title: Influence of the previous use of β-blockers on the early clinical course of acute coronary syndromes.
abstract: Recent studies have recently questioned the current role of β-blockers in myocardial infarction. Our purpose is to analyze the influence of the previous use of β-blockers on the early course of patients admitted because of acute coronary syndrome (ACS). We analyzed the data of 37.359 patients included in the ARIAM-Andalucia Registry. Of them, 7759 (20.8%) were previously receiving β-blockers. BB patients were older, more often female, had more risk factors and vascular disease, and less often had an ST-elevation myocardial infarction. In the unadjusted analysis, BB patients less often had ventricular fibrillation or atrioventricular block, and more often a Killip classification >1, and no difference of in-hospital mortality (5.7 vs 5.6%). After logistic regression analysis and propensity score matching, no differences in complications or mortality (odds ratio 0.997, 95% confidence interval 0.882-1.128) were found in relationship to previous β-blockers. In conclusion, we find that the previous administration of β-blockers is not an independent predictor of the early prognosis of ACS.
authors.affiliation: Unidad Coronaria, Cardiology Department, Virgen Macarena University Hospital, Avenida Dr Fedriani, sn, E41008, Seville, Spain. grubira@wanadoo.es.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Garcia-Rubira
authors.affiliation: Unidad Coronaria, Cardiology Department, Virgen Macarena University Hospital, Avenida Dr Fedriani, sn, E41008, Seville, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Almendro-Delia
authors.affiliation: Unidad Coronaria, Cardiology Department, Virgen Macarena University Hospital, Avenida Dr Fedriani, sn, E41008, Seville, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Calvo-Taracido
authors.affiliation: Unidad Coronaria, Cardiology Department, Virgen Macarena University Hospital, Avenida Dr Fedriani, sn, E41008, Seville, Spain.
authors.forename: Emilia
authors.initials: E
authors.lastname: Blanco-Ponce
authors.affiliation: Unidad Coronaria, Cardiology Department, Virgen Macarena University Hospital, Avenida Dr Fedriani, sn, E41008, Seville, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Bastos-Amador
authors.affiliation: Intensive Care Unit, Virgen de las Nieves Hospital, Granada, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Reina-Toral
authors.affiliation: Unidad Coronaria, Cardiology Department, Virgen Macarena University Hospital, Avenida Dr Fedriani, sn, E41008, Seville, Spain.
authors.forename: Roman
authors.initials: R
authors.lastname: Calvo-Jambrina
authors.affiliation: Unidad Coronaria, Cardiology Department, Virgen Macarena University Hospital, Avenida Dr Fedriani, sn, E41008, Seville, Spain.
authors.forename: José Maria
authors.initials: JM
authors.lastname: Cruz-Fernández
authors.affiliation: Intensive Care Unit, Virgen de la Victoria Hospital, Málaga, Spain.
authors.forename: Angel
authors.initials: A
authors.lastname: Garcia-Alcántara
authors.affiliation: Unidad Coronaria, Cardiology Department, Virgen Macarena University Hospital, Avenida Dr Fedriani, sn, E41008, Seville, Spain.
authors.forename: Rafael
authors.initials: R
authors.lastname: Hidalgo-Urbano
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy* / Q000401:mortality; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000627:therapeutic use*; D000368:Aged; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality*; D057216:Propensity Score; D012307:Risk Factors
chemical_list: D000319:Adrenergic beta-Antagonists
keywords: Acute coronary syndrome; Myocardial infarction; Outcomes; β-Blockers