title: Comparative study of combined bevacizumab/targeted photocoagulation vs bevacizumab alone for macular oedema in ischaemic branch retinal vein occlusions.
abstract: OBJECTIVE
  To investigate whether targeted retinal photocoagulation (TRP) of peripheral non-perfused areas (NPAs) could prevent the recurrence of macular oedema (ME) due to branch retinal vein occlusion (BRVO) after intravitreal bevacizumab injection (IVB).
  
  
  METHODS
  Eyes received 1.25 mg IVB only (IVB group) or combined with TRP (IVB + TRP group) of NPAs, more than 5 disc areas identified by fluorescein angiography in the patients with ME secondary to BRVO. Best-corrected visual acuity (BCVA) and central retinal thickness (CRT) determined by optical coherence tomography were measured every month for 6 months.
  
  
  RESULTS
  Thirty-eight patients were enrolled and randomized to IVB group (n = 19) and IVB + TRP group (n = 19). Both groups showed similar thinning in CRT at 1 week after IVB, IVB + TRP group maintained thinner retina at 2 (p = 0.0072) and 3 (p = 0.0086) months compared with IVB group in whom turned to thickened almost back to baseline at 3 months. The number of reinjections in IVB group (1.58 ± 0.69) was significantly greater (p = 0.0025) than that in IVB + TRP group (0.83 ± 0.62). BCVA significantly improved at 6 month in IVB + TRP group (p = 0.015), but not in IVB group.
  
  
  CONCLUSIONS
  TRP of NPAs reduced the amount of ME recurrence following IVB compared to IVB alone.
authors.affiliation: Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Yoshida-Gun, Fukui-Ken, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tomomatsu
authors.affiliation: Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Yoshida-Gun, Fukui-Ken, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tomomatsu
authors.affiliation: Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Yoshida-Gun, Fukui-Ken, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takamura
authors.affiliation: Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Yoshida-Gun, Fukui-Ken, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Gozawa
authors.affiliation: Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Yoshida-Gun, Fukui-Ken, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Arimura
authors.affiliation: Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Yoshida-Gun, Fukui-Ken, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takihara
authors.affiliation: Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Yoshida-Gun, Fukui-Ken, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Inatani
mesh_terms: D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000068258:Bevacizumab / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D058449:Intravitreal Injections; D007511:Ischemia / Q000188:drug therapy*; D017075:Laser Coagulation; D008269:Macular Edema / Q000188:drug therapy / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012170:Retinal Vein Occlusion / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity / Q000502:physiology
chemical_list: D020533:Angiogenesis Inhibitors; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab
keywords: best-corrected visual acuity; bevacizumab; branch retinal vein occlusion; central retinal thickness; fluorescein angiography; macular oedema; non-perfused areas; photocoagulation; vascular endothelial growth factor