title: The emerging role of hypoxia-inducible factor-2 involved in chemo/radioresistance in solid tumors.
abstract: The hypoxic condition is a common feature that negatively impacts the efficacy of radio- and chemotherapy in solid tumors. Hypoxia-inducible factors (HIF-1, 2, 3) predominantly regulate the adaptation to hypoxia at the cellular or organismal level. HIF-2 is one of the three known alpha subunits of HIF transcription factors. Previous studies have shown that HIF-1 is associated with chemotherapy failure. Accumulating evidence in recent years suggests that HIF-2 also contributes to chemo/radioresistance in solid tumors. Despite sharing similar structures, HIF-1α and HIF-2α had highly divergent and even opposing roles in solid tumors under hypoxic conditions. Recent studies have also implied that HIF-2α had a role in chemo/radioresistance through different mechanisms, at least partly, compared to HIF-1α. The present paper summarizes the function of HIF-2 in chemo/radioresistance in solid tumors as well as some of its novel mechanisms that contributed to this pathological process.
authors.affiliation: Department of Medical Oncology, Cancer Institute & Hospital, Peking Union Medical College, Beijing, China; Chinese Academy of Medical Science, Beijing, China; Affiliated Hospital of Qinghai University, Xining, China.
authors.forename: Jiuda
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Medical Oncology, Cancer Institute & Hospital, Peking Union Medical College, Beijing, China; Chinese Academy of Medical Science, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Du
authors.affiliation: Department of Medical Oncology, Cancer Institute & Hospital, Peking Union Medical College, Beijing, China; Chinese Academy of Medical Science, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Affiliated Hospital of Qinghai University, Xining, China.
authors.forename: Guoshuang
authors.initials: G
authors.lastname: Shen
authors.affiliation: Affiliated Hospital of Qinghai University, Xining, China.
authors.forename: Fangchao
authors.initials: F
authors.lastname: Zheng
authors.affiliation: Department of Medical Oncology, Cancer Institute & Hospital, Peking Union Medical College, Beijing, China; Chinese Academy of Medical Science, Beijing, China. Electronic address: bhxu@hotmail.com.
authors.forename: Binghe
authors.initials: B
authors.lastname: Xu
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins; D015687:Cell Hypoxia / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D000099162:Endothelial PAS Domain-Containing Protein 1
keywords: Cancer; Chemo/radioresistance; HIF-2; Hypoxia