title: Initial Experience with IV Ketamine Infusion for Treatment of Post Sternotomy Pain in a Patient with a Total Artificial Heart.
abstract: The implantation of total artificial hearts (TAH) via midline sternotomy for the treatment of severe biventricular cardiac dysfunction is associated with complex postoperative pain management. Ketamaine increases blood pressure by raising sympathetic outflow and cardiac output; however, ketamine is a direct vasodilator on isolated arterial tissues. In the setting of a TAH with a mechanically fixed cardiac output, a ketamine infusion for postoperative pain control has the potential to decrease blood pressure due to direct arterial vasodilation. We present the initial experience with a ketamine infusion in a patient with a TAH with minimal observed decreases in blood pressure and significantly improved postoperative pain.
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, CA.
authors.forename: Dermot P
authors.initials: DP
authors.lastname: Maher
authors.forename: Rusty
authors.initials: R
authors.lastname: Loyferman
authors.forename: Roya
authors.initials: R
authors.lastname: Yumul
authors.forename: Charles
authors.initials: C
authors.lastname: Louy
mesh_terms: D000328:Adult; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D006354:Heart, Artificial; D006801:Humans; D007262:Infusions, Intravenous; D007649:Ketamine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D019919:Prosthesis Implantation; D056346:Sternotomy / Q000009:adverse effects*
chemical_list: D000778:Anesthetics, Dissociative; D007649:Ketamine