title: Association of uric acid with traditional inflammatory factors in stroke.
abstract: Uric acid (UA) plays an important role in the oxidant stress that causes inflammation. We assessed the association between UA and neutrophil ratio, white blood cell (WBC) count and blood lipid in 524 patients admitted with stroke. Stroke patients with a neutrophil ratio >70% displayed significantly lower UA levels than those with a neutrophil ratio ≤70% (p < 0.05). According to UA quartiles, neutrophil ratio, WBC count, and high-density lipoprotein cholesterol in the UA grade 1 group (≤214.10 μmol/L) were significantly increased over those in other UA grade groups. The results of stepwise regression analysis found that UA levels were inversely associated with neutrophil ratios (B ± SE = -1.11 ± 0.35), high-density lipoprotein cholesterol (B ± SE = -46.18 ± 14.17), total cholesterol (B ± SE = 9.82 ± 3.66), blood urea nitrogen (B ± SE = 6.30 ± 1.73), and creatinine (B ± SE = 0.63 ± 0.10). There is a correlationship between lower serum uric acid with neutrophil ratios in inflammation associated with stroke and the reasons need to be investigated further.
authors.affiliation: a Nursing School of Central South University; The Second Xiangya Hospital of Central South University ; Changsha , Hunan 410013 , China.
authors.forename: Aiqun
authors.initials: A
authors.lastname: Zhu
authors.affiliation: b Department of Neurology, The Second Xiangya Hospital , Central South University , Changsha , Hunan 410011 , China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zou
authors.affiliation: c Department of Emergency, The Second Xiangya Hospital , Central South University , Changsha , Hunan 410011 , China.
authors.forename: Guangzhong
authors.initials: G
authors.lastname: Xiong
authors.affiliation: d Nursing School of Central South University , Changsha , Hunan 410013 , China.
authors.forename: Jingping
authors.initials: J
authors.lastname: Zhang
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000097:blood / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood*
chemical_list: D018836:Inflammation Mediators; D014527:Uric Acid
keywords: inflammation; neutrophil ratio; stroke; uric acid