title: Corrosion resistance of Ti modified by chitosan-gold nanoparticles for orthopedic implantation.
abstract: Highly uniform bionanocomposite film composed of chitosan (CS) and gold nanoparticles (AuNPs) was synthesized successfully by electrodeposition method. The influence of AuNPs/CS bionanocomposite film on corrosion resistance of Ti was investigated. Surface morphology and compositional properties of the bionanocomposite were analyzed by scanning electron microscope (SEM), energy dispersive X-ray analysis (EDX), and X-ray photoelectron spectroscopy (XPS). Moreover, cyclic voltammetry (CV), open-circuit potential measurements (OCP), electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (Rp) were used to examine the corrosion behavior in Hanks' solution. In comparison with Ti, Nyquist and Bode plots displayed higher impedance values and phase angles for AuNPs/CS biocomposite denoting a more protective passive film on Ti with inhibition efficiency (IE%) of 98%. An electric equivalent circuit with three time constants was modeled for the bionanocomposite. In addition, the antibacterial effect revealed the high efficiencies of the bionanocomposite film for inhibiting bacterial growth. The combination of the high biocompatibility of chitosan and strong adsorption ability of AuNPs make AuNPs/CS bionanocomposite promising candidate for modifying biomaterial surfaces for medical implantation applications.
authors.affiliation: Taif University, Faculty of Science, Chemistry Department, Hawiya 888, Taif, Saudi Arabia; Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
authors.forename: R A
authors.initials: RA
authors.lastname: Farghali
authors.affiliation: Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
authors.forename: A M
authors.initials: AM
authors.lastname: Fekry
authors.affiliation: Taif University, Faculty of Science, Chemistry Department, Hawiya 888, Taif, Saudi Arabia; Forensic Chemistry Laboratories, Medico Legal Department, Ministry of Justice, Cairo, Egypt. Electronic address: rashaauf@yahoo.com.
authors.forename: Rasha A
authors.initials: RA
authors.lastname: Ahmed
authors.affiliation: Biochemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
authors.forename: H K A
authors.initials: HK
authors.lastname: Elhakim
mesh_terms: D000327:Adsorption; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D020099:Coated Materials, Biocompatible; D003343:Corrosion; D055664:Electrochemical Techniques; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D019736:Prostheses and Implants; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D006046:Gold; D048271:Chitosan; D014025:Titanium
keywords: AuNPs; Chitosan; Titanium