title: Ameliorating effects of Tamarindus indica fruit extract on anti-tubercular drugs induced liver toxicity in rats.
abstract: The study aimed to evaluate the hepatoprotective potential of aqueous extract of Tamarindus indica fruit against combination of two antitubercular drugs viz. Isoniazid and Rifampicin induced hepatotoxicity in rats. In vitro antioxidant activity of aqueous extract of T. indica by DPPH-HPLC method was found to be 81.48%. Treatment with aqueous extract of T. indica significantly reduced the elevated levels of biochemical markers such as SGOT, SGPT, ALP, bilirubin, TBARS and increased the albumin level as well antioxidant activities of SOD, CAT and GSH in intoxicated rats. The biochemical changes were supported by histological observations. Results of this study clearly demonstrate that aqueous extract of T. indica fruit protects against anti tuberculosis induced oxidative liver damage in rats and thus possess significant hepatoprotective activity. Further, it could be suggested that supplementation with this food extract might prove beneficial in the individuals on anti-TB drugs.
authors.affiliation: a Bioactive Natural Product Laboratory, Department of Pharmacognosy and Phytochemistry , Faculty of Pharmacy, Jamia Hamdard , New Delhi-62 , India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Amir
authors.affiliation: b Department of Pharmacology , Faculty of Pharmacy, Jamia Hamdard , New Delhi-62 , India.
authors.forename: Mohammad Ahmed
authors.initials: MA
authors.lastname: Khan
authors.affiliation: a Bioactive Natural Product Laboratory, Department of Pharmacognosy and Phytochemistry , Faculty of Pharmacy, Jamia Hamdard , New Delhi-62 , India.
authors.forename: Sayeed
authors.initials: S
authors.lastname: Ahmad
authors.affiliation: b Department of Pharmacology , Faculty of Pharmacy, Jamia Hamdard , New Delhi-62 , India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Akhtar
authors.affiliation: a Bioactive Natural Product Laboratory, Department of Pharmacognosy and Phytochemistry , Faculty of Pharmacy, Jamia Hamdard , New Delhi-62 , India.
authors.forename: Mohd
authors.initials: M
authors.lastname: Mujeeb
authors.affiliation: c Health Information Technology Department , Jeddah Community College, King Abdulaziz University , Jeddah , Kingdom of Saudi Arabia.
authors.forename: Aftab
authors.initials: A
authors.lastname: Ahmad
authors.affiliation: d Department of Pharmacy , Oman Medical College , Muscat , Oman.
authors.forename: Shah Alam
authors.initials: SA
authors.lastname: Khan
authors.affiliation: e Department of Biochemistry , Faculty of Science, King Abdulaziz University , Jeddah , Kingdom of Saudi Arabia.
authors.forename: Fahad A
authors.initials: FA
authors.lastname: Al-Abbasi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D000995:Antitubercular Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D005260:Female; D005638:Fruit / Q000737:chemistry; D007538:Isoniazid / Q000009:adverse effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012293:Rifampin / Q000009:adverse effects; D029861:Tamarindus / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D000995:Antitubercular Agents; D010936:Plant Extracts; D007538:Isoniazid; D012293:Rifampin
keywords: DPPH–HPLC; Tamarindus indica; hepatoprotective; tuberculosis