title: Folic acid-conjugated TiO2-doped mesoporous carbonaceous nanocomposites loaded with Mitoxantrone HCl for chemo-photodynamic therapy.
abstract: Recently, porous carbons have showed great potential in many areas. In this study, TiO2-doped mesoporous carbonaceous (TiO2@C) nanoparticles were obtained by a simple one-pot hydrothermal treatment, folic acid (FA) was conjugated to TiO2@C through an amide bond, then Mitoxantrone HCl (MTX) was adsorbed onto TiO2@C-FA and a drug delivery system, TiO2@C-FA/MTX was obtained. TiO2@C-FA/MTX showed a much faster MTX release at pH 4.5 than at pH 6.0 and pH 7.4. Furthermore, compared with free MTX, this drug delivery system showed a dose-dependent cytotoxicity by varying the irradiance, and afforded higher antitumor efficacy in cultured PC3 cells in vitro. The ability of TiO2@C-FA/MTX to combine chemotherapy with photodynamic activity enhanced the cancer cell killing effect in vitro, demonstrating that TiO2@C-FA/MTX has a great potential for cancer therapy in the future.
authors.affiliation: School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, PR China. wyx040123@126.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Ya
authors.initials: Y
authors.lastname: Ou-Yang
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Yi-Qiu
authors.initials: YQ
authors.lastname: Wang
authors.forename: Xia-Li
authors.initials: XL
authors.lastname: Zhu
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Zhang
mesh_terms: D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D005492:Folic Acid / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008942:Mitoxantrone / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use*; D010778:Photochemotherapy / Q000379:methods*; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D014025:Titanium / Q000737:chemistry*
chemical_list: C009495:titanium dioxide; D005492:Folic Acid; D008942:Mitoxantrone; D014025:Titanium