title: A meta-analysis on relationship of MAOB intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD.
abstract: BACKGROUND
  To date, many studies have examined the correlation between Monoamine oxidase B (MAOB) intron 13 A/G polymorphisms and the susceptibility to Parkinson's disease (PD). However, the results of these studies are inconclusive.
  
  
  METHODS
  In order to confirm this correlation, a meta-analysis of 15 studies was performed and the dichotomous data are presented as odds ratios (ORs) and 95% confidence intervals (CIs).
  
  
  RESULTS
  Carriers of the MAOB intron 13 A allele were more likely to have PD than carriers of the G allele in the Asian population (OR = 1.182, 95% CI = 1.012-1.380, p < 0.05). When combined with the COMT LL genotype, the MAOB intron 13 AA/(A) genotype increased the risk of PD susceptibility more than with the GA genotype or GG + GA/(G) genotype (AA/(A) vs. GG + GA/(G): OR = 1.610, 95% CI = 1.094-2.369; AA/(A) vs. GA: OR = 1.621, 95% CI = 1.004-2.619). Irrespective of whether individuals were in the AA/(A) genotype or GG + GA/(G) genotype subgroup, this meta-analysis indicated that smoking was a PD-preventive factor (AA/(A): OR = 1.823, 95% CI = 1.150-2.891; GG + GA/(G): OR = 2.245, 95% CI = 1.277-3.948).
  
  
  CONCLUSIONS
  The results of this meta-analysis suggest that people with the MAOB intron 13 A allele have an increased risk of PD in the Asian population, especially when combined with the COMT LL genotype.
authors.affiliation: a The Affiliated Zhongshan Hospital of Dalian University , No. 6 Jiefang Street, Zhongshan District, Dalian, Liaoning, 116000, 471003, China.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: a The Affiliated Zhongshan Hospital of Dalian University , No. 6 Jiefang Street, Zhongshan District, Dalian, Liaoning, 116000, 471003, China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Piao
authors.affiliation: a The Affiliated Zhongshan Hospital of Dalian University , No. 6 Jiefang Street, Zhongshan District, Dalian, Liaoning, 116000, 471003, China.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Wu
authors.affiliation: a The Affiliated Zhongshan Hospital of Dalian University , No. 6 Jiefang Street, Zhongshan District, Dalian, Liaoning, 116000, 471003, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: a The Affiliated Zhongshan Hospital of Dalian University , No. 6 Jiefang Street, Zhongshan District, Dalian, Liaoning, 116000, 471003, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liang
mesh_terms: D000483:Alleles; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007438:Introns; D008995:Monoamine Oxidase / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D065840:Protective Factors; D012307:Risk Factors; D012907:Smoking
chemical_list: D008995:Monoamine Oxidase; C588010:COMT protein, human; D002394:Catechol O-Methyltransferase
keywords: MAOB gene; Parkinson's disease; meta-analysis; polymorphism