title: [Serotonin and dopamine brain metabolism in mice with different predisposition to catalepsy].
abstract: Catalepsy usually is caused by imbalance of dopamine (DA) and serotonin (5-HT) systems of brain. The aim of our work was to verify if this imbalance plays an important role in the mechanism of hereditary catalepsy in mice. Maintenance of DA, 5-HT and their main metabolites--5-hydroxyindoleacetic acid, 3,4-dihydroxyphenylacetic acid, homovanilic acid was determined in cortex, hypothalamus, hippocampus, striatum, substantia nigra and nuclei raphes in catalepsy-resistant AKR/J mice strain and catalepsy-prone CBA/LacJ mice strain and recombinant mice AKR/J.CBA-D13Mit76 (D13) strain. The latest strain was selected by transferring of a fragment of the chromosome 13 from CBA/LacJ carrying the main gene of hereditary catalepsy to AKR/J genome. There were no interstrain differences in concentration of biogenic amines and their metabolites in all brain regions. As a result of our work the hypothesis about the important role of 5-HT and/or DA systems of brain in the mechanism of hereditary catalepsy in mice was denied.
authors.forename: N A
authors.initials: NA
authors.lastname: Sinyakova
authors.forename: E A
authors.initials: EA
authors.lastname: Kulikova
authors.forename: A V
authors.initials: AV
authors.lastname: Kulikov
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism*; D000818:Animals; D002375:Catalepsy / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000378:metabolism / Q000503:physiopathology; D003342:Corpus Striatum / Q000378:metabolism / Q000503:physiopathology; D003433:Crosses, Genetic; D004298:Dopamine / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D006719:Homovanillic Acid / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D009714:Nucleus Accumbens / Q000378:metabolism / Q000503:physiopathology; D065846:Nucleus Raphe Magnus / Q000378:metabolism / Q000503:physiopathology; D012701:Serotonin / Q000378:metabolism*; D013378:Substantia Nigra / Q000378:metabolism / Q000503:physiopathology
chemical_list: D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid