title: [Immune regulation of cancer stem cells].
abstract: Emerging evidences have revealed the role of tumor-associated immune cells and their derivatives in the regulation of tumor progression. In particular, recent studies have clarified that various tumor-associated immune regulatory systems, which include tumor-infiltrating myeloid cells and pro-inflammatory cytokines, for regulating the maintenance and activation of cancer stem cells. The networks formed by immune cells and cancer stem cells play a critical role in further amplifying infiltration of pro-tumor immune cells and inflammatory cascades, and promoting cancer stemness. Further clarification about the immune-mediated regulation of cancer stem cell activities should provide therapeutic implication against cancer stem cells and treatment-resistant variants of cancer cells.
authors.forename: Masahisa
authors.initials: M
authors.lastname: Jinushi
mesh_terms: D016207:Cytokines / Q000276:immunology; D006801:Humans; D022423:Myeloid Cells / Q000276:immunology; D016328:NF-kappa B / Q000276:immunology / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000276:immunology*; D050796:STAT3 Transcription Factor / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D050796:STAT3 Transcription Factor