title: [Tamsulosin efficacy and safety for conservative management of renal colic: systematic review and meta-analysis of randomized controlled trials].
abstract: OBJECTIVE
  The aim is to evaluate tamsulosin efficacy and safety on the expulsion of distal ureteral stones compared to a standard therapy.
  
  
  METHODS
  Systematic searches were conducted on PubMed, SCOPUS and The Cochrane Library so as to identify randomized and controlled clinical trials in patients treated with tamsulosin with ureteral stone expulsion and adverse events published until 2014 December, without language restriction. Treatment effect was calculated along with the 95% confidence interval (95% CI), using the variance inverse method for random effects. Heterogeneity was determined by I(2). Publication bias was assessed by Egger test.
  
  
  RESULTS
  The search identified 480 articles. Thirty-eight met the selection criteria, a total of 3,107 patients. The relative risk (RR) of expulsion was 1.53 (95% CI 1.38-1.69; I(2)=71%.), while the RR of adverse effects was 1.79 (95% CI 1.19-2,71; I(2)=0).
  
  
  CONCLUSIONS
  Tamsulosin treatment seems to bring on the expulsion of distal ureteral stones, although at the expense of an appreciable risk of side effects.
authors.affiliation: Centre d'Atenció Primària Gòtic, Barcelona, España. Electronic address: alexpben2010@gmail.com.
authors.forename: Mència
authors.initials: M
authors.lastname: Benítez Camps
authors.affiliation: Centre d'Atenció Primària Can Vidalet, Esplugues de Llobregat, Barcelona, España.
authors.forename: M Jesus
authors.initials: MJ
authors.lastname: Cerain Herrero
authors.affiliation: Centre d'Atenció Primària La Pau, Sant Martí, Barcelona, España.
authors.forename: Noemi
authors.initials: N
authors.lastname: de Miguel Llorente
authors.affiliation: Centre d'Atenció Primària La Pau, Sant Martí, Barcelona, España.
authors.forename: Elisabet
authors.initials: E
authors.lastname: Martorell Sole
authors.affiliation: Unitat de Suport de la Recerca Tarragona, Institut Universitari d'Investigació en Atenció Primària (IDIAP) Jordi Gol, Tarragona, España.
authors.forename: Gemma
authors.initials: G
authors.lastname: Flores Mateo
authors.affiliation: Centre d'Atenció Primària Sagrada Familia, Barcelona, España.
authors.forename: Anna M
authors.initials: AM
authors.lastname: Pedro Pijoan
authors.affiliation: Unidad Docente LLeida, Lleida, España.
authors.forename: Carlos
authors.initials: C
authors.lastname: Murillo-Huapaya
mesh_terms: D006801:Humans; D016032:Randomized Controlled Trials as Topic; D056844:Renal Colic / Q000188:drug therapy* / Q000209:etiology; D013449:Sulfonamides / Q000627:therapeutic use*; D000077409:Tamsulosin; D016896:Treatment Outcome; D014514:Ureteral Calculi / Q000150:complications / Q000188:drug therapy*; D064804:Urological Agents / Q000627:therapeutic use*
chemical_list: D013449:Sulfonamides; D064804:Urological Agents; D000077409:Tamsulosin
keywords: Efectos adversos; Expulsion rate; Litiasis renal; Side effects; Tamsulosin; Tamsulosina; Tasa de expulsión; Urolithiasis