title: Bladder function in obstructed men - does age matter?
abstract: OBJECTIVE
  The high prevalence of diseases and disabilities in the elderly will therefore impose major future challenges for governments, particularly in social security, health system and social care.
  
  
  METHODS
  Nine hundred and seventy-one men, 40 years or older referred for low urinary tract symptoms (LUTS) evaluation who underwent full urodynamic investigation, were reviewed. Urodynamic parameters were obtained, such as Uroflowmetry, those of Filling Cystometry and those of pressure flow study (PFS).
  
  
  RESULTS
  Mean age was of 66.1 years old. Most the patients included in the analysis were categorized as Schafer score 2-4. Correlation analysis of uroflowmetry parameters revealed statistically significant decrease in voided volume (p = 0.013), Qmax (p = 0.023) with aging. Cystometric parameters revealed significant age-related decrease in bladder capacity (p < 0.001) and bladder compliance (p = 0.004). PFS revealed significant decrease in voiding efficiency (p = 0.029), voided volume (p < 0.001), Qave (p = 0.008) and Qmax (p = 0.048) with progressing age. Age subgroup analyses showed significant differences in voiding efficiency (KW, p = 0.032), voided volume (KW, p < 0.001) and Qave (KW, p = 0.036).
  
  
  CONCLUSIONS
  Age-related changes in voiding function might not be a result of impaired detrusor contractility or increased outflow obstruction, intrinsic causes must be suspected. Changes in the storage function of the bladder represent specific pathophysiological mechanisms influenced by aging.
authors.forename: Fabricio
authors.initials: F
authors.lastname: Beltrame
authors.affiliation: a Division of Geriatric Urology , Federal University of São Paulo , Brazil .
authors.forename: Fabrizzio
authors.initials: F
authors.lastname: Beltrame
authors.affiliation: b Department of Surgery , State Campinas University , Campinas , SP , Brazil .
authors.forename: Fabio Thadeu
authors.initials: FT
authors.lastname: Ferreira
authors.affiliation: c Division of Geriatric Urology, Escola Paulista de Medicina , Federal University of São Paulo , São Paulo , Brazil .
authors.forename: Fabio
authors.initials: F
authors.lastname: Lorenzetti
authors.affiliation: d Faculty of Medicine , São Leopoldo Mandic , Campinas, São Paulo , Brazil , and.
authors.forename: Mara
authors.initials: M
authors.lastname: Dambros
authors.affiliation: d Faculty of Medicine , São Leopoldo Mandic , Campinas, São Paulo , Brazil , and.
authors.forename: Sergio
authors.initials: S
authors.lastname: Bisogni
authors.affiliation: e Hospital Municipal Dr. Mario Gatti , Campinas , Brazil.
authors.forename: Miriam
authors.initials: M
authors.lastname: Dambros
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000503:physiopathology; D014517:Ureteral Obstruction; D001743:Urinary Bladder / Q000502:physiology*; D014563:Urodynamics
keywords: Aging; prostate; urinary bladder neck obstruction; urodynamic