title: Multifunctional gold nanostar-based nanocomposite: Synthesis and application for noninvasive MR-SERS imaging-guided photothermal ablation.
abstract: We report here the design and facile synthesis of multifunctional gold nanostars based nanocomposites (MGSNs) through direct organosilica coating onto anisotropic gold nanostars followed by the conjugation of Gd chelates. The as-synthesized MGSNs possess strong NIR absorbance, SERS signal and enhanced T1-MR imaging capability with excellent dispersivity and uniform size, as well as great photothermal stability and Raman stability under photothermal conditions. Importantly, MGSNs present excellent performance in vivo after their intravenous injection for both MR and SERS imaging and the high efficiency for killing tumor cells through photothermal ablation with NIR irradiation. A combination of the high spatial resolution of MR and the exciting sub-cell-level sensitivity and resolution of SERS can provide comprehensive information about the tumor to achieve the optimized therapeutic outcome. Therefore, MGSNs are of great potential as a multifunctional nanoplatform for MR-SERS bimodal imaging-guided, focused photothermal tumor therapy.
authors.affiliation: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Yongping
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. Electronic address: ysli@ecust.edu.cn.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Jianzhuang
authors.initials: J
authors.lastname: Chen
authors.affiliation: State Key Lab of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Shaojia
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Xiaohang
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Radiology, Shanghai Cancer Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Liangping
authors.initials: L
authors.lastname: Zhou
authors.affiliation: State Key Lab of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Shi
authors.affiliation: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Dechao
authors.initials: D
authors.lastname: Niu
authors.affiliation: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
authors.forename: Jinlou
authors.initials: J
authors.lastname: Gu
authors.affiliation: Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China; Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China. Electronic address: jlshi@mail.sic.ac.cn.
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002614:Chelating Agents / Q000737:chemistry / Q000627:therapeutic use; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008807:Mice, Inbred BALB C; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D009942:Organometallic Compounds / Q000737:chemistry / Q000627:therapeutic use*; D017646:Organosilicon Compounds / Q000737:chemistry / Q000627:therapeutic use*; D010789:Phototherapy / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000627:therapeutic use; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D002614:Chelating Agents; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D017646:Organosilicon Compounds; D011092:Polyethylene Glycols; D006046:Gold; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
keywords: Gold; MRI; Nanocomposite; Photothermal therapy; SERS