title: Iodine promoted α-hydroxylation of ketones.
abstract: A novel method for α-hydroxylation of ketones using substoichiometric amount of iodine under metal-free conditions is described. This method has been successfully employed in synthesizing a variety of heterocyclic compounds, which are useful precursors. α-Hydroxylation of diketones and triketones are illustrated. This strategy provides a novel, efficient, mild and inexpensive method for α-hydroxylation of aryl ketones using a sub-stoichiometric amount of molecular iodine.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, Karnataka, India. prabhu@orgchem.iisc.ernet.in.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Siddaraju
authors.forename: Kandikere Ramaiah
authors.initials: KR
authors.lastname: Prabhu
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry*; D006900:Hydroxylation; D007455:Iodine / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D006841:Hydrocarbons, Aromatic; D007659:Ketones; D007455:Iodine