title: Exposure to early adversity: Points of cross-species translation that can lead to improved understanding of depression.
abstract: The relationship between developmental exposure to adversity and affective disorders is reviewed. Adversity discussed herein includes physical and sexual abuse, neglect, or loss of a caregiver in humans. While these stressors can occur at any point during development, the unique temporal relationship to specific depressive symptoms was the focus of discussion. Further influences of stress exposure during sensitive periods can vary by gender and duration of abuse as well. Data from animal studies are presented to provide greater translational and causal understanding of how sensitive periods, different types of psychosocial stressors, and sex interact to produce depressive-like behaviors. Findings from maternal separation, isolation rearing, chronic variable stress, and peer-peer rearing paradigms clarify interpretation about how various depressive behaviors are influenced by age of exposure. Depressive behaviors are broken down into the following categories: mood and affect, anhedonia, energy, working memory, sleep-wake, appetite changes, suicide, and general malaise. Cross-species evidence from humans, nonhuman primates, rats, and mice within each of these categories is discussed. In conclusion, sensitive periods for affective-related behaviors (anxiety, mood, and controllability) occur earlier in life, while other aspects of depression are associated with adversity later during adolescence.
authors.affiliation: Harvard Medical School.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Andersen
mesh_terms: D000818:Animals; D001007:Anxiety / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D003863:Depression / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D003866:Depressive Disorder / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D008426:Maternal Deprivation; D051379:Mice; D051381:Rats