title: Permanent renal failure induced by pentastarch.
abstract: Background. Controversy exists with volume resuscitation using crystalloids or colloids. Renal dysfunction has been reported with some colloids and osmotic agents, but remains poorly defined. Patient. We report the case of a 67-year-old male who had normal kidney function at baseline and who developed anuric ARF in relation to the administration of >10 litres of 10% pentastarch. A renal biopsy confirmed hydropic changes in tubular cells compatible with colloid-induced damage. Conclusion. This case demonstrates that hydroxyethyl starch preparations may be associated with acute kidney injury, and one should carefully consider their use, especially in patients with pre-existing renal dysfunction. Osmotic tubular cell lesions may be long lasting and irreversible.
authors.affiliation: Department of Medicine, Maisonneuve-Rosemont Hospital , University of Montreal.
authors.forename: Rahima
authors.initials: R
authors.lastname: Jamal
authors.affiliation: Division of Nephrology , Verdun Hospital.
authors.forename: Marc
authors.initials: M
authors.lastname: Ghannoum
authors.affiliation: Department of Medicine, Maisonneuve-Rosemont Hospital , University of Montreal.
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Naud
authors.affiliation: Department of Pathology.
authors.forename: Pierre-Paul
authors.initials: PP
authors.lastname: Turgeon
authors.affiliation: Divisions of Nephrology and Critical Care, Maisonneuve-Rosemont Hospital , University of Montreal , Montreal, QC , Canada.
authors.forename: Martine
authors.initials: M
authors.lastname: Leblanc
keywords: acute renal failure; colloid; hydroxyethyl starch; pentastarch