title: [Age-related changes in behavior, in monoamines and their metabolites content, and in density of D1 and D2 dopamine receptors in the brain structures of WAG/Rij rats with depression-like pathology].
abstract: Behavior in the light-dark choice, open field, sucrose consumption/preference and forced swimming tests, monoamines and their metabolites content in 5 brain structures (prefrontal cortex, nucleus accumbens, striatum, hypothalamus, hippocampus), and density of D1- and D2-like dopamine receptors in the prefrontal cortex, nucleus accumbens and ventral tegmental area were studied in WAG/Rij rats at age of 36 days, 3 and 6 months. It has been found that with age, as far as spike-wave discharges aggravate, behavioral symptoms of depression (enhanced immobility in the forced swimming test, reduced sucrose consumption/preference) as well as a hypo-function of the mesolimbic dopaminergic brain system increase in WAG/Rij rats. At age of 36 days, when phenotypic expression of absence epilepsy in WAG/Rij rats is absent, neurochemical alterations in the brain suggesting a hypo-function of the mesolimbic dopaminergic system (deficit of dopamine in the nucleus accumbens), as well as symptoms of depression-like behavior, are not detected. In WAG/Rij rats, as well as in control rats, density of D1-like dopamine receptors in the nucleus accumbens decreased with age. A tendency to a lower density of D1-like dopamine receptors was found in WAG/Rij rats compared with controls at age of 3 months. In contrast with control rats, in WAG/Rij rats, density of D2-like dopamine receptors in the nucleus accumbens increased with age. Higher density of D2-like dopamine receptors was observed in WAG/Rij rats compared with controls only at age of 6 months when a hypo-function of the mesolimbic dopaminergic bran system was extremely pronounced indicating that this increase is a compensatory response to a deficit of dopamine.
authors.forename: K Yu
authors.initials: KY
authors.lastname: Sarkisova
authors.forename: M A
authors.initials: MA
authors.lastname: Kulikov
authors.forename: V S
authors.initials: VS
authors.lastname: Kudrin
authors.forename: I S
authors.initials: IS
authors.lastname: Midzyanovskaya
authors.forename: L M
authors.initials: LM
authors.lastname: Birioukova
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001522:Behavior, Animal; D015306:Biogenic Monoamines / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism / Q000503:physiopathology; D003863:Depression / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D015870:Gene Expression; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D007031:Hypothalamus / Q000378:metabolism / Q000503:physiopathology; D008027:Light; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D017447:Receptors, Dopamine D1 / Q000235:genetics / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000235:genetics / Q000378:metabolism*; D013550:Swimming
chemical_list: D015306:Biogenic Monoamines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2