title: Elevated serum periostin is associated with liver stiffness and clinical outcome in biliary atresia.
abstract: OBJECTIVE
  To analyze serum periostin and liver stiffness in postoperative biliary atresia (BA).
  
  
  METHODS
  A total of 60 BA patients and 14 controls were enrolled. Serum periostin levels were analyzed by ELISA. Liver stiffness measurement was determined by transient elastography.
  
  
  RESULTS
  Biliary atresia patients had significantly higher periostin and liver stiffness values than controls. Serum periostin levels were remarkably increased in BA patients with jaundice compared to those without jaundice. Moreover, serum periostin was correlated with liver stiffness.
  
  
  CONCLUSIONS
  Serum periostin was associated with liver stiffness in BA. Thus, serum periostin has potential as a parameter reflecting the severity in BA.
authors.affiliation: Department of Biochemistry .
authors.forename: Sittisak
authors.initials: S
authors.lastname: Honsawek
authors.forename: Wanvisa
authors.initials: W
authors.lastname: Udomsinprasert
authors.forename: Paisarn
authors.initials: P
authors.lastname: Vejchapipat
authors.forename: Voranush
authors.initials: V
authors.lastname: Chongsrisawat
authors.forename: Nopaorn
authors.initials: N
authors.lastname: Phavichitr
authors.forename: Yong
authors.initials: Y
authors.lastname: Poovorawan
mesh_terms: D001656:Biliary Atresia / Q000097:blood* / Q000150:complications / Q000601:surgery; D015415:Biomarkers / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000097:blood*; D002648:Child; D054459:Elasticity Imaging Techniques; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007565:Jaundice / Q000097:blood / Q000150:complications; D008099:Liver / Q000473:pathology* / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D011184:Postoperative Period; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; C512835:POSTN protein, human
keywords: Biliary atresia; jaundice; liver stiffness; periostin; severity