title: Four new neolignan glucosides from the fruits of Arctium lappa.
abstract: Four new neolignan glucosides named (7S, 8R)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-O-4'-neolignan-9'-O-β-d-apiofuranosyl-(1 → 6)-O-β-d-glucopyranoside (1), (8R)-4,9,9'-trihydroxy-3,3'-dimethoxy-7-oxo-8-O-4'-neolignan-4-O-β-d-glucopyranoside (2), (7R, 8S)-dihydrodehydrodiconiferyl alcohol-7'-oxo-4-O-β-d-glucopyranoside (3), and (7'S, 8'R, 8S)-4,4',9'-trihydroxy-3,3'-dimethoxy-7',9-epoxylignan-7-oxo-4-O-β-d-glucopyranoside (4) were isolated from the fruits of Arctium lappa L. Their structures and absolute configurations were elucidated on the basis of comprehensive spectroscopic analyses (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with known analogues in the literature.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Peking Union Medical College and Institute of Materia Medica, Chinese Academy of Medical Sciences , Beijing 100050 , China.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Huang
authors.forename: Zi-Ming
authors.initials: ZM
authors.lastname: Feng
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Yang
authors.forename: Jian-Shuang
authors.initials: JS
authors.lastname: Jiang
authors.forename: Pei-Cheng
authors.initials: PC
authors.lastname: Zhang
mesh_terms: D031170:Arctium / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010095:Oxotremorine / Q000031:analogs & derivatives; D013237:Stereoisomerism
chemical_list: D004365:Drugs, Chinese Herbal; D005960:Glucosides; D017705:Lignans; C042744:N-methylacetamide-oxotremorine M; D010095:Oxotremorine
keywords: Arctii Fructus; Arctium lappa; absolute configuration; neolignan glucosides