title: Influence of Treatment with Extracts of Hypsyzigus marmoreus Mushroom on Body Composition during Obesity Development in KK-A(y) Mice.
abstract: Hypsyzigus marmoreus (HM), an edible mushroom, has several effects, including antitumor, antioxidant and anti-allergy properties. On the other hand, the possibly useful effect of HM in diabetic mice has not as yet been elucidated. In this study, we showed treatment with a water soluble extract from HM (EHM) to reduce fat deposits without affecting body weight loss in KK-A(y) mice. EHM treatment also abolished the expressions of pro-inflammatory adipokines, such as tumor necrosis factor α and monocyte chemoattractant protein 1, as compared with vehicle treatment. The expressions of uncoupling protein 3 and peroxisome proliferator-activated receptor gamma coactivator 1α in the soleus muscles of EHM treatment groups were significantly elevated as compared to those in vehicle-treated muscle tissues. These results raise the possibility that EHM can regulate both obesity and insulin resistance.
authors.affiliation: Department of Endocrinology and Diabetes, Saitama Medical University Hospital.
authors.forename: Takujiro
authors.initials: T
authors.lastname: Iuchi
authors.forename: Toshio
authors.initials: T
authors.lastname: Hosaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shiroishi
authors.forename: Hiraku
authors.initials: H
authors.lastname: Ono
authors.forename: Kouichi
authors.initials: K
authors.lastname: Inukai
authors.forename: Takashi
authors.initials: T
authors.lastname: Sumita
authors.forename: Gouta
authors.initials: G
authors.lastname: Sakai
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Katayama
authors.forename: Takuya
authors.initials: T
authors.lastname: Awata
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D000363:Agaricales; D000818:Animals; D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use*; D001823:Body Composition / Q000187:drug effects*; D007249:Inflammation / Q000209:etiology / Q000378:metabolism; D007333:Insulin Resistance; D007473:Ion Channels / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000378:metabolism; D051379:Mice; D024101:Mitochondrial Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D000071247:Uncoupling Protein 3; D015431:Weight Loss / Q000187:drug effects
chemical_list: D054392:Adipokines; D001688:Biological Products; D007473:Ion Channels; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D047495:PPAR gamma; C000604393:Ucp3 protein, mouse; D000071247:Uncoupling Protein 3