title: Efficacy of a microballoon catheter in transarterial chemoembolization of hepatocellular carcinoma using miriplatin, a lipophilic anticancer drug: Short-term results.
abstract: OBJECTIVE
  The goal of the study was to evaluate the efficacy and safety of balloon-occluded transarterial chemoembolization (B-TACE) of hepatocellular carcinoma (HCC) using miriplatin (a lipophilic anticancer drug) and gelatin particles.
  
  
  METHODS
  B-TACE was performed for 62 HCC nodules in 33 patients who could not be treated by surgical resection or radiofrequency ablation. All 33 patients had a history of transarterial chemoembolization (TACE) treatment prior to B-TACE. As a historical comparison, we investigated 40 nodules in 28 patients treated by TACE using a conventional microcatheter (C-TACE), miriplatin and gelatin particles. The therapeutic effect per tumor was compared between the groups based on the Response Evaluation Criteria in Cancer Study Group of Japan (RECICL) and side-effects were compared based on the Common Terminology Criteria for Adverse Events (ver. 4.0).
  
  
  RESULTS
  The therapeutic efficacy after 4-12 weeks was evaluated in 59 nodules in the B-TACE group and in 37 nodules in the C-TACE group. Of these nodules, TE4 occurred in 29 (49.2%) in the B-TACE group and in 10 (27%) in the C-TACE group. Local efficacy was significantly higher in nodules treated by B-TACE than by C-TACE. The side-effects on hepatic function were similar in the two groups.
  
  
  CONCLUSIONS
  Our results suggest that B-TACE with miriplatin is a useful treatment for hepatocellular carcinoma.
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ogawa
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takayasu
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Midori
authors.initials: M
authors.lastname: Hirayama
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Takao
authors.initials: T
authors.lastname: Miura
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Shiozawa
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Masahisa
authors.initials: M
authors.lastname: Abe
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsumoto
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakagawara
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Shu
authors.initials: S
authors.lastname: Ohshiro
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Naohide
authors.initials: N
authors.lastname: Tanaka
authors.affiliation: Department of Gastroenterology and Hepatology.
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Moriyama
authors.affiliation: Radiology, Nihon University School of Medicine.
authors.forename: Haruomi
authors.initials: H
authors.lastname: Mutou
authors.affiliation: Department of Internal Medicine, Takenotsuka Clinic, Tokyo, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Yamamoto
authors.affiliation: Department of Radiology, Hitachi General Hospital, Hitachi, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Irie
keywords: balloon occlusion; balloon-occluded transarterial chemoembolization; conventional microcatheter transcatheter arterial chemoembolization; embolization; hepatocellular carcinoma; miriplatin