title: The NLRP3-CASP1 Inflammasome Induces Glucocorticoid Resistance in ALL.
abstract: Overexpression of CASP1 and its activator NLRP3 confers glucocorticoid resistance in ALL.
mesh_terms: D002352:Carrier Proteins / Q000235:genetics*; D020170:Caspase 1 / Q000235:genetics*; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D058847:Inflammasomes / Q000235:genetics; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D005938:Glucocorticoids; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D011965:Receptors, Glucocorticoid; D020170:Caspase 1