title: Primary Bone Tumors: Epidemiologic Comparison of 9200 Patients Treated at Beijing Ji Shui Tan Hospital, Beijing, China, With 10 165 Patients at Mayo Clinic, Rochester, Minnesota.
abstract: BACKGROUND
  Although primary bone tumors are extremely rare, the literature suggests that there are variations in the epidemiologic characteristics in different populations. The most frequently cited epidemiologic characteristics of primary bone tumors are derived from a large US series (Mayo Clinic), with no comparable study thus far performed in China.
  
  
  OBJECTIVE
  To identify any potential epidemiologic differences between Chinese patients and a US series of patients.
  
  
  METHODS
  We performed a comparison study between 9200 patients treated at Beijing Ji Shui Tan Hospital (JST) and 10 165 patients treated at Mayo Clinic (MC), Rochester Minnesota. Detailed epidemiologic features were analyzed.
  
  
  RESULTS
  We found that giant cell tumor and osteosarcoma have significantly higher incidences in the JST than the MC patients (P < .001). However, JST patients had a significantly lower incidence of Ewing sarcoma, chordoma, fibrosarcoma, myeloma, and malignant lymphoma (P < .001). For most benign and malignant bone tumors, the Chinese cohort had a more distinct male predominance than the US cohort. Malignant bone tumors had a monomodal age distribution in the JST patient group, with a bimodal age distribution in the MC cohort. Also, there were was a predilection for tumors of the femur and tibia among the JST patients (P < .001).
  
  
  CONCLUSIONS
  Our data confirm that epidemiologic variations of primary bone tumors exist in different populations. Factors that may contribute to these observed differences are proposed and discussed.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Niu
authors.forename: Hairong
authors.initials: H
authors.lastname: Xu
authors.forename: Carrie Y
authors.initials: CY
authors.lastname: Inwards
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
authors.forename: G Douglas
authors.initials: GD
authors.lastname: Letson
authors.affiliation: From the Departments of Orthopedic Oncology Surgery (Drs Niu, Xu, and Li) and Pathology (Dr Ding), Beijing Ji Shui Tan Hospital, Peking University, Beijing, China; the Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (Dr Inwards); the Department of Sarcoma (Drs Leston and Bui) and Anatomic Pathology Service (Dr Bui), H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
authors.forename: Marilyn M
authors.initials: MM
authors.lastname: Bui
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000453:epidemiology* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012512:Sarcoma, Ewing / Q000453:epidemiology; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology; D055815:Young Adult