title: NetworkPainter: dynamic intracellular pathway animation in Cytobank.
abstract: BACKGROUND
  High-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the data produced by these technologies is challenging. Visualization is needed to help researchers explore this data.
  
  
  RESULTS
  We developed a web-based software program, NetworkPainter, to enable researchers to analyze dynamic cytometry data in the context of pathway diagrams. NetworkPainter provides researchers a graphical interface to draw and "paint" pathway diagrams with experimental data, producing animated diagrams which display the activity of each network node at each time point.
  
  
  CONCLUSIONS
  NetworkPainter enables researchers to more fully explore multi-parameter, dynamical cytometry data.
authors.affiliation: Graduate Program in Biophysics, Stanford University, 443 Via Ortega, MC 4245, Stanford, CA, 94305, USA. jkarr@stanfordalumni.org.|Department of Genetics & Genomic Sciences, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, 10029, USA. jkarr@stanfordalumni.org.
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Karr
authors.affiliation: Department of Electrical Engineering, Stanford University, 279 Campus Drive West, MC 5329, Stanford, CA, 94305, USA. hguturu@stanford.edu.
authors.forename: Harendra
authors.initials: H
authors.lastname: Guturu
authors.affiliation: Department of Bioengineering, Stanford University, 443 Via Ortega, MC 4245, Stanford, CA, 94305, USA. edchen@alumni.stanford.edu.
authors.forename: Edward Y
authors.initials: EY
authors.lastname: Chen
authors.affiliation: Cytobank Inc, 821 West El Camino Real, Mountain View, CA, 94040, USA. stu@cytobank.org.
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Blair
authors.affiliation: Department of Medicine, Stanford University, 269 Campus Drive West, MC 5175, Stanford, CA, 94305, USA. jonathan.irish@vanderbilt.edu.|Department of Microbiology & Immunology, Stanford University, 269 Campus Drive West, MC 5175, Stanford, CA, 94305, USA. jonathan.irish@vanderbilt.edu.|Cytobank Inc, 821 West El Camino Real, Mountain View, CA, 94040, USA. jonathan.irish@vanderbilt.edu.|Department of Cancer Biology, Vanderbilt University, 740B Preston Building, 2220 Pierce Avenue, Nashville, TN, 37232, USA. jonathan.irish@vanderbilt.edu.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Irish
authors.affiliation: Graduate Program in Biomedical Informatics, Stanford University, 269 Campus Drive West, MC 5175, Stanford, CA, 94305, USA. nikesh@cytobank.org.|Cytobank Inc, 821 West El Camino Real, Mountain View, CA, 94040, USA. nikesh@cytobank.org.
authors.forename: Nikesh
authors.initials: N
authors.lastname: Kotecha
authors.affiliation: Department of Bioengineering, Stanford University, 443 Via Ortega, MC 4245, Stanford, CA, 94305, USA. mcovert@stanford.edu.
authors.forename: Markus W
authors.initials: MW
authors.lastname: Covert
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D003593:Cytoplasm / Q000378:metabolism; D003628:Database Management Systems; D016208:Databases, Factual; D005434:Flow Cytometry / Q000295:instrumentation* / Q000592:standards; D006801:Humans; D020407:Internet; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D015398:Signal Transduction; D012984:Software