title: Mentha suaveolens Ehrh. (Lamiaceae) Essential Oil and Its Main Constituent Piperitenone Oxide: Biological Activities and Chemistry.
abstract: Since herbal medicines play an important role in the treatment of a wide range of diseases, there is a growing need for their quality control and standardization. Mentha suaveolens Ehrh. (MS) is an aromatic herb with fruit and a spearmint flavor, used in the Mediterranean areas as a traditional medicine. It has an extensive range of biological activities, including cytotoxic, antimicrobial, antioxidant, anti-inflammatory, hypotensive and insecticidal properties, among others. This study aims to review the scientific findings and research reported to date on MS that prove many of the remarkable various biological actions, effects and some uses of this species as a source of bioactive natural compounds. On the other hand, piperitenone oxide (PO), the major chemical constituent of the carvone pathway MS essential oil, has been reported to exhibit numerous bioactivities in cells and animals. Thus, this integrated overview also surveys and interprets the present knowledge of chemistry and analysis of this oxygenated monoterpene, as well as its beneﬁcial bioactivities. Areas for future research are suggested.
authors.affiliation: Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy. mijatboz@gmail.com.
authors.forename: Mijat
authors.initials: M
authors.lastname: Božović
authors.affiliation: Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy. adele.pirolli@uniroma1.it.
authors.forename: Adele
authors.initials: A
authors.lastname: Pirolli
authors.affiliation: Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy. rino.ragno@uniroma1.it.
authors.forename: Rino
authors.initials: R
authors.lastname: Ragno
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry; D000959:Antihypertensive Agents / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry; D029001:Herbal Medicine; D007306:Insecticides / Q000737:chemistry; D008519:Medicine, Traditional; D027541:Mentha / Q000737:chemistry* / Q000145:classification; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry; D039821:Monoterpenes / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000959:Antihypertensive Agents; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D008996:Monoamine Oxidase Inhibitors; D039821:Monoterpenes; D009822:Oils, Volatile; C044956:piperitenone
keywords: Mentha suaveolens Ehrh.; biological activity; essential oil; extracts; piperitenone oxide