title: [HIV/AIDS related mortality in southern Shanxi province and its risk factors].
abstract: OBJECTIVE
  To explore factors influencing mortality rate of HIV/AIDS and to improve the effectiveness of antiretroviral therapy (ART).
  
  
  METHODS
  By means of retrospective cohort study and the AIDS control information system, HIV/AIDS case reports and antiviral treatment information of 4 cities in southern Shanxi province up to end of December 2012 were selected, to calculate the mortality rate and treatment coverage based on further data collected, along with analysis using the Cox proportional hazards survival regression.
  
  
  RESULTS
  4 040 cases confirmed of HIV/AIDS were included in this study. The average age was (36.0 ± 12.9) years, with 65.3% being male, 56.5% being married, 73.5% having junior high school education or lower, 58.4% being peasants, 54.3% with sexually transmitted infection (40.1% were heterosexual, 14.2% were homosexual), and 38.9% were infected via blood transmission (20.2% were former plasma donors, 16.2% blood transfusion or products recipients, 2.4% were injection drug users). Overall mortality decreased from 40.2 per 100 person/year in 2004 to 6.3 per 100 person/year in 2012, with treatment coverage concomitantly increasing from almost 14.8% to 63.4%. Cox proportional hazards survival regression was used on 4 040 qualified cases, demonstrating the top mortality risk factor was without antiretroviral therapy (RR = 14.9, 95% CI: 12.7-17.4). Cox proportional hazards survival regression was made on 1 938 cases of antiviral treatment, demonstrating that the mortality risk of underweight or obese before treatment was higher than those of normal and overweight cases (RR = 2.7, 95% CI: 1.6-4.5), and the mortality of those having a CD4(+) T-lymphocyte count ≤ 50 cells per µl before treatment was more than 50 cases (RR = 2.6, 95% CI: 1.5-4.5); Cox proportional hazards survival regression was made on 2 102 cases of untreated cases, demonstrating the mortality risk of those initially diagnosed as AIDS was higher than those initially diagnosed as HIV (RR = 3.4, 95% CI: 2.9-4.0).
  
  
  CONCLUSIONS
  The ART could successfully make lower HIV/AIDS mortality rate, indicating effective ART can further decrease mortality.
authors.affiliation: Yuncheng Center for Disease Control and Prevention, Yuncheng 044000, China.
authors.forename: Shaoping
authors.initials: S
authors.lastname: Ning
authors.affiliation: Shanxi Provincial Center for Disease Control and Prevention.
authors.forename: Zidong
authors.initials: Z
authors.lastname: Xue
authors.affiliation: Yuncheng Center for Disease Control and Prevention, Yuncheng 044000, China; Email: 0359-2052102@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
authors.affiliation: Shanxi Provincial Center for Disease Control and Prevention.
authors.forename: Shengcai
authors.initials: S
authors.lastname: Mu
authors.affiliation: Shanxi Provincial Center for Disease Control and Prevention.
authors.forename: Yajuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Yuncheng Center for Disease Control and Prevention, Yuncheng 044000, China.
authors.forename: Shaoxian
authors.initials: S
authors.lastname: Jia
authors.affiliation: Institutes of Biomedical Sciences Fudan University and Shanghai Public Health Clinical Center.
authors.forename: Chao
authors.initials: C
authors.lastname: Qiu
authors.affiliation: Institutes of Biomedical Sciences Fudan University and Shanghai Public Health Clinical Center.
authors.forename: Jianqing
authors.initials: J
authors.lastname: Xu
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality*; D000328:Adult; D019380:Anti-HIV Agents; D000998:Antiviral Agents; D001782:Blood Donors; D001803:Blood Transfusion; D002947:Cities; D015331:Cohort Studies; D003141:Communicable Diseases; D005260:Female; D020010:Heterosexuality; D006716:Homosexuality; D006801:Humans; D008297:Male; D008393:Marriage; D008875:Middle Aged; D009765:Obesity; D050177:Overweight; D012189:Retrospective Studies; D012306:Risk; D012307:Risk Factors; D013851:Thinness; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents