title: [Effects of 50 Hz sinusoidal electromagnetic field with different intensities on rat peak bone mass].
abstract: Studying effects of 50 Hz sinusoidal electromagnetic fields (SEMFs) with different intensities on peak bone mass (PBM) of rats may provide a theoretical basis for application of electromagnetic clinical field. 30 female SD rats, 6 weeks of age, were randomly divided into three groups: the control group, 0.1 mT electromagnetic field group (EMFs) and 0.6 mT EMFs. The EMFs groups were treated for 3 h/day. After 8 weeks, we examined their bone mineral densities (BMD) , measured their bone biomechanical properties, and made serum levels of osteocalcin (OC), tartrate-resistant acid phosphatase 5b (TRACP 5b), and histomorphometry. It was found that the BMD (P < 0.01), maximum mechanical load (P < 0.01) in the 0.1 mT group were significantly higher than those in the control group, and Yield strength (P < 0.05), the analyses of serum bone turnover markers and histomorphometric parameters were better than those in the control group (P < 0.05). However, the 0.6 mT group did not have significantly difference comparing with that in the control group. This study proved that 50 Hz 0.1 mT SEMFs can increased BMD, bone strength, and bone tissue microstructure. Therefore, 50 Hz 0.1 mT SEMFs can improve peak bone mass of rats.
authors.forename: Yuhai
authors.initials: Y
authors.lastname: Gao
authors.forename: Kui
authors.initials: K
authors.lastname: Cheng
authors.forename: Baofeng
authors.initials: B
authors.lastname: Ge
authors.forename: Ping
authors.initials: P
authors.lastname: Zhen
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Xiaoni
authors.initials: X
authors.lastname: Ma
authors.forename: Shaofeng
authors.initials: S
authors.lastname: Li
authors.forename: Keming
authors.initials: K
authors.lastname: Chen
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000502:physiology*; D004574:Electromagnetic Fields; D005260:Female; D007527:Isoenzymes / Q000097:blood; D015675:Osteocalcin / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D007527:Isoenzymes; D015675:Osteocalcin; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase