title: Metabolism and oxidative stress response pathways in kidney cancer: a tale of chance and necessity.
abstract: Over 270,000 patients are affected with kidney cancer worldwide and 120,000 died from this disease in 2014. Over the last few decades, important progress has been made in our understanding of the genetic and molecular mechanisms underlying the growth of these tumors, which has led to improvement in patient care. Some of the most significant recent advances came from the increasing number of large datasets generated by bioinformatics (genomics, proteomics, etc.) and their integration to characterize the genetic and molecular factors responsible for kidney tumor development and survival. Interestingly, deregulated metabolism and oxidative stress pathways are commonly found in advanced-stage kidney tumors and are important factors to consider and potentially target when developing therapeutic approaches.
authors.affiliation: From the Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute at the National Institutes of Health, Bethesda, MD.
authors.forename: Carole
authors.initials: C
authors.lastname: Sourbier
authors.affiliation: From the Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute at the National Institutes of Health, Bethesda, MD.
authors.forename: Ramaprasad
authors.initials: R
authors.lastname: Srinivasan
authors.affiliation: From the Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute at the National Institutes of Health, Bethesda, MD.
authors.forename: W Marston
authors.initials: WM
authors.lastname: Linehan
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000378:metabolism; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D058990:Molecular Targeted Therapy; D018384:Oxidative Stress
chemical_list: D000970:Antineoplastic Agents