title: Hyperglycemia associated with seizure control in status epilepticus.
abstract: BACKGROUND
  Status epilepticus (SE) is a serious neurological condition and has a high mortality rate. Factors associated with seizure control measures in nonneurointensive care units (non-NICU) are limited.
  
  
  METHODS
  Adult patients diagnosed with SE at Khon Kaen hospital, Thailand from October 1st, 2010 to September 30th, 2012 were enrolled. Patients were categorized as having controlled seizures and having uncontrolled seizures. Controlled seizures were defined as seizures that were aborted without any recurrence, while uncontrolled seizures were defined as unstoppable or recurrent seizures. Clinical factors were analyzed to find factors associated with uncontrolled SE.
  
  
  RESULTS
  During the study period, there were 211 patients diagnosed with SE. Of those, 57 patients (27.01%) were in the group with controlled SE. Plasma glucose and serum albumin were two significant factors with adjusted ORs (95% CI) of 1.008 (1.001, 1.027) and 0.166 (0.059, 0.466) that differentiated patients with controlled seizures from patients with uncontrolled seizures. Central nervous system infections and cardiac arrests were also completely associated with the uncontrolled SE in the multivariate logistic analysis.
  
  
  CONCLUSIONS
  In the etiology of SE, high plasma glucose and low serum albumin levels were associated with uncontrolled seizures in patients with SE in the non-NICU setting. This article is part of a Special Issue entitled "Status Epilepticus".
authors.affiliation: Department of Medicine, Khon Kaen Hospital, Khon Kaen, Thailand.
authors.forename: Piyawan
authors.initials: P
authors.lastname: Chiewthanakul
authors.affiliation: Department of Medicine, Khon Kaen Hospital, Khon Kaen, Thailand; Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Parinya
authors.initials: P
authors.lastname: Noppaklao
authors.affiliation: Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Research Center in Back, Neck, Other Joint Pain and Human Performance (BNOJPH), Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Kittisak
authors.initials: K
authors.lastname: Sawanyawisuth
authors.affiliation: Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Integrated Epilepsy Research Group, Khon Kaen University, Khon Kaen, Thailand. Electronic address: somtia@kku.ac.th.
authors.forename: Somsak
authors.initials: S
authors.lastname: Tiamkao
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012640:Seizures / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D013226:Status Epilepticus / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D013785:Thailand / Q000453:epidemiology
chemical_list: D001786:Blood Glucose
keywords: Hyperglycemia; Outcomes; Prognosis; Risk factors; Status epilepticus