title: Perfluoroalkyl substances (PFAS) including structural PFOS isomers in plasma from elderly men and women from Sweden: Results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS).
abstract: Per- and polyfluoroalkyl substances (PFASs) are a class of compounds with unique chemical properties that have been shown useful in a wide variety of applications because they provide materials with reduced surface tension and exceptional non-stick properties. PFASs are commonly found in impregnation materials, coatings of papers and textiles, fire-fighting foams, pesticides, and cleaning agents. The potential for human exposure to PFASs is high because of their widespread distribution. The aim of this study was to investigate levels of PFASs in men and women from Sweden and to assess the influence of gender and parity among women. Levels of 13 PFASs were determined in plasma samples collected during 2001-2004 from 1016 (507 women) 70year-old participants from the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). The PFASs studied were nine perfluorinated carboxylic acids (PFCAs), four perfluorinated sulfonic acids (PFSAs) and perfluorooctane sulfonamide (PFOSA). In addition, structural isomers of perfluorooctane sulfonic acid (PFOS) were determined in a subset of 398 individuals. The detection rates were high and the majority of the studied compounds were detected in more than 75% of the participants. Levels of the selected analytes were found to be similar to other studies of non-occupationally exposed populations. Gender differences were observed in levels of PFHpA which was higher in men, while PFHxS was higher in women. Parity among women was shown to have a minor effect on PFAS concentrations and we found primi- and multiparous women to have slightly lower levels of PFUnDA when compared to nulliparous women.
authors.affiliation: Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, SE-751 83 Uppsala, Sweden; MTM Research Centre, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden. Electronic address: samira.salihovic@medsci.uu.se.
authors.forename: Samira
authors.initials: S
authors.lastname: Salihovic
authors.affiliation: MTM Research Centre, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Kärrman
authors.affiliation: Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.
authors.forename: Lars
authors.initials: L
authors.lastname: Lind
authors.affiliation: Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.
authors.forename: P Monica
authors.initials: PM
authors.lastname: Lind
authors.affiliation: MTM Research Centre, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden.
authors.forename: Gunilla
authors.initials: G
authors.lastname: Lindström
authors.affiliation: MTM Research Centre, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden.
authors.forename: Bert
authors.initials: B
authors.lastname: van Bavel
mesh_terms: D000368:Aged; D017738:Alkanesulfonic Acids; D002264:Carboxylic Acids; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D008297:Male; D010298:Parity; D010575:Pesticides; D011247:Pregnancy; D011446:Prospective Studies; D013548:Sweden
chemical_list: D017738:Alkanesulfonic Acids; D002264:Carboxylic Acids; D004785:Environmental Pollutants; D005466:Fluorocarbons; D010575:Pesticides; C073608:perfluorooctane; C076994:perfluorooctane sulfonic acid
keywords: Biomonitoring; Gender; Human plasma; PFOA; PFOS; Perfluoroalkyl substances; Structural isomers