title: [New opportunities in the diagnosis of ulcerative colitis].
abstract: OBJECTIVE
  to analyze the expression of markers of apoptosis and proliferation in patients with ulcerative colitis.
  
  
  METHODS
  in 80 patients with ulcerative colitis the analysis of expression of apoptosis marker BAX and proliferation marker Ki-67, as well as the cell cycle regulator p53 in biopsy materials of the mucous membrane of the colon was carried out.
  
  
  RESULTS
  decreased cell proliferative activity and increase of the apoptosis rate depending on the severity, the localization of the inflammatory process and its endoscopic activity were registered.
authors.forename: A A
authors.initials: AA
authors.lastname: Markova
authors.forename: E I
authors.initials: EI
authors.lastname: Kashkina
authors.forename: G N
authors.initials: GN
authors.lastname: Maslyakova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017209:Apoptosis; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D049109:Cell Proliferation; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D051028:bcl-2-Associated X Protein / Q000096:biosynthesis*
chemical_list: C494826:BAX protein, human; D015415:Biomarkers; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D051028:bcl-2-Associated X Protein