title: The evolution of IL-4 and IL-13 and their receptor subunits.
abstract: This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the role of these molecules and signalling pathways in non-mammalian vertebrates.
authors.affiliation: Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, UK.
authors.forename: Tiehui
authors.initials: T
authors.lastname: Wang
authors.affiliation: Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, UK. Electronic address: c.secombes@abdn.ac.uk.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Secombes
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016207:Cytokines / Q000502:physiology; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics / Q000502:physiology*; D015847:Interleukin-4 / Q000235:genetics / Q000502:physiology*; D008024:Ligands; D008969:Molecular Sequence Data; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D018121:Receptors, Cytokine / Q000235:genetics / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D014714:Vertebrates
chemical_list: D016207:Cytokines; C578095:IL13 protein, human; C508598:IL4 protein, human; D018793:Interleukin-13; D008024:Ligands; D018121:Receptors, Cytokine; D015847:Interleukin-4
keywords: IL-4/13 molecules; IL-4/IL-13 evolution; IL-4R/IL-13R receptor evolution