title: [Significances of COX-2, p21, Ki-67 expression and HPV infection in nasal inverted papilloma].
abstract: OBJECTIVE
  To investigate the significance of expression of COX-2, p21, Ki67 and HPV in nasal inverted papilloma.
  
  
  METHODS
  Detecting COX-2, p21, Ki-67 in 30 cases of nasal inverted papilloma (NIP), 20 cases of nasal polyps (NP) and 10 cases of normal nasal mucosa (NM) by two step immunohistochemical method, and HPV virus by flow-through hybridization method.
  
  
  RESULTS
  The positive expression rate of COX-2 and Ki-67 in NIP, NP and NM group was decreased in turn, COX-2 had significant difference in the groups(χ2 = 30.00, P< 0. 05); the positive expression rate of Ki-67 had significant differences between NIP and NM group (χ2 = 8. 533, P<0. 05). The expression of COX-2 in NIP tissues was positively correlate with that of Ki-67 by using Spearman rank correlation analysis (r=0.78, P<0.05). Expression of p21 were not observed in NIP group. The positive rate of HPV was 26. 67% in 30 cases of NIP, all of HPV16 type.
  
  
  CONCLUSIONS
  COX-2, Ki-67 and HPV infection have certain correlation with the occurrence of NIP. The occurrence of NIP has relationship with inflammatory reaction mediated by COX-2. Ki-67 can well reflect the proliferation activity of tumor cells, and can be used to measure the proliferation rate of nasal inverted papilloma. The COX-2 and Ki-67 have a synergistic role in the pathogenesis of NIP. p21 has no significant relationship with the incidence of NIP. HPV infection is related to the pathogenesis of NIP, but not as a;major factor in the pathogenesis of NIP.
authors.forename: Xianying
authors.initials: X
authors.lastname: Meng
authors.forename: Xu
authors.initials: X
authors.lastname: Wu
authors.forename: Yibing
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D016022:Case-Control Studies; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000096:biosynthesis*; D051546:Cyclooxygenase 2 / Q000096:biosynthesis*; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D009297:Nasal Mucosa; D009298:Nasal Polyps; D009669:Nose Neoplasms / Q000235:genetics* / Q000821:virology; D018308:Papilloma, Inverted / Q000235:genetics* / Q000821:virology; D030361:Papillomavirus Infections
chemical_list: C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D019394:Ki-67 Antigen; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human