title: Acetic acid enhances endurance capacity of exercise-trained mice by increasing skeletal muscle oxidative properties.
abstract: Acetic acid has been shown to promote glycogen replenishment in skeletal muscle during exercise training. In this study, we investigated the effects of acetic acid on endurance capacity and muscle oxidative metabolism in the exercise training using in vivo mice model. In exercised mice, acetic acid induced a significant increase in endurance capacity accompanying a reduction in visceral adipose depots. Serum levels of non-esterified fatty acid and urea nitrogen were significantly lower in acetic acid-fed mice in the exercised mice. Importantly, in the mice, acetic acid significantly increased the muscle expression of key enzymes involved in fatty acid oxidation and glycolytic-to-oxidative fiber-type transformation. Taken together, these findings suggest that acetic acid improves endurance exercise capacity by promoting muscle oxidative properties, in part through the AMPK-mediated fatty acid oxidation and provide an important basis for the application of acetic acid as a major component of novel ergogenic aids.
authors.affiliation: a Department of Food and Biotechnology , Korea University , Sejong , Republic of Korea.
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Pan
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyung Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Eui Seop
authors.initials: ES
authors.lastname: Lee
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Shin
authors.forename: Seongpil
authors.initials: S
authors.lastname: Kim
authors.forename: Minkyeong
authors.initials: M
authors.lastname: Shin
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Jin Hyup
authors.initials: JH
authors.lastname: Lee
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Kim
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage*; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D006003:Glycogen / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D010805:Physical Conditioning, Animal; D010807:Physical Endurance / Q000187:drug effects*
chemical_list: D006003:Glycogen; D019342:Acetic Acid
keywords: acetic acid; exercise training; mouse; muscle protein expression; oxidative properties