title: A Method of Effectively Improved α-Mangostin Bioavailability.
abstract: α-Mangostin, a major xanthone isolated from the pericarp of Garcinia mangostana, exhibits anti-inflammatory and antitumor effects. Its absolute bioavailability is low, with minimal oral absorption. In this article, a soft capsule, with vegetable oil as the dispersion matrix, was prepared to improve the bioavailability of α-mangostin. Its pharmacokinetics and tissue distribution were determined in rats. An HPLC assay was established to determine the concentration of α-mangostin in biological samples. The validated method was used successfully to support pharmacokinetic and tissue distribution studies of α-mangostin in rats after intravenous (i.v.) and oral administration. The pharmacokinetic study found the absolute bioavailabilities of low, medium and high doses were 61.1, 51.5 and 42.5 %, respectively, indicating that the absolute bioavailability was effectively improved.
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agriculture University, No. 2888 Xincheng Street, Changchun, 130118, Jilin, China. zhyjlu79@163.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agriculture University, No. 2888 Xincheng Street, Changchun, 130118, Jilin, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Tang
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agriculture University, No. 2888 Xincheng Street, Changchun, 130118, Jilin, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Tang
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agriculture University, No. 2888 Xincheng Street, Changchun, 130118, Jilin, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agriculture University, No. 2888 Xincheng Street, Changchun, 130118, Jilin, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Hou
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agriculture University, No. 2888 Xincheng Street, Changchun, 130118, Jilin, China.
authors.forename: Enbo
authors.initials: E
authors.lastname: Cai
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agriculture University, No. 2888 Xincheng Street, Changchun, 130118, Jilin, China.
authors.forename: Shuangli
authors.initials: S
authors.lastname: Liu
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agriculture University, No. 2888 Xincheng Street, Changchun, 130118, Jilin, China.
authors.forename: Daihong
authors.initials: D
authors.lastname: Lei
authors.affiliation: College of Chinese Medicinal Materials, Jilin Agriculture University, No. 2888 Xincheng Street, Changchun, 130118, Jilin, China. zlx863@163.com.
authors.forename: Lianxue
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Traditional Chinese Medicine, Jilin Agricultural Science and Technology University, No 77, Hanlin Road, Jilin, 132101, Jilin, China.
authors.forename: Shijie
authors.initials: S
authors.lastname: Wang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D005260:Female; D005638:Fruit / Q000737:chemistry; D029762:Garcinia mangostana / Q000737:chemistry; D008297:Male; D010936:Plant Extracts / Q000737:chemistry* / Q000493:pharmacokinetics*; D010938:Plant Oils / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D044004:Xanthones / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: D010936:Plant Extracts; D010938:Plant Oils; D044004:Xanthones; C009689:xanthone; C021053:mangostin