title: Plasma metabolomic profiling of patients with diabetes-associated cognitive decline.
abstract: Diabetes related cognitive dysfunction (DACD), one of the chronic complications of diabetes, seriously affect the quality of life in patients and increase family burden. Although the initial stage of DACD can lead to metabolic alterations or potential pathological changes, DACD is difficult to diagnose accurately. Moreover, the details of the molecular mechanism of DACD remain somewhat elusive. To understand the pathophysiological changes that underpin the development and progression of DACD, we carried out a global analysis of metabolic alterations in response to DACD. The metabolic alterations associated with DACD were first investigated in humans, using plasma metabonomics based on high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and multivariate statistical analysis. The related pathway of each metabolite of interest was searched in database online. The network diagrams were established KEGGSOAP software package. Receiver operating characteristic (ROC) analysis was used to evaluate diagnostic accuracy of metabolites. This is the first report of reliable biomarkers of DACD, which were identified using an integrated strategy. The identified biomarkers give new insights into the pathophysiological changes and molecular mechanisms of DACD. The disorders of sphingolipids metabolism, bile acids metabolism, and uric acid metabolism pathway were found in T2DM and DACD. On the other hand, differentially expressed plasma metabolites offer unique metabolic signatures for T2DM and DACD patients. These are potential biomarkers for disease monitoring and personalized medication complementary to the existing clinical modalities.
authors.affiliation: Academy of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Academy of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Traditional Chinese Medicine, the Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China; Academy of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Libin
authors.initials: L
authors.lastname: Zhan
authors.affiliation: Department of Emergency Medicine, Zhongshan Hospital, Dalian University, Dalian, Liaoning, China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Lu
authors.affiliation: Academy of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of endocrinology, the Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Benli
authors.initials: B
authors.lastname: Su
authors.affiliation: Academy of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Sui
authors.affiliation: Department of endocrinology, Dalian Municipal Central Hospital Affillated of Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Zhengnan
authors.initials: Z
authors.lastname: Gao
authors.affiliation: Examination Department, the Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Yuzhong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Medical Examination Center, the Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Medical Examination Center, the Second Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Benhui
authors.initials: B
authors.lastname: Wu
authors.affiliation: Public Health, Dalian Medical University, Dalian, Liaoning, China.
authors.forename: Qigui
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000368:Aged; D019540:Area Under Curve; D001647:Bile Acids and Salts / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D003072:Cognition Disorders / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D055442:Metabolome; D008875:Middle Aged; D015999:Multivariate Analysis; D025341:Principal Component Analysis; D012372:ROC Curve; D013107:Sphingolipids / Q000378:metabolism; D053719:Tandem Mass Spectrometry; D014527:Uric Acid / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D015415:Biomarkers; D013107:Sphingolipids; D014527:Uric Acid