title: Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.
abstract: In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ; School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
authors.forename: Shaobo
authors.initials: S
authors.lastname: Yao
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Kongzhen
authors.initials: K
authors.lastname: Hu
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Ganghua
authors.identifier: 0000-0003-2639-0388
authors.initials: G
authors.lastname: Tang
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Siyuan
authors.initials: S
authors.lastname: Gao
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Caihua
authors.initials: C
authors.lastname: Tang
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Baoguo
authors.initials: B
authors.lastname: Yao
authors.affiliation: Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Dahong
authors.initials: D
authors.lastname: Nie
authors.affiliation: Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Sun
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
authors.forename: Shende
authors.initials: S
authors.lastname: Jiang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D006801:Humans; D020287:In Situ Nick-End Labeling; D007275:Injections, Intravenous; D019169:Jurkat Cells; D008764:Methylmalonic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008819:Mice, Nude; D057054:Molecular Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D014018:Tissue Distribution
chemical_list: C000605037:2-(3-fluoropropyl)-2-methylmalonic acid; D008764:Methylmalonic Acid; D003520:Cyclophosphamide