title: Yolk-Shell Porous Microspheres of Calcium Phosphate Prepared by Using Calcium L-Lactate and Adenosine 5'-Triphosphate Disodium Salt: Application in Protein/Drug Delivery.
abstract: A facile and environmentally friendly approach has been developed to prepare yolk-shell porous microspheres of calcium phosphate by using calcium L-lactate pentahydrate (CL) as the calcium source and adenosine 5'-triphosphate disodium salt (ATP) as the phosphate source through the microwave-assisted hydrothermal method. The effects of the concentration of CL, the microwave hydrothermal temperature, and the time on the morphology and crystal phase of the product are investigated. The possible formation mechanism of yolk-shell porous microspheres of calcium phosphate is proposed. Hemoglobin from bovine red cells (Hb) and ibuprofen (IBU) are used to explore the application potential of yolk-shell porous microspheres of calcium phosphate in protein/drug loading and delivery. The experimental results indicate that the as-prepared yolk-shell porous microspheres of calcium phosphate have relatively high protein/drug loading capacity, sustained protein/drug release, favorable pH-responsive release behavior, and a high biocompatibility in the cytotoxicity test. Therefore, the yolk-shell porous microspheres of calcium phosphate have promising applications in various biomedical fields such as protein/drug delivery.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (P.R. China), Fax: (+86) 21-52413122.
authors.forename: Guan-Jun
authors.initials: GJ
authors.lastname: Ding
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (P.R. China), Fax: (+86) 21-52413122. y.j.zhu@mail.sic.ac.cn.
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (P.R. China), Fax: (+86) 21-52413122.
authors.forename: Chao
authors.initials: C
authors.lastname: Qi
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (P.R. China), Fax: (+86) 21-52413122.
authors.forename: Tuan-Wei
authors.initials: TW
authors.lastname: Sun
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (P.R. China), Fax: (+86) 21-52413122.
authors.forename: Jin
authors.initials: J
authors.lastname: Wu
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050 (P.R. China), Fax: (+86) 21-52413122.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry*; D000818:Animals; D017610:Calcium Compounds / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002417:Cattle; D016503:Drug Delivery Systems; D006454:Hemoglobins / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry; D007773:Lactates / Q000737:chemistry*; D008422:Materials Testing; D008863:Microspheres; D016062:Porosity; D011506:Proteins / Q000737:chemistry*
chemical_list: D017610:Calcium Compounds; D002130:Calcium Phosphates; D006454:Hemoglobins; D007773:Lactates; D011506:Proteins; C110051:calcium lactate; D000255:Adenosine Triphosphate; C020243:calcium phosphate; D007052:Ibuprofen
keywords: Calcium phosphate; drug delivery; microwave chemistry; nanostructures; porous materials