title: Metronidazole induced encephalopathy with peripheral polyneuropathy in patient with spinal cord injury.
abstract: Metronidazole may produce a number of neurologic side effects including peripheral neuropathy, seizure, encephalopathy. We experienced neurological side effects of metronidazole. The 32-year-old female patient with spinal cord injury was diagnosed as encephalophathy and peripheral polyneuropathy resulting from complication of metronidazole. It was difficult to diagnose at first glance using clinical findings because of paraplegia due to spinal cord injury. But through magnetic resonance imaging with diffusion weighted imaging and electrophysiologic study, the patient showed to have characteristic abnormalities that of a person suffering from metronidazole-induced encephalopathy and peripheral polyneuropathy. Whether the symptoms were caused by a peripheral nerve lesion or MIE, the patient's paraplegia prevented to appear other symptoms, such as ataxic gait and seizure, from manifesting. In such case as this, an active differentiated diagnosis is crucial.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kosin University College of Medicine, Busan, Korea.
authors.forename: Gi Hoon
authors.initials: GH
authors.lastname: Hwang
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kosin University College of Medicine, Busan, Korea.
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Sim
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kosin University College of Medicine, Busan, Korea.
authors.forename: Ho Joong
authors.initials: HJ
authors.lastname: Jeong
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kosin University College of Medicine, Busan, Korea.
authors.forename: Ghi Chan
authors.initials: GC
authors.lastname: Kim
authors.affiliation: Department of Physical Medicine and Rehabilitation, Kosin University College of Medicine, Busan, Korea.
authors.forename: Bae Wook
authors.initials: BW
authors.lastname: Sin
authors.affiliation: Department of Neurosurgery, Kosin University College of Medicine, Busan, Korea.
authors.forename: Ju Ho
authors.initials: JH
authors.lastname: Jung
keywords: Encephalopathy; Metronidazole; Spinal cord injury