title: Influence of renovascular hypertension on the distribution of vasoactive intestinal peptide in the stomach and heart of rats.
abstract: Arterial hypertension is associated with serious dysfunction of the cardiovascular system and digestive system. Given the relevant role of vasoactive intestinal peptide (VIP) in the regulation of digestion process, control of blood pressure and heart rate as well as cardio- and gastro-protective character of the peptide, it appeared worthwhile to undertake the research aimed at immunohistochemical identification and evaluation of VIP-positive structures in the pylorus and heart of hypertensive rats. Up to now, this issue has not been investigated. The experimental model of hypertension in rats according to Goldblatt (two-kidney one clip model of hypertension) was used in the study. The experimental material (pylorus and heart) was collected in the sixth week of the study. VIP-containing structures were evaluated using immunohistochemical and morphometric methods. The analysis of the results showed a significant increase in the number of immunoreactive VIP structures and in the intensity of immunohistochemical staining in the stomach and in the heart of hypertensive rats. Our findings indicate that VIP is an important regulator of cardiovascular and digestive system in physiological and pathological conditions. However, to better understand the exact role of VIP in hypertension further studies need to be carried out.
authors.affiliation: Department of Histology and Cytophysiology, Medical University of Bialystok, 15-089 Białystok, Poland kasacka@umb.edu.pl.
authors.forename: Irena
authors.initials: I
authors.lastname: Kasacka
authors.affiliation: Department of Histology and Cytophysiology, Medical University of Bialystok, 15-089 Białystok, Poland.
authors.forename: Żaneta
authors.initials: Ż
authors.lastname: Piotrowska
authors.affiliation: Department of Dietetics and Food Assessment, Institute of Health Sciences, University of Natural Sciences and Humanities, 08-110 Siedlce, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Janiuk
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000378:metabolism*; D005786:Gene Expression Regulation; D006339:Heart Rate; D006978:Hypertension, Renovascular / Q000473:pathology*; D007150:Immunohistochemistry; D007249:Inflammation; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
chemical_list: D014660:Vasoactive Intestinal Peptide
keywords: Vasoactive intestinal peptide; heart; immunohistochemistry; rat; renovascular hypertension; stomach