title: A comparative study of PCA, SIMCA and Cole model for classification of bioimpedance spectroscopy measurements.
abstract: Due to safety and low cost of bioimpedance spectroscopy (BIS), classification of BIS can be potentially a preferred way of detecting changes in living tissues. However, for longitudinal datasets linear classifiers fail to classify conventional Cole parameters extracted from BIS measurements because of their high variability. In some applications, linear classification based on Principal Component Analysis (PCA) has shown more accurate results. Yet, these methods have not been established for BIS classification, since PCA features have neither been investigated in combination with other classifiers nor have been compared to conventional Cole features in benchmark classification tasks. In this work, PCA and Cole features are compared in three synthesized benchmark classification tasks which are expected to be detected by BIS. These three tasks are classification of before and after geometry change, relative composition change and blood perfusion in a cylindrical organ. Our results show that in all tasks the features extracted by PCA are more discriminant than Cole parameters. Moreover, a pilot study was done on a longitudinal arm BIS dataset including eight subjects and three arm positions. The goal of the study was to compare different methods in arm position classification which includes all three synthesized changes mentioned above. Our comparative study on various classification methods shows that the best classification accuracy is obtained when PCA features are classified by a K-Nearest Neighbors (KNN) classifier. The results of this work suggest that PCA+KNN is a promising method to be considered for classification of BIS datasets that deal with subject and time variability.
authors.affiliation: School of Electrical Engineering and Computer Science, University of Ottawa, Canada. Electronic address: inejadgholi@gmail.com.
authors.forename: Isar
authors.initials: I
authors.lastname: Nejadgholi
authors.affiliation: School of Electrical Engineering and Computer Science, University of Ottawa, Canada.
authors.forename: Miodrag
authors.initials: M
authors.lastname: Bolic
mesh_terms: D000818:Animals; D058266:Dielectric Spectroscopy / Q000379:methods*; D006801:Humans; D008954:Models, Biological
keywords: Bioimpedance spectroscopy; Classification; Cole modeling; Principal Component Analysis; SIMCA