title: Butrylcholinesterase activity in chronic liver disease patients and correlation with Child-Pugh classification and MELD scoring system.
abstract: BACKGROUND
  After 40 years since establishment of Child-Pugh staging, 14 years since establishment of MELD scoring system, and 25 years since establishment of King's College Criteria, there is still a search for more accurate systems for determination of prognosis in patients with acute liver failure--cirrhosis and prioritization for receipt of a liver transplant--prediction of post transplant mortality. Butrylcholinesterase is an enzyme which is synthesized in the liver. The aim of the study was to evaluate the clinical utility of butrylcholinesterase as a discriminatory and prognostic factor in chronic liver disease patients.
  
  
  METHODS
  Intergroup diversity for butrylcholinesterase activity was investigated in sixty cirrhotic, 20 chronic hepatitis patients, and 20 healthy subjects. Correlations between butrylcholinesterase activity and Child-Pugh classification and MELD scoring systems were examined.
  
  
  RESULTS
  In addition to the statistically significant decrease in butrylcholinesterase activity among Child-Pugh A/B/C stages, the decrease in butrylcholinesterase activity was also statistically significant in control vs. Child-Pugh stage A and chronic hepatitis vs. Child Pugh stage A groups. A statistically significant correlation was determined between butrylcholinesterase activity and Child Pugh/MELD scores.
  
  
  CONCLUSIONS
  Serum butrylcholinesterase activity might be helpful for discrimination of chronic hepatitis from cirrhosis after determination of reliable cut-off levels and dependent on the reductions of serum levels in acute liver failure and cirrhosis. It might be a useful tool for prioritization of liver transplantation.
authors.forename: Halide Edip
authors.initials: HE
authors.lastname: Temel
authors.forename: Tuncer
authors.initials: T
authors.lastname: Temel
authors.forename: Dondu Uskudar
authors.initials: DU
authors.lastname: Cansu
authors.forename: Ayşegul
authors.initials: A
authors.lastname: Ozakyol
mesh_terms: D000328:Adult; D001706:Biopsy; D015992:Body Mass Index; D002091:Butyrylcholinesterase / Q000097:blood* / Q000378:metabolism*; D016022:Case-Control Studies; D058625:End Stage Liver Disease / Q000145:classification / Q000201:enzymology*; D005260:Female; D064368:Healthy Volunteers; D022781:Hepatocytes / Q000201:enzymology; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002091:Butyrylcholinesterase