title: [Development of Tripterygium glycosides nano-carries based on "nanoemulsion-gels" and its pharmacodynamics].
abstract: The aim of this study is to develop the Tripterygium glycosides nanoemulsion gels and investigate its pharmacodynamics. Oleic acid was used as oil phase, polyoxyethylene castor oil as surfaetant, and 1,2-propanediol as cosurfactant to screen the formula of Tripterygium glycoside nanoemulsion using the pseudo-temary phase diagrams. Then the nanoemulsion gels was prepared. The ICR mouse ears were sensitazated by 7% DNCB, and then were excited by 0.3% DNCB to stimulate the model of mouse chronic dermatitis and eczema. The concentrations of IFN-γ, IL-4 and IL-8 in mouse blood were determined by ELISA. The results showed that Tripterygium glycosides nanoemulsion gels could significantly inhibit the swelling of mouse ears(P < 0.01) and ameliorate the edama and erythema of model mouse ears skin. Also it could significantly decrease the expression of IFN-γ and IL-4 in model mouse blood. Tripterygium glycosides nanoemulsion gels had a good therapeutic effect on mouse model of dermatitis and eczema. It was expected to provide a new and long-acting exterernal preparation for the treatment of dermatitis and eczema.
authors.forename: Qing
authors.initials: Q
authors.lastname: Gu
authors.forename: Ben-Ming
authors.initials: BM
authors.lastname: You
authors.forename: Di-Shun
authors.initials: DS
authors.lastname: Yang
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Pan
authors.forename: Wei
authors.initials: W
authors.lastname: Shu
authors.forename: Ji-Yong
authors.initials: JY
authors.lastname: Liu
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D003872:Dermatitis / Q000188:drug therapy* / Q000276:immunology; D004337:Drug Carriers / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics*; D004655:Emulsions / Q000737:chemistry; D005260:Female; D006027:Glycosides / Q000737:chemistry* / Q000493:pharmacokinetics*; D006801:Humans; D015847:Interleukin-4 / Q000276:immunology; D016209:Interleukin-8 / Q000276:immunology; D051379:Mice; D008813:Mice, Inbred ICR; D053758:Nanoparticles / Q000737:chemistry*; D029757:Tripterygium / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D006027:Glycosides; D016209:Interleukin-8; D015847:Interleukin-4