title: A biochemical and immunohistochemical study of the protective effects of carnosine for carbon tetrachloride induced liver injury in rats.
abstract: We investigated the protective effect of carnosine on carbon tetrachloride-induced liver tissue damage. Thirty-two adult male rats were divided into four equal groups. Group 1 was the untreated control, group 2 was injected with 0.2 ml/kg/day carbon tetrachloride, group 3 was injected with with 0.2 ml/kg/day carbon tetrachloride plus 200 mg/kg/day carnosine, and group 4 was injected with 200 mg/kg/day carnosine. Increased serum alanine amino transferase and aspartate amino transferase levels, liver malondialdehyde levels, HSP-70 expression and steatosis were observed following treatment with carbon tetrachloride. Carbon tetrachloride caused severe biochemical and histopathological changes in liver tissue and treatment with carnosine partially prevented the damage. HSP-70 may help control liver damage.
authors.affiliation: a Department of Histology and Embryology , Faculty of Medicine, Erciyes University , Kayseri , Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Kuloglu
authors.affiliation: a Department of Histology and Embryology , Faculty of Medicine, Erciyes University , Kayseri , Turkey.
authors.forename: M F
authors.initials: MF
authors.lastname: Sönmez
mesh_terms: D000417:Albinism; D000818:Animals; D000975:Antioxidants; D002251:Carbon Tetrachloride; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology* / Q000517:prevention & control*; D002336:Carnosine / Q000008:administration & dosage*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology* / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D002336:Carnosine; D002251:Carbon Tetrachloride
keywords: HSP-70; carbon tetrachloride; carnosine; liver; rat