title: Hyperpolarized 83Kr magnetic resonance imaging of alveolar degradation in a rat model of emphysema.
abstract: Hyperpolarized (83)Kr surface quadrupolar relaxation (SQUARE) generates MRI contrast that was previously shown to correlate with surface-to-volume ratios in porous model surface systems. The underlying physics of SQUARE contrast is conceptually different from any other current MRI methodology as the method uses the nuclear electric properties of the spin I = 9/2 isotope (83)Kr. To explore the usage of this non-radioactive isotope for pulmonary pathophysiology, MRI SQUARE contrast was acquired in excised rat lungs obtained from an elastase-induced model of emphysema. A significant (83)Kr T1 relaxation time increase in the SQUARE contrast was found in the elastase-treated lungs compared with the baseline data from control lungs. The SQUARE contrast suggests a reduction in pulmonary surface-to-volume ratio in the emphysema model that was validated by histology. The finding supports usage of (83)Kr SQUARE as a new biomarker for surface-to-volume ratio changes in emphysema.
authors.affiliation: Sir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
authors.forename: David M L
authors.initials: DM
authors.lastname: Lilburn
authors.affiliation: Sir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
authors.forename: Clémentine
authors.initials: C
authors.lastname: Lesbats
authors.affiliation: Sir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Six
authors.affiliation: Respiratory Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
authors.forename: Eric
authors.initials: E
authors.lastname: Dubuis
authors.affiliation: Respiratory Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
authors.forename: Liang
authors.initials: L
authors.lastname: Yew-Booth
authors.affiliation: City Hospital Nottingham, Nottingham Respiratory Research Unit, Nottingham NG5 1PB, UK.
authors.forename: Dominick E
authors.initials: DE
authors.lastname: Shaw
authors.affiliation: Respiratory Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Belvisi
authors.affiliation: Respiratory Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Birrell
authors.affiliation: Sir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
authors.forename: Galina E
authors.initials: GE
authors.lastname: Pavlovskaya
authors.affiliation: Sir Peter Mansfield Imaging Centre, Division for Respiratory Medicine, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK thomas.meersmann@nottingham.ac.uk.
authors.forename: Thomas
authors.initials: T
authors.lastname: Meersmann
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D004195:Disease Models, Animal; D007726:Krypton / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D008962:Models, Theoretical; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging*; D011656:Pulmonary Emphysema / Q000139:chemically induced / Q000000981:diagnostic imaging*; D011859:Radiography; D051381:Rats
chemical_list: D003287:Contrast Media; D007726:Krypton
keywords: animal model emphysema; hyperpolarized noble gas MRI; krypton-83; nuclear electric quadrupolar relaxation; pulmonary imaging; surface-sensitive contrast