title: Arrhythmia in stem cell transplantation.
abstract: Stem cell regenerative therapies hold promise for treating diseases across the spectrum of medicine. While significant progress has been made in the preclinical stages, the clinical application of cardiac cell therapy is limited by technical challenges. Certain methods of cell delivery, such as intramyocardial injection, carry a higher rate of arrhythmias. Other potential contributors to the arrhythmogenicity of cell transplantation include reentrant pathways caused by heterogeneity in conduction velocities between graft and host as well as graft automaticity. In this article, the arrhythmogenic potential of cell delivery to the heart is discussed.
authors.affiliation: Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 100 UCLA Medical Plaza, Suite 630 East, Los Angeles, CA 90095, USA.
authors.forename: Shone O
authors.initials: SO
authors.lastname: Almeida
authors.affiliation: Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 100 UCLA Medical Plaza, Suite 630 East, Los Angeles, CA 90095, USA; Murdoch Children's Research Institute, The Royal Children's Hospital, Cardiac Development, 50 Flemington Road, Parkville, Victoria 3052, Australia.
authors.forename: Rhys J
authors.initials: RJ
authors.lastname: Skelton
authors.affiliation: Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 100 UCLA Medical Plaza, Suite 630 East, Los Angeles, CA 90095, USA.
authors.forename: Sasikanth
authors.initials: S
authors.lastname: Adigopula
authors.affiliation: Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 100 UCLA Medical Plaza, Suite 630 East, Los Angeles, CA 90095, USA; Eli and Edyth Broad Stem Cell Research Center, University of California, 675 Charles E Young Drive South, MRL Room 3780, Los Angeles, CA 90095, USA. Electronic address: rardehali@mednet.ucla.edu.
authors.forename: Reza
authors.initials: R
authors.lastname: Ardehali
mesh_terms: D001145:Arrhythmias, Cardiac; D006801:Humans; D032383:Myocytes, Cardiac; D033581:Stem Cell Transplantation
keywords: Arrhythmia; Cardiomyocyte; Coupling; Electromechanical; Paracrine; Regeneration; Stem cell