title: Psychopharmacological treatment of delirium: does earlier treatment and scheduled dosing improve outcomes?
abstract: OBJECTIVE
  The goals of this study were to examine how dosing strategies and timeliness of antipsychotic medication initiation would affect delirium duration.
  
  
  METHODS
  This is a retrospective paper and electronic record review of patients in an academic hospital who had been diagnosed with delirium. Forty-two patients met inclusion criteria. Quantitative and qualitative data on the course of delirium was gathered, as well as important demographic and medical variables.
  
  
  RESULTS
  There were no significant differences in duration of delirium between the scheduled and PRN groups using survival analysis, although the test was marginally significant (log rank test, p<0.06). Those who received treatment within 24 hours of recognition had significantly shorter durations of delirium compared to those who began treatment after 24 hours (log rank test, p<0.006).
  
  
  CONCLUSIONS
  These data suggest that early psychopharmacological treatment of delirium can reduce duration. Future research needs to investigate prompt and scheduled medication dosing strategies for treatment of delirium symptoms.
authors.affiliation: Assistant Professor of Psychiatry in the Department of Psychiatry and Behavioral Health Sciences at Tulane University School of Medicine.
authors.forename: Ashley
authors.initials: A
authors.lastname: Weiss
authors.affiliation: Dr. Scheeringa holds the Remigio Gonzalez, MD Professorship of Child Psychiatry at Tulane University School of Medicine.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Scheeringa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D003693:Delirium / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents