title: Neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis: a case report and the chemotherapy response.
abstract: Neuroendocrine carcinoma as a somatic-type malignancy (STM) arising in an extragonadal teratoma is extremely rare. The effect of chemotherapy has been poorly evaluated in such cases contrary to teratomas with other STMs. We herein demonstrate that systemic chemotherapy may be beneficial in a case of neuroendocrine carcinoma arising in a mediastinal teratoma with pulmonary metastasis. A 31-year-old man presented with mediastinal widening visualized on a chest radiograph. Computed tomography showed a huge mediastinal mass with two pulmonary nodules. Surgical resection confirmed the presence of a neuroendocrine carcinoma arising in a mediastinal teratoma and pulmonary metastasis. The patient subsequently received chemotherapy and has had no recurrence during the 28-month follow-up.
authors.affiliation: Department of Internal Medicine, Kyungpook National University, School of Medicine, South Korea.
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Lee
authors.forename: Young Min
authors.initials: YM
authors.lastname: Jo
authors.forename: Jaehee
authors.initials: J
authors.lastname: Lee
authors.forename: Seung Ick
authors.initials: SI
authors.lastname: Cha
authors.forename: Tae In
authors.initials: TI
authors.lastname: Park
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Kim
mesh_terms: D000328:Adult; D018278:Carcinoma, Neuroendocrine / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology*; D008853:Microscopy; D055613:Multiple Pulmonary Nodules / Q000000981:diagnostic imaging; D013724:Teratoma / Q000473:pathology*; D014057:Tomography, X-Ray Computed