title: Comparison of nedaplatin-based versus cisplatin-based chemotherapy for advanced non-small cell lung cancer among East Asian populations: A meta-analysis.
abstract: Whether nedaplatin and cisplatin are equally effective for advanced non-small cell lung cancer (NSCLC) remains uncertain. Therefore, we performed a meta-analysis of trials to compare nedaplatin-based chemotherapy with cisplatin-based chemotherapy. We conducted a literature search to identify trials that had investigated the substitution of nedaplatin for cisplatin in the treatment of advanced NSCLC. Fourteen randomized controlled trials were included. We found equivalent overall response, overall survival, and survival probability (0.5-year, 1-year). Considering the toxicity profiles, nausea and vomiting were common in the cisplatin group (OR = 0.28, 95% CI = 0.20-0.40, P < 0.001), whereas severe thrombocytopenia was common in the nedaplatin group (OR = 1.68, 95% CI = 1.18-2.40, P = 0.005). A subgroup analysis of grades 1-4 nephrotoxicity showed that cisplatin-based chemotherapy resulted in more renal toxicity (OR = 0.40, 95% CI = 0.24-0.68, P = 0.001). No significant heterogeneity and publication bias were observed. Cumulative analysis found a stable time-dependent trend. Consistent results stratified by age, regimen, and country were observed. Cisplatin-based chemotherapy was associated with non-inferior antitumor efficacy compared with nedaplatin-based therapy. Therefore, the toxicity profile might play an important role in choosing between cisplatin-based or nedaplatin-based regimens.
authors.affiliation: Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital, Nanjing Medical University.
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital, Nanjing Medical University.
authors.forename: Shaorong
authors.initials: S
authors.lastname: Yu
authors.affiliation: Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital, Nanjing Medical University.
authors.forename: Siwen
authors.initials: S
authors.lastname: Liu
authors.affiliation: Research Center of Clinical Oncology, the Affiliated Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu 210009, China.
authors.forename: Haixia
authors.initials: H
authors.lastname: Cao
authors.affiliation: Research Center of Clinical Oncology, the Affiliated Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu 210009, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Ma
authors.affiliation: Research Center of Clinical Oncology, the Affiliated Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu 210009, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital, Nanjing Medical University.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Feng
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D044466:Asian People; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use*; D016208:Databases, Factual; D005202:Asia, Eastern; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D009325:Nausea / Q000209:etiology; D016017:Odds Ratio; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D012044:Regression Analysis; D015996:Survival Rate; D013921:Thrombocytopenia / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C053989:nedaplatin; D002945:Cisplatin