title: Epidermal growth factor receptor inhibitors related trichomegaly of Eyelashes.
abstract: Advances in understanding of the mechanisms involved in oncogenesis have led to the development of targeted therapies such as epidermal growth factor receptor inhibitors (EGFRIs), targeting a variety of molecular structures and able to inhibit aberrantly activated oncogenic pathways. Their use made treatment more tolerable with significant reduction of systemic adverse effects. However, EGFRIs are associated with toxicities affecting the skin and adnexal structures that affect the majority of treated patients. Trichomegaly of eyelashes is a unique side-effect, seen in prolonged treatment with EGFRI. It is essential to be familiar with this adverse effect, its potential complications, long-term sequelae, and available effective treatment strategy in order to appropriately manage these patients.
authors.affiliation: Department of Medical Oncology , M S Ramaiah Medical College , Bangalore , India.
authors.forename: Vinayak V
authors.initials: VV
authors.lastname: Maka
authors.affiliation: Department of Ophthalmology , Vijayanagar Institute of Medical Sciences , Bellary , India.
authors.forename: Hithashree
authors.initials: H
authors.lastname: Rajanna
authors.affiliation: Department of Medical Oncology , M S Ramaiah Medical College , Bangalore , India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Narasiyappah
authors.affiliation: Department of Medical Oncology , M S Ramaiah Medical College , Bangalore , India.
authors.forename: Rohith
authors.initials: R
authors.lastname: Chitrapur
authors.affiliation: Department of Medical Oncology , M S Ramaiah Medical College , Bangalore , India.
authors.forename: Nalini
authors.initials: N
authors.lastname: Kilara