title: MicroRNAs and cell cycle of malignant glioma.
abstract: The control of malignant glioma cell cycle by microRNAs (miRNAs) is well established. The deregulation of miRNAs in glioma may contribute to tumor proliferation by directly targeting the critical cell-cycle regulators. Tumor suppressive miRNAs inhibit cell cycle through repressing the expression of positive cell-cycle regulators. However, oncogenic miRNAs promote the cell-cycle progression by targeting cell-cycle negative regulators. Recent studies have identified that transcription factors had involved in the expression of miRNAs. Transcription factors and miRNAs are implicated in regulatory network of glioma cell cycle, the deregulation of these transcription factors might be a cause of the deregulation of miRNAs. Abnormal versions of miRNAs have been implicated in the cell cycle of glioma. Based on those, miRNAs are excellent biomarker candidates and potential targets for therapeutic intervention in glioma.
authors.affiliation: a Department of Neurosurgery, Daping Hospital & Research Institute of Surgery , Third Military Medical University , Chongqing , China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ouyang
authors.affiliation: a Department of Neurosurgery, Daping Hospital & Research Institute of Surgery , Third Military Medical University , Chongqing , China.
authors.forename: Lunshan
authors.initials: L
authors.lastname: Xu
authors.affiliation: b State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology , Southwest University , Chongqing , China.
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Cui
authors.affiliation: a Department of Neurosurgery, Daping Hospital & Research Institute of Surgery , Third Military Medical University , Chongqing , China.
authors.forename: Minhui
authors.initials: M
authors.lastname: Xu
authors.affiliation: a Department of Neurosurgery, Daping Hospital & Research Institute of Surgery , Third Military Medical University , Chongqing , China.
authors.forename: Liang
authors.initials: L
authors.lastname: Yi
mesh_terms: D014408:Biomarkers, Tumor; D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000096:biosynthesis / Q000235:genetics; D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology; D004261:DNA Replication; D004273:DNA, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D016193:G1 Phase / Q000235:genetics; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D016328:NF-kappa B / Q000502:physiology; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology; D012334:RNA, Neoplasm / Q000235:genetics*; D016196:S Phase / Q000235:genetics; D014157:Transcription Factors / Q000502:physiology; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D004273:DNA, Neoplasm; D035683:MicroRNAs; D016328:NF-kappa B; D009363:Neoplasm Proteins; D016271:Proto-Oncogene Proteins c-myc; D012334:RNA, Neoplasm; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins
keywords: Glioma; biomarkers; cell cycle; microRNAs; transcription factor