title: Microencapsulation of probiotic bacteria using thermo-sensitive sol-gel polymers for powdered infant formula.
abstract: In this study the application of thermo-sensitive sol-gel polymers in microencapsulation formulation of probiotic bacteria, Bifidobacterium animalis spp lactis, for powdered infant formula (PIF), which is reconstituted at 70 °C, has been assessed. A double-layered microcapsule containing hydroxypropyl methyl cellulose (HPMC) as an inner layer and an outer layer, as the smart coating layer, based on a combination of hydroxypropyl cellulose (HPC) and poloxamer was designed. Generally, this specific microencapsulation provided superior protection against the reconstitution temperature. A high molecular weight of HPC and a greater thickness of the smart coating layer resulted in a delayed release of the bacteria from the microcapsules especially in the PIF composition. However, this was compensated by a high stability of the bacteria at 70 °C. Both the surface texture and particle size distribution of microcapsules have been respectively characterised by scanning electron microscopy and particle size analysis.
authors.affiliation: Department of Pharmaceutical Engineering, Azrieli - College of Engineering , Jerusalem , Israel and.
authors.forename: Adel
authors.initials: A
authors.lastname: Penhasi
mesh_terms: D001644:Bifidobacterium / Q000166:cytology*; D002214:Capsules / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004339:Drug Compounding; D006801:Humans; D065347:Hypromellose Derivatives / Q000737:chemistry*; D007223:Infant; D041943:Infant Formula / Q000382:microbiology*; D044367:Phase Transition; D020442:Poloxamer / Q000737:chemistry*; D019936:Probiotics / Q000008:administration & dosage*; D013696:Temperature
chemical_list: D002214:Capsules; D020442:Poloxamer; D065347:Hypromellose Derivatives; D002482:Cellulose; C008079:hydroxypropylcellulose
keywords: Bifidobacterium animalis spp lactis; hydroxypropyl cellulose; hydroxypropylmethyl cellulose; lower critical solution temperature; poloxamer; smart polymer