title: Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis.
abstract: We have developed methotrexate (MTX)-loaded poly(lactic-co-glycolic acid, PLGA) gold (Au)/iron (Fe)/gold (Au) half-shell nanoparticles conjugated with arginine-glycine-aspartic acid (RGD), which can be applied for magnetic targeted chemo-photothermal treatment, and in vivo multimodal imaging of rheumatoid arthritis (RA). Upon near-infrared (NIR) irradiation, local heat is generated at the inflammation region due to the NIR resonance of Au half-shells and MTX release from PLGA nanoparticles is accelerated. The Fe half-shell layer embedded between the Au half-shell layers enables in vivo T2-magnetic resonance (MR) imaging in addition to NIR absorbance imaging. Furthermore, the delivery of the nanoparticles to the inflammation region in collagen-induced arthritic (CIA) mice, and their retention can be enhanced under external magnetic field. When combined with consecutive NIR irradiation and external magnetic field application, these nanoparticles provide enhanced therapeutic effects with an MTX dosages of only 0.05% dosage compared to free MTX therapy for the treatment of RA.
authors.affiliation: Nanomedical Graduate Program, Yonsei University, Seoul 120-749, Republic of Korea.
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Nanomedical Graduate Program, Yonsei University, Seoul 120-749, Republic of Korea.
authors.forename: Sun-Mi
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Institute for Immunology and Immunological Disease, Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul 120-752, Republic of Korea.
authors.forename: Kyu-Hyung
authors.initials: KH
authors.lastname: Park
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Institute for Immunology and Immunological Disease, Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul 120-752, Republic of Korea.
authors.forename: Chin Hee
authors.initials: CH
authors.lastname: Mun
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Institute for Immunology and Immunological Disease, Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul 120-752, Republic of Korea. Electronic address: YONGBPARK@yuhs.ac.
authors.forename: Yong-Beom
authors.initials: YB
authors.lastname: Park
authors.affiliation: Nanomedical Graduate Program, Yonsei University, Seoul 120-749, Republic of Korea; Department of Physics, Yonsei University, Seoul 120-749, Republic of Korea. Electronic address: khyoo@yonsei.ac.kr.
authors.forename: Kyung-Hwa
authors.initials: KH
authors.lastname: Yoo
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000008:administration & dosage; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology*; D003131:Combined Modality Therapy / Q000379:methods; D003287:Contrast Media / Q000138:chemical synthesis; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis; D004058:Diffusion; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use; D007501:Iron / Q000737:chemistry / Q000627:therapeutic use; D008027:Light; D060526:Magnetic Fields; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008727:Methotrexate / Q000008:administration & dosage* / Q000737:chemistry; D051379:Mice; D008811:Mice, Inbred DBA; D057054:Molecular Imaging / Q000379:methods; D053769:Nanocapsules / Q000737:chemistry / Q000528:radiation effects / Q000627:therapeutic use*; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry; D020349:Surface Plasmon Resonance / Q000379:methods; D000068936:Theranostic Nanomedicine / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D003287:Contrast Media; D003692:Delayed-Action Preparations; D053769:Nanocapsules; D017319:Photosensitizing Agents; D006046:Gold; D007501:Iron; D008727:Methotrexate
keywords: Au/Fe/Au plasmonic nanoparticles; Chemo-photothermal treatment; Dual in vivo imaging; Magnetic targeting; Rheumatoid arthritis