title: IFNA2: The prototypic human alpha interferon.
abstract: The human interferon α2 (IFNα2) was the first highly active IFN subtype to be cloned in the early eighties. It was also the first IFN and the first cytokine to be produced and commercialized by the pharmaceutical industry. Ipso facto it became the favorite IFNα subtype for academic researchers. For this fortunate reason IFNα2 has been at the origin of most discoveries related to the mechanism of action of type I interferons.
authors.affiliation: CNRS UMR 5235, University Montpellier, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
authors.forename: Franciane
authors.initials: F
authors.lastname: Paul
authors.affiliation: Institut Pasteur, 25 rue du Dr. Roux, 75015 Paris, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Pellegrini
authors.affiliation: CNRS UMR 5235, University Montpellier, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France. Electronic address: uze@univ-montp2.fr.
authors.forename: Gilles
authors.initials: G
authors.lastname: Uzé
mesh_terms: D000818:Animals; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D016898:Interferon-alpha / Q000737:chemistry / Q000502:physiology*; D011485:Protein Binding; D053633:Receptor, Interferon alpha-beta / Q000378:metabolism; D015398:Signal Transduction
chemical_list: C554158:IFNA2 protein, human; D016898:Interferon-alpha; D053633:Receptor, Interferon alpha-beta
keywords: Cytokine; Interferon α2; Type I interferon