title: Reversible pH-controlled switching of an artificial antioxidant selenoenzyme based on pseudorotaxane formation and dissociation.
abstract: A pH-responsive artificial selenoenzyme was constructed by reversible binding between organoselenium compound a1 nd CB[6] to form a pseudorotaxane-based molecular switch in response to pH stimuli. The glutathione peroxidase (GPx) activity of the artificial selenoenzyme can be switched on/off in a mild and body suitable environment between pH = 7 and pH = 6.
authors.affiliation: Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012, People's Republic of China. junqiuliu@jlu.edu.cn.
authors.forename: Jiaxi
authors.initials: J
authors.lastname: Li
authors.forename: Chengye
authors.initials: C
authors.lastname: Si
authors.forename: Hongcheng
authors.initials: H
authors.lastname: Sun
authors.forename: Junyan
authors.initials: J
authors.lastname: Zhu
authors.forename: Tiezheng
authors.initials: T
authors.lastname: Pan
authors.forename: Shengda
authors.initials: S
authors.lastname: Liu
authors.forename: Zeyuan
authors.initials: Z
authors.lastname: Dong
authors.forename: Jiayun
authors.initials: J
authors.lastname: Xu
authors.forename: Quan
authors.initials: Q
authors.lastname: Luo
authors.forename: Junqiu
authors.initials: J
authors.lastname: Liu
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000737:chemistry; D005979:Glutathione Peroxidase / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D016566:Organoselenium Compounds / Q000737:chemistry*; D043862:Rotaxanes / Q000737:chemistry*; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D005979:Glutathione Peroxidase; D007093:Imidazoles; D016566:Organoselenium Compounds; D043862:Rotaxanes; C454805:cucurbit(6)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils