title: Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells.
abstract: Bioassay guided fractionation of Cinnamon tamala leaf extracts yielded bornyl acetate (1), caryophylene oxide (2), p-coumaric acid (3) and vanillic acid (4) using A-2780 human ovarian cancer cell lines. The structures of the isolated compounds were confirmed through spectroscopic techniques (EIMS, (1)H and (13)C NMR). Compound 1 exhibited highest cytotoxicity with 90.16 ± 1.06% inhibition (IC50=5.30 x 10(-4) mg/ml) followed by compound 2 (84.40±1.53% inhibition; IC50=8.94 x 10(-3)mg/ml), while compounds 3 and 4 were inactive in the bioassay.
authors.affiliation: Research Lab. II, Department of Chemistry, GC University, Lahore, Pakistan.
authors.forename: Durre
authors.initials: D
authors.lastname: Shahwar
authors.affiliation: Research Lab. II, Department of Chemistry, GC University, Lahore, Pakistan / Department of Chemistry, University of Gujrat, Hafiz Hayat Campus, Gujrat, Pakistan.
authors.forename: Sami
authors.initials: S
authors.lastname: Ullah
authors.affiliation: Research Lab. II, Department of Chemistry, GC University, Lahore, Pakistan.
authors.forename: Mohammad Akmal
authors.initials: MA
authors.lastname: Khan
authors.affiliation: Research Lab. II, Department of Chemistry, GC University, Lahore, Pakistan.
authors.forename: Naeem
authors.initials: N
authors.lastname: Ahmad
authors.affiliation: Research Lab. II, Department of Chemistry, GC University, Lahore, Pakistan.
authors.forename: Afifa
authors.initials: A
authors.lastname: Saeed
authors.affiliation: Research Lab. II, Department of Chemistry, GC University, Lahore, Pakistan.
authors.forename: Saif
authors.initials: S
authors.lastname: Ullah
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001892:Camphanes / Q000494:pharmacology; D002277:Carcinoma; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D027424:Cinnamomum; D003373:Coumaric Acids / Q000494:pharmacology; D006224:Cricetinae; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D000081223:Polycyclic Sesquiterpenes; D011422:Propionates; D012717:Sesquiterpenes / Q000494:pharmacology; D014641:Vanillic Acid / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001892:Camphanes; D003373:Coumaric Acids; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D011422:Propionates; D012717:Sesquiterpenes; C071528:bornyl acetate; D014641:Vanillic Acid; C495469:p-coumaric acid; C515179:caryophyllene oxide