title: Cancer antigen-125 levels predict long-term mortality in chronic obstructive pulmonary disease.
abstract: BACKGROUND
  Cancer antigen-125 (CA-125) might be a useful biomarker to predict long-term mortality in patients with recent exacerbation of chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  A total of 87 consecutive patients with COPD were evaluated prospectively. Mean age of patients was 68 ± 10 years (55% males, 45% females) with a median follow-up period of 49 months. Optimal cut-off value of CA-125 to predict mortality was found as >93.34 U/ml, with 91% specificity and 40% sensitivity.
  
  
  RESULTS
  After follow-up, 20 out of 87 (23%) experienced cardiovascular death. CA-125 levels were higher among those who died compared to those who survived [55 (12-264) versus 28 (5-245) U/ml, p = 0.013]. In multivariate Cox proportional-hazards model with forward stepwise method, only CA-125 > 93.34 U/ml on admission (HR = 3.713, 95% CI: 1.035-13.323, p = 0.044) remained associated with an increased risk of death.
  
  
  CONCLUSIONS
  For the first time, we demonstrated that CA-125 helps the risk stratification of patients with COPD.
authors.affiliation: Department of Cardiology and.
authors.forename: Hakki
authors.initials: H
authors.lastname: Kaya
authors.forename: Ali
authors.initials: A
authors.lastname: Zorlu
authors.forename: Hasan
authors.initials: H
authors.lastname: Yucel
authors.forename: Omer Tamer
authors.initials: OT
authors.lastname: Dogan
authors.forename: Savas
authors.initials: S
authors.lastname: Sarikaya
authors.forename: Gulay
authors.initials: G
authors.lastname: Aydin
authors.forename: Tarik
authors.initials: T
authors.lastname: Kivrak
authors.forename: Mehmet Birhan
authors.initials: MB
authors.lastname: Yilmaz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods; D053208:Kaplan-Meier Estimate; D008168:Lung / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D012129:Respiratory Function Tests; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen
keywords: CA-125; cancer antigen-125; chronic obstructive pulmonary disease; long-term mortality; risk stratification