title: Colistin and neurotoxicity: recommendations for optimal use in cystic fibrosis patients.
abstract: Case description The use of i.v. colistin reappeared recently for the treatment of multidrug-resistant Gram negative organisms in the intensive care and cystic fibrosis (CF) setting. According to the latest pharmacokinetic data, a loading dose and high antibiotic doses are given. Two cases of adverse events (paraesthesias, bad taste) were observed immediately after the start of infusion of a high dose of i.v. colistin in adult CF patients at the Ghent University Hospital. Conclusion Recommendations for optimal administration of i.v. colistin in adult CF patients are scarce. This article highlights the importance of mode of administration to avoid toxicity and relates it to recent pharmacokinetic/-dynamic literature.
authors.affiliation: Pharmacy Department, Ghent University Hospital, K12 Floor -1, De Pintelaan 185, 9000, Ghent, Belgium, barbara.claus@uzgent.be.
authors.forename: Barbara O M
authors.initials: BO
authors.lastname: Claus
authors.forename: Sylvia
authors.initials: S
authors.lastname: Snauwaert
authors.forename: Filomeen
authors.initials: F
authors.lastname: Haerynck
authors.forename: Sabine
authors.initials: S
authors.lastname: Van Daele
authors.forename: Frans
authors.initials: F
authors.lastname: De Baets
authors.forename: Petra
authors.initials: P
authors.lastname: Schelstraete
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003091:Colistin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000150:complications*; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010292:Paresthesia / Q000139:chemically induced
chemical_list: D000900:Anti-Bacterial Agents; D003091:Colistin