title: A CRISPR Connection between Chromatin Topology and Genetic Disorders.
abstract: Structural variations are common in the human genome, but their contributions to human diseases have been hard to define. Lupiáñez et al. demonstrate that some structural variants can interrupt chromatin topology, resulting in ectopic enhancer-promoter interactions, altered spatiotemporal gene expression patterns, and developmental disorders.
authors.affiliation: Ludwig Institute for Cancer Research, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653. Electronic address: biren@ucsd.edu.
authors.forename: Bing
authors.initials: B
authors.lastname: Ren
authors.affiliation: Ludwig Institute for Cancer Research, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653.
authors.forename: Jesse R
authors.initials: JR
authors.lastname: Dixon
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D006801:Humans