title: Translational biomarkers of acetaminophen-induced acute liver injury.
abstract: Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial injury. The systems biology omics technologies (transcriptomics, proteomics and metabolomics) have been used to discover potential translational biomarkers of liver injury. The following review provides a summary of the systems biology discovery process, analytical validation of biomarkers and translation of omics biomarkers from the nonclinical to clinical setting in APAP-induced liver injury.
authors.affiliation: Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, USA, Richard.Beger@fda.hhs.gov.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Beger
authors.forename: Sudeepa
authors.initials: S
authors.lastname: Bhattacharyya
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Pritmohinder S
authors.initials: PS
authors.lastname: Gill
authors.forename: Laura K
authors.initials: LK
authors.lastname: Schnackenberg
authors.forename: Jinchun
authors.initials: J
authors.lastname: Sun
authors.forename: Laura P
authors.initials: LP
authors.lastname: James
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000208:ethnology* / Q000503:physiopathology; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000473:pathology; D057170:Translational Research, Biomedical / Q000379:methods
chemical_list: D018712:Analgesics, Non-Narcotic; D015415:Biomarkers; D000082:Acetaminophen; D005978:Glutathione