title: Correlation of Interleukin-6 levels and lectins during Schistosoma haematobium infection.
abstract: Urogenital schistosomiasis caused by Schistosoma haematobium induces a Th2 immune response, including expression of Interleukin-6. IL-6 confers protection from experimental Schistosoma-induced pulmonary hypertension and modulates production of mannose-binding lectin (MBL) and other lectins. We studied IL-6 levels in schistosomiasis and its effect on lectins production. Elevated IL-6 levels occurred in cases, compared to controls. IL-6 correlated with the lectins MBL, ficolin-2 and Collectin Kidney-1 (CL-K1) in cases, but correlated inversely in controls. The study shows that IL-6 levels are elevated in individuals infected with urogenital schistosomiasis. IL-6 was also found to be correlated with the production of lectins in S. haematobium infection. A similar correlation between IL-6 and MBL was observed during visceral leishmaniasis.
authors.affiliation: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
authors.forename: Justin S
authors.initials: JS
authors.lastname: Antony
authors.affiliation: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
authors.forename: Olusola
authors.initials: O
authors.lastname: Ojurongbe
authors.affiliation: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors.forename: Christian G
authors.initials: CG
authors.lastname: Meyer
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: Kumarasamy
authors.initials: K
authors.lastname: Thangaraj
authors.affiliation: CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
authors.forename: Anshuman
authors.initials: A
authors.lastname: Mishra
authors.affiliation: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Kremsner
authors.affiliation: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany; Fondation Congolaise pour la Recherche Medicale, Brazzaville, People's Republic of Congo. Electronic address: velavan@medizin.uni-tuebingen.de.
authors.forename: Thirumalaisamy P
authors.initials: TP
authors.lastname: Velavan
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D037222:Collectins / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D037102:Lectins / Q000097:blood*; D007893:Leishmania donovani; D007898:Leishmaniasis, Visceral / Q000276:immunology; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood / Q000737:chemistry; D009549:Nigeria / Q000453:epidemiology; D010270:Parasite Egg Count; D012548:Schistosoma haematobium / Q000276:immunology; D012553:Schistosomiasis haematobia / Q000453:epidemiology / Q000276:immunology* / Q000469:parasitology
chemical_list: D000909:Antibodies, Helminth; D037222:Collectins; C508600:IL6 protein, human; D015850:Interleukin-6; D037102:Lectins; D037601:Mannose-Binding Lectin
keywords: CL-K1; Ficolin-2; IL-6; MBL; Schistosomiasis