title: Association between endometriosis and hyperprolactinemia in infertile women.
abstract: BACKGROUND
  The association of endometriosis with hyperprolactinemia is controversial.
  
  
  OBJECTIVE
  The present study aimed to determine the frequency of endometriosis and association of prolactin with endometriosis in infertile women.
  
  
  METHODS
  256 infertile women who underwent diagnostic laparoscopy for the evaluation of infertility, referred to Fatemezahra Infertility and Reproductive Health Research Center were included in a cross-sectional study. The presence of endometriosis was evaluated. To investigate the association of endometriosis with hyperprolactinemia, the patients whose infertility was not caused by endometriosis were included as control group. Serum prolactin (PRL) level was measured in both groups. The comparison of basal serum PRL levels between the two groups was performed, using independent t-test. One way ANOVA was used to determine PRL association with endometriosis stages.
  
  
  RESULTS
  The frequency of endometriosis was found to be 29%. PRL levels were significantly higher in endometriosis group compared to control group (23.02±1.25 vs. 17.22±1.22 respectively, p=0.004). Statistically significant associations were found between staging of endometriosis and prolactin levels (p=0.01).
  
  
  CONCLUSIONS
  Hyperprolactinemia may be associated with endometriosis and its progression.
authors.affiliation: Fatemeh-zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Seddigheh
authors.initials: S
authors.lastname: Esmaeilzadeh
authors.affiliation: Fatemeh-zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Parvaneh
authors.initials: P
authors.lastname: Mirabi
authors.affiliation: Fatemeh-zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Basirat
authors.affiliation: Fatemeh-zahra Infertility and Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mahtab
authors.initials: M
authors.lastname: Zeinalzadeh
authors.affiliation: Department of Biostatistics and Epidemiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Soraya
authors.initials: S
authors.lastname: Khafri
keywords: Endometriosis; Hyperprolactinemia; Infertility; Laparoscopy