title: The human counterpart of mouse B-1 cells.
abstract: B-1 cells represent a subpopulation of B cells that has been extensively studied in mice and shown to spontaneously generate natural antibody that provides antimicrobial protection and helps dispose of cellular debris. Mouse B-1 cells originate from distinct progenitors and express additional immune properties that include phagocytosis, antigen presentation, immune suppression, and polarization of T cell differentiation. Confusion regarding the existence of human B-1 cells with mouse B-1-like properties has recently been addressed by identification of a new phenotypic profile. Human B-1 cells spontaneously secrete antibody and are distinct from other circulating B cell populations by multiple criteria. A number of laboratories have recently reported on changes to the human B-1 cell population in human disease.
authors.affiliation: Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, and the Hofstra North Shore-LIJ School of Medicine, Manhasset, New York.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Rothstein
authors.affiliation: Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, and the Hofstra North Shore-LIJ School of Medicine, Manhasset, New York.
authors.forename: Tam D
authors.initials: TD
authors.lastname: Quach
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*; D016026:Bone Marrow Transplantation / Q000639:trends; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology; D051379:Mice; D013045:Species Specificity
keywords: B cells; antibody; human; lymphocytes; phenotype