title: LKB1 Inactivation Promotes ROS-Induced Plasticity in NSCLC.
abstract: LKB1 inactivation generates a redox imbalance that promotes ADC-to-SCC transdifferentiation in NSCLC.
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000473:pathology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology*; D051379:Mice; D009374:Neoplasms, Experimental; D017346:Protein Serine-Threonine Kinases / Q000172:deficiency*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases