title: Copper-catalyzed reactions: Research in the gas phase.
abstract: Electrospray ionization mass spectrometry (ESI-MS) is becoming an important tool for mechanistic studies in organic and organometallic chemistry. It allows investigation of reaction mixtures including monitoring of reactants, products, and intermediates, studying properties of the intermediates and their reactivity. Studying the reactive species in the gas phase can be advantageously combined with theoretical calculations. This review is focused on ESI-MS studies of copper-catalyzed reactions. Possible effects of the electrospray process on the transfer of the copper complexes to the gas phase are discussed. The plethora of mass spectrometric approaches is demonstrated on copper mediated C-H activations, cross coupling reactions, rearrangements, organocuprate chemistry, and other examples.
authors.affiliation: Department of Organic Chemistry, Charles University in Prague, Faculty of Science; Hlavova 2030, 128 40 Prague 2, Czech Republic.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Tsybizova
authors.affiliation: Department of Organic Chemistry, Charles University in Prague, Faculty of Science; Hlavova 2030, 128 40 Prague 2, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Roithová
keywords: DFT calculation; copper catalysis; electrospray ionization; mass spectrometry; reaction mechanism; reaction monitoring