title: Comparison of ultrasound biomicroscopy and standard ocular ultrasonography for detection of canine uveal cysts.
abstract: OBJECTIVE
  To compare ultrasound biomicroscopy (UBM) with standard ocular ultrasonography for detection of canine uveal cysts and to determine the sensitivity, specificity, and interobserver agreement for detection of uveal cysts with UBM.
  
  
  METHODS
  202 enucleated eyes from 101 dogs.
  
  
  METHODS
  2 examiners examined 202 eyes by means of UBM (50 MHz) to identify uveal cysts. A board-certified radiologist then examined 98 of the 202 eyes by means of standard ocular ultrasonography (7- to 12-MHz linear transducer). Subsequently, 1 examiner dissected all 202 eyes under magnification from an operating microscope to definitively identify uveal cysts. Each examiner was masked to other examiners' findings. Sensitivity, specificity, and interobserver agreement were calculated for detection of cysts by UBM.
  
  
  RESULTS
  Cysts were detected by use of UBM in 55 of 202 (27%) eyes by one examiner and 29 of 202 (14%) eyes by the other. No cysts were detected in the 98 eyes examined with standard ocular ultrasonography. Dissection results revealed that cysts were present in 64 of 202 (32%) eyes, including 29 of 98 (30%) eyes examined by standard ocular ultrasonography. Mean sensitivity of UBM for cyst detection was 47%; mean specificity was 92%. Uveal cysts not identified with UBM were often small (mean diameter, 490 üm). Interobserver agreement was high (κP = 0.81).
  
  
  CONCLUSIONS
  UBM was more effective than standard ocular ultrasonography for detection of uveal cysts in enucleated eyes. Small-diameter cysts were difficult to visualize even with UBM.
authors.forename: LaTisha N
authors.initials: LN
authors.lastname: Taylor
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Townsend
authors.forename: Hock Gan
authors.initials: HG
authors.lastname: Heng
authors.forename: Jean
authors.initials: J
authors.lastname: Stiles
authors.forename: George E
authors.initials: GE
authors.lastname: Moore
mesh_terms: D000818:Animals; D003560:Cysts / Q000000981:diagnostic imaging / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging*; D004285:Dogs; D005260:Female; D008297:Male; D033401:Microscopy, Acoustic / Q000662:veterinary; D011237:Predictive Value of Tests; D014463:Ultrasonography / Q000662:veterinary; D014603:Uveal Diseases / Q000000981:diagnostic imaging / Q000662:veterinary*