title: HOMA-IR Values are Associated With Glycemic Control in Japanese Subjects Without Diabetes or Obesity: The KOBE Study.
abstract: BACKGROUND
  Several studies have reported that insulin resistance was a major risk factor for the onset of type 2 diabetes mellitus in individuals without diabetes or obesity. We aimed to clarify the association between insulin resistance and glycemic control in Japanese subjects without diabetes or obesity.
  
  
  METHODS
  We conducted a community-based cross-sectional study including 1083 healthy subjects (323 men and 760 women) in an urban area. We performed multivariate regression analyses to estimate the association between the homeostasis model assessment of insulin resistance (HOMA-IR) values and markers of glycemic control, including glycated haemoglobin (HbA1c), 1,5-anhydroglucitol (1,5-AG), and fasting plasma glucose (FPG) levels, after adjustment for potential confounders.
  
  
  RESULTS
  Compared with the lowest tertile of HOMA-IR values, the highest tertile was significantly associated with HbA1c and FPG levels after adjustment for potential confounders, both in men (HbA1c: β = 1.83, P = 0.001; FPG: β = 0.49, P < 0.001) and women (HbA1c: β = 0.82, P = 0.008; FPG: β = 0.39, P < 0.001). The highest tertile of HOMA-IR values was inversely associated with 1,5-AG levels compared with the lowest tertile (β = -18.42, P = 0.009) only in men.
  
  
  CONCLUSIONS
  HOMA-IR values were associated with markers of glycemic control in Japanese subjects without diabetes or obesity. Insulin resistance may influence glycemic control even in a lean, non-diabetic Asian population.
authors.affiliation: Foundation for Biomedical Research and Innovation.
authors.forename: Takumi
authors.initials: T
authors.lastname: Hirata
authors.forename: Aya
authors.initials: A
authors.lastname: Higashiyama
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Kubota
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Nishimura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sugiyama
authors.forename: Aya
authors.initials: A
authors.lastname: Kadota
authors.forename: Yoko
authors.initials: Y
authors.lastname: Nishida
authors.forename: Hironori
authors.initials: H
authors.lastname: Imano
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Naomi
authors.initials: N
authors.lastname: Miyamatsu
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Tomonori
authors.initials: T
authors.lastname: Okamura
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003847:Deoxyglucose / Q000097:blood*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005215:Fasting / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009765:Obesity / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D003847:Deoxyglucose; D006442:Glycated Hemoglobin; C006584:1,5-anhydroglucitol