title: Consanguinity Protecting Effect Against Breast Cancer among Tunisian Women: Analysis of BRCA1 Haplotypes.
abstract: The purpose of this study is to assess the effect of consanguinity on breast cancer incidence in Tunisia. We conducted a case-control study to evaluate the involvement of heterozygote and homozygote haplotypes of BRCA1 gene SNPs according to consanguinity among 40 cases of familial breast cancer, 46 cases with sporadic breast cancer and 34 healthy controls. We showed significant difference in consanguinity rate between breast cancer patients versus healthy controls P = 0.001. Distribution of homozygous BRCA1 haplotypes among healthy women versus breast cancer patients was significantly different; p=0.02. Parental consanguinity seems to protect against breast cancer in the Tunisian population.
authors.affiliation: Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, University El Manar, Tunisia E-mail : imen.medimegh@gmail.com.
authors.forename: Imen
authors.initials: I
authors.lastname: Medimegh
authors.forename: Wafa
authors.initials: W
authors.lastname: Troudi
authors.forename: Ines
authors.initials: I
authors.lastname: Omrane
authors.forename: Hajer
authors.initials: H
authors.lastname: Ayari
authors.forename: Nancy
authors.initials: N
authors.lastname: Uhrhummer
authors.forename: Hamdi
authors.initials: H
authors.lastname: Majoul
authors.forename: Farhat
authors.initials: F
authors.lastname: Benayed
authors.forename: Amel
authors.initials: A
authors.lastname: Mezlini
authors.forename: Yves-Jean
authors.initials: YJ
authors.lastname: Bignon
authors.forename: Catherine
authors.initials: C
authors.lastname: Sibille
authors.forename: Amel Benammar
authors.initials: AB
authors.lastname: Elgaaied
mesh_terms: D000328:Adult; D000368:Aged; D019313:BRCA1 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control; D016022:Case-Control Studies; D003241:Consanguinity; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D011446:Prospective Studies; D014416:Tunisia / Q000453:epidemiology; D055815:Young Adult
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human