title: Large-scale spatiotemporal spike patterning consistent with wave propagation in motor cortex.
abstract: Aggregate signals in cortex are known to be spatiotemporally organized as propagating waves across the cortical surface, but it remains unclear whether the same is true for spiking activity in individual neurons. Furthermore, the functional interactions between cortical neurons are well documented but their spatial arrangement on the cortical surface has been largely ignored. Here we use a functional network analysis to demonstrate that a subset of motor cortical neurons in non-human primates spatially coordinate their spiking activity in a manner that closely matches wave propagation measured in the beta oscillatory band of the local field potential. We also demonstrate that sequential spiking of pairs of neuron contains task-relevant information that peaks when the neurons are spatially oriented along the wave axis. We hypothesize that the spatial anisotropy of spike patterning may reflect the underlying organization of motor cortex and may be a general property shared by other cortical areas.
authors.affiliation: Department of Organismal Biology and Anatomy, University of Chicago, 1025 E 57th Street Culver Room 206, Chicago, Illinois 60637, USA.
authors.forename: Kazutaka
authors.identifier: 0000000176790430
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive MC 0412, San Diego, La Jolla, California, 92093, USA.
authors.forename: Sanggyun
authors.initials: S
authors.lastname: Kim
authors.affiliation: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive MC 0412, San Diego, La Jolla, California, 92093, USA.
authors.forename: Todd P
authors.initials: TP
authors.lastname: Coleman
authors.affiliation: Center for Neuroscience, New York University, 4 Washington Place, New York City, New York 10003, USA.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Brown
authors.affiliation: Department Electrical Engineering and Computer Science, Milwaukee School of Engineering, 1025 N Broadway, Milwaukee, Wisconsin 53202, USA.
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Suminski
authors.affiliation: Committee on Computational Neuroscience, University of Chicago, 1025 E 57th Street Culver Room 206, Chicago, Illinois 60637, USA.
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Best
authors.affiliation: 1] Department of Organismal Biology and Anatomy, University of Chicago, 1025 E 57th Street Culver Room 206, Chicago, Illinois 60637, USA [2] Committee on Computational Neuroscience, University of Chicago, 1025 E 57th Street Culver Room 206, Chicago, Illinois 60637, USA.
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Hatsopoulos
mesh_terms: D000200:Action Potentials; D000818:Animals; D016880:Anisotropy; D008253:Macaca mulatta; D008297:Male; D009044:Motor Cortex / Q000378:metabolism*; D009415:Nerve Net; D009474:Neurons / Q000145:classification / Q000378:metabolism