title: Renin and aldosterone measurements in the management of arterial hypertension.
abstract: Renin-angiotensin-aldosterone system (RAAS) is recognized as the main regulatory system of hemodynamics in man, and its derangements have a key role in the development and maintenance of arterial hypertension. Classification of the hypertensive states according to different patterns of renin and aldosterone levels ("RAAS profiling") allows the diagnosis of specific forms of secondary hypertension and may identify distinct hemodynamic subsets in essential hypertension. In this review, we summarize the application of RAAS profiling for the diagnostic assessment of hypertensive patients and discuss how the pathophysiological framework provided by RAAS profiling may guide therapeutic decision-making, especially in the context of uncontrolled hypertension not responding to multi-therapy.
authors.affiliation: Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Viola
authors.affiliation: Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Monticone
authors.affiliation: Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: J
authors.initials: J
authors.lastname: Burrello
authors.affiliation: Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Buffolo
authors.affiliation: Clinical Chemistry Laboratory, University of Torino, Torino, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Lucchiari
authors.affiliation: Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Rabbia
authors.affiliation: Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: T A
authors.initials: TA
authors.lastname: Williams
authors.affiliation: Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Veglio
authors.affiliation: Clinical Chemistry Laboratory, University of Torino, Torino, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Mengozzi
authors.affiliation: Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Torino, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Mulatero
mesh_terms: D000450:Aldosterone / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis*; D012083:Renin / Q000097:blood*
chemical_list: D000450:Aldosterone; D012083:Renin