title: Chemotherapy and target therapy as neo-adjuvant approach for initially unresectable colorectal liver metastases.
abstract: Although surgery is the most effective treatment for liver metastases in colorectal cancer patients, only 15-20% of these patients are suitable for a radical surgical approach, and metastases recurrence may occur at follow up. In the last decade, the use of pre-operative chemotherapy in combination with new biological drugs has been introduced. We reviewed data of neo-adjuvant chemotherapy strategies aimed at increasing the resection rate of liver metastases in colorectal cancer patients who were initially considered unresectable.
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina - "Sapienza" University of Rome, Italy;
authors.forename: Luigi
authors.initials: L
authors.lastname: Rossi
authors.affiliation: Gastroenterology and Digestive Endoscopy; Nuovo Regina Margherita Hospital, Rome, Italy;
authors.forename: Angelo
authors.initials: A
authors.lastname: Zullo
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina - "Sapienza" University of Rome, Italy;
authors.forename: Federica
authors.initials: F
authors.lastname: Zoratto
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina - "Sapienza" University of Rome, Italy;
authors.forename: Anselmo
authors.initials: A
authors.lastname: Papa
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina - "Sapienza" University of Rome, Italy;
authors.forename: Martina
authors.initials: M
authors.lastname: Strudel
authors.affiliation: Oncology Unit Di Liegro Hospital, Gaeta, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Colonna
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, Oncology Unit, S.M. Goretti Hospital, Latina - "Sapienza" University of Rome, Italy;
authors.forename: Silverio
authors.initials: S
authors.lastname: Tomao
keywords: bevacizumab; biological therapy; cetuximab.; chemotherapy; colorectal cancer; liver metastasis; neo-adjuvant chemotherapy