title: Hemodynamics and vasoactive substance levels during renal congestion that occurs in the anhepatic phase of liver transplantation.
abstract: OBJECTIVE
  To explore hemodynamics and vasoactive substance levels during renal vein congestion that occurs in the anhepatic phase of liver transplantation.
  
  
  METHODS
  New Zealand rabbits received ligation of the hepatic pedicle, supra-hepatic vena cava and infra-hepatic vena cava [anhepatic phase group (APH); n = 8], the renal veins (RVL; n = 8), renal veins and hepatic pedicle [with the inferior vena cava left open) (RVHP; n = 8)], or a sham operation (SOP; n = 8). Hemodynamic parameters (systolic, diastolic, and mean arterial blood pressures) and the levels of serum bradykinin (BK) and angiotensin II (ANGII) were measured at baseline (0 min), and 10 min, 20 min, 30 min, and 45 min after the surgery. Correlation analyses were performed to evaluate the associations between hemodynamic parameters and levels of vasoactive substances.
  
  
  RESULTS
  All experimental groups (APH, RVL, and RVHP) showed significant decreases in hemodynamic parameters (systolic, diastolic, and mean arterial blood pressures) compared to baseline levels, as well as compared to the SOP controls (P < 0.05 for all). In contrast, BK levels were significantly increased compared to baseline in the APH, RVL, and RVHP groups at all time points measured (P < 0.05 for all), whereas no change was observed in the SOP controls. There were no significant differences among the experimental groups for any measure at any time point. Further analyses revealed that systolic, diastolic, and mean arterial blood pressures were all negatively correlated with BK levels, and positively correlated with ANGII levels in the APH, RVL, and RVHP groups (P < 0.05 for all).
  
  
  CONCLUSIONS
  In the anhepatic phase of orthotopic liver transplantation, renal vein congestion significantly impacts hemodynamic parameters, which correlate with serum BK and ANGII levels.
authors.affiliation: Zhong-Xin Li, Man-Cai Wang, Mo Chen, Rui Ni, Feng-Xian Wei, Gen-Nian Wang, Ling-Yi Zhang, Department of Hepatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors.forename: Zhong-Xin
authors.initials: ZX
authors.lastname: Li
authors.affiliation: Zhong-Xin Li, Man-Cai Wang, Mo Chen, Rui Ni, Feng-Xian Wei, Gen-Nian Wang, Ling-Yi Zhang, Department of Hepatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors.forename: Man-Cai
authors.initials: MC
authors.lastname: Wang
authors.affiliation: Zhong-Xin Li, Man-Cai Wang, Mo Chen, Rui Ni, Feng-Xian Wei, Gen-Nian Wang, Ling-Yi Zhang, Department of Hepatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors.forename: You-Cheng
authors.initials: YC
authors.lastname: Zhang
authors.affiliation: Zhong-Xin Li, Man-Cai Wang, Mo Chen, Rui Ni, Feng-Xian Wei, Gen-Nian Wang, Ling-Yi Zhang, Department of Hepatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Mao
authors.affiliation: Zhong-Xin Li, Man-Cai Wang, Mo Chen, Rui Ni, Feng-Xian Wei, Gen-Nian Wang, Ling-Yi Zhang, Department of Hepatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors.forename: Mo
authors.initials: M
authors.lastname: Chen
authors.affiliation: Zhong-Xin Li, Man-Cai Wang, Mo Chen, Rui Ni, Feng-Xian Wei, Gen-Nian Wang, Ling-Yi Zhang, Department of Hepatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Ni
authors.affiliation: Zhong-Xin Li, Man-Cai Wang, Mo Chen, Rui Ni, Feng-Xian Wei, Gen-Nian Wang, Ling-Yi Zhang, Department of Hepatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors.forename: Feng-Xian
authors.initials: FX
authors.lastname: Wei
authors.affiliation: Zhong-Xin Li, Man-Cai Wang, Mo Chen, Rui Ni, Feng-Xian Wei, Gen-Nian Wang, Ling-Yi Zhang, Department of Hepatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors.forename: Gen-Nian
authors.initials: GN
authors.lastname: Wang
authors.affiliation: Zhong-Xin Li, Man-Cai Wang, Mo Chen, Rui Ni, Feng-Xian Wei, Gen-Nian Wang, Ling-Yi Zhang, Department of Hepatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China.
authors.forename: Ling-Yi
authors.initials: LY
authors.lastname: Zhang
mesh_terms: D000804:Angiotensin II / Q000097:blood*; D000818:Animals; D001920:Bradykinin / Q000097:blood*; D006439:Hemodynamics; D008026:Ligation; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D011817:Rabbits; D012079:Renal Circulation; D012082:Renal Veins / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors
chemical_list: D000804:Angiotensin II; D001920:Bradykinin
keywords: Anhepatic phase; Hemodynamics; Orthotopic liver transplantation; Renal vein congestion; Vasoactive substances