title: Controlled delivery of the popular nonsteroidal anti-inflammatory drug, paracetamol, from chitosan-g-polyacrylamide microspheres prepared by the emulsion crosslinking technique.
abstract: In this paper, chitosan-graft-polyacrylamide (CS-g-PAAm) microspheres as drug delivery matrices of paracetamol were prepared by the emulsion crosslinking technique, using glutaraldehyde (GA) as a crosslinker. Graft copolymer of chitosan with acrylamide was synthesized using cerium (IV) ammonium nitrate (CAN). The microspheres formed had average particle sizes in the range of 78-252 μm. Paracetamol entrapment efficiency was found to vary between 31.89% and 72.61%, as determined by UV spectroscopy. Drug release in acidic and phosphate buffer solutions (pH 1.2 and 7.4) of the CS-g-PAAm microspheres was influenced by formulation factors such as the concentration of CS-g-PAAm, the paracetamol/polymer ratio (w/w), and the amount of crosslinker.
authors.affiliation: a Department of Chemistry , Science and Arts Faculty, Afyon Kocatepe University , Afyonkarahisar , Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Bulut
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D000180:Acrylic Resins / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D004655:Emulsions; D008863:Microspheres; D010316:Particle Size; D000099166:Polyacrylamides
chemical_list: D000082:Acetaminophen; D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D048271:Chitosan; D003692:Delayed-Action Preparations; D004655:Emulsions; D000099166:Polyacrylamides
keywords: chitosan; controlled release; graft copolymerization; microspheres; paracetamol