title: Human papillomavirus infection and fertility alteration: a systematic review.
abstract: BACKGROUND
  HPV is the most prevalent sexually transmitted infection and its effect in cancer induction is well documented. HPV infections are mostly asymptomatic, but it is unclear whether HPV infections can result in alterations of reproductive health.
  
  
  OBJECTIVE
  To determine the relationship between human papillomavirus infections and reproductive health in both men and women.
  
  
  METHODS
  A systematic literature review was performed in PubMed and ScienceDirect data bases from January 1994 through August 2014.
  
  
  RESULTS
  HPV infections are shown to be significantly associated to many adverse effects in the reproductive function. These adverse effects were reported in different levels from cells production to pregnancy and may be related to the infecting genotype.
  
  
  CONCLUSIONS
  It appears from this study that HPV detection and genotyping could be of great value in infertility diagnosis at least in idiopathic infertility cases. Like for the risk of carcinogenesis, another classification of HPV regarding the risk of fertility alteration may be considered after deep investigations.
authors.affiliation: Laboratoire de Microbiologie et de Biologie moléculaire, Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohammed Ben Abdellah, Fez, Morocco; Laboratoire de Biotechnologies, Faculté des Sciences Dhar El Mahraz, Université Sidi Mohammed Ben Abdellah, Fez, Morocco.
authors.forename: Tiatou
authors.initials: T
authors.lastname: Souho
authors.affiliation: Laboratoire de Biotechnologies, Faculté des Sciences Dhar El Mahraz, Université Sidi Mohammed Ben Abdellah, Fez, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Benlemlih
authors.affiliation: Laboratoire de Microbiologie et de Biologie moléculaire, Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohammed Ben Abdellah, Fez, Morocco; Equipe micro-organismes, génomique et Facteurs Oncogènes, Laboratoire de Pathologie Humaine, Biomédecine et Environnement, Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohammed Ben Abdellah, Fez, Morocco.
authors.forename: Bahia
authors.initials: B
authors.lastname: Bennani
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D008297:Male; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology*; D011247:Pregnancy; D060728:Reproductive Health; D012661:Semen; D055101:Semen Analysis; D012749:Sexually Transmitted Diseases / Q000150:complications / Q000821:virology