title: Local sympathetic stimulation not only have local effects in patients with Raynaud's phenomenon.
abstract: OBJECTIVE
  Many other organs and system can be affected in the course of Primary Raynaud's Phenomenon (RP). Simultaneously increased vasospasm in the pulmonary vascular bed may likely affect the pulmonary function. Therefore, we investigated the effect of Raynaud's phenomenon on the respiratory functions in this study.
  
  
  METHODS
  Between March 2014 and December 2014, 30 patients with the diagnosis of PRP more than two years and 32 age-sex matched healthy controls were enrolled into this study. Cold stimulation test (CST) was performed. Pulmonary function test were performed following 30 minutes after CST and spirometric measurements were calculated.
  
  
  RESULTS
  There were no statistically significant differences between two groups regarding their demographic and clinical data. Mean duration of symptoms from onset to present was 3.01 ± 1.05 years. Patients with Primary RP had significantly lower FVC and higher FEV1/FVC values compared to the control groups (p = 0.015 and p=0.045, respectively).
  
  
  CONCLUSIONS
  We found that statistically significant decrease of FVC values in patients with Primary RP compared to the healthy controls could be a impaired innervation of pulmonary system and a predictor of pulmonary vasospasm and/or pulmonary Raynaud's phenomenon, which may develop in future periods.
authors.affiliation: Department of Cardiovascular Surgery, Gulhane Military Academy of Medicine, Ankara, Turkey. kubilaykarabacak@yahoo.com.
authors.forename: K
authors.initials: K
authors.lastname: Karabacak
authors.forename: D
authors.initials: D
authors.lastname: Dogan
authors.forename: M
authors.initials: M
authors.lastname: Celik
authors.forename: E
authors.initials: E
authors.lastname: Kaya
authors.forename: M
authors.initials: M
authors.lastname: Kadan
authors.forename: H
authors.initials: H
authors.lastname: Isik
authors.forename: N
authors.initials: N
authors.lastname: Ocal
authors.forename: S
authors.initials: S
authors.lastname: Doganci
authors.forename: V
authors.initials: V
authors.lastname: Yildirim
authors.forename: U
authors.initials: U
authors.lastname: Demirkilic
mesh_terms: D016022:Case-Control Studies; D003080:Cold Temperature; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011652:Pulmonary Circulation; D011928:Raynaud Disease / Q000503:physiopathology*; D013147:Spirometry; D055815:Young Adult