title: Insights into bombesin receptors and ligands: Highlighting recent advances.
abstract: This following article is written for Prof. Abba Kastin's Festschrift, to add to the tribute to his important role in the advancement of the role of peptides in physiological, as well as pathophysiological processes. There have been many advances during the 35 years of his prominent role in the Peptide field, not only as editor of the journal Peptides, but also as a scientific investigator and editor of two volumes of the Handbook of Biological Active Peptides [146,147]. Similar to the advances with many different peptides, during this 35 year period, there have been much progress made in the understanding of the pharmacology, cell biology and the role of (bombesin) Bn receptors and their ligands in various disease states, since the original isolation of bombesin from skin of the European frog Bombina bombina in 1970 [76]. This paper will briefly review some of these advances over the time period of Prof. Kastin 35 years in the peptide field concentrating on the advances since 2007 when many of the results from earlier studies were summarized [128,129]. It is appropriate to do this because there have been 280 articles published in Peptides during this time on bombesin-related peptides and it accounts for almost 5% of all publications. Furthermore, 22 Bn publications we have been involved in have been published in either Peptides [14,39,55,58,81,92,93,119,152,216,225,226,231,280,302,309,355,361,362] or in Prof. Kastin's Handbook of Biological Active Peptides [137,138,331].
authors.affiliation: Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States.
authors.forename: Irene
authors.initials: I
authors.lastname: Ramos-Álvarez
authors.affiliation: Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States.
authors.forename: Paola
authors.initials: P
authors.lastname: Moreno
authors.affiliation: Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States.
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Mantey
authors.affiliation: Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States.
authors.forename: Taichi
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States.
authors.forename: Bernardo
authors.initials: B
authors.lastname: Nuche-Berenguer
authors.affiliation: Center for Cancer Research, Office of the Director, NCI, National Institutes of Health, Bethesda, MD 20892-1804, United States.
authors.forename: Terry W
authors.initials: TW
authors.lastname: Moody
authors.affiliation: Peptide Research Laboratory, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112-2699, United States.
authors.forename: David H
authors.initials: DH
authors.lastname: Coy
authors.affiliation: Digestive Diseases Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892-1804, United States. Electronic address: robertj@bdg10.niddk.nih.gov.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Jensen
mesh_terms: D000818:Animals; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008024:Ligands; D010455:Peptides / Q000737:chemistry* / Q000266:history / Q000378:metabolism*; D010506:Periodicals as Topic / Q000266:history; D018004:Receptors, Bombesin / Q000819:agonists* / Q000266:history
chemical_list: D008024:Ligands; D010455:Peptides; D018004:Receptors, Bombesin
keywords: Bombesin; Gastrin releasing peptide; Neuromedin b; Obesity; Pruritus