title: Survival analysis in patients with metastatic spinal disease: the influence of surgery, histology, clinical and neurologic status.
abstract: Spine is the most common site for skeletal metastasis in patients with malignancy. Vertebral involvement quantification, neurological status, general health status and primary tumor histology are factors to set surgical planning and therapeutic targets. We evaluated the impact of general clinical and neurological status, histologic type and surgery in survival.
  
  
  METHODS
  The study sample consisted of consecutive patients admitted from July 2010 to January 2013 for treatment.
  
  
  RESULTS
  Sixty eight patients were evaluated. 23 were female and 45 were male. Main primary neoplasic sites were: breast, prostate, lung/pleura and linfoproliferative. Thirty three out of 68 received surgical treatment, 2 received percutaneous biopsy and 33 had nonsurgical treatment.
  
  
  RESULTS
  Log Rank curves revealed no statistical significant difference according to histological type, surgical approach and Frankel Score. Karnofsky Score was statistically different.
  
  
  CONCLUSIONS
  Histological type and clinical status were statistically associated with life expectancy in vertebral metastatic disease.
authors.affiliation: Departamento de Neurocirurgia, Hospital do Servidor Público Estadual de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Matheus Fernandes de
authors.initials: MF
authors.lastname: Oliveira
authors.affiliation: Departamento de Neurocirurgia, Hospital do Servidor Público Estadual de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Jose Marcus
authors.initials: JM
authors.lastname: Rotta
authors.affiliation: Departamento de Neurocirurgia, Hospital do Servidor Público Estadual de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Ricardo Vieira
authors.initials: RV
authors.lastname: Botelho
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology; D008223:Lymphoma / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000401:mortality / Q000473:pathology; D010997:Pleural Neoplasms / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology; D013125:Spinal Neoplasms / Q000401:mortality* / Q000556:secondary* / Q000628:therapy; D018709:Statistics, Nonparametric; D015996:Survival Rate; D013997:Time Factors