title: Type 1 diabetes is not associated with an increased prevalence of hepatic steatosis.
abstract: OBJECTIVE
  Non-alcoholic fatty liver disease (NAFLD) is commonly associated with Type 2 diabetes. Recently, it has been suggested that NAFLD is also frequently associated with Type 1 diabetes and diabetic complications. In this study, we set out to determine whether Type 1 diabetes was associated with liver fat content measured using magnetic resonance imaging.
  
  
  METHODS
  One hundred and twenty-eight patients with Type 1 diabetes, 264 patients with Type 2 diabetes and 67 participants without diabetes were included in this study. Hepatic steatosis was defined as a liver fat content > 5.5%.
  
  
  RESULTS
  People with Type 1 diabetes and controls were similar for age and BMI. Liver fat content was significantly higher in patients with Type 2 diabetes than in patients with Type 1 diabetes and controls. In the control group, nine people (13.4%) had steatosis compared with six (4.7%) patients with Type 1 diabetes (P = 0.04). Among patients with Type 2 diabetes group, 166 (62.8%) had steatosis. In multivariate analysis that included patients with Type 1 diabetes and participants without diabetes, steatosis was associated only with BMI, whereas age, sex, statin therapy and Type 1 diabetes were not. In patients with Type 1 diabetes, there was no correlation between liver fat content and estimated glomerular filtration rate or carotid intima media thickness.
  
  
  CONCLUSIONS
  Our data showed that Type 1 diabetes was not associated with an increased prevalence of steatosis. Moreover, our study provided no specific arguments concerning a link between liver fat content and diabetic complications in patients with Type 1 diabetes.
authors.affiliation: Centre de Recherche INSERM Unité 866.|Services de diabétologie et endocrinologie.
authors.forename: J-M
authors.initials: JM
authors.lastname: Petit
authors.affiliation: Services de diabétologie et endocrinologie.
authors.forename: L
authors.initials: L
authors.lastname: Pedro
authors.affiliation: Centre de Recherche INSERM Unité 866.|Services de radiologie, Université de Bourgogne, Dijon, France.
authors.forename: B
authors.initials: B
authors.lastname: Guiu
authors.affiliation: Centre de Recherche INSERM Unité 866.
authors.forename: L
authors.initials: L
authors.lastname: Duvillard
authors.affiliation: Centre de Recherche INSERM Unité 866.|Services de diabétologie et endocrinologie.
authors.forename: B
authors.initials: B
authors.lastname: Bouillet
authors.affiliation: Centre de Recherche INSERM Unité 866.
authors.forename: V
authors.initials: V
authors.lastname: Jooste
authors.affiliation: Services de diabétologie et endocrinologie.
authors.forename: M
authors.initials: M
authors.lastname: Habchi
authors.affiliation: Services de diabétologie et endocrinologie.
authors.forename: E
authors.initials: E
authors.lastname: Crevisy
authors.affiliation: Services de diabétologie et endocrinologie.
authors.forename: C
authors.initials: C
authors.lastname: Fourmont
authors.affiliation: Services de diabétologie et endocrinologie.
authors.forename: P
authors.initials: P
authors.lastname: Buffier
authors.affiliation: Centre de Recherche INSERM Unité 866.
authors.forename: P
authors.initials: P
authors.lastname: Hillon
authors.affiliation: Centre de Recherche INSERM Unité 866.|Services de radiologie, Université de Bourgogne, Dijon, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Cercueil
authors.affiliation: Centre de Recherche INSERM Unité 866.|Services de diabétologie et endocrinologie.
authors.forename: B
authors.initials: B
authors.lastname: Verges
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008099:Liver / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D009765:Obesity / Q000150:complications; D050177:Overweight / Q000150:complications; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors