title: Type 2 diabetes diminishes the benefits of dietary antioxidants: Evidence from the different free radical scavenging potential.
abstract: The development of food fortified with polyphenols and polyphenol-rich foods represents a novel approach for preventing or managing type 2 diabetes. Herein, taking advantage of several radical scavenging, the impact of plasma proteins in diabetes on the benefits of dietary polyphenols was investigated. It illustrated that plasma proteins masked the dietary polyphenols, thus reducing their radical scavenging potential. The plasma proteins from type 2 diabetics bind and protect (i.e., mask) the polyphenol antioxidants less effectively than the non-glycosylated ones in healthy blood do. In the blood of diabetics the less-protected (non-masked) antioxidants react with free radicals before being delivered to the tissues that need them. We should pay more attention to in vivo benefits of dietary polyphenols for type 2 diabetics.
authors.affiliation: Department of Chemistry, Central South University, Changsha 410083, PR China; Institut für Pharmazie und Lebensmittelchemie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany.
authors.forename: Hui
authors.initials: H
authors.lastname: Cao
authors.affiliation: Department of Chemistry, Central South University, Changsha 410083, PR China.
authors.forename: Yixi
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Chemistry, Central South University, Changsha 410083, PR China. Electronic address: xqchencsu@yahoo.com.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Chen
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D005609:Free Radicals / Q000097:blood* / Q000737:chemistry; D006801:Humans; D059808:Polyphenols / Q000737:chemistry / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D059808:Polyphenols
keywords: Antioxidants; Diabetes; Free radical scavenging; Plasma proteins; Polyphenols