title: Metachronous multicentric giant cell tumour in a young woman.
abstract: Multicentric giant cell tumours (GCTs) are very rare and account for less than 1% of all GCTs of bone. We report a case of a young woman with metachronous multicentric GCTs with 5 documented lesions in the same lower limb. The initial lesion started during the first trimester of pregnancy around her right pelvis, which rapidly progressed as a painful swelling with gradually restricted mobility of her right hip joint. The radiological appearance of this tumour was that of a GCT and biopsy confirmed the diagnosis. The role of positron emission tomography (PET) has been highlighted to detect occult lesions. A possible hormonal correlation for these tumours has been discussed. The patient was managed successfully by an aggressive surgical approach for knee and talar lesions, whereas repeated embolisation and denosumab injections were given to treat her pelvic lesion.
authors.affiliation: Department of Orthopaedics & Joint Replacement Surgery, Indraprastha Apollo Hospitals, New Delhi, India.
authors.forename: Raju
authors.initials: R
authors.lastname: Vaishya
authors.affiliation: Department of Orthopaedics & Joint Replacement Surgery, Indraprastha Apollo Hospitals, New Delhi, India.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Agarwal
authors.affiliation: Department of Orthopaedics & Joint Replacement Surgery, Indraprastha Apollo Hospitals, New Delhi, India.
authors.forename: Vipul
authors.initials: V
authors.lastname: Vijay
authors.affiliation: Department of Orthopaedics, Sancheti Hospital, Pune, Maharashtra, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Vaish
mesh_terms: D000328:Adult; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D000069448:Denosumab / Q000008:administration & dosage*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D035002:Lower Extremity / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D049268:Positron-Emission Tomography; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D050071:Bone Density Conservation Agents; D000069448:Denosumab