title: Dynamic changes in plasma tissue plasminogen activator, plasminogen activator inhibitor-1 and beta-thromboglobulin content in ischemic stroke.
abstract: The aim of this paper is to investigate the corresponding variations of plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activities, and beta-thromboglobulin (β-TG) content in patients during different stages of ischemic stroke. Ischemic stroke is a common disease among aging people and its occurrence is associated with abnormalities in the fibrinolytic system and platelet function. However, few reports focus on the dynamic changes in the plasma fibrinolytic system and β-TG content in patients with ischemic stroke. Patients were divided into three groups: acute, convalescent and chronic. Plasma t-PA and PAI-1 activities were determined by chromogenic substrate analysis and plasma β-TG content was detected by radioimmunoassay. Patients in the acute stage of ischemic stroke had significantly increased levels of t-PA activity and β-TG content, but PAI-1 activity was significantly decreased. Negative correlations were found between plasma t-PA and PAI-1 activities and between plasma t-PA activity and β-TG content in patients with acute ischemic stroke. There were significant differences in plasma t-PA and PAI-1 activities in the aged control group, as well as in the acute, convalescent and chronic groups. It can be speculated that the increased activity of t-PA in patients during the acute stage was the result of compensatory function, and that the increase in plasma β-TG level not only implies the presence of ischemic stroke but is likely a cause of ischemic stroke. During the later stages of ischemic stroke, greater attention is required in monitoring levels of PAI-1.
authors.affiliation: Shanghai International Medical Center, Shanghai, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhuang
authors.affiliation: Department of Central Laboratory, Shanghai East Hospital, Tongji University, 150 Jimo Road, Pudong New District, Shanghai 200120, People's Republic of China.
authors.forename: Da
authors.initials: D
authors.lastname: Wo
authors.affiliation: Department of Central Laboratory, Shanghai East Hospital, Tongji University, 150 Jimo Road, Pudong New District, Shanghai 200120, People's Republic of China.
authors.forename: Zeng-Guang
authors.initials: ZG
authors.lastname: Xu
authors.affiliation: Department of Central Laboratory, Shanghai East Hospital, Tongji University, 150 Jimo Road, Pudong New District, Shanghai 200120, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
authors.affiliation: Department of Central Laboratory, Shanghai East Hospital, Tongji University, 150 Jimo Road, Pudong New District, Shanghai 200120, People's Republic of China. Electronic address: mhuim@163.com.
authors.forename: Hui-ming
authors.initials: HM
authors.lastname: Mao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002545:Brain Ischemia / Q000378:metabolism*; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D020521:Stroke / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000097:blood*; D001620:beta-Thromboglobulin / Q000378:metabolism*
chemical_list: C061615:PPBP protein, human; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D001620:beta-Thromboglobulin; C067262:PLAT protein, human; D010959:Tissue Plasminogen Activator
keywords: Beta–thromboglobulin; Ischemic stroke; Plasma; Plasminogen activator inhibitor-1; Tissue plasminogen activator