title: Mitochondrial degradation and energy metabolism.
abstract: Mitochondria are intracellular power plants that feed most eukaryotic cells with the ATP produced by the oxidative phosphorylation (OXPHOS). Mitochondrial energy production is controlled by many regulatory mechanisms. The control of mitochondrial mass through both mitochondrial biogenesis and degradation has been proposed to be one of the most important regulatory mechanisms. Recently, autophagic degradation of mitochondria has emerged as an important mechanism involved in the regulation of mitochondrial quantity and quality. In this review, we highlight the intricate connections between mitochondrial energy metabolism and mitochondrial autophagic degradation by showing the importance of mitochondrial bioenergetics in this process and illustrating the role of mitophagy in mitochondrial patho-physiology. Furthermore, we discuss how energy metabolism could coordinate the biogenesis and degradation of this organelle.
authors.affiliation: EA4576, Maladies Rares: Génétique et Métabolisme, 33000 Bordeaux Cedex, France; Université de Bordeaux, 33077 Bordeaux, France; Commonwealth Scientific and Industrial Research Organisation CSIRO, Private Bag No. 5, Wembley, WA 6913, Australia.
authors.forename: Su
authors.initials: S
authors.lastname: Melser
authors.affiliation: EA4576, Maladies Rares: Génétique et Métabolisme, 33000 Bordeaux Cedex, France; Université de Bordeaux, 33077 Bordeaux, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Lavie
authors.affiliation: Université de Bordeaux, 33077 Bordeaux, France; INSERM U862, Neurocentre Magendie, Physiopathologie de la plasticité neuronale, Endocannabinoids and Neuroadaptation, 33077 Bordeaux, France. Electronic address: giovanni.benard@inserm.fr.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bénard
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D063154:Mitochondrial Dynamics / Q000502:physiology*
keywords: Mitochondrial energy metabolism; Mitochondrial turnover; Mitophagy