title: DSigDB: drug signatures database for gene set analysis.
abstract: We report the creation of Drug Signatures Database (DSigDB), a new gene set resource that relates drugs/compounds and their target genes, for gene set enrichment analysis (GSEA). DSigDB currently holds 22 527 gene sets, consists of 17 389 unique compounds covering 19 531 genes. We also developed an online DSigDB resource that allows users to search, view and download drugs/compounds and gene sets. DSigDB gene sets provide seamless integration to GSEA software for linking gene expressions with drugs/compounds for drug repurposing and translational research.
  
  
  METHODS
  DSigDB is freely available for non-commercial use at http://tanlab.ucdenver.edu/DSigDB.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
  
  
  BACKGROUND
  aikchoon.tan@ucdenver.edu.
authors.affiliation: Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.
authors.forename: Minjae
authors.initials: M
authors.lastname: Yoo
authors.affiliation: Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.
authors.forename: Jimin
authors.initials: J
authors.lastname: Shin
authors.affiliation: Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.
authors.forename: Jihye
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.
authors.forename: Karen A
authors.initials: KA
authors.lastname: Ryall
authors.affiliation: Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.
authors.forename: Kyubum
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.
authors.forename: Sunwon
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.
authors.forename: Minji
authors.initials: M
authors.lastname: Jeon
authors.affiliation: Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.
authors.forename: Jaewoo
authors.initials: J
authors.lastname: Kang
authors.affiliation: Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea Department of Medicine, Translational Bioinformatics and Cancer Systems Biology Laboratory, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA and Department of Computer Science and Engineering, Korea University, Seoul 136-713, South Korea.
authors.forename: Aik Choon
authors.initials: AC
authors.lastname: Tan
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics; D019295:Computational Biology / Q000379:methods*; D062313:Databases, Pharmaceutical; D058492:Drug Repositioning; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D012984:Software
chemical_list: D047428:Protein Kinase Inhibitors; C512478:EGFR protein, human; D066246:ErbB Receptors