title: A novel nucleoside from the edible mushroom, Tricholoma japonicum.
abstract: A novel nucleoside, 9-β-D-ribopyranosylpurine (2), along with three known nucleosides, adenosine (1), uridine (3) and nebularine (4), were isolated from the edible mushroom, Tricholoma japonicum. The structure of 2 was determined as 9-β-D-ribopyranosylpurine by comparing the reported spectral data of 2 with that of a synthetic compound. Isolation of the glycoside, which contains the sugar ribopyranose, from natural resources is very unusual. There are reports on the synthesis of 9-β-D-ribopyranosylpurine (2), but this is the first report on the isolation from natural resources. The antiproliferative activity of compounds 1-4 was evaluated using human umbilical vein endothelial cells. Compound 4 showed the highest inhibitory activity.
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Noshio 2-522-1, Kiyose, Tokyo, 204-8588, Japan.
authors.forename: Akane
authors.initials: A
authors.lastname: Haraguchi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Miyuki
authors.initials: M
authors.lastname: Fukai
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Koyama
mesh_terms: D009699:N-Glycosyl Hydrolases / Q000378:metabolism*; D055439:Tricholoma / Q000235:genetics*
chemical_list: D009699:N-Glycosyl Hydrolases