title: Acute hemodynamic effects of nebulized iloprost via the I-neb Adaptive Aerosol Delivery system in pulmonary hypertension.
abstract: Inhaled iloprost has proven to be an effective therapy in patients with pulmonary hypertension (PH). However, the acute hemodynamic effect of nebulized iloprost delivered via the I-neb Adaptive Aerosol Delivery (AAD) system remains unclear and needs to be assessed. In this study, 126 patients with PH were classified according to current guidelines (59, 34, 29, and 4 patients in groups 1/1', 3, 4, and 5, respectively; 20 patients had idiopathic pulmonary arterial hypertension [iPAH]), were randomly assigned to inhale iloprost 2.5 [Formula: see text]g (n = 67) or 5.0 [Formula: see text]g (n = 59) via the I-neb AAD system, and were assessed by right heart catheterization. In seven patients with iPAH, iloprost plasma levels were measured. The two iloprost doses caused decreases from baseline in pulmonary vascular resistance (PVR; 2.5 [Formula: see text]g: -14.7%; 5.0 [Formula: see text]g: -15.6%) and mean pulmonary arterial pressure (mPAP; 2.5 [Formula: see text]g: -11.0%; 5.0 [Formula: see text]g: -10.1%) while cardiac index (CI) increased (2.5 [Formula: see text]g: +6.5%; 5.0 [Formula: see text]g: +6.4%). The subset with iPAH also showed decreases from baseline in PVR and mPAP and an increase in CI. Peak iloprost plasma levels showed no significant difference after inhalation of 2.5 [Formula: see text]g or 5.0 [Formula: see text]g iloprost (95.5 pg/mL vs. 73.0 pg/mL; P = 0.06). In summary, nebulized iloprost delivered via the I-neb AAD system reduced mPAP and PVR and increased CI from baseline in a heterogeneous group of patients with PH and in the subset with iPAH. In patients with iPAH, inhalation of 2.5 [Formula: see text]g or 5.0 [Formula: see text]g iloprost resulted in broadly similar peak iloprost plasma levels.
authors.affiliation: Department of Pneumology, Kerckhoff Heart and Thoracic Center, Bad Nauheim, Germany ; Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center, Germany, and German Center for Lung Research.
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Richter
authors.affiliation: Department of Pneumology, Kerckhoff Heart and Thoracic Center, Bad Nauheim, Germany ; Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center, Germany, and German Center for Lung Research.
authors.forename: Hossein A
authors.initials: HA
authors.lastname: Ghofrani
authors.affiliation: Department of Pneumology, Kerckhoff Heart and Thoracic Center, Bad Nauheim, Germany ; Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center, Germany, and German Center for Lung Research ; Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Voswinckel
authors.affiliation: Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center, Germany, and German Center for Lung Research ; Department of Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.
authors.forename: Werner
authors.initials: W
authors.lastname: Seeger
authors.affiliation: Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center, Germany, and German Center for Lung Research.
authors.forename: Richard
authors.initials: R
authors.lastname: Schulz
authors.affiliation: Department of Pneumology, Asklepios Hospital, Munich-Gauting, Germany, and German Center for Lung Research.
authors.forename: Frank
authors.initials: F
authors.lastname: Reichenberger
authors.affiliation: Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center, Germany, and German Center for Lung Research.
authors.forename: Henning
authors.initials: H
authors.lastname: Gall
keywords: I-neb Adaptive Aerosol Delivery system; inhaled iloprost; pulmonary arterial hypertension