title: Subtype-dependent Morphological and Functional Degeneration of Retinal Ganglion Cells in Mouse Models of Experimental Glaucoma.
abstract: In this short review, Puyang and her colleagues compared the results from three laboratories on the dendritic and functional degeneration of retinal ganglion cells (RGCs) in mouse models of experimental glaucoma [1-4]. Acute or chronic ocular hypertension was induced in mice, and different techniques were applied to identify RGC types. The dendritic alternations of RGCs were examined following the induction of ocular hypertension, and their light response properties were characterized by the multi-electrode array (MEA) recording. These studies support the notion that the morphological and functional degeneration of RGCs are subtype-dependent in experimental glaucoma.
authors.affiliation: Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA ; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Puyang
authors.affiliation: Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA ; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, Illinois 60208, USA.
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Liu
keywords: Dendritic Degeneration; Experimental Glaucoma; Multi-Electrode Array (MEA); Retinal Ganglion Cells (RGCs)