title: [The role of adenosine Al receptors and mitochondrial K+ATP channels in the mechanism of increasing the resistance to acute hypoxia in the combined effects of hypoxia and hypercapnia].
abstract: We studied the role of the role of mitoK+ATp channels and Al-adenosine receptor in the mechanism of increasing the resistance to acute hypoxia after hypoxic, hypercapnic and hypercapnic-hypoxic preconditioning. It is shown that mitochondrial ATP-sensitive potassium channels and Al-adenosine receptors, an important mechanism of preconditioning have a high value to increase the resistance to acute hypoxia/ischemia in the combined effect of hypoxia and hypercapnia. However, with regard to the adenosine receptor, this mechanism is realized without the participation hypercapnic component, which apparently starts neuroprotection without activation of the adenosine Al receptors.
authors.forename: P P
authors.initials: PP
authors.lastname: Tregub
authors.forename: V P
authors.initials: VP
authors.lastname: Kulikov
authors.forename: L A
authors.initials: LA
authors.lastname: Stepanova
authors.forename: A S
authors.initials: AS
authors.lastname: Zabrodina
authors.forename: M E
authors.initials: ME
authors.lastname: Nagibaeva
mesh_terms: D000222:Adaptation, Physiological; D058907:Adenosine A1 Receptor Agonists / Q000494:pharmacology; D058916:Adenosine A1 Receptor Antagonists / Q000494:pharmacology; D000818:Animals; D060467:Disease Resistance; D006935:Hypercapnia / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D000860:Hypoxia / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008810:Mice, Inbred C57BL; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000819:agonists / Q000378:metabolism*; D043682:Receptor, Adenosine A1 / Q000378:metabolism*; D016019:Survival Analysis
chemical_list: D058907:Adenosine A1 Receptor Agonists; D058916:Adenosine A1 Receptor Antagonists; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D043682:Receptor, Adenosine A1; C117780:mitochondrial K(ATP) channel