title: New directions for the treatment of adrenal insufficiency.
abstract: Adrenal disease, whether primary, caused by defects in the hypothalamic-pituitary-adrenal (HPA) axis, or secondary, caused by defects outside the HPA axis, usually results in adrenal insufficiency, which requires lifelong daily replacement of corticosteroids. However, this kind of therapy is far from ideal as physiological demand for steroids varies considerably throughout the day and increases during periods of stress. The development of alternative curative strategies is therefore needed. In this review, we describe the latest technologies aimed at either isolating or generating de novo cells that could be used for novel, regenerative medicine application in the adrenocortical field.
authors.affiliation: Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London , UK.
authors.forename: Gerard
authors.initials: G
authors.lastname: Ruiz-Babot
authors.affiliation: Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London , UK.
authors.forename: Irene
authors.initials: I
authors.lastname: Hadjidemetriou
authors.affiliation: Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London , UK.
authors.forename: Peter James
authors.initials: PJ
authors.lastname: King
authors.affiliation: Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London , UK.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Guasti
keywords: SF1; adrenal cortex; encapsulation; regeneration; stem cells; steroidogenesis; transplantation; zonation