title: HIV-1 antiviral behavior of anionic PPI metallo-dendrimers with EDA core.
abstract: The development of novel strategies to prevent HIV-1 infection is of outstanding relevance. Metal complexes of Cu(2+), Ni(2+), Co(2+) and Zn(2+) derived from sulfonated and carboxylated poly(propylene imine) dendrimers with ethylenediamine core were evaluated as tunable antiviral agents against HIV-1. After demonstrating their biocompatibility, specific trends in the antiviral properties were found, related to both the dendritic scaffold (peripheral group, generation) and the bound metal ions (sort, amount). In HEC-1A and VK-2 cell lines, as model of the first barrier against HIV-1 infection, a high preventive inhibitory action was found, which also avoided virus internalization inside cells and inhibited both CCR5 and CXCR4 HIV-1 strains. In peripheral blood mononuclear cells (PBMC), as model of the second barrier, a dual preventive and therapeutic behavior was observed. A rational design of such metallodendrimers opens new avenues for the production of versatile and efficient treatments against HIV-1 infection.
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain.
authors.forename: Sandra
authors.initials: S
authors.lastname: García-Gallego
authors.affiliation: Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain; Laboratorio de Inmunobiología Molecular, Plataforma de laboratorio, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Díaz
authors.affiliation: Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain; Laboratorio de Inmunobiología Molecular, Plataforma de laboratorio, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Jiménez
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Gómez
authors.affiliation: Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, Campus Universitario, E-28871 Alcalá de Henares, Spain; Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain. Electronic address: javier.delamata@uah.es.
authors.forename: F Javier
authors.initials: FJ
authors.lastname: de la Mata
authors.affiliation: Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Spain; Laboratorio de Inmunobiología Molecular, Plataforma de laboratorio, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address: mmunoz.hgugm@salud.madrid.org.
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Muñoz-Fernández
mesh_terms: D000838:Anions; D019380:Anti-HIV Agents / Q000494:pharmacology*; D050091:Dendrimers / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D008670:Metals / Q000737:chemistry*; D011126:Polypropylenes / Q000737:chemistry*
chemical_list: D000838:Anions; D019380:Anti-HIV Agents; D050091:Dendrimers; D008670:Metals; D011126:Polypropylenes; C443641:poly(propyleneimine)
keywords: Carboxylate; Dendrimer; HIV; Sulfonate; Transition metal