title: Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.
abstract: Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulation of the LPS-induced pro-inflammatory IL-1b and NO production by down-regulating the expression of iNOS protein in RAW 264.7 macrophages.
authors.affiliation: Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia. yuna123@hotmail.my.
authors.forename: Chin-Soon
authors.initials: CS
authors.lastname: Phan
authors.affiliation: Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia. sheanyeaw90@hotmail.com.
authors.forename: Shean-Yeaw
authors.initials: SY
authors.lastname: Ng
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea. yellow6798@hanmail.net.
authors.forename: Eun-A
authors.initials: EA
authors.lastname: Kim
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Korea. youjinj@jejunu.ac.kr.
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
authors.affiliation: Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia. kishneth@yahoo.com.
authors.forename: Kishneth
authors.initials: K
authors.lastname: Palaniveloo
authors.affiliation: Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia. csv@ums.edu.my.
authors.forename: Charles Santhanaraju
authors.initials: CS
authors.lastname: Vairappan
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D053583:Interleukin-1beta / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism
chemical_list: D001688:Biological Products; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II
keywords: Capnella sp.; Nephtheidae; bicyclogermacrene; sesquiterpenoids; soft coral