title: Counterion-Specific Protein Adsorption on Polyelectrolyte Brushes.
abstract: Protein adsorption is an important issue in biorelated fields. We have investigated the protein adsorption on the poly(ionic liquid) (PIL) brushes in the presence of different types of counterions. The protein adsorption is driven by a decrease in osmotic pressure within the brushes with an increase in entropy via the release of counterions. Our study demonstrates that counterion specificity has a significant influence on protein adsorption on the PIL brushes. There have been two different regimes for counterion-specific protein adsorption. When the released counterions cannot bind to the protein surface, the counterion-specific protein adsorption is dominated by the ion-specific counterion condensation within the PIL brushes. If the released counterions can bind to the protein surface, then counterion-specific protein adsorption is dominated by the ion-specific rebinding of released counterions on the protein surface. This work opens up a new opportunity for controlling protein adsorption on polyelectrolyte brushes.
authors.affiliation: †Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: †Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, PR China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Hua
authors.affiliation: †Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: ‡Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.affiliation: †Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, PR China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Liu
authors.affiliation: ‡Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, PR China.
authors.forename: Guangzhao
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000327:Adsorption; D004573:Electrolytes / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004573:Electrolytes; D052578:Ionic Liquids; D011108:Polymers; D011506:Proteins