title: Synthesis and antiproliferative activity of some novel benzo-fused imidazo[1,8]naphthyridinones.
abstract: A number of new substituted fused naphthyridinones has been prepared and their antiproliferative activity was evaluated against a panel of seven human tumor cell lines, including the variant MES-SA/Dx5, reported to be 100-fold resistant to doxorubicin. Certain derivatives exhibited interesting cytotoxic properties, possessing IC50 values in a low μM range.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
authors.forename: Vassiliki
authors.initials: V
authors.lastname: Giannouli
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
authors.forename: Ioannis K
authors.initials: IK
authors.lastname: Kostakis
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece. Electronic address: pouli@pharm.uoa.gr.
authors.forename: Nicole
authors.initials: N
authors.lastname: Pouli
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Marakos
authors.affiliation: Department of Animal & Human Physiology, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece.
authors.forename: Pinelopi
authors.initials: P
authors.lastname: Samara
authors.affiliation: Department of Animal & Human Physiology, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 15784, Greece.
authors.forename: Ourania
authors.initials: O
authors.lastname: Tsitsilonis
mesh_terms: D054831:Acridones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004317:Doxorubicin / Q000494:pharmacology; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D045325:HCT116 Cells; D006367:HeLa Cells; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D054831:Acridones; D000970:Antineoplastic Agents; D006575:Heterocyclic Compounds, 3-Ring; D004317:Doxorubicin
keywords: Acridines; Cytotoxicity; Imidazonaphthyridinones; Multi-drug resistance