title: Cell or cell membrane-based drug delivery systems.
abstract: Natural cells have been explored as drug carriers for a long period. They have received growing interest as a promising drug delivery system (DDS) until recently along with the development of biology and medical science. The synthetic materials, either organic or inorganic, are found to be with more or less immunogenicity and/or toxicity. The cells and extracellular vesicles (EVs), are endogenous and thought to be much safer and friendlier. Furthermore, in view of their host attributes, they may achieve different biological effects and/or targeting specificity, which can meet the needs of personalized medicine as the next generation of DDS. In this review, we summarized the recent progress in cell or cell membrane-based DDS and their fabrication processes, unique properties and applications, including the whole cells, EVs and cell membrane coated nanoparticles. We expect the continuing development of this cell or cell membrane-based DDS will promote their clinic applications.
authors.affiliation: 1. Tongji School of Pharmacy; ; 2. National Engineering Research Center for Nanomedicine; ; 3. Hubei Engineering Research Center for Novel DDS, Huazhong University of Science and Technology, Wuhan 430030, P R China.
authors.forename: Songwei
authors.initials: S
authors.lastname: Tan
authors.affiliation: 1. Tongji School of Pharmacy;
authors.forename: Tingting
authors.initials: T
authors.lastname: Wu
authors.affiliation: 1. Tongji School of Pharmacy;
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: 1. Tongji School of Pharmacy; ; 2. National Engineering Research Center for Nanomedicine; ; 3. Hubei Engineering Research Center for Novel DDS, Huazhong University of Science and Technology, Wuhan 430030, P R China.
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D002477:Cells / Q000378:metabolism*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D055808:Drug Discovery / Q000639:trends; D006801:Humans; D057285:Precision Medicine / Q000379:methods
chemical_list: D004337:Drug Carriers
keywords: cell membrane; drug delivery system; extracellular vesicle; nanoparticle; tumor