title: Occurrence of bilaterally independent epileptic spasms after a corpus callosotomy in West syndrome.
abstract: We report a patient with intractable West syndrome whose epileptic spasms (ESs) were initially bilaterally synchronous, as is typical; after a complete corpus callosotomy, however, bilaterally independent ESs originated in either hemisphere. Activity of probable cortical origin associated with ESs was detected by observing ictal gamma oscillations. Brain MRI revealed no structural abnormality before surgery. This case suggests that ESs with a hemispheric origin may appear generalized because of synchronizing effects in the corpus callosum in some patients.
authors.affiliation: Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Shikatacho 2-chome 5-1, Kita-ku, Okayama, Japan. Electronic address: k_koba@md.okayama-u.ac.jp.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Kobayashi
authors.affiliation: Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Shikatacho 2-chome 5-1, Kita-ku, Okayama, Japan.
authors.forename: Fumika
authors.initials: F
authors.lastname: Endoh
authors.affiliation: Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Shikatacho 2-chome 5-1, Kita-ku, Okayama, Japan; Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Toda
authors.affiliation: Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Shikatacho 2-chome 5-1, Kita-ku, Okayama, Japan.
authors.forename: Makio
authors.initials: M
authors.lastname: Oka
authors.affiliation: Epilepsy Center, Nagasaki Medical Center, Kubara 2-1001-1, Omura, Nagasaki, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Baba
authors.affiliation: Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Shikatacho 2-chome 5-1, Kita-ku, Okayama, Japan; Asahigawaso Rehabilitation and Medical Center, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ohtsuka
authors.affiliation: Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Shikatacho 2-chome 5-1, Kita-ku, Okayama, Japan.
authors.forename: Harumi
authors.initials: H
authors.lastname: Yoshinaga
mesh_terms: D003337:Corpus Callosum / Q000601:surgery*; D000069279:Drug Resistant Epilepsy / Q000503:physiopathology* / Q000601:surgery*; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007223:Infant; D019635:Neurosurgical Procedures / Q000009:adverse effects; D011183:Postoperative Complications / Q000503:physiopathology*; D013036:Spasms, Infantile / Q000503:physiopathology* / Q000601:surgery*; D016896:Treatment Outcome
keywords: Bilateral independence; Callosotomy; Epileptic spasms; West syndrome