title: Approaches toward improving the prognosis of pediatric patients with glioma: pursuing mutant drug targets with emerging small molecules.
abstract: Gliomas represent approximately 70% of all pediatric brain tumors, and most of these are of astrocytic lineage; furthermore, malignant or high-grade astrocytomas account for approximately 20% of pediatric astrocytoma. Treatment options for pediatric patients with glioma are limited. Although low-grade astrocytomas are relatively slow-growing tumors that can often be cured through surgical resection, a significant proportion of cases recur, as such, new treatments are desperately needed. This review covers the various approaches that are currently being made toward improving the prognosis of pediatric patients with glioma by pursuing pediatric-selective mutant drug targets with emerging small molecules.
authors.affiliation: School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Lancashire, UK. Electronic address: TJSnape@uclan.ac.uk.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Snape
authors.affiliation: Brain Tumour Research Centre, University of Wolverhampton, Wolverhampton, UK.
authors.forename: Tracy
authors.initials: T
authors.lastname: Warr
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D005910:Glioma / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000187:drug effects / Q000235:genetics; D010372:Pediatrics; D011379:Prognosis; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors