title: [Juvenile onset respiratory papillomatosis: risk factors for severity].
abstract: OBJECTIVE
  This study was designed to explore the risk factors associated with severity of juvenile onset recurrent respiratory papillomatosis.
  
  
  METHODS
  A retrospective study was conducted to study determinants of severe forms of juvenile recurrent onset respiratory papillomatosis. The patients were separated into different groups based on the onset age, the first recurrence of age, the first recurrence of period, gender and incision of tracheal respectively. The relationship among the lesion severity score,the involvement of the subregion, operation period and the next operation period were also explored.
  
  
  RESULTS
  It was observed that some children who recurred before 4 years old required more surgery, shorter operation period(the average, longest or shortest operation period) than those elder children, the differences were statistically (P=0. 029, 0. 003, 0. 010, 0. 039, respectively). The severity score of lesion was correlated positively with the involvement of the subregion and negatively with operation period (r=0. 914, -0. 451, respectively). Some children who diagnosed before 4 years old had to endure more severity score and shorter operation period than those older children, the differences were statistically (P= 0. 036, 0. 000, respectively). 8 cases accepted incision of tracheal, they accepted more surgery too. But the differences in the onset age, the first recurrence of age, and the operation period were not statistically.
  
  
  CONCLUSIONS
  The results showed that the clinical course of juvenile onset recurrent respiratory papillomatosis was closely related to the first recurrence age and period, while the severity of disease was associated to the onset age and the involvement of the subregion.
authors.forename: Chuqin
authors.initials: C
authors.lastname: Zhang
authors.forename: Bobei
authors.initials: B
authors.lastname: Chen
authors.forename: Benyu
authors.initials: B
authors.lastname: Nan
authors.forename: Yingying
authors.initials: Y
authors.lastname: Chen
authors.forename: Jinjian
authors.initials: J
authors.lastname: Gao
authors.forename: Saiyu
authors.initials: S
authors.lastname: Huang
authors.forename: Haijie
authors.initials: H
authors.lastname: Xiang
authors.forename: Xiao
authors.initials: X
authors.lastname: Yu
authors.forename: Xuejun
authors.initials: X
authors.lastname: Liu
authors.forename: Baozhen
authors.initials: B
authors.lastname: Luo
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D006801:Humans; D010212:Papilloma; D030361:Papillomavirus Infections / Q000145:classification / Q000453:epidemiology* / Q000601:surgery; D012141:Respiratory Tract Infections / Q000145:classification / Q000453:epidemiology* / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D014132:Trachea