title: Drug-induced movement disorders.
abstract: BACKGROUND
  Drug-induced movement disorders (DIMDs) can be elicited by several kinds of pharmaceutical agents. The major groups of offending drugs include antidepressants, antipsychotics, antiepileptics, antimicrobials, antiarrhythmics, mood stabilisers and gastrointestinal drugs among others.
  
  
  METHODS
  This paper reviews literature covering each movement disorder induced by commercially available pharmaceuticals. Considering the magnitude of the topic, only the most prominent examples of offending agents were reported in each paragraph paying a special attention to the brief description of the pathomechanism and therapeutic options if available.
  
  
  CONCLUSIONS
  As the treatment of some DIMDs is quite challenging, a preventive approach is preferable. Accordingly, the use of the offending agents should be strictly limited to appropriate indications and they should be applied in as low doses and as short duration as the patient's condition allows. As most of DIMDs are related to an unspecific adverse action of medications in the basal ganglia and the cerebellum, future research should focus on better characterisation of the neurochemical profile of the affected functional systems, in addition to the development of drugs with higher selectivity and better side-effect profile.
authors.affiliation: University of Szeged, Albert Szent-Györgyi Clinical Center, Department of Neurology, Faculty of Medicine , Semmelweis u. 6, H-6725 Szeged , Hungary +36 62 545351 ; +36 62 545597 ; vecsei.laszlo@med.u-szeged.hu.
authors.forename: Dénes
authors.initials: D
authors.lastname: Zádori
authors.forename: Gábor
authors.initials: G
authors.lastname: Veres
authors.forename: Levente
authors.initials: L
authors.lastname: Szalárdy
authors.forename: Péter
authors.initials: P
authors.lastname: Klivényi
authors.forename: László
authors.initials: L
authors.lastname: Vécsei
mesh_terms: D001479:Basal Ganglia / Q000187:drug effects; D002531:Cerebellum / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions / Q000503:physiopathology* / Q000517:prevention & control; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D006801:Humans; D009069:Movement Disorders / Q000209:etiology* / Q000503:physiopathology
keywords: basal ganglia; drug-induced side-effects; movement disorders; tardive syndromes