title: How mitochondrial dynamism orchestrates mitophagy.
abstract: Mitochondria are highly dynamic, except in adult cardiomyocytes. Yet, the fission and fusion-promoting proteins that mediate mitochondrial dynamism are highly expressed in, and essential to the normal functioning of, hearts. Here, we review accumulating evidence supporting important roles for mitochondrial fission and fusion in cardiac mitochondrial quality control, focusing on the PTEN-induced putative kinase 1-Parkin mitophagy pathway. Based in part on recent findings from in vivo mouse models in which mitofusin-mediated mitochondrial fusion or dynamin-related protein 1-mediated mitochondrial fission was conditionally interrupted in cardiac myocytes, we propose several new concepts that may provide insight into the cardiac mitochondrial dynamism-mitophagy interactome.
authors.affiliation: From the Department of Medicine, Evans Center, Boston University School of Medicine, MA (O.S.S.); Department of Biochemistry, Ben Gurion University of the Negev, Beer Sheva, Israel (O.S.S.); and Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (M.S., G.W.D.).
authors.forename: Orian S
authors.initials: OS
authors.lastname: Shirihai
authors.affiliation: From the Department of Medicine, Evans Center, Boston University School of Medicine, MA (O.S.S.); Department of Biochemistry, Ben Gurion University of the Negev, Beer Sheva, Israel (O.S.S.); and Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (M.S., G.W.D.).
authors.forename: Moshi
authors.initials: M
authors.lastname: Song
authors.affiliation: From the Department of Medicine, Evans Center, Boston University School of Medicine, MA (O.S.S.); Department of Biochemistry, Ben Gurion University of the Negev, Beer Sheva, Israel (O.S.S.); and Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (M.S., G.W.D.). gdorn@dom.wustl.edu.
authors.forename: Gerald W
authors.initials: GW
authors.lastname: Dorn
mesh_terms: D000818:Animals; D034281:Dynamins / Q000378:metabolism; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D063306:Mitophagy; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D000099202:PTEN-Induced Putative Kinase
chemical_list: D034281:Dynamins; D011494:Protein Kinases; D044767:Ubiquitin-Protein Ligases; D000099202:PTEN-Induced Putative Kinase; C111567:parkin protein
keywords: Parkinson disease; autophagy; mitochondria; mitochondrial dynamics