title: Wnt signaling in dendritic cells: its role in regulation of immunity and tolerance.
abstract: A fundamental puzzle in immunology is how the immune system launches robust immunity against pathogens while maintaining a state of tolerance to the body's own tissues and the trillions of commensal microorganisms and food antigens that confront them every day. Innate immune cells, such as dendritic cells (DCs) and macrophages, play a fundamental role in this process. Emerging studies have highlighted that the Wnt signaling pathway, particularly in DCs, plays a major role in regulating tolerance versus immunity. Here, we review our current understanding of how Wnt-signaling shapes the immune response and, in addition, highlight unanswered questions, the solution of which will be imperative in the rational exploitation of this pathway in vaccine design and immune therapy.
authors.affiliation: Cancer Immunology, Inflammation, and Tolerance Program, GRU Cancer Center, Georgia Regents University, Augusta, GA 30912, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Swafford
authors.forename: Santhakumar
authors.initials: S
authors.lastname: Manicassamy
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology*; D006801:Humans; D007107:Immune System; D007108:Immune Tolerance; D007167:Immunotherapy / Q000379:methods; D007249:Inflammation / Q000276:immunology; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D008024:Ligands; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology; D014612:Vaccines / Q000627:therapeutic use; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D051176:beta Catenin
chemical_list: D008024:Ligands; D014612:Vaccines; D051153:Wnt Proteins; D051176:beta Catenin