title: Store-operated Ca²⁺-entry and adenylyl cyclase.
abstract: One of the longest-standing effects of SOCE is in its selective regulation of Ca(2+)-sensitive adenylyl cyclase (AC) activity in non-excitable cells. Remarkably it was this source of Ca(2+) (SOCE) rather than the apparent magnitude of the Ca(2+)-rise that conferred AC responsiveness. The molecular basis for this dependence is now resolved in the case of adenylyl cyclase 8 (AC8). Sensors for Ca(2+) and cAMP targeted to ACs have been particularly useful in dissecting the influences upon and composition of what turn out to be signalling microdomains centred on ACs. A number of physiological processes depend on the regulation by SOCE of ACs, but the issue is under-studied. Here I will expand on these topics and point to some immediate unresolved questions.
authors.affiliation: Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom. Electronic address: dmfc2@cam.ac.uk.
authors.forename: Dermot M F
authors.initials: DM
authors.lastname: Cooper
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D008565:Membrane Proteins; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D002118:Calcium
keywords: Adenylyl cyclase; Calcium; Calmodulin; Orai1; SOCE; Stim1