title: Emerging Treatment Paradigms in Radiation Oncology.
abstract: Rapid advancements in radiotherapy and molecularly targeted therapies have resulted in the development of potential paradigm-shifting use of radiotherapy in the treatment of cancer. In this review, we discuss some of the most promising therapeutic approaches in the field of radiation oncology. These strategies include the use of highly targeted stereotactic radiotherapy and particle therapy as well as combining radiotherapy with agents that modulate the DNA damage response, augment the immune response, or protect normal tissues.
authors.affiliation: Department of Radiation Oncology, Stanford University, Stanford, California. qle@stanford.edu.
authors.forename: Quynh-Thu
authors.initials: QT
authors.lastname: Le
authors.affiliation: Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shirato
authors.affiliation: Department of Radiation Oncology, Stanford University, Stanford, California.
authors.forename: Amato J
authors.initials: AJ
authors.lastname: Giaccia
authors.affiliation: Department of Radiation Oncology, Stanford University, Stanford, California.
authors.forename: Albert C
authors.initials: AC
authors.lastname: Koong
mesh_terms: D004249:DNA Damage / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy*; D018787:Radiation Oncology / Q000379:methods; D016634:Radiosurgery