title: Prevalence of Eosinophilic Gastritis, Gastroenteritis, and Colitis: Estimates From a National Administrative Database.
abstract: OBJECTIVE
  Eosinophilic esophagitis (EoE) is becoming increasingly more common, but the prevalence of other eosinophilic gastrointestinal disorders (EGIDs) is unknown. Our objective was to estimate the prevalence of eosinophilic gastritis, gastroenteritis, and colitis in the United States.
  
  
  METHODS
  We used the IMS Health LifeLink PharMetrics Plus Claims Database, data representative of a US national commercially insured population containing medical and pharmaceutical claims for > 75 million individuals. We restricted our sample to patients ages 0 to 64 with continuous enrollment between July 1, 2009, and June 30, 2011. We identified patients with eosinophilic gastritis, gastroenteritis, and colitis as defined by ≥ 1 instance of the International Classification of Diseases, Ninth Revision codes 535.70, 558.41, and 558.42, respectively. We calculated the prevalence of the codes in the database and then standardized the estimates to the US population by age and sex.
  
  
  RESULTS
  The standardized estimated prevalences of eosinophilic gastritis, gastroenteritis, and colitis were 6.3/100,000, 8.4/100,000, and 3.3/100,000, respectively. The prevalence of eosinophilic gastroenteritis was the highest among children age < 5 years, whereas eosinophilic gastritis was more prevalent among older age groups. We observed no age differences for eosinophilic colitis. Among affected patients, there was a high proportion of coexisting allergic conditions, 38.5% for eosinophilic gastritis, 45.6% for gastroenteritis, and 41.8% for colitis. Concomitant allergic disease was most commonly identified in pediatric patients.
  
  
  CONCLUSIONS
  The prevalence of non-EoE EGIDs remains rare in the United States, with < 50,000 total patients affected. There appears to be a female predominance and a high co-occurrence of atopic comorbidities.
authors.affiliation: *Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine †Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine ‡Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill.
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Jensen
authors.forename: Christopher F
authors.initials: CF
authors.lastname: Martin
authors.forename: Michael D
authors.initials: MD
authors.lastname: Kappelman
authors.forename: Evan S
authors.initials: ES
authors.lastname: Dellon
mesh_terms: D000067575:Administrative Claims, Healthcare / Q000706:statistics & numerical data; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003092:Colitis / Q000453:epidemiology*; D015897:Comorbidity; D016208:Databases, Factual; D004751:Enteritis / Q000453:epidemiology*; D004802:Eosinophilia / Q000453:epidemiology*; D005260:Female; D005756:Gastritis / Q000453:epidemiology*; D005759:Gastroenteritis / Q000453:epidemiology*; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D038801:International Classification of Diseases; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology; D055815:Young Adult