title: Minimal-change disease as a paraneoplastic syndrome in a patient with ovarian carcinoma.
abstract: Minimal-change disease (MCD) is an exceptional paraneoplastic presentation. We are describing the case of an ovarian paraneoplastic nephrotic syndrome. The kidney biopsy was consistent with MCD. Steroids and immunosuppressive therapy were given with no change in the nephrotic-range proteinuria. A complete resolution of the nephrotic syndrome was soon observed with improvement of her clinical condition after five cycles of chemotherapy with paclitaxel and carboplatin and tumor-debulking surgery. Ovarian carcinoma paraneoplastic nephrotic syndrome secondary to MCD is an extremely rare event, which is important to recognize since it is responsive to the standard chemotherapy.
authors.affiliation: Department of Internal Medicine, CES University-Fundacion Valle del Lili, Cali, Colombia.
authors.forename: Guido R
authors.initials: GR
authors.lastname: González-Fontal
authors.affiliation: Division of Hematology/oncology, Department of Medicine, CES University-Fundacion Valle del Lili, Cali, Colombia.
authors.forename: Juan G
authors.initials: JG
authors.lastname: Restrepo
authors.affiliation: Division of Infectious Diseases, University of Colorado Denver, Aurora, CO, USA.
authors.forename: Andrés F
authors.initials: AF
authors.lastname: Henao-Martínez
keywords: minimal-change disease; nephrotic syndrome; ovarian carcinoma; paraneoplastic syndrome