title: Reversible hypopituitarism with pituitary tuberculoma.
abstract: A 50-year-old woman presented with a headache and nausea. A sellar and suprasellar mass was detected on MRI; the tumor was heterogeneously enhanced with gadolinium, and the pituitary stalk was slightly thickened. Laboratory tests revealed severe growth hormone, luteinizing hormone, follicle-stimulating hormone and thyroid-stimulating hormone deficiencies. A pathological examination of the tumor showed scattered granulomas with central necrosis and Langhans giant cells. Tuberculin skin and QuantiFERON TB-Gold tests (QFT-2G) were positive. Accordingly, we diagnosed the patient with pituitary tuberculoma presenting with pituitary dysfunction. Following treatment with antituberculous drugs, the pituitary hormone function normalized and the pituitary tuberculoma disappeared.
authors.affiliation: Department of Internal Medicine (I), Osaka Medical College, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Tanimoto
authors.forename: Ayumi
authors.initials: A
authors.lastname: Imbe
authors.forename: Kanako
authors.initials: K
authors.lastname: Shishikura
authors.forename: Hisashi
authors.initials: H
authors.lastname: Imbe
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hiraiwa
authors.forename: Tomo
authors.initials: T
authors.lastname: Miyata
authors.forename: Naokado
authors.initials: N
authors.lastname: Ikeda
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kuroiwa
authors.forename: Jungo
authors.initials: J
authors.lastname: Terasaki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Hanafusa
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000502:physiology; D006801:Humans; D007018:Hypopituitarism / Q000209:etiology*; D007986:Luteinizing Hormone / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010900:Pituitary Diseases / Q000150:complications* / Q000473:pathology*; D010902:Pituitary Gland / Q000473:pathology; D014375:Tuberculoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000995:Antitubercular Agents; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone