title: Proton microbeam radiotherapy with scanned pencil-beams--Monte Carlo simulations.
abstract: Irradiation, delivered by a synchrotron facility, using a set of highly collimated, narrow and parallel photon beams spaced by 1 mm or less, has been termed Microbeam Radiation Therapy (MRT). The tolerance of healthy tissue after MRT was found to be better than after standard broad X-ray beams, together with a more pronounced response of malignant tissue. The microbeam spacing and transverse peak-to-valley dose ratio (PVDR) are considered to be relevant biological MRT parameters. We investigated the MRT concept for proton microbeams, where we expected different depth-dose profiles and PVDR dependences, resulting in skin sparing and homogeneous dose distributions at larger beam depths, due to differences between interactions of proton and photon beams in tissue. Using the FLUKA Monte Carlo code we simulated PVDR distributions for differently spaced 0.1 mm (sigma) pencil-beams of entrance energies 60, 80, 100 and 120 MeV irradiating a cylindrical water phantom with and without a bone layer, representing human head. We calculated PVDR distributions and evaluated uniformity of target irradiation at distal beam ranges of 60-120 MeV microbeams. We also calculated PVDR distributions for a 60 MeV spread-out Bragg peak microbeam configuration. Application of optimised proton MRT in terms of spot size, pencil-beam distribution, entrance beam energy, multiport irradiation, combined with relevant radiobiological investigations, could pave the way for hypofractionation scenarios where tissue sparing at the entrance, better malignant tissue response and better dose conformity of target volume irradiation could be achieved, compared with present proton beam radiotherapy configurations.
authors.affiliation: Institute of Nuclear Physics Polish Academy of Sciences, Radzikowskiego 152, PL 31-342 Kraków, Poland. Electronic address: Magdalena.Klodowska@ifj.edu.pl.
authors.forename: M
authors.initials: M
authors.lastname: Kłodowska
authors.affiliation: Institute of Nuclear Physics Polish Academy of Sciences, Radzikowskiego 152, PL 31-342 Kraków, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Olko
authors.affiliation: Institute of Nuclear Physics Polish Academy of Sciences, Radzikowskiego 152, PL 31-342 Kraków, Poland; The Marie-Skłodowska-Curie Centre of Oncology, Kraków Division, Kraków, Poland.
authors.forename: M P R
authors.initials: MP
authors.lastname: Waligórski
mesh_terms: D065638:Absorption, Radiation; D000818:Animals; D001932:Brain Neoplasms / Q000532:radiotherapy*; D003198:Computer Simulation; D019583:Dose Fractionation, Radiation; D004867:Equipment Design; D019317:Evidence-Based Medicine; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D059351:Organ Sparing Treatments / Q000379:methods*; D061766:Proton Therapy / Q000379:methods*; D011882:Radiotherapy, High-Energy / Q000009:adverse effects / Q000379:methods*; D013673:Technology Assessment, Biomedical; D016896:Treatment Outcome
keywords: Microbeam radiation therapy; Monte Carlo simulations; Proton radiotherapy