.
abstract: OBJECTIVE
  Contrast-induced nephropathy (CIN) is associated with significantly increased morbidity and mortality after percutaneous coronary intervention (PCI). Patients with acute coronary syndrome (ACS) are at higher risk of CIN. The platelet-to-lymphocyte ratio (PLR) is closely linked to inflammatory conditions. We hypothesized that PLR levels on admission can predict the development of CIN after PCI for ACS.
  
  
  METHODS
  A total of 426 patients (mean age 63.17 ± 13.01 years, 61.2% males) with ACS undergoing PCI were enrolled in this study. Admission PLR levels were measured before PCI. Serum creatinine values were measured before and within 72 h after the administration of contrast agents. Patients were divided into 2 groups: the CIN group and the no-CIN group. CIN was defined as an increase in serum creatinine level of ≥0.5 mg/dl or 25% above baseline within 72 h after contrast administration.
  
  
  RESULTS
  CIN developed in 53 patients (15.9%). Baseline PLR was significantly higher in patients who developed CIN compared to those who did not (160.8 ± 29.7 and 135.1 ± 26.1, respectively; p < 0.001). Multivariate analyses found that PLR [odds ratio (OR) 3.453, 95% confidence interval (CI) 1.453-8.543; p = 0.004] and admission creatinine (OR 6.511, 95% CI 1.759-11.095; p = 0.002) were independent predictors of CIN.
  
  
  CONCLUSIONS
  The admission PLR level is an independent predictor of the development of CIN after PCI in ACS.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Muhammed Bora
authors.initials: MB
authors.lastname: Demircelik
authors.affiliation: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Alparslan
authors.initials: A
authors.lastname: Kurtul
authors.affiliation: Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Ocek
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Cakmak
authors.affiliation: Department of Cardiology, Antalya Education and Research Hospital, Antalya, Turkey.
authors.forename: Cagın
authors.initials: C
authors.lastname: Ureyen
authors.affiliation: Department of Cardiology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey.
authors.forename: Beyhan
authors.initials: B
authors.lastname: Eryonucu
keywords: Acute coronary syndrome; Contrast-induced nephropathy; Hematological parameters; Platelet-to-lymphocyte ratio