title: A draft genome for the African crocodilian trypanosome Trypanosoma grayi.
abstract: The availability of genome sequence data has greatly enhanced our understanding of the adaptations of trypanosomatid parasites to their respective host environments. However, these studies remain somewhat restricted by modest taxon sampling, generally due to focus on the most important pathogens of humans. To address this problem, at least in part, we are releasing a draft genome sequence for the African crocodilian trypanosome, Trypanosoma grayi ANR4. This dataset comprises genomic DNA sequences assembled de novo into contigs, encompassing over 10,000 annotated putative open reading frames and predicted protein products. Using phylogenomic approaches we demonstrate that T. grayi is more closely related to Trypanosoma cruzi than it is to the African trypanosomes T. brucei, T. congolense and T. vivax, despite the fact T. grayi and the African trypanosomes are each transmitted by tsetse flies. The data are deposited in publicly accessible repositories where we hope they will prove useful to the community in evolutionary studies of the trypanosomatids.
authors.affiliation: Department of Plant Sciences, University of Oxford , Oxford OX1 3RB, UK.
authors.forename: Steven
authors.initials: S
authors.lastname: Kelly
authors.affiliation: Centre for Immunity, Infection and Evolution, Ashworth Laboratories, University of Edinburgh , Edinburgh EH9 3JT, UK.
authors.forename: Alasdair
authors.initials: A
authors.lastname: Ivens
authors.affiliation: Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee DD1 5EH, Scotland, UK.
authors.forename: Paul T
authors.initials: PT
authors.lastname: Manna
authors.affiliation: School of Biological Sciences, University of Bristol , Bristol BS8 1UG, UK.
authors.forename: Wendy
authors.initials: W
authors.lastname: Gibson
authors.affiliation: Division of Biological Chemistry and Drug Discovery, University of Dundee , Dundee DD1 5EH, Scotland, UK.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Field
mesh_terms: D000818:Animals; D016054:DNA, Protozoan; D018503:Genome, Protozoan; D010802:Phylogeny; D014345:Trypanosoma / Q000235:genetics*
chemical_list: D016054:DNA, Protozoan