title: Iridoid constituents from the male flower of Eucommia ulmoides and their promotion proliferation on ESF-1.
abstract: Four new iridoids (1, 2, 12, and 13), together with nine known iridoids (3-11), were isolated from the male flowers of Eucommia ulmoides Oliver and were characterized as 3β-methoxyartselawnin C (1), 6β-hydroxyl-1β,3β-dimethoxyartsclaenin III (2), 3,4-dihydro-3β-ethoxyasperuloside (12) and 3,4-dihydro-3β-ethoxydesacetylasperuloside (13) by extensive analyses of their 1D and 2D NMR spectroscopy and mass spectra. All of the isolated compounds were assayed for the promoting proliferation of skin fibroblasts cell (ESF-1) and compounds 4 and 7 (5 μM) significantly stimulated the proliferation of ESF-1 cells.
authors.affiliation: a College of Pharmacy, Liaoning University of Traditional Chinese Medicine , Dalian 116600 , China.
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Ding
authors.affiliation: b Henan Provincial laboratory of Eucommia ulmoides Cultivation and Utilization, Henan University , Kaifeng 475001 , China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.affiliation: b Henan Provincial laboratory of Eucommia ulmoides Cultivation and Utilization, Henan University , Kaifeng 475001 , China.
authors.forename: Huan
authors.initials: H
authors.lastname: Zhang
authors.affiliation: c College of Pharmacy, Chungnam National University , Daejeon 305-764 , Republic of Korea.
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Kim
authors.affiliation: a College of Pharmacy, Liaoning University of Traditional Chinese Medicine , Dalian 116600 , China.
authors.forename: De-Qiang
authors.initials: DQ
authors.lastname: Dou
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031283:Eucommiaceae / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D039823:Iridoids; D010936:Plant Extracts
keywords: ESF-1; Eucommia ulmoides; iridoids; promotion proliferation