title: Inhibition effects of Chinese cabbage powder on aflatoxin B1-induced liver cancer.
abstract: In this study, 0.25 μg/ml aflatoxin B1 was used to establish a liver cancer model for assessing the potential anticancer ability of Chinese cabbage powder, which is a complex water-soluble extract from Chinese cabbage by spray-drying at an outlet temperature of 130 °C. We found at least 11 potential anticancer substances in Chinese cabbage powder. A 90-d animal experiment demonstrated that 10% of Chinese cabbage powder in drinking water could improve the plasma micronutrient status, inhibit the formation of aflatoxin B1-DNA adducts in liver cells, and effectively reduce the incidence of liver tumor induced by aflatoxin B1 from 6.67% to 0%. The dose effect experiment revealed that 10% may be the minimal effective dose to prevent the occurrence of early liver tumors. This study will help elucidate the basis of epidemiological observations of dietary cancer prevention in humans, as well as explore related mechanisms.
authors.affiliation: College of Food and Biological Engineering, Qiqihar University, Qiqihar 161006, Heilongjiang, China.
authors.forename: Tuoyi
authors.initials: T
authors.lastname: Wang
authors.affiliation: Clinical Pathological Diagnosis Center, Qiqihar Medical University, Qiqihar 161006, Heilongjiang, China.
authors.forename: Chunyan
authors.initials: C
authors.lastname: Li
authors.affiliation: Clinical Pathological Diagnosis Center, Qiqihar Medical University, Qiqihar 161006, Heilongjiang, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130022, Jilin, China. Electronic address: 56347418@qq.com.
authors.forename: Tiezhu
authors.initials: T
authors.lastname: Li
authors.affiliation: Institute of Agro-food Technology, Jilin Academy of Agricultural Sciences, Changchun 130022, Jilin, China; School of Biological and Agricultural Engineering, Jilin University, Changchun 130022, Jilin, China. Electronic address: 5321755@qq.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: School of Biological and Agricultural Engineering, Jilin University, Changchun 130022, Jilin, China.
authors.forename: Yonghai
authors.initials: Y
authors.lastname: Sun
mesh_terms: D016604:Aflatoxin B1 / Q000737:chemistry*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry*; D001937:Brassica / Q000009:adverse effects*; D018736:DNA Adducts / Q000737:chemistry*; D004032:Diet; D005260:Female; D008099:Liver / Q000187:drug effects; D008113:Liver Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000737:chemistry*; D013696:Temperature; D014867:Water
chemical_list: D016588:Anticarcinogenic Agents; D018736:DNA Adducts; D010936:Plant Extracts; C072611:aflatoxin B1-DNA adduct; D014867:Water; D016604:Aflatoxin B1
keywords: Aflatoxin B(1); Antitumor activities; Chinese cabbage powder; Liver tumor; Vegetable food