title: Mitochondrial uncoupling protein (UCP2) gene expression is regulated by miR-2909.
abstract: Reversible decoupling of glycolysis from aerobic-respiration has been widely recognized to be a crucial step in tailoring immune response by the human cells. In this context, the study reported here revealed for the first time that cooperativity between Apoptosis Antagonizing Transcription Factor (AATF) mRNA and miR-2909 within cellular AATF RNome ensures the regulation of mitochondrial uncoupling protein 2 (UCP2) expression in a cyclic fashion and this phenomenon is substantiated when the immune cells face high glucose threat.
authors.affiliation: Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India. Electronic address: dkaul_24@hotmail.com.
authors.forename: Deepak
authors.initials: D
authors.lastname: Kaul
authors.affiliation: Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.affiliation: Department of Experimental Medicine & Biotechnology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, India.
authors.forename: A
authors.initials: A
authors.lastname: Garg
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism*; D018946:Chemokine CCL5 / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics / Q000378:metabolism; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism*; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D061251:Primary Cell Culture; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D016329:Sp1 Transcription Factor / Q000235:genetics / Q000378:metabolism; D051996:Transcription Factor RelA / Q000235:genetics / Q000378:metabolism; D014162:Transfection; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D000071246:Uncoupling Protein 2
chemical_list: C402637:AATF protein, human; D051017:Apoptosis Regulatory Proteins; C483024:CCL5 protein, human; D018946:Chemokine CCL5; D020381:Interleukin-17; D007473:Ion Channels; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors; C000589020:MIRN2909 microRNA, human; D035683:MicroRNAs; D024101:Mitochondrial Proteins; C498143:RELA protein, human; D034741:RNA, Small Interfering; D012097:Repressor Proteins; D016329:Sp1 Transcription Factor; C108209:SP1 protein, human; D051996:Transcription Factor RelA; D016159:Tumor Suppressor Protein p53; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2; D005947:Glucose
keywords: AATF RNome; CCL5; IL-17; Regulation; UCP2