title: Metabolic Syndrome and Importance of Associated Variables in Children and Adolescents in Guabiruba - SC, Brazil.
abstract: BACKGROUND
  The risk factors that characterize metabolic syndrome (MetS) may be present in childhood and adolescence, increasing the risk of cardiovascular disease in adulthood.
  
  
  OBJECTIVE
  Evaluate the prevalence of MetS and the importance of its associated variables, including insulin resistance (IR), in children and adolescents in the city of Guabiruba-SC, Brazil.
  
  
  METHODS
  Cross-sectional study with 1011 students (6-14 years, 52.4% girls, 58.5% children). Blood samples were collected for measurement of biochemical parameters by routine laboratory methods. IR was estimated by the HOMA-IR index, and weight, height, waist circumference and blood pressure were determined. Multivariate logistic regression models were used to examine the associations between risk variables and MetS.
  
  
  RESULTS
  The prevalence of MetS, IR, overweight and obesity in the cohort were 14%, 8.5%, 21% and 13%, respectively. Among students with MetS, 27% had IR, 33% were overweight, 45.5% were obese and 22% were eutrophic. IR was more common in overweight (48%) and obese (41%) students when compared with eutrophic individuals (11%; p = 0.034). The variables with greatest influence on the development of MetS were obesity (OR = 32.7), overweight (OR = 6.1), IR (OR = 4.4; p ≤ 0.0001 for all) and age (OR = 1.15; p = 0.014).
  
  
  CONCLUSIONS
  There was a high prevalence of MetS in children and adolescents evaluated in this study. Students who were obese, overweight or insulin resistant had higher chances of developing the syndrome.
authors.affiliation: Universidade Federal de Santa Catarina, Florianópolis, SC, BR.
authors.forename: Nilton
authors.initials: N
authors.lastname: Rosini
authors.affiliation: 16ª Secretaria de Estado de Desenvolvimento Regional em Brusque, SC, BR.
authors.forename: Solange A Z Oppermann
authors.initials: SA
authors.lastname: Moura
authors.affiliation: 16ª Secretaria de Estado de Desenvolvimento Regional em Brusque, SC, BR.
authors.forename: Rodrigo Diegoli
authors.initials: RD
authors.lastname: Rosini
authors.affiliation: Universidade Federal de Santa Catarina, Florianópolis, SC, BR.
authors.forename: Marcos José
authors.initials: MJ
authors.lastname: Machado
authors.affiliation: Universidade Federal de Santa Catarina, Florianópolis, SC, BR.
authors.forename: Edson Luiz da
authors.initials: EL
authors.lastname: Silva
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001794:Blood Pressure; D049628:Body Size; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000209:etiology; D002648:Child; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology*; D063766:Pediatric Obesity / Q000453:epidemiology*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D007328:Insulin