title: A dose response randomised controlled trial of docosahexaenoic acid (DHA) in preterm infants.
abstract: Thirty one infants born less than 30 weeks׳ gestational age were randomised to receive either 40 (n=11), 80 (n=9) or 120 (n=11) mg/kg/day of docosahexaenoic acid (DHA) respectively as an emulsion, via the feeding tube, commenced within 4 days of the first enteral feed. Twenty three infants were enroled in non-randomised reference groups; n=11 who had no supplementary DHA and n=12 who had maternal DHA supplementation. All levels of DHA in the emulsion were well tolerated with no effect on number of days of interrupted feeds or days to full enteral feeds. DHA levels in diets were directly related to blood DHA levels but were unrelated to arachidonic acid (AA) levels. All randomised groups and the maternal supplementation reference group prevented the drop in DHA levels at study end that was evident in infants not receiving supplementation. Australian New Zealand Clinical Trials Registry: ACTRN12610000382077.
authors.affiliation: Child Nutrition and FOODplus Research Centres, Women׳s and Children׳s Health Research Institute, Flinders Medical Centre, Women׳s and Children׳s Hospital and The University of Adelaide, South Australia, Australia; Healthy Mothers, Babies and Children, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; School of Paediatrics and Reproductive Health, The University of Adelaide, South Australia.
authors.forename: C T
authors.initials: CT
authors.lastname: Collins
authors.affiliation: School of Population Health, The University of Adelaide, Adelaide, South Australia, Australia.
authors.forename: T R
authors.initials: TR
authors.lastname: Sullivan
authors.affiliation: Healthy Mothers, Babies and Children, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; Neonatal Medicine, Women׳s and Children׳s Hospital, Adelaide, South Australia, Australia; The Robinson Research Institute, The University of Adelaide, South Australia, Australia.
authors.forename: A J
authors.initials: AJ
authors.lastname: McPhee
authors.affiliation: Neonatal Medicine, Women׳s and Children׳s Hospital, Adelaide, South Australia, Australia; The Robinson Research Institute, The University of Adelaide, South Australia, Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Stark
authors.affiliation: Child Nutrition and FOODplus Research Centres, Women׳s and Children׳s Health Research Institute, Flinders Medical Centre, Women׳s and Children׳s Hospital and The University of Adelaide, South Australia, Australia; Healthy Mothers, Babies and Children, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; School of Paediatrics and Reproductive Health, The University of Adelaide, South Australia.
authors.forename: M
authors.initials: M
authors.lastname: Makrides
authors.affiliation: Child Nutrition and FOODplus Research Centres, Women׳s and Children׳s Health Research Institute, Flinders Medical Centre, Women׳s and Children׳s Hospital and The University of Adelaide, South Australia, Australia; Healthy Mothers, Babies and Children, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; School of Agriculture, Food and Wine, The University of Adelaide, South Australia, Australia. Electronic address: robert.gibson@adelaide.edu.au.
authors.forename: R A
authors.initials: RA
authors.lastname: Gibson
mesh_terms: D016718:Arachidonic Acid / Q000097:blood; D001315:Australia; D002462:Cell Membrane / Q000737:chemistry; D002658:Developmental Disabilities / Q000517:prevention & control; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000008:administration & dosage* / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000737:chemistry / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism
chemical_list: D010743:Phospholipids; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid
keywords: Docosahexaenoic acid; Dose response; Infant; Long chain polyunsaturated fatty acid; Premature