title: Radioactive seed implantation and lobaplatin chemotherapy are safe and effective in treating patients with advanced lung cancer.
abstract: Objecive: To investigate the clinical safety and efficacy of CT-guided 125iodine (125I) seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol in treating patients with advanced lung cancer.
  
  
  METHODS
  Patients with advanced lung cancer and treated with spiral CT-guided 125I seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol were recruited.
  
  
  RESULTS
  Of the 36 patients, there were 40 nidi in total. The contrast-enhanced CT evaluation was conducted 60 d after treatment. Response evaluation suggested that 4 patients achieved complete remission (CR), 24 partial remission (PR), 4 stable disease (SD) and 4 progression disease (PD), with a total response rate of 77.8% (28/36).
  
  
  CONCLUSIONS
  CT-guided 125I seed implantation combined with percutaneous intra-tumor injection of chemotherapy emulsion of lobaplatin and lipiodol are safe and effective in treating patients with advanced lung cancer.
authors.affiliation: Invasive Technology Department, The First Hospital of Jilin University, Changchun, China E-mail : liulin54133@126.com.
authors.forename: Jia-Rui
authors.initials: JR
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy; D059248:Chemoradiotherapy; D003503:Cyclobutanes / Q000627:therapeutic use*; D004998:Ethiodized Oil / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009366:Neoplasm Seeding; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D011183:Postoperative Complications; D011379:Prognosis; D061089:Radiotherapy, Image-Guided; D012074:Remission Induction; D055752:Small Cell Lung Carcinoma / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D003503:Cyclobutanes; D007457:Iodine Radioisotopes; D009944:Organoplatinum Compounds; D004998:Ethiodized Oil; C066228:lobaplatin