title: Analysis of oxidative stress expressed by urinary level of biopyrrins and 8-hydroxydeoxyguanosine in patients with chronic schizophrenia.
abstract: OBJECTIVE
  Previous studies have supported the claim that psychological stress induces the production of reactive oxygen species. Several authors have suggested that patients with psychiatric disorders show high levels of oxidative stress markers. We examined different oxidative stress markers in patients with chronic schizophrenia.
  
  
  METHODS
  This study included 29 patients with chronic schizophrenia and 30 healthy volunteers. The concentration of urinary biopyrrins and 8-hydroxydeoxyguanosine (8-OHdG), as measured by enzyme-linked immunosorbent assay, were normalized to the urinary concentration of creatinine. Psychiatric symptoms were assessed by the administration of the Brief Psychiatric Rating Scale (BPRS).
  
  
  RESULTS
  The concentration of biopyrrins in patients with chronic schizophrenia was significantly higher when compared with healthy volunteers. The correlation between biopyrrin level and the duration of illness was highly significant. There were no significant differences in the levels of urinary 8-OHdG between the two groups. In schizophrenic patients, the level of urinary biopyrrins showed correlations with BPRS scores, while the level of urinary 8-OHdG did not show correlations with BPRS.
  
  
  CONCLUSIONS
  Urinary biopyrrins are increased in patients with chronic schizophrenia while urinary 8-OHdG is not increased. These findings suggest that patients with chronic schizophrenia are under the condition of certain oxidative stresses.
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyaoka
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Masa
authors.initials: M
authors.lastname: Ieda
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Hashioka
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Rei
authors.initials: R
authors.lastname: Wake
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Motohide
authors.initials: M
authors.lastname: Furuya
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Kristian
authors.initials: K
authors.lastname: Liaury
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Maiko
authors.initials: M
authors.lastname: Hayashida
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Tsuchie
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Arauchi
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Araki
authors.affiliation: Department of Research and Development, Shino-Test Corporation, Tokyo, Japan.
authors.forename: Izuru
authors.initials: I
authors.lastname: Shioji
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Ezoe
authors.affiliation: Department of Public Health, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Department of Biochemical Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Tokio
authors.initials: T
authors.lastname: Yamaguchi
authors.affiliation: Department of Psychiatry, Shimane University School of Medicine, Shimane, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D001663:Bilirubin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine*; D015415:Biomarkers; D016022:Case-Control Studies; D002908:Chronic Disease; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012559:Schizophrenia / Q000652:urine*
chemical_list: D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D001663:Bilirubin
keywords: 8-hydroxydeoxyguanosine; biopyrrins; chronic schizophrenia; oxidative stress markers; reactive oxygen species; urine