title: Efficacy of Sublingual Immunotherapy with Dermatophagoides farinae Extract in Monosensitized and Polysensitized Patients with Allergic Rhinitis: Clinical Observation and Analysis.
abstract: OBJECTIVE
  To investigate differences in the efficacy of sublingual immunotherapy with Dermatophagoides farinae drops in monosensitized and polysensitized allergic rhinitis patients.
  
  
  METHODS
  The patients enrolled in the study were treated for more than one year by sublingual immunotherapy (SLIT) using Dermatophagoides farinae drops and were divided into a monosensitized group (n = 20) and a polysensitized group (n = 30). Total nasal symptom scores of patients before and after SLIT were analyzed to evaluate the curative effect. The phylogenetic tree of dust mite allergens as well as other allergens that were tested by skin prick test was constructed to help the analysis.
  
  
  RESULTS
  There was no significant difference in the efficacy of SLIT between dust mite monosensitized and polysensitized patients.
  
  
  CONCLUSIONS
  Both dust mite monosensitized and polysensitized patients could be cured by SLIT using Dermatophagoides farinae drops. This study provides a reference for the selection of allergens to be used in immunotherapy for polysensitized AR patients.
authors.affiliation: Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang Road East, Guangzhou 510260, China.
authors.forename: Chen-Xia
authors.initials: CX
authors.lastname: Xu
authors.affiliation: Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang Road East, Guangzhou 510260, China.
authors.forename: Miao-Lian
authors.initials: ML
authors.lastname: Zhang
authors.affiliation: Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang Road East, Guangzhou 510260, China.
authors.forename: Bi-Zhou
authors.initials: BZ
authors.lastname: Li
authors.affiliation: Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang Road East, Guangzhou 510260, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: He
authors.affiliation: Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang Road East, Guangzhou 510260, China.
authors.forename: Ze-Hong
authors.initials: ZH
authors.lastname: Zou
authors.affiliation: Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang Road East, Guangzhou 510260, China.
authors.forename: Qiu-Rong
authors.initials: QR
authors.lastname: Wu
authors.affiliation: Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang Road East, Guangzhou 510260, China.
authors.forename: Ai-Lin
authors.initials: AL
authors.lastname: Tao
authors.affiliation: Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, The State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital of Guangzhou Medical University, 250 Changgang Road East, Guangzhou 510260, China.
authors.forename: He
authors.initials: H
authors.lastname: Lai
authors.affiliation: Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1, Shuai Fu Yuan, East District, Beijing 100730, China.
authors.forename: Jin-Lu
authors.initials: JL
authors.lastname: Sun
mesh_terms: D000818:Animals; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D040001:Dermatophagoides farinae / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007114:Immunization; D010802:Phylogeny; D065631:Rhinitis, Allergic / Q000276:immunology* / Q000628:therapy*; D012882:Skin Tests; D063729:Sublingual Immunotherapy; D016896:Treatment Outcome
chemical_list: D039741:Antigens, Dermatophagoides