title: BMP-2-induced Neuroforaminal Bone Growth in the Setting of a Minimally Invasive Transforaminal Lumbar Interbody Fusion.
abstract: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has become a popular alternative to traditional methods of lumbar decompression and fusion. When compared with the open technique, the minimally invasive approach can result in decreased pain and blood loss as well as a shorter length of hospitalization. However, the narrower working channel through the tubular retractor increases the difficulty of decortication and bone grafting. Therefore, recombinant human bone morphogenetic proteins (rhBMP-2) is often utilized (although this is off-label) to create a more favorable interbody fusion environment. Recently, the use of rhBMP-2 has been associated with excessive bone growth in an MIS-TLIF. If this bone growth compresses the neighboring neural structures, patients may present with either new or recurrent radicular pain. Computed tomographic (CT) imaging can demonstrate heterotopic bone growth extending from the disk space into either the ipsilateral neuroforamen or lateral recess, which may result in the compression of the exiting or traversing root, respectively. The purpose of this article and the accompanying video is to demonstrate a technique for defining and resecting rhBMP-2-induced heterotopic bone growth following a previous MIS-TLIF.
authors.affiliation: Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.
authors.forename: Junyoung
authors.initials: J
authors.lastname: Ahn
authors.forename: Ehsan
authors.initials: E
authors.lastname: Tabaraee
authors.forename: Kern
authors.initials: K
authors.lastname: Singh
mesh_terms: D001846:Bone Development / Q000187:drug effects*; D055396:Bone Morphogenetic Protein 2 / Q000627:therapeutic use*; D019299:Decompression, Surgical; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D008161:Lumbosacral Region / Q000601:surgery; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D019637:Orthopedic Procedures / Q000379:methods*; D013123:Spinal Fusion / Q000379:methods*; D013126:Spinal Nerve Roots / Q000601:surgery; D013131:Spine / Q000473:pathology / Q000601:surgery
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2