title: Novel roles of TMEM100: inhibition metastasis and proliferation of hepatocellular carcinoma.
abstract: Transmembrane protein 100 (TMEM100) was activated by ALK1/TGF-β signaling. We found that TMEM100 was decreased in hepatocellular carcinoma (HCC) tissues and in highly metastatic cell lines. Overexpressed of TMEM100 inhibited invasion, migration and proliferation. Low levels of TMEM100 were associated with cirrhosis, tumor size, Tumor nodule number, TNM stage, BCLC stage, Edmondson-Steiner Stage and vein invasion. Furthermore, TMEM100 was an independent risk factor for overall survival (P = 0.03) and disease-free survival (P = 0.019). The current findings suggest that TMEM100 functions as a tumor suppressor in HCC metastasis and proliferation.
authors.affiliation: Department of Geratic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Dipeng
authors.initials: D
authors.lastname: Ou
authors.affiliation: Department of Geratic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Geratic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Hua
authors.affiliation: Department of Geratic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Xiao
authors.affiliation: Department of Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.|Liver Cancer Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Lianyue
authors.initials: L
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D015153:Blotting, Western; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018572:Disease-Free Survival; D005260:Female; D064593:Heterografts; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology*; D016133:Polymerase Chain Reaction; D016016:Proportional Hazards Models; D012307:Risk Factors; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D008565:Membrane Proteins; C584320:TMEM100 protein, human
keywords: HCC; TMEM100; metastasis; prognosis; proliferation