title: Consensus on the development of vaccines against naturally acquired melioidosis.
abstract: Several candidates for a vaccine against Burkholderia pseudomallei, the causal bacterium of melioidosis, have been developed, and a rational approach is now needed to select and advance candidates for testing in relevant nonhuman primate models and in human clinical trials. Development of such a vaccine was the topic of a meeting in the United Kingdom in March 2014 attended by international candidate vaccine developers, researchers, and government health officials. The focus of the meeting was advancement of vaccines for prevention of natural infection, rather than for protection from the organism's known potential for use as a biological weapon. A direct comparison of candidate vaccines in well-characterized mouse models was proposed. Knowledge gaps requiring further research were identified. Recommendations were made to accelerate the development of an effective vaccine against melioidosis.
authors.forename: Direk
authors.initials: D
authors.lastname: Limmathurotsakul
authors.forename: Simon G P
authors.initials: SG
authors.lastname: Funnell
authors.forename: Alfredo G
authors.initials: AG
authors.lastname: Torres
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Morici
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Brett
authors.forename: Susanna
authors.initials: S
authors.lastname: Dunachie
authors.forename: Timothy
authors.initials: T
authors.lastname: Atkins
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Altmann
authors.forename: Gregory
authors.initials: G
authors.lastname: Bancroft
authors.forename: Sharon J
authors.initials: SJ
authors.lastname: Peacock
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000191:economics / Q000276:immunology*; D016957:Burkholderia pseudomallei / Q000276:immunology*; D002202:Capital Financing; D004195:Disease Models, Animal; D006801:Humans; D008554:Melioidosis / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control*; D051379:Mice
chemical_list: D001428:Bacterial Vaccines
keywords: Burkholderia pseudomallei; Steering Group on Melioidosis Vaccine Development; Whitmore’s disease; aerosol inhalation; antimicrobial drugs; bacteria; challenge dose; intranasal; intraperitoneal; intravenous; melioidosis; prevention; vaccine