title: ALK-negative anaplastic large cell lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2.
authors.affiliation: Department of Clinical Pathology, VU University Medical Center, Amsterdam sagm.cillessen@vumc.nl.
authors.forename: Saskia A G M
authors.initials: SA
authors.lastname: Cillessen
authors.affiliation: Department of Clinical Pathology, VU University Medical Center, Amsterdam.
authors.forename: Nathalie J
authors.initials: NJ
authors.lastname: Hijmering
authors.affiliation: Department of Clinical Pathology, VU University Medical Center, Amsterdam.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Moesbergen
authors.affiliation: Department of Clinical Pathology, VU University Medical Center, Amsterdam.
authors.forename: Wim
authors.initials: W
authors.lastname: Vos
authors.affiliation: Department of Rheumatology, VU University Medical Center, Amsterdam.
authors.forename: Sue Ellen
authors.initials: SE
authors.lastname: Verbrugge
authors.affiliation: Department of Rheumatology, VU University Medical Center, Amsterdam.
authors.forename: Gerrit
authors.initials: G
authors.lastname: Jansen
authors.affiliation: Department of Hematology, VU University Medical Center, Amsterdam.
authors.forename: Otto J
authors.initials: OJ
authors.lastname: Visser
authors.affiliation: Department of Clinical Pathology, VU University Medical Center, Amsterdam Department of Pathology, Diakonessenhuis, Utrecht, The Netherlands.
authors.forename: Joost J
authors.initials: JJ
authors.lastname: Oudejans
authors.affiliation: Department of Clinical Pathology, VU University Medical Center, Amsterdam.
authors.forename: Chris J L M
authors.initials: CJ
authors.lastname: Meijer
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D000069286:Bortezomib / Q000494:pharmacology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D008297:Male; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D020794:Receptor Protein-Tyrosine Kinases; D014407:Tumor Cells, Cultured; D015854:Up-Regulation / Q000187:drug effects*; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis*
chemical_list: C494826:BAX protein, human; C000595707:BCL2 protein, human; C498702:PMAIP1 protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D000069286:Bortezomib; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: Bcl-2; Noxa; anaplastic large cell lymphoma; apoptosis; bortezomib; chemotherapy-resistance