title: Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe.
abstract: Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.
authors.affiliation: Department Osnabrueck, Center for Radiotherapy Rheine-Osnabrueck, Osnabrueck, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Bölling
authors.affiliation: Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Braun-Munzinger
authors.affiliation: Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Burdach
authors.affiliation: Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Calaminus
authors.affiliation: Royal Victoria Infirmary, Newcastle, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Craft
authors.affiliation: Inserm U830, Laboratory of Genetics and Biology of Cancers, Institut Curie, Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Delattre
authors.affiliation: Université Paris-Sud, Le Kremlin-Bicêtre, and Gustave Roussy Institute, Villejuif, France.
authors.forename: M-C L
authors.initials: MC
authors.lastname: Deley
authors.affiliation: Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Dirksen
authors.affiliation: Zentrum für Pathologie Kempten-Allgäu, Kempten, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Dockhorn-Dworniczak
authors.affiliation: Department of Radiation Oncology, University of Luebeck and University Medical Center Schleswig-Holstein, Campus Luebeck, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Dunst
authors.affiliation: Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Engel
authors.affiliation: Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Faldum
authors.affiliation: Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Fröhlich
authors.affiliation: St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
authors.forename: H
authors.initials: H
authors.lastname: Gadner
authors.affiliation: Clinic of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, Duesseldorf, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Göbel
authors.affiliation: Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Gosheger
authors.affiliation: Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Hardes
authors.affiliation: Seattle Children's Hospital and Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Hawkins
authors.affiliation: Skåne University Hospital, Lund University, Lund, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Hjorth
authors.affiliation: Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Hoffmann
authors.affiliation: St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
authors.forename: H
authors.initials: H
authors.lastname: Kovar
authors.affiliation: Department of Paediatric Haematology and Oncology Charles University, 2nd School of Medicine, Prague, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Kruseova
authors.affiliation: St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
authors.forename: R
authors.initials: R
authors.lastname: Ladenstein
authors.affiliation: Kiel Paediatric Tumor Registry, Department of Paediatric Pathology, Christian-Albrechts-University Kiel, Kiel, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Leuschner
authors.affiliation: Alder Hey Children's National Health Service Foundation Trust, Liverpool, UK.
authors.forename: I J
authors.initials: IJ
authors.lastname: Lewis
authors.affiliation: Gustave Roussy Institute, Villejuif, France.
authors.forename: O
authors.initials: O
authors.lastname: Oberlin
authors.affiliation: Vestische Kinder-und Jugendklinik Datteln, Witten/Herdecke University, Datteln, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Paulussen
authors.affiliation: Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Potratz
authors.affiliation: Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Ranft
authors.affiliation: Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Rössig
authors.affiliation: Department of Radiotherapy and Radiation Oncology, Saarland University Medical Center, Homburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Rübe
authors.affiliation: Department of Radiation Therapy, University of Erlangen, Erlangen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Sauer
authors.affiliation: Department of Nuclear Medicine, University of Münster, Münster, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Schober
authors.affiliation: Department of Radiotherapy, University Hospital Muenster, Muenster, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Schuck
authors.affiliation: Clinic for Particle Therapy, West German Proton Therapy Center Essen, West German Cancer Center, University Hospital Essen.
authors.forename: B
authors.initials: B
authors.lastname: Timmermann
authors.affiliation: Inserm U830, Laboratory of Genetics and Biology of Cancers, Institut Curie, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Tirode
authors.affiliation: Emma Children Hospital AMC, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: van den Berg
authors.affiliation: Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany.
authors.forename: F
authors.initials: F
authors.lastname: van Valen
authors.affiliation: Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Vieth
authors.affiliation: Department of Radiotherapy, University Hospital Muenster, Muenster, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Willich
authors.affiliation: Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Winkelmann
authors.affiliation: NIHR University College London Hospitals Biomedical Research Centre, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Whelan
authors.affiliation: Department of Pediatrics, University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Womer
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D001859:Bone Neoplasms / Q000401:mortality / Q000628:therapy*; D002648:Child; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003299:Cooperative Behavior; D018450:Disease Progression; D006801:Humans; D033183:Interdisciplinary Communication; D020360:Neoadjuvant Therapy; D010027:Osteotomy; D018714:Radiotherapy, Adjuvant; D012512:Sarcoma, Ewing / Q000401:mortality / Q000628:therapy*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate