title: A systematic review and meta-analysis of beta-glucan consumption on glycemic control in hypercholesterolemic individuals.
abstract: Evidence from animal and observational studies has supported the beneficial effects of beta-glucan intake on glycemic control, but intervention studies in hypercholesterolemic crowd have generated mixed results and have not been systematically examined. In the present study, we aimed to quantitatively evaluate the relation between beta-glucan consumption from oats or barley on glycemic control in hypercholesterolemic individuals. A systematic literature review was conducted for relevant published randomized controlled trials studies (RCTs) in electronic databases through July 2014. Twelve trials with a total of 603 subjects were included in the meta-analysis. Beta-glucan consumption did not significantly affect measures of glycemic control. Summary estimates of weighted mean differences (WMD) and 95% confidence interval was 0.05 mmol/L (-0.11, 0.02) for fasting glucose concentration and 0.75 pmol/L (-1.82, 3.32) for fasting insulin concentrations. In conclusion, there was not a significant overall effect of beta-glucan intake on improvements of fasting glucose and insulin concentrations in hypercholesterolemic subjects.
authors.affiliation: Department of Traditional Chinese Medicine, The Second Clinical Medical College, Guangdong Medical College , Dongguan, Guangdong , China .
authors.forename: Ying
authors.initials: Y
authors.lastname: Zou
authors.forename: Dan
authors.initials: D
authors.lastname: Liao
authors.forename: Haohai
authors.initials: H
authors.lastname: Huang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Honggang
authors.initials: H
authors.lastname: Chi
mesh_terms: D018554:Avena; D001786:Blood Glucose; D004032:Diet / Q000379:methods*; D001467:Hordeum; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016032:Randomized Controlled Trials as Topic; D047071:beta-Glucans / Q000008:administration & dosage* / Q000097:blood* / Q000494:pharmacology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D047071:beta-Glucans
keywords: Beta-glucan; glycemic; hypercholesterolemic; meta-analysis