title: Essential metals profile of the hair and nails of patients with laryngeal cancer.
abstract: Trace elements have an impact on numerous physiological processes. The monitoring of their levels in the organism allows you to detect not only their deficiencies, but also several illnesses. The aim of this study was to compare the levels of essential elements (calcium, magnesium, zinc, copper, iron, manganese) in hair, nails and serum of both patients with laryngeal cancer and healthy people. The determination of six metals was performed by an inductively coupled plasma mass spectrometry (ICP-MS) and an inductively coupled plasma optical emission spectrometry (ICP-OES). The concentration of essential elements in hair and nails of the control group was statistically significantly higher than in the group of patients with laryngeal cancer. In the case of serum, differences were found between the patients and controls in respect of the level of three metals. The results of principal component analysis (PCA) revealed the strong and similar clustering behavior of essential elements in hair and nails. The metals did not correlate between two alternative materials. The present study indicated that, using the level of essential elements in hair and nails as a basis, it is possible to distinguish cancer patients from healthy people. The alternative materials are independent of homeostasis and therefore seem to be more useful in the detection of diseases and mineral deficiencies in human than the classical biological materials, such as blood.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Golasik
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Przybyłowicz
authors.affiliation: Laboratory of Environmental Research, Department of Toxicology, University of Medical Sciences, Dojazd 30, 60-631 Poznań, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Woźniak
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Herman
authors.affiliation: Department of Otolaryngology and Laryngological Oncology, University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Gawęcki
authors.affiliation: Department of Otolaryngology and Laryngological Oncology, University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland; Greater Poland Cancer Center, Garbary 15, 61-866 Poznań, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Golusiński
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.
authors.forename: Stanisław
authors.initials: S
authors.lastname: Walas
authors.affiliation: Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Wojska Polskiego 28, 60-637 Poznań, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Krejpcio
authors.affiliation: Department of Otolaryngology and Laryngological Oncology, University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland; Clinic of Phoniatrics and Audiology, University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szyfter
authors.affiliation: Laboratory of Environmental Research, Department of Toxicology, University of Medical Sciences, Dojazd 30, 60-631 Poznań, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Florek
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland; Laboratory of High Resolution Mass Spectrometry, Regional Laboratory of Physicochemical Analysis and Structural Research, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland. Electronic address: wpiekosz@tlen.pl.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Piekoszewski
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000737:chemistry*; D008297:Male; D008670:Metals / Q000032:analysis* / Q000097:blood; D008875:Middle Aged; D009262:Nails / Q000737:chemistry*; D011044:Poland; D014131:Trace Elements / Q000032:analysis; D055815:Young Adult
chemical_list: D008670:Metals; D014131:Trace Elements
keywords: Hair; ICP; Laryngeal cancer; Nails; Serum; Trace elements