title: Smart Albumin-Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation.
abstract: Smart cyanine-grafted gadolinium oxide nanocrystals (Cy-GdNCs) obtained by albumin-based biomineralization are shown to be theranostic nanocomposites, with promising properties for trimodal near-infrared fluorescence/photoacoustics/magnetic-resonance imaging-guided photothermal tumor ablation.
authors.affiliation: School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
authors.forename: Hengte
authors.initials: H
authors.lastname: Ke
authors.affiliation: Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Zhu
authors.affiliation: School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.
authors.forename: Yangyun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Radiology Department, Second Affiliated Hospital, Soochow University, Suzhou, 215004, China.
authors.forename: Junxin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Radiology Department, Second Affiliated Hospital, Soochow University, Suzhou, 215004, China.
authors.forename: Junkang
authors.initials: J
authors.lastname: Shen
authors.affiliation: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
authors.forename: Chunying
authors.initials: C
authors.lastname: Chen
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: School of Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, School of Radiation Medicine and Protection, Soochow University, Suzhou, 215123, China.|Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, Jiangsu, China.
authors.forename: Huabing
authors.initials: H
authors.lastname: Chen
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D005682:Gadolinium / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry; D008325:Mammary Neoplasms, Experimental / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008903:Minerals / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D064847:Multimodal Imaging / Q000379:methods*; D053761:Nanocomposites / Q000737:chemistry* / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry; D010789:Phototherapy; D011422:Propionates / Q000737:chemistry; D011487:Protein Conformation; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism*; D000068936:Theranostic Nanomedicine
chemical_list: C000604523:Cypate; D007211:Indoles; D008903:Minerals; D011422:Propionates; D012710:Serum Albumin, Bovine; C030581:gadolinium oxide; D005682:Gadolinium
keywords: biomineralization; multimodal imaging; nanocomposites; photothermal therapies; tumor ablations