title: [An assessment of association of thyroid volume with growth indicators and comparison of different thyroid volume indexes in school-aged children].
abstract: OBJECTIVE
  To analyze the association between thyroid volume and physical growth of school-age children, and to compare volume indexes of individual thyroids for reference of selection of assessment indicators.
  
  
  METHODS
  All the students of the 12 classes of grades 3-5 at a primary school in Minhang district, Shanghai were rounded up with a multi-stage cluster sampling, for physical examinations to measure their height, weight, Body mass index (BMI) and body surface area (BSA), followed by B-ultrasonography to measure their thyroid volume. Data of the measurements were calculated to learn their height corrected volume index (HVI), weight and height corrected volume index (WHVI), BMI corrected volume (BMIV), and BSA corrected volume (BSAV) individually. Their urine and salt samples were collected to measure iodine concentration in urine and salt. Individual indexes were studied for their association with the growth and development indexes of children.
  
  
  RESULTS
  Thyroid volume data were collected for 485 students, including 258 boys (53.2%) and 227 girls (46.8%). Their height, weight, BMI and BSA were found to be positively correlated with their age (P < 0.05). For children of the same age group, their thyroid volume was also positively correlated with their physical development indexes. Of all the thyroid indexes, the difference between BSAV physical development factors had no statistical association (with partial-correlation coefficients for age, gender, height, and weight being 0.07, 0.05, 0.01 and 0.02 respectively), and their thyroid volume, HVI, BMI and weight were correlated to age, height and weight.
  
  
  CONCLUSIONS
  Thyroid volume was associated with age and weight. It was inappropriate to diagnose goiter with criteria of age, gender and thyroid volume. BSAV was recommended for its non-association with age, gender and weight and its stability.
authors.affiliation: The Key Laboratory of Public Health Safety, Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200021, China.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention.
authors.forename: Pu
authors.initials: P
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Public Health Safety, Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200021, China; Email: zhaoqi@shmu.edu.cn.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: The Key Laboratory of Public Health Safety, Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200021, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention.
authors.forename: Hong
authors.initials: H
authors.lastname: Fang
authors.affiliation: The Key Laboratory of Public Health Safety, Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200021, China.
authors.forename: Chaowei
authors.initials: C
authors.lastname: Fu
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention.
authors.forename: Huilin
authors.initials: H
authors.lastname: Xu
authors.affiliation: The Key Laboratory of Public Health Safety, Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200021, China.
authors.forename: Hexing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Shanghai Minhang Center for Disease Control and Prevention.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Yan
authors.affiliation: The Key Laboratory of Public Health Safety, Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200021, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: The Key Laboratory of Public Health Safety, Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200021, China.
authors.forename: Qingwu
authors.initials: Q
authors.lastname: Jiang
mesh_terms: D015992:Body Mass Index; D001830:Body Surface Area; D001835:Body Weight; D002648:Child; D002681:China; D005260:Female; D006042:Goiter / Q000175:diagnosis*; D006801:Humans; D007454:Iodides; D007455:Iodine; D008297:Male; D009929:Organ Size; D017673:Sodium Chloride, Dietary; D013961:Thyroid Gland / Q000254:growth & development*
chemical_list: D007454:Iodides; D017673:Sodium Chloride, Dietary; D007455:Iodine