title: A CAD System for the Acquisition and Classification of Breast TMA in Pathology.
abstract: Breast cancer is the most common type of cancer and the fifth leading cause of death in women over 40. Therefore, prompt diagnostic and treatment is essential. In this work a TMA Computer Aided Diagnosis (CAD) system has been implemented to provide support to pathologists in their daily work. For that purpose, the tool covers each and every process from the TMA core image acquisition to their individual classification. The first process includes: tissue core location, segmentation and rigid registration of digital microscopic images acquired at different magnifications (5x, 10x, 20x, 20x and 40x) from different devices. The classification process allows performing the core classification selecting different types of color models, texture descriptors and classifiers. Finally, the cores are classified into three categories: malignant, doubtful and benign.
authors.affiliation: VISILAB, Universidad de Castilla-La Mancha, Spain.
authors.forename: M Milagro
authors.initials: MM
authors.lastname: Fernández-Carrobles
authors.affiliation: VISILAB, Universidad de Castilla-La Mancha, Spain.
authors.forename: Gloria
authors.initials: G
authors.lastname: Bueno
authors.affiliation: VISILAB, Universidad de Castilla-La Mancha, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Déniz
authors.affiliation: VISILAB, Universidad de Castilla-La Mancha, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Salido
authors.affiliation: Department of Pathology, Hospital de Jerez de la Frontera, Spain.
authors.forename: Marcial
authors.initials: M
authors.lastname: García-Rojo
authors.affiliation: Department of Pathology, Hospital General Universitario de Ciudad Real, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: González-López
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008853:Microscopy / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013030:Spain; D060388:Support Vector Machine; D046888:Tissue Array Analysis / Q000379:methods*