title: Association Between Kidney Dysfunction and Carotid Atherosclerosis in Community-Based Older Adults in China.
abstract: We investigated the association between kidney dysfunction and carotid atherosclerosis in community-based older adults. This study consisted of 1257 participants, aged 55 years and older and free of cardiovascular disease. Kidney dysfunction was classified as mild, moderate, and severe (estimated glomerular filtration rate, 45-59, 30-44, and <30 mL/min/1.73 m(2), respectively). We found that the mean common carotid artery intima-media thickness (CCA-IMT) progressively increased with decrement in kidney function (P < .001). Even mild kidney dysfunction was significantly associated with CCA-IMT thickening (CCA-IMT ≥1.0 mm; odds ratio [OR] 1.52; 95% confidence interval [CI] 1.16-1.99) compared to normal kidney function. A significantly increased presence of heterogeneous plaque was observed in relation to decreased kidney function (P for trend = .011), that is, even a mild kidney dysfunction was a potential independent risk factor for heterogeneous plaque (OR 1.43; 95% CI 1.04-1.98). Mild kidney dysfunction may be a predictor of early or accelerated carotid atherosclerosis in older adults.
authors.affiliation: Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Gu
authors.affiliation: Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China xhfang163@163.com.
authors.forename: Xianghua
authors.initials: X
authors.lastname: Fang
authors.affiliation: Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Hua
authors.affiliation: Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Tang
authors.affiliation: Department of Neurological Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Xunming
authors.initials: X
authors.lastname: Ji
authors.affiliation: Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Shaochen
authors.initials: S
authors.lastname: Guan
authors.affiliation: Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Wu
authors.affiliation: Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Beibei
authors.initials: B
authors.lastname: Liu
authors.affiliation: Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Chunxiu
authors.initials: C
authors.lastname: Wang
authors.affiliation: Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhongying
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology*; D059168:Carotid Intima-Media Thickness; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D058226:Plaque, Atherosclerotic; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: carotid atherosclerosis; estimated glomerular filtration rate; intima–media thickness; kidney dysfunction