title: A new cyclolignan glycoside from the tubers of Pinellia ternata.
abstract: A new 2,7'-type cyclolignan glycoside, cyclolignanyingoside A (1), together with six known compounds (2-7) were isolated from the tubers of Pinellia ternata (Thunb.) Breit. The structure of 1 was elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses, HR-ESI-MS, and CD spectrometry. The cytotoxic, antioxidant and tyrosinase-inhibiting activities of all the isolates were determined. However, all the isolates exhibited no activity on the selected cell lines (Hep-3B, Bcap-37, and MCF-7). In addition, compounds 1-3 and 7 exhibited strong 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) free radical scavenging activity, and compounds 2 and 4 showed a moderate mushroom tyrsinase inhibitory activity.
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Ying-Ying
authors.initials: YY
authors.lastname: Wu
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Huang
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhou
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Dan-Qi
authors.initials: DQ
authors.lastname: Li
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Qing-Bo
authors.initials: QB
authors.lastname: Liu
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Ling-Zhi
authors.initials: LZ
authors.lastname: Li
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Xin-Jia
authors.initials: XJ
authors.lastname: Yan
authors.affiliation: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.|b Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education) , Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors.forename: Shao-Jiang
authors.initials: SJ
authors.lastname: Song
mesh_terms: D000363:Agaricales / Q000187:drug effects / Q000201:enzymology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D030021:Pinellia / Q000737:chemistry*; D035281:Plant Tubers / Q000737:chemistry
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D017705:Lignans; C000605694:cyclolignanyingoside A; D014442:Monophenol Monooxygenase
keywords: Araceae; Pinellia ternata; antioxidant activity; cyclolignan glycoside; cytotoxic activity; tyrosinase-inhibiting activity