title: The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine.
abstract: The CD300a inhibitory receptor belongs to the CD300 family of cell surface molecules that regulate a diverse array of immune cell processes. The inhibitory signal of CD300a depends on the phosphorylation of tyrosine residues embedded in ITIMs of the cytoplasmic tail. CD300a is broadly expressed on myeloid and lymphoid cells, and its expression is differentially regulated depending on the cell type. The finding that CD300a recognizes phosphatidylserine and phosphatidylethanolamine, two aminophospholipids exposed on the outer leaflet of dead and activated cells, has shed new light on its role in the modulation of immune functions and in its participation in the host response to several diseases states, such as infectious diseases, cancer, allergy, and chronic inflammatory diseases. This review summarizes the literature on CD300a expression, regulation, signaling pathways, and ligand interaction, as well as its role in fine tuning immune cell functions and its clinical relevance.
authors.affiliation: Immunopathology Group, BioCruces Health Research Institute, Barakaldo 48903, Spain;
authors.forename: Olatz
authors.initials: O
authors.lastname: Zenarruzabeitia
authors.affiliation: Immunopathology Group, BioCruces Health Research Institute, Barakaldo 48903, Spain;
authors.forename: Joana
authors.initials: J
authors.lastname: Vitallé
authors.affiliation: Cell Therapy and Stem Cell Group, Basque Center for Transfusion and Human Tissues, Galdakao 48960, Spain;
authors.forename: Cristina
authors.initials: C
authors.lastname: Eguizabal
authors.affiliation: Division of Biotechnology Review and Research-I, Office of Biotechnology Products Review and Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993; and.
authors.forename: Venkateswara R
authors.initials: VR
authors.lastname: Simhadri
authors.affiliation: Immunopathology Group, BioCruces Health Research Institute, Barakaldo 48903, Spain; Ikerbasque, Basque Foundation for Science 48903, Bilbao, Spain francisco.borregorabasco@osakidetza.eus pacoborregorabasco@gmail.com.
authors.forename: Francisco
authors.initials: F
authors.lastname: Borrego
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D061626:Immunoreceptor Tyrosine-Based Inhibition Motif / Q000235:genetics*; D008024:Ligands; D051379:Mice; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000037:antagonists & inhibitors*; D010718:Phosphatidylserines / Q000037:antagonists & inhibitors*; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014777:Virus Diseases / Q000235:genetics / Q000378:metabolism
chemical_list: D015703:Antigens, CD; C515070:CD300A protein, human; D008024:Ligands; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D011971:Receptors, Immunologic; C483858:phosphatidylethanolamine