title: Multimodality imaging of retinal astrocytoma.
abstract: OBJECTIVE
  Cross-characterization of retinal astrocytomas (RA) using ocular diagnostic imaging techniques.
  
  
  METHODS
  Fundus photography, fluorescein angiography, optical coherence tomography, fundus autofluorescence images, and ultrasonography were used to define characteristics of RA.
  
  
  RESULTS
  Thirteen patients had sporadic RA and 12 had tuberous sclerosis. Of the latter, 1 patient had multiple (n = 14), bilateral tumors and was excluded so as not to skew the analysis. Of those patients with a solitary RA, 63% were juxtapapillary. All were white to yellow. A mulberry-shaped surface was observed in 33%. Fluorescein angiography revealed intrinsic tumor vessels and late diffuse tumor staining in 42%. Optical coherence tomography revealed cells spreading from the tumor surface into the vitreous (75%), intraretinal fluid (25%), and multiple, ovoid hypolucencies within the tumor stroma (54%). Fundus autofluorescent imaging revealed that hypolucencies were hyperautofluorescent and solid tumor stroma appeared hypoautofluorescent. B-scan imaging revealed moderate to high internal tumor reflectivity (100%) with orbital shadowing (46%). Optical coherence tomography revealed a mean tumor thickness of 0.8 mm. Ultrasound imaging showed a mean thickness of 1.4 mm (range 1.0-1.7). Of the 21 patients subsequently followed in our centers, no tumor growth was noted (mean 54 months, range 1-96).
  
  
  CONCLUSIONS
  This study reveals unique characteristics of RA and suggests that RA were most commonly amelanotic, moderate to high echoic, ≤1.7 mm in thickness, near the optic disc, and nonprogressive. When observed, a mulberry-shaped surface was pathognomonic.
authors.affiliation: The New York Eye Cancer Center, New York, NY - USA.|The New York Eye and Ear Infirmary of Mt. Sinai, New York, NY - USA.
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Semenova
authors.affiliation: Ophthalmology Unit, University of Bologna, S. Orsola Malpighi Hospital, Bologna - Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Veronese
authors.affiliation: Ophthalmology Unit, University of Bologna, S. Orsola Malpighi Hospital, Bologna - Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciardella
authors.affiliation: S. Orsola Malpighi Hospital, Bologna - Italy.
authors.forename: Eleonora Benedetta
authors.initials: EB
authors.lastname: Marcheggiani
authors.affiliation: The New York Eye Cancer Center, New York, NY - USA.
authors.forename: Sabah
authors.initials: S
authors.lastname: Shah
authors.affiliation: The New York Eye Cancer Center, New York, NY - USA.
authors.forename: Lucia
authors.initials: L
authors.lastname: De-Pablo-Gomez-de-Liaño
authors.affiliation: The New York Eye Cancer Center, New York, NY - USA.|The New York Eye and Ear Infirmary of Mt. Sinai, New York, NY - USA.
authors.forename: Paul T
authors.initials: PT
authors.lastname: Finger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009898:Optic Disk / Q000473:pathology; D010781:Photography; D019572:Retinal Neoplasms / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*