title: Diagnostic accuracy of a novel lateral-flow device in invasive aspergillosis: a meta-analysis.
abstract: A novel lateral-flow device (LFD) has been invented for use as a diagnostic tool for invasive aspergillosis (IA). We conducted a meta-analysis to assess the diagnostic accuracy of the device. Published studies that used the European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria and provided sufficient data were included. Two reviewers independently collected the data from each study and assessed the risk bias using the Quality Assessment of Diagnostic Accuracy Studies-2. The pooled sensitivity, specificity and diagnostic odds ratio (DOR) were computed and reported with a 95  % confidence interval (CI). Seven studies published between 2008 and March 2015 were included. The pooled sensitivity, specificity and DOR for the proven/probable versus no IA cases were 0.86 (95  % CI, 0.76-0.93), 0.93 (95  % CI, 0.89-0.96) and 65.94 (95  % CI, 27.21-159.81) in the LFD test using bronchoalveolar lavage (BAL) fluid, and 0.68 (95  % CI, 0.52-0.81), 0.87 (95  % CI, 0.80-0.92) and 11.90 (95  % CI, 3.54-39.96) in the LFD test using serum. We concluded that the Aspergillus LFD had a good diagnostic value in immunocompromised patients at risk of IA. The BAL LFD might have a better performance than the serum LFD test.
authors.affiliation: Respiratory Department, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, Zhejiang, PR China.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Pan
authors.affiliation: Respiratory Department, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, Zhejiang, PR China.
authors.forename: Mengjiao
authors.initials: M
authors.lastname: Fu
authors.affiliation: Cancer Institute, The Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, Zhejiang, PR China.
authors.forename: Jiaojiao
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Respiratory Department, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, Zhejiang, PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Respiratory Department, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, Zhejiang, PR China.
authors.forename: Yiqi
authors.initials: Y
authors.lastname: Fu
authors.affiliation: Respiratory Department, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, Zhejiang, PR China.
authors.forename: Jianying
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D000946:Antigens, Fungal / Q000097:blood*; D001228:Aspergillosis / Q000175:diagnosis* / Q000276:immunology*; D001230:Aspergillus / Q000276:immunology; D001992:Bronchoalveolar Lavage Fluid; D003955:Diagnostic Tests, Routine / Q000379:methods*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011785:Quality Assurance, Health Care; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D000911:Antibodies, Monoclonal; D000946:Antigens, Fungal