title: Langerhans cell histiocytosis followed by hodgkin lymphoma: a case report.
abstract: Langerhans cell histiocytosis (LCH) is a rare neoplasm defined as the proliferation of bone marrow langerhans cells, which is a kind of dendritic cells. The major pathological features of LCH are expression of CD1a and S100 as well as Birbeck granules. Its presentation can differ from a mild bone lesion to a multi-systemic evolved malignant neoplasm; however, the latter outcome is almost rare. Thus, LCH is mostly known as a benign neoplasm. In this study, we present a case of LCH followed by Hodgkin lymphoma (HL). Accompaniment of this disease with malignant lymphoma is rare and considered as case report. Several cases in which malignant lymphoma occurred prior to LCH are reported; however, few cases can be found with LCH followed by malignant lymphomas.
authors.affiliation: Department of Pathology, Molecular Pathology and Cytogenetic Ward, Shiraz University of Medical Sciences, Iran;
authors.forename: Akbar
authors.initials: A
authors.lastname: Safaei
authors.affiliation: Department of Pathology, Molecular Pathology and Cytogenetic Ward, Shiraz University of Medical Sciences, Iran;
authors.forename: Mandana
authors.initials: M
authors.lastname: Bagheri
authors.affiliation: Department of Pathology, Molecular Pathology and Cytogenetic Ward, Shiraz University of Medical Sciences, Iran;
authors.forename: Jahanbanoo
authors.initials: J
authors.lastname: Shahryari
authors.affiliation: Department of Pathology, Molecular Pathology and Cytogenetic Ward, Shiraz University of Medical Sciences, Iran;
authors.forename: Sadat
authors.initials: S
authors.lastname: Noori
authors.affiliation: Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Elmira
authors.initials: E
authors.lastname: Esmailzade
keywords: Hodgkin disease; Immunohistochemistry; Langerhans cell histiosis