title: Comparing the Effectiveness of Total Gastrectomy and Gastric Bypass on Glucose Metabolism in Diabetic Rats.
abstract: BACKGROUND
  Bariatric surgeries have been widely used in obesity associated type II diabetes. However, the mechanisms of surgical treatments for type II diabetes in non-obese patients remain controversial. Our study aims to compare the effectiveness of various bariatric surgeries in a non-obese diabetic rat model.
  
  
  METHODS
  Goto-Kakisaki (GK) rats were used to compare the outcome of total gastrectomy (TG), Roux-en-Y reconstruction after total gastrectomy (RYTG), and Roux-En-Y gastric bypass (RYGB). Body weight, food and water intake, and glucose level were monitored prior to and after surgery. Oral glucose tolerance tests (OGTT) were performed, and key metabolic hormones were measured at selected time points.
  
  
  RESULTS
  Despite a significant reduction in body weight in TG and RYTG groups, their glucose metabolic rate was not improved. RYGB rats, with only moderate reduction in food intake and body weight, had significantly improved glucose metabolism. Insulin and ghrelin were significantly reduced in TG and RYTG groups, but remained unchanged in RYGB group.
  
  
  CONCLUSIONS
  Our study demonstrated the effectiveness of RYGB surgery in treating type II diabetes in non-obese diabetic rats. These results suggest an important role of gastric system in regulating glucose homeostasis.
authors.affiliation: Department of General Surgery, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China. zdl1831@gmail.com.
authors.forename: Donglei
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Department of General Surgery, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China. jiangx12@163.com.
authors.forename: Xun
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of General Surgery, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China. jeanwe911@126.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Jian
authors.affiliation: Department of General Surgery, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China. lijunzheng998@163.com.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zheng
authors.affiliation: Department of General Surgery, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China. zhoudonglei1632@126.com.
authors.forename: Liesheng
authors.initials: L
authors.lastname: Lu
authors.affiliation: Department of General Surgery, Changhai Hospital of the Second Military Medical University, Shanghai, China. fredzhengzz@126.com.
authors.forename: Chengzhu
authors.initials: C
authors.lastname: Zheng
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D005743:Gastrectomy; D015390:Gastric Bypass; D054439:Ghrelin / Q000097:blood; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006706:Homeostasis; D007328:Insulin / Q000097:blood; D051381:Rats
chemical_list: D054439:Ghrelin; D007328:Insulin; D005947:Glucose
keywords: Gastrectomy; Gastric bypass; Glucose; Insulin; Type II diabetes