title: Noninvasive Ventilation in Mustard Airway Diseases.
abstract: BACKGROUND
  Noninvasive ventilation (NIV) has been shown to improve numerous clinical measures in subjects with COPD, including gas exchange, exercise tolerance, dyspnea, hospitalizations, health-related quality of life (HRQOL), and functional status. Although useful for classical COPD, NIV has not been validated specifically as a treatment option for mustard airway disease. Our aim was to assess the efficacy of NIV in subjects with severe mustard airway disease.
  
  
  METHODS
  This study was performed over the course of 12 months on 20 subjects with severe mustard airway disease (Global Initiative for Chronic Obstructive Lung Disease criteria). Subjects were selected from the pulmonary clinic of Baqiyatallah Hospital in Tehran, Iran. Body mass index, lung function, dyspnea, exercise tolerance, HRQOL, sleep quality, and hospitalization measures were assessed before and after NIV treatment.
  
  
  RESULTS
  NIV improved HRQOL (P = .03) and sleep quality (P = .06) in very severe subjects and reduced hospitalizations (P = .003) and exacerbations (P = .01) in severe subjects. Chest imaging studies showed that these subjects had heterogeneous airway disease, the main finding of which was bronchiolitis obliterans.
  
  
  CONCLUSIONS
  NIV can be used as an effective new palliative method in the treatment of mustard airway disorders. Subjects with very severe and severe disease benefitted differently from NIV.
authors.affiliation: Respiratory Diseases Research Center, Janbazan Medical and Engineering Research Center, Tehran, Iran. Pulmonary Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Rasoul
authors.initials: R
authors.lastname: Aliannejad
authors.affiliation: Respiratory Diseases Research Center, Janbazan Medical and Engineering Research Center, Tehran, Iran. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Peyman
authors.affiliation: Respiratory Diseases Research Center, Janbazan Medical and Engineering Research Center, Tehran, Iran. Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. mghaneister@gmail.com m.ghanei@bmsu.ac.ir.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Ghanei
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001989:Bronchiolitis Obliterans / Q000000981:diagnostic imaging / Q000209:etiology; D002619:Chemical Warfare Agents / Q000633:toxicity*; D017079:Exercise Tolerance; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009151:Mustard Gas / Q000633:toxicity*; D063087:Noninvasive Ventilation / Q000706:statistics & numerical data*; D010166:Palliative Care / Q000379:methods; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D011788:Quality of Life; D011859:Radiography; D012890:Sleep; D016896:Treatment Outcome
chemical_list: D002619:Chemical Warfare Agents; D009151:Mustard Gas
keywords: bronchiolitis obliterans; chronic obstructive respiratory disease (COPD); noninvasive ventilation (NIV); sulfur mustard