title: Association between dietary phytoestrogen intake and bone mineral density varied with estrogen receptor alpha gene polymorphisms in southern Chinese postmenopausal women.
abstract: BACKGROUND
  several studies have investigated the relationship between the estrogen receptor (ER) gene polymorphisms and the efficacy of estrogen replacement therapy in postmenopausal osteoporosis. However, the association of ER polymorphisms with the effects of dietary phytoestrogens on bone metabolism has not yet been reported. This study explores the possibility that ER alpha subtype (ERα) gene polymorphisms are involved in the effects of dietary phytoestrogens on bone mineral density (BMD) in postmenopausal women.
  
  
  METHODS
  a total of 301 postmenopausal southern Chinese women were enrolled. Dietary phytoestrogen intake was evaluated using a food frequency questionnaire. ERα polymorphisms were examined with restriction fragment length polymorphism at the polymorphic PvuII and XbaI sites within intron 1. Dual-energy X-ray absorptiometry scans were performed to determine the BMD of the lumbar spine and hip.
  
  
  RESULTS
  the positive association of the lumbar spine BMD with dietary phytoestrogen intake was maintained only in groups with pp or xx genotypes (p < 0.05) and disappeared in groups with other genotypes. A positive association of the hip BMD with dietary phytoestrogen intake was observed only in the xx genotype group (p < 0.05).
  
  
  CONCLUSIONS
  the association of the dietary phytoestrogen intake and BMD in southern Chinese postmenopausal women varied with ERα gene polymorphisms.
authors.affiliation: State Key Laboratory of Food Science and Technology, Medical School, Nanchang University, Bayi Road 461, Nanchang, Jiangxi Province, P. R. China. weijiepeng@126.com.
authors.forename: Dan
authors.initials: D
authors.lastname: Luo
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Liu
authors.forename: Yin
authors.initials: Y
authors.lastname: Zhou
authors.forename: Zongwei
authors.initials: Z
authors.lastname: Chen
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: Qunying
authors.initials: Q
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.forename: Haibin
authors.initials: H
authors.lastname: Kuang
authors.forename: Qiren
authors.initials: Q
authors.lastname: Huang
authors.forename: Ming
authors.initials: M
authors.lastname: He
authors.forename: Weijie
authors.initials: W
authors.lastname: Peng
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000483:Alleles; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002681:China; D003430:Cross-Sectional Studies; D004032:Diet / Q000009:adverse effects; D047628:Estrogen Receptor alpha / Q000235:genetics* / Q000378:metabolism; D005260:Female; D056726:Genetic Association Studies; D006615:Hip; D006801:Humans; D007438:Introns; D008875:Middle Aged; D009749:Nutrition Surveys; D015663:Osteoporosis, Postmenopausal / Q000000981:diagnostic imaging / Q000209:etiology / Q000235:genetics* / Q000517:prevention & control; D048789:Phytoestrogens / Q000008:administration & dosage / Q000627:therapeutic use*; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D050071:Bone Density Conservation Agents; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D048789:Phytoestrogens