title: Folic acid conjugated ferritins as photosensitizer carriers for photodynamic therapy.
abstract: We coupled folic acid as a tumour targeting ligand to the surface of ferritins and loaded them with ZnF16Pc. The resulting nanoconjugates can efficiently hone in on 4T1 tumours in vivo, and, with photoirradiation, leading to suppressed tumour growth and tumour metastasis.
authors.affiliation: Department of Chemistry, University of Georgia, Athens, Georgia 30602, USA.
authors.forename: Zipeng
authors.initials: Z
authors.lastname: Zhen
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Weizhong
authors.initials: W
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Xie
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005293:Ferritins / Q000737:chemistry / Q000493:pharmacokinetics*; D005492:Folic Acid; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D058726:Nanoconjugates / Q000737:chemistry / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D053769:Nanocapsules; D058726:Nanoconjugates; D017319:Photosensitizing Agents; D005293:Ferritins; D005492:Folic Acid