title: Testosterone replacement and cardiovascular safety: no straight and narrow!
abstract: The past decade has seen a tremendous increase in the number of men treated for hypogonadism with the expectation of symptomatic benefit. However, the long-term cardiovascular safety of testosterone replacement remains unknown because retrospective studies of testosterone replacement have been inconsistent, and definitive, prospective, randomized studies are lacking. The purpose of this review is to critically appraise the studies on testosterone replacement and cardiovascular outcomes.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
authors.forename: Sartaj S
authors.initials: SS
authors.lastname: Hans
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Texas Tech University Health Sciences Center - Permian Basin Campus, Odessa, TX, USA.
authors.forename: Sandeep S
authors.initials: SS
authors.lastname: Dhindsa
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Texas Tech University Health Sciences Center - Permian Basin Campus, Odessa, TX, USA.
authors.forename: Rama
authors.initials: R
authors.lastname: Chemitiganti
keywords: cardiovascular disease; hypogonadism; testosterone