title: Review on synthesis of ferrocene-based redox polymers and derivatives and their application in glucose sensing.
abstract: The interest in glucose biosensors persisted over many years and persistent efforts have been made to develop long term stable glucose biosensors with precision, smart analytical performance, good linearity and resistance to communal interferences. In this regard, ferrocene-based polymers and derivatives (FBPDs) for the development of glucose biosensor (GBs) as redox mediators have acquired utmost attention of the scientists, especially in the second generation biosensors, as a large number of innovative molecules have been synthesized. Most of the FBPDs are considered as active components in the development of GBs, due to their ease of modification, biocompatibility, stability, large surface area, good electrical conductivity and especially excellent redox properties. This review provides a brief description of synthesis, analytical performance and glucose sensing application of ferrocene-based dendrimers, polythiophenes, polypyrroles, polyethylenimine, chitosan and carbon nano tubes (CNTs). Moreover, the analytical performance of ferrocene-based glucose biosensors (FBGBs) is summarized and the problems associated with the construction of GBs and the future trends are discussed.
authors.affiliation: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saleem
authors.affiliation: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: hjyu@zju.edu.cn.
authors.forename: Haojie
authors.initials: H
authors.lastname: Yu
authors.affiliation: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address: opl_wl@dial.zju.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
authors.lastname: Zain-ul-Abdin
authors.affiliation: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Hamad
authors.initials: H
authors.lastname: Khalid
authors.affiliation: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: M
authors.initials: M
authors.lastname: Akram
authors.affiliation: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Nasir M
authors.initials: NM
authors.lastname: Abbasi
authors.affiliation: State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods; D004867:Equipment Design; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D005947:Glucose / Q000032:analysis; D006801:Humans; D000075163:Metallocenes; D008958:Models, Molecular; D010084:Oxidation-Reduction; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001786:Blood Glucose; D005296:Ferrous Compounds; D000075163:Metallocenes; D011108:Polymers; D005947:Glucose; C004998:ferrocene
keywords: Ferrocene-based derivatives; Ferrocene-based polymers; Glucose biosensors; Mediator