title: Conjunctival mucoepithelial hyperplasia of the elderly.
abstract: The ocular surface is exposed to many chronic inflammatory stimuli, and goblet cell hyperplasia of the conjunctiva occurs in many situations. We report two cases of epithelial goblet cell hyperplasia with nonspecific chronic inflammation which occurred on the internal canthus of elderly people. These cases shared the same clinicopathological features that mimicked neoplastic lesion macroscopically, but are composed of nonspecific inflammatory changes pathologically. Immunostaining of the tissue showed few IgG4+ plasma cells, and no neoplastic changes were observed. Both cases arose in elderly patients over the age of 80 years. Pathogenesis and clinical significance of the lesion is unclear, but it might be age related. Recognition of this diagnosis might help us avoid overdiagnosis of malignancy and to reach the correct diagnosis.
authors.affiliation: Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan, akikooha@yahoo.co.jp.
authors.forename: Akiko
authors.initials: A
authors.lastname: Ohashi
authors.forename: Ahmed Ali
authors.initials: AA
authors.lastname: Elsayed
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Yasuma
authors.forename: Takahiko
authors.initials: T
authors.lastname: Iijima
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000369:Aged, 80 and over; D003229:Conjunctival Diseases / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D020397:Goblet Cells / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007074:Immunoglobulin G / Q000032:analysis; D010950:Plasma Cells / Q000276:immunology
chemical_list: D007074:Immunoglobulin G