title: [Efficacy of a medical device containing liposomal hyaluronic acid against vulvo-vaginal dryness].
abstract: OBJECTIVE
  Hyaluronic acid (HA) is present in the vulval and vaginal conjonctive tissue. It possesses hydrating and healing properties and is indicated to treat menopause induced vulvo-vaginal atrophy. The goal of this study is to evaluate the efficacy of a medical device containing liposomal HA upon patients of different ages suffering from vulvo-vaginal dryness (VVD).
  
  
  METHODS
  Tested product Mucogyne® was applied 3 times a week for 84 days by 47 patients, 28 premenopausal young women (mean age: 32 years old) and 19 post-menopausal women (mean age: 57.5 years old) all suffering from VVD associated to spontaneous pain and dyspareunia. Clinical evaluations and Vaginal Health Index (VHS) were calculated at 0, 1 and 3 months.
  
  
  RESULTS
  A significant clinical improvement (P<0.001) occurred at 1 month (-25 % for dryness and -46 % for pain) and at 3 months (respectively -86 and -79 %). VHS was significantly improved (P<0.001) from 30 % at 1 month to 72 % after 3 months.
  
  
  CONCLUSIONS
  Liposomal AH significantly decreases symptoms and clinical signs of VVD at all ages and represents a safe and efficient alternative to topical and/or systemic hormonal therapy after menopause.
authors.affiliation: Institut Alfred-Fournier, 25, boulevard Saint-Jacques, 75014 Paris, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Bohbot
authors.affiliation: Institut Alfred-Fournier, 25, boulevard Saint-Jacques, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: de Belilovsky
authors.affiliation: Iprad Pharma, 174, quai de Jemmapes, 75010 Paris, France. Electronic address: g.brami@iprad-labo.com.
authors.forename: G
authors.initials: G
authors.lastname: Brami
authors.affiliation: Service de gynécologie-obstétrique, CHRU de Nîmes, place du Professeur-Robert-Debré, 30029 Nîmes, France.
authors.forename: P
authors.initials: P
authors.lastname: Mares
mesh_terms: D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy / Q000628:therapy; D004414:Dyspareunia / Q000628:therapy*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D008875:Middle Aged; D011446:Prospective Studies; D014621:Vagina / Q000473:pathology; D055675:Viscosupplements / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D055675:Viscosupplements; D006820:Hyaluronic Acid
keywords: Acide hyaluronique liposomé; Atrophie vulvo-vaginale; Hyaluronic acid; Liposomal; Mucogyne(®); Sécheresse vulvo-vaginale; Vulvo-vaginal atrophy; Vulvo-vaginal dryness