title: Neoadjuvant chemotherapy in controlling lymph node metastasis for locally advanced gastric cancer in a Chinese population.
abstract: This study aimed to evaluate the efficacy of FOLFOX6, SOX and XELOX as neoadjuvant chemotherapy for advanced gastric cancer. The study retrospectively assessed clinicopathological data of patients who received a radical D2 gastrectomy for gastric cancer from January 2010 to January 2013.The patients were either not administered neoadjuvant chemotherapy (control) or were given FOLFOX6, SOX and XELOX prior to surgery. The metastatic rate was also higher for the control group compared with the three chemotherapy regimens in N2 station lymph nodes (P < 0.001). The SOX group had significantly lower metastatic total and N2 station lymph nodes than FOLFOX6 and XELOX (P < 0.01). The frequency of metastatic lymph nodes relative to total lymph nodes examined was 9.9, 6.6, 3.9 and 5.3% for control, FOLFOX6, SOX and XELOX groups, respectively. In conclusion, SOX may be the most effective of these treatments as preoperative chemotherapy for Chinese patients with advanced gastric cancer.
authors.affiliation: a Department of General Surgery, The First Affiliated Hospital , College of Medicine, Zhejiang University , China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Dong
authors.affiliation: a Department of General Surgery, The First Affiliated Hospital , College of Medicine, Zhejiang University , China.
authors.forename: Ji-Ren
authors.initials: JR
authors.lastname: Yu
authors.affiliation: a Department of General Surgery, The First Affiliated Hospital , College of Medicine, Zhejiang University , China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: a Department of General Surgery, The First Affiliated Hospital , College of Medicine, Zhejiang University , China.
authors.forename: Xiao-Sun
authors.initials: XS
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016022:Case-Control Studies; D017024:Chemotherapy, Adjuvant; D002681:China / Q000453:epidemiology; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000556:secondary / Q000601:surgery; D015996:Survival Rate
keywords: FOLFOX6; Gastric cancer; Neoadjuvant chemotherapy; SOX; XELOX