title: Enantioselective Synthesis of β-Arylamines via Chiral Phosphoric Acid-Catalyzed Asymmetric Reductive Amination.
abstract: A new method for the synthesis of chiral β-aryl amines via chiral phosphoric acid-catalyzed enantioselective reductive amination of benzyl methyl ketone derivatives with Hantzsch ester was developed. Various chiral β-aryl amines were obtained in high yields and with good to high enantioselectivities. This transformation is applicable to gram-scale reactions, and the catalyst loading can be reduced to 1 mol % without sacrificing any catalytic efficacy. Furthermore, the resulting β-aryl amine was successfully converted into a tetrahydroisoquinoline compound without any loss of enantioselectivity.
authors.affiliation: Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136701, Republic of Korea.
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136701, Republic of Korea.
authors.forename: Chun-Young
authors.initials: CY
authors.lastname: Lee
authors.affiliation: Department of Chemistry, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 136701, Republic of Korea.
authors.forename: Cheol-Hong
authors.initials: CH
authors.lastname: Cheon