title: [Heritability of body mass index on Chinese adult twins from nine provinces/cities in China].
abstract: OBJECTIVE
  To explore the heritability of body mass index (BMI) in twins across different regions and genders in China.
  
  
  METHODS
  A total of 11 122 adult twin pairs from the Chinese National Twin Registry were interviewed. A structural equation model was used to estimate the heritability of BMI.
  
  
  RESULTS
  This study included 6 226 monozygotic twin pairs and 4 896 dizygotic twin pairs, with the age range as 25-85 (39.0 ± 10.8) years. Under stratified analysis by region, results showed that the highest and lowest rates on heritability of BMI in men were seen in Tianjin and Zhejiang, as 67.8% (95% CI: 50.1%-85.8%) and 42.1% (95% CI: 27.2%-60.9%), while in women were seen in Sichuan and Heilongjiang as 56.2% (95% CI: 47.5%-70.0%) and 11.2% (95% CI: 0.0%-31.7%), respectively. Results from the stratified analysis showed that, by gender, the heritability of BMI in men was higher than that in women from the same region. The biggest differences of heritability of BMI between men and women were seen in Heilongjiang as 55.3% (95% CI: 35.5%-80.0%) and 11.2% (95% CI: 0-31.7%), while the smallest differences were seen in Sichuan as 61.5% (95% CI: 40.7%-86.4%) and 56.2% (95% CI: 47.5%-70.0%), respectively.
  
  
  CONCLUSIONS
  The heritability of BMI across different regions and genders showed certain differences in the Chinese twins.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 10019.
authors.forename: Liming
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 10019.
authors.forename: Jun
authors.initials: J
authors.lastname: Lyu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 10019.
authors.forename: Canqing
authors.initials: C
authors.lastname: Yu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 10019.
authors.forename: Shengfeng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Qingdao Center for Disease Control and Prevention, Shandong.
authors.forename: Zengchang
authors.initials: Z
authors.lastname: Pang
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention.
authors.forename: Liming
authors.initials: L
authors.lastname: Cong
authors.affiliation: Beijing Center for Disease Control and Prevention.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Shanghai Center for Disease Control and Prevention.
authors.forename: Fan
authors.initials: F
authors.lastname: Wu
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention.
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.affiliation: Sichuan Provincial Center for Disease Control and Prevention.
authors.forename: Xianping
authors.initials: X
authors.lastname: Wu
authors.affiliation: Tianjin Center for Disease Control and Prevention.
authors.forename: Guohong
authors.initials: G
authors.lastname: Jiang
authors.affiliation: Qinghai Provincial Center for Disease Control and Prevention.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Wang
authors.affiliation: Harbin Medical University.
authors.forename: Binyou
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Gao
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Email: caoweihua60@163.com.
authors.forename: Weihua
authors.initials: W
authors.lastname: Cao
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D002681:China; D002947:Cities; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012042:Registries; D014429:Twins, Dizygotic / Q000235:genetics* / Q000706:statistics & numerical data; D014430:Twins, Monozygotic / Q000235:genetics* / Q000706:statistics & numerical data