title: [Induction of type 1, 2 and 3 interferons by acridone acetates].
abstract: The induction profile of endogenous interferons of three types under the action of meglumine acridone acetate and sodium acridone acetate, as well as the characteristics of the kinetics of their accumulation and circulation in the blood of experimental animals are described. Meglumine acridone acetate provided balance in induction, production and circulation of the interferons in the blood vs. sodium aeridone acetate under the same conditions. The optimal dose of meglumine acridone acetate (2.0-3.5 mg/mouse) with effective, consecutive and overlapping induction-production of the interferons ensured their prolonged (for 72 hours) circulation in the blood after a single administration.
authors.forename: S S
authors.initials: SS
authors.lastname: Grigoryan
authors.forename: A Yu
authors.initials: AY
authors.lastname: Petrov
authors.forename: E I
authors.initials: EI
authors.lastname: Isaeva
authors.forename: M A
authors.initials: MA
authors.lastname: Muzykin
authors.forename: A L
authors.initials: AL
authors.lastname: Kovalenko
authors.forename: M G
authors.initials: MG
authors.lastname: Romantsov
mesh_terms: D054831:Acridones / Q000008:administration & dosage*; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood; D005260:Female; D007369:Interferon Inducers / Q000008:administration & dosage*; D016898:Interferon-alpha / Q000096:biosynthesis* / Q000097:blood; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000097:blood; D008536:Meglumine / Q000008:administration & dosage*; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors; D007378:Interleukins; D000095022:Interferon Lambda
chemical_list: D054831:Acridones; D016207:Cytokines; D007369:Interferon Inducers; D016898:Interferon-alpha; D007371:Interferon-gamma; D008536:Meglumine; C511668:interferon-lambda protein, mouse; D007378:Interleukins; D000095022:Interferon Lambda