title: Elevated Serum Angiopoietin-like Protein 2 in Patients with Acute Coronary Syndrome.
abstract: OBJECTIVE
  Angiopoietin-like protein 2 (Angptl2) is regarded as a proinflammatory factor in the pathogenesis of atherosclerosis and is expressed at high levels in patients with coronary artery disease. However, direct evidence of Angptl2 in acute coronary syndrome (ACS) is lacking. Our study was designed to investigate a possible relationship between serum Angptl2 and ACS.
  
  
  METHODS
  We evaluated 251 consecutive patients undergoing coronary angiography, consisting of 132 patients with ACS (unstable angina pectoris n = 60, acute myocardial infarction n = 72), 50 patients with stable angina pectoris, and 69 control patients. Serum Angptl2 concentration was measured in peripheral venous blood by an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum Angptl2 levels were significant higher in patients with ACS than in those with stable angina (p <0.05) or controls (p <0.001). The difference between angplt2 levels in unstable angina and acute myocardial infarction subgroups was statistically insignificant (p = 0.831). In multivariable logistic regression models, using quartiles of Angptl2, Angptl2 was closely associated with ACS following adjustment of age, gender, established risk factors and high sensitivity C-reactive protein levels (odds ratio for quartile 4 vs. quartile 1: 10.182, 95% confidence interval 2.440-42.485, p = 0.001).
  
  
  CONCLUSIONS
  Serum Angptl2 is a new candidate biomarker for risk stratification of ACS.
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Yan Chai College, Wenzhou Medical College, Wenzhou, China.
authors.forename: Haotian
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Xueping
authors.initials: X
authors.lastname: Lin
authors.affiliation: Center of Medical Laboratory, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Bao
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Xianliang
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.
authors.forename: Mingfang
authors.initials: M
authors.lastname: Huang
authors.affiliation: Department of Cardiology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China. Electronic address: mdlzrong@126.com.
authors.forename: Zhurong
authors.initials: Z
authors.lastname: Luo
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis; D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000175:diagnosis; D000091302:Angiopoietin-Like Protein 2; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D017023:Coronary Angiography; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis; D018570:Risk Assessment
chemical_list: C485792:ANGPTL2 protein, human; D000091302:Angiopoietin-Like Protein 2; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; D015415:Biomarkers
keywords: Acute coronary syndrome; Angiopoietin-like protein 2; Atherosclerosis; Inflammation; Vulnerable plaque