title: [Estimation of hospitalization rate of laboratory confirmed influenza cases in Jingzhou city, Hubei province, 2010-2012].
abstract: OBJECTIVE
  To estimate the hospitalization rate of severe acute respiratory infection (SARI) cases attributable to influenza in Jingzhou city, Hubei province from 2010 to 2012.
  
  
  METHODS
  SARI surveillance was conducted at four hospitals in Jingzhou city, Hubei province from 2010 to 2012. Inpatients meeting the SARI case definition and with informed consent were enrolled to collect their demographic information, clinical features, treatment, and disease outcomes, with their respiratory tract specimens collected for PCR test of influenza virus.
  
  
  RESULTS
  From April, 2010 to September, 2012, 19 679 SARI cases enrolled were residents of Jingzhou, and nasopharyngeal swab was collected from 18 412 (93.6%) cases of them to test influenza virus and 13.3% were positive for influenza. During the three consecutive 2010-2012 flu seasons, laboratory-confirmed influenza was associated with 102 per 100 000, 132 per 100 000 and 244 per 100 000, respectively. As for the hospitalization rate attributable to specific type/subtype of influenza virus, 48 per 100 000, 30 per 100 000 and 24 per 100 000 were attributable to A (H3N2), A (H1N1) pdm2009, and influenza B, respectively in 2010-2011 season; 42 per 100 000 [A (H3N2)] and 90 per 100 000 (influenza B) in 2011-2012 season; 90 per 100 000 [A (H3N2)] and one per 100 000 [influenza B] from April, 2010 to September, 2012. SARI hospitalization caused by influenza A or B occurred both mainly among children younger than five years old, with the peak in children aged 0.5 year old.
  
  
  CONCLUSIONS
  Influenza could cause a substantial number of hospitalizations and different viral type/subtype result in different hospitalizations over influenza seasons in Jingzhou city, Hubei province. Children less than five years old should be prioritized for influenza vaccination in China.
authors.affiliation: Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Jingzhou Center for Disease Control and Prevention.
authors.forename: Maoyi
authors.initials: M
authors.lastname: Chen
authors.affiliation: China-United States Collaborative Program on Emerging and Re-emerging Infectious Diseases, United States Center for Disease Control and Prevention.
authors.forename: Yang
authors.initials: Y
authors.lastname: Huai
authors.affiliation: Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention.
authors.forename: Xuesen
authors.initials: X
authors.lastname: Xing
authors.affiliation: Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Peng
authors.affiliation: Public Health Emergency Center, Chinese Center for Disease Control and Prevention.
authors.forename: Nijuan
authors.initials: N
authors.lastname: Xiang
authors.affiliation: China-United States Collaborative Program on Emerging and Re-emerging Infectious Diseases, United States Center for Disease Control and Prevention.
authors.forename: Yuzhi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention.
authors.forename: Linlin
authors.initials: L
authors.lastname: Liu
authors.affiliation: Jingzhou Center for Disease Control and Prevention.
authors.forename: Jigui
authors.initials: J
authors.lastname: Huang
authors.affiliation: Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Luzhao
authors.initials: L
authors.lastname: Feng
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention.
authors.forename: Xuhua
authors.initials: X
authors.lastname: Guan
authors.affiliation: China-United States Collaborative Program on Emerging and Re-emerging Infectious Diseases, United States Center for Disease Control and Prevention.
authors.forename: John
authors.initials: J
authors.lastname: Klena
authors.affiliation: Hubei Provincial Center for Disease Control and Prevention.
authors.forename: Faxian
authors.initials: F
authors.lastname: Zhan
authors.affiliation: Division of Infectious Disease, Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Email: yuhj@chinacdc.cn.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Yu
mesh_terms: D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003710:Demography; D006760:Hospitalization; D006761:Hospitals; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype; D053122:Influenza A Virus, H3N2 Subtype; D007251:Influenza, Human / Q000453:epidemiology*; D007297:Inpatients; D007753:Laboratories; D009975:Orthomyxoviridae; D016133:Polymerase Chain Reaction; D012141:Respiratory Tract Infections; D012621:Seasons; D014611:Vaccination