title: Nodulisporipyrones A-D, new bioactive α-pyrone derivatives from Nodulisporium sp.
abstract: Four new α-pyrone derivatives, nodulisporipyrones A-D (1-4), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (65-12-7-1) that was fermented with rice. The structures of 1-4 were elucidated by extensive spectroscopic analysis, and the absolute configurations were determined by modified Mosher's method and electronic circular dichroism experiments. Their antimicrobial activities against Staphylococcus aureus 209P, Escherichia coli ATCC0111, Aspergillus niger R330, and Candida albicans FIM709 were evaluated using a paper disk diffusion method. Nodulisporipyrones A-D (1-4) are the first α-pyrone derivatives from Nodulisporium fungi.
authors.affiliation: a Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou 510632 , China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhao
authors.forename: Chuan-Xi
authors.initials: CX
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Gao-Qian
authors.initials: GQ
authors.lastname: Wang
authors.forename: Qi-Chang
authors.initials: QC
authors.lastname: Zheng
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.forename: Yun-Yang
authors.initials: YY
authors.lastname: Lian
authors.forename: Feng
authors.initials: F
authors.lastname: Lin
authors.forename: Liang-Dong
authors.initials: LD
authors.lastname: Guo
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012275:Oryza / Q000378:metabolism; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013098:Xylariales / Q000737:chemistry*
chemical_list: D011753:Pyrones
keywords: Nodulisporium sp.; antimicrobial activity; endolichenic fungus; nodulisporipyrone; α-pyrone