title: The long-term effects of radioactive phosphorous synoviorthesis on hemophilic arthropathy.
abstract: BACKGROUND
  Radioactive synoviorthesis was carried out by an injection of radioactive materials into the joint that has been known as a successful alternative treatment to invasive surgical synovectomy. This study was designed to evaluate short-term and long-term results and complications of radioactive synovectomy of hemophilic arthropathy using radioactive phosphorus.
  
  
  METHODS
  This study was conducted on 40 patients with hemophilic arthropathy. After obtaining clotting factors, the intra-articular injections of radioactive phosphorus were done. Thirteen patients were evaluated during 36 months (short-term follow-up) and 27 patients were followed up for more than 36 months (long-term follow-up). Patients were evaluated for hemarthrosis, factor consumption per month, joint range of motion (ROM) and clinical and radiological involvement grade.
  
  
  RESULTS
  The patients mean age was 22.9 ± 6.6 and there were 38 men and 2 women. Consumption of clotting factors was significantly reduced in the short-term follow-up of patients (p < 0.05), but there was no significant difference in the long-term follow-up (p > 0.05). ROM decreased significantly in the long-term follow-up (p < 0.05). Radiologic evaluation showed significantly increased involvement in their joints (p < 0.05).
  
  
  CONCLUSIONS
  Using radioactive synoviorthesis led in decreased consumption of clotting factors and the hemarthrosis incidence in short term but it did not have significant impact on clinical situation (ROM) and radiological findings of hemophilic patients in long-term follow-up.
authors.affiliation: Department of Orthopedics, Rasoul Akram Hospital, Iran University of Medical sciences, Tehran, Iran.
authors.forename: Amir Sobhani
authors.initials: AS
authors.lastname: Eraghi
authors.affiliation: Department of Orthopedics, Imam Khomeini Hospital, Tehran University of Medical sciences, Tehran, Iran.
authors.forename: Mohammad Hasan
authors.initials: MH
authors.lastname: Kaseb
authors.affiliation: Department of Orthopedics, Imam Khomeini Hospital, Tehran University of Medical sciences, Tehran, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Espandar
authors.affiliation: Radiologist, Imam Khomeini Hospital, Tehran University of Medical sciences, Tehran, Iran. Electronic address: shirinmardookhpour@yahoo.com.
authors.forename: Shirin
authors.initials: S
authors.lastname: Mardookhpour
mesh_terms: D055011:Ablation Techniques; D000293:Adolescent; D000328:Adult; D001779:Blood Coagulation Factors / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006395:Hemarthrosis / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006467:Hemophilia A / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007270:Injections, Intra-Articular; D007596:Joints / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects; D008297:Male; D010761:Phosphorus Radioisotopes / Q000627:therapeutic use*; D016059:Range of Motion, Articular / Q000528:radiation effects; D013583:Synovial Membrane / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects; D013997:Time Factors
chemical_list: D001779:Blood Coagulation Factors; D010761:Phosphorus Radioisotopes
keywords: Hemophilia; Radioactive synoviorthesis; Synovectomy