title: A Combined Transition-Metal-Catalyzed and Photopromoted Process: Synthesis of 2,3-Fused 4-Phenylnaphthalen-1-yl Carboxylates from 1,7-Diaryl-1,6-diynes.
abstract: 2,3-Fused 4-phenylnaphthalen-1-yl carboxylates were synthesized in a step- and atom-economical manner using a ruthenium-catalyzed hydrocarboxylative cyclization of 1,7-diaryl-1,6-diynes and subsequent oxidative photocyclization. The scope of this novel two-step process was demonstrated by the construction of diverse structures from substrates with various tethers and terminal aryl groups. Late-stage CH functionalizations of the arylnaphthalene product further enhance the synthetic potential of the developed process.
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601 (Japan). yamamoto-yoshi@ps.nagoya-u.ac.jp.
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601 (Japan).
authors.forename: Shota
authors.initials: S
authors.lastname: Mori
authors.affiliation: Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601 (Japan).
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Shibuya
keywords: cyclization; lignan; naphthol; photoreaction; ruthenium catalysis