title: Prognostic value of sST2 and galectin-3 for death relative to renal function in patients hospitalized for heart failure.
abstract: OBJECTIVE
  To evaluate the associations of soluble ST2 (sST2) and galectin-3 with death relative to renal function in patients with heart failure (HF).
  
  
  METHODS
  Eleven-hundred-and-sixty-one patients hospitalized for HF with 1-year follow up were enrolled for biomarkers analysis.
  
  
  RESULTS
  Patients were divided into two groups based on eGFR of either > or ≤60 ml/min/1.73 m(2). sST2 was independently associated with death in both categories of renal function, while galectin-3 lost this significance after addition of NT-proBNP to the model of patients with eGFR ≤60 ml/min/1.73 m(2).
  
  
  CONCLUSIONS
  In patients with HF, sST2 improved prediction for death beyond risk factors without being influenced by renal function, however, the prognostic value of galectin-3 is less clear below an eGFR of 60 ml/min/1.73 m(2).
authors.forename: Rongcheng
authors.initials: R
authors.lastname: Zhang
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: An
authors.forename: Xiao
authors.initials: X
authors.lastname: Guo
authors.forename: Shijie
authors.initials: S
authors.lastname: Yin
authors.forename: Yunhong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 2Division of Cardiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Januzzi
authors.affiliation: 3Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Cappola
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D037502:Galectin 3 / Q000097:blood*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006333:Heart Failure / Q000097:blood* / Q000401:mortality / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D000072179:Interleukin-1 Receptor-Like 1 Protein; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000097:blood*
chemical_list: D015415:Biomarkers; D037502:Galectin 3; C079241:IL1RL1 protein, human; D000072179:Interleukin-1 Receptor-Like 1 Protein; D011956:Receptors, Cell Surface
keywords: NT-proBNP; biomarker; cardiac remodeling; death; eGFR; galectin-3; heart failure; prognosis; renal function; sST2