title: Enhanced tolerance and antitumor efficacy by docetaxel-loaded albumin nanoparticles.
abstract: Docetaxel is one of the most active chemotherapeutic agents for cancer treatment. The traditional docetaxel injection (TAXOTERE®) is currently formulated in the surfactant polysorbate 80, which has been associated with severe adverse reactions. To avoid the use of polysorbate 80 as well as to reduce the systemic toxicity of docetaxel, in this study, docetaxel-loaded albumin nanoparticles were fabricated by a novel simple self-assembly method. The resulting nanoparticles showed a mean diameter size of 150 nm. After being encapsulated into nanoparticles, docetaxel displayed similar cytotoxicity to traditional injection. Since polysorbate 80 was not involved in nanoparticles, the hemolysis was completely eliminated. The maximal tolerance dose of nanoparticles was also increased, which allowed a higher dose to be safely intravenously injected and produced ideal antitumor effects. The 150 nm diameter also allowed the nanoparticles to accumulate in tumor tissue via the enhanced permeability and retention effect. The passive targeting ability further caused the higher antitumor effects of nanoparticles than that of traditional injection at the same dose (7.5 mg/kg). Therefore, docetaxel-loaded albumin nanoparticles fabricated by our strategy showed higher promise in their safety and effectiveness than the traditional docetaxel injection.
authors.affiliation: a Medical School & State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing , P. R. China.
authors.forename: Xiaolei
authors.initials: X
authors.lastname: Tang
authors.affiliation: a Medical School & State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing , P. R. China.
authors.forename: Guijun
authors.initials: G
authors.lastname: Wang
authors.affiliation: a Medical School & State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing , P. R. China.
authors.forename: Runjie
authors.initials: R
authors.lastname: Shi
authors.affiliation: a Medical School & State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing , P. R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Jiang
authors.affiliation: a Medical School & State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing , P. R. China.
authors.forename: Lingtong
authors.initials: L
authors.lastname: Meng
authors.affiliation: a Medical School & State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing , P. R. China.
authors.forename: Hao
authors.initials: H
authors.lastname: Ren
authors.affiliation: a Medical School & State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing , P. R. China.
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wu
authors.affiliation: a Medical School & State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing , P. R. China.
authors.forename: Yiqiao
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000072283:A549 Cells; D000418:Albumins / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry*; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D000077143:Docetaxel; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D061986:MCF-7 Cells; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010539:Permeability; D011136:Polysorbates / Q000737:chemistry; D011817:Rabbits; D043823:Taxoids / Q000008:administration & dosage* / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D000418:Albumins; D000970:Antineoplastic Agents; D004337:Drug Carriers; D011136:Polysorbates; D043823:Taxoids; D000077143:Docetaxel
keywords: Albumin; cancer chemotherapy; drug delivery system; nanoparticles; self-assembly