title: Atlas of tissue renin-angiotensin-aldosterone system in human: A transcriptomic meta-analysis.
abstract: Tissue renin-angiotensin-aldosterone system (RAAS) has attracted much attention because of its physiological and pharmacological implications; however, a clear definition of tissue RAAS is still missing. We aimed to establish a preliminary atlas for the organization of RAAS across 23 different normal human tissues. A set of 37 genes encoding classical and novel RAAS participants including gluco- and mineralo-corticoids were defined as extended RAAS (extRAAS) system. Microarray data sets containing more than 10 normal tissues were downloaded from the GEO database. R software was used to extract expression levels and construct dendrograms of extRAAS genes within each data set. Tissue co-expression modules were then extracted from reproducible gene clusters across data sets. An atlas of the maps of tissue-specific organization of extRAAS was constructed from gene expression and coordination data. Our analysis included 143 data sets containing 4933 samples representing 23 different tissues. Expression data provided an insight on the favored pathways in a given tissue. Gene coordination indicated the existence of tissue-specific modules organized or not around conserved core groups of transcripts. The atlas of tissue-specific organization of extRAAS will help better understand tissue-specific effects of RAAS. This will provide a frame for developing more effective and selective pharmaceuticals targeting extRAAS.
authors.affiliation: 1] EA4173, Functional genomics of arterial hypertension, Hôpital Nord-Ouest, Villefranche-sur-Saône; Université Lyon1, Lyon, France [2] ER045, Laboratory of stem cells, Department of Biology, Faculty of sciences, Lebanese University, Beirut, Lebanon.
authors.forename: Ali
authors.initials: A
authors.lastname: Nehme
authors.affiliation: EA4173, Functional genomics of arterial hypertension, Hôpital Nord-Ouest, Villefranche-sur-Saône; Université Lyon1, Lyon, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Cerutti
authors.affiliation: EA4173, Functional genomics of arterial hypertension, Hôpital Nord-Ouest, Villefranche-sur-Saône; Université Lyon1, Lyon, France.
authors.forename: Nedra
authors.initials: N
authors.lastname: Dhaouadi
authors.affiliation: EA4173, Functional genomics of arterial hypertension, Hôpital Nord-Ouest, Villefranche-sur-Saône; Université Lyon1, Lyon, France.
authors.forename: Marie Paule
authors.initials: MP
authors.lastname: Gustin
authors.affiliation: EA4173, Functional genomics of arterial hypertension, Hôpital Nord-Ouest, Villefranche-sur-Saône; Université Lyon1, Lyon, France.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Courand
authors.affiliation: ER045, Laboratory of stem cells, Department of Biology, Faculty of sciences, Lebanese University, Beirut, Lebanon.
authors.forename: Kazem
authors.initials: K
authors.lastname: Zibara
authors.affiliation: EA4173, Functional genomics of arterial hypertension, Hôpital Nord-Ouest, Villefranche-sur-Saône; Université Lyon1, Lyon, France.
authors.forename: Giampiero
authors.initials: G
authors.lastname: Bricca
mesh_terms: D000450:Aldosterone / Q000737:chemistry / Q000378:metabolism*; D016000:Cluster Analysis; D016208:Databases, Factual; D015870:Gene Expression; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000473:pathology; D005810:Multigene Family; D020411:Oligonucleotide Array Sequence Analysis; D012084:Renin-Angiotensin System / Q000235:genetics*; D012984:Software; D059467:Transcriptome
chemical_list: D000450:Aldosterone