title: Spindle Cell Epithelioma of the Vagina: Report of Two Cases, Literature Review, and New Immunohistochemical Markers.
abstract: Spindle cell epitheliomas of the vagina are rare benign tumors of uncertain histogenesis. It has been hypothesized that they originate from a pluripotent cell population. Here, we report 2 cases of spindle cell epitheliomas of the vagina. Both patients presented with a painless vaginal nodule. The resected lesions were solid, well circumscribed, and composed of a proliferation of epithelioid or epithelial cells admixed with spindle cells without atypia. The 2 cellular populations expressed epithelial and mesenchymal markers. Based on these morphologic and immunohistochemical findings, a diagnosis of spindle cell epithelioma was rendered in both cases. Furthermore, we describe for the first time the expression of WT-1 (Wilms' tumor protein 1) and calretinin in addition to the previously defined immunohistochemical profile.
authors.affiliation: Department of pathology, Université de Montréal, CHUM, Montréal, Québec, Canada jeremie.berdugo@umontreal.ca.
authors.forename: Jérémie
authors.initials: J
authors.lastname: Berdugo
authors.affiliation: Department of gynecologic oncology, Université de Montréal, CHUM, Montréal, Québec, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Gauthier
authors.affiliation: Department of gynecologic oncology, Université de Montréal, CHUM, Montréal, Québec, Canada.
authors.forename: Diane
authors.initials: D
authors.lastname: Provencher
authors.affiliation: Université de Sherbrooke, Hôpital Charles-LeMoyne, Longueil, Québec, Canada.
authors.forename: Claire
authors.initials: C
authors.lastname: Matte
authors.affiliation: Hôpital Pierre-Boucher, Longueil, Québec, Canada.
authors.forename: Jean
authors.initials: J
authors.lastname: Piché
authors.affiliation: Department of pathology, Université de Montréal, CHUM, Montréal, Québec, Canada.
authors.forename: Kurosh
authors.initials: K
authors.lastname: Rahimi
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D014625:Vaginal Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: mixed tumor; spindle cell epithelioma; vagina