title: Secretion systems in Gram-negative bacteria: structural and mechanistic insights.
abstract: Bacteria have evolved a remarkable array of sophisticated nanomachines to export various virulence factors across the bacterial cell envelope. In recent years, considerable progress has been made towards elucidating the structural and molecular mechanisms of the six secretion systems (types I-VI) of Gram-negative bacteria, the unique mycobacterial type VII secretion system, the chaperone-usher pathway and the curli secretion machinery. These advances have greatly enhanced our understanding of the complex mechanisms that these macromolecular structures use to deliver proteins and DNA into the extracellular environment or into target cells. In this Review, we explore the structural and mechanistic relationships between these single- and double-membrane-embedded systems, and we briefly discuss how this knowledge can be exploited for the development of new antimicrobial strategies.
authors.affiliation: Institute of Structural and Molecular Biology, University College London and Birkbeck, Malet Street, London WC1E 7HX, UK.
authors.forename: Tiago R D
authors.initials: TR
authors.lastname: Costa
authors.affiliation: 1] Institute of Structural and Molecular Biology, University College London and Birkbeck, Malet Street, London WC1E 7HX, UK. [2].
authors.forename: Catarina
authors.initials: C
authors.lastname: Felisberto-Rodrigues
authors.affiliation: 1] Institute of Structural and Molecular Biology, University College London and Birkbeck, Malet Street, London WC1E 7HX, UK. [2].
authors.forename: Amit
authors.initials: A
authors.lastname: Meir
authors.affiliation: 1] Institute of Structural and Molecular Biology, University College London and Birkbeck, Malet Street, London WC1E 7HX, UK. [2].
authors.forename: Marie S
authors.initials: MS
authors.lastname: Prevost
authors.affiliation: 1] Institute of Structural and Molecular Biology, University College London and Birkbeck, Malet Street, London WC1E 7HX, UK. [2].
authors.forename: Adam
authors.initials: A
authors.lastname: Redzej
authors.affiliation: 1] Institute of Structural and Molecular Biology, University College London and Birkbeck, Malet Street, London WC1E 7HX, UK. [2].
authors.forename: Martina
authors.initials: M
authors.lastname: Trokter
authors.affiliation: Institute of Structural and Molecular Biology, University College London and Birkbeck, Malet Street, London WC1E 7HX, UK.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Waksman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D058947:Bacterial Secretion Systems / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology* / Q000648:ultrastructure; D010861:Fimbriae, Bacterial / Q000502:physiology* / Q000648:ultrastructure; D006090:Gram-Negative Bacteria / Q000502:physiology* / Q000648:ultrastructure; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D018832:Molecular Chaperones / Q000502:physiology*; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D058947:Bacterial Secretion Systems; D018832:Molecular Chaperones; D037521:Virulence Factors