title: Eye movements as probes of lexico-semantic processing in a patient with primary progressive aphasia.
abstract: Eye movement trajectories during a verbally cued object search task were used as probes of lexico-semantic associations in an anomic patient with primary progressive aphasia. Visual search was normal on trials where the target object could be named but became lengthy and inefficient on trials where the object failed to be named. The abnormality was most profound if the noun denoting the object could not be recognized. Even trials where the name of the target object was recognized but not retrieved triggered abnormal eye movements, demonstrating that retrieval failures can have underlying associative components despite intact comprehension of the corresponding noun.
authors.affiliation: a Cognitive Neurology and Alzheimer's Disease Center , Northwestern University , Chicago , IL , USA.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Seckin
authors.affiliation: a Cognitive Neurology and Alzheimer's Disease Center , Northwestern University , Chicago , IL , USA.
authors.forename: M-Marsel
authors.initials: MM
authors.lastname: Mesulam
authors.affiliation: a Cognitive Neurology and Alzheimer's Disease Center , Northwestern University , Chicago , IL , USA.|b Department of Preventive Medicine , Northwestern University , Chicago , IL , USA.
authors.forename: Alfred W
authors.initials: AW
authors.lastname: Rademaker
authors.affiliation: c Department of Medical Social Sciences , Northwestern University , Chicago , IL , USA.
authors.forename: Joel L
authors.initials: JL
authors.lastname: Voss
authors.affiliation: a Cognitive Neurology and Alzheimer's Disease Center , Northwestern University , Chicago , IL , USA.
authors.forename: Sandra
authors.initials: S
authors.lastname: Weintraub
authors.affiliation: a Cognitive Neurology and Alzheimer's Disease Center , Northwestern University , Chicago , IL , USA.
authors.forename: Emily J
authors.initials: EJ
authors.lastname: Rogalski
authors.affiliation: a Cognitive Neurology and Alzheimer's Disease Center , Northwestern University , Chicago , IL , USA.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Hurley
mesh_terms: D000368:Aged; D018888:Aphasia, Primary Progressive / Q000503:physiopathology* / Q000523:psychology; D032882:Comprehension / Q000502:physiology*; D003463:Cues; D005133:Eye Movements / Q000502:physiology*; D005260:Female; D006801:Humans; D007807:Language Tests; D008875:Middle Aged; D009483:Neuropsychological Tests
keywords: anterior temporal lobe; aphasia; eye movements; object naming; single-word comprehension