title: The role of the tumor microenvironment in HIV-associated lymphomas.
abstract: There has been considerable interest in the role of the lymphoma microenvironment. Despite the use of highly active antiretroviral therapy (HAART), AIDS-related diffuse large-B-cell lymphoma remains common and HIV-relatedHIV-associated classical Hodgkin's lymphoma is increasing in incidence. Less is known about the impact HIV and HAART have on the lymphoma microenvironment. AIDS-related diffuse large B-cell lymphoma is highly angiogenic, demonstrates increased lymphoblastic histology, proliferation, increased activated cytotoxic T cells, reduced CD4(+) and FOXP3(+) T cells, but no differences in tumor-associated macrophages. Early initiation of HAART improves immunosurveillance, but cases without viral antigens appear able to avoid immunologic reaction. Increased T cell infiltrates seen with HAART treatment in HIV-related classical Hodgkin's lymphoma may contribute to malignant cell growth.
authors.affiliation: 1Barts Cancer Institute, Centre for Haemato-Oncology, Charterhouse Square, London, EC1M 6BQ, UK.
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Taylor
authors.affiliation: 1Barts Cancer Institute, Centre for Haemato-Oncology, Charterhouse Square, London, EC1M 6BQ, UK.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Liapis
authors.affiliation: 1Barts Cancer Institute, Centre for Haemato-Oncology, Charterhouse Square, London, EC1M 6BQ, UK.
authors.forename: John G
authors.initials: JG
authors.lastname: Gribben
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000473:pathology*; D059016:Tumor Microenvironment / Q000502:physiology*
keywords: HIV-related diffuse large B-cell lymphoma; Hodgkin's lymphoma; Tat; angiogenesis; immunosurveillance; impact of highly active antiretroviral therapy; p17; tumor microenvironment