title: BIRC6-ALK, a Novel Fusion Gene in ALK Break-Apart FISH-Negative Lung Adenocarcinoma, Responds to Crizotinib.
authors.affiliation: Departments of *Pathology, †Medical Oncology, ‡Diagnostic Imaging, §Laboratory of Cell and Molecular Biology and State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; ‖MyGenostics Inc., Baltimore, MD, USA; ¶Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; #Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, China; and **State Key Laboratory of Oncology in Southern China, Guangzhou, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Shan
authors.forename: Peidi
authors.initials: P
authors.lastname: Jiang
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Weilong
authors.initials: W
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Yixin
authors.initials: Y
authors.lastname: Zeng
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Jiao
authors.forename: Jianming
authors.initials: J
authors.lastname: Ying
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D000077192:Adenocarcinoma of Lung; D000077548:Anaplastic Lymphoma Kinase; D000077547:Crizotinib; D005260:Female; D050939:Gene Fusion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011720:Pyrazoles / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: C401541:BIRC6 protein, human; D051034:Inhibitor of Apoptosis Proteins; D047428:Protein Kinase Inhibitors; D011720:Pyrazoles; D011725:Pyridines; D000077547:Crizotinib; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases