title: Successful treatment of non-Hodgkin's lymphoma with rituximab and dose-adjusted CHOP therapy in a patient with concomitant end-stage renal disease requiring haemodialysis.
abstract: Although malignancy is a fatal complication of end-stage renal disease (ESRD) requiring haemodialysis, successful treatment of haematological malignancies has been rarely reported. We describe the case of a 64-year-old man who presented with non-Hodgkin's lymphoma (NHL; clinical stage, IVB) concomitant with ESRD. Before chemotherapy, haemodialysis was initiated, and one course of dose-adjusted CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) therapy followed by eight courses of rituximab therapy were administered according to the performance status and degree of organ dysfunction. Consequently, the patient was disease free for 27 months. Thus, rituximab plus CHOP combination therapy was effective for NHL concomitant with ESRD.
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kawano
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Yokota-Ikeda
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Kawano
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
authors.forename: Shuro
authors.initials: S
authors.lastname: Yoshida
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yamashita
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Kodama
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Uezono
authors.affiliation: Department of Pathlogy, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Shimao
authors.affiliation: Faculity of Letters, University of Keio, Tokyo, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Kawano
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Ueda
keywords: end-stage renal disease; haemodialysis; non-Hodgkin's lymphoma; rituximab and dose-adjusted CHOP therapy