title: Comparative clinical evaluation on herbal formulation Pepsil, Safoof-e-Katira and Omeprazole in gastro esophageal reflux disease.
abstract: This study was conducted to evaluate the role of Unani herbal drugs Pepsil and Safoof-e-katira on the gastro esophageal reflux disease (GERD). This was multicentre randomized case control study conducted at Matab Hakeem Muhammad Noor-ud-din, Burewala; Aziz Muhammad din Medical and Surgical Centre, Burewala and Shifa-ul-mulk Memorial Hospital, Hamdard University Karachi. The patients were selected according to inclusion and exclusion criteria. In test group-1 the male female ratio was 40%, 60%; test group-2 was 42%, 58% and in control group was 44%, 56% respectively. The observed symptoms in the study were increased appetite (TG-1-95%, TG-2-95% and CG-89%), difficulty in swallowing (TG-1-93%, TG-2-96% and TC-94%), belching/burping (TG-1-97%, TG-2-97% and CG-95%), vomiting (TG-1-90%, TG-2-96% and CG-89%), heart burn (TG-1-100%, TG-2-100% and CG-98%), palpitation (TG-1-100%, TG-2-100% and CG-97%), epigastric pain (TG-1-97%, TG-2-97% and CG-90%), abdominal cramps (TG-1-97%, TG-2-98% and CG-95%), tenesmus (TG-1-100%, TG-2-100% and CG-97%), flatulence (TG-1-100%, TG-2-75% and CG-95%), wakeup during sleep (TG-1-94%, TG-2-87% and CG-94%). The p-value of the results of the symptoms was 0.000 except flatulence where the value was 0.001. The statistical results of the study prescribed that all the drugs studied (Pepsil, Safoof-e-katira and Omeprazole) are highly significant. The herbal coded drug Pepsil showed no side effects and unani herbal drug safoof-e-katira showed minimum result of 75% in the patients while Omeprazole resulted with some side effects. In the result it can be concluded that the herbal coded drug Pepsil is a potent herbal drug for gastro esophageal reflux disease.
authors.affiliation: Faculty of Eastern Medicine, Hamdard University, Karachi, Pakistan.
authors.forename: Muhammad Umar
authors.initials: MU
authors.lastname: Toseef
authors.affiliation: Faculty of Eastern Medicine, Hamdard University, Karachi, Pakistan.
authors.forename: Aftab
authors.initials: A
authors.lastname: Saeed
authors.affiliation: Faculty of Eastern Medicine, Hamdard University, Karachi, Pakistan.
authors.forename: Ejaz
authors.initials: E
authors.lastname: Mohi-Ud-Din
authors.affiliation: Research and Development Department, Herbion Pakistan (Pvt.) Limited, Korangi Industrial Area, Karachi, Pakistan.
authors.forename: Khan
authors.initials: K
authors.lastname: Usmanghani
authors.affiliation: Faculty of Eastern Medicine, Hamdard University, Karachi, Pakistan.
authors.forename: Halima
authors.initials: H
authors.lastname: Nazar
authors.affiliation: Research and Development Department, Herbion Pakistan (Pvt.) Limited, Korangi Industrial Area, Karachi, Pakistan.
authors.forename: Allah
authors.initials: A
authors.lastname: Nawaz
authors.forename: Irshad
authors.initials: I
authors.lastname: Ahmad
authors.affiliation: Research and Development Department, Herbion Pakistan (Pvt.) Limited, Korangi Industrial Area, Karachi, Pakistan.
authors.forename: Faheem Ahmed
authors.initials: FA
authors.lastname: Siddiqui
mesh_terms: D027884:Astragalus gummifer; D028526:Coriandrum; D003680:Deglutition Disorders / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy*; D006356:Heartburn / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use*; D029803:Phyllanthus; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D010943:Plantago; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D014144:Tragacanth; D016896:Treatment Outcome
chemical_list: D028321:Plant Preparations; D054328:Proton Pump Inhibitors; D014144:Tragacanth; D009853:Omeprazole