title: [Cytomegalovirus: congenital infection and clinical presentation in infants with respiratory distress syndrome].
abstract: BACKGROUND
  Respiratory distress syndrome (RDS) is a multifactorial and common disease that varies from 15 to 50 % in the newborn, causing 50 % of mortality. The RDS may be associated with bacterial and viral infections, and one of the most common viral agents is the cytomegalovirus (CMV). In the neonatal period the virus incidence goes from 0.4 to 2.5 % with a seroprevalence of 50 to 75 %; the incidence of infection in newborn with RDS is unknown. The objective was to determine the frequency of CMV infection in neonates with RDS and identify the risk factors associated with infection.
  
  
  METHODS
  The CMV-DNA was identified in plasma by quantitative PCR; maternal and neonatal variables that defined the clinical findings were analyzed by logistic regression.The CMV-DNA was identified in plasma by quantitative PCR; maternal and neonatal variables that defined the clinical findings were analyzed by logistic regression.
  
  
  RESULTS
  The frequency of CMV infection in 197 infants with RDS was 8.6 % (95 % CI, 4.7-12.5). The significant variables in newborn were: neutropenia (p = 0.012), thrombocytopenia (p = 0.021), mottled skin (p = 0.03), and the maternal significant variable was cervicovaginitis (p = 0.05).
  
  
  CONCLUSIONS
  We reported for the first time the highest frecuency of CMV infection in newborns with RDS and the association of various risk factors with CMV infection.
authors.affiliation: Unidad de Cuidados Intensivos Neonatales, Hospital de Gineco-Pediatría y Medicina Familiar 31, Instituto Mexicano del Seguro Social (IMSS), Mexicali, Baja California.
authors.forename: Angélica
authors.initials: A
authors.lastname: Martínez-Contreras
authors.forename: Rosalía
authors.initials: R
authors.lastname: Lira
authors.forename: Carmen
authors.initials: C
authors.lastname: Soria-Rodríguez
authors.forename: Sawako
authors.initials: S
authors.lastname: Hori-Oshima
authors.forename: Angélica
authors.initials: A
authors.lastname: Maldonado-Rodríguez
authors.forename: Othón
authors.initials: O
authors.lastname: Rojas-Montes
authors.forename: Rafael
authors.initials: R
authors.lastname: Ayala-Figueroa
authors.forename: Julia
authors.initials: J
authors.lastname: Estrada-Guzmán
authors.forename: Ma Teresa
authors.initials: MT
authors.lastname: Álvarez-Muñoz
mesh_terms: D003430:Cross-Sectional Studies; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D008800:Mexico; D015995:Prevalence; D012127:Respiratory Distress Syndrome, Newborn / Q000821:virology*; D012307:Risk Factors
keywords: Cytomegalovirus; Newborn infant; Newborn respiratory distress syndrome; Polymerase chain reaction