title: Short communication-Evaluation of antianxiety and antidepressant properties of Carthamus tinctorius L. (Safflower) petal extract.
abstract: Nowadays anxiety and depression are most commonly encountered diseases. They are not only difficult to diagnose but even difficult to treat since both are sometimes seen together or one predisposes the other. Apart from this side effect profile of these drugs is also high; hence there is immense scope for the herbal drugs to treat these disorders. Present study was therefore performed to evaluate the antianxiety and antidepressant effect of Carthamus tinctorius petal extract. 28 white albino rats bred in the animal house of Department of Pharmacology, University of Karachi weighing 180-220gm were randomly divided into four groups (n=7/group) to assess behavioral effects. The anxiolytic and antidepressant effects of Carthamus tinctorius petal extract were evaluated using elevated plus maize and forced swim test respectively at100 and 200mg/kg. These effects were compared with standard drugs Diazepam (anxiolytic) 2mg/kg and Nortriptyline (antidepressant) 12.5mg/kg. Results show that CT produced highly significant anxiolytic and anti-depressant effects at both doses as compared to control, similar to standard anxiolytic and antidepressant drugs diazepam and nortriptyline. It increased the latency of first entry to closed arms and the time spent in open arms very significantly at both doses while entries to open arm were increased significantly at 100mg/kg and very significantly at 200mg/kg in EPM test and increased the immobility time very significantly in FST. Hence it can be concluded that CT may be used as an alternative therapeutic agent while treating patients with anxiety and depressive disorders.
authors.affiliation: Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
authors.forename: Nasreen
authors.initials: N
authors.lastname: Qazi
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Rafeeq Alam
authors.initials: RA
authors.lastname: Khan
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Ghazala H
authors.initials: GH
authors.lastname: Rizwani
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D031187:Carthamus tinctorius; D035264:Flowers; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D013315:Stress, Psychological; D013550:Swimming
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D010936:Plant Extracts