title: Are ERAD components involved in cross-presentation?
abstract: A long unanswered question in the antigen presentation field is how exogenous antigens cross-presented by Major Histocompatibility Complex class I (MHC-I) molecules to CD8(+) T cells are translocated into the cytosol. Here we discuss the known mechanisms involved in this process with a focus on the hypothesized role of the machinery that functions in endoplasmic reticulum-associated degradation (ERAD). Other potential mechanisms of antigen entry to the cytosol are also discussed.
authors.affiliation: Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Jeff E
authors.initials: JE
authors.lastname: Grotzke
authors.affiliation: Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: peter.cresswell@yale.edu.
authors.forename: Peter
authors.initials: P
authors.lastname: Cresswell
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000235:genetics / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D045142:Cross-Priming; D003600:Cytosol / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D060746:Endoplasmic Reticulum-Associated Degradation / Q000235:genetics / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics / Q000276:immunology; D021381:Protein Transport; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000276:immunology
chemical_list: D000941:Antigens; D015395:Histocompatibility Antigens Class I; D009687:Nuclear Proteins; C094680:nuclear protein import factor p97; D044767:Ubiquitin-Protein Ligases
keywords: Antigen processing; Cross-presentation; Dendritic cells; ERAD; MHC