title: Nervous system Lyme disease.
abstract: Lymphocytic meningitis, cranial neuritis or radiculoneuritis occur in up to 15% of patients with untreated Borrelia burgdorferi infection. Presentations of multifocal PNS involvement can range from painful monoradiculitis to confluent mononeuropathy multiplex. Serologic testing is highly accurate after 4 to 6 weeks of infection. In CNS infection, production of anti-Bburgdorferi antibody is often demonstrable in CSF. Oral antimicrobials are microbiologically curative in virtually all patients, including acute European neuroborreliosis. Severe cases may require parenteral treatment. The fatigue and cognitive symptoms seen in some patients with extra-neurological disease are neither evidence of CNS infection nor specific to Lyme disease.
authors.affiliation: Department of Neurosciences, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07902, USA; Department of Neurology and Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: john.halperin@atlantichealth.org.
authors.forename: John J
authors.initials: JJ
authors.lastname: Halperin
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D025065:Borrelia burgdorferi / Q000302:isolation & purification; D003072:Cognition Disorders / Q000175:diagnosis / Q000382:microbiology; D003937:Diagnosis, Differential; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000175:diagnosis* / Q000188:drug therapy; D008569:Memory Disorders / Q000175:diagnosis / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Borrelia burgdorferi; Central nervous system; Garin-Bujadoux Bannwarth syndrome; Intrathecal antibody; Lyme disease; Nervous system; Neuroborreliosis; Peripheral nervous system