title: Clinical Experience with Pulse Dose Rate Brachytherapy for Conservative Treatment of Penile Carcinoma and Comparison with Historical Data of Low Dose Rate Brachytherapy.
abstract: OBJECTIVE
  To assess the efficacy of pulse dose rate (PDR) interstitial brachytherapy in the treatment of carcinoma of the penis and to compare with historical data of low dose rate (LDR) brachytherapy.
  
  
  METHODS
  We reviewed the clinical records of 27 consecutive patients treated in our institution with exclusive PDR brachytherapy for a squamous cell carcinoma of the penis. The median tumour greatest diameter was 20 mm (range: 10-50 mm). Twenty-three patients (85%) had tumours limited to the glans and/or prepuce and four patients (15%) also had inguinal lymph node metastases. Implantations were carried out according to the Paris system and treatments were delivered with PDR brachytherapy.
  
  
  RESULTS
  The median brachytherapy dose was 60 Gy (range: 60-70 Gy). The median treated volume was 28 cm(3) (range: 8-62 cm(3)). The median reference isodose rate was 0.4 Gy/pulse/h (range: 0.4-0.5 Gy/pulse/h). The median number of pulses was 150 (range: 120-175 pulses). With a median follow-up of 33 months (range: 6-64 months), tumour relapses in the penis were reported in four patients (15%). All patients with only local relapse (n = 3) were successfully salvaged with partial amputation. The estimated overall survival rate at 3 years was 95% (95% confidence interval: 83-100%). No grade 3 or more acute reaction was observed. Delayed ulcerations and stenoses requiring at least one meatal dilatation were reported in two (9%) and five (22%) patients without local relapse. The treated volume was significantly correlated to the risk of clinically relevant delayed toxicity.
  
  
  CONCLUSIONS
  The efficacy/toxicity results of PDR brachytherapy for the treatment of penile carcinoma are comparable with those obtained with LDR brachytherapy in historical cohorts.
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France.
authors.forename: L
authors.initials: L
authors.lastname: Kamsu-Kom
authors.affiliation: Department of Medical Imaging, Institut Gustave Roussy, Villejuif, France.
authors.forename: F
authors.initials: F
authors.lastname: Bidault
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France.
authors.forename: R
authors.initials: R
authors.lastname: Mazeron
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France.
authors.forename: C
authors.initials: C
authors.lastname: Baratiny
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France.
authors.forename: V
authors.initials: V
authors.lastname: Martin
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France.
authors.forename: P
authors.initials: P
authors.lastname: Maroun
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France.
authors.forename: I
authors.initials: I
authors.lastname: Dumas
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France.
authors.forename: A
authors.initials: A
authors.lastname: Guemnie-Tafo
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France.
authors.forename: F
authors.initials: F
authors.lastname: Martinetti
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France.
authors.forename: A
authors.initials: A
authors.lastname: Gerbaulet
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France; Department of Radiotherapy, HIA du Val-de-Grâce, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Chargari
authors.affiliation: Department of Radiotherapy, Brachytherapy Service, Institut Gustave Roussy, Villejuif, France. Electronic address: christine.haiemeder@gustaveroussy.fr.
authors.forename: C
authors.initials: C
authors.lastname: Haie-Meder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010412:Penile Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016019:Survival Analysis
keywords: Efficacy; low dose rate brachytherapy; penile carcinoma; pulse dose rate brachytherapy; toxicity