title: Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.
abstract: Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into the clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.
authors.affiliation: From the Department of Chemical and Systems Biology, Stanford University School of Medicine, CA.
authors.forename: Opher S
authors.initials: OS
authors.lastname: Kornfeld
authors.affiliation: From the Department of Chemical and Systems Biology, Stanford University School of Medicine, CA.
authors.forename: Sunhee
authors.initials: S
authors.lastname: Hwang
authors.affiliation: From the Department of Chemical and Systems Biology, Stanford University School of Medicine, CA.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Disatnik
authors.affiliation: From the Department of Chemical and Systems Biology, Stanford University School of Medicine, CA.
authors.forename: Che-Hong
authors.initials: CH
authors.lastname: Chen
authors.affiliation: From the Department of Chemical and Systems Biology, Stanford University School of Medicine, CA.
authors.forename: Nir
authors.initials: N
authors.lastname: Qvit
authors.affiliation: From the Department of Chemical and Systems Biology, Stanford University School of Medicine, CA. mochly@stanford.edu.
authors.forename: Daria
authors.initials: D
authors.lastname: Mochly-Rosen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D008954:Models, Biological; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species
keywords: mitochondria; mitochondrial degradation; mitochondrial dynamics; protein kinase C; reactive oxygen species