title: Cell-targeted platinum nanoparticles and nanoparticle clusters.
abstract: Herein, we report the facile preparation of cell-targeted platinum nanoparticles (PtNPs), through the design of peptides that, as a single molecule added in small concentration during the synthesis, control the size of PtNP clusters during their growth, stabilise the PtNPs in aqueous suspension and enable the functionalisation of the PtNPs with a versatile range of cell-targeting ligands. Water-soluble PtNPs targeted respectively at blood group antigens and at integrin receptors are demonstrated.
authors.affiliation: The MacDiarmid Institute for Advanced Materials and Nanotechnology, School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1123, New Zealand. m.brimble@auckland.ac.nz david.williams@auckland.ac.nz.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Papst
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Brimble
authors.forename: Clive W
authors.initials: CW
authors.lastname: Evans
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Verdon
authors.forename: Vaughan
authors.initials: V
authors.lastname: Feisst
authors.forename: P Rod
authors.initials: PR
authors.lastname: Dunbar
authors.forename: Richard D
authors.initials: RD
authors.lastname: Tilley
authors.forename: David E
authors.initials: DE
authors.lastname: Williams
mesh_terms: D016475:3T3 Cells / Q000187:drug effects; D000818:Animals; D001671:Biochemistry / Q000379:methods*; D001789:Blood Group Antigens / Q000378:metabolism; D003208:Concanavalin A / Q000737:chemistry; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D046529:Microscopy, Electron, Transmission; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D010984:Platinum / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D012995:Solubility
chemical_list: D001789:Blood Group Antigens; D039302:Integrin alphaVbeta3; D008024:Ligands; D010455:Peptides; D003208:Concanavalin A; D010984:Platinum