title: Circulating lymphocyte and T memory subsets in glucocorticosteroid versus IVIG treated patients with CIDP.
abstract: The present study compared lymphocyte and T memory subsets in currently untreated patients with chronic inflammatory demyelinating polyneuropathy (CIDP) to glucocorticosteroid (GS) and intravenous immunoglobulin (IVIG) treated patients. Peripheral blood from 48 CIDP patients (21 untreated who were either treatment naïve or without treatment during the last 3 months, 17 IVIG and 10 GS treatment) and from 12 age-matched controls was evaluated using flow cytometric analysis. Our data demonstrate that long-term GS treatment is associated with reduced frequencies of total CD4+ T cells, CD4+ memory subsets and NK cells while long-term IVIG treatment is associated with alterations of the CD8+ memory compartment. Reduction of CD4+ naïve T cell counts may explain the observation that GS treatment induces prolonged clinical remission compared to IVIG treatment.
authors.affiliation: Department of Neurology, Charité Universitaetsmedizin, Charitéplatz 1, Berlin, Germany. Electronic address: juliane.klehmet@charite.de.
authors.forename: Juliane
authors.initials: J
authors.lastname: Klehmet
authors.affiliation: Department of Neurology, Charité Universitaetsmedizin, Charitéplatz 1, Berlin, Germany. Electronic address: mx.staudt@gmail.com.
authors.forename: Max
authors.initials: M
authors.lastname: Staudt
authors.affiliation: Department of Neurology, Charité Universitaetsmedizin, Charitéplatz 1, Berlin, Germany. Electronic address: lena.ulm@charite.de.
authors.forename: Lena
authors.initials: L
authors.lastname: Ulm
authors.affiliation: Department of Immunology, Labor Berlin Charité Vivantes, Sylter Strasse 2, Berlin, Germany. Electronic address: nadine.unterwalder@laborberlin.com.
authors.forename: Nadine
authors.initials: N
authors.lastname: Unterwalder
authors.affiliation: Department of Neurology, Charité Universitaetsmedizin, Charitéplatz 1, Berlin, Germany. Electronic address: andreas.meisel@charite.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Meisel
authors.affiliation: Department of Medical Immunology, Charité Universitaetsmedizin, Berlin, Germany; Department of Immunology, Labor Berlin Charité Vivantes, Sylter Strasse 2, Berlin, Germany. Electronic address: christian.meisel@laborberlin.com.
authors.forename: Christian
authors.initials: C
authors.lastname: Meisel
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use*; D007156:Immunologic Memory / Q000187:drug effects*; D016130:Immunophenotyping; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000097:blood / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy; D011239:Prednisolone / Q000494:pharmacology / Q000627:therapeutic use*; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D011239:Prednisolone; D008775:Methylprednisolone
keywords: CIDP; Glucocorticosteroids; IVIG; NK cells; T memory subsets