title: Medium-term and long-term outcomes following placement of midurethral slings for stress urinary incontinence: a systematic review and metaanalysis.
abstract: OBJECTIVE
  Questions regarding the long-term efficacy and safety of midurethral slings (MUS) are still unresolved, notwithstanding the widespread use of these procedures. The objective of this review was to evaluate the long-term outcomes of retropubic MUS (RP-MUS) procedures and the medium-term outcomes of transobturator MUS (TO-MUS) procedures.
  
  
  METHODS
  MEDLINE, EMBASE, NLH, ClinicalTrials.gov, and Google Scholar databases were searched up to June 2014 with restriction to English language and using the search terms: "stress urinary incontinence", "midurethral sling", "tension-free tape", "transobturator tape", and "follow-up". Studies with a follow-up of 36 months for TO-MUS and 60 months for RP-MUS were searched. Only studies comparing a RP-MUS or TO-MUS with another synthetic sling were included. Data from 49 studies were included. Data were expressed as odds ratios (OR) with 95 % confidence intervals (CI) and combined using the Mantel-Haenszel fixed effects model. Differences in the proportions were evaluated using the chi-squared test.
  
  
  RESULTS
  RP-MUS had similar objective cure rates (OR 1.15, 95 % CI 0.75 - 1.76) but higher subjective cure rates than TO-MUS (OR 1.76, 95 % CI 1.08 - 2.86). No differences were observed between outside-in (TOT) and inside-out (TVT-O) and between TO-MUS and minisling. Bladder injuries were more frequent (OR 7.01, 95 % CI 2.94 - 17.90) and vaginal erosions were less frequent for RP-MUS (OR 0.24, 95 % CI 0.07 - 0.84). Vaginal injuries were more common with TOT than with TVT-O (OR 7.96, 95 % CI 1.15 - 157.9). Pain-related complications were more common with TO-MUS than with minimally invasive tapes (OR 8.75; 95 % CI 9.02 - 57.90).
  
  
  CONCLUSIONS
  MUS have similar objective cure rates in the long term and medium term. TO-MUS is associated with a lower subjective cure rate than RP-MUS.
authors.affiliation: Department of Obstetrics and Gynecology, University of Naples "Federico II", Via S. Pansini, 5, Naples, 80131, Italy, gtommaselli@yahoo.it.
authors.forename: Giovanni A
authors.initials: GA
authors.lastname: Tommaselli
authors.forename: Costantino
authors.initials: C
authors.lastname: Di Carlo
authors.forename: Carmen
authors.initials: C
authors.lastname: Formisano
authors.forename: Annamaria
authors.initials: A
authors.lastname: Fabozzi
authors.forename: Carmine
authors.initials: C
authors.lastname: Nappi
mesh_terms: D005260:Female; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D053825:Suburethral Slings / Q000009:adverse effects / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D014550:Urinary Incontinence, Stress / Q000601:surgery*