title: Recurrence of herpes simplex encephalitis associated with temozolomide chemoradiation for malignant glioma: a case report and review of the literature.
abstract: Although herpes simplex encephalitis is not classically considered an opportunistic infection, reactivation of herpes simplex is being seen increasingly in patients with cancer or immunosuppression. The authors present a patient with malignant glioma and HSV-1 encephalitis whose PCR-proven encephalitis recurred after temozolomide (TMZ) chemoradiation despite acyclovir therapy, and summarize details of four other cases of HSV-1 encephalitis associated with TMZ. The similarity among these cases raises the likely need for longer treatment courses and/or oral suppressive therapy in patients at risk for herpes simplex infections who are receiving TMZ.
authors.affiliation: Harvard Medical School , Boston, MA , USA.
authors.forename: Mitalee P
authors.initials: MP
authors.lastname: Christman
authors.affiliation: Division of Infectious Diseases , Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Turbett
authors.affiliation: Department of Neurology , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA , USA.
authors.forename: Soma
authors.initials: S
authors.lastname: Sengupta
authors.affiliation: Department of Neurology , Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Khamidulla U
authors.initials: KU
authors.lastname: Bakhadirov
authors.affiliation: Department of Neurosurgery , University of Michigan , Ann Arbor, MI , USA.
authors.forename: Craig A
authors.initials: CA
authors.lastname: Williamson
authors.affiliation: Center for Neuro-Oncology , Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA , USA.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Nayak
authors.affiliation: Department of Neurology , Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Tracey
authors.initials: T
authors.lastname: Milligan
authors.affiliation: Division of Infectious Diseases , Brigham and Women's Hospital, Harvard Medical School , Boston, MA , USA.
authors.forename: Joel T
authors.initials: JT
authors.lastname: Katz