title: Gut satiety hormones and hyperemesis gravidarum.
abstract: Hyperemesis gravidarum (HG) is described as unexplained excessive nausea and vomiting during pregnancy. Some gut hormones that regulate appetite may have important role in etiopathogenesis of HG and weight changes during pregnancy. In this study, levels of gut satiety hormones were evaluated in pregnant women with HG.
  
  
  METHODS
  This prospective case-control study was conducted in 30 women with HG and 30 healthy pregnant women without symptoms of HG. Fasting venous blood samples were taken from all subjects for measurement of plasma gut hormone levels; obestatin (pg/mL), peptide YY (PYY), pancreatic polypeptide (PP) and cholecystokinin (CCK).
  
  
  RESULTS
  Plasma PYY and PP levels were significantly higher in HG group. The most important parameter in diagnosis of HG was plasma PP level. Simple use of PP level led to the diagnosis 91.1 % of HG cases correctly. The single most important parameter in the prediction of HG was also PP level.
  
  
  CONCLUSIONS
  Anorexigenic gut hormones might have important role in etiopathogenesis of hyperemesis gravidarum and weight changes during pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Özal University, Alparslan Türkeş cad. no:57, Ankara, 06510, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Köşüş
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Özal University, Alparslan Türkeş cad. no:57, Ankara, 06510, Turkey. nerminkosus@gmail.com.
authors.forename: Nermin
authors.initials: N
authors.lastname: Köşüş
authors.affiliation: Department of Obstetrics and Gynecology, Cengiz Gokcek State Hospital, Gaziantep, Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Usluoğullari
authors.affiliation: Department of Obstetrics and Gynecology, Turgut Özal University, Alparslan Türkeş cad. no:57, Ankara, 06510, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Hizli
authors.affiliation: Department of Biochemistry, Turgut Özal University, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Namuslu
authors.affiliation: Department of Biochemistry, Turgut Özal University, Ankara, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ayyildiz
mesh_terms: D000328:Adult; D001835:Body Weight; D016022:Case-Control Studies; D002766:Cholecystokinin / Q000097:blood*; D005215:Fasting; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood / Q000175:diagnosis*; D010191:Pancreatic Polypeptide / Q000097:blood*; D019894:Peptide YY / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D015430:Weight Gain; D055815:Young Adult
chemical_list: D054439:Ghrelin; D019894:Peptide YY; D010191:Pancreatic Polypeptide; D002766:Cholecystokinin
keywords: Emesis; Gut hormone; Pregnancy; Weight change