title: Integration of PKR-dependent translation inhibition with innate immunity is required for a coordinated anti-viral response.
abstract: Viral triggering of the innate immune response in infected cells aims at delaying viral replication and prevents tissue spreading. Viral replication is delayed by host protein synthesis inhibition and infected cell apoptosis on one hand, while infection spreading is controlled by the synthesis of specific proteins like type-I interferons (IFNs) and pro-inflammatory cytokines on the other hand. How do these two apparent conflicting responses cooperate within the same infected cells to mount effective defenses against pathogens? What are the molecules or the complexes resolving this contradiction over time? Some recent studies reveal unanticipated connections between innate immunity and stress pathways, giving important clues on how the cellular responses are orchestrated to limit infection efficiently.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Dalet
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France; Institute for Research in Biomedicine - iBiMED and Aveiro Health Sciences Program, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: gatti@ciml.univ-mrs.fr.
authors.forename: Evelina
authors.initials: E
authors.lastname: Gatti
authors.affiliation: Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France; Institute for Research in Biomedicine - iBiMED and Aveiro Health Sciences Program, University of Aveiro, 3810-193 Aveiro, Portugal. Electronic address: pierre@ciml.univ-mrs.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Pierre
mesh_terms: D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D018384:Oxidative Stress; D014176:Protein Biosynthesis / Q000502:physiology*; D012367:RNA, Viral / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*; D019892:eIF-2 Kinase / Q000502:physiology*
chemical_list: D012367:RNA, Viral; D019892:eIF-2 Kinase
keywords: Innate immunity; RLR; Viral sensing