title: Systemic Inflammatory Marker CRP Was Better Predictor of Readmission for AECOPD Than Sputum Inflammatory Markers.
abstract: BACKGROUND
  Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) readmission contributes considerably to the worse outcomes for COPD patients. Predictors for readmission include some socio-demographic variables and the severity of the underlying disease, however, few evidence suggested whether persistently heightened airway or systemic inflammation was related to recurrence of AECOPD. The aim of this study was to evaluate role of airway and systemic inflammatory biomarkers during AECOPD on predicting readmission for AECOPD.
  
  
  METHODS
  Consecutive hospitalized patients with AECOPD were recruited. Inflammatory and clinical indices were evaluated at the day of admission before starting therapy and the day of planned discharge (day 10-14). Predictors for readmission were assessed by binary logistic regression model.
  
  
  RESULTS
  93 patients were included with 51 patients (54.8%) were readmitted due to AECOPD at least once during 1 year following the index admission. The logistic regression model indicated that age (OR=1.072, 95%CI: 1.012-1.135, P=.017), hs-CRP (high sensitive-C reactive protein) at day 14 (OR=1.392, 95%CI: 1.131-1.712, P=.002), CAT value at day 14 (OR=1.12, 95%CI: 1.031-1.217, P=.007) were the independent variables statistically significant in predicting rehospitalization.
  
  
  CONCLUSIONS
  Systemic inflammatory marker CRP was a better predictor of readmission than sputum inflammatory markers. CAT score and age were also useful to predict readmission.
authors.affiliation: Departament of Respiratory Diseases, Peking University Third Hospital, Pequín, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jing
authors.affiliation: Departament of Respiratory Diseases, Peking University Third Hospital, Pequín, China. Electronic address: doudou_1977@163.com.
authors.forename: Chang
authors.initials: C
authors.lastname: Chun
authors.affiliation: Departament of Respiratory Diseases, Peking University Third Hospital, Pequín, China.
authors.forename: Shen
authors.initials: S
authors.lastname: Ning
authors.affiliation: Departament of Respiratory Diseases, Peking University Third Hospital, Pequín, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Hong
authors.affiliation: Departament of Respiratory Diseases, Peking University Third Hospital, Pequín, China.
authors.forename: He
authors.initials: H
authors.lastname: Bei
authors.affiliation: Departament of Respiratory Diseases, Peking University Third Hospital, Pequín, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Wan-Zhen
mesh_terms: D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010359:Patient Readmission / Q000706:statistics & numerical data*; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism* / Q000628:therapy; D012044:Regression Analysis; D013183:Sputum / Q000737:chemistry*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein
keywords: Estado de salud; Exacerbaciones agudas de enfermedad pulmonar obstructiva crónica; Exacerbation of chronic obstructive pulmonary disease; Factor inflamatorio; Health status; Inflammatory factor; Rehospitalización; Rehospitalization