title: Transarterial approaches to primary and secondary hepatic malignancies.
abstract: Transarterial therapies in the setting of primary and secondary liver malignancies are becoming an essential part of the oncology landscape. Most patients with hepatic malignancies are not candidates for curative surgical intervention, thereby warranting exploration of alternative means of treatment that preserves quality of life while providing clinical benefit. Herein, the data for intra-arterial chemoinfusion, transarterial chemoembolization, drug-eluting beads, and radioembolization are discussed in the setting of malignancies within the liver; outcome data relating to survival, time-to-progression, time-to-recurrence, and adverse events are presented. Further data regarding different treatment paradigms for hepatocellular carcinoma, metastatic colorectal carcinoma, neuroendocrine tumours, and intrahepatic cholangiocarcinoma are also provided. In light of these and forthcoming data, transarterial therapies seem to offer a viable treatment pathway for select populations of patients.
authors.affiliation: Department of Radiology, Section of Interventional Radiology and Division of Interventional Oncology, Northwestern University, 676 North St Clair, Suite 800, Chicago, IL 60611, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Habib
authors.affiliation: Department of Radiology, Section of Interventional Radiology and Division of Interventional Oncology, Northwestern University, 676 North St Clair, Suite 800, Chicago, IL 60611, USA.
authors.forename: Kush
authors.initials: K
authors.lastname: Desai
authors.affiliation: Department of Radiology, Section of Interventional Radiology and Division of Interventional Oncology, Northwestern University, 676 North St Clair, Suite 800, Chicago, IL 60611, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Hickey
authors.affiliation: Department of Radiology, Section of Interventional Radiology and Division of Interventional Oncology, Northwestern University, 676 North St Clair, Suite 800, Chicago, IL 60611, USA.
authors.forename: Bartley
authors.initials: B
authors.lastname: Thornburg
authors.affiliation: Department of Radiology, Section of Interventional Radiology and Division of Interventional Oncology, Northwestern University, 676 North St Clair, Suite 800, Chicago, IL 60611, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Lewandowski
authors.affiliation: Department of Radiology, Section of Interventional Radiology and Division of Interventional Oncology, Northwestern University, 676 North St Clair, Suite 800, Chicago, IL 60611, USA.
authors.forename: Riad
authors.initials: R
authors.lastname: Salem
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D017115:Catheter Ablation / Q000379:methods; D016461:Chemoembolization, Therapeutic / Q000379:methods; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D018281:Cholangiocarcinoma / Q000628:therapy*; D015179:Colorectal Neoplasms / Q000628:therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D018358:Neuroendocrine Tumors / Q000556:secondary / Q000628:therapy; D011788:Quality of Life
chemical_list: D000970:Antineoplastic Agents