title: Comparative studies of binding potential of Prunus armeniaca and Prunus domestica gums in tablets formulations.
abstract: The current study was undertaken to compare the binding potential of Prunus armeniaca L. and Prunus domestica L. gums in tablets' formulations. Tablet batches (F-1 to F-9) were prepared Diclofenac sodium as model drug using 5%, 7.5% and 10% of each Prunus armeniaca L., Prunus domestica L. gums as binder. PVP K30 was used as a standard binder. Magnesium stearate was used as lubricant. Flow properties of granules (like bulk density, tapped density, Carr's index, Hausner's ratio, angle of repose) as well as the physical parameters of compressed tablets including hardness, friability, thickness and disintegration time were determined. Flow parameters of granules of all the batches were found good. Physical parameters (drug content, weight variation, thickness, hardness, friability, disintegration time) of formulated tablets were found within limit when tested. The dissolution studies showed that tablets formulations containing each Prunus domestica showed better binding capacity compared to Prunus armeniaca gum. The binding potential increased as the concentration of gums increased. The FTIR spectroscopic investigation showed that the formulations containing plant gum are compatible with the drug and other excipients used.
authors.affiliation: Department of Pharmacy, Sarhad University of Science and Information Technology Peshawar, Khyber Pakhtunkhwa, Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Rahim
authors.affiliation: Department of Pharmacy, University of Malakand, Chakdara, Khyber Pakhtunkhwa, Pakistan.
authors.forename: Mir Azam
authors.initials: MA
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, University of Malakand, Chakdara, Khyber Pakhtunkhwa, Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Sadiq
authors.affiliation: Department of Pharmacy, University of Malakand, Chakdara, Khyber Pakhtunkhwa, Pakistan.
authors.forename: Shahzeb
authors.initials: S
authors.lastname: Khan
authors.affiliation: Department of Pharmacy, Sarhad University of Science and Information Technology Peshawar, Khyber Pakhtunkhwa, Pakistan.
authors.forename: Kamran Ahmad
authors.initials: KA
authors.lastname: Chishti
authors.affiliation: Department of Pharmacy, Gandhara University Peshawar, Khyber Pakhtunkhwa, Pakistan.
authors.forename: Inayat U
authors.initials: IU
authors.lastname: Rahman
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D006244:Hardness; D053149:Plant Gums / Q000737:chemistry*; D027861:Prunus; D012995:Solubility; D013607:Tablets / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D053149:Plant Gums; D013607:Tablets; D004008:Diclofenac