title: Onset of efficacy and residual speed of kill over one month of a topical dinotefuran-permethrin-pyriproxyfen combination (Vectra ® 3D) against the adult cat flea (Ctenocephalides felis felis) on dogs.
abstract: This study was designed to assess the onset of therapeutic and residual insecticidal efficacy of a topical ectoparasiticide (Vectra(®)3D, DPP) on dogs over one month against the cat flea, Ctenocephalides felis felis. Adult dogs (n=32, 11.0-18.7 kg) were infested with 100 adult fleas on days -6, -2, 7, 14, 21 and 28. Based on flea retention, the dogs were allocated in two groups and were treated topically on day 0 with a control solution (CS) or DPP. Each group was divided in two subgroups in which live fleas were counted by combing the dogs 2 or 6h after treatment and at each re-infestation. The insecticidal efficacy was calculated using arithmetic and geometric means at each time point. The flea retention rate ranged from 64.0 to 86.5% in the CS group throughout the study. Based on arithmetic means, the therapeutic efficacy was 96.4% 6h post-treatment and residual efficacies ranged from 96.8 to 99.9% 2h after each re-infestation. The residual speed of killing effectiveness, >96% at 2h, persisted for one month after treatment. DPP administration was well tolerated. This study confirms that DPP starts killing fleas within 2h after treatment and reaches efficacy levels >95% at 6h. We have shown that DPP kills >96.8% of fleas for one month after treatment within 2h after infestation.
authors.affiliation: Ceva Santé Animale S. A., 10 Avenue de la Ballastière, 33500 Libourne, France. Electronic address: marie.varloud@ceva.com.
authors.forename: Marie
authors.initials: M
authors.lastname: Varloud
authors.affiliation: ClinVet International (Pty) Ltd., P.O. Box 11186, Universitas 9321, South Africa.
authors.forename: Josephus J
authors.initials: JJ
authors.lastname: Fourie
mesh_terms: D000287:Administration, Topical; D000818:Animals; D058251:Ctenocephalides / Q000187:drug effects*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D058267:Flea Infestations / Q000188:drug therapy / Q000662:veterinary*; D006146:Guanidines / Q000008:administration & dosage*; D007306:Insecticides / Q000008:administration & dosage*; D008297:Male; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000008:administration & dosage*; D026023:Permethrin / Q000008:administration & dosage*; D011108:Polymers; D011725:Pyridines / Q000008:administration & dosage*
chemical_list: D004338:Drug Combinations; D006146:Guanidines; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011108:Polymers; D011725:Pyridines; C422409:liquid crystal polymer; C465368:dinotefuran; C055613:pyriproxyfen; D026023:Permethrin
keywords: Canis familiaris; Control; Flea adulticidal efficacy; Insecticide; Prevention