title: Current radiosynthesis strategies for 5-HT2A receptor PET tracers.
abstract: Serotonin 2A receptors have been implicated in various psychophysiological functions and disorders such as depression, Alzheimer's disease, or schizophrenia. Therefore, neuroimaging of this specific receptor is of significant clinical interest, and it is not surprising that many attempts have been made to develop a suitable 5-HT2A R positron emission tomography-tracer. In this review, we give an overview on the precursor, reference compound synthesis, and the preparation of promising 5-HT2A R radiopharmaceuticals applied in positron emission tomography. We also highlight possible learning outcomes that can be made from these tracer development processes.
authors.affiliation: Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, Copenhagen, DK-2100, Denmark.|Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 160, Copenhagen, DK-2100, Denmark.
authors.forename: Matthias M
authors.initials: MM
authors.lastname: Herth
authors.affiliation: Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, Copenhagen, DK-2100, Denmark.
authors.forename: Gitte M
authors.initials: GM
authors.lastname: Knudsen
mesh_terms: D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000138:chemical synthesis*
chemical_list: D019275:Radiopharmaceuticals; D044402:Receptor, Serotonin, 5-HT2A; D012702:Serotonin Antagonists
keywords: (R)-[18F]MH.MZ; 5-HT2A; PET; [11C]Cimbi-36; [11C]MDL 100907; [18F]MDL 100907 [18F]altanserin; [18F]MH.MZ; [18F]RP62203; [18F]deuteroaltanserin; [18F]fananserin; tracer development