title: Correlates of fractures in elderly, diabetic outpatients.
abstract: It is widely recognized that patients presenting diabetes are at increased risk for fractures. In a retrospective case-control study, 101 cases were selected from medical charts of outpatients older than 70 with diabetes mellitus and a fracture within the past 5 years. Glycosylated hemoglobin (HbA1c) had been measured within 4 months around the assessment. Each case was matched for sex and age with one control, diabetic patient with no fracture. HbA1c level was similar in both groups. Patients with fractures presented significantly lower BMIs than controls, and had a higher rate of declared osteoporosis and comorbidity. A small number of cases were using vitamin D supplements while more were treated with benzodiazepine, opiates and Selective serotonin reuptake inhibitors (SSRI). This study suggests that, rather than the tight control of blood glucose, other factors such as medication and comorbidity could be associated with fracture risk in elderly diabetics.
authors.affiliation: Department of Geriatrics, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles , Brussels, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Snacken
authors.forename: L
authors.initials: L
authors.lastname: Crenier
authors.forename: F
authors.initials: F
authors.lastname: Fery
authors.forename: J-P
authors.initials: JP
authors.lastname: Praet
authors.forename: T
authors.initials: T
authors.lastname: Pepersack
mesh_terms: D000368:Aged; D001530:Belgium / Q000453:epidemiology; D015992:Body Mass Index; D016022:Case-Control Studies; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D012189:Retrospective Studies
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Diabetes mellitus; Elderly; Fracture; Glycaemic control