title: Neurolymphomatosis: MRI and (18) FDG-PET features.
abstract: Neurolymphomatosis (NL) is a rare presentation of lymphoma or leukemic infiltration of cranial or peripheral nerves. It is distinct from subarachnoid seeding of lymphoma as well as perineural tumour seen in epidural lymphoma. This rare condition has been reported mainly in oncology literature. Imaging features of solitary nerve involvement mimics, among others, peripheral nerve sheath tumours. We present the MRI and (18) fluorodeoxyglucose positron emission tomography ((18) FDG-PET) features of three cases of NL. MRI demonstrated variable appearances: infiltrative mass displacing neural fascicles, diffuse thickening and enhancement, and thickening of individual neural fascicles. (18) FDG-PET demonstrated avid uptake in all cases, two of which revealed skip lesions of the same nerve. The diagnosis of NL was confirmed by uncomplicated CT-guided biopsy of the affected sciatic nerve in one patient.
authors.affiliation: Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: Anthony Tien Hoe
authors.identifier: http://orcid.org/0000-0001-6694-5398
authors.initials: AT
authors.lastname: Lim
authors.affiliation: Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: Danielle
authors.initials: D
authors.lastname: Clucas
authors.affiliation: Department of Anatomical Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: Christine
authors.initials: C
authors.lastname: Khoo
authors.affiliation: Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: Bimal Kumar
authors.initials: BK
authors.lastname: Parameswaran
authors.affiliation: Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.|Department of Radiology, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Eddie
authors.initials: E
authors.lastname: Lau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008380:Marek Disease / Q000000981:diagnostic imaging*; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: MRI; lymphoma; neurolymphomatosis; peripheral nervous system; positron emission tomography