title: V-shaped ligand 1,3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane and manganese(II), cobalt(II) and copper(II) complexes: Synthesis, crystal structure, DNA-binding properties and antioxidant activities.
abstract: A V-shaped ligand 1,3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane (bebt) and its transition metal complexes, [Mn(bebt)(pic)2]·CH3OH (pic=picrate) 1, [Co(bebt)2](pic)22 and [Cu(bebt)2](pic)2·2DMF 3, have been synthesized and characterized. The coordinate forms of complexes 1 and 2 are basically alike, which can be described as six-coordinated distorted octahedron. The geometric structure around Cu(II) atom can be described as distorted tetrahedral in complex 3. The DNA-binding properties of the ligand bebt and complexes have been investigated by electronic absorption, fluorescence, and viscosity measurements. The results suggest that bebt and complexes bind to DNA via an intercalative binding mode and the order of the binding affinity is 1<2<3<bebt. The possible relations between the structure and DNA-binding properties are also discussed. Moreover, the complex 3 possess significant antioxidant activity against superoxide and hydroxyl radicals, and the scavenging effects of it are stronger than standard mannitol and vitamin C.
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, PR China. Electronic address: wuhuilu@163.com.
authors.forename: Huilu
authors.initials: H
authors.lastname: Wu
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, PR China.
authors.forename: Zaihui
authors.initials: Z
authors.lastname: Yang
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, PR China.
authors.forename: Hongping
authors.initials: H
authors.lastname: Peng
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, PR China.
authors.forename: Han
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, PR China.
authors.forename: Cuiping
authors.initials: C
authors.lastname: Wang
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, Gansu 730070, PR China.
authors.forename: Kaitong
authors.initials: K
authors.lastname: Wang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism; D002417:Cattle; D003035:Cobalt / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008345:Manganese / Q000737:chemistry*; D008968:Molecular Conformation; D013843:Thiazines / Q000737:chemistry*; D014783:Viscosity
chemical_list: D000975:Antioxidants; D056831:Coordination Complexes; D008024:Ligands; D013843:Thiazines; D003035:Cobalt; D008345:Manganese; D003300:Copper; D004247:DNA; C427203:calf thymus DNA
keywords: Antioxidant activity; Benzimidazole; Crystal structure; DNA-binding property; Transition metal complex