title: Internal dosimetry for intake of 18FDG using spot urine sample.
abstract: In nuclear medicine, workers handle unsealed radioactive materials. Among the materials, (18)FDG is the most widely used in PET/CT technique. Because of the short half-life of (18)F, it is very challenging to monitor internal exposure of nuclear medicine workers using in vitro bioassay. Thus, the authors developed the new in vitro bioassay methodology for short half-life nuclides. In the methodology, spot urine sample is directly used without normalisation to 1-d urine sample and the spot urinary excretion function was newly proposed. In order to estimate the intake and committed dose for workers dealing (18)FDG, biokinetic models for FDG was also developed. Using the new methodology and biokinetic model, the in vitro bioassay for workers dealing (18)FDG was successfully performed. The authors expect that this methodology will be very useful for internal monitoring of workers who deal short-lived radionuclides in the all field as well as the nuclear medicine field.
authors.affiliation: Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Korea.
authors.forename: Siwan
authors.initials: S
authors.lastname: Noh
authors.affiliation: Korea Atomic Energy Research Institute, 989-111 Daeduk-daero, Yuseong-gu, Daejeon 305-353, Korea.
authors.forename: Sol
authors.initials: S
authors.lastname: Jeong
authors.affiliation: National Institute of Environmental Research, 42 Hwangyeong-ro, Seo-gu, Incheon 404-708, Korea.
authors.forename: Mijeong
authors.initials: M
authors.lastname: An
authors.affiliation: Korean Association for Radiation Application, 77 Seongsuil-ro, Seongdong-gu, Seoul 133-822, Korea.
authors.forename: Han-Ki
authors.initials: HK
authors.lastname: Jang
authors.affiliation: Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Korea.
authors.forename: Tae-Eun
authors.initials: TE
authors.lastname: Kwon
authors.affiliation: Korea Atomic Energy Research Institute, 989-111 Daeduk-daero, Yuseong-gu, Daejeon 305-353, Korea.
authors.forename: Jong Il
authors.initials: JI
authors.lastname: Lee
authors.affiliation: Korean Association for Radiation Application, 77 Seongsuil-ro, Seongdong-gu, Seoul 133-822, Korea.
authors.forename: Tai Jin
authors.initials: TJ
authors.lastname: Park
authors.affiliation: Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 133-791, Korea jakilee@hanyang.ac.kr.
authors.forename: Jai-Ki
authors.initials: JK
authors.lastname: Lee
mesh_terms: D001681:Biological Assay; D019788:Fluorodeoxyglucose F18 / Q000652:urine*; D006801:Humans; D009683:Nuclear Medicine; D016273:Occupational Exposure / Q000032:analysis*; D011829:Radiation Dosage; D011834:Radiation Monitoring / Q000379:methods*; D019275:Radiopharmaceuticals / Q000652:urine*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18