title: Chemical composition, N-nitrosamine inhibition and antioxidant and antimicrobial properties of essential oil from Coreopsis tinctoria flowering tops.
abstract: Coreopsis tinctoria flowering (CTF) tops from the Kunlun Mountains in Xinjing (north-western China) have been used for tea production for about a century. This study was to assess antioxidant, nitrite-scavenging and N-nitrosamine inhibitory and antimicrobial activities of the essential oil extracted from CTF tops. The essential oil was extracted through hydrodistillation and its chemical compositions were analysed by GC-MS. Seventy compounds of the oil were identified, representing 81.87% of total oil. The antioxidant capacities of the oil with IC50 values for scavenging DPPH and ABTS were 287.66 ± 12.60 and 1.251 ± 0.127 μg mL(- 1), respectively. The nitrite-scavenging and N-nitrosamine inhibitory activities (IC50) were 0.3912 ± 0.0127 and 0.6564 ± 0.036 μg mL(- 1), respectively. The oil has a certain antimicrobial capacity, but its capacity was weaker than that of penicillinG (24 μg mL(- 1)). The oil showed antioxidant and antimicrobial capacities and had a stronger nitrite-scavenging and N-nitrosamine inhibitory properties.
authors.affiliation: a College of Pharmacy, Shihezi University , Shihezi 832000 , Xinjiang , P.R. China.|b Ministry of Education Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Shihezi University , Shihezi 832000 , Xinjiang , P.R. China.
authors.forename: Xincheng
authors.initials: X
authors.lastname: Yao
authors.affiliation: a College of Pharmacy, Shihezi University , Shihezi 832000 , Xinjiang , P.R. China.|b Ministry of Education Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Shihezi University , Shihezi 832000 , Xinjiang , P.R. China.
authors.forename: Xinbing
authors.initials: X
authors.lastname: Wang
authors.affiliation: c School of Chemistry and Chemical Engineering, Shihezi University , Shihezi 832002 , Xinjiang , P.R. China.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Gu
authors.affiliation: d Key Laboratory of Protection and Utilization of Biological Resources, College of Life Science, Tarim University , Alar 843300 , Xinjiang , P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zeng
authors.affiliation: a College of Pharmacy, Shihezi University , Shihezi 832000 , Xinjiang , P.R. China.|b Ministry of Education Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Shihezi University , Shihezi 832000 , Xinjiang , P.R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.affiliation: a College of Pharmacy, Shihezi University , Shihezi 832000 , Xinjiang , P.R. China.|b Ministry of Education Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Shihezi University , Shihezi 832000 , Xinjiang , P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Tang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D002681:China; D031945:Coreopsis / Q000737:chemistry*; D035263:Flowering Tops / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009602:Nitrosamines / Q000037:antagonists & inhibitors*; D009822:Oils, Volatile / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D009602:Nitrosamines; D009822:Oils, Volatile; D010936:Plant Extracts; D010938:Plant Oils
keywords: Coreopsis tinctoria Nutt; N-nitrosamine inhibition; antimicrobial activity; antioxidant activity; chemical compositions; essential oil