title: A case of pediatric Steven-Johnson Syndrome associated with albuterol consumption.
abstract: We describe a case of Steven-Johnson Syndrome (SJS) associated with albuterol exposure in a 6-year-old male. A possible contributing role of albuterol in SJS occurrence in the present case is strongly suggested by the temporal relationship between the event and the initiation of drug therapy as well as by the positive rechallenge. To the best of our knowledge, albuterol had not been previously associated with SJS in medical literature. It can be therefore possible that physicians, pediatricians in particular, probably not aware of the possible risk of albuterol-induced SJS, might underestimate skin reactions in children taking the drug, thus underreporting this kind of severe adverse drug reaction.
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Tuscan Regional Centre of Pharmacovigilance, University of Florence, 50139 Florence, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Maggini
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Tuscan Regional Centre of Pharmacovigilance, University of Florence, 50139 Florence, Italy.
authors.forename: Niccolò
authors.initials: N
authors.lastname: Lombardi
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Tuscan Regional Centre of Pharmacovigilance, University of Florence, 50139 Florence, Italy.
authors.forename: Maria Carmela
authors.initials: MC
authors.lastname: Lenti
authors.affiliation: Department of Emergency Medicine, Anna Meyer Children's University Hospital, 50141 Florence, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Masi
authors.affiliation: Department of Pediatrics, Anna Meyer Children's University Hospital, 50141 Florence, Italy.
authors.forename: Sandra
authors.initials: S
authors.lastname: Trapani
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Tuscan Regional Centre of Pharmacovigilance, University of Florence, 50139 Florence, Italy. Electronic address: alessandra.pugi@gmail.com.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pugi
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Tuscan Regional Centre of Pharmacovigilance, University of Florence, 50139 Florence, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mugelli
authors.affiliation: Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Tuscan Regional Centre of Pharmacovigilance, University of Florence, 50139 Florence, Italy.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Vannacci
mesh_terms: D000420:Albuterol / Q000009:adverse effects* / Q000627:therapeutic use; D001249:Asthma / Q000150:complications / Q000188:drug therapy* / Q000628:therapy; D001993:Bronchodilator Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D008297:Male; D060735:Pharmacovigilance; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy
chemical_list: D001993:Bronchodilator Agents; D016756:Immunoglobulins, Intravenous; D000420:Albuterol
keywords: Albuterol; Asthma; Emergency department; Pediatrics; Pharmacovigilance; Steven–Johnson Syndrome