title: [Diagnostic value of liver stiffness measurement combined with serum high-sensitivity C-reactive protein detection in HBV-related cirrhosis patients complicated with primary liver cancer].
abstract: OBJECTIVE
  The aim of this study was to explore the diagnostic value of liver stiffness measurement combined with serum high-sensitivity C-reactive protein detection in HBV-related cirrhosis patients complicated with primary liver cancer.
  
  
  METHODS
  A total of 156 previously untreated chronic hepatitis B-related cirrhosis patients and 50 healthy subjects were included in this study. The 156 patients were divided into two groups: those with primary liver cancer (67 cases) and without liver cancer (89 cases). The 50 healthy subjects were considered as normal control group. Liver stiffness measurement (LSM) was conducted and serum high-sensitivity C-reactive protein (CRP) level was assayed in all the 156 patients and 50 normal individuals, and their measurement values were statistically compared and analyzed.
  
  
  RESULTS
  The LSM value was (39.72±29.05) kPa in the liver cancer patients, significantly higher than the (27.81±18.46) kPa in the cirrhosis alone patients and (4.25±0.74) kPa in the healthy controls (P<0.01 for both). Serum hs-CRP levels in the liver cancer patients was 5.81mg/L, significantly higher than 1.78 mg/L in the cirrhosis alone patients and 0.38mg/L in healthy controls, (P<0.01 for both). The higher the grade of LSM values was, the positive rate of CRP was higher in the cirrhosis patients complicated with primary liver cancer. In patients with LSM values ≥27.6 kPa, the serum CRP positive rate was 64.2% in patients with primary liver cancer, significantly higher than the 38.0% in patients with cirrhosis alone (P<0.01). In the 67 HBV-related cirrhosis patients complicated primary liver cancer, the LSM value and serum hs-CRP level in AFP-positive patients were (48.95±28.59) kPa and 4.91 mg/L, respectively, higher than those in the AFP-negative patients (28.64±26.83) kPa and 4.16 mg/L, but with a non-significant difference (P>0.05).
  
  
  CONCLUSIONS
  Liver stiffness measurement combined with serum high-sensitivity C-reactive protein detection may have potential diagnostic implications as a marker of primary liver cancer occurrence in patients with HBV-related cirrhosis.
authors.affiliation: Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Luo
authors.affiliation: Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
authors.forename: Shuaiwei
authors.initials: S
authors.lastname: Liu
authors.affiliation: Department of Infectious Disease, General Hospital of Ningxia Medical University, Yinchuan 750004, China; Email: 13619511768 @163.com.
authors.forename: Xiangchun
authors.initials: X
authors.lastname: Ding
mesh_terms: D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D054459:Elasticity Imaging Techniques; D005355:Fibrosis; D019694:Hepatitis B, Chronic / Q000150:complications / Q000378:metabolism*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology / Q000378:metabolism* / Q000821:virology; D008113:Liver Neoplasms
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein