title: Antitumor and antimetastatic effects of pemetrexed-loaded targeted nanoparticles in B16bearing mice.
abstract: Using nanoparticle delivery for anticancer therapy is a potential new drug modality. We developed a novel gelatinase-stimuli nanoparticle. In this study, we studied the antitumor and antimetastasis effect of pemetrexed-loaded targeted nanoparticles and evaluated the correlation between E-cadherin expression and lung metastasis in subcutaneous xenograft model. Compared with free pemetrexed, pemetrexed-loaded targeted nanoparticles exhibited the best antitumor and antimetastasis efficacy among the four therapeutic groups. The study also indicated that there was an inverse correlation between lung metastasis and E-cadherin expression. These results showed pemetrexed-loaded targeted nanoparticles may be a potent drug for tumor therapy and our preclinical data could provide new direction for clinical therapy of malignant melanoma.
authors.affiliation: a Department of Oncology , The Affiliated Provincial Hospital, Anhui Medical University , Hefei , PR China.
authors.forename: Nannan
authors.initials: N
authors.lastname: Lu
authors.affiliation: b The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University , Nanjing , PR China.
authors.forename: Rutian
authors.initials: R
authors.lastname: Li
authors.affiliation: b The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University , Nanjing , PR China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Liu
authors.affiliation: a Department of Oncology , The Affiliated Provincial Hospital, Anhui Medical University , Hefei , PR China.
authors.forename: Bing
authors.initials: B
authors.lastname: Hu
authors.affiliation: c Respiratory Medicine, The Affiliated Provincial Hospital, Anhui Medical University , Hefei , PR China , and.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Xu
authors.affiliation: a Department of Oncology , The Affiliated Provincial Hospital, Anhui Medical University , Hefei , PR China.
authors.forename: Chushu
authors.initials: C
authors.lastname: Ji
authors.affiliation: a Department of Oncology , The Affiliated Provincial Hospital, Anhui Medical University , Hefei , PR China.
authors.forename: Xinghua
authors.initials: X
authors.lastname: Han
authors.affiliation: d Drum Tower Clinical Medical College of Nanjing Medical University , Nanjing , PR China.
authors.forename: Pin
authors.initials: P
authors.lastname: Wang
authors.affiliation: b The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University , Nanjing , PR China.
authors.forename: Baorui
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems / Q000379:methods*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008546:Melanoma, Experimental / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D000068437:Pemetrexed; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D000068437:Pemetrexed; D011092:Polyethylene Glycols
keywords: Antimetastsis; PEG–Peptide–PCL nanoparticles; antitumor; drug delivery; pemetrexed