title: Aggressive Central Giant Cell Granuloma of the Mandible Treated With Conservative Surgical Enucleation and Interferon-α-2a: Complete Remission With Long-Term Follow-Up.
abstract: Central giant cell granuloma (CGCG) is a benign tumor of the jaws. Aggressive lesions present a strong tendency toward recurrence after surgical enucleation; thus, en bloc resection and microvascular bone free flap transfer are usually performed. However, in young patients, aggressive surgical treatment is a not always suitable solution. This report describes the case of a young female patient who developed an aggressive recurrence of CGCG after its diagnosis and enucleation from the mandible. Surgical enucleation with subcutaneous injection of interferon-α-2a was performed. The patient was evaluated every 6 weeks, and after 6 months radiographic evidence of complete bone regeneration was obtained. No sign of recurrence was seen after 8 years of follow-up. A review of the literature proved that interferon treatment is an effective strategy to avoid extensive surgery in patients with aggressive CGCG.
authors.affiliation: Researcher, Department of Biomedical and Neuromotor Sciences, Section of Maxillofacial Surgery, Policlinico Sant'Orsola-Malpighi, University of Bologna, Bologna, Italy.
authors.forename: Achille
authors.initials: A
authors.lastname: Tarsitano
authors.affiliation: PhD student, Department of Biomedical and Neuromotor Sciences, Section of Oral Science, University of Bologna, Bologna, Italy. Electronic address: giacomo.delcorso@unibo.it.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Del Corso
authors.affiliation: Medical Doctor, Department of Biomedical and Neuromotor Sciences, Section of Maxillofacial Surgery, Policlinico Sant'Orsola-Malpighi, University of Bologna, Bologna, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Pizzigallo
authors.affiliation: Professor of Oral and Maxillofacial Surgery, Department of Biomedical and Neuromotor Sciences, Section of Maxillofacial Surgery, Policlinico Sant'Orsola-Malpighi, University of Bologna, Bologna, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Marchetti
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006101:Granuloma, Giant Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008339:Mandibular Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery*; D011862:Radiography, Panoramic; D011994:Recombinant Proteins / Q000627:therapeutic use; D012074:Remission Induction
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins