title: The Relationship between Retinol-Binding Protein 4 Concentrations and Gestational Diabetes Mellitus in Chinese Women.
abstract: BACKGROUND
  This study aimed to investigate the relationship between retinol-binding protein 4 (RBP4) and gestational diabetes mellitus (GDM).
  
  
  METHODS
  Seventy-six women with and without GDM were recruited. Their blood samples were collected to detect RBP4, fasting plasma glucose (FPG), fasting insulin (Fins), triglyceride (TG), total cholesterol (TC), low-density lipoprotein, high-density lipoprotein (HDL) and glycosylated hemoglobin (HbA1c) levels.
  
  
  RESULTS
  RBP4 (21.42 ± 3.846 vs. 39.08 ± 8.293 μg/ml), FPG, Fins, homeostasis model assessment of insulin resistance (HOMA-IR), HbA1c, and TG levels were higher, while HDL levels were lower in women with GDM (p < 0.01). In healthy controls, RBP4 concentrations were positively correlated with HOMA-IR and TG and inversely correlated with FPG and HDL (p < 0.05). Serum concentrations of RBP4 in women with GDM were inversely correlated with TC and positively correlated with maternal weight gain during pregnancy (p < 0.05). The ROC curve was drawn with a correct rate of 93.4%.
  
  
  CONCLUSIONS
  Concentrations of serum RBP4 were significantly higher in women with GDM, suggesting that elevated RPB4 level may play a role in the pathogenesis of GDM. Meanwhile, RBP4 might be a good predictor of GDM. RBP4 is correlated with TG and HDL, indicating that RBP4 plays a role in alterations of lipid metabolism in pregnant women. © 2015 S. Karger AG, Basel.
authors.affiliation: Women's Hospital, School of Medicine, and Key Laboratory of Reproductive Genetics, Ministry of Education, Zhejiang University, and Key Laboratory of Reproductive Health of Zhejiang Province, Hangzhou, China.
authors.forename: Mengkai
authors.initials: M
authors.lastname: Du
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Liang
authors.forename: Minyue
authors.initials: M
authors.lastname: Dong
authors.forename: Danqing
authors.initials: D
authors.lastname: Chen