title: T-Cell Activation and Malnutrition Adversely Impact on Endothelial Progenitor Cell Mobilization in Patients on Extracorporeal Maintenance Dialysis Therapy.
abstract: BACKGROUND
  The number of circulating endothelial progenitor cells (EPCs) decreases on account of chronic kidney disease (CKD).
  
  
  METHODS
  Twenty patients were enrolled in this prospective and randomised study in two parallel arms: conventional haemodialysis versus online haemodiafiltration. EPCs number and T-cell activation were analysed at baseline and monthly during a 4-month period of follow-up.
  
  
  RESULTS
  CD38(bright) and HLA-DR+ expression among CD8 memory T cells were negatively associated with both CD34+ (r = -0.70, p = 0.0006) and CD34+ CD133+ (r = -0.62, p = 0.004) cell numbers. Conversely, a positive correlation was observed between CD34+ and CD34+ CD133+ cells with transferrin (r = 0.75, p = 0.0001 and r = 0.47, p = 0.04, respectively), and CD34+ CD133+ cells with transthyretin (r = 0.51, p = 0.02). No significant association was observed between dialysis modality and the evolution of the EPC number.
  
  
  CONCLUSIONS
  Chronic T-cell activation may be a component of the malnutrition inflammation complex syndrome that adversely influences EPC mobilization in CKD patients.
authors.affiliation: Département de Bactériologie-Virologie and Institut de Médecine Régénératrice et de Biothérapie, CHRU de Montpellier, Montpellier, France.
authors.forename: Edouard
authors.initials: E
authors.lastname: Tuaillon
authors.forename: Isabelle
authors.initials: I
authors.lastname: Jaussent
authors.forename: Marion
authors.initials: M
authors.lastname: Morena
authors.forename: Annie
authors.initials: A
authors.lastname: Rodrigez
authors.forename: Leila
authors.initials: L
authors.lastname: Chenine
authors.forename: Nils
authors.initials: N
authors.lastname: Kuster
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vendrell
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.forename: Bernard
authors.initials: B
authors.lastname: Canaud
mesh_terms: D015415:Biomarkers; D002452:Cell Count; D066026:Endothelial Progenitor Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism* / Q000628:therapy; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology*; D044342:Malnutrition; D009752:Nutritional Status; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D015415:Biomarkers