title: Age-adjusted glycated albumin accurately reflects blood glucose in patients with neonatal diabetes mellitus: comparison with calculated glycated albumin determined by past blood glucose concentrations.
abstract: BACKGROUND
  Glycated albumin is a useful glycaemic control indicator for neonatal diabetes mellitus. However, glycated albumin concentrations in infants are lower than those in adults and increase in an age-dependent manner. Based on our investigation of non-diabetic subjects, we proposed the possibility that the reference range for adults may be used regardless of age, provided that age-adjusted glycated albumin is employed. In the present study, we evaluate the usefulness of age-adjusted glycated albumin in neonatal diabetes mellitus patients.
  
  
  METHODS
  Six neonatal diabetes mellitus patients (four patients with permanent neonatal diabetes mellitus and two patients with transient neonatal diabetes mellitus) were included. Measured glycated albumin or age-adjusted glycated albumin was compared to calculated glycated albumin, which was determined using calculation formulae we had reported based on past blood glucose over the 50 days before measurement of glycated albumin.
  
  
  RESULTS
  Measured glycated albumin was significantly lower than calculated glycated albumin (20.5 ± 4.9% versus 28.2 ± 6.1%; p < 0.0001), whereas age-adjusted glycated albumin was equivalent to calculated glycated albumin, showing no significant difference (27.5 ± 6.8% versus 28.2 ± 6.1%). Measured glycated albumin concentrations in patients with transient neonatal diabetes mellitus in remission were lower than the reference range for adults, whereas age-adjusted glycated albumin concentrations were within the reference range for adults.
  
  
  CONCLUSIONS
  We demonstrated that age-adjusted glycated albumin concentrations were consistent with calculated glycated albumin. Age-adjusted glycated albumin is therefore a useful glycaemic control indicator for neonatal diabetes mellitus patients.
authors.affiliation: Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan shige5p@asahikawa-med.ac.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Suzuki
authors.affiliation: Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Furuya
authors.affiliation: Department of Pediatrics, Sapporo Tokushukai Hospital, Sapporo, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Oshima
authors.affiliation: Department of Pediatrics, Sapporo Tokushukai Hospital, Sapporo, Japan Amamiya Shounika Clinic, Sapporo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Amamiya
authors.affiliation: Department of Neonatology, Japanese Red Cross Medical Center, Tokyo, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakao
authors.affiliation: Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center, Kobe, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Wada
authors.affiliation: Department of Pediatrics, Tenshi Hospital, Sapporo, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Okuhara
authors.affiliation: Department of Pediatrics, Anjo Kosei Hospital, Anjo, Japan Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayano
authors.affiliation: Department of Pediatrics and Perinatology, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Imamoto
authors.affiliation: Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Kumihiro
authors.initials: K
authors.lastname: Matsuo
authors.affiliation: Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tanahashi
authors.affiliation: Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Azuma
authors.affiliation: Department of Internal Medicine, Kawanishi City Hospital, Kawanishi, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Koga
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood*; D001774:Blood Chemical Analysis / Q000379:methods*; D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D017127:Glycation End Products, Advanced; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012709:Serum Albumin / Q000032:analysis*; D000093423:Glycated Serum Albumin
chemical_list: D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
keywords: Neonatal diabetes mellitus; glycaemic control indicator; glycated albumin