title: Cohesion and the aneuploid phenotype in Alzheimer's disease: A tale of genome instability.
abstract: Neurons are postmitotic cells that are in permanent cell cycle arrest. However, components of the cell cycle machinery that are expressed in Alzheimer's disease (AD) neurons are showing features of a cycling cell and those attributed to a postmitotic cell as well. Furthermore, the unique physiological operations taking place in neurons, ascribed to "core cell cycle regulators" are also key regulators in cell division. Functions of these cell cycle regulators include neuronal migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation and plasticity. In this review, we focus on cohesion and cohesion related proteins in reference to their neuronal functions and how impaired centromere/cohesion dynamics may connect cell cycle dysfunction to aneuploidy in AD.
authors.affiliation: Institute for Nuclear Research "Vinca", Laboratory for Radiobiology and Molecular Genetics, University of Belgrade, P.O. 522, 11001 Belgrade, Serbia. Electronic address: vladanbajic@yahoo.com.
authors.forename: Vladan
authors.initials: V
authors.lastname: Bajic
authors.affiliation: Faculty of Pharmacy, Institute of Physiology, Department of Biology and Human Genetics, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia. Electronic address: bilja22@pharmacy.bg.ac.rs.
authors.forename: Biljana
authors.initials: B
authors.lastname: Spremo-Potparevic
authors.affiliation: Faculty of Pharmacy, Institute of Physiology, Department of Biology and Human Genetics, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia. Electronic address: lada@pharmacy.bg.ac.rs.
authors.forename: Lada
authors.initials: L
authors.lastname: Zivkovic
authors.affiliation: Institute for Nuclear Research "Vinca", Laboratory for Radiobiology and Molecular Genetics, University of Belgrade, P.O. 522, 11001 Belgrade, Serbia. Electronic address: isenovic@yahoo.com.
authors.forename: Esma R
authors.initials: ER
authors.lastname: Isenovic
authors.affiliation: Paul-Flechsig-Institute for Brain Research, University of Leipzig, School of Medicine, Leipzig, Germany. Electronic address: aret@medizin.uni-leipzig.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Arendt
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D000782:Aneuploidy; D001921:Brain / Q000378:metabolism; D002453:Cell Cycle / Q000235:genetics; D018797:Cell Cycle Proteins / Q000235:genetics*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D005260:Female; D042822:Genomic Instability; D006801:Humans; D008297:Male; D009474:Neurons / Q000378:metabolism; D010641:Phenotype; D000097722:Cohesins
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D000097722:Cohesins
keywords: Alzheimer's disease (AD); Aneuploidy; Cell cycle; Cohesion; Genomic mosaicism