title: Organocatalytic enantio- and diastereoselective synthesis of highly substituted δ-lactones via a Michael-cyclization cascade.
abstract: An organocatalyzed Michael-cyclization cascade approach of readily available α,β-unsaturated aldehydes and pyrazoleamides has been developed to get highly substituted δ-lactones in excellent enantioselectivities (up to 97%) and diastereoselectivities. The δ-lactones so obtained could easily be transformed into benzazepine derivatives with excellent enantio- and diastereoselectivities. Furthermore, the pyrazole moiety from the δ-lactones can be simply cleaved without disturbing the stereoselectivity.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal-462 066, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Agrawal
authors.forename: Nagaraju
authors.initials: N
authors.lastname: Molleti
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh