title: [Cell cycle regulation in cancer stem cells].
abstract: In addition to the properties of self-renewal and multipotency, cancer stem cells share the characteristics of their distinct cell cycle status with somatic stem cells. Cancer stem cells (CSCs) are maintained in a quiescent state with this characteristic conferring resistance to anticancer therapies that target dividing cells. Elucidation of the mechanisms of CSC quiescence might therefore be expected to provide further insight into CSC behaviors and lead to the elimination of cancer. This review summarizes several key regulators of the cell cycle in CSCs as well as attempts to define future challenges in this field, especially from the point of view of the application of our current understandings to the clinical medicine.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Takeishi
mesh_terms: D000818:Animals; D002453:Cell Cycle; D044783:F-Box Proteins / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D044783:F-Box Proteins; D016898:Interferon-alpha; D016179:Granulocyte Colony-Stimulating Factor