title: MicroRNAs and lncRNAs in senescence: A re-view.
abstract: Cellular senescence is a stress response to a variety of extrinsic and intrinsic insults that cause genomic or epigenomic perturbations. It is now widely recognized as a potent tumor suppressor mechanism as well as a biological process impacting aging and organismal development. Like other cell fate decisions, senescence is executed and maintained by an intricate network of transcription factors (TFs), chromatin modifiers, and noncoding RNAs (ncRNAs). Altogether, these factors cooperate to implement the gene expression program that initiates and sustains the senescent phenotype. In the context of senescence, microRNAs (miRs) and long ncRNAs have been found to play regulatory roles at both the transcriptional and post-transcriptional levels. In this review, we discuss recent developments in the field and point toward future research directions to gain a better understanding of ncRNAs in senescence.
authors.affiliation: Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, Department of Cell Biology and Infection, Paris, France.|INSERM, U993, Paris, France.
authors.forename: Oliver
authors.initials: O
authors.lastname: Bischof
authors.affiliation: Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, Department of Cell Biology and Infection, Paris, France.|INSERM, U993, Paris, France.
authors.forename: Ricardo Iván
authors.initials: RI
authors.lastname: Martínez-Zamudio
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D034622:RNA Interference; D062085:RNA, Long Noncoding / Q000502:physiology*
chemical_list: D035683:MicroRNAs; D062085:RNA, Long Noncoding
keywords: RNA interference; aging; chromatin; noncoding RNA; senescence; transcription factors; transcriptional regulation