title: Cell biology. On being the right (cell) size.
abstract: Different animal cell types have distinctive and characteristic sizes. How a particular cell size is specified by differentiation programs and physiology remains one of the fundamental unknowns in cell biology. In this Review, we explore the evidence that individual cells autonomously sense and specify their own size. We discuss possible mechanisms by which size-sensing and size-specification may take place. Last, we explore the physiological implications of size control: Why is it important that particular cell types maintain a particular size? We develop these questions through examination of the current literature and pose the questions that we anticipate will guide this field in the upcoming years.
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
authors.forename: Miriam B
authors.initials: MB
authors.lastname: Ginzberg
authors.affiliation: The Hospital for Sick Children, Toronto, Canada.
authors.forename: Ran
authors.initials: R
authors.lastname: Kafri
authors.affiliation: Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Kirschner
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D048429:Cell Size; D004847:Epithelial Cells / Q000166:cytology; D005260:Female; D016193:G1 Phase; D006801:Humans; D042361:Mammary Glands, Human / Q000166:cytology; D051379:Mice