title: Proteomics in cancer biomarkers discovery: challenges and applications.
abstract: With the introduction of recent high-throughput technologies to various fields of science and medicine, it is becoming clear that obtaining large amounts of data is no longer a problem in modern research laboratories. However, coherent study designs, optimal conditions for obtaining high-quality data, and compelling interpretation, in accordance with the evidence-based systems biology, are critical factors in ensuring the emergence of good science out of these recent technologies. This review focuses on the proteomics field and its new perspectives on cancer research. Cornerstone publications that have tremendously helped scientists and clinicians to better understand cancer pathogenesis; to discover novel diagnostic and/or prognostic biomarkers; and to suggest novel therapeutic targets will be presented. The author of this review aims at presenting some of the relevant literature data that helped as a step forward in bridging the gap between bench work results and bedside potentials. Undeniably, this review cannot include all the work that is being produced by expert research groups all over the world.
authors.affiliation: Clinical Chemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia ; Obesity Research Center, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia ; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
authors.forename: Reem M
authors.identifier: 0000-0002-5814-4811
authors.initials: RM
authors.lastname: Sallam
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D055088:Early Detection of Cancer / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis*; D040901:Proteomics / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor