title: Pattern of childhood cancer in University College Hospital, Ibadan during 1991-2010 and comparison with the previous three decades.
abstract: BACKGROUND
  Cancer is an important cause of morbidity and mortality worldwide in children under 15 years of age, with the incidence and mortality rate varying from 40 to 155 per million children.
  
  
  OBJECTIVE
  To describe the pattern of childhood cancer in Ibadan, Nigeria.
  
  
  OBJECTIVE
  To compare the findings of this study with those of previous studies in Ibadan and internationally.
  
  
  METHODS
  A retrospective review of histologically and cytologically confirmed cases of cancer in children aged <15 years diagnosed at University College Hospital (UCH), Ibadan between January 1991 and December 2010 was undertaken. The cases were categorised using the International Classification of Childhood Cancer, third edition (ICCC-3).
  
  
  RESULTS
  There were 625 cases comprising 360 (57·6%) males with a modal age of 3 years. The most common neoplasms were lymphomas (140, 22·4%), of which 90% were non-Hodgkin lymphomas, with Burkitt lymphoma constituting the majority of cases (73). Other common neoplasms were retinoblastomas (21%), soft tissue sarcomas (14·9%), leukaemias (10·2%) and CNS tumours (6·9%). Lymphomas, bone tumours, malignant hepatic tumours and other malignant epithelial neoplasms had the highest mean and modal ages, while retinoblastomas, neuroblastomas, germ cell tumours and renal tumours had the lowest mean and modal ages. During 1960-72 there were 1326 cases and during 1973-90 there were 1881 cases and the proportion of lymphomas was 58·9% and 45·4%, respectively. The present study demonstrated a marked decline in the number of cases and proportion of lymphomas (22·4%), particularly Burkitt lymphomas.
  
  
  CONCLUSIONS
  During the last 20 years, there has been a decline in the number of cases of childhood cancer seen at UCH, Ibadan. This may be due to the establishment of additional specialist centres in the sub-region. Owing to a persistent decline in the frequency of Burkitt lymphoma, retinoblastoma is now the most common individual childhood cancer seen at Ibadan.
authors.forename: T O
authors.initials: TO
authors.lastname: Babatunde
authors.forename: E E U
authors.initials: EE
authors.lastname: Akang
authors.forename: G O
authors.initials: GO
authors.lastname: Ogun
authors.forename: B J
authors.initials: BJ
authors.lastname: Brown
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009369:Neoplasms / Q000453:epidemiology* / Q000473:pathology; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies
keywords: Childhood cancer,; Ibadan; Nigeria,; Pattern,