title: Blood donors--Serious adverse reactions (SAR) 2010-2014 EFS Châteauroux, France.
abstract: BACKGROUND
  In 2013, the national French incidence of serious adverse reactions (SAR) was 155.7 per 100,000 donations and 82% of SAR were grade 2 (French classification of SAR related to blood donors)
  
  
  OBJECTIVE
  The purpose of our study was to describe the profile of blood donator candidate which had a SAR in our center.
  
  
  METHODS
  The study contains all the SAR superior to grade 1 occurred on the site EFS Châteauroux (site and mobile blood collection) from January 2010 to October 31, 2014. We analyzed 37 parameters from the e-fit files (e-site French blood vigilance) and In-log software.
  
  
  RESULTS
  We identified 82 SAR for 72,553 blood donations (incidence: 113.02 SAR per 100,000 donations). Forty-one men and 41 women, middle age 39 years (18-66). Average height: 1.68 m (1.49-1.85); average weight: 68 kg (50-98); body mass index (kg/m(2)): 24,13(18.6-31.9). All donors were Caucasian and 30% unemployed. We found 74 vasovagal syncope (VVS), 5 hematomas, 2 arterial injuries and an adverse reaction to citrate. In 90%, the SAR was immediate and of grade 2 in 85% of cases. Thirty-seven percent of SAR were first donation in connection with whole blood in 87% of cases. Regarding the seniority of donors, the number of average donations (whole blood, plasma, platelets) was 16.5. An SAR determined the stop of blood donation in 65% of cases with nearly 80% stoppage if it was a first donation. Seventy-three percent of SAR as a VVS took place during blood collection or within 5 minutes following the end of the donation. Sixty-one percent were men. Forty-four percent of cases were a first donation and 83% occurred in mobile blood collection. Average age was 36 years. The result was a permanent stop of all type of donations in 76% of cases. Twenty-seven percent of SAR as a VVS took place beyond 5 minutes after the end of the donation. Seventy-five percent were women. Thirty percent of cases were a first donation and 95% of SAR occurred in mobile blood collection. Average age was 42 years. The result was a permanent stop of all type of donations in 40% of cases.
  
  
  CONCLUSIONS
  When the SAR as a VVS occurs during or within 5 minutes following the end of the donation, it leads to a permanent stop of any type of donation in 76% of cases.
authors.affiliation: EFS centre-Atlantique de Châteauroux, Châteauroux, France. Electronic address: alexandre.riga@efs.sante.fr.
authors.forename: A
authors.initials: A
authors.lastname: Riga
authors.affiliation: EFS centre-Atlantique de Châteauroux, Châteauroux, France; EFS centre-Atlantique de Bourges, Bourges, France. Electronic address: thierry.sapey@efs.sante.fr.
authors.forename: T
authors.initials: T
authors.lastname: Sapey
authors.affiliation: EFS centre-Atlantique de Châteauroux, Châteauroux, France. Electronic address: Melanie.bacanu@efs.sante.fr.
authors.forename: M
authors.initials: M
authors.lastname: Bacanu
authors.affiliation: EFS centre-Atlantique d'Orléans, Orléans, France. Electronic address: Jean-yves.py@efs.sante.fr.
authors.forename: J-Y
authors.initials: JY
authors.lastname: Py
authors.affiliation: EFS centre-Atlantique de Tours, Tours, France. Electronic address: Frederic.dehaut@efs.sante.fr.
authors.forename: F
authors.initials: F
authors.lastname: Dehaut
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001781:Blood Component Removal / Q000009:adverse effects*; D001782:Blood Donors / Q000706:statistics & numerical data*; D001803:Blood Transfusion; D005260:Female; D005602:France; D006406:Hematoma / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D019462:Syncope, Vasovagal / Q000209:etiology; D055815:Young Adult
keywords: Adverse reactions; Blood donors; Donation time course; Donneurs de sang; Donor vigilance; Malaise vagal; Mauvaise réaction; Moment du don; Vasovagal syncope; Vigilance donneur