title: Bio-Enabled Gold Superstructures with Built-In and Accessible Electromagnetic Hotspots.
abstract: The bio-enabled synthesis of a novel class of surface enhanced Raman scattering probes is presented for functional imaging with built-in and accessible electromagnetic hotspots formed between densely packed satellites grown on a plasmonic core. The superstructures serve as nanoscale sensors to spatiotemporally map intravesicular pH changes along endocytic pathways inside live cells.
authors.affiliation: Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
authors.forename: Limei
authors.initials: L
authors.lastname: Tian
authors.affiliation: Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
authors.forename: Max
authors.initials: M
authors.lastname: Fei
authors.affiliation: Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
authors.forename: Sirimuvva
authors.initials: S
authors.lastname: Tadepalli
authors.affiliation: Department of Anesthesiology, Division of Clinical and Translational Research, Washington University in St. Louis, St. Louis, MO, 63110, USA.|Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, 63110, USA.
authors.forename: Jeremiah J
authors.initials: JJ
authors.lastname: Morrissey
authors.affiliation: Department of Anesthesiology, Division of Clinical and Translational Research, Washington University in St. Louis, St. Louis, MO, 63110, USA.|Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, 63110, USA.|Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis, St. Louis, MO, 63110, USA.
authors.forename: Evan D
authors.initials: ED
authors.lastname: Kharasch
authors.affiliation: Department of Mechanical Engineering and Materials Science, Institute of Materials Science and Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.|Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, 63110, USA.
authors.forename: Srikanth
authors.initials: S
authors.lastname: Singamaneni
mesh_terms: D045744:Cell Line, Tumor; D058948:Cell Tracking; D005089:Exocytosis; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011137:Polystyrenes / Q000737:chemistry; D013059:Spectrum Analysis, Raman
chemical_list: D011137:Polystyrenes; C003321:polystyrene sulfonic acid; D006046:Gold
keywords: electromagnetic hotspots; functional bioimaging; plasmonic nanostructures; surface enhanced Raman scattering