title: A novel clinical trial recruitment strategy for women's cancer.
abstract: OBJECTIVE
  To address a deficiency in clinical trial and research enrollment in gynecologic cancer studies, we launched a paper based patient research registry. To improve registry enrollment, we transitioned to an online registry and trial matching mechanism to aid women in accessing open studies.
  
  
  METHODS
  Utilizing a validated verification platform, we designed a web-based registry and trial matching mechanism for women over age 18. Participants completed a questionnaire to provide information for trial matching. A focus group of registry participants was held 9 months after the start of the study to evaluate barriers to participation.
  
  
  RESULTS
  A total of 322 women were enrolled in the online registry over a 14 month period which was a 4.3 fold increase over the paper-based registry (p<0.0001). Two hundred and sixty three (82%) women were matched to at least one study. Fifteen percent (39/263) of those eligible for studies went on to enroll. The online enrollment rate to studies was not different from that observed in the paper-based registry (26/172, p=0.934), however, the web-based registry linked participants to subsequent studies 27% more rapidly (68 (+/-98) days vs. 93 (+/-81) days for the paper-based registry, p=0.017). Focus group participants identified areas for improvement.
  
  
  CONCLUSIONS
  Web-based patient driven registry provides dramatic improvement in the number of participants enrolled and the time to trial linkage compared to a paper based registry at a single institution. Further studies of barriers to research participation are necessary to improve on this model.
authors.affiliation: Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States. Electronic address: Bobbie.rimel@cshs.org.
authors.forename: B J
authors.initials: BJ
authors.lastname: Rimel
authors.affiliation: Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States.
authors.forename: Jenny
authors.initials: J
authors.lastname: Lester
authors.affiliation: Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States.
authors.forename: Leah
authors.initials: L
authors.lastname: Sabacan
authors.affiliation: Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States.
authors.forename: Diane
authors.initials: D
authors.lastname: Park
authors.affiliation: Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States.
authors.forename: Catherine
authors.initials: C
authors.lastname: Bresee
authors.affiliation: Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States.
authors.forename: Catherine
authors.initials: C
authors.lastname: Dang
authors.affiliation: Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States.
authors.forename: Beth
authors.initials: B
authors.lastname: Karlan
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D005260:Female; D005833:Genital Neoplasms, Female / Q000628:therapy*; D006801:Humans; D020407:Internet; D008875:Middle Aged; D018579:Patient Selection; D012042:Registries; D016387:Women's Health
keywords: Clinical trial; Enrollment; Registry