title: [Surgical excision and botulinum toxin A injection for vocal process granuloma].
abstract: OBJECTIVE
  To study the efficacy of treatment with microsurgery in combination with local injection of type A botulinum toxin for vocal process granuloma.
  
  
  METHODS
  28 patients with vocal process granuloma received endotracheal intubation under general anesthesia. The lesion was removed with micro-scissor and CO2 laster under a self-retaining laryngoscope and microscope. The incision and mucous membrane surrounding the wound was closed with 8-0 absorbable suture. 4-point injection of botulinum toxin type A 8-15 u was then performed along the thyroarytenoid muscle and arytenoid muscle of the same side. Postoperative medication was administered based on disease causes.
  
  
  RESULTS
  All patients experienced vocal cord dyskinesia of the injected side 2-3 days after surgery. At 1 month after the surgery, wound healing was good in all the 28 patients, and the vocal cord movement was limited at the injected side. At 3 months, movement of the bilateral vocal cords was normal, and the vocal cord process mucosa was smooth. Patients were followed up for more than a year, and only one patient had recurrence in 2 months after surgery. The cure rate was 96. 4%.
  
  
  CONCLUSIONS
  Combination of laryngeal microsurgery and type A botulinum toxin local injection can shorten the treatment course of vocal process granuloma.
authors.forename: Lijing
authors.initials: L
authors.lastname: Ma
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiao
authors.forename: Jingying
authors.initials: J
authors.lastname: Ye
authors.forename: Qingwen
authors.initials: Q
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000768:Anesthesia, General; D001905:Botulinum Toxins / Q000008:administration & dosage*; D006099:Granuloma / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007267:Injections; D007442:Intubation, Intratracheal; D007820:Laryngeal Mucosa; D007821:Laryngeal Muscles; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000601:surgery*; D020704:Laryngoscopes; D007830:Larynx; D008866:Microsurgery; D011184:Postoperative Period; D012008:Recurrence; D014827:Vocal Cords; D014945:Wound Healing
chemical_list: D001905:Botulinum Toxins