title: The use of MMSE and MoCA in patients with acute ischemic stroke in clinical.
abstract: BACKGROUND
  The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) are brief cognitive screening tools that have been developed for the screening of patients with Mild Cognitive Impairment.
  
  
  METHODS
  A total of 105 patients were included in this study, aged 53-89 years, with acute ischemic stroke admitted to hospital and fell into two groups: stroke patients with cognitive impairment (SCI) and controls with no cognitive impairment (n-SCI). The patient's characteristics are collected and regression analyses were performed to predict cognitive impairments. We use MMSE and MoCA assessment as prognostic indices for cognitive impairments of patient's with stroke.
  
  
  OBJECTIVE
  Our aim was to examine the effectiveness of the MMSE and MoCA in screening cognitive impairments.
  
  
  RESULTS
  There were significant difference among the two groups in the prevalence of diabetes mellitus (p < 0.05) and intracranial atherosclerosis (p < 0.05). A linear regression determined that the age, diabetes, intracranial atherosclerosis predicted the cognitive impairments. The ROC results for MoCA with an AUC of 0.882 and the corresponding results for MMSE show a similar AUC of 0.839.
  
  
  CONCLUSIONS
  Neuropsychological performance of stroke patients was influenced by biological and demographic variables: age, diabetes and intracranial atherosclerosis. The MoCA and MMSE are both reliable assessments for the diagnosis of cognitive impairment after stroke.
authors.affiliation: a Department of Neurology, School of Medicine , Shanghai Jiao Tong University , Shanghai 200092 , China.|b Department of Neurology , Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200092 , China.
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Shen
authors.affiliation: c Department of Neurology , Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine , Chongming Branch , Shanghai 202150 , China.
authors.forename: Wen-An
authors.initials: WA
authors.lastname: Wang
authors.affiliation: d Center for Stem Cell and Nanomedicine, Laboratory for System Biology , Shanghai Advanced Research Institute, Chinese Academy of Sciences , Shanghai 201210 , China.
authors.forename: Fu-De
authors.initials: FD
authors.lastname: Huang
authors.affiliation: b Department of Neurology , Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200092 , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.affiliation: a Department of Neurology, School of Medicine , Shanghai Jiao Tong University , Shanghai 200092 , China.|b Department of Neurology , Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200092 , China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Liu
authors.affiliation: a Department of Neurology, School of Medicine , Shanghai Jiao Tong University , Shanghai 200092 , China.|b Department of Neurology , Xin Hua Hospital affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200092 , China.
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Xia
authors.affiliation: a Department of Neurology, School of Medicine , Shanghai Jiao Tong University , Shanghai 200092 , China.|e Department of Neurology , The Sixth People's Hospital affiliated to Shanghai Jiaotong University School of Medicine , Shanghai 200233 , China.
authors.forename: Meng
authors.initials: M
authors.lastname: Han
authors.affiliation: d Center for Stem Cell and Nanomedicine, Laboratory for System Biology , Shanghai Advanced Research Institute, Chinese Academy of Sciences , Shanghai 201210 , China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000150:complications* / Q000523:psychology; D003071:Cognition / Q000502:physiology*; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000209:etiology / Q000523:psychology; D003920:Diabetes Mellitus / Q000523:psychology; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D020521:Stroke / Q000150:complications* / Q000523:psychology
keywords: MMSE; MoCA; acute ischemic stroke