title: Remarkably increased resistin levels in anti-AChR antibody-positive myasthenia gravis.
abstract: Resistin is a pro-inflammatory cytokine involved in the pathogenesis of autoimmune diseases. To investigate serum resistin levels in patients with myasthenia gravis (MG) and determine if there are associations between resistin levels and disease severity, we measured serum resistin levels in 102 patients with anti-acetylcholine receptor antibody-positive MG (AChR-MG). We further analyzed associations between serum resistin levels and clinical variables in patients with MG. Our findings demonstrate that serum resistin levels are elevated in patients with AChR-generalized MG and AChR-MG with thymoma and are correlated with disease severity. Resistin has potential as a useful serum biomarker for inflammation in AChR-MG.
authors.affiliation: Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Da-Qi
authors.initials: DQ
authors.lastname: Zhang
authors.affiliation: School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Qi
authors.affiliation: Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China. Electronic address: yangli2001@tijmu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood* / Q000145:classification / Q000209:etiology / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology*; D052243:Resistin / Q000097:blood*; D012720:Severity of Illness Index; D013945:Thymoma / Q000097:blood* / Q000150:complications; D013953:Thymus Neoplasms / Q000097:blood* / Q000150:complications; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; C499624:RETN protein, human; D011950:Receptors, Cholinergic; D052243:Resistin
keywords: Anti-acetylcholine receptor antibody; Myasthenia gravis; Resistin