title: Relation between plasmatic and cerebrospinal fluid oxidative stress biomarkers and intrathecal Ig synthesis in Multiple Sclerosis patients.
abstract: The aim of this study was to evaluate if cerebrospinal fluid (CSF) oxidative stress biomarkers were related to plasmatic levels and to intrathecal Ig synthesis in 51 patients with Multiple Sclerosis (MS) or clinically isolated syndrome (CIS). Plasmatic and CSF ferric reducing ability (FRA) showed a significant positive correlation (ρ 0.28, p=0.04), while advanced oxidation protein products (AOPPs) did not. A negative correlation was found between IgG synthesis index and CSF FRA levels. No difference in CSF AOPPs or FRA was observed between patients with and without intrathecal IgM synthesis. Our results indicate that plasmatic and CSF FRA are strictly linked, while CSF oxidative stress biomarkers are not related to intrathecal Ig synthesis.
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: lpasquali@med.unipi.it.
authors.forename: Livia
authors.initials: L
authors.lastname: Pasquali
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy; Azienda ULSS 12 "Veneziana", dell'Angelo Hospital, Neurology Unit, Via Paccagnella 11, 30174 Mestre (Venice), Italy. Electronic address: chiara.pecori@hotmail.com.
authors.forename: Chiara
authors.initials: C
authors.lastname: Pecori
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: lucia.chico@katamail.com.
authors.forename: Lucia
authors.initials: L
authors.lastname: Chico
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: a.iudice@neuro.med.unipi.it.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Iudice
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: g.siciliano@med.unipi.it.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Siciliano
authors.affiliation: Department of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Via Savi 10, 56126 Pisa, Italy. Electronic address: u.bonuccelli@neuro.med.unipi.it.
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Bonuccelli
mesh_terms: D000293:Adolescent; D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood* / Q000134:cerebrospinal fluid*; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002712:Chlorides / Q000378:metabolism; D005260:Female; D005290:Ferric Compounds / Q000378:metabolism; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000276:immunology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013346:Subarachnoid Space / Q000276:immunology; D055815:Young Adult
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers; D002712:Chlorides; D005290:Ferric Compounds; D007075:Immunoglobulin M; D007136:Immunoglobulins; C024555:ferric chloride
keywords: AOPP; Cerebrospinal fluid; FRA; Multiple Sclerosis