title: Acute and chronic toxicity of tetrabromobisphenol A to three aquatic species under different pH conditions.
abstract: Tetrabromobisphenol A (TBBPA) is a well-known brominated flame retardant. It has been detected in the environment and shows high acute toxicity to different organisms at high concentrations. In this work, the effects of pH and dimethyl sulfoxide (DMSO) on the acute toxicity of TBBPA to Daphnia magna and Limnodrilus hoffmeisteri were tested, and the oxidative stress induced by TBBPA in livers of Carassius auratus was assessed using four biomarkers. The integrated biomarker response (IBR) was applied to assess the overall antioxidant status in fish livers. Moreover, fish tissues (gills and livers) were also studied histologically. The results showed that low pH and DMSO enhanced the toxicity of TBBPA. Furthermore, changes in the activity of antioxidant enzymes and glutathione level suggested that TBBPA generates oxidative stress in fish livers. The IBR index revealed that fish exposed to 3mg/L TBBPA experienced more serious oxidative stress than exposed to acidic or alkaline conditions. The histopathological analysis revealed lesions caused by TBBPA. This study provides valuable toxicological information of TBBPA and will facilitate a deeper understanding on its potential toxicity in realistic aquatic environments.
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, PR China.
authors.forename: Qun
authors.initials: Q
authors.lastname: He
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, PR China.
authors.forename: Xinghao
authors.initials: X
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, PR China. Electronic address: sunping@nju.edu.cn.
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, PR China. Electronic address: wangzy@nju.edu.cn.
authors.forename: Zunyao
authors.initials: Z
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, PR China.
authors.forename: Liansheng
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D000845:Annelida / Q000187:drug effects*; D015415:Biomarkers / Q000032:analysis; D003621:Daphnia / Q000187:drug effects*; D005880:Gills / Q000187:drug effects; D006054:Goldfish / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D011075:Polybrominated Biphenyls / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000633:toxicity
chemical_list: D015415:Biomarkers; D011075:Polybrominated Biphenyls; D014874:Water Pollutants, Chemical; C020806:tetrabromobisphenol A
keywords: Acute toxicity; Aquatic organisms; Oxidative stress; Tetrabromobisphenol A; pH