title: Anti-tumor activity of verbascoside loaded gold nanoparticles.
abstract: Verbascoside (VB), a major bioactive constituent of the Tsoong herb, has attracted a great deal of attention due to its pharmacological properties. In this study, we demonstrated the inhibitory effect of VB-loaded gold nanoparticles (VB-Au) on the growth of K562 cells both in vitro and in vivo. We found that, in contrast with the same concentration of gold nanoparticles (Au) or VB, VB-Au significantly decreased the viability of K562 cells and promoted the apoptosis of tumor cells. A tumor implantation mouse model further showed that the intravenous injection of VB-Au effectively inhibited the growth and induced the apoptosis of tumor cells. In conclusion, our results collectively demonstrate that VB-Au nanoparticles provide an effective strategy to control tumor cell growth.
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Heming
authors.initials: H
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Junyong
authors.initials: J
authors.lastname: Xu
authors.forename: Lei
authors.initials: L
authors.lastname: Duan
authors.forename: Caiyun
authors.initials: C
authors.lastname: Jiang
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Yuan
authors.forename: Gen
authors.initials: G
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Zeng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004058:Diffusion; D005260:Female; D005960:Glucosides / Q000008:administration & dosage* / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology*; D010316:Particle Size; D010636:Phenols / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome; D059808:Polyphenols
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D006046:Gold; D053769:Nanocapsules; D010636:Phenols; C058956:acteoside; D059808:Polyphenols