title: Endothelium-derived ET-1 and the development of renal injury.
abstract: The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner.
authors.affiliation: Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Carmen
authors.initials: C
authors.lastname: De Miguel
authors.affiliation: Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama pollockj@uab.edu.
authors.forename: David M
authors.initials: DM
authors.lastname: Pollock
authors.affiliation: Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Pollock
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D019332:Endothelin-1 / Q000235:genetics / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D007684:Kidney Tubules / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D008955:Models, Cardiovascular; D019899:Paracrine Communication
chemical_list: D019332:Endothelin-1
keywords: apoptosis; endothelin-1; renal injury