title: Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application.
abstract: The catalyst which is used in the signal amplification by reversible exchange (SABRE) process facilitates substrate hyperpolarisation while acting to speed up the rate of relaxation. Consequently, the lifetime over which the hyperpolarised contrast agent is visible is drastically reduced. We show that the addition of a chelating ligand, such as bipyridine, rapidly deactivates the SABRE catalyst thereby lengthening the agent's relaxation times and improving the potential of SABRE for diagnostic MRI.
authors.affiliation: Centre for Hyperpolarisation in Magnetic Resonance, University of York, Heslington, York YO10 5NY, UK. simon.duckett@york.ac.uk.
authors.forename: Ryan E
authors.initials: RE
authors.lastname: Mewis
authors.forename: Marianna
authors.initials: M
authors.lastname: Fekete
authors.forename: Gary G R
authors.initials: GG
authors.lastname: Green
authors.forename: Adrian C
authors.initials: AC
authors.lastname: Whitwood
authors.forename: Simon B
authors.initials: SB
authors.lastname: Duckett
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry*; D002384:Catalysis; D003287:Contrast Media / Q000737:chemistry; D007495:Iridium / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009536:Niacinamide / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry
chemical_list: D003287:Contrast Media; D010618:Phenanthrolines; D009536:Niacinamide; D007495:Iridium; D015082:2,2'-Dipyridyl; C025205:1,10-phenanthroline