title: Antibiotic Prophylaxis in Autologous Vein Graft Reconstructions of the Lower Extremity.
abstract: BACKGROUND
  Different factors contribute to infection after arterial reconstructive surgery. Prophylactic antibiotic use during surgery is widespread, however, there is insufficient evidence to support the use of prophylactic antibiotics with autologous vein grafting. The aim of our study was to assess the effect of single-dose prophylactic antibiotics in patients undergoing autologous vein grafting.
  
  
  METHODS
  Patients undergoing arterial bypass reconstruction in the lower extremity between 2004 and 2012 were retrospectively screened for use of vein grafts. Patients receiving single-dose antibiotic prophylaxis (group 1) were compared with those not receiving prophylaxis (group 2).
  
  
  RESULTS
  Primary outcome was surgical site infection (SSI), and 142 patients were included. The SSI occurred in 22% of patients in group 1 and in 29% of patients in group 2 (P = .39; odds ratio: 1.46 confidence interval 95%: 0.61-3.47).
  
  
  CONCLUSIONS
  Results showed no significant effect from single-dose antibiotic prophylaxis on lowering the incidence of SSI.
authors.affiliation: Sint Lucas Andreas Ziekenhuis, Department of Vascular Surgery, Vascular Centre Amsterdam, Amsterdam, the Netherlands jeroenjongkind@hotmail.com.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Jongkind
authors.affiliation: Sint Lucas Andreas Ziekenhuis, Department of Vascular Surgery, Vascular Centre Amsterdam, Amsterdam, the Netherlands.
authors.forename: Çaĝdaş
authors.initials: Ç
authors.lastname: Ünlü
authors.affiliation: Onze Lieve Vrouwe Gasthuis, Department of Vascular Surgery, Vascular Centre Amsterdam, Amsterdam, the Netherlands.
authors.forename: Anco
authors.initials: A
authors.lastname: Vahl
authors.affiliation: Sint Lucas Andreas Ziekenhuis, Department of Vascular Surgery, Vascular Centre Amsterdam, Amsterdam, the Netherlands.
authors.forename: Tony
authors.initials: T
authors.lastname: Voorwinde
authors.affiliation: Sint Lucas Andreas Ziekenhuis, Department of Vascular Surgery, Vascular Centre Amsterdam, Amsterdam, the Netherlands.
authors.forename: Roos
authors.initials: R
authors.lastname: van Nieuwenhuizen
authors.affiliation: Sint Lucas Andreas Ziekenhuis, Department of Vascular Surgery, Vascular Centre Amsterdam, Amsterdam, the Netherlands Onze Lieve Vrouwe Gasthuis, Department of Vascular Surgery, Vascular Centre Amsterdam, Amsterdam, the Netherlands.
authors.forename: Jan
authors.initials: J
authors.lastname: Bosma
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D002444:Cefuroxime / Q000008:administration & dosage; D016009:Chi-Square Distribution; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D006801:Humans; D016015:Logistic Models; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D015999:Multivariate Analysis; D009426:Netherlands; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000009:adverse effects / Q000379:methods*; D012189:Retrospective Studies; D012307:Risk Factors; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000382:microbiology / Q000517:prevention & control*; D016896:Treatment Outcome; D058017:Vascular Grafting / Q000009:adverse effects / Q000379:methods*; D014680:Veins / Q000637:transplantation*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D008795:Metronidazole; D002444:Cefuroxime
keywords: antibiotics; infection; lower extremity; vascular reconstruction; venous bypass