title: Recurrent respiratory papillomatosis in northern Sweden: clinical characteristics and practical guidance.
abstract: CONCLUSIONS
  Recurrent respiratory papillomatosis (RRP) patients with high surgical treatment frequency (≥ 1/year, HF) were significantly younger and had a more widespread laryngeal disease compared to a low frequency treated group (< 1 treatment/year, LF). This study confirms the existence of a clinical RRP group, not primarily related to HPV sub-type, but more care-intensive and in need of more vigilant follow-up.
  
  
  OBJECTIVE
  RRP is associated with high morbidity due to its influence on breathing and voice. The purpose of this study was to characterize RRP patients in northern Sweden and investigate possible predictor factors affecting therapeutic needs.
  
  
  METHODS
  Patients from the regional referral area (northern Sweden) were categorized for age, disease duration, juvenile or adult onset, profile of disease development, number of surgical sessions in relation to disease duration, laryngeal deposition of papilloma, gender, and HPV sub-types, in order to identify patients with increased need for frequent surgical treatment.
  
  
  RESULTS
  The median age of the RRP patients (n = 48) was 44.5 years; 34 (71%) were males and 14 (29%) females, most were infected with HPV 6. Patients with high surgical treatment frequency/year were significantly younger and showed more widespread papillomatous vegetation in the larynx, compared to the low frequency treated group.
authors.affiliation: Department of Clinical Sciences, Division of Otorhinolaryngology; Umeå University , Umeå , Sweden.
authors.forename: Christos
authors.initials: C
authors.lastname: Loizou
authors.forename: Göran
authors.initials: G
authors.lastname: Laurell
authors.forename: Andreas
authors.initials: A
authors.lastname: Arvidsson
authors.forename: David
authors.initials: D
authors.lastname: Lindquist
authors.forename: Karin
authors.initials: K
authors.lastname: Nylander
authors.forename: Katarina
authors.initials: K
authors.lastname: Olofsson
mesh_terms: D000328:Adult; D001706:Biopsy; D004724:Endoscopy; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D012720:Severity of Illness Index; D013548:Sweden / Q000453:epidemiology
keywords: HPV vaccine; Human papilloma virus; airway surgery; data analysis; gender; recurrent respiratory papillomatosis; tonsillar cancer