title: Current use of silkworm larvae (Bombyx mori) as an animal model in pharmaco-medical research.
abstract: We advocate the use of silkworm larvae, Bombyx mori, as an animal model for discovery of drug candidates. We have established several disease models using silkworms, which offer technical advantages in drug development and the study of host-pathogen interaction. This mini review briefly describes recent trends in the use of silkworm larvae as a non-mammalian model for drug discovery and it offers suggestions regarding the potential for silkworm use in pharmaceutical-biomedical research.
authors.affiliation: Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo.
authors.forename: Don Daniel
authors.initials: DD
authors.lastname: Nwibo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hamamoto
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Chikara
authors.initials: C
authors.lastname: Kaito
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sekimizu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D035843:Biomedical Research; D012831:Bombyx; D055808:Drug Discovery; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007814:Larva; D023421:Models, Animal
chemical_list: D000900:Anti-Bacterial Agents; D007004:Hypoglycemic Agents