title: Applying the ARRIVE Guidelines to an In Vivo Database.
abstract: The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were developed to address the lack of reproducibility in biomedical animal studies and improve the communication of research findings. While intended to guide the preparation of peer-reviewed manuscripts, the principles of transparent reporting are also fundamental for in vivo databases. Here, we describe the benefits and challenges of applying the guidelines for the International Mouse Phenotyping Consortium (IMPC), whose goal is to produce and phenotype 20,000 knockout mouse strains in a reproducible manner across ten research centres. In addition to ensuring the transparency and reproducibility of the IMPC, the solutions to the challenges of applying the ARRIVE guidelines in the context of IMPC will provide a resource to help guide similar initiatives in the future.
authors.affiliation: Mouse Informatics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
authors.forename: Natasha A
authors.initials: NA
authors.lastname: Karp
authors.affiliation: Samples, Phenotypes and Ontologies, European Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, United Kingdom.
authors.forename: Terry F
authors.initials: TF
authors.lastname: Meehan
authors.affiliation: Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.
authors.forename: Hugh
authors.initials: H
authors.lastname: Morgan
authors.affiliation: Samples, Phenotypes and Ontologies, European Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, United Kingdom.
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Mason
authors.affiliation: Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.
authors.forename: Andrew
authors.initials: A
authors.lastname: Blake
authors.affiliation: Samples, Phenotypes and Ontologies, European Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, United Kingdom.
authors.forename: Natalja
authors.initials: N
authors.lastname: Kurbatova
authors.affiliation: Mouse Informatics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
authors.forename: Damian
authors.initials: D
authors.lastname: Smedley
authors.affiliation: Mouse Informatics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
authors.forename: Julius
authors.initials: J
authors.lastname: Jacobsen
authors.affiliation: The Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom.
authors.forename: Richard F
authors.initials: RF
authors.lastname: Mott
authors.affiliation: Cellular Genetics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
authors.forename: Vivek
authors.initials: V
authors.lastname: Iyer
authors.affiliation: Cellular Genetics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: Matthews
authors.affiliation: Mouse Informatics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
authors.forename: David G
authors.initials: DG
authors.lastname: Melvin
authors.affiliation: Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.
authors.forename: Sara
authors.initials: S
authors.lastname: Wells
authors.affiliation: Toronto Centre for Phenogenomics, Mount Sinai Hospital, Toronto, Canada.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Flenniken
authors.affiliation: BioResource Center, RIKEN, Tsukuba, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Masuya
authors.affiliation: BioResource Center, RIKEN, Tsukuba, Japan.
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Wakana
authors.affiliation: Mouse Genetics Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
authors.forename: Jacqueline K
authors.initials: JK
authors.lastname: White
authors.affiliation: Mouse Biology Program, University of California Davis, Davis, California, United States of America.
authors.forename: K C Kent
authors.initials: KC
authors.lastname: Lloyd
authors.affiliation: Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Corey L
authors.initials: CL
authors.lastname: Reynolds
authors.affiliation: Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America.
authors.forename: Richard
authors.initials: R
authors.lastname: Paylor
authors.affiliation: Genetics, Children's Hospital Oakland Research Institute, Oakland, California, United States of America.
authors.forename: David B
authors.initials: DB
authors.lastname: West
authors.affiliation: Genetics, The Jackson Laboratory, Bar Habour, Maine, United States of America.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Svenson
authors.affiliation: Genetics, The Jackson Laboratory, Bar Habour, Maine, United States of America.
authors.forename: Elissa J
authors.initials: EJ
authors.lastname: Chesler
authors.affiliation: German Mouse Clinic-Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany; Experimental Genetics-Center of Life and Food, Technische Universität München, Freising-Weihenstephan, Germany.
authors.forename: Martin Hrabě
authors.initials: MH
authors.lastname: de Angelis
authors.affiliation: Monterotondo Mouse Clinic, CNR Institute of Cell Biology and Neurobiology, Monterotondo, Scalo, Italy.
authors.forename: Glauco P
authors.initials: GP
authors.lastname: Tocchini-Valentini
authors.affiliation: PHENOMIN, Centre National de la Recherche Scientifique, Illkirch, France; Institut Clinique de la Souris, Université de Strasbourg, Illkirch, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Illkirch, France.
authors.forename: Tania
authors.initials: T
authors.lastname: Sorg
authors.affiliation: PHENOMIN, Centre National de la Recherche Scientifique, Illkirch, France; Institut Clinique de la Souris, Université de Strasbourg, Illkirch, France; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964, Illkirch, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Herault
authors.affiliation: Samples, Phenotypes and Ontologies, European Molecular Biology Laboratory-European Bioinformatics Institute, Cambridge, United Kingdom.
authors.forename: Helen
authors.initials: H
authors.lastname: Parkinson
authors.affiliation: Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Mallon
authors.affiliation: Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom.
authors.forename: Steve D M
authors.initials: SD
authors.lastname: Brown
mesh_terms: D032761:Animal Experimentation / Q000592:standards*; D000818:Animals; D019992:Databases as Topic; D017408:Guidelines as Topic; D051379:Mice; D010641:Phenotype