title: Experimental pig-to-pig transmission dynamics for African swine fever virus, Georgia 2007/1 strain.
abstract: African swine fever virus (ASFV) continues to cause outbreaks in domestic pigs and wild boar in Eastern European countries. To gain insights into its transmission dynamics, we estimated the pig-to-pig basic reproduction number (R 0) for the Georgia 2007/1 ASFV strain using a stochastic susceptible-exposed-infectious-recovered (SEIR) model with parameters estimated from transmission experiments. Models showed that R 0 is 2·8 [95% confidence interval (CI) 1·3-4·8] within a pen and 1·4 (95% CI 0·6-2·4) between pens. The results furthermore suggest that ASFV genome detection in oronasal samples is an effective diagnostic tool for early detection of infection. This study provides quantitative information on transmission parameters for ASFV in domestic pigs, which are required to more effectively assess the potential impact of strategies for the control of between-farm epidemic spread in European countries.
authors.affiliation: Royal Veterinary College,Department of Production and Population Health,Hatfield,UK.
authors.forename: C
authors.initials: C
authors.lastname: Guinat
authors.affiliation: The Pirbright Institute,Pirbright,UK.
authors.forename: S
authors.initials: S
authors.lastname: Gubbins
authors.affiliation: Royal Veterinary College,Department of Production and Population Health,Hatfield,UK.
authors.forename: T
authors.initials: T
authors.lastname: Vergne
authors.affiliation: The Pirbright Institute,Pirbright,UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Gonzales
authors.affiliation: The Pirbright Institute,Pirbright,UK.
authors.forename: L
authors.initials: L
authors.lastname: Dixon
authors.affiliation: Royal Veterinary College,Department of Production and Population Health,Hatfield,UK.
authors.forename: D U
authors.initials: DU
authors.lastname: Pfeiffer
mesh_terms: D000357:African Swine Fever / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D000358:African Swine Fever Virus / Q000502:physiology*; D000818:Animals; D050936:Basic Reproduction Number / Q000662:veterinary*; D005061:Europe, Eastern / Q000453:epidemiology; D008962:Models, Theoretical; D013269:Stochastic Processes; D013552:Swine
keywords: African swine fever; basic reproduction number; domestic pigs; modelling; transmission