title: Therapeutic effects of hybrid liposomes with downregulation of inflammatory cytokine for model mice of rheumatoid arthritis in vivo.
abstract: Therapeutic effects of HL for a collagen-induced arthritis (CIA) mouse models of HL-23 composed of 95mol% l-α-dimyristoylphosphatidylcholine (DMPC) and 5mol% polyoxyethylenedodecylether (C12(EO)23) in vivo were examined. Remarkably high therapeutic effects of HL-23 for CIA mouse models were obtained on the basis of clinical assessment of arthritis. The reduction of hyperplastic synovial membrane (pannus tissue) and destruction of the cartilage and bone by HL-23 was revealed on the basis of hematoxylin and eosin (HE) and safranin O staining. Furthermore, the downregulation of inflammatory cytokines such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6 for CIA mouse models treated with HL-23 were investigated. Remarkably high therapeutic effects without joint swelling were obtained in CIA mouse models treated with HL-23.
authors.affiliation: Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1, Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ichihara
authors.affiliation: Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1, Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamasaki
authors.affiliation: Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1, Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
authors.forename: Motoki
authors.initials: M
authors.lastname: Hino
authors.affiliation: Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1, Ikeda, Nishi-ku, Kumamoto 860-0082, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Ueoka
authors.affiliation: Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1, Ikeda, Nishi-ku, Kumamoto 860-0082, Japan. Electronic address: matumoto@life.sojo-u.ac.jp.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D016207:Cytokines / Q000378:metabolism*; D004134:Dimyristoylphosphatidylcholine / Q000627:therapeutic use; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry* / Q000627:therapeutic use*; D051379:Mice; D008811:Mice, Inbred DBA; D011092:Polyethylene Glycols / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D053583:Interleukin-1beta; D015850:Interleukin-6; D008081:Liposomes; D014409:Tumor Necrosis Factor-alpha; C552190:polyoxyethylene (23) dodecylether; D011092:Polyethylene Glycols; D004134:Dimyristoylphosphatidylcholine
keywords: Chemotherapy; Collagen-induced arthritis mouse models; Hybrid liposomes; In vivo; Rheumatoid arthritis