title: Physical activity as a protective factor for development of non-alcoholic fatty liver in men.
abstract: OBJECTIVE
  To determine the impact of physical activity on the prevalence of fatty liver, metabolic and cardiovascular disease in adult men.
  
  
  METHODS
  This study evaluated 1,399 men (40.7±8.18 years) with body mass index of 26.7kg/m2 (±3.4) who participated in the Protocol of Preventive Health Check-up at Hospital Israelita Albert Einstein from January to October 2011. We conducted tests of serum blood glucose, total cholesterol, LDL, HDL, triglycerides, reactive c-protein, aspartate transaminase, alanine transaminase and gamma-glutamyl transpeptidase. The statistical analysis comprised in the comparison of mean and standard deviation. The analysis of variance was based in two paths of two way ANOVA, Student's t-test, Mann Whitney U test, Wald test and χ2. We considered a significance level at p<0.05 and correlation of univariate Poison with 95% confidence interval.
  
  
  RESULTS
  Fatty liver was diagnosed in 37.0% of the sample. Triglyceride levels of active men with fatty liver were 148.2±77.6mg/dL while inactive men with fatty liver had 173.4±15.6mg/dL. The remaining serum levels were normal. Inactive individuals showed higher values than active. In addition, inactive individuals have 10.68 times higher risk of developing fatty liver compared with active.
  
  
  CONCLUSIONS
  Physical activity improves metabolic parameters such as triglycerides, weight control, HDL, which interfere in the development of fatty liver. Physically active individuals had lower fatty liver prevalence regardless of values of body composition and lipid profile, leading the conclusion that physical activity has a protective role against development of fatty liver.
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Carla Giuliano de Sá
authors.initials: CG
authors.lastname: Pinto
authors.affiliation: Universidade São Judas Tadeu, São Paulo, SP, Brazil.
authors.forename: Marcio
authors.initials: M
authors.lastname: Marega
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: José Antonio Maluf de
authors.initials: JA
authors.lastname: Carvalho
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Felipe Gambetta
authors.initials: FG
authors.lastname: Carmona
authors.affiliation: Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
authors.forename: Carlos Eduardo Felix
authors.initials: CE
authors.lastname: Lopes
authors.affiliation: Universidade São Judas Tadeu, São Paulo, SP, Brazil.
authors.forename: Fabio Luis
authors.initials: FL
authors.lastname: Ceschini
authors.affiliation: Universidade São Judas Tadeu, São Paulo, SP, Brazil.
authors.forename: Danilo Sales
authors.initials: DS
authors.lastname: Bocalini
authors.affiliation: Universidade São Judas Tadeu, São Paulo, SP, Brazil.
authors.forename: Aylton José
authors.initials: AJ
authors.lastname: Figueira Junior
mesh_terms: D000328:Adult; D000367:Age Factors; D000410:Alanine Transaminase / Q000097:blood; D000886:Anthropometry; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D001938:Brazil / Q000453:epidemiology; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood; D004812:Epidemiologic Methods; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D009765:Obesity / Q000150:complications; D065840:Protective Factors; D014280:Triglycerides / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase