title: Hypomagnesaemia in kidney transplantation.
abstract: In the era of calcineurin inhibitors, hypomagnesaemia is a very common finding in kidney transplant recipients. Especially the first weeks after transplantation it is the rule rather than the exception. Hypomagnesaemia or low magnesium intake have been associated with a higher mortality or more cardiovascular events in the general population, but this association has never been explored in kidney transplant recipients, despite their increased cardiovascular risk. Kidney transplant recipients with pre- or post-transplant hypomagnesaemia seem to have an aberrant glucose metabolism and develop diabetes mellitus more frequently. Moreover, observations from alternate study populations, animal experiments or in vitro studies suggest a possible role of magnesium deficiency in graft dysfunction, bone metabolism and transplant immunology. Future observational and especially interventional studies should further define whether and to what extent we should make effort to correct this electrolyte disturbance in transplant recipients. Considering the mechanism of renal magnesium wasting, normalizing the serum magnesium concentration by oral supplementation alone might turn out to be cumbersome in kidney transplant recipients.
authors.affiliation: Renal Division, Ghent University Hospital, Ghent, Belgium. Electronic address: steven.vanlaecke@ugent.be.
authors.forename: Steven
authors.initials: S
authors.lastname: Van Laecke
authors.affiliation: Renal Division, Ghent University Hospital, Ghent, Belgium. Electronic address: wim.vanbiesen@ugent.be.
authors.forename: Wim
authors.initials: W
authors.lastname: Van Biesen
mesh_terms: D065095:Calcineurin Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D008274:Magnesium / Q000097:blood* / Q000378:metabolism; D008275:Magnesium Deficiency / Q000209:etiology / Q000503:physiopathology; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology / Q000503:physiopathology; D015499:Renal Tubular Transport, Inborn Errors / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D018570:Risk Assessment
chemical_list: D065095:Calcineurin Inhibitors; D008274:Magnesium