title: TNF-a (-238G/A and -308G/A) gene polymorphisms may not contribute to the risk of ischemic stroke.
abstract: BACKGROUND
  The common and major pathological change in ischemic stroke is atherosclerosis in the artery. Tumor necrosis factor-a (TNF-a) is closely related to the pathogenesis of atherosclerosis. The aim of our study was to investigate whether TNF-a gene variants (-238G/A and -308G/A) are associated with ischemic stroke.
  
  
  METHODS
  A total of 619 ischemic stroke patients and 612 controls were recruited to estimate the frequencies of two TNF-a (-238G/A and -308G/A) single nucleotide polymorphisms using a Sequenom MassARRAY time-of-flight mass spectrometer. The association between TNF-a gene polymorphisms and ischemic stroke risk was evaluated by computing the odds ratio (OR) and 95% Confidence Interval with multivariate unconditional logistic regression analyses.
  
  
  RESULTS
  The OR results indicated that no significant associations were found between TNF-a gene (-238G/A and -308G/A) polymorphisms and the risk of ischemic stroke using five genetic models, including the allele model (A vs. G), co-dominant model 1 (GA vs. GG), co-dominant model 2 (AA vs. GG), the dominant model (AA+GA vs. GG), and the recessive model (GG+GA vs. AA).
  
  
  CONCLUSIONS
  The TNF-a (-238G/A and -308G/A) gene polymorphisms may not be a susceptible predictor of ischemic stroke in Chinese populations.
authors.affiliation: a First Affiliated Hospital , Guangxi University of Chinese Medicine , Nanning , Guangxi , China.
authors.forename: Lian
authors.initials: L
authors.lastname: Gu
authors.affiliation: a First Affiliated Hospital , Guangxi University of Chinese Medicine , Nanning , Guangxi , China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Wu
authors.affiliation: b School of Public Health of Guangxi Medical University , Nanning , Guangxi , China.
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.affiliation: a First Affiliated Hospital , Guangxi University of Chinese Medicine , Nanning , Guangxi , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.affiliation: a First Affiliated Hospital , Guangxi University of Chinese Medicine , Nanning , Guangxi , China.
authors.forename: Baoyun
authors.initials: B
authors.lastname: Liang
authors.affiliation: a First Affiliated Hospital , Guangxi University of Chinese Medicine , Nanning , Guangxi , China.
authors.forename: Jinjing
authors.initials: J
authors.lastname: Tan
authors.affiliation: a First Affiliated Hospital , Guangxi University of Chinese Medicine , Nanning , Guangxi , China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Cai
authors.affiliation: a First Affiliated Hospital , Guangxi University of Chinese Medicine , Nanning , Guangxi , China.
authors.forename: Haiyun
authors.initials: H
authors.lastname: Jiang
authors.affiliation: a First Affiliated Hospital , Guangxi University of Chinese Medicine , Nanning , Guangxi , China.
authors.forename: Qiugui
authors.initials: Q
authors.lastname: Wei
authors.affiliation: a First Affiliated Hospital , Guangxi University of Chinese Medicine , Nanning , Guangxi , China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Shen
authors.affiliation: a First Affiliated Hospital , Guangxi University of Chinese Medicine , Nanning , Guangxi , China.
authors.forename: Ailing
authors.initials: A
authors.lastname: Wei
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: 238G/A polymorphism; 308G/A polymorphism; TNF-a; ischemic stroke