title: Single nucleotide polymorphisms of the NF-κB and STAT3 signaling pathway genes predict lung cancer prognosis in a Chinese Han population.
abstract: Inflammation contributes to human carcinogenesis and cancer progression. This study selected and analyzed single nucleotide polymorphisms (SNPs) of the NF-κB and STAT3 signaling pathway genes for associations with prognosis in 1,165 lung cancer patients from a Chinese Han population. The data showed that eight SNPs (i.e., rs10836, rs3732131, rs3732133, rs4072391, rs2273650, rs1053023, rs3744483, and rs28372683) can be grouped into low-, medium-, and high-risk genotypes based on survival data. The median overall survival time (MST) of this cohort of patients was 24.6 months, whereas the MST of patients with low-risk genotypes reached 79.7 months; MST of patients with the medium-risk genotypes was 25.5 months, and those with high-risk genotypes was 22.7 months. Overall survival was statistically different for sex (P = 0.004), age (P = 0.010), histological types (P = 0.035), tumor stage (P < 0.001), tumor size (P < 0.001), surgery (P < 0.001), chemoradiotherapy (P = 0.007), and Karnofsky score (P < 0.001). Multivariate analysis and the data from the current study demonstrated that sex, tumor stage and size, surgery, chemoradiotherapy, and the aforementioned eight SNPs were all independent predictors for overall survival of lung cancer patients.
authors.affiliation: Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China.
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.affiliation: Department of Medical Record Management, Fujian Medical University Union Hospital, Fuzhou, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Prevention and Health Care, No.2 Hospital Xiamen, Xiamen, China.
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Li
authors.affiliation: Department of Public Health, Xiamen Center for Disease Control and Prevention, Xiamen, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ye
authors.affiliation: Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China.
authors.forename: Bao-chang
authors.initials: BC
authors.lastname: He
authors.affiliation: Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.affiliation: School Office, School of Nursing, Fujian Medical University, Fuzhou, China.
authors.forename: Xiao-qin
authors.initials: XQ
authors.lastname: Xu
authors.affiliation: Department of Prevention and Health Care, Fujian Medical University Union Hospital, Fuzhou, China.
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Zheng
authors.affiliation: Department of Chronic and Endemic Disease Control, Xiamen Center for Disease Control and Prevention, Xiamen, China.
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Luo
authors.affiliation: Department of Epidemiology, School of Public Health, Fujian Medical University, Fuzhou, China. Electronic address: x117x@163.com.
authors.forename: Lin
authors.initials: L
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D002681:China; D005260:Female; D006801:Humans; D007249:Inflammation / Q000235:genetics; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D050796:STAT3 Transcription Factor / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D016328:NF-kappa B; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human
keywords: NF-κB; STAT3; Single nucleotide polymorphism; lung cancer; prognosis