title: Bioengineered Corneas Grafted as Alternatives to Human Donor Corneas in Three High-Risk Patients.
abstract: Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered from corneal ulcers and recurrent erosions preoperatively. The implants provided relief from pain and discomfort, restored corneal integrity by promoting endogenous regeneration of corneal tissues, and improved vision in two of three patients. Such implants could in the future be alternatives to donor corneas for high-risk patients, and therefore, merits further testing in a clinical trial.
authors.affiliation: Filatov Institute of Eye Diseases and Tissue Therapy of the, National Academy of Medical Sciences of Ukraine, Odessa, Ukraine.|Integrative Regenerative Medicine Center, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
authors.forename: Oleksiy
authors.initials: O
authors.lastname: Buznyk
authors.affiliation: Filatov Institute of Eye Diseases and Tissue Therapy of the, National Academy of Medical Sciences of Ukraine, Odessa, Ukraine.
authors.forename: Nataliya
authors.initials: N
authors.lastname: Pasyechnikova
authors.affiliation: Integrative Regenerative Medicine Center, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.|Department of Neurosciences, Swedish Medical Nanoscience Center, Karolinska Institutet, Stockholm, Sweden.
authors.forename: M Mirazul
authors.initials: MM
authors.lastname: Islam
authors.affiliation: Filatov Institute of Eye Diseases and Tissue Therapy of the, National Academy of Medical Sciences of Ukraine, Odessa, Ukraine.
authors.forename: Stanislav
authors.initials: S
authors.lastname: Iakymenko
authors.affiliation: Integrative Regenerative Medicine Center, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Fagerholm
authors.affiliation: Integrative Regenerative Medicine Center, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.|Department of Neurosciences, Swedish Medical Nanoscience Center, Karolinska Institutet, Stockholm, Sweden.
authors.forename: May
authors.initials: M
authors.lastname: Griffith
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002057:Burns, Chemical / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D016039:Corneal Transplantation / Q000009:adverse effects / Q000379:methods*; D003320:Corneal Ulcer / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D005126:Eye Burns / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D020007:Implants, Experimental; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D020127:Recovery of Function; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D023822:Tissue Engineering / Q000379:methods*; D016896:Treatment Outcome; D014785:Vision, Ocular
keywords: collagen; epithelium; grafting; patients; remodeling; transplantation