title: Nanoscale Piezoelectric Properties of Self-Assembled Fmoc-FF Peptide Fibrous Networks.
abstract: Fibrous peptide networks, such as the structural framework of self-assembled fluorenylmethyloxycarbonyl diphenylalanine (Fmoc-FF) nanofibrils, have mechanical properties that could successfully mimic natural tissues, making them promising materials for tissue engineering scaffolds. These nanomaterials have been determined to exhibit shear piezoelectricity using piezoresponse force microscopy, as previously reported for FF nanotubes. Structural analyses of Fmoc-FF nanofibrils suggest that the observed piezoelectric response may result from the noncentrosymmetric nature of an underlying β-sheet topology. The observed piezoelectricity of Fmoc-FF fibrous networks is advantageous for a range of biomedical applications where electrical or mechanical stimuli are required.
authors.affiliation: †School of Physics, University College Dublin, Belfield, Dublin 4, Ireland.|‡Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Kate
authors.initials: K
authors.lastname: Ryan
authors.affiliation: §School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Jason
authors.initials: J
authors.lastname: Beirne
authors.affiliation: §School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Gareth
authors.initials: G
authors.lastname: Redmond
authors.affiliation: ‡Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Jason I
authors.initials: JI
authors.lastname: Kilpatrick
authors.affiliation: †School of Physics, University College Dublin, Belfield, Dublin 4, Ireland.|‡Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Jill
authors.initials: J
authors.lastname: Guyonnet
authors.affiliation: †School of Physics, University College Dublin, Belfield, Dublin 4, Ireland.|∥Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Nicolae-Viorel
authors.initials: NV
authors.lastname: Buchete
authors.affiliation: #Ural Federal University, Lenin Ave. 51, Ekaterinburg 620083, Russia.
authors.forename: Andrei L
authors.initials: AL
authors.lastname: Kholkin
authors.affiliation: †School of Physics, University College Dublin, Belfield, Dublin 4, Ireland.|‡Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Rodriguez
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D002942:Circular Dichroism; D004151:Dipeptides; D005449:Fluorenes / Q000737:chemistry*; D020100:Hydrogels; D018625:Microscopy, Atomic Force; D057139:Nanofibers / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001672:Biocompatible Materials; D004151:Dipeptides; D005449:Fluorenes; D020100:Hydrogels; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D010455:Peptides; C026650:phenylalanylphenylalanine; D010649:Phenylalanine
keywords: biomaterials; hydrogels; peptides; piezoelectricity; piezoresponse force microscopy