title: Opioid regimens in patients with chronic pain with multiple cytochrome P450 defects.
abstract: There is a subgroup of patients with chronic pain who have multiple cytochrome P450 enzyme defects. These patients tend to use opioids that are not metabolized by the CYP450 system and most apparently require a higher than average dosage. A significant number require nonoral administration.
authors.affiliation: Veract Intractable Pain Clinic, West Covina, California.
authors.forename: Forest
authors.initials: F
authors.lastname: Tennant
mesh_terms: D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D001711:Biotransformation; D059350:Chronic Pain / Q000175:diagnosis / Q000188:drug therapy*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D004333:Drug Administration Routes; D054796:Drug Dosage Calculations; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D010641:Phenotype; D017211:Treatment Failure
chemical_list: D000701:Analgesics, Opioid; D003577:Cytochrome P-450 Enzyme System