title: Acetazolamide may provoke cyclosporine toxicity-a case report.
abstract: We describe a 58-year-old female renal transplantant recipient with standard cyclosporine-based immunosuppression who developed a potentially toxic cyclosporine concentration of 265 ng/ml after having started acetazolamide for severe glaucoma. The mechanism explaining the interaction between acetazolamide and cyclosporine remains unknown, but the concomitant use of these agents is not uncommon. The follow-up of cyclosporine concentrations is necessary, and the reduction of the cyclosporine dose is likely to be needed when patients taking cyclosporine are started with acetazolamide.
authors.affiliation: Department of Clinical Pharmacology , University of Helsinki , Helsinki , Finland.
authors.forename: Päivi
authors.initials: P
authors.lastname: Ruokoniemi
authors.affiliation: Department of Internal Medicine , Turku University Hospital , Turku.
authors.forename: Risto
authors.initials: R
authors.lastname: Tertti
authors.affiliation: Department of Internal Medicine.
authors.forename: Pia
authors.initials: P
authors.lastname: Paalosmaa-Puusa
authors.affiliation: Department of Ophthalmology , Salo District Hospital , Salo.
authors.forename: Hannele
authors.initials: H
authors.lastname: Kareranta
authors.forename: Kari
authors.initials: K
authors.lastname: Laine
keywords: acetazolamide; cyclosporine; drug interactions; renal transplantation