title: Captopril in congenital chloride diarrhoea: a case study.
abstract: An 11 months 22 days old girl presented with a history of watery diarrhoea since birth, failure to thrive, and developmental delay. Her diagnosis was congenital chloride diarrhoea (CCD) with raised level of chloride (>90 mmol/L) in stool in the absence of cystic fibrosis. Management of CCD included replacement of NaCl, KCl, and correction of dehydration. Diarrhoea of the patient was resolved with Captopril, which was initially provided to the patient for managing heart failure. To our knowledge, this is the first reported case of CCD that shows the beneficial effect of Captopril. Therefore, we suggest that further study is warranted as to the potential for Captopril as additional option in the treatment for CCD. We present this case report with the informed consent of the patient's guardian.
authors.affiliation: icddr,b, GPO Box 128, Dhaka 1000, Bangladesh.
authors.forename: Shoeb
authors.initials: S
authors.lastname: Bin Islam
authors.affiliation: icddr,b, GPO Box 128, Dhaka 1000, Bangladesh.
authors.forename: Ramendra Nath
authors.initials: RN
authors.lastname: Mazumder
authors.affiliation: icddr,b, GPO Box 128, Dhaka 1000, Bangladesh.
authors.forename: Mohammod Jobayer
authors.initials: MJ
authors.lastname: Chisti
authors.affiliation: icddr,b, GPO Box 128, Dhaka 1000, Bangladesh.
authors.lastname: Sharifuzzaman
authors.affiliation: icddr,b, GPO Box 128, Dhaka 1000, Bangladesh.
authors.forename: Lubaba
authors.initials: L
authors.lastname: Sahreen
authors.affiliation: icddr,b, GPO Box 128, Dhaka 1000, Bangladesh.
authors.forename: Tahmeed
authors.initials: T
authors.lastname: Ahmed
authors.affiliation: icddr,b, GPO Box 128, Dhaka 1000, Bangladesh.
authors.forename: Nur
authors.initials: N
authors.lastname: Haque Alam
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use*; D003967:Diarrhea / Q000151:congenital* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007223:Infant; D008661:Metabolism, Inborn Errors / Q000188:drug therapy*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril