title: Visible light-induced singlet oxygen-mediated intracellular disassembly of polymeric micelles co-loaded with a photosensitizer and an anticancer drug for enhanced photodynamic therapy.
abstract: Herein, we report a biocompatible amphiphilic block copolymer micelle bearing a singlet oxygen-sensitive vinyldithioether cleavable linker at the core-shell junction, which undergoes singlet oxygen-mediated photocleavage in the presence of visible light. The micelle facilitates the light-responsive release of singlet oxygen and an anticancer drug for enhanced photodynamic therapy.
authors.affiliation: Center for Self-assembly and Complexity, Institute of Basic Science (IBS), and Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea. wjkim@postech.ac.kr.
authors.forename: Gurusamy
authors.initials: G
authors.lastname: Saravanakumar
authors.forename: Junseok
authors.initials: J
authors.lastname: Lee
authors.forename: Jihoon
authors.initials: J
authors.lastname: Kim
authors.forename: Won Jong
authors.initials: WJ
authors.lastname: Kim
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000737:chemistry* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry; D015195:Drug Design; D065546:Drug Liberation; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D007783:Lactones / Q000737:chemistry*; D008027:Light; D008823:Micelles; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry*; D026082:Singlet Oxygen / Q000378:metabolism*; D013440:Sulfides / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D004337:Drug Carriers; D007783:Lactones; D008823:Micelles; D017319:Photosensitizing Agents; D013440:Sulfides; C521904:poly(ethylene glycol)-block-poly(epsilon-caprolactone); D026082:Singlet Oxygen; D011092:Polyethylene Glycols; D004317:Doxorubicin