title: Lysosomal calcium regulates autophagy.
abstract: Recent evidence has indicated that the lysosome is able to act as a signaling organelle that senses nutrient availability and generates an adaptive response that is important for cellular homeostasis. We recently discovered another example of lysosomal signaling where lysosomal calcium release activates the master autophagy regulator TFEB via the phosphatase calcineurin.
authors.affiliation: a Telethon Institute of Genetics and Medicine (TIGEM) ; Pozzuoli, Naples , Italy.
authors.forename: Diego L
authors.initials: DL
authors.lastname: Medina
authors.forename: Andrea
authors.initials: A
authors.lastname: Ballabio
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology
chemical_list: D002118:Calcium
keywords: TFEB; TRPML1; autophagy; calcineurin; lysosomal calcium