title: Validation of the association of TCF7L2 and SLC30A8 gene polymorphisms with post-transplant diabetes mellitus in Asian Indian population.
abstract: The rs7903146 and rs13266634 polymorphisms in the TCF7L2 and SLC30A8 genes, respectively, have been reported to be associated with type 2 diabetes. However, little is known about the association of these polymorphisms with post-transplant diabetes mellitus (PTDM). To study this linkage, we determined a distribution of allele and genotype frequencies in Asian Indians. 42 PTDM and 98 non-PTDM subjects were recruited. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to detect for rs7903146 and rs13266634 polymorphisms. The clinical details and statistical analysis for PTDM and non-PTDM subjects were recorded. Our results observed higher frequencies of the minor alleles in rs7903146 and rs13266634 polymorphisms in the PTDM group compared to the non-PTDM subjects. The allele frequencies also found to be significantly associated with PTDM (rs7903146: T vs C: OR-2.6; (95%CI: 1.2-5.6); p = 0.01; rs13266634: T vs C: OR-2.0; (95%CI: 1.1-3.4); p = 0.01). These findings suggest that rs7903146 and rs13266634 polymorphisms are associated with PTDM in the Asian Indian population despite a relatively small study group.
authors.affiliation: Department of Genetics and Molecular medicine, Kamineni Hospitals, Hyderabad, India; ; Department of Genetics, Vasavi Medical and Research Centre, Khairathabad, Hyderabad, India; ; Department of Genetics and Biotechnology, Osmania University, Tarnaka, Hyderabad, India;
authors.forename: IImran Ali
authors.initials: IA
authors.lastname: Khan
authors.affiliation: Department of Genetics and Biotechnology, Osmania University, Tarnaka, Hyderabad, India;
authors.forename: Parveen
authors.initials: P
authors.lastname: Jahan
authors.affiliation: Department of Genetics and Molecular medicine, Kamineni Hospitals, Hyderabad, India; ; Department of Genetics, Vasavi Medical and Research Centre, Khairathabad, Hyderabad, India;
authors.forename: Qurratulain
authors.initials: Q
authors.lastname: Hasan
authors.affiliation: Department of Biochemistry, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
authors.forename: Pragna
authors.initials: P
authors.lastname: Rao
keywords: PTDM; SLC30A8 and Asian Indians; TCF7L2; non-PTDM; rs13266634; rs7903146