title: A Review on Mechanisms of Anti Tumor Activity of Chalcones.
abstract: Chalcones comprise a characteristic framework of 1, 3-diaryl-2-propen-1-one. They have been heralded as promising anti cancer drugs and have received much attention in the field of cancer research and drug development. The cytotoxicity of these potent pharmacophores is attributable to a wide spectrum of biological activities like anti inflammatory, anti proliferative, anti fungal, etc. These anti tumor activities are effectuated through apoptosis, cell cycle arrest, anti tubulin and so forth. This review summarizes the recent developments on anti tumor activity of synthetic and natural chalcones and their detailed underlying mechanisms as reported in the past.
authors.forename: Rahul
authors.initials: R
authors.lastname: Sharma
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Rishi
authors.initials: R
authors.lastname: Kodwani
authors.forename: Sukriti
authors.initials: S
authors.lastname: Kapoor
authors.forename: Anukriti
authors.initials: A
authors.lastname: Khare
authors.forename: Ritu
authors.initials: R
authors.lastname: Bansal
authors.forename: Sonali
authors.initials: S
authors.lastname: Khurana
authors.forename: Sandhya
authors.initials: S
authors.lastname: Singh
authors.forename: Jennifer
authors.initials: J
authors.lastname: Thomas
authors.forename: Bornika
authors.initials: B
authors.lastname: Roy
authors.forename: Rajendra
authors.initials: R
authors.lastname: Phartyal
authors.forename: Shukla
authors.initials: S
authors.lastname: Saluja
authors.affiliation: Sri Venkateswara College, University of Delhi, Delhi - 110021, India. skbatra20@gmail.com.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D047188:Chalcones / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones; D014404:Tubulin