title: The birth and future health of DOHaD.
abstract: Professor David Barker, CBE, FRS, made an enormous contribution to biomedical research, which helped to change its direction and assisted translation to clinical medicine in the area of non-communicable disease (NCD). In this paper, I briefly note some of the studies, which led to his work, and describe how the underlying mechanisms came to be investigated by fetal physiologists. This is a unique aspect of the change in scientific emphasis, from a gene-centric and adult lifestyle view of NCD to a more holistic perspective, which placed emphasis on the importance of development that took place in the late 20th century. Early this century, the DOHaD Society was formed: I discuss some aspects of the formation of the Society and note the important role it is now playing in addressing the need to find early-life interventions to reduce NCD. This forms part of the unique legacy that David Barker has left to science and medicine.
authors.affiliation: Institute of Developmental Sciences and NIHR Nutrition Biomedical Research Centre,University of Southampton and University Hospital Southampton,Southampton,UK.
authors.forename: M
authors.initials: M
authors.lastname: Hanson
mesh_terms: D000328:Adult; D002658:Developmental Disabilities / Q000503:physiopathology*; D005247:Feeding Behavior; D015438:Health Behavior; D006801:Humans; D008019:Life Style
keywords: Barker; fetus; human; physiology