title: Development and trafficking function of haematopoietic stem cells and myeloid cells during fetal ontogeny.
abstract: Fetal haematopoiesis is a highly regulated process in terms of time and location. It is characterized by the emergence of specific cell populations at different extra- and intraembryonic anatomical sites. Trafficking of haematopoietic stem cells (HSCs) between these supportive niches is regulated by a set of molecules, i.e. integrins and chemokine receptors, which are also described for the recruitment of differentiated innate immune cells. In this review, an overview will be given on fetal haematopoiesis as well as trafficking of HSCs during fetal life. In addition, we will focus on the appearance of the first differentiated neutrophils and monocytes in the fetal circulation and describe how they acquire the ability to roll, adhere, and transmigrate into inflamed fetal tissue. Furthermore, we will discuss other effector functions of innate immune cells evolving during fetal ontogeny.
authors.affiliation: Walter-Brendel-Center of Experimental Medicine, Ludwig-Maximilians Universität, Marchioninistr. 15, Munich 81377, Germany.
authors.forename: Kristina
authors.initials: K
authors.lastname: Heinig
authors.affiliation: Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Fanny
authors.initials: F
authors.lastname: Sage
authors.affiliation: Hubrecht Institute-KNAW & University Medical Center Utrecht, Utrecht, The Netherlands Department of Cell Biology, University Medical Center, Utrecht, The Netherlands.
authors.forename: Catherine
authors.initials: C
authors.lastname: Robin
authors.affiliation: Walter-Brendel-Center of Experimental Medicine, Ludwig-Maximilians Universität, Marchioninistr. 15, Munich 81377, Germany markus.sperandio@lmu.de markus.sperandio@lrz.uni-muenchen.de.
authors.forename: Markus
authors.initials: M
authors.lastname: Sperandio
mesh_terms: D000818:Animals; D047109:Fetal Development / Q000276:immunology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D009000:Monocytes / Q000502:physiology*; D022423:Myeloid Cells / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*
keywords: Fetal; Haematopoiesis; Innate immunity; Leucocyte recruitment