title: Association of AT1R polymorphism with hypertension risk: An update meta-analysis based on 28,952 subjects.
abstract: BACKGROUND
  Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension. However, the results remain controversial. In the present study, we performed a meta-analysis to systematically summarize the association between AT1R genetic polymorphisms and the risk for hypertension.
  
  
  METHODS
  We searched the literature in PubMed, EMBASE, ISI Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases (CNKI) to find case-control studies on the associations of AT1R genetic polymorphisms with the risk for hypertension. The meta-analysis was performed by using RevMan 5.0 software. The association of hypertension risk with AT1R genetic polymorphism was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs).
  
  
  RESULTS
  Fifty-six studies involving 28,952 subjects were included in the present meta-analysis. Our results suggest that the polymorphism (A1166C) of AT1R gene is associated with a statistically increased hypertension risk, not only in Asian populations but also in Caucasian populations. We did not find any association in African populations.
  
  
  CONCLUSIONS
  This meta-analysis suggests that A1166C polymorphism in the AT1R gene is associated with the risk of hypertension in Asian and Caucasian populations.
authors.affiliation: Emergency Department, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Dong-Xing
authors.initials: DX
authors.lastname: Liu
authors.affiliation: Health Division, The People's Hospital of HuaiYin, Jinan, China.
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Zhang
authors.affiliation: Emergency Department, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
authors.affiliation: Department of Cardiac Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Cardiac Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, China zhaoqngo@126.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*; D012307:Risk Factors
chemical_list: C544065:AGTR1 protein, human; D044140:Receptor, Angiotensin, Type 1
keywords: Genetic polymorphism; angiotensin II AT1 receptor; hypertension; meta-analysis