title: Spinal cord compression after radiolabeled metaiodobenzylguanidine analogue therapy in advanced malignant insulinoma.
abstract: Malignant insulinomas are frequently diagnosed at a late stage. Medical management is necessary to slow progression of the disease and control of hypoglycemic symptoms when cure by surgical treatment is not possible. Multimodal treatment, in these cases, has been used with variable clinical response. We describe a 68-yr-old woman who presented response failure to usual treatment and was alternatively treated with radiolabeled metaiodobenzylguanidine ([131I]-MIBG) analogue therapy with development of neurologic complications. We also present a review of the current role of [131I]-MIBG treatment in insulinomas.
authors.affiliation: Departament of Internal Medicine, Santa Izabel Hospital, Bahiana School of Medicine, Salvador, BA, Brazil.
authors.forename: Alina Coutinho Rodrigues
authors.initials: AC
authors.lastname: Feitosa
authors.affiliation: Departament of Oncology, Santa Izabel Hospital, Salvador, BA,, Brazil.
authors.forename: Dálvaro Oliveira de
authors.initials: DO
authors.lastname: Castro Júnior
authors.affiliation: Departament of Radiology, Santa Izabel Hospital, Salvador, BA, Brazil.
authors.forename: José
authors.initials: J
authors.lastname: Rocha Filho
authors.affiliation: Departament of Oncology, Santa Izabel Hospital, Salvador, BA,, Brazil.
authors.forename: Melba
authors.initials: M
authors.lastname: Moura
authors.affiliation: Departament of Radiology, Santa Izabel Hospital, Salvador, BA, Brazil.
authors.forename: Marcony Queiroz
authors.initials: MQ
authors.lastname: Andrade
authors.affiliation: Departament of Nuclear Medicina, Santa Izabel Hospital, Salvador, BA, Brazil.
authors.forename: Adelina
authors.initials: A
authors.lastname: Sanches
mesh_terms: D019797:3-Iodobenzylguanidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007340:Insulinoma / Q000532:radiotherapy* / Q000556:secondary; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D010190:Pancreatic Neoplasms / Q000532:radiotherapy*; D019275:Radiopharmaceuticals / Q000009:adverse effects*; D013117:Spinal Cord Compression / Q000209:etiology*
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine