title: Vaccine technologies against avian influenza: current approaches and new directions.
abstract: The potential epidemiological human pandemic resulting from highly pathogenic avian influenza (HPAI) H5N1 has been studied extensively since the identification of the virus in the Guangdong province of China. The majority of research has focused on the unique and severe histopathological lesions induced by the virus. The severe pathological presentation of these infections has also prompted interest in identifying preventive and therapeutic approaches against HPAI. The potential severity of a HPAI pandemic and the efforts to identify effective intervention strategies have led to many novel discoveries in vaccine and antiviral development that are critically examined in this review.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Ross
authors.forename: Lucas M
authors.initials: LM
authors.lastname: Huntimer
authors.forename: Julia E
authors.initials: JE
authors.lastname: Vela Ramirez
authors.forename: Justin R
authors.initials: JR
authors.lastname: Adams
authors.forename: Susan L
authors.initials: SL
authors.lastname: Carpenter
authors.forename: Marian L
authors.initials: ML
authors.lastname: Kohut
authors.forename: Tatiana
authors.initials: T
authors.lastname: Bronich
authors.forename: Richard
authors.initials: R
authors.lastname: Webby
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Legge
authors.forename: Surya K
authors.initials: SK
authors.lastname: Mallapragadal
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Wannemuehler
authors.forename: Balaji
authors.initials: B
authors.lastname: Narasimhan
mesh_terms: D000818:Animals; D001717:Birds / Q000276:immunology / Q000821:virology; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000502:physiology; D007252:Influenza Vaccines / Q000276:immunology*; D005585:Influenza in Birds / Q000276:immunology* / Q000473:pathology / Q000821:virology; D007251:Influenza, Human / Q000276:immunology / Q000821:virology; D014611:Vaccination / Q000379:methods* / Q000639:trends*
chemical_list: D007252:Influenza Vaccines