title: Synthesis, spectral characterization and DNA bindings of tridentate N2O donor Schiff base metal(II) complexes.
abstract: To evaluate the biological preference of synthetic small drugs towards DNA target, new metal based chemotherapeutic agents of Cu(II), Co(II), Ni(II) and Zn(II), 2,4-diiodo-6-((pyridin-2-ylmethylimino)methyl)phenol (L) Schiff base complexes (1, 2, 3 &4) having N,N,O donor system respectively were synthesized and thoroughly characterized. The IR results confirmed the tridentate binding of the ligand with metal centre during complexation and reflects the proposed structure. The density function theory calculations were also used to further investigate the electronic structure and properties of ligand and complexes. The preliminary investigation of herring Sperm (HS-DNA) interaction propensity of complexes 1-4 were carried out in Tris-HCl buffer at pH 7.1 to demonstrate their mode of interactions. The obtained results reveal that these complexes significantly interact with DNA on the grooves, further, this observed mode of interactions was also confirmed by molecular docking evaluations. The complexes 1-4 were also screened for antimicrobial evaluations which demonstrated that their significant activity against various human pathogens. The cleavage studies with pBR322 plasmid DNA revealed higher nuclease activity of 1 as compared to other complexes.
authors.affiliation: Department of Materials Science, School of Chemistry, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India.
authors.forename: Sellamuthu
authors.initials: S
authors.lastname: Kathiresan
authors.affiliation: Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India.
authors.forename: Thangavel
authors.initials: T
authors.lastname: Anand
authors.affiliation: Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Mugesh
authors.affiliation: Department of Materials Science, School of Chemistry, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India. Electronic address: annaraj.chem@mkuniversity.org.
authors.forename: Jamespandi
authors.initials: J
authors.lastname: Annaraj
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D005399:Fishes; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D008024:Ligands; D008297:Male; D008670:Metals / Q000737:chemistry; D018625:Microscopy, Atomic Force; D062105:Molecular Docking Simulation; D020030:Nitric Oxide Donors / Q000737:chemistry* / Q000378:metabolism; D009690:Nucleic Acid Conformation; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D011789:Quantum Theory; D012545:Schiff Bases / Q000737:chemistry*; D013094:Spermatozoa / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D008024:Ligands; D008670:Metals; D020030:Nitric Oxide Donors; D012545:Schiff Bases; D004247:DNA