title: Establishing a Nomogram for Stage IA-IIB Cervical Cancer Patients after Complete Resection.
abstract: BACKGROUND
  This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection with pelvic lymphadenectomy.
  
  
  METHODS
  This nomogram was based on a retrospective study on 1,563 stage IA-IIB cervical cancer patients who underwent complete resection and lymphadenectomy from 2002 to 2008. The nomogram was constructed based on multivariate analysis using Cox proportional hazard regression. The accuracy and discriminative ability of the nomogram were measured by concordance index (C-index) and calibration curve.
  
  
  RESULTS
  Multivariate analysis identified lymph node metastasis (LNM), lymph-vascular space invasion (LVSI), stromal invasion, parametrial invasion, tumor diameter and histology as independent prognostic factors associated with cervical cancer survival. These factors were selected for construction of the nomogram. The C-index of the nomogram was 0.71 (95% CI, 0.65 to 0.77), and calibration of the nomogram showed good agreement between the 5-year predicted survival and the actual observation.
  
  
  CONCLUSIONS
  We developed a nomogram predicting 5-year overall survival of surgically treated stage IA-IIB cervical cancer patients. More comprehensive information that is provided by this nomogram could provide further insight into personalized therapy selection.
authors.affiliation: Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China E-mail : dma@tjh.tjmu.edu.cn, lee5190008@126.com, chengxd001@163.com.
authors.forename: Hang
authors.initials: H
authors.lastname: Zhou
authors.forename: Xiong
authors.initials: X
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yao
authors.initials: Y
authors.lastname: Jia
authors.forename: Ting
authors.initials: T
authors.lastname: Hu
authors.forename: Ru
authors.initials: R
authors.lastname: Yang
authors.forename: Ke-Cheng
authors.initials: KC
authors.lastname: Huang
authors.forename: Zhi-Lan
authors.initials: ZL
authors.lastname: Chen
authors.forename: Shao-Shuai
authors.initials: SS
authors.lastname: Wang
authors.forename: Fang-Xu
authors.initials: FX
authors.lastname: Tang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.forename: Yi-Le
authors.initials: YL
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Han
authors.forename: Zhong-Qiu
authors.initials: ZQ
authors.lastname: Lin
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Lu
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.forename: Peng-Peng
authors.initials: PP
authors.lastname: Qu
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Cai
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Song
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Tian
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
authors.forename: Dan
authors.initials: D
authors.lastname: Liu
authors.forename: Ze-Hua
authors.initials: ZH
authors.lastname: Wang
authors.forename: Hong-Bing
authors.initials: HB
authors.lastname: Xu
authors.forename: Chang-Yu
authors.initials: CY
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Xi
authors.forename: Dong-Rui
authors.initials: DR
authors.lastname: Deng
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Lv
authors.forename: Keng
authors.initials: K
authors.lastname: Shen
authors.forename: Shi-Xuan
authors.initials: SX
authors.lastname: Wang
authors.forename: Xing
authors.initials: X
authors.lastname: Xie
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Cheng
authors.forename: Ding
authors.initials: D
authors.lastname: Ma
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy / Q000401:mortality*; D008197:Lymph Node Excision / Q000401:mortality*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D049451:Nomograms; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery