title: Lead Exposure in Different Organs of Mammals and Prevention by Curcumin-Nanocurcumin: a Review.
abstract: Chronic lead exposure is related to many health diseases in mammals. Exposure to lead forms reactive oxygen species reducing body antioxidant enzymes inflicting injury to numerous macromolecules or cell necrosis. Recent studies have revealed oxidative stress as the vital mechanism for lead toxicity. Lead is found to be toxic to several organ systems such as hematopoietic, skeletal, renal, cardiac, hepatic, and reproductive systems and extremely toxic to the central nervous system (CNS). Curcumin, an active ingredient of the dietary spice, and nanocurcumin, a nanoform of curcumin, are found to decrease toxicity due to lead in various organ systems in mouse models. Higher bioavailability, chelating property, and retention time of nanocurcumin over bulk curcumin may pave the way to expand the utility of nanocurcumin to remove lead toxicity from various organ systems within humans.
authors.affiliation: School of biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal, 462033, Madhya Pradesh, India. mili.pal2@gmail.com.
authors.forename: Mili
authors.initials: M
authors.lastname: Pal
authors.affiliation: School of biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal, 462033, Madhya Pradesh, India. meenusachdeva9sep92@gmail.com.
authors.forename: Meenu
authors.initials: M
authors.lastname: Sachdeva
authors.affiliation: School of biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal, 462033, Madhya Pradesh, India. niharikagpt4@gmail.com.
authors.forename: Niharika
authors.initials: N
authors.lastname: Gupta
authors.affiliation: School of biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal, 462033, Madhya Pradesh, India. priyankapharma25@gmail.com.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Mishra
authors.affiliation: School of biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal, 462033, Madhya Pradesh, India. mahaviryadav@rgpv.net.
authors.forename: Mahavir
authors.initials: M
authors.lastname: Yadav
authors.affiliation: School of biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Gandhi Nagar, Bhopal, 462033, Madhya Pradesh, India. archanargpv@gmail.com.
authors.forename: Archana
authors.initials: A
authors.lastname: Tiwari
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D001682:Biological Availability; D001842:Bone and Bones / Q000187:drug effects; D002490:Central Nervous System; D002614:Chelating Agents / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry*; D006321:Heart / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects; D007854:Lead / Q000633:toxicity*; D007855:Lead Poisoning / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects; D008322:Mammals; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry; D009336:Necrosis; D009474:Neurons / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species
chemical_list: D000975:Antioxidants; D002614:Chelating Agents; D017382:Reactive Oxygen Species; D007854:Lead; D003474:Curcumin
keywords: Curcumin; Lead toxicity; Nanocurcumin; Oxidative stress