title: Association between hepcidin, haemoglobin level and iron status in stage 4 chronic kidney disease patients with anaemia.
abstract: OBJECTIVE
  To explore the probable association of serum hepcidin and haemoglobin levels with iron and inflammation statuses in patients of chronic kidney disease stage 4 with anaemia.
  
  
  METHODS
  The cross-sectional study was conducted at Tabriz University of Medical Sciences, Iran, from March 2011 to October 2012, and comprised patients of chronic kidney disease stage 4 with anaemia. Serum biochemical factors as well as hepcidin, ferritin, interleukin 6, high sensitivity C-reactive protein and iron levels were measured using standard methods. Statistical correlations were established using regression analysis and Pearson's correlation coefficient.
  
  
  RESULTS
  There were 40 patients among whom 15(37.5%) were males and 25(62.5%) were females with an overall mean age of 55.68±14.4 years. There was a significant inverse relationship between hepcidin and haemoglobin levels (p<0.05). There were significant correlations between hepcidin with iron status, nutritional and inflammatory markers such as ferritin, Total iron binding capacity, albumin and interleukin 6 (p<0.05 each).
  
  
  CONCLUSIONS
  Hepcidin had negative correlation with haemoglobin level in stage 4 chronic kidney disease patients with adequate iron stores, which could be effective in the development of anaemia in such patients.
authors.affiliation: Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Reza Alipanah
authors.initials: RA
authors.lastname: Mogadam
authors.affiliation: Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Nemati
authors.affiliation: Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Firouz
authors.initials: F
authors.lastname: Amani
authors.affiliation: Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Ghorbanihaghjo
authors.affiliation: Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Argani
authors.affiliation: Department of Dialysis, Ardabil University of Medical Sciences, Ardabil, Iran.
authors.forename: Bahman
authors.initials: B
authors.lastname: Bashardoust
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood / Q000209:etiology; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D005260:Female; D005293:Ferritins / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D064451:Hepcidins / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007492:Iran; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D062072:Patient Acuity; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D064451:Hepcidins; D015850:Interleukin-6; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron
keywords: CKD, Hepcidin, Iron status, Anaemia.