title: The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease.
abstract: Alzheimer's disease (EOAD, LOAD), mild cognitive impairment (MCI), Parkinson's disease (PD) and healthy controls were included to determine the serum interleukin-1s (IL-1α, IL-1β), IL-6 and alpha-2-macroglobulin (α2M) levels using ELISA. IL-6 might be a significant contributor to the inflammatory response in LOAD. The MCI data indicate that IL-1s, α2M and BDNF are somehow related, and this relationship might allow MCI patients to be more similar to the healthy controls. A correlation analysis of multiple biomarkers in different neurodegenerative disorders might be more useful than determining the levels of a single cytokine in a single disorder.
authors.affiliation: Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: erdincdu@yahoo.com.
authors.forename: Erdinç
authors.initials: E
authors.lastname: Dursun
authors.affiliation: Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: duygugezenak@gmail.com.
authors.forename: Duygu
authors.initials: D
authors.lastname: Gezen-Ak
authors.affiliation: Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Haşmet
authors.initials: H
authors.lastname: Hanağası
authors.affiliation: Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Başar
authors.initials: B
authors.lastname: Bilgiç
authors.affiliation: Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ebba
authors.initials: E
authors.lastname: Lohmann
authors.affiliation: Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Sibel
authors.initials: S
authors.lastname: Ertan
authors.affiliation: Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: İrem L
authors.initials: İL
authors.lastname: Atasoy
authors.affiliation: Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Alaylıoğlu
authors.affiliation: Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ömür Selin
authors.initials: ÖS
authors.lastname: Araz
authors.affiliation: Department of Medical Pharmacology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Önal
authors.affiliation: Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Gündüz
authors.affiliation: Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Hülya
authors.initials: H
authors.lastname: Apaydın
authors.affiliation: Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Güneş
authors.initials: G
authors.lastname: Kızıltan
authors.affiliation: Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Turgut
authors.initials: T
authors.lastname: Ulutin
authors.affiliation: Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Gürvit
authors.affiliation: Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: drselmayilmazer@gmail.com.
authors.forename: Selma
authors.initials: S
authors.lastname: Yılmazer
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood; D060825:Cognitive Dysfunction / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation; D053582:Interleukin-1alpha / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000276:immunology; D000511:alpha-Macroglobulins / Q000032:analysis*
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; C508600:IL6 protein, human; D053582:Interleukin-1alpha; D053583:Interleukin-1beta; D015850:Interleukin-6; D000511:alpha-Macroglobulins; C579455:BDNF protein, human
keywords: Alpha-2 macroglobulin (α2-macroglobulin); Alzheimer's disease; Biomarker; Brain derived neurotrophic factor (BDNF); Heat shock protein 90 (Hsp90); Interleukin 1 alpha (IL-1α); Interleukin 1 beta (IL-1β); Interleukin 10 (IL-10); Interleukin 6 (IL-6); Mild cognitive impairment (MCI); Parkinson's disease (PD); Tumor necrosis factor alpha (TNFα)