title: Prognostic value of initial elevation in cardiac troponin I level in critically ill patients without acute coronary syndrome.
abstract: BACKGROUND
  Cardiac troponin I levels are often obtained to help rule out acute coronary syndrome.
  
  
  OBJECTIVE
  To determine if elevation of troponin level within 24 hours for patients without acute coronary syndrome admitted to the intensive care unit provides important prognostic information.
  
  
  METHODS
  Patients without acute coronary syndrome admitted to the intensive care unit were prospectively divided into 2 groups according to highest serum level of cardiac troponin I within 24 hours of admission (elevated > 0.049 ng/mL; control ≤ 0.049 ng/mL). Hospital mortality, incidence of intubation, and other parameters were compared between the 2 groups.
  
  
  RESULTS
  Patients with elevated troponin level (n = 40) had higher mortality than did control patients (n = 50) (35% vs 12%; P= .01). Compared with control patients, patients with elevated levels were more likely to be intubated (41% vs 17%; P= .02).
  
  
  CONCLUSIONS
  Critically ill patients without acute coronary syndrome with elevated levels of cardiac troponin I at admission had higher mortality and more intubations than did control patients.
authors.forename: Michael
authors.initials: M
authors.lastname: Liu
authors.forename: Merita
authors.initials: M
authors.lastname: Shehu
authors.forename: Edmund
authors.initials: E
authors.lastname: Herrold
authors.forename: Henry
authors.initials: H
authors.lastname: Cohen
mesh_terms: D054058:Acute Coronary Syndrome; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002423:Cause of Death; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000401:mortality* / Q000628:therapy; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D010343:Patient Admission; D011379:Prognosis; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D013997:Time Factors; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D019210:Troponin I