title: Diverse functions of miR-373 in cancer.
abstract: MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. They are involved in almost all cellular processes, and many have been described as potential oncogenes or tumor suppressors. MicroRNA-373 (miR-373), which was first identified as a human embryonic stem cell (ESC)-specific miRNA, is suggested to be implicated in the regulation of cell proliferation, apoptosis, senescence, migration and invasion, as well as DNA damage repair following hypoxia stress. Deregulation of miR-373 has been demonstrated in a number of cancers, whether it acts as an oncogene or a tumor suppressor, however, seems to be context dependent. In this review, we focus on the diverse functions of miR-373 and its implication in cancers.
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, 18877 Jingshi Road, 250062, Jinan, Shandong, People's Republic of China. freya0125@hotmail.com.
authors.forename: Furong
authors.initials: F
authors.lastname: Wei
authors.affiliation: Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China. cch0309@163.com.
authors.forename: Chuanhua
authors.initials: C
authors.lastname: Cao
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, 18877 Jingshi Road, 250062, Jinan, Shandong, People's Republic of China. xuxiaoqunsd@163.com.
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Xu
authors.affiliation: Institute of Basic Medicine, Shandong Academy of Medical Sciences, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, 18877 Jingshi Road, 250062, Jinan, Shandong, People's Republic of China. wjf_1030@126.com.
authors.forename: Junfu
authors.initials: J
authors.lastname: Wang
mesh_terms: D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000502:physiology; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D004249:DNA Damage; D004260:DNA Repair; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D000860:Hypoxia; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000502:physiology*; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D009857:Oncogenes; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C527114:MIRN373 microRNA, human; D035683:MicroRNAs