title: Expression of metastasis-associated protein 3 in human brain glioma related to tumor prognosis.
abstract: Glioma represents a disparate group of tumors characterized by high invasion ability, and therefore it is of clinical significance to identify molecular markers and therapeutic targets for better clinical management. Previously, metastasis-associated protein family (MTA) is considered to promote tumor cell invasion and metastasis of human malignancies. Recently, the newly identified MTA3 has been shown to play conflicting roles in human malignancies, while the expression pattern and potential clinical significance of MTA3 in human glioma have not been addressed yet. In the present study, we investigated the protein expression of MTA3 by immunohistochemistry assay and analyzed its association with glioma prognosis in 186 cases of patients. Results showed that MTA3 expression was decreased in glioma compared with that in normal brain (P < 0.05). In addition, tumors with high MTA3 expression were more likely to be of low WHO grade (P = 0.005) and reserve of body function (P = 0.014). Survival analysis showed that decreased MTA3 expression was independently associated with unfavorable overall survival of patients (P < 0.001). These results provide the first evidence that MTA3 expression was decreased in human glioma and negatively associated with prognosis of patients, suggesting that MTA3 may play a tumor suppressor role in glioma.
authors.affiliation: Qingdao First Sanatorium of Jinan Military Region, Qingdao, 266071, Shandong, People's Republic of China. shanshouqin@yeah.net.
authors.forename: Shouqin
authors.initials: S
authors.lastname: Shan
authors.affiliation: Qingdao First Sanatorium of Jinan Military Region, Qingdao, 266071, Shandong, People's Republic of China.
authors.forename: Guangyan
authors.initials: G
authors.lastname: Hui
authors.affiliation: Qingdao Second Sanatorium of Jinan Military Region, Qingdao, 266071, Shandong, People's Republic of China.
authors.forename: Fanggao
authors.initials: F
authors.lastname: Hou
authors.affiliation: Qingdao First Sanatorium of Jinan Military Region, Qingdao, 266071, Shandong, People's Republic of China.
authors.forename: Hua
authors.initials: H
authors.lastname: Shi
authors.affiliation: Qingdao First Sanatorium of Jinan Military Region, Qingdao, 266071, Shandong, People's Republic of China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Zhou
authors.affiliation: Qingdao First Sanatorium of Jinan Military Region, Qingdao, 266071, Shandong, People's Republic of China.
authors.forename: Han
authors.initials: H
authors.lastname: Yan
authors.affiliation: Qingdao First Sanatorium of Jinan Military Region, Qingdao, 266071, Shandong, People's Republic of China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Qingdao First Sanatorium of Jinan Military Region, Qingdao, 266071, Shandong, People's Republic of China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Liu
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D005260:Female; D015870:Gene Expression; D005910:Glioma / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D011379:Prognosis; D016016:Proportional Hazards Models; D016896:Treatment Outcome; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: D015415:Biomarkers; C486657:MTA3 protein, human; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes
keywords: Glioma; Immunohistochemistry; MTA3; Prognosis