title: Acute Generalized Exanthematous Pustulosis Induced by Amoxicillin/Clavulanic Acid: Report of a Case Presenting With Generalized Lymphadenopathy.
abstract: Drug-induced acute generalized exanthematous pustulosis is a rare pustular skin reaction, most commonly triggered by antibiotics. Although its diagnosis is based primarily on the presence of specific clinical and histopathologic features, additional in vivo (patch testing) or in vitro testing may be required, especially in atypical cases, to more accurately determine the causative agent. The authors report a histologically confirmed case of acute generalized exanthematous pustulosis that was induced by amoxicillin/clavulanic acid, as documented by subsequent patch testing, and presented with generalized painful lymphadenopathy, mimicking an acute infectious process. This is a very rare and diagnostically challenging clinical presentation of acute generalized exanthematous pustulosis, which has been reported, to the best of our knowledge, only once previously.
authors.affiliation: Allergy Department, "Sotiria" General Hospital, Athens, Greece.
authors.forename: Ekaterini
authors.initials: E
authors.lastname: Syrigou
authors.affiliation: 3rd Department of Medicine, Athens School of Medicine, "Sotiria" General Hospital, Athens, Greece dimgrap@yahoo.gr.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Grapsa
authors.affiliation: 3rd Department of Medicine, Athens School of Medicine, "Sotiria" General Hospital, Athens, Greece.
authors.forename: Andriani
authors.initials: A
authors.lastname: Charpidou
authors.affiliation: 3rd Department of Medicine, Athens School of Medicine, "Sotiria" General Hospital, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Syrigos
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis* / Q000209:etiology*; D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D010328:Patch Tests; D065093:beta-Lactamase Inhibitors / Q000009:adverse effects*
chemical_list: D065093:beta-Lactamase Inhibitors; D019980:Amoxicillin-Potassium Clavulanate Combination
keywords: AGEP; acute generalized exanthematous pustulosis; amoxicillin/clavulanic acid; patch tests; pustular skin eruption