title: Lack of association between the ATP13A2 A746T variant and Parkinson's disease susceptibility in Han Chinese: a meta-analysis.
abstract: OBJECTIVE
  To perform a meta-analysis to help resolve the controversy of whether the ATP13A2 A746T variant is associated with Parkinson's disease (PD) susceptibility in Han Chinese.
  
  
  METHODS
  Six literature databases were searched for case-control studies published up to October 2014: Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang and SinoMed.
  
  
  RESULTS
  Five eligible articles were identified, which reported six case-control studies and a total of 1703 cases and 2050 controls. The overall results suggested low frequencies of the A746T variant in Han Chinese patients (9/1703, 0.55%) and controls (6/2050, 0.29%). We failed to find evidence of significant differences in variant frequencies among Han Chinese, Uyghur and Japanese patients (p = 0.263). Analysis of pooled odds ratios (ORs) and 95% confidence interval (CIs) revealed no association between the A746T variant and overall PD risk (GA vs. GG: OR 1.78, 95%CI 0.71-4.46, p = 0.216; allele A vs. G: OR 1.90, 95%CI 0.77-4.69, p = 0.167).
  
  
  CONCLUSIONS
  The ATP13A2 A746T variant is rare in Han Chinese patients and controls and is not associated with PD susceptibility in this ethnic group. Variant frequencies do not differ significantly among Han Chinese, Uyghur and Japanese patients. Further well-designed studies with larger samples are needed to validate these results.
authors.affiliation: a Department of Neurology, The People's Hospital of Yichun City , Yichun University , Yichun , Jiangxi Province ,. P.R China.
authors.forename: Li-Shou
authors.initials: LS
authors.lastname: Pan
authors.affiliation: a Department of Neurology, The People's Hospital of Yichun City , Yichun University , Yichun , Jiangxi Province ,. P.R China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: a Department of Neurology, The People's Hospital of Yichun City , Yichun University , Yichun , Jiangxi Province ,. P.R China.
authors.forename: Dan
authors.initials: D
authors.lastname: Ding
authors.affiliation: a Department of Neurology, The People's Hospital of Yichun City , Yichun University , Yichun , Jiangxi Province ,. P.R China.
authors.forename: Xue-Peng
authors.initials: XP
authors.lastname: Zhu
authors.affiliation: a Department of Neurology, The People's Hospital of Yichun City , Yichun University , Yichun , Jiangxi Province ,. P.R China.
authors.forename: Hui-Lin
authors.initials: HL
authors.lastname: Leng
authors.affiliation: a Department of Neurology, The People's Hospital of Yichun City , Yichun University , Yichun , Jiangxi Province ,. P.R China.
authors.forename: Xin-Bo
authors.initials: XB
authors.lastname: Deng
authors.affiliation: b Department of Neurology, West China Hospital , Sichuan University , Chengdu , Sichuan Province , P.R. China.
authors.forename: Yan-Ming
authors.initials: YM
authors.lastname: Xu
mesh_terms: D002681:China / Q000208:ethnology; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics*; D006180:Proton-Translocating ATPases / Q000235:genetics*
chemical_list: C514983:ATP13A2 protein, human; D006180:Proton-Translocating ATPases
keywords: A746T; ATP13A2; Han Chinese; Parkinson's disease