title: RNA G-Quadruplex: The New Potential Targets for Therapy.
abstract: Roles of RNA on transcriptional and post-transcriptional regulations have raised more attention since the new era of genomics. One of the secondary structures of RNA, the RNA Gquadruplex structure, is demonstrated a relatively stable existence in human tumor cells, virus, or other species relating to diseases. G-quadruplexes are special secondary structures formed by G-rich DNA and RNA sequences that fold into a four-stranded conformation. The G-quadruplexes formed in RNA are involved in many biological process including telomere elongation, transcription regulate, pre-mRNA splicing and translation. In this review, we will give a brief introduction to the structures of RNA G-quadruplexes, the biological roles and the potential to be as drug targets.
authors.forename: Shi-Ke
authors.initials: SK
authors.lastname: Wang
authors.forename: Yue
authors.initials: Y
authors.lastname: Wu
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, 132 Waihuan East Road, Guangzhou University City, Guangzhou 510006, P.R. China. outianm@mail.sysu.edu.cn.
authors.forename: Tian-Miao
authors.initials: TM
authors.lastname: Ou
mesh_terms: D000818:Animals; D054856:G-Quadruplexes / Q000187:drug effects*; D006801:Humans; D012313:RNA / Q000737:chemistry* / Q000187:drug effects* / Q000378:metabolism
chemical_list: D012313:RNA