title: Prostate cancer mortality in Serbia, 1991-2010: a joinpoint regression analysis.
abstract: The aim of this descriptive epidemiological study was to analyze the mortality trend of prostate cancer in Serbia (excluding the Kosovo and Metohia) from 1991 to 2010.
  
  
  
  The age-standardized prostate cancer mortality rates (per 100 000) were calculated by direct standardization, using the World Standard Population. Average annual percentage of change (AAPC) and the corresponding 95% confidence interval (CI) was computed for trend using the joinpoint regression analysis.
  
  
  
  Significantly increased trend in prostate cancer mortality was recorded in Serbia continuously from 1991 to 2010 (AAPC = +2.2, 95% CI = 1.6-2.9). Mortality rates for prostate cancer showed a significant upward trend in all men aged 50 and over: AAPC (95% CI) was +1.9% (0.1-3.8) in aged 50-59 years, +1.7% (0.9-2.6) in aged 60-69 years, +2.0% (1.2-2.9) in aged 70-79 years and +3.5% (2.4-4.6) in aged 80 years and over. According to comparability test, prostate cancer mortality trends in majority of age groups were parallel (final selected model failed to reject parallelism, P > 0.05).
  
  
  
  The increasing prostate cancer mortality trend implies the need for more effective measures of prevention, screening and early diagnosis, as well as prostate cancer treatment in Serbia.
authors.affiliation: Department of Epidemiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.
authors.forename: Milena
authors.initials: M
authors.lastname: Ilic
authors.affiliation: Student of Integrated Academic Studies for a Doctor of Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Irena
authors.initials: I
authors.lastname: Ilic
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000401:mortality*; D012044:Regression Analysis; D012189:Retrospective Studies; D055771:Serbia / Q000453:epidemiology
keywords: joinpoint regression analysis; mortality; prostate cancer; trend