title: Detection of cytomegalovirus in an immunocompetent adult presenting with acute retinal necrosis due to varicella-zoster virus: a case report.
abstract: BACKGROUND
  To report a case of simultaneous detection of cytomegalovirus (CMV) in acute retinal necrosis (ARN) due to varicella-zoster virus (VZV) in an immunocompetent adult.
  
  
  METHODS
  A 65-year-old healthy woman presented with necrotizing retinitis. Vitreous, tears, saliva, and swabs of the auricular and forehead skin areas were collected and tested by polymerase chain reaction analysis at various time points during the treatment period.
  
  
  RESULTS
  VZV and CMV DNA were detected in the vitreous, tears, saliva, and skin. CMV was present in fewer copies than VZV in the vitreous. The retinal lesion clinically improved rapidly only by acyclovir. According to the clinical findings and the clinical responses to acyclovir, CMV seems not to cause ARN in this case.
  
  
  CONCLUSIONS
  VZV and CMV DNA were detected in the vitreous of a patient with VZV ARN. CMV reactivation appeared to be asymptomatic.
authors.affiliation: Department of Ophthalmology, University of Toyama, Toyama, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Department of Virology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Daikoku
authors.affiliation: Department of Virology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
authors.forename: Kimiyasu
authors.initials: K
authors.lastname: Shiraki
authors.affiliation: Department of Ophthalmology, University of Toyama, Toyama, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hayashi
keywords: acute retinal necrosis; cytomegalovirus; immunocompetent patient; polymerase chain reaction; varicella-zoster virus