title: Synergistic action of octopamine receptor agonists on the activity of selected novel insecticides for control of dengue vector Aedes aegypti (Diptera: Culicidae) mosquito.
abstract: Studying insecticide resistance in mosquitoes has attracted the attention of many scientists to elucidate the pathways of resistance development and to design novel strategies in order to prevent or minimize the spread and evolution of resistance. Here, we tested the synergistic action of piperonyl butoxide (PBO) and two octopamine receptor (OR) agonists, amitraz (AMZ) and chlordimeform (CDM) on selected novel insecticides to increase their lethal action on the fourth instar larvae of Aedes aegypti L. However, chlorfenapyr was the most toxic insecticide (LC50 = 193, 102, and 48 ng/ml, after 24, 48, and 72 h exposure, respectively) tested. Further, PBO synergized all insecticides and the most toxic combinatorial insecticide was nitenpyram even after 48 and 72 h exposure. In addition, OR agonists significantly synergized most of the selected insecticides especially after 48 and 72 h exposure. The results imply that the synergistic effects of amitraz are a promising approach in increasing the potency of certain insecticides in controlling the dengue vector Ae. aegypti mosquito.
authors.affiliation: Plant Protection Department, Faculty of Agriculture, Assiut University, Assiut 71526, Egypt; Center for Health and the Environment, University of California Davis, Davis, CA 95616, USA.
authors.forename: Mohamed Ahmed Ibrahim
authors.initials: MA
authors.lastname: Ahmed
authors.affiliation: Center for Health and the Environment, University of California Davis, Davis, CA 95616, USA; Environmental Toxicology Department, University of California Davis, Davis, CA 95616, USA. Electronic address: cfvogel@ucdavis.edu.
authors.forename: Christoph Franz Adam
authors.initials: CF
authors.lastname: Vogel
mesh_terms: D000330:Aedes / Q000187:drug effects; D000818:Animals; D002742:Chlorphenamidine / Q000494:pharmacology*; D003715:Dengue; D007306:Insecticides / Q000633:toxicity*; D007814:Larva / Q000187:drug effects; D010574:Pesticide Synergists / Q000494:pharmacology*; D010882:Piperonyl Butoxide / Q000494:pharmacology*; D017982:Receptors, Biogenic Amine / Q000819:agonists*; D014052:Toluidines / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D010574:Pesticide Synergists; D017982:Receptors, Biogenic Amine; D014052:Toluidines; C027604:norsynephrine receptor; C014983:amitraz; D002742:Chlorphenamidine; D010882:Piperonyl Butoxide
keywords: Aedes aegypti; IGRs; Insecticide resistance; Neonicotinoids; Octopamine receptor agonists