title: Synthesis of fluorosugar reagents for the construction of well-defined fluoroglycoproteins.
abstract: 2-Deoxy-2-fluoroglycosyl iodides are privileged glycosyl donors for the stereoselective preparation of 1-Nu-β-fluorosugars, which are useful reagents for chemical site-selective protein glycosylation. Ready access to such β-fluorosugars enables the mild and efficient construction of well-defined fluoroglycoproteins.
authors.affiliation: †Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, C/Marcel·lí Domingo s/n, 43007 Tarragona, Spain.
authors.forename: Míriam
authors.initials: M
authors.lastname: Salvadó
authors.affiliation: ‡Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Amgarten
authors.affiliation: †Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, C/Marcel·lí Domingo s/n, 43007 Tarragona, Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Castillón
authors.affiliation: ‡Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K.|§Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
authors.forename: Gonçalo J L
authors.initials: GJ
authors.lastname: Bernardes
authors.affiliation: †Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, C/Marcel·lí Domingo s/n, 43007 Tarragona, Spain.
authors.forename: Omar
authors.initials: O
authors.lastname: Boutureira
mesh_terms: D006023:Glycoproteins / Q000138:chemical synthesis* / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D006023:Glycoproteins; D006027:Glycosides; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents