title: Systemic treatment of vulvar cancer.
abstract: Squamous cell carcinoma of the vulva is a rare disease, accounting for approximately 5% of cancers of the female genital tract. Standard therapy for early-stage vulvar cancer mainly comprises of surgery of the vulva and groins. In locally advanced or metastatic vulvar cancer, neoadjuvant or definitive chemoradiation is often considered as an alternative treatment option. Given its rarity, the level of evidence for different treatment modalities is poor and few clinical trials have been performed on this disease. Therefore indication criteria for systemic treatment in advanced stage vulvar cancer vary widely among countries and institutions. This review focuses on the different systemic treatment options for patients with locally advanced, recurrent or metastatic vulvar cancer, and highlights the need for an international multicenter approach to identify the most effective therapeutic options.
authors.affiliation: Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Hamburg 20246, Germany.
authors.forename: Sven
authors.initials: S
authors.lastname: Mahner
authors.forename: Katharina
authors.initials: K
authors.lastname: Prieske
authors.forename: Donata
authors.initials: D
authors.lastname: Grimm
authors.forename: Fabian
authors.initials: F
authors.lastname: Trillsch
authors.forename: Stefan
authors.initials: S
authors.lastname: Prieske
authors.forename: Gunhild
authors.initials: G
authors.lastname: von Amsberg
authors.forename: Cordula
authors.initials: C
authors.lastname: Petersen
authors.forename: Volkmar
authors.initials: V
authors.lastname: Mueller
authors.forename: Fritz
authors.initials: F
authors.lastname: Jaenicke
authors.forename: Linn
authors.initials: L
authors.lastname: Woelber
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D014846:Vulvar Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*
keywords: chemotherapy; metastatic; neoadjuvant; targeted treatment; vulvar cancer