title: Models and mechanisms of vascular dementia.
abstract: Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease (AD) plaguing the elderly population. VaD is a progressive disease caused by reduced blood flow to the brain, and it affects cognitive abilities especially executive functioning. VaD is poorly understood and lacks suitable animal models, which constrain the progress on understanding the basis of the disease and developing treatments. This review article discusses VaD, its risk factors, induced cognitive disability, various animal (rodent) models of VaD, pathology, and mechanisms of VaD and treatment options.
authors.affiliation: Neurology, Henry Ford Hospital, Detroit, MI, USA; Physics, Oakland University, Rochester, MI, USA. Electronic address: pvenkat3@hfhs.org.
authors.forename: Poornima
authors.initials: P
authors.lastname: Venkat
authors.affiliation: Neurology, Henry Ford Hospital, Detroit, MI, USA; Physics, Oakland University, Rochester, MI, USA. Electronic address: mchopp1@hfhs.org.
authors.forename: Michael
authors.initials: M
authors.lastname: Chopp
authors.affiliation: Neurology, Henry Ford Hospital, Detroit, MI, USA; Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin Geriatrics Institute, Tianjin, China. Electronic address: jieli@neuro.hfh.edu.
authors.forename: Jieli
authors.initials: J
authors.lastname: Chen
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology; D000818:Animals; D003072:Cognition Disorders / Q000209:etiology*; D015140:Dementia, Vascular / Q000150:complications* / Q000209:etiology*; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D006973:Hypertension / Q000150:complications; D008659:Metabolic Diseases / Q000150:complications; D012307:Risk Factors
keywords: Cognition; High fat diet; Multiple infarct dementia; Treatment; Vascular dementia