title: The human cytomegalovirus non-coding Beta2.7 RNA as a novel therapeutic for Parkinson's disease--Translational research with no translation.
abstract: Human cytomegalovirus (HCMV) encodes abundant numbers of microRNAs (miRNAs) and other non-coding RNAs (ncRNAs) whose functions are presently under intense investigation. In this chapter, we discuss the function of one of the more well characterised virus-encoded ncRNAs, derived from the viral major early gene (Beta2.7). This RNA plays an anti-apoptotic role during infection by directly interacting with mitochondrial complex I to help maintain high levels of ATP production and by preventing the stress induced re-localisation of retinoid/interferon-induced mortality-19 protein, GRIM-19. We then go on to describe how an 800 nucleotide sub-domain of the Beta2.7 transcript, p137, has been exploited in the development of a novel therapeutic for the treatment of Parkinson's disease.
authors.affiliation: Department of Medicine, Addenbrooke's Hospital, Hills Road, England CB2 0QQ UK. Electronic address: elp27@cam.ac.uk.
authors.forename: Emma
authors.initials: E
authors.lastname: Poole
authors.affiliation: Department of Neurology, Addenbrooke's Hospital, Hills Road, England CB2 0QQ, UK.
authors.forename: Wei Li
authors.initials: WL
authors.lastname: Kuan
authors.affiliation: Department of Neurology, Addenbrooke's Hospital, Hills Road, England CB2 0QQ, UK.
authors.forename: Roger
authors.initials: R
authors.lastname: Barker
authors.affiliation: Department of Medicine, Addenbrooke's Hospital, Hills Road, England CB2 0QQ UK. Electronic address: js152@cam.ac.uk.
authors.forename: John
authors.initials: J
authors.lastname: Sinclair
mesh_terms: D000818:Animals; D003587:Cytomegalovirus / Q000235:genetics / Q000378:metabolism*; D003586:Cytomegalovirus Infections / Q000821:virology*; D006801:Humans; D010300:Parkinson Disease / Q000188:drug therapy*; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D012367:RNA, Viral / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D057170:Translational Research, Biomedical
chemical_list: D022661:RNA, Untranslated; D012367:RNA, Viral
keywords: Human cytomegalovirus; Parkinson's disease; Viral miRNAs; Viral non-coding RNAs