title: Simultaneous Multislice Accelerated Free-Breathing Diffusion-Weighted Imaging of the Liver at 3T.
abstract: OBJECTIVE
  To perform image quality comparison between accelerated multiband diffusion acquisition (mb2-DWI) and conventional diffusion acquisition (c-DWI) in patients undergoing clinically indicated liver MRI.
  
  
  METHODS
  In this prospective study 22 consecutive patients undergoing clinically indicated liver MRI on a 3-T scanner equipped to perform multiband diffusion-weighed imaging (mb-DWI) were included. DWI was performed with single-shot spin-echo echo-planar technique with fat-suppression in free breathing with matching parameters when possible using c-DWI, mb-DWI, and multiband DWI with a twofold acceleration (mb2-DWI). These diffusion sequences were compared with respect to various parameters of image quality, lesion detectability, and liver ADC measurements.
  
  
  RESULTS
  Accelerated mb2-DWI was 40.9% faster than c-DWI (88 vs. 149 s). Various image quality parameter scores were similar or higher on mb2-DWI when compared to c-DWI. The overall image quality score (averaged over the three readers) was significantly higher for mb-2 compared to c-DWI for b = 0 s/mm(2) (3.48 ± 0.52 vs. 3.21 ± 0.54; p = 0.001) and for b = 800 s/mm(2) (3.24 ± 0.76 vs. 3.06 ± 0.86; p = 0.010). Total of 25 hepatic lesions were visible on mb2-DWI and c-DWI, with identical lesion detectability. There was no significant difference in liver ADC between mb2-DWI and c-DWI (p = 0.12). Bland-Altman plot demonstrates lower mean liver ADC with mb2-DWI compared to c-DWI (by 0.043 × 10(-3) mm(2)/s or 3.7% of the average ADC).
  
  
  CONCLUSIONS
  Multiband technique can be used to increase acquisition speed nearly twofold for free-breathing DWI of the liver with similar or improved overall image quality and similar lesion detectability compared to conventional DWI.
authors.affiliation: Department of Radiology, New York University Langone Medical Center, 660 First Avenue, New York, NY, 10016, USA.
authors.forename: Chika C
authors.initials: CC
authors.lastname: Obele
authors.affiliation: Siemens HealthCare, New York, NY, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Glielmi
authors.affiliation: Department of Radiology, New York University Langone Medical Center, 660 First Avenue, New York, NY, 10016, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Ream
authors.affiliation: Department of Radiology, New York University Langone Medical Center, 660 First Avenue, New York, NY, 10016, USA.
authors.forename: Ankur
authors.initials: A
authors.lastname: Doshi
authors.affiliation: Department of Radiology, New York University Langone Medical Center, 660 First Avenue, New York, NY, 10016, USA.|Department of Radiology, Memorial Sloan Kettering, New York, NY, USA.
authors.forename: Naomi
authors.initials: N
authors.lastname: Campbell
authors.affiliation: Department of Radiology, New York University Langone Medical Center, 660 First Avenue, New York, NY, 10016, USA.
authors.forename: Hoi Cheung
authors.initials: HC
authors.lastname: Zhang
authors.affiliation: Department of Radiology, New York University Langone Medical Center, 660 First Avenue, New York, NY, 10016, USA.
authors.forename: James
authors.initials: J
authors.lastname: Babb
authors.affiliation: Siemens HealthCare, Charlestown, MA, USA.
authors.forename: Himanshu
authors.initials: H
authors.lastname: Bhat
authors.affiliation: Department of Radiology, New York University Langone Medical Center, 660 First Avenue, New York, NY, 10016, USA. hersh.chandarana@nyumc.org.
authors.forename: Hersh
authors.initials: H
authors.lastname: Chandarana
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011446:Prospective Studies; D015203:Reproducibility of Results; D012119:Respiration
keywords: Diffusion-weighted imaging; Liver MRI; Multiband DWI; Simultaneous multislice acceleration DWI