title: The pediatric template of brain perfusion.
abstract: Magnetic resonance imaging (MRI) captures the dynamics of brain development with multiple modalities that quantify both structure and function. These measurements may yield valuable insights into the neural patterns that mark healthy maturation or that identify early risk for psychiatric disorder. The Pediatric Template of Brain Perfusion (PTBP) is a free and public neuroimaging resource that will help accelerate the understanding of childhood brain development as seen through the lens of multiple modality neuroimaging and in relation to cognitive and environmental factors. The PTBP uses cross-sectional and longitudinal MRI to quantify cortex, white matter, resting state functional connectivity and brain perfusion, as measured by Arterial Spin Labeling (ASL), in 120 children 7-18 years of age. We describe the PTBP and show, as a demonstration of validity, that global summary measurements capture the trajectories that demarcate critical turning points in brain maturation. This novel resource will allow a more detailed understanding of the network-level, structural and functional landmarks that are obtained during normal adolescent brain development.
authors.affiliation: Department of Radiology, University of Pennsylvania , Philadelphia, Pennsylvania 19104, USA.
authors.forename: Brian B
authors.initials: BB
authors.lastname: Avants
authors.affiliation: Department of Radiology, University of Pennsylvania , Philadelphia, Pennsylvania 19104, USA.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Duda
authors.affiliation: Department of Neurology, University of California , Los Angeles, California 90095, USA.
authors.forename: Emily
authors.initials: E
authors.lastname: Kilroy
authors.affiliation: Department of Neurology, University of California , Los Angeles, California 90095, USA.
authors.forename: Kate
authors.initials: K
authors.lastname: Krasileva
authors.affiliation: Department of Neurology, University of California , Los Angeles, California 90095, USA.
authors.forename: Kay
authors.initials: K
authors.lastname: Jann
authors.affiliation: Department of Radiology, University of Pennsylvania , Philadelphia, Pennsylvania 19104, USA.
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Kandel
authors.affiliation: Department of Radiology, University of Virginia , Charlottesville, Virginia 22904, USA.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Tustison
authors.affiliation: Department of Neurology, University of California , Los Angeles, California 90095, USA.
authors.forename: Lirong
authors.initials: L
authors.lastname: Yan
authors.affiliation: Department of Neurology, University of California , Los Angeles, California 90095, USA.
authors.forename: Mayank
authors.initials: M
authors.lastname: Jog
authors.affiliation: Department of Neurology, University of California , Los Angeles, California 90095, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Smith
authors.affiliation: Department of Neurology, University of California , Los Angeles, California 90095, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, University of California , Los Angeles, California 90095, USA.
authors.forename: Mirella
authors.initials: M
authors.lastname: Dapretto
authors.affiliation: Department of Neurology, University of California , Los Angeles, California 90095, USA.
authors.forename: Danny J J
authors.initials: DJ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D041923:Adolescent Development; D019412:Anatomy, Cross-Sectional; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply / Q000254:growth & development; D002648:Child; D002657:Child Development; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging