title: Potential antibacterial activity of coumarin and coumarin-3-acetic acid derivatives.
abstract: Coumarin and coumarin-3-acetic acid derivatives were synthesized by reacting phenols with malic acid, ethyl acetoacetate and ethyl acetylsuccinate in appropriate reaction conditions. All synthesized compounds were subjected to test for their antimicrobial activities against variety of gram positive (Bacillus subtilis, Staphylococcus aureus) and gram negative bacterial stains (Shigella sonnei, Escherichia coli) by agar dilution method. Several of them exhibited appreciable good antibacterial activity against the different strains of gram positive and gram negative bacteria. These findings suggest a great potential of these compounds for screening and use as antibacterial agents for further studies with a battery of bacteria.
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
authors.forename: Fauzia Anjum
authors.initials: FA
authors.lastname: Chattha
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
authors.forename: Munawar Ali
authors.initials: MA
authors.lastname: Munawar
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
authors.forename: Mehrun
authors.initials: M
authors.lastname: Nisa
authors.affiliation: Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ashraf
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
authors.forename: Samina
authors.initials: S
authors.lastname: Kousar
authors.affiliation: College of Conventional Medicine, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: Shafia
authors.initials: S
authors.lastname: Arshad
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects*; D003374:Coumarins / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D012764:Shigella sonnei / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000085:Acetates; D000900:Anti-Bacterial Agents; D003374:Coumarins; C030123:coumarin