title: An IR Navigation System for Pleural PDT.
abstract: Pleural photodynamic therapy (PDT) has been used as an adjuvant treatment with lung-sparing surgical treatment for malignant pleural mesothelioma (MPM). In the current pleural PDT protocol, a moving fiber-based point source is used to deliver the light. The light fluences at multiple locations are monitored by several isotropic detectors placed in the pleural cavity. To improve the delivery of light fluence uniformity, an infrared (IR) navigation system is used to track the motion of the light source in real-time at a rate of 20 - 60 Hz. A treatment planning system uses the laser source positions obtained from the IR camera to calculate light fluence distribution to monitor the light fluence uniformity on the surface of the pleural cavity. A novel reconstruction algorithm is used to determine the pleural cavity surface contour. A dual-correction method is used to match the calculated fluences at detector locations to the detector readings. Preliminary data from a phantom shows superior light uniformity using this method. Light fluence uniformity from patient treatments is also shown with and without the correction method.
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Zhu
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Xing
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Michele M
authors.initials: MM
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Jarod C
authors.initials: JC
authors.lastname: Finlay
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Andreea
authors.initials: A
authors.lastname: Dimofte
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Carmen
authors.initials: C
authors.lastname: Rodriguez
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Charles B
authors.initials: CB
authors.lastname: Simone
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Friedberg
authors.affiliation: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Cengel
keywords: Infrared camera; PDT; Pleural; navigation system