title: [Preparation of hydrophilic matrix sustained release tablets of total lactones from Andrographis paniculata and study on its in vitro release mechanism].
abstract: In this study, hydrophilic matrix sustained release tablets of total lactones from Andrographis paniculata were prepared and the in vitro release behavior were also evaluated. The optimal prescription was achieved by studying the main factor of the type and amount of hydroxypropyl methylcellulose (HPMC) using single factor test and evaluating through cumulative release of three lactones. No burst drug release from the obtained matrix tablets was observed. Drug release sustained to 14 h. The release mechanism of three lactones from A. paniculata was accessed by zero-order, first-order, Higuchi and Peppas equation. The release behavior of total lactones from A. paniculata was better agreed with Higuchi model and the drug release from the tablets was controlled by degradation of the matrix. The preparation of hydrophilic matrix sustained release tablets of total lactones from A. paniculata with good performance of drug release was simple.
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Qing-Ming
authors.initials: QM
authors.lastname: Guo
authors.lastname: Wang Zhen-Zhong
authors.forename: Yu-An
authors.initials: YA
authors.lastname: Bi
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D035685:Andrographis / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D007783:Lactones / Q000737:chemistry*; D013607:Tablets / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D007783:Lactones; D013607:Tablets