title: Thiopurine Resistance in Childhood ALL Is Mediated by PRPS1 Mutations.
abstract: Mutations in the de novo purine biosynthesis enzyme PRPS1 drive thiopurine resistance in relapsed ALL.
mesh_terms: D019008:Drug Resistance, Neoplasm; D006801:Humans; D015122:Mercaptopurine / Q000627:therapeutic use; D009154:Mutation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics*; D011355:Prodrugs / Q000627:therapeutic use; D012268:Ribose-Phosphate Pyrophosphokinase / Q000235:genetics*; D013866:Thioguanine / Q000627:therapeutic use
chemical_list: D011355:Prodrugs; D015122:Mercaptopurine; C510474:PRPS1 protein, human; D012268:Ribose-Phosphate Pyrophosphokinase; D013866:Thioguanine