title: Coincidental finding of Fabry's disease in a patient with IgA nephropathy.
abstract: We present the case of a woman with IgA nephropathy and concomitant Fabry's disease. She was referred to our hospital with proteinuria and haematuria. A renal biopsy showed findings indicating IgA nephropathy under light and immunofluorescence microscopy. Electron microscopy, however, showed laminated inclusion bodies characteristic of Fabry's disease. The α-galactosidase activity in her serum was low, and the diagnosis of Fabry's disease was confirmed by genetic analysis. Fabry's disease in a patient with IgA nephropathy is a very rare occurrence, and Fabry's disease diagnosed only by electron microscopy has not been previously reported.
authors.affiliation: Department of Nephrology , Osaka Medical College , 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686 , Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kakita
authors.affiliation: Department of Nephrology , Osaka Medical College , 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686 , Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Nagatoya
authors.affiliation: Department of Nephrology , Osaka Medical College , 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686 , Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Mori
authors.affiliation: Department of Pediatrics , The Jikei University School of Medicine , 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461 , Japan.
authors.forename: Masahisa
authors.initials: M
authors.lastname: Kobayashi
authors.affiliation: Department of Nephrology , Osaka Medical College , 2-7 Daigaku-machi, Takatsuki, Osaka 569-8686 , Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Inoue
keywords: Fabry’s disease; IgA nephropathy; heterozygous female