title: Epstein-Barr virus-associated gastric carcinoma 33 years after kidney transplantation.
abstract: Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a unique type of gastric cancer, defined as the presence of EBV in gastric tumour cells, usually identified by in situ hybridization. A poorly differentiated gastric adenocarcinoma was detected in a kidney recipient 33 years after transplantation. Neoplastic epithelial cells were EBV positive by in situ hybridization. Gene sequencing confirmed the amplicon specificity, and real-time polymerase chain reaction quantified 2 600 000 genomes/μL DNA in neoplastic tissue. No cases of EBVaGC have been reported in solid organ transplants, thus this is the first case of de novo EBVaGC arising in a 65-year-old renal transplant recipient.
authors.affiliation: Department of Diagnostic Medical Sciences and Special Therapies.
authors.forename: Francesca
authors.initials: F
authors.lastname: Lunardi
authors.affiliation: Department of Diagnostic Medical Sciences and Special Therapies.
authors.forename: Fiorella
authors.initials: F
authors.lastname: Calabrese
authors.affiliation: Department of General Surgery and Organ Transplantation , University of Padua , Padua , Italy.
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Furian
authors.affiliation: Department of General Surgery and Organ Transplantation , University of Padua , Padua , Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Rigotti
authors.affiliation: Department of Diagnostic Medical Sciences and Special Therapies.
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Valente
keywords: Epstein–Barr virus; gastric cancer; kidney transplantation; molecular analyses