title: COMPARING THE OUTCOME OF SINGLE VERSUS MULTIPLE SESSION LASER PHOTOABLATION OF FLAT NEOVASCULARIZATION IN ZONE 1 AGGRESSIVE POSTERIOR RETINOPATHY OF PREMATURITY: A Prospective Randomized Study.
abstract: OBJECTIVE
  To compare single versus 2-session laser photoablation for flat neovascularization in cases with Zone 1 aggressive posterior retinopathy of prematurity.
  
  
  METHODS
  Twenty-nine Asian Indian infants with aggressive posterior retinopathy of prematurity were randomized; each eye received 1 of 2 methods (29 each in Group A or B) proposed by the PHOTO-ROP group. Group A underwent single session laser to the avascular retina underlying the flat neovascularization by direct laser over the fronds. Group B underwent laser in 2 sessions; first, laser was delivered to the avascular periphery up to the flat neovascularization and 7 days later to the avascular bed exposed by the retraction of the fronds. Outcome and complications between the two groups were compared.
  
  
  RESULTS
  Mean birthweight and gestational ages were 1,276 g and 30.1 weeks, respectively. All eyes showed favorable outcome at a minimum 12-month follow-up. Hemorrhages after laser (41.4% vs. 17.2%, P < 0.001) were more common in the single laser group. Large hemorrhages (>1 disk diameter) seen in Group A took longer than 8 weeks to resolve and developed focal fibrosis.
  
  
  CONCLUSIONS
  This study demonstrates that the two-staged laser procedure produces fewer and smaller hemorrhages and no fibrosis compared with a single session. Both methods have comparable favorable outcomes in Asian Indian infants.
authors.affiliation: *Department of Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India; †Faculty of Ophthalmology, Maastricht University, Maastricht, the Netherlands; and ‡Associated Retinal Consultants, William Beaumont Hospital, Royal Oak, Michigan.
authors.forename: Anand
authors.initials: A
authors.lastname: Vinekar
authors.forename: Chaitra
authors.initials: C
authors.lastname: Jayadev
authors.forename: Shwetha
authors.initials: S
authors.lastname: Mangalesh
authors.forename: Anupama Kiran
authors.initials: AK
authors.lastname: Kumar
authors.forename: Noel
authors.initials: N
authors.lastname: Bauer
authors.forename: Antonio
authors.initials: A
authors.lastname: Capone
authors.forename: Michael
authors.initials: M
authors.lastname: Trese
authors.forename: Bhujang
authors.initials: B
authors.lastname: Shetty
mesh_terms: D001724:Birth Weight; D005355:Fibrosis; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D017075:Laser Coagulation / Q000009:adverse effects / Q000379:methods*; D011183:Postoperative Complications; D011446:Prospective Studies; D012160:Retina / Q000473:pathology; D012166:Retinal Hemorrhage / Q000209:etiology / Q000517:prevention & control; D015861:Retinal Neovascularization / Q000503:physiopathology / Q000601:surgery*; D012178:Retinopathy of Prematurity / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome