title: The effect of Hop (Humulus lupulus L.) on early menopausal symptoms and hot flashes: A randomized placebo-controlled trial.
abstract: OBJECTIVE
  This study aimed to evaluate the efficacy of Hop on early menopausal symptoms and hot flashes.
  
  
  METHODS
  In this randomized controlled trial, 120 women were randomly allocated into two groups, receiving the Hop or placebo tablets for 12 weeks. Early menopausal symptoms were assessed using Greene scale and hot flashes were recorded in a diary before, and 4, 8 and 12 weeks after intervention.
  
  
  RESULTS
  The mean Greene score was significantly lower in the Hop group than the placebo group at the end of weeks 4 (adjusted difference: -10.0, 95% confidence interval: -11.1--8.9), 8 (-18.6, -20.1--17.1) and 12 (-23.4, -25.1--21.6). The number of hot flashes was significantly lower in the Hop group than the control group during the weeks 4 (-8.4, -9.8--7.1), 8 (-17.1, -14.9--19.3) and 12 (-23.8, -21.1--26.4).
  
  
  CONCLUSIONS
  Hop effectively reduced the early menopausal symptoms.
  
  
  BACKGROUND
  This study was approved (code 91209) by the Ethic Committee of Tabriz university of Medical Sciences and registered at the Iranian registry of clinical trials, with IRCT 2013010110324N7 on April 2013.
authors.affiliation: Faculty of Nursing & Midwifery, Tabriz University of Medical Sciences, Student Research Committee Sciences, Iran.
authors.forename: Vida
authors.initials: V
authors.lastname: Aghamiri
authors.affiliation: Midwifery Department, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: mirghafourvandm@tbzmed.ac.ir.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Mirghafourvand
authors.affiliation: Social Determinants of Health (SDH) Research Center, Midwifery Department, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Sakineh
authors.initials: S
authors.lastname: Mohammad-Alizadeh-Charandabi
authors.affiliation: Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Nazemiyeh
mesh_terms: D000328:Adult; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D027582:Humulus / Q000737:chemistry*; D008593:Menopause; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts
keywords: Early menopausal symptoms; Hop (Humulus lupulus L.); Menopause; Randomized clinical trial