title: Campylobacter-Associated Hemolytic Uremic Syndrome Associated with Pulmonary-Renal Syndrome.
abstract: Common causes of pulmonary-renal syndrome include anti-glomerular basement membrane (anti-GBM) disease anti-neutrophil cytoplasmic antibody (ANCA) positive vasculitis, and systemic lupus erythematosus. We describe a case of life-threatening pulmonary hemorrhage associated with Campylobacter hemolytic uremic syndrome (HUS), which we believe is a new disease entity. We hypothesize that the cause of this pulmonary-renal syndrome was an immunological reaction to Campylobacter; and that the initiation of high-dose steroids was responsible for the rapid reversal of the patient's pulmonary and renal impairment. The aim of this article is to raise awareness of this unusual cause of a pulmonary-renal syndrome, guiding physicians to recognize it as a potential complication, and to consider high-dose steroids in managing the condition.
authors.affiliation: Department of Nephrology, King's College Hospital, Denmark Hill, SE5 9RS, London, UK. bowene@doctors.org.uk.
authors.forename: Emily Elizabeth
authors.initials: EE
authors.lastname: Bowen
authors.affiliation: Department of Cellular Pathology, St. Thomas' Hospital, London, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Hangartner
authors.affiliation: Department of Nephrology, King's College Hospital, Denmark Hill, SE5 9RS, London, UK.
authors.forename: Iain
authors.initials: I
authors.lastname: Macdougall
mesh_terms: D002167:Campylobacter / Q000302:isolation & purification; D002169:Campylobacter Infections / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000000981:diagnostic imaging*; D006463:Hemolytic-Uremic Syndrome / Q000150:complications / Q000000981:diagnostic imaging*; D006470:Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
keywords: Campylobacter jejuni; hemolytic uremic syndrome; pulmonary hemorrhage