title: Toward organometallic antischistosomal drug candidates.
abstract: In the recent years, there has been a growing interest in the use of novel approaches for the treatment of parasitic diseases such as schistosomiasis. Among the different approaches used, organometallic compounds were found to offer unique opportunities in the design of antiparasitic drug candidates. A ferrocenyl derivative, namely ferroquine, has even entered clinical trials as a novel antimalarial. In this short review, we report on the studies describing the use of organometallic compounds against schistosomiasis.
authors.affiliation: Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
authors.forename: Jeannine
authors.initials: J
authors.lastname: Hess
authors.forename: Jennifer
authors.initials: J
authors.lastname: Keiser
authors.forename: Gilles
authors.initials: G
authors.lastname: Gasser
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D058492:Drug Repositioning; D006801:Humans; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D011223:Praziquantel / Q000031:analogs & derivatives / Q000494:pharmacology; D012547:Schistosoma / Q000187:drug effects*; D012552:Schistosomiasis / Q000188:drug therapy* / Q000469:parasitology; D012556:Schistosomicides / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D000962:Antimalarials; D009942:Organometallic Compounds; D012556:Schistosomicides; D011223:Praziquantel