title: [Mortality of hematology-oncology patients with neutropenia in intensivecare].
abstract: BACKGROUND
  Febrile neutropenia remains one of the most common reasons for hospital admission of patients with underlying oncologic disease. These patients have an up to 10-fold increased risk of developing sepsis, which often leads to these patients being transferred to the intensive care unit (ICU). The survival of neutropenic patients with sepsis in particular has improved in recent years, due to advanced therapy in intensive care (surviving sepsis campaign); however few large international studies of neutropenic cancer patients in the ICU are available.
  
  
  METHODS
  In a retrospective study, 59 episodes of neutropenic cancer patients in the internal medicine ICU at the University Hospital of Cologne over a period of 2 years were analyzed.
  
  
  RESULTS
  Pneumonia with or without sepsis are the main admission diagnoses of neutropenic cancer patients in the ICU. The mortality rate of these patients is very high (50.8 %). Pneumonia and sepsis, stem cell transplantation, mechanical ventilation, and acute renal failure with or without dialysis are correlated with mortality.
  
  
  CONCLUSIONS
  Cancer patients should be admitted immediately to the ICU if they have signs of sepsis for early monitoring and treatment. Neutropenic patients have an increased risk for infectious complications and a risk for sepsis with higher mortality rates.
authors.affiliation: Klinik I für Innere Medizin, Universitätsklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.
authors.forename: I
authors.initials: I
authors.lastname: Suárez
authors.affiliation: Klinik I für Innere Medizin, Universitätsklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.|Arbeitskreis iCHOP (Intensive Care in Hemato-Oncologic Patients) in der DGIIN, DGHO, FASIM, Köln, Deutschland.
authors.forename: B
authors.initials: B
authors.lastname: Böll
authors.affiliation: Klinik I für Innere Medizin, Universitätsklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.|Arbeitskreis iCHOP (Intensive Care in Hemato-Oncologic Patients) in der DGIIN, DGHO, FASIM, Köln, Deutschland.
authors.forename: A
authors.initials: A
authors.lastname: Shimabukuro-Vornhagen
authors.affiliation: Klinik III für Innere Medizin, Universitätsklinik Köln, Köln, Deutschland.
authors.forename: G
authors.initials: G
authors.lastname: Michels
authors.affiliation: Klinik I für Innere Medizin, Universitätsklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.|Arbeitskreis iCHOP (Intensive Care in Hemato-Oncologic Patients) in der DGIIN, DGHO, FASIM, Köln, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: von Bergwelt-Baildon
authors.affiliation: Klinik I für Innere Medizin, Universitätsklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland. matthias.kochanek@uk-koeln.de.|Arbeitskreis iCHOP (Intensive Care in Hemato-Oncologic Patients) in der DGIIN, DGHO, FASIM, Köln, Deutschland. matthias.kochanek@uk-koeln.de.
authors.forename: M
authors.initials: M
authors.lastname: Kochanek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D064146:Chemotherapy-Induced Febrile Neutropenia / Q000401:mortality* / Q000628:therapy; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000401:mortality*; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D007938:Leukemia / Q000188:drug therapy / Q000401:mortality; D008223:Lymphoma / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000401:mortality / Q000628:therapy; D011014:Pneumonia / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000401:mortality / Q000628:therapy; D013223:Statistics as Topic; D055815:Young Adult
keywords: Bateriemia; Cancer; Mortality; Sepsis; Stem cell transplantation