title: Multistep microsatellite mutation leading to father-child mismatch of FGA locus in a case of non-exclusion parentage.
abstract: A non-exclusion paternity case with a mismatch in the autosomal short tandem repeats (STR) locus FGA is reported. The genotypes of the suspected father, the mother and the questioned child in FGA locus were 18/25, 20/26 and 20/22, respectively. Examination of 38 autosomal STR loci revealed no mismatches, and the paternity index is up to 1.3618×10(6). The haplotype of 16 Y chromosomal STR in the child matched completely with that of the father. These results suggested that the suspected father is the biological father of the child and that a rare three- or four-step microsatellite mutation had occurred in the paternal allele of FGA.
authors.affiliation: Department of Forensic Medicine of Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China.
authors.forename: Yun Shu
authors.initials: YS
authors.lastname: Jia
authors.affiliation: AGCU ScienTech Incorporation, Wuxi 214174, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: AGCU ScienTech Incorporation, Wuxi 214174, China.
authors.forename: Li Yuan
authors.initials: LY
authors.lastname: Qi
authors.affiliation: Department of Forensic Medicine of Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Mei
authors.affiliation: Department of Forensic Medicine of Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China.
authors.forename: Feng Lei
authors.initials: FL
authors.lastname: Zhou
authors.affiliation: Department of Forensic Medicine of Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China.
authors.forename: Dai Xin
authors.initials: DX
authors.lastname: Huang
authors.affiliation: Department of Forensic Medicine of Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China. Electronic address: yishaoxia@126.com.
authors.forename: Shao Hua
authors.initials: SH
authors.lastname: Yi
mesh_terms: D002648:Child; D041322:Chromosomes, Human, Y; D005260:Female; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D009154:Mutation; D010334:Paternity
keywords: FGA; Multistep mutation; Paternity testing; STR