title: Biological and pharmacological activities of 1,3,4-thiadiazole based compounds.
abstract: The chemistry of 1,3,4-thiadiazoles is very well known. A universal and commonly used method of the synthesis of different 2,5-disubstituted 1,3,4-thiadiazoles includes the cyclization of appropriate linear organic derivatives. They are widely known as compounds with various kinds of biological activities showing anticancer properties against human cancers and acting as diuretic, antibacterial, antifungal, antitubercular and leishmanicidal agents. Many of them influence on OUN exhibiting anticonvulsant, anti-inflammatory, antidepressant, analgesic and anxiolytic effects. The molecular target of 1,3,4-thiadiazoles includes the following enzymes: carbonic anhydrase (CA), cyclooxygenase (CO), neutral endopeptidase (NEP), aminopeptidase N (APN), matrix metalloproteinases (MMPs), phosphodiesterases (PDEs) and c-Src/Abl tyrosine kinase. In this presentation, recent achievements in the medicinal chemistry of 1,3,4-thiadiazole based compounds are reviewed.
authors.affiliation: Department of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland. joanna.matysiak@up.lublin.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Matysiak
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D011485:Protein Binding; D021281:Quantitative Structure-Activity Relationship; D013830:Thiadiazoles / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D002257:Carbonic Anhydrase Inhibitors; D016861:Cyclooxygenase Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D010726:Phosphodiesterase Inhibitors; D013830:Thiadiazoles; C058949:1,3,4-thiadiazole