title: Registered report: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs.
abstract: The Science in 2010 (Sugahara et al., 2010). The key experiments being replicated include Figure 2 and Supplemental Figure 9A. In Figure 2, Sugahara and colleagues presented data on the tumor penetrance of doxorubicin (DOX) when co-administered with the peptide iRGD, as well as the effect of co-treatment of DOX and iRGD on tumor weight and cell death. In Supplemental Figure 9A, they tracked body weight of mice treated with DOX and iRGD to provide evidence that iRGD does not increase known DOX toxicity. The Reproducibility Project: Cancer Biology is a collaboration between the eLife.
authors.affiliation: Developmental Therapeutics Core, Northwestern University, Evanston, Illinois, United States.
authors.forename: Irawati
authors.initials: I
authors.lastname: Kandela
authors.affiliation: LifeTein, South Plainsfield, New Jersey, United States.
authors.forename: James
authors.initials: J
authors.lastname: Chou
authors.affiliation: Genentech, South San Francisco, California, United States.
authors.forename: Kartoa
authors.initials: K
authors.lastname: Chow
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D001692:Biological Transport; D057846:Cell-Penetrating Peptides / Q000378:metabolism / Q000493:pharmacokinetics*; D004317:Doxorubicin / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D004337:Drug Carriers / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009842:Oligopeptides / Q000378:metabolism / Q000493:pharmacokinetics*; D010539:Permeability; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016896:Treatment Outcome; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D000903:Antibiotics, Antineoplastic; D057846:Cell-Penetrating Peptides; D004337:Drug Carriers; C569656:N-end cysteine peptide tumor-homing peptide; D009842:Oligopeptides; D004317:Doxorubicin
keywords: Reproducibility Project: Cancer Biology; human; human biology; medicine; methodology; tumor penetrating peptide