title: Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery.
abstract: A stimuli-responsive drug delivery system based on fluorescent, lectin-gated, mesoporous glyconanoparticles has been developed and evaluated in normal- and cancer lung epithelial cells. The gating process proved efficient, exhibiting good sealing properties in the absence of the glutathione redox trigger, avoiding premature release in normal cells. In the presence of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the anticancer drug released.
authors.affiliation: Department of Chemistry, KTH - Royal Institute of Technology, Teknikringen 30, S-10044 Stockholm, Sweden. ramstrom@kth.se.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.forename: Nanjing
authors.initials: N
authors.lastname: Hao
authors.forename: Thareendra
authors.initials: T
authors.lastname: De Zoyza
authors.forename: Mingdi
authors.initials: M
authors.lastname: Yan
authors.forename: Olof
authors.initials: O
authors.lastname: Ramström
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D002460:Cell Line; D045744:Cell Line, Tumor; D003208:Concanavalin A / Q000737:chemistry* / Q000378:metabolism; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008358:Mannose / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D003208:Concanavalin A; D012822:Silicon Dioxide; D004317:Doxorubicin; D005978:Glutathione; D016650:Fluorescein-5-isothiocyanate; D008358:Mannose