title: The frontotemporal dementias.
abstract: Frontotemporal dementia (FTD) is a heterogeneous group of hereditary and sporadic neurodegenerative disorders affecting frontotemporal areas. FTD, a leading cause of young-onset dementia, is often initially mistaken for primary psychiatric disorders. Based on early and predominant symptoms, different clinical syndromes can be distinguished: the behavioral variant and 2 variants of progressive aphasia; semantic dementia and progressive nonfluent aphasia. Neuropathological classification is based on protein accumulation in the brain. Pathogenic mutations in different genes have been identified. Specific pharmacological treatment is the main research goal. Meanwhile the management must focus on early correct diagnosis, symptom alleviation, caregiver support and educational interventions.
authors.affiliation: Section of Geriatric Psychiatry, Department of Clinical Sciences, Lund University, Klinikgatan 22, Lund SE-221 85, Sweden. Electronic address: maria.landqvist@med.lu.se.
authors.forename: Maria Landqvist
authors.initials: ML
authors.lastname: Waldö
mesh_terms: D001526:Behavioral Symptoms / Q000175:diagnosis; D000073885:C9orf72 Protein; D003951:Diagnostic Errors / Q000517:prevention & control*; D057180:Frontotemporal Dementia / Q000175:diagnosis / Q000235:genetics / Q000523:psychology / Q000628:therapy; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods; D010552:Personality Assessment; D011506:Proteins / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D011619:Psychotropic Drugs / Q000627:therapeutic use*
chemical_list: D000073885:C9orf72 Protein; C568651:C9orf72 protein, human; D008869:Microtubule-Associated Proteins; D011506:Proteins; D011619:Psychotropic Drugs
keywords: Behavioral variant; FTD; Frontotemporal dementia; Neuropsychiatric symptoms; Progressive aphasia