title: [Two cases of conjunctival intraepithelial neoplasia in immunosuppressed patients].
abstract: Background: Conjunctival intraepithelial neoplasia (CIN) is a precursor lesion of conjunctival squamous cell carcinoma (SCC). CIN recurs frequently but progresses less aggressively than SCC. We report 2 cases of recurrent CIN in immunosuppressed patients.
  
  
  METHODS
  A 60-year-old woman had been taking oral immunosuppressive drugs for 30 years for systemic lupus erythematosus. In 2005, both conjunctival tumor and high serum SCC levels were noted. Biopsy revealed right eye CIN and left eye SCC, and extended resection was performed. In 2008, right eye CIN recurred accompanied by high serum SCC levels and another extended resection was performed. The patient was free from recurrence for 1 year until her death.
  
  
  METHODS
  A 43-year-old woman who had been taking oral immunosuppressive drugs for 3 years for nephrotic syndrome. She had twice undergone right corneal transplantation for keratoconus. In 2011, right conjunctival tumor and high serum SCC levels were noted. Biopsy revealed right eye CIN, for which an extended resection was performed. At present she remains free from recurrence.
  
  
  CONCLUSIONS
  CIN can recur in immunosuppressed patients. We suggest that serum SCC levels be monitored to help detect recurrence.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Asada
authors.forename: Kaori
authors.initials: K
authors.lastname: Ohtomo
authors.forename: Toshinari
authors.initials: T
authors.lastname: Funaki
authors.forename: Satoru
authors.initials: S
authors.lastname: Nakatani
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Ebihara
authors.forename: Akira
authors.initials: A
authors.lastname: Murakami
mesh_terms: D000328:Adult; D003230:Conjunctival Neoplasms / Q000150:complications / Q000276:immunology* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000150:complications / Q000276:immunology* / Q000473:pathology / Q000601:surgery*; D009404:Nephrotic Syndrome / Q000188:drug therapy; D012008:Recurrence
chemical_list: D007166:Immunosuppressive Agents