title: Thymidylate synthase inspired biomodel reagent for the conversion of uracil to thymine.
abstract: Inspired by TSase catalysis for dUMP conversion to dTMP, a biomodel reagent is developed. The presence of NH2, Gly-(S)-Cys and (S)-oxiran methyl, at C5, C4 and N-10 of acridine, respectively, in addition to the pH of the reaction mixture, allows for good complementary inter- and intra-molecular interactions and chiral discrimination for the reagent to achieve conversion of uracil to thymine.
authors.affiliation: Department of Chemistry, UGC Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar-143005, India. palwinder_singh_2000@yahoo.com.
authors.forename: Palwinder
authors.initials: P
authors.lastname: Singh
authors.forename: Arun
authors.initials: A
authors.lastname: Kumar
authors.forename: Sukhmeet
authors.initials: S
authors.lastname: Kaur
authors.forename: Amrinder
authors.initials: A
authors.lastname: Singh
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D013940:Thymidylate Synthase / Q000378:metabolism*; D013941:Thymine / Q000737:chemistry*; D014498:Uracil / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D014498:Uracil; D013940:Thymidylate Synthase; D013941:Thymine