title: Severe short stature and Wolf-Hirschhorn syndrome: response to growth hormone in two cases without growth hormone deficiency.
abstract: Wolf-Hirschhorn syndrome (WHS) is a rare congenital disorder occurring in approximately 1/50 000 births, with marked pre- and postnatal growth failure. WHS results from the hemizygous deletion encompassing the 4p16.3 region. This report of two children with WHS shows that growth hormone treatment in selected children with WHS and severe short stature may have a substantial effect on long-term growth.
authors.affiliation: Brighton and Sussex Medical School , Brighton , UK.
authors.forename: Devon E
authors.initials: DE
authors.lastname: Austin
authors.affiliation: Department of Physiology , University of Auckland , Auckland , New Zealand ; Paediatric Endocrinologist , Starship Children's Hospital , Auckland , New Zealand.
authors.forename: Alistair J
authors.initials: AJ
authors.lastname: Gunn
authors.affiliation: Paediatric Endocrinologist , Starship Children's Hospital , Auckland , New Zealand.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Jefferies