title: The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer's disease and mild-to-moderate Alzheimer's disease: a meta-analysis.
abstract: Alzheimer's disease (AD) is a devastating neurodegenerative disease and there is no effective therapy for it. Peroxisome proliferators activated receptor-gamma (PPAR-γ) agonists is a promising therapeutic approach for AD and has been widely studied recently, but no consensus was available up to now. To clarify this point, a meta-analysis was performed. We searched MEDLINE, EMBASE, Cochrane Central database, PUBMED, Springer Link database, SDOS database, CBM, CNKI and Wan fang database by December 2014. Standardized mean difference (SMD), relative risk (RR) and 95% confidence interval (CI) were calculated to assess the strength of the novel therapeutics for AD and mild-to-moderate AD. A total of nine studies comprising 1314 patients and 1311 controls were included in the final meta-analysis. We found the effect of PPAR-γ agonists on Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) scores by using STATA software. There was no evidence for obvious publication bias in the overall meta-analysis. There is insufficient evidence of statistically incognition of AD and mild-to-moderate AD patients have been improved who were treated with PPAR-γ agonists in our research. However, PPAR-γ agonists may be a promising therapeutic approach in future, especially pioglitazone, with large-scale randomized controlled trials to confirm.
authors.affiliation: a Department of Pharmacy, Anhui Cancer Hospital , Hefei , China.
authors.forename: Huawei
authors.initials: H
authors.lastname: Cheng
authors.affiliation: a Department of Pharmacy, Anhui Cancer Hospital , Hefei , China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Shang
authors.affiliation: b Department of Pharmacy, Anhui Provincial Hospital , Hefei , China.
authors.forename: Ling
authors.initials: L
authors.lastname: Jiang
authors.affiliation: b Department of Pharmacy, Anhui Provincial Hospital , Hefei , China.
authors.forename: Tian-lu
authors.initials: TL
authors.lastname: Shi
authors.affiliation: c Clinical Laboratory, the First Affiliated Hospital of Anhui University of Chinese Medicine , Hefei , China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism*; D001562:Benzimidazoles / Q000627:therapeutic use*; D001565:Benzoates / Q000627:therapeutic use*; D006801:Humans; D047495:PPAR gamma / Q000819:agonists*; D000077205:Pioglitazone; D000077154:Rosiglitazone; D000077333:Telmisartan; D045162:Thiazolidinediones / Q000627:therapeutic use*
chemical_list: D001562:Benzimidazoles; D001565:Benzoates; D047495:PPAR gamma; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D000077333:Telmisartan; D000077205:Pioglitazone
keywords: Alzheimer's disease; PPAR-γ agonists; meta-analysis