title: Efficient synthesis and antimicrobial evaluation of some Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones.
abstract: BACKGROUND
  Thiazolidinone, has been employed in the preparation of different important drugs required for treatment of inflammations, bacterial infections, and hypertension. Mannich bases have been shown to exhibit diverse biological activities, such as antibacterial, and antifungal activities. Spiroheterocycles including thiazolidine moiety have antimicrobial activity.
  
  
  RESULTS
  In this study, a novel, rapid, and efficient protocol is developed for the synthesis of various 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones using sodium dodecylbenzene sulfonate (DBSNa) as an inexpensive and readily available reagent in acetic acid at room temperature. High yields, easy work-up, and short reaction times are advantages of this procedure. The synthesized arylidines were undergone Mannich reaction with formaldehyde and secondary amines in absolute ethanol at room temperature to afford the corresponding N-Mannich bases. All prepared Mannich bases were evaluated for their antimicrobial activity.
  
  
  CONCLUSIONS
  Good activity was noted for Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones, with some members recorded higher antimicrobial activity. Graphical abstractSynthesis of Mannich bases of 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones.
authors.affiliation: Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia ; Department of Chemistry, Faculty of Science, Assiut University, Assiut, 71516 Egypt.
authors.forename: Essam M
authors.initials: EM
authors.lastname: Hussein
authors.affiliation: Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
authors.forename: Ghada S
authors.initials: GS
authors.lastname: Masaret
authors.affiliation: Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
authors.forename: Khalid S
authors.initials: KS
authors.lastname: Khairou
keywords: 1-thia-4-azaspiro[4.5]decan-3-one; Antimicrobial activity; Mannich bases; Sodium dodecylbenzene sulfonate; Spiro