title: Lipase-modified pH-responsive microgel-based optical device for triglyceride sensing.
abstract: Lipase-modified pH-responsive poly(N-isopropylacrylamide)-based microgels were synthesized. An optical device was subsequently fabricated by sandwiching the enzyme loaded responsive microgels between two thin Au layers, and their response to triolein, a model triglyceride, was investigated. The device's response depended on the triglyceride concentration, demonstrating its potential application as a triglyceride biosensor.
authors.affiliation: Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2 Canada. michael.serpe@ualberta.ca.
authors.forename: Qiang Matthew
authors.initials: QM
authors.lastname: Zhang
authors.forename: Darren
authors.initials: D
authors.lastname: Berg
authors.forename: Samuel M
authors.initials: SM
authors.lastname: Mugo
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Serpe
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D015374:Biosensing Techniques / Q000295:instrumentation*; D005782:Gels; D006046:Gold / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008049:Lipase / Q000737:chemistry* / Q000378:metabolism; D055096:Optical Devices; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties; D014280:Triglycerides / Q000032:analysis*
chemical_list: D000180:Acrylic Resins; D005782:Gels; D011108:Polymers; D014280:Triglycerides; C052970:poly-N-isopropylacrylamide; D006046:Gold; D008049:Lipase