title: Primary mucosal malignant melanoma of the cervix: case report and review of the literature.
abstract: The incidence of primary mucosal malignant melanoma (PMMM) is 1.3% among all malignant melanomas (MM). Cervical involvement is very rare; the number of cases of cervical PMMM reported so far is around 80. In our patient, a dark color, 2-cm diameter, nonulcerated tumor formation was observed upon examination of the cervix. Tumoral tissue consisted of atypical melanocytic cells containing numerous mitotic figures. In immunochemical studies, S-100, Melan-A, and HMB-45 positivity were observed. The tumor was 20 mm in invasion depth, Breslow IV, and FIGO stage IB1. Radical surgery was followed by adjuvant radiotherapy, and subsequently interferon treatment was applied. Examination and scans 20 months after surgery were free from tumor.
authors.affiliation: Ankara Oncology Education and Research Hospital, Ankara - Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Cetinkaya
authors.forename: Emine
authors.initials: E
authors.lastname: Benzer
authors.forename: Haluk
authors.initials: H
authors.lastname: Dervisoglu
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D014408:Biomarkers, Tumor / Q000032:analysis*; D017024:Chemotherapy, Adjuvant; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry; D007372:Interferons / Q000008:administration & dosage; D058965:MART-1 Antigen / Q000032:analysis; D008545:Melanoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery* / Q000628:therapy; D058950:Melanoma-Specific Antigens / Q000032:analysis; D009092:Mucous Membrane / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D009418:S100 Proteins / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery* / Q000628:therapy; D058951:gp100 Melanoma Antigen
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D058950:Melanoma-Specific Antigens; C548637:PMEL protein, human; D009418:S100 Proteins; D058951:gp100 Melanoma Antigen; D007372:Interferons