title: Even in the era of congenital hypothyroidism screening mild and subclinical sensorineural hearing loss remains a relatively common complication of severe congenital hypothyroidism.
abstract: Only few studies have focused on neurosensory hearing function of patients with congenital hypothyroidism (CH) identified by CH screening programs and treated early and, therefore, this issue remains still controversial. The aim of this study was to ascertain whether an early and adequate replacement treatment may be able to prevent sensorineural hearing loss in 32 screened children with CH and no associated risk factors for neuro-otologic alterations. These patients were recruited according to highly selective criteria aiming to preliminarily exclude the negative interference of both treatment variables and other underlying risk factors. All the selected patients underwent, at a median age of 15.4 years, an audiologic investigation, which evidenced a mild and subclinical hearing loss in 25% of them. The poorest hearing scores were recorded in the individuals with athyreosis and in those with absence of distal femur bony nucleus at CH diagnosis. The prevalence of hearing impairment was significantly higher in CH patients than in 32 age-matched control subjects with no CH (χ(2) = 6.3, p < 0.025). In light of these findings, we concluded that: a) 25% of CH patients detected by CH screening may show, at a median age of 15.4 years, a mild and subclinical hearing impairment, despite early and adequate replacement treatment; b) the risk of hearing loss is higher in CH young patients than in age-matched control subjects without CH; c) the risk of hearing loss is closely associated with the severity of CH; d) this risk is particularly relevant in the children with pre-natal onset of hypothyroidism.
authors.affiliation: Department of Otorhinolaryngology, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: rocco.bruno@unime.it.
authors.forename: Rocco
authors.initials: R
authors.lastname: Bruno
authors.affiliation: Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: tommaso.aversa@unime.it.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Aversa
authors.affiliation: Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: mariaausiliacatena@hotmail.com.
authors.forename: Mariaausilia
authors.initials: M
authors.lastname: Catena
authors.affiliation: Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: mariella.valenzise@unime.it.
authors.forename: Mariella
authors.initials: M
authors.lastname: Valenzise
authors.affiliation: Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: fortunato.lombardo@unime.it.
authors.forename: Fortunato
authors.initials: F
authors.lastname: Lombardo
authors.affiliation: Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: filippo.deluca@unime.it.
authors.forename: Filippo
authors.initials: F
authors.lastname: De Luca
authors.affiliation: Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: malgorzata.wasniewska@unime.it.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Wasniewska
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001301:Audiometry, Pure-Tone; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D003409:Congenital Hypothyroidism / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D061345:Early Medical Intervention; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult