title: Neural targets in the study and treatment of social cognition in autism spectrum disorder.
abstract: The purpose of this chapter is to present results from recent research on social cognition in autism spectrum disorder (ASD). The clinical phenomenology and neuroanatomical circuitry of ASD are first briefly described. The neuropharmacology of social cognition in animal models of ASD and humans is then addressed. Next, preclinical and clinical research on the neurohormone oxytocin is reviewed. This is followed by a presentation of results from preclinical and clinical studies on the excitatory amino acid glutamate. Finally, the role of neuroinflammation in ASD is addressed from the perspectives of preclinical neuroscience and research involving humans with ASD.
authors.affiliation: Massachusetts General Hospital, 02114, Boston, MA, USA.
authors.forename: Arshya
authors.initials: A
authors.lastname: Vahabzadeh
authors.forename: Samantha M
authors.initials: SM
authors.lastname: Landino
authors.forename: Beate C
authors.initials: BC
authors.lastname: Finger
authors.forename: William A
authors.initials: WA
authors.lastname: Carlezon
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: McDougle
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D002659:Child Development Disorders, Pervasive / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D003071:Cognition / Q000187:drug effects*; D004195:Disease Models, Animal; D006801:Humans; D007398:Interpersonal Relations; D009434:Neural Pathways / Q000187:drug effects / Q000503:physiopathology; D018697:Nootropic Agents / Q000627:therapeutic use*; D012919:Social Behavior
chemical_list: D018697:Nootropic Agents