title: RAGE-ligands axis: A new 'driving force' for cigarette smoke-induced airway inflammation in COPD?
abstract: Receptor for advanced glycation end products (RAGE) was recently shown to contribute to cigarette smoke (CS)-induced airway inflammation in chronic obstructive pulmonary disease (COPD). In this study, RAGE small interfering ribonucleic acid (RNA) transfection attenuated increased messenger RNA levels of common RAGE ligands HMGB1, S100A8, S100A9 and S100A12, but not S100B following exposure to CS extract. Our findings and those from recent studies suggest a positive feedback involving RAGE and its ligands as a new 'driving force' for CS-induced airway inflammation in COPD.
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Guo
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.|Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.|Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Zenglin
authors.initials: Z
authors.lastname: Liao
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.|Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Wen
authors.affiliation: Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.|Department of Respiratory Medicine, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
mesh_terms: D040501:Calgranulin A / Q000502:physiology; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008024:Ligands; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D034741:RNA, Small Interfering / Q000502:physiology; D000067759:Receptor for Advanced Glycation End Products / Q000502:physiology*; D064568:S100 Calcium Binding Protein beta Subunit / Q000502:physiology; D009418:S100 Proteins / Q000502:physiology*; D000067616:S100A12 Protein / Q000502:physiology; D012907:Smoking / Q000009:adverse effects / Q000503:physiopathology*
chemical_list: D040501:Calgranulin A; D008024:Ligands; D034741:RNA, Small Interfering; D000067759:Receptor for Advanced Glycation End Products; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D000067616:S100A12 Protein; C579160:S100B protein, human
keywords: airway inflammation; cigarette smoke; receptor for advanced glycation end product; small interfering ribonucleic acid