title: Carbohydrate-rich breakfast attenuates glycaemic, insulinaemic and ghrelin response to ad libitum lunch relative to morning fasting in lean adults.
abstract: Breakfast omission is associated with obesity and CVD/diabetes, but the acute effects of extended morning fasting upon subsequent energy intake and metabolic/hormonal responses have received less attention. In a randomised cross-over design, thirty-five lean men (n 14) and women (n 21) extended their overnight fast or ingested a typical carbohydrate-rich breakfast in quantities relative to RMR (i.e. 1963 (sd 238) kJ), before an ad libitum lunch 3 h later. Blood samples were obtained hourly throughout the day until 3 h post-lunch, with subjective appetite measures assessed. Lunch intake was greater following extended fasting (640 (sd 1042) kJ, P< 0.01) but incompletely compensated for the omitted breakfast, with total intake lower than the breakfast trial (3887 (sd 1326) v. 5213 (sd 1590) kJ, P< 0.001). Systemic concentrations of peptide tyrosine-tyrosine and leptin were greater during the afternoon following breakfast (both P< 0.05) but neither acylated/total ghrelin concentrations were suppressed by the ad libitum lunch in the breakfast trial, remaining greater than the morning fasting trial throughout the afternoon (all P< 0.05). Insulin concentrations were greater during the afternoon in the morning fasting trial (all P< 0.01). There were no differences between trials in subjective appetite during the afternoon. In conclusion, morning fasting caused incomplete energy compensation at an ad libitum lunch. Breakfast increased some anorectic hormones during the afternoon but paradoxically abolished ghrelin suppression by the second meal. Extending morning fasting until lunch altered subsequent metabolic and hormonal responses but without greater appetite during the afternoon. The present study clarifies the impact of acute breakfast omission and adds novel insights into second-meal metabolism.
authors.affiliation: Department for Health,University of Bath,BathBA2 7AY,UK.
authors.forename: Enhad A
authors.initials: EA
authors.lastname: Chowdhury
authors.affiliation: Department for Health,University of Bath,BathBA2 7AY,UK.
authors.forename: Judith D
authors.initials: JD
authors.lastname: Richardson
authors.affiliation: School of Life Sciences, Queen's Medical Centre, University of Nottingham,Nottingham,UK.
authors.forename: Kostas
authors.initials: K
authors.lastname: Tsintzas
authors.affiliation: Department for Health,University of Bath,BathBA2 7AY,UK.
authors.forename: Dylan
authors.initials: D
authors.lastname: Thompson
authors.affiliation: Department for Health,University of Bath,BathBA2 7AY,UK.
authors.forename: James A
authors.initials: JA
authors.lastname: Betts
mesh_terms: D000328:Adult; D001066:Appetite / Q000502:physiology; D001786:Blood Glucose / Q000032:analysis*; D062408:Breakfast / Q000502:physiology; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004151:Dipeptides; D002149:Energy Intake; D005215:Fasting / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D054439:Ghrelin / Q000097:blood*; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D038321:Glycemic Index; D006801:Humans; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood; D062409:Lunch / Q000502:physiology; D008297:Male; D062407:Meals / Q000502:physiology*; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004151:Dipeptides; D005230:Fatty Acids, Nonesterified; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; C042696:tyrosyltyrosine; D052216:Glucagon-Like Peptide 1
keywords: Appetite hormones; Breakfast skipping; Energy intake; Insulin sensitivity; Second-meal effect