title: Ferulic acid and Alzheimer's disease: promises and pitfalls.
abstract: Oxidative stress plays an important role in both initiation and progression of neurodegenerative diseases, such as Alzheimer and Parkinson. Therefore, much attention has been paid to antioxidants for developing therapeutic strategies for the neurodegenerative diseases. However, as serious adverse effects are related to synthetic antioxidants, recent research has been focused on natural products especially phenolic antioxidants. In the present article, we critically review the available literature related to the beneficial role of ferulic acid on Alzheimer's disease, since it is a natural antioxidant which is widely found in different fruits and vegetables. We also provide some informations about sources, chemical structure, bioavailability and clinical impacts of ferulic acid.
authors.forename: Seyed Fazel
authors.initials: SF
authors.lastname: Nabavi
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi-630 004, Tamil Nadu, India. devikasi@yahoo.com.
authors.forename: Kasi Pandima
authors.initials: KP
authors.lastname: Devi
authors.forename: Dicson Sheeja
authors.initials: DS
authors.lastname: Malar
authors.forename: Antoni
authors.initials: A
authors.lastname: Sureda
authors.forename: Maria
authors.initials: M
authors.lastname: Daglia
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Nabavi
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002802:Cholinesterases / Q000737:chemistry / Q000378:metabolism; D003373:Coumaric Acids / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D005309:Ferula / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress / Q000187:drug effects; D056811:Unfolded Protein Response / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D003373:Coumaric Acids; C004999:ferulic acid; D002802:Cholinesterases