title: LMNA-related dilated cardiomyopathy.
abstract: A case of idiopathic dilated cardiomyopathy (DCM) that is likely to be associated with LMNA mutation Arg190Pro in a heterozygote is described. The features of DCM in the patient were conduction disorders, cardiac arrhythmias, progressive heart failure and minor musculoskeletal disturbances. We consider that the mutation Arg190Pro contributes to the formation of a weak nuclear lamina and diminishes muscle mechanical stability which is critical during cardiac contraction. The case report illustrates in detail the phenotypic manifestations of the novel LMNA mutation and difficulties in management related to it.
authors.affiliation: Cardiology , Republican Scientific and Practical Center of Cardiology , Minsk , Belarus.
authors.forename: Tatiyana
authors.initials: T
authors.lastname: Vaikhanskaya
authors.affiliation: Cytoplasmic Inheritance , Institute of Genetics and Cytology, National Academy of Sciences , Minsk , Belarus.
authors.forename: Larysa
authors.initials: L
authors.lastname: Sivitskaya
authors.affiliation: Cytoplasmic Inheritance , Institute of Genetics and Cytology, National Academy of Sciences , Minsk , Belarus.
authors.forename: Nina
authors.initials: N
authors.lastname: Danilenko
authors.affiliation: Cytoplasmic Inheritance , Institute of Genetics and Cytology, National Academy of Sciences , Minsk , Belarus.
authors.forename: Oleg
authors.initials: O
authors.lastname: Davydenko
authors.affiliation: Cardiology , Republican Scientific and Practical Center of Cardiology , Minsk , Belarus.
authors.forename: Tatsiyana
authors.initials: T
authors.lastname: Kurushka
authors.affiliation: Cardiology , Republican Scientific and Practical Center of Cardiology , Minsk , Belarus.
authors.forename: Irina
authors.initials: I
authors.lastname: Sidorenko