title: Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the 'future' in dermatology therapeutics?
abstract: Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors and comprise three different isoforms namely PPARα, PPARγ, and PPARβ/δ with PPARβ/δ being the predominant subtype in human keratinocytes. After binding with specific ligands, PPARs regulate gene expression, cell growth and differentiation, apoptosis, inflammatory responses, and tumorogenesis. PPARs also modulate a wide variety of skin functions including keratinocyte proliferation, epidermal barrier formation, wound healing, melanocyte proliferation, and sebum production. Recent studies have shown the importance of PPARs in the pathogenesis of many dermatological disorders. Clinical trials have suggested possible role of PPAR agonists in the management of various dermatoses ranging from acne vulgaris, psoriasis, hirsutism, and lipodystrophy to cutaneous malignancies including melanoma. This article is intended to be a primer for dermatologists in their understanding of clinical relevance of PPARs and PPAR agonists in dermatology therapeutics.
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Tanda, 176001, Himachal Pradesh, India.
authors.forename: Mrinal
authors.initials: M
authors.lastname: Gupta
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Tanda, 176001, Himachal Pradesh, India. vkm1@rediffmail.com.
authors.forename: Vikram K
authors.initials: VK
authors.lastname: Mahajan
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Tanda, 176001, Himachal Pradesh, India.
authors.forename: Karaninder S
authors.initials: KS
authors.lastname: Mehta
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Tanda, 176001, Himachal Pradesh, India.
authors.forename: Pushpinder S
authors.initials: PS
authors.lastname: Chauhan
authors.affiliation: Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Tanda, 176001, Himachal Pradesh, India.
authors.forename: Ritu
authors.initials: R
authors.lastname: Rawat
mesh_terms: D018859:Hair Follicle / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D015603:Keratinocytes / Q000166:cytology / Q000473:pathology; D008544:Melanocytes / Q000166:cytology / Q000473:pathology; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists*; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology; D012879:Skin Physiological Phenomena; D014945:Wound Healing / Q000502:physiology
chemical_list: D047492:Peroxisome Proliferator-Activated Receptors
keywords: Acne vulgaris; Ciglitazone; Cutaneous malignancy; Dioic acid; PPAR agonists; PPARs; Peroxisome proliferator-activated receptors; Pioglitazone; Psoriasis; Rosiglitazone; Scleroderma; Thiazolidinediones; Troglitazone; Zileuton