title: Lack of protection against ebola virus from chloroquine in mice and hamsters.
abstract: The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.
authors.forename: Darryl
authors.initials: D
authors.lastname: Falzarano
authors.forename: David
authors.initials: D
authors.lastname: Safronetz
authors.forename: Joseph
authors.initials: J
authors.lastname: Prescott
authors.forename: Andrea
authors.initials: A
authors.lastname: Marzi
authors.forename: Friederike
authors.initials: F
authors.lastname: Feldmann
authors.forename: Heinz
authors.initials: H
authors.lastname: Feldmann
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002460:Cell Line; D002738:Chloroquine / Q000008:administration & dosage / Q000494:pharmacology*; D006224:Cricetinae; D004195:Disease Models, Animal; D029043:Ebolavirus / Q000187:drug effects*; D019142:Hemorrhagic Fever, Ebola / Q000662:veterinary*; D051379:Mice; D019562:Viral Load; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D002738:Chloroquine
keywords: Ebola virus infection; animal model; antimicrobial drugs; antiviral drug; chloroquine; treatment; viruses