title: Homotopic reciprocal functional connectivity between anterior human insulae.
abstract: The aim of this study was to investigate functional connectivity between right and left insulae in the human brain. We studied a patient with implanted depth electrodes for epilepsy surgery evaluation with stereotactically placed symmetric depth electrodes in both insulae. Bipolar 1 Hz electrical stimulation of the right and left posterior short gyri in the anterior insula evoked responses in the contralateral insular structures. These responses showed a latency of 8-24 ms. This report demonstrates for the first time bi-directional homotopic and heterotopic functional connectivity between right and left anterior insulae. The short latency of the evoked responses suggests mono- or oligo-synaptic connections, most likely via the corpus callosum.
authors.affiliation: Epilepsy Center, UH Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA. nuria.lacuey@uhhospitals.org.
authors.forename: Nuria
authors.initials: N
authors.lastname: Lacuey
authors.affiliation: Epilepsy Center, UH Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
authors.forename: Bilal
authors.initials: B
authors.lastname: Zonjy
authors.affiliation: Epilepsy Center, UH Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
authors.forename: Emine S
authors.initials: ES
authors.lastname: Kahriman
authors.affiliation: Epilepsy Center, UH Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Marashly
authors.affiliation: Epilepsy Center, UH Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Miller
authors.affiliation: Epilepsy Center, UH Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
authors.forename: Samden D
authors.initials: SD
authors.lastname: Lhatoo
authors.affiliation: Epilepsy Center, UH Case Medical Center, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.
authors.forename: Hans O
authors.initials: HO
authors.lastname: Lüders
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D006801:Humans
keywords: CCEP; Corpus callosum; Epilepsy; Evoked potentials; Functional connectivity; Insula