title: The role of EMMPRIN in T cell biology and immunological diseases.
abstract: EMMPRIN (CD147), originally described as an inducer of the expression of MMPs, has gained attention in its involvement in various immunologic diseases, such that anti-EMMPRIN antibodies are considered as potential therapeutic medications. Given that MMPs are involved in the pathogenesis of various disease states, it is relevant that targeting an upstream inducer would make for an effective therapeutic strategy. Additionally, EMMPRIN is now appreciated to have multiple roles apart from MMP induction, including in cellular functions, such as migration, adhesion, invasion, energy metabolism, as well as T cell activation and proliferation. Here, we review what is known about EMMPRIN in numerous immunologic/inflammatory disease conditions with a particular focus on its complex roles in T cell biology.
authors.affiliation: Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.
authors.forename: Jennifer Nancy
authors.initials: JN
authors.lastname: Hahn
authors.affiliation: Hotchkiss Brain Institute, University of Calgary, Alberta, Canada.
authors.forename: Deepak Kumar
authors.initials: DK
authors.lastname: Kaushik
authors.affiliation: Hotchkiss Brain Institute, University of Calgary, Alberta, Canada vyong@ucalgary.ca.
authors.forename: V Wee
authors.initials: VW
authors.lastname: Yong
mesh_terms: D000818:Animals; D051926:Basigin / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology / Q000503:physiopathology*; D051379:Mice; D018345:Mice, Knockout; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: C497886:BSG protein, human; D051926:Basigin
keywords: T cell activation; adhesion; invasion; migration; proliferation