title: Shift work and its association with metabolic disorders.
abstract: Although the health burden of shift work has not been extensively studied, evidence suggests that it may affect the metabolic balance and cause obesity and other metabolic disorders. Sleep deprivation, circadian desynchronization and behavioral changes in diet and physical activity are among the most commonly mentioned factors in studies of the association between night work and metabolic disorders. Individual adaptation to night work depends greatly on personal factors such as family and social life, but occupational interventions may also make a positive contribution to the transition to shift work, such as exposure to bright lights during the night shift, melatonin use, shift regularity and clockwise rotation, and dietary adaptations for the metabolic needs of night workers. The evaluation of the impact of night work on health and of the mechanisms underlying this relationship can serve as a basis for intervention strategies to minimize the health burden of shift work. This review aimed to identify highlights regarding therapeutic implications following the association between night and shift work and metabolic disorders, as well as the mechanisms and pathways responsible for these relationships.
authors.affiliation: Division of Occupational Medicine, Hospital de Clínicas de Porto, Alegre, Rio Grande do Sul Brazil ; Post-graduate program in Medical Sciences, Endocrinology, Universidade Federal do, Porto Alegre, Rio Grande do Sul Brazil.
authors.forename: Maria Carlota Borba
authors.initials: MC
authors.lastname: Brum
authors.affiliation: Division of Occupational Medicine, Hospital de Clínicas de Porto, Alegre, Rio Grande do Sul Brazil ; Post-graduate program in Medical Sciences, Endocrinology, Universidade Federal do, Porto Alegre, Rio Grande do Sul Brazil.
authors.forename: Fábio Fernandes Dantas
authors.initials: FF
authors.lastname: Filho
authors.affiliation: Department of Internal Medicine, Medical School, Universidade Federal do, Porto Alegre, Rio Grande do Sul Brazil.
authors.forename: Claudia Carolina
authors.initials: CC
authors.lastname: Schnorr
authors.affiliation: Department of Internal Medicine, Medical School, Universidade Federal do, Porto Alegre, Rio Grande do Sul Brazil.
authors.forename: Gustavo Borchardt
authors.initials: GB
authors.lastname: Bottega
authors.affiliation: Post-graduate program in Medical Sciences, Endocrinology, Universidade Federal do, Porto Alegre, Rio Grande do Sul Brazil ; Department of Internal Medicine, Medical School, Universidade Federal do, Porto Alegre, Rio Grande do Sul Brazil ; Division of Endocrinology, Hospital de Clínicas de Porto Alegre, Rua Ramiro, Barcelos 2350, Prédio 12, 4° andar, Porto Alegre, Rio Grande do Sul 90035-003 Brazil.
authors.forename: Ticiana C
authors.initials: TC
authors.lastname: Rodrigues
keywords: Diabetes; Hypertension; Insulin resistance; Metabolic syndrome; Obesity; Shift work; Sleep restriction