title: The MARK-AGE extended database: data integration and pre-processing.
abstract: MARK-AGE is a recently completed European population study, where bioanalytical and anthropometric data were collected from human subjects at a large scale. To facilitate data analysis and mathematical modelling, an extended database had to be constructed, integrating the data sources that were part of the project. This step involved checking, transformation and documentation of data. The success of downstream analysis mainly depends on the preparation and quality of the integrated data. Here, we present the pre-processing steps applied to the MARK-AGE data to ensure high quality and reliability in the MARK-AGE Extended Database. Various kinds of obstacles that arose during the project are highlighted and solutions are presented.
authors.affiliation: Chair of Molecular Toxicology, University of Konstanz, 78457 Konstanz, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Baur
authors.affiliation: Chair of Bioinformatics and Information Mining, University of Konstanz, 78457 Konstanz, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Kötter
authors.affiliation: Chair of Molecular Toxicology, University of Konstanz, 78457 Konstanz, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Moreno-Villanueva
authors.affiliation: Chair of Molecular Toxicology, University of Konstanz, 78457 Konstanz, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Sindlinger
authors.affiliation: Chair of Bioinformatics and Information Mining, University of Konstanz, 78457 Konstanz, Germany.
authors.forename: M R
authors.initials: MR
authors.lastname: Berthold
authors.affiliation: Chair of Molecular Toxicology, University of Konstanz, 78457 Konstanz, Germany. Electronic address: alexander.buerkle@uni-konstanz.de.
authors.forename: A
authors.initials: A
authors.lastname: Bürkle
authors.affiliation: Department of Mathematics and Statistics, University of Konstanz, 78457 Konstanz, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Junk
mesh_terms: D000375:Aging / Q000502:physiology*; D003219:Confidentiality; D016208:Databases, Factual; D005260:Female; D006801:Humans; D016247:Information Storage and Retrieval; D008297:Male
keywords: Data entry; Data extraction; Data integration; Data processing; Database; KNIME