title: Mitochondrial DNA haplogroups and short-term neurological outcomes of ischemic stroke.
abstract: Stroke is one of the leading causes of death and long-term disability worldwide. Mitochondrial DNA (mtDNA) is a potential contributor for the sex differences of ischemic stroke heritability. Although mtDNA haplogroups were associated with stroke onset, their impacts on stroke outcomes remain unclear. This study aimed to evaluate the impacts of mtDNA haplogroups on short-term outcomes of neurological functions in patients with ischemic stroke. A total of 303 patients were included, and their clinical data and mtDNA sequences were analyzed. Based on the changes between baseline and 14-day follow-up stroke severity, our results showed that haplogroup N9 was an independent protective factor against neurological worsening in acute ischemic stroke patients. These findings supported that mtDNA variants play a role in post-stroke neurological recovery, thus providing evidences for future pharmacological intervention in mitochondrial function.
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Biyang
authors.initials: B
authors.lastname: Cai
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, Jiangsu, China.
authors.forename: Keting
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Wenping
authors.initials: W
authors.lastname: Fan
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Yumeng
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 210002, Jiangsu, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Xie
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Minhui
authors.initials: M
authors.lastname: Dai
authors.affiliation: Department of Neurology, The First People's Hospital of Changzhou, Changzhou 213003, Jiangsu, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Cao
authors.affiliation: Department of Neurology, Yantai Yuhuangding Hospital, Yantai 264000, Shandong, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Bai
authors.affiliation: Department of Neurology, Jinling Hospital, Second Military Medical University, Nanjing 210002, Jiangsu, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Qiliang
authors.initials: Q
authors.lastname: Dai
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Shuyu
authors.initials: S
authors.lastname: Zhou
authors.affiliation: 1] Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China [2] Department of Neurology, The First People's Hospital of Hangzhou, Nanjing Medical University, Hangzhou 310006, Zhejiang, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Wusheng
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Minmin
authors.initials: M
authors.lastname: Ma
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Wenhua
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Xinfeng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China.
authors.forename: Gelin
authors.initials: G
authors.lastname: Xu
mesh_terms: D000368:Aged; D015331:Cohort Studies; D004272:DNA, Mitochondrial / Q000032:analysis / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics; D009474:Neurons / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index; D020521:Stroke / Q000235:genetics / Q000473:pathology*
chemical_list: D004272:DNA, Mitochondrial