title: Serum vitamin D levels in a cohort of adult and pediatric patients with eosinophilic esophagitis.
abstract: BACKGROUND
  Vitamin D deficiency has been associated with increased risk for severe asthma, challenge-proven food allergy, and severe atopic dermatitis. Vitamin D levels have not been reported in patients with eosinophilic esophagitis (EoE).
  
  
  OBJECTIVE
  To determine levels of 25-hydroxyvitamin D in a cohort of patients with EoE.
  
  
  METHODS
  Total serum 25-hydroxyvitamin D was measured using liquid chromatography with tandem mass spectroscopy in adults (n = 35) and children (n = 34) with EoE. Results were compared with patient demographics, EoE-specific disease parameters, markers of sensitization, and features of severity using multivariable logistic regression.
  
  
  RESULTS
  The median vitamin D level was 28.9 ng/mL. Patients with insufficient vitamin D (<30 ng/mL) were older (median 25.5 vs 16.2 years) and had a higher body mass index (median 25.2 vs 19.8 kg/m(2)). Peak median esophageal eosinophil counts were not significantly different for vitamin D insufficient and sufficient patient groups; however, higher vitamin D levels correlated with higher histologic eosinophil counts (R = 0.61, P = .03). Although there were no statistical differences in total IgE or levels of specific IgE between patients with vitamin D insufficiency and those with sufficiency, a positive skin prick test reaction to peanut was more common in patients who had vitamin D insufficiency (adjusted odds ratio 7.57, P = .009). Vitamin D insufficiency was not associated with surrogate markers of severity (dilation in adults or hospitalization or emergency visits in children).
  
  
  CONCLUSIONS
  In these patients with EoE, vitamin D levels were low overall (median <30 ng/mL). The only marker of sensitization associated with insufficient vitamin D in these patients with EoE was a positive skin prick test reaction to peanut.
authors.affiliation: Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address: mariaslackai@gmail.com.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Slack
authors.affiliation: Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio.
authors.forename: Princess U
authors.initials: PU
authors.lastname: Ogbogu
authors.affiliation: Department of Biomedical Informatics, Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, Ohio.
authors.forename: Gary
authors.initials: G
authors.lastname: Phillips
authors.affiliation: Division of Allergy and Immunology, University of Virginia, Charlottesville, Virginia.
authors.forename: Thomas A E
authors.initials: TA
authors.lastname: Platts-Mills
authors.affiliation: Center for Innovation in Pediatric Practice, Nationwide Children's Hospital, Columbus, Ohio.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Erwin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000485:Allergens / Q000009:adverse effects / Q000276:immunology; D010367:Arachis / Q000009:adverse effects / Q000276:immunology; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D057765:Eosinophilic Esophagitis / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007223:Infant; D008297:Male; D008875:Middle Aged; D012130:Respiratory Hypersensitivity / Q000097:blood / Q000453:epidemiology; D012621:Seasons; D012882:Skin Tests; D053719:Tandem Mass Spectrometry; D014481:United States / Q000453:epidemiology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000485:Allergens; D014807:Vitamin D; D007073:Immunoglobulin E; C104450:25-hydroxyvitamin D