title: A Transgenic Drosophila melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven Transformation In Vivo.
abstract: Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator (Tax-1) contributes to leukemogenesis via NF-κB. We describe transgenic Drosophila models expressing Tax in the compound eye and plasmatocytes. We demonstrate that Tax-1 but not Tax-2 induces ommatidial perturbation and increased plasmatocyte proliferation and that the eye phenotype is dependent on Kenny (IKKγ/NEMO), thus validating this new in vivo model.
authors.affiliation: Department of Experimental Pathology, Immunology, and Microbiology Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Margret
authors.initials: M
authors.lastname: Shirinian
authors.affiliation: Department of Biology, American University of Beirut, Beirut, Lebanon.
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Kambris
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, Lebanon.
authors.forename: Lama
authors.initials: L
authors.lastname: Hamadeh
authors.affiliation: Department of Molecular Biology, Umea University, Umea, Sweden.
authors.forename: Caroline
authors.initials: C
authors.lastname: Grabbe
authors.affiliation: Equipe Oncogenèse Rétrovirale, Lyon, France Equipe Labellisée, Ligue Nationale Contre le Cancer, Lyon, France Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, Lyon, France INSERM U1111 Ecole Normale Supérieure de Lyon, Lyon, France Université Lyon 1, LabEx ECOFECT-Eco-Evolutionary Dynamics of Infectious Diseases, Lyon, France.
authors.forename: Chloé
authors.initials: C
authors.lastname: Journo
authors.affiliation: Equipe Oncogenèse Rétrovirale, Lyon, France Equipe Labellisée, Ligue Nationale Contre le Cancer, Lyon, France Centre International de Recherche en Infectiologie, INSERM U1111-CNRS UMR5308, Lyon, France INSERM U1111 Ecole Normale Supérieure de Lyon, Lyon, France Université Lyon 1, LabEx ECOFECT-Eco-Evolutionary Dynamics of Infectious Diseases, Lyon, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: Mahieux
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut, Lebanon bazarbac@aub.edu.lb.
authors.forename: Ali
authors.initials: A
authors.lastname: Bazarbachi
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism / Q000821:virology*; D005123:Eye / Q000473:pathology / Q000821:virology; D016356:Gene Products, tax / Q000235:genetics / Q000378:metabolism*; D015490:HTLV-I Infections / Q000821:virology*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000502:physiology*; D015367:Human T-lymphotropic virus 2 / Q000235:genetics / Q000378:metabolism; D006801:Humans
chemical_list: D016356:Gene Products, tax; C514970:tax protein, Human T-lymphotrophic virus 1; C514971:tax protein, Human T-lymphotrophic virus 2