title: Serum IGFBP7 levels associate with insulin resistance and the risk of metabolic syndrome in a Chinese population.
abstract: Metabolic syndrome (MetS), one of the major public health concerns, is regarded as the "common soil" of incidence of common chronic diseases and may increase the risk of type 2 diabetes. The predominant underlying mechanism of MetS is insulin resistance (IR). Additionally, previous studies have indicated that IGFBP7 has high affinity of binding with insulin and might induce IR. The objective of this study was to firstly evaluate the associations of serum IGFBP7 levels with IR and MetS with a relatively large sample and population based design. In a population based MetS case-control study, HOMA-IR was used to evaluate the insulin sensitivity and serum IGFBP7 levels were determined with chemiluminescence-linked immunoassay. As a result, the subjects of MetS and IR had higher serum levels of IGFBP7 than control healthy subjects. High serum IGFBP7 levels increased the risk of MetS and IR. Serum IGFBP7 levels were also found to be significantly correlated with metabolic-associated parameters of Waist-to-hip ratio (WHR), HDL and LDL. These findings suggest that serum IGFBP7 levels are associated with IR and MetS, providing new insight into the mechanism of IR and Mets. IGFBP7 may be a potential interventional target for IR and Mets.
authors.affiliation: Department of Epidemiology &Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Laboratory, the second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, China.
authors.forename: Minliang
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Epidemiology &Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ling
authors.affiliation: Third Hospital of Xiaoshan, Hangzhou 311251, China.
authors.forename: Libing
authors.initials: L
authors.lastname: Cai
authors.affiliation: Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm SE-171 76, Sweden.
authors.forename: Harvest F
authors.initials: HF
authors.lastname: Gu
authors.affiliation: Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Epidemiology &Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China.
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China.
authors.forename: Maode
authors.initials: M
authors.lastname: Lai
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D016022:Case-Control Studies; D002681:China; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology*; D008875:Middle Aged; D011159:Population Surveillance; D012306:Risk
chemical_list: D015415:Biomarkers; D018969:Insulin-Like Growth Factor Binding Proteins; C102529:insulin-like growth factor binding protein-related protein 1