title: Alterations in white matter integrity in first-episode, treatment-naive patients with somatization disorder.
abstract: White matter (WM) abnormality in somatization disorder (SD) has not been reported yet. This study was designed to elucidate the alterations in WM integrity in SD. A total of 25 patients with SD and 28 healthy controls were enrolled in the study. WM integrity was analyzed using tract-based spatial statistics. No differences were found between the patients and the controls for fractional anisotropy (FA) values, mean diffusivity (MD), axial diffusivity, and radial diffusivity values at the corrected p<0.05 level. Patients with SD had significantly decreased FA values in the cingulum and inferior fronto-occipital fasciculus, and significantly increased MD values in the anterior thalamic radiation and corticospinal tract compared with the controls at the uncorrected p<0.005 level. Somatization severity was correlated with the FA values of the cingulum and inferior fronto-occipital fasciculus in the patients. The patients exhibit suggestive alterations in WM integrity in the cingulum, inferior fronto-occipital fasciculus, anterior thalamic radiation, and corticospinal tract.
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University,Guangxi, Nanning 530021, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China.
authors.forename: Muliang
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University,Guangxi, Nanning 530021, China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Yao
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Guangxi, Nanning 530021, China.
authors.forename: Liling
authors.initials: L
authors.lastname: Long
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University,Guangxi, Nanning 530021, China.
authors.forename: Miaoyu
authors.initials: M
authors.lastname: Yu
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University,Guangxi, Nanning 530021, China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University,Guangxi, Nanning 530021, China.
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University,Guangxi, Nanning 530021, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University,Guangxi, Nanning 530021, China. Electronic address: guowenbin76@163.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013001:Somatoform Disorders / Q000473:pathology*; D066127:White Matter / Q000473:pathology*; D055815:Young Adult
keywords: Diffusion tensor imaging; Somatization disorder; Tract-based spatial statistics; White matter