title: Enabling [(18)F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [(18)F]-anti-microRNA-21 as an example.
abstract: A bicyclononyne-based prosthetic group has been developed for (18)F-labeling of anti-microRNA-21, an oligonucleotide, in a near-stoichiometric manner.
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland. xiali@utu.fi.
authors.forename: Xiang-Guo
authors.initials: XG
authors.lastname: Li
authors.forename: Anne
authors.initials: A
authors.lastname: Roivainen
authors.forename: Jörgen
authors.initials: J
authors.lastname: Bergman
authors.forename: Arttu
authors.initials: A
authors.lastname: Heinonen
authors.forename: Frank
authors.initials: F
authors.lastname: Bengel
authors.forename: Thomas
authors.initials: T
authors.lastname: Thum
authors.forename: Juhani
authors.initials: J
authors.lastname: Knuuti
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D005462:Fluorine Radioisotopes; D035683:MicroRNAs; D009841:Oligonucleotides / Q000737:chemistry*; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D001643:Bridged Bicyclo Compounds; D005462:Fluorine Radioisotopes; C524940:MIRN21 microRNA, human; D035683:MicroRNAs; D009841:Oligonucleotides; C556617:bicyclo(6.1.0)nonyne