title: Primary extranodal non-hodgkin lymphoma of the head and neck in patients with acquired immunodeficiency syndrome: a clinicopathologic study of 24 patients in a single hospital of infectious diseases in Argentina.
abstract: Introduction Extranodal non-Hodgkin lymphomas (NHLs) are commonly described in patients with acquired immunodeficiency syndrome (AIDS) and are related with an atypical morphology and aggressive clinical course. AIDS-associated lymphomas are characterized by their rapid progression, frequent extranodal manifestations, and poor outcome. Objective The aim of this article is to remake the clinical features of head and neck (HN) NHL in patients with AIDS to facilitate early diagnosis and treatment. Methods We evaluated the epidemiologic, clinical, immunologic, virologic, and histopathologic characteristics of 24 patients with human immunodeficiency virus (HIV)/AIDS with primary HN NHL treated at a single institution between 2002 and 2012. Histopathologic diagnosis was made according to the criteria of the World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues. Additional immunohistochemical stains were applied in all cases. Results Eighteen patients (75%) were men and the median of age was 39 years. The gingiva and the hard palate were the most common sites of the lesions (15 patients, 62.5%). Lactate dehydrogenase levels were elevated in 16 cases (84%). Bone marrow infiltration was detected only in 4 cases (16.6%). The median CD4 T-cell count was 100 cells/µL. According to the histopathologic evaluation, the most common subtype was diffuse large B-cell lymphoma (12 cases, 50%), followed by plasmablastic lymphoma (9 cases, 37.5%) and Burkitt lymphoma (3 cases, 12.5%). Conclusion HN NHL is a severe complication of advanced HIV/AIDS disease. Early diagnosis followed by chemotherapy plus highly active antiretroviral treatment is necessary to improve the prognosis and the survival of these patients.
authors.affiliation: Department of HIV/AIDS, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina ; Department of Internal Medicine, University of Buenos Aires School of Medicine, Paraguay, Buenos Aires, Argentina.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Corti
authors.affiliation: Department of HIV/AIDS, Infectious Diseases F. J. Muñiz Hospital, Buenos Aires, Argentina.
authors.forename: María
authors.initials: M
authors.lastname: Villafañe
authors.affiliation: Department of Oncology, Ramos Mejía Hospital, Buenos Aires, Argentina.
authors.forename: Alicia
authors.initials: A
authors.lastname: Bistmans
authors.affiliation: Department of Histopathology, National Academy of Medicine, Buenos Aires, Argentina.
authors.forename: Marina
authors.initials: M
authors.lastname: Narbaitz
authors.affiliation: Department of Scientific Coordinator, Sociedad Iberoamericana de Información Científica, Buenos Aires, Argentina.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Gilardi
keywords: AIDS; HIV; head and neck; non-Hodgkin lymphoma