title: High-grade urothelial carcinoma in a kidney transplant recipient with BK virus infection.
abstract: Bladder malignancy in the kidney transplant recipient is rare and compared with the general population tends to be of high grade and have an aggressive clinical course. In this report, we describe a case of urothelial carcinoma developing in a kidney transplant recipient 6 years after the diagnosis of polyomavirus nephropathy (PVN). BK virus (BKV) DNA was identified in urine and serum by PCR. The diffuse strong staining of SV40 T-antigen and p53 within both the in situ and invasive carcinoma suggest that BKV may play a role in the oncogenic pathway in this clinical setting.
authors.affiliation: Department of Anatomical Pathology.
authors.forename: Prue
authors.initials: P
authors.lastname: Hill
authors.affiliation: Department of Anatomical Pathology.
authors.forename: John
authors.initials: J
authors.lastname: Slavin
authors.affiliation: Department of Nephrology , St Vincent's Hospital , Fitzroy 3065, Victoria , Australia.
authors.forename: David
authors.initials: D
authors.lastname: Goodman
keywords: BK virus; PVN; kidney transplant; urothelial carcinoma