title: Hepcidin and iron disorders: new biology and clinical approaches.
abstract: Hepatic hormone hepcidin is a principal regulator of iron homeostasis and a pathogenic factor in common iron disorders. Hepcidin deficiency causes iron overload in hereditary hemochromatosis and iron-loading anemias, whereas hepcidin excess causes or contributes to the development of iron-restricted anemia in inflammatory diseases, infections, some cancers, and chronic kidney disease. Because of this, hepcidin may become a useful tool for diagnosis and management of iron disorders. Furthermore, a number of strategies that target hepcidin, its receptor, and its regulators are under development as novel therapeutic approaches for diseases associated with iron dysregulation.
authors.affiliation: Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.
authors.forename: J
authors.initials: J
authors.lastname: Arezes
authors.affiliation: David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA, USA.
authors.forename: E
authors.initials: E
authors.lastname: Nemeth
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D000818:Animals; D064451:Hepcidins / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019189:Iron Metabolism Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D058990:Molecular Targeted Therapy / Q000379:methods; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D064451:Hepcidins; D007501:Iron
keywords: Hepcidin; anemia; ferroportin; iron; iron overload