title: Cardiovascular comorbidities in patients with rosacea: A nationwide case-control study from Taiwan.
abstract: BACKGROUND
  Rosacea is a chronic inflammatory skin disease. Inflammation plays a prominent role in atherosclerosis and its complications.
  
  
  OBJECTIVE
  We sought to investigate the associations of rosacea with cardiovascular disease risk factors and cardiovascular diseases from a nationwide population-based database.
  
  
  METHODS
  A total of 33,553 patients with rosacea and 67,106 age- and gender-matched control subjects were identified from the National Health Insurance Research Database in Taiwan from 1997 to 2010. Multivariate logistic regressions were performed to compare the odds of comorbidities between the 2 groups.
  
  
  RESULTS
  Dyslipidemia (odds ratio 1.41; 95% confidence interval 1.36-1.46), coronary artery disease (odds ratio 1.35, 95% confidence interval 1.29-1.41), and hypertension (odds ratio 1.17, 95% confidence interval 1.12-1.21) were significantly associated with rosacea. Coronary artery disease remained independently associated with rosacea after adjustment for hypertension, diabetes mellitus, and dyslipidemia. Male patients with rosacea had higher risks for all comorbidities than female patients with rosacea.
  
  
  CONCLUSIONS
  The National Health Insurance Research Database does not contain information regarding rosacea subtypes or disease severity, or laboratory data.
  
  
  CONCLUSIONS
  Patients with rosacea are more likely to have dyslipidemia and hypertension. They are also at increased risk of coronary artery disease after adjustment for cardiovascular disease risk factors.
authors.affiliation: Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan; Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Tuan-Chun
authors.initials: TC
authors.lastname: Hua
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Pei-I
authors.initials: PI
authors.lastname: Chung
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan.
authors.forename: Yi-Ju
authors.initials: YJ
authors.lastname: Chen
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan; Department of Dermatology, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Lung-Chi
authors.initials: LC
authors.lastname: Wu
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Yen-Da
authors.initials: YD
authors.lastname: Chen
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Chian-Yaw
authors.initials: CY
authors.lastname: Hwang
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Szu-Yin
authors.initials: SY
authors.lastname: Chu
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Chih-Chiang
authors.initials: CC
authors.lastname: Chen
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Ding-Dar
authors.initials: DD
authors.lastname: Lee
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address: ytchang@vghtpe.gov.tw.
authors.forename: Yun-Ting
authors.initials: YT
authors.lastname: Chang
authors.affiliation: Department of Dermatology, National Yang-Ming University, Taipei, Taiwan; Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Dermatology, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Han-Nan
authors.initials: HN
authors.lastname: Liu
mesh_terms: D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000453:epidemiology*; D016022:Case-Control Studies; D015897:Comorbidity; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology; D050171:Dyslipidemias / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D012393:Rosacea / Q000175:diagnosis* / Q000453:epidemiology*; D012720:Severity of Illness Index; D017678:Sex Distribution; D013624:Taiwan / Q000453:epidemiology
keywords: atherosclerosis; cardiovascular disease; coronary artery disease; dyslipidemia; inflammation; psoriasis; rosacea