title: miR-526a regulates apoptotic cell growth in human carcinoma cells.
abstract: MicroRNAs (miRNAs) play vital roles in the regulation of cell cycle, cell growth, apoptosis, and tumorigenesis. Our previous studies showed that miR-526a positively regulated innate immune response by suppressing CYLD expression, however, the functional relevance of miR-526a expression and cell growth remains to be evaluated. In this study, miR-526a overexpression was found to promote cancer cell proliferation, migration, and anchor-independent colony formation. The molecular mechanism(s) of miR-526a-mediated growth stimulation is associated with rapid cell cycle progression and inhibition of cell apoptosis by targeting CYLD. Taken together, these results provide evidence to show the stimulatory role of miR-526a in tumor migration and invasion through modulation of the canonical NF-κB signaling pathway.
authors.affiliation: Beijing Institute of Biotechnology, Beijing, 100850, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Yang
authors.forename: Cui
authors.initials: C
authors.lastname: Wang
authors.forename: Changzhi
authors.initials: C
authors.lastname: Xu
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Yan
authors.forename: Congwen
authors.initials: C
authors.lastname: Wei
authors.forename: Kai
authors.initials: K
authors.lastname: Guan
authors.forename: Shengli
authors.initials: S
authors.lastname: Ma
authors.forename: Ye
authors.initials: Y
authors.lastname: Cao
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.forename: Deyong
authors.initials: D
authors.lastname: Zou
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.forename: Buchang
authors.initials: B
authors.lastname: Zhang
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Ma
authors.forename: Zirui
authors.initials: Z
authors.lastname: Zheng
mesh_terms: D017209:Apoptosis; D002465:Cell Movement; D049109:Cell Proliferation; D000074749:Deubiquitinating Enzyme CYLD; D057809:HEK293 Cells; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: C000595033:MIRN526 microRNA, human; D035683:MicroRNAs; D016328:NF-kappa B; D025521:Tumor Suppressor Proteins; C409984:CYLD protein, human; D000074749:Deubiquitinating Enzyme CYLD