title: A novel antimicrobial flavonoid from the stem bark of Commiphora pedunculata (Kotschy & Peyr.) Engl.
abstract: A new flavonoid, 2-(3,5-dihydroxy-4-methoxy-phenyl)-3,5-dihydroxy-8,8-dimethyl-2,3-dihydro-8H-pyrano[3,2]chromen-4-one, together with previously reported epicatechin was isolated from the ethyl acetate soluble fraction of the methanol extract of the stem bark of Commiphora pedunculata. The structures of these compounds were elucidated based on extensive analysis of their spectral data, including 1 and 2D NMR. The compounds were active against 9 out of 12 tested microorganisms including a resistant strain; vancomycin-resistant entrococci (VRE), Escherichia coli, Staphylococcus aureus and Candida albicans. The zones of inhibition ranged between 22 and 34 mm against the microorganisms. The minimum inhibitory concentration was as low as 6.25 μg/mL against Shigella dysentriae, Bacillus cereus and S. aureus while the minimum bactericidal concentration was as low as 50 μg/mL against Pseudomonas aeruginosa, VRE and C. albicans. This is the first report of the isolation of the compound.
authors.affiliation: a Department of Chemistry , Ahmadu Bello University Zaria , Zaria 810282 , Nigeria.
authors.forename: Nasir
authors.initials: N
authors.lastname: Tajuddeen
authors.affiliation: a Department of Chemistry , Ahmadu Bello University Zaria , Zaria 810282 , Nigeria.
authors.forename: Muhammad S
authors.initials: MS
authors.lastname: Sallau
authors.affiliation: b Department of Pharmaceutical and Medicinal Chemistry , Ahmadu Bello University Zaria , Zaria 810282 , Nigeria.
authors.forename: Aliyu M
authors.initials: AM
authors.lastname: Musa
authors.affiliation: b Department of Pharmaceutical and Medicinal Chemistry , Ahmadu Bello University Zaria , Zaria 810282 , Nigeria.
authors.forename: Sani M
authors.initials: SM
authors.lastname: Yahaya
authors.affiliation: a Department of Chemistry , Ahmadu Bello University Zaria , Zaria 810282 , Nigeria.
authors.forename: James D
authors.initials: JD
authors.lastname: Habila
authors.affiliation: c Department of Pharmaceutical and Medicinal Chemistry , Usmanu Danfodiyo University , Sokoto , Nigeria.
authors.forename: Abdullahi Musa
authors.initials: AM
authors.lastname: Ismail
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D029744:Commiphora / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D005419:Flavonoids; D010936:Plant Extracts
keywords: 2D NMR; Burseraceae; Commiphora pedunculata; VRE; flavonoids