title: Congenital transmission of Trypanosoma cruzi in central Brazil. A study of 1,211 individuals born to infected mothers.
abstract: Transmission of Trypanosoma cruzi during pregnancy is estimated to occur in less than 20% of infected mothers; however, the etiopathogenesis is not completely understood. The Centre for Studies on Chagas Disease provides confirmation of T. cruzi infection for individuals living in central Brazil. In this retrospective hospital-based study, all requests for diagnosis of T. cruzi infection in individuals less than 21 years old from 1994-2014 were searched. We end with 1,211 individuals and their respective infected mothers. Congenital transmission of infection was confirmed in 24 individuals (2%) in central Brazil, an area where the main T. cruzi lineage circulating in humans is TcII. This low prevalence of congenital Chagas disease is discussed in relation to recent findings in the south region of Brazil, where TcV is the main lineage and congenital transmission has a higher prevalence (approximately 5%), similar to frequencies reported in Argentina, Paraguay and Bolivia. This is the first report to show geographical differences in the rates of congenital transmission of T. cruzi and the relationship between the prevalence of congenital transmission and the type of Tc prevalent in each region.
authors.affiliation: Núcleo de Estudos de Doença de Chagas, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Alejandro O
authors.initials: AO
authors.lastname: Luquetti
authors.affiliation: Núcleo de Estudos de Doença de Chagas, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Suelene Brito do Nascimento
authors.initials: SB
authors.lastname: Tavares
authors.affiliation: Núcleo de Estudos de Doença de Chagas, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Liliane da Rocha
authors.initials: Lda R
authors.lastname: Siriano
authors.affiliation: Núcleo de Estudos de Doença de Chagas, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Rozângela Amaral de
authors.initials: RA
authors.lastname: Oliveira
authors.affiliation: Núcleo de Estudos de Doença de Chagas, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Dayse Elizabeth
authors.initials: DE
authors.lastname: Campos
authors.affiliation: Núcleo de Estudos de Doença de Chagas, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Cicilio Alves
authors.initials: CA
authors.lastname: de Morais
authors.affiliation: Núcleo de Estudos de Doença de Chagas, Universidade Federal de Goiás, Goiânia, GO, Brasil.
authors.forename: Enio Chaves
authors.initials: EC
authors.lastname: de Oliveira
mesh_terms: D000293:Adolescent; D001938:Brazil / Q000453:epidemiology; D014355:Chagas Disease / Q000151:congenital* / Q000635:transmission*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data*; D008297:Male; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology*; D015995:Prevalence; D014349:Trypanosoma cruzi; D055815:Young Adult