title: Repurposing apoptosis-inducing cancer drugs to treat schistosomiasis.
authors.affiliation: The Walter & Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
authors.forename: Erinna F
authors.initials: EF
authors.lastname: Lee
authors.forename: Walter Douglas
authors.initials: WD
authors.lastname: Fairlie
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D058492:Drug Repositioning / Q000379:methods; D015801:Helminth Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D058990:Molecular Targeted Therapy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D017434:Protein Structure, Tertiary; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000378:metabolism; D012547:Schistosoma / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D012552:Schistosomiasis / Q000188:drug therapy* / Q000469:parasitology; D012556:Schistosomicides / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D015801:Helminth Proteins; D047428:Protein Kinase Inhibitors; D019253:Proto-Oncogene Proteins c-bcl-2; D012556:Schistosomicides
keywords: BH3-mimetic; Bcl-2; apoptosis; cancer drugs; kinase inhibitors; praziquantel; schistosomiasis; small-molecule inhibitor