title: Cutaneous siderosis secondary to intramuscular iron dextran treated with 755 nm Q-switched alexandrite laser: A case report.
abstract: BACKGROUND
  Cutaneous siderosis is accumulation of iron in the dermis and the subcutaneous tissue secondary to extravasation of an intramuscular or intravascular iron injection. It presents as varying shades of brown macules with no distinct contours. The hyperpigmentation is permanent without treatment.
  
  
  OBJECTIVE
  Q-switched lasers have been used effectively to treat lentigines and tattoos however, there is little data on the treatment of cutaneous siderosis with lasers. Our objective was to effectively treat cutaneous siderosis with a Q-switched alexandrite laser.
  
  
  RESULTS
  A 50-year-old female had received nine injections of intramuscular iron dextran, one injection every 2 weeks alternating right buttock and left buttock over the course of 5 months. A couple of weeks after her 9th injection which was on the left, she noted brown hyperpigmentation in the injection area with the left worse than the right. She waited 3 months for the hyperpigmentation to self-resolve before presenting in our clinic. We utilized the Q-switched alexandrite laser to treat the patient with a test spot. One week later, there was nice partial clearance from the test spot so we commenced full treatment of the hyperpigmentation. There was significant improvement after the first treatment and she has been treated 4 times with continued improvement over the past 2 months.
  
  
  CONCLUSIONS
  The Q-switched alexandrite laser is a useful tool in the treatment of cutaneous siderosis secondary to iron injection.
authors.affiliation: Scripps Clinic, La Jolla, California, 92037.
authors.forename: Amanda A
authors.initials: AA
authors.lastname: Lloyd
authors.affiliation: Scripps Clinic, La Jolla, California, 92037.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Graves
authors.affiliation: Scripps Clinic, La Jolla, California, 92037.
authors.forename: Edward V
authors.initials: EV
authors.lastname: Ross
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy; D005260:Female; D006397:Hematinics / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced / Q000601:surgery*; D007273:Injections, Intramuscular; D007505:Iron-Dextran Complex / Q000008:administration & dosage / Q000009:adverse effects*; D053685:Laser Therapy; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008875:Middle Aged; D012806:Siderosis / Q000209:etiology / Q000601:surgery*
chemical_list: D006397:Hematinics; D007505:Iron-Dextran Complex
keywords: deposition; hyperpigmentation; skin; staining of skin