title: Particle-based technologies for osteoarthritis detection and therapy.
abstract: Osteoarthritis (OA) is a disease characterized by degradation of joints with the development of painful osteophytes in the surrounding tissues. Currently, there are a limited number of treatments for this disease, and many of these only provide temporary, palliative relief. In this review, we discuss particle-based drug delivery systems that can provide targeted and sustained delivery of imaging and therapeutic agents to OA-affected sites. We focus on technologies such as polymeric micelles and nano-/microparticles, liposomes, and dendrimers for their potential treatment and/or diagnosis of OA. Several promising studies are highlighted, motivating the continued development of delivery technologies to improve treatments for OA.
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
authors.forename: Taylor E
authors.initials: TE
authors.lastname: Kavanaugh
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Werfel
authors.affiliation: University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: Hongsik
authors.initials: H
authors.lastname: Cho
authors.affiliation: University of Tennessee Health Science Center, Memphis, TN, USA.
authors.forename: Karen A
authors.initials: KA
authors.lastname: Hasty
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA. craig.duvall@vanderbilt.edu.
authors.forename: Craig L
authors.initials: CL
authors.lastname: Duvall
mesh_terms: D000818:Animals; D055252:Cell-Derived Microparticles; D003692:Delayed-Action Preparations / Q000008:administration & dosage*; D050091:Dendrimers / Q000008:administration & dosage / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage / Q000627:therapeutic use; D008823:Micelles; D053758:Nanoparticles / Q000008:administration & dosage / Q000627:therapeutic use; D010003:Osteoarthritis / Q000175:diagnosis* / Q000188:drug therapy*
chemical_list: D003692:Delayed-Action Preparations; D050091:Dendrimers; D008081:Liposomes; D008823:Micelles
keywords: Controlled release; Drug delivery; Drug targeting; Osteoarthritis