title: Shoshin Beriberi in Critically-Ill patients: case series.
abstract: Thiamine plays a fundamental role in cellular metabolism. The classical syndrome caused by thiamine deficiency is beriberi, and its fulminant variant, once considered an uncommon finding, is now encountered among the critically ill.We present a case series of four critically ill non-septic non-alcoholic patients with severe lactic acidosis and refractory cardio-circulatory collapse caused by acute fulminant beriberi, which drastically responded to thiamine administration.In critical care settings, increased awareness of this life-threatening but reversible condition is a requirement, especially among patients receiving parenteral nutrition and those with unexplained recalcitrant lactic acidosis.
authors.affiliation: Pulmonary and critical section, Hotel Dieu de France Hospital, Saint Joseph University School of Medicine, 16-16830, Beirut, Lebanon. georgedabar@yahoo.com.
authors.forename: George
authors.initials: G
authors.lastname: Dabar
authors.affiliation: Pulmonary and critical section, Hotel Dieu de France Hospital, Saint Joseph University School of Medicine, 16-16830, Beirut, Lebanon. kareenhr@hotmail.com.
authors.forename: Carine
authors.initials: C
authors.lastname: Harmouche
authors.affiliation: Pulmonary and critical section, Hotel Dieu de France Hospital, Saint Joseph University School of Medicine, 16-16830, Beirut, Lebanon. bassem.habr@gmail.com.
authors.forename: Bassem
authors.initials: B
authors.lastname: Habr
authors.affiliation: Pulmonary and critical section, Hotel Dieu de France Hospital, Saint Joseph University School of Medicine, 16-16830, Beirut, Lebanon. riachy@dm.net.lb.
authors.forename: Moussa
authors.initials: M
authors.lastname: Riachi
authors.affiliation: Department of Medicine, Kidney and Dialysis Research Laboratory, Division of Nephrology, St. Elizabeth's Medical Center, 736 Cambridge Street, 02135, Boston, MA, USA. bertrand.jaber@steward.org.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Jaber
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D001602:Beriberi / Q000097:blood / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D016638:Critical Illness / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects*; D013831:Thiamine / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013831:Thiamine