title: Developmental toxicity assessment of the new turf herbicide, methiozolin ([5-(2,6-difluorobenzyl)oxymethyl-5-methyl-3,3(3-methylthiophen-2-yl)-1,2-isoxazoline]), in rabbits.
abstract: Methiozolin is a new herbicide to control annual bluegrass (Poa annua L.) and large crabgrass (Digitaria sanguinalis (L.) Scop.) in various turfgrasses. The potential of methiozolin to induce maternal and developmental toxicity was investigated in the pregnant New Zealand White Rabbits. Methiozolin was, at dose levels of 0, 125, 250 and 500 mg/kg/day, administered by oral gavage to artificially inseminated rabbits (25 females per group) from days 6 to 28 of gestation. All does were subjected to Cesarean section on day 29 of gestation. At 500 mg/kg/day, treatment-related toxicities including abortion (10/22), decreased mean body weight, weight gain, net body weight change, reduced food consumption and decreased fetal weight were observed. At 125 and 250 mg/kg/day, no signs of maternal and developmental toxicity were observed. There were no treatment-related external, visceral and skeletal abnormalities of fetuses at all doses tested. In the current experimental conditions, the no observed adverse effect levels (NOAELs) of methiozolin are considered to be 250 mg/kg/day for does and prenatal development.
authors.affiliation: Division of Toxicological Research and Evaluation, Korea Institute of Toxicology, Daejeon, Republic of Korea.
authors.forename: Jinsoo
authors.initials: J
authors.lastname: Lee
authors.affiliation: Division of Toxicological Research and Evaluation, Korea Institute of Toxicology, Daejeon, Republic of Korea.
authors.forename: Jeongah
authors.initials: J
authors.lastname: Song
authors.affiliation: Division of Toxicological Research and Evaluation, Korea Institute of Toxicology, Daejeon, Republic of Korea.
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Jeong
authors.affiliation: Division of Toxicological Research and Evaluation, Korea Institute of Toxicology, Daejeon, Republic of Korea.
authors.forename: Moon-Koo
authors.initials: MK
authors.lastname: Chung
authors.affiliation: Moghu Research Center Ltd., Daejeon, Republic of Korea.
authors.forename: Ki-Hwan
authors.initials: KH
authors.lastname: Hwang
authors.affiliation: Moghu Research Center Ltd., Daejeon, Republic of Korea.
authors.forename: Suk-Jin
authors.initials: SJ
authors.lastname: Koo
authors.affiliation: Division of Toxicological Research and Evaluation, Korea Institute of Toxicology, Daejeon, Republic of Korea. Electronic address: yuwj@kitox.re.kr.
authors.forename: Wook-Joon
authors.initials: WJ
authors.lastname: Yu
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D007555:Isoxazoles / Q000633:toxicity*; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D011247:Pregnancy; D011256:Pregnancy Outcome; D011817:Rabbits; D013876:Thiophenes / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D006540:Herbicides; D007555:Isoxazoles; D013876:Thiophenes; C585332:methiozolin
keywords: Developmental toxicity; Methiozolin; Rabbit; Safety evaluation; Turf herbicide