title: Pharmacokinetic interaction between etravirine or rilpivirine and telaprevir in healthy volunteers: A randomized, two-way crossover trial.
abstract: Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) may require treatment with an HIV non-nucleoside reverse transcriptase inhibitor (NNRTI), for example, rilpivirine or etravirine, and an HCV direct-acting antiviral drug such as telaprevir. In a two-panel, two-way, crossover study, healthy volunteers were randomized to receive etravirine 200 mg twice daily ± telaprevir 750 mg every 8 hours or rilpivirine 25 mg once daily ± telaprevir 750 mg every 8 hours. Pharmacokinetic assessments were conducted for each drug at steady-state when given alone and when coadministered; statistical analyses were least-square means with 90% confidence intervals. Telaprevir minimum plasma concentration (Cmin), maximum plasma concentration (Cmax), and area under the concentration-time curve (AUC) decreased 25%, 10%, and 16%, respectively, when coadministered with etravirine and 11%, 3%, and 5%, respectively, when coadministered with rilpivirine. Telaprevir did not affect etravirine pharmacokinetics, but increased rilpivirine Cmin, Cmax, and AUC by 93%, 49%, and 78%, respectively. Both combinations were generally well tolerated. The small decrease in telaprevir exposure when coadministered with etravirine is unlikely to be clinically relevant. The interaction between telaprevir and rilpivirine is not likely to be clinically relevant under most circumstances. No dose adjustments are deemed necessary when they are coadministered.
authors.affiliation: Janssen Research and Development, LLC, Titusville, NJ, USA.
authors.forename: Thomas N
authors.initials: TN
authors.lastname: Kakuda
authors.affiliation: Janssen Research and Development, LLC, Titusville, NJ, USA.
authors.forename: Lorant
authors.initials: L
authors.lastname: Leopold
authors.affiliation: Janssen Infectious Diseases BVBA, Beerse, Belgium.
authors.forename: Steven
authors.initials: S
authors.lastname: Nijs
authors.affiliation: Janssen Infectious Diseases BVBA, Beerse, Belgium.
authors.forename: Ann
authors.initials: A
authors.lastname: Vandevoorde
authors.affiliation: Janssen Infectious Diseases BVBA, Beerse, Belgium.
authors.forename: Herta M
authors.initials: HM
authors.lastname: Crauwels
authors.affiliation: Janssen Research and Development, LLC, Titusville, NJ, USA.
authors.forename: Kirk M
authors.initials: KM
authors.lastname: Bertelsen
authors.affiliation: Janssen Infectious Diseases BVBA, Beerse, Belgium.
authors.forename: Marita
authors.initials: M
authors.lastname: Stevens
authors.affiliation: Janssen Research and Development, LLC, Titusville, NJ, USA.
authors.forename: James
authors.initials: J
authors.lastname: Witek
authors.affiliation: Janssen, Tilburg, The Netherlands.
authors.forename: Yvon
authors.initials: Y
authors.lastname: van Delft
authors.affiliation: Janssen Research and Development, LLC, Titusville, NJ, USA.
authors.forename: Frank
authors.initials: F
authors.lastname: Tomaka
authors.affiliation: Janssen Infectious Diseases BVBA, Beerse, Belgium.
authors.forename: Richard M W
authors.initials: RM
authors.lastname: Hoetelmans
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D018592:Cross-Over Studies; D004347:Drug Interactions; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D009842:Oligopeptides / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D011724:Pyridazines / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D011743:Pyrimidines / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D000068696:Rilpivirine; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D009570:Nitriles; D009842:Oligopeptides; D011724:Pyridazines; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors; C451734:etravirine; C486464:telaprevir; D000068696:Rilpivirine
keywords: drug–drug interaction; etravirine; non‐nucleoside reverse transcriptase inhibitor; pharmacokinetics; rilpivirine; telaprevir