title: The papez circuit in first-episode, treatment-naive adults with major depressive disorder: combined atlas-based tract-specific quantification analysis and voxel-based analysis.
abstract: Previous findings suggest that the Papez Circuit may have a role in major depressive disorders. We used atlas-based tract-specific quantification analysis and voxel-based analysis to examine the integrity of white matter tracts involved in mood regulation (including tracts in the Papez Circuit). Diffusion tensor imaging acquired from 35 first-episode, treatment-naive adults with major depressive disorders and 34 healthy adult controls were compared. Our statistical approach compared structural integrity of 11 major white matter tracts between the major depressive disorder and adult controls, as well as illness duration influence in patients. Fractional anisotropy was decreased in the hippocampal cingulum and in the anterior thalamic radiation according to both analytical approaches, all of which were important tracts included in the Papez Circuit. Our results support the role of the Papez Circuit in major depressive disorders with the minimal probability of false positive due to similar findings in both analyses that have complementary advantages. Dysfunction of the Papez Circuit may be a potential marker for studying the pathogenesis of major depressive disorders.
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China; Department of Radiology, The Liaoning Cancer Hospital & Institute, Shenyang 110042, Liaoning, PR China.
authors.forename: Wenyan
authors.initials: W
authors.lastname: Jiang
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, PR China.
authors.forename: Gaolang
authors.initials: G
authors.lastname: Gong
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Lingtao
authors.initials: L
authors.lastname: Kong
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Kaiyuan
authors.initials: K
authors.lastname: Chen
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Radiology, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Ling
authors.initials: L
authors.lastname: Ren
authors.affiliation: Department of Radiology, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Guoguang
authors.initials: G
authors.lastname: Fan
authors.affiliation: Department of Radiology, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Wenge
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Huan
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Radiology, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China.
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China; Department of Radiology, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, PR China; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America.
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000339:Affect; D017668:Age of Onset; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D066127:White Matter / Q000473:pathology* / Q000503:physiopathology*; D055815:Young Adult