title: Biomechanical gait features associated with hip osteoarthritis: Towards a better definition of clinical hallmarks.
abstract: Critical appraisal of the literature highlights that the discriminative power of gait-related features in patients with hip osteoarthritis (OA) has not been fully explored. We aimed to reduce the number of gait-related features and define the most discriminative ones comparing the three-dimensional gait analysis of 20 patients with hip osteoarthritis (OA) with those of 17 healthy peers. First, principal component analysis was used to reduce the high-dimensional gait data into a reduced set of interpretable variables for further analysis, including tests for group differences. These differences were indicative for the selection of the top 10 variables to be included into linear discriminant analysis models (LDA). Our findings demonstrated the successful data reduction of hip osteoarthritic-related gait features with a high discriminatory power. The combination of the top variables into LDA models clearly separated groups, with a maximum misclassification error rate of 19%, estimated by cross-validation. Decreased hip/knee extension, hip flexion and internal rotation moment were gait features with the highest discriminatory power. This study listed the most clinically relevant gait features characteristics of hip OA. Moreover, it will help clinicians and physiotherapists understand the movement pathomechanics related to hip OA useful in the management and design of rehabilitation intervention.
authors.affiliation: Department of Rehabilitation Sciences, UZ Leuven, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium.|UZ Pellenberg Orthopedic Department, University Hospitals Leuven, Pellenberg, Belgium.|Laboratory for Clinical Motion Analysis (C-MAL), University Hospital Pellenberg, UZ Leuven, Belgium.
authors.forename: Christophe A G
authors.initials: CA
authors.lastname: Meyer
authors.affiliation: Orthopedic Association Genk, Ziekenhuis Oost-Limburg Genk, Belgium.
authors.forename: Kristoff
authors.initials: K
authors.lastname: Corten
authors.affiliation: I-Biostat, KU Leuven University and Universiteit Hasselt, Leuven, Belgium.
authors.forename: Steffen
authors.initials: S
authors.lastname: Fieuws
authors.affiliation: Department of Rehabilitation Sciences, UZ Leuven, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium.|Laboratory for Clinical Motion Analysis (C-MAL), University Hospital Pellenberg, UZ Leuven, Belgium.
authors.forename: Kevin
authors.initials: K
authors.lastname: Deschamps
authors.affiliation: Department of Mechanical Engineering, KU Leuven, Faculty of Engineering, Leuven, Belgium.
authors.forename: Davide
authors.initials: D
authors.lastname: Monari
authors.affiliation: Human Movement Biomechanics Research Group, KU Leuven, Leuven, Belgium.
authors.forename: Mariska
authors.initials: M
authors.lastname: Wesseling
authors.affiliation: UZ Pellenberg Orthopedic Department, University Hospitals Leuven, Pellenberg, Belgium.|Department of Development and Regeneration, KU Leuven, Faculty of Medicine, Leuven, Belgium.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Simon
authors.affiliation: Department of Rehabilitation Sciences, UZ Leuven, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium.|Laboratory for Clinical Motion Analysis (C-MAL), University Hospital Pellenberg, UZ Leuven, Belgium.
authors.forename: Kaat
authors.initials: K
authors.lastname: Desloovere
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena; D003430:Cross-Sectional Studies; D016002:Discriminant Analysis; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000175:diagnosis / Q000503:physiopathology*; D025341:Principal Component Analysis
keywords: discriminant analysis; gait; hip osteoarthritis; motion analysis; principal component analysis