title: Prognostic value of troponins in acute nonmassive pulmonary embolism: A meta-analysis.
abstract: The objective of our meta-analysis is to update the evidence on the prognostic value of elevated troponin levels in patient with acute normotensive pulmonary embolism (PE). We did a systematic literature review of database, including Pubmed, EMBASE, and Cochrane. Studies were included if those were done on normotensive patients with acute PE and serum troponin assay was done. The primary end point was short term all cause mortality. The secondary end points were short term PE related mortality and serious adverse events. Elevated troponin levels were significantly associated with the increased risk for short term mortality (odds ratio [OR], 4.80; 95% CI, 3.25-7.08, I(2) = 54%), PE related mortality (OR, 3.80; 95% CI, 2.74-5.27, I(2) = 0%) and serious adverse events (OR, 3.65; 95% CI, 2.41-5.53, I(2) = 47%). Our study suggests that elevated levels of troponin identify a subgroup of patients with increased risk for short term mortality and serious adverse events.
authors.affiliation: The Wright Center for Graduate Medical Education, 501 Madison Avenue, Scranton, PA, USA. Electronic address: dr.anuragbajaj@gmail.com.
authors.forename: Anurag
authors.initials: A
authors.lastname: Bajaj
authors.affiliation: The Wright Center for Graduate Medical Education, 501 Madison Avenue, Scranton, PA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Saleeb
authors.affiliation: Zhengzhou University, 100 Ke Xue Da Dao, Zhongyuan, Zhengzhou, Henan, China.
authors.forename: Parul
authors.initials: P
authors.lastname: Rathor
authors.affiliation: The Common Wealth Medical College, 525 Pine Street, Scranton, PA, USA.
authors.forename: Vishal
authors.initials: V
authors.lastname: Sehgal
authors.affiliation: Pulmonary and Critical Care Division, The Common Wealth Medical College, 525 Pine Street, Scranton, PA, USA.
authors.forename: Besher
authors.initials: B
authors.lastname: Kabak
authors.affiliation: Critical Care Division, Geisinger Medical Center, 1800 Mulberry Street, Scranton, PA, USA.
authors.forename: Srikanth
authors.initials: S
authors.lastname: Hosur
mesh_terms: D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D011655:Pulmonary Embolism / Q000401:mortality* / Q000503:physiopathology; D014336:Troponin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D014336:Troponin
keywords: Mortality; Prognosis; Pulmonary embolism; Right ventricular dysfunction; Troponin