title: Sero-prevalence of dengue infections in the Kassala state in the eastern part of the Sudan in 2011.
abstract: Dengue fever is a vector-borne disease that is transmitted to humans by infected Aedes aegypti mosquitoes. The eastern part of the Sudan is one of the regions that is affected by dengue virus circulation. In this study, we estimated the prevalence of dengue infections in the Kassala state in the eastern part of the Sudan. The study objective was to estimate the sero-prevalence of dengue IgG/IgM antibodies in the Kassala locality in 2011. This was a cross sectional community-based study that utilized a multi-stage cluster sampling technique regarding the probability sampling the study participants. Capture ELISA serological techniques were used for both IgM and IgG, with the specific cut-offs for each set by the manufacturer. The prevalence of dengue infection was found to be 9.4% (95% CI: 7.1-12.3). In conclusion, there is evidence that the dengue virus is being transmitted in Kassala. Disease surveillance, including the clinical, serological and entomological components, should be strengthened, and additional epidemiological studies are needed to better understand of the disease burden and effects in the area.
authors.affiliation: Directorate of Epidemiology and Zoonotic Diseases, Federal Ministry of Health, Khartoum, Sudan.
authors.forename: Sayed
authors.initials: S
authors.lastname: Himatt
authors.affiliation: Al Ribat University, Faculty of the Medicine Community Department, Sudan; Tiabah University, College of Medicine Family and Community Medicine, Saudi Arabia.
authors.forename: Kamal E
authors.initials: KE
authors.lastname: Osman
authors.affiliation: Emergency and Humanitarian Action, Federal Ministry of Health, Khartoum, Sudan.
authors.forename: Somia I
authors.initials: SI
authors.lastname: Okoued
authors.affiliation: Department of Medical Entomology, National Public Health Laboratory, Khartoum, Sudan.
authors.forename: Osama E
authors.initials: OE
authors.lastname: Seidahmed
authors.affiliation: Pediatric Dengue Vaccine Initiative, Republic of Korea.
authors.forename: Mark E
authors.initials: ME
authors.lastname: Beatty
authors.affiliation: Directorate of Epidemiology and Zoonotic Diseases, Federal Ministry of Health, Khartoum, Sudan. Electronic address: Soghaier@gmail.com.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Soghaier
authors.affiliation: Department of Epidemiology and Public Health Medicine, The Royal College of Surgeons in Ireland, Bahrain.
authors.forename: Khalifa
authors.initials: K
authors.lastname: Elmusharaf
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D003430:Cross-Sectional Studies; D003715:Dengue / Q000453:epidemiology*; D003716:Dengue Virus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013397:Sudan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M
keywords: Primary dengue; Surveillance; Vector borne disease