title: Anti-tumor activities of active ingredients in Compound Kushen Injection.
abstract: Kushen (Radix Sophorae Flavescentis) has a long history of use for the treatment of tumors, inflammation and other diseases in traditional Chinese medicine. Compound Kushen Injection (CKI) is a mixture of natural compounds extracted from Kushen and Baituling (Rhizoma Smilacis Glabrae). The main principles of CKI are matrine (MT) and oxymatrine (OMT) that exhibit a variety of pharmacological activities, including anti-inflammatory, anti-allergic, anti-viral, anti-fibrotic and cardiovascular protective effects. Recent evidence shows that these compounds also produce anti-cancer actions, such as inhibiting cancer cell proliferation, inducing cell cycle arrest, accelerating apoptosis, restraining angiogenesis, inducing cell differentiation, inhibiting cancer metastasis and invasion, reversing multidrug resistance, and preventing or reducing chemotherapy- and/or radiotherapy-induced toxicity when combined with chemotherapeutic drugs. In this review, we summarize recent progress in studying the anti-cancer activities of MT, OMT and CKI and their potential molecular targets, which provide clues and references for further study.
authors.affiliation: 1] Beijing Zhendong Guangming Pharmaceutical Research Institute Co Ltd, Beijing 100120, China [2] Shanxi Zhendong Pharmaceutical Co Ltd, Changzhi 047100, China [3] Gastroenterology Department, the Second People's Hospital of Zhuhai, Zhuhai 519000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: 1] Beijing Zhendong Guangming Pharmaceutical Research Institute Co Ltd, Beijing 100120, China [2] Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Rong-li
authors.initials: RL
authors.lastname: You
authors.affiliation: Beijing Zhendong Guangming Pharmaceutical Research Institute Co Ltd, Beijing 100120, China.
authors.forename: Wen-jie
authors.initials: WJ
authors.lastname: Qin
authors.affiliation: Beijing Zhendong Guangming Pharmaceutical Research Institute Co Ltd, Beijing 100120, China.
authors.forename: Li-na
authors.initials: LN
authors.lastname: Hai
authors.affiliation: Beijing Zhendong Guangming Pharmaceutical Research Institute Co Ltd, Beijing 100120, China.
authors.forename: Ming-jing
authors.initials: MJ
authors.lastname: Fang
authors.affiliation: Department of Respiration, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China.
authors.forename: Guo-hua
authors.initials: GH
authors.lastname: Huang
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Rui-xia
authors.initials: RX
authors.lastname: Kang
authors.affiliation: Shanxi Zhendong Pharmaceutical Co Ltd, Changzhi 047100, China.
authors.forename: Ming-hua
authors.initials: MH
authors.lastname: Li
authors.affiliation: Shanxi Zhendong Pharmaceutical Co Ltd, Changzhi 047100, China.
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Qiao
authors.affiliation: 1] Shanxi Zhendong Pharmaceutical Co Ltd, Changzhi 047100, China [2] Department of Pharmacy, Chang Zhi Medical College, Changzhi 046000, China.
authors.forename: Jian-wei
authors.initials: JW
authors.lastname: Li
authors.affiliation: Shanxi Zhendong Pharmaceutical Co Ltd, Changzhi 047100, China.
authors.forename: An-ping
authors.initials: AP
authors.lastname: Li
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000032:analysis; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000032:analysis; D006801:Humans; D007267:Injections; D008516:Medicine, Chinese Traditional / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011807:Quinolizines / Q000008:administration & dosage; D016896:Treatment Outcome; D000093842:Matrines
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D011807:Quinolizines; C037573:oxymatrine; C494416:kushen; D000093842:Matrines