title: PHACES syndrome: Diode laser photocoagulation of intraoral hemangiomas in six young patients.
abstract: BACKGROUND
  The acronym PHACES describes the association of posterior fossa malformations, facial hemangiomas, arterial anomalies (cardiovascular or cerebrovascular), coarctation of the aorta and cardiac defects, eye abnormalities, and sternal or ventral defects. In this study we report on 6 patients affected by the PHACES syndrome and showing 34 intraoral hemangiomas (IH), treated by diode laser photocoagulation (DLP).
  
  
  METHODS
  IH appeared as red-bluish soft masses, smooth or lobulated, from a few millimetre to several centimetres in size, covered by intact mucosa and blanching on pressure. IHs were treated by DLP with 320μm fibres at a wavelength of 800±10nm. The diode laser techniques applied were: Transmucosal DLP (DLTP), a no-contact technique in which laser energy is delivered by a flexible optic quartz fiber, which is kept 2-3mm apart from the lesion, and Intralesional DLP (DLIP), in which the fibre is introduced into the lesion through a transmucosal access. DLTP was used for 20 flat, superficial IHs and, after a variable number of laser sessions (average=3) depending on the size of the lesion, 65% completely regressed, while in the remaining 35% shrinkage of the lesion was achieved with minor and few complications. The remaining 14 deep/multi-lobulated IHs were treated by DLIP, resulting in complete regression of 79% of them.
  
  
  CONCLUSIONS
  DLP techniques are an effective and minimally invasive procedure for IH in patients with PHACES, in consideration of the multiple lesions to treat, of the necessity of multiple interventions and the higher compliance of the patients.
authors.affiliation: Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology, Aldo Moro University, 70124 Bari, Italy. Electronic address: gianfranco.favia@uniba.it.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Favia
authors.affiliation: Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology, Aldo Moro University, 70124 Bari, Italy. Electronic address: lululimongelli@gmail.com.
authors.forename: Luisa
authors.initials: L
authors.lastname: Limongelli
authors.affiliation: Department of Interdisciplinary Medicine, Complex Operating Unit of Odontostomatology, Aldo Moro University, 70124 Bari, Italy. Electronic address: angelatempesta1989@gmail.com.
authors.forename: Angela
authors.initials: A
authors.lastname: Tempesta
authors.affiliation: Medical School, Aldo Moro University, 70124 Bari, Italy. Electronic address: campomarinese@libero.it.
authors.forename: Matteo
authors.initials: M
authors.lastname: Favia
authors.affiliation: Department of Emergency and Organ Transplantation, Pathological Anatomy, Aldo Moro University, 70124 Bari, Italy. Electronic address: eugenio.maiorano@uniba.it.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Maiorano
keywords: Laser treatment; Rare disease; Vascular tumor