title: Relationship between activity of gluthatione peroxidase and nitric oxide in synovial fluid and the progression of temporomandibular joint internal derangement.
abstract: The purposes of this study were to measure the activity of glutathione peroxidase (GPX) and nitric oxide (NO) in the synovial fluid of patients with temporomandibular joint (TMJ) internal derangement (ID) and to indicate the relationship between the activity of GPX and NO and the progress of the ID. Twenty-six patients with TMJ ID were identified and classified according to Wilkes staging through clinical and radiologic examinations. Levels of GPX were determined indirectly by a coupled reaction with glutathione reductase. Levels of NO were measured colorimetrically. The activity of GPX and NO was observed to be progressively increasing as the stage of the TMJ ID progressed. There were significant correlations between the 2 substances and the Wilkes stages. Oxidative stress may have a role in the pathogenesis of TMJ ID. In synovial fluid, GPX and NO activities are increased as the stage of the disease increased. Increase in the activities of GPX might not be enough to prevent progression of the TMJ ID.
authors.affiliation: *Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Ankara, Ankara †Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Akdeniz University, Antalya ‡Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Kirikkale, Kirikkale §Department of Biochemistry, Faculty of Veterinary Medicine, University of Ankara, Ankara, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Güven
authors.forename: Sinan
authors.initials: S
authors.lastname: Tozoğlu
authors.forename: Umut
authors.initials: U
authors.lastname: Tekin
authors.forename: Berrin
authors.initials: B
authors.lastname: Salmanoğlu
authors.forename: Onur
authors.initials: O
authors.lastname: Güneş
mesh_terms: D000293:Adolescent; D000328:Adult; D018450:Disease Progression; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D004204:Joint Dislocations / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D013582:Synovial Fluid / Q000737:chemistry*; D013704:Temporomandibular Joint; D013705:Temporomandibular Joint Disorders / Q000378:metabolism*; D055815:Young Adult
chemical_list: D009569:Nitric Oxide; D005979:Glutathione Peroxidase