title: [Effect of anti-helicobacter therapy on the hepatic glucuronyl transferase system of adolescents with Gilbert's syndrome].
abstract: Bilirubin biotransformation occurs with the participation of the glucuronyl transferase (GTF) system of the liver and hepatocyte membranes. Disturbances in these systems may result in a rise of blood bilirubin levels and disbalance between direct and indirect bilirubin leading to jaundice. Gilbert's syndrome (GS) is a genetic disorder associated with the enhanced level of indirect bilirubin due to GTF insufficiency.
  
  
  METHODS
  The study included adolescents aged 13.4 ± 0.42 yr divided into 2 groups depending on anti-Helicobacter therapy (AHBT). We measured levels of direct and indirect bilirubins, their ratio, and direct bilirubin content as percentage of total bilirubin at admission to and discharge from the hospital. The daily incremental growth of both bilirubin fractions was calculated
  
  
  RESULTS
  Detailed analysis revealed negative effect of AHBT on the GTF system attributable to its impaired stability in patients with abnormal genotype.
  
  
  CONCLUSIONS
  Prescription of AHBT to children with Gilbert's syndrome requires the thorough choice of medications and monitoring of their potential effect on the GFT system.
authors.forename: O K
authors.initials: OK
authors.lastname: Botvin'ev
authors.forename: A I
authors.initials: AI
authors.lastname: Kolotilina
authors.forename: I E
authors.initials: IE
authors.lastname: Turina
authors.forename: G M
authors.initials: GM
authors.lastname: Dubrovina
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001663:Bilirubin / Q000097:blood*; D005878:Gilbert Disease / Q000097:blood / Q000201:enzymology*; D014453:Glucuronosyltransferase / Q000187:drug effects*; D016998:Helicobacter / Q000187:drug effects; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D014453:Glucuronosyltransferase; D001663:Bilirubin