title: An expression system for Gustatory receptors - and why it failed.
abstract: A recent paper by the Dahankuar laboratory suggested that single Drosophila sugar receptors proteins accurately mediate sugar detection when ectopically expressed in olfactory neurons of the antenna. These findings contra-dict numerous previously published electrophysiological and behavioral investigations, which all point towards heteromultimeric sugar taste receptors. Here, I provide some explanation why this "pseudo-heterologous" expression system may have led to this misleading conclusion.
authors.affiliation: a Department of Molecular and Cellular Medicine ; Texas A&M Health Science Center; College Station , TX USA.
authors.forename: Hubert
authors.initials: H
authors.lastname: Amrein
mesh_terms: D000818:Animals; D004330:Drosophila / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D013649:Taste; D013650:Taste Buds / Q000502:physiology*
chemical_list: D011956:Receptors, Cell Surface
keywords: Gr Genes; expression system; heterodimers; olfactony learning and memory; olfactory neuron; taste receptors