title: Alike but Different: RAF Paralogs and Their Signaling Outputs.
abstract: RAF links RAS, one of the most potent human oncogenes, to its effector ERK and to proliferation. This role is evolutionarily conserved, but while simpler multicellular organisms express one RAF, mammals have three. This Minireview highlights common and divergent features of RAF paralogs, their signaling outputs, and roles in tumorigenesis.
authors.affiliation: Department of Microbiology, Immunology and Genetics; Center of Molecular Biology, University of Vienna; Max F. Perutz Laboratories, Doktor-Bohr-Gasse 9, 1030 Vienna, Austria.
authors.forename: Enrico
authors.initials: E
authors.lastname: Desideri
authors.affiliation: Department of Microbiology, Immunology and Genetics; Center of Molecular Biology, University of Vienna; Max F. Perutz Laboratories, Doktor-Bohr-Gasse 9, 1030 Vienna, Austria.
authors.forename: Anna Lina
authors.initials: AL
authors.lastname: Cavallo
authors.affiliation: Department of Microbiology, Immunology and Genetics; Center of Molecular Biology, University of Vienna; Max F. Perutz Laboratories, Doktor-Bohr-Gasse 9, 1030 Vienna, Austria. Electronic address: manuela.baccarini@univie.ac.at.
authors.forename: Manuela
authors.initials: M
authors.lastname: Baccarini
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006801:Humans; D020935:MAP Kinase Signaling System; D009369:Neoplasms / Q000378:metabolism; D019908:Proto-Oncogene Proteins c-raf / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D019908:Proto-Oncogene Proteins c-raf; D048049:Extracellular Signal-Regulated MAP Kinases