title: Preliminary discussion on the value of (18)F-FDG PET/CT in the diagnosis and early staging of non-mycosis fungoides/Sézary's syndrome cutaneous malignant lymphomas.
abstract: OBJECTIVE
  To discuss the value of (18)F-fluorodeoxyglucose-positron emission tomography ((18)F-PET/CT) scans in the diagnosis and early staging of non-mycosis fungoides/Sézary's syndrome cutaneous malignant lymphomas (non-MF/SS CML).
  
  
  METHODS
  A total of 18 cases with non-MF/SS CML, confirmed by pathology or on clinical grounds, were analyzed in this study. The sensitivity of CT and PET/CT scans in the diagnosis of primary skin lesions, as well as the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of CT and PET/CT scans in the diagnosis of lymph nodes (LNs) and other organs (except skin and LNs) were calculated.
  
  
  RESULTS
  The diagnostic sensitivity of CT and PET/CT scans in the diagnosis of primary skin lesions was 82.4% (14/17) and 100% (17/17), respectively. The diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of CT and PET/CT scans in the diagnosis of LN lesions were 55.6% (5/9), 88.9% (8/9), 72.2% (13/18), 83.3% (5/6), 66.7% (8/12), and 88.9% (8/9), 100% (9/9), 94.4% (17/18), 100% (8/8), 90.0% (9/10), respectively. The diagnostic value of the CT and PET/CT scans in the diagnosis of involvement of other organs, were 40.4% (2/5), 100% (13/13), 83.3 (15/18), 100% (2/2), 81.3% (13/16) and 80.6% (4/5), 100% (13/13), 94.4% (17/18), 100% (3/3), 92.9% (13/14), respectively.
  
  
  CONCLUSIONS
  (18)F-FDG PET/CT has high value in the diagnosis and early staging of non-MF/SS CMLs.
authors.affiliation: Southern Medical University, Guangzhou, Guangdong, PR China; Department of PET Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China. Electronic address: shaodan501@outlook.com.
authors.forename: Shao
authors.initials: S
authors.lastname: Dan
authors.affiliation: The First People's Hospital of Foshan, Foshan, Guangdong, PR China. Electronic address: onwaykung@163.com.
authors.forename: Gao
authors.initials: G
authors.lastname: Qiang
authors.affiliation: Department of PET Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China. Electronic address: wang_shuxia@outlook.com.
authors.forename: Wang
authors.initials: W
authors.lastname: Shu-Xia
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, PR China. Electronic address: cjr.lchh@vip.163.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Chang-Hong
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009182:Mycosis Fungoides; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012751:Sezary Syndrome / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000000981:diagnostic imaging; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: B-cell; Cutaneous; Fluorodeoxyglucose F18; Lymphoma; Multidetector computed tomography; Positron-emission tomography; T-cell