title: Cilnidipine but not amlodipine suppresses sympathetic activation elicited by isometric exercise in hypertensive patients.
abstract: Pupillometry was used to evaluate the effects of the calcium channel blockers cilnidipine (CL) and amlodipine (AM) on changes in autonomic nervous activity induced by isometric exercise in patients with hypertension. After handgrip exercise, the velocity of miosis increased in both the CL and AM groups. However, the velocity of mydriasis increased in only the AM group. Velocity slopes of miosis and mydriasis were smaller in the CL group than in the AM group. The low-to-high frequency ratio obtained from pulse wave analysis increased in only the AM group. Sympathetic activation elicited by isometric exercise was suppressed more effectively by CL than by AM.
authors.affiliation: a Medical Education and Population-Based Medicine, Graduate School of Medicine, Wakayama Medical University , Wakayama , Japan .|b Department of Rehabilitation Medicine , School of Medicine, Wakayama Medical University , Wakayama , Japan , and.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Koike
authors.affiliation: a Medical Education and Population-Based Medicine, Graduate School of Medicine, Wakayama Medical University , Wakayama , Japan .
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawabe
authors.affiliation: a Medical Education and Population-Based Medicine, Graduate School of Medicine, Wakayama Medical University , Wakayama , Japan .
authors.forename: Kanami
authors.initials: K
authors.lastname: Nishihara
authors.affiliation: a Medical Education and Population-Based Medicine, Graduate School of Medicine, Wakayama Medical University , Wakayama , Japan .|c School of Health and Nursing Science, Wakayama Medical University , Wakayama , Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Iwane
authors.affiliation: a Medical Education and Population-Based Medicine, Graduate School of Medicine, Wakayama Medical University , Wakayama , Japan .
authors.forename: Takuzo
authors.initials: T
authors.lastname: Hano
mesh_terms: D000368:Aged; D017311:Amlodipine / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004095:Dihydropyridines / Q000494:pharmacology*; D015444:Exercise / Q000502:physiology; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015877:Miosis / Q000175:diagnosis / Q000503:physiopathology*; D015878:Mydriasis / Q000175:diagnosis / Q000503:physiopathology*; D011680:Pupil / Q000187:drug effects / Q000502:physiology; D015203:Reproducibility of Results
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D017311:Amlodipine; C065927:cilnidipine
keywords: Hypertension; miosis; mydriasis; pulse wave; pupillary function; sympathetic nerve activity