title: Chemotherapeutic agents for the treatment of hepatocellular carcinoma: efficacy and mode of action.
abstract: Hepatocellular carcinoma (HCC) is a dreaded malignancy that every year causes half a million deaths worldwide. Being an aggressive cancer, its incidence exceeds 700,000 new cases per year worldwide with a median survival of 6-8 months. Despite advances in prognosis and early detection, effective HCC chemoprevention or treatment strategies are still lacking, therefore its dismal survival rate remains largely unchanged. This review will characterize currently available chemotherapeutic drugs used in the treatment of HCC. The respective mode(s) of action, side effects and recommendations will be also described for each drug.
authors.affiliation: Department of Chemistry, Mansoura University , Egypt.
authors.forename: Saad
authors.initials: S
authors.lastname: Shaaban
authors.affiliation: Department of Biochemistry, Mansoura University , Egypt.
authors.forename: Amr
authors.initials: A
authors.lastname: Negm
authors.affiliation: Department of Zoology, Mansoura University , Egypt.
authors.forename: Elsayed E
authors.initials: EE
authors.lastname: Ibrahim
authors.affiliation: Department of Botany, Mansoura University , Egypt.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Elrazak
keywords: chemoresistance; hepatocellular carcinoma; liver cancer; molecular therapies