title: Synthesis, spectral, thermal, fluorescence, antimicrobial, anthelmintic and DNA cleavage studies of mononuclear metal chelates of bi-dentate 2H-chromene-2-one Schiff base.
abstract: The Co(II), Ni(II) and Cu(II) complexes have been synthesized with Schiff base (HL), derived from 8-formyl-7-hydroxy-4-methylcoumarin with benzylamine. The Schiff base and its metal complexes were structurally characterized based on IR, (1)H NMR, (13)C NMR, UV-visible, ESR, magnetic, thermal, fluorescence, mass and ESI-MS studies. The complexes are completely soluble in DMF and DMSO. The molar conductance values indicate that, all synthesized metal complexes are non-electrolytic in nature. Elemental analysis reveals [ML2(H2O)2] stoichiometry, here MCo(II), Ni(II) and Cu(II), L=deprotonated ligand. The coordination between metal ion and Schiff base was supported by IR data, through deprotonation of phenolic oxygen of coumarin and azomethine nitrogen atoms. Solution electronic spectral results unveiled that all the synthesized complexes posses six coordinated geometry around metal ion. Thermal studies suggest the presence of coordinated water molecules. The Schiff base and its metal complexes have been screened for their antibacterial (Escherichia coli, Pseudomonas aureginosa, Klebsiella pneumoniae and Staphylococcus aureus) and antifungal (Penicillium chrysogenum and Aspergillus niger), anthelmintic (Pheretima posthuma) and DNA cleavage (Calf Thymus DNA) activities.
authors.affiliation: P.G. Department of Chemistry, Karnatak University, Dharwad 580003, Karnataka, India.
authors.forename: Chetan T
authors.initials: CT
authors.lastname: Prabhakara
authors.affiliation: P.G. Department of Chemistry, Karnatak University, Dharwad 580003, Karnataka, India. Electronic address: patil1956@rediffmail.com.
authors.forename: Sangamesh A
authors.initials: SA
authors.lastname: Patil
authors.affiliation: Department of Chemistry, K.L.S. Gogte Institute of Technology, Belgaum 590008, Karnataka, India.
authors.forename: Ajaykumar D
authors.initials: AD
authors.lastname: Kulkarni
authors.affiliation: Department of Chemistry, V.D.R. Institute of Technology, Haliyal 581329, Karnataka, India.
authors.forename: Vinod H
authors.initials: VH
authors.lastname: Naik
authors.affiliation: Department of Chemistry, C.M.R. Institute of Technology, Bangalore 560037, Karnataka, India.
authors.forename: M
authors.initials: M
authors.lastname: Manjunatha
authors.affiliation: P.G. Department of Chemistry, Karnatak University, Dharwad 580003, Karnataka, India.
authors.forename: Shivshankar M
authors.initials: SM
authors.lastname: Kinnal
authors.affiliation: Department of Chemistry, Shri Sharanabasaveshwar College of Science, Gulbarga 585102, Karnataka, India.
authors.forename: Prema S
authors.initials: PS
authors.lastname: Badami
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008280:Magnetics; D009532:Nickel / Q000737:chemistry; D009835:Oligochaeta / Q000187:drug effects; D012545:Schiff Bases / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D000871:Anthelmintics; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D056831:Coordination Complexes; D003374:Coumarins; D012545:Schiff Bases; D003035:Cobalt; D003300:Copper; D009532:Nickel; D004247:DNA; C427203:calf thymus DNA; C030123:coumarin
keywords: Anthelmintic; Coumarin Schiff base; DNA cleavage; Fluorescence; Metal complexes