title: Association between Angiotensin I-Converting Enzyme Insertion/Deletion Polymorphism and Prognosis of Kidney Transplantation: A Meta-Analysis.
abstract: OBJECTIVE
  Angiotensin I-converting enzyme (ACE) is crucial in the renin-angiotensin-aldosterone system. ACE insertion/deletion (I/D) polymorphism is a common genetic variation of this gene and is associated with several disease phenotypes. However, the results of published studies on the influence of this polymorphism on renal transplantation are inconsistent. Therefore, a meta-analysis was performed to evaluate the association between ACE I/D polymorphism and prognosis of kidney transplantation.
  
  
  METHODS
  A meta-analysis was performed based on 21 case-control studies from 12 publications (1497 cases and 2029 controls) and 10 studies with quantitative values from 5 publications (814 patients). Pooled odds ratios (ORs) and weighted mean differences (WMDs) with their corresponding 95% confidence intervals (CIs) were used to estimate associations.
  
  
  RESULTS
  ACE I/D polymorphism was found to be associated with acute rejection (AR) in genotypes DD+ID versus II (OR = 1.62, 95% CI = 1.14-2.29) and with serum creatinine concentration after renal transplantation in genotypes DD versus ID (WMD = 13.12, 95% CI = 8.09-18.16). Stratified analysis revealed that recipients transplanted within a year had higher serum creatinine concentrations in the DD versus ID model. No significant association was found between hypertension and ACE I/D polymorphism.
  
  
  CONCLUSIONS
  ACE I/D polymorphism is associated with AR and allograft function after kidney transplantation.
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Zhengkai
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Bian
authors.initials: B
authors.lastname: Wu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Tao
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Han
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Xuzhong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Zijie
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Ruoyun
authors.initials: R
authors.lastname: Tan
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Min
authors.initials: M
authors.lastname: Gu
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
authors.forename: Changjun
authors.initials: C
authors.lastname: Yin
mesh_terms: D016022:Case-Control Studies; D056726:Genetic Association Studies; D006084:Graft Rejection / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D051437:Renal Insufficiency / Q000235:genetics* / Q000601:surgery*; D012084:Renin-Angiotensin System / Q000235:genetics
chemical_list: D007703:Peptidyl-Dipeptidase A