title: Pioneer translation products as an alternative source for MHC-I antigenic peptides.
abstract: The notion that alternative peptide substrates can be processed and presented to the MHC class I pathway has opened for new aspects on how the immune system detects infected or damaged cells. Recent works show that antigenic peptides are derived from intron sequences in pre-mRNAs target for the nonsense-mediated degradation pathway. Introns are spliced out co-transcriptionally suggesting that such pioneer translation products (PTPs) are synthesized on the nascent RNAs in the nuclear compartment to ensure that the first peptides to emerge from an mRNA are destined for the class I pathway. This illustrates an independent translation event during mRNA maturation that give rise to specific peptide products with a specific function in the immune system. The characterization of the translation apparatus responsible for PTP synthesis will pave the way for understanding how PTP production is regulated in different tissues under different conditions and will help designing new vaccine strategies.
authors.affiliation: Institut Gustave Roussy, Université Paris Sud, Unité 1015 département d'immunologie, 114, rue Edouard Vaillant, 94805 Villejuif, France. Electronic address: sebastien.apcher@inserm.fr.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Apcher
authors.affiliation: Equipe Labellisée la Ligue Contre le Cancer, Inserm UMR1162, Université Paris 7, Institut de Génétique Moléculaire, 27 rue Juliette Dodu, 75010 Paris, France.
authors.forename: Chrysoula
authors.initials: C
authors.lastname: Daskalogianni
authors.affiliation: Equipe Labellisée la Ligue Contre le Cancer, Inserm UMR1162, Université Paris 7, Institut de Génétique Moléculaire, 27 rue Juliette Dodu, 75010 Paris, France; RECAMO, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic. Electronic address: robin.fahraeus@inserm.fr.
authors.forename: Robin
authors.initials: R
authors.lastname: Fåhraeus
mesh_terms: D017951:Antigen Presentation / Q000235:genetics*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D002467:Cell Nucleus / Q000235:genetics / Q000276:immunology; D003600:Cytosol / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007438:Introns; D010455:Peptides / Q000235:genetics / Q000276:immunology*; D010588:Phagosomes / Q000235:genetics / Q000276:immunology; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000276:immunology; D014176:Protein Biosynthesis / Q000276:immunology*; D012322:RNA Precursors / Q000235:genetics / Q000276:immunology; D012326:RNA Splicing / Q000276:immunology*
chemical_list: D015395:Histocompatibility Antigens Class I; D010455:Peptides; D012322:RNA Precursors; D046988:Proteasome Endopeptidase Complex
keywords: Alternative mRNA translation products; MHC class I antigen presentation