title: Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer.
abstract: Pancreatic ductal adenocarcinoma (PDA) is a highly chemoresistant and metastatic disease with a dismal 5-year survival rate of 6%. More effective therapeutic targets and approaches are urgently needed to tackle this devastating disease. The base excision repair (BER) pathway has been identified as a predictor of therapeutic response, prognostic factor, and therapeutic target in a variety of cancers. This review will discuss our current understanding of BER in PDA and its potential to improve PDA treatment.
authors.affiliation: Pancreatic Cancer Translational Research Group, Lowy Cancer Research Centre, Prince of Wales Clinical School, UNSW Australia , Sydney, NSW , Australia.
authors.forename: George
authors.initials: G
authors.lastname: Sharbeen
authors.affiliation: Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Australia , Sydney, NSW , Australia.
authors.forename: Joshua
authors.initials: J
authors.lastname: McCarroll
authors.affiliation: Pancreatic Cancer Translational Research Group, Lowy Cancer Research Centre, Prince of Wales Clinical School, UNSW Australia , Sydney, NSW , Australia.
authors.forename: David
authors.initials: D
authors.lastname: Goldstein
authors.affiliation: Pancreatic Cancer Translational Research Group, Lowy Cancer Research Centre, Prince of Wales Clinical School, UNSW Australia , Sydney, NSW , Australia.
authors.forename: Phoebe A
authors.initials: PA
authors.lastname: Phillips
keywords: base excision repair; chemoresistance; pancreatic cancer; prognostic factors; therapeutic targets