title: Interleukin-6 and C-reactive protein load in pre-storage and post-storage white blood cell-filtered red blood cell transfusions in premature infants.
abstract: OBJECTIVE
  Leukocyte contamination during blood transfusion can cause many adverse effects. Filtration can be performed either at bedside during the transfusion or as pre-storage filtration. Pre-storage filtration is superior to bedside filtration because leukocytes are removed prior to storage, thus preventing further adverse effects associated with the storage of these cells.
  
  
  METHODS
  One hundred and six infants were randomised into two groups: pre-storage filtration (group 1, n = 53) and bedside filtration (group 2, n = 53). C-reactive protein (CRP) and interleukin-6 (IL-6) levels were analysed within 24 h prior to the transfusion and 24 h after completion of the transfusion.
  
  
  RESULTS
  In group 1, pre-transfusion median CRP and IL-6 levels were 2·95 (0·73-10·25) mg L(-1) and 8·59 (3·45-20·55) pg L(-1) , respectively, and post-transfusion median CRP and IL-6 levels were 2·28 (0·44-12·87) mg L(-1) and 6·62 (2·18-27·87) pg L(-1) , respectively. In group 2, pre-transfusion median CRP and IL-6 levels were 1·30 (0·40-7·84) mg L(-1) and 4·40 (2-17·12) pg L(-1) , respectively, and post-transfusion median CRP and IL-6 levels were 3·50 (0·50-7·85) mg L(-1) and 8·30 (3·48-23·75) pg L(-1) , respectively. There were no differences between pre-storage and post-storage leukoreduction average IL-6 and CRP levels in either group (P > 0·05 for both). Packed red blood cell (PRBC)-related necrotizing enterocolitis was detected in one infant in group 2.
  
  
  CONCLUSIONS
  Because leukocytes in PRBC transfusions can be associated with many undesirable effects, leukoreduction is the best choice to prevent those effects. However, this method is still controversial. We demonstrated that using pre-storage and post-storage leukoreduction methods in erythrocyte transfusions did not change CRP or IL-6 levels, which are indicators of acute-phase response.
authors.affiliation: Division of Neonatology, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Say
authors.affiliation: Division of Neonatology, Ankara, Turkey.
authors.forename: F N
authors.initials: FN
authors.lastname: Sari
authors.affiliation: Division of Neonatology, Ankara, Turkey.
authors.forename: S S
authors.initials: SS
authors.lastname: Oguz
authors.affiliation: Division of Neonatology, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Degirmencioglu
authors.affiliation: Division of Neonatology, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Arayici
authors.affiliation: Division of Neonatology, Ankara, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Kadioglu Simsek
authors.affiliation: Blood Center, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
authors.forename: E G
authors.initials: EG
authors.lastname: Ibrisim
authors.affiliation: Division of Neonatology, Ankara, Turkey.|Department of Pediatrics, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.
authors.forename: U
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D001793:Blood Preservation; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015850:Interleukin-6 / Q000032:analysis* / Q000097:blood; D047589:Leukocyte Reduction Procedures; D008297:Male; D011897:Random Allocation
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D002097:C-Reactive Protein
keywords: acute-phase reactant; leukoreduction; newborn; red blood cell transfusion