title: Mitochondrial cardiomyopathy and related arrhythmias.
abstract: Mitochondrial dysfunction has been shown to be involved in the pathophysiology of arrhythmia, not only in inherited cardiomyopathy due to specific mutations in the mitochondrial DNA but also in acquired cardiomyopathy such as ischemic or diabetic cardiomyopathy. This article briefly discusses the basics of mitochondrial physiology and details the mechanisms generating arrhythmias due to mitochondrial dysfunction. The clinical spectrum of inherited and acquired cardiomyopathies associated with mitochondrial dysfunction is discussed followed by general aspects of the management of mitochondrial cardiomyopathy and related arrhythmia.
authors.affiliation: Lille University, Inserm U1011, European Genomic Institute for Diabetes, Place de Verdun-amphi J&K, Lille F-59045, France; Institut Pasteur de Lille, Boulevard Louis XV, Lille F-59019, France; Cardiovascular Explorations Department, University Hospital of Lille, Lille F-59000, France. Electronic address: david.montaigne@chru-lille.fr.
authors.forename: David
authors.initials: D
authors.lastname: Montaigne
authors.affiliation: Cardiovascular Explorations Department, University Hospital of Lille, Lille F-59000, France; Division of Cardiomyopathy, Department of Cardiology, University Hospital of Lille, Rue du Pr Laguesse, Lille F-59000, France.
authors.forename: Anju Duva
authors.initials: AD
authors.lastname: Pentiah
mesh_terms: D001145:Arrhythmias, Cardiac; D009202:Cardiomyopathies; D004272:DNA, Mitochondrial / Q000235:genetics; D006801:Humans; D028361:Mitochondrial Diseases; D009154:Mutation
chemical_list: D004272:DNA, Mitochondrial
keywords: Arrhythmia management; Arrhythmia mechanisms; Diabetic cardiomyopathy; Mitochondrial DNA mutation; Mitochondrial cardiomyopathy; Mitochondrial syndrome