title: The Effects of Oxygen Therapy on Myocardial Salvage in ST Elevation Myocardial Infarction Treated with Acute Percutaneous Coronary Intervention: The Supplemental Oxygen in Catheterized Coronary Emergency Reperfusion (SOCCER) Study.
abstract: OBJECTIVE
  Despite a lack of scientific evidence, oxygen has long been a part of standard treatment for patients with acute myocardial infarction (AMI). However, several studies suggest that oxygen therapy may have negative cardiovascular effects. We here describe a randomized controlled trial, i.e. Supplemental Oxygen in Catheterized Coronary Emergency Reperfusion (SOCCER), aiming to evaluate the effect of oxygen therapy on myocardial salvage and infarct size in patients with ST elevation myocardial infarction (STEMI) treated with a primary percutaneous coronary intervention (PCI).
  
  
  METHODS
  One hundred normoxic STEMI patients accepted for a primary PCI are randomized in the ambulance to either standard oxygen therapy or no supplemental oxygen. All patients undergo cardiovascular magnetic resonance imaging (CMR) 2-6 days after the primary PCI, and a subgroup of 50 patients undergo an extended echocardiography during admission and at 6 months. All patients are followed for 6 months for hospital admission for heart failure and subjective perception of health. The primary endpoint is the myocardial salvage index on CMR.
  
  
  CONCLUSIONS
  Even though oxygen therapy is a part of standard care, oxygen may not be beneficial for patients with AMI and is possibly even harmful. The results of the present and concurrent oxygen trials may change international treatment guidelines for patients with AMI or ischemia.
authors.affiliation: Section of Emergency Medicine, Clinical Sciences Lund, Lund University, Lund, Sweden.
authors.forename: Ardavan
authors.initials: A
authors.lastname: Khoshnood
authors.forename: Marcus
authors.initials: M
authors.lastname: Carlsson
authors.forename: Mahin
authors.initials: M
authors.lastname: Akbarzadeh
authors.forename: Pallonji
authors.initials: P
authors.lastname: Bhiladvala
authors.forename: Anders
authors.initials: A
authors.lastname: Roijer
authors.forename: Stefan
authors.initials: S
authors.lastname: Bodetoft
authors.forename: Peter
authors.initials: P
authors.lastname: Höglund
authors.forename: David
authors.initials: D
authors.lastname: Zughaft
authors.forename: Lizbet
authors.initials: L
authors.lastname: Todorova
authors.forename: David
authors.initials: D
authors.lastname: Erlinge
authors.forename: Ulf
authors.initials: U
authors.lastname: Ekelund
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D004562:Electrocardiography; D004630:Emergencies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009203:Myocardial Infarction / Q000628:therapy*; D009206:Myocardium / Q000473:pathology*; D010100:Oxygen / Q000627:therapeutic use*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*
chemical_list: D010100:Oxygen