title: Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis.
abstract: Curcumin is a major component of turmeric and reportedly has anti-inflammatory and anti-oxidant effects. Neuroinflammation has been recognized to play an important role in the pathogenesis of various diseases in the central nervous system. Here we investigated the anti-nociceptive and anti-neuroinflammatory effect of curcumin on arthritic pain in rats. We found that repeated oral treatment with curcumin, either before or after complete Freund's adjuvant (CFA) injection, dose-dependently attenuated CFA-induced mechanical allodynia and thermal hyperalgesia, but had no effect on joint edema. Repeated intrathecal injection of curcumin reversed CFA-induced pain hypersensitivity. Furthermore, such a curcumin treatment reduced CFA-induced activation of glial cells and production of inflammatory mediators [interleukin-1β (IL-1β), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1α)] in the spinal cord. Curcumin also decreased lipopolysaccharide-induced production of IL-1β, tumor necrosis factor-α, MCP-1, and MIP-1α in cultured astrocytes and microglia. Our results suggest that intrathecal curcumin attenuates arthritic pain by inhibiting glial activation and the production of inflammatory mediators in the spinal cord, suggesting a new application of curcumin for the treatment of arthritic pain.
authors.affiliation: 1] Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China [2] Pain Research Laboratory, Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu 226019, China.
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Chen
authors.affiliation: Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Dai
authors.affiliation: Pain Research Laboratory, Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu 226019, China.
authors.forename: Lin-Xia
authors.initials: LX
authors.lastname: Zhao
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, China.
authors.forename: Su
authors.initials: S
authors.lastname: Cao
authors.affiliation: Pain Research Laboratory, Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu 226019, China.
authors.forename: Yong-Jing
authors.initials: YJ
authors.lastname: Gao
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D001253:Astrocytes / Q000187:drug effects / Q000473:pathology; D002478:Cells, Cultured; D018932:Chemokine CCL2 / Q000096:biosynthesis; D054405:Chemokine CCL3 / Q000096:biosynthesis; D003474:Curcumin / Q000008:administration & dosage / Q000627:therapeutic use*; D006930:Hyperalgesia / Q000188:drug therapy*; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D007278:Injections, Spinal; D053583:Interleukin-1beta / Q000096:biosynthesis; D008070:Lipopolysaccharides; D008297:Male; D017628:Microglia / Q000187:drug effects / Q000473:pathology; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D013131:Spine / Q000473:pathology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; C491766:Ccl2 protein, rat; D018932:Chemokine CCL2; D054405:Chemokine CCL3; C000594089:IL1B protein, rat; D053583:Interleukin-1beta; D008070:Lipopolysaccharides; D003474:Curcumin