title: The use of cerebrospinal fluid and neuropathologic studies in neuropsychiatry practice and research.
abstract: The gold standard for diagnosis of neurodegenerative diseases (ie, Alzheimer disease, frontotemporal dementia, Parkinson disease, dementia with Lewy bodies, amyotrophic lateral sclerosis) is neuropathologic examination at autopsy. As such, laboratory studies play a central role in antemortem diagnosis of these conditions and their differentiation from the neuroinflammatory, infectious, toxic, and other nondegenerative etiologies (eg, rapidly progressive dementias) that are encountered in neuropsychiatric practice. This article summarizes the use of cerebrospinal fluid (CSF) laboratory studies in the diagnostic evaluation of dementia syndromes and emerging CSF biomarkers specific for underlying neuropathology in neurodegenerative disease research.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 550 North Broadway, Suite 305, Baltimore, MD 21205, USA.
authors.forename: Kalyani
authors.initials: K
authors.lastname: Kansal
authors.affiliation: Department of Neurology, Hospital of the University of Pennsylvania, University of Pennsylvania Perelman School of Medicine, 3 Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: dirwin@mail.med.upenn.edu.
authors.forename: David J
authors.initials: DJ
authors.lastname: Irwin
mesh_terms: D016229:Amyloid beta-Peptides / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000473:pathology*; D002555:Cerebrospinal Fluid / Q000378:metabolism / Q000382:microbiology; D004268:DNA-Binding Proteins / Q000032:analysis*; D003704:Dementia / Q000175:diagnosis / Q000209:etiology; D018450:Disease Progression; D006801:Humans; D019636:Neurodegenerative Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis / Q000382:microbiology; D058027:Neuropsychiatry / Q000379:methods; D051844:alpha-Synuclein / Q000032:analysis*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D004268:DNA-Binding Proteins; D051844:alpha-Synuclein
keywords: Alzheimer disease; Biomarkers; CSF; Dementia with Lewy bodies; Frontotemporal dementia; Neurodegenerative disease; Parkinson disease; Prion