title: Silks as scaffolds for skin reconstruction.
abstract: In this short review, we describe the use of high molecular weight proteins produced in the glands of several arthropods-commonly called silks-for the purpose to enhance human skin wound healing. To this end an extensive literature search has been performed, the publications have been categorized concerning silk preparation and application and summarized accordingly: Scaffolds to promote wound healing were prepared by processing the silks in different ways including solubilization of the protein fibers followed by casting or electrospinning. The silk scaffolds were additionally modified by coating or blending with the intention of further functionalization. In several approaches, the scaffolds were also vitalized with skin cells or stem cells. In vitro and in vivo models were implied to test for safety and efficiency. We conclude that silk scaffolds are characterized by an advantageous biocompatibility as well as an impressive versatility rendering them ideally suited for application in wounds. Nevertheless, further investigation is needed to exploit the full capacity of silk in different wound models and to achieve clinical transfer in time.
authors.affiliation: Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Podbielskistr. 380, 30659 Hannover, Germany. reimers.kerstin@mh-hannover.de.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Reimers
authors.affiliation: Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Podbielskistr. 380, 30659 Hannover, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Liebsch
authors.affiliation: Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Podbielskistr. 380, 30659 Hannover, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Radtke
authors.affiliation: Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Podbielskistr. 380, 30659 Hannover, Germany.
authors.forename: Jörn W
authors.initials: JW
authors.lastname: Kuhbier
authors.affiliation: Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Podbielskistr. 380, 30659 Hannover, Germany.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Vogt
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004195:Disease Models, Animal; D006801:Humans; D008954:Models, Biological; D047011:Silk; D012867:Skin / Q000254:growth & development*; D054457:Tissue Scaffolds; D014945:Wound Healing; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D001672:Biocompatible Materials; D047011:Silk
keywords: electrospinning; silk; skin replacement; wound healing