title: Pd-Catalyzed Diamination of 1,2,4-Triazinyl Complexant Scaffolds.
abstract: As part of ongoing efforts in this laboratory to design and synthesize multidentate soft-N-donors as effective complexants for chemoselective minor actinide extraction from used nuclear fuel, a series of aminated mono-1,2,4-triazinylpyridines were required. This study focuses on streamlining convergent access to a diverse array of functionalized N-donors using Pd-catalysis from a common synthon affording access to pyridinyl triazines as the 4,4'-amino derivatives which are commercially limited and unsuccessful in traditional condensation chemistry. A general Pd-catalyzed method for the double amination of functionalized pyridinyl-1,2,4-triazines with low catalyst/ligand loadings enabling the formation of 16 novel complexants is presented.
authors.affiliation: Department of Chemistry, Tennessee Technological University, 55 University Drive, Cookeville, Tennessee 38501, United States.
authors.forename: Serene
authors.initials: S
authors.lastname: Tai
authors.affiliation: Department of Chemistry, Tennessee Technological University, 55 University Drive, Cookeville, Tennessee 38501, United States.
authors.forename: Evan J
authors.initials: EJ
authors.lastname: Dover
authors.affiliation: Department of Chemistry, Tennessee Technological University, 55 University Drive, Cookeville, Tennessee 38501, United States.
authors.forename: Sydney V
authors.initials: SV
authors.lastname: Marchi
authors.affiliation: Department of Chemistry, Tennessee Technological University, 55 University Drive, Cookeville, Tennessee 38501, United States.
authors.forename: Jesse D
authors.initials: JD
authors.lastname: Carrick
mesh_terms: D000586:Amination; D002384:Catalysis; D008024:Ligands; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D008024:Ligands; D011725:Pyridines; D014227:Triazines; D010165:Palladium