title: Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi.
abstract: Cyathane diterpenoids, occurring exclusively in higher basidiomycete (mushrooms), represent a structurally diverse class of natural products based on a characteristic 5-6-7 tricyclic carbon scaffold, including 105 members reported to date. These compounds show a diverse range of biological activities, such as antimicrobial, anti-MRSA, agonistic toward the kappa-opioid receptor, antiinflammatory, anti-proliferative and nerve growth factor (NGF)-like properties. The present review focuses on the structure diversity, structure elucidation and biological studies of these compounds, including mechanisms of actions and structure-activity relationships (SARs). In addition, new progress in chemical synthesis of cyathane diterpenoids is discussed.
authors.forename: Hao-Yu
authors.initials: HY
authors.lastname: Tang
authors.forename: Xia
authors.initials: X
authors.lastname: Yin
authors.forename: Cheng-Chen
authors.initials: CC
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Jia
authors.affiliation: Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, P.R. China. jinminggao@nwsuaf.edu.cn.
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Gao
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D004224:Diterpenes; C497675:cyathane; D020932:Nerve Growth Factor