title: IgG "detoxes" the intestinal mucosa.
abstract: Secretory IgA is important in mucosal defense, but other, incompletely understood effectors exist. In this issue of Cell Host & Microbe, Kamada et al. (2015) show that IgG antibodies are produced against surface virulence factors of an intestinal attaching/effacing pathogen, bind to bacteria localized at the epithelium, and direct their destruction by mucosal and translocated neutrophils.
authors.affiliation: Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: leckmann@ucsd.edu.
authors.forename: Lars
authors.initials: L
authors.lastname: Eckmann
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Thaddeus S
authors.initials: TS
authors.lastname: Stappenbeck
mesh_terms: D000818:Animals; D044082:Citrobacter rodentium / Q000254:growth & development* / Q000276:immunology*; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D056724:Immunity, Humoral; D037521:Virulence Factors / Q000276:immunology* / Q000378:metabolism*
chemical_list: D037521:Virulence Factors