title: Recent advances in pancreatic cancer: biology, treatment, and prevention.
abstract: Pancreatic cancer (PC) is the fourth leading cause of cancer-related death in United States. Efforts have been made towards the development of the viable solution for its treatment with constrained accomplishment because of its complex biology. It is well established that pancreatic cancer stem cells (CSCs), albeit present in a little count, contribute incredibly to PC initiation, progression, and metastasis. Customary chemo and radiotherapeutic alternatives, however, expands general survival, the related side effects are the significant concern. Amid the most recent decade, our insight about molecular and cellular pathways involved in PC and role of CSCs in its progression has increased enormously. Presently the focus is to target CSCs. The herbal products have gained much consideration recently as they, usually, sensitize CSCs to chemotherapy and target molecular signaling involved in various tumors including PC. Some planned studies have indicated promising results proposing that examinations in this course have a lot to offer for the treatment of PC. Although preclinical studies uncovered the importance of herbal products in attenuating pancreatic carcinoma, limited studies have been conducted to evaluate their role in clinics. The present review provides a new insight to recent advances in pancreatic cancer biology, treatment and current status of herbal products in its anticipation.
authors.affiliation: Department of Biology, City College of New York, 160 Convent Avenue, New York, NY 10031, USA. Electronic address: divyasingh28sep@gmail.com.
authors.forename: Divya
authors.initials: D
authors.lastname: Singh
authors.affiliation: Department of Biology, City College of New York, 160 Convent Avenue, New York, NY 10031, USA. Electronic address: upadhyayiitr@gmail.com.
authors.forename: Ghanshyam
authors.initials: G
authors.lastname: Upadhyay
authors.affiliation: Kansas City VA Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA. Electronic address: rsrivastava.lab@gmail.com.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Srivastava
authors.affiliation: Kansas City VA Medical Center, 4801 Linwood Boulevard, Kansas City, MO 64128, USA; Department of Pathology, School of Medicine, University of Missouri-Kansas City, Kansas City, MO 64108, USA. Electronic address: sharmila.shankar@va.gov.
authors.forename: Sharmila
authors.initials: S
authors.lastname: Shankar
mesh_terms: D006801:Humans; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000517:prevention & control / Q000628:therapy
keywords: Cancer prevention; Cancer stem cell; Natural Product; Pancreatic cancer; Signaling pathways