title: The Classification and Evolution of Enzyme Function.
abstract: Enzymes are the proteins responsible for the catalysis of life. Enzymes sharing a common ancestor as defined by sequence and structure similarity are grouped into families and superfamilies. The molecular function of enzymes is defined as their ability to catalyze biochemical reactions; it is manually classified by the Enzyme Commission and robust approaches to quantitatively compare catalytic reactions are just beginning to appear. Here, we present an overview of studies at the interface of the evolution and function of enzymes.
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.
authors.forename: Sergio
authors.initials: S
authors.lastname: Martínez Cuesta
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.
authors.forename: Syed Asad
authors.initials: SA
authors.lastname: Rahman
authors.affiliation: Department of Pathogen Molecular Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Furnham
authors.affiliation: European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom. Electronic address: thornton@ebi.ac.uk.
authors.forename: Janet M
authors.initials: JM
authors.lastname: Thornton
mesh_terms: D004798:Enzymes / Q000145:classification* / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular
chemical_list: D004798:Enzymes