title: Epidemiological characteristics of bloodstream infections in patients with different degrees of liver disease.
abstract: Observational retrospective study to evaluate the etiology, the outcome and the risk factors of bloodstream infections (BSIs) in patients with liver disease. One hundred and forty-eight BSIs were diagnosed (infection rate: 0.60 per 100 days of hospital stay), 62 BSIs (41.9 %) were associated with Gram-positive bacteria (infection rate: 0.25 per 100 days of hospital stay) and 80 (54.4 %) with Gram-negative bacteria (infection rate: 0.32 per 100 days of hospital stay). Admission-associated mortality was higher in patients with BSI than in those without BSI (20.6 versus 5.0 %, p < 0.001). Patients with cirrhosis had an increased risk to develop a BSI compared with patients with chronic hepatitis, specifically for Gram-positive (and Staphylococcus spp)-related BSI.
authors.affiliation: SC Virologia e Microbiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Micaela
authors.initials: M
authors.lastname: Brandolini
authors.affiliation: SC Virologia e Microbiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.|Biometric Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Corbella
authors.affiliation: Biometric Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: De Silvestri
authors.affiliation: SC Virologia e Microbiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Tinelli
authors.affiliation: Laboratorio Analisi Chimico-Cliniche, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Albonico
authors.affiliation: Laboratorio Analisi Chimico-Cliniche, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Albertini
authors.affiliation: Clinica Malattie Infettive, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Ludovisi
authors.affiliation: Divisione Malattie Infettive e Tropicali, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Bruno
authors.affiliation: SC Virologia e Microbiologia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Marone
authors.affiliation: Clinica Malattie Infettive, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Minoli
authors.affiliation: Clinica Malattie Infettive, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. e.seminari@smatteo.pv.it.
authors.forename: Elena
authors.initials: E
authors.lastname: Seminari
mesh_terms: D000368:Aged; D005260:Female; D006090:Gram-Negative Bacteria / Q000145:classification / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000145:classification / Q000302:isolation & purification; D006801:Humans; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D016019:Survival Analysis; D016896:Treatment Outcome
keywords: Bloodstream infection; Chronic hepatitis; Liver cirrhosis