title: Transcatheter closure of ventricular septal defect in patients with aortic valve prolapse and mild aortic regurgitation: feasibility and preliminary outcome.
abstract: OBJECTIVE
  To evaluate the feasibility, safety and efficacy of transcatheter closure of ventricular septal defect (VSD) in patients with aortic valve prolapse (AVP) and mild aortic regurgitation (AR).
  
  
  METHODS
  Between January 2008 and July 2014, transcatheter closure of VSD was attempted in 65 patients.
  
  
  RESULTS
  The total intermediate closure successful rate in all subjects was 96.9%. During the perioperative period, no death, major bleeding, pericardial tamponade, occluder dislodgement, residual shunt or hemolysis occurred. Two procedures had been forced to suspend due to significant aggregation of device related aortic regurgitation, three cases of transient complete left bundle branch block occurred but did not sustain. At 1-year follow-up, no patients had residual shunts and complications. Furthermore, grade of residual AR were relieved in 61.9% (39/63) cases and degree of AVP were ameliorated in 36.5% (23/63) patients;
  
  
  CONCLUSIONS
  Transcatheter closure VSD in selected patients with AVP and mild AR is technically feasible and highly effective. Long term safety and efficacy needs to be assessed.
authors.affiliation: Zhujiang Hospital Affiliated to Southern Medical University, Guangzhou 510000, PR China; Department of Pediatric Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Science, Guangdong General Hospital, Guangzhou 510080, PR China; Department of Cardiology, Hainan General Hospital, Haikou 570203, PR China.
authors.forename: Guan-Liang
authors.initials: GL
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Hainan General Hospital, Haikou 570203, PR China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Li
authors.affiliation: Department of Cardiology, Hainan General Hospital, Haikou 570203, PR China.
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Li
authors.affiliation: Zhujiang Hospital Affiliated to Southern Medical University, Guangzhou 510000, PR China; Department of Pediatric Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Science, Guangdong General Hospital, Guangzhou 510080, PR China. Electronic address: drzhiweizhang@163.com.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhang
keywords: Aortic regurgitation; Aortic valve prolapsed; Transcatheter closure; Ventricular septal defect