title: Epigenetic changes in neurology: DNA methylation in multiple sclerosis.
abstract: BACKGROUND
  Epigenetics is defined as the study of the mechanisms that regulate gene expression without altering the underlying DNA sequence. The best known is DNA methylation. Multiple Sclerosis (MS) is a disease with no entirely known etiology, in which it is stated that the involvement of environmental factors on people with a genetic predisposition, may be key to the development of the disease. It is at this intersection between genetic predisposition and environmental factors where DNA methylation may play a pathogenic role.
  
  
  METHODS
  A literature review of the effects of environmental risk factors for the development of MS can have on the different epigenetic mechanisms as well as the implication that such changes have on the development of the disease.
  
  
  CONCLUSIONS
  Knowledge of epigenetic modifications involved in the pathogenesis of MS, opens a new avenue of research for identification of potential biomarkers, as well as finding new therapeutic targets.
authors.affiliation: Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España.
authors.forename: M
authors.initials: M
authors.lastname: Iridoy Zulet
authors.affiliation: Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España; Navarrabiomed-Fundación Miguel Servet, Pamplona, Navarra, España.
authors.forename: L
authors.initials: L
authors.lastname: Pulido Fontes
authors.affiliation: Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España.
authors.forename: T
authors.initials: T
authors.lastname: Ayuso Blanco
authors.affiliation: Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España.
authors.forename: F
authors.initials: F
authors.lastname: Lacruz Bescos
authors.affiliation: Servicio de Neurología, Complejo Hospitalario de Navarra, Pamplona, Navarra, España; Navarrabiomed-Fundación Miguel Servet, Pamplona, Navarra, España. Electronic address: tmendioi@navarra.es.
authors.forename: M
authors.initials: M
authors.lastname: Mendioroz Iriarte
mesh_terms: D019175:DNA Methylation / Q000235:genetics*; D004777:Environment; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics* / Q000503:physiopathology; D009462:Neurology; D012307:Risk Factors; D012907:Smoking; D014808:Vitamin D Deficiency
keywords: D vitamin; DNA methylation; Epigenetics; Epigenética; Epstein Barr virus.; Esclerosis múltiple; Metilación del ADN; Multiple Sclerosis; Smoking; Tabaco; Virus Epstein Barr; Vitamina D