title: Prefrontal cortex afferents to the anterior temporal lobe in the Macaca fascicularis monkey.
abstract: The anatomical organization of the lateral prefrontal cortex (LPFC) afferents to the anterior part of the temporal lobe (ATL) remains to be clarified. The LPFC has two subdivisions, dorsal (dLPFC) and ventral (vLPFC), which have been linked to cognitive processes. The ATL includes several different cortical areas, namely, the temporal polar cortex and rostral parts of the perirhinal, inferotemporal, and anterior tip of the superior temporal gyrus cortices. Multiple sensory modalities converge in the ATL. All of them (except the rostral inferotemporal and superior temporal gyrus cortices) are components of the medial temporal lobe, which is critical for long-term memory processing. We studied the LPFC connections with the ATL by placing retrograde tracer injections into the ATL: the temporal polar (n = 3), perirhinal (areas 35 and 36, n = 6), and inferotemporal cortices (area TE, n = 5), plus one additional deposit in the posterior parahippocampal cortex (area TF, n = 1). Anterograde tracer deposits into the dLPFC (A9 and A46, n = 2), the vLPFC (A46v, n = 2), and the orbitofrontal cortex (OF; n = 2) were placed for confirmation of those projections. The results showed that the vLPFC displays a moderate projection to rostral area TE and the dorsomedial portion of the temporal polar cortex; in contrast, the dLPFC connections with the ATL were weak. By comparison, the OFC and medial frontal cortices (MFC) showed dense connectivity with the ATL, namely, A13 with the temporopolar and perirhinal cortices. All areas of the MFC projected to the temporopolar cortex, albeit with a lower intensity. The functional significance of such paucity of LPFC afferents is unknown.
authors.affiliation: Department of Health Sciences, University of Castilla-La Mancha, Albacete, 02006, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Mohedano-Moriano
authors.affiliation: Department of Health Sciences, University of Castilla-La Mancha, Albacete, 02006, Spain.
authors.forename: Mónica
authors.initials: M
authors.lastname: Muñoz-López
authors.affiliation: Radiology and Image Analysis Center - Free University Medical center (VUmc), Amsterdam, The Netherlands.
authors.forename: Ernesto
authors.initials: E
authors.lastname: Sanz-Arigita
authors.affiliation: UNICAEN, UMS 3408, GIP Cyceron, Campus Jules Horowiz, 1474, Caen, France.
authors.forename: Palma
authors.initials: P
authors.lastname: Pró-Sistiaga
authors.affiliation: Department of Health Sciences, University of Castilla-La Mancha, Ciudad Real, 13071, Spain.
authors.forename: Alino
authors.initials: A
authors.lastname: Martínez-Marcos
authors.affiliation: Department of Health Sciences, University of Castilla-La Mancha, Albacete, 02006, Spain.
authors.forename: María Ester
authors.initials: ME
authors.lastname: Legidos-Garcia
authors.affiliation: Department of Health, Physical Therapy School, Public University of Navarre, Tudela Campus, 31005, Tudela, Spain.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Insausti
authors.affiliation: Department of Health Sciences, University of Castilla-La Mancha, Albacete, 02006, Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: Cebada-Sánchez
authors.affiliation: Department of Health Sciences, University of Castilla-La Mancha, Albacete, 02006, Spain.
authors.forename: María Del Mar
authors.initials: Mdel M
authors.lastname: Arroyo-Jiménez
authors.affiliation: Department of Health Sciences, University of Castilla-La Mancha, Albacete, 02006, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: Marcos
authors.affiliation: Department of Health Sciences, University of Castilla-La Mancha, Albacete, 02006, Spain.
authors.forename: Emilio
authors.initials: E
authors.lastname: Artacho-Pérula
authors.affiliation: Department of Health Sciences, University of Castilla-La Mancha, Albacete, 02006, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Insausti
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000578:Amidines / Q000378:metabolism; D000818:Animals; D001710:Biotin / Q000031:analogs & derivatives / Q000378:metabolism; D001931:Brain Mapping; D003911:Dextrans / Q000378:metabolism; D005215:Fasting; D008252:Macaca fascicularis / Q000033:anatomy & histology*; D008297:Male; D017397:Prefrontal Cortex / Q000033:anatomy & histology*; D013702:Temporal Lobe / Q000033:anatomy & histology*; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate / Q000378:metabolism
chemical_list: D000578:Amidines; D003911:Dextrans; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; C076397:biotinylated dextran amine; C031455:diamidino compound 253-50; D001710:Biotin
keywords: afferents; anterior temporal cortex; nonhuman primate; prefrontal cortex