title: Caveolin-1, breast cancer and ionizing radiation.
abstract: Breast cancer (BC) recovery has increased in recent years thanks to efforts of Omics-based research in this field. However, despite the important results obtained, BC remains a complex multifactorial pathology that is difficult to treat appropriately. Caveolin-1 (CAV1), the basic constituent protein of specialized plasma membrane invaginations called caveolae, is emerging as a potential therapeutic biomarker in BC. This factor may modulate BC response to chemotherapy and radiation therapy. In addition, recent reports describe the key role of CAV1 during cell response to oxidative stress. The aim of the present review was to describe the biological roles of CAV1 in BC considering its contrasting dual functions as an oncogene and as a tumor suppressor. In addition, we report on how CAV1 may contribute to tumor cell response to ionizing radiation treatment. Finally, new roles of CAV1 in BC both on epithelium and stroma may be useful as prognostic indicators for patient treatment and help clinicians in the selection of the best personalized therapy.
authors.affiliation: Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR) -LATO, Cefalù (PA), Italy.
authors.forename: Marzia
authors.initials: M
authors.lastname: Pucci
authors.affiliation: Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR) -LATO, Cefalù (PA), Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Bravatà
authors.affiliation: Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR) -LATO, Cefalù (PA), Italy.
authors.forename: Giusi Irma
authors.initials: GI
authors.lastname: Forte
authors.affiliation: Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR) -LATO, Cefalù (PA), Italy.
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: Cammarata
authors.affiliation: Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR) -LATO, Cefalù (PA), Italy Department of Health Sciences, Tecnomed Foundation, University of Milano-Bicocca, Milan, Italy Nuclear Medicine Center, San Gerardo Hospital, Monza, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Messa
authors.affiliation: Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR) -LATO, Cefalù (PA), Italy Department of Health Sciences, Tecnomed Foundation, University of Milano-Bicocca, Milan, Italy Nuclear Medicine, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Maria Carla
authors.initials: MC
authors.lastname: Gilardi
authors.affiliation: Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR) -LATO, Cefalù (PA), Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Minafra
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000628:therapy; D051242:Caveolin 1 / Q000235:genetics* / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000528:radiation effects; D006801:Humans; D058990:Molecular Targeted Therapy; D011839:Radiation, Ionizing; D011878:Radiotherapy
chemical_list: D014408:Biomarkers, Tumor; D051242:Caveolin 1; D066246:ErbB Receptors
keywords: CAV1; biomarker; breast cancer; ionizing radiation; review