title: Anti-Proliferation Potential and Content of Fucoidan Extracted from Sporophyll of New Zealand Undaria pinnatifida.
abstract: Undaria pinnatifida is a species of brown seaweed known to contain rich amounts of fucoidan, a sulfated polysaccharide known to possess various biological activities. We isolated crude fucoidan (F0) from the sporophylls of U. pinnatifida grown in the Marlborough Sounds, New Zealand. Sulfate content, uronic acid content, and molecular weight of F0 were 15.02, 1.24, and >150 kDa, respectively. F0 was fractionated to yield three further fractions: F1, F2, and F3. Cytotoxicity of two major fractions was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The algal fucoidans specifically suppressed the proliferation of three cancer cell lines with less cytotoxicity against the normal cells. Selective cytotoxicity could relate to the distinctive structures of each fucoidan fraction. Results from this study provide evidence that fucoidan, especially from U. pinnatifida grown in New Zealand, possesses great potential to be used as a functional food to reduce cancer risk or supplement cancer treatment.
authors.affiliation: School of Applied Sciences, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand.
authors.forename: Wilfred
authors.initials: W
authors.lastname: Mak
authors.affiliation: School of Applied Sciences, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand.
authors.forename: Sheng Kelvin
authors.initials: SK
authors.lastname: Wang
authors.affiliation: School of Applied Sciences, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand.
authors.forename: Tingting
authors.initials: T
authors.lastname: Liu
authors.affiliation: School of Applied Sciences, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand ; Institute for Applied Ecology New Zealand, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand.
authors.forename: Nazimah
authors.initials: N
authors.lastname: Hamid
authors.affiliation: Institute for Applied Ecology New Zealand, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand ; School of Interprofessional Health Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Applied Sciences, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand ; Institute for Applied Ecology New Zealand, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand ; School of Interprofessional Health Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand ; Institute of Biomedical Technology, Auckland University of Technology , Auckland , New Zealand.
authors.forename: Jun
authors.initials: J
authors.lastname: Lu
authors.affiliation: School of Applied Sciences, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand ; Institute for Applied Ecology New Zealand, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand ; School of Interprofessional Health Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology , Auckland , New Zealand.
authors.forename: William Lindsey
authors.initials: WL
authors.lastname: White
keywords: Undaria pinnatifida; cytotoxicity; extraction; fractionation; fucoidan; sporophyll