title: The role of rhinovirus in children hospitalized for acute respiratory disease, Santa Fe, Argentina.
abstract: Human rhinoviruses (HRVs) were historically considered upper airway pathogens. However, they have recently been proven to cause infections in the lower respiratory tract, resulting in hospitalization of children with pneumonia, bronchiolitis, and chronic pulmonary obstruction. In this report, HRV frequency and seasonality are described together with patient clinical-epidemiological aspects. From a total of 452 surveyed samples, the HRV nucleic acids was detected in 172 (38.1%) and found in every month of the study year. 60% of inpatients with acute respiratory infection (ARI) associated with HRV were under 6 months of age and 31% had a clinical history, being preterm birth and recurrent wheezing the prevailing conditions. The most frequent discharge diagnoses were pneumonia (35.2%), bronchiolitis (32.4%), and bronchitis (12.4%). Fifteen point nine percent of patients required admission into intensive care units. The results obtained in this study demonstrated the association between HRV and children hospitalizations caused by ARI.
authors.affiliation: National Institute of Respiratory Diseases "Emilio Coni", National Administration of Laboratories and Health Institutes, Santa Fe, Argentina.
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Rudi
authors.affiliation: Childreńs Hospital "Dr. O. Alassia", Santa Fe, Argentina.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Molina
authors.affiliation: Childreńs Hospital "Dr. O. Alassia", Santa Fe, Argentina.
authors.forename: Rocío
authors.initials: R
authors.lastname: Díaz
authors.affiliation: Childreńs Hospital "Dr. O. Alassia", Santa Fe, Argentina.
authors.forename: Virginia
authors.initials: V
authors.lastname: Bonet
authors.affiliation: Department of Pediatrics, Hospital "J. B. Iturraspe", Santa Fe, Argentina.
authors.forename: Lucila
authors.initials: L
authors.lastname: Ortellao
authors.affiliation: Department of Pediatrics, Hospital "J. B. Iturraspe", Santa Fe, Argentina.
authors.forename: Diego
authors.initials: D
authors.lastname: Cantarutti
authors.affiliation: National Institute of Respiratory Diseases "Emilio Coni", National Administration of Laboratories and Health Institutes, Santa Fe, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Gómez
authors.affiliation: Department of Pediatrics, Hospital "J. B. Iturraspe", Santa Fe, Argentina.
authors.forename: Judith
authors.initials: J
authors.lastname: Pierini
authors.affiliation: Childreńs Hospital "Dr. O. Alassia", Santa Fe, Argentina.
authors.forename: Raquel
authors.initials: R
authors.lastname: Cociglio
authors.affiliation: National Institute of Respiratory Diseases "Emilio Coni", National Administration of Laboratories and Health Institutes, Santa Fe, Argentina.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Kusznierz
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001118:Argentina / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D005260:Female; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010850:Picornaviridae Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D012189:Retrospective Studies; D012229:Rhinovirus / Q000302:isolation & purification*; D012307:Risk Factors; D012621:Seasons
keywords: acute respiratory infection; nested RT-PCR; pediatric population; pneumonia; rhinovirus