title: Progression of gyrate atrophy measured with ultra-wide-field imaging.
abstract: The study aims to determine the progression of gyrate atrophy by measuring the area growth of chorioretinal atrophic lesions using ultra-wide-field images (UWFI). A retrospective, observational, and comparative study was conducted and UWFI (200°) were obtained from two patients with gyrate atrophy at baseline and follow-up. Measurements of atrophy were obtained for three types of lesions: Solitary atrophic lesions (SAL), De novo solitary lesions (DNSL), and peripapillary atrophy (PPA). Comparison of baseline and follow-up was done using t tests. Two patients with gyrate atrophy were included. Patient 1 presented 16 SAL, 5 DNSL, and PPA measured for both eyes (BE). Overall area growth (OAG) for SAL (expressed in decimals) presented a mean of 3.41, σ 3.07. DNSL area for BE presented a mean of 1586.08 P (2), σ 1069.55. OAG for PPA presented a mean of 1.21, σ 0.17. Patient 2 presented 5 SAL, no DNSL, and PPA was measured for BE. OAG for SAL presented a mean of 1.58, σ 1.05 (range 1.02-3.47). OAG for PPA presented a mean of 1.05, σ 0.001. Gyrate atrophy progression can be determined by measuring the changes in area using UWFI.
authors.affiliation: Department of Ophthalmology, Denver Health Medical Center, 777 Bannock St., Denver, CO, 80204, USA. salcedovilla@gmail.com.|Rocky Mountains Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Ct., Aurora, CO, 80045, USA. salcedovilla@gmail.com.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Salcedo-Villanueva
authors.affiliation: Department of Ophthalmology, Denver Health Medical Center, 777 Bannock St., Denver, CO, 80204, USA.|Rocky Mountains Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Ct., Aurora, CO, 80045, USA.
authors.forename: Miguel
authors.initials: M
authors.lastname: Paciuc-Beja
authors.affiliation: Asociación Para Evitar la Ceguera en México, Vicente García Torres # 46, 04030, Mexico, DF, Mexico.
authors.forename: Cristina
authors.initials: C
authors.lastname: Villanueva-Mendoza
authors.affiliation: Department of Ophthalmology, Denver Health Medical Center, 777 Bannock St., Denver, CO, 80204, USA.
authors.forename: Mariana
authors.initials: M
authors.lastname: Harasawa
authors.affiliation: Rocky Mountains Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Ct., Aurora, CO, 80045, USA.
authors.forename: Jesse M
authors.initials: JM
authors.lastname: Smith
authors.affiliation: Rocky Mountains Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Ct., Aurora, CO, 80045, USA.
authors.forename: Raul
authors.initials: R
authors.lastname: Velez-Montoya
authors.affiliation: Rocky Mountains Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Ct., Aurora, CO, 80045, USA.
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Olson
authors.affiliation: Rocky Mountains Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Ct., Aurora, CO, 80045, USA.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Oliver
authors.affiliation: Rocky Mountains Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Ct., Aurora, CO, 80045, USA.
authors.forename: Naresh
authors.initials: N
authors.lastname: Mandava
authors.affiliation: Department of Ophthalmology, Denver Health Medical Center, 777 Bannock St., Denver, CO, 80204, USA.|Rocky Mountains Lions Eye Institute, University of Colorado School of Medicine, 1675 Aurora Ct., Aurora, CO, 80045, USA.
authors.forename: Hugo
authors.initials: H
authors.lastname: Quiroz-Mercado
mesh_terms: D000328:Adult; D002829:Choroid / Q000473:pathology; D003941:Diagnostic Techniques, Ophthalmological; D018450:Disease Progression; D005260:Female; D015799:Gyrate Atrophy / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D010781:Photography; D012160:Retina / Q000473:pathology; D012162:Retinal Degeneration / Q000473:pathology; D012189:Retrospective Studies
keywords: Choroid; Gyrate atrophy; Retina; Retina pigment epithelium; Retinal distrophies