title: Physical exercise versus fluoxetine: antagonistic effects on cortical spreading depression in Wistar rats.
abstract: The antidepressant fluoxetine and physical exercise exert similar effects on the serotoninergic system by increasing brain serotonin availability, and both show antagonistic action on cortical excitability. Here we provide the first assessment of the interaction of the two together on cortical spreading depression (CSD) in young adult rats. Wistar rats (40-60 days of life) received fluoxetine (10mg/kg/d, orogastrically) or an equivalent volume of water. Half of the animals from each condition were assigned to perform physical exercise in a treadmill, and the other half formed the sedentary (non-treadmill) control groups. Body parameters (Lee index and thoracic and abdominal circumferences) and the velocity of CSD propagation were investigated. Fluoxetine+exercise animals had less weight gain (78.68±3.19g) than either the fluoxetine-only (93.34±4.77g) or exercise-only group (97.04±3.48g), but body parameters did not differ among them. The velocity of CSD propagation was reduced in the fluoxetine-only and exercise-only groups compared to sedentary water controls (3.24±0.39mm/min). For the fluoxetine+exercise group, CSD velocity values were significantly lower (2.92±0.22mm/min) than for fluoxetine only (3.03±0.35mm/min); however, they were similar to values for the exercise-only group (2.96±0.23mm/min). These findings confirm the similar effects of fluoxetine and exercise and suggest a greater effect of physical exercise in reducing brain excitability.
authors.affiliation: Departamento de Nutrição, Universidade Federal de Pernambuco, Centro de Ciências da Saúde, 50670-901 Recife-PE, Brazil. Electronic address: helo-mcm@hotmail.com.
authors.forename: Heloísa
authors.initials: H
authors.lastname: Mirelle Costa Monteiro
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, Centro de Ciências Biológicas, 50740-600 Recife-PE, Brazil.
authors.forename: Nathália
authors.initials: N
authors.lastname: Lima Barreto-Silva
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, Centro de Ciências Biológicas, 50740-600 Recife-PE, Brazil.
authors.forename: Gracyelle
authors.initials: G
authors.lastname: Elizabete Dos Santos
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, Centro de Ciências Biológicas, 50740-600 Recife-PE, Brazil.
authors.forename: Amanda
authors.initials: A
authors.lastname: de Santana Santos
authors.affiliation: Departamento de Nutrição, Universidade Federal de Pernambuco, Centro de Ciências da Saúde, 50670-901 Recife-PE, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Séfora Bezerra Sousa
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, Centro de Ciências Biológicas, 50740-600 Recife-PE, Brazil. Electronic address: angela.asantos@yahoo.com.
authors.forename: Ângela
authors.initials: Â
authors.lastname: Amâncio-Dos-Santos
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D013181:Cortical Spreading Depression / Q000187:drug effects* / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005473:Fluoxetine
keywords: Body parameters; Brain excitability; Central nervous system; Treadmill