title: Therapeutic efficacy of biochanin A against arsenic-induced renal and cardiac damage in rats.
abstract: The present study was investigated the effects of biochanin A (BCA) on arsenic toxicity in rats. For this purpose, rats were orally treated with arsenic in the form of sodium meta-arsenite alone (10mg/kg body weight (bw)/day) and co-administered selenium (10mg/kgbw/day) and BCA at different doses (10, 20 and 40mg/kgbw/day) for 6 weeks. Arsenic altered the oxidative stress indices in both renal and cardiac tissues. There was an increase in plasma renal markers, triglyceride, lipoproteins with no alterations in cholesterol levels were noted in arsenic-intoxicated rats. Non-significant changes of phospholipids and free fatty acids levels in the tissues of arsenic-exposed rats. The biochemical disturbances were well correlated with the histological findings in the kidney, but not in the heart. The administration of BCA and selenium significantly reversed the alterations in the above-mentioned parameters in arsenic-intoxicated rats. Our findings revealed the beneficial effects of BCA against arsenic toxicity.
authors.affiliation: Department of Animal Biotechnology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Abdulkadhar Mohamed
authors.initials: AM
authors.lastname: Jalaludeen
authors.affiliation: Division of Food Bioscience, College of Biomedical and Health Science, Konkuk University, Chung-ju 380-701, Republic of Korea.
authors.forename: Won Young
authors.initials: WY
authors.lastname: Lee
authors.affiliation: Pourtry Science Division, National Institute of Animal Science, RDA, Seonghwan 331-808, Republic of Korea.
authors.forename: Ji Hyuk
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Dairy Science Division, National Institute of Animal Science, RDA, Seonghwan 331-808, Republic of Korea.
authors.forename: Ha Yeon
authors.initials: HY
authors.lastname: Jeong
authors.affiliation: Dairy Science Division, National Institute of Animal Science, RDA, Seonghwan 331-808, Republic of Korea.
authors.forename: Kwnag Seok
authors.initials: KS
authors.lastname: Ki
authors.affiliation: Dairy Science Division, National Institute of Animal Science, RDA, Seonghwan 331-808, Republic of Korea.
authors.forename: Eung Gi
authors.initials: EG
authors.lastname: Kwon
authors.affiliation: Department of Animal Biotechnology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea. Electronic address: songh@konkuk.ac.kr.
authors.forename: Hyuk
authors.initials: H
authors.lastname: Song
mesh_terms: D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D015415:Biomarkers / Q000032:analysis*; D004334:Drug Administration Schedule; D019833:Genistein / Q000008:administration & dosage* / Q000494:pharmacology; D006335:Heart Injuries / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D015415:Biomarkers; D019833:Genistein; D012643:Selenium; D001151:Arsenic; C004541:biochanin A
keywords: Arsenic; Biochanin A; Lipid peroxidation; Reactive oxygen species; Selenium