title: Mesenchymal stromal cells and the innate immune response.
abstract: Mesenchymal stromal cells (MSC) have been exploited for their immunomodulatory properties in the treatment of a number of immune-based disorders, including Graft versus Host Disease (GvHD) and type 1 diabetes. The mechanisms for inducing therapeutic effect still remain largely unknown however, with research focused on understanding how MSCs interact with individual immune cell subsets. Within this review we address what is known about the interactions of MSCs with cells of the innate immune system, how they respond to their microenvironment and how this relates to therapeutic effects we see both within in vivo animal models and in clinical trials.
authors.affiliation: Center for Hematology and Regenerative Medicine, Department of Laboratory Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden; Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden. Electronic address: Katarina.Leblanc@ki.se.
authors.forename: Katarina
authors.initials: K
authors.lastname: Le Blanc
authors.affiliation: Center for Hematology and Regenerative Medicine, Department of Laboratory Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden; Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Lindsay C
authors.initials: LC
authors.lastname: Davies
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D060833:Cellular Microenvironment / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology*; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators
keywords: Immunomodulation; Inflammation; Innate immunity; Mesenchymal stromal cells