title: Overweight increases the risk of malignancy in patients with pancreatic mucinous cystic neoplasms.
abstract: Distinguishing between benign and malignant pancreatic cysts remains a clinical challenge. The aim of this study was to investigate the influence of body mass index (BMI) and preoperative clinical and cyst features, as described by the International Consensus Guidelines, on malignancy in patients with pancreatic mucinous cystic neoplasms (PMCNs).A retrospective cohort study was performed on patients with PMCNs who underwent surgical resection between January 1994 and June 2014. Preoperative BMI, clinical demographic data, cystic features, tumor markers, and surgical pathology results were analyzed. Predictors of malignancy were determined by univariate and multivariate analysis using logistic regression.One hundred sixty-four cases of PMCNs, including 106 intraductal papillary mucinous neoplasms (IPMNs) and 58 mucinous cystic neoplasms (MCNs), were analyzed. On univariate analysis, older age (P = 0.008), male sex (P = 0.007), high-risk stigmata (P = 0.007), diabetes mellitus (DM; P = 0.008), and BMI >25 (P < 0.001) were associated with malignancy. Multivariate analysis found that BMI >25 (odds ratio, 3.99; 95% confidence interval: 1.60-10) was an independent predictor of malignancy. In subgroup analysis, BMI >25 was an independent predictor of malignancy in IPMNs but not in MCNs.Overweight patients with IPMNs have a higher risk of malignancy and should be followed closely or undergo resection. The operative strategy for PMCNs should consider cyst-related and patient-related risk factors.
authors.affiliation: From the Departments of Internal Medicine (YTC, JMW, M-CC), Surgery (YWT, C-YY), Pathology (YMJ) and Medical Image (P-CL), National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Chang
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Tien
authors.forename: Yung-Ming
authors.initials: YM
authors.lastname: Jeng
authors.forename: Ching-Yao
authors.initials: CY
authors.lastname: Yang
authors.forename: Po-Chin
authors.initials: PC
authors.lastname: Liang
authors.forename: Jau-Min
authors.initials: JM
authors.lastname: Wong
authors.forename: Ming-Chu
authors.initials: MC
authors.lastname: Chang
mesh_terms: D000367:Age Factors; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D050177:Overweight / Q000150:complications*; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors