title: Assessment methods and prevalence of cognitive dysfunction in patients with low-grade glioma: A systematic review.
abstract: OBJECTIVE
  To systematically review the literature for studies on cognitive functioning in patients with low-grade glioma to evaluate assessment methods and prevalence of cognitive dysfunction.
  
  
  METHODS
  A search was made in PubMed, Embase, and PsycINFO for articles published between January 2002 and June 2012 using cognition, memory, attention, executive functioning, and low-grade glioma as search terms.
  
  
  METHODS
  Two reviewers independently performed the study selection and data extraction. Inclusion criteria were: studies including at least 10 adult patients, with suspected or confirmed low-grade glioma and cognitive functioning as outcome measure.
  
  
  METHODS
  A standard data extraction form was used, with items regarding study quality, patient characteristics, type of measurement instruments, cognitive domain, definition of cognitive dysfunction, and reported prevalence.
  
  
  RESULTS
  Of the 312 articles screened on title/abstract, 69 were screened on full-text and, finally, 17 were included. A total of 46 different measurement instruments were found for the assessment of cognitive functioning; 5 of these were used 5 or more times. There was variability in the definition of cognitive dysfunction. The reported prevalence of cognitive dysfunction ranged from 19% to 83%.
  
  
  CONCLUSIONS
  Many patients with low-grade glioma experience cognitive dysfunction. However, there is no consensus on how to assess cognitive functioning in these patients.
authors.affiliation: Rijndam Rehabilitation Center, Rotterdam Neurorehabilitation Research (RoNeRes), PO Box 23181, NL-3001 KD Rotterdam, The Netherlands . EvCoevorden@rijndam.nl.
authors.forename: Ellen M P
authors.initials: EM
authors.lastname: van Loon
authors.forename: Majanka H
authors.initials: MH
authors.lastname: Heijenbrok-Kal
authors.forename: Wouter S
authors.initials: WS
authors.lastname: van Loon
authors.forename: Martin J
authors.initials: MJ
authors.lastname: van den Bent
authors.forename: Arnaud J P E
authors.initials: AJ
authors.lastname: Vincent
authors.forename: Inge
authors.initials: I
authors.lastname: de Koning
authors.forename: Gerard M
authors.initials: GM
authors.lastname: Ribbers
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005910:Glioma / Q000150:complications* / Q000473:pathology; D006801:Humans; D009483:Neuropsychological Tests; D015995:Prevalence