title: Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain.
abstract: In this study, we examined the effect of orally administrated dipeptides containing Tyr (Y) on the metabolism of catecholamines in mouse brains. We found that among eight synthetic dipeptides whose sequences are present frequently in soy proteins, Ser-Tyr (SY), Ile-Tyr, and Tyr-Pro had the highest apparent permeability coefficients in monolayers of human intestinal epithelial Caco-2 cells. When administrated orally, SY markedly increased tyrosine content in the cerebral cortex compared to the vehicle control, Ile-Tyr, Tyr-Pro, and Y alone. The oral administration of SY more effectively increased 3-methoxy-4-hydroxyphenylethyleneglycol, the principal metabolite of noradrenaline, in the cerebral cortex and hippocampus than did Ile-Tyr, Tyr-Pro, or Y alone. Central noradrenergic turnover was also markedly stimulated by SY administration. These in vivo observations strongly suggest that SY is more potent in boosting central catecholamine transmission, particularly the noradrenergic system, than Y alone or other dipeptides that include Y.
authors.affiliation: a Laboratory of Functional Genomics and Metabolism, Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences , Kyushu University , Fukuoka , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichinose
authors.forename: Kazuki
authors.initials: K
authors.lastname: Moriyasu
authors.forename: Akane
authors.initials: A
authors.lastname: Nakahata
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Toshiro
authors.initials: T
authors.lastname: Matsui
authors.forename: Shigeki
authors.initials: S
authors.lastname: Furuya
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018938:Caco-2 Cells; D002395:Catecholamines / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D004151:Dipeptides / Q000008:administration & dosage; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism; D014443:Tyrosine / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D002395:Catecholamines; D004151:Dipeptides; C493687:isoleucyl-tyrosine; C120594:tyrosyl-proline; D014443:Tyrosine; D008734:Methoxyhydroxyphenylglycol; D009638:Norepinephrine
keywords: brain; dipeptide; noradrenaline; soy; tyrosine