title: Effects of Material Properties on Bacterial Adhesion and Biofilm Formation.
abstract: Adhesion of microbes, such as bacteria and fungi, to surfaces and the subsequent formation of biofilms cause multidrug-tolerant infections in humans and fouling of medical devices. To address these challenges, it is important to understand how material properties affect microbe-surface interactions and engineer better nonfouling materials. Here we review the recent progresses in this field and discuss the main challenges and opportunities. In particular, we focus on bacterial biofilms and review the effects of surface energy, charge, topography, and stiffness of substratum material on bacterial adhesion. We summarize how these surface properties influence oral biofilm formation, and we discuss the important findings from nondental systems that have potential applications in dental medicine.
authors.affiliation: Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY, USA Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY, USA.
authors.forename: F
authors.initials: F
authors.lastname: Song
authors.affiliation: Department of Orthodontics and Divisions of Pediatric Dentistry & Community Oral Health, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: H
authors.initials: H
authors.lastname: Koo
authors.affiliation: Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY, USA Syracuse Biomaterials Institute, Syracuse University, Syracuse, NY, USA Department of Civil and Environmental Engineering, Syracuse University, Syracuse, NY, USA Department of Biology, Syracuse University, Syracuse, NY, USA dren@syr.edu.
authors.forename: D
authors.initials: D
authors.lastname: Ren
mesh_terms: D001422:Bacterial Adhesion / Q000502:physiology*; D001672:Biocompatible Materials / Q000737:chemistry*; D018441:Biofilms / Q000254:growth & development*; D002448:Cell Adhesion / Q000502:physiology; D003764:Dental Materials / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D003764:Dental Materials
keywords: bacteria; biofouling; biomaterials; dental implants; dentistry; infection control