title: In-vivo iMap IVUS comparison of in-stent neointima and native coronary atherosclerosis.
abstract: OBJECTIVE
  The purpose of this study was to compare plaque characteristics of native coronary atherosclerosis and in-stent neointima ten months after ST elevation myocardial infarction (STEMI) using iMap intravascular ultrasound (IVUS).
  
  
  METHODS
  In 49 patients in-stent neointima and the coronary segment proximal to the stent were analyzed with iMap intravascular ultrasound (IVUS) ten months after primary PCI for STEMI.
  
  
  RESULTS
  A higher percentage of necrotic tissue was observed in the proximal coronary segment compared to the in-stent neointima by iMap IVUS (25.5% ± 12.8% vs 12.3% ± 3.3%, p < 0.0001) ten months after STEMI. The proportion of fibrotic tissue in the proximal segment was lower (63.6% ± 14.8% vs 72.0% ± 5.7%, p = 0.002) and the proportion of the lipidic tissue was higher (8.8% ± 3.0% vs 5.9% ± 2.0%, p < 0.0001) than in-stent neointima.
  
  
  CONCLUSIONS
  In patients ten months after STEMI, in-stent neointima contained a higher proportion of fibrotic tissue and lower proportion of necrotic and lipidic tissue compared the native atherosclerotic lesion.
authors.affiliation: Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Riga, Latvia; Faculty of Medicine, Riga Stradins University, Riga, Latvia. Electronic address: cardio@inbox.lv.
authors.forename: Karlis
authors.initials: K
authors.lastname: Trusinskis
authors.affiliation: Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Riga, Latvia. Electronic address: karlis.strenge@gmail.com.
authors.forename: Karlis
authors.initials: K
authors.lastname: Strenge
authors.affiliation: Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Riga, Latvia.
authors.forename: Dace
authors.initials: D
authors.lastname: Juhnevica
authors.affiliation: Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Riga, Latvia.
authors.forename: Andrejs
authors.initials: A
authors.lastname: Erglis
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging; D058426:Neointima / Q000000981:diagnostic imaging*; D062645:Percutaneous Coronary Intervention; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000473:pathology; D015607:Stents; D018084:Ultrasonography, Interventional / Q000379:methods
keywords: iMap IVUS; neointima; tissue characterization