title: Chronological changes in stenosis of translocated coronary arteries on angiography after the arterial switch operation in children with transposition of the great arteries: comparison of myocardial scintigraphy and angiographic findings.
abstract: BACKGROUND
  The peri-operative mortality of the arterial switch operation in neonates with transposition of the great arteries is considerably low; however, long-term outcomes of translocated coronary arteries still remain one of the most crucial issues. Methods and results A total of 110 neonates with transposition of the great arteries after arterial switch operation were evaluated; three (2.7%) late deaths occurred. The remaining 107 patients except for one underwent follow-up angiography. Angiography showed coronary artery stenosis in nine (8.4%), with right coronary artery lesions in two and left main trunk lesions in seven. In two patients, right coronary artery stenosis regressed during follow-up. In left main trunk lesions, the severity of stenosis improved in four, did not change in one, and progressed to total occlusion in two patients. In children with coronary artery stenosis, myocardial scintigraphy showed perfusion defects in five out of six (83%) with left main trunk with ⩾75% stenosis and in four out of four with left main trunk stenosis ⩾90%. In contrast, patients whose coronary artery stenosis disappeared during follow-up had no perfusion defects on scintigraphy.
  
  
  CONCLUSIONS
  Regression of ostial stenosis of the transplanted coronary artery on angiogram was observed. The stenosis regressed over time in six patients; two coronary arteries with 99% stenosis and delayed angiographic enhancement of the distal coronary artery resulted in total occlusion within 1 year after the arterial switch operation. Combination of angiography and myocardial scintigraphy could be useful to differentiate deceptive stenosis from progressive stenosis.
authors.affiliation: Department of Pediatric Cardiology,National Cerebral and Cardiovascular Center,Osaka,Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sugiyama
authors.affiliation: Department of Pediatric Cardiology,National Cerebral and Cardiovascular Center,Osaka,Japan.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tsuda
authors.affiliation: Department of Pediatric Cardiology,National Cerebral and Cardiovascular Center,Osaka,Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Ohuchi
authors.affiliation: Department of Pediatric Cardiology,National Cerebral and Cardiovascular Center,Osaka,Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamada
authors.affiliation: Department of Pediatric Cardiology,National Cerebral and Cardiovascular Center,Osaka,Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Shiraishi
mesh_terms: D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D055414:Myocardial Perfusion Imaging; D012189:Retrospective Studies; D013997:Time Factors; D014188:Transposition of Great Vessels / Q000601:surgery*
keywords: Transposition of the great arteries; arterial switch operation; coronary artery stenosis; myocardial scintigraphy