title: Plasma N-terminal pro-B-type natriuretic peptide concentration in healthy retired racing Greyhounds.
abstract: BACKGROUND
  N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a cardiac biomarker whose plasma concentration is high in some dogs with cardiopulmonary disease. NT-proBNP is a diagnostic tool that can be used to help determine if a patient has congestive heart failure. Greyhounds have functional heart murmurs, relative cardiomegaly, and high serum cTnI concentration.
  
  
  OBJECTIVE
  The purpose of the study was to evaluate the plasma concentration of NT-proBNP in healthy Greyhounds and compare it to non-Greyhound dogs.
  
  
  METHODS
  We prospectively evaluated healthy client-owned dogs including retired racing Greyhounds and non-Greyhounds. Plasma was obtained and transferred into tubes containing a protease inhibitor and submitted for a specific NT-proBNP ELISA assay.
  
  
  RESULTS
  The plasma NT-proBNP concentration in Greyhounds was significantly higher than in non-Greyhound control dogs (946 vs 632 pmol/L; P < .005); 46% of Greyhounds had NT-proBNP > 1000 pmol/L.
  
  
  CONCLUSIONS
  Plasma NT-proBNP concentration in Greyhounds is high and should be interpreted with caution.
authors.affiliation: Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA.
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Couto
authors.affiliation: The Ohio State University Veterinary Medical Center, Columbus, OH, USA.
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Iazbik
authors.affiliation: Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA.
authors.forename: Liliana M
authors.initials: LM
authors.lastname: Marín
authors.affiliation: Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Zaldivar-López
authors.affiliation: IDEXX Laboratories, Westbrook, ME, USA.
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Beal
authors.affiliation: Vetoclock Telemedicine, Zaragoza, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Gómez Ochoa
authors.affiliation: Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA.|The Ohio State University College of Veterinary Medicine and Comprehensive Cancer Center, Columbus, OH, USA.|Vetoclock Telemedicine, Zaragoza, Spain.|Couto Veterinary Consultants, Hilliard, OH, USA.
authors.forename: C Guillermo
authors.initials: CG
authors.lastname: Couto
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000662:veterinary*; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011446:Prospective Studies; D013045:Species Specificity; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Athlete's heart; cardiac biomarkers; cardiac disease; congestive heart failure; sighthound