title: Real-time treatment light dose guidance of Pleural PDT: an update.
abstract: The goal of this study was to develop and improve an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, several detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. Monte-Carlo simulation is used to improve the calculation algorithm for the effect of light that undergoes multiple scattering along the surface in addition to an improvement of the direct light calculation using an improved model that accounts for the anisotropy of the light from the light source.
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Zhu
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA ; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Kim
authors.affiliation: Biomedical engineering, Oregon Health & Science University, Portland, OR.
authors.forename: Steve L
authors.initials: SL
authors.lastname: Jacques
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Rozhin
authors.initials: R
authors.lastname: Penjweini
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Andreea
authors.initials: A
authors.lastname: Dimofte
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Jarod C
authors.initials: JC
authors.lastname: Finlay
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Simone
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Cengel
authors.affiliation: Division of Thoracic Surgery, Penn Presbyterian Medical Center, Wright-Saunders, Suite 266, 51 N 39 Street, PA 19104.
authors.forename: Joseph
authors.initials: J
authors.lastname: Friedberg
keywords: MC simulation; Photodynamic therapy; intra-cavitary treatment planning; light dosimetry; light fluence