title: Low risk of coronary artery disease in patients with acromegaly.
abstract: The aims of this study are to determine the prevalence of coronary atherosclerosis in acromegalic patients and to investigate the relationship between the coronary artery calcium score (CS) and acromegaly status and clinical parameters [Framingham risk score (FRS)]. Fifty-six acromegalic patients and paired non-acromegalic volunteers were stratified according to the FRS into low-, intermediate-, and high-risk groups. CS was assessed using multidetector computed tomography. The patients were considered to have controlled or active acromegaly at the time they were submitted to evaluation. Sixty-six percent of acromegalic patients exhibited arterial hypertension, 36 % had diabetes mellitus, and 34 % had hypercholesterolemia. The median FRS and the median risk for cardiovascular event within the next 10 years were similar in the acromegalics and the controls. The median total CS and CS >75th percentile didn't differ significantly between these groups. In patients with controlled acromegaly, a low, intermediate, or high FRS risk was observed in 86, 14, and 0 %, respectively. In patients with active disease, a low, intermediate, or high FRS risk was verified in 94, 3, and 3 %, respectively, and differences between the controlled and active groups were not significant. Seventy-two percent of the patients had total CS = 0, and there were no differences between the controlled and active groups. The risk of coronary artery disease in acromegalic patients, determined according to FRS and CS, is low despite the high prevalence of metabolic abnormalities.
authors.affiliation: Neuroendocrinology Research Center/Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco, 255, 9th floor, Ilha do Fundão, Rio de Janeiro, 21941-913, Brazil. cintiasilva.marques@bol.com.br.
authors.forename: Cintia Marques
authors.initials: CM
authors.lastname: Dos Santos Silva
authors.affiliation: Endocrinology Section, Medical School and Hospital Universitário Antônio Pedro - Universidade Federal Fluminense, Niterói, Brazil.
authors.forename: G A B
authors.initials: GA
authors.lastname: Lima
authors.affiliation: Cardiology Section, Medical School and Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: I C M
authors.initials: IC
authors.lastname: Volschan
authors.affiliation: Clínica de Diagnóstico por Imagem/Multi-Imagem, Rio de Janeiro, Brazil.
authors.forename: I
authors.initials: I
authors.lastname: Gottlieb
authors.affiliation: Neuroendocrinology Research Center/Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco, 255, 9th floor, Ilha do Fundão, Rio de Janeiro, 21941-913, Brazil.|Endocrinology Section, Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Kasuki
authors.affiliation: Neuroendocrinology Research Center/Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco, 255, 9th floor, Ilha do Fundão, Rio de Janeiro, 21941-913, Brazil.|Endocrinology Section, Hospital Federal da Lagoa, Rio de Janeiro, Brazil.
authors.forename: L Vieira
authors.initials: LV
authors.lastname: Neto
authors.affiliation: Neuroendocrinology Research Center/Endocrinology Section, Medical School and Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco, 255, 9th floor, Ilha do Fundão, Rio de Janeiro, 21941-913, Brazil. mgadelha@hucff.ufrj.br.
authors.forename: M R
authors.initials: MR
authors.lastname: Gadelha
mesh_terms: D000172:Acromegaly / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018570:Risk Assessment; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D013006:Growth Hormone
keywords: Acromegaly; Cardiac disease; Coronary artery calcium score; Framingham risk score