title: Therapeutic strategies for synchronous and multiple liver metastases from colorectal cancer.
abstract: Metastasis in the liver is one of the most critical factors in the prognosis of patients with colorectal cancer. The incidence of synchronous liver metastasis has been found to be approximately 20-25%, but the optimal timing of surgical resection remains controversial. Neoadjuvant chemotherapy has also been found to be beneficial not only for initially unresectable but also resectable synchronous metastases and traditional surgical strategies of hepatic resection with past chemotherapeutic regimens have been used less and less over the past several years. This review will discuss treatments in association with the recently developed chemotherapeutic regimens.
authors.affiliation: Surgical Oncology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Osada
authors.affiliation: Surgical Oncology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Imai
authors.affiliation: Surgical Oncology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sasaki
authors.affiliation: Surgical Oncology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tanaka
authors.affiliation: Surgical Oncology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Matsuhashi
authors.affiliation: Surgical Oncology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Okumura
authors.affiliation: Surgical Oncology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Michitaka
authors.initials: M
authors.lastname: Nagase
authors.affiliation: Surgical Oncology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nonaka
authors.affiliation: Surgical Oncology, Gifu University School of Medicine, Gifu, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshida
keywords: chemotherapy; colorectal cancer; epithelial-to-mesenchymal transition.; surgical indication; synchronous and multiple liver metastasis