title: Serum NT-proBNP on admission can predict ST-segment resolution in patients with acute myocardial infarction after primary percutaneous coronary intervention.
abstract: OBJECTIVE
  The aim of this study was to investigate the value of initial serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in ST-segment elevation myocardial infarction (STEMI) patients for predicting ST-segment resolution (STR) after primary percutaneous coronary intervention (pPCI).
  
  
  METHODS
  Consecutive STEMI patients (n = 218) who underwent pPCI were assigned to an STR group (≥ 50 % resolution) or a non-STR group (< 50 % resolution). All patients were followed up for 12 months, and major adverse cardiac events were recorded. Data related to the pPCI procedure, biochemical parameters, and cardiac markers were compared between the two groups. Predictive factors of non-STR were also identified.
  
  
  RESULTS
  STR at 180 min after pPCI occurred in 202 patients (92.7 %). Compared to the STR group, patients in the non-STR group had a significantly lower left ventricular ejection fraction, a larger left ventricular end-diastolic dimension, and significantly higher serum concentrations of glycosylated hemoglobin and NT-proBNP. Multivariate logistic regression analysis indicated that a high serum NT-proBNP level in STEMI patients on hospital admission was the only independent predictive factor of non-STR after pPCI. An NT-proBNP concentration of ≥ 2,563.6 pg/ml had a sensitivity of 81.2 % and a specificity of 65.8 %.
  
  
  CONCLUSIONS
  Serum NT-proBNP concentrations in STEMI patients on hospital admission were useful in predicting non-STR after pPCI.
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei Province, People's Republic of China. boshipb@163.com.|Department of Cardiology, The First People's Hospital of Chenzhou, No. 102, Luo Jia Jing, 423000, Chenzhou, Hunan Province, People's Republic of China. boshipb@163.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Peng
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei Province, People's Republic of China. XH1966@163.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Xia
authors.affiliation: Department of Cardiology, The First People's Hospital of Chenzhou, No. 102, Luo Jia Jing, 423000, Chenzhou, Hunan Province, People's Republic of China.
authors.forename: Aihua
authors.initials: A
authors.lastname: Ni
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei Province, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, 430060, Wuhan, Hubei Province, People's Republic of China.
authors.forename: Xuejun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D017677:Age Distribution; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D004562:Electrocardiography / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010343:Patient Admission / Q000706:statistics & numerical data*; D010446:Peptide Fragments / Q000097:blood*; D062645:Percutaneous Coronary Intervention / Q000401:mortality*; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Acute myocardial infarction; Myocardial reperfusion; N-terminal pro-brain natriuretic peptide; Primary percutaneous coronary intervention; ST-segment resolution