title: Human granulocytic anaplasmosis.
abstract: Human granulocytic anaplasmosis, a deer tick-transmitted rickettsial infection caused by Anaplasma phagocytophilum, is a common cause of undifferentiated fever in the northeast and upper Midwest United States. Patients are often initially diagnosed with a mild viral infection, and illness readily resolves in most cases. However, as many as 3% develop life-threatening complications and nearly 1% die from the infection. Although coinfections with Borrelia burgdorferi and Babesia microti occur, there is little evidence to suggest synergism of disease or a role for A phagocytophilum in chronic illness. No vaccine is available.
authors.affiliation: Department of Family Medicine, University of Minnesota School of Medicine, Duluth, MN, USA; St. Luke's Infectious Disease Associates, 1001 East Superior Street, Suite L201, Duluth, MN 55802, USA.
authors.forename: Johan S
authors.initials: JS
authors.lastname: Bakken
authors.affiliation: Department of Pathology, University of Maryland School of Medicine, 685 West Baltimore Street, HSF1 322D, Baltimore, MD 21201, USA; Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: sdumler@som.umaryland.edu.
authors.forename: J Stephen
authors.initials: JS
authors.lastname: Dumler
mesh_terms: D041081:Anaplasma phagocytophilum / Q000302:isolation & purification*; D000712:Anaplasmosis / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control; D005334:Fever / Q000382:microbiology; D006098:Granulocytes / Q000382:microbiology*; D006801:Humans; D012307:Risk Factors
keywords: Anaplasmosis; Diagnosis; Granulocytic; Human; Management