title: Omentin Polymorphism and its Relations to Bone Mineral Density in Women.
abstract: OBJECTIVE
  Recognition of different genetic variants underlying development of osteoporosis would make it possible to administer individual symptomatic treatment as well as early prophylactics of osteoporosis. The aim of the study was to evaluate frequency of polymorphism 326A/T of gene ITLN-1 and assessment of its relations with the clinical parameters of osseous turnover and degree of postmenopausal osteoporosis.
  
  
  METHODS
  The study included 800 women at the postmenopausal (505) and reproductive (295) age throughout Wielkopolska region in Poland. The postmenopausal group included women with osteoporosis and osteopenia and the healthy ones. Women at the reproductive age were healthy. Frequency of the tested gene polymorphism was evaluated in the group where BMD was marked and in the control group.
  
  
  RESULTS
  The analysis of the polymorphism A326T of gene ITLN-1 showed that in healthy postmenopausal female with genotype AA birth weight, BMD L2-L4 YA (%) and BMD L2-L4 AM (%) were significantly higher (BMD-bone mineral density; L2-L4-- lumbar vertebrae no 2, 4; YA--peak adult bone mass; AM--age-matched bone mass). In women with osteopenia BMD L2-L4 YA (%) and BMD L2-L4 AM (%) were significantly higher in women with genotype AA, but BMD L2-L4 was significantly higher in women with genotype TT. In women with osteoporosis with genotype AA T-score was significantly higher, but BMD L2-L4 and BMD L2-L4 YA (%) were significantly lower in this group. BMD L2-L4 AM (%) was significantly higher in women with AA genotype.
  
  
  CONCLUSIONS
  In women with osteoporosis and osteopenia homozygous AA genotype may predispose to lower BMD in the lumbar spine.
authors.affiliation: Department of Histology and Embriology, Medical University of Silesia, Zabrze, Poland. Electronic address: metabolizm.db@gmail.com.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Boron
authors.affiliation: Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University, Szczecin, Poland; Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants, Poznan, Poland.
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Czerny
authors.affiliation: Laboratory of Experimental Pharmacogenetics, Department of Clinical Pharmacy and Biopharmacy, University of Medical Sciences, Poznan, Poland; Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants, Poznan, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Bartkowiak-Wieczorek
authors.affiliation: Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland.
authors.forename: Dominik
authors.initials: D
authors.lastname: Sieron
authors.affiliation: Division of Obstetrics and Gynecology, Podhalanski Multidisciplinary Hospital Nowy Targ, Nowy Targ, Poland.
authors.forename: Hubert
authors.initials: H
authors.lastname: Wolski
mesh_terms: D000328:Adult; D015519:Bone Density / Q000235:genetics*; D001851:Bone Diseases, Metabolic / Q000235:genetics; D016723:Bone Remodeling / Q000235:genetics; D016207:Cytokines / Q000235:genetics*; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics; D005838:Genotype; D006801:Humans; D037102:Lectins / Q000235:genetics*; D008159:Lumbar Vertebrae; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics*; D015663:Osteoporosis, Postmenopausal / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins
keywords: Age; Gene ITLN-1 — Intelectin-1 (intestinal lectin omentin); Osteoporosis; Polymorphism; Women