title: The efficacy of a tissue-engineered xenograft in conjunction with sodium hyaluronate carrier in maxillary sinus augmentation: a clinical study.
abstract: PepGen P-15 Putty comprises anorganic bovine bone matrix (ABM) coupled with a synthetic cell-binding peptide, suspended in a sodium hyaluronate carrier. The P-15 portion exhibits a similar structure and properties to the cell-binding region of type I collagen. This study was performed to evaluate ABM/P-15 putty as the sole graft in sinus augmentation. Ten patients for whom both a sinus augmentation and two implants were indicated in the posterior maxilla were enrolled. Bone cores were harvested at 8 and 16 weeks, followed by placement of one implant at 8 weeks and the second at 16 weeks. Twenty collected bone cores were evaluated histologically and by micro-computed tomography. Results showed a significant increase (P<0.05) in bone mineral density at 8 weeks (0.70±0.13g/cm(3)) and 16 weeks (0.97±0.08g/cm(3)) in the graft compared to native (control) bone (0.04±0.02g/cm(3)). There was no significant difference (P>0.05) in the percentage bone volume at the two time intervals (PBV 21.14±4.56 at 8 weeks and 26.33±5.60 at 16 weeks). The average increase in bone height at 16 weeks was 10.55±0.53mm. It is concluded that PepGen P-15 Putty is capable of conducting and accelerating new bone formation and can successfully support dental implants.
authors.affiliation: Oral and Maxillofacial Surgery, College of Dentistry, The Ohio State University, OH, USA. Electronic address: emam.4@osu.edu.
authors.forename: H A
authors.initials: HA
authors.lastname: Emam
authors.affiliation: Oral and Maxillofacial Surgery, Cairo University, Cairo, Egypt.
authors.forename: G
authors.initials: G
authors.lastname: Behiri
authors.affiliation: Private Practice, IMMPRO Dental (Implant-Prosthodontics), Cairo, Egypt.
authors.forename: M
authors.initials: M
authors.lastname: El-Alaily
authors.affiliation: Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University, GA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Sharawy
mesh_terms: D000328:Adult; D001706:Biopsy; D018786:Bone Substitutes / Q000494:pharmacology*; D005260:Female; D064593:Heterografts; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology*; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011862:Radiography, Panoramic; D059546:Sinus Floor Augmentation / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes; C403137:PepGen P-15; D006820:Hyaluronic Acid
keywords: PepGen P-15; bone graft; sinus augmentation