title: IFN Regulatory Factor-1 Modulates the Function of Dendritic Cells in Patients with Acute Coronary Syndrome.
abstract: BACKGROUND
  Atherosclerosis is widely recognized as a complex inflammatory disease involving pathogenic immune response of T cells and antigen-presenting cells (APCs) such as dendritic cells (DCs) and macrophages. Accumulating evidence has revealed that mature DCs play critical roles in the differentiation of effector T cells into CD4+ T cells, which effectively participate in the onset of acute coronary syndrome (ACS). IFN regulatory factor (IRF)-1 has been shown to be involved in various immune processes. The role of IRF-1 in DCs in the pathogenesis of ACS has not been investigated.
  
  
  RESULTS
  We examined the relative mRNA and protein expression of IRF-1 in human monocyte-derived DCs in patients with coronary artery disease (CAD). The overexpression or silencing of IRF-1 expression in DCs in patients with ACS was performed to explore the possible role of IRF-1 in the maturation and function of DCs involved in ACS. The results showed that the relative expression of IRF-1 in DCs is obviously increased in patients with ACS. The overexpression or silencing of IRF-1 expression could effectively promote or attenuate the maturation and function of DCs. In addition, we revealed that the MAPK pathway (phosphorylation of JNK, p38 and ERK1/2) might be downstream of IRF-1 signalling pathway in activation of circulating DCs in ACS patients.
  
  
  CONCLUSIONS
  The present data demonstrate that IRF-1 could effectively promote the immune maturation and function of DCs in ACS patients.
authors.forename: Min
authors.initials: M
authors.lastname: Guo
authors.forename: Rui
authors.initials: R
authors.lastname: Yan
authors.forename: Caixia
authors.initials: C
authors.lastname: Wang
authors.forename: Hongtao
authors.initials: H
authors.lastname: Shi
authors.forename: Meng
authors.initials: M
authors.lastname: Sun
authors.forename: Shuang
authors.initials: S
authors.lastname: Guo
authors.forename: Chuanshi
authors.initials: C
authors.lastname: Xiao
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics / Q000276:immunology*; D000368:Aged; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D050856:Interferon Regulatory Factor-1 / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics; D015854:Up-Regulation
chemical_list: D050856:Interferon Regulatory Factor-1; D012333:RNA, Messenger