title: [Six-year survival with recurrent intrahepatic cholangiocarcinoma achieved by simple S-1 administration].
abstract: We report here a rare case of a patient with recurrent intrahepatic cholangiocarcinoma that was treated with simple S-1 chemotherapy, who is still alive 6 years later. A liver tumor was identified in segments 5 to 6 in a 60-year-old male asymptomatic hepatitis B carrier. The tumor was diagnosed as hepatocellular carcinoma by MRI and CT. However, following its resection by extended posterior segmentectomy of the liver, pathological findings identified it as an intrahepatic cholangiocarcinoma. The surgical margin was cancer-negative. No additional adjuvant chemotherapy was administered because of the patient 's impaired renal function. When tumor recurrence was found by MRI 30 months later, an additional liver resection was planned but a laparotomy was eventually performed. This was because intraoperative findings revealed Glissonian sheath invasion with involvement of the umbilical portion. S-1 treatment(100mg/body/day)was started. Although the dose had to be reduced(mostly 75mg/body/day)due to hyperbilirubinemia and there were some interruptions in the regimen, in total of 42 g of S-1 was administered. The patient is currently still alive, 6 years after the detection of the tumor recurrence. This represents a rare case in patients with intrahepatic cholangiocarcinoma.
authors.affiliation: Dept. of Gastroenterological Surgery, Takamatsu Red Cross Hospital.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Miki
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Hirose
authors.forename: Takahito
authors.initials: T
authors.lastname: Minami
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Morioka
authors.forename: Takahisa
authors.initials: T
authors.lastname: Suzuki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Otani
authors.forename: Koji
authors.initials: K
authors.lastname: Kitamura
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Yoshitani
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Nishihira
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001650:Bile Duct Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D001653:Bile Ducts, Intrahepatic / Q000473:pathology* / Q000601:surgery; D006528:Carcinoma, Hepatocellular; D018281:Cholangiocarcinoma / Q000188:drug therapy* / Q000601:surgery; D003937:Diagnosis, Differential; D004338:Drug Combinations; D006498:Hepatectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000627:therapeutic use*; D012008:Recurrence; D005641:Tegafur / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid