title: [Regional peculiarities of the distribution of innate and adaptive immune cells in different segments of the intestine as factor determining the localization of the pathological process].
abstract: The intestine represents the largest compartment of the immune system. Gut-associated lymphoid tissue (GALT) is a sensor region for luminal content and plays an important role in lymphoid maturation, activation and differentiation. We studied the regional peculiarities of the distribution of T-bet+ (Thl), GATA-3+ (Th2), RORγt+ (Th17), Foxp3+ (Treg) immunopositive lymphocytes and TLR2-, TLR4-, NOD- and RIG-like expression levels by lymphocytes of the gut-associated lymphoid tissue in the intestine of Wistar rats. The immunopositive lymphocytes were determined using an indirect immunofluorescence technique with using a monoclonal rat antibody. We have found regional differences distribution of immune cell populations along the length of the intestine.
authors.forename: A S
authors.initials: AS
authors.lastname: Zherebiatiev
authors.forename: A M
authors.initials: AM
authors.lastname: Kamyshnyi
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015415:Biomarkers; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D005786:Gene Expression Regulation / Q000276:immunology*; D007113:Immunity, Innate; D018928:Immunity, Mucosal; D007422:Intestines / Q000276:immunology* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers