title: An IT Architecture for Systems Medicine.
abstract: Systems medicine aims to support treatment of complex diseases like cancer by integrating all available data for the disease. To provide such a decision support in clinical practice, a suitable IT architecture is necessary. We suggest a generic architecture comprised of the following three layers: data representation, decision support, and user interface. For the systems medicine research project "Clinically-applicable, omics-based assessment of survival, side effects, and targets in multiple myeloma" (CLIOMMICS) we developed a concrete instance of the generic architecture. We use i2b2 for representing the harmonized data. Since no deterministic model exists for multiple myeloma we use case-based reasoning for decision support. For clinical practice, visualizations of the results must be intuitive and clear. At the same time, they must communicate the uncertainty immanent in stochastic processes. Thus, we develop a specific user interface for systems medicine based on the web portal software Liferay.
authors.affiliation: University of Heidelberg, Institute of Medical Biometry and Informatics, Heidelberg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Ganzinger
authors.affiliation: University of Heidelberg, Institute of Medical Biometry and Informatics, Heidelberg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Gietzelt
authors.affiliation: University of Heidelberg, Institute of Medical Biometry and Informatics, Heidelberg, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Karmen
authors.affiliation: University of Heidelberg, Institute of Medical Biometry and Informatics, Heidelberg, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Firnkorn
authors.affiliation: University of Heidelberg, Institute of Medical Biometry and Informatics, Heidelberg, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Knaup
mesh_terms: D020000:Decision Support Systems, Clinical / Q000458:organization & administration*; D057286:Electronic Health Records / Q000458:organization & administration*; D062527:Meaningful Use / Q000458:organization & administration; D008498:Medical Record Linkage / Q000379:methods*; D013597:Systems Analysis; D018511:Systems Integration; D014584:User-Computer Interface