title: Bone morphological analyses in Spontaneously Diabetic Torii (SDT) fatty rats.
abstract: The Spontaneously Diabetic Torii (SDT) fatty rat, a model for obese type 2 diabetes, shows bone quantitative abnormalities, namely low bone mineral density (BMD). The objective of this study was to evaluate bone morphological changes, in particular identifying the bone qualitative abnormalities, in the SDT fatty rat. Male SDT fatty rats showed increases in total trabecular area and trabecular number and decreases in trabecular thickness in cancellous bones of the proximal tibia, indicating trabecular miniaturization. The SDT fatty rat is useful for investigation of pathophysiological changes in bone quality in diabetic osteoporosis.
authors.affiliation: Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohta
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kimura
authors.forename: Masaya
authors.initials: M
authors.lastname: Hirata
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamada
authors.forename: Toshie
authors.initials: T
authors.lastname: Sugiyama
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000502:physiology*; D003920:Diabetes Mellitus; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose