title: Comparison of myocardial F-18 FDG uptake between overnight and non-overnight fasting in non-diabetic healthy subjects.
abstract: OBJECTIVE
  To evaluate whether an overnight or non-overnight fast for suppressing physiological FDG uptake by the myocardium is better in non-diabetic healthy subjects before F-18 FDG PET/CT studies.
  
  
  METHODS
  One hundred two subjects who underwent whole-body F-18 FDG PET/CT for routine health checkups were retrospectively reviewed. For quantitative assessment, a region of interest was drawn around the entire left ventricle visible in the axial view containing the highest visual uptake in order to measure the maximum standardized uptake value (SUV max). FDG uptake in the myocardium was visually graded as follows: grade 0 = minimal, 1 = mostly minimal or mild, 2 = mostly intense or moderate, and 3 = homogeneously intense. Adequate suppression of myocardial uptake was quantitatively defined as a SUV max ≤ 5.0 and grade 0 by visual assessment.
  
  
  RESULTS
  With regard to the SUV max, myocardial uptake was not different between the overnight and the non-overnight fasting subjects (P = 0.753). In subjects who had adequate suppression of myocardial uptake, no significant difference was observed between the overnight and non-overnight fasting subjects either in terms of visual or quantitative assessment (P = 0.539 and P = 0.678, respectively).
  
  
  CONCLUSIONS
  Both overnight and non-overnight fasts are not adequate for suppressing the physiological uptake of FDG by the myocardium.
authors.affiliation: Department of Nuclear Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
authors.forename: Hyo Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Hyun-Yeol
authors.initials: HY
authors.lastname: Nam
authors.forename: Seong Kyu
authors.initials: SK
authors.lastname: Shin
mesh_terms: D004958:Estradiol / Q000031:analogs & derivatives; D005215:Fasting; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D019788:Fluorodeoxyglucose F18; D004958:Estradiol; C043436:16-fluoroestradiol