title: Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects d-galactosamin/lipopolysacchride-induced liver injury in rats.
abstract: Isofuranodiene is a natural sesquiterpene rich occurring in Smyrnium olusatrum, a forgotten culinary herb which was marginalised after the domestication of the improved form of celery. Our recent data showed that isofuranodiene inhibited the proliferation and induced apoptosis in cancer cells. In this study, we investigated its protective effect on d-galactosamine/lipopolysacchride (GalN/LPS)-induced liver injury in SD rats. Oral administration of isofuranodiene (20 and 50 mg/kg) dramatically inhibited GalN/LPS-induced serum elevation of aspartate aminotransferase, alanine aminotransferase and malondialdehyde levels, and significantly ameliorated liver injury as evidenced by the histological improvement in H&E staining. Furthermore, isofuranodiene treatment significantly inhibited GalN/LPS-induced mRNA expression of IL-1β, IL-6 and inducible nitric oxide synthase in liver tissues. The results from this study showed that isofuranodiene protects GalN/LPS-induced liver injury in SD rats and suggested that it may be a potential functional food ingredient for the prevention and treatment of liver diseases.
authors.affiliation: a Key Lab for Pharmacology of Ministry of Education, Department of Pharmacology , Zunyi Medical College , Zunyi , P.R. China.
authors.forename: Wenping
authors.initials: W
authors.lastname: Li
authors.affiliation: a Key Lab for Pharmacology of Ministry of Education, Department of Pharmacology , Zunyi Medical College , Zunyi , P.R. China.
authors.forename: Jingshan
authors.initials: J
authors.lastname: Shi
authors.affiliation: b School of Science and Technology, University of Camerino , Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Papa
authors.affiliation: c School of Pharmacy, University of Camerino , Camerino , Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Maggi
authors.affiliation: a Key Lab for Pharmacology of Ministry of Education, Department of Pharmacology , Zunyi Medical College , Zunyi , P.R. China.|d State Key Laboratory of Quality Research in Chinese Medicine , Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade , Taipa , Macau , P.R. China.
authors.forename: Xiuping
authors.initials: X
authors.lastname: Chen
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D018556:Crops, Agricultural / Q000737:chemistry; D005663:Furans / Q000494:pharmacology*; D005688:Galactosamine / Q000009:adverse effects; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008070:Lipopolysaccharides; D008107:Liver Diseases / Q000188:drug therapy; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005663:Furans; C000594089:IL1B protein, rat; D053583:Interleukin-1beta; D015850:Interleukin-6; D008070:Lipopolysaccharides; D020011:Protective Agents; D008315:Malondialdehyde; C017897:isofuranodiene; D005688:Galactosamine; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
keywords: galactosamine/lipopolysaccharide; hepatoprotective; isofuranodiene; rats