title: Black hemostatic sponge based on facile prepared cross-linked graphene.
abstract: In this study, we demonstrate for the first time the remarkable hemostatic performance of a cross-linked graphene sponge (CGS) as a superb hemostat. The CGS can absorb plasma immediately (<40 ms) to form a blood cell layer and promotes subsequent clotting. The interaction between the interface of the CGS and blood cells reveals that the fast blood coagulation is primarily attributed to the enrichment of hemocytes and platelets on the wound surface. An in vitro dynamic whole-blood clotting test further highlights the effectiveness of the CGS. Considering the facile preparation, low cost, nontoxicity, and long shelf life of the portable black sponge, the CGS has great potential for trauma treatment.
authors.affiliation: The State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Kecheng
authors.initials: K
authors.lastname: Quan
authors.affiliation: The State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Guofeng
authors.initials: G
authors.lastname: Li
authors.affiliation: The State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Luan
authors.affiliation: The State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Qipeng
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Tao
authors.affiliation: The State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address: wangxing@mail.buct.edu.cn.
authors.forename: Xing
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D006108:Graphite / Q000737:chemistry*; D006490:Hemostatics; D006801:Humans; D008855:Microscopy, Electron, Scanning; D015503:Surgical Sponges
chemical_list: D006490:Hemostatics; D006108:Graphite
keywords: CGS; Clotting; Graphene; Hemostasis; Hemostatic sponge