title: Oral Cavity Clear Cell Odontogenic Carcinoma.
abstract: A case of clear cell odontogenic carcinoma of the oral cavity is described in this sine qua non radiology-pathology correlation article. CT demonstrated a solid and cystic mass arising from the mandible. Histology demonstrated variably-sized nests of clear to pale eosinophilic cells with occasional central necrosis embedded in a hyalinized to fibrocellular stroma. The specimen was also positive for the characteristic rearrangement of the EWSR1 (22q12) locus in 93.5% of interphase cells.
authors.affiliation: Department of Radiology, Pritzker School of Medicine, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA. dtg1@uchicago.edu.
authors.forename: Daniel Thomas
authors.initials: DT
authors.lastname: Ginat
authors.affiliation: Department of Medicine, Section of Hematology Oncology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: Victoria
authors.initials: V
authors.lastname: Villaflor
authors.affiliation: Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Cipriani
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009808:Odontogenic Tumors / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C560860:EWSR1-ATF1 fusion protein, human; D015514:Oncogene Proteins, Fusion
keywords: CT; Clear cell odontogenic carcinoma; Oral cavity; Pathology