title: Comparison between MDCT and Grayscale IVUS in a Quantitative Analysis of Coronary Lumen in Segments with or without Atherosclerotic Plaques.
abstract: BACKGROUND
  The diagnostic accuracy of 64-slice MDCT in comparison with IVUS has been poorly described and is mainly restricted to reports analyzing segments with documented atherosclerotic plaques.
  
  
  OBJECTIVE
  We compared 64-slice multidetector computed tomography (MDCT) with gray scale intravascular ultrasound (IVUS) for the evaluation of coronary lumen dimensions in the context of a comprehensive analysis, including segments with absent or mild disease.
  
  
  METHODS
  The 64-slice MDCT was performed within 72 h before the IVUS imaging, which was obtained for at least one coronary, regardless of the presence of luminal stenosis at angiography. A total of 21 patients were included, with 70 imaged vessels (total length 114.6 ± 38.3 mm per patient). A coronary plaque was diagnosed in segments with plaque burden > 40%.
  
  
  RESULTS
  At patient, vessel, and segment levels, average lumen area, minimal lumen area, and minimal lumen diameter were highly correlated between IVUS and 64-slice MDCT (p < 0.01). However, 64-slice MDCT tended to underestimate the lumen size with a relatively wide dispersion of the differences. The comparison between 64-slice MDCT and IVUS lumen measurements was not substantially affected by the presence or absence of an underlying plaque. In addition, 64-slice MDCT showed good global accuracy for the detection of IVUS parameters associated with flow-limiting lesions.
  
  
  CONCLUSIONS
  In a comprehensive, multi-territory, and whole-artery analysis, the assessment of coronary lumen by 64-slice MDCT compared with coronary IVUS showed a good overall diagnostic ability, regardless of the presence or absence of underlying atherosclerotic plaques.
authors.affiliation: Heart Institute, Medical School, University of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: João L A A
authors.initials: JL
authors.lastname: Falcão
authors.affiliation: Heart Institute, Medical School, University of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Breno A A
authors.initials: BA
authors.lastname: Falcão
authors.affiliation: Cedars-Sinai Heart Institute, Los Angeles, California, United States.
authors.forename: Swaminatha V
authors.initials: SV
authors.lastname: Gurudevan
authors.affiliation: Heart Institute, Medical School, University of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Campos
authors.affiliation: Heart Institute, Medical School, University of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Expedito R
authors.initials: ER
authors.lastname: Silva
authors.affiliation: Heart Institute, Medical School, University of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Kalil-Filho
authors.affiliation: Heart Institute, Medical School, University of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Rochitte
authors.affiliation: Heart Institute, Medical School, University of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Afonso A
authors.initials: AA
authors.lastname: Shiozaki
authors.affiliation: Heart Institute, Medical School, University of São Paulo Medical School, São Paulo, SP, Brazil.
authors.forename: Otavio R
authors.initials: OR
authors.lastname: Coelho-Filho
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Lemos
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D019160:Endosonography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging*