title: Biodegradable soy wound dressings with controlled release of antibiotics: Results from a guinea pig burn model.
abstract: There is growing interest in the development of biodegradable materials from renewable biopolymers, such as soy protein, for biomedical applications. Soy protein is a major fraction of natural soybean and has the advantages of being economically competitive, biodegradable and biocompatible. It presents good water resistance as well as storage stability. In the current study, homogenous antibiotic-loaded soy protein films were cast from aqueous solutions. The antibiotic drug gentamicin was incorporated into the films in order to inhibit bacterial growth, and thus prevent or combat infection, upon its controlled release to the surrounding tissue. The current in vivo study of the dressing material in contaminated deep second-degree burn wounds in guinea pigs (n=20) demonstrated its ability to accelerate epithelialization with 71% epithelial coverage compared to an unloaded format of the soy material (62%) and a significant improved epithelial coverage as compared to the conventional dressing material (55%). Our new platform of antibiotic-eluting wound dressings is advantageous over currently used popular dressing materials that provide controlled release of silver ions, due to its gentamicin release profile, which is safer. Another advantage of our novel concept is that it is based on a biodegradable natural polymer and therefore does not require bandage changes and offers a potentially valuable and economic approach for treating burn-related infections.
authors.affiliation: Department of Plastic Surgery, Kaplan Medical Center, Rehovot, Israel; Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 32000, Israel.
authors.forename: Dana
authors.initials: D
authors.lastname: Egozi
authors.affiliation: Department of Biomedical Engineering, Tel-Aviv University, Tel-Aviv 69978, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Baranes-Zeevi
authors.affiliation: Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 32000, Israel; Department of Plastic Surgery and the Burn Unit, Rambam Health Care Campus, Haifa, Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Ullmann
authors.affiliation: Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 32000, Israel.
authors.forename: Amos
authors.initials: A
authors.lastname: Gilhar
authors.affiliation: Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 32000, Israel; Department of Plastic Surgery and the Burn Unit, Rambam Health Care Campus, Haifa, Israel.
authors.forename: Aviad
authors.initials: A
authors.lastname: Keren
authors.affiliation: Department of Plastic Surgery and the Burn Unit, Rambam Health Care Campus, Haifa, Israel.
authors.forename: Elias
authors.initials: E
authors.lastname: Matanes
authors.affiliation: Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 32000, Israel.
authors.forename: Israela
authors.initials: I
authors.lastname: Berdicevsky
authors.affiliation: Faculty of Medicine, Technion - Israel Institute of Technology, Haifa 32000, Israel.
authors.forename: Norberto
authors.initials: N
authors.lastname: Krivoy
authors.affiliation: Department of Biomedical Engineering, Tel-Aviv University, Tel-Aviv 69978, Israel. Electronic address: meitalz@eng.tau.ac.il.
authors.forename: Meital
authors.initials: M
authors.lastname: Zilberman
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001458:Bandages; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002056:Burns / Q000628:therapy*; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D005839:Gentamicins / Q000008:administration & dosage* / Q000494:pharmacology; D006168:Guinea Pigs; D030262:Soybean Proteins / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D005839:Gentamicins; D030262:Soybean Proteins
keywords: Gentamicin; Histology; Infection; Soy protein; Wound healing