title: Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients.
abstract: BACKGROUND
  This study aimed to analyze the characteristics of HBsAg, HBsAb, coexistence of HBsAg and HBsAb, and the genotypic distribution of HBV in Chinese schizophrenia patients.
  
  
  METHODS
  A total of 1,694 schizophrenia patients, 9-85 years of age, were recruited for the present study. HBsAg, HBsAb, and HBV DNA were detected with commercial methods. ALT, AST, γ-GT, TBIL, and IBIL were measured by an automatic biochemistry analyzer. All statistical analyses were performed with SPSS 13.0.
  
  
  RESULTS
  The seroprevalence of HBsAg and HBsAb in 1,649 schizophrenia patients was 11.0% and 54.6%, respectively. HBsAb seroprevalence significantly decreased with the duration of the disease (p = 0.0009). The lowest seroprevalence of HBsAg was determined in 9.4% of the patients who had had the illness for < 1 year, and then increased to 11.7%, 11.3% and 11.7% in the patients who had had the illness for 1-5 years, 6-10 years and > 10 years. HBsAg and HBsAb coexisted in 69 individuals, which comprised 4.2% of the total subjects, and in 38.1% of the HBsAg-positive patients. Additionally, HBV titers were quantified in 64 HBsAg-positive samples; the highest virus titer was 6.14×108 copies/mL, while 12 patients had less than 500 copies/mL. Moreover, among 48 HBV strains isolated from 62 HBsAg-positive samples, 33 and 15 strains belonged to genotypes C and B, respectively.
  
  
  CONCLUSIONS
  Genotypes B and C HBV were the dominant genotypes distributed in schizophrenia patients, and the HBsAb seroprevalence significantly decreased with illness duration. Effective prevention strategies for against HBV transmission are required.
authors.affiliation: SSchool of Public Health, Jiangsu Key Laboratory and Translational Medicine for Geriatric Disease, Medical College of Soochow University, Suzhou, Jiangsu, China. zhuhuijuansd@suda.edu.cn.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Zhu
authors.forename: Xingxiang
authors.initials: X
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Xue
authors.forename: Chong
authors.initials: C
authors.lastname: Shen
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Li
authors.forename: Aili
authors.initials: A
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zheng
authors.forename: Chen
authors.initials: C
authors.lastname: Dong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D004798:Enzymes / Q000097:blood; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications*; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D004798:Enzymes; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens