title: Association between apolipoprotein E gene polymorphism and depression.
abstract: We performed an updated meta-analysis to obtain a more precise estimation of the relationship between apolipoprotein E (ApoE) gene polymorphism and susceptibility to depression, as previous reports have been inconsistent. Twenty studies with 2286 depression patients and 3845 controls were included. Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association between ApoE gene polymorphism and depression using a random effects model. Results showed a significant association between ApoE gene polymorphism and susceptibility to depression in the overall population (ε2/ε3 genotype versus ε3/ε3: OR 0.76, 95% CI 0.59-0.99). Subgroup analyses indicated an association in the Caucasian population (ε2 allele versus ε3: OR 0.75, 95% CI 0.58-0.97) as well as in late-life depression (LLD) patients (ε3/ε4 genotype versus ε3/ε3: OR 1.34, 95% CI 1.07-1.68, and ε4 allele versus ε3: OR 1.30, 95% CI 1.06-1.59). We concluded that the ε2/ε3 genotype likely provided a protective effect against depression in the overall population and the ε2 allele acted as a protective factor for depression in the Caucasian population while the ε4 allele and ε3/ε4 genotype were associated with an increased risk of depression in the LLD subjects.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Feng
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Lu
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Hu
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
authors.forename: Feng-Feng
authors.initials: FF
authors.lastname: Gong
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Qian
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
authors.forename: Hui-Yun
authors.initials: HY
authors.lastname: Yang
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
authors.forename: Yi-Le
authors.initials: YL
authors.lastname: Wu
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Zhao
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address: pbi_ahmu_edu@126.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Bi
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; Centre for Evidence-Based Practice, Anhui Medical University, Hefei, Anhui, China. Electronic address: yhsun_ahmu_edu@yeah.net.
authors.forename: Ye-Huan
authors.initials: YH
authors.lastname: Sun
mesh_terms: D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D003863:Depression / Q000235:genetics* / Q000523:psychology*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E
keywords: ApoE; Apolipoprotein E; Depression; Meta-analysis; Polymorphism