title: Bioprinting scale-up tissue and organ constructs for transplantation.
abstract: Bioprinting is an emerging field that is having a revolutionary impact on the medical sciences. It offers great precision for the spatial placement of cells, proteins, genes, drugs, and biologically active particles to better guide tissue generation and formation. This emerging biotechnology appears to be promising for advancing tissue engineering toward functional tissue and organ fabrication for transplantation, drug testing, research investigations, and cancer or disease modeling, and has recently attracted growing interest worldwide among researchers and the general public. In this Opinion, I highlight possibilities for the bioprinting scale-up of functional tissue and organ constructs for transplantation and provide the reader with alternative approaches, their limitations, and promising directions for new research prospects.
authors.affiliation: Biomanufacturing Laboratory, The University of Iowa, Iowa City, IA, 52242, USA. Electronic address: Ibrahim-ozbolat@uiowa.edu.
authors.forename: Ibrahim T
authors.initials: IT
authors.lastname: Ozbolat
mesh_terms: D000818:Animals; D062028:Bioprinting; D002478:Cells, Cultured; D004867:Equipment Design; D006801:Humans; D051379:Mice; D023822:Tissue Engineering; D019737:Transplants
keywords: bioprinting; bioprinting for transplantation; in situ bioprinting; vascularized-tissue printing