title: Nodulisporiviridins A-H, Bioactive Viridins from Nodulisporium sp.
abstract: Eight new viridins, nodulisporiviridins A-H (1-8), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (No. 65-17-2-1) that was fermented with potato-dextrose broth. The structures were determined using spectroscopic and X-ray crystallographic analysis. Nodulisporiviridins A-D (1-4) are unique viridins with an opened ring A. The Aβ42 aggregation inhibitory activities of 1-8 were evaluated using a thioflavin T (ThT) assay with epigallocatechin gallate (EGCG) as the positive control (EGCG IC50 of 0.5 μM). Nodulisporiviridin G (7) displayed potent inhibitory activity with an IC50 value of 1.2 μM, and the preliminary trend of activity of these viridins as Aβ42 aggregation inhibitors was proposed. The short-term memory assay on an Aβ transgenic drosophila model of Alzheimer's disease showed that all eight compounds improved the short-term memory capacity, with potencies close to that of the positive control (memantine).
authors.affiliation: †Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: †Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.affiliation: †Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Feng
authors.affiliation: †Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: †Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: He
authors.affiliation: †Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Li
authors.affiliation: ‡State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: ‡State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, People's Republic of China.
authors.forename: Wen-Xia
authors.initials: WX
authors.lastname: Zhou
authors.affiliation: §State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Liang-Dong
authors.initials: LD
authors.lastname: Guo
authors.affiliation: ⊥Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, People's Republic of China.
authors.forename: Yi-Zhi
authors.initials: YZ
authors.lastname: Zheng
authors.affiliation: †Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.affiliation: †Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000187:drug effects / Q000378:metabolism; D000736:Androstenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D001430:Bacteriocins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives; D002681:China; D018360:Crystallography, X-Ray; D004195:Disease Models, Animal; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010446:Peptide Fragments; D013098:Xylariales / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D000736:Androstenes; D001430:Bacteriocins; D010446:Peptide Fragments; D002392:Catechin; C045651:epigallocatechin gallate; C012097:viridin