title: Effects of ozone pretreatment on viability of random pattern skin flaps in rats.
abstract: BACKGROUND
  Medical ozone is a chemical agent that consists of three oxygen atoms and has antioxidant, angiogenic and vasodilator effects. This study evaluated the effects of medical ozone pre-treatment on flap survival.
  
  
  METHODS
  Rats were divided into four groups of 10 rats each and a 9 × 3 cm McFarlane flap was used. Sham group: Neither surgical nor ozone pretreatment was used.
  
  
  METHODS
  No pretreatment was used after surgery. Preoperative ozone group: Preoperative 1 mg/kg ozone was given intraperitoneally for 7 days. No pretreatment was used after surgery. Postoperative ozone Group: Postoperative 1 mg/kg ozone was given intraperitoneally for 7 days. After postoperative 1 week, all groups were evaluated by surface area measurement, histopathology and electron microscopy.
  
  
  RESULTS
  With the experimental McFarlane flap model, the experimental groups had better surface area measurements, along with histopathological and electron microscopic results when compared with the control group.
  
  
  CONCLUSIONS
  Medical ozone had positive effects on flap survival due to its antioxidant, angiogenic and vasodilator qualities.
authors.affiliation: a 1 Department of Plastic, Reconstructive and Aesthetic Surgery.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Öksüz
authors.affiliation: a 1 Department of Plastic, Reconstructive and Aesthetic Surgery.
authors.forename: Serdar
authors.initials: S
authors.lastname: Yüce
authors.affiliation: a 1 Department of Plastic, Reconstructive and Aesthetic Surgery.
authors.forename: Ömer Faruk
authors.initials: ÖF
authors.lastname: Koçak
authors.affiliation: a 1 Department of Plastic, Reconstructive and Aesthetic Surgery.
authors.forename: Yasin
authors.initials: Y
authors.lastname: Canbaz
authors.affiliation: b 2 Department of Medical Histology and Embryology, Faculty of Medicine, Yüzüncü Yıl University , Van, Turkey.
authors.forename: Murat Çetin
authors.initials: MÇ
authors.lastname: Rağbetli
authors.affiliation: c 3 Department of Medical Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdoğan University , Rize, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Mercantepe
keywords: McFarlane flap; Ozone pre-treatment; flap necrosis