title: PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction.
abstract: The spatial restriction of phosphorylated phosphoinositides generated downstream activated membrane receptors is critical for proper cell response to environmental cues. The α isoform of class II PI3Ks, PI3K-C2α, has emerged as a modulator of receptor localization, acting both in the control of receptor endocytosis and resensitization. This unexpectedly versatile enzyme was found to differentially produce two distinct 3-phosphorylated phosphoinositides and to selectively control distinct steps of vesicular traffic such as endocytosis and recycling. This review focuses on the latest discoveries regarding PI3K-C2α function in vesicle trafficking and its impact on cell biology and mammalian embryonic development.
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.
authors.forename: Carlo C
authors.initials: CC
authors.lastname: Campa
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Franco
authors.affiliation: Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy. Electronic address: emilio.hirsch@unito.it.
authors.forename: Emilio
authors.initials: E
authors.lastname: Hirsch
mesh_terms: D004789:Enzyme Activation; D007527:Isoenzymes / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D007527:Isoenzymes; D019869:Phosphatidylinositol 3-Kinases
keywords: Class II α-isoform of phosphatidylinositol 3-kinase; Endocytosis; Exocytosis; PI3K-C2α; Phosphoinositide; Signal transduction; Vesicle trafficking