title: Potyviruses differ in their requirement for TOR signalling.
abstract: Potyviruses are important plant pathogens that rely on many plant cellular processes for successful infection. TOR (target of rapamycin) signalling is a key eukaryotic energy-signalling pathway controlling many cellular processes such as translation and autophagy. The dependence of potyviruses on active TOR signalling was examined. Arabidopsis lines downregulated for TOR by RNAi were challenged with the potyviruses watermelon mosaic virus (WMV) and turnip mosaic virus (TuMV). WMV accumulation was found to be severely altered while TuMV accumulation was only slightly delayed. In another approach, using AZD-8055, an active site inhibitor of the TOR kinase, WMV infection was found to be strongly affected. Moreover, AZD-8055 application can cure WMV infection. In contrast, TuMV infection was not affected by AZD-8055. This suggests that potyviruses have different cellular requirements for active plant TOR signalling.
authors.affiliation: CNRS, UMR 7265 Biologie Végétale & Microbiologie Environnementales, Marseille F-13009, France.|CEA, IBEB, Marseille F-13009, France.|Genetics and Breeding of Fruits and Vegetables, INRA Avignon, UR1052, CS 60094, Montfavet 84143, France.|Aix-Marseille Université, Laboratoire de Génétique et Biophysique des Plantes, Marseille F-13009, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Ouibrahim
authors.affiliation: Genetics and Breeding of Fruits and Vegetables, INRA Avignon, UR1052, CS 60094, Montfavet 84143, France.
authors.forename: Ana Giner
authors.initials: AG
authors.lastname: Rubio
authors.affiliation: Genetics and Breeding of Fruits and Vegetables, INRA Avignon, UR1052, CS 60094, Montfavet 84143, France.
authors.forename: André
authors.initials: A
authors.lastname: Moretti
authors.affiliation: Aix-Marseille Université, Laboratoire de Génétique et Biophysique des Plantes, Marseille F-13009, France.|CNRS, UMR 7265 Biologie Végétale & Microbiologie Environnementales, Marseille F-13009, France.|CEA, IBEB, Marseille F-13009, France.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Montané
authors.affiliation: Aix-Marseille Université, Laboratoire de Génétique et Biophysique des Plantes, Marseille F-13009, France.|CNRS, UMR 7265 Biologie Végétale & Microbiologie Environnementales, Marseille F-13009, France.|CEA, IBEB, Marseille F-13009, France.
authors.forename: Benoît
authors.initials: B
authors.lastname: Menand
authors.affiliation: Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Institut National de la Recherche Agronomique AgroParisTech, Versailles cedex 78026, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Meyer
authors.affiliation: CEA, IBEB, Marseille F-13009, France.|Aix-Marseille Université, Laboratoire de Génétique et Biophysique des Plantes, Marseille F-13009, France.|CNRS, UMR 7265 Biologie Végétale & Microbiologie Environnementales, Marseille F-13009, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Robaglia
authors.affiliation: Genetics and Breeding of Fruits and Vegetables, INRA Avignon, UR1052, CS 60094, Montfavet 84143, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Caranta
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism*; D010935:Plant Diseases / Q000235:genetics / Q000821:virology*; D017800:Potyvirus / Q000145:classification / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D029681:Arabidopsis Proteins; D019869:Phosphatidylinositol 3-Kinases; C512171:TOR protein, Arabidopsis