title: [A case of Paclitaxel-induced peripheral neuropathy successfully treated with duloxetine].
abstract: Here, we report about a 60-year-old woman with metastatic breast cancer who was successfully treated for paclitaxelinduced peripheral neuropathy with duloxetine. She was administered trastuzumab plus paclitaxel(PTX)combination therapy that was ultimately discontinued because of grade 3 peripheral neuropathy detected on day 15, according to the CTCAE (v4.0). She was administered duloxetine on day 90 after the end of the previous therapy because of the peripheral neuropathy. Thereafter, the peripheral neuropathy decreased to grade 1, which enabled PTX administration on her request. Further trials are required to confirm the efficacy of duloxetine.
authors.affiliation: Dept. of Pharmacy, National Hospital Organization Kure Medical Center and Chugoku Cancer Center.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nagashima
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Kiba
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Takuya
authors.initials: T
authors.lastname: Mura
authors.forename: Sayoko
authors.initials: S
authors.lastname: Kajiume
authors.forename: Yuuko
authors.initials: Y
authors.lastname: Okada
authors.forename: Nao
authors.initials: N
authors.lastname: Morii
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ichiba
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Yamashiro
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000068736:Duloxetine Hydrochloride; D005260:Female; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy*; D013876:Thiophenes / Q000627:therapeutic use*; D000068878:Trastuzumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D013876:Thiophenes; D000068736:Duloxetine Hydrochloride; D000068878:Trastuzumab; D017239:Paclitaxel