title: Early diagnosis and successful treatment of Cryptococcus albidus keratitis: a case report and literature review.
abstract: Cryptococcus albidus keratitis is a rare and difficult diagnosed disease. Here we report a case of C albidus keratitis early diagnosed by dot hybridization assay and successfully treated with intrastromal injection of Amphotericin B (AB).A 45-year-old man presented with left red eye for 2 days. The slit lamp examination exhibited deep corneal infiltrations. Smears and cultures were performed but revealed negative findings. Molecular detection of pathogens was performed by dot hybridization assay, and C albidus keratitis was diagnosed. Despite the identification of C albidus, the clinical condition still worsened due to deep corneal infiltration. After performing intrastromal injection of AB, the corneal infiltration gradually improved.C albidus is a rare cause of diseases in humans and should be considered as a potential pathogen of corneal ulcer. The prognosis of C albidus keratitis will improve if the condition is recognized early and treated properly.
authors.affiliation: From the Department of Ophthalmology (Y-HH, I-HL, S-HT); and Department of Medical Laboratory Science and Biotechnology (T-CC), National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yi-Hsun
authors.initials: YH
authors.lastname: Huang
authors.forename: I-Huang
authors.initials: IH
authors.lastname: Lin
authors.forename: Tsung-Chain
authors.initials: TC
authors.lastname: Chang
authors.forename: Sung-Huei
authors.initials: SH
authors.lastname: Tseng
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000175:diagnosis* / Q000188:drug therapy*; D042241:Early Diagnosis; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B