title: [Therapy for Ocular Graft-vs-Host Disease].
abstract: Therapy for ocular graft-vs-host disease (ocular GvHD) is challenging for ophthalmologists as progress of the disease often occurs rapidly and is unforeseeable. Primary goal is the preservation or restoration of visual acuity, however, studies on ocular GvHD that have investigated therapeutic concepts are limited. In contrast, most therapeutic recommendations from consensus conferences derive from studies on dry eye diseases other than ocular GvHD. This review demonstrates the available therapies in the following categories: local, systemic, surgical and prophylactic. Primary targets are anti-inflammation, anti-fibrosis and lubrification of the ocular surface. In conclusion, studies strictly on ocular GvHD are needed to enable better evidence-based therapeutic decision-making in the future.
authors.affiliation: Kompetenzzentrum Okuläre GvHD, Zentrum für Augenheilkunde, Uniklinik Köln.
authors.forename: P
authors.initials: P
authors.lastname: Steven
authors.affiliation: Kompetenzzentrum Okuläre GvHD, Zentrum für Augenheilkunde, Uniklinik Köln.
authors.forename: L
authors.initials: L
authors.lastname: Sauerbier
authors.affiliation: Kompetenzzentrum Okuläre GvHD, Zentrum für Augenheilkunde, Uniklinik Köln.
authors.forename: S
authors.initials: S
authors.lastname: Siebelmann
authors.affiliation: AG Augenoberfläche, Zentrum für Augenheilkunde, Uniklinik Köln.
authors.forename: U
authors.initials: U
authors.lastname: Gehlsen
authors.affiliation: AG Augenoberfläche, Zentrum für Augenheilkunde, Uniklinik Köln.
authors.forename: V
authors.initials: V
authors.lastname: Tahmaz
authors.affiliation: AG Augenoberfläche, Zentrum für Augenheilkunde, Uniklinik Köln.
authors.forename: S
authors.initials: S
authors.lastname: Wittig
authors.affiliation: Kompetenzzentrum Okuläre GvHD, Zentrum für Augenheilkunde, Uniklinik Köln.
authors.forename: C
authors.initials: C
authors.lastname: Scheid
authors.affiliation: Kompetenzzentrum Okuläre GvHD, Zentrum für Augenheilkunde, Uniklinik Köln.
authors.forename: C
authors.initials: C
authors.lastname: Cursiefen
mesh_terms: D002908:Chronic Disease; D018450:Disease Progression; D005128:Eye Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D011379:Prognosis; D014792:Visual Acuity