title: Sedentary time in late childhood and cardiometabolic risk in adolescence.
abstract: OBJECTIVE
  There is a paucity of prospective evidence examining the links between sedentary time (ST) and cardiometabolic outcomes in youth. We examined the associations between objectively assessed ST and moderate to vigorous physical activity (MVPA) in childhood with cardiometabolic risk in adolescence.
  
  
  METHODS
  The study included 4639 children (47% male) aged 11 to 12 years at baseline whose mothers were enrolled in ALSPAC (Avon Longitudinal Study of Parents and Children) during their pregnancy in the early 1990s. A total of 2963 children had valid blood samples at age 15 to 16 years. Associations with baseline ST and MVPA were examined for BMI, waist circumference, body fat mass, lean body mass, systolic and diastolic blood pressure, fasting triglycerides, total cholesterol, low-density lipoprotein and high-density lipoprotein (HDL) cholesterol, glucose, insulin, C-reactive protein, and a clustered standardized cardiometabolic risk score (CMscore).
  
  
  RESULTS
  Baseline ST was not associated deleteriously with any cardiometabolic markers. MVPA was beneficially associated with the 3 adiposity indicators, lean body mass, systolic blood pressure, triglycerides, C-reactive protein, insulin, HDL cholesterol, and CMscore; once the models were adjusted for baseline levels of these markers, these associations remained for body fat mass (mean difference per 10 minutes of MVPA: -0.320 [95% confidence interval (CI): -0.438 to -0.203]; P < .001), HDL cholesterol (0.006 logged mmol/L [95% CI: 0.001 to 0.011]; P = .028), insulin (-0.024 logged IU/L [95% CI: -0.036 to -0.013]; P < .001), and CMscore (-0.014 [95% CI: -0.025 to -0.004]; P = .009).
  
  
  CONCLUSIONS
  We found no evidence linking ST in late childhood with adverse cardiometabolic outcomes in adolescence. Baseline MVPA was beneficially linked to broad cardiometabolic health in adolescence.
authors.affiliation: Charles Perkins Centre and Exercise and Sport Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia; PARG (Physical Activity Research Group), Department of Epidemiology and Public Health, University College London, London, United Kingdom; emmanuel.stamatakis@sydney.edu.au.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Stamatakis
authors.affiliation: PARG (Physical Activity Research Group), Department of Epidemiology and Public Health, University College London, London, United Kingdom; Division of Social Statistics and Demography, School of Social Sciences, University of Southampton, Southampton, United Kingdom;
authors.forename: Ngaire
authors.initials: N
authors.lastname: Coombs
authors.affiliation: School of Social and Community Medicine, MRC Integrative Epidemiology Unit, and.
authors.forename: Kate
authors.initials: K
authors.lastname: Tiling
authors.affiliation: UKCRC Centre for Diet and Activity Research (CEDAR) and MRC Epidemiology Unit, University of Cambridge, United Kingdom;
authors.forename: Calum
authors.initials: C
authors.lastname: Mattocks
authors.affiliation: Centre for Exercise, Nutrition, and Health Sciences, University of Bristol, Bristol, United Kingdom; National Institute for Health Research Bristol Biomedical Research Unit in Nutrition, Diet and Lifestyle, Bristol, United Kingdom; and.
authors.forename: Ashley
authors.initials: A
authors.lastname: Cooper
authors.affiliation: Charles Perkins Centre and Prevention Research Collaboration, Sydney School of Public Health, University of Sydney, Medical Foundation Building, Sydney NSW, Australia.
authors.forename: Louise L
authors.initials: LL
authors.lastname: Hardy
authors.affiliation: School of Social and Community Medicine, MRC Integrative Epidemiology Unit, and.
authors.forename: Debbie A
authors.initials: DA
authors.lastname: Lawlor
mesh_terms: D000293:Adolescent; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology*; D011446:Prospective Studies; D012307:Risk Factors; D057185:Sedentary Behavior