title: Synthesis of daumone derivatives and their antiangiogenic activities on chorioallantoic membrane.
abstract: Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Ricci
authors.forename: Dongguk
authors.initials: D
authors.lastname: Min
authors.forename: Miyeon
authors.initials: M
authors.lastname: Oh
authors.forename: Hyenchong
authors.initials: H
authors.lastname: Lim
authors.forename: Won-Yoon
authors.initials: WY
authors.lastname: Chung
authors.forename: Kwang-Kyun
authors.initials: KK
authors.lastname: Park
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, Korea. mjung@yonsei.ac.kr.
authors.forename: Mankil
authors.initials: M
authors.lastname: Jung
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D049033:Chorioallantoic Membrane / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010675:Pheromones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D020533:Angiogenesis Inhibitors; D005227:Fatty Acids; D010675:Pheromones; C496586:daumone, C elegans