title: KPC and NDM-1 genes in related Enterobacteriaceae strains and plasmids from Pakistan and the United States.
abstract: To characterize the genomic context of New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC), we sequenced 78 Enterobacteriaceae isolates from Pakistan and the United States encoding KPC, NDM-1, or no carbapenemase. High similarities of the results indicate rapid spread of carbapenem resistance between strains, including globally disseminated pathogens.
authors.forename: Mitchell W
authors.initials: MW
authors.lastname: Pesesky
authors.forename: Tahir
authors.initials: T
authors.lastname: Hussain
authors.forename: Meghan
authors.initials: M
authors.lastname: Wallace
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Saadia
authors.initials: S
authors.lastname: Andleeb
authors.forename: Carey-Ann D
authors.initials: CA
authors.lastname: Burnham
authors.forename: Gautam
authors.initials: G
authors.lastname: Dantas
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology; D019295:Computational Biology / Q000379:methods; D004755:Enterobacteriaceae / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology*; D023281:Genomics / Q000379:methods; D006801:Humans; D008826:Microbial Sensitivity Tests; D010154:Pakistan / Q000453:epidemiology; D010957:Plasmids / Q000235:genetics*; D014481:United States / Q000453:epidemiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; C063912:carbapenemase
keywords: Carbapenems; Enterobacter; Enterobacteriaceae; Escherichia coli; Klebsiella infections; Klebsiella pneumonia; Pakistan; United States; antibiotic drugs; antimicrobial resistance; bacteria; beta-Lactam resistance; beta-Lactamases; beta-Lactams; gene transfer; genomics; multilocus sequence typing; next-generation sequencing; phylogeny; plasmids; transposases