title: Use of a Microsoft Excel based add-in program to calculate plasma sinistrin clearance by a two-compartment model analysis in dogs.
abstract: Assessment of renal function by means of plasma clearance of a suitable marker has become standard procedure for estimation of glomerular filtration rate (GFR). Sinistrin, a polyfructan solely cleared by the kidney, is often used for this purpose. Pharmacokinetic modeling using adequate software is necessary to calculate disappearance rate and half-life of sinistrin. The purpose of this study was to describe the use of a Microsoft excel based add-in program to calculate plasma sinistrin clearance, as well as additional pharmacokinetic parameters such as transfer rates (k), half-life (t1/2) and volume of distribution (Vss) for sinistrin in dogs with varying degrees of renal function.
authors.affiliation: Small Animal Clinic (Internal Medicine), Justus - Liebig - University, Frankfurter Strasse 126, 35392 Giessen, Germany. Electronic address: sarah.steinbach@vetmed.uni-giessen.de.
authors.forename: Sarah M L
authors.initials: SM
authors.lastname: Steinbach
authors.affiliation: Vet Freedom Ltd, Brockenhurst, Hampshire, UK.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Sturgess
authors.affiliation: School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire, UK.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Dunning
authors.affiliation: Small Animal Clinic (Internal Medicine), Justus - Liebig - University, Frankfurter Strasse 126, 35392 Giessen, Germany.
authors.forename: Reto
authors.initials: R
authors.lastname: Neiger
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000662:veterinary*; D006207:Half-Life; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests / Q000662:veterinary*; D009844:Oligosaccharides / Q000097:blood* / Q000493:pharmacokinetics*; D012984:Software
chemical_list: D015415:Biomarkers; D009844:Oligosaccharides; C064636:sinistrin
keywords: Glomerular filtration rate; Inulin, sinistrin; Pharmacokinetic; Renal function; Small animals