title: Preclinical study of a novel hydrodynamically levitated centrifugal pump for long-term cardiopulmonary support : In vivo performance during percutaneous cardiopulmonary support.
abstract: An extracorporeal centrifugal blood pump with a hydrodynamically levitated impeller was developed for use in a durable extracorporeal membrane oxygenation (ECMO) system. The present study examined the biocompatibility of the blood pump during long-term use by conducting a series of 30-day chronic animal experiments. The ECMO system was used to produce a percutaneous venoarterial bypass between the venae cavae and carotid artery in adult goats. No anticoagulation or antiplatelet therapy was administered during the experiments. Three out of four animals survived for the scheduled 30-day period, and the blood pumps and membrane oxygenators both exhibited sufficient hydrodynamic performance and good antithrombogenicity, while one animal died of massive bleeding from the outflow cannulation site. The animals' plasma free hemoglobin had returned to within the normal range by 1 week after the surgical intervention, and their hemodynamic and biochemistry parameters remained within their normal ranges throughout the experiment. The explanted centrifugal blood pumps did not display any trace of thrombus formation. Based on the biocompatibility demonstrated in this study, the examined centrifugal blood pump, which includes a hydrodynamically levitated impeller, is suitable for use in durable ECMO systems.
authors.affiliation: Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka, 5658565, Japan. tsukiya@ncvc.go.jp.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Tsukiya
authors.affiliation: Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka, 5658565, Japan. toshi@ncvc.go.jp.
authors.forename: Toshihide
authors.initials: T
authors.lastname: Mizuno
authors.affiliation: Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka, 5658565, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takewa
authors.affiliation: Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka, 5658565, Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Tatsumi
authors.affiliation: Department of Artificial Organs, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka, 5658565, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Taenaka
mesh_terms: D000818:Animals; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D006041:Goats; D006439:Hemodynamics; D057446:Hydrodynamics; D008422:Materials Testing; D010107:Oxygenators, Membrane
keywords: Animal experiment; Centrifugal pump; ECMO; Hydrodynamic levitation