title: Impaired sleep-associated modulation of post-exercise corticomotor depression in multiple sclerosis.
abstract: OBJECTIVE
  To compare the beneficial effect of nap versus rest on the recovery of motor evoked potentials (MEPs) after a fatiguing exercise performed in patients with multiple sclerosis (MS) and healthy controls.
  
  
  METHODS
  In 12 MS patients and 12 healthy controls, MEPs were recorded from the adductor pollicis muscle before, 10 and 60 min (T0, T10, and T60) after an effort of thumb adduction at 25% of maximal voluntary contraction force for 24 min. After the effort, the subject was maintained at rest or invited to have a nap while monitored with polysomnography. The two sessions (nap and rest) were randomly performed in each subject during the same day. The impact of nap and rest on post-exercise changes in MEP amplitude were studied in each group (patients and controls) and then compared between the two groups.
  
  
  RESULTS
  Although MEP amplitude at baseline was lower in MS patients than in controls, post-exercise corticomotor depression (PECD), expressed as T10/T0 MEP amplitude ratio, was similar in both groups. Regarding MEP amplitude recovery at T60, nap was significantly more beneficial than rest in healthy subjects, but not in MS patients.
  
  
  CONCLUSIONS
  Motor recovery from PECD following a fatiguing exercise can be enhanced by sleep (at least a short nap) in healthy subjects. In MS patients, sleep restorative effect is reduced or lost, maybe contributing to the excessive fatigue or fatigability characterized in these patients.
authors.affiliation: Université Paris Est Créteil, Faculté de Médecine, EA 4391, Créteil F-94010, France; AP-HP, Groupe Henri Mondor, Service de Physiologie, Explorations Fonctionnelles, Créteil F-94010, France. Electronic address: agathe.bridoux@hmn.aphp.fr.
authors.forename: Agathe
authors.initials: A
authors.lastname: Bridoux
authors.affiliation: Université Paris Est Créteil, Faculté de Médecine, EA 4391, Créteil F-94010, France; AP-HP, Groupe Henri Mondor, Service de Neurologie, Créteil F-94010, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Créange
authors.affiliation: AP-HP, Groupe Henri Mondor, Service de Physiologie, Explorations Fonctionnelles, Créteil F-94010, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Sangare
authors.affiliation: Université Paris Est Créteil, Faculté de Médecine, EA 4391, Créteil F-94010, France; AP-HP, Groupe Henri Mondor, Service de Physiologie, Explorations Fonctionnelles, Créteil F-94010, France.
authors.forename: Samar S
authors.initials: SS
authors.lastname: Ayache
authors.affiliation: Université Paris Est Créteil, Faculté de Médecine, EA 4391, Créteil F-94010, France; AP-HP, Groupe Henri Mondor, Service de Neurologie, Créteil F-94010, France.
authors.forename: Hassan
authors.initials: H
authors.lastname: Hosseini
authors.affiliation: Université Paris Est Créteil, Faculté de Médecine, EA 4391, Créteil F-94010, France; AP-HP, Groupe Henri Mondor, Service de Physiologie, Explorations Fonctionnelles, Créteil F-94010, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Drouot
authors.affiliation: Université Paris Est Créteil, Faculté de Médecine, EA 4391, Créteil F-94010, France; AP-HP, Groupe Henri Mondor, Service de Physiologie, Explorations Fonctionnelles, Créteil F-94010, France.
authors.forename: Jean-Pascal
authors.initials: JP
authors.lastname: Lefaucheur
mesh_terms: D000328:Adult; D013181:Cortical Spreading Depression / Q000502:physiology*; D019054:Evoked Potentials, Motor / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000503:physiopathology*; D012890:Sleep / Q000502:physiology*
keywords: Exercise; Fatigue; Motor evoked potentials; Multiple sclerosis; Polysomnography; Sleep