title: Spatial Tumor Heterogeneity in Lung Cancer with Acquired Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance: Targeting High-Level MET-Amplification and EGFR T790M Mutation Occurring at Different Sites in the Same Patient.
authors.affiliation: *Lung Cancer Group Cologne, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; †Center for Integrated Oncology Köln Bonn, Institute of Pathology, University Hospital of Cologne, Cologne, Germany; ‡Department of Translational Genomics, Center for Integrated Oncology Köln Bonn, University of Cologne, Cologne, Germany; §Lung Cancer Group Cologne, Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany; ‖Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital of Cologne, Cologne, Germany; ¶Center for Integrated Oncology Köln Bonn, Institute of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany; and #Institute of Hematopathology Hamburg, Hamburg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Scheffler
authors.forename: Sabine
authors.initials: S
authors.lastname: Merkelbach-Bruse
authors.forename: Marc
authors.initials: M
authors.lastname: Bos
authors.forename: Jana
authors.initials: J
authors.lastname: Fassunke
authors.forename: Masyar
authors.initials: M
authors.lastname: Gardizi
authors.forename: Sebastian
authors.initials: S
authors.lastname: Michels
authors.forename: Laura
authors.initials: L
authors.lastname: Groneck
authors.forename: Anne M
authors.initials: AM
authors.lastname: Schultheis
authors.forename: Florian
authors.initials: F
authors.lastname: Malchers
authors.forename: Frauke
authors.initials: F
authors.lastname: Leenders
authors.forename: Carsten
authors.initials: C
authors.lastname: Kobe
authors.forename: Katharina
authors.initials: K
authors.lastname: König
authors.forename: Lukas C
authors.initials: LC
authors.lastname: Heukamp
authors.forename: Martin L
authors.initials: ML
authors.lastname: Sos
authors.forename: Roman K
authors.initials: RK
authors.lastname: Thomas
authors.forename: Reinhard
authors.initials: R
authors.lastname: Büttner
authors.forename: Jürgen
authors.initials: J
authors.lastname: Wolf
mesh_terms: D019008:Drug Resistance, Neoplasm; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D005784:Gene Amplification; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009154:Mutation; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met