title: GWA meta-analysis of personality in Korean cohorts.
abstract: Personality is a determinant of behavior and lifestyle that is associated with health and human diseases. Despite the heritability of personality traits is well established, the understanding of the genetic contribution to personality trait variation is extremely limited. To identify genetic variants associated with each of the five dimensions of personality, we performed a genome-wide association (GWA) meta-analysis of three cohorts, followed by comparison of a family cohort. Personality traits were measured with the Revised NEO Personality Inventory for the five-factor model (FFM) of personality. We investigated the top five single-nucleotide polymorphisms (SNPs) for each trait, and revealed the most highly association with neuroticism and TACC2 (rs1010657, P=8.79 × 10(-7)), extraversion and PTPN12 (rs12537271, P=1.47 × 10(-7)), openness and IMPAD1 (rs16921695, P=5 × 10(-8)), agreeableness and RPS29 (rs8015351, P=1.27 × 10(-6)) and conscientiousness and LMO4 (rs912765, P=2.91 × 10(-6)). It had no SNP reached the GWA study threshold (P<5 × 10(-8)). When expanded the SNPs up to top 100, the correlation of PTPRD (rs1029089) and agreeableness was confirmed in Healthy Twin cohort with other 13 SNPs. This GWA meta-analysis on FFM personality traits is meaningful as it was the first on a non-Caucasian population targeted to FFM of personality traits.
authors.affiliation: Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Bo-Hye
authors.initials: BH
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Han-Na
authors.initials: HN
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Seung-Ju
authors.initials: SJ
authors.lastname: Roh
authors.affiliation: Complex Disease and Genetic Epidemiology Branch, Department of Epidemiology and Institute of Environment and Health, School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.affiliation: Complex Disease and Genetic Epidemiology Branch, Department of Epidemiology and Institute of Environment and Health, School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Sarah
authors.initials: S
authors.lastname: Yang
authors.affiliation: Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors.forename: Seung Ku
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Yeon-Ah
authors.initials: YA
authors.lastname: Sung
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Chung
authors.affiliation: Department of Preventive Medicine, School of Medicine, Ajou University, Suwon, Republic of Korea.
authors.forename: Nam H
authors.initials: NH
authors.lastname: Cho
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Korea University Hospital, Ansan, Republic of Korea.
authors.forename: Chol
authors.initials: C
authors.lastname: Shin
authors.affiliation: Complex Disease and Genetic Epidemiology Branch, Department of Epidemiology and Institute of Environment and Health, School of Public Health, Seoul National University, Seoul, Republic of Korea.
authors.forename: Joohon
authors.initials: J
authors.lastname: Sung
authors.affiliation: Department of Biochemistry, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Hyung-Lae
authors.initials: HL
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea / Q000453:epidemiology