title: Minimal invasive surgical procedure of inducing myocardial infarction in mice.
abstract: Myocardial infarction still remains the main cause of death in western countries, despite considerable progress in the stent development area in the last decades. For clarification of the underlying mechanisms and the development of new therapeutic strategies, the availability of valid animal models are mandatory. Since we need new insights into pathomechanisms of cardiovascular diseases under in vivo conditions to combat myocardial infarction, the validity of the animal model is a crucial aspect. However, protection of animals are highly relevant in this context. Therefore, we establish a minimally invasive and simple model of myocardial infarction in mice, which assures a high reproducibility and survival rate of animals. Thus, this models fulfils the requirements of the 3R principle (Replacement, Refinement and Reduction) for animal experiments and assure the scientific information needed for further developing of therapeutical strategies for cardiovascular diseases.
authors.affiliation: Institute for Molecular Cardiovascular Research, RWTH Aachen University, Germany.
authors.forename: Adelina
authors.initials: A
authors.lastname: Curaj
authors.affiliation: Institute for Molecular Cardiovascular Research, RWTH Aachen University, Germany.
authors.forename: Sakine
authors.initials: S
authors.lastname: Simsekyilmaz
authors.affiliation: Institute for Molecular Cardiovascular Research, RWTH Aachen University, Germany.
authors.forename: Mareike
authors.initials: M
authors.lastname: Staudt
authors.affiliation: Institute for Molecular Cardiovascular Research, RWTH Aachen University, Germany; eliehn@ukaachen.de.
authors.forename: Elisa
authors.initials: E
authors.lastname: Liehn
mesh_terms: D000818:Animals; D006348:Cardiac Surgical Procedures / Q000379:methods / Q000662:veterinary*; D004195:Disease Models, Animal; D008026:Ligation / Q000662:veterinary; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D019060:Minimally Invasive Surgical Procedures / Q000379:methods / Q000662:veterinary*; D009203:Myocardial Infarction / Q000209:etiology*; D015203:Reproducibility of Results; D015607:Stents