title: Neurological Symptoms of Sarcoidosis-induced Small Fiber Neuropathy Effectively Relieved with High-dose Steroid Pulse Therapy.
abstract: A 59-year-old woman was admitted to our hospital for an evaluation of a 10-day history of progressive pain and hypoesthesia of the right lower back associated with fever and constipation. Sarcoidosis was confirmed on mediastinal lymph node and skin biopsies. Although the neurological symptoms were suspected due to sarcoidosis-induced nerve dysfunction, nerve conduction studies and other routine examinations did not show any abnormalities. The intraepidermal nerve fiber density assessed on a skin biopsy was significantly reduced, suggesting small-fiber neuropathy (SFN). The patient was finally diagnosed with sarcoidosis-induced SFN, and her neurological symptoms were effectively relieved with high-dose steroid therapy.
authors.affiliation: Department of Respiratory Medicine, Tsuchiura Kyodo General Hospital, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Saito
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Yuta
authors.initials: Y
authors.lastname: Adachi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Yamashita
authors.forename: Yoko
authors.initials: Y
authors.lastname: Wakai
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Saito
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Keiko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Soroku
authors.initials: S
authors.lastname: Yagihashi
authors.forename: Jiro
authors.initials: J
authors.lastname: Terada
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi
mesh_terms: D001706:Biopsy; D004916:Erythromelalgia / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009460:Neurologic Examination; D012507:Sarcoidosis / Q000150:complications*; D012867:Skin / Q000473:pathology
chemical_list: D005938:Glucocorticoids