title: [Possibility of diagnostics of the non-steroidal anti-inflammatory drugs intolerance with a change in the chemiluminescent glow of the polymorphonuclear leukocytes of the peripheral blood].
abstract: We investigated the intensity of barium sulfate stimulated luminol-dependent chemiluminescence (SLCL) of pre-incubated blood with various concentrations of sodium salicylate, sodium metamizol or sodium diclofenac. Blood was received from healthy donors and patients with intolerance to aspirin and/or sodium metamizol and/or sodium diclofenac. Revealed valid differences in SLCL of blood received from healthy donors and patients with intolerance to these drugs allows us to use chemiluminescence method for the diagnosis of intolerance to non-steroidal anti-inflammatory drugs.
authors.forename: S V
authors.initials: SV
authors.lastname: Chausova
authors.forename: K G
authors.initials: KG
authors.lastname: Gurevich
authors.forename: G P
authors.initials: GP
authors.lastname: Bondareva
authors.forename: O Ju
authors.initials: OJ
authors.lastname: Filatov
authors.forename: I Y
authors.initials: IY
authors.lastname: Malyshev
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003627:Data Interpretation, Statistical; D004342:Drug Hypersensitivity / Q000097:blood*; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007958:Leukocyte Count; D008163:Luminescent Measurements; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal