title: Restless leg syndrome and multiple sclerosis: a case-control study in China.
abstract: BACKGROUND
  As a common neurological movement disorder, restless leg syndrome (RLS) is often seen in patients with multiple sclerosis (MS). However, the relationship between RLS and MS is still unclear. This case-control study aimed to measure RLS prevalence and uncover its association with MS, as well as to identify possible associated risk factors.
  
  
  METHODS
  Six hundred and ninety-five patients were randomly selected from a cohort of patients with MS at the Neurology Department of our hospital, and a group of age- and sex-matched healthy controls (n = 603) was enrolled from the general population. Using a face-to-face interview questionnaire, we collected data on RLS incidence in participants with or without MS. We further assessed sleep quality in all the participants.
  
  
  RESULTS
  We found there to be a significantly higher prevalence of RLS among patients with MS compared to healthy controls (odds ratio [OR], 3.8; P < 0.001). Risk factors such as an older MS age at onset and a longer MS duration were significantly associated with the presence of RLS. Furthermore, patients with both MS and RLS were more likely to suffer from sleep complaints compared to patients with MS without RLS.
  
  
  CONCLUSIONS
  RLS was significantly associated with MS and was found to have a significant impact on sleep quality, particularly in patients with MS.
authors.affiliation: Institute of Clinical Medicine, Department of Urology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She Dong Avenue, Zhengzhou, 450002, People's Republic of China.|Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She Dong Avenue, Zhengzhou, 450002, People's Republic of China.
authors.forename: Gangqiong
authors.initials: G
authors.lastname: Liu
authors.affiliation: Henan University, No. 85 Minglun Avenue, Kaifeng, 475001, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Feng
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She Dong Avenue, Zhengzhou, 450002, People's Republic of China.
authors.forename: Chao
authors.initials: C
authors.lastname: Lan
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She Dong Avenue, Zhengzhou, 450002, People's Republic of China.
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Zhu
authors.affiliation: Department of Emergency, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She Dong Avenue, Zhengzhou, 450002, People's Republic of China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She Dong Avenue, Zhengzhou, 450002, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Institute of Clinical Medicine, Department of Urology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She Dong Avenue, Zhengzhou, 450002, People's Republic of China. xuerui04301617@126.com.
authors.forename: Rui
authors.initials: R
authors.lastname: Xue
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004185:Disability Evaluation; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology*; D012148:Restless Legs Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors
keywords: China; Multiple sclerosis; Restless leg syndrome; Sleep