title: [Breast cancer stem cell research utilizing clinical specimens].
abstract: The existence of cancer stem cells in solid tumors was first reported in 2003 based on the analyses of human breast cancers. Analyses of clinical specimens are especially important for the advancement of human cancer stem cell research. For example, the analyses of breast cancer stem cells directly isolated from human breast cancer specimens identified the microRNAs that are involved in the regulation of human breast cancer stem cells. In addition, human breast cancer xenograft is an attractive model to analyze cancer stem cells, as well as cancer metastases that have profound effect on the long-term survival of breast cancer patients. We will present the current status of human breast cancer stem cell research that utilizes clinical specimens.
authors.forename: Junko
authors.initials: J
authors.lastname: Mukohyama
authors.forename: Yohei
authors.initials: Y
authors.lastname: Shimono
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000378:metabolism*; D012008:Recurrence; D057905:Stem Cell Research
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs