title: [Flavonol glycosides from Lysimachia clethroides].
abstract: Eleven flavonol glycosides were isolated from the ethanol extract of Lysimachia clethroides by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, and reversed-phase HPLC. Their structures were identified as astragalin (1), isoquercitrin (2), isorhamnetin-3-O-β-D-glucopyranoside (3), quercetin-3-O-β-D-6"-acetylglucopyranoside (4), quercetin-7-O-β-D-glucopyranoside (5), prunin (6), 2-hydroxynaringin-5-O-β-D-glucopyranoside (7), kaempferol-3-O-rutinonoside (8), kaempferol-3-O-robinobioside (9), rutin (10) and kaempferol-3,7-di-O-β-D-glucopyranoside (11). Among them, compounds 4, 7 and 11 were obtained from the Lysimachia genus for the first time, while compounds 3, 5 and 9 were firstly reported from this plant. In the preliminary assays, compounds 2, 6 and 8 possessed significant inhibition against aldose reduc- tase, with IC50 values of 2.69, 1.00, 1.80 μmol · L(-1), respectively; none of compounds 1-11 exhibited obvious cytotoxic activity (IC50 > 10 μmol · L(-1)).
authors.forename: Dong
authors.initials: D
authors.lastname: Liang
authors.forename: Yan-Fei
authors.initials: YF
authors.lastname: Liu
authors.forename: Zhi-You
authors.initials: ZY
authors.lastname: Hao
authors.forename: Huan
authors.initials: H
authors.lastname: Luo
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Chun-Lei
authors.initials: CL
authors.lastname: Zhang
authors.forename: Qing-Jian
authors.initials: QJ
authors.lastname: Zhang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D044948:Flavonols / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D015394:Molecular Structure; D029623:Primulaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D004365:Drugs, Chinese Herbal; D044948:Flavonols; D006027:Glycosides