title: Synthesis and anti-inflammatory activity of new 1,2,4-triazole derivatives.
abstract: The series of new 1,2,4-triazole derivatives with methacrylic acid moiety were synthesized and characterized by NMR and IR spectroscopy as well as X-ray crystallography. The influence of newly synthesized compounds on the inflammation on the level of cytokine production and the proliferation of human peripheral blood mononuclear cells (PBMC) were experimentally evaluated. Obtained triazoles showed antiproliferative activity and diverse effects on cytokine production. Two compounds demonstrated potentially anti-inflammatory activity and comparable effects with ibuprofen.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Jurasza 2, 85-089 Bydgoszcz, Poland. Electronic address: renata.bursa@cm.umk.pl.
authors.forename: Renata
authors.initials: R
authors.lastname: Paprocka
authors.affiliation: Department of Immunology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wiese
authors.affiliation: Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Waszyngtona 13, 15-269 Bialystok, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Eljaszewicz
authors.affiliation: Department of Immunology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Helmin-Basa
authors.affiliation: Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Gzella
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Jurasza 2, 85-089 Bydgoszcz, Poland.
authors.forename: Bozena
authors.initials: B
authors.lastname: Modzelewska-Banachiewicz
authors.affiliation: Department of Immunology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, M. Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Michalkiewicz
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D018360:Crystallography, X-Ray; D016207:Cytokines / Q000096:biosynthesis; D015195:Drug Design; D006801:Humans; D066298:In Vitro Techniques; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D014230:Triazoles
keywords: Amidrazone; IL-10; IL-6; Ibuprofen; PBMC; Proliferation; TNF-α; Triazole