title: Comparison of nanoparticle penetration into solid tumors and sites of inflammation: studies using targeted and nontargeted liposomes.
abstract: OBJECTIVE
  The vast majority of nanomedicine research is focused on the use of nanoparticles for the diagnosis and treatment of cancer. However, the dense extracellular matrix of solid tumors restricts nanoparticle penetration, raising the question of whether the best applications of nanomedicines lie in oncology.
  
  
  METHODS
  In this study, the uptake of folate-conjugated liposomes was compared between folate receptor-expressing tumors and folate receptor+ inflammatory lesions within the same mouse.
  
  
  RESULTS
  We demonstrate here that both folate-targeted and nontargeted liposomes accumulate more readily at sites of inflammation than in solid tumors.
  
  
  CONCLUSIONS
  These data suggest that nanosized imaging and therapeutic agents may be better suited for the treatment and diagnosis of inflammatory/autoimmune diseases than cancer.
authors.affiliation: 1Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.|2Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Poh
authors.affiliation: 1Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.|3Department of Chemistry, Indian Institute of Technology Indore, Madhya Pradesh, Indore 452017, India.
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Chelvam
authors.affiliation: 1Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Philip S
authors.initials: PS
authors.lastname: Low
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000378:metabolism; D016503:Drug Delivery Systems; D005492:Folic Acid / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D053758:Nanoparticles / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D008081:Liposomes; D005492:Folic Acid
keywords: cancer; folate; inflammation; liposome; nanomedicine; nanoparticle