title: Improved method for synthesis of cysteine modified hyaluronic acid for in situ hydrogel formation.
abstract: We developed a new strategy for the functionalization of hyaluronic acid by chemical modification of its C-6 hydroxyl groups through an ether bond to obtain a cysteine-hyaluronic acid conjugate. This conjugate is suitable to prepare injectable and in situ formed hydrogels cross-linked by native chemical ligation and Michael addition under mild conditions.
authors.affiliation: Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Oceanography, Hainan University, Haikou, Hainan Province 570228, China. bhhu@hainu.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Sun
authors.forename: Lingzi
authors.initials: L
authors.lastname: Huangshan
authors.forename: Bi-Huang
authors.initials: BH
authors.lastname: Hu
authors.forename: Phillip B
authors.initials: PB
authors.lastname: Messersmith
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003545:Cysteine / Q000737:chemistry*; D006820:Hyaluronic Acid / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020100:Hydrogels; D006820:Hyaluronic Acid; D003545:Cysteine