title: Improvement of spatial memory disorder and hippocampal damage by exposure to electromagnetic fields in an Alzheimer's disease rat model.
abstract: Although some epidemiological investigations showed a potential association between long-term exposure of extremely low frequency electromagnetic fields (ELF-EMF) and Alzheimer's disease (AD), no reasonable mechanism can explain this association, and the related animal experiments are rare. In this study, ELF-EMF exposure (50 Hz 400 µT 60 d) combined with D-galactose intraperitoneal (50 mg/kg, q.d., 42 d) and Aβ25-35 hippocampal (5 μl/unilateral, bilateral, single-dose) injection was implemented to establish a complex rat model. Then the effects of ELF-EMF exposure on AD development was studied by using the Morris water maze, pathological analysis, and comparative proteomics. The results showed that ELF-EMF exposure delayed the weight gain of rats, and partially improved cognitive and clinicopathologic symptoms of AD rats. The differential proteomic analysis results suggest that synaptic transmission, oxidative stress, protein degradation, energy metabolism, Tau aggregation, and inflammation involved in the effects mentioned above. Therefore, our findings indicate that certain conditions of ELF-EMF exposure could delay the development of AD in rats.
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zuo
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Dewen
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Ruiyun
authors.initials: R
authors.lastname: Peng
authors.affiliation: Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, 6 North Second Street, Zhongguancun, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Song
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Shuiming
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Xinping
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Yabing
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Shaoxia
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Lifeng
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Experimental Pathology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D000818:Animals; D004574:Electromagnetic Fields; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology* / Q000528:radiation effects; D008297:Male; D018782:Maze Learning; D008569:Memory Disorders / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar