title: Pseudorabies Virus Fast Axonal Transport Occurs by a pUS9-Independent Mechanism.
abstract: Reactivation from latency results in transmission of neurotropic herpesviruses from the nervous system to body surfaces, referred to as anterograde axonal trafficking. The virus-encoded protein pUS9 promotes axonal dissemination by sorting virus particles into axons, but whether it is also an effector of fast axonal transport within axons is unknown. To determine the role of pUS9 in anterograde trafficking, we analyzed the axonal transport of pseudorabies virus in the presence and absence of pUS9.
authors.affiliation: Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois, USA.
authors.forename: Gina R
authors.initials: GR
authors.lastname: Daniel
authors.affiliation: School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Sollars
authors.affiliation: School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.
authors.forename: Gary E
authors.initials: GE
authors.lastname: Pickard
authors.affiliation: Department of Microbiology-Immunology, Northwestern University, Chicago, Illinois, USA g-smith3@northwestern.edu.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Smith
mesh_terms: D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000821:virology*; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D008074:Lipoproteins / Q000235:genetics / Q000378:metabolism*; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D011557:Pseudorabies / Q000821:virology*; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D008074:Lipoproteins; D010750:Phosphoproteins; C491630:US9 protein, Suid herpesvirus 1; D014764:Viral Proteins