title: Antibiotic susceptibility of Acinetobacter species in intensive care unit in Montenegro.
abstract: The global increase in multidrug resistance of Acinetobacter has created widespread problems in the treatment of patients in intensive care units (ICUs). The aim of this study was to assess the current level of antimicrobial susceptibility of Acinetobacter species in ICU of Clinical Centre of Montenegro and determine their epidemiology. Antibiotic susceptibility was tested in 70 isolates of Acinetobacter collected from non-repeating samples taken from 40 patients. The first nine isolates were genotyped by repetitive sequence-based PCR (rep-PCR). Tigecycline was found to be the most active antimicrobial agent with 80.6% of susceptibility. All the isolates were multidrug resistant with fully resistance to cefalosporinas, piperacillin and piperacillin/tazobactam. More than half of them (58.5%) were probably extensively resistant. Seven out of nine examined strains were clonally related by rep-PCR. Our results showed extremely high rate of multidrug resistance (MDR) of Acinetobacter isolates and high percentage of its clonally spreading.
authors.affiliation: a Institute of Public Health , Podgorica , Montenegro.
authors.forename: Gordana
authors.initials: G
authors.lastname: Mijovic
authors.affiliation: b Clinical Center of Montenegro , Podgorica , Montenegro.
authors.forename: Ljubica
authors.initials: L
authors.lastname: Pejakov
authors.affiliation: a Institute of Public Health , Podgorica , Montenegro.
authors.forename: Danijela
authors.initials: D
authors.lastname: Vujosevic
mesh_terms: D000150:Acinetobacter / Q000187:drug effects* / Q000302:isolation & purification; D000151:Acinetobacter Infections / Q000453:epidemiology / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D006801:Humans; D007362:Intensive Care Units; D054548:Montenegro / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents
keywords: Acinetobacter; Intensive care unit; Multidrug resistance