title: Pain perception in acute model mice of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
abstract: BACKGROUND
  Pain is the most prominent non-motor symptom observed in patients with Parkinson's disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied. We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD to analyze the relationship between pain sensory abnormalities and the degeneration of dopaminergic neurons.
  
  
  RESULTS
  The latency to fall off the rotarod and the total distance traveled in round chamber were significantly reduced in MPTP-induced PD mice, consistent with motor dysfunction. MPTP-treated mice also showed remarkably shorter nociceptive response latencies compared to saline-treated mice and the subcutaneous injection of L-3,4-dihydroxyphenylalanine (L-DOPA) partially reversed pain hypersensitivity induced by MPTP treatment. We found that degeneration of cell bodies and fibers in the substantia nigra pars compacta and the striatum of MPTP-treated mice. In addition, astrocytic and microglial activation was seen in the subthalamic nucleus and neuronal activity was significantly increased in the striatum and globus pallidus. However, we did not observe any changes in neurons, astrocytes, and microglia of both the dorsal and ventral horns in the spinal cord after MPTP treatment.
  
  
  CONCLUSIONS
  These results suggest that the dopaminergic nigrostriatal pathway may have a role in inhibiting noxious stimuli, and that abnormal inflammatory responses and neural activity in basal ganglia is correlated to pain processing in PD induced by MPTP treatment.
authors.affiliation: Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747, South Korea. wizbella@snu.ac.kr.
authors.forename: Jihye
authors.initials: J
authors.lastname: Park
authors.affiliation: Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747, South Korea. cslim@snu.ac.kr.
authors.forename: Chae-Seok
authors.initials: CS
authors.lastname: Lim
authors.affiliation: Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. hseo@knu.ac.kr.
authors.forename: Hyunhyo
authors.initials: H
authors.lastname: Seo
authors.affiliation: Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. pca2477@naver.com.
authors.forename: Chung-Ah
authors.initials: CA
authors.lastname: Park
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Toronto, The center for the study of pain, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. minzhuo10@gmail.com.
authors.forename: Min
authors.initials: M
authors.lastname: Zhuo
authors.affiliation: Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747, South Korea. kaang@snu.ac.kr.
authors.forename: Bong-Kiun
authors.initials: BK
authors.lastname: Kaang
authors.affiliation: Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842, South Korea. irislkm@knu.ac.kr.
authors.forename: Kyungmin
authors.initials: K
authors.lastname: Lee
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D001253:Astrocytes / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000187:drug effects / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D058748:Pain Perception / Q000187:drug effects*; D010300:Parkinson Disease
chemical_list: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine