title: Renalase: Another puzzle piece between hypertension and simple renal cysts?
abstract: OBJECTIVE
  Since renalase is mostly expressed in kidney tubules, simple renal cyst (SRC) originates from the kidney tubules, and both conditions are related to hypertension, it may be possible that SRC is associated with increased renalase levels. Therefore, in the current study we aimed to confirm the relation between renalase and epinephrine levels, the association between SRC and renalase levels and the association between renalase, blood pressure levels and endothelial dysfunction.
  
  
  METHODS
  We made a cross-sectional study including 75 patients with SRC, and 51 controls were included to the study. Flow-mediated dilatation (FMD) was assessed, and serum renalase and epinephrine levels were determined.
  
  
  RESULTS
  Patient with SRC had lower renalase, higher epinephrine and lower FMD levels when compared to patients without SRC (p < 0.05). Log renalase was correlated with log epinephrine (r = -0.302, p = 0.001) and log FMD (r = 0.642, p < 0.0001). There was no correlation between renalase and urine albumin/creatinine ratio and glomerular filtration rate. In univariate analysis, age, glomerular filtration rate, renalase and FMD were associated with the presence of SRC. Multivariate regression analysis of factors which are statistically significant in univariate analysis showed that age and renalase was associated with the presence of SRC.
  
  
  CONCLUSIONS
  We have demonstrated that renalase levels were associated with the presence of SRC and endothelial dysfunction. Further research is necessary to highlight underlying mechanisms.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
authors.forename: Omer Celal
authors.initials: OC
authors.lastname: Elcioglu
authors.forename: Baris
authors.initials: B
authors.lastname: Afsar
authors.forename: Mumtaz
authors.initials: M
authors.lastname: Takir
authors.forename: Aybala Erek
authors.initials: AE
authors.lastname: Toprak
authors.forename: Ali
authors.initials: A
authors.lastname: Bakan
authors.forename: Sibel
authors.initials: S
authors.lastname: Bakan
authors.forename: Osman
authors.initials: O
authors.lastname: Kostek
authors.forename: Alihan
authors.initials: A
authors.lastname: Oral
authors.forename: Hayriye
authors.initials: H
authors.lastname: Erman
authors.forename: Adrian
authors.initials: A
authors.lastname: Covic
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kanbay
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D004837:Epinephrine / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D052177:Kidney Diseases, Cystic / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D007677:Kidney Function Tests / Q000379:methods; D007684:Kidney Tubules / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D013223:Statistics as Topic; D014463:Ultrasonography; D014664:Vasodilation / Q000502:physiology*
chemical_list: D003404:Creatinine; D008995:Monoamine Oxidase; C521557:renalase; D004837:Epinephrine