title: Metal-organic framework UiO-66 modified magnetite@silica core-shell magnetic microspheres for magnetic solid-phase extraction of domoic acid from shellfish samples.
abstract: Fe3O4@SiO2@UiO-66 core-shell magnetic microspheres were synthesized and characterized by transmission electron microscopy, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry, vibrating sample magnetometry, nitrogen adsorption porosimetry and zeta potential analyzer. The synthesized Fe3O4@SiO2@UiO-66 microspheres were first used for magnetic solid-phase extraction (MSPE) of domoic acid (DA) in shellfish samples. Combined with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), a fast, simple and sensitive method for the determination of DA was established successfully. Under the optimized conditions, the developed method showed short analysis time, good linearity (r(2) = 0.9990), low limit of detection (1.45 pg mL(-1); S/N = 3:1), low limit of quantification (4.82 pg mL(-1); S/N = 10:1), and good extraction repeatability (RSD ≤ 5.0%; n = 5). Real shellfish samples were processed using the developed method, and trace level of DA was detected. The results demonstrate that Fe3O4@SiO2@UiO-66 core-shell magnetic microspheres are the promising sorbents for rapid and efficient extraction of polar analytes from complex biological samples.
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
authors.forename: Wenmin
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Gao
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China; Testing Center, The Sport Science Research Center, Fuzhou University, Fuzhou, Fujian, 350002, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Tong
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China; Testing Center, The Sport Science Research Center, Fuzhou University, Fuzhou, Fujian, 350002, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, China; Testing Center, The Sport Science Research Center, Fuzhou University, Fuzhou, Fujian, 350002, China. Electronic address: zlan@fzu.edu.cn.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
mesh_terms: D002853:Chromatography, Liquid; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification; D060328:Magnetic Phenomena; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008863:Microspheres; D012758:Shellfish / Q000032:analysis*; D012822:Silicon Dioxide / Q000737:chemistry*; D052616:Solid Phase Extraction; D053719:Tandem Mass Spectrometry; D014961:X-Ray Diffraction
chemical_list: D012822:Silicon Dioxide; C012301:domoic acid; D007608:Kainic Acid; D052203:Ferrosoferric Oxide
keywords: Core–shell magnetic microsphere; Domoic acid; HPLC–MS/MS; Magnetic solid-phase extraction; Metal–organic frameworks