title: Kaempferia parviflora extract increases whole-body energy expenditure in humans: roles of brown adipose tissue.
abstract: Kaempferia parviflora extract (KP) has been reported to have a preventive effect on obesity in mice, probably by increasing energy expenditure (EE). The aims of the current study were to examine the acute effects of KP ingestion on whole-body EE in humans and to analyze its relation to the activity of brown adipose tissue (BAT), a site of non-shivering thermogenesis. After an oral ingestion of an ethanol extract of KP, EE increased significantly, showing a maximal increase of 229±69 kJ/d at 60 min, while it did not change after placebo ingestion. To evaluate BAT activity, the subjects underwent fluorodeoxyglucose-positron emission tomography, and divided into two groups with high- and low-BAT activities. A similar and greater response of EE to KP ingestion was observed in the high-BAT group (351±50 kJ/d at 60 min), but not in the low activity group. Placebo ingestion did not cause any significant EE change in either group. These results indicate that a single oral ingestion of the KP extract can potentially increase whole-body EE probably through the activation of BAT in healthy men, and may be useful as an anti-obesity regimen.
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College.
authors.forename: Mami
authors.initials: M
authors.lastname: Matsushita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoneshiro
authors.forename: Sayuri
authors.initials: S
authors.lastname: Aita
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Kamiya
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kusaba
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Kinya
authors.initials: K
authors.lastname: Takagaki
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kameya
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugie
authors.forename: Masayuki
authors.initials: M
authors.lastname: Saito
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000378:metabolism; D000328:Adult; D004734:Energy Metabolism / Q000187:drug effects*; D006801:Humans; D008297:Male; D009765:Obesity / Q000378:metabolism* / Q000517:prevention & control; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D049268:Positron-Emission Tomography / Q000379:methods; D022722:Thermogenesis / Q000187:drug effects*; D055815:Young Adult; D030521:Zingiberaceae
chemical_list: D010936:Plant Extracts