title: Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders.
abstract: The choroid plexus (CP) is a highly vascularized organ located in the brain ventricles and contains a single epithelial cell layer forming the blood-cerebrospinal fluid barrier (BCSFB). This barrier is crucial for immune surveillance in health and is an underestimated gate for entry of immune cells during numerous inflammatory disorders. Several of these disorders are accompanied by disturbance of the BCSFB and increased leukocyte infiltration, which affects neuroinflammation. Understanding the mechanism of immune cell entry at the CP might lead to identification of new therapeutic targets. Here, we focus on current knowledge of leukocyte infiltration at the CP in inflammatory conditions and its therapeutic implications.
authors.affiliation: Inflammation Research Center, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
authors.forename: Delphine
authors.initials: D
authors.lastname: Demeestere
authors.affiliation: Inflammation Research Center, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
authors.forename: Claude
authors.initials: C
authors.lastname: Libert
authors.affiliation: Inflammation Research Center, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. Electronic address: Roosmarijn.Vandenbroucke@irc.VIB-UGent.be.
authors.forename: Roosmarijn E
authors.initials: RE
authors.lastname: Vandenbroucke
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002831:Choroid Plexus / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000276:immunology; D058990:Molecular Targeted Therapy; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000276:immunology; D015398:Signal Transduction; D013119:Spinal Cord Injuries / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000276:immunology; D057705:Transendothelial and Transepithelial Migration / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents