title: Methods for delivering and evaluating the efficacy of cognitive enhancement.
abstract: Cognitive deficits are related to impaired everyday functioning in multiple conditions and in healthy individuals. Treatment of cognitive functioning can be facilitated through either pharmacological or remediation strategies. The critical goals of cognitive enhancement are to improve everyday functioning in multiple domains. This chapter describes the strategies that are most desirable for the treatment of cognitive impairments and detection of potential benefits of treatment in cognitive and functional domains. These strategies include the use of performance-based assessments of cognition and functioning and the appropriate use of observational strategies to detect changes. Finally, we define several outcome-related goals and discuss the practicality of their measurement.
authors.affiliation: University of Miami Miller School of Medicine, 1120 NW 14th Street, Suite 1450, Miami, FL, 33136, USA, pharvey@med.miami.edu.
authors.forename: Philip D
authors.initials: PD
authors.lastname: Harvey
authors.forename: Richard S E
authors.initials: RS
authors.lastname: Keefe
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D015928:Cognitive Behavioral Therapy / Q000379:methods; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D016896:Treatment Outcome
chemical_list: D018697:Nootropic Agents