title: Eosinophilic esophagitis as paraneoplastic syndrome in a patient with ganglioneuroblastoma.
abstract: A 16-month-old boy presented with failure to thrive despite sufficient caloric intake, hypersalivation, abdominal pain, chronic diarrhea and blepharitis. An eosinophilic esophagitis (EoE) was diagnosed by esophageal biopsy. Dietary restrictions and topical steroid treatment lead to no improvement. Further diagnostic work-up revealed an intrathoracal, paraspinal ganglioneuroblastoma. After operative extirpation of the tumour, all initial symptoms resolved. An esophageal control biopsy 4 weeks after tumour resection was normal. This is the first report of eosinophilic esophagitis as part of a paraneoplastic syndrome in a patient with a malignant disease other than a carcinoma.
authors.affiliation: Immunology, University Children's Hospital Zurich, Zurich, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Prader
authors.affiliation: Gastroenterology, Children's Hospital Lucerne, Lucerne, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Spalinger
authors.affiliation: Radiology, Hospital Lucerne, Lucerne, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Caduff
authors.affiliation: Pathology, Hospital Lucerne, Lucerne, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Hürlimann
authors.affiliation: Pediatric Haematology and Oncology, Cantonal Hospital Lucerne, Lucerne, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Rischewski
mesh_terms: D003937:Diagnosis, Differential; D057765:Eosinophilic Esophagitis / Q000175:diagnosis* / Q000601:surgery; D018305:Ganglioneuroblastoma / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000601:surgery; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D013904:Thoracic Vertebrae; D014057:Tomography, X-Ray Computed