title: Rare SNP rs12731181 in the miR-590-3p Target Site of the Prostaglandin F2α Receptor Gene Confers Risk for Essential Hypertension in the Han Chinese Population.
abstract: OBJECTIVE
  To investigate whether rs12731181 (A→G) interrupted miR-590-3p-mediated suppression of the prostaglandin F2α receptor (FP) and whether it is associated with essential hypertension in the Chinese population.
  
  
  RESULTS
  We found that miR-590-3p regulates human FP gene expression by binding to its 3'-untranslated region. rs12731181 (A→G) altered the binding affinity between miR-590-3p and its FP 3'-untranslated region target, thus reducing the suppression of FP expression, which, in turn, enhanced FP receptor-mediated contractility of vascular smooth muscle cells. Overexpression of FP augmented vascular tone and elevated blood pressure in mice. An association study was performed to analyze the relationship between the FP gene and essential hypertension in the Han Chinese population. The results indicated that the rs12731181 G allele was associated with susceptibility to essential hypertension. Carriers of the AG genotype exhibited significantly higher blood pressure than those of the AA genotype. FP gene expression was significantly higher in human peripheral leukocytes from individuals with the AG genotype than that in leukocytes from individuals with the AA genotype.
  
  
  CONCLUSIONS
  rs12731181 in the seed region of the miR-590-3p target site is associated with increased risk of essential hypertension and represents a new paradigm for FP involvement in blood pressure regulation.
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Bing
authors.initials: B
authors.lastname: Xiao
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Shui-Ming
authors.initials: SM
authors.lastname: Gu
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Mulin Jun
authors.initials: MJ
authors.lastname: Li
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Bo
authors.initials: B
authors.lastname: Tao
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Yuanyang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Shengkai
authors.initials: S
authors.lastname: Zuo
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Yujun
authors.initials: Y
authors.lastname: Shen
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Yu
authors.initials: Y
authors.lastname: Yu
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Di
authors.initials: D
authors.lastname: Chen
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Guilin
authors.initials: G
authors.lastname: Chen
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Deping
authors.initials: D
authors.lastname: Kong
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Juan
authors.initials: J
authors.lastname: Tang
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Dong-Rui
authors.initials: DR
authors.lastname: Chen
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Sara
authors.initials: S
authors.lastname: Alberti
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Melania
authors.initials: M
authors.lastname: Dovizio
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Raffaele
authors.initials: R
authors.lastname: Landolfi
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Luciana
authors.initials: L
authors.lastname: Mucci
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Pei-Zhi
authors.initials: PZ
authors.lastname: Miao
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Pingjin
authors.initials: P
authors.lastname: Gao
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Ding-Liang
authors.initials: DL
authors.lastname: Zhu
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Junwen
authors.initials: J
authors.lastname: Wang
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.).
authors.forename: Paola
authors.initials: P
authors.lastname: Patrignani
authors.affiliation: From the Key Laboratory of Food Safety Research (B.X., Y.W., S.Z., Y.S., Yu Yu, D.C., G.C., D.K., J.T., Q.L., Ying Yu), Key Laboratory of Nutrition and Metabolism (Y.L.), Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology, Shanghai Xuhui Central Hospital, Shanghai, China (S.-M.G., P.-Z.M.); Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China (M.J.L., J.W.); Shenzhen Institute of Research & Innovation, The University of Hong Kong, Shenzhen, China (J.W.); Orthopedic Institute, Soochow University, Jiangsu, China (J.L., B.L.); College of Basic Medicine, Gannan Medical University, Ganzhou, China (B.T.); Shanghai Key Laboratory of Vascular Biology and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Y.W., D.-R.C., P.G., D.-L.Z.); Department of Neuroscience, Imaging and Clinical Sciences and CeSI, "G. d'Annunzio" University, Chieti, Italy (S.A., M.D., P.P.); Department of Medical Science, Catholic University, Rome, Italy (R.L., L.M.); Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China (Ying Yu); and State Key Laboratory for Medical Genomics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, China (B.X.). yuying@sibs.ac.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yu
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D044466:Asian People / Q000235:genetics*; D001665:Binding Sites; D002681:China / Q000208:ethnology; D000075222:Essential Hypertension; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011982:Receptors, Prostaglandin / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D020413:3' Untranslated Regions; C568221:MIRN590 microRNA, human; D035683:MicroRNAs; D011982:Receptors, Prostaglandin; C034671:prostaglandin F2alpha receptor
keywords: essential; hypertension; microRNAs; polymorphism; prostaglandin F2α receptor; single nucleotide