title: Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells.
abstract: In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil samples. SENP5 is an enzyme that targets and cleaves small ubiquitin-like modifier (SUMO) residues from SUMOylated proteins. Further investigation with AML neutrophil differentiation cell models showed increased SENP5 expression upon induction of differentiation; in contrast, knocking down SENP5 resulted in significantly attenuated neutrophil differentiation. Our results support a new role of SENP5 in AML pathology, and in particular in the neutrophil differentiation of myeloid leukemic cells.
authors.affiliation: Division of Experimental Pathology, Institute of Pathology, University of Bern, Switzerland ; Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, United States.
authors.forename: Elena A
authors.initials: EA
authors.lastname: Federzoni
authors.affiliation: Division of Experimental Pathology, Institute of Pathology, University of Bern, Switzerland.
authors.forename: Severin
authors.initials: S
authors.lastname: Gloor
authors.affiliation: Division of Experimental Pathology, Institute of Pathology, University of Bern, Switzerland ; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.affiliation: Division of Experimental Pathology, Institute of Pathology, University of Bern, Switzerland.
authors.forename: Deborah
authors.initials: D
authors.lastname: Shan-Krauer
authors.affiliation: Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland.
authors.forename: Martin F
authors.initials: MF
authors.lastname: Fey
authors.affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, United States.
authors.forename: Bruce E
authors.initials: BE
authors.lastname: Torbett
authors.affiliation: Division of Experimental Pathology, Institute of Pathology, University of Bern, Switzerland ; Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
authors.forename: Mario P
authors.initials: MP
authors.lastname: Tschan
keywords: AML; Acute myeloid leukemia; Neutrophil differentiation; SENP5; SUMO protease