title: Indole Functionalization via Photoredox Gold Catalysis.
abstract: The use of photoredox catalyst [Au2(dppm)2]Cl2 to initiate free-radical cyclizations onto indoles is reported. Excitation of the dimeric Au(I) photocatalyst for the reduction of unactivated bromoalkanes and bromoarenes is used for the generation of carbon-centered radicals. Previous to this work, reduction processes leading to indole functionalization utilizing photoredox catalysts were limited to activated benzylic or α-carbonyl-positioned bromoalkanes. This method offers a mild and safe alternative to organostannanes and pyrophoric initiators for access to high energy radicals that were previously inaccessible through catalytic or stoichiometric means.
authors.affiliation: Centre for Catalysis, Research and Innovation, Department of Chemistry and Biomolecular Science, University of Ottawa, 10 Marie Curie, Ottawa K1N 6N5, Canada.
authors.forename: Sherif J
authors.initials: SJ
authors.lastname: Kaldas
authors.affiliation: Centre for Catalysis, Research and Innovation, Department of Chemistry and Biomolecular Science, University of Ottawa, 10 Marie Curie, Ottawa K1N 6N5, Canada.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Cannillo
authors.affiliation: Centre for Catalysis, Research and Innovation, Department of Chemistry and Biomolecular Science, University of Ottawa, 10 Marie Curie, Ottawa K1N 6N5, Canada.
authors.forename: Terry
authors.initials: T
authors.lastname: McCallum
authors.affiliation: Centre for Catalysis, Research and Innovation, Department of Chemistry and Biomolecular Science, University of Ottawa, 10 Marie Curie, Ottawa K1N 6N5, Canada.
authors.forename: Louis
authors.initials: L
authors.lastname: Barriault