title: Idiopathic or iatrogenic membranous glomerulonephritis? A case of spironolactone-induced membranous glomerulonephritis.
abstract: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults in the UK. In most cases, the aetiology remains unknown, although recent data suggested a clear mechanism of pathogenesis. In approximately a quarter of cases, however, a presumed cause is found, such as systemic lupus nephritis, malignancy, hepatitis B and various drugs. Here, we present a patient who developed MN soon after commencing spironolactone and whose condition persisted for the duration of exposure to the drug only to resolve with cessation of the drug. No cases of spironolactone-induced MN have been reported in the literature previously.
authors.affiliation: Department of Renal Medicine, Manchester Royal Infirmary, Manchester, UK.
authors.forename: Akimichi
authors.initials: A
authors.lastname: Inaba
authors.affiliation: Department of Renal Medicine, Manchester Royal Infirmary, Manchester, UK.
authors.forename: Milind
authors.initials: M
authors.lastname: Nikam
authors.affiliation: Department of Renal Medicine, Manchester Royal Infirmary, Manchester, UK.
authors.forename: Colin
authors.initials: C
authors.lastname: Short
authors.affiliation: Department of Renal Medicine, Manchester Royal Infirmary, Manchester, UK.
authors.forename: Michael
authors.initials: M
authors.lastname: Venning
keywords: glomerulonephritis; membranous; nephropathy; spironolactone