title: Expression of metastasis-associated gene-1 is associated with bone invasion and tumor stage in human pituitary adenomas.
abstract: BACKGROUND
  Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells.
  
  
  METHODS
  In the present study, we evaluated the expression levels of MTA1 in a cohort of human pituitary tumors (n=95) and examined the relationship between MTA1 expression and the pathological, clinical and aggressiveness of these tumors.
  
  
  RESULTS
  MTA1 was expressed at significantly higher levels in large tumors and in those with higher tumor grade. It was also observed that tumors that had invaded the suprasellar bones and tumors that destructed the sella had significantly higher levels than those without bone involvement (p<005). Although there did not appear to exist any relationship between MTA1 and cystic lesions in the tumors, endocrine-active tumors, namely those secreting prolactin, growth hormone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) had significantly lower MTA1 transcript levels than inactive tumors.
  
  
  CONCLUSIONS
  MTA1 is associated with the aggressive nature of pituitary tumors and may be a potential therapeutic target in this tumor type.
authors.affiliation: Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. China Institute of Cancer, Capital Medical University, FengTai, Beijing, P.R. China Brain Institute, Capital Medical University, FengTai, Beijing, P.R. China Cardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. China.
authors.forename: Wang
authors.initials: W
authors.lastname: Jia
authors.affiliation: Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. China Department of Neurosurgery, ZhaoYuan RenMin Hospital, YanTai, Shandong, P.R. China.
authors.forename: Jinkui
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Institute of Cancer, Capital Medical University, FengTai, Beijing, P.R. China Brain Institute, Capital Medical University, FengTai, Beijing, P.R. China Cardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. China China-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. China Cardiff University School of Medicine, Cardiff, U.K.
authors.forename: Tracey A
authors.initials: TA
authors.lastname: Martin
authors.affiliation: Institute of Cancer, Capital Medical University, FengTai, Beijing, P.R. China Brain Institute, Capital Medical University, FengTai, Beijing, P.R. China Cardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. China China-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. China Cardiff University School of Medicine, Cardiff, U.K.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Sanders
authors.affiliation: Institute of Cancer, Capital Medical University, FengTai, Beijing, P.R. China Cardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. China China-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Yang
authors.affiliation: Institute of Cancer, Capital Medical University, FengTai, Beijing, P.R. China Cardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. China China-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. China.
authors.forename: Shan
authors.initials: S
authors.lastname: Cheng
authors.affiliation: Institute of Cancer, Capital Medical University, FengTai, Beijing, P.R. China Cardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. China China-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. China.
authors.forename: Hefen
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. China.
authors.forename: Guijun
authors.initials: G
authors.lastname: Jia
authors.affiliation: Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. China.
authors.forename: Runchun
authors.initials: R
authors.lastname: Lu
authors.affiliation: Institute of Cancer, Capital Medical University, FengTai, Beijing, P.R. China Brain Institute, Capital Medical University, FengTai, Beijing, P.R. China Cardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. China China-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. China Cardiff University School of Medicine, Cardiff, U.K.
authors.forename: Wen G
authors.initials: WG
authors.lastname: Jiang
mesh_terms: D000236:Adenoma / Q000235:genetics* / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006655:Histone Deacetylases / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D012097:Repressor Proteins / Q000235:genetics*; D015534:Trans-Activators; D047368:Tumor Burden
chemical_list: C089320:MTA1 protein, human; D012097:Repressor Proteins; D015534:Trans-Activators; D006655:Histone Deacetylases
keywords: MTA1; bone invasion; pituitary adenoma; sella destruction; staging