title: Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment.
abstract: Somatic action potentials (AP) of cortical pyramidal neurons have characteristically high onset-rapidness. The onset of the AP waveform is an indirect measure for the ability of a neuron to respond to temporally fast-changing stimuli. Theoretical studies on the pyramidal neuron response usually involves a canonical Hodgkin-Huxley (HH) type ion channel gating model, which assumes statistically independent gating of each individual channel. However, cooperative activity of ion channels are observed for various cell types, meaning that the activity (e.g. opening) of one channel triggers the activity (e.g. opening) of a certain fraction of its neighbors and hence, these groups of channels behave as a unit. In this study, we describe a multi-compartmental conductance-based model with cooperatively gating voltage-gated Na channels in the axon initial segment. Our model successfully reproduced the somatic sharp AP onsets of cortical pyramidal neurons. The onset latencies from the initiation site to the soma and the conduction velocities were also in agreement with the previous experimental studies.
authors.affiliation: Department of Molecular Biology and Genetics, Üsküdar University, Istanbul, Turkey, poz.neuro@gmail.com.
authors.forename: Pinar
authors.initials: P
authors.lastname: Öz
authors.forename: Min
authors.initials: M
authors.lastname: Huang
authors.forename: Fred
authors.initials: F
authors.lastname: Wolf
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology*; D004558:Electric Stimulation; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D015222:Sodium Channels / Q000502:physiology*
chemical_list: D015222:Sodium Channels