title: Ca2+ signaling in cytoskeletal reorganization, cell migration, and cancer metastasis.
abstract: Proper control of Ca(2+) signaling is mandatory for effective cell migration, which is critical for embryonic development, wound healing, and cancer metastasis. However, how Ca(2+) coordinates structural components and signaling molecules for proper cell motility had remained elusive. With the advance of fluorescent live-cell Ca(2+) imaging in recent years, we gradually understand how Ca(2+) is regulated spatially and temporally in migrating cells, driving polarization, protrusion, retraction, and adhesion at the right place and right time. Here we give an overview about how cells create local Ca(2+) pulses near the leading edge, maintain cytosolic Ca(2+) gradient from back to front, and restore Ca(2+) depletion for persistent cell motility. Differential roles of Ca(2+) in regulating various effectors and the interaction of roles of Ca(2+) signaling with other pathways during migration are also discussed. Such information might suggest a new direction to control cancer metastasis by manipulating Ca(2+) and its associating signaling molecules in a judicious manner.
authors.affiliation: Department of Pharmacology, National Taiwan University College of Medicine, No. 1, Section 1, Ren-Ai Road, Taipei 100, Taiwan ; Department of Internal Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Road, Taipei 100, Taiwan.
authors.forename: Feng-Chiao
authors.initials: FC
authors.lastname: Tsai
authors.affiliation: Department of Pharmacology, National Taiwan University College of Medicine, No. 1, Section 1, Ren-Ai Road, Taipei 100, Taiwan.
authors.forename: Guan-Hung
authors.initials: GH
authors.lastname: Kuo
authors.affiliation: Department of Pharmacology, National Taiwan University College of Medicine, No. 1, Section 1, Ren-Ai Road, Taipei 100, Taiwan.
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Chang
authors.affiliation: Department of Pharmacology, National Taiwan University College of Medicine, No. 1, Section 1, Ren-Ai Road, Taipei 100, Taiwan.
authors.forename: Pei-Ju
authors.initials: PJ
authors.lastname: Tsai
mesh_terms: D020013:Calcium Signaling; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000473:pathology*
chemical_list: D026901:Membrane Transport Proteins