title: Nanoparticle Formulation of AEA and BAEA Cellulose Carbamates Increases Biocompatibility and Antimicrobial Activity.
abstract: Antimicrobially active polymers with a cationic moiety gain increasing interest in health care providing a biocompatible alternative to commonly used products. They adhere to the polyanionic bacterial surface, disrupt cell membranes and kill bacteria. An efficient path to obtain amino group-containing cellulose is nucleophilic displacement reaction of p-toluenesulfonic acid ester and amines leading to 6-deoxy-6-(ω-aminoalkyl) aminocellulose carbamates. Spherical nanoparticles of the obtained 6-deoxy-6-(2-aminoethyl) amino (AEA) and 6-deoxy-6-{2-bis[N',N'-(2-aminoethyl)]aminoethyl}amino (BAEA) cellulose carbamate with a size range of 80-120 nm were produced. The AEA and BAEA cellulose carbamates exhibited significant antimicrobial activity with moderate cell compatibility. Nanoparticle formulation enhanced biocompatibility.
authors.affiliation: Department of Dermatology, University Hospital Jena, Erfurter Str. 35, D-07743, Jena, Germany. c.wiegand@med.uni-jena.de.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Wiegand
authors.affiliation: Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich-Schiller-University Jena, Humboldtstr. 10, D-07743, Jena, Germany.
authors.forename: Melanie
authors.initials: M
authors.lastname: Nikolajski
authors.affiliation: Department of Dermatology, University Hospital Jena, Erfurter Str. 35, D-07743, Jena, Germany.
authors.forename: Uta-Christina
authors.initials: UC
authors.lastname: Hipler
authors.affiliation: Center of Excellence for Polysaccharide Research, Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich-Schiller-University Jena, Humboldtstr. 10, D-07743, Jena, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Heinze
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials; D002482:Cellulose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005029:Ethylenediamines / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011073:Polyamines / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: C000608857:6-deoxy-6-(2-aminoethyl)amino cellulose carbamate; C000608858:6-deoxy-6-(2-bis(N',N'-(2-aminoethyl))aminoethyl)amino cellulose carbamate; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D005029:Ethylenediamines; D011073:Polyamines; D002482:Cellulose
keywords: aminocellulose carbamate; bacteria; biocompatibility; nanoparticle; wound infection