title: Nutriepigenomics: the role of nutrition in epigenetic control of human diseases.
abstract: OBJECTIVE
  Nutrients or even diets affect the epigenome by lifelong remodeling. Nutritional imbalances are associated with noncommunicable diseases. Thus, nutriepigenomics is a promising field in the treatment of complex human diseases.
  
  
  RESULTS
  The epigenome is susceptible to changes and can be shaped by nutritional states, especially in prenatal period through transgenerational mechanisms and in early postnatal life when critical developmental processes are taking place. Although more stable, the epigenetic marks in adulthood are also dynamic and modifiable by environmental factors including diet.
  
  
  CONCLUSIONS
  The present review is focused on the most recent knowledge of epigenetically active nutrients/diets including transgenerational inheritance and prenatal predispositions related to increased risk for cancer, metabolic syndrome, and neurodegenerative diseases.
authors.affiliation: aDepartment of Nutritional Sciences, University Vienna, Vienna, Austria bDepartment of Nutrition Science, Purdue University, West Lafaytte, Indiana, USA cDepartment of Gynecology and Obstetrics, Clinical Institute of Medical Genetics, University Medical Centre Ljubljana, Ljubljana, Slovenia.
authors.forename: Marlene
authors.initials: M
authors.lastname: Remely
authors.forename: Barbara
authors.initials: B
authors.lastname: Stefanska
authors.forename: Luca
authors.initials: L
authors.lastname: Lovrecic
authors.forename: Ulrich
authors.initials: U
authors.lastname: Magnet
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Haslberger
mesh_terms: D004032:Diet; D057890:Epigenomics / Q000379:methods*; D005247:Feeding Behavior; D005260:Female; D005786:Gene Expression Regulation; D005819:Genetic Markers; D006801:Humans; D008019:Life Style; D044342:Malnutrition / Q000178:diet therapy / Q000235:genetics; D039382:Maternal Nutritional Physiological Phenomena; D024821:Metabolic Syndrome / Q000178:diet therapy / Q000235:genetics / Q000517:prevention & control; D054647:Nutrigenomics / Q000379:methods*; D009752:Nutritional Status; D011181:Postnatal Care; D011295:Prenatal Care
chemical_list: D005819:Genetic Markers