title: Development of acquired factor V inhibitor after treatment with ceftazidime: a case report and review of the literature.
abstract: We report the case of a 59-year-old Chinese man who showed an asymptomatic coagulation factor V deficiency pattern after second intravenous treatment with ceftazidime. Normal pooled plasma failed to correct the abnormalities in a mixing test, and the presence of factor V inhibitor was confirmed by the Bethesda method. The coagulopathy was not corrected by transfusion of fresh frozen plasma and prothrombin complex concentrate, but rather by treatment with prednisone and withdrawal of dubious drugs. The findings reported here should prompt clinicians to watch for drug-induced coagulation factor deficiency.
authors.affiliation: Department of Hematology, PLA 100th Hospital, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
authors.forename: Qing-ya
authors.initials: QY
authors.lastname: Cui
authors.affiliation: Department of Hematology, PLA 100th Hospital, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
authors.forename: Hong-shi
authors.initials: HS
authors.lastname: Shen
authors.affiliation: Department of Hematology, PLA 100th Hospital, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
authors.forename: Tian-qin
authors.initials: TQ
authors.lastname: Wu
authors.affiliation: Department of Hematology, PLA 100th Hospital, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
authors.forename: Hai-fei
authors.initials: HF
authors.lastname: Chen
authors.affiliation: Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
authors.forename: Zi-qiang
authors.initials: ZQ
authors.lastname: Yu
authors.affiliation: Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.
authors.forename: Zhao-yue
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001780:Blood Coagulation Tests; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000473:pathology; D002442:Ceftazidime / Q000009:adverse effects* / Q000627:therapeutic use; D005165:Factor V / Q000037:antagonists & inhibitors*; D005166:Factor V Deficiency / Q000139:chemically induced* / Q000188:drug therapy*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010949:Plasma; D011241:Prednisone / Q000627:therapeutic use; D011516:Prothrombin / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005165:Factor V; D011516:Prothrombin; D002442:Ceftazidime; D011241:Prednisone
keywords: acquired factor V deficiency; coagulopathy; prednisone