title: Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature.
abstract: It is currently recognized that the pathogenesis of malignancy-associated thrombotic microangiopathy (TMA) is distinct from thrombotic thrombocytopenic purpura. This carries important implications in its classification and its management. Here, we report a case of occult malignancy presenting initially as acute kidney injury secondary to TMA and highlight the importance of considering an underlying malignancy in patients not responding to conventional therapy for TMA.
authors.affiliation: Division of Nephrology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.
authors.forename: Simon A
authors.initials: SA
authors.lastname: Houston
authors.affiliation: Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Hegele
authors.affiliation: Department of Pathology, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Canada.
authors.forename: Linda
authors.initials: L
authors.lastname: Sugar
authors.affiliation: Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada.
authors.forename: Errol
authors.initials: E
authors.lastname: Colak
authors.affiliation: Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.
authors.forename: Katerina
authors.initials: K
authors.lastname: Pavenski
authors.affiliation: Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.
authors.forename: Ghassan
authors.initials: G
authors.lastname: Allo
authors.affiliation: Division of Nephrology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Perl
keywords: malignancy; microangiopathy; plasma exchange; thromobotic