title: Serotonin and impulsive aggression.
abstract: Aggression is a behavior with evolutionary origins, but is often both destructive and maladaptive in today's society. Research over the past several decades has confirmed the involvement of neurotransmitter function in aggressive behavior. This research has centered around the "serotonin hypothesis." As this literature continues to grow, guided by pre-clinical research and aided by the application of increasingly sophisticated neuroimaging methodology, a more complex picture has emerged. As current pharmacological and therapeutic interventions are effective but imperfect, it is hoped that new insights into the neurobiology of aggression will reveal novel avenues for treatment of this destructive and costly behavior.
authors.affiliation: 1Clinical Neuroscience & Psychopharmacology Research Unit,Department of Psychiatry (MC#3077),Pritzker School of Medicine,University of Chicago,Chicago,Illinois,USA.
authors.forename: Emil F
authors.initials: EF
authors.lastname: Coccaro
authors.affiliation: 1Clinical Neuroscience & Psychopharmacology Research Unit,Department of Psychiatry (MC#3077),Pritzker School of Medicine,University of Chicago,Chicago,Illinois,USA.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Fanning
authors.affiliation: 2Department of Psychiatry,University of Illinois College of Medicine,Chicago,Illinois,USA.
authors.forename: K Luan
authors.initials: KL
authors.lastname: Phan
authors.affiliation: 1Clinical Neuroscience & Psychopharmacology Research Unit,Department of Psychiatry (MC#3077),Pritzker School of Medicine,University of Chicago,Chicago,Illinois,USA.
authors.forename: Royce
authors.initials: R
authors.lastname: Lee
mesh_terms: D000374:Aggression / Q000502:physiology*; D006801:Humans; D007175:Impulsive Behavior / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D018490:Serotonin Agents / Q000627:therapeutic use; D059020:Suicidal Ideation
chemical_list: D018490:Serotonin Agents; D012701:Serotonin
keywords: Aggression; neuroimaging; neurotransmitters; receptors; serotonin