title: Intravenous Sodium Valproate for Acute Pediatric Headache.
abstract: BACKGROUND
  Headaches are common in the pediatric population, and increase in prevalence with age. The abortive medications currently used have a number of potential side effects. Sodium valproate (VPA) has been shown to be effective for acute treatment in the adult population, but no data exist in the pediatric population.
  
  
  OBJECTIVE
  The objective of this study was to evaluate the effectiveness of VPA for acute pediatric headache in the emergency department.
  
  
  METHODS
  This was a retrospective case series of all patients <19 years of age treated in the pediatric emergency department (PED) at two tertiary care pediatric hospitals and with a final diagnosis of migraine or headache who received parenteral VPA. Data collected included patient demographics, pain reduction, length of stay, and final disposition.
  
  
  RESULTS
  From July 2010 to February 2014, there were 16 patients who received VPA for acute headache in the PED; 4 were excluded. Eighty-three percent were discharged home. Mean length of stay in the PED before VPA was 395 min, and 120 min after VPA administration. Patients achieved a 17% mean pain score reduction before VPA and approximately an additional 40% mean pain reduction after VPA infusion.
  
  
  CONCLUSIONS
  VPA appears to be an effective agent for acute pediatric headache in this small series. Patients responded well to VPA in a relatively short amount of time. Further studies are needed to evaluate its effectiveness in combination with other first-line medications or as a single agent.
authors.affiliation: Department of Emergency Medicine, Oregon Health & Science University, Portland, Oregon; Department of Pediatrics, Division of Emergency Medicine, Randall Children's Hospital, Portland, Oregon.
authors.forename: David
authors.initials: D
authors.lastname: Sheridan
authors.affiliation: Department of Emergency Medicine, Oregon Health & Science University, Portland, Oregon.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Sun
authors.affiliation: Department of Emergency Medicine, Oregon Health & Science University, Portland, Oregon.
authors.forename: Patricia
authors.initials: P
authors.lastname: O'Brien
authors.affiliation: Department of Emergency Medicine, Oregon Health & Science University, Portland, Oregon.
authors.forename: Matthew
authors.initials: M
authors.lastname: Hansen
mesh_terms: D000208:Acute Disease; D061605:Administration, Intravenous; D000293:Adolescent; D002648:Child; D004636:Emergency Service, Hospital; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D005260:Female; D018682:GABA Agents / Q000008:administration & dosage*; D006261:Headache / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy*; D010372:Pediatrics / Q000379:methods; D012189:Retrospective Studies; D014635:Valproic Acid / Q000008:administration & dosage*
chemical_list: D004791:Enzyme Inhibitors; D018682:GABA Agents; D014635:Valproic Acid
keywords: emergency; headache; migraine; pediatric; valproate