title: B-cell-independent lymphoid tissue infection by a B-cell-tropic rhadinovirus.
abstract: Lymphocytes provide gammaherpesviruses with a self-renewing substrate for persistent infection and with transport to mucosal sites for host exit. Their role in the initial colonization of new hosts is less clear. Murid herpesvirus 4 (MuHV-4), an experimentally accessible, B-cell-tropic rhadinovirus (gamma-2 herpesvirus), persistently infects both immunocompetent and B-cell-deficient mice. A lack of B-cells did not compromise MuHV-4 entry into lymphoid tissue, which involved myeloid cell infection. However, it impaired infection amplification and MuHV-4 exit from lymphoid tissue, which involved myeloid to B-cell transfer.
authors.affiliation: Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.
authors.forename: Brittany
authors.initials: B
authors.lastname: Chao
authors.affiliation: Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.
authors.forename: Bruno
authors.initials: B
authors.lastname: Frederico
authors.affiliation: Sir Albert Sakzewski Virus Research Centre, Clinical Medical Virology Centre, School of Chemistry and Molecular Biosciences, Royal Children's Hospital and University of Queensland, Brisbane, Australia.|Division of Virology, Department of Pathology, University of Cambridge, Cambridge, UK.
authors.forename: Philip G
authors.initials: PG
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000821:virology*; D006566:Herpesviridae Infections / Q000662:veterinary* / Q000821:virology; D008221:Lymphoid Tissue / Q000821:virology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018144:Rhadinovirus / Q000235:genetics / Q000502:physiology*; D012376:Rodent Diseases / Q000821:virology*; D056189:Viral Tropism