title: Bispecific antibodies, nanoparticles and cells: bringing the right cells to get the job done.
abstract: Pre-arming therapeutic cells with bispecific antibodies (BiAbs) before infusion can home the cells to specific tissue antigens in the body. With the development of nanotechnology, we developed a novel strategy, namely magnetic bispecific cell engager (MagBICE), that combines BiAbs with biodegradable iron nanoparticles. Compared to conventional BiAbs, the latter enables magnetic targeting and imaging. This editorial discusses current knowledge of BiAbs and their applications in targeting activated T cells to cancerous tissues or targeting bone marrow-derived stem cells to myocardial infarction. We will also discuss the fabrication of MagBICE and its application in treating rodents with myocardial infarction.
authors.affiliation: North Carolina State University, College of Veterinary Medicine, Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research , Raleigh, NC , USA.
authors.forename: Junnan
authors.initials: J
authors.lastname: Tang
authors.forename: Deliang
authors.initials: D
authors.lastname: Shen
authors.forename: Jinying
authors.initials: J
authors.lastname: Zhang
authors.forename: Frances S
authors.initials: FS
authors.lastname: Ligler
authors.forename: Ke
authors.initials: K
authors.lastname: Cheng
mesh_terms: D000818:Animals; D018033:Antibodies, Bispecific / Q000276:immunology*; D017493:Leukocyte Common Antigens / Q000276:immunology; D008213:Lymphocyte Activation; D008280:Magnetics; D051379:Mice; D009203:Myocardial Infarction / Q000628:therapy; D018994:Myosin Light Chains / Q000276:immunology; D053758:Nanoparticles / Q000737:chemistry*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D018033:Antibodies, Bispecific; D018994:Myosin Light Chains; D017493:Leukocyte Common Antigens
keywords: bispecific antibody; cell therapy; cytotoxic T cells; magnetic nanoparticles; regenerative medicine