title: Predictive model of the prostate motion in the context of radiotherapy: A biomechanical approach relying on urodynamic data and mechanical testing.
abstract: In this paper, a biomechanical approach relying on urodynamic data and mechanical tests is proposed for an accurate prediction of the motion of the pelvic organs in the context of the prostate radiotherapy. As a first step, an experimental protocol is elaborated to characterize the mechanical properties of the bladder and rectum wall tissues; uniaxial tensile tests are performed on porcine substrates. In a second step, the parameters of Ogden-type hyperelastic constitutive models are identified; their relevance in the context of the implementation of a human biomechanical model is verified by means of preliminary Finite Elements (FE) simulations against human urodynamic data. In a third step, the identified constitutive equations are employed for the simulations of the motion and interactions of the pelvic organs due to concomitant changes of the distension volumes of the urinary bladder and rectum. The effectiveness of the developed biomechanical model is demonstrated in investigating the motion of the bladder, rectum and prostate organs; the results in terms of displacements are shown to be in good agreement with measurements inherent to a deceased person, with a relative error close to 6%.
authors.affiliation: L.E.M.T.A., Université de Lorraine, C.N.R.S., 54518 Vandoeuvre Cedex, France. Electronic address: bader.boubaker@gmail.com.
authors.forename: Mohamed Bader
authors.initials: MB
authors.lastname: Boubaker
authors.affiliation: L.S.P.M., U.P.R., C.N.R.S. 3407 Université Paris 13, 99, av. J-B. Clément, 93430 Villetaneuse, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Haboussi
authors.affiliation: L.E.M.T.A., Université de Lorraine, C.N.R.S., 2 avenue de la forêt de Haye, TSA 60604, 54518 Vandoeuvre CEDEX, France. Electronic address: jean-francois.ganghoffer@univ-lorraine.fr.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Ganghoffer
authors.affiliation: Centre Alexis Vautrin, C.R.A.N., I.N.P.L., C.N.R.S. 54500 Vandoeuvre Cedex, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Aletti
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000528:radiation effects; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D008422:Materials Testing; D055595:Mechanical Phenomena; D008875:Middle Aged; D008954:Models, Biological; D009068:Movement; D011467:Prostate / Q000502:physiology* / Q000528:radiation effects*; D011471:Prostatic Neoplasms / Q000503:physiopathology / Q000532:radiotherapy; D012007:Rectum / Q000502:physiology / Q000528:radiation effects; D013552:Swine; D001743:Urinary Bladder / Q000502:physiology / Q000528:radiation effects; D014563:Urodynamics / Q000528:radiation effects*
keywords: Finite element simulations; Mechanical characterization; Pelvic tissues; Prostate motion; Radiotherapy; Urodynamic data