title: Core-Shell Collagen Peptide Chelated Calcium/Calcium Alginate Nanoparticles from Fish Scales for Calcium Supplementation.
abstract: We report simple methods for preparing collagen peptide chelated calcium (cpcc) and a novel cpcc-loaded nanoparticle from marine fish scales for calcium supplementation. Cpcc nanoparticles have an average diameter of approximately 150 nm and a calcium content of up to 130.4 g/kg. Calcium alginate was selected to encapsulate cpcc for the preparation of core-shell cpcc/calcium alginate nanoparticles. The core-shell nanoparticles were mainly 200 to 500 nm in diameter. The ratio of calcium to sulfur was approximately 1.6:1. In vivo experiments indicated both cpcc and core-shell cpcc were able to improve calcium absorption and prevent calcium deficiency. Especially core-shell cpcc worked well to increase femur bone mineral density and femur calcium content in rats significantly. The study demonstrated that cpcc and core-shell cpcc nanoparticles were ideal for calcium supplementation.
  
  
  CONCLUSIONS
  Calcium deficiency has become an increasingly relevant health concern in the food industry. There is an urgent need for new effective calcium supplements. This study consisted of preparing and characterizing alginate nanoparticles loaded with collagen peptide chelated calcium. These nanoparticles can enhance calcium absorption significantly and prevent calcium deficiency. The data presented in this study can aid the food industry in developing a new ideal calcium supplement.
authors.affiliation: Engineering Research Center of Marine Biological Resource Comprehensive Utilization, Third Inst. of Oceanography, State Oceanic Administration, No.184 Daxue Road, Xiamen, Fujian Province, 361005, China.
authors.forename: Honghui
authors.initials: H
authors.lastname: Guo
authors.affiliation: Engineering Research Center of Marine Biological Resource Comprehensive Utilization, Third Inst. of Oceanography, State Oceanic Administration, No.184 Daxue Road, Xiamen, Fujian Province, 361005, China.
authors.forename: Zhuan
authors.initials: Z
authors.lastname: Hong
authors.affiliation: Engineering Research Center of Marine Biological Resource Comprehensive Utilization, Third Inst. of Oceanography, State Oceanic Administration, No.184 Daxue Road, Xiamen, Fujian Province, 361005, China.
authors.forename: Ruizao
authors.initials: R
authors.lastname: Yi
mesh_terms: D000464:Alginates / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D000818:Animals; D001682:Biological Availability; D001842:Bone and Bones / Q000187:drug effects; D003094:Collagen / Q000737:chemistry*; D019587:Dietary Supplements; D005399:Fishes; D020723:Glucuronic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D006603:Hexuronic Acids / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D010455:Peptides; D020723:Glucuronic Acid; D003094:Collagen
keywords: calcium supplementation; core-shell; fish scale; nanoparticle