title: Inflammation and cancer: till death tears them apart.
abstract: Advances in biotechnology have enabled the collection of an immeasurable amount of information from genomic, transcriptomic, metabolomic and proteomic studies of tumours within their microenvironments. The dissection of cytokine and chemokine networks has provided new clues to the interactions between cancer cells and their surrounding inflammatory landscape. To bridge the gap between chronic inflammation and cancer, dynamic participants in the tumour microenvironment have been identified, including tumour-associated macrophages (TAMs) and regulatory T cells (Tregs). Both of these cell types are notable for their ability to cause immunosuppressive conditions and support the evasion of tumour immune surveillance. It is clear now that the tumour-promoting inflammatory environment has to be included as one of the major cancer hallmarks. This review explores the recent advances in the understanding of cancer-related inflammation and how this is being applied to comparative oncology studies in humans and domestic species, such as the dog.
authors.affiliation: The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, United Kingdom; Center for Research and Technology of Agro-Environment and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
authors.forename: T P
authors.initials: TP
authors.lastname: Raposo
authors.affiliation: The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, United Kingdom.
authors.forename: B C B
authors.initials: BC
authors.lastname: Beirão
authors.affiliation: The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, United Kingdom.
authors.forename: L Y
authors.initials: LY
authors.lastname: Pang
authors.affiliation: Center for Research and Technology of Agro-Environment and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
authors.forename: F L
authors.initials: FL
authors.lastname: Queiroga
authors.affiliation: The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, United Kingdom. Electronic address: david.argyle@ed.ac.uk.
authors.forename: D J
authors.initials: DJ
authors.lastname: Argyle
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D063646:Carcinogenesis; D007249:Inflammation / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D009361:Neoplasm Invasiveness / Q000503:physiopathology; D009362:Neoplasm Metastasis / Q000503:physiopathology; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor
keywords: Cancer; Inflammation; Macrophages; Metastasis; Stem cells; Veterinary oncology