title: The impact of taxane-based preoperative chemotherapy in gastroesophageal signet ring cell adenocarcinomas.
abstract: The benefit of preoperative chemotherapy in resectable gastroesophageal adenocarcinomas was not observed in signet ring cell subtype. However, the potential interest of taxane-based preoperative chemotherapy on this subtype is still an unresolved issue. Nineteen patients with localized signet ring cell adenocarcinomas received taxane-based regimens, and 17 patients underwent surgery. Complete resection was achieved in 80 %, and median overall survival was 40.8 months (95 % confidence interval (CI), 20.2-not reached). Even though one patient achieved a complete pathological response, seven patients had an upstaging of their tumors at surgery. The potential benefits of taxane-based chemotherapy seem to be limited to a reduced number of patients.
authors.affiliation: Department of Medical Oncology, University Hospital of Besancon, 3 Boulevard Alexander Fleming, Besancon, F-25030, France. chkim@chu-besancon.fr.|Clinical Investigational Centre, CIC-1431, University Hospital of Besançon, Besançon, France. chkim@chu-besancon.fr.|INSERM, Unit 1098, University of Franche-Comté, Besançon, France. chkim@chu-besancon.fr.
authors.forename: Stefano
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Medical Oncology, University Hospital of Besancon, 3 Boulevard Alexander Fleming, Besancon, F-25030, France. fredericfiteni@gmail.com.|Methodology and Quality of Life in Oncology Unit, University Hospital of Besançon, Besançon, France. fredericfiteni@gmail.com.
authors.forename: Frederic
authors.initials: F
authors.lastname: Fiteni
authors.affiliation: Methodology and Quality of Life in Oncology Unit, University Hospital of Besançon, Besançon, France. spaget@chu-besancon.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Paget-Bailly
authors.affiliation: Department of Oncology, Georges-Francois Leclerc Cancer Center, Dijon, France. FGhiringhelli@cgfl.fr.
authors.forename: François
authors.initials: F
authors.lastname: Ghiringhelli
authors.affiliation: Department of Digestive Surgery and Liver Transplantation, University Hospital of Besançon, Besançon, France. zaher.lakkis@gmail.com.
authors.forename: Zaher
authors.initials: Z
authors.lastname: Lakkis
authors.affiliation: Department of Medical Oncology, University Hospital of Besancon, 3 Boulevard Alexander Fleming, Besancon, F-25030, France. jary.marine@yahoo.fr.|INSERM, Unit 1098, University of Franche-Comté, Besançon, France. jary.marine@yahoo.fr.
authors.forename: Marine
authors.initials: M
authors.lastname: Jary
authors.affiliation: Department of Gastroenterology, University Hospital of Besançon, Besançon, France. ffein@chu-besancon.fr.
authors.forename: Francine
authors.initials: F
authors.lastname: Fein
authors.affiliation: Methodology and Quality of Life in Oncology Unit, University Hospital of Besançon, Besançon, France. franck.bonnetain@univ-fcomte.fr.|EA 3181 University of Franche-Comté, Besançon, Besançon, France. franck.bonnetain@univ-fcomte.fr.
authors.forename: Franck
authors.initials: F
authors.lastname: Bonnetain
authors.affiliation: Department of Digestive Surgery, Lille University Hospital, Lille, France. Christophe.mariette@chru-lille.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Mariette
authors.affiliation: Department of Medical Oncology, University Hospital of Besancon, 3 Boulevard Alexander Fleming, Besancon, F-25030, France. Christophe.borg@efs.sante.fr.|Clinical Investigational Centre, CIC-1431, University Hospital of Besançon, Besançon, France. Christophe.borg@efs.sante.fr.|INSERM, Unit 1098, University of Franche-Comté, Besançon, France. Christophe.borg@efs.sante.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Borg
mesh_terms: D000328:Adult; D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000188:drug therapy* / Q000401:mortality; D017024:Chemotherapy, Adjuvant; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality; D043823:Taxoids / Q000627:therapeutic use*
chemical_list: D043823:Taxoids