title: Synthesis of enantioenriched 1,2-trans-diamines using the borono-Mannich reaction with N-protected α-amino aldehydes.
abstract: The three-component Petasis borono-Mannich reaction starting with easily accessible N-protected α-amino aldehydes produces efficiently and diastereoselectively 1,2-trans-diamines with an enantiomeric excess of up to 98%.
authors.affiliation: ICSN-CNRS, Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles du CNRS, CNRS UPR 2301, 1 Avenue de la Terrasse, F-91198 Gif-sur-Yvette, France. stephanie.norsikian@cnrs.fr jean-marie.beau@u-psud.fr.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Norsikian
authors.forename: Margaux
authors.initials: M
authors.lastname: Beretta
authors.forename: Alexandre
authors.initials: A
authors.lastname: Cannillo
authors.forename: Amélie
authors.initials: A
authors.lastname: Martin
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Beau
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001895:Boron / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D003959:Diamines; D001895:Boron