title: Lung cancer detection with digital chest tomosynthesis: first round results from the SOS observational study.
abstract: OBJECTIVE
  Baseline results of the Studio OSservazionale (SOS), observational study, a single-arm observational study of digital chest tomosynthesis for lung cancer detection in an at-risk population demonstrated a detection rate of lung cancer comparable to that of studies that used low dose CT scan (LDCT). We present the results of the first round.
  
  
  METHODS
  Totally 1,703 out of 1,843 (92%) subjects who had a baseline digital chest tomosynthesis underwent a first round reevaluation after 1 year.
  
  
  RESULTS
  At first round chest digital tomosynthesis, 13 (0.7%) subjects had an indeterminate nodule larger than 5 mm and underwent low-dose CT scan for nodule confirmation. PET/CT study was obtained in 10 (0.5%) subjects and 2 subjects had a low-dose CT follow up. Surgery, either video-assisted thoracoscopic or open surgery for indeterminate pulmonary nodules was performed in 10 (0.2%) subjects. A lung cancer was diagnosed and resected in five patients. The lung cancer detection rate at first round was 0.3% (5/1,703).
  
  
  CONCLUSIONS
  The detection rate of lung cancer at first round for tomosynthesis is comparable to rates reported for CT. In addition, results of first round digital chest tomosynthesis confirm chest tomosynthesis as a possible first-line lung cancer-screening tool.
authors.affiliation: 1 Thoracic Surgery Unit, Sacro Cuore - Don Calabria Research Hospital, Negrar Verona, Italy ; 2 Thoracic Surgery Unit, 3 Department of Radiology, S. Croce e Carle Hospital, Cuneo, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Bertolaccini
authors.affiliation: 1 Thoracic Surgery Unit, Sacro Cuore - Don Calabria Research Hospital, Negrar Verona, Italy ; 2 Thoracic Surgery Unit, 3 Department of Radiology, S. Croce e Carle Hospital, Cuneo, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Viti
authors.affiliation: 1 Thoracic Surgery Unit, Sacro Cuore - Don Calabria Research Hospital, Negrar Verona, Italy ; 2 Thoracic Surgery Unit, 3 Department of Radiology, S. Croce e Carle Hospital, Cuneo, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Tavella
authors.affiliation: 1 Thoracic Surgery Unit, Sacro Cuore - Don Calabria Research Hospital, Negrar Verona, Italy ; 2 Thoracic Surgery Unit, 3 Department of Radiology, S. Croce e Carle Hospital, Cuneo, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Priotto
authors.affiliation: 1 Thoracic Surgery Unit, Sacro Cuore - Don Calabria Research Hospital, Negrar Verona, Italy ; 2 Thoracic Surgery Unit, 3 Department of Radiology, S. Croce e Carle Hospital, Cuneo, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: Ghirardo
authors.affiliation: 1 Thoracic Surgery Unit, Sacro Cuore - Don Calabria Research Hospital, Negrar Verona, Italy ; 2 Thoracic Surgery Unit, 3 Department of Radiology, S. Croce e Carle Hospital, Cuneo, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Grosso
authors.affiliation: 1 Thoracic Surgery Unit, Sacro Cuore - Don Calabria Research Hospital, Negrar Verona, Italy ; 2 Thoracic Surgery Unit, 3 Department of Radiology, S. Croce e Carle Hospital, Cuneo, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Terzi
keywords: Lung cancer; digital chest tomosynthesis; early stage lung cancer; lung cancer screening