title: Admission glucose and risk of early death in non-diabetic patients with ST-segment elevation myocardial infarction: a meta-analysis.
abstract: BACKGROUND
  Impaired admission glucose (AG) is considered to significantly increase risk on both early and late death of the patients with ST-segment elevation myocardial infarction (STEMI), especially for non-diabetic patients; however, some reports contradict the relationship. We therefore conducted a meta-analysis to clarify this issue.
  
  
  METHODS
  PubMed, EMBASE, Web of Science, and Cochrane Library databases were systematically searched to identify all related prospective cohort studies. The relative risks (RR) with their 95% confidence interval (CI) were pooled quantitatively.
  
  
  RESULTS
  The pooled RR of early outcome events indicated patients with glucose concentrations ≥6.1-11.1 mmol/L had a 4.38-fold (95% CI, 3.23-5.94) higher early mortality. The pooled RR of late outcome events indicated that the patients with glucose concentrations ≥7.8-11.1 mmol/L had a 1.65-fold (95% CI, 1.33-2.04) higher late mortality based on in-hospital or 30-day survivors.
  
  
  CONCLUSIONS
  High AG may be a helpful prognostic marker of significantly increased risk on early death in non-diabetic patients with STEMI, and has an explicit but prognostic adverse impact on long-term mortality but not early mortality in these patients.
authors.affiliation: Department of Emergency, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China (mainland).
authors.forename: Cheng-jin
authors.initials: CJ
authors.lastname: Zhao
authors.affiliation: Department of Cardiology, Southern Medical University, The People's Hospital of Zhengzhou, Zhengzhou, Henan, China (mainland).
authors.forename: Zhen-xuan
authors.initials: ZX
authors.lastname: Hao
authors.affiliation: School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China (mainland).
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Southern Medical University, The People's Hospital of Zhengzhou, Zhengzhou, Henan, China (mainland).
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D004562:Electrocardiography; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000401:mortality / Q000628:therapy; D010343:Patient Admission; D011379:Prognosis; D011446:Prospective Studies; D012306:Risk; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D001786:Blood Glucose