title: Meta-analysis of C242T polymorphism in CYBA genes: risk of acute coronary syndrome is lower in Asians but not in Caucasians.
abstract: BACKGROUND
  A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome (ACS). However, the results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine the relationship between C242T polymorphism and ACS.
  
  
  RESULTS
  We screened PubMed/MEDLINE, EBSCIO, and EMBASE research reports until Mar. 2014 and extracted data from 10 studies involving 6102 ACS patients and 8669 controls. Subgroup analysis by ethnicity documented a significant decreased risk of ACS for C242T polymorphism in the Asian population under allelic comparison (odd ratio (OR) 0.73; 95% confidence intervals (CI) 0.64-0.83), dominant model (OR 0.71; 95% CI 0.62-0.82), and homozygote comparison (OR 0.57; 95% CI 0.35-0.92). However, in the overall population and especially with Caucasians, no significant association was uncovered. Further meta-regression analysis revealed that the heterogeneity among studies was largely attributed to ethnicity. No publication bias was detected through a funnel plot and an Egger's linear regression test.
  
  
  CONCLUSIONS
  Taken together, our results suggest that the C242T polymorphism might be a protective factor against developing ACS in the Asian population. Further researches will be needed to identify the confounding factors which modified the protective effect of T allele among Caucasians.
authors.affiliation: Key Laboratory for Diagnosis and Treatment of Cardiovascular Disease of Zhejiang Province, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
authors.forename: Po
authors.initials: P
authors.lastname: Hu
authors.forename: Ming-yuan
authors.initials: MY
authors.lastname: Huang
authors.forename: Xin-yang
authors.initials: XY
authors.lastname: Hu
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Xie
authors.forename: Mei-xiang
authors.initials: MX
authors.lastname: Xiang
authors.forename: Xian-bao
authors.initials: XB
authors.lastname: Liu
authors.forename: Jian-an
authors.initials: JA
authors.lastname: Wang
mesh_terms: D054058:Acute Coronary Syndrome / Q000208:ethnology* / Q000235:genetics*; D000483:Alleles; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D016014:Linear Models; D008297:Male; D019255:NADPH Oxidases / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D012107:Research Design; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D019255:NADPH Oxidases; C086986:CYBA protein, human
keywords: Acute coronary syndrome; C242T polymorphism; CYBA