title: Changes in lower urinary tract symptoms and quality of life after salvage radiotherapy for biochemical recurrence of prostate cancer.
abstract: OBJECTIVE
  The aim of this study was to evaluate chronologic changes in lower urinary tract symptoms (LUTS), health-related (HR) quality of life (QOL), and disease-specific QOL during the first 12 months after salvage radiotherapy (SRT) for biochemical recurrence of prostate cancer in patients who underwent radical prostatectomy.
  
  
  METHODS
  In 81 patients who received SRT (70 Gy/35fr/7 weeks), International Prostate Symptom Score (IPSS), 36-Item Short Form scores, and UCLA-Prostate Cancer Index (UCLA-PCI) were recorded before, during, and immediately after SRT, and 1-12 months after the completion of SRT.
  
  
  RESULTS
  The total IPSS and storage symptom-related sum were significantly increased following initiation of SRT, and returned to the baseline 6 months after SRT. For three of eight domains of HRQOL, and the physical component summary score showed transient deterioration in the period between completion of SRT and 1 month following SRT. The UCLA-PCI for urinary function/bother and bowel function/bother was affected until 1-6 months after SRT.
  
  
  CONCLUSIONS
  This is the first report to concurrently evaluate detailed chronologic changes in LUTS and QOL in patients who received SRT. Knowledge of changes in LUTS and QOL outcomes associated with SRT may influence treatment recommendations and enable patients to make better-informed decisions.
authors.affiliation: Department of Urology, Nara Medical University, Japan.
authors.forename: Makito
authors.initials: M
authors.lastname: Miyake
authors.affiliation: Department of Urology, Nara Medical University, Japan. Electronic address: sendo@naramed-u.ac.jp.
authors.forename: Nobumichi
authors.initials: N
authors.lastname: Tanaka
authors.affiliation: Department of Radiation Oncology, Nara Medical University, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Asakawa
authors.affiliation: Department of Urology, Nara Medical University, Japan; Department of Pathology, Nara Medical University, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tatsumi
authors.affiliation: Department of Urology, Nara Medical University, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakai
authors.affiliation: Department of Urology, Nara Medical University, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Anai
authors.affiliation: Department of Urology, Nara Medical University, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Torimoto
authors.affiliation: Department of Urology, Nara Medical University, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Aoki
authors.affiliation: Department of Urology, Nara Medical University, Japan.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yoneda
authors.affiliation: Department of Radiation Oncology, Nara Medical University, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hasegawa
authors.affiliation: Department of Pathology, Nara Medical University, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Konishi
authors.affiliation: Department of Urology, Nara Medical University, Japan.
authors.forename: Kiyohide
authors.initials: K
authors.lastname: Fujimoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000532:radiotherapy* / Q000601:surgery; D011788:Quality of Life; D016879:Salvage Therapy
keywords: Disease-specific quality of life; Health-related quality of life; International Prostate Symptom Score; Prostate cancer; SF-36; Salvage radiotherapy