title: Autoimmune myelofibrosis and systemic lupus erythematosus in a middle-aged male presenting only with severe anemia: a case report.
abstract: Autoimmune myelofibrosis is a distinct clinicopathologic entity that occasionally occurs with autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. Most cases of autoimmune myelofibrosis have been reported in female patients with a known history of SLE. We report a case of a middle-aged male patient with an unusual presentation of SLE and autoimmune myelofibrosis who presented only with severe anemia initially and was later diagnosed with SLE and autoimmune myelofibrosis. The patient's condition improved dramatically after treatment with corticosteroids.SLE and autoimmune myelofibrosis is a rare but potentially devastating condition. Anemia maybe the only presenting symptom in addition to bone marrow fibrosis and careful clinical and laboratory assessment is imperative. Corticosteroids maybe useful and spare patients from bone marrow transplantation.
authors.affiliation: From the Section of Rheumatology, Department of General Internal Medicine (XP,HL); Department of Hematopathology, Division of Pathology/Lab Medicine (SK) and Section of Benign Hematology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (THO).
authors.forename: Xerxes
authors.initials: X
authors.lastname: Pundole
authors.forename: Sergej
authors.initials: S
authors.lastname: Konoplev
authors.forename: Thein Hlaing
authors.initials: TH
authors.lastname: Oo
authors.forename: Huifang
authors.initials: H
authors.lastname: Lu
mesh_terms: D000328:Adult; D000740:Anemia / Q000175:diagnosis*; D001327:Autoimmune Diseases; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D006403:Hematologic Tests; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis*; D008297:Male; D055728:Primary Myelofibrosis / Q000175:diagnosis*