title: FcγR dependent mechanisms of cytotoxic, agonistic, and neutralizing antibody activities.
abstract: Given the widespread use of antibodies of the immunoglobulin G (IgG) class as cytotoxic, immunomodulatory, and neutralizing agents in the therapy of malignant, infectious, and autoimmune diseases, understanding the molecular and cellular mechanisms responsible for their therapeutic activity is of major importance. While Fcγ receptors (FcγR) have well-appreciated roles as effectors of cytotoxic IgG activity, it has only recently become clear that the functionality of immunomodulatory and neutralizing IgG preparations also depends on cellular FcγRs. Here, we review current models of IgG activity in infectious and inflammatory settings, and examine the importance of cell type-specific expression of FcγRs in determining functional outcome. We discuss how this knowledge may be used to improve the activity of therapeutic antibody preparations and outline important areas of focus for future research.
authors.affiliation: Institute of Genetics at the Department of Biology, Friedrich-Alexander University Erlangen-Nürnberg, Erwin-Rommelstrasse 3, 91058 Erlangen, Germany. Electronic address: falk.nimmerjahn@fau.de.
authors.forename: Falk
authors.initials: F
authors.lastname: Nimmerjahn
authors.affiliation: Institute of Genetics at the Department of Biology, Friedrich-Alexander University Erlangen-Nürnberg, Erwin-Rommelstrasse 3, 91058 Erlangen, Germany.
authors.forename: Sina
authors.initials: S
authors.lastname: Gordan
authors.affiliation: Institute of Genetics at the Department of Biology, Friedrich-Alexander University Erlangen-Nürnberg, Erwin-Rommelstrasse 3, 91058 Erlangen, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Lux
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D003141:Communicable Diseases / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D018448:Models, Immunological; D017452:Receptors, IgG / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D007074:Immunoglobulin G; D017452:Receptors, IgG
keywords: Fc receptor; agonistic antibody; cytotoxicity; immunoglobulin G; neutralizing antibody