title: Concomitant chemoradiotherapy for advanced squamous cell carcinoma of the temporal bone.
abstract: The purpose of this study was to analyze outcomes for the treatment of locally advanced temporal bone cancer by means of concomitant chemoradiotherapy (CCRT) with a combination of cisplatin (CDDP), 5-fluorouracil (5-FU), and docetaxel (TPF).
  
  
  
  Between 2006 and 2011, 34 patients with squamous cell carcinoma of the temporal bone were treated at Kobe University Hospital. Medical records were retrospectively reviewed to obtain information concerning patient characteristics, extent of disease, treatment, adverse events, and oncologic results.
  
  
  
  Ten patients were treated with CCRT using TPF regimen. The 5-year overall survival rate and disease-free survival rate were both 60%. Of special interest is that even for patients with unresectable T4 disease, the 5-year overall survival rate was 56%.
  
  
  
  The results of our study indicate that CCRT with TPF for locally advanced temporal bone cancer is an effective and promising regimen. © 2015 Wiley Periodicals, Inc. Head Neck 38: E949-E953, 2016.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Shinomiya
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Hasegawa
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamashita
authors.affiliation: Department of Radiation Oncology, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ejima
authors.affiliation: Department of Radiation Oncology, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Yoshida
authors.initials: Y
authors.lastname: Kenji
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Otsuki
authors.affiliation: Department of Medical Oncology/Hematology, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Kiyota
authors.affiliation: Department of Plastic Surgery, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Sakakibara
authors.affiliation: Department of Plastic Surgery, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nomura
authors.affiliation: Department of Plastic Surgery, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Hashikawa
authors.affiliation: Department of Neurosurgery, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Kohmura
authors.affiliation: Department of Radiation Oncology, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Sasaki
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Chuo-Ku, Kobe, Hyogo, Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Nibu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006258:Head and Neck Neoplasms / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D043823:Taxoids / Q000627:therapeutic use; D013701:Temporal Bone / Q000473:pathology*
chemical_list: D043823:Taxoids; D002945:Cisplatin; D005472:Fluorouracil
keywords: cisplatin; concomitant chemoradiotherapy; docetaxel; ear cancer; temporal bone