title: Role of hypofractionated radiotherapy in breast locoregional radiation.
abstract: Long-term results of randomised trials have confirmed the safety and efficacy of hypofractionated radiotherapy using approximately 2.6 Gy per fraction to lower total doses of 40-42.6 Gy delivered over 3 weeks, for postoperative treatment of early breast cancer. In these trials, hypofractionated radiotherapy was predominantly used for breast only treatment, while there are fewer trials that specifically examined hypofractionated radiotherapy to the breast plus regional nodes. Hypofractionated locoregional radiation is considered a standard of care in the United Kingdom and in some parts of Canada. We aim to review the radiobiology and normal tissue effects of hypofractionated locoregional radiation and to summarize available published clinical experiences using this treatment strategy as adjuvant therapy after breast conserving surgery or mastectomy for women with early breast cancer.
authors.affiliation: Department of Radiation Medicine, The Ottawa Hospital Cancer Centre, 501 Smyth Road, Ottawa, Ontario, K1H 8L6, Canada. Electronic address: jcaudrelier@toh.on.ca.
authors.forename: J-M
authors.initials: JM
authors.lastname: Caudrelier
authors.affiliation: Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Island Centre, Victoria, British Columbia, Canada.
authors.forename: P T
authors.initials: PT
authors.lastname: Truong
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy*; D002319:Cardiovascular System / Q000528:radiation effects; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008208:Lymphatic System / Q000528:radiation effects; D009420:Nervous System / Q000528:radiation effects
keywords: Breast cancer; Cancer du sein; Hypofractionated; Hypofractionnement; Irradiation ganglionnaires; Regional nodal radiation