title: High rate of nickel allergy in women with endometriosis: a 3-year population-based study.
abstract: OBJECTIVE
  The aim of this study was to evaluate the prevalence rates of nickel allergy, contact dermatitis, drug allergy, allergic rhinitis and atopic dermatitis among women with and without endometriosis.
  
  
  METHODS
  Data were obtained from the National Patient Sample of the Republic of Korea, which was provided by the Korean Health Insurance Review and Assessment Service. We evaluated women aged 20-40 years who visited a health care institution from 2009-2011. We estimated the prevalence of allergic diseases among women with and without endometriosis.
  
  
  RESULTS
  We extracted a sample of 1 843 447 women from the total patient sample of approximately 3 million. We identified 7259 women with endometriosis and 535 818 women without endometriosis. After adjusting for age and data year, the women with endometriosis had higher rates of nickel allergy (odds ratio = 1.175; 95% confidence interval, 1.011-1.366; P = 0.04). Additionally, after adjusting for age, data year and other allergic diseases, the women with endometriosis had higher rates of nickel allergy (odds ratio = 1.167; 95% confidence interval, 1.004-1.357; P = 0.04). After adjusting for other covariates, we found that other allergic disorders, such as allergic rhinitis, atopic dermatitis and contact dermatitis, were not associated with endometriosis.
  
  
  CONCLUSIONS
  Women with endometriosis had higher rates of nickel allergy. Further research is required to clarify the relation between nickel allergy and endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Eulji University, Daejeon, Republic of Korea.|Department of Obstetrics and Gynecology, Miz Medi Hospital, Seoul, Republic of Korea.
authors.forename: Jin-Sung
authors.initials: JS
authors.lastname: Yuk
authors.affiliation: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Yong Jin
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Kyong-Wook
authors.initials: KW
authors.lastname: Yi
authors.affiliation: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Kim
authors.initials: K
authors.lastname: Tak
authors.affiliation: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jun-Young
authors.initials: JY
authors.lastname: Hur
authors.affiliation: Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jung-Ho
authors.initials: JH
authors.lastname: Shin
mesh_terms: D000328:Adult; D003877:Dermatitis, Contact / Q000453:epidemiology; D004715:Endometriosis / Q000276:immunology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D009532:Nickel; D065631:Rhinitis, Allergic / Q000453:epidemiology
chemical_list: D009532:Nickel
keywords: allergy; endometriosis; nickel; prevalence