title: Expedited CO2 respiration in people with Miltenberger erythrocyte phenotype GP.Mur.
abstract: In Southeast Asia, Miltenberger antigen subtype III (Mi.III; GP.Mur) is considered one of the most important red blood cell antigens in the field of transfusion medicine. Mi.III functions to promote erythrocyte band 3 expression and band 3-related HCO3(-) transport, with implications in blood CO2 metabolism. Could Mi.III affect physiologic CO2 respiration in its carriers? Here, we conducted a human trial to study the impacts of Mi.III expression in respiration. We recruited 188 healthy, adult subjects for blood typing, band 3 measurements, and respiratory tests before and after exercise. The 3-minute step exercise test forced the demand for CO2 dissipation to rise. We found that immediately following exercise, Mi.III + subjects exhaled CO2 at greater rates than Miltenberger-negative subjects. Respiration rates were also higher for Mi.III + subjects immediately after exercise. Blood gas tests further revealed distinct blood CO2 responses post-exercise between Mi.III and non-Mi.III. In contrast, from measurements of heart rates, blood O2 saturation and lactate, Mi.III phenotype was found to be independent of one's aerobic and anaerobic capacities. Thus, Mi.III expression supported physiologic CO2 respiration. Conceivably, Mi.III + people may have advantages in performing physically enduring activities.
authors.affiliation: Transfusion Medicine Laboratory, Mackay Memorial Hospital, Tamsui, Taiwan.
authors.forename: Kate
authors.initials: K
authors.lastname: Hsu
authors.affiliation: Department of Laboratory Medicine, Mackay Memorial Hospital, Taitung, Taiwan.
authors.forename: Mei-Shin
authors.initials: MS
authors.lastname: Kuo
authors.affiliation: Transfusion Medicine Laboratory, Mackay Memorial Hospital, Tamsui, Taiwan.
authors.forename: Ching-Che
authors.initials: CC
authors.lastname: Yao
authors.affiliation: Transfusion Medicine Laboratory, Mackay Memorial Hospital, Tamsui, Taiwan.
authors.forename: Ting-Ying
authors.initials: TY
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, Mackay Memorial Hospital, Taitung, Taiwan.
authors.forename: Yi-Chun
authors.initials: YC
authors.lastname: Chen
authors.affiliation: Department of Laboratory Medicine, Mackay Memorial Hospital, Taitung, Taiwan.
authors.forename: Han-Chih
authors.initials: HC
authors.lastname: Cheng
authors.affiliation: Department of Physical Education, National Taitung University, Taitung, Taiwan.
authors.forename: Chia-Hao
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Department of Physical Education, National Taitung University, Taitung, Taiwan.
authors.forename: Tzung-Han
authors.initials: TH
authors.lastname: Yu
authors.affiliation: Transfusion Medicine Laboratory, Mackay Memorial Hospital, Tamsui, Taiwan.
authors.forename: Hui-Ju
authors.initials: HJ
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D002245:Carbon Dioxide / Q000097:blood / Q000378:metabolism*; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism*; D015444:Exercise; D005260:Female; D006021:Glycophorins / Q000378:metabolism*; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010641:Phenotype; D055815:Young Adult
chemical_list: D006021:Glycophorins; C068315:Miltenberger III-like molecule glycophorin variant; D002245:Carbon Dioxide; D019344:Lactic Acid; D010100:Oxygen