title: Relationship between arrhythmogenic right ventricular dysplasia and exercise.
abstract: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is rare cardiomyopathy associated with life-threatening arrhythmias and increased risk of sudden cardiac death. In addition to mutations in desmosomal genes, environmental factors such as exercise have been implicated in the pathogenesis of the disease. Recent studies have shown that exercise may be associated with adverse outcomes in ARVD/C patients. Based on current evidence, ARVD/C patients are recommended to limit exercise irrespective of their mutation status. In addition, some studies have suggested the presence of an entirely acquired form of the disease caused by exercise that has been dubbed exercise-induced ARVD/C.
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA.
authors.forename: Abhishek C
authors.initials: AC
authors.lastname: Sawant
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA. Electronic address: hcalkins@jhmi.edu.
authors.forename: Hugh
authors.initials: H
authors.lastname: Calkins
mesh_terms: D019571:Arrhythmogenic Right Ventricular Dysplasia; D016757:Death, Sudden, Cardiac; D015444:Exercise; D006801:Humans
keywords: Arrhythmogenic right ventricular dysplasia/cardiomyopathy; Exercise; Exercise-induced cardiomyopathy; Sudden cardiac death