title: Nanoparticles functionalized with supramolecular host-guest systems for nanomedicine and healthcare.
abstract: Synthetic macrocyclic host compounds can interact with suitable guest molecules via noncovalent interactions to form functional supramolecular systems. With the synergistic integration of the response of molecules and the unique properties at the nanoscale, nanoparticles functionalized with the host-guest supramolecular systems have shown great potentials for a broad range of applications in the fields of nanoscience and nanotechnology. In this review article, we focus on the applications of the nanoparticles functionalized with supramolecular host-guest systems in nanomedicine and healthcare, including therapeutic delivery, imaging, sensing and removal of harmful substances. A large number of examples are included to elucidate the working mechanisms, advantages, limitations and future developments of the nanoparticle-supramolecule systems in these applications.
authors.forename: Zilong
authors.initials: Z
authors.lastname: Wu
authors.affiliation: 2State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China.
authors.forename: Nan
authors.initials: N
authors.lastname: Song
authors.forename: Ryan
authors.initials: R
authors.lastname: Menz
authors.forename: Bharadwaj
authors.initials: B
authors.lastname: Pingali
authors.affiliation: 2State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China.
authors.forename: Ying-Wei
authors.initials: YW
authors.lastname: Yang
authors.forename: Yuebing
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D003695:Delivery of Health Care; D050997:Nanomedicine; D053758:Nanoparticles; D013812:Therapeutics
keywords: healthcare; nanomedicine; nanoparticles; pollutant removals; sensing; supramolecular host–guest system; therapeutic delivery