title: Improvement in UV protection retention capability and reduction in skin penetration of benzophenone-3 with mesoporous silica as drug carrier by encapsulation.
abstract: In this study, various amounts of benzophenone-3 (BP-3), a solid-type of organic UV-filter, were encapsulated in mesoporous silica (MS) to form the BP-3 encapsulated by MS UV-filters (BESs), BES-1 and BES-2, via in-situ sol-gel process. The characterization of BESs was completed using Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results showed that of the BES filters, BES-2 containing emulsion (BES-2-E) exhibited about 2 times and 1.64 times higher SPF and erythemal UV-A PF values, respectively, and after 3 months about 7-8 times higher protection retention capability than the free BP-3 containing emulsion (BP-3-E). Moreover, the result of the in vitro skin penetration test using Franz glass diffusion cell indicated that the skin permeation of BP-3 from BESs was about 3 times lower than from BP-3-E. This property is particularly important for sunscreens because the amount of sunscreen penetration inside the stratum corneum directly correlates to its UV protection ability, and consequently its ability to reduce phototoxic and photo-allergic reactions that are damaging to the skin. The results of this study demonstrated the potential of as-prepared BES-2 as a UV-filter for cosmetic products.
authors.affiliation: Department of Chemistry, Center for Nanotechnology, Center for Biomedical Technology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung-Li 32023, Taiwan, ROC; Department of Cosmetic Science, Vanung University, 1 Van-Nung Road, Chung-Li, Taoyuan County 32061, Taiwan, ROC.
authors.forename: C C
authors.initials: CC
authors.lastname: Li
authors.affiliation: Master Program of Nanotechnology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung-Li 32023, Taiwan, ROC.
authors.forename: Y T
authors.initials: YT
authors.lastname: Lin
authors.affiliation: Department of Chemistry, Center for Nanotechnology, Center for Biomedical Technology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung-Li 32023, Taiwan, ROC.
authors.forename: Y T
authors.initials: YT
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Center for Nanotechnology, Center for Biomedical Technology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung-Li 32023, Taiwan, ROC.
authors.forename: S F
authors.initials: SF
authors.lastname: Sie
authors.affiliation: Department of Chemistry, Center for Nanotechnology, Center for Biomedical Technology, Chung Yuan Christian University, 200 Chung-Pei Road, Chung-Li 32023, Taiwan, ROC. Electronic address: yuiwhei@cycu.edu.tw.
authors.forename: Y W
authors.initials: YW
authors.lastname: Chen-Yang
mesh_terms: D001577:Benzophenones / Q000737:chemistry* / Q000378:metabolism; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D005782:Gels / Q000737:chemistry / Q000378:metabolism; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D059405:Sun Protection Factor; D013473:Sunscreening Agents / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D001577:Benzophenones; D004337:Drug Carriers; D004655:Emulsions; D005782:Gels; D013473:Sunscreening Agents; D012822:Silicon Dioxide; C005290:oxybenzone
keywords: Benzophenone-3; Drug carrier; In vitro release and skin penetration; Mesoporous silica; Organic UV-filter