title: The association of ICAM E469K with cardiovascular characteristics of acromegaly.
abstract: OBJECTIVE
  It has been shown that genetic factors have a role in the development of acromegaly. We aimed to investigate the association between intercellular adhesion molecule (ICAM)-1 E469K polymorphism and some cardiovascular clinical parameters of acromegalic patients.
  
  
  METHODS
  We included 41 patients with acromegaly and 65 healthy subjects with similar age and sex to the study. Fasting plasma glucose (FPG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG) were analyzed. Genotyping was made by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  The frequency of genotype and allel ICAM-1 E469K was not significantly different between control and patients (p > 0.05). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and FPG levels were significantly higher, and HDL-C was significantly lower in patients with KK genotypes compared to patients with EE genotype in acromegaly group (p < 0.05).
  
  
  CONCLUSIONS
  This is the first study to investigate the role of ICAM gene polymorphism in acromegaly and its cardiovascular characteristics. ICAM E469K may not be a risk factor for the acromegaly in Turkish population but may be associated with hypertension, higher FPG and lower HDL-C in acromegalic patients.
authors.affiliation: Department of Medical Pharmacology, Faculty of Medicine, Harran University, Sanliurfa, Turkey. eoguz73@yahoo.com.
authors.forename: E
authors.initials: E
authors.lastname: Oguz
authors.forename: S
authors.initials: S
authors.lastname: Tabur
authors.forename: H
authors.initials: H
authors.lastname: Akbas
authors.forename: I V
authors.initials: IV
authors.lastname: Duzen
authors.forename: H
authors.initials: H
authors.lastname: Karabag
authors.forename: F
authors.initials: F
authors.lastname: Akkafa
authors.forename: M
authors.initials: M
authors.lastname: Ozkaya
authors.forename: B
authors.initials: B
authors.lastname: Alasehirli
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000235:genetics*; D000328:Adult; D001794:Blood Pressure; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; C573420:ICAM1 protein, human; D014280:Triglycerides; D018799:Intercellular Adhesion Molecule-1