title: Highly diastereoselective synthesis of spiropyrazolones.
abstract: We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.
authors.affiliation: Faculty of Natural & Environmental Sciences, University of Southampton Highfield Campus, Southampton SO17 1BJ, UK. vc2g12@soton.ac.uk.
authors.forename: Victor
authors.initials: V
authors.lastname: Ceban
authors.affiliation: Faculty of Natural & Environmental Sciences, University of Southampton Highfield Campus, Southampton SO17 1BJ, UK. tolomola@gmail.com.|Department of Chemistry, Obafemi Awolowo University, Ile-Ife 220005, Nigeria. tolomola@gmail.com.
authors.forename: Temitope O
authors.initials: TO
authors.lastname: Olomola
authors.affiliation: Faculty of Natural & Environmental Sciences, University of Southampton Highfield Campus, Southampton SO17 1BJ, UK. mm3v12@soton.ac.uk.
authors.forename: Marta
authors.initials: M
authors.lastname: Meazza
authors.affiliation: Faculty of Natural & Environmental Sciences, University of Southampton Highfield Campus, Southampton SO17 1BJ, UK. R.Rios-Torres@southampton.ac.uk.
authors.forename: Ramon
authors.initials: R
authors.lastname: Rios
mesh_terms: D000588:Amines / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D047069:Pyrazolones / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D047069:Pyrazolones; D013141:Spiro Compounds
keywords: cascade reaction; diastereoselective; spiropyrazolones