title: Solid Pseudopapillary Neoplasms of the Pancreas: a 19-Year Multicenter Experience in China.
abstract: OBJECTIVE
  The aim of this study was to determine the clinicopathological features, surgical management, and prognosis of solid pseudopapillary neoplasms (SPNs) of the pancreas.
  
  
  METHODS
  This study conducted a retrospective analysis of 97 patients who underwent surgery for a pathologically confirmed SPN in five hospitals between January 1996 and December 2014.
  
  
  RESULTS
  The 97 cases included 93 female and 4 male patients, and the average age was 31.2 years. The tumor was located in the body or tail (70.1%), the head (20.6%), and the neck (9.3%). All patients underwent surgical exploration, including distal pancreatectomy (63.9%), pancreaticoduodenectomy (20.6%) (partial portal vein or superior mesenteric vein resection and artificial vascular graft reconstruction performed in 4.1% of the patients), central pancreatectomy (10.3%), enucleation (5.2%), and liver resection (1.0%). 16.5% of the patients had malignant tumors. The positive rate of Ki-67 was 66.7% in patients diagnosed with a malignant neoplasm and was comparable to 8.4% of the patients diagnosed to have a benign neoplasm (p < 0.001). After a median follow-up of 70.1 months, three patients had recurrence and one patient died of liver metastasis.
  
  
  CONCLUSIONS
  SPN is a rare neoplasm with low malignant potential. Surgical resection is warranted even in the presence of local invasion or metastases as patients demonstrate excellent long-term survival. Positive immunoreactivity for Ki-67 may predict the malignant potential and poor outcome of SPNs.
authors.affiliation: Department of Abdominal Surgery, Zhejiang Cancer Hospital, 38# Guangji Road, Hangzhou, 310022, China, yupengfei23@163.com.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Yu
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Cheng
authors.forename: Yian
authors.initials: Y
authors.lastname: Du
authors.forename: Litao
authors.initials: L
authors.lastname: Yang
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Xu
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Yin
authors.forename: Zhengxiang
authors.initials: Z
authors.lastname: Zhong
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Wang
authors.forename: Hongbao
authors.initials: H
authors.lastname: Xu
authors.forename: Conggang
authors.initials: C
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China; D005260:Female; D006498:Hepatectomy / Q000706:statistics & numerical data; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010180:Pancreatectomy / Q000379:methods / Q000706:statistics & numerical data; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000706:statistics & numerical data; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019394:Ki-67 Antigen