title: Cerebrospinal fluid CXCL13 in clinically isolated syndrome patients: Association with oligoclonal IgM bands and prediction of Multiple Sclerosis diagnosis.
abstract: Cerebrospinal fluid (CSF) CXCL13 was shown to correlate with markers of intrathecal inflammation and CSF oligoclonal IgM bands (IgMOB) have been associated with a more severe Multiple Sclerosis (MS) course. We correlated CSF CXCL13 levels with clinical, MRI and CSF parameters, including CSF IgMOB, in 110 Clinically Isolated Syndrome (CIS) patients. CSF CXCL13 levels correlated with CSF cell count, total protein, IgG Index and with the presence of CSF IgGOB and IgMOB. CSF CXCL13 levels ≥15.4 pg/ml showed a good positive predictive value and specificity for a MS diagnosis and for a clinical relapse within one year from onset.
authors.affiliation: Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: perdiana@tin.it.
authors.forename: Diana
authors.initials: D
authors.lastname: Ferraro
authors.affiliation: Neuroimmunology Laboratory, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: veri1986@yahoo.it.
authors.forename: Veronica
authors.initials: V
authors.lastname: Galli
authors.affiliation: Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: fravi79@gmail.com.
authors.forename: Francesca
authors.initials: F
authors.lastname: Vitetta
authors.affiliation: Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: annamariasimone@gmail.com.
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Simone
authors.affiliation: Neuroimmunology Laboratory, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: r.bedin@ausl.mo.it.
authors.forename: Roberta
authors.initials: R
authors.lastname: Bedin
authors.affiliation: Department of Diagnostic and Clinical Medicine and Public Health, University of Modena and Reggio Emilia, Via del Pozzo, 70, 41100 Modena, Italy. Electronic address: cinzia.delgiovane@unimore.it.
authors.forename: Cinzia
authors.initials: C
authors.lastname: Del Giovane
authors.affiliation: Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: franca.morselli@gmail.com.
authors.forename: Franca
authors.initials: F
authors.lastname: Morselli
authors.affiliation: Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: maddyfilippini@gmail.com.
authors.forename: Maria Maddalena
authors.initials: MM
authors.lastname: Filippini
authors.affiliation: Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: nichelli@unimo.it.
authors.forename: Paolo Frigio
authors.initials: PF
authors.lastname: Nichelli
authors.affiliation: Neurology Unit, Department of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Via Pietro Giardini, 1355, 41126 Modena, Italy. Electronic address: p.sola@ausl.mo.it.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Sola
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D054382:Chemokine CXCL13 / Q000097:blood / Q000134:cerebrospinal fluid*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000276:immunology; D043025:Oligoclonal Bands / Q000097:blood / Q000134:cerebrospinal fluid*; D011237:Predictive Value of Tests; D012008:Recurrence; D012307:Risk Factors; D013116:Spinal Cord / Q000473:pathology; D055815:Young Adult
chemical_list: C110663:CXCL13 protein, human; D054382:Chemokine CXCL13; D043025:Oligoclonal Bands
keywords: CXCL13; Cerebrospinal fluid; Clinically Isolated Syndrome; IgM oligoclonal bands; Multiple Sclerosis; Relapsing–remitting