title: Atrial and ventricular arrhythmias in hypertrophic cardiomyopathy.
abstract: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease caused by mutations in genes coding for cardiac sarcomeres. HCM is the most common inherited heart disease, with a prevalence of 0.2%. There are multiple genetic variants that cause pleomorphic clinical attributes and disease characterized by myocardial disarray and myocardial hypertrophy. Patients are at an increased risk of atrial and ventricular arrhythmias. Management of these arrhythmias is complex. Atrial fibrillation is associated with increased mortality and thromboembolism. Ventricular arrhythmias are life threatening and best treated with an implantable defibrillator.
authors.affiliation: Department of Cardiology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.
authors.forename: Kartik R
authors.initials: KR
authors.lastname: Kumar
authors.affiliation: Department of Cardiology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.
authors.forename: Swati N
authors.initials: SN
authors.lastname: Mandleywala
authors.affiliation: Department of Cardiology, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA. Electronic address: MLink@tuftsmedicalcenter.org.
authors.forename: Mark S
authors.initials: MS
authors.lastname: Link
mesh_terms: D001145:Arrhythmias, Cardiac; D002312:Cardiomyopathy, Hypertrophic; D004562:Electrocardiography; D006801:Humans; D012307:Risk Factors
keywords: Arrhythmias; Atrial fibrillation; Electrophysiology; Hypertrophic cardiomyopathy; Risk factors; Ventricular fibrillation