title: [Resistance of clinical strains of pathogenic E. coli to antibiotics and bacteriophage in hospitalized children with escherichiosis in St. Petersburg].
abstract: The data on the resistance frequency of the diarrheagenic E. coli isolates to antibacterial agents and a specific bacteriophage are presented. The strains were isolated from hospitalized children in St. Petersburg in 2011-2013 and belonged to three groups, i.e. enteropathogenic (EPE), enterotoxigenic (ETE) and enteroinvasine (EIE). It was shown that in the children aged from 1 month to 18 years the average antibiotic resistance was maximum in the EIE isolates and decreased in the following order: EIE (15.2%), EPE (6.0%), ETE (3.3%). The clinical EIE isolates showed no resistance to the new generation cephalosporins (cefuroxime, cephepime) and nitrofurans. The E. coli isolates of the three groups were characterized by high resistance to a specific bacteriophage which decreased in the following order: ETE (44.8%), EIE (37.0%), EPE (28.8%). The multiple resistance of the diarrheagenic E. coli isolates of the three groups to the antibacterials averaged 2.8%. The maximum frequency of resistance of the clinical isolates of the three groups to nalidixic acid was observed: EIE - 28.6%, EPE - 26.3%, ETE - 9.1%. The results of the study may be useful in the tactics of therapy of diarrheagenic E. coli infection in children.
authors.forename: N V
authors.initials: NV
authors.lastname: Gonchar
authors.forename: I V
authors.initials: IV
authors.lastname: Partina
authors.forename: O I
authors.initials: OI
authors.lastname: Nyrkova
authors.forename: A S
authors.initials: AS
authors.lastname: Drap
mesh_terms: D000293:Adolescent; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000494:pharmacology; D003090:Coliphages / Q000502:physiology*; D024881:Drug Resistance, Bacterial; D054308:Enteropathogenic Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000821:virology; D054307:Enterotoxigenic Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000821:virology; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000821:virology; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D009581:Nitrofurans / Q000494:pharmacology; D012426:Russia
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D009581:Nitrofurans; D002701:Chloramphenicol