title: Meta-analysis of incomplete microarray studies.
abstract: Meta-analysis of microarray studies to produce an overall gene list is relatively straightforward when complete data are available. When some studies lack information-providing only a ranked list of genes, for example-it is common to reduce all studies to ranked lists prior to combining them. Since this entails a loss of information, we consider a hierarchical Bayes approach to meta-analysis using different types of information from different studies: the full data matrix, summary statistics, or ranks. The model uses an informative prior for the parameter of interest to aid the detection of differentially expressed genes. Simulations show that the new approach can give substantial power gains compared with classical meta-analysis and list aggregation methods. A meta-analysis of 11 published studies with different data types identifies genes known to be involved in ovarian cancer and shows significant enrichment.
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, EPFL-FSB-MATHAA-STAT, Station 8, 1015 Lausanne, Switzerland alix.leboucq@alumni.epfl.ch.
authors.forename: Alix
authors.initials: A
authors.lastname: Zollinger
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, EPFL-FSB-MATHAA-STAT, Station 8, 1015 Lausanne, Switzerland.
authors.forename: Anthony C
authors.initials: AC
authors.lastname: Davison
authors.affiliation: Ecole Polytechnique Fédérale de Lausanne, EPFL-FSB-MATHAA-STAT, Station 8, 1015 Lausanne, Switzerland.
authors.forename: Darlene R
authors.initials: DR
authors.lastname: Goldstein
mesh_terms: D005260:Female; D015870:Gene Expression; D006801:Humans; D015201:Meta-Analysis as Topic; D046228:Microarray Analysis / Q000379:methods*; D015233:Models, Statistical; D010051:Ovarian Neoplasms / Q000235:genetics*
keywords: Bayesian hierarchical model; Gibbs sampler; Horseshoeprior; Microarray; Normal-gamma prior; Serous ovarian cancer; Spike and slab prior