title: Effect of coenzyme Q10 on glycaemic control, oxidative stress and adiponectin in type 2 diabetes.
abstract: OBJECTIVE
  To assess the effects of Coenzyme Q10 supplementation on glycaemic control, oxidative stress and adiponectin levels in people with type 2 diabetes.
  
  
  METHODS
  The randomised, single-blind, placebo-controlled study was conducted in the city of Shiraz, Iran, in 2012 and comprised type 2 diabetes subjects recruited from various health facilities. Subjects and controls received 100mg Coenzyme Q10 or placebo twice a day for eight weeks respectively. A variety of measurements were made at baseline and at the end of the intervention. These included measuring markers of glycaemic control (fasting blood glucose and glycated haemoglobin); a marker of oxidative stress (malondialdehyde); and an anti-inflammatory marker (adiponectin). SPSS 15 was used for statistical analysis.
  
  
  RESULTS
  Of the 52 patients, 28(54%) were male and 24(46%) were female, with an overall mean age of 51.73±7.34 years. There were 16(62% male and 10(39%) females in the intervention group, and 12(46%) male and 14(54%) female subjects in the control group. Among the cases, Coenzyme Q10 resulted in a significant reduction in malondialdehyde levels (p=0.04). However, the difference within the controls for this factor was not significant (p>-0.05). Moreover, fasting blood glucose, glycated haemoglobin and adiponectin levels showed no significant differences within or between the groups (p>0.05 each).
  
  
  CONCLUSIONS
  Coenzyme supplementation may reduce oxidative stress in type 2 diabetics. However, it may not have any effects on glycaemic control and adiponectin levels.
authors.affiliation: Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mahsa
authors.initials: M
authors.lastname: Moazen
authors.affiliation: School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Mazloom
authors.affiliation: School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Afsane
authors.initials: A
authors.lastname: Ahmadi
authors.affiliation: Endocrine and Metabolism Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Dabbaghmanesh
authors.affiliation: Center for Development of Clinical Studies, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Sareh
authors.initials: S
authors.lastname: Roosta
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism; D016903:Drug Monitoring; D045222:Electron Transport Chain Complex Proteins / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis / Q000378:metabolism; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D016896:Treatment Outcome; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D045222:Electron Transport Chain Complex Proteins; D006442:Glycated Hemoglobin; D008315:Malondialdehyde; D014451:Ubiquinone; D014815:Vitamins; C024989:coenzyme Q10
keywords: Coenzyme Q10, Diabetes mellitus, Blood glucose, Oxidative stress, Inflammation.