title: [Two-year incidence of new immune-mediated inflammatory diseases in patients with inflammatory bowel disease: A study in the AQUILES cohort].
abstract: OBJECTIVE
  To describe the 2-year incidence of new immune-mediated inflammatory diseases (spondylarthritis, uveitis, psoriasis) in the cohort of patients with inflammatory bowel disease (IBD) included in the AQUILES study.
  
  
  METHODS
  Over a 2-year period, 341 patients with IBD (53% women, mean age 40 years) diagnosed with Crohn's disease (60.5%), ulcerative colitis (38.1%) and indeterminate colitis (1.4%) were followed up. New diagnoses made during follow-up were based on reports of the corresponding specialists (rheumatologists, ophthalmologists, and dermatologists).
  
  
  RESULTS
  A total of 22 new diagnoses of immune-mediated inflammatory diseases were established in 21 patients (cumulative incidence of 6.5%, 95% confidence interval [CI] 3.7-9.2, incidence rate of 26 cases per 10,000 patient-years). Most diagnoses were new cases of spondylarthritis (n=15). The cumulative incidence of new diagnoses of immune-mediated inflammatory diseases was similar in patients with Crohn's disease (5.8%, 95% CI 3.4-9.9) and in patients with ulcerative colitis (7.7%, 95% CI 4.2-13.6). On multivariate analysis, the incidence of new immune-mediated inflammatory diseases was significantly associated with a family history of IBD (odds ratio=3.6, 95% CI 1.4-9.4) and the presence of extraintestinal manifestations of IBD (odds ratio=1.8, 95% CI .7-5.2).
  
  
  CONCLUSIONS
  In patients with IBD, the incidence of new immune-mediated inflammatory diseases at 2 years of follow-up was 6.5%. These diseases were more frequent in patients with extraintestinal manifestations of IBD and a family history of IBD.
authors.affiliation: Departamento de Gastroenterología, Hospital Gregorio Marañón, Madrid, España.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Marín-Jiménez
authors.affiliation: Departamento de Gastroenterología, Hospital de La Princesa, IP y CIBERehd, Madrid, España.
authors.forename: Javier P
authors.initials: JP
authors.lastname: Gisbert
authors.affiliation: Departamento de Gastroenterología, Hospital Fundación Alcorcón , Madrid, España.
authors.forename: José L
authors.initials: JL
authors.lastname: Pérez-Calle
authors.affiliation: Departamento de Gastroenterología, Hospital Reina Sofía-IMIBIC y CIBEREHD, Córdoba, España.
authors.forename: Valle
authors.initials: V
authors.lastname: García-Sánchez
authors.affiliation: Departamento de Gastroenterología, Hospital Príncipe de Asturias, Madrid, España.
authors.forename: Susana
authors.initials: S
authors.lastname: Tabernero
authors.affiliation: Departamento de Reumatología, Hospital de la Princesa, IISP, Madrid, España.
authors.forename: Rosario
authors.initials: R
authors.lastname: García-Vicuña
authors.affiliation: Departamento de Medical Affairs, Merck Sharp & Dohme de España, Madrid, España.
authors.forename: Cristina
authors.initials: C
authors.lastname: Romero
authors.affiliation: Departamento de Medical Affairs, Merck Sharp & Dohme de España, Madrid, España.
authors.forename: Berta
authors.initials: B
authors.lastname: Juliá
authors.affiliation: Departamento de Dermatología, Hospital 12 de Octubre , Madrid, España.
authors.forename: Francisco
authors.initials: F
authors.lastname: Vanaclocha
authors.affiliation: Departamento de Medical Affairs, Merck Sharp & Dohme de España, Madrid, España. Electronic address: luis.cea@merck.com.
authors.forename: Luis
authors.initials: L
authors.lastname: Cea-Calvo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D015212:Inflammatory Bowel Diseases / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D011565:Psoriasis / Q000453:epidemiology* / Q000276:immunology; D013030:Spain / Q000453:epidemiology; D025241:Spondylarthritis / Q000453:epidemiology* / Q000276:immunology; D014605:Uveitis / Q000453:epidemiology* / Q000276:immunology; D055815:Young Adult
keywords: Colitis ulcerosa; Crohn's disease; Enfermedad de Crohn; Enfermedad inflamatoria intestinal; Espondiloartritis; Inflammatory bowel disease; Psoriasis; Spondylarthritis; Uveitis; Uveítis; ulcerative colitis