title: A Technical Review of Minimally Invasive Mitral Valve Replacements.
abstract: Mitral regurgitation is one of the most common forms of heart valve disorder, which may result in heart failure. Due to the rapid ageing of the population, surgical repair and replacement treatments, which have represented an effective treatment in the past, are now unsuitable for about half of symptomatic patients, who are judged high-risk. Encouraged by the positive experience with transcatheter aortic valves and percutaneous reconstructive mitral treatments, a number of research groups are currently engaged in the development of minimally invasive approaches for the functional replacement of the mitral valve. The first experiences have clearly demonstrated that the approach is feasible and promising, though significant progress is still required in the prostheses design and implantation procedures before the treatment can establish as a safe and effective solution. This review analyses the devices currently at a most advanced stage of development, describing their main features and the technical solutions that they adopt in order to respond to the functional requirements of the most challenging of the heart valves.
authors.affiliation: Cardiovascular Engineering Laboratory, UCL Mechanical Engineering, Torrington Place, London, WC1E 7JE UK.
authors.forename: Georgia L
authors.initials: GL
authors.lastname: Preston-Maher
authors.affiliation: Cardiovascular Engineering Laboratory, UCL Mechanical Engineering, Torrington Place, London, WC1E 7JE UK.
authors.forename: Ryo
authors.initials: R
authors.lastname: Torii
authors.affiliation: Cardiovascular Engineering Laboratory, UCL Mechanical Engineering, Torrington Place, London, WC1E 7JE UK.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Burriesci
mesh_terms: D006328:Cardiac Catheterization / Q000295:instrumentation; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D011474:Prosthesis Design / Q000295:instrumentation*; D016896:Treatment Outcome
keywords: Mitral valve; TAVI; TMVI; Transcatheter heart valve replacement