title: Effect of crocin on oxidative stress in recovery from single bout of swimming exercise in rats.
abstract: Physical exercise could cause muscle and tissue damage due to increase in the formation of free oxygen radicals during exercise. The aim of the present study was to investigate the effect of crocin on parameters associated with oxidative stress in recovery from acute swimming exercise in rats. Rats were divided into eight groups; Normal Control (NC: untreated and did not swim), Crocin Control (CC: received crocin and did not swim), Exercise-1 (Exe-1: untreated and swam), Exercise-24 (Exe-24: untreated and swam), Exercise-48 (Exe-48: untreated and swam), Exercise+Crocin-1 (Exe-Cro-1: received crocin and swam), Exercise+Crocin-24 (Exe-Cro-24: received crocin and swam), Exercise+Crocin-48 (Exe-Cro-48: received crocin and swam). AST, ALP, LDH, CK, XO enzymes levels increased after swimming in untreated and crocin-treated groups, but there was a less increase in crocin-treated groups. The highest MDA levels in serum were determined in Exe-1 compared with all other groups. There was significant difference between control and exercise groups in MDA level (p = 0.033). In contrast, there was significant difference between control and exercise groups in GSH level (p < 0.001). In addition, crocin given to swimming rats significantly increased GSH levels (p < 0.05) and decreased MDA levels when compared with untreated exercise groups. In conclusion, crocin is able to protect liver and skeletal muscle tissue against exercise-induced oxidative damage by preventing reactive oxygen species (ROS) production.
authors.affiliation: Department of Medical Biochemistry, Medical Faculty, Karabuk University, Karabuk, Turkey. eyupaltinoz@karabuk.edu.tr.
authors.forename: Eyup
authors.initials: E
authors.lastname: Altinoz
authors.forename: Tarık
authors.initials: T
authors.lastname: Ozmen
authors.forename: Zulal
authors.initials: Z
authors.lastname: Oner
authors.forename: Hulya
authors.initials: H
authors.lastname: Elbe
authors.forename: Mehmet E
authors.initials: ME
authors.lastname: Erdemli
authors.forename: Harika G
authors.initials: HG
authors.lastname: Bag
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002338:Carotenoids / Q000494:pharmacology*; D005260:Female; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000379:methods; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000097:blood*; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology*; D013550:Swimming / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D002338:Carotenoids; C029036:crocin