title: Inflammation fuels tumor progress and metastasis.
abstract: Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Liu
authors.forename: Pengnian Charles
authors.initials: PC
authors.lastname: Lin
authors.affiliation: Department of Molecular and Cellular Biochemistry, 741 South Limestone Street, Lexington, KY 40536. peter.zhou@uky.edu.
authors.forename: Binhua P
authors.initials: BP
authors.lastname: Zhou
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D000860:Hypoxia / Q000473:pathology; D007249:Inflammation / Q000150:complications* / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000473:pathology*; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology*