title: Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease.
abstract: OBJECTIVE
  To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD).
  
  
  METHODS
  Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD.
  
  
  RESULTS
  Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD.
  
  
  CONCLUSIONS
  These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134 Florence, Italy.
authors.forename: Amedeo
authors.initials: A
authors.lastname: Amedei
authors.affiliation: Dipartimento di Chirurgia e Medicina Traslazionale, Università di Firenze, Florence, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Pimpinelli
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134 Florence, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Grassi
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134 Florence, Italy.
authors.forename: Chiara Della
authors.initials: CD
authors.lastname: Bella
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134 Florence, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Niccolai
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134 Florence, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Brancati
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134 Florence, Italy.
authors.forename: Marisa
authors.initials: M
authors.lastname: Benagiano
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134 Florence, Italy.
authors.forename: Sofia
authors.initials: S
authors.lastname: D'Elios
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134 Florence, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Bosi
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134 Florence, Italy.
authors.forename: Mario M
authors.initials: MM
authors.lastname: D'Elios
keywords: Autoimmunity; CD30; Cytokines; Graft versus host disease; Systemic sclerosis