title: Dietary fatty acid intakes are related to the risk of ulcerative colitis: a case-control study.
abstract: BACKGROUND
  The role of dietary fatty acids in ulcerative colitis (UC) pathogenesis has been shown in animal models; however, human studies are rare. We hypothesized that there might be a relationship between dietary fatty acid composition and the risk of developing incident UC.
  
  
  METHODS
  Overall, 62 new cases of UC and 124 healthy age and sex-matched controls were studied. Information on usual diet was measured by a validated country-specific food frequency questionnaire (FFQ). Logistic regression analysis adjusting for potential confounding variables was carried out to compare dietary fatty acid intakes between cases and controls.
  
  
  RESULTS
  We found positive associations between dietary intake of total fat (P value for trend <0.01), oleic acid (P value for trend <0.01), saturated fatty acid (SAFA) (P value for trend = 0.02), total polyunsaturated fatty acid (PUFA) (P value for trend = 0.04), and trans fat (P value for trend <0.01).
  
  
  CONCLUSIONS
  Our results showed that higher consumptions of total fats, oleic acid, SAFAs, total PUFAs, trans fat, MUFAs, and linoleic acid are significantly associated with increased risk for UC; however, no statistically significant associations were detected between the risk of disease and n-3 PUFAs and cholesterol intake.
authors.affiliation: Department of Clinical Nutrition and Diet Therapy, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Sciences, 7 No, West Arghavan St., Farahzadi Blvd., 1981619573, 19395-4741, Tehran, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Rashvand
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Somi
authors.forename: Bahram
authors.initials: B
authors.lastname: Rashidkhani
authors.forename: Azita
authors.initials: A
authors.lastname: Hekmatdoost
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000453:epidemiology*; D004034:Diet Surveys; D004041:Dietary Fats / Q000008:administration & dosage*; D005227:Fatty Acids / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008297:Male; D019301:Oleic Acid / Q000008:administration & dosage; D012307:Risk Factors; D044242:Trans Fatty Acids / Q000008:administration & dosage
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D044242:Trans Fatty Acids; D019301:Oleic Acid