title: Chitosan gel formulations containing egg yolk oil and epidermal growth factor for dermal burn treatment.
abstract: In the present study chitosan based gel formulations containing Egg Yolk Oil (EYO) and Epidermal Growth Factor (EGF) were formulated successfully aiming at enhanced topical treatment of dermal burns the combination of traditional approaches with modern drug delivery systems. Physicochemical properties of the formulations were analyzed and efficacy of the formulations prepared were evaluated versus a commercial product; Silverdin (1% silver sulfadiazine) in vivo on Wistar rats. Burns were generated on the back of the rats and at predetermined time intervals tissue samples were collected and evaluated histologically. The analyses showed that chitosan based gel formulations containing Egg Yolk Oil (E1) and chitosan based gel formulations containing EYO and EGF (M1) formulations seem to be better alternatives for Silverdin with a significant difference (p < 0.05) considering healing ranks of tissue samples.
authors.forename: E
authors.initials: E
authors.lastname: Yenilmez
authors.forename: E
authors.initials: E
authors.lastname: Başaran
authors.forename: R
authors.initials: R
authors.lastname: Arslan
authors.forename: M S
authors.initials: MS
authors.lastname: Berkman
authors.forename: U M
authors.initials: UM
authors.lastname: Güven
authors.forename: C
authors.initials: C
authors.lastname: Bayçu
authors.forename: Y
authors.initials: Y
authors.lastname: Yazan
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry* / Q000627:therapeutic use*; D004355:Drug Stability; D004530:Egg Yolk / Q000737:chemistry*; D004815:Epidermal Growth Factor / Q000737:chemistry* / Q000627:therapeutic use*; D005260:Female; D005782:Gels; D006863:Hydrogen-Ion Concentration; D051381:Rats; D017208:Rats, Wistar; D012212:Rheology; D013411:Sulfadiazine / Q000008:administration & dosage / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D005782:Gels; D013411:Sulfadiazine; D004815:Epidermal Growth Factor; D048271:Chitosan