title: [Effects of selenium compounds on proliferation, migration and adhesion of HeLa cells].
abstract: OBJECTIVE
  To explore the effects of methylseleninic acid (MeSeA), selenomethionine (SeMet) and methylselenocysteine (MeSeCys) on proliferation, migration and adhesion of HeLa cells.
  
  
  METHODS
  HeLa cells were cultured and treated with MeSeA, SeMet and MeSeCys for 12 - 72 h respectively. MTT assay, healing assay and in vitro cell Matrigel adhesion assay were used to detect the proliferation, migration and adhesion of HeLa cells.
  
  
  RESULTS
  Compared to the control group, the proliferation of HeLa cells was remarkably inhibited by MeSeA (P <0. 01). The migration of HeLa cells in MeSeA group was inhibited by 34% (P < 0. 05) and 26% (P < 0. 05) in 4 h and 8 h, respectively. However, the migration of HeLa cells with inhibitions of 18% and 13% was in SeMet group in 4 h and 8 h. The inhibitions of HeLa cell migration in MeSeCys group was 28% (P < 0.05) and 5% in 4 h and 8 h, respectively. In addition, the adhesive function of HeLa cells in the MeSeA group, the SeMet group as well as the MeSeCys group were inhibited by 36% (P < 0. 01), 25% and 49% (P < 0. 01).
  
  
  CONCLUSIONS
  The proliferation and migration of HeLa cell were effectively inhibited by MeSeA, while the adhesive function of HeLa cell was remarkably inhibited by MeSeCys.
authors.forename: Licui
authors.initials: L
authors.lastname: Sun
authors.forename: Jiaxi
authors.initials: J
authors.lastname: Lu
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Han
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Yang
authors.forename: Hongkun
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhenwu
authors.initials: Z
authors.lastname: Huang
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects*; D006367:HeLa Cells / Q000187:drug effects*; D006801:Humans; D016566:Organoselenium Compounds / Q000494:pharmacology*; D012643:Selenium; D018036:Selenium Compounds / Q000494:pharmacology; D017279:Selenocysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D012645:Selenomethionine / Q000494:pharmacology*
chemical_list: D016588:Anticarcinogenic Agents; D016566:Organoselenium Compounds; D018036:Selenium Compounds; D017279:Selenocysteine; D012645:Selenomethionine; C008493:methylselenic acid; D012643:Selenium; C002979:selenomethylselenocysteine