title: Consensus of German transplant centers on hematopoietic stem cell transplantation in Fanconi anemia.
abstract: Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative therapy for the severe hematopoietic complications associated with Fanconi anemia (FA). In Germany, it is estimated that 10-15 transplants are performed annually for FA. However, because FA is a DNA repair disorder, standard conditioning regimens confer a high risk of excessive regimen-related toxicities and mortality, and reduced intensity regimens are linked with graft failure in some FA patients. Moreover, development of graft-versus-host disease is a major contributing factor for secondary solid tumors. The relative rarity of the disorder limits HSCT experience at any single center. Consensus meetings were convened to develop a national approach for HSCT in FA. This manuscript outlines current experience and knowledge about HSCT in FA and, based on this analysis, general recommendations reached at these meetings.
authors.affiliation: Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany.
authors.forename: M M
authors.initials: MM
authors.lastname: Chao
authors.affiliation: Pediatric Hematology/Oncology and Stem Cell Transplantation, Charité University Medicine Berlin, Berlin, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Ebell
authors.affiliation: Zentrum für Kinder- und Jugendmedizin, Klinikum der Johann-Wolfgang-Goethe-Universität, Klinik III, Frankfurt, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Bader
authors.affiliation: Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Beier
authors.affiliation: Pediatric Hematology/Oncology, University of Muenster, Muenster, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Burkhardt
authors.affiliation: Pediatric hematology/Oncology, University Children's Hospital Tuebingen, Tuebingen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Feuchtinger
authors.affiliation: Pediatric hematology/Oncology, University Children's Hospital Tuebingen, Tuebingen, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Handgretinger
authors.affiliation: Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: H
authors.initials: H
authors.lastname: Hanenberg
authors.affiliation: Institute of Cellular Therapeutics, Hannover Medical School, GMP-DU, IFB-Tx, Hannover, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Koehl
authors.affiliation: Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Kratz
authors.affiliation: Paediatric Hematology and Oncology, Medical Center, University of Essen, Essen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Kremens
authors.affiliation: Pediatric hematology/Oncology, University Children's Hospital Tuebingen, Tuebingen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Lang
authors.affiliation: Department of Pediatric Hematology Oncology, University of Düsseldorf Medical School, Düsseldorf, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Meisel
authors.affiliation: Pediatric Hematologie/Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Mueller
authors.affiliation: Pediatric Hematology/Oncology, University of Muenster, Muenster, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Roessig
authors.affiliation: Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Sauer
authors.affiliation: Childrens Hospitals, University of Würzburg, Germany.
authors.forename: P G
authors.initials: PG
authors.lastname: Schlegel
authors.affiliation: Univ.-Klinik für Kinder- und Jugendmedizin, Ulm, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Schulz
authors.affiliation: Pediatric Hematology and Oncology, University Freiburg, Freiburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Strahm
authors.affiliation: Hematology/Onkology, Hannover Medical School, Hannover, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Thol
authors.affiliation: Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany.
authors.forename: K W
authors.initials: KW
authors.lastname: Sykora
mesh_terms: D002648:Child; D036101:Cord Blood Stem Cell Transplantation; D005199:Fanconi Anemia / Q000097:blood / Q000628:therapy*; D005858:Germany; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000517:prevention & control; D019983:Guideline Adherence; D018380:Hematopoietic Stem Cell Transplantation; D006782:Hospitals, Special; D006801:Humans; D007165:Immunosuppression Therapy; D012189:Retrospective Studies; D012307:Risk Factors; D019172:Transplantation Conditioning