title: Using EHRs for Heart Failure Therapy Recommendation Using Multidimensional Patient Similarity Analytics.
abstract: Electronic Health Records (EHRs) contain a wealth of information about an individual patient's diagnosis, treatment and health outcomes. This information can be leveraged effectively to identify patients who are similar to each for disease diagnosis and prognosis. In recent years, several machine learning methods have been proposed to assessing patient similarity, although the techniques have primarily focused on the use of patient diagnoses data from EHRs for the learning task. In this study, we develop a multidimensional patient similarity assessment technique that leverages multiple types of information from the EHR and predicts a medication plan for each new patient based on prior knowledge and data from similar patients. In our algorithm, patients have been clustered into different groups using a hierarchical clustering approach and subsequently have been assigned a medication plan based on the similarity index to the overall patient population. We evaluated the performance of our approach on a cohort of heart failure patients (N=1386) identified from EHR data at Mayo Clinic and achieved an AUC of 0.74. Our results suggest that it is feasible to harness population-based information from EHRs for an individual patient-specific assessment.
authors.affiliation: Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Maryam
authors.initials: M
authors.lastname: Panahiazar
authors.affiliation: Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Vahid
authors.initials: V
authors.lastname: Taslimitehrani
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
authors.forename: Naveen L
authors.initials: NL
authors.lastname: Pereira
authors.affiliation: Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN, USA.
authors.forename: Jyotishman
authors.initials: J
authors.lastname: Pathak
mesh_terms: D000066491:Clinical Decision-Making / Q000379:methods; D057225:Data Mining / Q000379:methods*; D020000:Decision Support Systems, Clinical / Q000458:organization & administration*; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D057286:Electronic Health Records / Q000458:organization & administration*; D006333:Heart Failure / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D000069550:Machine Learning; D010363:Pattern Recognition, Automated / Q000379:methods; D013813:Therapy, Computer-Assisted / Q000379:methods*