title: The effects of bromazepam over the central and frontal areas during a motor task: an EEG study.
abstract: The present study investigates the influence of bromazepam while executing a motor task. Specifically, we intend to analyze the changes in alpha absolute power under two experimental conditions, bromazepam and placebo. We also included analyses of theta and beta frequencies. We collected electroencephalographic data before, during, and after motor task execution. We used a Two Way ANOVA to investigate the condition (PL × Br6 mg) and moment (pre and post) variables for the following electrodes: Fp1, Fp2, F7, F3, Fz, F4, F8, C3, CZ and C4. We found a main effect for condition on the electrodes FP1, F7, F3, Fz, F4, C3 and CZ, for alpha and beta bands. For beta band we also found a main effect for condition on the electrodes Fp2, F8 and C4; for theta band we identified a main effect for condition on C3, Cz and C4 electrodes. This finding suggests that the motor task did not have any influence on the electrocortical activity in alpha, and that the existing modifications were a consequence due merely to the drug use. Despite its anxiolytic and sedative action, bromazepam did not show any significant changes when the individuals executed a finger extension motor task.
authors.affiliation: Departamento de Neurofisiologia e Neuropsicologia, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Suzete
authors.initials: S
authors.lastname: Fortunato
authors.affiliation: Departamento de Neurofisiologia e Neuropsicologia, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Guaraci Ken
authors.initials: GK
authors.lastname: Tanaka
authors.affiliation: Departamento de Neurofisiologia e Neuropsicologia, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Araújo
authors.affiliation: Departamento de Neurofisiologia e Neuropsicologia, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Bittencourt
authors.affiliation: Departamento de Neurofisiologia e Neuropsicologia, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Danielle
authors.initials: D
authors.lastname: Aprigio
authors.affiliation: Departamento de Mapeamento Cerebral e Integração Sensorial, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Mariana
authors.initials: M
authors.lastname: Gongora
authors.affiliation: Laboratório de Mapeamento Cerebral e Funcional, Universidade Federal do Piauí, Teresina, PI, Brazil.
authors.forename: Silmar
authors.initials: S
authors.lastname: Teixeira
authors.affiliation: Departamento de Biociências, Faculdade de Educação Física, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Fernando Augusto Monteiro Saboia
authors.initials: FA
authors.lastname: Pompeu
authors.affiliation: Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Cagy
authors.affiliation: Laboratório de Psicofisiologia, Faculdade da Saúde, Universidade Metodista de São Paulo, Sao Paulo, SP, Brazil.
authors.forename: Luis F
authors.initials: LF
authors.lastname: Basile
authors.affiliation: Departamento de Mapeamento Cerebral e Integração Sensorial, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Pedro
authors.initials: P
authors.lastname: Ribeiro
authors.affiliation: Departamento de Neurofisiologia e Neuropsicologia, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
authors.forename: Bruna
authors.initials: B
authors.lastname: Velasques
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D058256:Brain Waves / Q000187:drug effects; D001960:Bromazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects*; D012016:Reference Values; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000502:physiology; D013647:Task Performance and Analysis; D013997:Time Factors; D055815:Young Adult
chemical_list: D014151:Anti-Anxiety Agents; D001960:Bromazepam