title: The relevance of the Renin-Angiotensin system in the development of drugs to combat preeclampsia.
abstract: Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5-8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called "a disease of theories." The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this review, we analyze the molecular mechanisms of preeclampsia with a particular focus on the pathogenesis of the hypertension in preeclampsia and its association with the renin-angiotensin system. In addition, we propose potential alternative strategies to target the renin-angiotensin system, which is enhanced during pregnancy.
authors.affiliation: Department of Diabetology and Endocrinology, Kanazawa Medical University, Ishikawa 920-0293, Japan ; Department of Obstetrics and Gynecology, Juntendo University, Tokyo 113-8431, Japan.
authors.forename: Norikazu
authors.identifier: 0000-0002-2024-2723
authors.initials: N
authors.lastname: Ueki
authors.affiliation: Department of Obstetrics and Gynecology, Juntendo University, Tokyo 113-8431, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Takeda
authors.affiliation: Department of Diabetology and Endocrinology, Kanazawa Medical University, Ishikawa 920-0293, Japan ; Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0293, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Koya
authors.affiliation: Department of Diabetology and Endocrinology, Kanazawa Medical University, Ishikawa 920-0293, Japan ; Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0293, Japan.
authors.forename: Keizo
authors.initials: K
authors.lastname: Kanasaki