title: Maternal serum copeptin, MR-proANP and procalcitonin levels at 11-13 weeks gestation in the prediction of preeclampsia.
abstract: OBJECTIVE
  We investigated the potential value of maternal serum copeptin, midregional proatrial natriuretic peptide (MR-proANP) and Procalcitonin (PCT) levels at 11-13 weeks' gestation in the prediction of preeclampsia (PE) in a case-control study.
  
  
  METHODS
  Maternal serum concentration of copeptin, MR-proANP and PCT were measured at 11-13 weeks' gestation in cases of PE (n = 35) and controls (n = 100). The PE group was divided into early-onset PE (EO-PE) and late-onset PE (LO-PE). From the regression model, the value in each case and control was expressed as a multiple of the expected median (MoM). The Mann-Whitney test was used to determine the significance of differences in the median MoM in each outcome group from that in the controls.
  
  
  RESULTS
  In the PE group, compared to controls, maternal serum concentrations of copeptin, MR-proANP and PCT were not significantly different.
  
  
  CONCLUSIONS
  The maternal serum copeptin, MR-proANP and PCT levels are higher in EO-PE and LO-PE patients, but the difference is not significant. Thus, their levels in first trimester are not proven to be effective markers to screen for PE.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Essen, Hufelandstr. 55, 45147, Essen, Germany. cahit.birdir@uk-essen.de.
authors.forename: Cahit
authors.initials: C
authors.lastname: Birdir
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Essen, Hufelandstr. 55, 45147, Essen, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Janssen
authors.affiliation: Bucur Maternity, Saint John Clinical Emergency Hospital, University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Anca Daniela
authors.initials: AD
authors.lastname: Stanescu
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Essen, Hufelandstr. 55, 45147, Essen, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Enekwe
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Essen, Hufelandstr. 55, 45147, Essen, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Kasimir-Bauer
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Essen, Hufelandstr. 55, 45147, Essen, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gellhaus
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Essen, Hufelandstr. 55, 45147, Essen, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Kimmig
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Essen, Hufelandstr. 55, 45147, Essen, Germany.
authors.forename: Angela
authors.initials: A
authors.lastname: Köninger
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood* / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006020:Glycopeptides / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011498:Protein Precursors / Q000097:blood* / Q000378:metabolism
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D006020:Glycopeptides; D011498:Protein Precursors; C048197:copeptins; C552580:midregional pro-atrial natriuretic peptide, human; D009320:Atrial Natriuretic Factor; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide
keywords: Copeptin; MR-proANP; PCT; Preeclampsia; Procalcitonin