title: [The basic strategies and research advances in the studies on glycosyltransferases involved in ginsenoside biosynthesis].
abstract: Traditional herbal medicines, Panax ginseng, Panax quinquefolium and Panax notoginseng, attract our attention for their extensive and powerful pharmacological activities. Ginsenosides are the main active constituents of these medicinal herbs. The related glycosyltransferases involved in ginsenoside biosynthesis are the key enzymes which catalyze the last important step. Modification of ginsenoside aglycones by glycosyltransferases produces the complexity and diversity of ginsenosides, which have more extensive pharmacological activity. At present, ginsenoside aglycones and compound K have been obtained by synthetic biology. As the last step of ginsenoside biosynthesis, glycosylation of ginsenoside aglycones has been studied intensively in recent years. This review summarizes the basic strategies and research advances in studies on glycosyltransferases involved in ginsenoside biosynthesis, which is expected to lay the theoretical foundation for the in-depth research of biosynthetic pathway of ginsenosides and their production by synthetic biology.
authors.forename: Hui-Chao
authors.initials: HC
authors.lastname: Liang
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Gong
authors.forename: Guo-Hua
authors.initials: GH
authors.lastname: Du
authors.forename: Jin-Ling
authors.initials: JL
authors.lastname: Yang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
mesh_terms: D053898:Biosynthetic Pathways; D036145:Ginsenosides / Q000096:biosynthesis*; D016695:Glycosyltransferases / Q000378:metabolism*; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D058615:Synthetic Biology
chemical_list: D036145:Ginsenosides; D016695:Glycosyltransferases