title: The application of color Doppler flow imaging in the diagnosis and therapeutic effect evaluation of erectile dysfunction.
abstract: We aim to investigate the correlations between hemodynamic parameters, penile rigidity grading, and the therapeutic effects of phosphodiesterase type 5 inhibitors using color Doppler flow imaging after intracavernosal injection in patients with erectile dysfunction. This study involved 164 patients. After intracavernosal injection with a mixture of papaverine (60 mg), prostaglandin E 1 (10 mg), and lidocaine (2%, 0.5-1 ml), the penile vessels were assessed using color Doppler flow imaging. Penile rigidity was classified based on the Erection Hardness Score system as Grades 4, 3, 2 or 1 (corresponding to Schramek Grades V to II). Then, the patients were given oral sildenafil (50-100 mg) and scored according to the International Index of Erectile Function (IIEF-5) questionnaire. The number of patients with penile rigidities of Schramek Grades II to V was 14, 18, 21, and 111, respectively. The IIEF-5 score was positively correlated with the refilling index of the penile cavernosal artery (r = 0.79, P< 0.05), the peak systolic velocity (r = 0.45, P< 0.05), and penile rigidity (r = 0.75, P< 0.05), and was negatively correlated with the end diastolic velocity (r = -0.74, P< 0.05). For patients with erectile dysfunction, both the IIEF-5 score after sildenafil administration, which is correlated with penile rigidity, and the hemodynamic parameters detected using color Doppler flow imaging may predict the effects of phosphodiesterase type 5 inhibitor treatment and could provide a reasonable model for the targeted-treatment of erectile dysfunction.
authors.forename: Xu-Jun
authors.initials: XJ
authors.lastname: Xuan
authors.forename: Gang
authors.initials: G
authors.lastname: Bai
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: Zhang
authors.forename: Chao
authors.initials: C
authors.lastname: Xu
authors.forename: Fu-Ding
authors.initials: FD
authors.lastname: Lu
authors.forename: Yang
authors.initials: Y
authors.lastname: Peng
authors.forename: Gang
authors.initials: G
authors.lastname: Ma
authors.affiliation: Department of Urology, The Affiliated School of Clinical Medicine, Xuzhou Medical College, Xuzhou, China.
authors.forename: Cong-Hui
authors.initials: CH
authors.lastname: Han
authors.affiliation: Department of Infertility and Sexual Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D007172:Erectile Dysfunction / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018615:Ultrasonography, Doppler, Color / Q000379:methods*; D055815:Young Adult