title: Successful renal transplantation in Muckle-Wells syndrome treated with anti-IL-1β-monoclonal antibody.
abstract: We report the first case of a 32-year-old woman with Muckle-Wells syndrome and biopsy-proven systemic AA amyloidosis and end-stage renal disease. She was treated with canakinumab 150 mg subcutaneously every 8 weeks and underwent renal transplantation. Fourteen months after renal transplanation, the patient had no flares of Muckle-Wells syndrome and no evidence of amyloidosis in the renal transplant under an excellent graft function and therapy with canakinumab.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, University Hospital of Giessen and Marburg, Marburg, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Kortus-Götze
authors.affiliation: Department of Internal Medicine, Division of Nephrology, University Hospital of Giessen and Marburg, Marburg, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Hoyer
keywords: Muckle–Wells syndrome; amyloidosis; canakinumab; renal transplantation