title: Population pharmacokinetics of levofloxacin in Korean patients.
abstract: Levofloxacin (LVFX) has different effects depending on the area under the concentration-time curve (AUC)/minimum inhibitory concentration (MIC) ratio. While AUC can be expressed as dose/clearance (CL), we measured serial concentrations of LVFX in Koreans and tried to set a Korean-specific equation, estimating the CL of the antibiotic. In total, 38 patients, aged 18-87 years, received once daily intravenous LVFX doses of 500 mg or 250 mg, depending on their renal function. Four plasma samples were obtained according to a D optimal sampling design. The population pharmacokinetic (PK) parameters of LVFX were estimated using non-linear mixed-effect modeling (NONMEM, ver. 7.2). The CL of LVFX was dependent on creatinine clearance (CLCR) as a covariate. The mean population PK parameters of LVFX in Koreans were as follows: CL (l/hour) = 6.19 ×  (CLCR/75)(1.32). The CL of LVFX in Koreans is expected to be lower than that in Western people.
authors.affiliation: a Department of Internal Medicine , Inje University Haeundae Paik Hospital , Busan , Republic of Korea.
authors.forename: Sungmin
authors.initials: S
authors.lastname: Kiem
authors.affiliation: b Department of Pharmacology, PharmacoGenomics Research Center , Inje University College of Medicine , Busan , Republic of Korea.
authors.forename: Sung-Mun
authors.initials: SM
authors.lastname: Ryu
authors.affiliation: c Department of Clinical Pharmacology , Inje University Busan Paik Hospital , Busan , Republic of Korea.
authors.forename: Yun-Mi
authors.initials: YM
authors.lastname: Lee
authors.affiliation: d University at Buffalo School of Pharmacy and Pharmaceutical Sciences , NY , USA.|e CPL Associates, LLC , USA.
authors.forename: Jerome J
authors.initials: JJ
authors.lastname: Schentag
authors.affiliation: a Department of Internal Medicine , Inje University Haeundae Paik Hospital , Busan , Republic of Korea.
authors.forename: Yang-Wook
authors.initials: YW
authors.lastname: Kim
authors.affiliation: a Department of Internal Medicine , Inje University Haeundae Paik Hospital , Busan , Republic of Korea.
authors.forename: Hyeon-Kuk
authors.initials: HK
authors.lastname: Kim
authors.affiliation: a Department of Internal Medicine , Inje University Haeundae Paik Hospital , Busan , Republic of Korea.
authors.forename: Hang-Jae
authors.initials: HJ
authors.lastname: Jang
authors.affiliation: a Department of Internal Medicine , Inje University Haeundae Paik Hospital , Busan , Republic of Korea.
authors.forename: Yong-Don
authors.initials: YD
authors.lastname: Joo
authors.affiliation: a Department of Internal Medicine , Inje University Haeundae Paik Hospital , Busan , Republic of Korea.
authors.forename: Kyubok
authors.initials: K
authors.lastname: Jin
authors.affiliation: b Department of Pharmacology, PharmacoGenomics Research Center , Inje University College of Medicine , Busan , Republic of Korea.|c Department of Clinical Pharmacology , Inje University Busan Paik Hospital , Busan , Republic of Korea.
authors.forename: Jae-Gook
authors.initials: JG
authors.lastname: Shin
authors.affiliation: c Department of Clinical Pharmacology , Inje University Busan Paik Hospital , Busan , Republic of Korea.
authors.forename: Jong-Lyul
authors.initials: JL
authors.lastname: Ghim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D005260:Female; D006801:Humans; D064704:Levofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D056910:Republic of Korea; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin
keywords: Area under the concentration curve; Clearance; Levofloxacin; Population pharmacokinetics