title: Differential mucin expression by respiratory syncytial virus and human metapneumovirus infection in human epithelial cells.
abstract: Mucins (MUC) constitute an important component of the inflammatory and innate immune response. However, the expression of these molecules by respiratory viral infections is still largely unknown. Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two close-related paramyxoviruses that can cause severe low respiratory tract disease in infants and young children worldwide. Currently, there is not vaccine available for neither virus. In this work, we explored the differential expression of MUC by RSV and hMPV in human epithelial cells. Our data indicate that the MUC expression by RSV and hMPV differs significantly, as we observed a stronger induction of MUC8, MUC15, MUC20, MUC21, and MUC22 by RSV infection while the expression of MUC1, MUC2, and MUC5B was dominated by the infection with hMPV. These results may contribute to the different immune response induced by these two respiratory viruses.
authors.affiliation: Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
authors.forename: Ma Del Rocío
authors.initials: Mdel R
authors.lastname: Baños-Lara
authors.affiliation: Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.
authors.forename: Boyang
authors.identifier: 0000-0001-7707-4858
authors.initials: B
authors.lastname: Piao
authors.affiliation: Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA ; Center for Experimental Infectious Disease Research, Louisiana State University, Baton Rouge, LA 70803, USA.
authors.forename: Antonieta
authors.initials: A
authors.lastname: Guerrero-Plata
mesh_terms: D000818:Animals; D002460:Cell Line; D004847:Epithelial Cells / Q000378:metabolism* / Q000821:virology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D029121:Metapneumovirus / Q000502:physiology*; D051379:Mice; D018396:Mucin-1 / Q000235:genetics; D055262:Mucin-2 / Q000235:genetics; D055257:Mucin-5B / Q000235:genetics; D009077:Mucins / Q000235:genetics*; D018113:Respiratory Syncytial Virus, Human / Q000502:physiology*
chemical_list: C060192:MUC1 protein, human; C460499:MUC15 protein, human; C524625:MUC2 protein, human; C490965:MUC20 protein, human; C527666:MUC21 protein, human; C524578:MUC5B protein, human; C105059:MUC8 protein, human; D008562:Membrane Glycoproteins; D018396:Mucin-1; D055262:Mucin-2; D055257:Mucin-5B; D009077:Mucins