title: Cytoplasmic dynein and early endosome transport.
abstract: Microtubule-based distribution of organelles/vesicles is crucial for the function of many types of eukaryotic cells and the molecular motor cytoplasmic dynein is required for transporting a variety of cellular cargos toward the microtubule minus ends. Early endosomes represent a major cargo of dynein in filamentous fungi, and dynein regulators such as LIS1 and the dynactin complex are both required for early endosome movement. In fungal hyphae, kinesin-3 and dynein drive bi-directional movements of early endosomes. Dynein accumulates at microtubule plus ends; this accumulation depends on kinesin-1 and dynactin, and it is important for early endosome movements towards the microtubule minus ends. The physical interaction between dynein and early endosome requires the dynactin complex, and in particular, its p25 component. The FTS-Hook-FHIP (FHF) complex links dynein-dynactin to early endosomes, and within the FHF complex, Hook interacts with dynein-dynactin, and Hook-early endosome interaction depends on FHIP and FTS.
authors.affiliation: Department of Biochemistry and Molecular Biology, F. Edward Hébert School of Medicine, The Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA, xin.xiang@usuhs.edu.
authors.forename: Xin
authors.initials: X
authors.lastname: Xiang
authors.forename: Rongde
authors.initials: R
authors.lastname: Qiu
authors.forename: Xuanli
authors.initials: X
authors.lastname: Yao
authors.forename: Herbert N
authors.initials: HN
authors.lastname: Arst
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Peñalva
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D001692:Biological Transport / Q000502:physiology; D003593:Cytoplasm / Q000378:metabolism*; D004398:Dyneins / Q000235:genetics / Q000378:metabolism*; D011992:Endosomes / Q000378:metabolism*; D005658:Fungi / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological
chemical_list: D004398:Dyneins