title: Lipid subclasses profiles and oxidative stress in aggressive periodontitis before and after treatment.
abstract: OBJECTIVE
  Associations between dyslipidaemia, oxidative stress and periodontitis have emerged in recent years. However, there is a lack of studies investigating these associations in aggressive periodontitis (AgP) cases. The aim of this study was to investigate the lipid and oxidative stress profiles in patients with AgP, and to relate them to clinical variables and interleukin (IL)-6 genetic variants.
  
  
  METHODS
  Twelve non-smoking Caucasian patients with AgP selected based on their IL6 haplotypes underwent periodontal non-surgical and surgical treatment. Peripheral blood samples taken at baseline and at six different time-points after treatment were processed to determine IL-6 circulating levels, lipid profiles (cholesterol, triglycerides, high-density lipoprotein [HDL] and low-density lipoprotein [LDL] subclasses) and oxidative stress markers (glutathione and total lipid hydroperoxide levels).
  
  
  RESULTS
  HDLs were the most prevalent lipoproteins, followed by intermediate-density lipoprotein, very-low-density lipoprotein and LDL. The LDL subclasses consisted mainly of the less atherogenic large LDL. The lipid profile did not consistently change after treatment up to 3 mo after surgery. Periodontal disease severity was associated with LDL levels and size. The IL6 haplotypes were associated with total cholesterol, triglycerides, HDL and LDL subclasses after adjusting for confounders. IL-6 circulating levels were associated with both very-low-density lipoprotein and lipid hydroperoxide levels.
  
  
  CONCLUSIONS
  Based on these data, we conclude that both periodontal disease severity and IL6 haplotypes may influence lipid profiles in AgP.
authors.affiliation: Periodontology Unit and Department of Clinical Research, UCL Eastman Dental Institute, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Nibali
authors.affiliation: Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.|Euro-Mediterranean Institute of Science and Technology, Palermo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rizzo
authors.affiliation: Euro-Mediterranean Institute of Science and Technology, Palermo, Italy.|Department of Biomedicine and Biotechnologies, University of Catania, Catania, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Li Volti
authors.affiliation: Periodontology Unit and Department of Clinical Research, UCL Eastman Dental Institute, London, UK.
authors.forename: F
authors.identifier: http://orcid.org/0000-0001-8654-935X
authors.initials: F
authors.lastname: D'Aiuto
authors.affiliation: Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
authors.forename: R V
authors.initials: RV
authors.lastname: Giglio
authors.affiliation: Euro-Mediterranean Institute of Science and Technology, Palermo, Italy.|Department of Drug Sciences, University of Catania, Catania, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Barbagallo
authors.affiliation: Periodontology Unit and Department of Clinical Research, UCL Eastman Dental Institute, London, UK.
authors.forename: G
authors.initials: G
authors.lastname: Pelekos
authors.affiliation: Periodontology Unit and Department of Clinical Research, UCL Eastman Dental Institute, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Donos
mesh_terms: D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D006239:Haplotypes; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000235:genetics*; D008055:Lipids / Q000097:blood* / Q000145:classification*; D008137:Longitudinal Studies; D008297:Male; D018384:Oxidative Stress; D016896:Treatment Outcome; D044465:White People; D055815:Young Adult
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D008055:Lipids
keywords: genetic; lipid; oxidative stress; periodontitis