title: Is self-reported adherence associated with clinical outcomes in women treated with anticholinergic medication for overactive bladder?
abstract: To determine the association between self-reported adherence to anticholinergic medication and clinical outcomes in women with overactive bladder (OAB).
  
  
  
  A prospective study of women with OAB treated with fesoterodine for 8 weeks. Adherence to medication was measured using the Medication Adherence Self-report Inventory (MASRI). A self reported adherence rate of ≥80% was considered adherent. The association between self-reported adherence and clinical outcomes (Global Index of Improvement, Global impression of Severity, urinary symptom and quality of life scores) was examined. We hypothesized that adherent women would have greater improvement in urinary symptoms and quality of life than non-adherent women.
  
  
  
  Based on the MASRI, 115 (62.5%) women were adherent and 69 (37.5%) were non-adherent to anticholinergic medication at 8weeks. Adherent women were more likely to report overall improvement in their symptoms compared to non-adherent women (84% vs. 24%, P < 0.001). Significantly more non-adherent women described their bladder symptoms as "moderate" or "severe" at 8 weeks compared to adherent women (74% vs. 44%, P = 0.03). At 8 weeks, adherent women reported significantly greater improvement (change) in urinary symptoms from baseline to 8 weeks than non-adherent women (-13.3 ± 25.8 vs. 2.5 ± 14.4, P = 0.04). Similarly, adherent women reported greater improvement in quality of life scores than non-adherent women (- 7.9 ± 24.0 vs. -1.8 ± 11.9, P = 0.003).
  
  
  
  Self-reported non-adherence, as measured by the MASRI, is associated with clinically meaningful outcomes in women with OAB. This further validates the MASRI as a clinically useful tool for measuring adherence to anticholinergic medications in women with OAB. Neurourol. Urodynam. 35:738-742, 2016. © 2015 Wiley Periodicals, Inc.
authors.forename: Uduak U
authors.initials: UU
authors.lastname: Andy
authors.affiliation: Division of Urogynecology, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Lily A
authors.initials: LA
authors.lastname: Arya
authors.affiliation: Division of Urology, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Ariana L
authors.initials: AL
authors.lastname: Smith
authors.affiliation: Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Propert
authors.affiliation: Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Hillary R
authors.initials: HR
authors.lastname: Bogner
authors.affiliation: Division of Urogynecology, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Kristen
authors.initials: K
authors.lastname: Colavita
authors.affiliation: Division of Urogynecology, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
authors.forename: Heidi S
authors.initials: HS
authors.lastname: Harvie
mesh_terms: D000368:Aged; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D055118:Medication Adherence; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use*; D011788:Quality of Life; D057566:Self Report; D016896:Treatment Outcome; D053201:Urinary Bladder, Overactive / Q000188:drug therapy*; D064804:Urological Agents / Q000627:therapeutic use*
chemical_list: D001559:Benzhydryl Compounds; D018727:Muscarinic Antagonists; D064804:Urological Agents; C526675:fesoterodine
keywords: OAB; adherence; anticholinergic