title: Evaluation of prognostic factors after radical prostatectomy in pT3b prostate cancer patients in Japanese population.
abstract: OBJECTIVE
  The purpose of the current study was to evaluate prognostic factors after radical prostatectomy for prostate cancer patients with seminal vesicle invasion (pT3b) in the Japanese population.
  
  
  METHODS
  Between January 2005 and December 2011, 814 patients underwent radical prostatectomy without neoadjuvant hormonal therapy at our institutions. Among these patients, 31 were (3.8%) presented with pT3b. Kaplan-Meier method was used to determine biochemical recurrence-free, disease-specific and overall survival of patients in this group. Proportional hazards models were used to determine predictors of biochemical recurrence-free survival.
  
  
  RESULTS
  The median follow-up period was 60 months (range, 9-108 months). During follow-up, 23 patients (74.2%) experienced biochemical recurrence, and the overall 3-year probability of freedom from biochemical recurrence was 29%. However, only one patient died of the disease, and the 5-year overall survival was 92%. In multivariate analysis, age at the time of surgery was the only significant variable for predicting biochemical recurrence after radical prostatectomy (P = 0.0356, hazard ratio = 0.92, 95% confidence interval = 0.851-0.994).
  
  
  CONCLUSIONS
  Patients with seminal vesicle invasion of pathological specimens after radical prostatectomy have high biochemical recurrence, but the survival was favorable especially in light of current multimodal treatment regimens. However, patients with younger age at the time of surgery, in particular, should receive multimodal treatments to improve their outcome.
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto takahi@kuhp.kyoto-u.ac.jp.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Inoue
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Kinoshita
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto.
authors.forename: Naoki
authors.initials: N
authors.lastname: Terada
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kobayashi
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto.
authors.forename: Toshinari
authors.initials: T
authors.lastname: Yamasaki
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Matsui
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kamba
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Inui
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Motohiko
authors.initials: M
authors.lastname: Sugi
authors.affiliation: Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsuda
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Sakyoku, Kyoto.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012669:Seminal Vesicles / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen
keywords: biochemical recurrence; pT3b prostate cancer; prognostic factors