title: The Nlrp3 inflammasome admits defeat.
abstract: The Nlrp3 inflammasome triggers interleukin-1 secretion by myeloid cells in response to endogenous and exogenous danger signals. Two recent studies identified the sulfonylurea MCC950 and the ketone metabolite β-hydroxybutyrate as specific inhibitors of the Nlrp3 inflammasome, with promising therapeutic potential for the treatment of auto-inflammatory diseases.
authors.affiliation: Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
authors.forename: Christina J
authors.initials: CJ
authors.lastname: Groß
authors.affiliation: Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany. Electronic address: olaf.gross@tum.de.
authors.forename: Olaf
authors.initials: O
authors.lastname: Groß
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000494:pharmacology*; D000818:Animals; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D020170:Caspase 1 / Q000187:drug effects*; D056587:Cryopyrin-Associated Periodic Syndromes / Q000188:drug therapy*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy*; D005260:Female; D006576:Heterocyclic Compounds, 4 or More Rings / Q000627:therapeutic use*; D006801:Humans; D058847:Inflammasomes / Q000037:antagonists & inhibitors*; D053583:Interleukin-1beta / Q000187:drug effects*; D008297:Male; D009000:Monocytes / Q000187:drug effects*; D009103:Multiple Sclerosis; D013450:Sulfones / Q000627:therapeutic use*
chemical_list: D002352:Carrier Proteins; D006576:Heterocyclic Compounds, 4 or More Rings; D058847:Inflammasomes; D053583:Interleukin-1beta; D013450:Sulfones; D020170:Caspase 1; D020155:3-Hydroxybutyric Acid