title: Unified Approach to Isoindolinones and THIQs via Lewis Acid Catalyzed Domino Mukaiyama-Mannich Lactamization/Alkylations: Application in the Synthesis of (±)-Homolaudanosine.
abstract: A novel and efficient synthesis of a variety of isoindolinones and tetrahydroisoquinolines via a Lewis acid catalyzed domino Mukaiyama-Mannich lactamization/alkylation is achieved. This transformation comprises a sequential formation of three new bonds through a one-pot, three-component procedure to afford product in moderate to high yields. A concise synthesis of (±)-homolaudanosine (2b) has been achieved using this method.
authors.affiliation: §Department of Chemistry, Indian Institute of Technology, Kanpur, UP 208 016, India.
authors.forename: Sivasankaran
authors.initials: S
authors.lastname: Dhanasekaran
authors.affiliation: †Department of Chemistry, Indian Institute of Science Education and Research, Bhopal, MP 462 066, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Kayet
authors.affiliation: †Department of Chemistry, Indian Institute of Science Education and Research, Bhopal, MP 462 066, India.
authors.forename: Arun
authors.initials: A
authors.lastname: Suneja
authors.affiliation: †Department of Chemistry, Indian Institute of Science Education and Research, Bhopal, MP 462 066, India.
authors.forename: Vishnumaya
authors.initials: V
authors.lastname: Bisai
authors.affiliation: †Department of Chemistry, Indian Institute of Science Education and Research, Bhopal, MP 462 066, India.|§Department of Chemistry, Indian Institute of Technology, Kanpur, UP 208 016, India.
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Singh
mesh_terms: D000478:Alkylation; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D007211:Indoles; D007546:Isoquinolines; D058116:Lewis Acids; C001522:laudanosine