title: Unlocking the promise of oncolytic virotherapy in glioma: combination with chemotherapy to enhance efficacy.
abstract: Malignant glioma is a relentless burden to both patients and clinicians, and calls for innovation to overcome the limitations in current management. Glioma therapy using viruses has been investigated to accentuate the nature of a virus, killing a host tumor cell during its replication. As virus mediated approaches progress with promising therapeutic advantages, combination therapy with chemotherapy and oncolytic viruses has emerged as a more synergistic and possibly efficacious therapy. Here, we will review malignant glioma as well as prior experience with oncolytic viruses, chemotherapy and combination of the two, examining how the combination can be optimized in the future.
authors.affiliation: Department of Neurosurgery, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
authors.forename: Drew A
authors.initials: DA
authors.lastname: Spencer
authors.forename: Jacob S
authors.initials: JS
authors.lastname: Young
authors.forename: Deepak
authors.initials: D
authors.lastname: Kanojia
authors.forename: Julius W
authors.initials: JW
authors.lastname: Kim
authors.forename: Sean P
authors.initials: SP
authors.lastname: Polster
authors.forename: Jason P
authors.initials: JP
authors.lastname: Murphy
authors.forename: Maciej S
authors.initials: MS
authors.lastname: Lesniak
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000379:methods*; D005910:Glioma / Q000188:drug therapy / Q000628:therapy* / Q000821:virology*; D006801:Humans; D050130:Oncolytic Virotherapy / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents