title: A Top-Down Cortical Circuit for Accurate Sensory Perception.
abstract: A fundamental issue in cortical processing of sensory information is whether top-down control circuits from higher brain areas to primary sensory areas not only modulate but actively engage in perception. Here, we report the identification of a neural circuit for top-down control in the mouse somatosensory system. The circuit consisted of a long-range reciprocal projection between M2 secondary motor cortex and S1 primary somatosensory cortex. In vivo physiological recordings revealed that sensory stimulation induced sequential S1 to M2 followed by M2 to S1 neural activity. The top-down projection from M2 to S1 initiated dendritic spikes and persistent firing of S1 layer 5 (L5) neurons. Optogenetic inhibition of M2 input to S1 decreased L5 firing and the accurate perception of tactile surfaces. These findings demonstrate that recurrent input to sensory areas is essential for accurate perception and provide a physiological model for one type of top-down control circuit.
authors.affiliation: Laboratory for Behavioral Neurophysiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Manita
authors.affiliation: Laboratory for Behavioral Neurophysiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Laboratory for Behavioral Neurophysiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Homma
authors.affiliation: Laboratory for Behavioral Neurophysiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsumoto
authors.affiliation: Laboratory for Behavioral Neurophysiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan.
authors.forename: Maya
authors.initials: M
authors.lastname: Odagawa
authors.affiliation: Laboratory for Behavioral Neurophysiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Yamada
authors.affiliation: Laboratory for Behavioral Neurophysiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan; JSPS Research Fellow, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo, 102-0083, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ota
authors.affiliation: Laboratory for Behavioral Neurophysiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Matsubara
authors.affiliation: Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furocho, Chikusa-ku, Nagoya City, Aichi, 464-8601, Japan.
authors.forename: Ayumu
authors.initials: A
authors.lastname: Inutsuka
authors.affiliation: Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan; PRESTO, Japan Science and Technology Agency, 4-1-8 Honmachi, Kawaguchi City, Saitama, 332-0012, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sato
authors.affiliation: Saitama University Graduate School of Science and Engineering, 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama, 338-8570, Japan; Saitama University Brain Science Institute, 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama, 338-8570, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Ohkura
authors.affiliation: Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Furocho, Chikusa-ku, Nagoya City, Aichi, 464-8601, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yamanaka
authors.affiliation: Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi City, Gunma, 371-8511, Japan.
authors.forename: Yuchio
authors.initials: Y
authors.lastname: Yanagawa
authors.affiliation: Saitama University Graduate School of Science and Engineering, 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama, 338-8570, Japan; Saitama University Brain Science Institute, 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama, 338-8570, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Nakai
authors.affiliation: Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan; Saitama University Graduate School of Science and Engineering, 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama, 338-8570, Japan; Saitama University Brain Science Institute, 255 Shimo-Okubo, Sakura-ku, Saitama City, Saitama, 338-8570, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Hayashi
authors.affiliation: NeuroCure Cluster of Excellence, Humboldt University, Charitéplatz 1, D-10117 Berlin, Germany.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Larkum
authors.affiliation: Laboratory for Behavioral Neurophysiology, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako City, Saitama, 351-0198, Japan. Electronic address: masa_murayama@brain.riken.jp.
authors.forename: Masanori
authors.initials: M
authors.lastname: Murayama
mesh_terms: D000818:Animals; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009415:Nerve Net / Q000502:physiology*; D062308:Optogenetics / Q000379:methods; D012677:Sensation / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D014110:Touch / Q000502:physiology*