title: Treatment with interferon-alpha delays disease in swine infected with a highly virulent CSFV strain.
abstract: Interferon-alpha (IFNα) can effectively inhibit or abort a viral infection within the host. It has been reported that IFN induction and production is hindered during classical swine fever virus (CSFV) infection. Most of those studies have been performed in vitro, making it difficult to elucidate the actual role of IFNs during CSFV infection in swine. Here, we report the effect of IFNα treatment (delivered by a replication defective recombinant human adenovirus type 5, Ad5) in swine experimentally infected with highly virulent CSFV strain Brescia. Treatment with two different subtypes of IFNα delayed the appearance of CSF-related clinical signs and virus replication although it did not prevent lethal disease. This is the first report describing the effect of IFNα treatment during CSFV infection in swine.
authors.affiliation: Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA; Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269, USA; Plum Island Animal Disease Center, DHS, Greenport, NY 11944, USA. Electronic address: ignacio.fernandez-sainz@ars.usda.gov.
authors.forename: I
authors.initials: I
authors.lastname: Fernandez-Sainz
authors.affiliation: Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA; Plum Island Animal Disease Center, DHS, Greenport, NY 11944, USA. Electronic address: palaniappan.ramanathan@ars.usda.gov.
authors.forename: P
authors.initials: P
authors.lastname: Ramanathan
authors.affiliation: Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA; Department of Pathobiology and Veterinary Science, University of Connecticut, Storrs, CT 06269, USA; Plum Island Animal Disease Center, DHS, Greenport, NY 11944, USA. Electronic address: vivian.odonnell@uconn.edu.
authors.forename: V
authors.initials: V
authors.lastname: O'Donnell
authors.affiliation: Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA; Plum Island Animal Disease Center, DHS, Greenport, NY 11944, USA. Electronic address: fayna.sansegundo@ars.usda.gov.
authors.forename: F
authors.initials: F
authors.lastname: Diaz-San Segundo
authors.affiliation: Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA; Plum Island Animal Disease Center, DHS, Greenport, NY 11944, USA. Electronic address: lauro.velazquez@ars.usda.gov.
authors.forename: L
authors.initials: L
authors.lastname: Velazquez-Salinas
authors.affiliation: Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA; Plum Island Animal Disease Center, DHS, Greenport, NY 11944, USA. Electronic address: diego.sturza@ars.usda.gov.
authors.forename: D F
authors.initials: DF
authors.lastname: Sturza
authors.affiliation: Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA; Plum Island Animal Disease Center, DHS, Greenport, NY 11944, USA. Electronic address: james.zhu@ars.usda.gov.
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA; Plum Island Animal Disease Center, DHS, Greenport, NY 11944, USA. Electronic address: teresa.delossantos@ars.usda.gov.
authors.forename: T
authors.initials: T
authors.lastname: de los Santos
authors.affiliation: Plum Island Animal Disease Center, ARS, USDA, Greenport, NY 11944, USA; Plum Island Animal Disease Center, DHS, Greenport, NY 11944, USA. Electronic address: manuel.borca@ars.usda.gov.
authors.forename: M V
authors.initials: MV
authors.lastname: Borca
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D006691:Classical Swine Fever / Q000276:immunology / Q000473:pathology* / Q000517:prevention & control*; D006692:Classical Swine Fever Virus / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage*; D016019:Survival Analysis; D013552:Swine; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha
keywords: Classical swine fever virus; Interferon type I; Protection