title: Margination regimes and drainage transition in confined multicomponent suspensions.
abstract: A mechanistic theory is developed to describe segregation in confined multicomponent suspensions such as blood. It incorporates the two key phenomena arising in these systems at low Reynolds number: hydrodynamic pair collisions and wall-induced migration. In simple shear flow, several regimes of segregation arise, depending on the value of a "margination parameter" M. Most importantly, there is a critical value of M below which a sharp "drainage transition" occurs: one component is completely depleted from the bulk flow to the vicinity of the walls. Direct simulations also exhibit this transition as the size or flexibility ratio of the components changes.
authors.affiliation: Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706-1691, USA.
authors.forename: Rafael G
authors.initials: RG
authors.lastname: Henríquez Rivera
authors.affiliation: Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706-1691, USA.
authors.forename: Kushal
authors.initials: K
authors.lastname: Sinha
authors.affiliation: Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706-1691, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Graham
mesh_terms: D001769:Blood; D001774:Blood Chemical Analysis; D057446:Hydrodynamics; D008954:Models, Biological; D008956:Models, Chemical; D013535:Suspensions / Q000737:chemistry*
chemical_list: D013535:Suspensions