title: Differences in 24-h blood pressure profile of Japanese hypertensive patients under ARB treatment.
abstract: Blood pressure (BP) control throughout the entire day is recommended for cardiovascular protection. Angiotensin-II receptor blockers (ARBs) are widely used in hypertensive patients because of beneficial class effects. It is uncertain, however, whether are there any differences in 24-h BP profiles among ARBs. We examined ambulatory blood pressure monitoring (ABPM) among 211 Japanese hypertensive patients (age, 69.4 ± 9.6 years; female, 59.2%) under treatment with five different ARBs. Patients were divided into five groups according to ARBs prescribed. Patient backgrounds were almost identical in all the groups and there were no differences in office, 24-h and daytime BP; however, nighttime BP with olmesartan was significantly lower than with other ARBs. Office BPs with candesartan and telmisartan, but not other ARBs, correlated well with 24-h BP (p < 0.01). Also, there were higher correlations between daytime and nighttime BP with candesartan and telmisartan. In all patients, pulse pressure with office BP was significantly correlated with ambulatory arterial stiffness index (p = 0.001) and fluctuation of systolic BP on ABPM (p = 0.002). In conclusion, different ARB treatments produced meaningful differences in 24-h profiles.
authors.affiliation: a Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine , University of Miyazaki , Miyazaki , Japan .
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kita
authors.affiliation: b Health Administration Center, University of the Ryukyus , Okinawa , Japan .|c Department of Cardiovascular Medicine , Nephrology, and Neurology, University of the Ryukyus Graduate School of Medicine , Okinawa , Japan .
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sakima
authors.affiliation: d Yokota Naika , Miyazaki , Japan .
authors.forename: Naoto
authors.initials: N
authors.lastname: Yokota
authors.affiliation: e Tamaki Clinic , Miyazaki , Japan .
authors.forename: Noboru
authors.initials: N
authors.lastname: Tamaki
authors.affiliation: f Etoh Clinic , Miyazaki , Japan .
authors.forename: Takuma
authors.initials: T
authors.lastname: Etoh
authors.affiliation: g Nozaki Higashi Hospital , Miyazaki , Japan .
authors.forename: Toru
authors.initials: T
authors.lastname: Shimokubo
authors.affiliation: h Keiaikai Chibana Clinic , Okinawa , Japan , and.
authors.forename: Seigo
authors.initials: S
authors.lastname: Nakada
authors.affiliation: i Okinawa College of Rehabilitation and Welfare , Okinawa , Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Takishita
authors.affiliation: b Health Administration Center, University of the Ryukyus , Okinawa , Japan .
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohya
authors.affiliation: a Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine , University of Miyazaki , Miyazaki , Japan .
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitamura
mesh_terms: D000368:Aged; D057911:Angiotensin Receptor Antagonists / Q000008:administration & dosage / Q000493:pharmacokinetics; D001562:Benzimidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics; D001713:Biphenyl Compounds; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D007093:Imidazoles / Q000008:administration & dosage / Q000493:pharmacokinetics; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D013777:Tetrazoles / Q000008:administration & dosage / Q000493:pharmacokinetics; D013810:Therapeutic Equivalency
chemical_list: D057911:Angiotensin Receptor Antagonists; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D007093:Imidazoles; D013777:Tetrazoles; C437965:olmesartan; C081643:candesartan
keywords: Angiotensin-II receptor blocker; Japanese; ambulatory blood pressure monitoring; hypertension; pulse pressure