title: Closing the Mad2 cycle.
abstract: Chromosome separation is regulated by a cycle that involves a protein undergoing an unusual topological conversion.
authors.affiliation: Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany and the Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Musacchio
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D006801:Humans; D064246:Mad2 Proteins / Q000378:metabolism*; D008941:Spindle Apparatus / Q000201:enzymology*
chemical_list: D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D064246:Mad2 Proteins; D000251:Adenosine Triphosphatases
keywords: AAA+ ATPase; C. elegans; HORMA domain protein; Mad2; biochemistry; biophysics; checkpoint proteins; mouse; spindle assembly checkpoint; structural biology