title: Which are important targets in development of S. aureus mastitis vaccine?
abstract: Staphylococcus aureus represents one of the leading causes of mastitis in dairy cows worldwide. S. aureus IMI have variable outcomes due to virulence of the strain involved, immune defenses of the host, and by antibiotic resistance. The difficulty in eradication and the increasing concerns on antibiotics usages underscore the interest in developing new tools to control S. aureus mastitis. Vaccination represents one of the most studied of these tools but, so far, no vaccine seems to provide reliable protection. This review summarizes current knowledge on the major vaccine targets, including surface proteins, capsular polysaccharides, biofilm, and toxins. Finally, the present status of vaccination against S. aureus and the future of vaccine design were discussed, including how differences among in vivo models may influence vaccines development.
authors.affiliation: Dept. Veterinary Sciences and Public Health, Università degli Studi di Milano, Milano, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Scali
authors.affiliation: E.E.A. Rafaela, INTA, Santa Fe, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina.
authors.forename: C
authors.initials: C
authors.lastname: Camussone
authors.affiliation: E.E.A. Rafaela, INTA, Santa Fe, Argentina; Facultad de Ciencias Veterinarias, Universidad Nacional del Litoral, Esperanza, Santa Fe, Argentina.
authors.forename: L F
authors.initials: LF
authors.lastname: Calvinho
authors.affiliation: Dept. Veterinary Sciences and Public Health, Università degli Studi di Milano, Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cipolla
authors.affiliation: Dept. Veterinary Sciences and Public Health, Università degli Studi di Milano, Milano, Italy. Electronic address: zecconiconsult@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Zecconi
mesh_terms: D000818:Animals; D002417:Cattle; D005260:Female; D008414:Mastitis, Bovine / Q000382:microbiology / Q000517:prevention & control*; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D013209:Staphylococcal Vaccines / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*; D037521:Virulence Factors / Q000276:immunology*
chemical_list: D013209:Staphylococcal Vaccines; D037521:Virulence Factors
keywords: Immune response; Mastitis; Staphylococcus aureus; Vaccine; Virulence factors