title: Association between single nucleotide polymorphisms in thrombospondins genes and coronary artery disease: A meta-analysis.
abstract: OBJECTIVE
  This study aimed to assess the association between single nucleotide polymorphisms in thrombospondin-1 (THBS1), thrombospondin-2 (THBS2), thrombospondin-4 (THBS4) and coronary artery disease (CAD) risk.
  
  
  METHODS
  Electronic databases were searched before June, 2014 to obtain articles associated with thrombospondin polymorphisms and CAD risk. After identifying case-control studies, odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to pool effect sizes. Different effect models were used according to heterogeneity. Meta-regression and sensitivity analyses were performed to examine the heterogeneity source. Begg's funnel plot and Egger's test were conducted for publication bias.
  
  
  RESULTS
  13 studies involving 10,801 cases and 9,381 controls were included. Associations were observed between the THBS1 N700S polymorphism and CAD risk in general population(heterozygote model: OR=1.14, 95% CI: 1.03-1.26; dominant model: OR=1.13, 95% CI: 1.00-1.29), European population (heterozygote model: OR=1.13, 95% CI: 1.00-1.27) and Asian population (heterozygote model: OR=1.57, 95% CI: 1.01-2.44; dominant model: OR=1.56, 95% CI: 1.00-2.43). The THBS2 3' untranslated region (UTR) polymorphism and THBS4 A387P polymorphism were not associated with overall CAD risk. However, an association was observed between the THBS4 A387P polymorphism and CAD risk in the American population (allele model: OR=1.09, 95% CI: 1.00-1.18; homozygote model: OR=1.29, 95% CI: 1.04-1.61; recessive model: OR=1.27, 95% CI: 1.02-1.58).
  
  
  CONCLUSIONS
  The THBS1 N700S polymorphism was associated with increased CAD risk, especially in Asian and European populations. No association was observed between the THBS2 3' UTR polymorphism and CAD risk. The THBS4 A387P polymorphism was associated with increased CAD risk in the American population.
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China.
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China; Department of Cardiology, Laiwu People's Hospital, Laiwu 271100,P.R. China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Wei
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China.
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Li
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China.
authors.forename: Ling-Li
authors.initials: LL
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China; Department of Geriatrics, Qilu Hospital of Shandong University; Key Laboratory of Cardiovascular Proteomics of Shandong Province, Ji'nan 250012, P.R. China.
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Wang
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China; Department of Emergency, Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China.
authors.forename: Meng-Xiong
authors.initials: MX
authors.lastname: Tang
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China. Electronic address: zhongmingzm@gmail.com.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D019700:Thrombospondin 1 / Q000235:genetics*; D019699:Thrombospondins / Q000235:genetics*; D000099262:Thrombospondin 2
chemical_list: D019700:Thrombospondin 1; D019699:Thrombospondins; D000099262:Thrombospondin 2; C101864:thrombospondin 4
keywords: Coronary artery disease; Meta-analysis; Singe nucleotide polymorphism; Thrombospondin