title: Bi(OTf)3-Catalyzed Multicomponent α-Amidoalkylation Reactions.
abstract: A bismuth(III) triflate catalyzed three-component synthesis of α-substituted amides starting from amides, aldehydes, and (hetero)arenes is reported. The reaction has a broad substrate scope, encompassing formaldehyde as well as aryl and alkyl aldehydes. Low catalyst loadings are required, and water is formed as the only side product. The scope and limitation of this method will be discussed.
authors.affiliation: Department of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, Frankfurt am Main D-60438, Germany.
authors.forename: Angelika E
authors.initials: AE
authors.lastname: Schneider
authors.affiliation: Department of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, Frankfurt am Main D-60438, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Manolikakes
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000447:Aldehydes; D000588:Amines; D001549:Benzamides; D007659:Ketones; D008698:Mesylates; C445789:Bi(OTf)3