title: Anaplastic lymphoma kinase gene expression in small round cell tumors of childhood--a comparative ımmunohistochemical study.
abstract: The focus of this study was to investigate anaplastic lymphoma kinase (ALK) expression by immunohistochemistry using a highly specific antibody. Distribution and frequency of ALK expression may provide a clue for ALK inhibitor use in small round cell tumors of childhood. The study group involved 76 small round cell tumors of childhood, which composed of 11 rhabdomyosarcomas, 13 Wilms tumors, 7 Ewing sarcoma/primitive neuroectodermal tumors, 34 peripheral neuroblastic tumors, and 11 acute lymphoblastic lymphoma. Anaplastic lymphoma kinase protein expression in small round cell tumors of childhood is poorly described in the literature. The findings of our study highlight a potential and possible role of targeting ALK in pediatric solid tumors by using ALK immunohistochemistry. Anaplastic lymphoma kinase may also have an oncogenic role in rhabdomyosarcomas and peripheral neuroblastic tumors, and they may possibly be treated with ALK inhibitors. Anaplastic lymphoma kinase expression in Wilms tumors is not reported in the literature, previously. Our study evaluated ALK expression in Wilms tumor samples.
authors.affiliation: Pathology Department, Ankara Children's Hematology and Oncology Research and Training Hospital, Ankara, Turkey. Electronic address: esrakaraku@gmail.com.
authors.forename: Esra
authors.initials: E
authors.lastname: Karakuş
authors.affiliation: Pediatric Oncology Department, Ankara Children's Hematology and Oncology Research and Training Hospital, Ankara, Turkey.
authors.forename: Suna
authors.initials: S
authors.lastname: Emir
authors.affiliation: Department of Pathology, Ordu University Faculty of Medicine, Ordu, Turkey.
authors.forename: Ayper
authors.initials: A
authors.lastname: Kaçar
authors.affiliation: Department of Immunology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Resul
authors.initials: R
authors.lastname: Karakuş
authors.affiliation: Departments of Pediatrics and Pediatric Oncology, Private Memorial Ankara Hospital, Ankara, Turkey.
authors.forename: Hacı Ahmet
authors.initials: HA
authors.lastname: Demir
authors.affiliation: Pediatric Oncology Department, Ankara Children's Hematology and Oncology Research and Training Hospital, Ankara, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Özyörük
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000235:genetics; D018288:Carcinoma, Small Cell / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D058405:Desmoplastic Small Round Cell Tumor / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009447:Neuroblastoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D018242:Neuroectodermal Tumors, Primitive / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D012208:Rhabdomyosarcoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D012512:Sarcoma, Ewing / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D009396:Wilms Tumor / Q000201:enzymology / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases
keywords: Anaplastic lymphoma kinase; Ewing sarcoma; Immunohistochemistry; Neuroblastoma; Rhabdomyosarcoma; Wilms tumor