title: Whole-Body MR Imaging in the German National Cohort: Rationale, Design, and Technical Background.
abstract: OBJECTIVE
  To detail the rationale, design, and future perspective of implementing whole-body magnetic resonance (MR) imaging in the German National Cohort, a large multicentric population-based study.
  
  
  METHODS
  All institutional review boards approved the study, and informed consent is obtained before study enrollment. Participants are enrolled from a random sample of the general population at five dedicated imaging sites among 18 recruitment centers. MR imaging facilities are equipped with identical 3.0-T imager technology and use uniform MR protocols. Imager-specific hardware and software settings remained constant over the study period. On-site and centralized measures of image quality enable monitoring of completeness of the acquisitions and quality of each of the MR sequences. Certified radiologists read all MR imaging studies for presence of incidental findings according to predefined algorithms.
  
  
  RESULTS
  Over a 4-year period, six participants per day are examined at each center, totaling a final imaging cohort of approximately 30 000 participants. The MR imaging protocol is identical for each site and comprises a set of 12 native series to cover neurologic, cardiovascular, thoracoabdominal, and musculoskeletal imaging phenotypes totaling approximately 1 hour of imaging time. A dedicated analysis platform as part of a central imaging core incorporates a thin client-based integrative and modular data handling platform to enable multicentric off-site image reading for incidental findings. Scientific analysis will be pursued on a per-project hypothesis-driven basis.
  
  
  CONCLUSIONS
  Population-based whole-body MR imaging as part of the German National Cohort will serve to compile a comprehensive image repository, will provide insight into physiologic variants and subclinical disease burden, and has the potential to enable identification of novel imaging biomarkers of risk.
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Fabian
authors.initials: F
authors.lastname: Bamberg
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Sabine
authors.initials: S
authors.lastname: Weckbach
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Schlett
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Michael
authors.initials: M
authors.lastname: Forsting
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Susanne C
authors.initials: SC
authors.lastname: Ladd
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Karin Halina
authors.initials: KH
authors.lastname: Greiser
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Marc-André
authors.initials: MA
authors.lastname: Weber
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Jeanette
authors.initials: J
authors.lastname: Schulz-Menger
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Thoralf
authors.initials: T
authors.lastname: Niendorf
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Tobias
authors.initials: T
authors.lastname: Pischon
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Svenja
authors.initials: S
authors.lastname: Caspers
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Katrin
authors.initials: K
authors.lastname: Amunts
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Klaus
authors.initials: K
authors.lastname: Berger
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Robin
authors.initials: R
authors.lastname: Bülow
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Norbert
authors.initials: N
authors.lastname: Hosten
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Katrin
authors.initials: K
authors.lastname: Hegenscheid
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Thomas
authors.initials: T
authors.lastname: Kröncke
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Jakob
authors.initials: J
authors.lastname: Linseisen
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Matthias
authors.initials: M
authors.lastname: Günther
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Jochen G
authors.initials: JG
authors.lastname: Hirsch
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Alexander
authors.initials: A
authors.lastname: Köhn
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Thomas
authors.initials: T
authors.lastname: Hendel
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Heinz-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Börge
authors.initials: B
authors.lastname: Schmidt
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Jöckel
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hoffmann
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Maximilian F
authors.initials: MF
authors.lastname: Reiser
authors.affiliation: From the German National Cohort (GNC) Consortium, Central Executive Office of the German National Cohort, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany (F.B.); Department of Clinical Radiology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany (F.B., T.H., M.F.R.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany (H.U.K., S.W., C.L.S., M.A.W.); Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany (M.F., S.C.L.); Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (K.H.G., R.K.); Charité Campus Buch, ECRC Universitätsmedizin Berlin und HELIOS Klinik Berlin-Buch, Klinik für Kardiologie und Nephrologie, Berlin, Germany (J.S.); Berlin Ultrahigh Field Facility (BUFF), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany (T.N.); Epidemiology Research Group, Max-Delbrueck Center for Molecular Medicine (MDC), Berlin-Buch, Germany (T.P.); Institute of Neuroscience and Medicine (INM-1), Jülich Research Centre, Jülich, Germany (S.C., K.A.); C. and O. Vogt Institute for Brain Research, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (K.A.); JARA-BRAIN, Jülich-Aachen Research Alliance, Jülich, Germany (K.A.); Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany (K.B.); Department of Radiology and Neuroradiology, University Medicine Greifswald, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany (R.B., N.H., K.H.); Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Augsburg, Germany (T.K.); Helmholtz Zentrum München-German Research Center for Environmental Health, Munich, Germany (J.L., H.E.W.); Institute of Medical Infor
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
mesh_terms: D005858:Germany; D006801:Humans; D033162:Incidental Findings; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000592:standards; D012107:Research Design; D051598:Whole Body Imaging / Q000379:methods / Q000592:standards