title: Design of ultrasensitive DNA-based fluorescent pH sensitive nanodevices.
abstract: Here we tune the pH sensitivity of a DNA-based conformational switch, called the I-switch, to yield a set of fluorescent pH sensitive nanodevices with a collective, expanded pH sensing regime from 5.3 to 7.5. The expanded pH regime of this new family of I-switches originates from a dramatic improvement in the overall percentage signal change in response to pH of these nanodevices.
authors.affiliation: National Centre for Biological Sciences, TIFR, GKVK, Bellary Road, Bangalore 560 065, India.
authors.forename: Saheli
authors.initials: S
authors.lastname: Halder
authors.forename: Yamuna
authors.initials: Y
authors.lastname: Krishnan
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D049329:Nanostructures / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D012680:Sensitivity and Specificity
chemical_list: D005456:Fluorescent Dyes; D004247:DNA