title: Anticancer, photoluminescence and electrochemical properties of structurally characterized two imine derivatives.
abstract: Two imine compounds, 4-[(E)-(2-methoxybenzylidene)amino]phenol (L(1)) and 4-[(E)-(3,4-dimethoxybenzylidene)amino]phenol (L(2)) were synthesized and characterized by the analytical and spectroscopic methods. The electrochemical and photoluminescence properties of the imine compounds L(1) and L(2) were investigated in different solvents. The compounds L(1) and L(2) show different redox processes at some potentials. The molecular structures of two Schiff base compounds are broadly similar, differing principally in the position, the number of methoxy (-OCH3) groups and dihedral angles between aromatic rings. While the compound L(1) has only one methoxy group located on the o-position with respect to the imine bond (C=N), the L(2) contains two methoxy groups on the p-m-positions with respect to the imine bond. The imine compounds show two or three emission bands in the 619-832 nm range in organic solvents. In the 1.0×10(-3) M concentration, the compounds have the highest excitation and emission bands. The imine compounds L(1) and L(2) were screened for their in vitro cytotoxicity on HeLa cell lines using the xCELLigence system (Real Time Cell Analyzer).
authors.affiliation: Chemistry Department, K.Maras Sütcü Imam University, 46100 K.Maras, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Ceyhan
authors.affiliation: Chemistry Department, K.Maras Sütcü Imam University, 46100 K.Maras, Turkey.
authors.forename: Muhammet
authors.initials: M
authors.lastname: Köse
authors.affiliation: Chemistry Department, K.Maras Sütcü Imam University, 46100 K.Maras, Turkey. Electronic address: mtumer@ksu.edu.tr.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tümer
authors.affiliation: Chemistry Department, Çankırı Karatekin University, 18100 Çankırı, Turkey.
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Demirtaş
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D055664:Electrochemical Techniques / Q000379:methods*; D006367:HeLa Cells; D006801:Humans; D006860:Hydrogen Bonding; D007097:Imines / Q000737:chemistry* / Q000494:pharmacology*; D049449:Luminescence; D008968:Molecular Conformation; D066244:Proton Magnetic Resonance Spectroscopy; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D007097:Imines; D012997:Solvents
keywords: Anticancer; Electrochemistry; Photoluminescence; Schiff base