title: miRNA expression atlas in male rat.
abstract: MicroRNAs (miRNAs) are small (~22 nucleotide) noncoding RNAs that play pivotal roles in regulation of gene expression. The value of miRNAs as circulating biomarkers is now broadly recognized; such tissue-specific biomarkers can be used to monitor tissue injury and several pathophysiological conditions in organs. In addition, miRNA profiles of normal organs and tissues are important for obtaining a better understanding of the source of modulated miRNAs in blood and how those modulations reflect various physiological and toxicological conditions. This work was aimed at creating an miRNA atlas in rats, as part of a collaborative effort with the Toxicogenomics Informatics Project in Japan (TGP2). We analyzed genome-wide miRNA profiles of 55 different organs and tissues obtained from normal male rats using miRNA arrays. The work presented herein represents a comprehensive dataset derived from normal samples profiled in a single study. Here we present the whole dataset with miRNA profiles of multiple organs, as well as precise information on experimental procedures and organ-specific miRNAs identified in this dataset.
authors.affiliation: Exploratory Research Laboratories, Tsukuba Research Institute, Ono Pharmaceutical Co., Ltd. , 17-2 Wadai, Tsukuba-shi, Ibaraki 300-4247, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Minami
authors.affiliation: Drug Developmental Research Laboratories, Shionogi & Co., Ltd. , 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan ; Toxicogenomics Informatics Project, National Institute of Biomedical Innovation , 7-6-8 Asagi, Ibaraki, Osaka 567-0085, Japan.
authors.forename: Takeki
authors.initials: T
authors.lastname: Uehara
authors.affiliation: Drug Developmental Research Laboratories, Shionogi & Co., Ltd. , 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan ; Toxicogenomics Informatics Project, National Institute of Biomedical Innovation , 7-6-8 Asagi, Ibaraki, Osaka 567-0085, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Morikawa
authors.affiliation: Drug Safety Research Laboratories, Astellas Pharma Inc. , 2-1-6, Kashima, Yodogawa-ku, Osaka 532-8514, Japan.
authors.forename: Ko
authors.initials: K
authors.lastname: Omura
authors.affiliation: Drug Safety Research Laboratories, Astellas Pharma Inc. , 2-1-6, Kashima, Yodogawa-ku, Osaka 532-8514, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kanki
authors.affiliation: Chemistry, Manufacturing and Controls Center, Takeda Pharmaceutical Company Limited , 17-85, Jusohonmachi 2-chome, Yodogawaku, Osaka 532-8686, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Horinouchi
authors.affiliation: Toxicogenomics Informatics Project, National Institute of Biomedical Innovation , 7-6-8 Asagi, Ibaraki, Osaka 567-0085, Japan ; National Institute of Health Sciences , 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ono
authors.affiliation: Toxicogenomics Informatics Project, National Institute of Biomedical Innovation , 7-6-8 Asagi, Ibaraki, Osaka 567-0085, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamada
authors.affiliation: National Institute of Health Sciences , 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohno
authors.affiliation: Toxicogenomics Informatics Project, National Institute of Biomedical Innovation , 7-6-8 Asagi, Ibaraki, Osaka 567-0085, Japan ; Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo , Kyotanabe, Kyoto 610-0395, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Urushidani
mesh_terms: D000818:Animals; D015870:Gene Expression; D020869:Gene Expression Profiling; D016678:Genome; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D009928:Organ Specificity; D051381:Rats
chemical_list: D035683:MicroRNAs