title: Microtubules, MAPs, and motor patterns.
abstract: Cells have an amazing ability to self-organize and rearrange their interiors. Such morphology changes are essential to cell development, division, and motility. The core of a cell's internal organization lies with the cytoskeleton made of both microtubule and actin filaments with their associated proteins and ATP-utilizing enzymes. Despite years of in vitro reconstitution experiments, we still do not fully understand how the cytoskeleton can self-organize. In an attempt to create a simple system of self-organization, we have used a simple filament-gliding assay to examine how kinesin-1-driven motion of microtubules can generate cell-like organization in the presence of excess filaments and antiparallel cross-linkers.
authors.affiliation: Molecular and Cellular Biology Graduate Program, Department of Physics, University of Massachusetts Amherst, Amherst, MA, USA.
authors.forename: Kasimira T
authors.initials: KT
authors.lastname: Stanhope
authors.affiliation: Molecular and Cellular Biology Graduate Program, Department of Physics, University of Massachusetts Amherst, Amherst, MA, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Ross
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism* / Q000502:physiology; D029681:Arabidopsis Proteins / Q000737:chemistry; D002465:Cell Movement / Q000502:physiology*; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D016547:Kinesins / Q000502:physiology; D007734:Kymography / Q000379:methods; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism* / Q000502:physiology; D008938:Mitosis / Q000502:physiology
chemical_list: D029681:Arabidopsis Proteins; C492901:MAP65-1 protein, Arabidopsis; D008869:Microtubule-Associated Proteins; D016547:Kinesins
keywords: Active matter; Kinesin-1; Microtubule-associate proteins; Motor proteins; Nonequilibrium; Pattern formation; Quantitative biology; Synthetic biophysics