title: Targeting drug sensitivity predictors: New potential strategies to improve pharmacotherapy of human brain disorders.
abstract: One of the main challenges in medicine is the lack of efficient drug therapies for common human disorders. For example, although depressed patients receive powerful antidepressants, many often remain resistant to psychopharmacotherapy. The growing recognition of complex interplay between the drug targets and the predictors of drug sensitivity requires an improved understanding of these two key aspects of drug action and their potentially shared molecular networks. Here, we apply the concept of endophenotypes and their interplay to drug action and sensitivity. Based on these analyses, we postulate that novel drugs may be developed by targeting specific molecular pathways that integrate drug targets with drug sensitivity predictors.
authors.affiliation: Research Institute for Marine Drugs and Nutrition, College for Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong 524025, China; ZENEREI Institute, 309 Palmer Court, Slidell, LA 70458, USA; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, 199034, Russia. Electronic address: avkalueff@gmail.com.
authors.forename: Allan V
authors.initials: AV
authors.lastname: Kalueff
authors.affiliation: ZENEREI Institute, 309 Palmer Court, Slidell, LA 70458, USA.
authors.forename: Adam Michael
authors.initials: AM
authors.lastname: Stewart
authors.affiliation: ZENEREI Institute, 309 Palmer Court, Slidell, LA 70458, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Nguyen
authors.affiliation: Research Institute for Marine Drugs and Nutrition, College for Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong 524025, China.
authors.forename: Cai
authors.initials: C
authors.lastname: Song
authors.affiliation: Department of Psychology, University of Minnesota, Elliot Hall, Minneapolis, MN 55455, USA.
authors.forename: Irving I
authors.initials: II
authors.lastname: Gottesman
mesh_terms: D001927:Brain Diseases / Q000188:drug therapy* / Q000235:genetics; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008956:Models, Chemical; D018696:Neuroprotective Agents / Q000627:therapeutic use*
chemical_list: D018696:Neuroprotective Agents
keywords: Drug sensitivity predictor; Drug target; Efficacy; Endophenotype; Psychopharmacotherapy