title: Human Herpesvirus 8-Related Primary Effusion Lymphoma After Liver Transplantation.
abstract: Primary effusion lymphoma is a rare subclass of non-Hodgkin lymphoma associated with human herpesvirus 8 infection and principally seen in human immunodeficiency virus-positive patients. We report on the case of a 72-year-old human immunodeficiency virus-negative male with a hepatic transplant 10 years prior, who presented with a symptomatic right-sided pleural effusion and was found to have primary effusion lymphoma by flow cytometric and cytopathologic examination. Immunohistochemistry of his lymphoma cells was positive for human herpesvirus 8. Both he and his donor had no identifiable risk factors for human herpesvirus 8 infection. The patient was intolerant of antiviral therapy and chemotherapy, dying 7 months after diagnosis. Posttransplant primary effusion lymphoma is exceedingly rare and carries a very poor prognosis. Individualized treatment strategies are necessary given the scant body of published literature with guidance based solely on case reports.
authors.affiliation: Department of Medicine, Johns Hopkins University, Baltimore, MD.
authors.forename: E S
authors.initials: ES
authors.lastname: Christenson
authors.affiliation: Department of Oncology, Johns Hopkins University, Baltimore, MD.
authors.forename: B
authors.initials: B
authors.lastname: Teply
authors.affiliation: Department of Medicine, Johns Hopkins University, Baltimore, MD.
authors.forename: V
authors.initials: V
authors.lastname: Agrawal
authors.affiliation: Department of Pathology, Johns Hopkins University, Baltimore, MD.
authors.forename: P
authors.initials: P
authors.lastname: Illei
authors.affiliation: Department of Medicine, Johns Hopkins University, Baltimore, MD.
authors.forename: A
authors.initials: A
authors.lastname: Gurakar
authors.affiliation: Department of Medicine, Johns Hopkins University, Baltimore, MD.
authors.forename: J A
authors.initials: JA
authors.lastname: Kanakry
mesh_terms: D000368:Aged; D006566:Herpesviridae Infections / Q000150:complications* / Q000175:diagnosis; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D016031:Liver Transplantation; D054685:Lymphoma, Primary Effusion / Q000175:diagnosis / Q000821:virology*; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis / Q000821:virology*
keywords: Antibiotic: antiviral; cancer/malignancy/neoplasia: hematogenous/leukemia/lymphoma; complication: infectious; complication: malignant, infection and infectious agents; viral: human herpes virus 8 (HHV-8)