title: The Pyromaniac Inside You: Salmonella Metabolism in the Host Gut.
abstract: A metabolically diverse microbial community occupies all available nutrient-niches in the lumen of the mammalian intestine, making it difficult for pathogens to establish themselves in this highly competitive environment. Salmonella serovars sidestep the competition by using their virulence factors to coerce the host into creating a novel nutrient-niche. Inflammation-derived nutrients available in this new niche support a bloom of Salmonella serovars, thereby ensuring transmission of the pathogen to the next susceptible host by the fecal-oral route. Here we review the anaerobic food chain that characterizes resident gut-associated microbial communities along with the winning metabolic strategy Salmonella serovars use to edge out competing microbes in the inflamed intestine.
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California 95616; email: ajbaumler@ucdavis.edu.
authors.forename: Fabian
authors.initials: F
authors.lastname: Rivera-Chávez
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California 95616; email: ajbaumler@ucdavis.edu.
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Bäumler
mesh_terms: D000693:Anaerobiosis; D000818:Animals; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D056265:Microbial Interactions; D012480:Salmonella Infections / Q000382:microbiology / Q000473:pathology; D012486:Salmonella typhimurium / Q000254:growth & development* / Q000378:metabolism* / Q000472:pathogenicity; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D037521:Virulence Factors
keywords: anaerobic respiration; diarrhea; gastroenteritis; gastrointestinal pathogens; gut-associated microbial communities