title: A new trichostatin analog from Streptomyces sp. CPCC 203909.
abstract: A new trichostatin analog (1) and two known analogs (2, 3) have been isolated from the rice fermentation of the Streptomyces sp. CPCC 203909. Their structures were determined by spectroscopic and chemical methods. The absolute configurations of 1 were assigned by Marfey's method, combined with comparing the NMR and circular dichroism spectroscopic data of 2 and 3. Compound 1 showed cytotoxicity against human embryonic kidney 293 cell line with IC50 value of 39.2 μM.
authors.affiliation: a Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Chen
authors.forename: Ye-Xiang
authors.initials: YX
authors.lastname: Wu
authors.forename: Yan-Ni
authors.initials: YN
authors.lastname: Xu
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Yu
authors.forename: Bin
authors.initials: B
authors.lastname: Hong
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Shu-Yi
authors.initials: SY
authors.lastname: Si
mesh_terms: D005285:Fermentation; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry / Q000302:isolation & purification*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D006877:Hydroxamic Acids; C012589:trichostatin A
keywords: Marfey's method; Streptomyces sp; circular dichroism spectroscopic data; cytotoxicity; trichostatin analog