title: [Analysis of heavy-metal-mediated disease and development of a novel remediation system based on fieldwork and experimental research].
abstract: Heavy-metal pollution occurs in various environments, including water, air and soil, and has serious effects on human health. Since heavy-metal pollution in drinking water causes various diseases including skin cancer, it has become a global problem worldwide. However, there is limited information on the mechanism of development of heavy-metal-mediated disease. We performed both fieldwork and experimental studies to elucidate the levels of heavy-metal pollution and mechanisms of development of heavy-metal-related disease and to develop a novel remediation system. Our fieldwork in Bangladesh, Vietnam and Malaysia demonstrated that drinking well water in these countries was polluted with high concentrations of several heavy metals including arsenic, barium, iron and manganese. Our experimental studies based on the data from our fieldwork demonstrated that these heavy metals caused skin cancer and hearing loss. Further experimental studies resulted in the development of a novel remediation system with which toxic heavy metals were absorbed from polluted drinking water. Implementation of both fieldwork and experimental studies is important for prediction, prevention and therapy of heavy-metal-mediated diseases.
authors.affiliation: Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yajima
authors.forename: Cunchao
authors.initials: C
authors.lastname: Zou
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Chizuru
authors.initials: C
authors.lastname: Nakano
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Omata
authors.forename: Mayuko Y
authors.initials: MY
authors.lastname: Kumasaka
mesh_terms: D001459:Bangladesh; D060766:Drinking Water / Q000737:chemistry*; D034381:Hearing Loss / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D008296:Malaysia; D019216:Metals, Heavy / Q000009:adverse effects* / Q000032:analysis*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D014744:Vietnam; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000032:analysis*; D014877:Water Pollution, Chemical / Q000009:adverse effects* / Q000032:analysis*; D018508:Water Purification / Q000379:methods
chemical_list: D060766:Drinking Water; D019216:Metals, Heavy; D014874:Water Pollutants, Chemical