title: Sex differences in autism spectrum disorders: does sex moderate the pathway from clinical symptoms to adaptive behavior?
abstract: We explored sex differences in diagnostic categories, clinical symptoms and adaptive behavior of persons with autism spectrum disorders, as well as sex-specific correlations of clinical and adaptive caracteristics. The study involved 108 patients (83 males, 6.73 ± 4.33 years old) diagnosed with autism spectrum disorders (ASD). Assessment included ADI-R and Vineland Adaptive Behavior Scale II. Males were more often diagnosed with typical autism. There were no sex differences in the autistic symptoms, while females showed better functioning in Daily living skills, without reaching statistically significant difference (p = 0.062). We have found different associations of autistic symptoms with different aspects of adaptive behavior in males and females. Social reciprocity in females correlated with social domain of adaptive behavior, in a positive direction. Our findings have shown that although there are no sex differences in autistic symptoms, females tend to be somewhat more functional, and are also less frequently diagnosed with typical autism. Our results have also shown that sex might moderate the way clinical symptoms are expressed in adaptive behavior. Social reciprocity might be the core feature regarding sex differences in ASD. Our findings might have diagnostic and therapeutical implications, pointing out to the need for individualized, sex-specific treatment in this group of disorders.
authors.affiliation: Institute of Mental Health, Palmoticeva 37, Belgrade, Serbia.
authors.forename: Vanja
authors.initials: V
authors.lastname: Mandic-Maravic
authors.affiliation: Institute of Mental Health, Palmoticeva 37, Belgrade, Serbia.|School of Medicine, University of Belgrade, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Pejovic-Milovancevic
authors.affiliation: Institute of Mental Health, Palmoticeva 37, Belgrade, Serbia.|School of Medicine, University of Belgrade, Serbia.
authors.forename: Marija
authors.initials: M
authors.lastname: Mitkovic-Voncina
authors.affiliation: Institute of Mental Health, Palmoticeva 37, Belgrade, Serbia.
authors.forename: Milutin
authors.initials: M
authors.lastname: Kostic
authors.affiliation: Institute of Mental Health, Palmoticeva 37, Belgrade, Serbia.
authors.forename: Olivera
authors.initials: O
authors.lastname: Aleksic-Hil
authors.affiliation: Institute of Mental Health, Palmoticeva 37, Belgrade, Serbia.|Faculty of Media and Communication, University of Singidunum, Belgrade, Serbia.
authors.forename: Jelena
authors.initials: J
authors.lastname: Radosavljev-Kircanski
authors.affiliation: Institute of Mental Health, Palmoticeva 37, Belgrade, Serbia.
authors.forename: Teodora
authors.initials: T
authors.lastname: Mincic
authors.affiliation: Institute of Mental Health, Palmoticeva 37, Belgrade, Serbia.|School of Medicine, University of Belgrade, Serbia.|Serbian Academy of Sciences and Arts, Belgrade, Serbia.
authors.forename: Dusica
authors.initials: D
authors.lastname: Lecic-Tosevski
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000223:Adaptation, Psychological; D000067877:Autism Spectrum Disorder / Q000175:diagnosis* / Q000523:psychology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D012737:Sex Factors; D012919:Social Behavior