title: Insights into Myeloid-Derived Suppressor Cells in Inflammatory Diseases.
abstract: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells involved in immune regulation. This population subdivides into granulocytic MDSCs and monocytic MDSCs, which regulate immune responses via the production of various molecules including reactive oxygen species, nitric oxide, arginase-1, interleukin-10, and transforming growth factor-β. Most studies of MDSCs focused on their role in tumors. MDSCs protect tumor cells from immune responses, and thus the frequency of MDSCs associates with poor prognosis. Many recent studies reported an important role for MDSCs in inflammatory diseases via the regulation of immune cells. In addition, the utilization of MDSCs by infectious pathogens suggests an immune evasion mechanism. Thus, MDSCs are important immune regulators in inflammatory diseases, as well as in tumors. This review focuses on the role of MDSCs in the regulation of inflammation in non-tumor settings.
authors.affiliation: School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, 500-712, Republic of Korea.
authors.forename: Yewon
authors.initials: Y
authors.lastname: Kwak
authors.forename: Hye-Eun
authors.initials: HE
authors.lastname: Kim
authors.forename: Sung Gyoo
authors.initials: SG
authors.lastname: Park
mesh_terms: D000818:Animals; D001119:Arginase / Q000378:metabolism; D001168:Arthritis / Q000276:immunology; D001249:Asthma / Q000276:immunology; D015551:Autoimmunity; D003713:Dendritic Cells / Q000276:immunology; D019693:Hepatitis, Autoimmune / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007108:Immune Tolerance; D007249:Inflammation / Q000378:metabolism*; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D009103:Multiple Sclerosis / Q000276:immunology; D022423:Myeloid Cells / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D030421:Peroxynitrous Acid; D010641:Phenotype; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D017382:Reactive Oxygen Species; D030421:Peroxynitrous Acid; D052247:Nitric Oxide Synthase Type II; D001119:Arginase