title: α-Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier.
abstract: Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.
authors.forename: Inbal
authors.initials: I
authors.lastname: Lapidot
authors.forename: Danny
authors.initials: D
authors.lastname: Baranes
authors.forename: Albert
authors.initials: A
authors.lastname: Pinhasov
authors.forename: Gary
authors.initials: G
authors.lastname: Gellerman
authors.forename: Amnon
authors.initials: A
authors.lastname: Albeck
authors.affiliation: Department of Biological Chemistry, Ariel University, Ariel 40700, Israel. flaviog@ariel.ac.il.
authors.forename: Flavio
authors.initials: F
authors.lastname: Grynszpan
authors.affiliation: Department of Biological Chemistry, Ariel University, Ariel 40700, Israel. shimon120@gmail.com.
authors.forename: Shimon E
authors.initials: SE
authors.lastname: Shatzmiller
mesh_terms: D000621:Aminoisobutyric Acids / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D000818:Animals; D053961:Azabicyclo Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D001812:Blood-Brain Barrier / Q000378:metabolism*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008856:Microscopy, Fluorescence; D014018:Tissue Distribution
chemical_list: D000621:Aminoisobutyric Acids; D053961:Azabicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005456:Fluorescent Dyes; C021149:bimanes