title: Does ovarian stimulation for IVF increase gynaecological cancer risk? A systematic review and meta-analysis.
abstract: The aim of this study was to evaluate whether ovarian stimulation for IVF increases the risk of gynaecological cancer, including ovarian, endometrial, cervical and breast cancers, as an independent risk factor. A systematic review and meta-analysis was conducted. Clinical trials that examined the association between ovarian stimulation for IVF and gynaecologic cancers were included. The outcomes of interest were incidence rate of gynaecologic cancers. Twelve cohort studies with 178,396 women exposed to IVF were included; 10 studies were used to analyse ovarian (167,640 women) and breast (151,702 women) cancers, and six studies were identified in the analysis of endometrial (116,672 women) and cervical cancer (114,799 women). Among these studies, 175 ovarian, 48 endometrial, 502 cervical and 866 cases of breast cancer were reported. The meta-analysis found no significant association between ovarian stimulation for IVF and increased ovarian, endometrial, cervical and breast cancer risk (odds ratio [OR] 1.06, 95% confidence interval [CI] 0.85 to 1.32; OR 0.97, 95% CI 0.58 to 1.63; OR 0.43, 95% CI 0.30 to 0.60; OR 0.69, 95% CI 0.63 to 0.76, respectively). Ovarian stimulation for IVF, therefore, does not increase the gynaecologic cancer risk, whether hormone-dependent endometrial and breast cancer or non-hormone-dependent ovarian and cervical cancer.
authors.affiliation: Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: zhaojing19840427@sina.com.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Li
authors.affiliation: Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Reproductive Medicine Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005833:Genital Neoplasms, Female / Q000209:etiology*; D006801:Humans; D016017:Odds Ratio; D010062:Ovulation Induction / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors
keywords: breast cancer; cervical cancer; endometrial cancer; ovarian cancer; ovarian stimulation