title: Impact of pharmaceutical excipients on in vitro association of saquinavir to chylomicrons.
abstract: This study was performed to investigate the impact of pharmaceutical excipients commonly used for lymphatic transport on in vitro drug association with chylomicrons (CM). A CM association study was conducted using saquinavir solubilized in four different pharmaceutical excipients. We observed a linear relationship between saquinavir solubility and drug association, suggesting that the solubility of saquinavir in excipients is a key determinant for successful lymphatic delivery. Broadly, these results suggest that excipients with good solubilization properties may be advantageous for enhancing lymphatic drug delivery.
authors.forename: J
authors.initials: J
authors.lastname: Ro
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Hwang
authors.forename: G
authors.initials: G
authors.lastname: Yun
authors.forename: J
authors.initials: J
authors.lastname: Lee
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical; D002914:Chylomicrons / Q000737:chemistry*; D005079:Excipients; D008297:Male; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D019258:Saquinavir / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D012995:Solubility
chemical_list: D019380:Anti-HIV Agents; D002914:Chylomicrons; D005079:Excipients; D019258:Saquinavir