title: The role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting.
abstract: Understanding the molecular mechanisms of the regulation of cell cycle is a central issue in molecular cell biology, due to its fundamental role in the existence of cells. The regulatory circuits that make decisions on when a cell should divide are very complex and particularly subtly balanced in eukaryotes, in which the harmony of many different cells in an organism is essential for life. Several hundred proteins are involved in these processes, and a great deal of studies attests that most of them have functionally relevant intrinsic structural disorder. Structural disorder imparts many functional advantages on these proteins, and we discuss it in detail that it is involved in all key steps from signaling through the cell membrane to regulating transcription of proteins that execute timely responses to an ever-changing environment.
authors.affiliation: Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, Budapest, Hungary.
authors.forename: Agnes
authors.initials: A
authors.lastname: Tantos
authors.forename: Lajos
authors.initials: L
authors.lastname: Kalmar
authors.forename: Peter
authors.initials: P
authors.lastname: Tompa
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints; D022082:Cellular Structures / Q000378:metabolism*; D015510:Clinical Medicine; D004194:Disease; D016503:Drug Delivery Systems; D006801:Humans; D040901:Proteomics; D015398:Signal Transduction
keywords: cancer; cell-cycle; checkpoint; post-translational modification; protein disorder; signal transduction