title: Vaccine coverage in CF children: A French multicenter study.
abstract: BACKGROUND
  Recent reports have pointed the low vaccine coverage in patients with chronic diseases. Data are lacking in patients with cystic fibrosis (CF). Gaining more information on coverage both for mandatory vaccines and those more specifically recommended would help to optimize care of these patients.
  
  
  METHODS
  Data were extracted from the "MucoFlu" study, which was a prospective study performed in 2009 in the 5 cystic fibrosis centers of the Paris metropolitan area. Data on mandatory and recommended vaccines in CF were collected in the health booklet and compared to the coverage of the general population.
  
  
  RESULTS
  A total of 134 CF children were included. Vaccination coverage for mandatory vaccines was insufficient (DTPCaHi, conjugate pneumococcal, BCG, MMR and hepatitis B) at 1year of age with no catching-up with age in contrast to the general population. Approximately 66% of the children had immunization for seasonal influenza and 91% for 2009 pandemic flu. Coverage for vaccines specifically recommended in CF was low for hepatitis A, non conjugate pneumococcal and varicella.
  
  
  CONCLUSIONS
  This study shows a defect in vaccine coverage for both routine immunization and vaccines more specifically recommended in CF.
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie-Allergologie Pédiatrique et Centre de Ressources et de Compétences en Mucoviscidose, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Masson
authors.affiliation: Inserm CIC 1417, Paris, France; Université Paris Descartes, Paris Sorbonne Cite, Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Launay
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Robert Debré, Centre de Ressources et de Compétences en Mucoviscidose, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Delaisi
authors.affiliation: Centre Hospitalier Intercommunal de Créteil, Centre de Ressources et de Compétences en Mucoviscidose, Créteil, France.
authors.forename: L
authors.initials: L
authors.lastname: Bassinet
authors.affiliation: Centre Hospitalier Intercommunal de Créteil, Centre de Ressources et de Compétences en Mucoviscidose, Créteil, France.
authors.forename: N
authors.initials: N
authors.lastname: Remus
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie-Allergologie Pédiatrique et Centre de Ressources et de Compétences en Mucoviscidose, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Lebourgeois
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie-Allergologie Pédiatrique et Centre de Ressources et de Compétences en Mucoviscidose, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Chedevergne
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie-Allergologie Pédiatrique et Centre de Ressources et de Compétences en Mucoviscidose, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bailly
authors.affiliation: Hôpital Mignot, Centre de Ressources et de Compétences en Mucoviscidose, Versailles, France.
authors.forename: P
authors.initials: P
authors.lastname: Foucaud
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Trousseau, Centre de Ressources et de Compétences en Mucoviscidose, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Corvol
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie-Allergologie Pédiatrique et Centre de Ressources et de Compétences en Mucoviscidose, Paris, France; Université Paris Descartes, Paris Sorbonne Cite, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: deBlic
authors.affiliation: Assistance-Publique Hôpitaux de Paris, Hôpital Necker, Service de Pneumologie-Allergologie Pédiatrique et Centre de Ressources et de Compétences en Mucoviscidose, Paris, France; Université Paris Descartes, Paris Sorbonne Cite, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Sermet-Gaudelus
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D011446:Prospective Studies; D014611:Vaccination / Q000706:statistics & numerical data*; D014765:Viral Vaccines / Q000494:pharmacology*; D014777:Virus Diseases / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D014765:Viral Vaccines
keywords: Cystic fibrosis; Hepatitis B; Immunization; Influenza; Vaccine coverage