title: Brain Abscesses Due to Aspergillus nidulans Infection During Induction Chemotherapy for Acute Lymphoblastic Leukemia.
abstract: We present the case of a 3-year-old boy who was diagnosed with cerebral abscesses due to Aspergillus nidulans infection on day 28 of induction chemotherapy for acute lymphoblastic leukemia. He responded well to treatment with voriconazole and caspofungin, making a full recovery. There are very few cases of invasive aspergillosis reported in children during induction chemotherapy for acute leukemia and A. nidulans is rare in the absence of chronic granulomatous disease.
authors.affiliation: *Department of Paediatrics, Division of Infectious Diseases ‡Department of Paediatrics, Division of Hematology and Oncology, University of British Columbia and BC Children's Hospital §Child and Family Research Institute, Vancouver, BC, Canada †Department of Paediatrics, University of Oxford, Oxford, UK.
authors.forename: Manish
authors.initials: M
authors.lastname: Sadarangani
authors.forename: Melissa
authors.initials: M
authors.lastname: Harvey
authors.forename: Allison
authors.initials: A
authors.lastname: McDonald
authors.forename: David P
authors.initials: DP
authors.lastname: Speert
authors.forename: David
authors.initials: D
authors.lastname: Dix
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology; D001233:Aspergillus nidulans / Q000472:pathogenicity; D001922:Brain Abscess / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology; D000077336:Caspofungin; D002675:Child, Preschool; D054714:Echinocandins / Q000627:therapeutic use*; D006801:Humans; D060828:Induction Chemotherapy / Q000009:adverse effects*; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000139:chemically induced / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D011379:Prognosis; D065819:Voriconazole / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin; D065819:Voriconazole