title: A 19-year-old at 37 weeks gestation with an acute acetylsalicylic acid overdose.
abstract: Acute salicylate overdose in pregnancy is potentially fatal for both the mother and fetus and presents a unique challenge in intensive care management. While suggested thresholds exist for hemodialysis in adults with toxic salicylate ingestion, it is unclear if these thresholds remain appropriate for the gravid patient, particularly given that medications such as acetylsalicylic acid may cross the placental barrier and accumulate in the fetal bloodstream. We describe a case of a gravid patient at ∼37 weeks gestational age with a self-reported acetylsalicylic acid ingestion of 32.5 g and review prior cases of both acute and chronic salicylate ingestion in pregnancy in order to determine the clinical precedent for hemodialysis in this situation.
authors.affiliation: Harvard Medical School, Boston, MA, USA.
authors.forename: Huma
authors.initials: H
authors.lastname: Farid
authors.affiliation: Harvard Medical School, Boston, MA, USA.
authors.forename: Monica H
authors.initials: MH
authors.lastname: Wojcik
authors.affiliation: Harvard Medical School, Boston, MA, USA ; Renal Division, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Christopher
keywords: acetylsalicylic acid; hemodialysis; overdose; pregnancy; salicylate toxicity