title: Thrombocytopaenia and neutropaenia associated with daptomycin USE.
abstract: Daptomycin is a lipopeptide antibiotic active against gram-positive bacteria indicated for the treatment of complicated skin and skin structure infections and Staphylococcus aureus bloodstream infections, including endocarditis. Thrombocytopaenia, but not neutropaenia, is described as a possible or probable adverse effect in the product information. Up to now, two case reports of daptomycin-induced thrombocytopaenia have been published and a single case of neutropaenia associated with prolonged daptomycin use. We report a case of simultaneous thrombocytopaenia and neutropaenia associated with prolonged daptomycin use for a culture-negative endocarditis.
authors.affiliation: a Anesthesiology Department , Hospital Universitario La Paz , Madrid , Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Leyra
authors.affiliation: a Anesthesiology Department , Hospital Universitario La Paz , Madrid , Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Perez-Chuliá
authors.affiliation: a Anesthesiology Department , Hospital Universitario La Paz , Madrid , Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Jofré
authors.affiliation: a Anesthesiology Department , Hospital Universitario La Paz , Madrid , Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Suarez-Gonzalo
authors.affiliation: a Anesthesiology Department , Hospital Universitario La Paz , Madrid , Spain.
authors.forename: Natalia Peña
authors.initials: NP
authors.lastname: Del Ser
authors.affiliation: a Anesthesiology Department , Hospital Universitario La Paz , Madrid , Spain.
authors.forename: Isidro
authors.initials: I
authors.lastname: Moreno
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D017576:Daptomycin / Q000009:adverse effects*; D059905:Endocarditis, Non-Infective / Q000188:drug therapy; D005260:Female; D006801:Humans; D009503:Neutropenia / Q000139:chemically induced*; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin
keywords: Cefepime; Daptomycin; Endocarditis; Neutropaenia; Thrombocytopaenia