title: [The changes in the biochemical indices of blood in cobalt intoxication on the background of the regulators of the expression of endothelial NO-synthase].
abstract: On the background of chronic cobalt intoxication in rats develops oxidative stress. This is accompanied by a decrease in the content of total metabolites of nitric oxide in the blood serum. The reasons for lower levels of the vasodilatation factor are the following: a deficiency of L-arginine and the increase in the content of the inhibitor of NOS-3. We found a decrease in the bioavailability of nitric oxide due to the increase in the content of oxidized low density lipids, total cholesterol and cholesterol-lowering lipids high density.
authors.forename: S G
authors.initials: SG
authors.lastname: Dzugkoev
authors.forename: I V
authors.initials: IV
authors.lastname: Mozhayeva
authors.forename: L B
authors.initials: LB
authors.lastname: Gigolaeva
authors.forename: A I
authors.initials: AI
authors.lastname: Tedtoeva
authors.forename: O I
authors.initials: OI
authors.lastname: Margieva
authors.forename: F S
authors.initials: FS
authors.lastname: Dzugkoeva
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001120:Arginine / Q000008:administration & dosage / Q000172:deficiency / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003035:Cobalt / Q000633:toxicity*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000008:administration & dosage / Q000494:pharmacology; D009569:Nitric Oxide / Q000097:blood*; D052250:Nitric Oxide Synthase Type III / Q000096:biosynthesis*; D018384:Oxidative Stress / Q000187:drug effects*; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014451:Ubiquinone; D009569:Nitric Oxide; D003035:Cobalt; D001120:Arginine; D002784:Cholesterol; D002374:Catalase; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D013482:Superoxide Dismutase; C024989:coenzyme Q10; C018021:cobaltous chloride; D019331:NG-Nitroarginine Methyl Ester