title: Association of a neurokinin 3 receptor polymorphism with the anterior basal forebrain.
abstract: The neuropeptide neurokinin 3 (NK3) and its receptor modulate cholinergic activity of the basal forebrain (BF) and are implicated in learning and memory. In Alzheimer's disease, the rs2765 single-nucleotide polymorphism (SNP) of the NK3 receptor-coding gene TACR3 was correlated with the right hippocampus volume. Here, we studied the association of the rs2765 SNP with magnetic resonance imaging-based volumes of the BF and hippocampus in a population-based sample of 1967 participants between 21 and 90 years of age. The rs2765 SNP was significantly associated with the most anterior BF volume corresponding to the medial septum/diagonal band, and with a significantly steeper age-related volume decline. The rs2765 SNP was not associated with other BF subvolumes or hippocampus volumes. Apolipoprotein E ε4 showed no correlation with any brain volume or global cognition. Our findings in a large population-based sample suggest an association of an NK3 receptor SNP with age-related decline of rostral cholinergic BF volume.
authors.affiliation: Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany; DZNE, German Center for Neurodegenerative Diseases, Rostock/Greifswald, Rostock, Germany. Electronic address: stefan.teipel@med.uni-rostock.de.
authors.forename: Stefan J
authors.initials: SJ
authors.lastname: Teipel
authors.affiliation: DZNE, German Center for Neurodegenerative Diseases, Rostock/Greifswald, Rostock, Germany.
authors.forename: Michel J
authors.initials: MJ
authors.lastname: Grothe
authors.affiliation: DZNE, German Center for Neurodegenerative Diseases, Rostock/Greifswald, Greifswald, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Wittfeld
authors.affiliation: DZNE, German Center for Neurodegenerative Diseases, Rostock/Greifswald, Greifswald, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hoffmann
authors.affiliation: Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Hegenscheid
authors.affiliation: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
authors.forename: Henry
authors.initials: H
authors.lastname: Völzke
authors.affiliation: Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University, Greifswald, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Homuth
authors.affiliation: Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; Department of Psychiatry and Psychotherapy, HELIOS-Hospital Stralsund, Stralsund, Germany.
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Grabe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics / Q000473:pathology; D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology / Q000523:psychology; D066187:Basal Forebrain / Q000473:pathology*; D059329:Cholinergic Neurons / Q000502:physiology; D003071:Cognition / Q000502:physiology; D005260:Female; D056726:Genetic Association Studies; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007858:Learning / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009929:Organ Size / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018042:Receptors, Neurokinin-3 / Q000235:genetics*; D055815:Young Adult
chemical_list: D018042:Receptors, Neurokinin-3; C000601381:TACR3 protein, human
keywords: Brain structure; Cholinergic basal forebrain; Cognitive function; Genetics; Hippocampus; Imaging