title: PPARδ signaling regulates colorectal cancer.
abstract: Peroxisome proliferator-activated receptorδ (PPARδ) belongs to the PPARs receptor family including PPARα, PPARδ, and PPARγ. PPARδ is a ligand-activated transcription factor that plays a critical role in regulating cancer progression. PPARδ-linked tumorigenesis was first identified in colorectal cancer, which is demonstrated by the following evidences, so PPARε is a potential drug target for colorectal cancer. In contrast, some observations show that PPARδ negatively regulates colorectal cancer event. In the present review, the recent progress of PPARδ signaling-mediated colorectal cancer is covered.
authors.forename: Mengli
authors.initials: M
authors.lastname: You
authors.forename: Shuping
authors.initials: S
authors.lastname: Yuan
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Shi
authors.affiliation: Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu Province, 212013, China. houyz@ujs.edu.cn.
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Hou
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D047494:PPAR delta / Q000187:drug effects / Q000235:genetics*; D047495:PPAR gamma; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics; D051176:beta Catenin / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D047494:PPAR delta; D047495:PPAR gamma; D042461:Vascular Endothelial Growth Factor A; D051176:beta Catenin