title: Temperature dependent conformational change of dengue virus.
abstract: Dengue virus is the causative agent of dengue virus fever. It infects about 400 million people per year and leads to about 21,000 deaths annually. There is available neither a fully successful vaccine nor a successful drug therapy. Some dengue virus serotypes undergo a temperature dependent conformational change from a 'smooth' form at lower temperatures to a 'bumpy' form at temperatures approaching 37°C, the human body temperature. The bumpy structure is less stable and is probably an intermediate in the formation of a fusogenic virus particle.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA; National Key Laboratory of Biomacromolecules, University of Chinese Academy of Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Xinzheng
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Sun
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. Electronic address: mr@purdue.edu.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rossmann
mesh_terms: D001831:Body Temperature; D003716:Dengue Virus / Q000472:pathogenicity / Q000502:physiology* / Q000648:ultrastructure*; D006801:Humans; D013696:Temperature; D014771:Virion / Q000648:ultrastructure