title: Goal attainments and their discrepancies for low density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) in over 2,000 Chinese patients with known coronary artery disease or type 2 diabetes.
abstract: OBJECTIVE
  Low density lipoprotein cholesterol (LDL-C) is primary treatment target for patients with dislipidemia. The apolipoprotein B (apo B), an emerging biomarker for cardiovascular risk prediction, appears to be superior to the LDL-C. However, little is known about goal attainments and their discrepancies for LDL-C and apo B in Chinese patients with known CAD or DM.
  
  
  METHODS
  A total of 2,172 hospitalized patients with known coronary artery disease (CAD) or DM, aged >27 years of old, were enrolled. The success rates for apo B and LDL-C goal attainments were evaluated and compared by categorization and by sex.
  
  
  RESULTS
  When the success rates for apo B were compared with the ones for LDL-C, the former was higher than the latter across all categorizations, with the statistically significant differences seen in all patients, CAD alone and DM alone (P<0.0001), but not in coexistence of CAD and DM (P=0.190). The trend toward to higher success rates for LDL-C and apo B goal attainments in men than in women were noteworthy across all categorizations although only in all patients and in DM alone patients were the statistically significant differences found (P<0.01).
  
  
  CONCLUSIONS
  The LDL-C lags behind the apo B in goal attainments in Chinese patients. Whether these discrepancies are associated with the occurrence differences for CAD and for stroke between the East Asia and the Western countries warrants further study.
authors.affiliation: Division of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: He
authors.affiliation: Division of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Xiang-Jun
authors.initials: XJ
authors.lastname: Yang
authors.affiliation: Division of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Division of Cardiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Xu
keywords: Apolipoprotein B (apo B); coronary artery disease (CAD); diabetes mellitus (DM); goal attainments; low density lipoprotein cholesterol (LDL-C)