title: Donor Nucleotide-Binding Oligomerization-Containing Protein 2 (NOD2) Single Nucleotide Polymorphism 13 Is Associated with Septic Shock after Allogeneic Stem Cell Transplantation.
abstract: Single nucleotide polymorphisms (SNPs) within nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and toll-like receptor (TLR) 5 genes have been recently associated with the incidence and outcome of infections. In this study, we analyzed 38 patients with septic shock after allogeneic stem cell transplantation (allo-SCT) for an association of SNPs within NOD2 and TLR5 genes, with susceptibility to septic shock. One hundred twenty-seven transplant recipients unaffected by any infectious complications were used as controls. We found a significant association between the presence of donor NOD2 SNP13 (3016_3017insC) and the incidence of septic shock (P = .002). In multivariate analysis, donor NOD2 SNP13 appeared as an independent risk factor for the incidence of septic shock after allo-SCT. No association was found for recipient SNPs (NOD2 and TLR5) and donor NOD2 SNP8, SNP12, and TLR5-Stop SNP. Our results suggest that NOD2 SNP13 has an impact on the pathophysiology of severe infectious complications and is an independent risk factor for the development of septic shock after allo-SCT.
authors.affiliation: Department of Internal Medicine III, Hematology and Oncology, University Hospital, Regensburg, Germany. Electronic address: matthias.grube@klinik.uni-regensburg.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Grube
authors.affiliation: Leibniz-Institute for Farm Animal Biology, Institute of Genome Biology, Cell Signaling Unit, Dummerstorf, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Brenmoehl
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Rogler
authors.affiliation: Department of Internal Medicine III, Hematology and Oncology, University Hospital, Regensburg, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Hahn
authors.affiliation: Department of Internal Medicine III, Hematology and Oncology, University Hospital, Regensburg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Herr
authors.affiliation: Department of Internal Medicine III, Hematology and Oncology, University Hospital, Regensburg, Germany.
authors.forename: Ernst
authors.initials: E
authors.lastname: Holler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012772:Shock, Septic / Q000235:genetics* / Q000378:metabolism*; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein
keywords: Nucleotide-binding oligomerization domain; Sepsis; Single nucleotide polymorphisms; Stem cell transplantation