title: Epidemiology and genetic characterization of measles strains in Senegal, 2004-2013.
abstract: BACKGROUND
  In Senegal, with the variable routine vaccination coverage, the risk for illness and death from measles still exists as evidenced by the measles epidemic episode in 2009. Since 2002 a laboratory-based surveillance system of measles was established by the Ministry of Health and the Institut Pasteur de Dakar. The present study analysed the data collected over the 10 years inclusive between 2004-2013 in order to define a measles epidemiological profile in Senegal, and we carried out a phylogenetic analysis of measles virus circulating in Senegal over the period 2009-2012.
  
  
  RESULTS
  A total number of 4580 samples were collected from suspected cases, with the most cases between 2008 and 2010 (2219/4580; 48.4%). The majority of suspected cases are found in children from 4-6 years old (29%). 981 (21.4%) were measles laboratory-confirmed by IgM ELISA. The measles confirmation rate per year is very high during 2009-2010 periods (48.5% for each year). Regarding age groups, the highest measles IgM-positivity rate occurred among persons aged over 15 years with 39.4% (115/292) followed by 2-3 years old age group with 30.4% (323/1062) and 30% (148/494) in children under one year old group. The majority of suspected cases were collected between February and June and paradoxically confirmed cases rates increased from July (77/270; 28.6%) and reached a peak in November with 60% (93/155). Phylogenetic analysis showed that all the 29 sequences from strains that circulated in Senegal between 2009 and 2012 belong to the B3 genotype and they are clustered in B3.1 (2011-2012) and B3.3 (2009-2011) sub-genotypes according to a temporal parameter.
  
  
  CONCLUSIONS
  Improvements in the measles surveillance in Senegal are required and the introduction of oral fluid and FTA cards as an alternative to transportation of sera should be investigated to improve surveillance. The introduction of a national vaccine database including number of doses of measles-containing vaccine will greatly improve efforts to interrupt and ultimately eliminate measles virus transmission in Senegal.
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: Ndongo
authors.initials: N
authors.lastname: Dia
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: Ameth
authors.initials: A
authors.lastname: Fall
authors.affiliation: Laboratoire de Bactériologie, Centre Hospitalier National Universitaire de Fann, Dakar, Sénégal.
authors.forename: Rouguiyatou
authors.initials: R
authors.lastname: Ka
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: Amary
authors.initials: A
authors.lastname: Fall
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: David E
authors.initials: DE
authors.lastname: Kiori
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: Deborah G
authors.initials: DG
authors.lastname: Goudiaby
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: Aichatou D
authors.initials: AD
authors.lastname: Fall
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: El Hadj Abdourahmane
authors.initials: el HA
authors.lastname: Faye
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: Annick
authors.initials: A
authors.lastname: Dosseh
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: Kader
authors.initials: K
authors.lastname: Ndiaye
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: Ousmane M
authors.initials: OM
authors.lastname: Diop
authors.affiliation: Institut Pasteur de Dakar, Unité de Virologie Médicale, Dakar, Sénégal.
authors.forename: Mbayame Nd
authors.initials: MN
authors.lastname: Niang
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008457:Measles / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D008458:Measles Vaccine / Q000008:administration & dosage; D008459:Measles virus / Q000235:genetics; D012675:Senegal / Q000453:epidemiology
chemical_list: D008458:Measles Vaccine