title: Meta-analytic connectivity and behavioral parcellation of the human cerebellum.
abstract: The cerebellum historically has been thought to mediate motor and sensory signals between the body and cerebral cortex, yet cerebellar lesions are also associated with altered cognitive behavioral performance. Neuroimaging evidence indicates that the cerebellum contributes to a wide range of cognitive, perceptual, and motor functions. Here, we used the BrainMap database to investigate whole-brainco-activation patterns between cerebellar structures and regions of the cerebral cortex, as well as associations with behavioral tasks. Hierarchical clustering was performed to meta-analytically identify cerebellar structures with similar cortical co-activation, and independently, with similar correlations to specific behavioral tasks. Strong correspondences were observed in these separate but parallel analyses of meta-analytic connectivity and behavioral metadata. We recovered differential zones of cerebellar co-activation that are reflected across the literature. Furthermore, the behaviors and tasks associated with the different cerebellar zones provide insight into the specialized function of the cerebellum, relating to high-order cognition, emotion, perception, interoception, and action. Taken together, these task-basedmeta-analytic results implicate distinct zones of the cerebellum as critically involved in the monitoring and mediation of psychological responses to internal and external stimuli.
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Riedel
authors.affiliation: Imaging Research Center, University of California Davis, Sacramento, CA, USA.
authors.forename: Kimberly L
authors.initials: KL
authors.lastname: Ray
authors.affiliation: Department of Psychology, Florida International University, Miami, FL, USA.
authors.forename: Anthony S
authors.initials: AS
authors.lastname: Dick
authors.affiliation: Department of Psychology, Florida International University, Miami, FL, USA.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Sutherland
authors.affiliation: Department of Electrical and Computer Engineering, University of Houston, Houston, TX, USA.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Hernandez
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA.
authors.forename: P Mickle
authors.initials: PM
authors.lastname: Fox
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany; Institute for Clinical Neuroscience and Medical Psychology, Heinrich-Heine University, Dusseldorf, Germany.
authors.forename: Simon B
authors.initials: SB
authors.lastname: Eickhoff
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA; South Texas Veterans Health Care System, San Antonio, TX, USA; State Key Laboratory for Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Fox
authors.affiliation: Department of Physics, Florida International University, Miami, FL, USA. Electronic address: alaird@fiu.edu.
authors.forename: Angela R
authors.initials: AR
authors.lastname: Laird
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D002531:Cerebellum / Q000033:anatomy & histology / Q000502:physiology*; D054022:Cerebrum / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008606:Mental Processes / Q000502:physiology*; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*
keywords: BrainMap; Cerebellum; Co-activations; Functional connectivity; MACM; Meta-analysis; Meta-analytic connectivity modeling; Neuroinformatics