title: Partial protein domains: evolutionary insights and bioinformatics challenges.
abstract: Protein domains are generally thought to correspond to units of evolution. New research raises questions about how such domains are defined with bioinformatics tools and sheds light on how evolution has enabled partial domains to be viable.
authors.affiliation: Structural Bioinformatics Group, Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK. l.a.kelley@imperial.ac.uk.
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Kelley
authors.affiliation: Structural Bioinformatics Group, Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK. m.sternberg@imperial.ac.uk.
authors.forename: Michael J E
authors.initials: MJ
authors.lastname: Sternberg
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics*; D017353:Gene Deletion; D005798:Genes, Bacterial; D006801:Humans; D008156:Luciferases / Q000235:genetics*; D058977:Molecular Sequence Annotation; D010088:Oxidoreductases / Q000235:genetics*; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D016415:Sequence Alignment
chemical_list: D001426:Bacterial Proteins; D011506:Proteins; D010088:Oxidoreductases; C063122:luxG protein, Bacteria; D008156:Luciferases