title: miR-27a rs895819 polymorphism and risk of cancer in Chinese population: a meta-analysis.
abstract: OBJECTIVE
  Previous studies have evaluated the association between miR-27a rs895819 polymorphism and cancer risk in Chinese population, but the results were inconclusive. The present meta-analysis was conducted to clarify these controversies.
  
  
  METHODS
  A comprehensive search was conducted to identify all relevant case-control studies of miR-27a rs895819 polymorphism and cancer risk in Chinese participants. We calculated odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of any association.
  
  
  RESULTS
  A total of 12 case-control studies involving 2655 cases and 3106 controls were included. Overall, the results suggested that there was no significant association between miR-27a rs895819 polymorphism and cancer risk in Chinese population (OR = 1.14, 95%CI 0.86 to1.15, P = 0.85 for GG vs. AA). In the subgroup analysis by the source of controls, no significant association was found either among hospital-based group (OR = 1.16, 95%CI 0.78 to 1.73) or population-based group (OR = 1.06, 95%CI 0.74 to 1.35). However, when stratified by cancer types, we found a significant association between the polymorphism with colorectal cancer (OR = 1.56, 95%CI 1.01 to 2.40 for GG vs. AA).
  
  
  CONCLUSIONS
  miR-27a rs895819 polymorphism was associated with increased risk of colorectal cancer in Chinese population.
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, China.
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
mesh_terms: D002681:China / Q000453:epidemiology; D004273:DNA, Neoplasm / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009017:Morbidity; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D004273:DNA, Neoplasm; C531388:MIRN27 microRNA, human; D035683:MicroRNAs
keywords: Cancer; meta‐analysis; miR‐27a; single nucleotide polymorphism