title: Parametric response mapping of dynamic CT for predicting intrahepatic recurrence of hepatocellular carcinoma after conventional transcatheter arterial chemoembolization.
abstract: OBJECTIVE
  The aim of our study was to determine the diagnostic value of a novel image analysis method called parametric response mapping (PRM) for prediction of intrahepatic recurrence of hepatocellular carcinoma (HCC) treated with conventional transcatheter arterial chemoembolization (TACE).
  
  
  METHODS
  This retrospective study was approved by the IRB. We recruited 55 HCC patients who achieved complete remission (CR) after TACE and received longitudinal multiphasic liver computed tomography (CT). The patients fell into two groups: the recurrent tumour group (n = 29) and the non-recurrent tumour group (n = 26). We applied the PRM analysis to see if this technique could distinguish between the two groups. The results of the PRM analysis were incorporated into a prediction algorithm. We retrospectively removed data from the last time point and attempted to predict the response to therapy of the removed data.
  
  
  RESULTS
  The PRM analysis was able to distinguish between the non-recurrent and recurrent groups successfully. The prediction algorithm detected response to therapy with an area under the curve (AUC) of 0.76, while the manual approach had AUC 0.64.
  
  
  CONCLUSIONS
  Adopting PRM analysis can potentially distinguish between recurrent and non-recurrent HCCs and allow for prediction of response to therapy after TACE.
  
  
  CONCLUSIONS
  Parametric response mapping (PRM) could help assess patients with recurrent HCCs after TACE. Parametric response mapping could direct patients to individualized therapy. Longitudinal CT images were analyzed with advanced image analysis method.
authors.affiliation: Department of Radiology, Gachon University Gil Hospital, Incheon, Korea.
authors.forename: Seung Joon
authors.initials: SJ
authors.lastname: Choi
authors.affiliation: Department of Electronic Electrical and Computer Engineering, Sungkyunkwan University, Suwon, 440-746, Korea.
authors.forename: Jonghoon
authors.initials: J
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Yonsei University, Wonju, Korea.
authors.forename: Jongbum
authors.initials: J
authors.lastname: Seo
authors.affiliation: Department of Radiology, Gachon University Gil Hospital, Incheon, Korea.
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
authors.forename: Jong-min
authors.initials: JM
authors.lastname: Lee
authors.affiliation: School of Electronic and Electrical Engineering, Sungkyunwkan University, Suwon, 440-746, Korea. hyunjinp@skku.edu.
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000628:therapy; D002406:Catheterization, Peripheral / Q000379:methods*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000517:prevention & control; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents
keywords: Algorithms; Hepatocellular carcinoma; Longitudinal studies; Therapeutic chemoembolization; Tomography; X-Ray computed