title: Extract of fetal membrane would inhibit thrombosis and hemolysis.
abstract: The innermost layer of fetal membranes is amnion which has anti-adhesive, anti-inflammation and viscoelastic properties, as well as low immunogenicity. Amniotic membrane has been employed in variety of clinical fields as a natural biomaterial. Amniotic epithelial cells possess stem cell characteristics and capability to differentiate into endothelial cells. The basement membrane of amnion is an extracellular matrix enriched scaffold to support adhesion of endothelial cells. The matrix of amniotic membrane contains two kinds of glycosaminoglycans including perlecan (a heparan sulfate proteoglycan) and hyaluronic acid which both inhibit blood coagulation. Moreover, the other ingredients of amniotic membrane such as pigment-epithelium derived factor (PEDF), IL-10, MMP-9 inhibit platelet aggregation. Based on some biochemical and biomechanical evidences, we hypothesized in this paper that amniotic membrane could prevent thrombosis and hemolysis; therefore, has the capability to be applied in blood contacting devices and implants.
authors.affiliation: Department of Tissue Engineering, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: niknejad@sbmu.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Niknejad
authors.affiliation: Department of Tissue Engineering, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Yazdanpanah
authors.affiliation: Department of Tissue Engineering, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mona
authors.initials: M
authors.lastname: Kakavand
mesh_terms: D020099:Coated Materials, Biocompatible / Q000008:administration & dosage* / Q000737:chemistry; D005321:Extraembryonic Membranes / Q000737:chemistry*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D013927:Thrombosis / Q000517:prevention & control*; D014020:Tissue Extracts / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D014020:Tissue Extracts