title: Endothelial nitric oxide synthase genotypes modulate peripheral vasodilatory properties after myocardial infarction.
abstract: BACKGROUND
  Studies in population genetics suggest an important relationship between the eNOS G894T polymorphism and occurrence of acute myocardial infarction (AMI), with little known on its influence on the post-AMI period.
  
  
  OBJECTIVE
  To investigate the association of allelic variants produced by the G894T transversion in eNOS (rs1799983) with post-AMI variables.
  
  
  METHODS
  Cross-sectional analyses of anthropometric, clinical and laboratory assessments obtained within the first 24h and after 5 and 30 days of the AMI event across T carriers and G homozygotes of eNOS in 371 consecutive cases of AMI with ST-segment elevation admitted to a Brazilian emergency service in cardiology. Genotypes were determined by polymerase chain reaction followed by enzymatic restriction.
  
  
  RESULTS
  Despite no difference between genotypic groups on aspects as Killip-Kimbal classification scores, extension of infarcted mass, lipid profile or pattern of medication use, an increase in serum nitric oxide from admission to day 5 was higher for T carriers (p<0.001). Thirty days post-AMI, peripheral blood flow reserve was larger among T carriers either by flow- (p=0.037) and nitrate-mediated (p=0.040) dilation testing.
  
  
  CONCLUSIONS
  Our results suggest an association of the eNOS 894T allele with an apparent improvement in late arterial function in post-AMI patients.
authors.affiliation: Universidade de Brasília (UnB), Brasília, DF, Brazil. Electronic address: wilcellymachado@gmail.com.
authors.forename: Wilcelly
authors.initials: W
authors.lastname: Machado-Silva
authors.affiliation: Universidade de Brasília (UnB), Brasília, DF, Brazil. Electronic address: ralfkreis@yahoo.com.br.
authors.forename: Rossana
authors.initials: R
authors.lastname: Alfinito-Kreis
authors.affiliation: Universidade de Brasília (UnB), Brasília, DF, Brazil. Electronic address: luizsergiofc@gmail.com.
authors.forename: Luiz Sérgio F
authors.initials: LS
authors.lastname: Carvalho
authors.affiliation: Hospital de Base do Distrito Federal, Brasília, DF, Brazil. Electronic address: jcquinaglia@hotmail.com.
authors.forename: José C
authors.initials: JC
authors.lastname: Quinaglia-E-Silva
authors.affiliation: Hospital de Base do Distrito Federal, Brasília, DF, Brazil. Electronic address: rangeldealmeida@globo.com.
authors.forename: Osório L R
authors.initials: OL
authors.lastname: Almeida
authors.affiliation: Universidade Católica de Brasília (UCB-DF), Taguatinga, DF, Brazil. Electronic address: cirojbrito@gmail.com.
authors.forename: Ciro J
authors.initials: CJ
authors.lastname: Brito
authors.affiliation: Núcleo Interdisciplinar de Pesquisa, Faculdades Promove, Brasília, DF, Brazil.
authors.forename: Aparecido P
authors.initials: AP
authors.lastname: Ferreira
authors.affiliation: Universidade Católica de Brasília (UCB-DF), Taguatinga, DF, Brazil. Electronic address: cordova@ucb.br.
authors.forename: Cláudio
authors.initials: C
authors.lastname: Córdova
authors.affiliation: Universidade de Brasília (UnB), Brasília, DF, Brazil; Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: andreisposito@gmail.com.
authors.forename: Andrei C
authors.initials: AC
authors.lastname: Sposito
authors.affiliation: Universidade de Brasília (UnB), Brasília, DF, Brazil. Electronic address: otavionobrega@unb.br.
authors.forename: Otávio T
authors.initials: OT
authors.lastname: Nóbrega
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D020127:Recovery of Function; D014664:Vasodilation
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III
keywords: Myocardial infarction; Nitric oxide; Polymorphism; Vascular endothelium; Vasodilation