title: A CRISPR View of Cleavage.
abstract: Seminal studies showed that CRISPR-Cas systems provide adaptive immunity in prokaryotes and promising gene-editing tools from bacteria to humans. Yet, reports diverged on whether some CRISPR systems naturally target DNA or RNA. Here, Samai and colleagues unify the studies, showing that a single type III CRISPR-Cas system cleaves both DNA and RNA targets, independently.
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA. Electronic address: ariel.weinberger@wyss.harvard.edu.
authors.forename: Ariel D
authors.initials: AD
authors.lastname: Weinberger
authors.affiliation: Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02115, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Gilmore
mesh_terms: D064113:CRISPR-Cas Systems; D013212:Staphylococcus epidermidis / Q000378:metabolism*