title: Fluid-structure interaction analysis of pulsatile flow within a layered and stenotic aorta.
abstract: In this paper, the hemodynamic characteristics of blood flow and stress distribution in a layered and stenotic aorta are investigated. By introducing symmetrical and unsymmetrical stenosis, the influence of stenosis morphology and stenotic ratio on the coupled dynamic responses of aorta is clarified. In the analysis, the in-vivo pulsatile waveforms and fully fluid-structure interaction (FSI) between the layered elastic aorta and the blood are considered. The results show that the fluid domain is abnormal in the stenotic aorta, and the whirlpool forms at the obstructed and downstream unobstructed regions. The maximum wall shear stresses appear at the throat of the stenosis. Downstream region appears low and oscillated shear stresses. In addition, along with the increase of the stenotic ratio, the amplitude of the maximum shear stress will be intensively increased and localized, and the sensitivity is also increased. In the aorta with unsymmetrical stenosis, the Von Mises stresses reach the peak value at the side with the surface protuberance, but they are reduced at the side with no protuberance. The sign variation of the layer interface shear stresses near the throat indicates the variation of the shear direction which increases the opportunity of shear damage at the transition plane. Moreover, the shear stress levels at the fluid-solid and intima-media interfaces are higher than that at the media-adventitia interface. The unsymmetrical stenosis causes higher stresses at the side with the surface protuberance than symmetrical one, but lower at the side with no protuberance. These results provide an insight in the influence of the stenosis, as well as its morphology, on the pathogenesis and pathological evolution of some diseases, such as arteriosclerosis and aortic dissection.
authors.forename: Zheng-qi
authors.initials: ZQ
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Tian-tian
authors.initials: TT
authors.lastname: Liu
authors.forename: Qing-shan
authors.initials: QS
authors.lastname: Yang
mesh_terms: D001011:Aorta / Q000503:physiopathology* / Q000648:ultrastructure; D001014:Aortic Aneurysm / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000209:etiology / Q000503:physiopathology*; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D013314:Stress, Mechanical