title: The prevention of diabetes and cardiovascular disease in people with schizophrenia.
abstract: OBJECTIVE
  Primary prevention of diabetes and cardiovascular disease is an important priority for people with schizophrenia. This review aims to identify lifestyle and pharmacological interventions that reduce diabetes and cardiovascular disease in people with schizophrenia.
  
  
  METHODS
  PubMed and other electronic databases were searched to identify relevant articles.
  
  
  RESULTS
  Lifestyle interventions that focus on diet and physical activity reduce the incidence of diabetes. Similar programmes in people with schizophrenia have led to significant weight loss and may reasonably be expected to reduce diabetes in the long-term. Metformin may be considered when lifestyle change is not feasible or effective. Lifestyle interventions, particularly smoking cessation, are likely to be effective in reducing cardiovascular disease in people with schizophrenia. Although cardiovascular prevention trials with statins have not been performed in people with schizophrenia, similar reductions in cholesterol has been seen as in the general population and statins should be considered for those at high risk. Traditional cardiovascular risk prediction models perform well in identifying those at high cardiovascular risk, but bespoke prediction models using data from people with schizophrenia perform better.
  
  
  CONCLUSIONS
  Reducing diabetes and cardiovascular disease requires a coordinated and concerted effort from mental and physical health teams working across primary and secondary care.
authors.affiliation: Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
authors.forename: R I G
authors.initials: RI
authors.lastname: Holt
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000517:prevention & control*; D004032:Diet; D015444:Exercise; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D008019:Life Style; D012307:Risk Factors; D012559:Schizophrenia / Q000503:physiopathology* / Q000628:therapy*
keywords: cardiovascular disease; diabetes; prevention; schizophrenia; screening