title: Enantioseparation of the Six Important Intermediates of Homoharringtonine With Immobilized Cellulose Chiral Stationary Phase.
abstract: A new liquid chromatographic method has been developed for the chiral separation of the enantiomers of intermediates in the preparation of the ester side-chain of homoharringtonine. The enantiomers were separated by a Chiralpak IC (250 × 4.6 mm, 5 µm) in normal phase high-performance liquid chromatography (HPLC). Four compounds were baseline resolved. By comparing the chromatographs of racemates and single enantiomers of the six intermediates, the enantiomeric excess values of the single enantiomers were evaluated, and the elution orders of the enantiomers were established.
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan, P.R. China.|Key Laboratory of State Ministry of Education for Pharmaceutical Technology, Zhengzhou, Henan, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan, P.R. China.
authors.forename: Qiuzheng
authors.initials: Q
authors.lastname: Du
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan, P.R. China.
authors.forename: Fang
authors.initials: F
authors.lastname: Sun
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan, P.R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan, P.R. China.|Key Laboratory of State Ministry of Education for Pharmaceutical Technology, Zhengzhou, Henan, P.R. China.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D006248:Harringtonines / Q000737:chemistry*; D000077863:Homoharringtonine; D013237:Stereoisomerism
chemical_list: D006248:Harringtonines; D000077863:Homoharringtonine; D002482:Cellulose
keywords: HPLC; chiralpak IC; e.e. values; enantiomeric separation; homoharringtonine