title: Parenteral nutrition-associated liver disease and lipid emulsions.
abstract: Parenteral nutrition-associated liver disease (PNALD) is a particularly important problem in patients who need this type of nutritional support for a long time. Prevalence of the condition is highly variable depending on the series, and its clinical presentation is different in adults and children. The etiology of PNALD is not well defined, and participation of several factors at the same time has been suggested. When a bilirubin level >2 mg/dl is detected for a long time, other causes of liver disease should be ruled out and risk factors should be minimized. The composition of lipid emulsions used in parenteral nutrition is one of the factors related to PNALD. This article reviews the different types of lipid emulsions and the potential benefits of emulsions enriched with omega-3 fatty acids.
authors.affiliation: Sección de Nutrición Clínica y Dietética, Complejo Hospitalario de Navarra, Pamplona, España. Electronic address: ana.zugasti.murillo@cfnavarra.es.
authors.forename: Ana
authors.initials: A
authors.lastname: Zugasti Murillo
authors.affiliation: Sección de Nutrición Clínica y Dietética, Complejo Hospitalario de Navarra, Pamplona, España.
authors.forename: Estrella
authors.initials: E
authors.lastname: Petrina Jáuregui
authors.affiliation: Servicio de Farmacia, Complejo Hospitalario de Navarra, Pamplona, España.
authors.forename: Javier
authors.initials: J
authors.lastname: Elizondo Armendáriz
mesh_terms: D005217:Fat Emulsions, Intravenous / Q000009:adverse effects* / Q000145:classification; D006801:Humans; D008107:Liver Diseases / Q000209:etiology*; D010288:Parenteral Nutrition / Q000009:adverse effects*
chemical_list: D005217:Fat Emulsions, Intravenous
keywords: Emulsión lipídica ácidos grasos omega-3; Fish oil-based lipid emulsion; Hepatopatía asociada a nutrición parenteral; Omegaven; Parenteral nutrition asociated liver disease