title: Preventive Effect of Cecropia pachystachya Against Ketamine-Induced Manic Behavior and Oxidative Stress in Rats.
abstract: Cecropia species are widely used in traditional medicine by its anti-diabetic, anti-hypertensive and anti-inflammatory properties. In the present study, we investigated the neuroprotective and antioxidant effects of the crude aqueous extract from Cecropia pachystachya leaves in a rat model of mania induced by ketamine. The results indicated that ketamine treatment (25 mg/kg i.p., for 8 days) induced hyperlocomotion in the open-field test and oxidative damage in prefrontal cortex and hippocampus, evaluated by increased lipid peroxidation, carbonyl protein formation and decreased total thiol content. Moreover, ketamine treatment reduced the activity of the antioxidant enzymes superoxide dismutase and catalase in hippocampus. Pretreatment of rats with C. pachystachya aqueous extract (200 and 400 mg/kg p.o., for 14 days) or with lithium chloride (45 mg/kg p.o., for 14 days, used as a positive control) prevented both behavioral and pro-oxidant effects of ketamine. These findings suggest that C. pachystachya might be a useful tool for preventive intervention in bipolar disorder, reducing the episode relapse and the oxidative damage associated with the manic phase of this disorder .
authors.affiliation: Programa de Pós-Graduação em Saúde e Comportamento, Centro de Ciências da Vida e da Saúde, Universidade Católica de Pelotas, Rua Gonçalves Chaves 373, Pelotas, RS, 96015560, Brazil.
authors.forename: Marta
authors.initials: M
authors.lastname: Gazal
authors.forename: Fernanda N
authors.initials: FN
authors.lastname: Kaufmann
authors.forename: Bruna A
authors.initials: BA
authors.lastname: Acosta
authors.forename: Pathise Souto
authors.initials: PS
authors.lastname: Oliveira
authors.forename: Matheus R
authors.initials: MR
authors.lastname: Valente
authors.forename: Caroline Flach
authors.initials: CF
authors.lastname: Ortmann
authors.forename: Régis
authors.initials: R
authors.lastname: Sturbelle
authors.forename: Claiton L
authors.initials: CL
authors.lastname: Lencina
authors.forename: Francieli M
authors.initials: FM
authors.lastname: Stefanello
authors.forename: Manuella P
authors.initials: MP
authors.lastname: Kaster
authors.forename: Flávio Henrique
authors.initials: FH
authors.lastname: Reginatto
authors.forename: Gabriele
authors.initials: G
authors.lastname: Ghisleni
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001714:Bipolar Disorder / Q000517:prevention & control*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D007649:Ketamine / Q000633:toxicity*; D008124:Locomotion / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D027003:Urticaceae / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D007649:Ketamine