title: Initial experience with therapeutic geometric modification of the carotid bulb for true resistant hypertension.
abstract: The contribution of carotid baroreceptor feedback in preventing or potentially contributing to the essential hypertensive cascade is poorly understood. It is clear the carotid sinus nerve action potentials are triggered by carotid bulb stretch rather than pressure and are only sustained during pulsatile increases in pressure. In addition, the carotid baroreceptor negative feedback is gradually extinguished in hypertension patients (a phenomenon known as "resetting"). We report a case of significant reduction in blood pressure in a patient with true resistant hypertension after change in the carotid bulb pulsatile strain patterns following the implant of an intravascular prosthesis.
authors.affiliation: Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
authors.forename: Najibullah
authors.initials: N
authors.lastname: Habib
authors.forename: Bakhtawar K
authors.initials: BK
authors.lastname: Mahmoodi
authors.forename: Willem Jan W
authors.initials: WJ
authors.lastname: Bos
authors.forename: Selma C
authors.initials: SC
authors.lastname: Tromp
authors.forename: Maarten J
authors.initials: MJ
authors.lastname: Suttorp
authors.forename: Mark C
authors.initials: MC
authors.lastname: Bates
authors.forename: Jan
authors.initials: J
authors.lastname: Van der Heyden
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D017704:Baroreflex; D001794:Blood Pressure / Q000187:drug effects*; D002346:Carotid Sinus / Q000000981:diagnostic imaging / Q000294:innervation / Q000601:surgery*; D004351:Drug Resistance; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D058542:Implantable Neurostimulators; D040542:Mechanotransduction, Cellular; D008875:Middle Aged; D011311:Pressoreceptors / Q000503:physiopathology*; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000295:instrumentation*; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents