title: Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol.
abstract: A facile and efficient approach for the synthesis of a variety of acridines via the tandem coupling/cyclization of substituted 2-bromobenzaldehydes and anilines is described. The reaction can be accomplished with ease in the presence of a catalytic amount of Pd2(dba)3 and diphosphine ligand dppf, providing a broad range of substituted acridines in good to excellent yields (up to 99%). The Lewis acid, AlCl3, is required to promote the cyclization for less electron-rich anilines.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. xumh@simm.ac.cn.
authors.forename: Ting-Jun
authors.initials: TJ
authors.lastname: Wang
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Xu
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry; D001547:Benzaldehydes / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry
chemical_list: C000604288:2-bromobenzaldehyde; D000166:Acridines; D001547:Benzaldehydes; D010720:Phosphines; D010165:Palladium