title: Hematopoietic stem cell transplantation for primary cutaneous γδ T-cell lymphoma and refractory subcutaneous panniculitis-like T-cell lymphoma.
abstract: BACKGROUND
  The panniculitic T-cell lymphomas (TCLs) comprise 2 distinct entities, αβ subcutaneous panniculitis-like TCL (SPTCL) and the γδ cutaneous TCLs with pannicular involvement primary cutaneous γδ (PCGD)-TCL. Although outcomes for most patients with SPTCL are favorable, those with PCGD-TCLs generally have an inferior outcome, and treatment strategies have not been well defined. Allogeneic hematopoietic stem cell transplantation (HSCT) has been shown to be a potentially curative strategy in aggressive TCLs and in refractory and advanced-stage mycosis fungoides.
  
  
  OBJECTIVE
  We sought to analyze the outcomes of HSCT for panniculitic cutaneous TCL.
  
  
  RESULTS
  Fourteen patients (4 SPTCL, 10 PCGD-TCL) presented with primarily pannicular T-cell infiltrates. Seven patients underwent allogeneic HSCT from matched-related donors and matched-unrelated donors of which 4 (57%) are alive (1 SPTCL, 3 PCGD-TCL) at 7.8, 6.9, 6.2, and 0.25 years. Two patients underwent autologous HSCT (1 SPTCL, 1 PCGD-TCL) and both are alive at a median follow-up of 1.91 years.
  
  
  CONCLUSIONS
  This study is limited by its retrospective nature and small sample size because of the rarity of SPTCL and PCGD-TCL.
  
  
  CONCLUSIONS
  Aggressive therapy followed by allogeneic HSCT is a promising treatment modality for patients with PCGD-TCL.
authors.affiliation: Yale School of Medicine, New Haven, Connecticut. Electronic address: Juliet.gibson@yale.edu.
authors.forename: Juliet Fraser
authors.initials: JF
authors.lastname: Gibson
authors.affiliation: Department of Medical Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
authors.forename: Onder
authors.initials: O
authors.lastname: Alpdogan
authors.affiliation: Department of Dermatology and Pathology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Antonio
authors.initials: A
authors.lastname: Subtil
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Michael
authors.initials: M
authors.lastname: Girardi
authors.affiliation: Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Lynn D
authors.initials: LD
authors.lastname: Wilson
authors.affiliation: Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Roberts
authors.affiliation: Hematology and Bone Marrow Transplantation, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Francine
authors.initials: F
authors.lastname: Foss
mesh_terms: D000328:Adult; D000368:Aged; D064591:Allografts; D064592:Autografts; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016410:Lymphoma, T-Cell, Cutaneous / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015434:Panniculitis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D049268:Positron-Emission Tomography / Q000379:methods; D012189:Retrospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
keywords: T-cell lymphoma; hematopoietic stem cell transplantation; primary cutaneous γδ T-cell lymphoma; subcutaneous panniculitis-like T-cell lymphoma; γ-δ