title: New N,N,N',N'-tetradentate Pyrazoly Agents: Synthesis and Evaluation of their Antifungal and Antibacterial Activities.
abstract: A new library of N,N,N',N' -tetradentate pyrazoly compounds containing a pyrazole moiety was synthesized by the condensation of (3,5-dimethyl-1H-pyrazol-1-yl)methanol 2a or (1H-pyrazol-1-yl)methanol 2b with a series of primary diamines in refluxed acetonitrile for 6h. The antifungal activity against the budding yeast Saccharomyces cerevisiae, as well as the antibacterial activity against Escherichia coli of these new tetradentate ligands were studied. We found that these tetradentate ligands act specifically as antifungal agents and lack antibacterial activity. Their biological activities depend on the nature of the structure of the compounds.
authors.affiliation: Medical Biology Unit, Faculty of Medicine and Pharmacy of Oujda, University Mohammed the First, Oujda, Morocco. abrigach.farid@live.fr.
authors.forename: Farid
authors.initials: F
authors.lastname: Abrigach
authors.forename: Btissam
authors.initials: B
authors.lastname: Bouchal
authors.forename: Olivier
authors.initials: O
authors.lastname: Riant
authors.forename: Yohan
authors.initials: Y
authors.lastname: Macé
authors.forename: Abdelilah
authors.initials: A
authors.lastname: Takfaoui
authors.forename: Smaail
authors.initials: S
authors.lastname: Radi
authors.forename: Abdelouahad
authors.initials: A
authors.lastname: Oussaid
authors.affiliation: Medical Biology Unit, Faculty of Medicine and Pharmacy of Oujda, University Mohammed the First, Oujda, Morocco. bmbellaoui@gmail.com.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Bellaoui
authors.forename: Rachid
authors.initials: R
authors.lastname: Touzani
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003959:Diamines; D011720:Pyrazoles