title: The Potential of Cr3 [Triaqua-μ3 -Oxo-Hexa-μ-Propionatotrichromium(III) Chloride] to Reduce Birth Defects in the Offspring of Diabetic CD-1 Mice.
abstract: Diabetes mellitus is a growing concern worldwide and leads to multiple complications during pregnancy. Pharmacologic doses of chromium (Cr) have been linked with improving insulin sensitivity and other positive benefits in the treatment of diabetes in animal models. By using streptozotocin induced hyperglycemia in female CD-1 mice, reproductive outcomes of diabetic and chromium-dosed diabetic females were examined. After dosing 10 mg/kg Cr in the form of triaqua-μ3 -oxo-hexa-μ-propionatotrichromium(III) chloride or Cr3 during gestation days 8-16 (GD8-GD16), all females were sacrificed on gestation day 17 (GD17) and examined for maternal weight gain. The fetuses were examined for gross malformations and for skeletal malformations. The offspring of Cr3-dosed females tended to have a reduction in the incidence of supernumerary ribs. While hyperglycemia still had negative impacts on the health of dams and their offspring, administration of Cr led to an apparent trend in the reduction in the number of malformations and incidence of supernumerary ribs compared to those of untreated diabetic mothers.
authors.affiliation: Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama.
authors.forename: Johnathan D
authors.initials: JD
authors.lastname: Keith
authors.affiliation: Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama.
authors.forename: Christina
authors.initials: C
authors.lastname: Vincent
authors.affiliation: Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama.
authors.forename: Michael
authors.initials: M
authors.lastname: Goetsch
authors.affiliation: Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama.
authors.forename: Amie
authors.initials: A
authors.lastname: Lemley
authors.affiliation: Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama.
authors.forename: Riley
authors.initials: R
authors.lastname: Kraus
authors.affiliation: Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama.
authors.forename: Austin
authors.initials: A
authors.lastname: Broussard
authors.affiliation: Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama.
authors.forename: Ashley
authors.initials: A
authors.lastname: Kildow
authors.affiliation: Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama.
authors.forename: Josh
authors.initials: J
authors.lastname: Faught
authors.affiliation: Department of Chemistry, The University of Alabama, Tuscaloosa, Alabama.
authors.forename: John B
authors.initials: JB
authors.lastname: Vincent
authors.affiliation: Department of Biological Sciences, The University of Alabama, Tuscaloosa, Alabama.
authors.forename: Jane F
authors.initials: JF
authors.lastname: Rasco
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D000013:Congenital Abnormalities / Q000209:etiology / Q000517:prevention & control*; D048909:Diabetes Complications / Q000209:etiology / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D047109:Fetal Development / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects / Q000473:pathology; D007328:Insulin / Q000378:metabolism; D008297:Male; D018811:Maternal Exposure; D051379:Mice; D009942:Organometallic Compounds / Q000494:pharmacology*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy* / Q000473:pathology
chemical_list: D001786:Blood Glucose; D007328:Insulin; D009942:Organometallic Compounds; C403535:triaquaoxohexakis(propionato)trichromium(III)
keywords: chromium; developmental toxicity; diabetes mellitus; mice