title: S100B and ADMA in cerebral small vessel disease and cognitive dysfunction.
abstract: BACKGROUND
  Glial cell activation and endothelial dysfunction are thought to contribute to the pathophysiology of cerebral small vessel disease (SVD). The purpose of the present study was to determine if levels of S100B, a protein highly expressed in glial cells, and asymmetric dimethylarginine (ADMA), which promotes endothelial dysfunction, are elevated in the serum of patients with SVD and correlate with their cognitive functioning.
  
  
  METHODS
  The serum levels of S100B and ADMA were measured with enzyme-linked immunosorbent assays in 210 patients with SVD and 207 controls. Cognitive functioning was evaluated using the Montreal Cognitive Assessment. SVD lesions were categorized as isolated lacunar infarcts (ILI), multiple lacunar infarcts, leukoaraiosis (LA), and LA with cerebral atrophy using magnetic resonance imaging.
  
  
  RESULTS
  SVD patients were significantly older, and more likely to have hypertension, diabetes, and heart disease, and smoke compared to controls (Ps<0.05). Plasma levels of S100B and ADMA were significantly higher in SVD patients (Ps<0.05), though only S100B was significant after adjusting for the confounding factors. Subtype analyses indicated that ADMA levels were differentially altered depending on lesion type, particularly in cases with ILI and LA (Ps<0.05). Compared with controls, SVD patients had significant cognitive impairment that was most profound in the cases with LA (all Ps<0.05). Levels of S100B and ADMA were significantly correlated with cognitive decline in patients with LA (P<0.05).
  
  
  CONCLUSIONS
  S100B and ADMA are elevated in SVD, and are associated with cognitive impairment in patients with LA lesions.
authors.affiliation: Department of Geriatrics, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; Key Laboratory of Myocardial Ischemia Mechanism and Treatment Ministry, Harbin 150086, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Gao
authors.affiliation: Department of Geriatrics, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: fanyingyan@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Fan
authors.affiliation: Department of Neurosurgery, Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
authors.forename: Lu-Yan
authors.initials: LY
authors.lastname: Mu
authors.affiliation: Department of Geriatrics, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.affiliation: Department of Geriatrics, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Song
authors.affiliation: Department of Geriatrics, Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address: yinazhlu@163.com.
authors.forename: Yi-Na
authors.initials: YN
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D059345:Cerebral Small Vessel Diseases / Q000097:blood* / Q000175:diagnosis / Q000523:psychology*; D003072:Cognition Disorders / Q000097:blood* / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D016037:Single-Blind Method
chemical_list: D015415:Biomarkers; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; C018524:N,N-dimethylarginine; D001120:Arginine
keywords: ADMA; Cerebral small vessel disease; Cognitive dysfunction; S100B