title: The occurrence of auditory dysfunction in children with TB receiving ototoxic medication at a TB hospital in South Africa.
abstract: OBJECTIVE
  to describe the auditory dysfunction of children with tuberculosis receiving ototoxic medication at a residential TB hospital in the Cape Town metropolitan area.
  
  
  METHODS
  A descriptive survey research design was adopted. The auditory status of participants was evaluated by otoscopy, immittance, audiometry or OAE and AABR (depending on the age).
  
  
  METHODS
  29 in-patients (7 months to 16.6 years).
  
  
  RESULTS
  Fifty five percent of participants presented with middle ear abnormalities (n=16) and 48% (n=12) had sensorineural or mixed hearing loss. The degree of hearing loss ranged from mild to profound in 16% of the ears. The conventional pure-tone average of .5, 1, & 2 kHz did not allow for the determination of the degree of hearing loss in the remaining 18% which had high frequency hearing loss.
  
  
  CONCLUSIONS
  The high occurrence of hearing loss necessitates the implementation of monitoring program for children receiving ototoxic medication. Consideration should be given to using the average of hearing thresholds at 4, 6 and 8 kHz to determine the classification of degree of hearing loss in cases of ototoxicity.
authors.affiliation: Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7935, South Africa. Electronic address: Nazanin_gh59@yahoo.com.
authors.forename: Nazanin
authors.initials: N
authors.lastname: Ghafari
authors.affiliation: Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7935, South Africa. Electronic address: Christine.rogers@uct.ac.za.
authors.forename: Christine
authors.initials: C
authors.lastname: Rogers
authors.affiliation: Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7935, South Africa. Electronic address: Lucretia.petersen@uct.ac.za.
authors.forename: Lucretia
authors.initials: L
authors.lastname: Petersen
authors.affiliation: Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7935, South Africa. Electronic address: Shajila.singh@uct.ac.za.
authors.forename: Shajila A
authors.initials: SA
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D006314:Hearing Loss, Conductive / Q000175:diagnosis / Q000209:etiology; D046089:Hearing Loss, Mixed Conductive-Sensorineural / Q000175:diagnosis / Q000209:etiology; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000175:diagnosis; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D013019:South Africa; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents
keywords: Children; Hearing loss; Monitoring; Ototoxicity; TB