title: Isolation, semi-synthesis and bio-evaluation of spatane derivatives from the brown algae Stoechospermum marginatum.
abstract: A comprehensive investigation of chemical constituents from brown algae Stoechospermum marginatum yielded ten known spatane compounds (1-10). To develop the compound libraries on these scaffolds, a series of semi synthetic derivatives was prepared (1a-1d, 2a, 4a, 11 and 12) and investigated for their anti-microbial and anticancer activities. The results indicated that compounds 2a, 4, 1b and 4a exhibited potent cytotoxic activities against B16F10 cancer cell line with IC50 values of 3.28, 3.45, 3.62 and 4.11 μg/ml respectively, which are comparable to the standard drug (etoposide IC50=4.12 μg/ml). In addition, 4 and 1b were also manifested potent antimicrobial activities against tested bacterial and fungal strains. This is the first Letter on the synthesis and biological activities of these novel derivatives.
authors.affiliation: Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
authors.forename: B
authors.initials: B
authors.lastname: Chinnababu
authors.affiliation: Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
authors.forename: S
authors.initials: S
authors.lastname: Purushotham Reddy
authors.affiliation: Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
authors.forename: P
authors.initials: P
authors.lastname: Sankara Rao
authors.affiliation: Biology and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
authors.forename: V
authors.initials: V
authors.lastname: Loka Reddy
authors.affiliation: BEEC Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
authors.forename: B
authors.initials: B
authors.lastname: Sudheer Kumar
authors.affiliation: Biology and Biotechnology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
authors.forename: J Venkateswara
authors.initials: JV
authors.lastname: Rao
authors.affiliation: BEEC Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
authors.forename: R S
authors.initials: RS
authors.lastname: Prakasham
authors.affiliation: Division of Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India. Electronic address: suresh@iict.res.in.
authors.forename: K
authors.initials: K
authors.lastname: Suresh Babu
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D000459:Phaeophyceae / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents
keywords: Anti-cancer activity; Anti-microbial activity; Brownseaweed; Dictyotaceae; Semi-synthesis; Spatane diterpenoids; Stochospermum marginatum