title: Are children on jejunal feeds at risk of iron deficiency?
abstract: Children on exclusive jejunal feeding may be at risk of iron deficiency due to the feeds bypassing the duodenum, which is the primary site for iron absorption. We describe the biochemical and hematological features of six children on exclusive jejunal feeding who did not receive iron supplementation. At a mean (standard deviation) period of 11 (6.5) mo after commencing jejunal feeds, there was a significant reduction in both serum iron (18.5 g/L vs 9.8 g/L, P = 0.01) and transferrin saturation levels (23.1% vs 13.7%, P = 0.02), suggesting iron deficiency. However, there was no significant change in ferritin, hemoglobin and mean corpuscular volume levels post-commencement of jejunal feeds. This may be the result of small bowel adaptation in response to early iron deficiency. Larger and longer term prospective studies are required to investigate if children on jejunal feeds are at risk of developing iron deficiency.
authors.affiliation: Li-Zsa Tan, Chee Y Ooi, Department of Gastroenterology, Sydney Children's Hospital, Randwick NSW 2031, Australia.
authors.forename: Li-Zsa
authors.initials: LZ
authors.lastname: Tan
authors.affiliation: Li-Zsa Tan, Chee Y Ooi, Department of Gastroenterology, Sydney Children's Hospital, Randwick NSW 2031, Australia.
authors.forename: Susan E
authors.initials: SE
authors.lastname: Adams
authors.affiliation: Li-Zsa Tan, Chee Y Ooi, Department of Gastroenterology, Sydney Children's Hospital, Randwick NSW 2031, Australia.
authors.forename: Alison
authors.initials: A
authors.lastname: Kennedy
authors.affiliation: Li-Zsa Tan, Chee Y Ooi, Department of Gastroenterology, Sydney Children's Hospital, Randwick NSW 2031, Australia.
authors.forename: Helen
authors.initials: H
authors.lastname: Kepreotes
authors.affiliation: Li-Zsa Tan, Chee Y Ooi, Department of Gastroenterology, Sydney Children's Hospital, Randwick NSW 2031, Australia.
authors.forename: Chee Y
authors.initials: CY
authors.lastname: Ooi
mesh_terms: D005260:Female; D015390:Gastric Bypass; D006801:Humans; D007583:Jejunum / Q000473:pathology*; D008297:Male; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors
keywords: Exclusive jejunal feeds; Iron deficiency; Jejunally fed children