title: Phenylpropanoids and neolignans from Smilax trinervula.
abstract: A new phenylpropanoid glucoside and two new neolignans, namely (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-3-(β-d-glucopyranosyloxy)-1, 2, 3-propanetriol (1), and (7R, 8R)-4, 7, 9, 9'-tetrahydroxy-3, 5, 3', 5'-tetramethoxy-8-4'-oxyneolignan 4-O-β-d-glucopyranoside (2) and 3', 9, 9'-trihydroxy-3, 5-dimethoxy-8-O-4'-neolignan-4-O-β-d-glucopyranoside (3), together with a new natural product (1S, 2R)-1-(3, 4, 5-trimethoxyphenyl)-1, 2, 3-propanetriol (4) and four known compounds (5-8) were isolated from the rhizomes of Smilax trinervula. Their structures were established mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds 1-8 were tested in vitro for their cytotoxic activities against 5 human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo and Vero). Compounds 7 and 8 exhibited cytotoxic activity against Lovo, with IC50 values of 18.7μM and 16.8μM, respectively.
authors.affiliation: Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China.
authors.forename: Jicheng
authors.initials: J
authors.lastname: Shu
authors.affiliation: Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liang
authors.affiliation: Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liang
authors.affiliation: Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liang
authors.affiliation: Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China.
authors.forename: Fengqin
authors.initials: F
authors.lastname: Li
authors.affiliation: Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shao
authors.affiliation: Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China.
authors.forename: Ronghua
authors.initials: R
authors.lastname: Liu
authors.affiliation: Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang 330004, China. Electronic address: huilianh@163.com.
authors.forename: Huilian
authors.initials: H
authors.lastname: Huang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor / Q000187:drug effects; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry*; D032281:Smilax / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D017705:Lignans; D010936:Plant Extracts
keywords: Cytotoxic activity; Neolignans; Phenylpropanoids; Smilax trinervula