title: Serum oxidant and antioxidant status of patients with chronic tension-type headache: possible effects of medical treatment.
abstract: Tension-type headache (TTH) is one of the most common and costly primary types of headache in clinical practice, with an unknown etiology. This study assessed to investigate oxidative and antioxidative status in patients with chronic tension-type headache (CTTH), and to evaluate possible effect of medical treatment. The study included 41 CTTH patients and 19 age- and sex-matched healthy subjects without headache as controls. The CTTH group comprised 20 patients receiving treatment and 21 untreated patients. We evaluated oxidant/antioxidant status by measuring serum malondialdehyde (MDA) levels and activities of antioxidant enzymes, namely glutathione peroxidase (GSH-Px) and catalase (CAT). Comparison of oxidative parameters in the patient and control groups revealed significantly lower CAT activities and higher MDA level and GSH-Px activities in the patient group. In the CTTH group, serum CAT activities were found to be significantly decreased in patient groups, while serum MDA levels and GSH-Px activities were found to be higher in the untreated CTTH patients. These findings suggest that oxidative stress is increased in the patients with CTTH, and medical treatment abolishes the stress in part. It has been concluded that antioxidant support might be helpful for the patients with CTTH to prevent oxidant stress and peroxidation damages further.
authors.affiliation: Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey. gokceburcu@gmail.com.
authors.forename: Burcu
authors.initials: B
authors.lastname: Gökçe Çokal
authors.affiliation: Ministry of Health, Directorate of Health Services, Ankara, Turkey. aytacbilal@hotmail.com.
authors.forename: Bilal
authors.initials: B
authors.lastname: Aytaç
authors.affiliation: Biochemistry Laboratory, Public Health Institute of Turkey, Ankara, Turkey. zaesrad@hotmail.com.
authors.forename: Zahide Esra
authors.initials: ZE
authors.lastname: Durak
authors.affiliation: Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey. gokcegunes@yahoo.com.
authors.forename: Hafize Nalan
authors.initials: HN
authors.lastname: Güneş
authors.affiliation: Department of Biochemistry, Selçuk University Faculty of Medicine, Konya, Turkey. bahadirozturk@selcuk.edu.tr.
authors.forename: Bahadır
authors.initials: B
authors.lastname: Öztürk
authors.affiliation: Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey. keskinselda@gmail.com.
authors.forename: Selda
authors.initials: S
authors.lastname: Keskin Güler
authors.affiliation: Department of Biochemistry, Ankara University Faculty of Medicine , Ankara, Turkey. ilker_durak@yahoo.com.
authors.forename: İlker
authors.initials: İ
authors.lastname: Durak
authors.affiliation: Department of Neurology, Ankara Education and Research Hospital, Ankara, Turkey. tahir.yoldas@gmail.com.
authors.forename: Tahir Kurtuluş
authors.initials: TK
authors.lastname: Yoldaş
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism; D001774:Blood Chemical Analysis; D002374:Catalase / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D018781:Tension-Type Headache / Q000097:blood* / Q000188:drug therapy*
chemical_list: D000928:Antidepressive Agents; D000975:Antioxidants; D016877:Oxidants; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase
keywords: Catalase; Glutathione peroxidase; Malondialdehyde; Oxidative stress; Tension-type headache; Treatment