title: The design of a spiro-pyrrolidine organocatalyst and its application to catalytic asymmetric Michael addition for the construction of all-carbon quaternary centers.
abstract: A novel chiral spiro-pyrrolidine silyl ether organocatalyst has been designed. Its catalytic asymmetric effect is demonstrated by the Michael addition reaction, which affords the desired products with an all-carbon quaternary center in up to 99% ee and 87% yield. Furthermore, the reaction process has been investigated via in situ NMR experiments.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China. tuyq@lzu.edu.cn.
authors.forename: Jin-Miao
authors.initials: JM
authors.lastname: Tian
authors.forename: Yong-Hai
authors.initials: YH
authors.lastname: Yuan
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Tu
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Zhang
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Zhang
authors.forename: Shi-Heng
authors.initials: SH
authors.lastname: Zhang
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wang
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhang