title: Plasma peptidases as prognostic biomarkers in patients with first-episode psychosis.
abstract: The plasma activity of nine aminopeptidases was monitored over a year in first-episode psychotic patients. We observed significant differences in aminopeptidase B (APB), aminopeptidase N (APN) and dipeptidyl peptidase IV (DPPIV), but not in puromycin-sensitive aminopeptidase (PSA), prolyl endopeptidase (PEP), cysteine aminopeptidase (Cys-AP), aspartate aminopeptidase (Asp-AP), glutamate aminopeptidase (Glu) or piroglutamate aminopeptidase (PGI) in these patients compared to controls, and also a progressive increase in plasma activity, correlated to changes in scores on clinical scales, Global Assessment of Functioning scale (GAF) and Hamilton Depression Rating Scale (HDRS), at 1 month of follow-up. At 1 month after diagnosis, the median score obtained by patients on the GAF was negatively associated with the plasma activity of APB and PEP measured at the beginning of the psychotic episode, indicating a role as a negative prognostic factor that can predict psychiatric symptomatology. In the case of HDRS, scores at 1 month after diagnosis were found to be positively associated with the initial plasma activity of DPPIV, APN and PSA, indicating that their initial elevation is a negative prognostic factor that can predict subsequent depressive symptomatology. Taken together, these results suggest a pathophysiological involvement of plasma peptidases and indicate that aminopeptidase activity can predict the course of first-episode psychosis patients, acting as a prognostic indicator.
authors.affiliation: Department of Physiology, University of the Basque Country, Spain. Electronic address: ainhoafn@gmail.com.
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Fernández-Atucha
authors.affiliation: Department of Physiology, University of the Basque Country, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. Electronic address: enrique.etxebarria@ehu.es.
authors.forename: Enrique
authors.initials: E
authors.lastname: Echevarría
authors.affiliation: Department of Physiology, University of the Basque Country, Spain. Electronic address: gorka.larrinaga@ehu.es.
authors.forename: Gorka
authors.initials: G
authors.lastname: Larrinaga
authors.affiliation: Department of Physiology, University of the Basque Country, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. Electronic address: javier.gilgoikouria@ehu.es.
authors.forename: Javier
authors.initials: J
authors.lastname: Gil
authors.affiliation: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Hospital Universitario de Alava, Vitoria, Spain. Electronic address: MONICA.MARTINEZCENGOTITABENGOA@osakidetza.net.
authors.forename: Mónica
authors.initials: M
authors.lastname: Martínez-Cengotitabengoa
authors.affiliation: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain; Hospital Universitario de Alava, Vitoria, Spain. Electronic address: anamaria.gonzalez-pintoarrillaga@osakidetza.net.
authors.forename: Ana M
authors.initials: AM
authors.lastname: González-Pinto
authors.affiliation: Department of Physiology, University of the Basque Country, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain. Electronic address: jon.irazusta@ehu.es.
authors.forename: Jon
authors.initials: J
authors.lastname: Irazusta
authors.affiliation: Institute of Biomedicine (IBIOMED), University of León. Spain. Visiting Researcher and Professor University of the Basque Country, Spain. Electronic address: jesus.seco@unileon.es.
authors.forename: Jesús
authors.initials: J
authors.lastname: Seco
mesh_terms: D000328:Adult; D000626:Aminopeptidases / Q000097:blood* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D018826:CD13 Antigens / Q000097:blood* / Q000378:metabolism; D018819:Dipeptidyl Peptidase 4 / Q000097:blood* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000097:blood* / Q000378:metabolism; D011379:Prognosis; D000085822:Prolyl Oligopeptidases; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D012697:Serine Endopeptidases
chemical_list: D015415:Biomarkers; D010447:Peptide Hydrolases; D000626:Aminopeptidases; C075408:cysteine aminopeptidase; C025579:enkephalin degrading enzyme; D018826:CD13 Antigens; C019721:aminopeptidase B; D018819:Dipeptidyl Peptidase 4; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases
keywords: Clinical scales; First-episode psychosis; GAF; HDRS; Plasma aminopeptidase