title: Associations between metabolomic-identified changes of biomarkers and arterial stiffness in subjects progressing to impaired fasting glucose.
abstract: OBJECTIVE
  We investigated correlations between age-related changes in circulating metabolites and arterial stiffness in impaired fasting glucose (IFG).
  This prospective cohort study included 602 healthy, normal fasting glucose (NFG) subjects (30-65 years old) who underwent triennial medical evaluation. After 3 years, 9·3% of subjects developed IFG (n = 56). Age, gender, BMI and fasting glucose were used to match the remaining NFG subjects (n = 546) that were included for the control group (NFG group, n = 80).
  
  
  RESULTS
  After 3 years, levels of fasting glucose, insulin and malondialdehyde, and brachial-ankle pulse wave velocity (baPWV) were significantly greater in the IFG group than in the NFG group after adjusting for baseline values. The IFG group had a greater increase in lactosylceramide (P = 0·001, q < 0·05) and a greater reduction in phosphatidylcholine (PC) (18:0/20:4) than the NFG group. Multiple linear regression analysis showed that the change in baPWV was independently and positively associated with changes in fasting glucose and lactosylceramide. In all subjects, lactosylceramide levels positively correlated with changes in baPWV and fasting glucose, while premenopausal women were not shown, and negatively correlated with changes in PC and LDL particle size.
  
  
  CONCLUSIONS
  This study indicates that age-related increase in circulating lactosylceramide is an independent predictor of increased arterial stiffness in subjects with impaired fasting glucose.
authors.affiliation: National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea.|Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea.
authors.forename: Saem
authors.initials: S
authors.lastname: Jung
authors.affiliation: Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Korea.
authors.forename: Minjoo
authors.initials: M
authors.lastname: Kim
authors.affiliation: National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea.|Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea.
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Department of Family Practice, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, Korea.|Department of Food and Nutrition, Brain Korea 21 PLUS Project, College of Human Ecology, Yonsei University, Seoul, Korea.|Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, Korea.
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D055109:Ankle Brachial Index; D000886:Anthropometry; D015703:Antigens, CD / Q000097:blood*; D015415:Biomarkers / Q000378:metabolism*; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D004032:Diet; D005215:Fasting; D005260:Female; D006706:Homeostasis; D006801:Humans; D007790:Lactosylceramides / Q000097:blood*; D016014:Linear Models; D008077:Lipoproteins, LDL / Q000032:analysis; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D055442:Metabolome; D008875:Middle Aged; D010316:Particle Size; D010713:Phosphatidylcholines / Q000097:blood; D011446:Prospective Studies; D059289:Vascular Stiffness
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D001786:Blood Glucose; D007790:Lactosylceramides; D008077:Lipoproteins, LDL; D010713:Phosphatidylcholines; C009744:CDw17 antigen; D008315:Malondialdehyde; D002097:C-Reactive Protein