title: Characteristics and Fate of Systemic Artery Aneurysm after Kawasaki Disease.
abstract: OBJECTIVE
  To determine the long-term outcome of systemic artery aneurysms (SAAs) after Kawasaki disease (KD).
  
  
  METHODS
  We investigated the characteristics and the fate of SAAs in 20 patients using medical records and angiograms. The age of onset of KD ranged from 1 month to 20 months. The interval from the onset of KD to the latest angiogram ranged from 16 months to 24 years. The regression rate of peripheral artery aneurysm and the frequency of stenotic lesions were analyzed by the Kaplan-Meier method in 11 patients who had undergone initial angiography within 4 months.
  
  
  RESULTS
  The mean duration of fever was 24 ± 12 days. All 20 patients had at least 1 symmetric pair of aneurysms in bilateral peripheral arteries, and 16 patients had multiple SAAs. The distributions of SAAs was as follows: brachial artery, 30; common iliac artery, 20; internal iliac artery, 21; abdominal aortic aneurysm, 7; and others, 29. The frequencies of regression of SAA and of the occurrence of stenotic lesions at 20 years after the onset of KD were 51% and 25%, respectively (n = 42). The diameter of all SAAs in the acute phase leading to stenotic lesions in the late period was >10 mm.
  
  
  CONCLUSIONS
  SAAs occurred symmetrically and were multiple in younger infants and those with severe acute vasculitis. The fate of SAAs resembles that of coronary artery aneurysms, and depends on the diameter during the acute phase. Larger SAAs can lead to stenotic lesions in the late period.
authors.affiliation: Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan. Electronic address: pediatricsshiga@gmail.com.
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Hoshino
authors.affiliation: Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tsuda
authors.affiliation: Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamada
mesh_terms: D000367:Age Factors; D000783:Aneurysm / Q000000981:diagnostic imaging / Q000209:etiology*; D000792:Angiography; D001157:Arterial Occlusive Diseases / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D012189:Retrospective Studies; D012720:Severity of Illness Index