title: [Roles of the cross talk between MAP kinases and Keap1-Nrf2-ARE signaling pathways in chronic obstructive pulmonary disease].
abstract: Chronic obstructive pulmonary disease (COPD), a common preventable and treatable disease, is characterized by airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways. Its main pathological manifestations include airway inflammation, mucus hypersecretion, oxidative stress and apoptotic epithelial cells. Recent research suggests that MAP kinases and Keap1-Nrf2-ARE signaling pathway are involved in the pathological process of inflammation and oxidative stress. This review explores the potential role of the cross talk of these signaling pathways in airway inflammation, mucus hypersecretion, oxidative stress and apoptotic epithelial cells. To clarify the roles of cross talk between MAP kinases and Keap1-Nrf2-ARE signaling pathway, we also focus on the drugs related to that in the treatment of COPD, and it provides ideas for more drug research in the treatment of COPD.
authors.forename: Shu-Jun
authors.initials: SJ
authors.lastname: Wang
authors.forename: Ya-Jun
authors.initials: YJ
authors.lastname: Chen
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Wang
authors.forename: Dian-Lei
authors.initials: DL
authors.lastname: Wang
authors.forename: Chen-Yin
authors.initials: CY
authors.lastname: Wang
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Yang
authors.forename: Jin-Pei
authors.initials: JP
authors.lastname: Chen
mesh_terms: D017209:Apoptosis; D004847:Epithelial Cells / Q000166:cytology; D006801:Humans; D007249:Inflammation; D047908:Intracellular Signaling Peptides and Proteins; D000072019:Kelch-Like ECH-Associated Protein 1; D020928:Mitogen-Activated Protein Kinases; D051267:NF-E2-Related Factor 2; D018384:Oxidative Stress; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism*; D012137:Respiratory System; D015398:Signal Transduction
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C431364:KEAP1 protein, human; D000072019:Kelch-Like ECH-Associated Protein 1; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D020928:Mitogen-Activated Protein Kinases