title: [Podocyturia in pregnant women with chronic hypertension may predict kidney injury?].
abstract: OBJECTIVE
  To evaluate the presence of podocyturia in chronic hypertensive pregnant women in the third trimester of pregnancy and its possible association with renal disease.
  
  
  METHODS
  This was an observational study of a convenience sample of 38 chronic hypertensive pregnant women. The podocytes were labeled by the indirect immunofluorescence technique with anti-podocin and diamidino-phenylindole (DAPI). The count was made on 30 random fields analyzed and corrected according to urinary creatinine (podocytes/mg creatinine). The patients were assigned to two groups: NG (normal glomerular function), up to 100 podocytes, and GP (probable glomerulopathy), more than 100 podocytes. Urinary creatinine was measured by the alkaline picrate method. The variables analyzed were body mass index, gestational age, and systolic and diastolic blood pressure at the time of sample collection. Data were analyzed using the SPSS - version 16.0 (IBM - USA). Statistical analysis was performed by the χ2 test, and significant differences were considered when p<0.05.
  
  
  RESULTS
  The median podocyte count was 20.3 (0.0-98.1) for group GN, and 176.9 (109.1-490.6) for GP. The mean body mass index was 30.2 kg/m2 (SD=5.6), mean gestational age was 35.1 weeks (SD=2.5), median systolic blood pressure was 130.0 mmHg (100.0-160.0) and median diastolic blood pressure was 80.0 mmHg (60.0-110.0). There was no significant correlation between podocyturia and body mass index (p=0.305), gestational age (p=0.392), systolic blood pressure (p=0.540) or diastolic blood pressure (p=0.540).
  
  
  CONCLUSIONS
  In this study, there was no podocyturia pattern consistent with the presence of active renal disease, although some of the women studied (15.8%) exhibited a significant loss. We believe that it is premature to recommend the inclusion of the determination of podocyturia in routine prenatal clinical practice in chronically hypertensive pregnant women.
authors.affiliation: Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Fernanda Badiani
authors.initials: FB
authors.lastname: Roberto
authors.affiliation: Programa de Pós-graduação em Obstetrícia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Thaís Alquezar
authors.initials: TA
authors.lastname: Facca
authors.affiliation: Programa de Pós-graduação em Obstetrícia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Jussara Leiko
authors.initials: JL
authors.lastname: Sato
authors.affiliation: Programa de Pós-graduação em Nefrologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Amélia Rodrigues Pereira
authors.initials: AR
authors.lastname: Sabino
authors.affiliation: Setor de Glomerulopatias e Imunopatologia Renal, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Sonia Kiyomi
authors.initials: SK
authors.lastname: Nishida
authors.affiliation: Setor de Glomerulopatias e Imunopatologia Renal, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Gianna
authors.initials: G
authors.lastname: Mastroianni-Kirsztajn
authors.affiliation: Setor de Hipertensão Arterial e Nefropatias na Gestação, Departamento de Obstetrícia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
authors.forename: Nelson
authors.initials: N
authors.lastname: Sass
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000652:urine; D050199:Podocytes; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000652:urine; D011379:Prognosis; D051437:Renal Insufficiency / Q000209:etiology*; D014556:Urine / Q000166:cytology*; D055815:Young Adult