title: Association of Choroidal Neovascularization and Central Serous Chorioretinopathy With Optical Coherence Tomography Angiography.
abstract: OBJECTIVE
  Choroidal neovascularization (CNV) is a major cause of vision loss in chronic central serous chorioretinopathy (CSCR). Detecting CNV using fluorescein angiography (FA) may be challenging owing to the coexistence of features related to the primary diagnosis of CSCR. Optical coherence tomography angiography (OCTA) allows noninvasive visualization of retinal and choroidal vasculature via motion contrast and may contribute to the unequivocal diagnosis of CNV in this population.
  
  
  OBJECTIVE
  To evaluate the sensitivity of spectral-domain OCTA in detecting CNV associated with chronic CSCR.
  
  
  METHODS
  Observational cross-sectional study including 23 patients (27 eyes) who presented at the New England Eye Center between August 1, 2014, and November 30, 2014, with suspected CNV complicating chronic CSCR and underwent standard assessment for CNV diagnosis, including FA imaging. Participants were prospectively recruited to receive imaging tests using prototype OCTA software on a commercially available spectral-domain OCT. Orthogonal registration and the merging of 2 consecutive image sets were used to obtain 3 × 3-mm and 6 × 6-mm OCT angiograms centered at the macula. Two independent readers masked to other imaging findings performed a qualitative analysis on OCTA depictions of vascular flow representing CNV and the morphologic appearance of CNV.
  
  
  METHODS
  Choroidal neovascularization location as well as retinal pigment epithelial detachment internal reflectivity and the presence of subretinal and intraretinal fluid. Sensitivity and specificity of OCTA in detecting CNV were estimated using FA as the standard examination reference.
  
  
  RESULTS
  Choroidal neovascularization was diagnosed in 8 of 27 eyes (30%) based on FA imaging analysis. Optical coherence tomography angiography and corresponding OCT B-scans detected 100% (8 of 8) of these CNV lesions and correctly excluded 100% (19 of 19) of eyes with CSCR without CNV. Sensitivity was 100% (95% CI, 0.62-1) and specificity was 100% (95% CI, 0.82-1). Morphologic appearance, location, and position of the CNV relative to the retinal pigment epithelium and Bruch membrane were described using OCTA that combined flow and structural information.
  
  
  CONCLUSIONS
  This study suggests that OCT alone (OCTA and coregistered OCT B-scans) features sensitivity and specificity comparable with FA for the detection of CNV in eyes with chronic CSCR.
authors.affiliation: New England Eye Center at Tufts Medical Center, Boston, Massachusetts2Tufts University, Boston, Massachusetts3Capes Foundation, Ministry of Education of Brazil, Brasília, Distrito Federal, Brazil.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Bonini Filho
authors.affiliation: New England Eye Center at Tufts Medical Center, Boston, Massachusetts4Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge.
authors.forename: Talisa E
authors.initials: TE
authors.lastname: de Carlo
authors.affiliation: New England Eye Center at Tufts Medical Center, Boston, Massachusetts.
authors.forename: Daniela
authors.initials: D
authors.lastname: Ferrara
authors.affiliation: New England Eye Center at Tufts Medical Center, Boston, Massachusetts.
authors.forename: Mehreen
authors.initials: M
authors.lastname: Adhi
authors.affiliation: New England Eye Center at Tufts Medical Center, Boston, Massachusetts.
authors.forename: Caroline R
authors.initials: CR
authors.lastname: Baumal
authors.affiliation: New England Eye Center at Tufts Medical Center, Boston, Massachusetts.
authors.forename: Andre J
authors.initials: AJ
authors.lastname: Witkin
authors.affiliation: New England Eye Center at Tufts Medical Center, Boston, Massachusetts.
authors.forename: Elias
authors.initials: E
authors.lastname: Reichel
authors.affiliation: New England Eye Center at Tufts Medical Center, Boston, Massachusetts.
authors.forename: Jay S
authors.initials: JS
authors.lastname: Duker
authors.affiliation: New England Eye Center at Tufts Medical Center, Boston, Massachusetts.
authors.forename: Nadia K
authors.initials: NK
authors.lastname: Waheed
mesh_terms: D000328:Adult; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000503:physiopathology; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012163:Retinal Detachment / Q000175:diagnosis; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology