title: [The influence of depression on the course of coronary heart disease and quality of life].
abstract: We undertook the analysis of cardiovascular risk factors and psycho-social factors in 230 patients with coronary heart disease (CHD) based at a city polyclinic. Ninety (31.1%) patients suffered depression (19-28 CES-D scores). Patients with and without depression were significantly different in terms of clinical and functional manifestations of stable angina of effort, cardiovascular risk factors, gender; and psycho-social factors. CHD with depression was associated with a higher FC of angina of effort, risk of adverse outcome (Duke index), frequency of concomitant pathology, psycho-social stress, loss of working capacity and a lower income levels. These patients treated with selective antidepressants (serotonin reuptake inhibitors) for 6 months experienced a marked decrease in the degree of depression and manifestation of its symptoms, improvedpsycho- social protection and quality of life compared with untreated patients. These data illustrate pathogenetic and behavioural mechanisms underlying the relationship between CHD and depression.
authors.forename: N P
authors.initials: NP
authors.lastname: Garganeeva
authors.forename: M M
authors.initials: MM
authors.lastname: Petrova
authors.forename: A A
authors.initials: AA
authors.lastname: Evsyukov
authors.forename: S Yu
authors.initials: SY
authors.lastname: Shtarik
authors.forename: D S
authors.initials: DS
authors.lastname: Kaskaeva
mesh_terms: D000787:Angina Pectoris / Q000453:epidemiology / Q000503:physiopathology*; D015897:Comorbidity; D003327:Coronary Disease / Q000453:epidemiology / Q000503:physiopathology*; D003863:Depression / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D012307:Risk Factors; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors