title: The paradoxical roles of C1q and C3 in autoimmunity.
abstract: In this review we will focus on the links between complement and autoimmune diseases and will highlight how animal models have provided insights into the manner by which C1q and C3 act to modulate both adaptive and innate immune responses. In particular we will highlight how C1q may not only act as initiator of the classical complement pathway, but can also mediate multiple immune responses in a complement activation independent manner.
authors.affiliation: Centre for Complement and Inflammation Research, Department of Medicine, Imperial College London, London, UK.
authors.forename: Diane
authors.initials: D
authors.lastname: Scott
authors.affiliation: Centre for Complement and Inflammation Research, Department of Medicine, Imperial College London, London, UK. Electronic address: m.botto@imperial.ac.uk.
authors.forename: Marina
authors.initials: M
authors.lastname: Botto
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000378:metabolism*; D015551:Autoimmunity; D015922:Complement C1q / Q000378:metabolism*; D003176:Complement C3 / Q000378:metabolism*; D003171:Complement Pathway, Classical; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D003176:Complement C3; D015922:Complement C1q
keywords: Autoimmunity; Complement; Systemic lupus erythematosus; Tolerance